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Sample records for survivability design guide

  1. Publications desktop survival guide

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    Purpose of this guide is to document and simplify the writing, reviewing, and production process for the Uranium Mill Tailings Remedial Action (UMTRA) Project Technical Assistance Contractor (TAC) staff and to provide specific answers concerning the content, style, and format of UMTRA Project documents. Goal of the UMTRA Project document preparation process is to deliver to the US DOE high-quality documents that meet requirements (meets expressed client needs; accurate and consistent technical content; clear writing; well organized document; consistent style). A document review process has been established to ensure that TAC documents are accurate, consistent, and well organized. The editing process applies standard rules for style and format, spelling, grammar, punctuation, and sentence structure to make the document consistent and easier to read. This guide sets forth the rules to be applied to UMTRA Project documents.

  2. Maintainability design guide

    International Nuclear Information System (INIS)

    Pack, R.W.

    1985-01-01

    The Human Factors Design Guide for Maintainability provides guidance for systematically incorporating good human factors techniques into the design of power plants. The guide describes a means of developing a comprehensive program plan to ensure compliance with the human factors approaches specified by the utility. The guide also provides specific recommendations for design practices, with examples, bases, and references. The recommendations are formatted for easy use by nuclear power plant design teams and by utility personnel involved in specification and design review. The guide was developed under EPRI research project RP2166-4 and is currently being published

  3. Control system design guide

    Energy Technology Data Exchange (ETDEWEB)

    Sellers, David; Friedman, Hannah; Haasl, Tudi; Bourassa, Norman; Piette, Mary Ann

    2003-05-01

    The ''Control System Design Guide'' (Design Guide) provides methods and recommendations for the control system design process and control point selection and installation. Control systems are often the most problematic system in a building. A good design process that takes into account maintenance, operation, and commissioning can lead to a smoothly operating and efficient building. To this end, the Design Guide provides a toolbox of templates for improving control system design and specification. HVAC designers are the primary audience for the Design Guide. The control design process it presents will help produce well-designed control systems that achieve efficient and robust operation. The spreadsheet examples for control valve schedules, damper schedules, and points lists can streamline the use of the control system design concepts set forth in the Design Guide by providing convenient starting points from which designers can build. Although each reader brings their own unique questions to the text, the Design Guide contains information that designers, commissioning providers, operators, and owners will find useful.

  4. Radiological design guide

    International Nuclear Information System (INIS)

    Evans, R.A.

    1994-01-01

    The purpose of this design guide is to provide radiological safety requirements, standards, and information necessary for designing facilities that will operate without unacceptable risk to personnel, the public, or the environment as required by the US Department of Energy (DOE). This design guide, together with WHC-CM-4-29, Nuclear Criticality Safety, WHC-CM-4-46, Nonreactor Facility Safety Analysis, and WHC-CM-7-5, Environmental Compliance, covers the radiation safety design requirements at Westinghouse Hanford Company (WHC). This design guide applies to the design of all new facilities. The WHC organization with line responsibility for design shall determine to what extent this design guide shall apply to the modifications to existing facilities. In making this determination, consideration shall include a cost versus benefit study. Specifically, facilities that store, handle, or process radioactive materials will be covered. This design guide replaces WHC-CM-4-9 and is designated a living document. This design guide is intended for design purposes only. Design criteria are different from operational criteria and often more stringent. Criteria that might be acceptable for operations might not be adequate for design

  5. The Classroom Teacher's Technology Survival Guide

    Science.gov (United States)

    Johnson, Doug

    2012-01-01

    This is a must-have resource for all K-12 teachers and administrators who want to really make the best use of available technologies. Written by Doug Johnson, an expert in educational technology, "The Classroom Teacher's Technology Survival Guide" is replete with practical tips teachers can easily use to engage their students and make their…

  6. Pneumatic conveying design guide

    CERN Document Server

    Mills, David

    1990-01-01

    Pneumatic Conveying Design Guide is a guide for the design of pneumatic conveying systems and includes detailed data and information on the conveying characteristics of a number of materials with a wide range of properties. This book includes logic diagrams for design procedures and scaling parameters for the conveying line configuration. It also explains how to improve the performance of pneumatic conveyors by optimizing, uprating, and extending the system or adapting it for a change of material. This book consists of 15 chapters divided into three sections and opens with an overview of the s

  7. REPOSITORY RADIATION SHIELDING DESIGN GUIDE

    International Nuclear Information System (INIS)

    M. Haas; E.M. Fortsch

    1997-01-01

    The scope of this document includes radiation safety considerations used in the design of facilities for the Yucca Mountain Site Characterization Project (YMP). The purpose of the Repository Radiation Shielding Design Guide is to document the approach used in the radiological design of the Mined Geologic Disposal System (MGDS) surface and subsurface facilities for the protection of workers, the public, and the environment. This document is intended to ensure that a common methodology is used by all groups that may be involved with Radiological Design. This document will also assist in ensuring the long term survivability of the information basis used for radiological safety design and will assist in satisfying the documentation requirements of the licensing body, the Nuclear Regulatory Commission (NRC). This design guide provides referenceable information that is current and maintained under the YMP Quality Assurance (QA) Program. Furthermore, this approach is consistent with maintaining continuity in spite of a changing design environment. This approach also serves to ensure common inter-disciplinary interpretation and application of data

  8. REPOSITORY RADIATION SHIELDING DESIGN GUIDE

    Energy Technology Data Exchange (ETDEWEB)

    M. Haas; E.M. Fortsch

    1997-09-12

    The scope of this document includes radiation safety considerations used in the design of facilities for the Yucca Mountain Site Characterization Project (YMP). The purpose of the Repository Radiation Shielding Design Guide is to document the approach used in the radiological design of the Mined Geologic Disposal System (MGDS) surface and subsurface facilities for the protection of workers, the public, and the environment. This document is intended to ensure that a common methodology is used by all groups that may be involved with Radiological Design. This document will also assist in ensuring the long term survivability of the information basis used for radiological safety design and will assist in satisfying the documentation requirements of the licensing body, the Nuclear Regulatory Commission (NRC). This design guide provides referenceable information that is current and maintained under the YMP Quality Assurance (QA) Program. Furthermore, this approach is consistent with maintaining continuity in spite of a changing design environment. This approach also serves to ensure common inter-disciplinary interpretation and application of data.

  9. Head Start Center Design Guide.

    Science.gov (United States)

    Administration for Children, Youth, and Families (DHHS), Washington, DC. Head Start Bureau.

    This guide contains suggested criteria for planning, designing, and renovating Head Start centers so that they are safe, child-oriented, developmentally appropriate, beautiful, environmentally sensitive, and functional. The content is based on the U.S. General Services Administration's Child Care Center Design Guide, PBS-P140, which was intended…

  10. Practical column design guide

    CERN Document Server

    Nitsche, M

    2017-01-01

    This book highlights the aspects that need to be considered when designing distillation columns in practice. It discusses the influencing parameters as well as the equations governing them, and presents several numerical examples. The book is intended both for experienced designers and for those who are new to the subject.

  11. Rock slope design guide.

    Science.gov (United States)

    2011-04-01

    This Manual is intended to provide guidance for the design of rock cut slopes, rockfall catchment, and : rockfall controls. Recommendations presented in this manual are based on research presented in Shakoor : and Admassu (2010) entitled Rock Slop...

  12. Interior Design: Teacher's Instructional Guide.

    Science.gov (United States)

    Hays, Tricia

    This teacher's instructional guide, which is part of a family and consumer sciences education series focusing on a broad range of employment opportunities, is intended to assist teachers responsible for teaching one- and two-year interior design programs for Texas high school students. The following are among the items included: (1) introductory…

  13. Students' guide to program design

    CERN Document Server

    Robertson, Lesley Anne

    1992-01-01

    Students' Guide to Program Design is a textbook on program design. This textbook approaches program design by using structures programming techniques and pseudocode to develop a solution algorithm. Divided into 10 chapters, the book begins with a basic explanation of structured programming techniques, top-down development, and modular design. This discussion is followed by detailed concepts of the syntax of pseudocode; methods of defining the problem; the application of basic control structures in the development of the solution algorithm; desk checking techniques; hierarchy charts; and module

  14. Energy Design Guides for Army Barracks: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Deru, M.; Zhivov, A.; Herron, D.

    2008-08-01

    The U.S. Army Corps of Engineers and NREL are developing target energy budgets and design guides to achieve 30% energy savings. This paper focuses the design guide for one type of barracks called unaccompanied enlisted personal housing.

  15. Energy and environment design guide

    Energy Technology Data Exchange (ETDEWEB)

    Harman, K. [Royal Australian Institute of Architects, Canberra, ACT (Australia)

    1996-04-01

    The Royal Australian Institute of Architects (RAIA) released an Environment Policy for architects in September 1994 which forms part of the RAIA Code of Professional Conduct. Prior to releasing the policy, it was recognised that members needed information and education in the area of energy and environment in order to adopt and implement the guide. This document is a report on the scope, work programme and achievements of a project to provide an easy reference resource for architects and other building designers, and bring together a wide range of information and research. It includes the Environment Policy as an appendix. The project produced 24 notes entitled the `Environment Design Guide - energy/environment notes` covering a wide range of topics, and four newsletters. Feedback received from architects to date indicates that the development of the notes has had a positive effect on their knowledge of these issues, resulting in the making of informed design decisions. The topics covered by the notes are expected to expand in 1996 with the preparation of additional notes which provide information on products and sustainable construction.

  16. The linear algebra survival guide illustrated with Mathematica

    CERN Document Server

    Szabo, Fred

    2015-01-01

    The Linear Algebra Survival Guide is a reference book with a free downloadable Mathematica notebook containing all of interactive code to make the content of the book playable in Mathematica and the Mathematica Player. It offers a concise introduction to the core topics of linear algebra which includes numerous exercises that will accompany a first or second course in linear algebra. This book will guide you through the powerful graphic displays and visualization of Mathematica that make the most abstract theories seem simple-- allowing you to tackle realistic problems using simple mathematic

  17. Graphic Design Career Guide 2. Revised Edition.

    Science.gov (United States)

    Craig, James

    The graphic design field is diverse and includes many areas of specialization. This guide introduces students to career opportunities in graphic design. The guide is organized in four parts. "Part One: Careers in Graphic Design" identifies and discusses the various segments of the graphic design industry, including: Advertising, Audio-Visual, Book…

  18. Algebra Survival Guide A Conversational Handbook for the Thoroughly Befuddled

    CERN Document Server

    Rappaport, Josh

    2011-01-01

    If you think algebra has to be boring, confusing and unrelated to anything in the real world, think again! Written in a humorous, conversational style, this book gently nudges students toward success in pre-algebra and Algebra I. With its engaging question/answer format and helpful practice problems, glossary and index, it is ideal for homeschoolers, tutors and students striving for classroom excellence. It features funky icons and lively cartoons by award-winning Santa Fe artist Sally BlakemoreThe Algebra Survival Guide is the winner of a Paretns' Choice award, and it meets the Standards 2000

  19. Survivability design for a hybrid underwater vehicle

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Biao; Wu, Chao; Li, Xiang; Zhao, Qingkai; Ge, Tong [State Key Lab of Ocean Engineering, School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai 200240 (China)

    2015-03-10

    A novel hybrid underwater robotic vehicle (HROV) capable of working to the full ocean depth has been developed. The battery powered vehicle operates in two modes: operate as an untethered autonomous vehicle in autonomous underwater vehicle (AUV) mode and operate under remote control connected to the surface vessel by a lightweight, fiber optic tether in remotely operated vehicle (ROV) mode. Considering the hazardous underwater environment at the limiting depth and the hybrid operating modes, survivability has been placed on an equal level with the other design attributes of the HROV since the beginning of the project. This paper reports the survivability design elements for the HROV including basic vehicle design of integrated navigation and integrated communication, emergency recovery strategy, distributed architecture, redundant bus, dual battery package, emergency jettison system and self-repairing control system.

  20. Survivability design for a hybrid underwater vehicle

    International Nuclear Information System (INIS)

    Wang, Biao; Wu, Chao; Li, Xiang; Zhao, Qingkai; Ge, Tong

    2015-01-01

    A novel hybrid underwater robotic vehicle (HROV) capable of working to the full ocean depth has been developed. The battery powered vehicle operates in two modes: operate as an untethered autonomous vehicle in autonomous underwater vehicle (AUV) mode and operate under remote control connected to the surface vessel by a lightweight, fiber optic tether in remotely operated vehicle (ROV) mode. Considering the hazardous underwater environment at the limiting depth and the hybrid operating modes, survivability has been placed on an equal level with the other design attributes of the HROV since the beginning of the project. This paper reports the survivability design elements for the HROV including basic vehicle design of integrated navigation and integrated communication, emergency recovery strategy, distributed architecture, redundant bus, dual battery package, emergency jettison system and self-repairing control system

  1. Experiment Design and Analysis Guide - Neutronics & Physics

    Energy Technology Data Exchange (ETDEWEB)

    Misti A Lillo

    2014-06-01

    The purpose of this guide is to provide a consistent, standardized approach to performing neutronics/physics analysis for experiments inserted into the Advanced Test Reactor (ATR). This document provides neutronics/physics analysis guidance to support experiment design and analysis needs for experiments irradiated in the ATR. This guide addresses neutronics/physics analysis in support of experiment design, experiment safety, and experiment program objectives and goals. The intent of this guide is to provide a standardized approach for performing typical neutronics/physics analyses. Deviation from this guide is allowed provided that neutronics/physics analysis details are properly documented in an analysis report.

  2. Aircraft Crash Survival Design Guide. Volume 5. Aircraft Postcrash Survival

    Science.gov (United States)

    1980-01-01

    neck Access door toprille capm enrFuel tank Figue 3. Fangblefiler eckinsalgbelati n. A-j L)n wal Aircraft skin Frangible filler neck Failure plane...This is because a number of major assumptions must be made in the extrapolation: the smoke generated is uniformly distri- buted and is independent

  3. Technical guide to criticality alarm system design

    International Nuclear Information System (INIS)

    Greenfield, B.

    2009-01-01

    An instructional manual was created to guide criticality safety engineers through the technical aspects of designing a criticality alarm system (CAS) for Dept. of Energy (DOE) hazard class 1 and 2 facilities. The manual was structured such that it can be used by engineers designing completely new systems and by those who are working with existing facilities. Major design tasks are thoroughly analyzed to provide concise direction for how to complete the analysis. Regulatory and technical performance requirements were both addressed. (authors)

  4. Interior Design 1992 Buyers Guide issue.

    Science.gov (United States)

    1992-01-30

    The Interior Design Magazine Buyers Guide is compiled with you, the designer, in mind. So it's packed with the most comprehensive collection of sources available anyplace--arranged for fast, easy access. First, the Keyword Index presents all the Buyers Guide product categories alphabetically (see the first tab divider). Refer to the page number indicated in the Product Index (second tab divider) to view various manufacturers of products under each category heading. Addresses, phone and fax numbers, regional and international showroom/representatives are located in the A-Z Index (third tab divider) in alphabetical order. Consult the table of contents for trade associations, lighting consultants, marts, and other useful sections.

  5. 50% Advanced Energy Design Guides: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Bonnema, E.; Leach, M.; Pless, S.; Liu, B.; Wang, W.; Thornton, B.; Williams, J.

    2012-07-01

    This paper presents the process, methodology, and assumptions for the development of the 50% Energy Savings Advanced Energy Design Guides (AEDGs), a design guidance document that provides specific recommendations for achieving 50% energy savings above the requirements of ANSI/ASHRAE/IESNA Standard 90.1-2004 in four building types: (1) Small to medium office buildings, (2) K-12 school buildings, (3) Medium to big box retail buildings, (4) Large hospital buildings.

  6. A guide to printed circuit board design

    CERN Document Server

    Hamilton, Charles

    1984-01-01

    A Guide to Printed Circuit Board Design discusses the basic design principles of printed circuit board (PCB). The book consists of nine chapters; each chapter provides both text discussion and illustration relevant to the topic being discussed. Chapter 1 talks about understanding the circuit diagram, and Chapter 2 covers how to compile component information file. Chapter 3 deals with the design layout, while Chapter 4 talks about preparing the master artworks. The book also covers generating computer aided design (CAD) master patterns, and then discusses how to prepare the production drawing a

  7. Demisability and survivability sensitivity to design-for-demise techniques

    Science.gov (United States)

    Trisolini, Mirko; Lewis, Hugh G.; Colombo, Camilla

    2018-04-01

    The paper is concerned with examining the effects that design-for-demise solutions can have not only on the demisability of components, but also on their survivability that is their capability to withstand impacts from space debris. First two models are introduced. A demisability model to predict the behaviour of spacecraft components during the atmospheric re-entry and a survivability model to assess the vulnerability of spacecraft structures against space debris impacts. Two indices that evaluate the level of demisability and survivability are also proposed. The two models are then used to study the sensitivity of the demisability and of the survivability indices as a function of typical design-for-demise options. The demisability and the survivability can in fact be influenced by the same design parameters in a competing fashion that is while the demisability is improved, the survivability is worsened and vice versa. The analysis shows how the design-for-demise solutions influence the demisability and the survivability independently. In addition, the effect that a solution has simultaneously on the two criteria is assessed. Results shows which, among the design-for-demise parameters mostly influence the demisability and the survivability. For such design parameters maps are presented, describing their influence on the demisability and survivability indices. These maps represent a useful tool to quickly assess the level of demisability and survivability that can be expected from a component, when specific design parameters are changed.

  8. When Nothing Matters Anymore: A Survival Guide for Depressed Teens.

    Science.gov (United States)

    Cobain, Bev

    This guide provides adolescents with information on depression. An introduction discusses symptoms of depression and lists famous people who were known to be depressed. Part 1, "What's Wrong," explores how it feels to be depressed, the causes and types of depression, and the connections between depression, suicide, and drug and alcohol abuse. A…

  9. Promoting, Guiding, and Surviving Change in School Districts.

    Science.gov (United States)

    Deal, Terrence E.; Nutt, Samuel C.

    Compiled for school administrators who must initiate or respond to external mandate for change, this guide draws on the experiences of 10 rural school districts that participated in the federally funded Experimental Schools (ES) program for perspectives that can be used in the successful management of change efforts in school districts. Organized…

  10. A pragmatic guide to multiphoton microscope design

    Science.gov (United States)

    Young, Michael D.; Field, Jeffrey J.; Sheetz, Kraig E.; Bartels, Randy A.; Squier, Jeff

    2016-01-01

    Multiphoton microscopy has emerged as a ubiquitous tool for studying microscopic structure and function across a broad range of disciplines. As such, the intent of this paper is to present a comprehensive resource for the construction and performance evaluation of a multiphoton microscope that will be understandable to the broad range of scientific fields that presently exploit, or wish to begin exploiting, this powerful technology. With this in mind, we have developed a guide to aid in the design of a multiphoton microscope. We discuss source selection, optical management of dispersion, image-relay systems with scan optics, objective-lens selection, single-element light-collection theory, photon-counting detection, image rendering, and finally, an illustrated guide for building an example microscope. PMID:27182429

  11. A Straight-Talk Survival Guide for Colleges

    Science.gov (United States)

    Facione, Peter A.

    2009-01-01

    Times are very tough. The great majority of colleges are looking at 2009 and 2010 and beyond, in anticipation of the deepest budget cuts in more than a generation. But as bad as the financial situation may be, colleges can survive if they take swift and strong emergency action. It is time for some straight talk, starting with the realization that…

  12. Guiding bioprocess design by microbial ecology.

    Science.gov (United States)

    Volmer, Jan; Schmid, Andreas; Bühler, Bruno

    2015-06-01

    Industrial bioprocess development is driven by profitability and eco-efficiency. It profits from an early stage definition of process and biocatalyst design objectives. Microbial bioprocess environments can be considered as synthetic technical microbial ecosystems. Natural systems follow Darwinian evolution principles aiming at survival and reproduction. Technical systems objectives are eco-efficiency, productivity, and profitable production. Deciphering technical microbial ecology reveals differences and similarities of natural and technical systems objectives, which are discussed in this review in view of biocatalyst and process design and engineering strategies. Strategies for handling opposing objectives of natural and technical systems and for exploiting and engineering natural properties of microorganisms for technical systems are reviewed based on examples. This illustrates the relevance of considering microbial ecology for bioprocess design and the potential for exploitation by synthetic biology strategies. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. ALS beamline design requirements: A guide for beamline designers

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-06-01

    This manual is written as a guide for researchers in designing beamlines and endstations acceptable for use at the ALS. It contains guidelines and policies related to personnel safety and equipment and vacuum protection. All equipment and procedures must ultimately satisfy the safety requirements set aside in the Lawrence Berkeley National Laboratory (LBNL) Health and Safety Manual (PUB-3000) which is available from the ALS User Office or on the World WideWeb from the LBNL Homepage (http:// www.lbl.gov).

  14. jQuery for designers beginner's guide

    CERN Document Server

    MacLees, Natalie

    2014-01-01

    A step-by-step guide that spices up your web pages and designs them in the way you want using the most widely used JavaScript library, jQuery. The beginner-friendly and easy-to-understand approach of the book will help get to grips with jQuery in no time. If you know the fundamentals of HTML and CSS, and want to extend your knowledge by learning to use JavaScript, then this is just the book for you. jQuery makes JavaScript straightforward and approachable - you'll be surprised at how easy it can be to add animations and special effects to your beautifully designed pages.

  15. Design guides for radioactive-material-handling facilities and equipment

    International Nuclear Information System (INIS)

    Doman, D.R.; Barker, R.E.

    1980-01-01

    Fourteen key areas relating to facilities and equipment for handling radioactive materials involved in examination, reprocessing, fusion fuel handling and remote maintenance have been defined and writing groups established to prepare design guides for each areas. The guides will give guidance applicable to design, construction, operation, maintenance and safety, together with examples and checklists. Each guide will be reviewed by an independent review group. The guides are expected to be compiled and published as a single document

  16. Vision Guided Intelligent Robot Design And Experiments

    Science.gov (United States)

    Slutzky, G. D.; Hall, E. L.

    1988-02-01

    The concept of an intelligent robot is an important topic combining sensors, manipulators, and artificial intelligence to design a useful machine. Vision systems, tactile sensors, proximity switches and other sensors provide the elements necessary for simple game playing as well as industrial applications. These sensors permit adaption to a changing environment. The AI techniques permit advanced forms of decision making, adaptive responses, and learning while the manipulator provides the ability to perform various tasks. Computer languages such as LISP and OPS5, have been utilized to achieve expert systems approaches in solving real world problems. The purpose of this paper is to describe several examples of visually guided intelligent robots including both stationary and mobile robots. Demonstrations will be presented of a system for constructing and solving a popular peg game, a robot lawn mower, and a box stacking robot. The experience gained from these and other systems provide insight into what may be realistically expected from the next generation of intelligent machines.

  17. Oracle Database 12c backup and recovery survival guide

    CERN Document Server

    Alvarez, Francisco Munoz

    2013-01-01

    The book follows a tutorial-based approach, covering all the best practices for backup and recovery. The book starts by introducing readers to the world of backup and recovery, then moves on to teach them the new features offered by Oracle 12c. The book is full of useful tips and best practices that are essential for any DBA to perform backup and recovery operations in an organization.This book is designed for Oracle DBAs and system administrators. The reader will have a basic working experience of administering Oracle databases. This book is designed for Oracle DBAs and system administrators.

  18. Embroidered Electromyography: A Systematic Design Guide.

    Science.gov (United States)

    Shafti, Ali; Ribas Manero, Roger B; Borg, Amanda M; Althoefer, Kaspar; Howard, Matthew J

    2017-09-01

    Muscle activity monitoring or electromyography (EMG) is a useful tool. However, EMG is typically invasive, expensive and difficult to use for untrained users. A possible solution is textile-based surface EMG (sEMG) integrated into clothing as a wearable device. This is, however, challenging due to 1) uncertainties in the electrical properties of conductive threads used for electrodes, 2) imprecise fabrication technologies (e.g., embroidery, sewing), and 3) lack of standardization in design variable selection. This paper, for the first time, provides a design guide for such sensors by performing a thorough examination of the effect of design variables on sEMG signal quality. Results show that imprecisions in digital embroidery lead to a trade-off between low electrode impedance and high manufacturing consistency. An optimum set of variables for this trade-off is identified and tested with sEMG during a variable force isometric grip exercise with n = 12 participants, compared with conventional gel-based electrodes. Results show that thread-based electrodes provide a similar level of sensitivity to force variation as gel-based electrodes with about 90% correlation to expected linear behavior. As proof of concept, jogging leggings with integrated embroidered sEMG are made and successfully tested for detection of muscle fatigue while running on different surfaces.

  19. The design and analysis of salmonid tagging studies in the Columbia Basin. Volume 10: Instructional guide to using program CaptHist to create SURPH files for survival analysis using PTAGIS data files

    International Nuclear Information System (INIS)

    Westhagen, P.; Skalski, J.

    1997-12-01

    The SURPH program is a valuable tool for estimating survivals and capture probabilities of fish outmigrations on the Snake and Columbia Rivers. Using special data files, SURPH computes reach to reach statistics for any release group passing a system of detection sites. Because the data must be recorded for individual fish, PIT tag data is best suited for use as input. However, PIT tag data as available from PTAGIS comes in a form that is not ready for use as SURPH input. SURPH requires a capture history for each fish. A capture history consists of a series of fields, one for each detection site, that has a code for whether the fish was detected and returned to the river, detected and removed, or not detected. For the PTAGIS data to be usable by SURPH it must be pre-processed. The data must be condensed down to one line per fish with the relevant detection information from the PTAGIS file represented compactly on each line. In addition, the PTAGIS data file coil information must be passed through a series of logic algorithms to determine whether or not a fish is returned to the river after detection. Program CaptHist was developed to properly pre-process the PTAGIS data files for input to program SURPH. This utility takes PTAGIS data files as input and creates a SURPH data file as well as other output including travel time records, detection date records, and a data error file. CaptHist allows a user to download PTAGIS files and easily process the data for use with SURPH

  20. Using IMPRINT to Guide Experimental Design with Simulated Task Environments

    Science.gov (United States)

    2015-06-18

    USING IMPRINT TO GUIDE EXPERIMENTAL DESIGN OF SIMULATED TASK ENVIRONMENTS THESIS Gregory...ENG-MS-15-J-052 USING IMPRINT TO GUIDE EXPERIMENTAL DESIGN WITH SIMULATED TASK ENVIRONMENTS THESIS Presented to the Faculty Department...Civilian, USAF June 2015 DISTRIBUTION STATEMENT A. APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED. AFIT-ENG-MS-15-J-052 USING IMPRINT

  1. Design Guide for Category I reactors critical facilities

    International Nuclear Information System (INIS)

    Brynda, W.J.; Powell, R.W.

    1978-08-01

    The purpose of this Design Guide is to provide additional guidance to aid the DOE facility contractor in meeting the requirement that the siting, design, construction, modification, operation, maintenance, and decommissioning of DOE-owned critical facilities be in accordance with generally uniform standards, guides, and codes which are comparable to those applied to similar reactors licensed by the Nuclear Regulatory Commission

  2. Design for Survivability: An Approach to Assured Autonomy

    Science.gov (United States)

    Alexandrov, Natalia M.; Ozoroski, Thomas A.

    2016-01-01

    Rapidly expanding unmanned air traffic includes and will continue to include non-cooperative participants. Non-cooperative behavior may be due to technical failure, a lack of appropriate equipment, a careless or malicious operator. Regardless of the cause, the outcome remains: growing density of non-cooperative traffic will increase the risk of collision between unmanned vehicles and aircraft carrying humans. As a result, the degraded safety of airspace may limit access to airspace, with adverse consequences for the traveling public and the economy. Because encounters with small non-cooperative objects, such as birds or wayward drones, can happen too rapidly for an external control system to mitigate them, it is imperative that the aircraft that carry humans survive encounters with non-cooperative vehicles. To-date, design for survivability has been practiced explicitly in the military domain. Survivability against collisions in civil aviation has been limited to tolerances against bird strikes; and these tolerances have proved inadequate on occasion. The growing risk of collision with unmanned vehicles now requires the development of survivability discipline for civilian transport aircraft. The new discipline must be infused into multidisciplinary design methods, on par with traditional disciplines. In this paper, we report on a preliminary study of survivability considerations for the civil aviation domain.

  3. Safety design guides for fire protection for CANDU 9

    International Nuclear Information System (INIS)

    Lee, Duk Su; Chang, Woo Hyun; Lee, Nam Young; A. C. D. Wright

    1996-03-01

    This safety design guide establishes design requirements to ensure the radiological risk to the public due to fire is acceptable and operating personnel are adequately protected from the hazards of fires. This safety design guide also specifies the safety criteria for fire protection to be applied to mitigate fires and recommends the fire protection program to be established to initiate, coordinate and document the design activities associated with fire protection. The requirements for fire protection outlined in this safety design guide shall be satisfied in the design stage and the change status of the regulatory requirements, code and standards should be traced and incorporated into this safety design guide accordingly. 1 fig., (Author) .new

  4. Analog circuit design a tutorial guide to applications and solutions

    CERN Document Server

    Williams, Jim

    2011-01-01

    * Covers the fundamentals of linear/analog circuit and system design to guide engineers with their design challenges. * Based on the Application Notes of Linear Technology, the foremost designer of high performance analog products, readers will gain practical insights into design techniques and practice. * Broad range of topics, including power management tutorials, switching regulator design, linear regulator design, data conversion, signal conditioning, and high frequency/RF design. * Contributors include the leading lights in analog design, Robert Dobkin, Jim Willia

  5. Safety design guides for containment extension for CANDU 9

    International Nuclear Information System (INIS)

    Lee, Duk Su; Chang, Woo Hyun; Lee, Nam Young; A. C. D. Wright

    1996-03-01

    This safety design guide for containment extension describes the containment isolation philosophy and containment extension requirements. The metal extensions and components falling within the scope of ASME Section III are classified in accordance with the CAN/CSA-N285.0 and CAN/CSA-N285.3. The special consideration for the leak monitoring capability, seismic qualification and inspection requirements for containment extensions, etc., are defined in this design guide. In addition, the containment isolation systems are defined and summarized schematically in appendix A. The change status of the regulatory requirements, code and standards should be traced and this safety design guide shall be updated accordingly. (Author) .new

  6. WWC Study Review Guide: Group Design Studies

    Science.gov (United States)

    What Works Clearinghouse, 2018

    2018-01-01

    Underlying all What Works Clearinghouse (WWC) products are WWC Study Review Guides, which are intended for use by WWC certified reviewers to assess studies against the WWC evidence standards. As part of an ongoing effort to increase transparency, promote collaboration, and encourage widespread use of the WWC standards, the Institute of Education…

  7. How design guides learning from matrix diagrams

    NARCIS (Netherlands)

    van der Meij, Jan; Amelsvoort, Marije; Anjewierden, Anjo

    2017-01-01

    Compared to text, diagrams are superior in their ability to structure and summarize information and to show relations between concepts and ideas. Perceptual cues, like arrows, are expected to improve the retention of diagrams by guiding the learner towards important elements or showing a preferred

  8. How Design Guides Learning from Matrix Diagrams

    Science.gov (United States)

    van der Meij, Jan; van Amelsvoort, Marije; Anjewierden, Anjo

    2017-01-01

    Compared to text, diagrams are superior in their ability to structure and summarize information and to show relations between concepts and ideas. Perceptual cues, like arrows, are expected to improve the retention of diagrams by guiding the learner towards important elements or showing a preferred reading sequence. In our experiment, we analyzed…

  9. Active and passive beam application design guide for global application

    CERN Document Server

    Rimmer, Julian

    2015-01-01

    The Active and Passive Beam Application Design Guide is the result of collaboration by worldwide experts to give system designers a current, authoritative guide on successfully applying active and passive beam technology. Active and Passive Beam Application Design Guide provide energy-efficient methods of cooling, heating, and ventilating indoor areas, especially spaces that require individual zone control and where internal moisture loads are moderate. The systems are simple to operate, with low maintenance requirements. This book is an essential resource for consulting engineers, architects, owners, and contractors who are involved in the design, operation, and installation of these systems. Building on REHVA’s Chilled Beam Application Guidebook, this new guide provides up-to-date tools and advice for designing, commissioning, and operating chilled-beam systems to achieve a determined indoor climate, and includes examples of active and passive beam calculations and selections. Dual units (SI and I-P) are...

  10. Usability Testing, User-Centered Design, and LibGuides Subject Guides: A Case Study

    Science.gov (United States)

    Sonsteby, Alec; DeJonghe, Jennifer

    2013-01-01

    Usability testing has become a routine way for many libraries to ensure that their Web presence is user-friendly and accessible. At the same time, popular subject guide creation systems, such as LibGuides, decentralize Web content creation and put authorship into the hands of librarians who may not be trained in user-centered design principles. At…

  11. Terminal Sliding Mode Tracking Controller Design for Automatic Guided Vehicle

    Science.gov (United States)

    Chen, Hongbin

    2018-03-01

    Based on sliding mode variable structure control theory, the path tracking problem of automatic guided vehicle is studied, proposed a controller design method based on the terminal sliding mode. First of all, through analyzing the characteristics of the automatic guided vehicle movement, the kinematics model is presented. Then to improve the traditional expression of terminal sliding mode, design a nonlinear sliding mode which the convergence speed is faster than the former, verified by theoretical analysis, the design of sliding mode is steady and fast convergence in the limited time. Finally combining Lyapunov method to design the tracking control law of automatic guided vehicle, the controller can make the automatic guided vehicle track the desired trajectory in the global sense as well as in finite time. The simulation results verify the correctness and effectiveness of the control law.

  12. Design basis ground motion (Ss) required on new regulatory guide

    International Nuclear Information System (INIS)

    Kamae, Katsuhiro

    2013-01-01

    New regulatory guide is enforced on July 8. Here, it is introduced how the design basis ground motion (Ss) for seismic design of nuclear power reactor facilities was revised on the new guide. Ss is formulated as two types of earthquake ground motions, earthquake ground motions with site specific earthquake source and with no such specific source locations. The latter is going to be revised based on the recent observed near source ground motions. (author)

  13. Design guide for Category III reactors: pool type reactors

    International Nuclear Information System (INIS)

    Brynda, W.J.; Lobner, P.R.; Powell, R.W.; Straker, E.A.

    1978-11-01

    The Department of Energy (DOE) in the ERDA Manual requires that all DOE-owned reactors be sited, designed, constructed, modified, operated, maintained, and decommissioned in a manner that gives adequate consideration to health and safety factors. Specific guidance pertinent to the safety of DOE-owned reactors is found in Chapter 0540 of the ERDA Manual. The purpose of this Design Guide is to provide additional guidance to aid the DOE facility contractor in meeting the requirement that the siting, design, construction, modification, operation, maintenance, and decommissioning of DOE-owned reactors be in accordance with generally uniform standards, guides, and codes which are comparable to those applied to similar reactors licensed by the Nuclear Regulatory Commission (NRC). This Design Guide deals principally with the design and functional requirement of Category III reactor structures, components, and systems

  14. K-12 Local Network (LAN) Design Guide

    National Research Council Canada - National Science Library

    Horton, Cody

    1998-01-01

    ...) educators preparing to design and implement LANs in K-12 schools and libraries. Data was collected during the implementation of LANs in K-12 schools of the Monterey Peninsula Uniform School District (MPUSD...

  15. Radiological containment selection, design, and specification guide

    International Nuclear Information System (INIS)

    Brown, R.L.

    1994-01-01

    This document provides guidance to Tank Waste Remediation Systems personnel in determining what containment is appropriate for work activities, what containments are available, general applications of each, design criteria, and other information needed to make informed decisions concerning containment application

  16. Learning design guided learning analytics in MOOCs

    NARCIS (Netherlands)

    Brouns, Francis; Firssova, Olga

    2016-01-01

    Poster presentation for our paper Brouns, F., & Firssova, O. (2016, October).The role of learning design and learning analytics in MOOCs. Paper presented at 9th EDEN Research Workshop, Oldenburg, Germany.

  17. Safety design guides for seismic requirements for CANDU 9

    International Nuclear Information System (INIS)

    Lee, Duk Su; Chang, Woo Hyun; Lee, Nam Young; A. C. D. Wright

    1996-03-01

    This safety design guide for seismic requirements for CANDU 9 describes the seismic design philosophy, defines the applicable earthquakes and identifies the structures and systems requiring seismic qualification to ensure that the essential safety function can be adequately satisfied following earthquake. The detailed requirements for structures, systems and components which must be seismically qualified are specified in the Appendix. The change status of the regulatory requirements, code and standards should be traced and this safety design guide shall be updated accordingly. 1 fig., (Author) .new

  18. Guide for the realization of Design Base Documents (DBD)

    International Nuclear Information System (INIS)

    Roca Mallofre, G. la

    2010-01-01

    Guide for improving the consistency and quality content of the Design Base Documents. It's a short description of how to carry out and complete these Documents but focusing on those aspects that can be more confusing and harder to interpret. This guide aims to clarify the term Design Base distinguishing between production and safety, and it focuses on safety Design Base Documents and their values and references. It also emphasizes the difference between the support system and the interface system when there is a functional connection between different systems.

  19. Design guide for calculating fluid damping for circular cylindrical structures

    International Nuclear Information System (INIS)

    Chen, S.S.

    1983-06-01

    Fluid damping plays an important role for structures submerged in fluid, subjected to flow, or conveying fluid. This design guide presents a summary of calculational procedures and design data for fluid damping for circular cylinders vibrating in quiescent fluid, crossflow, and parallel flow

  20. A design guide for energy-efficient research laboratories

    Energy Technology Data Exchange (ETDEWEB)

    Wishner, N.; Chen, A.; Cook, L. [eds.; Bell, G.C.; Mills, E.; Sartor, D.; Avery, D.; Siminovitch, M.; Piette, M.A.

    1996-09-24

    This document--A Design Guide for Energy-Efficient Research Laboratories--provides a detailed and holistic framework to assist designers and energy managers in identifying and applying advanced energy-efficiency features in laboratory-type environments. The Guide fills an important void in the general literature and compliments existing in-depth technical manuals. Considerable information is available pertaining to overall laboratory design issues, but no single document focuses comprehensively on energy issues in these highly specialized environments. Furthermore, practitioners may utilize many antiquated rules of thumb, which often inadvertently cause energy inefficiency. The Guide helps its user to: introduce energy decision-making into the earliest phases of the design process, access the literature of pertinent issues, and become aware of debates and issues on related topics. The Guide does focus on individual technologies, as well as control systems, and important operational factors such as building commissioning. However, most importantly, the Guide is intended to foster a systems perspective (e.g. right sizing) and to present current leading-edge, energy-efficient design practices and principles.

  1. Lighting [A guide to ecological design

    CSIR Research Space (South Africa)

    Osburn, L

    2009-02-01

    Full Text Available Lighting consumes between about 29-35% of the energy used within commercial office space while lighting only consumes about 11% of the energy used in a residential environment. Through conscientious design of the lighting systems, the lighting load...

  2. CAM and stack air sampler design guide

    International Nuclear Information System (INIS)

    Phillips, T.D.

    1994-01-01

    About 128 air samplers and CAMs presently in service to detect and document potential radioactive release from 'H' and 'F' area tank farm ventilation stacks are scheduled for replacement and/or upgrade by Projects S-5764, S-2081, S-3603, and S-4516. The seven CAMs scheduled to be upgraded by Project S-4516 during 1995 are expected to provide valuable experience for the three remaining projects. The attached document provides design guidance for the standardized High Level Waste air sampling system

  3. Magnetic resonance image-guided brachytherapy for cervical cancer. Prognostic factors for survival

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yeon-Joo; Kim, Joo-Young [National Cancer Center, Proton Therapy Center, Goyang (Korea, Republic of); National Cancer Center, Center for Uterine Cancer, Goyang (Korea, Republic of); Kim, Youngkyong; Lim, Young Kyung; Jeong, Jonghwi [National Cancer Center, Proton Therapy Center, Goyang (Korea, Republic of); Jeong, Chiyoung [National Cancer Center, Proton Therapy Center, Goyang (Korea, Republic of); University of Ulsan College of Medicine, Department of Radiation Oncology, Asan Medical Center, Seoul (Korea, Republic of); Kim, Meyoung [National Cancer Center, Proton Therapy Center, Goyang (Korea, Republic of); Dongnam Inst. of Radiology and Medical Sciences, Research center, Busan (Korea, Republic of); Lim, Myong Cheol; Seo, Sang-Soo; Park, Sang-Yoon [National Cancer Center, Center for Uterine Cancer, Goyang (Korea, Republic of)

    2016-12-15

    The purpose of this work was to identify prognostic factors for survival after magnetic resonance image (MRI)-guided brachytherapy combined with external beam radiotherapy for cervical cancer. External beam radiotherapy of 45-50.4 Gy was delivered by either three-dimensional conformal radiotherapy or helical tomotherapy. Patients also received high-dose-rate MRI-guided brachytherapy of 5 Gy in 6 fractions. We analyzed 128 patients with International Federation of Gynecology and Obstetrics stage IB-IVB cervical cancer who underwent MRI-guided brachytherapy. Most patients (96 %) received concurrent chemotherapy. Pelvic lymph node metastases and para-aortic lymphadenopathies were found in 62 % and 14 % of patients, respectively. The median follow-up time was 44 months. Complete remission was achieved in 119 of 128 patients (93 %). The 5-year local recurrence-free, cancer-specific, and overall survival rates were 94, 89, and 85 %, respectively. Negative pelvic lymphadenopathy, gross tumor volume (GTV) dose covering 90 % of the target (GTV D90) of >110 Gy, and treatment duration ≤56 days were associated with better overall survival in univariate analyses. Multivariable analysis showed that GTV D90 of >110 Gy and treatment duration ≤56 days were possibly associated with overall survival with near-significant P-values of 0.062 and 0.073, respectively. The outcome of MRI-guided brachytherapy combined with external beam radiotherapy in patients with cervical cancer was excellent. GTV D90 of >110 Gy and treatment duration ≤56 days were potentially associated with overall survival. (orig.) [German] Ziel der Arbeit war es, prognostische Faktoren nach magnetresonanztomographisch (MRT-)gesteuerter Brachytherapie in Verbindung mit externer Strahlentherapie fuer Gebaermutterhalskrebs zu identifizieren. Externe Strahlentherapie von 45-50,4 Gy erfolgte entweder mittels dreidimensionaler konformaler Strahlentherapie oder helikaler Tomotherapie. Die Patientinnen erhielten auch

  4. DOT-7A Type A packaging design guide

    International Nuclear Information System (INIS)

    Kelly, D.L.

    1995-01-01

    The purpose of this Design Guide is to provide instruction for designing a U.S. Department of Transportation Specification 7A (DOT-7A) Type A packaging. Another purpose for this Design Guide is to support the evaluation and testing activities that are performed on new designs by a U.S. Department of Energy (DOE) test facility. This evaluation and testing program is called the DOT-7A Program. When an applicant has determined that a DOT-7A packaging is needed and not commercially available, a design may be created according to this document. The design should include a packaging drawing, specifications, analysis report, operating instructions, and a Packaging Qualification Checklist; all of which should be forwarded to a DOE/HQ approved test facility for evaluation and testing. This report is being submitted through the Engineering Documentation System so that it may be used for reference and information purposes

  5. [Participatory design guide for mental health promotion in prisons].

    Science.gov (United States)

    Bustamante Navarro, R; Paredes-Carbonell, J J; Aviñó Juan-Ulpiano, D; González Rubio, J; Pitarch Monzó, C; Martínez Martínez, L; Arroyo-Cobo, J M

    2013-01-01

    [corrected] The main aim was to describe the issues and the participatory process required to design a Guide to promotemental health in prison through group activities. We reviewed the bibliography, the mental health policies, the workshops about healthy mental habits, and a video about protection and risk factors. We identified the stakeholders and sought their points of view about the topics included in the Guide. We decided on the contents of the Guide and the incorporation of the health assets model and the perspectives provided by gender and cultural diversity. After the initial design of the modules and sessions, we started a pilot in the Prison of Valencia and the Prison of Zaragoza with women and men from different cultures, incorporating the suggested improvements, unifying contents and the discursive style. The guide is formed by: a preface, introduction, description, modules, sessions and evaluation. It has 6 modules and 19 sessions on: health and motivation; self-esteem; health and emotions; more assets to improve health: relax, positive thinking, keeping calm, communication and problem resolution; progress is possible: resiliency and starring in my own change. Each session consists of: activities (objectives, material, allocated time and development), theoretical material and tabbed sheets for activities. The guide is available in print and online versions. A guide has been elaborated with involved stakeholders and the opinion of the prison population.

  6. Safety design guide for pipe rupture protection for CANDU 9

    International Nuclear Information System (INIS)

    Lee, Duk Su; Chang, Woo Hyun; Lee, Nam Young; A. C. D. Wright

    1996-03-01

    This safety design guide for pipe rupture protection identifies high-energy systems in which pipe ruptures must be postulated to occur, as well as systems that must be protected from the dynamic effects of such ruptures. Dynamic effects considered in this SDG consist of pipe whip (including missiles generated by pipe ruptures, if any) and jet impingement, Requirements for protection against the dynamic effects of a postulated pipe rupture and method of protection of essential structures, systems and components are specified for these effects. The change status for the regulatory requirements, code and standards should be traced and this safety design guide shall be updated accordingly. 2 tabs., 5 refs. (Author) .new

  7. Design and tests of an adaptive focusing neutron guide

    International Nuclear Information System (INIS)

    Valicu, Roxana Georgiana

    2012-01-01

    This work contains the Monte Carlo Simulations, as well as the first tests with an adaptive focusing neutron guide for creating a focus that does not depend on the wavelength of the incoming neutrons. All known neutron guides consist of a rectangular shape, built out of four glass plates. The inner side of the guide is coated with a complex structure of metal layers. This reflects and guides the neutrons (in analogy with the reflection of the light). For beam focusing neutron guides with fixed curvature can be built. For most experiments it is important that the beam is focused on to a small surface of the sample. In the case of focusing guides with fixed curvature it has been observed that the focusing (dimension and position of the beam focus) is wavelength dependent. This is why for measurements that are performed with different wavelengths it is very important to change the curvature of the neutron guide in order to obtain optimal results. In this work we have designed, constructed and tested a guide where we can change the curvature during the experiment. In this way we can obtain a variable curvature in horizontal as well as in vertical direction. For a curvature in the horizontal or vertical direction it is not necessary to move all four walls, only two of the opposed plates. The element that changes the curvature of the guide consists of an acting element (piezomotor) as well as a rod that can be operated by the piezomotor and that acts through a lever onto the plate. The action of a force and a consecutive torsion momentum at the free end of the plate changes the curvature of the whole plate in an almost parabolic way. Making use of the Monte Carlo simulations we were able to determine the optimal curvature for each wavelength of a neutron guide for the spectrometer TOFTOF installed at the Forschungsneutronenquelle Heinz Maier-Leibnitz (FRM II). First tests have shown that with an adaptive focusing guide one can gain up to a factor three in intensity at

  8. Design and tests of an adaptive focusing neutron guide

    Energy Technology Data Exchange (ETDEWEB)

    Valicu, Roxana Georgiana

    2012-08-23

    This work contains the Monte Carlo Simulations, as well as the first tests with an adaptive focusing neutron guide for creating a focus that does not depend on the wavelength of the incoming neutrons. All known neutron guides consist of a rectangular shape, built out of four glass plates. The inner side of the guide is coated with a complex structure of metal layers. This reflects and guides the neutrons (in analogy with the reflection of the light). For beam focusing neutron guides with fixed curvature can be built. For most experiments it is important that the beam is focused on to a small surface of the sample. In the case of focusing guides with fixed curvature it has been observed that the focusing (dimension and position of the beam focus) is wavelength dependent. This is why for measurements that are performed with different wavelengths it is very important to change the curvature of the neutron guide in order to obtain optimal results. In this work we have designed, constructed and tested a guide where we can change the curvature during the experiment. In this way we can obtain a variable curvature in horizontal as well as in vertical direction. For a curvature in the horizontal or vertical direction it is not necessary to move all four walls, only two of the opposed plates. The element that changes the curvature of the guide consists of an acting element (piezomotor) as well as a rod that can be operated by the piezomotor and that acts through a lever onto the plate. The action of a force and a consecutive torsion momentum at the free end of the plate changes the curvature of the whole plate in an almost parabolic way. Making use of the Monte Carlo simulations we were able to determine the optimal curvature for each wavelength of a neutron guide for the spectrometer TOFTOF installed at the Forschungsneutronenquelle Heinz Maier-Leibnitz (FRM II). First tests have shown that with an adaptive focusing guide one can gain up to a factor three in intensity at

  9. The designer's guide to Verilog-AMS

    CERN Document Server

    Kundert, Kenneth S

    2004-01-01

    The Verilog Hardware Description Language (Verilog-HDL) has long been the most popular language for describing complex digital hardware. It started life as a prop- etary language but was donated by Cadence Design Systems to the design community to serve as the basis of an open standard. That standard was formalized in 1995 by the IEEE in standard 1364-1995. About that same time a group named Analog Verilog International formed with the intent of proposing extensions to Verilog to support analog and mixed-signal simulation. The first fruits of the labor of that group became available in 1996 when the language definition of Verilog-A was released. Verilog-A was not intended to work directly with Verilog-HDL. Rather it was a language with Similar syntax and related semantics that was intended to model analog systems and be compatible with SPICE-class circuit simulation engines. The first implementation of Verilog-A soon followed: a version from Cadence that ran on their Spectre circuit simulator. As more impleme...

  10. Signage and wayfinding design a complete guide to creating environmental graphic design systems

    CERN Document Server

    Calori, Chris

    2015-01-01

    A new edition of the market-leading guide to signage and wayfinding design This new edition of Signage and Wayfinding Design: A Complete Guide to Creating Environmental Graphic Design Systems has been fully updated to offer you the latest, most comprehensive coverage of the environmental design process-from research and design development to project execution. Utilizing a cross-disciplinary approach that makes the information relevant to architects, interior designers, landscape architects, graphic designers, and industrial engineers alike, the book arms you with the skills needed to apply a

  11. Development of Secondary Route Bridge Design Plan Guides

    Science.gov (United States)

    2018-03-03

    The objective of this study is to develop a set of bridge plan guides for low-volume traffic roads. The purpose of the plans is to facilitate construction of new structures suitable for local agencies. The designs are to specifically address common l...

  12. Study Design and Data Gathering Guide for Serious Games’ Evaluation

    NARCIS (Netherlands)

    Baalsrud Hauge, Jannicke; Boyle, Elizabeth; Mayer, Igor; Nadolski, Rob; Riedel, Johann C. K. H.; Moreno-Ger, Pablo; Bellotti, Francesco; Lim, Theodore; Ritchie, James

    2013-01-01

    Baalsrud Hauge, J., Boyle, E., Mayer, I., Nadolski, R. J., Riedel, J. C. K. H., Moreno-Ger, P., Bellotti, F., Lim, T., & Ritchie, J. (2013). Study Design and Data Gathering Guide for Serious Games’ Evaluation. In T. M. Connolly, T. Hainey, E. Boyle, G. Baxter, & P. Moreno-Ger (Eds.), Psychology,

  13. Best Practices Guide for Energy-Efficient Data Center Design

    Energy Technology Data Exchange (ETDEWEB)

    O. VanGeet: NREL

    2010-02-24

    This guide provides an overview of best practices for energy-efficient data center design which spans the categories of Information Technology (IT) systems and their environmental conditions, data center air management, cooling and electrical systems, on-site generation, and heat recovery.

  14. Distinctive Design A Practical Guide to a Useful, Beautiful Web

    CERN Document Server

    Dawson, Alexander

    2011-01-01

    Learn to produce a web site that stands out from the crowd One of the web designer's greatest challenges is to create a site distinctive enough to get noticed among the millions of sites already on the web. This book examines the bond between code, content and visuals to guide you through the factors that increase your design's visibility, usability and beauty. Using this practical advice, even web designers who lack strong artistic skills can develop super sites that strengthen the message and stand out from the crowd.Most books focus primarily on graphic design principles; this one shows you

  15. Stationary battery guide: Design, application, and maintenance. Final report

    International Nuclear Information System (INIS)

    1997-11-01

    This guide has been prepared to assist a variety of users with stationary battery design, application, and maintenance. The following battery-related topics are discussed in detail: (1) fundamentals--how batteries are designed and how they work; (2) aging, degradation, and failures with an emphasis on how various maintenance tasks can prevent, detect, or repair certain degradation mechanisms; (3) applications--how batteries are designed for a specific purpose and how the battery industry has evolved; (4) sizing for different applications; (5) protection and charging; (6) periodic inspections and checks; (7) capacity discharge testing; (8) installation and replacement considerations; and (9) problems that can occur with battery systems. Since the original guide was published, new IEEE Recommended Practices related to stationary battery applications have been issued. This revision addresses those industry changes as well as some of the emerging issues related to the development of other industry documents. This guide has been prepared as a comprehensive reference source for stationary batteries and is intended to address the design, application, and maintenance needs of users. The technical discussions are at the application level. Fundamentals of battery design are covered in greater detail in this revision. More details related to internal cell materials, their operational relationship, and performance over the expected life of the battery cell are provided. This information has been included because many changes in battery cell materials, manufacturing and design processes are not always communicated to the user

  16. Designing and conducting survey research a comprehensive guide

    CERN Document Server

    Rea, Louis M

    2014-01-01

    The industry standard guide, updated with new ideas and SPSS analysis techniques Designing and Conducting Survey Research: A Comprehensive Guide Fourth Edition is the industry standard resource that covers all major components of the survey process, updated to include new data analysis techniques and SPSS procedures with sample data sets online. The book offers practical, actionable guidance on constructing the instrument, administrating the process, and analyzing and reporting the results, providing extensive examples and worksheets that demonstrate the appropriate use of survey and data tech

  17. Safety design guides for environmental qualification for CANDU 9

    International Nuclear Information System (INIS)

    Lee, Duk Su; Chang, Woo Hyun; Lee, Nam Young; A. C. D. Wright

    1996-03-01

    This safety design guide describes the safety philosophy and requirements for the environmental qualification of safety related systems and components for CANDU 9. The environmental qualification program identifies the equipments to be qualified and conditions to be used for qualification and provides comprehensive set of documentation to ensure that the qualification is complete and can be maintained for the life of the plant. A summary of the system, components and structures requiring environmental qualification is provided in the table for the guidance of the system design, and this table will be subject to change or confirmation by the environmental qualification program. Also, plant ares subject to harsh environment is provided in the figure. The change status of the regulatory requirements, code and standards should be traced and this safety design guide shall be updated accordingly. 1 tab., 5 figs. (Author) .new

  18. GIS cartography a guide to effective map design

    CERN Document Server

    Peterson, Gretchen N

    2009-01-01

    Maps, either printed or digital, can create effective communication with bosses, clients, other scientists, and the public. However, entry level GISers often find that map design was given short shrift in their pre-professional life. It is time for the GIS field, which is maturing in other ways, to improve its skills in this area. Based on the author's more than ten years of research and practice in map design, GIS Cartography: A Guide to Effective Map Design provides the tools to create truly sophisticated maps. Packed full of in-depth information and advice, this book covers all facets of ma

  19. CMOS sigma-delta converters practical design guide

    CERN Document Server

    De la Rosa, Jose M

    2013-01-01

    A comprehensive overview of Sigma-Delta Analog-to-Digital Converters (ADCs) and a practical guide to their design in nano-scale CMOS for optimal performance. This book presents a systematic and comprehensive compilation of sigma-delta converter operating principles, the new advances in architectures and circuits, design methodologies and practical considerations - going from system-level specifications to silicon integration, packaging and measurements, with emphasis on nanometer CMOS implementation. The book emphasizes practical design issues - from high-level behavioural modelling i

  20. Adaptation of AASHTO Pavement Design Guide for Local Conditions

    Energy Technology Data Exchange (ETDEWEB)

    Hajek, J.J. [Applied Research Associates Inc., Toronto, ON (Canada)

    2001-07-01

    The methodology used to adapt the 1993 AASHTO Guide for Design of Pavement Structures to Ontario conditions was described. The guide expresses the effect of traffic loads on pavement performance using the concept of axle Load Equivalency Factors (LEF). LEF is regarded as a pavement damage factor assigned to each specific load and axle configuration. The size of LEF is related to the damage that is expected to occur from a standard load of 80 kN carried by a single axle with dual tires. The factors are summarized to yield the number of Equivalent Single Axle Loads (ESALs) a pavement is expected to sustain during its life. A summary was also provided of the additional work done to prepare for the transition to the proposed mechanistically-based 2002 AASHTO Guide. The paper focused only on the design of flexible pavements in terms of load characterization using equivalent single axle loads along with axle load spectra, below grade and material characterization, plus initial and terminal serviceability and reliability. The AASHTO Guide uses two parameters to deal with design reliability: design reliability level and overall standard deviation. Data collected on Ontario highway pavements and materials was used for assessing the design inputs. Other data was also collected from research and development studies, laboratory experiments, and from a survey of experienced pavement design engineers. The end result was a new grouping of Ontario soils for pavement design, recommended values for the resilient modulus of below grade soils, recommendations for structural layer coefficients for Ontario pavement materials and recommendations for the initial pavement serviceability based on Ontario smoothness specifications. Results of calibration and verification processes indicate that for new flexible pavements, the AASHTO-Ontario model is in good agreement with the observed results. It was recommended that the calibration and verification of the AASHTO-Ontario model should be a

  1. Architectural Refinement for the Design of Survivable Systems

    National Research Council Canada - National Science Library

    Ellison, Robert

    2001-01-01

    ...; that is, have no central administration and no unified security policy. The survivable architecture refinement is an iterative risk-driven process which adopts the structure of Boehm's Spiral Model Boehm 88...

  2. 2016 U.S. Department of Energy Race to Zero Student Design Competition Guide

    Energy Technology Data Exchange (ETDEWEB)

    2016-03-01

    This Guide to the Race to Zero Student Design Competition is a comprehensive overview of the framework, timeline, design parameters, judging criteria, and awards. This Guide provides links to resources that the teams will need.

  3. Standard guide for design criteria for plutonium gloveboxes

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2009-01-01

    1.1 This guide defines criteria for the design of glovebox systems to be used for the handling of plutonium in any chemical or physical form or isotopic composition or when mixed with other elements or compounds. Not included in the criteria are systems auxiliary to the glovebox systems such as utilities, ventilation, alarm, and waste disposal. Also not addressed are hot cells or open-face hoods. The scope of this guide excludes specific license requirements relating to provisions for criticality prevention, hazards control, safeguards, packaging, and material handling. Observance of this guide does not relieve the user of the obligation to conform to all federal, state, and local regulations for design and construction of glovebox systems. 1.2 The values stated in SI units are to be regarded as the standard. The values given in parentheses are for information only. 1.3 This standard does not purport to address all of the safety problems, if any, associated with its use. It is the responsibility of the user...

  4. Practical guide to organic field effect transistor circuit design

    CERN Document Server

    Sou, Antony

    2016-01-01

    The field of organic electronics spans a very wide range of disciplines from physics and chemistry to hardware and software engineering. This makes the field of organic circuit design a daunting prospect full of intimidating complexities, yet to be exploited to its true potential. Small focussed research groups also find it difficult to move beyond their usual boundaries and create systems-on-foil that are comparable with the established silicon world.This book has been written to address these issues, intended for two main audiences; firstly, physics or materials researchers who have thus far designed circuits using only basic drawing software; and secondly, experienced silicon CMOS VLSI design engineers who are already knowledgeable in the design of full custom transistor level circuits but are not familiar with organic devices or thin film transistor (TFT) devices.In guiding the reader through the disparate and broad subject matters, a concise text has been written covering the physics and chemistry of the...

  5. Alarm systems a guide to design, management and procurement

    CERN Document Server

    Engineering Equipment and Materials Users' Association. London

    2013-01-01

    Alarm systems form an essential part of the operator interfaces to large modern industrial facilities. They provide vital support to the operators by warning them of situations that need their attention and have an important role in preventing, controlling and mitigating the effects of abnormal situations. Since it was first published in 1999, EEMUA 191 has become the globally accepted and leading guide to good practice for all aspects of alarm systems. The guide, developed by users of alarm systems with input from the GB Health and Safety Executive, gives comprehensive guidance on designing, managing and procuring an effective alarm system. The new Third Edition has been comprehensively updated and includes guidance on implementing the alarm management philosophy in practice; applications in geographically distributed processes; and performance metrics and KPIs.

  6. Safety design guides for grouping and separation for CANDU 9

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Duk Su; Chang, Woo Hyun; Lee, Nam Young [Korea Atomic Energy Research Institute, Daeduk (Korea, Republic of); Wright, A C.D. [Atomic Energy of Canada Ltd., Toronto (Canada)

    1996-03-01

    This safety design guide for grouping and separation describes the philosophy of physical and functional separation for systems, structures and components in CANDU 9 plants and provides the requirements for the implementation of the philosophy in the detailed plant design. The separation of the safety systems is to ensure that common cause events and functional interconnections between systems do not impair the capability to perform the required safety functions for accident conditions. The separation requirements are also applied to the design by grouping the plant systems into two basic groups. Group 1 includes the power production systems and Group 2 includes the safety related systems required for the mitigation of serious process failure. The Group 2 is further separated into subgroups to ensure that events that could cause failure of a special safety system in one subgroup can be mitigated by the other subgroup. The change status for the regulatory requirements, code and standards should be traced and this safety design guide shall be updated accordingly. 2 tabs., 6 figs. (Author) .new.

  7. Safety design guides for grouping and separation for CANDU 9

    International Nuclear Information System (INIS)

    Lee, Duk Su; Chang, Woo Hyun; Lee, Nam Young; A. C. D. Wright

    1996-03-01

    This safety design guide for grouping and separation describes the philosophy of physical and functional separation for systems, structures and components in CANDU 9 plants and provides the requirements for the implementation of the philosophy in the detailed plant design. The separation of the safety systems is to ensure that common cause events and functional interconnections between systems do not impair the capability to perform the required safety functions for accident conditions. The separation requirements are also applied to the design by grouping the plant systems into two basic groups. Group 1 includes the power production systems and Group 2 includes the safety related systems required for the mitigation of serious process failure. The Group 2 is further separated into subgroups to ensure that events that could cause failure of a special safety system in one subgroup can be mitigated by the other subgroup. The change status for the regulatory requirements, code and standards should be traced and this safety design guide shall be updated accordingly. 2 tabs., 6 figs. (Author) .new

  8. Salt Repository Project shaft design guide: Revision 0

    International Nuclear Information System (INIS)

    1987-12-01

    The Salt Repository Project (SRP) Shaft Design Guide (SDG) and the accompanying SRP Input to Seismic Design define the basic approach for developing appropriate shaft designs for a high-level nuclear waste repository in salt at a proposed site in Deaf Smith County, Texas. The SDG is based on current mining industry standards and practices enhanced to meet the special needs of an underground nuclear waste repository. It provides a common approach for design of both the exploratory and repository shafts. The SDG defines shaft lining and material concepts and presents methods for calculating the loads and displacements that will be imposed on lining structures. It also presents the methodology and formulae for sizing lining components. The SDG directs the shaft designer to sources of geoscience and seismic design data for the Deaf Smith County, Texas repository site. In addition, the SDG describes methods for confirming shaft lining design by means of computer analysis, and it discusses performance monitoring needs that must be considered in the design. 113 refs., 18 figs., 14 tabs

  9. Guide-Plane Retention in Designing Removable Partial Dentures.

    Science.gov (United States)

    Mothopi-Peri, Matshediso; Owen, C Peter

    To compare the influence of abutment teeth guide planes and guiding surfaces on retention of a removable partial denture (RPD). Extracted teeth embedded into a maxillary cast in the first premolar and second molar positions simulated two bounded saddles. Acrylic resin RPDs were made with no guide planes, then with guide planes, then with guiding surfaces added to directly contact the guide planes. The maximum loads on removal from the cast were recorded. There was a significant increase in retention force of 1.6 times when only guide planes were present and of 10.2 times when guiding surfaces intimately contacted the guide planes. The retention of acrylic resin RPDs can be substantially increased by making their guiding surfaces intimately contact the guide planes of the teeth.

  10. Designing Environments for Handicapped Children: A Design Guide and Case Study. First Edition.

    Science.gov (United States)

    Moore, Gary T.; And Others

    This guide addresses the planning and architectural design of play/learning environments for special needs children. The exceptional children discussed include those with most types of mild to severe handicaps and developmental disabilities. Specifically excluded from consideration are health impairments, severe psycho-emotional difficulties such…

  11. Architectural Refinement for the Design of Survivable Systems

    National Research Council Canada - National Science Library

    Ellison, Robert

    2001-01-01

    This paper describes a process for systematically refining an enterprise system architecture to resist recognize and recover from deliberate, malicious attacks by applying reusable design primitives...

  12. Establishing appropriate inputs when using the mechanistic-empirical pavement design guide to design rigid pavements in Pennsylvania.

    Science.gov (United States)

    2011-03-01

    Each design input in the Mechanistic-Empirical Design Guide (MEPDG) required for the design of Jointed Plain Concrete : Pavements (JPCPs) is introduced and discussed in this report. Best values for Pennsylvania conditions were established and : recom...

  13. Safety design guide for safety related systems for CANDU 9

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Duk Su; Chang, Woo Hyun; Lee, Nam Young [Korea Atomic Energy Research Institute, Daeduk (Korea, Republic of); Wright, A.C.D. [Atomic Energy of Canada Ltd., Toronto (Canada)

    1996-03-01

    In general, two types of safety related systems and structures exist in the nuclear plant; The one is a systems and structures which perform safety functions during the normal operation of the plant, and the other is a systems and structures which perform safety functions to mitigate events caused by failure of the normally operating systems or by naturally occurring phenomena. In this safety design guide, these systems are identified in detail, and the major events for which the safety functions are required and the major safety requirements are identified in the list. As the probabilistic safety assessments are completed during the course of the project, additions or deletions to the list may be justified. 3 tabs. (Author) .new.

  14. Safety design guide for safety related systems for CANDU 9

    International Nuclear Information System (INIS)

    Lee, Duk Su; Chang, Woo Hyun; Lee, Nam Young; A. C. D. Wright

    1996-03-01

    In general, two types of safety related systems and structures exist in the nuclear plant; The one is a systems and structures which perform safety functions during the normal operation of the plant, and the other is a systems and structures which perform safety functions to mitigate events caused by failure of the normally operating systems or by naturally occurring phenomena. In this safety design guide, these systems are identified in detail, and the major events for which the safety functions are required and the major safety requirements are identified in the list. As the probabilistic safety assessments are completed during the course of the project, additions or deletions to the list may be justified. 3 tabs. (Author) .new

  15. Designing a monitoring program to estimate estuarine survival of anadromous salmon smolts: simulating the effect of sample design on inference

    Science.gov (United States)

    Romer, Jeremy D.; Gitelman, Alix I.; Clements, Shaun; Schreck, Carl B.

    2015-01-01

    A number of researchers have attempted to estimate salmonid smolt survival during outmigration through an estuary. However, it is currently unclear how the design of such studies influences the accuracy and precision of survival estimates. In this simulation study we consider four patterns of smolt survival probability in the estuary, and test the performance of several different sampling strategies for estimating estuarine survival assuming perfect detection. The four survival probability patterns each incorporate a systematic component (constant, linearly increasing, increasing and then decreasing, and two pulses) and a random component to reflect daily fluctuations in survival probability. Generally, spreading sampling effort (tagging) across the season resulted in more accurate estimates of survival. All sampling designs in this simulation tended to under-estimate the variation in the survival estimates because seasonal and daily variation in survival probability are not incorporated in the estimation procedure. This under-estimation results in poorer performance of estimates from larger samples. Thus, tagging more fish may not result in better estimates of survival if important components of variation are not accounted for. The results of our simulation incorporate survival probabilities and run distribution data from previous studies to help illustrate the tradeoffs among sampling strategies in terms of the number of tags needed and distribution of tagging effort. This information will assist researchers in developing improved monitoring programs and encourage discussion regarding issues that should be addressed prior to implementation of any telemetry-based monitoring plan. We believe implementation of an effective estuary survival monitoring program will strengthen the robustness of life cycle models used in recovery plans by providing missing data on where and how much mortality occurs in the riverine and estuarine portions of smolt migration. These data

  16. SPSS survival manual a step by step guide to data analysis using SPSS

    CERN Document Server

    Pallant, Julie

    2010-01-01

    In this thoroughly revised edition of her bestselling text, now covering up to version 18 of the SPSS software, Julie Pallant guides you through the entire research process, helping you choose the right data analysis technique for your project.

  17. Virtual Diagnostic Sensors Design for an Automated Guided Vehicle

    Directory of Open Access Journals (Sweden)

    Ralf Stetter

    2018-05-01

    Full Text Available In recent years, Automated Guided Vehicles (AGVs have been playing an increasingly important role in producing industry and infrastructure and will soon arrive to other areas of human life such as the transportation of goods and people. However, several challenges still aggravate the operation of AGVs, which limit the amount of implementation. One major challenge is the realization of reliable sensors that can capture the different aspects of the state of an AGV as well as its surroundings. One promising approach towards more reliable sensors is the supplementary application of virtual sensors, which are able to generate virtual measurements by using other sources of information such as actuator states and already existing sensors together with appropriate mathematical models. The focus of the research described in this paper is the design of virtual sensors determining forces and torques acting on an AGV. The proposed novel approach is using a quadratic boundedness approach, which makes it possible to include bounded disturbances acting on the AGV. One major advantage of the presented approach is that the use of complex tire models can be avoided. Information from acceleration and yaw rate sensors is processed in order to realize reliable virtual force and torque sensors. The resulting force and torque information can be used for several diagnostic purposes such as fault detection or fault prevention. The presented approach is explained and verified on the basis of an innovative design of an AGV. This innovative design addresses another major challenge for AGVs, which is the limited maneuvering possibilities of many AGV designs. The innovative design allows nearly unlimited maneuvering possibilities but requires reliable sensor data. The application of the approach in the AGV resulted in the insight that the generated estimates are consistent with the longitudinal forces and torques obtained by a proven reference model.

  18. A Kleptocrat's Survival Guide : Autocratic Longevity in the Face of Civil Conflict

    OpenAIRE

    Milante, Gary

    2007-01-01

    Autocratic regimes are quite often short-lived kleptocracies formed and maintained through force and used to appropriate wealth from subjects. Some of these autocracies collapse after only a year or two of plundering while others manage to survive for 15 or 20 years. This paper asks why some autocratic regimes survive while others fail. A database of political regimes from 1960 to 2003 is ...

  19. A haptic unit designed for magnetic-resonance-guided biopsy.

    Science.gov (United States)

    Tse, Z T H; Elhawary, H; Rea, M; Young, I; Davis, B L; Lamperth, M

    2009-02-01

    The magnetic fields present in the magnetic resonance (MR) environment impose severe constraints on any mechatronic device present in its midst, requiring alternative actuators, sensors, and materials to those conventionally used in traditional system engineering. In addition the spatial constraints of closed-bore scanners require a physical separation between the radiologist and the imaged region of the patient. This configuration produces a loss of the sense of touch from the target anatomy for the clinician, which often provides useful information. To recover the force feedback from the tissue, an MR-compatible haptic unit, designed to be integrated with a five-degrees-of-freedom mechatronic system for MR-guided prostate biopsy, has been developed which incorporates position control and force feedback to the operator. The haptic unit is designed to be located inside the scanner isocentre with the master console in the control room. MR compatibility of the device has been demonstrated, showing a negligible degradation of the signal-to-noise ratio and virtually no geometric distortion. By combining information from the position encoder and force sensor, tissue stiffness measurement along the needle trajectory is demonstrated in a lamb liver to aid diagnosis of suspected cancerous tissue.

  20. Textile Design: A Suggested Program Guide. Fashion Industry Series No. 3.

    Science.gov (United States)

    Fashion Inst. of Tech., New York, NY.

    The textile design guide is the third of a series of five interrelated program resource guides encompassing the various dimensions of the fashion industry. The job-preparatory guide is conceived to provide youth and adults with intensive preparation for initial entry employment and also with career advancement opportunities within specific…

  1. Advanced Energy Design Guide K-12: Next Generation of School Design and Operation

    Energy Technology Data Exchange (ETDEWEB)

    Torcellini, Paul A [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Pless, Shanti [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2018-01-01

    Driven by energy efficiency advances and renewable energy cost reductions, zero energy buildings are popping up all around the country. Although zero energy represents a bold paradigm shift - from buildings that consume energy to buildings that produce enough energy to meet their energy needs on an annual basis - it isn't a sudden shift. Zero energy buildings are the result of steady, incremental progress by researchers and building professionals working together to improve building energy performance. ASHRAE is taking the lead by publishing - in partnership with the American Institute of Architects (AIA), the Illuminating Engineering Society (IES), the U.S. Green Building Council (USGBC), and the U.S. Department of Energy (DOE) - a new series of advanced energy design guides (AEDGs) focused on zero energy buildings. The recently completed Advanced Energy Design Guide for K-12 School Buildings: Achieving Zero Energy (K-12 ZE AEDG) is the first in this series.

  2. Constraining designs for synthesis and timing analysis a practical guide to synopsys design constraints (SDC)

    CERN Document Server

    Gangadharan, Sridhar

    2013-01-01

    This book serves as a hands-on guide to timing constraints in integrated circuit design.  Readers will learn to maximize performance of their IC designs, by specifying timing requirements correctly.  Coverage includes key aspects of the design flow impacted by timing constraints, including synthesis, static timing analysis and placement and routing.  Concepts needed for specifying timing requirements are explained in detail and then applied to specific stages in the design flow, all within the context of Synopsys Design Constraints (SDC), the industry-leading format for specifying constraints.  ·         Provides a hands-on guide to synthesis and timing analysis, using Synopsys Design Constraints (SDC), the industry-leading format for specifying constraints; ·         Includes key topics of interest to a synthesis, static timing analysis or  place and route engineer; ·         Explains which constraints command to use for ease of maintenance and reuse, given several options pos...

  3. Design of the Mechanical Parts for the Neutron Guide System at HANARO

    International Nuclear Information System (INIS)

    Shin, J. W.; Cho, Y. G.; Cho, S. J.; Ryu, J. S.

    2008-01-01

    The research reactor HANARO (High-flux Advanced Neutron Application ReactOr) in Korea will be equipped with a neutron guide system, in order to transport cold neutrons from the neutron source to the neutron scattering instruments in the neutron guide hall near the reactor building. The neutron guide system of HANARO consists of the in-pile plug assembly with in-pile guides, the primary shutter with in-shutter guides, the neutron guides in the guide shielding room with dedicated secondary shutters, and the neutron guides connected to the instruments in the neutron guide hall. Functions of the in-pile plug assembly are to shield the reactor environment from nuclear radiation and to support the neutron guides and maintain them precisely oriented. The primary shutter is a mechanical structure to be installed just after the in-pile plug assembly, which stops neutron flux on demand. This paper describes the design of the in-pile assembly and the primary shutter for the neutron guide system at HANARO. The design of the guide shielding assembly for the primary shutter and the neutron guides is also presented

  4. End-Tidal CO2-Guided Chest Compression Delivery Improves Survival in a Neonatal Asphyxial Cardiac Arrest Model.

    Science.gov (United States)

    Hamrick, Justin T; Hamrick, Jennifer L; Bhalala, Utpal; Armstrong, Jillian S; Lee, Jeong-Hoo; Kulikowicz, Ewa; Lee, Jennifer K; Kudchadkar, Sapna R; Koehler, Raymond C; Hunt, Elizabeth A; Shaffner, Donald H

    2017-11-01

    To determine whether end-tidal CO2-guided chest compression delivery improves survival over standard cardiopulmonary resuscitation after prolonged asphyxial arrest. Preclinical randomized controlled study. University animal research laboratory. 1-2-week-old swine. After undergoing a 20-minute asphyxial arrest, animals received either standard or end-tidal CO2-guided cardiopulmonary resuscitation. In the standard group, chest compression delivery was optimized by video and verbal feedback to maintain the rate, depth, and release within published guidelines. In the end-tidal CO2-guided group, chest compression rate and depth were adjusted to obtain a maximal end-tidal CO2 level without other feedback. Cardiopulmonary resuscitation included 10 minutes of basic life support followed by advanced life support for 10 minutes or until return of spontaneous circulation. Mean end-tidal CO2 at 10 minutes of cardiopulmonary resuscitation was 34 ± 8 torr in the end-tidal CO2 group (n = 14) and 19 ± 9 torr in the standard group (n = 14; p = 0.0001). The return of spontaneous circulation rate was 7 of 14 (50%) in the end-tidal CO2 group and 2 of 14 (14%) in the standard group (p = 0.04). The chest compression rate averaged 143 ± 10/min in the end-tidal CO2 group and 102 ± 2/min in the standard group (p tidal CO2-guided chest compression delivery. The response of the relaxation arterial pressure and cerebral perfusion pressure to the initial epinephrine administration was greater in the end-tidal CO2 group than in the standard group (p = 0.01 and p = 0.03, respectively). The prevalence of resuscitation-related injuries was similar between groups. End-tidal CO2-guided chest compression delivery is an effective resuscitation method that improves early survival after prolonged asphyxial arrest in this neonatal piglet model. Optimizing end-tidal CO2 levels during cardiopulmonary resuscitation required that chest compression delivery rate exceed current guidelines

  5. Rationale and design of the GUIDE-IT study: Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure.

    Science.gov (United States)

    Felker, G Michael; Ahmad, Tariq; Anstrom, Kevin J; Adams, Kirkwood F; Cooper, Lawton S; Ezekowitz, Justin A; Fiuzat, Mona; Houston-Miller, Nancy; Januzzi, James L; Leifer, Eric S; Mark, Daniel B; Desvigne-Nickens, Patrice; Paynter, Gayle; Piña, Ileana L; Whellan, David J; O'Connor, Christopher M

    2014-10-01

    The GUIDE-IT (Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure) study is designed to determine the safety, efficacy, and cost-effectiveness of a strategy of adjusting therapy with the goal of achieving and maintaining a target N-terminal pro-B-type natriuretic peptide (NT-proBNP) level of levels provide key prognostic information in patients with HF. Therapies proven to improve outcomes in patients with HF are generally associated with decreasing levels of NPs, and observational data show that decreases in NP levels over time are associated with favorable outcomes. Results from smaller prospective, randomized studies of this strategy thus far have been mixed, and current guidelines do not recommend serial measurement of NP levels to guide therapy in patients with HF. GUIDE-IT is a prospective, randomized, controlled, unblinded, multicenter clinical trial designed to randomize approximately 1,100 high-risk subjects with systolic HF (left ventricular ejection fraction ≤40%) to either usual care (optimized guideline-recommended therapy) or a strategy of adjusting therapy with the goal of achieving and maintaining a target NT-proBNP level of study are followed up at regular intervals and after treatment adjustments for a minimum of 12 months. The primary endpoint of the study is time to cardiovascular death or first hospitalization for HF. Secondary endpoints include time to cardiovascular death and all-cause mortality, cumulative mortality, health-related quality of life, resource use, cost-effectiveness, and safety. The GUIDE-IT study is designed to definitively assess the effects of an NP-guided strategy in high-risk patients with systolic HF on clinically relevant endpoints of mortality, hospitalization, quality of life, and medical resource use. (Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure [GUIDE-IT]; NCT01685840). Copyright © 2014 American College of Cardiology Foundation

  6. Designing new guides and instruments using McStas

    DEFF Research Database (Denmark)

    Farhi, E.; Hansen, T.; Wildes, A.

    2002-01-01

    of guides, neutron optics and instruments [1]. To date, the McStas package has been extensively used at the Institut Laue-Langevin, Grenoble, France, for various studies including cold and thermal guides with ballistic geometry, diffractometers, triple-axis, backscattering and time-of-flight spectrometers...

  7. Guiding Design: Exposing Librarian and Student Mental Models of Research Guides

    Science.gov (United States)

    Sinkinson, Caroline; Alexander, Stephanie; Hicks, Alison; Kahn, Meredith

    2012-01-01

    This article details an open card sort study administered to undergraduate students, graduate students, and librarians at the University of Colorado at Boulder in order to reveal perceptions of library research guides. The study identifies user group preferences for organization and content of research guides, as well as themes emerging from the…

  8. A Review Of Design And Control Of Automated Guided Vehicle Systems

    OpenAIRE

    Le-Anh, Tuan; Koster, René

    2004-01-01

    textabstractThis paper presents a review on design and control of automated guided vehicle systems. We address most key related issues including guide-path design, estimating the number of vehicles, vehicle scheduling, idle-vehicle positioning, battery management, vehicle routing, and conflict resolution. We discuss and classify important models and results from key publications in literature on automated guided vehicle systems, including often-neglected areas, such as idle-vehicle positionin...

  9. Regulatory compliance guide for DOT-7A type A packaging design

    International Nuclear Information System (INIS)

    Kelly, D.L.

    1996-01-01

    The purpose of this guide is to provide instruction for assuring that the regulatory design requirements for a DOT-7A Type A packaging are met. This guide also supports the testing and evaluation activities that are performed on new packaging designs by a DOE-approved test facility through the DOE's DOT-7A Test Program. This Guide was updated to incorporate regulatory changes implemented by HM-169A (49 CFR, 'Transportation')

  10. A PhD is not enough! a guide to survival in science

    CERN Document Server

    Feibelman, Peter J

    2011-01-01

    A Ph. D. Is Not Enough! is required reading for anyone thinking of applying to graduate school or entering the science job market. Focusing on critical survival skills, it offers sound advice on selecting a thesis or postdoctoral adviser; choosing among research jobs in academia, government laboratories, and industry; and defining a research program. This new edition features updates throughout and a new chapter reflecting todays rapidly changing world.

  11. Apparel Design and Production: A Suggested Program Guide. Fashion Industry Series No. 2.

    Science.gov (United States)

    Fashion Inst. of Tech., New York, NY.

    The apparel design and production guide is the second of a series of five interrelated program resource guides encompassing the various dimensions of the fashion industry. Designed to provide youths and adults with intensive preparation for initial entry employment and also with career advancement opportunities within specific categories of jobs,…

  12. A Review Of Design And Control Of Automated Guided Vehicle Systems

    NARCIS (Netherlands)

    T. Le-Anh (Tuan); M.B.M. de Koster (René)

    2004-01-01

    textabstractThis paper presents a review on design and control of automated guided vehicle systems. We address most key related issues including guide-path design, estimating the number of vehicles, vehicle scheduling, idle-vehicle positioning, battery management, vehicle routing, and conflict

  13. CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries.

    Science.gov (United States)

    Heigwer, Florian; Zhan, Tianzuo; Breinig, Marco; Winter, Jan; Brügemann, Dirk; Leible, Svenja; Boutros, Michael

    2016-03-24

    Genetic screens using CRISPR/Cas9 are a powerful method for the functional analysis of genomes. Here we describe CRISPR library designer (CLD), an integrated bioinformatics application for the design of custom single guide RNA (sgRNA) libraries for all organisms with annotated genomes. CLD is suitable for the design of libraries using modified CRISPR enzymes and targeting non-coding regions. To demonstrate its utility, we perform a pooled screen for modulators of the TNF-related apoptosis inducing ligand (TRAIL) pathway using a custom library of 12,471 sgRNAs. CLD predicts a high fraction of functional sgRNAs and is publicly available at https://github.com/boutroslab/cld.

  14. Multi-objective optimisation for spacecraft design for demise and survivability

    OpenAIRE

    Trisolini, Mirko; Colombo, Camilla; Lewis, Hugh

    2017-01-01

    The paper presents the development of a multi-objective optimisation framework to study the effects that preliminary design choices have on the demisability and the survivability of a spacecraft. Building a spacecraft such that most of it will demise during the re-entry through design-for-demise strategies may lead to design that are more vulnerable to space debris impacts, thus compromising the reliability of the mission. The two models developed to analyse the demisability and the survivabi...

  15. Longevity of anterior resin-bonded bridges: survival rates of two tooth preparation designs.

    Science.gov (United States)

    Abuzar, M; Locke, J; Burt, G; Clausen, G; Escobar, K

    2018-04-16

    Significant developments have occurred in the design of resin-bonded bridges (RBB) over the past two decades. They are commonly used as an alternative treatment option for a single missing tooth. The longevity of these bridges needs to be further investigated to evaluate long-term outcomes for this option to remain relevant. A cohort of patients who received anterior resin-bonded bridges (ARBB) over two decades was studied retrospectively. Longevity of 206 ARBB was assessed using Kaplan-Meier probability estimates. The two modified tooth preparation designs investigated were: (A) mesial and distal vertical grooves only; and (B) one proximal groove adjacent to the pontic and two palatal grooves. Age and gender of the patient cohort were also recorded. Overall survival rate of ARBB was 98% at 5 years, 97.2% at 10 years, and 95.1% from 12 years till 21 years. Survival curves showed minor differences when compared for the two designs, age groups and gender of ARBB recipients. Differences in the proportion of surviving bridges for design A (95.96%) and design B (98.13%) were not statistically significant (Fisher's exact test). Anterior RBB with described tooth preparation designs demonstrate a high survival rate. © 2018 Australian Dental Association.

  16. In vitro chemo-sensitivity assay guided chemotherapy is associated with prolonged overall survival in cancer patients.

    Science.gov (United States)

    Udelnow, Andrej; Schönfęlder, Manfred; Würl, Peter; Halloul, Zuhir; Meyer, Frank; Lippert, Hans; Mroczkowski, Paweł

    2013-06-01

    The overall survival (OS) of patients suffering From various tumour entities was correlated with the results of in vitro-chemosensitivity assay (CSA) of the in vivo applied drugs. Tumour specimen (n=611) were dissected in 514 patients and incubated for primary tumour cell culture. The histocytological regression assay was performed 5 days after adding chemotherapeutic substances to the cell cultures. n=329 patients undergoing chemotherapy were included in the in vitro/in vivo associations. OS was assessed and in vitro response groups compared using survival analysis. Furthermore Cox-regression analysis was performed on OS including CSA, age, TNM classification and treatment course. The growth rate of the primary was 73-96% depending on tumour entity. The in-vitro response rate varied with histology and drugs (e.g. 8-18% for methotrexate and 33-83% for epirubicine). OS was significantly prolonged for patients treated with in vitro effective drugs compared to empiric therapy (log-rank-test, p=0.0435). Cox-regression revealed that application of in vitro effective drugs, residual tumour and postoperative radiotherapy determined the death risk independently. When patients were treated with drugs effective in our CSA, OS was significantly prolonged compared to empiric therapy. CSA guided chemotherapy should be compared to empiric treatment by a prospective randomized trial.

  17. Designing new guides and instruments using McStas

    CERN Document Server

    Farhi, E; Wildes, A R; Ghosh, R; Lefmann, K

    2002-01-01

    With the increasing complexity of modern neutron-scattering instruments, the need for powerful tools to optimize their geometry and physical performances (flux, resolution, divergence, etc.) has become essential. As the usual analytical methods reach their limit of validity in the description of fine effects, the use of Monte Carlo simulations, which can handle these latter, has become widespread. The McStas program was developed at Riso National Laboratory in order to provide neutron scattering instrument scientists with an efficient and flexible tool for building Monte Carlo simulations of guides, neutron optics and instruments. To date, the McStas package has been extensively used at the Institut Laue-Langevin, Grenoble, France, for various studies including cold and thermal guides with ballistic geometry, diffractometers, triple-axis, backscattering and time-of-flight spectrometers. In this paper, we present some simulation results concerning different guide geometries that may be used in the future at th...

  18. Guide to the safety design examination about light water reactor facilities for power generation

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    This guide was compiled to evaluate the validity of the design policy when the safety design is examined at the time of the application for approval of the installation of nuclear reactors. About 7 years has elapsed since the existing guide was established, and the more appropriate guide to evaluate the safety should be made on the basis of the knowledge and experience accumulated thereafter. The range of application of this guide is limited to the above described evaluation, and it is not intended as the general standard for the design of nuclear reactors. First, the definition of the words used in this guide is given. Then, the guide to the safety examination is described about the general matters of reactor facilities, nuclear reactors and the measuring and controlling system, reactor-stopping system, reactivity-controlling system and safety protection system, reactor-cooling system, reactor containment vessels, fuel handling and waste treatment system. Several matters which require attention in the application of this guide or the clarification of the significance and interpretation of the guide itself were found, therefore the explanation about them was added at the end of this guide. (Kako, I.)

  19. Design procedures for heat-straightening repair : an engineering guide.

    Science.gov (United States)

    1992-12-01

    This report summarizes over four years of research on heat-straightening repairs and provides a prototype engineering guide for the application of heat-straightening to bridge structures. It is based on the research results detailed in a companion re...

  20. Service design based on ITIL V3 a management guide

    CERN Document Server

    Bon, Jan van; Kolthof, Axel

    2010-01-01

    This Management Guide is a concise summary of the IT Service Management ? An Introduction. A quick, portable reference tool to the standards used within the Service Management community.What are the key service management processes? What is the ?lifecycle? approach?What are the elements of ISO20000? All this and descriptions of other popular frameworks are covered.

  1. Interaction of impeller and guide vane in a series-designed axial-flow pump

    International Nuclear Information System (INIS)

    Kim, S; Choi, Y S; Lee, K Y; Kim, J H

    2012-01-01

    In this paper, the interaction of the impeller and guide vane in a series-designed axial-flow pump was examined through the implementation of a commercial CFD code. The impeller series design refers to the general design procedure of the base impeller shape which must satisfy the various flow rate and head requirements by changing the impeller setting angle and number of blades of the base impeller. An arc type meridional shape was used to keep the meridional shape of the hub and shroud with various impeller setting angles. The blade angle and the thickness distribution of the impeller were designed as an NACA airfoil type. In the design of the guide vane, it was necessary to consider the outlet flow condition of the impeller with the given setting angle. The meridional shape of the guide vane were designed taking into consideration the setting angle of the impeller, and the blade angle distribution of the guide vane was determined with a traditional design method using vane plane development. In order to achieve the optimum impeller design and guide vane, three-dimensional computational fluid dynamics and the DOE method were applied. The interaction between the impeller and guide vane with different combination set of impeller setting angles and number of impeller blades was addressed by analyzing the flow field of the computational results.

  2. Unified Facilities Criteria (UFC) Design Guide. Army Reserve Facilities

    Science.gov (United States)

    2010-02-01

    horticulturally appropriate to the site specific location in which they are planted. Consideration should be given to adjacent structures and improvements...impact FPI Federal Prison Industries FPM Feet per minute GFCI Government-furnished/contractor-installed or Ground-Fault Circuit Interrupter GFGI...Uniform Federal Accessibility Standards UFGs Unified Facility Guide Specifications UFGs Rst UFGS - Reserve Support Team UnICoR Federal Prison Industry

  3. Interface Heuristics and Style Guide Design: An Air Battle Management Case Study

    National Research Council Canada - National Science Library

    Nelson, W. T; Bolia, Robert S

    2005-01-01

    This paper describes the development of a human-machine interface style guide designed to promote a common look and feel among operator interfaces employed by air battle managers in the United States...

  4. Guide design study for the high-resolution backscattering spectrometer FIRES

    Energy Technology Data Exchange (ETDEWEB)

    Pelley, C; Kargl, F; Sakai, V Garcia; Telling, M T F; Fernandez-Alonso, F; Demmel, F, E-mail: franz.demmel@stfc.ac.uk

    2010-11-01

    Different options are considered to transport cold neutrons along 90 m for the proposed new spectrometer FIRES at the ISIS facility. Monte Carlo simulations using the McStas programme package are used to assess the performance of various guide designs from the biological shield to the sample position. By employing a curved geometry, to avoid the direct line of sight, a hybrid design which combines a curved ballistic guide and an elliptic focusing section appears to be the best solution.

  5. Design guide for heat transfer equipment in water-cooled nuclear reactor systems

    International Nuclear Information System (INIS)

    1975-07-01

    Information pertaining to design methods, material selection, fabrication, quality assurance, and performance tests for heat transfer equipment in water-cooled nuclear reactor systems is given in this design guide. This information is intended to assist those concerned with the design, specification, and evaluation of heat transfer equipment for nuclear service and the systems in which this equipment is required. (U.S.)

  6. Reliable design of electronic equipment an engineering guide

    CERN Document Server

    Natarajan, Dhanasekharan

    2014-01-01

    This book explains reliability techniques with examples from electronics design for the benefit of engineers. It presents the application of de-rating, FMEA, overstress analyses and reliability improvement tests for designing reliable electronic equipment. Adequate information is provided for designing computerized reliability database system to support the application of the techniques by designers. Pedantic terms and the associated mathematics of reliability engineering discipline are excluded for the benefit of comprehensiveness and practical applications. This book offers excellent support

  7. A practical guide to designing a poster for presentation.

    Science.gov (United States)

    Briggs, D J

    Poster presentations are frequently used to disseminate research findings and clinical initiatives at conferences, and present module material for educational courses. However, many nurses lack confidence when it comes to designing posters. This article considers the skills required to design a poster. Aspects of good poster design are also discussed.

  8. A Facilities Manager's Guide to Green Building Design.

    Science.gov (United States)

    Simpson, Walter

    2001-01-01

    Explains how the "green building" approach to educational facilities design creates healthy, naturally lit, attractive buildings with lower operating and life cycle costs. Tips on getting started on a green design and overcoming the barriers to the green design concept are discussed. (GR)

  9. Vaadin 7 UI design by example beginner's guide

    CERN Document Server

    Duarte, Alejandro

    2013-01-01

    This book is a hands-on Beginner's Guide for developers who are new to Vaadin and/or Vaadin UI components. The book will teach readers through examples to use each of the exciting components to build and add various aspects of the user interface to their web apps.If you have experience with the Java language and want to create web applications that look good without having to deal with HTML, XML, and JavaScript, this book is for you. Basic Java programming skills are required, but no web development knowledge is needed at all.

  10. Swipe this! the guide to great touchscreen game design

    CERN Document Server

    Rogers, Scott

    2012-01-01

    Learn to design games for tablets from a renowned game designer! Eager to start designing games for tablets but not sure where to start? Look no further! Gaming guru Scott Rogers has his finger on the pulse of tablet game design and is willing to impart his wisdom and secrets for designing exciting and successful games. As the creator of such venerable games as God of War, the SpongeBob Squarepants series, and Pac-Man World, to name a few, Rogers writes from personal experience and in this unique book, he hands you the tools to create your own tablet games for the iPad, Android tablets, Ninten

  11. Designing an ultrafast laser virtual laboratory using MATLAB GUIDE

    International Nuclear Information System (INIS)

    Cambronero-López, F; Gómez-Varela, A I; Bao-Varela, C

    2017-01-01

    In this work we present a virtual simulator developed using the MATLAB GUIDE environment based on the numerical resolution of the nonlinear Schrödinger equation (NLS) and using the split step method for the study of the spatial–temporal propagation of nonlinear ultrashort laser pulses. This allows us to study the spatial–temporal propagation of ultrafast pulses as well as the influence of high-order spectral phases such as group delay dispersion and third-order dispersion on pulse compression in time. The NLS can describe several nonlinear effects, in particular in this paper we consider the Kerr effect, cross-polarized wave generation and cubic–quintic propagation in order to highlight the potential of this equation combined with the GUIDE environment. Graphical user interfaces are commonly used in science and engineering teaching due to their educational value, and have proven to be an effective way to engage and motivate students. Specifically, the interactive graphical interfaces presented provide the visualization of some of the most important nonlinear optics phenomena and allows users to vary the values of the main parameters involved. (paper)

  12. Designing an ultrafast laser virtual laboratory using MATLAB GUIDE

    Science.gov (United States)

    Cambronero-López, F.; Gómez-Varela, A. I.; Bao-Varela, C.

    2017-05-01

    In this work we present a virtual simulator developed using the MATLAB GUIDE environment based on the numerical resolution of the nonlinear Schrödinger equation (NLS) and using the split step method for the study of the spatial-temporal propagation of nonlinear ultrashort laser pulses. This allows us to study the spatial-temporal propagation of ultrafast pulses as well as the influence of high-order spectral phases such as group delay dispersion and third-order dispersion on pulse compression in time. The NLS can describe several nonlinear effects, in particular in this paper we consider the Kerr effect, cross-polarized wave generation and cubic-quintic propagation in order to highlight the potential of this equation combined with the GUIDE environment. Graphical user interfaces are commonly used in science and engineering teaching due to their educational value, and have proven to be an effective way to engage and motivate students. Specifically, the interactive graphical interfaces presented provide the visualization of some of the most important nonlinear optics phenomena and allows users to vary the values of the main parameters involved.

  13. Design guide for category II reactors light and heavy water cooled reactors

    International Nuclear Information System (INIS)

    Brynda, W.J.; Lobner, P.R.; Powell, R.W.; Straker, E.A.

    1978-05-01

    The Department of Energy (DOE), in the ERDA Manual, requires that all DOE-owned reactors be sited, designed, constructed, modified, operated, maintained, and decommissioned in a manner that gives adequate consideration to health and safety factors. Specific guidance pertinent to the safety of DOE-owned reactors is found in Chapter 0540 of the ERDA Manual. The purpose of this Design Guide is to provide additional guidance to aid the DOE facility contractor in meeting the requirement that the siting, design, construction, modification operation, maintainance, and decommissioning of DOW-owned reactors be in accordance with generally uniform standards, guide and codes which are comparable to those applied to similar reactors licensed by the Nuclear Regulatory Commission (NRC). This Design Guide deals principally with the design and functional requirements of Category II reactor structure, components, and systems

  14. Design of intermediate die shape of multistage profile drawing for linear motion guide

    International Nuclear Information System (INIS)

    Lee, Sang Kon; Lee, Jae Eun; Kim, Sung Min; Kim, Byung Min

    2010-01-01

    The design of an intermediate die shape is very important in multistage profile drawing. In this study, two design methods for the intermediate die shape of a multistage profile drawing for producing a linear motion guide (LM) guide is proposed. One is the electric field analysis method using the equipotential lines generated by electric field analysis, and the other is the virtual die method using a virtual drawing die constructed from the initial material and the final product shape. In order to design the intermediate die shapes of a multistage profile drawing for producing LM guide, the proposed design methods are applied, and then FE analysis and profile drawing experiment are performed. As a result, based on the measurement of dimensional accuracy, it can be known that the intermediate die shape can be designed effectively

  15. Design guide for fire protection of grouped electrical cables

    International Nuclear Information System (INIS)

    Dungan, K.W.

    1991-05-01

    This paper develops design guidance for fire protection of grouped electrical cables using previous research and the concept of design objectives based on damage limits. A quantitative approach is taken to establishing performance-oriented design objectives and addressing fires exposing cables as well as cable fires. A one-page Design Calculation Checklist is developed and examples are shown. In addition, testing was done for placement of linear thermal detection on cable trays and recommendations are given. 32 refs., 10 figs., 8 tabs

  16. A novel double fine guide sensor design on space telescope

    Science.gov (United States)

    Zhang, Xu-xu; Yin, Da-yi

    2018-02-01

    To get high precision attitude for space telescope, a double marginal FOV (field of view) FGS (Fine Guide Sensor) is proposed. It is composed of two large area APS CMOS sensors and both share the same lens in main light of sight. More star vectors can be get by two FGS and be used for high precision attitude determination. To improve star identification speed, the vector cross product in inter-star angles for small marginal FOV different from traditional way is elaborated and parallel processing method is applied to pyramid algorithm. The star vectors from two sensors are then used to attitude fusion with traditional QUEST algorithm. The simulation results show that the system can get high accuracy three axis attitudes and the scheme is feasibility.

  17. Resisting Technological Gravity: Using Guiding Principles for Instructional Design

    Science.gov (United States)

    McDonald, Jason K.

    2010-01-01

    Instructional designers face tremendous pressure to abandon the essential characteristics of educational approaches, and settle instead for routine practices that do not preserve the level of quality those approaches originally expressed. Because this pressure can be strong enough to affect designers almost as gravity affects objects in the…

  18. Level up! the guide to great video game design

    CERN Document Server

    Rogers, Scott

    2014-01-01

    Want to design your own video games? Let expert Scott Rogers show you how! If you want to design and build cutting-edge video games but aren't sure where to start, then the SECOND EDITION of the acclaimed Level Up! is for you! Written by leading video game expert Scott Rogers, who has designed the hits Pac Man World, Maximo and SpongeBob Squarepants, this updated edition provides clear and well-thought out examples that forgo theoretical gobbledygook with charmingly illustrated concepts and solutions based on years of professional experience. Level Up! 2nd Edition has been NEWLY EXPANDED to

  19. Improved design of guide wall of bank spillway at Yutang Hydropower Station

    Directory of Open Access Journals (Sweden)

    Ji-bao Wang

    2010-03-01

    Full Text Available Ensuring that water flows smoothly into spillways is the main challenge in spillway design. In order to help avoid the formation of vortices and separation of flow along the guide wall in front of the gates during overflow through the spillway, an experiment with a physical model of the Yutang Dam bank spillway was carried out. The profile of the guide wall was redesigned to eliminate the formation of vortices and separation of flow. This involves opening up holes in the middle part of the guide wall. The test results show that the design is effective in improving the flow conditions of the inlet, and in ensuring the desired values of water head along the guide wall and discharge capacities of the spillway.

  20. Principles of VLSI RTL design a practical guide

    CERN Document Server

    Churiwala, Sanjay; Gianfagna, Mike

    2011-01-01

    This book examines the impact of register transfer level (RTL) design choices that may result in issues of testability, data synchronization across clock domains, synthesizability, power consumption and routability, that appear later in the product lifecycle.

  1. Guided exploration of physically valid shapes for furniture design

    KAUST Repository

    Umetani, Nobuyuki; Igarashi, Takeo; Mitra, Niloy J.

    2012-01-01

    Geometric modeling and the physical validity of shapes are traditionally considered independently. This makes creating aesthetically pleasing yet physically valid models challenging. We propose an interactive design framework for efficient

  2. Integral Engine Inlet Particle Separator. Volume 2. Design Guide

    Science.gov (United States)

    1975-08-01

    herein will be used in the design of integral inlet particle separators for future Army aircraft gas turbine engines. Apprupriate technical personnel...into the comprensor at some future date. 5. A typical scavenge vane design Js; shown in Figures 85 and 86. The important features of the scavenge...service passageweys, for cooling of oil, and for directing sand and air into the scroll. Orientetion of the vanes is set by collection efficiency

  3. The NUSS safety guides in design and the use of computers

    International Nuclear Information System (INIS)

    Fischer, J.

    1986-01-01

    After a brief summary of the NUSS programme, the two design guides are discussed which deal with instrumentation and control circuitry. The potential use of computers is covered differently in these guides because of the historical development and more importantly because of the difference in importance to safety of the I and C systems which are dealt with in these papers. The Agency would consider modifications to the existing guides only when sufficient consensus about the use of computers would warrant a revision of the documents. (author)

  4. Virtual design of the neutron guide for the TOF spectrometer NEAT

    International Nuclear Information System (INIS)

    Izaola, Zunbeltz; Russina, Margarita

    2010-01-01

    We present the results of a virtual design study based on Monte-Carlo neutron ray tracing techniques for the neutron guide of the time of flight (TOF) spectrometer NEAT. We studied several configurations with linearly or elliptically tapered compressors with different degrees of focusing and different guide coatings. The calculations were performed and crosschecked using two software packages which produced similar results. The geometrical arrangement of selected guide components was optimised with the Particle Swarm Optimisation algorithm. The results of the Monte Carlo simulations confirm an expected intensity gain factor of approximately 5, that can be achieved by the optimal configuration.

  5. Virtual design of the neutron guide for the TOF spectrometer NEAT

    Science.gov (United States)

    Izaola, Zunbeltz; Russina, Margarita

    2010-11-01

    We present the results of a virtual design study based on Monte-Carlo neutron ray tracing techniques for the neutron guide of the time of flight (TOF) spectrometer NEAT. We studied several configurations with linearly or elliptically tapered compressors with different degrees of focusing and different guide coatings. The calculations were performed and crosschecked using two software packages which produced similar results. The geometrical arrangement of selected guide components was optimised with the Particle Swarm Optimisation algorithm. The results of the Monte Carlo simulations confirm an expected intensity gain factor of approximately 5, that can be achieved by the optimal configuration.

  6. Radiation effects on electronic equipment: a designers'/users' guide for the nuclear power industry

    International Nuclear Information System (INIS)

    Sharp, R.E.; Garlick, D.R.

    1994-01-01

    The Designers'/Users' Guide to the effects of radiation on electronics is published by the Radiation Testing Service of AEA Technology. The aim of the Guide is to document the available information that we have generated and collected over some ten years whilst operating as a radiation effects and design consultancy to the nuclear power industry. We hope that this will enable workers within the industry better to understand the likely effects of radiation on the system or plant being designed and so minimise the problems that can arise. (Author)

  7. Change Agent Survival Guide

    Science.gov (United States)

    Dunbar, Folwell L.

    2011-01-01

    Consulting is a rough racket. Only a tarantula hair above IRS agents, meter maids and used car sales people, the profession is a prickly burr for slings and arrows. Throw in education, focus on dysfunctional schools and call oneself a "change agent," and this bad rap all but disappears. Unfortunately, though, consulting/coaching/mentoring in…

  8. Copyright: A Survival Guide

    OpenAIRE

    Hughes, Katie

    2017-01-01

    Presentation for HASS PhD students given on 24th October 2017. The presentation provides an overview about copyright, Fair Dealing, and how to seek permission for Third Party copyrighted material. The presentation does not include legal advice.

  9. Guide to the design, testing and use of packaging for the safe transport of radioactive materials

    International Nuclear Information System (INIS)

    1976-01-01

    This guide gives to designers, manufacturers and users of packaging, advice supplementary to, or in amplification of, the recommendations made by the International Atomic Energy Agency for the safe transport of radioactive materials as given in IAEA Safety Series No. 6 (1973) and the advisory material given in IAEA Safety Series No. 37 (1973). This guide should be read and used in conjunction with these recommendations, the appropriate national regulations and any applicable regulations or requirements of the carriers concerned. (author)

  10. Methodology of Computer-Aided Design of Variable Guide Vanes of Aircraft Engines

    Science.gov (United States)

    Falaleev, Sergei V.; Melentjev, Vladimir S.; Gvozdev, Alexander S.

    2016-01-01

    The paper presents a methodology which helps to avoid a great amount of costly experimental research. This methodology includes thermo-gas dynamic design of an engine and its mounts, the profiling of compressor flow path and cascade design of guide vanes. Employing a method elaborated by Howell, we provide a theoretical solution to the task of…

  11. Designing the stem cell microenvironment for guided connective tissue regeneration.

    Science.gov (United States)

    Bogdanowicz, Danielle R; Lu, Helen H

    2017-12-01

    Adult mesenchymal stem cells (MSCs) are an attractive cell source for regenerative medicine because of their ability to self-renew and their capacity for multilineage differentiation and tissue regeneration. For connective tissues, such as ligaments or tendons, MSCs are vital to the modulation of the inflammatory response following acute injury while also interacting with resident fibroblasts to promote cell proliferation and matrix synthesis. To date, MSC injection for connective tissue repair has yielded mixed results in vivo, likely due to a lack of appropriate environmental cues to effectively control MSC response and promote tissue healing instead of scar formation. In healthy tissues, stem cells reside within a complex microenvironment comprising cellular, structural, and signaling cues that collectively maintain stemness and modulate tissue homeostasis. Changes to the microenvironment following injury regulate stem cell differentiation, trophic signaling, and tissue healing. Here, we focus on models of the stem cell microenvironment that are used to elucidate the mechanisms of stem cell regulation and inspire functional approaches to tissue regeneration. Recent studies in this frontier area are highlighted, focusing on how microenvironmental cues modulate MSC response following connective tissue injury and, more importantly, how this unique cell environment can be programmed for stem cell-guided tissue regeneration. © 2017 New York Academy of Sciences.

  12. Design and Experimental Verification of Chang'E-3 Moon-night Survival Device for APXS

    Science.gov (United States)

    Deng-yi, Chen; Jian, Wu; Yi-ming, Hu; Jin, Chang; Yi-zhong, Gong; Ming-sheng, Cai; Huan-yu, Wang; Jia-yu, Zhang; Xing-zhu, Cui; Jin-zhou, Wang

    2016-07-01

    The Active Particle X-ray Spectrometer (APXS) is one of the 4 scientific payloads of Chang'E-3 (CE-3) Lunar Rover, of which the scientific object is to identify the elements of lunar soil and rock samples by a carried radioactive source to trigger and detect the characteristic X-ray from them. According to the extreme temperature environment of the APXS and under the restriction of limited resources, this paper presents the design and analysis of the moon-night survival device RHU (radioisotope heating unit) for the APXS, and describes the corresponding environmental tests on its structure dynamics and moon-night survival. Finally, its reinstallation on the launch tower and the preliminary result of its on-orbit operation are introduced.

  13. Guided exploration of physically valid shapes for furniture design

    KAUST Repository

    Umetani, Nobuyuki

    2012-07-01

    Geometric modeling and the physical validity of shapes are traditionally considered independently. This makes creating aesthetically pleasing yet physically valid models challenging. We propose an interactive design framework for efficient and intuitive exploration of geometrically and physically valid shapes. During any geometric editing operation, the proposed system continuously visualizes the valid range of the parameter being edited. When one or more constraints are violated after an operation, the system generates multiple suggestions involving both discrete and continuous changes to restore validity. Each suggestion also comes with an editing mode that simultaneously adjusts multiple parameters in a coordinated way to maintain validity. Thus, while the user focuses on the aesthetic aspects of the design, our computational design framework helps to achieve physical realizability by providing active guidance to the user. We demonstrate our framework on plankbased furniture design with nail-joint and frictional constraints. We use our system to design a range of examples, conduct a user study, and also fabricate a physical prototype to test the validity and usefulness of the system. © 2012 ACM 0730-0301/2012/08- ART86.

  14. GIS cartography a guide to effective map design

    CERN Document Server

    Peterson, Gretchen N

    2014-01-01

    IntroductionOn Design ExperienceConstructive CriticismWhat Is a Geoprofessional?Tick-Tock Goes the ClockWhy Good Design MattersAudienceHow to Use This BookSkipping the How-Tos to Get Straight to the Good StuffRelative Map ScalesEndnotesCreative InspirationYou Can Be CreativeDoingSeeingAn Example of How to SeeApplying All of This to Your MapSummary and Final ProddingCreative MapsA Few Places to Start Seeing Art from Your DesktopEndnotesExerciseLayout DesignAll Together NowLayout ChecklistElement Details and ExamplesStyleContextArrangementEmphasis Maps and WireframesSimplicity versus ComplexityM

  15. Mechanical System Analysis/Design Tool (MSAT) Quick Guide

    Science.gov (United States)

    Lee, HauHua; Kolb, Mark; Madelone, Jack

    1998-01-01

    MSAT is a unique multi-component multi-disciplinary tool that organizes design analysis tasks around object-oriented representations of configuration components, analysis programs and modules, and data transfer links between them. This creative modular architecture enables rapid generation of input stream for trade-off studies of various engine configurations. The data transfer links automatically transport output from one application as relevant input to the next application once the sequence is set up by the user. The computations are managed via constraint propagation - the constraints supplied by the user as part of any optimization module. The software can be used in the preliminary design stage as well as during the detail design of product development process.

  16. Making maps a visual guide to map design for GIS

    CERN Document Server

    Krygier, John

    2016-01-01

    Lauded for its accessibility and beautiful design, this text has given thousands of students and professionals the tools to create effective, compelling maps. Using a wealth of illustrations--with 74 in full color--to elucidate each concisely presented point, the revised and updated third edition continues to emphasize how design choices relate to the reasons for making a map and its intended purpose. All components of map making are covered: titles, labels, legends, visual hierarchy, font selection, how to turn phenomena into visual data, data organization, symbolization, and more. Innovative

  17. Geomatics engineering a practical guide to project design

    CERN Document Server

    Ogaja, Clement A

    2010-01-01

    OVERVIEWProject Design ProcessUnderstanding Project RequirementsInformation GatheringDesign ApproachesScheduling and Cost EstimatingWriting ProposalsBibliographyExercises CONTEMPORARY ISSUESStandards and SpecificationsDefinitionsApplication Modes of a StandardUnits of MeasureAccuracy versus PrecisionEquipment SpecificationsLimits of ClosureLeast Squares AnalysisMapping and GIS StandardsClassical Surveying StandardsGPS Surveying StandardsOther StandardsBibliography ExercisesProfessional and Ethical ResponsibilitiesKnow What You DoEthics and Professional Conduct Individual and Team Responsibilit

  18. User's guide to designing and mounting lenses and mirrors

    International Nuclear Information System (INIS)

    Kowalskie, B.J.

    1978-01-01

    The guidebook is a practitioner-oriented supplement to standard texts in optics and mechanical engineering. It reflects practical experience with the oftentimes troublesome aspects of effectively integrating optical components with mechanical hardware. Accordingly, its focus is on the techniques, assumptions, and levels of design sophistication needed for a wide variety of sizes and optical surface quality levels. It is intended to be a primer for engineers, designers, and draftsmen already familiar with some of the problems encountered in mounting optical components and who are responsible for developing components for high-energy laser systems

  19. Remote Maintenance Design Guide for Compact Processing Units

    Energy Technology Data Exchange (ETDEWEB)

    Draper, J.V.

    2000-07-13

    Oak Ridge National Laboratory (ORNL) Robotics and Process Systems (RPSD) personnel have extensive experience working with remotely operated and maintained systems. These systems require expert knowledge in teleoperation, human factors, telerobotics, and other robotic devices so that remote equipment may be manipulated, operated, serviced, surveyed, and moved about in a hazardous environment. The RPSD staff has a wealth of experience in this area, including knowledge in the broad topics of human factors, modular electronics, modular mechanical systems, hardware design, and specialized tooling. Examples of projects that illustrate and highlight RPSD's unique experience in remote systems design and application include the following: (1) design of a remote shear and remote dissolver systems in support of U.S. Department of Energy (DOE) fuel recycling research and nuclear power missions; (2) building remotely operated mobile systems for metrology and characterizing hazardous facilities in support of remote operations within those facilities; (3) construction of modular robotic arms, including the Laboratory Telerobotic Manipulator, which was designed for the National Aeronautics and Space Administration (NASA) and the Advanced ServoManipulator, which was designed for the DOE; (4) design of remotely operated laboratories, including chemical analysis and biochemical processing laboratories; (5) construction of remote systems for environmental clean up and characterization, including underwater, buried waste, underground storage tank (UST) and decontamination and dismantlement (D&D) applications. Remote maintenance has played a significant role in fuel reprocessing because of combined chemical and radiological contamination. Furthermore, remote maintenance is expected to play a strong role in future waste remediation. The compact processing units (CPUs) being designed for use in underground waste storage tank remediation are examples of improvements in systems

  20. Variation-Aware Design of Custom Integrated Circuits A Hands-on Field Guide A Hands-on Field Guide

    CERN Document Server

    McConaghy, Trent; Dyck, Jeffrey; Gupta, Amit

    2013-01-01

    This book targets custom IC designers who are encountering variation issues in their designs, especially for modern process nodes at 45nm and below, such as statistical process variations, environmental variations, and layout effects.  The authors have created a field guide to show how to handle variation proactively, and to understand the benefits of doing so. Readers facing variation challenges in their memory, standard cell, analog/RF, and custom digital designs will find easy-to-read, pragmatic solutions.   Reviews the most important concepts in variation-aware design, including types of variables and variation, useful variation-aware design terminology, and an overview and comparison of high-level design flows. Describes and compares a suite of approaches and flows for PVT corner-driven design and verification. Presents Fast PVT, a novel, confidence-driven global optimization technique for PVT corner extraction and verification that is both rapid and reliable. Presents a visually-oriented overview of ...

  1. Elements and Principles of Design Posters. Teacher's Guide.

    Science.gov (United States)

    1996

    This book accompanies a poster series and allows the teacher to pre-plan a lesson or activity for students with the objectives shown for each element or principle of design to be presented. Along with a black-and-white reproduction of each poster, major concepts are discussed. Suggested student activities relating to a particular element or…

  2. Pharmacokinetic-pharmacodynamic guided trial design in oncology

    NARCIS (Netherlands)

    van Kesteren, Ch; Mathôt, R. A. A.; Beijnen, J. H.; Schellens, J. H. M.

    2003-01-01

    The application of pharmacokinetic (PK) and pharmacodynamic (PD) modeling in drug development has emerged during the past decades and it is has been suggested that the investigation of PK-PD relationships during drug development may facilitate and optimize the design of subsequent clinical

  3. A Prospective Method to Guide Small Molecule Drug Design

    Science.gov (United States)

    Johnson, Alan T.

    2015-01-01

    At present, small molecule drug design follows a retrospective path when considering what analogs are to be made around a current hit or lead molecule with the focus often on identifying a compound with higher intrinsic potency. What this approach overlooks is the simultaneous need to also improve the physicochemical (PC) and pharmacokinetic (PK)…

  4. Mixing ventilation guide on mixing air distribution design

    CERN Document Server

    Kandzia, Claudia; Kosonen, Risto; Krikor Melikov, Arsen; Nielsen, Peter Vilhelm

    2013-01-01

    In this guidebook most of the known and used in practice methods for achieving mixing air distribution are discussed. Mixing ventilation has been applied to many different spaces providing fresh air and thermal comfort to the occupants. Today, a design engineer can choose from large selection of air diffusers and exhaust openings.

  5. Mixing Ventilation. Guide on mixing air distribution design

    DEFF Research Database (Denmark)

    Kandzia, Claudia; Kosonen, Risto; Melikov, Arsen Krikor

    In this guidebook most of the known and used in practice methods for achieving mixing air distribution are discussed. Mixing ventilation has been applied to many different spaces providing fresh air and thermal comfort to the occupants. Today, a design engineer can choose from large selection...

  6. The Packaging Handbook -- A guide to package design

    International Nuclear Information System (INIS)

    Shappert, L.B.

    1995-01-01

    The Packaging Handbook is a compilation of 14 technical chapters and five appendices that address the life cycle of a packaging which is intended to transport radioactive material by any transport mode in normal commerce. Although many topics are discussed in depth, this document focuses on the design aspects of a packaging. The Handbook, which is being prepared under the direction of the US Department of Energy, is intended to provide a wealth of technical guidance that will give designers a better understanding of the regulatory approval process, preferences of regulators in specific aspects of packaging design, and the types of analyses that should be seriously considered when developing the packaging design. Even though the Handbook is concerned with all packagings, most of the emphasis is placed on large packagings that are capable of transporting large radioactive sources that are also fissile (e.g., spent fuel). These are the types of packagings that must address the widest range of technical topics in order to meet domestic and international regulations. Most of the chapters in the Handbook have been drafted and submitted to the Oak Ridge National Laboratory for editing; the majority of these have been edited. This report summarizes the contents

  7. An Integrated User Interface Style Guide for the ESF-CCS, RPS and CPCS display design

    International Nuclear Information System (INIS)

    Park, Jae Kyu; Lee, Hyun Chul; Hwang, Seong Hwan; Jang, Tong Il; Kang, Suk Ho; Lee, Jung Woon; Lee, Yong Hee

    2009-01-01

    The human machine interface (HMI) design process is important to enhance the safety and reliability of a Nuclear Power Plant (NPP) operation. Various MMI activities are achieved with progress of MMI and environment of NPP. These activities are impossible to utilize when upgrade of environment because most of these activities emphasize hardware aspect. Also, the human factors guidelines mostly describe the human factors principles so the designer has to adapt them to apply them to his design. The design-specific guideline that is specially dedicated to a unique system and derived from the general guidelines is called style guide. The style guide provides easy to use templates to help the user interface design, and these templates help ensure a consistent look and behavior throughout the design products. However, it could be difficult for a designer to select the human factors guideline items related to a target system and to derive a style guide from the items. This paper describes human factors activities carried out to develop a style guide for the ESF-CCS, RPS and CPCS system

  8. Development of customized positioning guides using computer-aided design and manufacturing technology for orthognathic surgery.

    Science.gov (United States)

    Lin, Hsiu-Hsia; Chang, Hsin-Wen; Lo, Lun-Jou

    2015-12-01

    The purpose of this study was to devise a method for producing customized positioning guides for translating virtual plans to actual orthognathic surgery, and evaluation of the feasibility and validity of the devised method. Patients requiring two-jaw orthognathic surgery were enrolled and consented before operation. Two types of positioning guides were designed and fabricated using computer-aided design and manufacturing technology: One of the guides was used for the LeFort I osteotomy, and the other guide was used for positioning the maxillomandibular complex. The guides were fixed to the medial side of maxilla. For validation, the simulation images and postoperative cone beam computed tomography images were superimposed using surface registration to quantify the difference between the images. The data were presented in root-mean-square difference (RMSD) values. Both sets of guides were experienced to provide ideal fit and maximal contact to the maxillary surface to facilitate their accurate management in clinical applications. The validation results indicated that RMSD values between the images ranged from 0.18 to 0.33 mm in the maxilla and from 0.99 to 1.56 mm in the mandible. The patients were followed up for 6 months or more, and all of them were satisfied with the results. The proposed customized positioning guides are practical and reliable for translation of virtual plans to actual surgery. Furthermore, these guides improved the efficiency and outcome of surgery. This approach is uncomplicated in design, cost-effective in fabrication, and particularly convenient to use.

  9. Research and development on the hydraulic design system of the guide vanes of multistage centrifugal pumps

    International Nuclear Information System (INIS)

    Zhang, Q H; Xu, Y; Shi, W D; Lu, W G

    2012-01-01

    To improve the hydraulic design accuracy and efficiency of the guide vanes of the multistage centrifugal pumps, four different-structured guide vanes are investigated, and the design processes of those systems are established. The secondary development platforms of the ObjectArx2000 and the UG/NX OPEN are utilized to develop the hydraulic design systems of the guide vanes. The error triangle method is adopted to calculate the coordinates of the vanes, the profiles of the vanes are constructed by Bezier curves, and then the curves of the flow areas along the flow-path are calculated. Two-dimensional and three-dimensional hydraulic models can be developed by this system.

  10. Best Practices Guide for Energy-Efficient Data Center Design: Revised March 2011 (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2011-03-01

    This guide provides an overview of best practices for energy-efficient data center design which spans the categories of Information Technology (IT) systems and their environmental conditions, data center air management, cooling and electrical systems, on-site generation, and heat recovery. IT system energy efficiency and environmental conditions are presented first because measures taken in these areas have a cascading effect of secondary energy savings for the mechanical and electrical systems. This guide concludes with a section on metrics and benchmarking values by which a data center and its systems energy efficiency can be evaluated. No design guide can offer 'the most energy-efficient' data center design but the guidelines that follow offer suggestions that provide efficiency benefits for a wide variety of data center scenarios.

  11. A revision of the cask designers guide for the '90s

    International Nuclear Information System (INIS)

    Shappert, L.B.; Green, V.M.

    1993-01-01

    DOE has requested that ORNL initiate a revision to NSIC-68, A Guide for the Design, Fabrication, and Operation of Shipping Casks for Nuclear Applications, commonly called the Cask Designers Guide. This revision, called the Cask Handbook, has two goals: (1) to improve the quality of SARPs that are submitted to DOE, and (2) to provide up-to-date information on the design of spent fuel shipping casks, including information on fabrication, quality assurance, SARP preparation, certification, use, maintenance, and other general topics. The revision provides guidance that will help engineers through the cask licensing process, in part, by providing as much regulator-approved data and 'lessons-learned' information as possible. The effort is sponsored by DOE-Environmental, Safety and Health (EH), guided by Transportation Technology staff members at ORNL, and the information is being generated by experts in the various technical fields. (J.P.N.)

  12. Optical design of the adaptive optics laser guide star system

    Energy Technology Data Exchange (ETDEWEB)

    Bissinger, H. [Lawrence Livermore National Lab., CA (United States)

    1994-11-15

    The design of an adaptive optics package for the 3 meter Lick telescope is presented. This instrument package includes a 69 actuator deformable mirror and a Hartmann type wavefront sensor operating in the visible wavelength; a quadrant detector for the tip-tile sensor and a tip-tilt mirror to stabilize atmospheric first order tip-tile errors. A high speed computer drives the deformable mirror to achieve near diffraction limited imagery. The different optical components and their individual design constraints are described. motorized stages and diagnostics tools are used to operate and maintain alignment throughout observation time from a remote control room. The expected performance are summarized and actual results of astronomical sources are presented.

  13. Design of the reactor coolant system and associated systems in nuclear power plants. Safety guide

    International Nuclear Information System (INIS)

    2008-01-01

    This Safety Guide was prepared under the IAEA programme for establishing safety standards for nuclear power plants. The basic requirements for the design of safety systems for nuclear power plants are established in the Safety Requirements publication, Safety Standards Series No. NS-R-1 on Safety of Nuclear Power Plants: Design, which it supplements. This Safety Guide describes how the requirements for the design of the reactor coolant system (RCS) and associated systems in nuclear power plants should be met. 1.2. This publication is a revision and combination of two previous Safety Guides, Safety Series No. 50-SG-D6 on Ultimate Heat Sink and Directly Associated Heat Transport Systems for Nuclear Power Plants (1981), and Safety Series No. 50-SG-D13 on Reactor Coolant and Associated Systems in Nuclear Power Plants (1986), which are superseded by this new Safety Guide. 1.3. The revision takes account of developments in the design of the RCS and associated systems in nuclear power plants since the earlier Safety Guides were published in 1981 and 1986, respectively. The other objectives of the revision are to ensure consistency with Ref., issued in 2000, and to update the technical content. In addition, an appendix on pressurized heavy water reactors (PHWRs) has been included

  14. Protection against internal fires and explosions in the design of nuclear power plants. Safety guide

    International Nuclear Information System (INIS)

    2004-01-01

    Experience of the past two decades in the operation of nuclear power plants and modern analysis techniques confirm that fire may be a real threat to nuclear safety and should receive adequate attention from the beginning of the design process throughout the life of the plant. Within the framework of the NUSS programme, a Safety Guide on fire protection had therefore been developed to enlarge on the general requirements given in the Code. Since its first publication in 1979, there has been considerable development in protection technology and analysis methods and after the Chernobyl accident it was decided to revise the existing Guide. This Safety Guide supplements the requirements established in Safety of Nuclear Power Plants: Design. It supersedes Safety Series No. 50-SG-D2 (Rev. 1), Fire Protection in Nuclear Power Plants: A Safety Guide, issued in 1992.The present Safety Guide is intended to advise designers, safety assessors and regulators on the concept of fire protection in the design of nuclear power plants and on recommended ways of implementing the concept in some detail in practice

  15. Socio-technical Spaces: Guiding Politics, Staging Design

    DEFF Research Database (Denmark)

    Clausen, Christian; Yoshinaka, Yutaka

    2005-01-01

    This article addresses how insights from the social shaping tradition and political process theory may contribute to an understanding of the sociotechnical design and implementation of change. This idea is pursued through the notion of 'socio-technical spaces' and its delineation, with respect...... political concerns. The paper tentatively points to some analytical implications and to challenges and possibilities for the 'bridging' between spaces otherwise rendered distinct....

  16. Novel implant design improves implant survival in multirooted extraction sites: a preclinical pilot study.

    Science.gov (United States)

    Sivan-Gildor, Adi; Machtei, Eli E; Gabay, Eran; Frankenthal, Shai; Levin, Liran; Suzuki, Marcelo; Coelho, Paulo G; Zigdon-Giladi, Hadar

    2014-10-01

    The primary aim is to evaluate clinical, radiographic, and histologic parameters of novel implants with "three roots" design that were inserted into fresh multirooted extraction sockets. A secondary aim is to compare this new implant to standard root-form dental implants. Immediate implantation of novel or standard design 6 × 6-mm implants was performed bilaterally into multirooted sockets in mandibles of mini-pigs. Twelve weeks later, clinical, radiographic, stability, histomorphometric, and microcomputed tomography (micro-CT) analyses were performed. Survival rates were significantly higher in the test implants compared with control (92.8% versus 33.3%, respectively; P micro-CT analyses demonstrated bone fill in the inner part of the test implants. Moreover, bone-to-implant contact was higher in the test implants (55.50% ± 3.68% versus 42.47% ± 9.89%). Contrary to the clinical, radiographic, and histomorphometric results, resonance frequency analysis measurements were greater in the control group (77.74 ± 3.21 implant stability quotient [ISQ]) compared with the test group (31.09 ± 0.28 ISQ), P = 0.008. The novel design implants resulted in significantly greater survival rate in multirooted extraction sites. Further studies will be required to validate these findings.

  17. Using QA classification to guide design and manage risk

    International Nuclear Information System (INIS)

    Lathrop, J.; DeKlever, R.; Petrie, E.H.

    1993-01-01

    Raytheon Services Nevada has developed a classification process based on probabilistic risk assessment, using accident/impact scenarios for each system classified. Initial classification analyses were performed for the 20 systems of Package IA of the Exploratory Studies Facility (ESF). The analyses demonstrated a solid, defensible methodological basis for classification which minimizes the use of direct engineering judgment. They provide guidance for ESF design and risk management through the identification of: The critical characteristics of each system that need to be controlled; and the parts of the information base that most need to be further developed through performance assessment or other efforts

  18. Google SketchUp for Game Design Beginner's Guide

    CERN Document Server

    de Jongh, Robin

    2011-01-01

    The book takes a clear, step-by-step approach to building a complete game level using SketchUp with many props and textures. This book is designed for anyone who wants to create entire 3D worlds in freely available game engines such as Unity 3D, CryEngine, Ogre, Panda3D, Unreal Engine, and Blender Game Engine. It also targets all those who wish to create new levels and assets to sell in game asset stores or use in visualization or animation.

  19. Design and construction of wave guide CO2 laser

    International Nuclear Information System (INIS)

    Al-Ali, M.S.

    1989-01-01

    This thesis describes the design, construction and operation of a countinous wave (CW) CO2 waveguide laser with axial gas flow in which the multi-electrode technique was used to achieve uniform volume of ionized gas using two and four pairs of electrodes. Resonators of lengths ( 26 - 47.5 ) cm with inside diameter ( 3 - 4 ) mm were used with discharge taking place between four pairs of electordes 8.25 cm long each, in axial direction of the tube. The avearge flow at the tube outlet was ( 5 - 6.5 ) L/min at different gas pressures. ( 4 tabs., 74 figs., 58 refs. )

  20. Design guides for cell atmosphere controls, utilities and fire protection

    International Nuclear Information System (INIS)

    Hill, A.J. Jr.; Peishel, F.L.; Slattery, E.F.

    1981-01-01

    Facilities for handling radioactive and toxic materials must be designed not only for efficient operation, but also for protection of the operating personnel and the public. The ventilation system is of primary importance in maintaining containment of any airborne radioactivity. The type, number, and location of in-cell services must be adequate for planned operations, but also must allow flexibility to accommodate expansion in the scope of operations or changes in programs. Fire protection systems and operational controls are mandatory to maintain containment of radioactivity in the event of an operating error or process accident that may result in a fire

  1. Guide to radiological accident considerations for siting and design of DOE nonreactor nuclear facilities

    International Nuclear Information System (INIS)

    Elder, J.C.; Graf, J.M.; Dewart, J.M.; Buhl, T.E.; Wenzel, W.J.; Walker, L.J.; Stoker, A.K.

    1986-01-01

    This guide was prepared to provide the experienced safety analyst with accident analysis guidance in greater detail than is possible in Department of Energy (DOE) Orders. The guide addresses analysis of postulated serious accidents considered in the siting and selection of major design features of DOE nuclear facilities. Its scope has been limited to radiological accidents at nonreactor nuclear facilities. The analysis steps addressed in the guide lead to evaluation of radiological dose to exposed persons for comparison with siting guideline doses. Other possible consequences considered are environmental contamination, population dose, and public health effects. Choices of models and parameters leading to estimation of source terms, release fractions, reduction and removal factors, dispersion and dose factors are discussed. Although requirements for risk analysis have not been established, risk estimates are finding increased use in siting of major nuclear facilities, and are discussed in the guide. 3 figs., 9 tabs

  2. Guide to the design and application of online questionnaire surveys.

    Science.gov (United States)

    Regmi, Pramod R; Waithaka, Elizabeth; Paudyal, Anjana; Simkhada, Padam; van Teijlingen, Edwin

    2016-12-01

    Collecting research data through traditional approaches (face-to-face, postal or telephone survey) can be costly and time consuming. The emerging data collection approach based on internet/e-based technologies (e.g. online platforms and email), is a relatively cost effective survey alternative. These novel data collection strategies can collect large amounts of data from participants in a short time frame. Similarly, they also seem to be feasible and effective in collecting data on sensitive issues or with samples they are generally hard to reach, for example, men who have sex with men (MSM) or migrants. As a significant proportion of the population currently in the world are digitally connected, the shift from postal (paper-pencil) or telephone towards online survey use in research is in the interests of researchers in academia as well as in the commercial world. However, compared to designing and executing paper version of the questionnaire, there is limited literature to help a starting researcher with the design and a use of online questionnaires. This short paper highlights issues around: a) methodological aspect of online questionnaire survey; b) online survey planning and management; and c) ethical concerns that may arise while using this option. We believe that this paper will be useful for researchers who want to gain knowledge or apply this approach in their research.

  3. A Nurse's Survival Guide to the Ward - Third edition Richards Ann Edwards Sharon A Nurse's Survival Guide to the Ward - Third edition 500pp £19.99 Elsevier 978 0 7020 4603 2 0702046035 [Formula: see text].

    Science.gov (United States)

    2013-05-08

    This guide is a useful 'friend and companion' to keep close at hand. It is an essential reference for nurses, not only on the ward but in every field of practice where patient care is given. In fact, it makes an accessible guide for all healthcare practitioners.

  4. A novel drill design for photoacoustic guided surgeries

    Science.gov (United States)

    Shubert, Joshua; Lediju Bell, Muyinatu A.

    2018-02-01

    Fluoroscopy is currently the standard approach for image guidance of surgical drilling procedures. In addition to the harmful radiation dose to the patient and surgeon, fluoroscopy fails to visualize critical structures such as blood vessels and nerves within the drill path. Photoacoustic imaging is a well-suited imaging method to visualize these structures and it does not require harmful ionizing radiation. However, there is currently no clinical system available to deliver light to occluded drill bit tips. To address this challenge, a prototype drill was designed, built, and tested using an internal light delivery system that allows laser energy to be transferred from a stationary laser source to the tip of a spinning drill bit. Photoacoustic images were successfully obtained with the drill bit submerged in water and with the drill tip inserted into a thoracic vertebra from a human cadaver.

  5. Natural resource management information systems: a guide to design

    Energy Technology Data Exchange (ETDEWEB)

    Tschanz, J.F.; Kennedy, A.S.

    1975-07-01

    Resource management requires the timely supply of intelligible, concise information to facilitate the variety of decisions needed. A distinctive component of information useful in resource management is its spatial content. The first portion of this guidebook sketches the resource management needs for spatial information, indicating not only the variety of resource management contexts, but also the variety of information/data handling approaches that exist. Within this diversity, common structural characteristics for all spatial information/data handling can be perceived, and the remainder of the guidebook outlines the general structure of a resource management information system and a process for designing such a system. Three basic elements of the information system are data base management, data retrieval and processing, and system support. Equally important are the interfaces through which the system is linked to its community of users, data supply, and available information system technology.

  6. Self-designed femoral neck guide pin locator for femoral neck fractures.

    Science.gov (United States)

    Xia, Shengli; Wang, Ziping; Wang, Minghui; Wu, Zuming; Wang, Xiuhui

    2014-01-01

    Closed reduction and fixation with 3 cannulated screws is a widely accepted surgery for the treatment of femoral neck fractures. However, how to obtain optimal screw placement remains unclear. In the current study, the authors designed a guide pin positioning system for femoral neck fracture cannulated screw fixation and examined its application value by comparing it with freehand guide needle positioning and with general guide pin locator positioning provided by equipment manufacturers. The screw reset rate, screw parallelism, triangle area formed by the link line of the entry point of 3 guide pins, and maximum vertical load bearing of the femoral neck after internal fixation were recorded. As expected, the triangle area was largest in the self-designed positioning group, followed by the general positioning group and the freehand positioning group. The difference among the 3 groups was statistically significant (P.05). The authors’ self-designed guide pin positioning system has the potential to accurately insert cannulated screws in femoral neck fractures and may reduce bone loss and unnecessary radiation.

  7. Guided synthesis of accumulative solutions for the conceptual design of an efficient stove working with biomass

    International Nuclear Information System (INIS)

    Álvarez Cabrales, Alexis; Gaskins Espinosa, Benjamín Gabriel; Pérez Rodríguez, Roberto; Simeón Monet, Rolando Esteban

    2014-01-01

    The conceptual design is closely related to a product functional structure and the search of solution principles for its definition. This work exposes an accumulative method for the traceability of the functional structure that implements the guided conceptual synthesis of solutions in the preliminary analysis of this designing process stage. The method constitutes a contribution to Pahls and Beitzs classic design model. In it, the functional information system is manipulated, providing the designer with a help so that he can examine the different solutions that are obtained, giving him the possibility of selecting the most convenient one. The guided analysis of the accumulative solutions synthesis is illustrated by means of the conceptual design of an efficient stove working with biomass. (author)

  8. Aircraft Crash Survival Design Guide. Volume 2. Aircraft Crash Environment and Human Tolerance

    Science.gov (United States)

    1980-01-01

    a whipping action’of the head, and often, impact of the upper torso on the legs, resulting in chest, head, and neck injuries . Head injuries due to...K., at al., COMPARATIVE TOLERANCE FOR CEREBRAL CONCUSSION BY HEAD IMPACT AND WHIPLASH INJURY IN PRIMATES , 1970 International Automobile Safety...FROM HEAD IMPACT AND WHIPLASH IN PRIMATES , Journal of Biomechanics, Vol. 4, 1971, pp. 13-21. 18. Goldsmith, W., BIOMECHANICS OF HEAD INJURY , In

  9. Infrastructure optimisation via MBR retrofit: a design guide.

    Science.gov (United States)

    Bagg, W K

    2009-01-01

    Wastewater management is continually evolving with the development and implementation of new, more efficient technologies. One of these is the Membrane Bioreactor (MBR). Although a relatively new technology in Australia, MBR wastewater treatment has been widely used elsewhere for over 20 years, with thousands of MBRs now in operation worldwide. Over the past 5 years, MBR technology has been enthusiastically embraced in Australia as a potential treatment upgrade option, and via retrofit typically offers two major benefits: (1) more capacity using mostly existing facilities, and (2) very high quality treated effluent. However, infrastructure optimisation via MBR retrofit is not a simple or low-cost solution and there are many factors which should be carefully evaluated before deciding on this method of plant upgrade. The paper reviews a range of design parameters which should be carefully evaluated when considering an MBR retrofit solution. Several actual and conceptual case studies are considered to demonstrate both advantages and disadvantages. Whilst optimising existing facilities and production of high quality water for reuse are powerful drivers, it is suggested that MBRs are perhaps not always the most sustainable Whole-of-Life solution for a wastewater treatment plant upgrade, especially by way of a retrofit.

  10. Clean architecture a craftsman's guide to software structure and design

    CERN Document Server

    Martin, Robert C

    2018-01-01

    By applying universal rules of software architecture, you can dramatically improve developer productivity throughout the life of any software system. Now, building upon the success of his best-selling books Clean Code and The Clean Coder, legendary software craftsman Robert C. Martin (“Uncle Bob”) reveals those rules and helps you apply them. Martin’s Clean Architecture doesn’t merely present options. Drawing on over a half-century of experience in software environments of every imaginable type, Martin tells you what choices to make and why they are critical to your success. As you’ve come to expect from Uncle Bob, this book is packed with direct, no-nonsense solutions for the real challenges you’ll face—the ones that will make or break your projects. Learn what software architects need to achieve—and core disciplines and practices for achieving it Master essential software design principles for addressing function, component separation, and data management See how programming...

  11. Technical Support Document: The Development of the Advanced Energy Design Guide for Highway Lodging Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Wei; Jarnagin, Ronald E.; Gowri, Krishnan; McBride, M.; Liu, Bing

    2008-09-30

    This Technical Support Document (TSD) describes the process and methodology for development of the Advanced Energy Design Guide for Highway Lodgings (AEDG-HL or the Guide), a design guidance document intended to provide recommendations for achieving 30% energy savings in highway lodging properties over levels contained in ANSI/ASHRAE/IESNA Standard 90.1-1999, Energy Standard for Buildings Except Low-Rise Residential Buildings. The AEDG-HL is the fifth in a series of guides being developed by a partnership of organizations, including the American Society of Heating, Refrigerating and Air-Conditioning Engineers, Inc. (ASHRAE), the American Institute of Architects (AIA), the Illuminating Engineering Society of North America (IESNA), the United States Green Buildings Council (USGBC), and the U.S. Department of Energy (DOE).

  12. Survival of various implant-supported prosthesis designs following 36 months of clinical function.

    Science.gov (United States)

    Rodriguez, A M; Orenstein, I H; Morris, H F; Ochi, S

    2000-12-01

    The use of endosseous dental implants to replace natural teeth lost to trauma, dental caries, or periodontal disease has become a predictable form of prosthetic treatment since gaining popularity in the early 1980s. While numerous clinical studies have focused on the survival of implants, few address the survival of different prosthesis designs. Beginning in 1991, 882 prostheses supported by more than 2,900 implants (687 patients) were placed by the Department of Veterans Affairs Dental Implant Clinical Research Group (DICRG). These prostheses were divided into five research strata based on arch location. The recommended design for each stratum was: bar-supported overdenture (maxillary completely edentulous); screw-retained hybrid denture (mandibular completely edentulous); screw-retained fixed partial denture (mandibular and maxillary posterior partially edentulous); and cemented single crown (maxillary anterior single tooth). Alternative overdenture designs were utilized in the edentulous arches when the recommended prosthesis could not be fabricated. Prosthesis success rates for the research strata were calculated for an observation time of up to 36 months following prosthesis placement. Success rates for the maxillary edentulous stratum ranged from 94.6% for the bar-retained overdenture supported by five to six fixtures to 81.8% for the cap-retained overdenture. The mandibular edentulous strata produced success rates of 98.1% for the fixed hybrid prosthesis to 91.7% for the cap-retained prosthesis. Success rates for maxillary and mandibular posterior fixed partial dentures were 94.3% and 92.6%, respectively, while the maxillary anterior single-tooth prosthesis yielded a success rate of 98.1% for the 36-month observation period. The recommended prosthesis designs investigated in this study proved to be reliable, with encouraging success rates for an observation period of 36 months following placement.

  13. Optimization of a hybrid electric power system design for large commercial buildings: An application design guide

    Science.gov (United States)

    Lee, Keun

    Renewable energy in different forms has been used in various applications for survival since the beginning of human existence. However, there is a new dire need to reevaluate and recalibrate the overall energy issue both nationally and globally. This includes, but is not limited to, the finite availability of fossil fuel, energy sustainability with an increasing demand, escalating energy costs, environmental impact such as global warming and green-house gases, to name a few. This dissertation is primarily focused and related to the production and usage of electricity from non-hydro renewable sources. Among non-hydro renewable energy sources, electricity generation from wind and solar energy are the fastest-growing technologies in the United States and in the world. However, due to the intermittent nature of such renewable sources, energy storage devices are required to maintain proper operation of the grid system and in order to increase reliability. A hybrid system, as the name suggests, is a combination of different forms of non-renewable and renewable energy generation, with or without storage devices. Hybrid systems, when applied properly, are able to improve reliability and enhance stability, reduce emissions and noise pollution, provide continuous power, increase operation life, reduce cost, and efficiently use all available energy. In the United States (U.S.), buildings consume approximately 40% of the total primary energy and 74% of the total electricity. Therefore, reduction of energy consumption and improved energy efficiency in U.S. buildings will play a vital role in the overall energy picture. Electrical energy usage for any such building varies widely depending on age (construction technique), electricity and natural gas usage, appearance, location and climate. In this research, a hybrid system including non-renewable and renewable energy generation with storage devices specifically for building applications, is studied in detail. This research deals

  14. Using the DSAP Framework to Guide Instructional Design and Technology Integration in BYOD Classrooms

    Science.gov (United States)

    Wasko, Christopher W.

    2016-01-01

    The purpose of this study was to determine the suitability of the DSAP Framework to guide instructional design and technology integration for teachers piloting a BYOD (Bring Your Own Device) initiative and to measure the impact the initiative had on the amount and type of technology used in pilot classrooms. Quantitative and qualitative data were…

  15. Guided-Inquiry Labs Using Bean Beetles for Teaching the Scientific Method & Experimental Design

    Science.gov (United States)

    Schlueter, Mark A.; D'Costa, Allison R.

    2013-01-01

    Guided-inquiry lab activities with bean beetles ("Callosobruchus maculatus") teach students how to develop hypotheses, design experiments, identify experimental variables, collect and interpret data, and formulate conclusions. These activities provide students with real hands-on experiences and skills that reinforce their understanding of the…

  16. Guide for design and application of protective instrumentation for experiments in the BSR and ORR

    International Nuclear Information System (INIS)

    West, K.W.

    1977-03-01

    This report is a guide for the design and application of protective instrumentation for experiments that are to be operated in the Bulk Shielding Reactor (BSR) or the Oak Ridge Research Reactor (ORR) and are to be connected to the reactor power-reduction and alarm systems

  17. [Research on the designing method of a special shade guide for tooth whitening].

    Science.gov (United States)

    Xu, Yingxin

    2015-10-01

    To investigate a method of designing an accurate and scientific shade guide, especially used for judging the effect of tooth whitening, by analyzing the colorimetric values of discolored teeth statistically. One hundred thirty-six pictures of patients who had been receiving the Beyond cold light whitening treatment from February 2009 to July 2014 were analyzed, including 25 tetracycline teeth, 61 mottled-enamel teeth, and 50 yellow teeth. The colorimetric values of discolored teeth were measured. The L* values of shade tabs were calculated by hierarchical clustering of those of discolored teeth. The a* and b* values of shade tabs were the mean of those observed for discolored teeth. Accordingly, different shade guides were designed for each type of discolored teeth, and the effects were evaluated. A statistically significant difference in colorimetric values was found among the three types of discolored teeth. Compared with the Vitapan Classical shade guide, the shade guides designed through the present method were more scientific and accurate in judging the effect of tooth whitening. Moreover, the arrangement of shade tabs was more logical, and the color difference between shade tabs and discolored teeth was smaller. The proposed designing method is theoretically feasible, although its clinical effect has yet to be proven.

  18. Guided Design: Sensitivity to Black-White Interactions When Giving Nursing Care.

    Science.gov (United States)

    Fernandez, Theresa M.

    This paper discusses the use of guided design with white student nurses at the Medical College of Virginia Nursing School to help them develop an awareness of and reduce stereotypic responses when they are providing nursing care to black patients. The need for this type of training for both faculty and students is discussed, a series of seminars…

  19. Design and control of automated guided vehicle systems: A case study

    NARCIS (Netherlands)

    Li, Q.; Adriaansen, A.C.; Udding, J.T.; Pogromski, A.Y.

    2011-01-01

    In this paper, we study the design and control of automated guided vehicle (AGV) systems, with the focus on the quayside container transport in an automated container terminal. We first set up an event-driven model for an AGV system in the zone control framework. Then a number of layouts of the road

  20. Technical Support Document: The Development of the Advanced Energy Design Guide for Small Retail Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Bing; Jarnagin, Ronald E.; Winiarski, David W.; Jiang, Wei; McBride, Merle F.; Crall, C.

    2006-09-30

    The Advanced Energy Design Guide for Small Retail Buildings (AEDG-SR) was developed by a partnership of organizations, including the American Society of Heating, Refrigerating and Air Conditioning Engineers (ASHRAE), the American Institute of Architects (AIA), the Illuminating Engineering Society of North America (IESNA), the United States Green Buildings Council (USGBC), and the Department of Energy (DOE). The guide is intended to offer recommendations to achieve 30% energy savings and thus to encourage steady progress towards net-zero energy buildings. The baseline level energy use was set at buildings built at the turn of the millennium, which are assumed to be based on ANSI/ASHRAE/IESNA Standard 90.1-1999, Energy Standard for Buildings Except Low-Rise Residential Buildings (refer to as the ?Standard? in this report). ASHRAE and its partners are engaged in the development of a series of guides for small commercial buildings, with the AEDG-SR being the second in the series. Previously the partnership developed the Advanced Energy Design Guide for Small Office Buildings: Achieving 30% Energy Savings Over ANSI/ASHRAE/IESNA Standard 90.1-1999, which was published in late 2004. The technical support document prepared by PNNL details how the energy analysis performed in support of the Guide and documents development of recommendation criteria.

  1. Design and Production of an Articulating Needle Guide for Ultrasound-Guided Needle Block Manufactured With a Three-Dimensional Printer: Technical Communication.

    Science.gov (United States)

    Bigeleisen, Paul E

    2017-05-15

    Needle guides may allow the practitioner to align the needle with the probe when ultrasound-guided nerve block is performed. The author's goal was to design and fabricate an inexpensive ($1.90), disposable, needle guide that could articulate over a range from 85 degrees to 0 degrees with a three-dimension printer. Three-dimensional representations of an L50, L25, and C 60 ultrasound probe (Sono Site, Bothell, WA) were created using a laser scanner. Computer-aided design software (Solid Works, Waltham, MA) was used to design a needle bracket and needle guide to attach to these probes. A three-dimensional printer was used to fabricate the needle bracket and guide with acrylonitrile polybutadiene polystyrene. An echogenic needle was held in plane with the needle guide. The author performed a supraclavicular block in a morbidly obese patient. The needle was easily visualized. Similar guides that are commercially available cost as much as $400. A knowledge of computer-aided design is necessary for this work.

  2. Comparison of the General Electric BWR/6 standard plant design to the IAEA NUSS codes and guides

    International Nuclear Information System (INIS)

    D'Ardenne, W.H.; Sherwood, G.G.

    1985-01-01

    The General Electric BWR/6 Mark III standard plant design meets or exceeds current requirements of published International Atomic Energy Agency (IAEA) Nuclear Safety Standards (NUSS) codes and guides. This conclusion is based on a review of the NUSS codes and guides by General Electric and by the co-ordinated US review of the NUSS codes and guides during their development. General Electric compared the published IAEA NUSS codes and guides with the General Electric design. The applicability of each code and guide to the BWR/6 Mark III standard plant design was determined. Each code or guide was reviewed by a General Electric engineer knowledgeable about the structures, systems and components addressed and the technical area covered by that code or guide. The results of this review show that the BWR/6 Mark III standard plant design meets or exceeds the applicable requirements of the published IAEA NUSS codes and guides. The co-ordinated US review of the IAEA NUSS codes and guides corroborates the General Electric review. In the co-ordinated US review, the USNRC and US industry organizations (including General Electric) review the NUSS codes and guides during their development. This review ensures that the NUSS codes and guides are consistent with the current US government regulations, guidance and regulatory practices, US voluntary industry codes and standards, and accepted US industry design, construction and operational practices. If any inconsistencies are identified, comments are submitted to the IAEA by the USNRC. All US concerns submitted to the IAEA have been resolved. General Electric design reviews and the Final Design Approval (FDA) issued by the USNRC have verified that the General Electric BWR/6 Mark III standard plant design meets or exceeds the current US requirements, guidance and practices. Since these requirements, guidance and practices meet or exceed those of the NUSS codes and guides, so does the General Electric design. (author)

  3. User Experience Re-Mastered Your Guide to Getting the Right Design

    CERN Document Server

    Wilson, Chauncey

    2009-01-01

    Good user interface design isn’t just about aesthetics or using the latest technology. Designers also need to ensure their product is offering an optimal user experience. This requires user needs analysis, usability testing, persona creation, prototyping, design sketching, and evaluation through-out the design and development process. User Experience Re-Mastered takes tried and tested material from best-selling books in Morgan Kaufmann’s Series in Interactive Technologies and presents it in typical project framework. Chauncey Wilson guides the reader through each chapter, introducing each stag

  4. Invited review article: high-speed flexure-guided nanopositioning: mechanical design and control issues.

    Science.gov (United States)

    Yong, Y K; Moheimani, S O R; Kenton, B J; Leang, K K

    2012-12-01

    Recent interest in high-speed scanning probe microscopy for high-throughput applications including video-rate atomic force microscopy and probe-based nanofabrication has sparked attention on the development of high-bandwidth flexure-guided nanopositioning systems (nanopositioners). Such nanopositioners are designed to move samples with sub-nanometer resolution with positioning bandwidth in the kilohertz range. State-of-the-art designs incorporate uniquely designed flexure mechanisms driven by compact and stiff piezoelectric actuators. This paper surveys key advances in mechanical design and control of dynamic effects and nonlinearities, in the context of high-speed nanopositioning. Future challenges and research topics are also discussed.

  5. Users' guide to system dynamics model describing Coho salmon survival in Olema Creek, Point Reyes National Seashore, Marin County, California

    Science.gov (United States)

    Woodward, Andrea; Torregrosa, Alicia; Madej, Mary Ann; Reichmuth, Michael; Fong, Darren

    2014-01-01

    The system dynamics model described in this report is the result of a collaboration between U.S. Geological Survey (USGS) scientists and National Park Service (NPS) San Francisco Bay Area Network (SFAN) staff, whose goal was to develop a methodology to integrate inventory and monitoring data to better understand ecosystem dynamics and trends using salmon in Olema Creek, Marin County, California, as an example case. The SFAN began monitoring multiple life stages of coho salmon (Oncorhynchus kisutch) in Olema Creek during 2003 (Carlisle and others, 2013), building on previous monitoring of spawning fish and redds. They initiated water-quality and habitat monitoring, and had access to flow and weather data from other sources. This system dynamics model of the freshwater portion of the coho salmon life cycle in Olema Creek integrated 8 years of existing monitoring data, literature values, and expert opinion to investigate potential factors limiting survival and production, identify data gaps, and improve monitoring and restoration prescriptions. A system dynamics model is particularly effective when (1) data are insufficient in time series length and/or measured parameters for a statistical or mechanistic model, and (2) the model must be easily accessible by users who are not modelers. These characteristics helped us meet the following overarching goals for this model: Summarize and synthesize NPS monitoring data with data and information from other sources to describe factors and processes affecting freshwater survival of coho salmon in Olema Creek. Provide a model that can be easily manipulated to experiment with alternative values of model parameters and novel scenarios of environmental drivers. Although the model describes the ecological dynamics of Olema Creek, these dynamics are structurally similar to numerous other coastal streams along the California coast that also contain anadromous fish populations. The model developed for Olema can be used, at least as a

  6. Guide to radiological accident considerations for siting and design of DOE nonreactor nuclear facilities

    International Nuclear Information System (INIS)

    Elder, J.; Graf, J.M.

    1984-01-01

    DOE Office of Nuclear Safety has sponsored preparation of a guidance document to aid field offices and contractors in their analyses of consequences of postulated major accidents. The guide addresses the requirements of DOE Orders 5480.1A, Chapter V, and 6430.1, including the general requirement that DOE nuclear facilities be sited, designed, and operated in accordance with standards, codes, and guides consistent with those applied to comparable licensed nuclear facilities. The guide includes both philosophical and technical information in the areas of: siting guidelines doses applied to an offsite reference person; consideration also given to an onsite reference person; physical parameters, models, and assumptions to be applied when calculating doses for comparison to siting criteria; and potential accident consequences other than radiological dose to a reference person which might affect siting and major design features of the facility, such as environmental contamination, population dose, and associated public health effects. Recommendations and/or clarifications are provided where this could be done without adding new requirements. In this regard, the guide is considered a valuable aid to the safety analyst, especially where requirements have been subject to inconsistent interpretation or where analysis methods are in transition, such as use of dose model (ICRP 2 or ICRP 30) or use of probabilistic methods of risk analysis in the siting and design of nuclear facilities

  7. Novel study guides for biochemistry meaningful learning in biology: a design-based research

    Directory of Open Access Journals (Sweden)

    Caetano da Costa

    2017-12-01

    Full Text Available To address the usually decontextualized transmission of information in biochemistry teaching, three interventions in a discipline (Metabolism for Biology majors were applied as innovative study guides. We describe the development, application, and evaluation of two study guides, contextualized with a real problem or an integrative view, using broad themes like evolution and metabolic adaptation. In order to evaluate the impact of both interventions on interest, motivation, and learning of the metabolic pathways, a design-based research with cycles of application and assessment was carried out, by means of classroom observation, grade analysis in written exams, and students’ interviews. Analysis and interpretation of the results point to benefits for teaching and learning, with helpful information to guide elaboration and refinement of new teaching materials and to make active learning more meaningful.

  8. Design of Instrumentation and Control Systems for Nuclear Power Plants. Specific Safety Guide

    International Nuclear Information System (INIS)

    2016-01-01

    This publication is a revision and combination of two Safety Guides, IAEA Safety Standards Series No. NS-G-1.1 and No. NS-G-1.3. The revision takes into account developments in instrumentation and control (I&C) systems since the publication of the earlier Safety Guides. The main changes relate to the continuing development of computer applications and the evolution of the methods necessary for their safe, secure and practical use. In addition, account is taken of developments in human factors engineering and the need for computer security. This Safety Guide references and takes into account other IAEA Safety Standards and Nuclear Security Series publications that provide guidance relating to I&C design

  9. A revision of the Cask Designers Guide for the '90s

    International Nuclear Information System (INIS)

    Shappert, L.B.; Green, V.M.

    1992-01-01

    The report A Guide for the Design Fabrication, and Operation of Shipping Casks for Nuclear Applications, ORNL-NSIC-68, commonly called the Cask Designers Guide, is being revised at the request of the Transportation and Packaging Safety Division of the Department of Energy (DOE). The new document will be called the Packaging Handbook. The Cask Designers Guide was published in 1970 during the period when many radioactive materials packagings were being developed and many technical studies applicable to these packagings were being performed. Since that period, many improvements in packaging design have appeared, designers have improved their calculational techniques, and much effort has gone into applying Quality Assurance (QA) principles to cask development Materials, and their limitations, have surfaced as a very important consideration in the licensing process. While the Packaging Handbook considers all Type B packages, most of the authors' experience lies in the technical areas found in the licensing of spent nuclear fuel (SNF) packagings and this is reflected in the document

  10. Design of reactor containment systems for nuclear power plants. Safety guide

    International Nuclear Information System (INIS)

    2008-01-01

    This Safety Guide was prepared under the IAEA programme for safety standards for nuclear power plants. It is a revision of the Safety Guide on Design of the Reactor Containment Systems in Nuclear Power Plants (Safety Series No. 50-Sg-D1) issued in 1985 and supplements the Safety Requirements publication on Safety of Nuclear Power Plants: Design. The present Safety Guide was prepared on the basis of a systematic review of the relevant publications, including the Safety of Nuclear Power Plants: Design, the Safety fundamentals publication on The Safety of Nuclear Installations, Safety Guides, INSAG Reports, a Technical Report and other publications covering the safety of nuclear power plants. 1.2. The confinement of radioactive material in a nuclear plant, including the control of discharges and the minimization of releases, is a fundamental safety function to be ensured in normal operational modes, for anticipated operational occurrences, in design basis accidents and, to the extent practicable, in selected beyond design basis accidents. In accordance with the concept of defence in depth, this fundamental safety function is achieved by means of several barriers and levels of defence. In most designs, the third and fourth levels of defence are achieved mainly by means of a strong structure enveloping the nuclear reactor. This structure is called the 'containment structure' or simply the 'containment'. This definition also applies to double wall containments. 1.3. The containment structure also protects the reactor against external events and provides radiation shielding in operational states and accident conditions. The containment structure and its associated systems with the functions of isolation, energy management, and control of radionuclides and combustible gases are referred to as the containment systems

  11. Design of reactor containment systems for nuclear power plants. Safety guide

    International Nuclear Information System (INIS)

    2004-01-01

    This Safety Guide was prepared under the IAEA programme for safety standards for nuclear power plants. It is a revision of the Safety Guide on Design of the Reactor Containment Systems in Nuclear Power Plants (Safety Series No. 50-Sg-D1) issued in 1985 and supplements the Safety Requirements publication on Safety of Nuclear Power Plants: Design. The present Safety Guide was prepared on the basis of a systematic review of the relevant publications, including the Safety of Nuclear Power Plants: Design, the Safety fundamentals publication on The Safety of Nuclear Installations, Safety Guides, INSAG Reports, a Technical Report and other publications covering the safety of nuclear power plants. 1.2. The confinement of radioactive material in a nuclear plant, including the control of discharges and the minimization of releases, is a fundamental safety function to be ensured in normal operational modes, for anticipated operational occurrences, in design basis accidents and, to the extent practicable, in selected beyond design basis accidents. In accordance with the concept of defence in depth, this fundamental safety function is achieved by means of several barriers and levels of defence. In most designs, the third and fourth levels of defence are achieved mainly by means of a strong structure enveloping the nuclear reactor. This structure is called the 'containment structure' or simply the 'containment'. This definition also applies to double wall containments. 1.3. The containment structure also protects the reactor against external events and provides radiation shielding in operational states and accident conditions. The containment structure and its associated systems with the functions of isolation, energy management, and control of radionuclides and combustible gases are referred to as the containment systems

  12. Combined CT-guided radiofrequency ablation with systemic chemotherapy improves the survival for nasopharyngeal carcinoma with oligometastasis in liver: Propensity score matching analysis.

    Science.gov (United States)

    Li, Wang; Bai, Yutong; Wu, Ming; Shen, Lujun; Shi, Feng; Sun, Xuqi; Lin, Caijin; Chang, Boyang; Pan, Changchuan; Li, Zhiwen; Wu, Peihong

    2017-08-08

    The aim of this study was to retrospectively compare the treatment efficacy of systemic chemotherapy combined with sequential CT-guided radiofrequency ablation (Chemo-RFA) to chemotherapy alone (Chemo-only) in the management of nasopharyngeal carcinoma (NPC) with liver metastasis. Between 2003 and 2011, 328 NPC patients diagnosed with liver metastasis at Sun Yat-sen University Cancer Center were enrolled. One-to-one matched pairs between Chemo-RFA group with the Chemo-only group were generated using propensity score matching. The associations of treatment modality with overall survival (OS) and progression-free survival (PFS) were determined by Cox regression. Of the patients enrolled, 37 patients (11.8 %) received combined treatment, 291 (82.2) received chemotherapy alone. The patients in Chemo-RFA group were more frequently classified as lower number (≤3) of liver metastatic lesions (Poligometastasis in liver, and should be considered if the ablation is technically feasible.

  13. Design of pressurized water reactors - Guide Nr 22, Release of the 18/07/2017

    International Nuclear Information System (INIS)

    2017-01-01

    Jointly developed by the ASN and IRSN, this guide takes safety requirements for reactor design as defined by the IAEA, and reference levels, safety objectives and recommendations made by the WENRA into account. It addresses aspects related to installation design based on an appropriate application of the in-depth defence principle, as well as aspects related to the nuclear safety demonstration of a design. After an introduction which notably contains specific definitions, this guide presents general design objectives and principles: normal operation, possible incidents and accidents, in-depth defence, barriers, functions aiming at preventing incidents or accidents, general approach to nuclear safety demonstration. It addresses the issue of nuclear safety demonstration: identification and taking into account of events which may affect nuclear safety, reference operating conditions, reference internal and external aggressions excluding malevolent acts, the case of malevolent acts, use of probabilistic safety studies, principles of development of study methods. It presents general recommendations related to design: architecture of safety functions, EIP design, organisational and human dimensions, radiation protection. It also presents, specific recommendations related to barrier design (reactor core and associated devices, primary and secondary circuits, barrier), and to some safety functions (control of chain reactions, confinement of radioactive substances). It finally addresses other specific recommendations related to design: heat evacuation, electricity supply, volumetric and chemical control of the primary coolant, handling and warehousing of nuclear fuel, control and command, crisis management, and management of effluents and of radioactive wastes

  14. A beginner's guide to 3D printing 14 simple toy designs to get you started

    CERN Document Server

    Rigsby, Mike

    2014-01-01

    A Beginner''s Guide to 3D Printing is the perfect resource for those who would like to experiment with 3D design and manufacturing, but have little or no technical experience with the standard software. Author Mike Rigsby leads readers step-by-step through 15 simple toy projects, each illustrated with screen caps of Autodesk 123D Design, the most common free 3D software available. The projects are later described using Sketchup, another free popular software package. Beginning with basics projects that will take longer to print than design, readers are then given instruction on more advanced t

  15. Design Guide for Earth System Science Education: Common Student Learning Objectives and Special Pedagogical Approaches

    Science.gov (United States)

    Baker, D.

    2006-12-01

    As part of the NASA-supported undergraduate Earth System Science Education (ESSE) program, fifty-seven institutions have developed and implemented a wide range of Earth system science (ESS) courses, pedagogies, and evaluation tools. The Teaching, Learning, and Evaluation section of USRA's online ESSE Design Guide showcases these ESS learning environments. This Design Guide section also provides resources for faculty who wish to develop ESS courses. It addresses important course design issues including prior student knowledge and interests, student learning objectives, learning resources, pedagogical approaches, and assessments tied to student learning objectives. The ESSE Design Guide provides links to over 130 ESS course syllabi at introductory, senior, and graduate levels. ESS courses over the past 15 years exhibit common student learning objectives and unique pedagogical approaches. From analysis of ESS course syllabi, seven common student learning objectives emerged: 1) demonstrate systems thinking, 2) develop an ESS knowledge base, 3) apply ESS to the human dimension, 4) expand and apply analytical skills, 5) improve critical thinking skills, 6) build professional/career skills, and 7) acquire an enjoyment and appreciation for science. To meet these objectives, ESSE often requires different ways of teaching than in traditional scientific disciplines. This presentation will highlight some especially successful pedagogical approaches for creating positive and engaging ESS learning environments.

  16. Classifier-guided sampling for discrete variable, discontinuous design space exploration: Convergence and computational performance

    Energy Technology Data Exchange (ETDEWEB)

    Backlund, Peter B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Shahan, David W. [HRL Labs., LLC, Malibu, CA (United States); Seepersad, Carolyn Conner [Univ. of Texas, Austin, TX (United States)

    2014-04-22

    A classifier-guided sampling (CGS) method is introduced for solving engineering design optimization problems with discrete and/or continuous variables and continuous and/or discontinuous responses. The method merges concepts from metamodel-guided sampling and population-based optimization algorithms. The CGS method uses a Bayesian network classifier for predicting the performance of new designs based on a set of known observations or training points. Unlike most metamodeling techniques, however, the classifier assigns a categorical class label to a new design, rather than predicting the resulting response in continuous space, and thereby accommodates nondifferentiable and discontinuous functions of discrete or categorical variables. The CGS method uses these classifiers to guide a population-based sampling process towards combinations of discrete and/or continuous variable values with a high probability of yielding preferred performance. Accordingly, the CGS method is appropriate for discrete/discontinuous design problems that are ill-suited for conventional metamodeling techniques and too computationally expensive to be solved by population-based algorithms alone. In addition, the rates of convergence and computational properties of the CGS method are investigated when applied to a set of discrete variable optimization problems. Results show that the CGS method significantly improves the rate of convergence towards known global optima, on average, when compared to genetic algorithms.

  17. Achieving 50% Energy Savings in New Schools, Advanced Energy Design Guides: K-12 Schools (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2014-09-01

    This fact sheet summarizes recommendations for designing elementary, middle, and high school buildings that will result in 50% less energy use than conventional new schools built to minimum code requirements. The recommendations are drawn from the Advanced Energy Design Guide for K-12 School Buildings, an ASHRAE publication that provides comprehensive recommendations for designing low-energy-use school buildings (see sidebar). Designed as a stand-alone document, this fact sheet provides key principles and a set of prescriptive design recommendations appropriate for smaller schools with insufficient budgets to fully implement best practices for integrated design and optimized performance. The recommendations have undergone a thorough analysis and review process through ASHRAE, and have been deemed the best combination of measures to achieve 50% savings in the greatest number of schools.

  18. Technical Support Document: Development of the Advanced Energy Design Guide for Small Office Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Jarnagin, Ronald E.; Liu, Bing; Winiarski, David W.; McBride, Merle F.; Suharli, L.; Walden, D.

    2006-11-30

    This Technical Support Document (TSD) describes the process and methodology for the development of the Advanced Energy Design Guide for Small Office Buildings (AEDG-SO), a design guidance document intended to provide recommendations for achieving 30% energy savings in small office buildings over levels contained in ANSI/ASHRAE/IESNA Standard 90.1-1999, Energy Standard for Buildings Except Low-Rise Residential Buildings. The AEDG-SO is the first in a series of guides being developed by a partnership of organizations, including the American Society of Heating, Refrigerating and Air-Conditioning Engineers, Inc. (ASHRAE), the American Institute of Architects (AIA), the Illuminating Engineering Society of North America (IESNA), the New Buildings Institute (NBI), and the U.S. Department of Energy (DOE). Each of the guides in the AEDG series will provide recommendations and user-friendly design assistance to designers, developers and owners of small commercial buildings that will encourage steady progress towards net-zero energy buildings. The guides will provide prescriptive recommendation packages that are capable of reaching the energy savings target for each climate zone in order to ease the burden of the design and construction of energy-efficient small commercial buildings The AEDG-SO was developed by an ASHRAE Special Project committee (SP-102) made up of representatives of each of the partner organizations in eight months. This TSD describes the charge given to the committee in developing the office guide and outlines the schedule of the development effort. The project committee developed two prototype office buildings (5,000 ft2 frame building and 20,000 ft2 two-story mass building) to represent the class of small office buildings and performed an energy simulation scoping study to determine the preliminary levels of efficiency necessary to meet the energy savings target. The simulation approach used by the project committee is documented in this TSD along with

  19. Migrations and swimming capabilities of endangered pallid sturgeon (Scaphirhynchus albus) to guide passage designs in the fragmented Yellowstone River

    Science.gov (United States)

    Braaten, P. J.; Elliott, Caroline M.; Rhoten, Jason C.; Fuller, D. B.; McElroy, Brandon J.

    2015-01-01

    Fragmentation of the Yellowstone River is hypothesized to preclude recruitment of endangered Scaphirhynchus albus (pallid sturgeon) by impeding upstream spawning migrations and access to upstream spawning areas, thereby limiting the length of free-flowing river required for survival of early life stages. Building on this hypothesis, the reach of the Yellowstone River affected by Intake Diversion Dam (IDD) is targeted for modification. Structures including a rock ramp and by-pass channel have been proposed as restoration alternatives to facilitate passage. Limited information on migrations and swimming capabilities of pallid sturgeon is available to guide engineering design specifications for the proposed structures. Migration behavior, pathways (channel routes used during migrations), and swimming capabilities of free-ranging wild adult pallid sturgeon were examined using radiotelemetry, and complemented with hydraulic data obtained along the migration pathways. Migrations of 12–26% of the telemetered pallid sturgeon population persisted to IDD, but upstream passage over the dam was not detected. Observed migration pathways occurred primarily through main channel habitats; however, migrations through side channels up to 3.9 km in length were documented. The majority of pallid sturgeon used depths of 2.2–3.4 m and mean water velocities of 0.89–1.83 m/s while migrating. Results provide inferences on depths, velocities, and habitat heterogeneity of reaches successfully negotiated by pallid sturgeon that may be used to guide designs for structures facilitating passage at IDD. Passage will provide connectivity to potential upstream spawning areas on the Yellowstone River, thereby increasing the likelihood of recruitment for this endangered species.

  20. Novel Study Guides for Biochemistry Meaningful Learning in Biology: a Design-Based Research

    Directory of Open Access Journals (Sweden)

    Costa, C ; Galembeck, E. Costa, C ; Galembeck, E.

    2017-07-01

    Full Text Available One of the difficulties for biochemistry learning is the persistence of traditional teaching methods, based on transmission and memorization of abstract and detailed information, usually in a decontextualized way. Such scenario results in surface learning and content reproduction. In order to address these problems, three interventions in a discipline (Metabolism for Biology majors were applied, in the form of innovative teaching tools (study guides. OBJECTIVES: The main goal is to evaluate the impact of these interventions on interest, motivation, and learning of the metabolic pathways. MATERIALS AND METHODS: We describe the development, application, and evaluation of two study guides – one created from a problem used as a contextual connection for glycogen metabolism study and another embedding an integrative view based on glutamate metabolism. Both materials were guided by broad themes like evolution, metabolic adaptation, and comparative biochemistry. The development of the study guides combined submicroscopic (molecular and macroscopic (body, environment levels, aiming to motivate reading and discussion. A design-based research with cycles of application and assessment was carried out, by means of classroom observation, grade analysis in written exams, and students’ interviews. RESULTS AND DISCUSSION: In general, based on in-class student feedback to professors and to the researcher in the interviews, the study guides arouse curiosity and fostered peer discussion. Final average grades indicate a good global performance in all proposed activities. Whole data from study guides’ application in classroom evidenced their impact on interest, motivation, and learning. The strategy of developing problem or integrative situation linking molecular (micro and contextual (macro levels were helpful to foster critical thinking and to value topics of scientific literacy. CONCLUSIONS: Analysis and interpretation of the results point to benefits for

  1. Designing with the mind in mind simple guide to understanding user interface design guidelines

    CERN Document Server

    Johnson, Jeff

    2014-01-01

    In this completely updated and revised edition of Designing with the Mind in Mind, Jeff Johnson provides you with just enough background in perceptual and cognitive psychology that user interface (UI) design guidelines make intuitive sense rather than being just a list or rules to follow. Early UI practitioners were trained in cognitive psychology, and developed UI design rules based on it. But as the field has evolved since the first edition of this book, designers enter the field from many disciplines. Practitioners today have enough experience in UI design that they have been exposed to

  2. State criminal justice telecommunications (STACOM). Volume 4: Network design software user's guide

    Science.gov (United States)

    Lee, J. J.

    1977-01-01

    A user's guide to the network design program is presented. The program is written in FORTRAN V and implemented on a UNIVAC 1108 computer under the EXEC-8 operating system which enables the user to construct least-cost network topologies for criminal justice digital telecommunications networks. A complete description of program features, inputs, processing logic, and outputs is presented, and a sample run and a program listing are included.

  3. Information structure design for databases a practical guide to data modelling

    CERN Document Server

    Mortimer, Andrew J

    2014-01-01

    Computer Weekly Professional Series: Information Structure Design for Databases: A Practical Guide to Data modeling focuses on practical data modeling covering business and information systems. The publication first offers information on data and information, business analysis, and entity relationship model basics. Discussions cover degree of relationship symbols, relationship rules, membership markers, types of information systems, data driven systems, cost and value of information, importance of data modeling, and quality of information. The book then takes a look at entity relationship mode

  4. Real-time solar magnetograph operation system software design and user's guide

    Science.gov (United States)

    Wang, C.

    1984-01-01

    The Real Time Solar Magnetograph (RTSM) Operation system software design on PDP11/23+ is presented along with the User's Guide. The RTSM operation software is for real time instrumentation control, data collection and data management. The data is used for vector analysis, plotting or graphics display. The processed data is then easily compared with solar data from other sources, such as the Solar Maximum Mission (SMM).

  5. Annual survival estimation of migratory songbirds confounded by incomplete breeding site-fidelity: study designs that may help

    Directory of Open Access Journals (Sweden)

    Marshall, M. R.

    2004-06-01

    Full Text Available Many species of bird exhibit varying degrees of site–fidelity to the previous year’s territory or breeding area, a phenomenon we refer to as incomplete breeding site–fidelity. If the territory they occupy is located beyond the bounds of the study area or search area (i.e., they have emigrated from the study area, the bird will go undetected and is therefore indistinguishable from dead individuals in capture–mark–recapture studies. Differential emigration rates confound inferences regarding differences in survival between sexes and among species if apparent survival rates are used as estimates of true survival. Moreover, the bias introduced by using apparent survival rates for true survival rates can have profound effects on the predictions of population persistence through time, source/sink dynamics, and other aspects of life–history theory. We investigated four study design and analysis approaches that result in apparent survival estimates that are closer to true survival estimates. Our motivation for this research stemmed from a multi–year capture–recapture study of Prothonotary Warblers (Protonotaria citrea on multiple study plots within a larger landscape of suitable breeding habitat where substantial inter–annual movements of marked individuals among neighboring study plots was documented. We wished to quantify the effects of this type of movement on annual survival estimation. The first two study designs we investigated involved marking birds in a core area and resighting them in the core as well as an area surrounding the core. For the first of these two designs, we demonstrated that as the resighting area surrounding the core gets progressively larger, and more “emigrants” are resighted, apparent survival estimates begin to approximate true survival rates (bias < 0.01. However, given observed inter–annual movements of birds, it is likely to be logistically impractical to resight birds on sufficiently large

  6. Detailed design of neutron guide tubes at the upgraded JRR-3, (1)

    International Nuclear Information System (INIS)

    Harami, Taikan; Umemura, Mutsumi; Ebisawa, Tohru.

    1985-07-01

    JRR-3, currently a heavy water moderated and cooled 10 MW reactor, is to be upgraded to a light water moderated and cooled, heavy water reflected 20 MW reactor. Two guide tubes for thermal neutron and three for cold will be installed in the reactor to transport thermal and cold neutrons from the reactor hall to the experiment hall. This describes the neutron guide tube transmission analysis program, NEUGT, which was developed to assess the design of the neutron guide tubes. The input data plotting program, PLOPINE and the output data plotting program, NEUPLOT are presented in the appendix. The NEUGT program not only calculates a neutron transmission and neutron spectra, assuming the Maxwellian spectra at the entrance of a guide tube, but also analyses the effect of abutment errors. This reports the description and the input data manual of the program in the text. Examples of analysis are given in the appendixes. The program is written in the FORTRAN 77 language for FACOM 380. (author)

  7. INCOMMANDS TDP: Human Factors Design and Evaluation Guide (PDT INCOMMANDS: Guide de Conception et d’Evaluation des Facteurs Humains)

    Science.gov (United States)

    2009-12-01

    Human-Computer Interface (AHCI) Style Guide, (Report No. 64201-97U/61223), Veridian, Veda Operations, Dayton Ohio. [13] CSFAB Osga, G. and Kellmeyer, D...Interface (AHCI) Style Guide, (Report No. 64201-97U/61223), Veridian, Veda Operations, Dayton Ohio. [14] Osga, G. and Kellmeyer, D. (2000), Combat

  8. The INCA trial (Impact of NOD2 genotype-guided antibiotic prevention on survival in patients with liver Cirrhosis and Ascites): study protocol for a randomized controlled trial.

    Science.gov (United States)

    Casper, Markus; Mengel, Martin; Fuhrmann, Christine; Herrmann, Eva; Appenrodt, Beate; Schiedermaier, Peter; Reichert, Matthias; Bruns, Tony; Engelmann, Cornelius; Grünhage, Frank; Lammert, Frank

    2015-03-08

    Patients with liver cirrhosis have a highly elevated risk of developing bacterial infections that significantly decrease survival rates. One of the most relevant infections is spontaneous bacterial peritonitis (SBP). Recently, NOD2 germline variants were found to be potential predictors of the development of infectious complications and mortality in patients with cirrhosis. The aim of the INCA (Impact of NOD2 genotype-guided antibiotic prevention on survival in patients with liver Cirrhosis and Ascites) trial is to investigate whether survival of this genetically defined high-risk group of patients with cirrhosis defined by the presence of NOD2 variants is improved by primary antibiotic prophylaxis of SBP. The INCA trial is a double-blind, placebo-controlled clinical trial with two parallel treatment arms (arm 1: norfloxacin 400 mg once daily; arm 2: placebo once daily; 12-month treatment and observational period). Balanced randomization of 186 eligible patients with stratification for the protein content of the ascites (INCA trial is first in the field of hepatology aimed at rapidly transferring and validating information on individual genetic risk into clinical decision algorithms. German Clinical Trials Register DRKS00005616 . Registered 22 January 2014. EU Clinical Trials Register EudraCT 2013-001626-26 . Registered 26 January 2015.

  9. Comparative study of LDR (Manchester system) and HDR image-guided conformal brachytherapy of cervical cancer: patterns of failure, late complications, and survival.

    Science.gov (United States)

    Narayan, Kailash; van Dyk, Sylvia; Bernshaw, David; Rajasooriyar, Chrishanthi; Kondalsamy-Chennakesavan, Srinivas

    2009-08-01

    To compare patterns of failure, late toxicities, and survival in locally advanced cervical cancer patients treated by either low-dose-rate (LDR) or conformal high-dose-rate (HDRc) brachytherapy as a part of curative radiotherapy. A retrospective comparative study of 217 advanced cervix cancer patients was conducted; 90 of these patients received LDR and 127 received HDRc brachytherapy. All patients were staged using International Federation of Gynecology and Obstetrics (FIGO) rules, had pretreatment magnetic resonance imaging (MRI), and were treated with concurrent cisplatin chemoradiotherapy. Both groups matched for FIGO stage, MRI tumor volume, and uterine invasion status. Local and pelvic failures were similar 12-13% and 14% both in both groups. Abdominal and systemic failures in LDR group were 21% and 24%, whereas corresponding failures in HDRc group were 20% and 24%. Sixty-eight percent (87/127) of patients treated by HDRc remained asymptomatic, whereas 42% (38/90) of patients were asymptomatic from the bowel and bladder symptoms after treatment with LDR. The 5-year OS rate was 60% (SE = 4%). The 5-year failure-free survival rate was 55% (SE = 3%). There was no significant difference between the groups. Image-guided HDRc planning led to a large decrease in late radiation effects in patients treated by HDRc. Patterns of failure and survival were similar in patients treated either by LDR or HDRc.

  10. Comparative Study of LDR (Manchester System) and HDR Image-guided Conformal Brachytherapy of Cervical Cancer: Patterns of Failure, Late Complications, and Survival

    International Nuclear Information System (INIS)

    Narayan, Kailash; Dyk, Sylvia van; Bernshaw, David; Rajasooriyar, Chrishanthi; Kondalsamy-Chennakesavan, Srinivas

    2009-01-01

    Purpose: To compare patterns of failure, late toxicities, and survival in locally advanced cervical cancer patients treated by either low-dose-rate (LDR) or conformal high-dose-rate (HDRc) brachytherapy as a part of curative radiotherapy. Materials and Methods: A retrospective comparative study of 217 advanced cervix cancer patients was conducted; 90 of these patients received LDR and 127 received HDRc brachytherapy. All patients were staged using International Federation of Gynecology and Obstetrics (FIGO) rules, had pretreatment magnetic resonance imaging (MRI), and were treated with concurrent cisplatin chemoradiotherapy. Both groups matched for FIGO stage, MRI tumor volume, and uterine invasion status. Results: Local and pelvic failures were similar 12-13% and 14% both in both groups. Abdominal and systemic failures in LDR group were 21% and 24%, whereas corresponding failures in HDRc group were 20% and 24%. Sixty-eight percent (87/127) of patients treated by HDRc remained asymptomatic, whereas 42% (38/90) of patients were asymptomatic from the bowel and bladder symptoms after treatment with LDR. The 5-year OS rate was 60% (SE = 4%). The 5-year failure-free survival rate was 55% (SE = 3%). There was no significant difference between the groups. Conclusions: Image-guided HDRc planning led to a large decrease in late radiation effects in patients treated by HDRc. Patterns of failure and survival were similar in patients treated either by LDR or HDRc.

  11. AbDesign: An algorithm for combinatorial backbone design guided by natural conformations and sequences.

    Science.gov (United States)

    Lapidoth, Gideon D; Baran, Dror; Pszolla, Gabriele M; Norn, Christoffer; Alon, Assaf; Tyka, Michael D; Fleishman, Sarel J

    2015-08-01

    Computational design of protein function has made substantial progress, generating new enzymes, binders, inhibitors, and nanomaterials not previously seen in nature. However, the ability to design new protein backbones for function--essential to exert control over all polypeptide degrees of freedom--remains a critical challenge. Most previous attempts to design new backbones computed the mainchain from scratch. Here, instead, we describe a combinatorial backbone and sequence optimization algorithm called AbDesign, which leverages the large number of sequences and experimentally determined molecular structures of antibodies to construct new antibody models, dock them against target surfaces and optimize their sequence and backbone conformation for high stability and binding affinity. We used the algorithm to produce antibody designs that target the same molecular surfaces as nine natural, high-affinity antibodies; in five cases interface sequence identity is above 30%, and in four of those the backbone conformation at the core of the antibody binding surface is within 1 Å root-mean square deviation from the natural antibodies. Designs recapitulate polar interaction networks observed in natural complexes, and amino acid sidechain rigidity at the designed binding surface, which is likely important for affinity and specificity, is high compared to previous design studies. In designed anti-lysozyme antibodies, complementarity-determining regions (CDRs) at the periphery of the interface, such as L1 and H2, show greater backbone conformation diversity than the CDRs at the core of the interface, and increase the binding surface area compared to the natural antibody, potentially enhancing affinity and specificity. © 2015 Wiley Periodicals, Inc.

  12. Designing with the mind in mind simple guide to understanding user interface design rules

    CERN Document Server

    Johnson, Jeff

    2010-01-01

    "Take fundamental principles of psychology. Illustrate. Combine with Fundamental Principles of Design. Stir gently until fully blended.  Read daily until finished. Caution: The mixture is addictive."-- Don Norman, Nielsen Norman group, Author of Design of Future Things."This book is a primer to understand the why of the larger human action principles at work-a sort of cognitive science for designers in a hurry. Above all, this is a book of profound insight into the human mind for practical people who want to get something done."-- Stuart Card, Senior Research Fellow and the manager of the

  13. Breaking-Cas—interactive design of guide RNAs for CRISPR-Cas experiments for ENSEMBL genomes

    Science.gov (United States)

    Oliveros, Juan C.; Franch, Mònica; Tabas-Madrid, Daniel; San-León, David; Montoliu, Lluis; Cubas, Pilar; Pazos, Florencio

    2016-01-01

    The CRISPR/Cas technology is enabling targeted genome editing in multiple organisms with unprecedented accuracy and specificity by using RNA-guided nucleases. A critical point when planning a CRISPR/Cas experiment is the design of the guide RNA (gRNA), which directs the nuclease and associated machinery to the desired genomic location. This gRNA has to fulfil the requirements of the nuclease and lack homology with other genome sites that could lead to off-target effects. Here we introduce the Breaking-Cas system for the design of gRNAs for CRISPR/Cas experiments, including those based in the Cas9 nuclease as well as others recently introduced. The server has unique features not available in other tools, including the possibility of using all eukaryotic genomes available in ENSEMBL (currently around 700), placing variable PAM sequences at 5′ or 3′ and setting the guide RNA length and the scores per nucleotides. It can be freely accessed at: http://bioinfogp.cnb.csic.es/tools/breakingcas, and the code is available upon request. PMID:27166368

  14. Design and optimization of surface profilometer based on coplanar guide rail

    Science.gov (United States)

    Chen, Shuai; Dai, Yifan; Hu, Hao; Tie, Guipeng

    2017-10-01

    In order to implement the sub-micron precision measurement, a surface profilometer which based on the coplanar guide rail is designed. This profilometer adopts the open type air floating load and is driven by the magnetic force. As to achieve sub-micron accuracy, the flatness of granite guide working face and aerodynamic block are both processed to the micron level based on the homogenization of air flotation film theory. Permanent magnet which could reduce the influence of the driving disturbance to the measurement accuracy is used as the driving part. In this paper, the bearing capacity and the air floating stiffness of air floating block are both simulated and analyzed as to optimize the design parameters firstly. The layout and magnetic force of the magnet are also simulated. According to the simulation results, type selection and the position arrangement of the magnets are then confirmed. The test results on the experimental platform show that the surface profilometer based on coplanar guide rail possess the basis for realizing the submicron precision measurement.

  15. Design and use of guided mode resonance filters for refractive index sensing

    DEFF Research Database (Denmark)

    Hermannsson, Pétur Gordon

    This Ph.D. thesis is concerned with the design and use of guided mode resonance filters (GMRF) for applications in refractive index sensing. GMRFs are optical nanostructures capable of efficiently and resonantly reflecting a narrow wavelength interval of incident broad band light. They combine...... to changes in refractive index that occur within the region overlapped by the quasi guided mode, and GMRFs are thus well suited for optical sensing and tunable filter applications. They produce a polarization dependent response and can be optically characterized in both reflection and transmission......, a lift-off process, and reactive ion etching. After an introduction to the history and principles of GMRFs, the thesis describes the state-of-the-art of relevant research in the field, covers the necessary theoretical background required to understand their operation, and discusses the fabrication...

  16. Safety Software Guide Perspectives for the Design of New Nuclear Facilities (U)

    International Nuclear Information System (INIS)

    VINCENT, Andrew

    2005-01-01

    software. The discussion provided herein illustrates benefits of applying the Safety Software Guide to work activities dependent on software applications and directed toward the design of new nuclear facilities. In particular, the Guide-based systematic approach with software enables design processes to effectively proceed and reduce the likelihood of rework activities. Several application examples are provided for the new facility

  17. Reliability of computer designed surgical guides in six implant rehabilitations with two years follow-up.

    Science.gov (United States)

    Giordano, Mauro; Ausiello, Pietro; Martorelli, Massimo; Sorrentino, Roberto

    2012-09-01

    To evaluate the reliability and accuracy of computer-designed surgical guides in osseointegrated oral implant rehabilitation. Six implant rehabilitations, with a total of 17 implants, were completed with computer-designed surgical guides, performed with the master model developed by muco-compressive and muco-static impressions. In the first case, the surgical guide had exclusively mucosal support, in the second case exclusively dental support. For all six cases computer-aided surgical planning was performed by virtual analyses with 3D models obtained by dental scan DICOM data. The accuracy and stability of implant osseointegration over two years post surgery was then evaluated with clinical and radiographic examinations. Radiographic examination, performed with digital acquisitions (RVG - Radio Video graph) and parallel techniques, allowed two-dimensional feedback with a margin of linear error of 10%. Implant osseointegration was recorded for all the examined rehabilitations. During the clinical and radiographic post-surgical assessments, over the following two years, the peri-implant bone level was found to be stable and without appearance of any complications. The margin of error recorded between pre-operative positions assigned by virtual analysis and the post-surgical digital radiographic observations was as low as 0.2mm. Computer-guided implant surgery can be very effective in oral rehabilitations, providing an opportunity for the surgeon: (a) to avoid the necessity of muco-periosteal detachments and then (b) to perform minimally invasive interventions, whenever appropriate, with a flapless approach. Copyright © 2012 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  18. Video Games: A Human Factors Guide to Visual Display Design and Instructional System Design

    Science.gov (United States)

    1984-04-01

    Abstract K Electronic video games have many of the same technological and psychological characteristics that are found in military computer-based...employed as learning vehicles, the especially compelling characteristics of electronic video games have not been fully explored for possible exploitation...new electronic video games . !? Accordingly, the following experiment was designed to determine those m dimensions along which electronic

  19. Towards Clinically Optimized MRI-guided Surgical Manipulator for Minimally Invasive Prostate Percutaneous Interventions: Constructive Design*

    Science.gov (United States)

    Eslami, Sohrab; Fischer, Gregory S.; Song, Sang-Eun; Tokuda, Junichi; Hata, Nobuhiko; Tempany, Clare M.; Iordachita, Iulian

    2013-01-01

    This paper undertakes the modular design and development of a minimally invasive surgical manipulator for MRI-guided transperineal prostate interventions. Severe constraints for the MRI-compatibility to hold the minimum artifact on the image quality and dimensions restraint of the bore scanner shadow the design procedure. Regarding the constructive design, the manipulator kinematics has been optimized and the effective analytical needle workspace is developed and followed by proposing the workflow for the manual needle insertion. A study of the finite element analysis is established and utilized to improve the mechanism weaknesses under some inevitable external forces to ensure the minimum structure deformation. The procedure for attaching a sterile plastic drape on the robot manipulator is discussed. The introduced robotic manipulator herein is aimed for the clinically prostate biopsy and brachytherapy applications. PMID:24683502

  20. Design and analysis methods for fish survival experiments based on release-recapture

    National Research Council Canada - National Science Library

    Burnham, Kenneth P

    1987-01-01

    .... The application of the methods developed here is more general, however, as it includes experiments to estimate survival of fish as they pass over spillways or through bypass systems and several dams...

  1. Design of focussing and guide structures for charged particle beams using rare earth cobalt permanent magnets

    International Nuclear Information System (INIS)

    Halbach, K.

    1981-06-01

    A number of different methods can be used to describe the magnetic properties of oriented Rare Earth Cobalt (REC) material. It will be shown how these different methods of description lead to different ways to think about, and to execute, the design of magnets that are useful for focusing and guiding charged particle beams. It will also be domonstrated that in some of these magnets, the REC material is used in a somewhat unusual way, requiring magnetics properties of the material that are usually not considered to be of great practical importance

  2. Expert-guided evolutionary algorithm for layout design of complex space stations

    Science.gov (United States)

    Qian, Zhiqin; Bi, Zhuming; Cao, Qun; Ju, Weiguo; Teng, Hongfei; Zheng, Yang; Zheng, Siyu

    2017-08-01

    The layout of a space station should be designed in such a way that different equipment and instruments are placed for the station as a whole to achieve the best overall performance. The station layout design is a typical nondeterministic polynomial problem. In particular, how to manage the design complexity to achieve an acceptable solution within a reasonable timeframe poses a great challenge. In this article, a new evolutionary algorithm has been proposed to meet such a challenge. It is called as the expert-guided evolutionary algorithm with a tree-like structure decomposition (EGEA-TSD). Two innovations in EGEA-TSD are (i) to deal with the design complexity, the entire design space is divided into subspaces with a tree-like structure; it reduces the computation and facilitates experts' involvement in the solving process. (ii) A human-intervention interface is developed to allow experts' involvement in avoiding local optimums and accelerating convergence. To validate the proposed algorithm, the layout design of one-space station is formulated as a multi-disciplinary design problem, the developed algorithm is programmed and executed, and the result is compared with those from other two algorithms; it has illustrated the superior performance of the proposed EGEA-TSD.

  3. Toward Eco Product Development with Qualitative and CAE Design Process - Case Study of Flame Guiding Module

    Science.gov (United States)

    Chen, W. L.; Chao, F. L.

    2018-04-01

    Sustainable products become increasingly important for company in addressing eco-performance to satisfy global environmental regulations. Case study of flame guiding module reviewed design process and concerns related to the torch design. For enhancing flame height, the torch was embedded with an airflow guidance structure. The design process and design methodologies were investigated as an eco-design case study. Combine qualitative and CAE simulation were proposed to fulfil its main and auxiliary functions including reduction of impact during use. The design guidelines help prevent mistake arrangements, CAE helps understand combustion phenomenon. The flow field simulation enables fine tune of geometric design. Functional test and measurement are carried out to confirm the product features. On Eco-performance, we choose 5 items for evaluation the status of previous and redesign module, namely function need, low impact material, few manufacturing steps, low energy consumption, and safety. The radar diagram indicates that eco-performance of redesign module is better. Life cycle assessment calculated the carbon footprint of the manufacturing and processing stage with Eco-it. By using recycled steel in the flame module, it reduces raw material stage carbon footprint significantly.

  4. Technical procedures for template-guided surgery for mandibular reconstruction based on digital design and manufacturing.

    Science.gov (United States)

    Liu, Yun-feng; Xu, Liang-wei; Zhu, Hui-yong; Liu, Sean Shih-Yao

    2014-05-23

    The occurrence of mandibular defects caused by tumors has been continuously increasing in China in recent years. Conversely, results of the repair of mandibular defects affect the recovery of oral function and patient appearance, and the requirements for accuracy and high surgical quality must be more stringent. Digital techniques--including model reconstruction based on medical images, computer-aided design, and additive manufacturing--have been widely used in modern medicine to improve the accuracy and quality of diagnosis and surgery. However, some special software platforms and services from international companies are not always available for most of researchers and surgeons because they are expensive and time-consuming. Here, a new technical solution for guided surgery for the repair of mandibular defects is proposed, based on general popular tools in medical image processing, 3D (3 dimension) model reconstruction, digital design, and fabrication via 3D printing. First, CT (computerized tomography) images are processed to reconstruct the 3D model of the mandible and fibular bone. The defect area is then replaced by healthy contralateral bone to create the repair model. With the repair model as reference, the graft shape and cutline are designed on fibular bone, as is the guide for cutting and shaping. The physical model, fabricated via 3D printing, including surgical guide, the original model, and the repair model, can be used to preform a titanium locking plate, as well as to design and verify the surgical plan and guide. In clinics, surgeons can operate with the help of the surgical guide and preformed plate to realize the predesigned surgical plan. With sufficient communication between engineers and surgeons, an optimal surgical plan can be designed via some common software platforms but needs to be translated to the clinic. Based on customized models and tools, including three surgical guides, preformed titanium plate for fixation, and physical models of

  5. Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model

    Directory of Open Access Journals (Sweden)

    Du Y

    2017-11-01

    Full Text Available Yang Du,1,2,* Ting Sun,3,* Xiaolong Liang,4,* Yuan Li,3 Zhengyu Jin,3 Huadan Xue,3 Yihong Wan,5 Jie Tian1,2 1CAS Key Laboratory of Molecular Imaging, 2The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, 3Department of Radiology, Peking Union Medical College Hospital, 4Department of Ultrasound, Peking University Third Hospital, Beijing, China; 5Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA *These authors contributed equally to this work Abstract: An intraoperative technique to accurately identify microscopic tumor residuals could decrease the risk of positive surgical margins. Several lines of evidence support the expression and immunotherapeutic effect of PD-1 in breast cancer. Here, we sought to develop a fluorescence-labeled PD-1 probe for in vivo breast tumor imaging and image-guided surgery. The efficacy of PD-1 monoclonal antibody (PD-1 mAb as adjuvant immunotherapy after surgery was also assessed. PD-1-IRDye800CW was developed and examined for its application in tumor imaging and image-guided tumor resection in an immunocompetent 4T1 mouse tumor model. Fluorescence molecular imaging was performed to monitor probe biodistribution and intraoperative imaging. Bioluminescence imaging was performed to monitor tumor growth and evaluate postsurgical tumor residuals, recurrences, and metastases. The PD-1-IRDye800CW exhibited a specific signal at the tumor region compared with the IgG control. Furthermore, PD-1-IRDye800CW-guided surgery combined with PD-1 adjuvant immunotherapy inhibited tumor regrowth and microtumor metastases and thus improved survival rate. Our study demonstrates the feasibility of using PD-1-IRDye800CW for breast tumor imaging and image-guided tumor resection. Moreover, PD-1 mAb adjuvant immunotherapy reduces cancer recurrences and metastases emanating from tumor residuals. Keywords: PD-1, programmed cell

  6. Design of pre-optics for laser guide star wavefront sensor for the ELT

    Science.gov (United States)

    Muslimov, Eduard; Dohlen, Kjetil; Neichel, Benoit; Hugot, Emmanuel

    2017-12-01

    In the present paper, we consider the optical design of a zoom system for the active refocusing in laser guide star wavefront sensors. The system is designed according to the specifications coming from the Extremely Large Telescope (ELT)-HARMONI instrument, the first-light, integral field spectrograph for the European (E)-ELT. The system must provide a refocusing of the laser guide as a function of telescope pointing and large decentring of the incoming beam. The system considers four moving lens groups, each of them being a doublet with one aspherical surface. The advantages and shortcomings of such a solution in terms of the component displacements and complexity of the surfaces are described in detail. It is shown that the system can provide the median value of the residual wavefront error of 13.8-94.3 nm and the maximum value <206 nm, while the exit pupil distortion is 0.26-0.36% for each of the telescope pointing directions.

  7. Electron work function-a promising guiding parameter for material design.

    Science.gov (United States)

    Lu, Hao; Liu, Ziran; Yan, Xianguo; Li, Dongyang; Parent, Leo; Tian, Harry

    2016-04-14

    Using nickel added X70 steel as a sample material, we demonstrate that electron work function (EWF), which largely reflects the electron behavior of materials, could be used as a guide parameter for material modification or design. Adding Ni having a higher electron work function to X70 steel brings more "free" electrons to the steel, leading to increased overall work function, accompanied with enhanced e(-)-nuclei interactions or higher atomic bond strength. Young's modulus and hardness increase correspondingly. However, the free electron density and work function decrease as the Ni content is continuously increased, accompanied with the formation of a second phase, FeNi3, which is softer with a lower work function. The decrease in the overall work function corresponds to deterioration of the mechanical strength of the steel. It is expected that EWF, a simple but fundamental parameter, may lead to new methodologies or supplementary approaches for metallic materials design or tailoring on a feasible electronic base.

  8. Procedure guide of design, construction of prototypes, calibration and sure operation of nucleonic control systems

    International Nuclear Information System (INIS)

    Banados Perez, H.; Griffith Martinez, J.; Desdin Garcia, L.F.; Rodriguez Cardona, R.L.; Molina, G.; Sebastian Calvo, C.

    1999-01-01

    This Guide was elaborated in the mark of the project RLA/8/024 ARCAL XLII 'Industrial Applications of the Tracer Technology and Nucleonic Control Systems'. Its objective is to establish the approaches for the design, the construction, the selection and the procedures for the sure operation of the Nucleonic Control Systems (NCS) in the industry. The NCS is used to control processes to high speeds, materials with extreme conditions or with noxious chemical properties, susceptible materials of being damaged by contact and packed products. In this document is defined the scope of the procedure. The SCN are classified according to: type of radiations, the mobility of the components, the degree of the beams collimation; and in function of the security. The design and construction criteria of the nuclear meters and of the systems of control nucleonic are exposed

  9. Neural Network Control-Based Drive Design of Servomotor and Its Application to Automatic Guided Vehicle

    Directory of Open Access Journals (Sweden)

    Ming-Shyan Wang

    2015-01-01

    Full Text Available An automatic guided vehicle (AGV is extensively used for productions in a flexible manufacture system with high efficiency and high flexibility. A servomotor-based AGV is designed and implemented in this paper. In order to steer the AGV to go along a predefined path with corner or arc, the conventional proportional-integral-derivative (PID control is used in the system. However, it is difficult to tune PID gains at various conditions. As a result, the neural network (NN control is considered to assist the PID control for gain tuning. The experimental results are first provided to verify the correctness of the neural network plus PID control for 400 W-motor control system. Secondly, the AGV includes two sets of the designed motor systems and CAN BUS transmission so that it can move along the straight line and curve paths shown in the taped videos.

  10. External Events Excluding Earthquakes in the Design of Nuclear Power Plants. Safety Guide

    International Nuclear Information System (INIS)

    2008-01-01

    This Safety Guide provides recommendations and guidance on design for the protection of nuclear power plants from the effects of external events (excluding earthquakes), i.e. events that originate either off the site or within the boundaries of the site but from sources that are not directly involved in the operational states of the nuclear power plant units. In addition, it provides recommendations on engineering related matters in order to comply with the safety objectives and requirements established in the IAEA Safety Requirements publication, Safety of Nuclear Power Plants: Design. It is also applicable to the design and safety assessment of items important to the safety of land based stationary nuclear power plants with water cooled reactors. Contents: 1. Introduction; 2. Application of safety criteria to the design; 3. Design basis for external events; 4. Aircraft crash; 5. External fire; 6. Explosions; 7. Asphyxiant and toxic gases; 8. Corrosive and radioactive gases and liquids; 9. Electromagnetic interference; 10. Floods; 11. Extreme winds; 12. Extreme meteorological conditions; 13. Biological phenomena; 14. Volcanism; 15. Collisions of floating bodies with water intakes and UHS components; Annex I: Aircraft crashes; Annex II: Detonation and deflagration; Annex III: Toxicity limits.

  11. Effects of temperature on development, survival and reproduction of insects: Experimental design, data analysis and modeling

    Science.gov (United States)

    Jacques Regniere; James Powell; Barbara Bentz; Vincent Nealis

    2012-01-01

    The developmental response of insects to temperature is important in understanding the ecology of insect life histories. Temperature-dependent phenology models permit examination of the impacts of temperature on the geographical distributions, population dynamics and management of insects. The measurement of insect developmental, survival and reproductive responses to...

  12. Design and experimental validation of the inlet guide vane system of a mini hydraulic bulb-turbine

    Energy Technology Data Exchange (ETDEWEB)

    Ferro, L.M.C. [Department of Mechanical Engineering, Escola Superior de Tecnologia de Setubal, Polytechnic Institute of Setubal, Campus do IPS, Estefanilha, 2910-761 Setubal (Portugal); IDMEC, Instituto Superior Tecnico, Technical University of Lisbon, Av. Rovisco Pais,1049-001 Lisboa (Portugal); Gato, L.M.C.; Falcao, A.F.O. [IDMEC, Instituto Superior Tecnico, Technical University of Lisbon, Av. Rovisco Pais,1049-001 Lisboa (Portugal)

    2010-09-15

    The paper presents a fast design method for the inlet guide vanes of low-cost mini hydraulic bulb turbines. The guide vanes are positioned between two conical surfaces with a common vertex and have constant thickness distribution, except close to the leading and the trailing edges. The conical-walled inlet guide vane row is designed using a quasi-three-dimensional calculation method, by prescribing the angular-momentum distribution along the span at the outlet section of the guide vanes. The meridional through-flow is computed by a streamline curvature method and the blade-to-blade flow by a singularity surface method. The stagger angle and the vane camber are computed to fulfil the required design circulation and zero-incidence flow at the leading edge. The final vane shape is a single-curvature surface with straight leading and trailing edges. To validate the design method, a conical-walled inlet guide vane row nozzle-model with six fixed vanes was designed, manufactured and tested in an airflow rig. Traversing measurements along the circumferential and radial directions were made with a five-hole probe. The experimental results are compared with the prescribed design conditions and with numerical results from the three-dimensional inviscid and viscous flow computed with the FLUENT code. (author)

  13. Defining SOD1 ALS natural history to guide therapeutic clinical trial design.

    Science.gov (United States)

    Bali, Taha; Self, Wade; Liu, Jingxia; Siddique, Teepu; Wang, Leo H; Bird, Thomas D; Ratti, Elena; Atassi, Nazem; Boylan, Kevin B; Glass, Jonathan D; Maragakis, Nicholas J; Caress, James B; McCluskey, Leo F; Appel, Stanley H; Wymer, James P; Gibson, Summer; Zinman, Lorne; Mozaffar, Tahseen; Callaghan, Brian; McVey, April L; Jockel-Balsarotti, Jennifer; Allred, Peggy; Fisher, Elena R; Lopate, Glenn; Pestronk, Alan; Cudkowicz, Merit E; Miller, Timothy M

    2017-02-01

    Understanding the natural history of familial amyotrophic lateral sclerosis (ALS) caused by SOD1 mutations (ALS SOD1 ) will provide key information for optimising clinical trials in this patient population. To establish an updated natural history of ALS SOD1 . Retrospective cohort study from 15 medical centres in North America evaluated records from 175 patients with ALS with genetically confirmed SOD1 mutations, cared for after the year 2000. Age of onset, survival, ALS Functional Rating Scale (ALS-FRS) scores and respiratory function were analysed. Patients with the A4V (Ala-Val) SOD1 mutation (SOD1 A4V ), the largest mutation population in North America with an aggressive disease progression, were distinguished from other SOD1 mutation patients (SOD1 non-A4V ) for analysis. Mean age of disease onset was 49.7±12.3 years (mean±SD) for all SOD1 patients, with no statistical significance between SOD1 A4V and SOD1 non-A4V (p=0.72, Kruskal-Wallis). Total SOD1 patient median survival was 2.7 years. Mean disease duration for all SOD1 was 4.6±6.0 and 1.4±0.7 years for SOD1 A4V . SOD1 A4V survival probability (median survival 1.2 years) was significantly decreased compared with SOD1 non-A4V (median survival 6.8 years; p<0.0001, log-rank). A statistically significant increase in ALS-FRS decline in SOD1 A4V compared with SOD1 non-A4V participants (p=0.02) was observed, as well as a statistically significant increase in ALS-forced vital capacity decline in SOD1 A4V compared with SOD1 non-A4V (p=0.02). SOD1 A4V is an aggressive, but relatively homogeneous form of ALS. These SOD1-specific ALS natural history data will be important for the design and implementation of clinical trials in the ALS SOD1 patient population. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  14. Radiation protection aspects in the design of nuclear power plants. Safety guide

    International Nuclear Information System (INIS)

    2008-01-01

    . The IAEA takes seriously the enduring challenge for users and regulators everywhere: that of ensuring a high level of safety in the use of nuclear materials and radiation sources around the world. Their continuing utilization for the benefit of humankind must be managed in a safe manner, and the IAEA safety standards are designed to facilitate the achievement of that goal. This Safety Guide has been prepared as a part of the IAEA programme on safety standards for nuclear power plants. It includes recommendations on how to satisfy the requirements established in the Safety Requirements publication on the Safety of Nuclear Power Plants: Design. It addresses the provisions that should be made in the design of nuclear power plants in order to protect site personnel, the public and the environment against radiological hazards for operational states, decommissioning and accident conditions. The recommendations on radiation protection provided in this Safety Guide are consistent with the International Basic Safety Standards for Protection against Ionizing Radiation and for the Safety of Radiation Sources (BSS), which were jointly sponsored by the Food and Agriculture Organization of the United Nations (FAO), the IAEA, the International Labour Organisation (ILO), the OECD Nuclear Energy Agency (OECD/NEA), the Pan American Health Organization (PAHO) and the World Health Organization (WHO). This Safety Guide supersedes Safety Series No. 50-SG-D9, Design Aspects of Radiation Protection for Nuclear Power Plants, published in 1985. Effective radiation protection is a combination of good design, high quality construction and proper operation. Procedures that address the radiation protection aspects of operation are covered in the Safety Guide on Radiation Protection and Radioactive Waste Management in the operation of Nuclear Power Plants

  15. Radiation protection aspects of design for nuclear power plants. Safety guide

    International Nuclear Information System (INIS)

    2005-01-01

    . The IAEA takes seriously the enduring challenge for users and regulators everywhere: that of ensuring a high level of safety in the use of nuclear materials and radiation sources around the world. Their continuing utilization for the benefit of humankind must be managed in a safe manner, and the IAEA safety standards are designed to facilitate the achievement of that goal. This Safety Guide has been prepared as a part of the IAEA programme on safety standards for nuclear power plants. It includes recommendations on how to satisfy the requirements established in the Safety Requirements publication on the Safety of Nuclear Power Plants: Design. It addresses the provisions that should be made in the design of nuclear power plants in order to protect site personnel, the public and the environment against radiological hazards for operational states, decommissioning and accident conditions. The recommendations on radiation protection provided in this Safety Guide are consistent with the International Basic Safety Standards for Protection against Ionizing Radiation and for the Safety of Radiation Sources (BSS), which were jointly sponsored by the Food and Agriculture Organization of the United Nations (FAO), the IAEA, the International Labour Organisation (ILO), the OECD Nuclear Energy Agency (OECD/NEA), the Pan American Health Organization (PAHO) and the World Health Organization (WHO). This Safety Guide supersedes Safety Series No. 50-SG-D9, Design Aspects of Radiation Protection for Nuclear Power Plants, published in 1985. Effective radiation protection is a combination of good design, high quality construction and proper operation. Procedures that address the radiation protection aspects of operation are covered in the Safety Guide on Radiation Protection and Radioactive Waste Management in the operation of Nuclear Power Plants

  16. A Guide to Axial-Flow Turbine Off-Design Computer Program AXOD2

    Science.gov (United States)

    Chen, Shu-Cheng S.

    2014-01-01

    A Users Guide for the axial flow turbine off-design computer program AXOD2 is composed in this paper. This Users Guide is supplementary to the original Users Manual of AXOD. Three notable contributions of AXOD2 to its predecessor AXOD, both in the context of the Guide or in the functionality of the code, are described and discussed in length. These are: 1) a rational representation of the mathematical principles applied, with concise descriptions of the formulas implemented in the actual coding. Their physical implications are addressed; 2) the creation and documentation of an Addendum Listing of input namelist-parameters unique to AXOD2, that differ from or are in addition to the original input-namelists given in the Manual of AXOD. Their usages are discussed; and 3) the institution of proper stoppages of the code execution, encoding termination messaging and error messages of the execution to AXOD2. These measures are to safe-guard the integrity of the code execution, such that a failure mode encountered during a case-study would not plunge the code execution into indefinite loop, or cause a blow-out of the program execution. Details on these are discussed and illustrated in this paper. Moreover, this computer program has since been reconstructed substantially. Standard FORTRAN Langue was instituted, and the code was formatted in Double Precision (REAL*8). As the result, the code is now suited for use in a local Desktop Computer Environment, is perfectly portable to any Operating System, and can be executed by any FORTRAN compiler equivalent to a FORTRAN 9095 compiler. AXOD2 will be available through NASA Glenn Research Center (GRC) Software Repository.

  17. Masked Visual Analysis: Minimizing Type I Error in Visually Guided Single-Case Design for Communication Disorders

    Science.gov (United States)

    Byun, Tara McAllister; Hitchcock, Elaine R.; Ferron, John

    2017-01-01

    Purpose: Single-case experimental designs are widely used to study interventions for communication disorders. Traditionally, single-case experiments follow a response-guided approach, where design decisions during the study are based on participants' observed patterns of behavior. However, this approach has been criticized for its high rate of…

  18. 77 FR 64564 - Implementation of Regulatory Guide 1.221 on Design-Basis Hurricane and Hurricane Missiles

    Science.gov (United States)

    2012-10-22

    ...-Basis Hurricane and Hurricane Missiles AGENCY: Nuclear Regulatory Commission. ACTION: Proposed interim...-ISG-024, ``Implementation of Regulatory Guide 1.221 on Design-Basis Hurricane and Hurricane Missiles....221, ``Design-Basis Hurricane and Hurricane Missiles for Nuclear Power Plants.'' DATES: Submit...

  19. Design of a high efficiency relativistic backward wave oscillator with low guiding magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Li, Xiaoze; Song, Wei; Tan, Weibing; Zhang, Ligang; Su, Jiancang; Zhu, Xiaoxin; Hu, Xianggang; Shen, Zhiyuan; Liang, Xu; Ning, Qi [Science and Technology on High Power Microwave Laboratory, Northwest Institute of Nuclear Technology, Xi' an 710024 (China)

    2016-07-15

    A high efficiency relativistic backward wave oscillator working at a low guiding magnetic field is designed and simulated. A trapezoidal resonant reflector is used to reduce the modulation field in the resonant reflector to avoid overmodulation of the electron beam which will lead to a large momentum spread and then low conversion efficiency. The envelope of the inner radius of the slow wave structure (SWS) increases stepwise to keep conformal to the trajectory of the electron beam which will alleviate the bombardment of the electron on the surface of the SWS. The length of period of the SWS is reduced gradually to make a better match between phase velocity and electron beam, which decelerates continually and improves the RF current distribution. Meanwhile the modulation field is reduced by the introduction of nonuniform SWS also. The particle in cell simulation results reveal that a microwave with a power of 1.8 GW and a frequency of 14.7 GHz is generated with an efficiency of 47% when the diode voltage is 620 kV, the beam current 6.1 kA, and the guiding magnetic field 0.95 T.

  20. Changes in the design, fabrication and setting of guide tube support pins in alloy X750

    International Nuclear Information System (INIS)

    Benhamou, C.; Chambrin, J.L.; Todeschini, P.; Champredonde, J.; Lemaire, E.

    2004-01-01

    As a consequence of a problem of stress corrosion cracking (SCC) encountered on guide tube support pins (GTSP) of first generation (1982) and of second generation (1987), EDF and Framatome decided in mars 1988 to launch an important program involving a complete overhaul of the design, the material used, the fabrication and the setting in reactor of GTSP. This program has led to the implementation in 900 MWe and 1300 MWe PWR of a new tube guide support pin called NG89. This implementation began in 1989, now 15 years later, 40% of the operating GTSP in 900 MWe and 1300 MWe PWR are of NG89 type, the oldest ones cumulate 105000 hours in service without negative feedback experience. The main features of the NG89 is: - to be made from an alloy X-750 containing boron (from 25 to 45 ppm) - to have a SCC threshold set at 720 MPa - to be machined from metal bars completely treated, - to have a rolling of the fillets, and - to undergo a shot blasting on the zones of the surface the most acted upon. (A.C.)

  1. Crystal-Structure-Guided Design of Self-Assembling RNA Nanotriangles.

    Science.gov (United States)

    Boerneke, Mark A; Dibrov, Sergey M; Hermann, Thomas

    2016-03-14

    RNA nanotechnology uses RNA structural motifs to build nanosized architectures that assemble through selective base-pair interactions. Herein, we report the crystal-structure-guided design of highly stable RNA nanotriangles that self-assemble cooperatively from short oligonucleotides. The crystal structure of an 81 nucleotide nanotriangle determined at 2.6 Å resolution reveals the so-far smallest circularly closed nanoobject made entirely of double-stranded RNA. The assembly of the nanotriangle architecture involved RNA corner motifs that were derived from ligand-responsive RNA switches, which offer the opportunity to control self-assembly and dissociation. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Guide to shielding calculations for the design of fluoroscopic laboratory at 503 workshop AVN base Rawalpindi

    International Nuclear Information System (INIS)

    Din, J.U.; Ahmad, M.; Ashraf, M.M.; Khan, A.R.; Khan, A.A.

    1986-11-01

    Non-destructive testing plays an important role in assessing the quality of materials. Various methods are used for this purpose. Radiography by X-rays and gamma-rays is one of the NDT methods used. There are number of mathematical formulae used to estimate the required shielding for an X-ray tube operating at maximum rated voltage or a gamma radiation source having fixed energies. This report covers the shielding requirements for a 150 KV constant potential X-ray unit operating at maximum rated voltage. In addition, the report is a guide for the design of shielded enclosure required for X-rays machines in general. (orig./A.B.)

  3. Development of the Advanced Energy Design Guide for K-12 Schools -- 50% Energy Savings

    Energy Technology Data Exchange (ETDEWEB)

    Bonnema, E.; Leach, M.; Pless, S.; Torcellini, P.

    2013-02-01

    This Technical Support Document (TSD) describes the process and methodology for the development of the Advanced Energy Design Guide for K-12 School Buildings: Achieving 50% Energy Savings Toward a Net Zero Energy Building (AEDG-K12) (ASHRAE et al. 2011a). The AEDG-K12 provides recommendations for achieving 50% whole-building energy savings in K-12 schools over levels achieved by following ANSI/ASHRAE/IESNA Standard 90.1-2004, Energy Standard for Buildings Except Low-Rise Residential Buildings (Standard 90.1-2004) (ASHRAE 2004b). The AEDG-K12 was developed in collaboration with the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE), the American Institute of Architects (AIA), the Illuminating Engineering Society of North America (IES), the U.S. Green Building Council (USGBC), and the U.S. Department of Energy (DOE).

  4. The importance of the instructional guide in the design of virtual learning environments

    Directory of Open Access Journals (Sweden)

    Aida Mercedes Gomez-Suarez

    2017-07-01

    Full Text Available The appropriation of information and communication technologies (ICTs in the processes of teaching and learning is one of the main challenges of educational institutions and teachers in the current society of knowledge, as responsible for a use Rational and meaningful use of its digital educational resources (RED. This involves developing competencies in the implementation of ICT in the classroom to enrich the learning environments. This article presents a reflection on the instructional guide as a didactic tool in the elaboration of RED that facilitates the design of these resources to support the activities of the classroom in these processes. This reflection is the result of a research on the subject carried out in a context of university teaching

  5. Technical Support Document: Development of the Advanced Energy Design Guide for Large Hospitals - 50% Energy Savings

    Energy Technology Data Exchange (ETDEWEB)

    Bonnema, E.; Leach, M.; Pless, S.

    2013-06-01

    This Technical Support Document describes the process and methodology for the development of the Advanced Energy Design Guide for Large Hospitals: Achieving 50% Energy Savings Toward a Net Zero Energy Building (AEDG-LH) ASHRAE et al. (2011b). The AEDG-LH is intended to provide recommendations for achieving 50% whole-building energy savings in large hospitals over levels achieved by following Standard 90.1-2004. The AEDG-LH was created for a 'standard' mid- to large-size hospital, typically at least 100,000 ft2, but the strategies apply to all sizes and classifications of new construction hospital buildings. Its primary focus is new construction, but recommendations may be applicable to facilities undergoing total renovation, and in part to many other hospital renovation, addition, remodeling, and modernization projects (including changes to one or more systems in existing buildings).

  6. Design report on the guide box-reactivity and safety control plates for MPR reactor under normal operation conditions

    International Nuclear Information System (INIS)

    Markiewicz, M.

    1999-01-01

    The reactivity control system for the MPR reactor (Multi Purpose Reactor) is a critical component regarding safety, it must ensure a fast shut down, maintaining the reactor in subcritical condition under normal or accidental operation condition. For this purpose, this core component must be designed to maintain its operating capacity during all the residence time and under any foreseen operation condition. The mechanical design of control plates and guide boxes must comply with structural integrity, maintaining its geometric and dimensional stability within the pre-established limits to prevent interferences with other core components. For this, the heat generation effect, mechanical loads and environment and irradiation effects were evaluated during the mechanical design. The reactivity control system is composed of guide boxes, manufactured from Aluminium alloy, located between the fuel elements, and control absorber plates of Ag-In-Cd alloy hermetically enclosed by a cladding of stainless steel sliding inside de guide boxes. The upward-downward movement is transmitted by a rod from the motion device located at the reactor lower part. The design requirements, criteria and limits were established to fulfill with the normal and abnormal operation conditions. The design verifications were performed by analytical method, estimating the guide box and control plates residence time. The result of the analysis performed, shows that the design of the reactivity control system and the material selected, are appropriate to fulfill the functional requirements, with no failures attributed to the mechanical design. (author)

  7. An optimization design proposal of automated guided vehicles for mixed type transportation in hospital environments.

    Science.gov (United States)

    González, Domingo; Romero, Luis; Espinosa, María Del Mar; Domínguez, Manuel

    2017-01-01

    The aim of this paper is to present an optimization proposal in the automated guided vehicles design used in hospital logistics, as well as to analyze the impact of its implementation in a real environment. This proposal is based on the design of those elements that would allow the vehicles to deliver an extra cart by the towing method. So, the proposal intention is to improve the productivity and the performance of the current vehicles by using a transportation method of combined carts. The study has been developed following concurrent engineering premises from three different viewpoints. First, the sequence of operations has been described, and second, a proposal of design of the equipment has been undertaken. Finally, the impact of the proposal has been analyzed according to real data from the Hospital Universitario Rio Hortega in Valladolid (Spain). In this particular case, by the implementation of the analyzed proposal in the hospital a reduction of over 35% of the current time of use can be achieved. This result may allow adding new tasks to the vehicles, and according to this, both a new kind of vehicle and a specific module can be developed in order to get a better performance.

  8. An optimization design proposal of automated guided vehicles for mixed type transportation in hospital environments.

    Directory of Open Access Journals (Sweden)

    Domingo González

    Full Text Available The aim of this paper is to present an optimization proposal in the automated guided vehicles design used in hospital logistics, as well as to analyze the impact of its implementation in a real environment.This proposal is based on the design of those elements that would allow the vehicles to deliver an extra cart by the towing method. So, the proposal intention is to improve the productivity and the performance of the current vehicles by using a transportation method of combined carts.The study has been developed following concurrent engineering premises from three different viewpoints. First, the sequence of operations has been described, and second, a proposal of design of the equipment has been undertaken. Finally, the impact of the proposal has been analyzed according to real data from the Hospital Universitario Rio Hortega in Valladolid (Spain. In this particular case, by the implementation of the analyzed proposal in the hospital a reduction of over 35% of the current time of use can be achieved. This result may allow adding new tasks to the vehicles, and according to this, both a new kind of vehicle and a specific module can be developed in order to get a better performance.

  9. Software life cycle process and classification guides for KNICS digital instrumentation and control system design

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jang Soo; Son, Han Seung; Kim, Jang Yeol; Kwon, Kee Choon; Lee, Soon Seung; Kim, Doo Hwan [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2002-04-01

    Documentation should exist that shows that the qualification activities have been successfully accomplished for each life cycle activity group. In particular, the documentation should show that the system safety requirements have been adequately addressed for each life cycle activity group, that no new hazards have been introduced, and that the software requirements, design elements, and code elements that can affect safety have been identified. Because the safety of software can be assured through both the process Verification and Validation (V and V) itself and the V and V of all the intermediate and final products during the software development lifecycle, the development of KNICS Software Safety Framework (KSSF) must be established. As the first activity for establishing KSSF, we have developed this report, Software Life Cycle Process and Classification Guides for KNICS Digital I and C System. This report is organized as follows. Chapter I describes the background, definitions, and references of SLCP. Chapter II describes KNICS safety software categorization. In Chapter III, we define the requirements on software life cycle process for designing digital KNICS. Chapter III.3, that is the main section of the chapter, includes the requirements for software life cycle process planning, the requirements for software life cycle process implementation, and the requirements for software life cycle process design outputs. Finally, we have described the result of a case study on the SLCP for developing the software of ESF-CCS system that is being developed by a private company, BNF. 29 refs., 5 figs., 7 tabs. (Author)

  10. Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients

    Science.gov (United States)

    Wang, Conan K.; Northfield, Susan E.; Colless, Barbara; Chaousis, Stephanie; Hamernig, Ingrid; Lohman, Rink-Jan; Nielsen, Daniel S.; Schroeder, Christina I.; Liras, Spiros; Price, David A.; Fairlie, David P.; Craik, David J.

    2014-01-01

    Enhancing the oral bioavailability of peptide drug leads is a major challenge in drug design. As such, methods to address this challenge are highly sought after by the pharmaceutical industry. Here, we propose a strategy to identify appropriate amides for N-methylation using temperature coefficients measured by NMR to identify exposed amides in cyclic peptides. N-methylation effectively caps these amides, modifying the overall solvation properties of the peptides and making them more membrane permeable. The approach for identifying sites for N-methylation is a rapid alternative to the elucidation of 3D structures of peptide drug leads, which has been a commonly used structure-guided approach in the past. Five leucine-rich peptide scaffolds are reported with selectively designed N-methylated derivatives. In vitro membrane permeability was assessed by parallel artificial membrane permeability assay and Caco-2 assay. The most promising N-methylated peptide was then tested in vivo. Here we report a novel peptide (15), which displayed an oral bioavailability of 33% in a rat model, thus validating the design approach. We show that this approach can also be used to explain the notable increase in oral bioavailability of a somatostatin analog. PMID:25416591

  11. Designing nanomaterials to maximize performance and minimize undesirable implications guided by the Principles of Green Chemistry.

    Science.gov (United States)

    Gilbertson, Leanne M; Zimmerman, Julie B; Plata, Desiree L; Hutchison, James E; Anastas, Paul T

    2015-08-21

    The Twelve Principles of Green Chemistry were first published in 1998 and provide a framework that has been adopted not only by chemists, but also by design practitioners and decision-makers (e.g., materials scientists and regulators). The development of the Principles was initially motivated by the need to address decades of unintended environmental pollution and human health impacts from the production and use of hazardous chemicals. Yet, for over a decade now, the Principles have been applied to the synthesis and production of engineered nanomaterials (ENMs) and the products they enable. While the combined efforts of the global scientific community have led to promising advances in the field of nanotechnology, there remain significant research gaps and the opportunity to leverage the potential global economic, societal and environmental benefits of ENMs safely and sustainably. As such, this tutorial review benchmarks the successes to date and identifies critical research gaps to be considered as future opportunities for the community to address. A sustainable material design framework is proposed that emphasizes the importance of establishing structure-property-function (SPF) and structure-property-hazard (SPH) relationships to guide the rational design of ENMs. The goal is to achieve or exceed the functional performance of current materials and the technologies they enable, while minimizing inherent hazard to avoid risk to human health and the environment at all stages of the life cycle.

  12. The Effect of Femoral Cutting Guide Design Improvements for Patient-Specific Instruments

    Directory of Open Access Journals (Sweden)

    Oh-Ryong Kwon

    2015-01-01

    Full Text Available Although the application of patient-specific instruments (PSI for total knee arthroplasty (TKA increases the cost of the surgical procedure, PSI may reduce operative time and improve implant alignment, which could reduce the number of revision surgeries. We report our experience with TKA using PSI techniques in 120 patients from March to December 2014. PSI for TKA were created from data provided by computed tomography (CT scans or magnetic resonance imaging (MRI; which imaging technology is more reliable for the PSI technique remains unclear. In the first 20 patients, the accuracy of bone resection and PSI stability were compared between CT and MRI scans with presurgical results as a reference; MRI produced better results. In the second and third groups, each with 50 patients, the results of bone resection and stability were compared in MRI scans with respect to the quality of scanning due to motion artifacts and experienced know-how in PSI design, respectively. The optimized femoral cutting guide design for PSI showed the closest outcomes in bone resection and PSI stability with presurgical data. It is expected that this design could be a reasonable guideline in PSI.

  13. Design of the reactor coolant system and associated systems in nuclear power plants. Safety guide (Spanish Edition)

    International Nuclear Information System (INIS)

    2010-01-01

    This Safety Guide was prepared under the IAEA programme for establishing safety standards for nuclear power plants. The basic requirements for the design of safety systems for nuclear power plants are established in the Safety Requirements publication, Safety Standards Series No. NS-R-1 on Safety of Nuclear Power Plants: Design, which it supplements. This Safety Guide describes how the requirements for the design of the reactor coolant system (RCS) and associated systems in nuclear power plants should be met. This publication is a revision and combination of two previous Safety Guides, Safety Series No. 50-SG-D6 on Ultimate Heat Sink and Directly Associated Heat Transport Systems for Nuclear Power Plants (1982), and Safety Series No. 50-SG-D13 on Reactor Coolant and Associated Systems in Nuclear Power Plants (1987), which are superseded by this new Safety Guide. The revision takes account of developments in the design of the RCS and associated systems in nuclear power plants since the earlier Safety Guides were published in 1982 and 1987, respectively. The other objectives of the revision are to ensure consistency with Ref., issued in 2004, and to update the technical content. In addition, an appendix on pressurized heavy water reactors (PHWRs) has been included.

  14. What Level Design Elements Determine Flow? : How Light and Objects Guide the Player in Overwatch and Doom

    OpenAIRE

    Eliasson, David

    2017-01-01

    This thesis presents a comparative study between Overwatch (2016) and Doom (2016) to determine how these fast-paced games facilitate flow in their gameplay. The second chapter looks at formal definitions of flow and level design to establish a vocabulary for following chapters. Through formal analysis the level designs of both games are then examined to establish what elements in them guide players and keep the flow in gameplay. The thesis also examines how the initial gameplay design princip...

  15. Object-oriented design and programming with C++ your hands-on guide to C++ programming, with special emphasis on design, testing, and reuse

    CERN Document Server

    Leach, Ronald

    2014-01-01

    Object-Oriented Design and Programming with C++: Your Hands-On Guide to C++ Programming, with Special Emphasis on Design, Testing, and Reuse provides a list of software engineering principles to guide the software development process. This book presents the fundamentals of the C++ language.Organized into two parts encompassing 10 chapters, this book begins with an overview of C++ and describes object-oriented programming and the history of C++. This text then introduces classes, polymorphism, inheritance, and overloading. Other chapters consider the C++ preprocessor and organization of class l

  16. Improved survival in rats with glioma using MRI-guided focused ultrasound and microbubbles to disrupt the blood-brain barrier and deliver Doxil

    Science.gov (United States)

    Aryal, Muna; Zhi Zhang, Yong; Vykhodtseva, Natalia; Park, Juyoung; Power, Chanikarn; McDannold, Nathan

    2012-02-01

    Blood-brain-barrier (BBB) limits the transportation of most neuropeptides, proteins (enzymes, antibodies), chemotherapeutic agents, and genes that have therapeutic potential for the treatment of brain diseases. Different methods have been used to overcome this limitation, but they are invasive, non-targeted, or require the development of new drugs. We have developed a method that uses MRI-guided focused ultrasound (FUS) combined with circulating microbubbles to temporarily open BBB in and around brain tumors to deliver chemotherapy agents. Here, we tested whether this noninvasive technique could enhance the effectiveness of a chemotherapy agent (Doxil). Using 690 kHz FUS transducer and microbubble (Definity), we induced BBB disruption in intracranially-implanted 9L glioma tumors in rat's brain in three weekly sessions. Animals who received BBB disruption and Doxil had a median survival time of 34.5 days, which was significantly longer than that found in control animals which is 16, 18.5, 21 days who received no treatment, BBB disruption only and Doxil only respectively This work demonstrates that FUS technique has promise in overcoming barriers to drug delivery, which are particularly stark in the brain due to the BBB.

  17. Guide to good practices for the design, development, and implementation of examinations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    The purpose of this Guide to Good Practices is to provide direction to training personnel in the broad areas of design, development, and implementation of examinations. Nuclear facilities spend a significant amount of training resources testing trainees. Tests are used for employee selection, qualification, requalification, certification and recertification, and promotion. Ineffective testing procedures, or inappropriate interpretation of test results, can have significant effects on both human performance and facility operations. Test development requires unique skills, and as with any skill, training and experience are needed to develop the skills. Test development, test use, test result interpretation, and test refinement, like all other aspects of the systematic approach to training, should be part of an ongoing, systematic process. For some users this document will provide a review of ideas and principles with which they are already familiar; for others it will present new concepts. While not intended to provide in-depth coverage of test theory design and development, it should provide developers, instructors, and evaluators with a foundation on which to develop sound examinations.

  18. Human-system interface design review guideline -- Review software and user's guide: Final report. Revision 1, Volume 3

    International Nuclear Information System (INIS)

    1996-06-01

    NUREG-0700, Revision 1, provides human factors engineering (HFE) guidance to the US Nuclear Regulatory Commission staff for its: (1) review of the human system interface (HSI) design submittals prepared by licensees or applications for a license or design certification of commercial nuclear power plants, and (2) performance of HSI reviews that could be undertaken as part of an inspection or other type of regulatory review involving HSI design or incidents involving human performance. The guidance consists of a review process and HFE guidelines. The document describes those aspects of the HSI design review process that are important to the identification and resolution of human engineering discrepancies that could adversely affect plant safety. Guidance is provided that could be used by the staff to review an applicant's HSI design review process or to guide the development of an HSI design review plan, e.g., as part of an inspection activity. The document also provides detailed HFE guidelines for the assessment of HSI design implementations. NUREG-0700, Revision 1, consists of three stand-alone volumes. Volume 3 contains an interactive software application of the NUREG-0700, Revision 1 guidance and a user's guide for this software. The software supports reviewers during review preparation, evaluation design using the human factors engineering guidelines, and in report preparation. The user's guide provides system requirements and installation instructions, detailed explanations of the software's functions and features, and a tutorial on using the software

  19. From loquacious to reticent: understanding patient health information communication to guide consumer health IT design.

    Science.gov (United States)

    Valdez, Rupa S; Guterbock, Thomas M; Fitzgibbon, Kara; Williams, Ishan C; Wellbeloved-Stone, Claire A; Bears, Jaime E; Menefee, Hannah K

    2017-07-01

    It is increasingly recognized that some patients self-manage in the context of social networks rather than alone. Consumer health information technology (IT) designed to support socially embedded self-management must be responsive to patients' everyday communication practices. There is an opportunity to improve consumer health IT design by explicating how patients currently leverage social media to support health information communication. The objective of this study was to determine types of health information communication patterns that typify Facebook users with chronic health conditions to guide consumer health IT design. Seven hundred participants with type 2 diabetes were recruited through a commercial survey access panel. Cluster analysis was used to identify distinct approaches to health information communication both on and off Facebook. Analysis of variance (ANOVA) methods were used to identify demographic and behavioral differences among profiles. Secondary analysis of qualitative interviews ( n  = 25) and analysis of open-ended survey questions were conducted to understand participant rationales for each profile. Our analysis yielded 7 distinct health information communication profiles. Five of 7 profiles had consistent patterns both on and off Facebook, while the remaining 2 demonstrated distinct practices, with no health information communication on Facebook but some off Facebook. One profile was distinct from all others in both health information communication practices and demographic composition. Rationales for following specific health information communication practices were categorized under 6 themes: altruism, instrumental support, social support, privacy and stigma, convenience, and Facebook knowledge. Facebook has been widely adopted for health information communication; This study demonstrates that Facebook has been widely adopted for health information communication. It also shows that the ways in which patients communicate health

  20. 10 CFR Appendix I to Part 50 - Numerical Guides for Design Objectives and Limiting Conditions for Operation To Meet the...

    Science.gov (United States)

    2010-01-01

    ... pathways and individual receptors as actually exist at the time the plant is licensed. 2. The... Reactor Effluents SECTION I. Introduction. Section 50.34a provides that an application for a construction... guides on design objectives set forth in this section may be used by an applicant for a construction...

  1. Legionellosis prevention in building water and HVAC systems a practical guide for design, operation and maintenance to minimize the risk

    CERN Document Server

    Joppolo, Cesare Maria; Pitera, Luca Alberto; Angermann, Jean Pierre; Izard, Mark

    2013-01-01

    This Guidebook is a practical guide for design, operation and maintenance to minimize the risk of legionellosis in building water and HVAC systmes. It is devided into several themes such as: Air conditioning of the air (by water – humidification), Production of hot water for washing (fundamentally but not only hot water for washing) and Evaporative cooling tower.

  2. Guiding the Design of Lessons by Using the MAPLET Framework: Matching Aims, Processes, Learner Expertise and Technologies

    Science.gov (United States)

    Ifenthaler, Dirk; Gosper, Maree

    2014-01-01

    This paper introduces the MAPLET framework that was developed to map and link teaching aims, learning processes, learner expertise and technologies. An experimental study with 65 participants is reported to test the effectiveness of the framework as a guide to the design of lessons embedded within larger units of study. The findings indicate the…

  3. Buckling resistance calculation of Guide Thimbles for the mechanical design of fuel assembly type PWR under normal reactor operating conditions

    International Nuclear Information System (INIS)

    Cruz, C.B.L.

    1990-01-01

    The calculations demonstrate the fulfillment of one of the mechanical design criteria for the Fuel Assembly Structure under normal reactor operating conditions. The calculations of stresses in the Guide Thimbles are performed with the aid of the program ANSYS. This paper contains program parameters and modelling of a typical Fuel Assembly for a Reactor similar to ANGRA II. (author)

  4. Assessing Online Learning Objects: Student Evaluation of a Guide on the Side Interactive Learning Tutorial Designed by SRJC Libraries

    Science.gov (United States)

    Virtue, Alicia; Dean, Ellen; Matheson, Molly

    2014-01-01

    More and more of today's scholars conduct their research in a digital realm rather than using a print collection. The University of Arizona Libraries Guide on the Side tutorial software offers an opportunity to apply the principles of active learning with real world research scenarios. This paper reports on the design and introduction of…

  5. Guide to safe work : fatigue management : an employer's guide to designing and implementing a fatigue management program. 2 ed.

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-02-15

    The impacts of fatigue on workplace safety are now commonly recognized. Many employers now wish to include fatigue management as part of their overall health and safety programs. This guide to fatigue management was written to help companies in the petroleum industry design and implement effective fatigue management programs that reduce incidents and injuries among employees. The guide provided information about workplace fatigue and discussed fatigue management issues and strategies. It was suggested that workplace culture can play a significant role in managing fatigue by allowing fatigue factors to be quickly recognized and managed. Employers who wish to build fatigue management programs should involve all levels of employees, and should consider all workplace practices and procedures. Consideration must also be given to the development of employee competency in managing fatigue. The guide included step-by-step recommendations for implementing a fatigue management program. It was concluded that the benefits of fatigue management include reduced worker absence and turnover, as well as avoiding the costs of safety incidents. 1 tab., 1 fig.

  6. An A-76 Survival Guide

    Science.gov (United States)

    2002-04-09

    25 THE SAVINGS BUGABOO ...fail to capture some important costs, particularly initial investment costs to conduct the competition and implement the contract or MEO (e.g...would be well spent as current employees are aware that the government continues to look at outsourcing more functions. CONCLUSION THE SAVINGS BUGABOO

  7. Reporting combined outcomes with Trifecta and survival, continence, and potency (SCP) classification in 337 patients with prostate cancer treated with image-guided hypofractionated radiotherapy.

    Science.gov (United States)

    Jereczek-Fossa, Barbara A; Zerini, Dario; Fodor, Cristiana; Santoro, Luigi; Maucieri, Andrea; Gerardi, Marianna A; Vischioni, Barbara; Cambria, Raffaella; Garibaldi, Cristina; Cattani, Federica; Vavassori, Andrea; Matei, Deliu V; Musi, Gennaro; De Cobelli, Ottavio; Orecchia, Roberto

    2014-12-01

    To report the image-guided hypofractionated radiotherapy (hypo-IGRT) outcome for patients with localised prostate cancer according to the new outcome models Trifecta (cancer control, urinary continence, and sexual potency) and SCP (failure-free survival, continence and potency). Between August 2006 and January 2011, 337 patients with cT1-T2N0M0 prostate cancer (median age 73 years) were eligible for a prospective longitudinal study on hypo-IGRT (70.2 Gy/26 fractions) in our Department. Patients completed four questionnaires before treatment, and during follow-up: the International Index of Erectile Function-5 (IIEF-5), the International Prostate Symptom Score (IPSS), and the European Organization for Research and Treatment of Cancer prostate-cancer-specific Quality of Life Questionnaires (QLQ) QLQ-PR25 and QLQ-C30. Baseline and follow-up patient data were analysed according to the Trifecta and SCP outcome models. Cancer control, continence and potency were defined respectively as no evidence of disease, score 1 or 2 for item 36 of the QLQ-PR25 questionnaire, and total score of >16 on the IIEF-5 questionnaire. Patients receiving androgen-deprivation therapy (ADT) at any time were excluded. Trifecta criteria at baseline were met in 72 patients (42% of all ADT-free patients with completed questionnaires). Both at 12 and 24 months after hypo-IGRT, 57% of the Trifecta patients at baseline were still meeting the Trifecta criteria (both oncological and functional success according to the SCP model). The main reason for failing the Trifecta criteria during follow-up was erectile dysfunction: in 18 patients after 6 months follow-up, in 12 patients after 12 months follow-up, and in eight patients after 24 months. Actuarial 2-year Trifecta failure-free survival rate was 44% (95% confidence interval 27-60%). In multivariate analysis no predictors of Trifecta failure were identified. Missing questionnaires was the main limitation of the study. The Trifecta and SCP

  8. Design of a multifiber light delivery system for photoacoustic-guided surgery

    Science.gov (United States)

    Eddins, Blackberrie; Bell, Muyinatu A. Lediju

    2017-04-01

    This work explores light delivery optimization for photoacoustic-guided minimally invasive surgeries, such as the endonasal transsphenoidal approach. Monte Carlo simulations were employed to study three-dimensional light propagation in tissue, comprising one or two 4-mm diameter arteries located 3 mm below bone, an absorbing metallic drill contacting the bone surface, and a single light source placed next to the 2.4-mm diameter drill shaft with a 2.9-mm diameter spherical drill tip. The optimal fiber distance from the drill shaft was determined from the maximum normalized fluence to the underlying artery. Using this optimal fiber-to-drill shaft distance, Zemax simulations were employed to propagate Gaussian beams through one or more 600 micron-core diameter optical fibers for detection on the bone surface. When the number of equally spaced fibers surrounding the drill increased, a single merged optical profile formed with seven or more fibers, determined by thresholding the resulting light profile images at 1/e times the maximum intensity. We used these simulations to inform design requirements, build a one to seven multifiber light delivery prototype to surround a surgical drill, and demonstrate its ability to simultaneously visualize the tool tip and blood vessel targets in the absence and presence of bone. The results and methodology are generalizable to multiple interventional photoacoustic applications.

  9. A Policymaker's Guide to Feed-in Tariff Policy Design

    Energy Technology Data Exchange (ETDEWEB)

    Couture, Toby D. [E3 Analytics, Berlin (Germany); Cory, Karlynn [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kreycik, Claire [National Renewable Energy Lab. (NREL), Golden, CO (United States); Williams, Emily [U.S. Dept. of Energy, Washington, DC (United States)

    2010-07-01

    Feed-in tariffs (FITs) are the most widely used renewable energy policy in the world for driving accelerating renewable energy (RE) deployment, accounting for a greater share of RE development than either tax incentives or renewable portfolio standard (RPS) policies. FITs have generated significant RE deployment, helping bring the countries that have implemented them successfully to the forefront of the global RE industry. In the European Union (EU), FIT policies have led to the deployment of more than 15,000 MW of solar photovoltaic (PV) power and more than 55,000 MW of wind power between 2000 and the end of 2009. In total, FITs are responsible for approximately 75% of global PV and 45% of global wind deployment. Countries such as Germany, in particular, have demonstrated that FITs can be used as a powerful policy tool to drive RE deployment and help meet combined energy security and emissions reductions objectives. This policymaker’s guide provides a detailed analysis of FIT policy design and implementation and identifies a set of best practices that have been effective at quickly stimulating the deployment of large amounts of RE generation.

  10. Policymaker's Guide to Feed-in Tariff Policy Design

    Energy Technology Data Exchange (ETDEWEB)

    Couture, T. D.; Cory, K.; Kreycik, C.; Williams, E.

    2010-07-01

    Feed-in tariffs (FITs) are the most widely used renewable energy policy in the world for driving accelerating renewable energy (RE) deployment, accounting for a greater share of RE development than either tax incentives or renewable portfolio standard (RPS) policies. FITs have generated significant RE deployment, helping bring the countries that have implemented them successfully to the forefront of the global RE industry. In the European Union (EU), FIT policies have led to the deployment of more than 15,000 MW of solar photovoltaic (PV) power and more than 55,000 MW of wind power between 2000 and the end of 2009. In total, FITs are responsible for approximately 75% of global PV and 45% of global wind deployment. Countries such as Germany, in particular, have demonstrated that FITs can be used as a powerful policy tool to drive RE deployment and help meet combined energy security and emissions reductions objectives. This policymaker's guide provides a detailed analysis of FIT policy design and implementation and identifies a set of best practices that have been effective at quickly stimulating the deployment of large amounts of RE generation. Although the discussion is aimed primarily at decision makers who have decided that a FIT policy best suits their needs, exploration of FIT policies can also help inform a choice among alternative renewable energy policies.

  11. Image-Guided Stereotactic Radiosurgery Using a Specially Designed High-Dose-Rate Linac

    International Nuclear Information System (INIS)

    Bayouth, John E.; Kaiser, Heather S.; Smith, Mark C.; Pennington, Edward C.; Anderson, Kathleen M. C.; Ryken, Timothy C.; Buatti, John M.

    2007-01-01

    Stereotactic radiosurgery and image-guided radiotherapy (IGRT) place enhanced demands on treatment delivery machines. In this study, we describe a high-dose-rate output accelerator as a part of our stereotactic IGRT delivery system. The linac is a Siemens Oncor without a flattening filter, and enables dose rates to reach 1000 monitor units (MUs) per minute. Even at this high-dose-rate, the linac dosimetry system remains robust; constancy, linearity, and beam energy remain within 1% for 3 to 1000 MU. Dose profiles for larger field sizes are not flat, but they are radially symmetric and, as such, able to be modeled by a treatment planning system. Target localization is performed via optical guidance utilizing a 3-dimensional (3D) ultrasound probe coupled to an array of 4 infrared light-emitting diodes. These diodes are identified by a fixed infrared camera system that determines diode position and, by extension, all objects imaged in the room coordinate system. This system provides sub-millimeter localization accuracy for cranial applications and better than 1.5 mm for extracranial applications. Because stereotactic IGRT can require significantly longer times for treatment delivery, the advantages of the high-dose-rate design and its direct impact on IGRT are discussed

  12. Guided-mode resonant solar cells and flat-top reflectors: Analysis, design, fabrication and characterization

    Science.gov (United States)

    Khaleque, Tanzina

    This dissertation addresses the guided-mode resonance (GMR) effect and its applications. In particular, this study presents theoretical analysis and corresponding experiments on two important GMR devices that can be broadly described as GMR-enabled thin-film solar cells and flat-top reflectors. The GMR-induced enhanced absorption of input light is observed and quantified in a fabricated nano-patterned amorphous silicon (a-Si) thin-film. Compared to a reference homogeneous thin-film of a-Si, approximately 50% integrated absorbance enhancement is achieved in the patterned structure. This result motivates the application of these resonance effects in thin-film solar cells where enhanced solar absorbance is a crucial requirement. Light trapping in thin-film solar cells through the GMR effect is theoretically explained and experimentally demonstrated. Nano-patterned solar cells with 300-nm periods in one-dimensional gratings are designed, fabricated, and characterized. Compared to a planar reference solar cell, around 35% integrated absorption enhancement is observed over the 450--750-nm wavelength range. This light-management method results in enhanced short-circuit current density of 14.8 mA/cm 2, which is a ˜40% improvement over planar solar cells. The experimental demonstration proves the potential of simple and well-designed guided-mode resonant features in thin-film solar cells. In order to complement the research on GMR thin-film solar cells, a single-step, low-cost fabrication method for generating resonant nano-grating patterns on poly-methyl-methacrylate (PMMA; plexiglas) substrates using thermal nano-imprint lithography is reported. The imprinted structures of both one and two dimensional nano-grating patterns with 300 nm period are fabricated. Thin films of indium-tin-oxide and silicon are deposited over patterned substrates and the absorbance of the films is measured. Around 25% and 45% integrated optical absorbance enhancement is observed over the 450-nm

  13. Survivability Design of Ground Systems for Area Defense Operation in an Urban Scenario

    Science.gov (United States)

    2014-09-01

    vulnerability reduction techniques facilitates identification of important considerations to optimize platform design with a view of the current market ...source market research, equipment online technical specifications, previous studies (Treml 2013), and the intended variations of the identified... Armoured Infantry Fighting Vehicle.” Accessed August 6. http://www.armyrecognition.com/ united_states_american_army_light_armoured_vehicle

  14. Preliminary design of high-power wave-guide/transmission system

    Indian Academy of Sciences (India)

    ... CW klystron followed by wave-guide filter, dual directional coupler, high-power circulator, three 3 dB magic TEE power dividers to split the main channel into four equal channels of 250 kW each. Each individual channel has dual directional couplers, flexible wave-guide sections and high power ceramic vacuum window.

  15. New design for the UCO/Lick Observatory CCD guide camera

    Science.gov (United States)

    Wei, Mingzhi; Stover, Richard J.

    1996-03-01

    A new CCD based field acquisition and telescope guiding camera is being designed and built at UCO/Lick Observatory. Our goal is a camera which is fully computer controllable, compact in size, versatile enough to provide a wide variety of image acquisition modes, and able to operate with a wide variety of CCD detectors. The camera will improve our remote-observing capabilities since it will be easy to control the camera and obtain images over the Observatory computer network. To achieve the desired level of operating flexibility, the design incorporates state-of-the-art technologies such as high density, high speed programmable logic devices and non-volatile static memory. Various types of CCDs can be used in this system without major modification of the hardware or software. Though fully computer controllable, the camera can be operated as a stand-alone unit with most operating parameters set locally. A stand-alone display subsystem is also available. A thermoelectric device is used to cool the CCD to about -45c. Integration times can be varied over a range of 0.1 to 1000 seconds. High speed pixel skipping in both horizontal and vertical directions allows us to quickly access a selected subarea of the detector. Three different read out speeds allow the astronomer to select between high-speed/high-noise and low-speed/low-noise operation. On- chip pixel binning and MPP operation are also selectable options. This system can provide automatic sky level measurement and subtraction to accommodate dynamically changing background levels.

  16. Design and rationale of the MR-INFORM study: stress perfusion cardiovascular magnetic resonance imaging to guide the management of patients with stable coronary artery disease

    Directory of Open Access Journals (Sweden)

    Hussain Shazia T

    2012-09-01

    Full Text Available Abstract Background In patients with stable coronary artery disease (CAD, decisions regarding revascularisation are primarily driven by the severity and extent of coronary luminal stenoses as determined by invasive coronary angiography. More recently, revascularisation decisions based on invasive fractional flow reserve (FFR have shown improved event free survival. Cardiovascular magnetic resonance (CMR perfusion imaging has been shown to be non-inferior to nuclear perfusion imaging in a multi-centre setting and superior in a single centre trial. In addition, it is similar to invasively determined FFR and therefore has the potential to become the non-invasive test of choice to determine need for revascularisation. Trial design The MR-INFORM study is a prospective, multi-centre, randomised controlled non-inferiority, outcome trial. The objective is to compare the efficacy of two investigative strategies for the management of patients with suspected CAD. Patients presenting with stable angina are randomised into two groups: 1 The FFR-INFORMED group has subsequent management decisions guided by coronary angiography and fractional flow reserve measurements. 2 The MR-INFORMED group has decisions guided by stress perfusion CMR. The primary end-point will be the occurrence of major adverse cardiac events (death, myocardial infarction and repeat revascularisation at one year. Clinical trials.gov identifier NCT01236807. Conclusion MR INFORM will assess whether an initial strategy of CMR perfusion is non-inferior to invasive angiography supplemented by FFR measurements to guide the management of patients with stable coronary artery disease. Non-inferiority of CMR perfusion imaging to the current invasive reference standard (FFR would establish CMR perfusion imaging as an attractive non-invasive alternative to current diagnostic pathways.

  17. Design and validation of a CT-guided robotic system for lung cancer brachytherapy.

    Science.gov (United States)

    Dou, Huaisu; Jiang, Shan; Yang, Zhiyong; Sun, Luqing; Ma, Xiaodong; Huo, Bin

    2017-09-01

    Currently, lung brachytherapy in clinical setting is a complex procedure. Operation accuracy depends on accurate positioning of the template; however, it is difficult to guarantee the positioning accuracy manually. Application of robotic-assisted systems can simplify the procedure and improve the manual positioning accuracy. Therefore, a novel CT-guided robotic system was developed to assist the lung cancer brachytherapy. A four degree-of-freedom (DOF) robot, controlled by a lung brachytherapy treatment planning system (TPS) software, was designed and manufactured to assist the template positioning. Target position of the template can be obtained from the treatment plan, thus the robot is driven to the target position automatically. The robotic system was validated in both the laboratory and the CT environment. In laboratory environment, a 3D laser tracker and an inertial measurement unit (IMU) were used to measure the mechanical accuracy in air, which includes positioning accuracy and position repeatability. Working reliability was also validated in this procedure by observing the response reliability and calculating the position repeatability. Imaging artifacts and accuracy of the robot registration were validated in the CT environment by using an artificial phantom with fiducial markers. CT images were obtained and used to test the image artifact and calculate the registration accuracy. Phantom experiments were conducted to test the accuracy of needle insertion by using a transparent hydrogel phantom with a high imitation artificial phantom. Also, the efficiency was validated in this procedure by comparing time costs in manual positioning with robotic positioning under the same experimental conditions. The robotic system achieved the positioning accuracy of 0.28 ± 0.25 mm and the position repeatability of 0.09 ± 0.11 mm. Experimental results showed that the robot was CT-compatible and responded reliably to the control commands. The mean registration accuracy

  18. Plasmin substrate binding site cooperativity guides the design of potent peptide aldehyde inhibitors.

    Science.gov (United States)

    Swedberg, Joakim E; Harris, Jonathan M

    2011-10-04

    Perioperative bleeding is a cause of major blood loss and is associated with increased rates of postoperative morbidity and mortality. To combat this, antifibrinolytic inhibitors of the serine protease plasmin are commonly used to reduce bleeding during surgery. The most effective and previously widely used of these is the broad range serine protease inhibitor aprotinin. However, adverse clinical outcomes have led to use of alternative serine lysine analogues to inhibit plasmin. These compounds suffer from low selectivity and binding affinity. Consequently, a concerted effort to discover potent and selective plasmin inhibitors has developed. This study used a noncombinatorial peptide library to define plasmin's extended substrate specificity and guide the design of potent transition state analogue inhibitors. The various substrate binding sites of plasmin were found to exhibit a higher degree of cooperativity than had previously been appreciated. Peptide sequences capitalizing on these features produced high-affinity inhibitors of plasmin. The most potent of these, Lys-Met(sulfone)-Tyr-Arg-H [KM(O(2))YR-H], inhibited plasmin with a K(i) of 3.1 nM while maintaining 25-fold selectivity over plasma kallikrein. Furthermore, 125 nM (0.16 μg/mL) KM(O(2))YR-H attenuated fibrinolysis in vitro with an efficacy similar to that of 15 nM (0.20 μg/mL) aprotinin. To date, this is the most potent peptide inhibitor of plasmin that exhibits selectivity against plasma kallikrein, making this compound an attractive candidate for further therapeutic development.

  19. Guide line for operator in beyond design basis events for AHWR

    International Nuclear Information System (INIS)

    Kumar, Mithilesh; Mukhopadhyay, D.; Lele, H.G.; Vaze, K.K.

    2011-01-01

    Enhanced defence-in-depth is incorporated in the proposed Advanced Heavy Water Reactor (AHWR) as a part of their fundamental safety approach to ensure that the levels of protection in defence-in-depth shall be more independent from each other than in existing installation. Safety is enhanced by incorporating into their designs, increased emphasis on inherently safe characteristics and passive systems as a part of their fundamental safety approach. It is ensured that the risk from radiation exposures to workers, the public and the environment during construction/commissioning, operation, and decommissioning, shall be comparable to that of other industrial facilities used for similar purposes. This implies that there will be no need for relocation or evacuation measures outside the plant site, apart from those generic emergency measures developed for any industrial facility. It has been demonstrated by analyses that there is no core damage for PIEs with frequencies more than 10- 10 /year. However some scenarios in residual risk domain are considered to demonstrate that dose at plant boundary is within prescribed acceptable limit. It is also possible to arrest core damage progression at various stages of event progression, by incorporating certain operating procedures, without any release. This paper discusses analyses of such low frequency event with multiple failure under the category of 'Decrease in MHT inventory' where plant related symptoms like channel exit temperature, channel component temperatures, moderator level etc. with respect to time are quantified. The operator guide line has been given for case like Loss of coolant without Emergency core coolant system (ECCS) and loss moderator heat sink. It has been observed that 3.0 kg/s mass flow rate is adequate to capture the rising trend of clad surface temperature. (author)

  20. Guide to the safe design, construction and use of radioisotopic power generators for certain land and sea applications

    International Nuclear Information System (INIS)

    1970-01-01

    The increasing development and production of certain types of radioisotopic power generators has indicated the need for internationally acceptable recommendations to be formulated governing the health and safety aspects of their construction and use. Accordingly, a Joint IAEA/ENEA Working Group was set up in 1966 with the task of studying the health and safety problems associated with such devices. The Working Group met twice, in April and December 1967, and prepared a draft guide to the safe design, construction and use of radioisotopic power generators. This draft guide was circulated in September 1968 to IAEA and ENEA Member States for consideration, and the comments that were subsequently received have formed the basis of a re-examination of the draft text in June 1969 by a joint IAEA/ENEA group of consultants set up by the two Agencies to bring the draft guide to its final form. This guide is intended to facilitate the establishment of an adequate standard of safety in the design, construction, installation and use of radioisotopic power generators, and in their ultimate disposal. The immediate requirement is considered to be in relation to those generators which are in an advanced state of development and production and which are designed for use on land and on o r under the sea. The guide deals mainly with radioisotopic power generators in the power range from about one hundred milliwatts to some hundred watts. However, competent national authorities may adapt these guidelines to generators outside this power range. It has been decided at this stage to exclude consideration of miniature generators for medical use, in watches and in other devices available to the general public. Generators for use in space have also been excluded.

  1. In-vitro study on the accuracy of a simple-design CT-guided stent for dental implants

    International Nuclear Information System (INIS)

    Huh, Young June; Choi, Bo Ram; Huh, Kyung Hoe; Yi, Won Jin; Heo, Min Suk; Lee, Sam Sun; Choi, Soon Chul

    2012-01-01

    An individual surgical stent fabricated from computed tomography (CT) data, called a CT-guided stent, would be useful for accurate installation of implants. The purpose of the present study was to introduce a newly developed CT-guided stent with a simple design and evaluate the accuracy of the stent placement. A resin template was fabricated from a hog mandible and a specially designed plastic plate, with 4 metal balls inserted in it for radiographic recognition, was attached to the occlusal surface of the template. With the surgical stent applied, CT images were taken, and virtual implants were placed using software. The spatial positions of the virtually positioned implants were acquired and implant guiding holes were drilled into the surgical stent using a specially designed 5-axis drilling machine. The surgical stent was placed on the mandible and CT images were taken again. The discrepancy between the central axis of the drilled holes on the second CT images and the virtually installed implants on the first CT images was evaluated. The deviation of the entry point and angulation of the central axis in the reference plane were 0.47±0.27 mm, 0.57±0.23 mm, and 0.64±0.16 degree, 0.57±0.15 degree, respectively. However, for the two different angulations in each group, the 20 degree angulation showed a greater error in the deviation of the entry point than did the 10 degree angulation. The CT-guided template proposed in this study was highly accurate. It could replace existing implant guide systems to reduce costs and effort.

  2. Interface Heuristics and Style Guide Design: An Air Battle Management Case Study

    National Research Council Canada - National Science Library

    Nelson, W. T; Bolia, Robert S

    2005-01-01

    .... An analysis of the content of extensive operator interviews from all relevant platforms preceded the production of a compact style guide based on a few simple heuristics and populated with wire frame...

  3. Greening Federal Facilities: An Energy, Environmental, and Economic Resource Guide for Federal Facility Managers and Designers; Second Edition

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, A.

    2001-05-16

    Greening Federal Facilities, Second Edition, is a nuts-and-bolts resource guide compiled to increase energy and resource efficiency, cut waste, and improve the performance of Federal buildings and facilities. The guide highlights practical actions that facility managers, design and construction staff, procurement officials, and facility planners can take to save energy and money, improve the comfort and productivity of employees, and benefit the environment. It supports a national effort to promote energy and environmental efficiency in the nation's 500,000 Federal buildings and facilities. Topics covered include current Federal regulations; environmental and energy decision-making; site and landscape issues; building design; energy systems; water and wastewater; materials; waste management, and recycling; indoor environmental quality; and managing buildings.

  4. Design and rational for the precision medicine guided treatment for cancer pain pragmatic clinical trial.

    Science.gov (United States)

    Mosley, Scott A; Hicks, J Kevin; Portman, Diane G; Donovan, Kristine A; Gopalan, Priya; Schmit, Jessica; Starr, Jason; Silver, Natalie; Gong, Yan; Langaee, Taimour; Clare-Salzler, Michael; Starostik, Petr; Chang, Young D; Rajasekhara, Sahana; Smith, Joshua E; Soares, Heloisa P; George, Thomas J; McLeod, Howard L; Cavallari, Larisa H

    2018-05-01

    Pain is one of the most burdensome symptoms associated with cancer and its treatment, and opioids are the cornerstone of pain management. Opioid therapy is empirically selected, and patients often require adjustments in therapy to effectively alleviate pain or ameliorate adverse drug effects that interfere with quality of life. There are data suggesting CYP2D6 genotype may contribute to inter-patient variability in response to opioids through its effects on opioid metabolism. Therefore, we aim to determine if CYP2D6 genotype-guided opioid prescribing results in greater reductions in pain and symptom severity and interference with daily living compared to a conventional prescribing approach in patients with cancer. Patients with solid tumors with metastasis and a self-reported pain score ≥ 4/10 are eligible for enrollment and randomized to a genotype-guided or conventional pain management strategy. For patients in the genotype-guided arm, CYP2D6 genotype information is integrated into opioid prescribing decisions. Patients are asked to complete questionnaires regarding their pain, symptoms, and quality of life at baseline and 2, 4, 6, and 8 weeks after enrollment. The primary endpoint is differential change in pain severity by treatment strategy (genotype-guided versus conventional pain management). Secondary endpoints include change in pain and symptom interference with daily living. Pharmacogenetic-guided opioid selection for cancer pain management has potential clinical utility, but current evidence is limited to retrospective and observational studies. Precision Medicine Guided Treatment for Cancer Pain is a pragmatic clinical trial that seeks to determine the utility of CYP2D6 genotype-guided opioid prescribing in patients with cancer. Copyright © 2018 Elsevier Inc. All rights reserved.

  5. Evaluation and rational design of guide RNAs for efficient CRISPR/Cas9-mediated mutagenesis in Ciona.

    Science.gov (United States)

    Gandhi, Shashank; Haeussler, Maximilian; Razy-Krajka, Florian; Christiaen, Lionel; Stolfi, Alberto

    2017-05-01

    The CRISPR/Cas9 system has emerged as an important tool for various genome engineering applications. A current obstacle to high throughput applications of CRISPR/Cas9 is the imprecise prediction of highly active single guide RNAs (sgRNAs). We previously implemented the CRISPR/Cas9 system to induce tissue-specific mutations in the tunicate Ciona. In the present study, we designed and tested 83 single guide RNA (sgRNA) vectors targeting 23 genes expressed in the cardiopharyngeal progenitors and surrounding tissues of Ciona embryo. Using high-throughput sequencing of mutagenized alleles, we identified guide sequences that correlate with sgRNA mutagenesis activity and used this information for the rational design of all possible sgRNAs targeting the Ciona transcriptome. We also describe a one-step cloning-free protocol for the assembly of sgRNA expression cassettes. These cassettes can be directly electroporated as unpurified PCR products into Ciona embryos for sgRNA expression in vivo, resulting in high frequency of CRISPR/Cas9-mediated mutagenesis in somatic cells of electroporated embryos. We found a strong correlation between the frequency of an Ebf loss-of-function phenotype and the mutagenesis efficacies of individual Ebf-targeting sgRNAs tested using this method. We anticipate that our approach can be scaled up to systematically design and deliver highly efficient sgRNAs for the tissue-specific investigation of gene functions in Ciona. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Development, Use and Maintenance of the Design Basis Threat. Implementing Guide (French Edition); Elaboration, utilisation et actualisation de la menace de reference. Guide d'application

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-08-15

    This publication provides guidance on how to develop, use and maintain a design basis threat (DBT). It is intended for decision makers from organizations with roles and responsibilities for the development, use and maintenance of the DBT. This implementing guide describes a DBT; identifies and recommends the roles and responsibilities of organizations that should be involved in the development, use and maintenance of a DBT; describes how to conduct a national threat assessment as a precursor to a DBT; explains how a DBT can be developed; explains how a DBT is incorporated into a State's nuclear security regime; and explains the conditions for a review of the DBT, and how the review and update are conducted.

  7. Application of the MCNPX-McStas interface for shielding calculations and guide design at ESS

    DEFF Research Database (Denmark)

    Klinkby, Esben Bryndt; Bergbäck Knudsen, Erik; Willendrup, Peter Kjær

    2013-01-01

    . The generation and moderation of neutrons is simulated using a full scale MCNPX model of the ESS target monolith. Upon entering the beam extraction region, the individual neutron states are handed to McStas via the MCNPX-McStas interface. McStas transports the neutrons through the beam guide and by using newly......Recently, an interface between the Monte Carlo code MCNPX and the neutron ray-tracing code MCNPX was developed[1]. Based on the expected neutronic performance and guide geometries relevant for the ESS, the combined MCNPX-McStas code is used to calculate dose rates along neutron beam guides...... developed event logging capability, the neutron state parameters corresponding to un-reflected neutrons are recorded at each scattering. This information is handed back to MCNPX where it serves as neutron source input for a second MCNPX simulation. This simulation enables calculation of dose rates...

  8. Design and implementation of a system for treating paediatric patients with stereotactically-guided conformal radiotherapy

    International Nuclear Information System (INIS)

    Adams, Elizabeth J.; Suter, Bridget L.; Warrington, Alan P.; Black, Peter; Saran, Frank; Brada, Michael

    2001-01-01

    Background and purpose: Stereotactically-guided conformal radiotherapy (SCRT) allows the delivery of highly conformal dose distributions to localised brain tumours. This is of particular importance for children, whose often excellent long-term prognosis should be accompanied by low toxicity. The commercial immobilisation system in use at our hospital for adults was felt to be too heavy for children, and precluded the use of anaesthesia, which is sometimes required for paediatric patients. This paper therefore describes the design and implementation of a system for treating children with SCRT. This system needed to be well tolerated by patients, with good access for treating typical childhood malignancies. Materials and methods: A lightweight frame was developed for immobilisation, with a shell-based alternative for patients requiring general anaesthetic. Procedures were set up to introduce the patients to the frame system in order to maximise patient co-operation and comfort. Film measurements were made to assess the impact of the frame on transmission and surface dose. The reproducibility of the systems was assessed using electronic portal images. Results: Both frame and shell systems are in clinical use. The frame weighs 0.6 kg and is well tolerated. It has a transmission of 92-96%, and fields which pass through it deliver surface doses of 58-82% of the dose at d max , compared to 18% when no frame is present. However, the frame is constructed to maximise the availability of unobstructed beam directions. Reproducibility measurements for the frame showed a mean random error of 1.0±0.2 mm in two dimensions (2D) and 1.4±0.7 mm in 3D. The mean systematic error in 3D was 2.2 mm, and 90% of all overall 3D errors were less than 3.4 mm. For the shell system, the mean 2D random error was 1.5±0.2 mm. Conclusions: Two well-tolerated immobilisation devices have been developed for fractionated SCRT treatment of paediatric patients. A lightweight frame system gives a wide

  9. Design and implementation of a system for treating paediatric patients with stereotactically-guided conformal radiotherapy.

    Science.gov (United States)

    Adams, E J; Suter, B L; Warrington, A P; Black, P; Saran, F; Brada, M

    2001-09-01

    Stereotactically-guided conformal radiotherapy (SCRT) allows the delivery of highly conformal dose distributions to localised brain tumours. This is of particular importance for children, whose often excellent long-term prognosis should be accompanied by low toxicity. The commercial immobilisation system in use at our hospital for adults was felt to be too heavy for children, and precluded the use of anaesthesia, which is sometimes required for paediatric patients. This paper therefore describes the design and implementation of a system for treating children with SCRT. This system needed to be well tolerated by patients, with good access for treating typical childhood malignancies. A lightweight frame was developed for immobilisation, with a shell-based alternative for patients requiring general anaesthetic. Procedures were set up to introduce the patients to the frame system in order to maximise patient co-operation and comfort. Film measurements were made to assess the impact of the frame on transmission and surface dose. The reproducibility of the systems was assessed using electronic portal images. Both frame and shell systems are in clinical use. The frame weighs 0.6 kg and is well tolerated. It has a transmission of 92-96%, and fields which pass through it deliver surface doses of 58-82% of the dose at d(max), compared to 18% when no frame is present. However, the frame is constructed to maximise the availability of unobstructed beam directions. Reproducibility measurements for the frame showed a mean random error of 1.0+/-0.2mm in two dimensions (2D) and 1.4+/-0.7 mm in 3D. The mean systematic error in 3D was 2.2mm, and 90% of all overall 3D errors were less than 3.4mm. For the shell system, the mean 2D random error was 1.5+/-0.2mm. Two well-tolerated immobilisation devices have been developed for fractionated SCRT treatment of paediatric patients. A lightweight frame system gives a wide range of possible unobstructed beam directions, although beams that

  10. Functional survival after acute care for severe head injury at a designated trauma center in Hong Kong.

    Science.gov (United States)

    Taw, Benedict B T; Lam, Alan C S; Ho, Faith L Y; Hung, K N; Lui, W M; Leung, Gilberto K K

    2012-07-01

    Severe head injury is known to be a major cause of early mortalities and morbidities. Patients' long-term outcome after acute care, however, has not been widely studied. We aim to review the outcome of severely head-injured patients after discharge from acute care at a designated trauma center in Hong Kong. This is a retrospective study of prospectively collected data of patients admitted with severe head injuries between 2004 and 2008. Patients' functional status post-discharge was assessed using the Extended Glasgow Outcome Score (GOSE). Of a total of 1565 trauma patients, 116 had severe head injuries and 41 of them survived acute hospital care. Upon the last follow-up, 23 (56.1%) of the acute-care survivors had improvements in their GOSE, six (11.8%) experienced deteriorations, and 12 (23.5%) did not exhibit any change. The greatest improvement was observed in patients with GOSE of 5 and 6 upon discharge, but two of the 16 patients with GOSE 2 or 3 also had a good recovery. On logistic regression analysis, old age and prolonged acute hospital stay were found to be independent predictors of poor functional outcome after a mean follow-up duration of 42 months. Multidisciplinary neurorehabilitation service is an important component of comprehensive trauma care. Despite significant early mortalities, a proportion of severely head-injured patients who survive acute care may achieve good long-term functional recovery. Copyright © 2012, Asian Surgical Association. Published by Elsevier Taiwan LLC. All rights reserved.

  11. Application of the MCNPX-McStas interface for shielding calculations and guide design at ESS

    DEFF Research Database (Denmark)

    Klinkby, Esben Bryndt; Bergbäck Knudsen, Erik; Willendrup, Peter Kjær

    2014-01-01

    Recently, an interface between the Monte Carlo code MCNPX and the neutron ray-tracing code MCNPX was developed [1, 2]. Based on the expected neutronic performance and guide geometries relevant for the ESS, the combined MCNPX-McStas code is used to calculate dose rates along neutron beam guides......, and by using newly developed event logging capability, the neutron state parameters corresponding to un-reflected neutrons are recorded at each scattering. This information is handed back to MCNPX where it serves as neutron source input for a second MCNPX simulation. This simulation enables calculation of dose...

  12. VR-based training and assessment in ultrasound-guided regional anesthesia: from error analysis to system design.

    LENUS (Irish Health Repository)

    2011-01-01

    If VR-based medical training and assessment is to improve patient care and safety (i.e. a genuine health gain), it has to be based on clinically relevant measurement of performance. Metrics on errors are particularly useful for capturing and correcting undesired behaviors before they occur in the operating room. However, translating clinically relevant metrics and errors into meaningful system design is a challenging process. This paper discusses how an existing task and error analysis was translated into the system design of a VR-based training and assessment environment for Ultrasound Guided Regional Anesthesia (UGRA).

  13. Technical Support Document: Development of the Advanced Energy Design Guide for K-12 Schools--30% Energy Savings

    Energy Technology Data Exchange (ETDEWEB)

    Pless, S.; Torcellini, P.; Long, N.

    2007-09-01

    This Technical Support Document describes the process and methodology for the development of the Advanced Energy Design Guide for K-12 School Buildings (K-12 AEDG), a design guidance document intended to provide recommendations for achieving 30% energy savings in K-12 Schools over levels contained in ANSI/ASHRAE/IESNA Standard 90.1-1999, Energy Standard for Buildings Except Low-Rise Residential Buildings. The 30% energy savings target is the first step toward achieving net-zero energy schools; schools that, on an annual basis, draw from outside sources less or equal energy than they generate on site from renewable energy sources.

  14. Guiding Device for Precision Grafting of Peripheral Nerves in Complete Thoracic Spinal Cord Injury: Design and Sizing for Clinical Trial

    Directory of Open Access Journals (Sweden)

    Arvid Frostell

    2018-05-01

    Full Text Available BackgroundIn an effort to translate preclinical success in achieving spinal cord regeneration through peripheral nerve grafts, this study details the design and sizing of a guiding device for precision grafting of peripheral nerves for use in a clinical trial in complete (AIS-A thoracic spinal cord injury (SCI. The device’s design and sizing are compared to a simulation of human spinal cord sizes based on the best available data.MethodsSpinal cord segmental sizes were generated by computer simulation based on data from a meta-analysis recently published by our group. Thoracic segments T2–T12 were plotted, and seven elliptical shapes were positioned across the center of the distribution of sizes. Geometrical measures of error-of-fit were calculated. CAD modeling was used to create cranial and caudal interfaces for the human spinal cord, aiming to guide descending white matter tracts to gray matter at the caudal end of the device and ascending white matter tracts to gray matter at the cranial end of the device. The interfaces were compared qualitatively to the simulated spinal cord sizes and gray-to-white matter delineations.ResultsThe mean error-of-fit comparing simulated spinal cord segments T2–T12 to the best elliptical shape was 0.41 and 0.36 mm, and the 95th percentile was found at 1.3 and 0.98 mm for transverse and anteroposterior diameter, respectively. A guiding device design was reached for capturing the majority of corticospinal axons at the cranial end of the device and guiding them obliquely to gray matter at the caudal end of the device. Based on qualitative comparison, the vast majority of spinal cord sizes generated indicate an excellent fit to the device’s interfaces.ConclusionA set of SCI guiding devices of seven sizes can cover the variability of human thoracic spinal cord segments T2–T12 with an acceptable error-of-fit for the elliptical shape as well as guiding channels. The computational framework developed can

  15. Guided-mode resonant filters and reflectors: Principles, design, and fabrication

    Science.gov (United States)

    Niraula, Manoj

    angular full-width at half-maximum linewidth of 9.5° compared to a linewidth of 0.1° for classical incidence. Slow angular variation of the central wavelength with full conical incidence arises via a corresponding slow angular variation of the resonant second diffraction orders driving the pertinent leaky modes. Moreover, full conical incidence maintains a profile with a single passband as opposed to the formation of two passbands characteristic of resonant subwavelength gratings under classical incidence. Our experimental results demonstrate excellent stability in angle, spectral profile, linewidth, and efficiency. Finally, we propose a novel method of design and fabrication of photonic lattices that incorporates the best of both worlds: a polarized resonant grating can be designed and converted to its unpolarized lattice equivalent using the same design parameters to obtain a similar performance. We show this in context of a single-layer polarized bandpass filter operating at 1550 nm with 100% transmission efficiency. An unpolarized square-hole lattice with identical parameters operates as a bandpass filter at 1560 nm with 70% transmission efficiency. Moreover, conventional laser interference lithography technique for mask patterning is limited to circular-hole photoresist lattice. We propose a method to lay down a metal hard-mask by lifting-off patterned photoresist in two steps for a square-hole lattice. Our comprehensive study provides new principles for easy design and fabrication of square-hole photonic lattices for unpolarized guided-mode resonance applications. (Abstract shortened by ProQuest.).

  16. Development of Draft Regulatory Guide on Accident Analysis for Nuclear Power Plants with New Safety Design Features

    Energy Technology Data Exchange (ETDEWEB)

    Bang, Young Seok; Woo, Sweng Woong; Hwang, Tae Suk [KINS, Daejeon (Korea, Republic of); Sim, Suk K; Hwang, Min Jeong [Environment and Energy Technology, Daejeon (Korea, Republic of)

    2016-05-15

    The present paper discusses the development process of the draft version of regulatory guide (DRG) on accident analysis of the NPP having the NSFD and its result. Based on the consideration on the lesson learned from the previous licensing review, a draft regulatory guide (DRG) on accident analysis for NPP with new safety design features (NSDF) was developed. New safety design features (NSDF) have been introduced to the new constructing nuclear power plants (NPP) since the early 2000 and the issuance of construction permit of SKN Units 3 and 4. Typical examples of the new safety features includes Fluidic Device (FD) within Safety Injection Tanks (SIT), Passive Auxiliary Feedwater System (PAFS), ECCS Core Barrel Duct (ECBD) which were adopted in APR1400 design and/or APR+ design to improve the safety margin of the plants for the postulated accidents of interest. Also several studies of new concept of the safety system such as Hybrid ECCS design have been reported. General and/or specific guideline of accident analysis considering the NSDF has been requested. Realistic evaluation of the impact of NSDF on accident with uncertainty and separated accident analysis accounting the NSDF impact were specified in the DRG. Per the developmental process, identification of key issues, demonstration of the DRG with specific accident with specific NSDF, and improvement of DGR for the key issues and their resolution will be conducted.

  17. Review on conformance of JMTR reactor facility to safety design examination guides for water-cooled reactors for test and research

    International Nuclear Information System (INIS)

    Ide, Hiroshi; Naka, Michihiro; Sakuta, Yoshiyuki; Hori, Naohiko; Matsui, Yoshinori; Miyazawa, Masataka

    2009-03-01

    The safety design examination guides for water-cooled reactors for test and research are formulated as fundamental judgements on the basic design validity for licensing from a viewpoint of the safety. Taking the refurbishment opportunity of the JMTR, the conformance of the JMTR reactor facility to current safety design examination guides was reviewed with licensing documents, annexes and related documents. As a result, it was found that licensing documents fully satisfied the requirements of the current guides. Moreover, it was found that the JMTR reactor facility itself also satisfied the guides requirements as well as the safety performance, since the facility with safety function such as structure, systems, devices had been installed based on the licensing documents under the permission by the regulation authority. Important devices for safety have been produced under authorization of regulating authority. Therefore, it was confirmed that the licensing was conformed to guides, and that the JMTR has enough performance. (author)

  18. Facilitating Guided Participation through Mobile Technologies: Designing Creative Learning Environments for Self and Others

    Science.gov (United States)

    Evans, Michael A.; Johri, Aditya

    2008-01-01

    We appropriate Rogoff's ("Apprenticeship in thinking: Cognitive development in social context," 1991; in: Wertsch et al. (eds.) "Sociocultural studies of mind," 1993) notion of guided participation to demonstrate, through abbreviated case studies, our strategy for integrating mobile technology-based learning experiences in higher education. Guided…

  19. Masked Visual Analysis: Minimizing Type I Error in Visually Guided Single-Case Design for Communication Disorders.

    Science.gov (United States)

    Byun, Tara McAllister; Hitchcock, Elaine R; Ferron, John

    2017-06-10

    Single-case experimental designs are widely used to study interventions for communication disorders. Traditionally, single-case experiments follow a response-guided approach, where design decisions during the study are based on participants' observed patterns of behavior. However, this approach has been criticized for its high rate of Type I error. In masked visual analysis (MVA), response-guided decisions are made by a researcher who is blinded to participants' identities and treatment assignments. MVA also makes it possible to conduct a hypothesis test assessing the significance of treatment effects. This tutorial describes the principles of MVA, including both how experiments can be set up and how results can be used for hypothesis testing. We then report a case study showing how MVA was deployed in a multiple-baseline across-subjects study investigating treatment for residual errors affecting rhotics. Strengths and weaknesses of MVA are discussed. Given their important role in the evidence base that informs clinical decision making, it is critical for single-case experimental studies to be conducted in a way that allows researchers to draw valid inferences. As a method that can increase the rigor of single-case studies while preserving the benefits of a response-guided approach, MVA warrants expanded attention from researchers in communication disorders.

  20. Agent-Oriented Embedded Control System Design and Development of a Vision-Based Automated Guided Vehicle

    Directory of Open Access Journals (Sweden)

    Wu Xing

    2012-07-01

    Full Text Available This paper presents a control system design and development approach for a vision-based automated guided vehicle (AGV based on the multi-agent system (MAS methodology and embedded system resources. A three-phase agent-oriented design methodology Prometheus is used to analyse system functions, construct operation scenarios, define agent types and design the MAS coordination mechanism. The control system is then developed in an embedded implementation containing a digital signal processor (DSP and an advanced RISC machine (ARM by using the multitasking processing capacity of multiple microprocessors and system services of a real-time operating system (RTOS. As a paradigm, an onboard embedded controller is designed and developed for the AGV with a camera detecting guiding landmarks, and the entire procedure has a high efficiency and a clear hierarchy. A vision guidance experiment for our AGV is carried out in a space-limited laboratory environment to verify the perception capacity and the onboard intelligence of the agent-oriented embedded control system.

  1. Building bridges between theory and practice in medical education using a design-based research approach: AMEE Guide No. 60.

    Science.gov (United States)

    Dolmans, Diana H J M; Tigelaar, D

    2012-01-01

    Medical education research has grown enormously over the past 20 years, but it does not sufficiently make use of theories, according to influential leaders and researchers in this field. In this AMEE Guide, it is argued that design-based research (DBR) studies should be conducted much more in medical education design research because these studies both advance the testing and refinement of theories and advance educational practice. In this Guide, the essential characteristics of DBR as well as how DBR differs from other approach such as formative evaluation are explained. It is also explained what the pitfalls and challenges of DBR are. The main challenges deal with how to insure that DBR studies reveal findings that are of a broader relevance than the local situation and how to insure that DBR contributes toward theory testing and refinement. An example of a series of DBR studies on the design of a teaching portfolio in higher education that is aimed at stimulating a teacher's professional development is described, to illustrate how DBR studies actually work in practice. Finally, it is argued that DBR-studies could play an important role in the advancement of theory and practice in the two broad domains of designing or redesigning work-based learning environments and assessment programs.

  2. Evaluating clinical and public health interventions: a practical guide to study design and statistics

    National Research Council Canada - National Science Library

    Katz, Mitchell H

    2010-01-01

    .... Because the choice of research design depends on the nature of the intervention, the book covers randomized and nonrandomized designs, prospective and retrospective studies, planned clinical trials...

  3. Design and application of model for training ultrasound-guided vascular cannulation in pediatric patients.

    Science.gov (United States)

    Pérez-Quevedo, O; López-Álvarez, J M; Limiñana-Cañal, J M; Loro-Ferrer, J F

    2016-01-01

    Central vascular cannulation is not a risk-free procedure, especially in pediatric patients. Newborn and infants are small and low-weighted, their vascular structures have high mobility because of tissue laxity and their vessels are superficial and with small diameter. These characteristics, together with the natural anatomical variability and poor collaboration of small children, make this technique more difficult to apply. Therefore, ultrasound imaging is increasingly being used to locate vessels and guide vascular access in this population. (a) To present a model that simulates the vascular system for training ultrasound-guided vascular access in pediatrics patients; (b) to ultrasound-guided vascular cannulation in the model. The model consisted of two components: (a) muscular component: avian muscle, (b) vascular component: elastic tube-like structure filled with fluid. 864 ecoguided punctures was realized in the model at different vessel depth and gauge measures were simulated, for two medical operators with different degree of experience. The average depth and diameter of vessel cannulated were 1.16 (0.42)cm and 0.43 (0.1)cm, respectively. The average number of attempts was of 1.22 (0.62). The percentage of visualization of the needle was 74%. The most frequent maneuver used for the correct location, was the modification of the angle of the needle and the relocation of the guidewire in 24% of the cases. The average time for the correct cannulations was 41 (35.8)s. The more frequent complications were the vascular perforation (11.9%) and the correct vascular puncture without possibility of introducing the guidewire (1.2%). The rate of success was 96%. The model simulates the anatomy (vascular and muscular structures) of a pediatric patient. It is cheap models, easily reproducible and a useful tool for training in ultrasound-guided puncture and cannulation. Copyright © 2015 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.

  4. Developing a theory to guide the process of designing information retrieval systems

    DEFF Research Database (Denmark)

    Sonnenwald, Diane H.

    1992-01-01

    This research attempts to develop a descriptive design model that accounts for communication among users, designers, and developer throughout the design process. A pilot study has been completed and a preliminary model that represents a first step in understanding participants' evolving perceptio...... and expectations of the design process and its outcomes is described in this paper....

  5. Image-guided macular laser therapy: design considerations and progress toward implementation

    Science.gov (United States)

    Berger, Jeffrey W.; Shin, David S.

    1999-06-01

    Laser therapy is currently the only treatment of proven benefit for exudative age related macular degeneration and diabetic retinopathy. To guide treatment for macular diseases, investigations were initiated to permit overlay of previously-stored angiographic images and image sequences superimposed onto the real-time biomicroscopic fundus image. Prior to treatment, a set of partially overlapping fundus images is acquired and montaged in order to provide a map for subsequent tracking operations. A binocular slit-lamp biomicroscope interfaced to a CCD camera, framegrabber board, and PC permits acquisition and rendering of retinal images. Computer-vision algorithms facilitate robust tracking, registration, and near-video-rate image overlay of previously-stored retinal photographic and angiographic images onto the real-time fundus image. Laser treatment is guided in this augmented reality environment where the borders of the treatment target--for example, the boundaries of a choroidal neovascularization complex--are easily identified through overlay of angiographic information superimposed on, and registered with, the real-time fundus image. During periods of misregistration as judged by the amplitude of the tracking similarity metric, laser function is disabled, affording additional safety. Image-guided macular laser therapy should facilitate accurate targeting of treatable lesions and less unintentional retinal injury when compared with standard techniques.

  6. Masters Thesis- Criticality Alarm System Design Guide with Accompanying Alarm System Development for the Radioisotope Production Laboratory in Richland, Washington

    Energy Technology Data Exchange (ETDEWEB)

    Greenfield, Bryce A. [Univ. of New Mexico, Albuquerque, NM (United States)

    2009-12-01

    A detailed instructional manual was created to guide criticality safety engineers through the process of designing a criticality alarm system (CAS) for Department of Energy (DOE) hazard class 1 and 2 facilities. Regulatory and technical requirements were both addressed. A list of design tasks and technical subtasks are thoroughly analyzed to provide concise direction for how to complete the analysis. An example of the application of the design methodology, the Criticality Alarm System developed for the Radioisotope Production Laboratory (RPL) of Richland, Washington is also included. The analysis for RPL utilizes the Monte Carlo code MCNP5 for establishing detector coverage in the facility. Significant improvements to the existing CAS were made that increase the reliability, transparency, and coverage of the system.

  7. Design principles for cancer therapy guided by changes in complexity of protein-protein interaction networks.

    Science.gov (United States)

    Benzekry, Sebastian; Tuszynski, Jack A; Rietman, Edward A; Lakka Klement, Giannoula

    2015-05-28

    The ever-increasing expanse of online bioinformatics data is enabling new ways to, not only explore the visualization of these data, but also to apply novel mathematical methods to extract meaningful information for clinically relevant analysis of pathways and treatment decisions. One of the methods used for computing topological characteristics of a space at different spatial resolutions is persistent homology. This concept can also be applied to network theory, and more specifically to protein-protein interaction networks, where the number of rings in an individual cancer network represents a measure of complexity. We observed a linear correlation of R = -0.55 between persistent homology and 5-year survival of patients with a variety of cancers. This relationship was used to predict the proteins within a protein-protein interaction network with the most impact on cancer progression. By re-computing the persistent homology after computationally removing an individual node (protein) from the protein-protein interaction network, we were able to evaluate whether such an inhibition would lead to improvement in patient survival. The power of this approach lied in its ability to identify the effects of inhibition of multiple proteins and in the ability to expose whether the effect of a single inhibition may be amplified by inhibition of other proteins. More importantly, we illustrate specific examples of persistent homology calculations, which correctly predict the survival benefit observed effects in clinical trials using inhibitors of the identified molecular target. We propose that computational approaches such as persistent homology may be used in the future for selection of molecular therapies in clinic. The technique uses a mathematical algorithm to evaluate the node (protein) whose inhibition has the highest potential to reduce network complexity. The greater the drop in persistent homology, the greater reduction in network complexity, and thus a larger

  8. ?Off-Spotter?: very fast and exhaustive enumeration of genomic lookalikes for designing CRISPR/Cas guide RNAs

    OpenAIRE

    Pliatsika, Venetia; Rigoutsos, Isidore

    2015-01-01

    Background CRISPR/Cas (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated nucleases) is a powerful component of the prokaryotic immune system that has been adapted for targeted genetic engineering in higher organisms. A key element of CRISPR/Cas is the ?guide? RNA (gRNA) that is ~20 nucleotides (nts) in length and designed to be complementary to the intended target site. An integral requirement of the CRISPR/Cas system is that the target site be followed by a protospa...

  9. A randomized controlled trial of long term effect of BCM guided fluid management in MHD patients (BOCOMO study: rationales and study design

    Directory of Open Access Journals (Sweden)

    Liu Li

    2012-09-01

    Full Text Available Abstract Background Bioimpedance analysis (BIA has been reported as helpful in identifying hypervolemia. Observation data showed that hypervolemic maintenance hemodialysis (MHD patients identified using BIA methods have higher mortality risk. However, it is not known if BIA-guided fluid management can improve MHD patients’ survival. The objectives of the BOCOMO study are to evaluate the outcome of BIA guided fluid management compared with standard care. Methods This is a multicenter, prospective, randomized, controlled trial. More than 1300 participants from 16 clinical sites will be included in the study. The enrolment period will last 6 months, and minimum length of follow-up will be 36 months. MHD patients aged between 18 years and 80 years who have been on MHD for at least 3 months and meet eligibility criteria will be invited to participate in the study. Participants will be randomized to BIA arm or control arm in a 1:1 ratio. A portable whole body bioimpedance spectroscopy device (BCM—Fresenius Medical Care D GmbH will be used for BIA measurement at baseline for both arms of the study. In the BIA arm, additional BCM measurements will be performed every 2 months. The primary intent-to-treat analysis will compare outcomes for a composite endpoint of death, acute myocardial infarction, stroke or incident peripheral arterial occlusive disease between groups. Secondary endpoints will include left ventricular wall thickness, blood pressure, medications, and incidence and length of hospitalization. Discussions Previous results regarding the benefit of strict fluid control are conflicting due to small sample sizes and unstable dry weight estimating methods. To our knowledge this is the first large-scale, multicentre, prospective, randomized controlled trial to assess whether BIS-guided volume management improves outcomes of MHD patients. The endpoints of the BOCOMO study are of utmost importance to health care providers. In order to obtain

  10. Developing an analytical tool for evaluating EMS system design changes and their impact on cardiac arrest outcomes: combining geographic information systems with register data on survival rates

    Directory of Open Access Journals (Sweden)

    Sund Björn

    2013-02-01

    Full Text Available Abstract Background Out-of-hospital cardiac arrest (OHCA is a frequent and acute medical condition that requires immediate care. We estimate survival rates from OHCA in the area of Stockholm, through developing an analytical tool for evaluating Emergency Medical Services (EMS system design changes. The study also is an attempt to validate the proposed model used to generate the outcome measures for the study. Methods and results This was done by combining a geographic information systems (GIS simulation of driving times with register data on survival rates. The emergency resources comprised ambulance alone and ambulance plus fire services. The simulation model predicted a baseline survival rate of 3.9 per cent, and reducing the ambulance response time by one minute increased survival to 4.6 per cent. Adding the fire services as first responders (dual dispatch increased survival to 6.2 per cent from the baseline level. The model predictions were validated using empirical data. Conclusion We have presented an analytical tool that easily can be generalized to other regions or countries. The model can be used to predict outcomes of cardiac arrest prior to investment in EMS design changes that affect the alarm process, e.g. (1 static changes such as trimming the emergency call handling time or (2 dynamic changes such as location of emergency resources or which resources should carry a defibrillator.

  11. Flexible design in water and wastewater engineering--definitions, literature and decision guide.

    Science.gov (United States)

    Spiller, Marc; Vreeburg, Jan H G; Leusbrock, Ingo; Zeeman, Grietje

    2015-02-01

    Urban water and wastewater systems face uncertain developments including technological progress, climate change and urban development. To ensure the sustainability of these systems under dynamic conditions it has been proposed that technologies and infrastructure should be flexible, adaptive and robust. However, in literature it is often unclear what these technologies and infrastructure are. Furthermore, the terms flexible, adaptive and robust are often used interchangeably, despite important differences. In this paper we will i) define the terminology, ii) provide an overview of the status of flexible infrastructure design alternatives for water and wastewater networks and treatment, and iii) develop guidelines for the selection of flexible design alternatives. Results indicate that, with the exception of Net Present Valuation methods, there is little research available on the design and evaluation of technologies that can enable flexibility. Flexible design alternatives reviewed include robust design, phased design, modular design, modular/component platform design and design for remanufacturing. As developments in the water sector are driven by slow variables (climate change, urban development), rather than market forces, it is suggested that phased design or component platform designs are suitable for responding to change, while robust design is an option when operations face highly dynamic variability. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Hierarchical Thinking: A Cognitive Tool for Guiding Coherent Decision Making in Design Problem Solving

    Science.gov (United States)

    Haupt, Grietjie

    2018-01-01

    This paper builds on two concepts, the first of which is the extended information processing model of expert design cognition. This proposes twelve internal psychological characteristics interacting with the external world of expert designers during the early phases of the design process. Here, I explore one of the characteristics, hierarchical…

  13. Burnable absorber-integrated Guide Thimble (BigT) - 1. Design concepts and neutronic characterization on the fuel assembly benchmarks

    International Nuclear Information System (INIS)

    Yahya, Mohd-Syukri; Yu, Hwanyeal; Kim, Yonghee

    2016-01-01

    This paper presents the conceptual designs of a new burnable absorber (BA) for the pressurized water reactor (PWR), which is named 'Burnable absorber-integrated Guide Thimble' (BigT). The BigT integrates BA materials into standard guide thimble in a PWR fuel assembly. Neutronic sensitivities and practical design considerations of the BigT concept are points of highlight in the first half of the paper. Specifically, the BigT concepts are characterized in view of its BA material and spatial self-shielding variations. In addition, the BigT replaceability requirement, bottom-end design specifications and thermal-hydraulic considerations are also deliberated. Meanwhile, much of the second half of the paper is devoted to demonstrate practical viability of the BigT absorbers via comparative evaluations against the conventional BA technologies in representative 17x17 and 16x16 fuel assembly lattices. For the 17x17 lattice evaluations, all three BigT variants are benchmarked against Westinghouse's existing BA technologies, while in the 16x16 assembly analyses, the BigT designs are compared against traditional integral gadolinia-urania rod design. All analyses clearly show that the BigT absorbers perform as well as the commercial BA technologies in terms of reactivity and power peaking management. In addition, it has been shown that sufficiently high control rod worth can be obtained with the BigT absorbers in place. All neutronic simulations were completed using the Monte Carlo Serpent code with ENDF/B-VII.0 library. (author)

  14. Comparison and analysis of FDA reported visual outcomes of the three latest platforms for LASIK: wavefront guided Visx iDesign, topography guided WaveLight Allegro Contoura, and topography guided Nidek EC-5000 CATz

    Directory of Open Access Journals (Sweden)

    Moshirfar M

    2017-01-01

    Full Text Available Majid Moshirfar,1,2 Tirth J Shah,3 David Franklin Skanchy,4 Steven H Linn,1 Paul Kang,3 Daniel S Durrie5 1HDR Research Center, Hoopes Vision, Salt Lake City, UT, 2Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, 3University of Arizona College of Medicine – Phoenix, Phoenix, AZ, 4McGovern Medical School, The University of Texas Health Science Center at Houston, TX, 5Durrie Vision, Kansas City, KS, USA Purpose: To compare and analyze the differences in visual outcomes between Visx iDesign Advanced WaveScan Studio™ System, Alcon Wavelight Allegro Topolyzer and Nidek EC-5000 using Final Fit™ Custom Ablation Treatment Software from the submitted summary of safety and effectiveness of the US Food and Drug Administration (FDA data.Methods: In this retrospective comparative study, 334 eyes from Visx iDesign, 212 eyes from Alcon Contour, and 135 eyes from Nidek CATz platforms were analyzed for primary and secondary visual outcomes. These outcomes were compared via side-by-side graphical and tabular representation of the FDA data. Statistical significance was calculated when appropriate to assess differences. A P-value <0.05 was considered statistically significant. Results: The mean postoperative uncorrected distance visual acuity (UDVA at 12 months was 20/19.25±8.76, 20/16.59±5.94, and 20/19.17±4.46 for Visx iDesign, Alcon Contoura, and Nidek CATz, respectively. In at least 90% of treated eyes at 3 months and 12 months, all three lasers showed either no change or a gain of corrected distance visual acuity (CDVA. Mesopic contrast sensitivity at 6 months showed a clinically significant increase of 41.3%, 25.1%, and 10.6% for eyes using Visx iDesign, Alcon Contoura, and Nidek CATz, respectively. Photopic contrast sensitivity at 6 months showed a clinically significant increase of 19.2%, 31.9%, and 10.6% for eyes using Visx iDesign, Alcon Contoura, and Nidek CATz

  15. Image guided brachytherapy in locally advanced cervical cancer: Improved pelvic control and survival in RetroEMBRACE, a multicenter cohort study

    DEFF Research Database (Denmark)

    Sturdza, Alina; Pötter, Richard; Fokdal, Lars Ulrik

    2016-01-01

    Purpose Image guided brachytherapy (IGBT) for locally advanced cervical cancer allows dose escalation to the high-risk clinical target volume (HRCTV) while sparing organs at risk (OAR). This is the first comprehensive report on clinical outcome in a large multi-institutional cohort. Patients and ...

  16. Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial

    DEFF Research Database (Denmark)

    Jensen, Jens U; Hein, Lars; Lundgren, Bettina

    2011-01-01

    For patients in intensive care units, sepsis is a common and potentially deadly complication and prompt initiation of appropriate antimicrobial therapy improves prognosis. The objective of this trial was to determine whether a strategy of antimicrobial spectrum escalation, guided by daily measure...

  17. Functional survival after acute care for severe head injury at a designated trauma center in Hong Kong

    Directory of Open Access Journals (Sweden)

    Benedict B.T. Taw

    2012-07-01

    Conclusion: Multidisciplinary neurorehabilitation service is an important component of comprehensive trauma care. Despite significant early mortalities, a proportion of severely head-injured patients who survive acute care may achieve good long-term functional recovery.

  18. Reliability design of mechanical systems a guide for mechanical and civil engineers

    CERN Document Server

    Woo, Seongwoo

    2017-01-01

    This book describes basic reliability concepts – parametric ALT plan, failure mechanism and design, and reliability testing with acceleration factor and sample size equation. A generalized life-stress failure model with a new effort concept has been derived and recommended to calculate the acceleration factor of the mechanical system. The new sample size equation with the acceleration factor has also been derived to carry out the parametric ALT. This new parametric ALT should help a mechanical/civil engineer to uncover the design parameters affecting reliability during the design process of the mechanical system. Consequently, it should help companies to improve product reliability and avoid recalls due to the product/structure failures in the field. As the improper or missing design parameters in the design phase are experimentally identified by this new reliability design method - parametric ALT, the mechanical/civil engineering system might improve in reliability by the increase in lifetime and the reduc...

  19. The ORNL Modulating Heat Pump Design Tool User's Guide

    Energy Technology Data Exchange (ETDEWEB)

    Rice, C.K.

    2001-06-01

    The ORNL Modulating Heat Pump Design Tool consists of a Modulating HPDM (Heat Pump Design Model) and a parametric-analysis (contour-data generating) front-end. Collectively the program is also referred to as MODCON which is in reference to the modulating and the contour data generating capabilities. The program was developed by Oak Ridge National Laboratory for the Department of Energy to provide a publicly-available system design tool for variable- and single-speed heat pumps.

  20. The ORNL Modulating Heat Pump Design Tool -- Mark IV User's Guide

    Energy Technology Data Exchange (ETDEWEB)

    Rice, C.K.

    2001-09-27

    The ORNL Modulating Heat Pump Design Tool consists of a Modulating HPDM (Heat Pump Design Model) and a parametric-analysis (contour-data generating) front-end. Collectively the program is also referred to as MODCON which is in reference to the modulating and the contour data generating capabilities. The program was developed by Oak Ridge National Laboratory for the Department of Energy to provide a publicly-available system design tool for variable- and single-speed heat pumps.

  1. Design, Implementation and Analysis of Learner-Centered Guided In-Service Programme for Technical Teacher Education

    Directory of Open Access Journals (Sweden)

    Tiia Rüütmann

    2014-03-01

    Full Text Available The design of learner-centered guided in-service program for technical teacher education has been launched at Estonian Centre for Engineering Pedagogy at Tallinn University of Technology. The aim of the program has been facilitating the initial in-service teaching experience, involving mentoring, peer support and cognitive apprenticeship. The emphasis has been on teaching for knowledge application, including the choice of content and processes, motivation, reflection, problem-solving, choice of educational technology, effective teaching methods, teaching models and strategies ཿ concepts, tools and procedures of the field of engineering, organized in ways enabling teachers to formulate real world problems, apply and solve them. The program has been implemented since 2012 and covers IGIP curriculum requirements. In the present article the designed program is described and analyzed.

  2. Microgrid Design Toolkit (MDT) User Guide Software v1.2.

    Energy Technology Data Exchange (ETDEWEB)

    Eddy, John P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-08-01

    The Microgrid Design Toolkit (MDT) supports decision analysis for new ("greenfield") microgrid designs as well as microgrids with existing infrastructure. The current version of MDT includes two main capabilities. The first capability, the Microgrid Sizing Capability (MSC), is used to determine the size and composition of a new, grid connected microgrid in the early stages of the design process. MSC is focused on developing a microgrid that is economically viable when connected to the grid. The second capability is focused on designing a microgrid for operation in islanded mode. This second capability relies on two models: the Technology Management Optimization (TMO) model and Performance Reliability Model (PRM).

  3. The Combined Multi-objective Optimization Design for a Light Guide Rod

    International Nuclear Information System (INIS)

    Yang, Yu-Sen; Fung, Rong-Fong; Shih, Chun-Yao; Chien, Hong-Yao

    2013-01-01

    The light guide rod (LGR) has been popularly used for the vehicles, and the automobile lamp industries need mass production to match this trend. This paper aims to develop a systemic way to find the best parameters' combination for the LGR, and the parameters are usually restricted to some levels and random values. In this paper, the LGR example with two optical performances of illuminance flux and uniformity is to be optimized by use of the real-coded genetic algorithm (RGA) and grey relational analysis (GRA). The illuminance flux and uniformity of the best parameters' combination are obtained and compared with the initial set. Comparisons with Taguchi-Grey can improve 5% of gain and comparisons with Pareto genetic algorithm (PaGA) can improve 1.7% of gain. The combined multi-objective optimization can saving 7% time and it is found that the new proposed method has positive gains in performances.

  4. Design and analysis of ultrasonic monaural audio guiding device for the visually impaired.

    Science.gov (United States)

    Kim, Keonwook; Kim, Hyunjai; Yun, Gihun; Kim, Myungsoo

    2009-01-01

    The novel Audio Guiding Device (AGD) based on the ultrasonic, which is named as SonicID, has been developed in order to localize point of interest for the visually impaired. The SonicID requires the infrastructure of the transmitters for broadcasting the location information over the ultrasonic carrier. The user with ultrasonic headset receives the information with variable amplitude upon the location and direction of the user due to the ultrasonic characteristic and modulation method. This paper proposes the monaural headset form factor of the SonicID which improves the daily life of the beneficiary compare to the previous version which uses the both ears. Experimental results from SonicID, Bluetooth, and audible sound show that the SonicID demonstrates comparable localization performance to the audible sound with silence to others.

  5. Theory-Guided Design of Organic Electro-Optic Materials and Devices

    Directory of Open Access Journals (Sweden)

    Stephanie Benight

    2011-08-01

    Full Text Available Integrated (multi-scale quantum and statistical mechanical theoretical methods have guided the nano-engineering of controlled intermolecular electrostatic interactions for the dramatic improvement of acentric order and thus electro-optic activity of melt-processable organic polymer and dendrimer electro-optic materials. New measurement techniques have permitted quantitative determination of the molecular order parameters, lattice dimensionality, and nanoscale viscoelasticity properties of these new soft matter materials and have facilitated comparison of theoretically-predicted structures and thermodynamic properties with experimentally-defined structures and properties. New processing protocols have permitted further enhancement of material properties and have facilitated the fabrication of complex device structures. The integration of organic electro-optic materials into silicon photonic, plasmonic, and metamaterial device architectures has led to impressive new performance metrics for a variety of technological applications.

  6. Family and Consumer Sciences: A Facility Planning and Design Guide for School Systems.

    Science.gov (United States)

    Maryland State Dept. of Education, Baltimore.

    This document presents design concepts and considerations for planning and developing middle and high school family and consumer sciences education facilities. It includes discussions on family and consumer sciences education trends and the facility planning process. Design concepts explore multipurpose laboratories and spaces for food/nutrition…

  7. Using Importance-Performance Analysis to Guide Instructional Design of Experiential Learning Activities

    Science.gov (United States)

    Anderson, Sheri; Hsu, Yu-Chang; Kinney, Judy

    2016-01-01

    Designing experiential learning activities requires an instructor to think about what they want the students to learn. Using importance-performance analysis can assist with the instructional design of the activities. This exploratory study used importance-performance analysis in an online introduction to criminology course. There is limited…

  8. Immediate Implants Placed in Fresh Sockets Associated with Periapical Pathology: A Split-Mouth Design and Survival Evaluation after 1-Year Follow-Up.

    Science.gov (United States)

    Hita-Iglesias, Cristina; Sánchez-Sánchez, Francisco J; Montero, Javier; Galindo-Moreno, Pablo; Mesa, Francisco; Martínez-Lara, Ildefonso; Sánchez-Fernández, Elena

    2016-12-01

    To compare the immediate implant success rates between sites with chronic apical lesions and healthy sites in the same patients 1 year postdelayed loading. One hundred sixty-eight immediate implants were placed in sixty patients at upper incisor, canine, and premolar sites. A split-mouth design was used, placing a minimum of two implants, one in a fresh socket associated with chronic periapical disease, the average lesion size was larger than 4 mm and less than 8 mm (test group), and the other(s) in a healthy fresh socket (control group). Implant survival rate at 1 year postloading delayed was compared between the groups. The implant survival rate was 98.2% for the total sample (n = 168); out of the three implants lost, two were from the test group, and one was from the control group (in the same patient as one of the former). Among the surviving implants, five were also considered failures due to excessive bone loss (n = 3) and also because of the recurrence of the periapical lesions (n = 2). Survival rates were significantly lower in the test than control sites at 12 months postloading. Implant survival rates were significantly lower after the immediate implantation in postextraction sockets associated with chronic periapical disease (90.8%) than in healthy postextraction sockets (98.1%). © 2015 Wiley Periodicals, Inc.

  9. How to Deal with Interval-Censored Data Practically while Assessing the Progression-Free Survival: A Step-by-Step Guide Using SAS and R Software.

    Science.gov (United States)

    Dugué, Audrey Emmanuelle; Pulido, Marina; Chabaud, Sylvie; Belin, Lisa; Gal, Jocelyn

    2016-12-01

    We describe how to estimate progression-free survival while dealing with interval-censored data in the setting of clinical trials in oncology. Three procedures with SAS and R statistical software are described: one allowing for a nonparametric maximum likelihood estimation of the survival curve using the EM-ICM (Expectation and Maximization-Iterative Convex Minorant) algorithm as described by Wellner and Zhan in 1997; a sensitivity analysis procedure in which the progression time is assigned (i) at the midpoint, (ii) at the upper limit (reflecting the standard analysis when the progression time is assigned at the first radiologic exam showing progressive disease), or (iii) at the lower limit of the censoring interval; and finally, two multiple imputations are described considering a uniform or the nonparametric maximum likelihood estimation (NPMLE) distribution. Clin Cancer Res; 22(23); 5629-35. ©2016 AACR. ©2016 American Association for Cancer Research.

  10. Engineering properties of stabilized subgrade soils for implementation of the AASHTO 2002 pavement design guide.

    Science.gov (United States)

    2009-06-01

    A comprehensive laboratory study was undertaken to determine engineering properties of cementitiously stabilized common subgrade soils in Oklahoma for the design of roadway pavements in accordance with the AASHTO 2002 Mechanistic-Empirical Pavement D...

  11. Technical Support Document: Development of the Advanced Energy Design Guide for Grocery Stores--50% Energy Savings

    Energy Technology Data Exchange (ETDEWEB)

    Hale, E. T.; Macumber, D. L.; Long, N. L.; Griffith, B. T.; Benne, K. S.; Pless, S. D.; Torcellini, P. A.

    2008-09-01

    This report provides recommendations that architects, designers, contractors, developers, owners, and lessees of grocery store buildings can use to achieve whole-building energy savings of at least 50% over ASHRAE Standard 90.1-2004.

  12. Building arrangement and site layout design guides for on site low level radioactive waste storage facilities

    International Nuclear Information System (INIS)

    McMullen, J.W.; Feehan, M.J.

    1986-01-01

    Many papers have been written by AE's and utilities describing their onsite storage facilities, why they are needed, NRC regulations, and disposal site requirements. This paper discusses a typical storage facility and address the design considerations and operational aspects that are generally overlooked when designing and siting a low level radioactive waste storage facility. Some topics to be addressed are: 1. Container flexibility; 2. Modular expansion capabilities; 3. DOT regulations; 4. Meterological requirements; 5. OSHA; 6. Fire protection; 7. Floods; 8. ALARA

  13. CALIOP: a multichannel design code for gas-cooled fast reactors. Code description and user's guide

    International Nuclear Information System (INIS)

    Thompson, W.I.

    1980-10-01

    CALIOP is a design code for fluid-cooled reactors composed of parallel fuel tubes in hexagonal or cylindrical ducts. It may be used with gaseous or liquid coolants. It has been used chiefly for design of a helium-cooled fast breeder reactor and has built-in cross section information to permit calculations of fuel loading, breeding ratio, and doubling time. Optional cross-section input allows the code to be used with moderated cores and with other fuels

  14. Designing a wearable navigation system for image-guided cancer resection surgery.

    Science.gov (United States)

    Shao, Pengfei; Ding, Houzhu; Wang, Jinkun; Liu, Peng; Ling, Qiang; Chen, Jiayu; Xu, Junbin; Zhang, Shiwu; Xu, Ronald

    2014-11-01

    A wearable surgical navigation system is developed for intraoperative imaging of surgical margin in cancer resection surgery. The system consists of an excitation light source, a monochromatic CCD camera, a host computer, and a wearable headset unit in either of the following two modes: head-mounted display (HMD) and Google glass. In the HMD mode, a CMOS camera is installed on a personal cinema system to capture the surgical scene in real-time and transmit the image to the host computer through a USB port. In the Google glass mode, a wireless connection is established between the glass and the host computer for image acquisition and data transport tasks. A software program is written in Python to call OpenCV functions for image calibration, co-registration, fusion, and display with augmented reality. The imaging performance of the surgical navigation system is characterized in a tumor simulating phantom. Image-guided surgical resection is demonstrated in an ex vivo tissue model. Surgical margins identified by the wearable navigation system are co-incident with those acquired by a standard small animal imaging system, indicating the technical feasibility for intraoperative surgical margin detection. The proposed surgical navigation system combines the sensitivity and specificity of a fluorescence imaging system and the mobility of a wearable goggle. It can be potentially used by a surgeon to identify the residual tumor foci and reduce the risk of recurrent diseases without interfering with the regular resection procedure.

  15. Design and implementation of a PC-based image-guided surgical system.

    Science.gov (United States)

    Stefansic, James D; Bass, W Andrew; Hartmann, Steven L; Beasley, Ryan A; Sinha, Tuhin K; Cash, David M; Herline, Alan J; Galloway, Robert L

    2002-11-01

    In interactive, image-guided surgery, current physical space position in the operating room is displayed on various sets of medical images used for surgical navigation. We have developed a PC-based surgical guidance system (ORION) which synchronously displays surgical position on up to four image sets and updates them in real time. There are three essential components which must be developed for this system: (1) accurately tracked instruments; (2) accurate registration techniques to map physical space to image space; and (3) methods to display and update the image sets on a computer monitor. For each of these components, we have developed a set of dynamic link libraries in MS Visual C++ 6.0 supporting various hardware tools and software techniques. Surgical instruments are tracked in physical space using an active optical tracking system. Several of the different registration algorithms were developed with a library of robust math kernel functions, and the accuracy of all registration techniques was thoroughly investigated. Our display was developed using the Win32 API for windows management and tomographic visualization, a frame grabber for live video capture, and OpenGL for visualization of surface renderings. We have begun to use this current implementation of our system for several surgical procedures, including open and minimally invasive liver surgery.

  16. Parameter-free methods distinguish Wnt pathway models and guide design of experiments

    KAUST Repository

    MacLean, Adam L.

    2015-02-17

    The canonical Wnt signaling pathway, mediated by β-catenin, is crucially involved in development, adult stem cell tissue maintenance, and a host of diseases including cancer. We analyze existing mathematical models of Wnt and compare them to a new Wnt signaling model that targets spatial localization; our aim is to distinguish between the models and distill biological insight from them. Using Bayesian methods we infer parameters for each model from mammalian Wnt signaling data and find that all models can fit this time course. We appeal to algebraic methods (concepts from chemical reaction network theory and matroid theory) to analyze the models without recourse to specific parameter values. These approaches provide insight into aspects of Wnt regulation: the new model, via control of shuttling and degradation parameters, permits multiple stable steady states corresponding to stem-like vs. committed cell states in the differentiation hierarchy. Our analysis also identifies groups of variables that should be measured to fully characterize and discriminate between competing models, and thus serves as a guide for performing minimal experiments for model comparison.

  17. A new catheter design for combined radiofrequency ablation and optoacoustic treatment monitoring using copper-coated light-guides

    Science.gov (United States)

    Rebling, Johannes; Oyaga Landa, Francisco Javier; Deán-Ben, Xosé Luis; Razansky, Daniel

    2018-02-01

    Electrosurgery, i.e. the application of radiofrequency current for tissue ablation, is a frequently used treatment for many cardiac arrhythmias. Electrophysiological and anatomic mapping, as well as careful radiofrequency power control typically guide the radiofrequency ablation procedure. Despite its widespread application, accurate monitoring of the lesion formation with sufficient spatio-temporal resolution remains challenging with the existing imaging techniques. We present a novel integrated catheter for simultaneous radiofrequency ablation and optoacoustic monitoring of the lesion formation in real time and 3D. The design combines the delivery of both electric current and optoacoustic excitation beam in a single catheter consisting of copper-coated multimode light-guides and its manufacturing is described in detail. The electrical current causes coagulation and desiccation while the excitation light is locally absorbed, generating OA responses from the entire treated volume. The combined ablation-monitoring capabilities were verified using ex-vivo bovine tissue. The formed ablation lesions showed a homogenous coagulation while the ablation was monitored in realtime with a volumetric frame rate of 10 Hz over 150 seconds.

  18. Creative engineering design assessment background, directions, manual, scoring guide and uses

    CERN Document Server

    Charyton, Christine

    2014-01-01

    The Creative Engineering Design Assessment or CEDA is a newly developed tool to assess creativity specific to engineering design which is vital for innovation. The revised CEDA assesses usefulness in addition to originality.  Both originality and usefulness are key constructs in creativity but are primarily essential and emphasized ever more in engineering design.  Since the preliminary research was presented to the National Science Foundation, further reliability and validity has been developed and established. The CEDA is different from other general creativity measures as it demonstrates discriminant validity with the Creative Personality Scale, Creative Temperament Scale, and the Cognitive Risk Tolerance Scale, and has demonstrated convergent validity with the Purdue Creativity Test and the Purdue Spatial Visualization Test- Rotations. It focuses on engineering specific measures, measuring engineering creativity and spatial skills. The aim of this book is to disseminate the CEDA tool for use in engin...

  19. Engineering a Functional Small RNA Negative Autoregulation Network with Model-Guided Design.

    Science.gov (United States)

    Hu, Chelsea Y; Takahashi, Melissa K; Zhang, Yan; Lucks, Julius B

    2018-05-22

    RNA regulators are powerful components of the synthetic biology toolbox. Here, we expand the repertoire of synthetic gene networks built from these regulators by constructing a transcriptional negative autoregulation (NAR) network out of small RNAs (sRNAs). NAR network motifs are core motifs of natural genetic networks, and are known for reducing network response time and steady state signal. Here we use cell-free transcription-translation (TX-TL) reactions and a computational model to design and prototype sRNA NAR constructs. Using parameter sensitivity analysis, we design a simple set of experiments that allow us to accurately predict NAR function in TX-TL. We transfer successful network designs into Escherichia coli and show that our sRNA transcriptional network reduces both network response time and steady-state gene expression. This work broadens our ability to construct increasingly sophisticated RNA genetic networks with predictable function.

  20. Seismic site evaluation practice and seismic design guide for NPP in Continent of China

    Energy Technology Data Exchange (ETDEWEB)

    Yuxian, Hu [State Seismological Bureau, Beijing, BJ (China). Inst. of Geophysics

    1997-03-01

    Energy resources, seismicity, NPP and related regulations of the Continent of China are briefly introduced in the beginning and two codes related to the seismic design of NPP, one on siting and another on design, are discussed in some detail. The one on siting is an official code of the State Seismological Bureau, which specifies the seismic safety evaluation requirements of various kinds of structures, from the most critic and important structures such as NPP to ordinary buildings, and including also engineering works in big cities. The one on seismic design of NPP is a draft subjected to publication now, which will be an official national code. The first one is somewhat unique but the second one is quite similar to those in the world. (author)

  1. Seismic site evaluation practice and seismic design guide for NPP in Continent of China

    International Nuclear Information System (INIS)

    Hu Yuxian

    1997-01-01

    Energy resources, seismicity, NPP and related regulations of the Continent of China are briefly introduced in the beginning and two codes related to the seismic design of NPP, one on siting and another on design, are discussed in some detail. The one on siting is an official code of the State Seismological Bureau, which specifies the seismic safety evaluation requirements of various kinds of structures, from the most critic and important structures such as NPP to ordinary buildings, and including also engineering works in big cities. The one on seismic design of NPP is a draft subjected to publication now, which will be an official national code. The first one is somewhat unique but the second one is quite similar to those in the world. (author)

  2. Big-deep-smart data in imaging for guiding materials design

    Science.gov (United States)

    Kalinin, Sergei V.; Sumpter, Bobby G.; Archibald, Richard K.

    2015-10-01

    Harnessing big data, deep data, and smart data from state-of-the-art imaging might accelerate the design and realization of advanced functional materials. Here we discuss new opportunities in materials design enabled by the availability of big data in imaging and data analytics approaches, including their limitations, in material systems of practical interest. We specifically focus on how these tools might help realize new discoveries in a timely manner. Such methodologies are particularly appropriate to explore in light of continued improvements in atomistic imaging, modelling and data analytics methods.

  3. Tour Guide Robots: An Integrated Research and Design Platform to Prepare Engineering and Technology Students

    Science.gov (United States)

    Yelamarthi, Kumar

    2016-01-01

    Many interesting research and design questions occur at the intersections of traditional disciplines, yet most coursework and research programs for undergraduate engineering students are focused on one discipline. This leads to underutilization of the potential in better preparing students through multidisciplinary projects. Identifying this…

  4. iRPD--A Framework for Guiding Design-Based Research for iPad Apps

    Science.gov (United States)

    Kucirkova, Natalia

    2017-01-01

    The last 5 years have been marked by an explosion of tablet and smartphone applications designed for young children and several calls to encourage educational researchers to engage in children's app research. This paper presents a novel prospect for educational researchers: to collaboratively research, implement and produce iPad apps for…

  5. How to manage training: a guide to design and delivery for high performance

    National Research Council Canada - National Science Library

    Nilson, Carolyn D

    2003-01-01

    ... Training 312 Chapter 12 How to Evaluate Training 346 Appendix: Models for Individual and Organizational Learning 385 Bibliography 413 Index 419 About the Author 425 v List of FiguresList of Figures Figure 3.1. ISD instructional system design. 80 Figure 3.2. ASTD human performance improvement process model. 81 Figure 3.3. Performance technology m...

  6. Fostering Autonomy through Syllabus Design: A Step-by-Step Guide for Success

    Science.gov (United States)

    Ramírez Espinosa, Alexánder

    2016-01-01

    Promoting learner autonomy is relevant in the field of applied linguistics due to the multiple benefits it brings to the process of learning a new language. However, despite the vast array of research on how to foster autonomy in the language classroom, it is difficult to find step-by-step processes to design syllabi and curricula focused on the…

  7. Practical network design techniques a complete guide for WANs and LANs

    CERN Document Server

    Held, Gilbert

    2004-01-01

    This new edition has two parts. The first part focuses on wide area networks; the second, which is entirely new, focuses on local area networks. Because Ethernet emerged victorious in the LAN war, the second section pays particular attention to Ethernet design and performance characteristics.

  8. Low-Radiation Cellular Inductive Powering of Rodent Wireless Brain Interfaces: Methodology and Design Guide.

    Science.gov (United States)

    Soltani, Nima; Aliroteh, Miaad S; Salam, M Tariqus; Perez Velazquez, Jose Luis; Genov, Roman

    2016-08-01

    This paper presents a general methodology of inductive power delivery in wireless chronic rodent electrophysiology applications. The focus is on such systems design considerations under the following key constraints: maximum power delivery under the allowable specific absorption rate (SAR), low cost and spatial scalability. The methodology includes inductive coil design considerations within a low-frequency ferrite-core-free power transfer link which includes a scalable coil-array power transmitter floor and a single-coil implanted or worn power receiver. A specific design example is presented that includes the concept of low-SAR cellular single-transmitter-coil powering through dynamic tracking of a magnet-less receiver spatial location. The transmitter coil instantaneous supply current is monitored using a small number of low-cost electronic components. A drop in its value indicates the proximity of the receiver due to the reflected impedance of the latter. Only the transmitter coil nearest to the receiver is activated. Operating at the low frequency of 1.5 MHz, the inductive powering floor delivers a maximum of 15.9 W below the IEEE C95 SAR limit, which is over three times greater than that in other recently reported designs. The power transfer efficiency of 39% and 13% at the nominal and maximum distances of 8 cm and 11 cm, respectively, is maintained.

  9. Cacti beginner's guide leverage Cacti to design a robust network operations center

    CERN Document Server

    Urban, Thomas

    2017-01-01

    The book is designed in such a way that you can explore it chapter-by-chapter or skip any chapter without missing a beat. If you are a network operator and want to use Cacti for implementing performance measurement for trending, troubleshooting, and reporting purposes, then this book is for you. You only need to know the basics of network ...

  10. Technology for curriculum and teacher development : Software to help educators learn while designing teacher guides

    NARCIS (Netherlands)

    McKenney, Susan

    2005-01-01

    This article describes research on the quality of a computer program designed to help secondary level science teachers in southern Africa create exemplary paper-based lesson materials. Results of this study show that the content, support, and interface of the program combine to form a tool that is

  11. Guided design of heating and cooling mains for lower water and energy consumption and increased efficiency

    CSIR Research Space (South Africa)

    Gololo, V

    2011-01-01

    Full Text Available Water cooling and water heating is an important source of energy consumption, accounting for more than 20% of all energy consumption in manufacturing industry. It is clear that the development of heat recycling schemes and better structural design...

  12. Technical Support Document: Development of the Advanced Energy Design Guide for Medium to Big Box Retail Buildings - 50% Energy Savings

    Energy Technology Data Exchange (ETDEWEB)

    Bonnema, Eric [National Renewable Energy Lab. (NREL), Golden, CO (United States); Leach, Matt [National Renewable Energy Lab. (NREL), Golden, CO (United States); Pless, Shanti [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2013-06-05

    This Technical Support Document describes the process and methodology for the development of the Advanced Energy Design Guide for Medium to Big Box Retail Buildings: Achieving 50% Energy Savings Toward a Net Zero Energy Building (AEDG-MBBR) ASHRAE et al. (2011b). The AEDG-MBBR is intended to provide recommendations for achieving 50% whole-building energy savings in retail stores over levels achieved by following ANSI/ASHRAE/IESNA Standard 90.1-2004, Energy Standard for Buildings Except Low-Rise Residential Buildings (Standard 90.1-2004) (ASHRAE 2004b). The AEDG-MBBR was developed in collaboration with the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE), the American Institute of Architects (AIA), the Illuminating Engineering Society of North America (IES), the U.S. Green Building Council (USGBC), and the U.S. Department of Energy.

  13. Technical Support Document: Development of the Advanced Energy Design Guide for Medium to Big Box Retail Buildings - 50% Energy Savings

    Energy Technology Data Exchange (ETDEWEB)

    Bonnema, E.; Leach, M.; Pless, S.

    2013-06-01

    This Technical Support Document describes the process and methodology for the development of the Advanced Energy Design Guide for Medium to Big Box Retail Buildings: Achieving 50% Energy Savings Toward a Net Zero Energy Building (AEDG-MBBR) ASHRAE et al. (2011b). The AEDG-MBBR is intended to provide recommendations for achieving 50% whole-building energy savings in retail stores over levels achieved by following ANSI/ASHRAE/IESNA Standard 90.1-2004, Energy Standard for Buildings Except Low-Rise Residential Buildings (Standard 90.1-2004) (ASHRAE 2004b). The AEDG-MBBR was developed in collaboration with the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE), the American Institute of Architects (AIA), the Illuminating Engineering Society of North America (IES), the U.S. Green Building Council (USGBC), and the U.S. Department of Energy.

  14. Simulating future uncertainty to guide the selection of survey designs for long-term monitoring

    Science.gov (United States)

    Garman, Steven L.; Schweiger, E. William; Manier, Daniel J.; Gitzen, Robert A.; Millspaugh, Joshua J.; Cooper, Andrew B.; Licht, Daniel S.

    2012-01-01

    A goal of environmental monitoring is to provide sound information on the status and trends of natural resources (Messer et al. 1991, Theobald et al. 2007, Fancy et al. 2009). When monitoring observations are acquired by measuring a subset of the population of interest, probability sampling as part of a well-constructed survey design provides the most reliable and legally defensible approach to achieve this goal (Cochran 1977, Olsen et al. 1999, Schreuder et al. 2004; see Chapters 2, 5, 6, 7). Previous works have described the fundamentals of sample surveys (e.g. Hansen et al. 1953, Kish 1965). Interest in survey designs and monitoring over the past 15 years has led to extensive evaluations and new developments of sample selection methods (Stevens and Olsen 2004), of strategies for allocating sample units in space and time (Urquhart et al. 1993, Overton and Stehman 1996, Urquhart and Kincaid 1999), and of estimation (Lesser and Overton 1994, Overton and Stehman 1995) and variance properties (Larsen et al. 1995, Stevens and Olsen 2003) of survey designs. Carefully planned, “scientific” (Chapter 5) survey designs have become a standard in contemporary monitoring of natural resources. Based on our experience with the long-term monitoring program of the US National Park Service (NPS; Fancy et al. 2009; Chapters 16, 22), operational survey designs tend to be selected using the following procedures. For a monitoring indicator (i.e. variable or response), a minimum detectable trend requirement is specified, based on the minimum level of change that would result in meaningful change (e.g. degradation). A probability of detecting this trend (statistical power) and an acceptable level of uncertainty (Type I error; see Chapter 2) within a specified time frame (e.g. 10 years) are specified to ensure timely detection. Explicit statements of the minimum detectable trend, the time frame for detecting the minimum trend, power, and acceptable probability of Type I error (

  15. Comparing the catch composition, profitability and discard survival from different trammel net designs targeting common spiny lobster (Palinurus elephas) in a Mediterranean fishery.

    Science.gov (United States)

    Catanese, Gaetano; Hinz, Hilmar; Gil, Maria Del Mar; Palmer, Miquel; Breen, Michael; Mira, Antoni; Pastor, Elena; Grau, Amalia; Campos-Candela, Andrea; Koleva, Elka; Grau, Antoni Maria; Morales-Nin, Beatriz

    2018-01-01

    In the Balearic Islands, different trammel net designs have been adopted to promote fisheries sustainability and reduce discards. Here, we compare the catch performance of three trammel net designs targeting the spiny lobster Palinurus elephas in terms of biomass, species composition and revenue from commercial catches and discards. Designs differ in the netting fiber type (standard polyfilament, PMF, or a new polyethylene multi-monofilament, MMF) and the use of a guarding net or greca , a mesh piece intended to reduce discards. Catches were surveyed by an on-board observer from 1,550 netting walls corresponding to 70 nets. The number of marketable species captured indicated that the lobster trammel net fishery has multiple targets, which contribute significantly to the total revenue. The discarded species ranged from habitat-forming species to elasmobranches, but the magnitude of gear-habitat interactions on the long term dynamics of benthos remains unclear. No relevant differences in revenue and weight of discards were detected after Bayesian analyses. However, the species composition of discards was different when using greca . Interestingly, high immediate survival was found for discarded undersized lobsters, while a seven day survival assessment, using captive observation, gave an asymptotic estimate of survival probability as 0.64 (95% CI [0.54-0.76]). Therefore, it is recommended that it would be beneficial for this stock if an exemption from the EU landing obligation regulation was sought for undersized lobsters in the Balearic trammel net fishery.

  16. Comparing the catch composition, profitability and discard survival from different trammel net designs targeting common spiny lobster (Palinurus elephas in a Mediterranean fishery

    Directory of Open Access Journals (Sweden)

    Gaetano Catanese

    2018-05-01

    Full Text Available In the Balearic Islands, different trammel net designs have been adopted to promote fisheries sustainability and reduce discards. Here, we compare the catch performance of three trammel net designs targeting the spiny lobster Palinurus elephas in terms of biomass, species composition and revenue from commercial catches and discards. Designs differ in the netting fiber type (standard polyfilament, PMF, or a new polyethylene multi-monofilament, MMF and the use of a guarding net or greca, a mesh piece intended to reduce discards. Catches were surveyed by an on-board observer from 1,550 netting walls corresponding to 70 nets. The number of marketable species captured indicated that the lobster trammel net fishery has multiple targets, which contribute significantly to the total revenue. The discarded species ranged from habitat-forming species to elasmobranches, but the magnitude of gear-habitat interactions on the long term dynamics of benthos remains unclear. No relevant differences in revenue and weight of discards were detected after Bayesian analyses. However, the species composition of discards was different when using greca. Interestingly, high immediate survival was found for discarded undersized lobsters, while a seven day survival assessment, using captive observation, gave an asymptotic estimate of survival probability as 0.64 (95% CI [0.54–0.76]. Therefore, it is recommended that it would be beneficial for this stock if an exemption from the EU landing obligation regulation was sought for undersized lobsters in the Balearic trammel net fishery.

  17. The design, simulation and testing of an urban vertical axis wind turbine with the omni-direction-guide-vane

    International Nuclear Information System (INIS)

    Chong, W.T.; Fazlizan, A.; Poh, S.C.; Pan, K.C.; Hew, W.P.; Hsiao, F.B.

    2013-01-01

    Graphical abstract: Solar energy, renewable energy, urban wind energy, environment, augmented wind turbine. Highlights: ► A system for on-site wind–solar hybrid power generation and rain water collection. ► The omni-direction-guide-vane (ODGV) overcomes the weak wind and turbulence conditions in urban areas. ► The ODGV improves the wind turbine performance by speeding-up and guiding the wind. ► The ODGV is designed to blend into the building architecture with safety enhancement. ► The wind tunnel test and CFD simulation results are presented. - Abstract: A novel omni-direction-guide-vane (ODGV) that surrounds a vertical axis wind turbine (VAWT) is designed to improve the wind turbine performance. Wind tunnel testing was performed to evaluate the performance of a 5-bladed (Wortmann FX63-137 airfoil) H-rotor wind turbine, with and without the integration of the ODGV. The test was conducted using a scaled model turbine which was constructed to simulate the VAWT enclosed by the ODGV placed on a building. The VAWT shows an improvement on its self-starting behavior where the cut-in speed was reduced with the integration of the ODGV. Since the VAWT is able to self-start at a lower wind speed, the working hour of the wind turbine would increase. At a wind speed of 6 m/s and under free-running condition (only rotor inertia and bearing friction were applied), the ODGV helps to increase the rotor rotational speed by 182%. With extra load application at the same wind speed (6 m/s), the wind turbine power output was increased by 3.48 times at its peak torque with the aid of the ODGV. The working concept of the ODGV is to minimize the negative torque zone of a lift-type VAWT and to reduce turbulence and rotational speed fluctuation. It was verified by re-simulating the torque coefficient data of a single bladed (NACA 0015 airfoil) VAWT published by the Sandia National Laboratories. From the simulation results, with the presence of the ODGV, it was shown that the

  18. An innovative design for using flexible printed coils for magnetostrictive-based longitudinal guided wave sensors in steel strand inspection

    International Nuclear Information System (INIS)

    Tse, P W; Liu, X C; Wang, X J; Liu, Z H; Wu, B; He, C F

    2011-01-01

    Magnetostrictive sensors (MsSs) that can excite and receive guided waves are commonly used in detecting defects that may occur in cables and strands for supporting heavy structures. A conventional MsS has a hard sensing coil that is wound onto a bobbin with electric wires to generate the necessary dynamic magnetic field to excite the desired guided waves. This tailor-made hard coil is usually bulky and is not flexible enough to fit steel strands of various sizes. The conventional MsS also cannot be mounted to any steel strand that does not have a free end to allow the bobbin to pass through the structure of the tested strand. Such inflexibilities limit the use of conventional MsSs in practical situations. To solve these limitations, an innovative type of coil, called a flexible printed coil (FPC), which is made out of flexible printed film, has been designed to replace the inflexible hard coil. The flexible structure of the FPC ensures that the new MsS can be easily installed on and removed from steel strands with different diameters and without free ends. Moreover, the FPC-based MsS can be wrapped into multiple layers due to its thin and flexible design. Although multi-layer FPC creates a minor asymmetry in the dynamic magnetic field, the results of finite element analysis and experiments confirm that the longitudinal guided waves excited by a FPC-based MsS are comparable to those excited by a conventional hard coil MsS. No significant reduction in defect inspection performance was found; in fact, further advantages were identified when using the FPC-based MsS. When acting as the transmitter, the innovative FPC-based MsS can cover a longer inspection length of strand. When acting as the receiver, the FPC-based MsS is more sensitive to smaller defects that are impossible to detect using a hard coil MsS. Hence, the multi-layer FPC-based MsS has great potential for replacing the conventional hard coil MsS because of its convenient installation, and ease of fitting to

  19. The linear shade guide design of Vita 3D-master performs as well as the original design of the Vita 3D-master.

    Science.gov (United States)

    Corcodel, N; Rammelsberg, P; Jakstat, H; Moldovan, O; Schwarz, S; Hassel, A J

    2010-11-01

    Visual tooth colour assessment by use of the Vita 3D-Master(®) (3D; Vita Zahnfabrik, Bad Säckingen, Germany) is well documented. To improve handling, a new linear arrangement of the shade tabs has been introduced (LG; Linearguide 3D-Master(®) ). The purpose of this study was to investigate whether the linear design has an effect on shade matching. Fifty-six students underwent identical, theoretical and practical training, by use of an Internet learning module [Toothguide Training Software(®) (TT)] and a standardised training programme [Toothguide Training Box(®) (TTB)]. Each student then matched 30 randomly chosen shade tabs presented in an intra-oral setting by a standardised device [Toothguide Check Box(®) (TCB)]; 15 matches were made using the 3D and 15 using the LG shade guide system, under a daylight lamp (840 matches for each guide). It was recorded to what extent the presented and selected shade tabs, or the lightness group of the tabs, matched, also the needed time for colour matching. The results showed that 35% of perfect matches were observed for the 3D and 32% for the LG. The lightness group was correct in 59% of cases for 3D and 56% for LG. Mean time needed for matching of tabs and lightness group was no different between groups (no significant difference for any assessment). Within the limitations of the study design, the colour assessment with regard to performance and time needed in shade matching was not different with the LG or the 3D. Therefore, the user should choose which shade tab arrangement is more applicable. © 2010 Blackwell Publishing Ltd.

  20. Mobile Tourism Guide in the Context of Thai National Parks: The Effects of Mobile Design Qualities in TAM2

    Directory of Open Access Journals (Sweden)

    Trakulmaykee Numtip

    2014-01-01

    Full Text Available This study aims to predict the level of international tourists’ intention to use MTG in the context of Thai national parks, and investigates the roles of mobile design qualities (content quality, appearance quality, and interaction quality through perceived usefulness and perceived ease-of-use on intention. The mixed-method via exploratory sequential design is conducted this study. The qualitative approach is started in the first stage then quantitative approach is employed to analyze the large sample size. This study extends the TAM2 with mobile design qualities. The results shows the high level of international tourist’ intention to use MTG. It indicates that the international tourists will intent to the mobile tourism guide (MTG, if the MTG is provided for them. The direct factors of tourists’ intention are perceived usefulness, perceived ease-of-use, mobile content quality and mobile appearance quality. The most direct effect is mobile content quality. The qualities of content and appearance have the positive roles on perceived usefulness, while the qualities of appearance and interaction have the indirect effects through perceived ease-of-use on tourists’ intention. The proposed model provides the body of knowledge in the context of MTG, especially the factors of international tourists’ intention to use MTG.

  1. Transcranial Direct Current Stimulation (tDCS: A Beginner's Guide for Design and Implementation

    Directory of Open Access Journals (Sweden)

    Hayley Thair

    2017-11-01

    Full Text Available Transcranial direct current stimulation (tDCS is a popular brain stimulation method that is used to modulate cortical excitability, producing facilitatory or inhibitory effects upon a variety of behaviors. There is, however, a current lack of consensus between studies, with many results suggesting that polarity-specific effects are difficult to obtain. This article explores some of these differences and highlights the experimental parameters that may underlie their occurrence. We provide a general, practical snapshot of tDCS methodology, including what it is used for, how to use it, and considerations for designing an effective and safe experiment. Our aim is to equip researchers who are new to tDCS with the essential knowledge so that they can make informed and well-rounded decisions when designing and running successful experiments. By summarizing the varied approaches, stimulation parameters, and outcomes, this article should help inform future tDCS research in a variety of fields.

  2. Transcranial Direct Current Stimulation (tDCS): A Beginner's Guide for Design and Implementation

    Science.gov (United States)

    Thair, Hayley; Holloway, Amy L.; Newport, Roger; Smith, Alastair D.

    2017-01-01

    Transcranial direct current stimulation (tDCS) is a popular brain stimulation method that is used to modulate cortical excitability, producing facilitatory or inhibitory effects upon a variety of behaviors. There is, however, a current lack of consensus between studies, with many results suggesting that polarity-specific effects are difficult to obtain. This article explores some of these differences and highlights the experimental parameters that may underlie their occurrence. We provide a general, practical snapshot of tDCS methodology, including what it is used for, how to use it, and considerations for designing an effective and safe experiment. Our aim is to equip researchers who are new to tDCS with the essential knowledge so that they can make informed and well-rounded decisions when designing and running successful experiments. By summarizing the varied approaches, stimulation parameters, and outcomes, this article should help inform future tDCS research in a variety of fields. PMID:29213226

  3. Increased performance in a bottom-up designed robot by experimentally guided redesign

    DEFF Research Database (Denmark)

    Larsen, Jørgen Christian

    2013-01-01

    Purpose – Using a bottom-up, model-free approach when building robots is often seen as a less scientific way, compared to a top-down model-based approach, because the results are not easily generalizable to other systems. The authors, however, hypothesize that this problem may be addressed by using...... the bottom-up, mode-free approach, the authors used the robotic construction kit, LocoKit. This construction kit allows researchers to construct legged robots, without having a mathematical model beforehand. The authors used no specific mathematical model to design the robot, but instead used intuition...... solid experimental methods. The purpose of this paper is to show how well-known experimental methods from bio-mechanics are used to measure and locate weaknesses in a bottom-up, model-free implementation of a quadruped walker and come up with a better solution. Design/methodology/approach – To study...

  4. Building a Roll-Off Roof Observatory A Complete Guide for Design and Construction

    CERN Document Server

    Hicks, John

    2009-01-01

    Almost every practical astronomer who takes the pursuit to its second level aspires to a fixed, permanent housing for his telescope, permitting its rapid and comfortable use and avoiding hours of setting-up time for each observing session. A roll-off roof observatory is the simplest and by far the most popular observatory design for today’s practical astronomers. Building a Roll-off Roof Observatory will help you decide whether to embark on the venture and will certainly provoke your enthusiasm for the project. The author, both an amateur astronomer and professional landscape architect, answers many of the common questions asked around observatory construction covering the following topics: Site planning, zoning, and by-law requirements common to most states, towns and municipalities Opportunities for locating the observatory Tailoring the observatory for your particular use Tools and structural components required to build it Variations in footing design to suit your soil conditions Variations possible in ...

  5. NMR screening in fragment-based drug design: a practical guide.

    Science.gov (United States)

    Kim, Hai-Young; Wyss, Daniel F

    2015-01-01

    Fragment-based drug design (FBDD) comprises both fragment-based screening (FBS) to find hits and elaboration of these hits to lead compounds. Typical fragment hits have lower molecular weight (FBDD since it identifies and localizes the binding site of weakly interacting hits on the target protein. Here we describe ligand-based NMR methods for hit identification from fragment libraries and for functional cross-validation of primary hits.

  6. Theory and simulation of DNA-coated colloids: a guide for rational design.

    Science.gov (United States)

    Angioletti-Uberti, Stefano; Mognetti, Bortolo M; Frenkel, Daan

    2016-03-07

    By exploiting the exquisite selectivity of DNA hybridization, DNA-coated colloids (DNACCs) can be made to self-assemble in a wide variety of structures. The beauty of this system stems largely from its exceptional versatility and from the fact that a proper choice of the grafted DNA sequences yields fine control over the colloidal interactions. Theory and simulations have an important role to play in the optimal design of self assembling DNACCs. At present, the powerful model-based design tools are not widely used, because the theoretical literature is fragmented and the connection between different theories is often not evident. In this Perspective, we aim to discuss the similarities and differences between the different models that have been described in the literature, their underlying assumptions, their strengths and their weaknesses. Using the tools described in the present Review, it should be possible to move towards a more rational design of novel self-assembling structures of DNACCs and, more generally, of systems where ligand-receptor are used to control interactions.

  7. The influence of design characteristics on statistical inference in nonlinear estimation: A simulation study based on survival data and hazard modeling

    DEFF Research Database (Denmark)

    Andersen, J.S.; Bedaux, J.J.M.; Kooijman, S.A.L.M.

    2000-01-01

    This paper describes the influence of design characteristics on the statistical inference for an ecotoxicological hazard-based model using simulated survival data. The design characteristics of interest are the number and spacing of observations (counts) in time, the number and spacing of exposure...... concentrations (within c(min) and c(max)), and the initial number of individuals at time 0 in each concentration. A comparison of the coverage probabilities for confidence limits arising from the profile-likelihood approach and the Wald-based approach is carried out. The Wald-based approach is very sensitive...

  8. Network survivability performance

    Science.gov (United States)

    1993-11-01

    This technical report has been developed to address the survivability of telecommunications networks including services. It responds to the need for a common understanding of, and assessment techniques for network survivability, availability, integrity, and reliability. It provides a basis for designing and operating telecommunications networks to user expectations for network survivability and a foundation for continuing industry activities in the subject area. This report focuses on the survivability of both public and private networks and covers a wide range of users. Two frameworks are established for quantifying and categorizing service outages, and for classifying network survivability techniques and measures. The performance of the network survivability techniques is considered; however, recommended objectives are not established for network survivability performance.

  9. Computer-Aided Design/Computer-Assisted Manufacture-Derived Needle Guide for Injection of Botulinum Toxin into the Lateral Pterygoid Muscle in Patients with Oromandibular Dystonia.

    Science.gov (United States)

    Yoshida, Kazuya

    2018-01-01

    To evaluate the effectiveness and safety of botulinum toxin administration into the inferior head of the lateral pterygoid muscle of patients with jaw opening dystonia by using a computer-aided design/computer-assisted manufacture (CAD/CAM)-derived needle guide. A total of 17 patients with jaw opening dystonia were enrolled. After the patient's computed tomography (CT) scan was imported and fused with a scan of a plaster cast model of the maxilla, the optimal needle insertion site over the lateral pterygoid muscle was determined using the NobelClinician software. A total of 13 patients were injected both with and without the guide, and 4 patients underwent guided injection alone. The therapeutic effects of botulinum toxin injection and its associated complications were statistically compared between the guided and unguided procedures using paired t test. Botulinum toxin therapy was performed 42 and 32 times with and without the guides, respectively. The needle was easily inserted without any complications in all procedures. There was a significant difference (P < .001) between the mean comprehensive improvements observed with (66.3%) and without (54.4%) the guides. The findings suggest that the use of needle guides during the injection of botulinum toxin into the inferior head of the lateral pterygoid muscle is very useful for aiding the accurate and safe administration of botulinum toxin therapy for jaw opening dystonia.

  10. Guide to beamline radiation shielding design at the Advanced Photon Source

    International Nuclear Information System (INIS)

    Ipe, N.; Haeffner, D.R.; Alp, E.E.; Davey, S.C.; Dejus, R.J.; Hahn, U.; Lai, B.; Randall, K.J.; Shu, D.

    1993-11-01

    This document is concerned with the general requirements for radiation shielding common to most Advanced Photon Source (APS) users. These include shielding specifications for hutches, transport, stops, and shutters for both white and monochromatic beams. For brevity, only the results of calculations are given in most cases. So-called open-quotes special situationsclose quotes are not covered. These include beamlines with white beam mirrors for low-pass energy filters (open-quotes pink beamsclose quotes), extremely wide band-pass monochromators (multilayers), or novel insertion devices. These topics are dependent on beamline layout and, as such, are not easily generalized. Also, many examples are given for open-quotes typicalclose quotes hutches or other beamline components. If a user has components that differ greatly from those described, particular care should be taken in following these guidelines. Users with questions on specific special situations should address them to the APS User Technical Interface. Also, this document does not cover specifics on hutch, transport, shutter, and stop designs. Issues such as how to join hutch panels, floor-wall interfaces, cable feed-throughs, and how to integrate shielding into transport are covered in the APS Beamline Standard Components Handbook. It is a open-quotes living documentclose quotes and as such reflects the improvements in component design that are ongoing. This document has the following content. First, the design criteria will be given. This includes descriptions of some of the pertinent DOE regulations and policies, as well as brief discussions of abnormal situations, interlocks, local shielding, and storage ring parameters. Then, the various sources of radiation on the experimental floor are discussed, and the methods used to calculate the shielding are explained (along with some sample calculations). Finally, the shielding recommendations for different situations are given and discussed

  11. A Guide to Visual Multi-Level Interface Design From Synthesis of Empirical Study Evidence

    CERN Document Server

    Lam, Heidi

    2010-01-01

    Displaying multiple levels of data visually has been proposed to address the challenge of limited screen space. Although many previous empirical studies have addressed different aspects of this question, the information visualization research community does not currently have a clearly articulated consensus on how, when, or even if displaying data at multiple levels is effective. To shed more light on this complex topic, we conducted a systematic review of 22 existing multi-level interface studies to extract high-level design guidelines. To facilitate discussion, we cast our analysis findings

  12. SYNCH: A program for design and analysis of synchrotrons and beamlines -- user`s guide

    Energy Technology Data Exchange (ETDEWEB)

    Garren, A.A.; Kenney, A.S.; Courant, E.D.; Russell, A.D.; Syphers, M.J.

    1993-12-31

    SYNCH is a computer program for use in the design and analysis of synchrotrons, storage rings, and beamlines. It has a large repertoire of commands that can be accessed in a flexible way. The input statements and the results of the calculations they invoke are saved in an internal database so that this information may be shared by other statements. SYNCH is the first accelerator program to organize its input in the form of a language. The statements, which resemble sentences, provide a natural way of describing lattices and invoking relevant calculations. The organization of the program is modular, so that it has been possible to expand its capabilities progressively.

  13. Designing control loops for linear and switching power supplies a tutorial guide

    CERN Document Server

    Basso, Christophe P

    2012-01-01

    Loop control is an essential area of electronics engineering that today's professionals need to master. Rather than delving into extensive theory, this practical book focuses on what you really need to know for compensating or stabilizing a given control system. You can turn instantly to practical sections with numerous design examples and ready-made formulas to help you with your projects in the field. You also find coverage of the underpinnings and principles of control loops so you can gain a more complete understanding of the material. This authoritative volume explains how to conduct anal

  14. User’s Guide: Computer Program for Design or Investigation of Orthogonal Culverts (CORTCUL).

    Science.gov (United States)

    1981-03-01

    This report is divided into the following parts: a. Part II describes the general culvert and soil system to be designed or investigated by the...Note that cover dimensions do not affect internal forces calculated by the program. 119. Attention is directed to the reinfor-t ismnt informat ion j...h iug the distribution of special loads. T. ft Waiter Loads a..’ia I water loads are permitted only i n the I NV11S’l IGATIN mode wi th Stanidard

  15. Curves and surfaces for computer-aided geometric design a practical guide

    CERN Document Server

    Farin, Gerald

    1992-01-01

    A leading expert in CAGD, Gerald Farin covers the representation, manipulation, and evaluation of geometric shapes in this the Third Edition of Curves and Surfaces for Computer Aided Geometric Design. The book offers an introduction to the field that emphasizes Bernstein-Bezier methods and presents subjects in an informal, readable style, making this an ideal text for an introductory course at the advanced undergraduate or graduate level.The Third Edition includes a new chapter on Topology, offers new exercises and sections within most chapters, combines the material on Geometric Continuity i

  16. 3D computations of flow field in a guide vane blading designed by means of 2D model for a low head hydraulic turbine

    International Nuclear Information System (INIS)

    Krzemianowski, Z; Puzyrewski, R

    2014-01-01

    The paper presents the main parameters of the flow field behind the guide vane cascade designed by means of 2D inverse problem and following check by means of 3D commercial program ANSYS/Fluent applied for a direct problem. This approach of using different models reflects the contemporary design procedure for non-standardized turbomachinery stage. Depending on the model, the set of conservation equation to be solved differs, although the physical background remains the same. The example of computations for guide vane cascade for a low head hydraulic turbine is presented.

  17. Building a roll-off roof or dome observatory a complete guide for design and construction

    CERN Document Server

    Hicks, John Stephen

    2016-01-01

    Almost every practical astronomer eventually aspires to have a fixed, permanent observatory for his or her telescope. A roll-off roof or dome observatory is the answer for the most popular home observatory design.  Almost every practical astronomer eventually aspires to have a fixed, permanent observatory for his or her telescope. A roll-off roof or dome observatory is the answer for the most popular home observatory design. Building a Roll-Off or Dome Observatory will help you decide whether to embark on the venture and will certainly increase your enthusiasm for the project. The author, both an amateur astronomer and a professional landscape architect, answers many of the common questions asked about observatory construction, covering the following topics: • Zoning, and by-law requirements common to most states, towns and municipalities • Where to locate the observatory • How to tailor the observatory for your particular needs • Tools and structural components required • Possible variations in de...

  18. Secondary Maxillary and Orbital Floor Reconstruction With a Free Scapular Flap Using Cutting and Fixation Guides Created by Computer-Aided Design/Computer-Aided Manufacturing.

    Science.gov (United States)

    Morita, Daiki; Numajiri, Toshiaki; Tsujiko, Shoko; Nakamura, Hiroko; Yamochi, Ryo; Sowa, Yoshihiro; Yasuda, Makoto; Hirano, Shigeru

    2017-11-01

    Computer-aided design/computer-aided manufacturing (CAD/CAM) guides are now widely used in maxillofacial reconstruction. However, there are few reports of CAD/CAM guides being used for scapular flaps. The authors performed the secondary maxillary and orbital floor reconstruction using a free latissimus dorsi muscle, cutaneous tissue, and scapular flap designed using CAD/CAM techniques in a 72-year-old man who had undergone partial maxillectomy four years previously. The patient had diplopia, the vertical dystopia of eye position, and a large oral-nasal-cutaneous fistula. After the operation, the authors confirmed that the deviation between the postoperative and preoperative planning three-dimensional images was less than 2 mm. Because scapular guides require 3 cutting surfaces, the shape of the scapular guide is more complex than that of a conventional fibular guide. In orbital floor reconstruction, the use of a CAM technique such as that used to manufacture the authors' fixation guide is as necessary for accurate, safe, and easy reconstruction as is preoperative CAD planning. The production of a fixation guide as well as a cutting guide is particularly useful because it is difficult to determine the angle for reconstructing the orbital floor by freehand techniques. In this case, the orbital floor was reconstructed based on a mirror image of the healthy side to avoid overcompression of the orbital tissue. Although the patient's vertical dystopia of eye position was improved, diplopia was not improved because, for greater safety, the authors did not plan overcorrection of the orbital volume.

  19. Launch and Functional Considerations Guiding the Scaling and Design of Rigid Inflatable Habitat Modules

    Science.gov (United States)

    Bell, L.

    2002-01-01

    The Sasakawa International Center for Space Architecture (SICSA) has a long history of projects that involve design of space structures, including habitats for low-Earth orbit (LEO) and planetary applications. Most of these facilities and component systems are planned to comply with size, geometry and mass restrictions imposed by the Space Shuttle Orbiter's payload and lift/landing abort restrictions. These constraints limit launch elements to approximately 15 ft. diameter, 40 ft. long cylindrical dimensions weighing no more than approximately 25 metric tons. It is clear that future success of commercial space programs such as tourism will hinge upon the availability of bigger and more efficient Earth to LEO launch vehicles which can greatly reduce transportation and operational costs. This will enable development and utilization of larger habitat modules and other infrastructure elements which can be deployed with fewer launches and on-orbit assembly procedures. The sizing of these new heavy lift launchers should be scaled to optimize habitat functionality and efficiency, just as the habitat designs must consider optimization of launch vehicle economy. SICSA's planning studies address these vehicle and habitat optimization priorities as parallel and interdependent considerations. The allowable diameter of habitat modules established by launch vehicle capacity dictates functionally acceptable internal configuration options. Analyses of these options relative to practical dimensions for Earth-to-orbit launch vehicle scaling were conducted for two general schemes. The "bologna slice" configuration stacks the floors within a predominately cylindrical or spherical envelope, producing circular areas. The "banana split" approach divides a cylindrical module longitudinally, creating floors that are generally rectangular in shape. The assessments established minimum sizes for reasonable utility and efficiency. The bologna slice option. This configuration is only acceptable

  20. Corrosion test plan to guide canister material selection and design for a tuff repository

    International Nuclear Information System (INIS)

    McCright, R.D.; van Konynenburg, R.A.; Ballou, L.B.

    1983-11-01

    Corrosion rates and the mode of corrosion attack form a most important basis for selection of canister materials and design of a nuclear waste package. Type 304L stainless steel was selected as the reference material for canister fabrication because of its generally excellent corrosion resistance in water, steam and air. However, 304L may be susceptible to localized and stress-assisted forms of corrosion under certain conditions. Alternative alloys are also investigated; these alloys were chosen because of their improved resistance to these forms of corrosion. The fabrication and welding processes, as well as the glass pouring operation for defense and commercial high-level wastes, may influence the susceptibility of the canister to localized and stress forms of corrosion. 12 references, 2 figures, 4 tables

  1. Visualize This The FlowingData Guide to Design, Visualization, and Statistics

    CERN Document Server

    Yau, Nathan

    2011-01-01

    Practical data design tips from a data visualization expert of the modern age Data doesn?t decrease; it is ever-increasing and can be overwhelming to organize in a way that makes sense to its intended audience. Wouldn?t it be wonderful if we could actually visualize data in such a way that we could maximize its potential and tell a story in a clear, concise manner? Thanks to the creative genius of Nathan Yau, we can. With this full-color book, data visualization guru and author Nathan Yau uses step-by-step tutorials to show you how to visualize and tell stories with data. He explains how to ga

  2. A practical guide to the design and construction of a single wire beverage antenna

    Science.gov (United States)

    Spong, H. L.

    1980-09-01

    Theoretical results are presented which show the performance likely to result from using differing antenna heights, lengths and wire sizes and from operating with different ground conductivities. These studies were undertaken to provide practical advice for constructors and operators. Design parameters can be easily obtained with the aid of computer programs and an antenna can be rapidly constructed from readily available materials. Directivity can be increased by adding more elements, either in parallel or on a radial basis. A particular performance can be achieved with great latitude in the parameters. Good low angle performance can be achieved without large ground screens. A directional array can be made by switching between a number of elements set up on different bearings.

  3. Genome-scale model guided design of Propionibacterium for enhanced propionic acid production.

    Science.gov (United States)

    Navone, Laura; McCubbin, Tim; Gonzalez-Garcia, Ricardo A; Nielsen, Lars K; Marcellin, Esteban

    2018-06-01

    Production of propionic acid by fermentation of propionibacteria has gained increasing attention in the past few years. However, biomanufacturing of propionic acid cannot compete with the current oxo-petrochemical synthesis process due to its well-established infrastructure, low oil prices and the high downstream purification costs of microbial production. Strain improvement to increase propionic acid yield is the best alternative to reduce downstream purification costs. The recent generation of genome-scale models for a number of Propionibacterium species facilitates the rational design of metabolic engineering strategies and provides a new opportunity to explore the metabolic potential of the Wood-Werkman cycle. Previous strategies for strain improvement have individually targeted acid tolerance, rate of propionate production or minimisation of by-products. Here we used the P. freudenreichii subsp . shermanii and the pan- Propionibacterium genome-scale metabolic models (GEMs) to simultaneously target these combined issues. This was achieved by focussing on strategies which yield higher energies and directly suppress acetate formation. Using P. freudenreichii subsp . shermanii , two strategies were assessed. The first tested the ability to manipulate the redox balance to favour propionate production by over-expressing the first two enzymes of the pentose-phosphate pathway (PPP), Zwf (glucose-6-phosphate 1-dehydrogenase) and Pgl (6-phosphogluconolactonase). Results showed a 4-fold increase in propionate to acetate ratio during the exponential growth phase. Secondly, the ability to enhance the energy yield from propionate production by over-expressing an ATP-dependent phosphoenolpyruvate carboxykinase (PEPCK) and sodium-pumping methylmalonyl-CoA decarboxylase (MMD) was tested, which extended the exponential growth phase. Together, these strategies demonstrate that in silico design strategies are predictive and can be used to reduce by-product formation in

  4. Genome-scale model guided design of Propionibacterium for enhanced propionic acid production

    Directory of Open Access Journals (Sweden)

    Laura Navone

    2018-06-01

    Full Text Available Production of propionic acid by fermentation of propionibacteria has gained increasing attention in the past few years. However, biomanufacturing of propionic acid cannot compete with the current oxo-petrochemical synthesis process due to its well-established infrastructure, low oil prices and the high downstream purification costs of microbial production. Strain improvement to increase propionic acid yield is the best alternative to reduce downstream purification costs. The recent generation of genome-scale models for a number of Propionibacterium species facilitates the rational design of metabolic engineering strategies and provides a new opportunity to explore the metabolic potential of the Wood-Werkman cycle. Previous strategies for strain improvement have individually targeted acid tolerance, rate of propionate production or minimisation of by-products. Here we used the P. freudenreichii subsp. shermanii and the pan-Propionibacterium genome-scale metabolic models (GEMs to simultaneously target these combined issues. This was achieved by focussing on strategies which yield higher energies and directly suppress acetate formation. Using P. freudenreichii subsp. shermanii, two strategies were assessed. The first tested the ability to manipulate the redox balance to favour propionate production by over-expressing the first two enzymes of the pentose-phosphate pathway (PPP, Zwf (glucose-6-phosphate 1-dehydrogenase and Pgl (6-phosphogluconolactonase. Results showed a 4-fold increase in propionate to acetate ratio during the exponential growth phase. Secondly, the ability to enhance the energy yield from propionate production by over-expressing an ATP-dependent phosphoenolpyruvate carboxykinase (PEPCK and sodium-pumping methylmalonyl-CoA decarboxylase (MMD was tested, which extended the exponential growth phase. Together, these strategies demonstrate that in silico design strategies are predictive and can be used to reduce by-product formation in

  5. Guiding Design of University STEM Courses Based on Gifted Status and Strategies for Success

    Science.gov (United States)

    Hawthorne Allen, A. M.

    2016-12-01

    Starting from general population statistics and the self-selection of STEM majors by students, it can be concluded that science classes have a population of students trending towards the gifted, regardless of academic institution and admissions selectivity. On average, upper level and graduate STEM courses have an increasingly larger fraction of gifted students. I propose that the average level of giftedness of the students within a course serves as an overriding characteristic that is more significant than other demographic variables. Using this model when designing a STEM course can lead to more successful learning outcomes. In 1991, the Columbus Group defined giftedness as "asynchronous development in which advanced cognitive abilities and heightened intensity combine to create inner experiences and awareness than are qualitatively different from the norm." These gifted characteristics are fundamentally innate lifelong traits that persist beyond K-12 designations and into our college classrooms. As this broader understanding of giftedness has emerged, myths and stereotypes in prior literature have also become clearer. Understanding and naming these myths can better impact our teaching effectiveness. While the diversity of gifted populations makes generalization difficult, gifted individuals can be described as having the following: asynchronous development, increased perceptivity, high sensitivity, perfectionism, and intensity. Several levels of giftedness have been identified on the basis of IQ scores or innate characteristics from birth. In addition, students who are twice-exceptional are yet another subpopulation present in our classes. If the average gifted level of STEM majors is higher than the norm population for a typical level of education, then understanding the characteristics of the subpopulations and the impact on classroom dynamics is essential. This directly impacts our STEM teaching pedagogy and style if productive learning outcomes are to be

  6. Sensitivity of traffic input parameters on rutting performance of a flexible pavement using Mechanistic Empirical Pavement Design Guide

    Directory of Open Access Journals (Sweden)

    Nur Hossain

    2016-11-01

    Full Text Available The traffic input parameters in the Mechanistic Empirical Pavement Design Guide (MEPDG are: (a general traffic inputs, (b traffic volume adjustment factors, and (c axle load spectra (ALS. Of these three traffic inputs, the traffic volume adjustment factors specifically monthly adjustment factor (MAF and the ALS are widely considered to be important and sensitive factors, which can significantly affect design of and prediction of distress in flexible pavements. Therefore, the present study was undertaken to assess the sensitivity of ALS and MAF traffic inputs on rutting distress of a flexible pavement. The traffic data of four years (from 2008 to 2012 were collected from an instrumented test section on I-35 in Oklahoma. Site specific traffic input parameters were developed. It was observed that significant differences exist between the MEPDG default and developed site-specific traffic input values. However, the differences in the yearly ALS and MAF data, developed for these four years, were not found to be as significant when compared to one another. In addition, quarterly field rut data were measured on the test section and compared with the MEPDG predicted rut values using the default and developed traffic input values for different years. It was found that significant differences exist between the measured rut and the MEPDG (AASHTOWare-ME predicted rut when default values were used. Keywords: MEPDG, Rut, Level 1 inputs, Axle load spectra, Traffic input parameters, Sensitivity

  7. Pilot Study for OCT Guided Design and Fit of a Prosthetic Device for Treatment of Corneal Disease

    Directory of Open Access Journals (Sweden)

    Hong-Gam T. Le

    2012-01-01

    Full Text Available Purpose. To assess optical coherence tomography (OCT for guiding design and fit of a prosthetic device for corneal disease. Methods. A prototype time domain OCT scanner was used to image the anterior segment of patients fitted with large diameter (18.5–20 mm prosthetic devices for corneal disease. OCT images were processed and analyzed to characterize corneal diameter, corneal sagittal height, scleral sagittal height, scleral toricity, and alignment of device. Within-subject variance of OCT-measured parameters was evaluated. OCT-measured parameters were compared with device parameters for each eye fitted. OCT image correspondence with ocular alignment and clinical fit was assessed. Results. Six eyes in 5 patients were studied. OCT measurement of corneal diameter (coefficient of variation, %, cornea sagittal height (%, and scleral sagittal height (% is highly repeatable within each subject. OCT image-derived measurements reveal strong correlation between corneal sagittal height and device corneal height ( and modest correlation between scleral and on-eye device toricity (. Qualitative assessment of a fitted device on OCT montages reveals correspondence with slit lamp images and clinical assessment of fit. Conclusions. OCT imaging of the anterior segment is suitable for custom design and fit of large diameter (18.5–20 mm prosthetic devices used in the treatment of corneal disease.

  8. Numerical study on dissimilar guide vane design with SCC piston for air and emulsified biofuel mixing improvement

    Directory of Open Access Journals (Sweden)

    Hamid Mohd Fadzli

    2017-01-01

    Full Text Available Crude palm oil (CPO is one of the most potential biofuels that can be applied in the conventional diesel engines, where the chemical properties of CPO are comparable to diesel fuel. However, its higher viscosity and heavier molecules can contributes to several engine problems such as low atomization during injection, carbon deposit formation, injector clogging, low mixing with air and lower combustion efficiency. An emulsification of biofuel and modifications of few engine critical components have been identified to mitigate the issues. This paper presents the effects of dissimilar guide vane design (GVD in terms of height variation of 0.25R, 0.3R and 0.35R at the intake manifold with shallow depth re-entrance combustion chamber (SCC piston application to the incylinder air flow characteristics improvement. The simulation results show that the intake manifold with GVD improved the performance of the air flow characteristic particularly swirl, tumble and cross tumble ratios from the intake manifold to the engine. The GVD with the height of 0.3R was found to be the optimum design with respect to the overall improvement of the air flow characteristic. The improvement of the air flow characteristic with the application of GVD and SCC piston in the engine was expected to contribute to a better air fuel mixing, fuel atomization and combustion efficiency of the engine using emulsified biofuel as a source of fuel.

  9. Optical Design of COATLI: A Diffraction-Limited Visible Imager with Fast Guiding and Active Optics Correction

    Science.gov (United States)

    Fuentes-Fernández, J.; Cuevas, S.; Watson, A. M.

    2018-04-01

    We present the optical design of COATLI, a two channel visible imager for a comercial 50 cm robotic telescope. COATLI will deliver diffraction-limited images (approximately 0.3 arcsec FWHM) in the riz bands, inside a 4.2 arcmin field, and seeing limited images (approximately 0.6 arcsec FWHM) in the B and g bands, inside a 5 arcmin field, by means of a tip-tilt mirror for fast guiding, and a deformable mirror for active optics, both located on two optically transferred pupil planes. The optical design is based on two collimator-camera systems plus a pupil transfer relay, using achromatic doublets of CaF2 and S-FTM16 and one triplet of N-BK7 and CaF2. We discuss the effciency, tolerancing, thermal behavior and ghosts. COATLI will be installed at the Observatorio Astronómico Nacional in Sierra San Pedro Mártir, Baja California, Mexico, in 2018.

  10. A methodology to guide the selection of composite materials in a wind turbine rotor blade design process

    Science.gov (United States)

    Bortolotti, P.; Adolphs, G.; Bottasso, C. L.

    2016-09-01

    This work is concerned with the development of an optimization methodology for the composite materials used in wind turbine blades. Goal of the approach is to guide designers in the selection of the different materials of the blade, while providing indications to composite manufacturers on optimal trade-offs between mechanical properties and material costs. The method works by using a parametric material model, and including its free parameters amongst the design variables of a multi-disciplinary wind turbine optimization procedure. The proposed method is tested on the structural redesign of a conceptual 10 MW wind turbine blade, its spar caps and shell skin laminates being subjected to optimization. The procedure identifies a blade optimum for a new spar cap laminate characterized by a higher longitudinal Young's modulus and higher cost than the initial one, which however in turn induce both cost and mass savings in the blade. In terms of shell skin, the adoption of a laminate with intermediate properties between a bi-axial one and a tri-axial one also leads to slight structural improvements.

  11. Modelling survival

    DEFF Research Database (Denmark)

    Ashauer, Roman; Albert, Carlo; Augustine, Starrlight

    2016-01-01

    The General Unified Threshold model for Survival (GUTS) integrates previously published toxicokinetic-toxicodynamic models and estimates survival with explicitly defined assumptions. Importantly, GUTS accounts for time-variable exposure to the stressor. We performed three studies to test...

  12. Development, Use and Maintenance of the Design Basis Threat. Implementing Guide (Arabic Edition)

    International Nuclear Information System (INIS)

    2009-01-01

    threat to those assets. As described in this publication, an understanding of the threat can lead to a detailed description of potential adversaries (the design basis threat), which, in turn, is the basis of an appropriately designed physical protection system. This direct link gives confidence that protection would be effective against an adversary attack. International experience in using a design basis threat to protect assets of high consequence is largely based on the protection of nuclear material and facilities. Furthermore, the nuclear security documents defining and recommending that physical protection be based upon the threat. The Physical Protection Objectives and Fundamental Principles, the Recommendations on the Physical Protection of Nuclear Facilities and Nuclear Material, and the Convention on Physical Protection of Nuclear Facilities and Nuclear Material as Amended - do so exclusively for the protection of nuclear material and facilities. Given the historical background, and its continuing contemporary relevance, it has been necessary to draw on that nuclear protection experience in developing this publication. However, the general approach can also be applied to protecting other assets that require a high degree of confidence in the effectiveness of their protection, such as high-activity radioactive material. Specialists from France, Germany, Japan, the Russian Federation, Spain, the United Kingdom, and the United States of America assisted the IAEA in preparing this publication. A draft was presented to an open-ended technical meeting in December 2006, and subsequently circulated for comment to all Member States. This publication is consistent with The Physical Protection Objectives and Fundamental Principles; the Convention on Physical Protection of Nuclear Facilities and Nuclear Material as Amended; and the Recommendations on the Physical Protection of Nuclear Facilities and Nuclear Material.

  13. Development, use and maintenance of the design basis threat. Implementing guide

    International Nuclear Information System (INIS)

    2009-01-01

    threat to those assets. As described in this publication, an understanding of the threat can lead to a detailed description of potential adversaries (the design basis threat), which, in turn, is the basis of an appropriately designed physical protection system. This direct link gives confidence that protection would be effective against an adversary attack. International experience in using a design basis threat to protect assets of high consequence is largely based on the protection of nuclear material and facilities. Furthermore, the nuclear security documents defining and recommending that physical protection be based upon the threat - The Physical Protection Objectives and Fundamental Principles (GOV/2001/41/ Attachment), the Recommendations on the Physical Protection of Nuclear Facilities and Nuclear Material (INFCIRC/225/Rev. 4 (corrected)), and the Convention on Physical Protection of Nuclear Facilities and Nuclear Material as Amended (INFCIRC/274) (adopted on 8 July 2005; (GOV/2005/57)) - do so exclusively for the protection of nuclear material and facilities. Given the historical background, and its continuing contemporary relevance, it has been necessary to draw on that nuclear protection experience in developing this publication. However, the general approach can also be applied to protecting other assets that require a high degree of confidence in the effectiveness of their protection, such as high-activity radioactive material. Specialists from France, Germany, Japan, the Russian Federation, Spain, the United Kingdom, and the United States of America assisted the IAEA in preparing this publication. A draft was presented to an open-ended technical meeting in December 2006, and subsequently circulated for comment to all Member States. This publication is consistent with The Physical Protection Objectives and Fundamental Principles; the Convention on Physical Protection of Nuclear Facilities and Nuclear Material as Amended; and the Recommendations on the

  14. Regulatory Guide 1.122: Development of floor design response spectra for seismic design of floor-supported equipment or components

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    ''Reactor Site Criteria,'' requires, in part, that safety-related structures, systems, and components remain functional in the event of a Safe Shutdown Earthquake (SSE). It specifies the use of a suitable dynamic analysis as one method of ensuring that the structures, systems, and components can withstand the seismic loads. Similarly, paragraph (a)(2) of Section VI of the same appendix requires, in part, that the structures, systems, and components necessary for continued operation without undue risk to the health and safety of the public remain functional in the event of an Operating Basis Earthquake (OBE). Again, the use of suitable dynamic analysis is specified as one method of ensuring that the structures, systems, and components can withstand the seismic loads. This guide describes methods acceptable to the NRC staff for developing two horizontal and one vertical floor design response spectra at various floors or other equipment-support locations of interest from the time-history motions resulting from the dynamic analysis of the supporting structure. These floor design response spectra are needed for the dynamic analysis of the systems or equipment supported at various locations of the supporting structure

  15. Survival analysis

    International Nuclear Information System (INIS)

    Badwe, R.A.

    1999-01-01

    The primary endpoint in the majority of the studies has been either disease recurrence or death. This kind of analysis requires a special method since all patients in the study experience the endpoint. The standard method for estimating such survival distribution is Kaplan Meier method. The survival function is defined as the proportion of individuals who survive beyond certain time. Multi-variate comparison for survival has been carried out with Cox's proportional hazard model

  16. Steel — ab Initio: Quantum Mechanics Guided Design of New Fe-Based Materials

    Science.gov (United States)

    Prahl, Ulrich; Bleck, Wolfgang; Saeed-Akbari, Alireza

    This contribution reports the results of the collaborative research unit SFB 761 "Steel — ab initio", a cooperative project between RWTH Aachen University and the Max-Planck-Institute for Iron Research in Düsseldorf (MPIE) financed by the German Research Foundation (DFG). For the first time, it is exploited how ab initio approaches may lead to a detailed understanding and thus to a specific improvement of material development. The challenge lies in the combination of abstract natural science theories with rather engineering-like established concepts. Aiming at the technological target of the development of a new type of structural materials based on Fe-Mn-C alloys, the combination of ab initio and engineering methods is new, but could be followed quite successfully. Three major topics are treated in this research unit: a) development of a new method for material- and process-development based on ab initio calculations; b) design of a new class of structural materials with extraordinary property combinations; c) acceleration of development time and reduction of experimental efforts and complexity for material- and process-development. In the present work, an overview of the results of the first five years as well as an outlook for the upcoming three-year period is given.

  17. Homebuyer's Guide.

    Science.gov (United States)

    Sindt, Roger P.; Harris, Jack

    Designed to assist prospective buyers in making such important decisions as whether to buy a new or older home and within what price range, the guide provides information on the purchase process. Discussion of the purchase process covers the life-cycle costs (recurring homeownership costs that must be met every month); selection of a home;…

  18. A comprehensive guide for designing more efficient irrigation systems with respect to application control

    Science.gov (United States)

    Khaddam, Issam; Schuetze, Niels

    2017-04-01

    The worldwide water scarcity problems are expected to aggravate due to the increasing population and the need to produce more food. Irrigated agriculture is considered the highest consumer of fresh water resources with a rate exceeds 70% of global consumption. Consequently, an improvement in the efficiency of all irrigation methods, such as furrow or drip irrigation, becomes more necessary and urgent. Therefore, a more precise knowledge about soil water distribution in the root zone and the water balance components is required. For this purpose and as a part of the SAPHIR project (Saxonian Platform for high Performance Irrigation), a 2D simulation- based study was performed with virtual field conditions. The study investigates the most important design parameters of many irrigation systems, such as irrigation intensity and duration, and shows there influence on the water distribution efficiency. Furthermore, three main soil textures are used to test the impact of the soil hydraulic properties on irrigation effectiveness. A numerous number of irrigation scenarios of each irrigation system was simulated using HYDRUS 2D. Thereafter, the results were digitally calculated, compiled and made available online in the so called "Irrigation Atlases". The irrigation atlases provide graphical results of the soil moisture and pressure head distributions in the root zone. Moreover, they contain detailed information of the water balance for all simulated scenarios. The most studies evaluate the irrigation water demands on local, regional or global scales and for that an efficient water distribution is required. In this context, the irrigation atlases can serve as a valuable tool for the implementation of planned irrigation measures.

  19. A novel approach for computer-assisted template-guided autotransplantation of teeth with custom 3d designed/printed surgical tooling. An ex vivo proof of concept

    NARCIS (Netherlands)

    Anssari Moin, D.; Derksen, W.; Verweij, J.P.; van Merkesteyn, R.; Wismeijer, D.

    2016-01-01

    Purpose: The aim of this study was to introduce a novel method for accurate autotransplantation with computer-assisted guided templates and assembled custom-designed surgical tooling and to test the feasibility and accuracy of this method ex vivo. Materials and Methods: A partially edentulous human

  20. Accuracy of computer-assisted template-guided autotransplantation of teeth with custom three-dimensional designed/printed surgical tooling : A cadaveric study

    NARCIS (Netherlands)

    Anssari Moin, D.; Verweij, J.P.; Waars, H.; van Merkesteyn, R.; Wismeijer, D.

    2017-01-01

    Purpose: The aim of the present cadaveric study was to assess the accuracy of computer-assisted template-guided autotransplantation of teeth with custom 3-dimensional (3D) designed/printed surgical tooling. Materials and Methods: Ten partially edentulous human mandibular cadavers were scanned using

  1. "Off-Spotter": very fast and exhaustive enumeration of genomic lookalikes for designing CRISPR/Cas guide RNAs.

    Science.gov (United States)

    Pliatsika, Venetia; Rigoutsos, Isidore

    2015-01-29

    CRISPR/Cas (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated nucleases) is a powerful component of the prokaryotic immune system that has been adapted for targeted genetic engineering in higher organisms. A key element of CRISPR/Cas is the "guide" RNA (gRNA) that is ~20 nucleotides (nts) in length and designed to be complementary to the intended target site. An integral requirement of the CRISPR/Cas system is that the target site be followed by a protospacer adjacent motif (PAM). Care needs to be exercised during gRNA design to avoid unintended ("off-target") interactions. We designed and implemented the Off-Spotter algorithm to assist with the design of optimal gRNAs. When presented with a candidate gRNA sequence and a PAM, Off-Spotter quickly and exhaustively identifies all genomic sites that satisfy the PAM constraint and are identical or nearly-identical to the provided gRNA. Off-Spotter achieves its extreme performance through purely algorithmic means and not through hardware accelerators such as graphical processing units (GPUs). Off-Spotter also allows the user to identify on-the-fly how many and which nucleotides of the gRNA comprise the "seed". Off-Spotter's output includes a histogram showing the number of potential off-targets as a function of the number of mismatches. The output also includes for each potential off-target the site's genomic location, a human genome browser hyperlink to the corresponding location, genomic annotation in the vicinity of the off-target, GC content, etc. Off-Spotter is very fast and flexible and can help in the design of optimal gRNAs by providing several PAM choices, a run-time definition of the seed and of the allowed number of mismatches, and a flexible output interface that allows sorting of the results, optional viewing/hiding of columns, etc. A key element of Off-Spotter is that it does not have a rigid definition of the seed: instead, the user can declare both the seed's location and extent

  2. Relationship between product demand, tibial polyethylene insert shelf age, and total knee arthroplasty survival: retrospective review of total knees of one design.

    Science.gov (United States)

    Urban, Joshua A; Collier, Matthew B; Engh, C Anderson; Engh, Gerard A

    2006-04-01

    Shelf aging of gamma-irradiated-in-air polyethylene tibial components has been associated with increased articular surface wear and an elevated risk for revision. Nine hundred fifty cruciate-retaining inserts of one design were implanted between 1987 and 1996 (shelf age, 1.0 +/- 1.2 years). Less frequently used inserts (smallest/largest sizes, thicker thicknesses, supplemental articular constraint) had longer shelf ages (means ranged from 1.2 to 2.6 years). Survival analysis showed that shelf age (P product demand and can be of aid when diagnosing the painful knee.

  3. A bifurcation study to guide the design of a landing gear with a combined uplock/downlock mechanism.

    Science.gov (United States)

    Knowles, James A C; Lowenberg, Mark H; Neild, Simon A; Krauskopf, Bernd

    2014-12-08

    This paper discusses the insights that a bifurcation analysis can provide when designing mechanisms. A model, in the form of a set of coupled steady-state equations, can be derived to describe the mechanism. Solutions to this model can be traced through the mechanism's state versus parameter space via numerical continuation, under the simultaneous variation of one or more parameters. With this approach, crucial features in the response surface, such as bifurcation points, can be identified. By numerically continuing these points in the appropriate parameter space, the resulting bifurcation diagram can be used to guide parameter selection and optimization. In this paper, we demonstrate the potential of this technique by considering an aircraft nose landing gear, with a novel locking strategy that uses a combined uplock/downlock mechanism. The landing gear is locked when in the retracted or deployed states. Transitions between these locked states and the unlocked state (where the landing gear is a mechanism) are shown to depend upon the positions of two fold point bifurcations. By performing a two-parameter continuation, the critical points are traced to identify operational boundaries. Following the variation of the fold points through parameter space, a minimum spring stiffness is identified that enables the landing gear to be locked in the retracted state. The bifurcation analysis also shows that the unlocking of a retracted landing gear should use an unlock force measure, rather than a position indicator, to de-couple the effects of the retraction and locking actuators. Overall, the study demonstrates that bifurcation analysis can enhance the understanding of the influence of design choices over a wide operating range where nonlinearity is significant.

  4. A bifurcation study to guide the design of a landing gear with a combined uplock/downlock mechanism

    Science.gov (United States)

    Knowles, James A. C.; Lowenberg, Mark H.; Neild, Simon A.; Krauskopf, Bernd

    2014-01-01

    This paper discusses the insights that a bifurcation analysis can provide when designing mechanisms. A model, in the form of a set of coupled steady-state equations, can be derived to describe the mechanism. Solutions to this model can be traced through the mechanism's state versus parameter space via numerical continuation, under the simultaneous variation of one or more parameters. With this approach, crucial features in the response surface, such as bifurcation points, can be identified. By numerically continuing these points in the appropriate parameter space, the resulting bifurcation diagram can be used to guide parameter selection and optimization. In this paper, we demonstrate the potential of this technique by considering an aircraft nose landing gear, with a novel locking strategy that uses a combined uplock/downlock mechanism. The landing gear is locked when in the retracted or deployed states. Transitions between these locked states and the unlocked state (where the landing gear is a mechanism) are shown to depend upon the positions of two fold point bifurcations. By performing a two-parameter continuation, the critical points are traced to identify operational boundaries. Following the variation of the fold points through parameter space, a minimum spring stiffness is identified that enables the landing gear to be locked in the retracted state. The bifurcation analysis also shows that the unlocking of a retracted landing gear should use an unlock force measure, rather than a position indicator, to de-couple the effects of the retraction and locking actuators. Overall, the study demonstrates that bifurcation analysis can enhance the understanding of the influence of design choices over a wide operating range where nonlinearity is significant. PMID:25484601

  5. The cure: design and evaluation of a crowdsourcing game for gene selection for breast cancer survival prediction.

    Science.gov (United States)

    Good, Benjamin M; Loguercio, Salvatore; Griffith, Obi L; Nanis, Max; Wu, Chunlei; Su, Andrew I

    2014-07-29

    Molecular signatures for predicting breast cancer prognosis could greatly improve care through personalization of treatment. Computational analyses of genome-wide expression datasets have identified such signatures, but these signatures leave much to be desired in terms of accuracy, reproducibility, and biological interpretability. Methods that take advantage of structured prior knowledge (eg, protein interaction networks) show promise in helping to define better signatures, but most knowledge remains unstructured. Crowdsourcing via scientific discovery games is an emerging methodology that has the potential to tap into human intelligence at scales and in modes unheard of before. The main objective of this study was to test the hypothesis that knowledge linking expression patterns of specific genes to breast cancer outcomes could be captured from players of an open, Web-based game. We envisioned capturing knowledge both from the player's prior experience and from their ability to interpret text related to candidate genes presented to them in the context of the game. We developed and evaluated an online game called The Cure that captured information from players regarding genes for use as predictors of breast cancer survival. Information gathered from game play was aggregated using a voting approach, and used to create rankings of genes. The top genes from these rankings were evaluated using annotation enrichment analysis, comparison to prior predictor gene sets, and by using them to train and test machine learning systems for predicting 10 year survival. Between its launch in September 2012 and September 2013, The Cure attracted more than 1000 registered players, who collectively played nearly 10,000 games. Gene sets assembled through aggregation of the collected data showed significant enrichment for genes known to be related to key concepts such as cancer, disease progression, and recurrence. In terms of the predictive accuracy of models trained using this

  6. Survival of falling robots

    Science.gov (United States)

    Cameron, Jonathan M.; Arkin, Ronald C.

    1992-01-01

    As mobile robots are used in more uncertain and dangerous environments, it will become important to design them so that they can survive falls. In this paper, we examine a number of mechanisms and strategies that animals use to withstand these potentially catastrophic events and extend them to the design of robots. A brief survey of several aspects of how common cats survive falls provides an understanding of the issues involved in preventing traumatic injury during a falling event. After outlining situations in which robots might fall, a number of factors affecting their survival are described. From this background, several robot design guidelines are derived. These include recommendations for the physical structure of the robot as well as requirements for the robot control architecture. A control architecture is proposed based on reactive control techniques and action-oriented perception that is geared to support this form of survival behavior.

  7. Survival of falling robots

    Science.gov (United States)

    Cameron, Jonathan M.; Arkin, Ronald C.

    1992-02-01

    As mobile robots are used in more uncertain and dangerous environments, it will become important to design them so that they can survive falls. In this paper, we examine a number of mechanisms and strategies that animals use to withstand these potentially catastrophic events and extend them to the design of robots. A brief survey of several aspects of how common cats survive falls provides an understanding of the issues involved in preventing traumatic injury during a falling event. After outlining situations in which robots might fall, a number of factors affecting their survival are described. From this background, several robot design guidelines are derived. These include recommendations for the physical structure of the robot as well as requirements for the robot control architecture. A control architecture is proposed based on reactive control techniques and action-oriented perception that is geared to support this form of survival behavior.

  8. Design, Development and Preliminary Student Evaluation of Virtual Field Guides as aids to teaching and learning in the Earth sciences

    Science.gov (United States)

    Stott, Tim

    2010-05-01

    , J., Kneale, P., Sougnez, Y., Stewart, M., and Stott, T. A. (2003). Carrying out Pedagogic research into the Constructive Alignment of Fieldwork. Planet Special Edition 5: Linking Teaching and Research and undertaking Pedagogic Research in Geography, Earth and Environmental Sciences, 51-52. Carmichael, P. (2008) ‘The Semantic Web and ‘Web 3.0' in: Selwyn, N. (ed.) Education 2.0? Designing the web for teaching and learning. London: ESRC Teaching and Learning Research Programme. Fletcher, S., France, D., Moore, K. and Robinson, G. (2002). Fieldwork education and technology: A GEES perspective, Planet 4, 17-19. Fletcher, S., France, D., Moore, K. and Robinson, G. (2007). Putting technology into fieldwork education: A pedagogic evaluation. Journal of Geography in Higher Education 31, 2, 319 - 330 Maskall, J., Stokes, A., Truscott, J. B., Bridge, A., Magnier, K. and Calderbank, V. (2007) Supporting fieldwork using information technology, Planet 18, 18-21. Stott, TA., Nuttall, AM. and McCloskey, J. (2009a) Design, Development and Student Evaluation of a Virtual Alps Field Guide www.virtualalps.co.uk. Planet 22, 64-71. Publication of the Higher Education Academy Subject Centre for Geography, Earth and Environmental Sciences, Learning & Teaching Support Network www.gees.ac.uk/planet/. Stott, TA, Clark, H., Milson, C., McCloskey, J. and Crompton, K. (2009b) The Ingleton Waterfalls Virtual Field Trip: Design, Development and Preliminary Evaluation, Teaching Earth Sciences 34 (1), 13-19, Magazine of the Earth Science Teachers Association.

  9. Design of Epoxy based Resin Composites for Automotive Applications: A Case Study on IC Engine Valve Guide

    Science.gov (United States)

    Sidhu, J. S.; Lathkar, G. S.; Sharma, S. B.

    2018-01-01

    The present attempt in this project is to reduce the vibrations, temperature due to friction, noise and weight of I C engine valve guide by replacing conventional metal valve guide with composite valve guide. Composite materials have been used in automotive components because of their properties such as low weight, high specific stiffness, corrosion resistance, ability to produce complex shapes, high specific strength and good impact energy absorption etc. The Internal combustion engine valve guides are the parts that support the valves in the cylinder head, besides this it keeps lubricating oil from getting sucked into the combustion chamber past the intake valve stem, it keeps exhaust gases from getting into the crankcase past the exhaust valve stem and it also keeps the valve face in perfect alignment with the valve seat. A valve guide test rig is indigenously fabricated. Valve guides are manufactured using the developed composite material (Resin ARL-136, Hardener AH-126 and 4 vol% WS2), on a CNC lathe. The performance of the developed composite guide under varied conditions of speeds, that is, fixed change in rpm and modulated changes in rpm is assessed. Noise, temperature and vibrations are measured. The experimental data revealed that contribution of composite guide in respect of acceleration, velocity and displacement components of vibration is not substantial. A substantial reduction in noise levels is seen. As far as temperature rise due to friction is concerned maximum components fail at elevated temperatures, with composite guides the temperature generated due to friction at higher speeds is less, a considerable weight reduction is also observed.

  10. Computer-designed surgical guide template compared with free-hand operation for mesiodens extraction in premaxilla using “trapdoor” method

    Science.gov (United States)

    Hu, Ying Kai; Xie, Qian Yang; Yang, Chi; Xu, Guang Zhou

    2017-01-01

    Abstract The aim of this study was to introduce a novel method of mesiodens extraction using a vascularized pedicled bone flap by piezosurgery and to compare the differences between a computer-aided design surgical guide template and free-hand operation. A total of 8 patients with mesiodens, 4 with a surgical guide (group I), and 4 without it (group II) were included in the study. The surgical design was to construct a trapdoor pedicle on the superior mucoperiosteal attachment with application of piezosurgery. The bone lid was repositioned after mesiodens extraction. Group I patients underwent surgeries based on the preoperative planning with surgical guide templates, while group II patients underwent free-hand operation. The outcome variables were success rate, intraoperative time, anterior nasal spine (ANS) position, changes of nasolabial angle (NLA), and major complications. Data from the 2 groups were compared by SPSS 17.0, using Wilcoxon test. The operative time was significantly shorter in group I patients. All the mesiodentes were extracted successfully and no obvious differences of preoperative and postoperative ANS position and NLA value were found in both groups. The patients were all recovered uneventfully. Surgical guide templates can enhance clinical accuracy and reduce operative time by facilitating accurate osteotomies. PMID:28658139

  11. Design and Laboratory Level Production of High Energy Survival Tablets for Athletes, Tourists and People who Faced Natural Disasters

    Directory of Open Access Journals (Sweden)

    A Nezami Asl

    2016-03-01

    Full Text Available Introduction: People affected by natural disasters like flood or earthquakes and also athletes like mountain climbers and also sailors who continuously go to jungles or deserts, might get into trouble in the nature and need help to get back to their home and therefore, they might need high energy supplements to keep them alive up to the time they find a food source. The goal of this study was to design and make these laboratory prototypes of high energy tablets. Methods: For making tablets 15 different formulations were designed and made in the laboratory and then were tested to be suit. We objected to design formulations that could provide at least 20 kcal per each tab and amount of daily protein (about 25 grams, Tablets were design to provide not only the minimum energy needed but also the minimum protein needs and daily requirements of some vitamins and minerals of a healthy male adult. Results: Laboratory samples of 5 gram high energy (21 Kcal were produced. The best formulation that had the capacity to be converted into tablets consisted of olive oil (16%, maltodextrin (36%, high biological value protein powder (25%, sesame seed (17% and wheat germ (6%. 25 tablets should be taken each day which provides 525 kcal energy, 25g protein and different vitamins and minerals, daily; therefore, they will provide the minimum energy needs for at least 10 days if provided in 1.2 kg packs.  Conclusion: The production of high energy tab rations can provide minimum energy needs for at least 7 days for athletes, tourists and people who face natural disasters when there is no access to any other food resources because they occupy the minimum volume and their production is accessible in Iran.

  12. Three Dimensional Analysis of Pier Extension and Guide Wall Design Alternatives to Mitigate Local Scour Risk at the BNSF Railroad Bridge Downstream of the Prado Dam

    Energy Technology Data Exchange (ETDEWEB)

    Lottes, S. A. [Argonne National Lab. (ANL), Argonne, IL (United States); Bojanowski, C. [Argonne National Lab. (ANL), Argonne, IL (United States); Sinha, N. [Argonne National Lab. (ANL), Argonne, IL (United States); Kerenyi, K [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-03-01

    The primary objectives of the computational fluid dynamics (CFD) analysis are (1) to verify that the design concept of using wedge shaped pier extensions to divert flow around piers as a scour counter measure has the intended effect on the flow, (2) to refine the design of the length and orientation of the pier extensions within the channel and (3) to optimize the guide walls that will protect a set of outer piers and the abutments on each side of the channel. The original proposed design is shown in Figure 1.3. The results of this effort are the recommended designs that are judged to be the best designs based on results from the set of test cases run combined with engineering judgment. The refined designs from the CFD analysis are expected to be tested in a limited set of physical model experiments to verify that they work well.

  13. A Guide to the Design of Occupational Safety and Health Training for Immigrant, Latino/a Dairy Workers.

    Science.gov (United States)

    Menger, Lauren M; Rosecrance, John; Stallones, Lorann; Roman-Muniz, Ivette Noami

    2016-01-01

    Industrialized dairy production in the U.S. relies on an immigrant, primarily Latino/a, workforce to meet greater production demands. Given the high rates of injuries and illnesses on U.S. dairies, there is pressing need to develop culturally appropriate training to promote safe practices among immigrant, Latino/a dairy workers. To date, there have been few published research articles or guidelines specific to developing effective occupational safety and health (OSH) training for immigrant, Latino/a workers in the dairy industry. Literature relevant to safety training for immigrant workers in agriculture and other high-risk industries (e.g., construction) was examined to identify promising approaches. The aim of this paper is to provide a practical guide for researchers and practitioners involved in the design and implementation of effective OSH training programs for immigrant, Latino/a workers in the dairy industry. The search was restricted to peer-reviewed academic journals and guidelines published between 1980 and 2015 by universities or extension programs, written in English, and related to health and safety training among immigrant, Latino/a workers within agriculture and other high-risk industries. Relevant recommendations regarding effective training transfer were also included from literature in the field of industrial-organizational psychology. A total of 97 articles were identified, of which 65 met the inclusion criteria and made a unique and significant contribution. The review revealed a number of promising strategies for how to effectively tailor health and safety training for immigrant, Latino/a workers in the dairy industry grouped under five main themes: (1) understanding and involving workers; (2) training content and materials; (3) training methods; (4) maximizing worker engagement; and (5) program evaluation. The identification of best practices in the design and implementation of training programs for immigrant, Latino/a workers within

  14. Preliminary design of high-power wave-guide/transmission system for multimegawatt CW requirements of 100 MeV proton Linac

    International Nuclear Information System (INIS)

    Shrivastava, Purushottam; Wanmode, Y.D.; Hannurkar, P.R.

    2002-01-01

    Development of a 100 MeV CW proton Linac has been planned at CAT. This Linac will be needing CW rf power in the frequency ranges of 350 MHz and 700 MHz for its RFQ and DTL/CCDTL/SFDTL structures respectively. The power to the accelerating structures will be produced by either 1 MW CW or 250 kW CW klystron/inductive output tubes (HOM IOTs). The power needed by respective feed points in the structure is max. 250 kW which will be powered by splitting the power from 1 MW klystron/klystrode into four channels by using a wave-guide system. In case of using 250 kW tubes the power to the structures will be provided directly from each tube. Two types of wave-guide transmission system have been considered, viz WR 2300 for 350 MHz rf needs and WR 1500 for 700 MHz rf needs. The typical wave-guide system has been designed using the 1 MW CW klystron followed by wave-guide filter, dual directional coupler, high-power circulator, three 3 dB magic TEE power dividers to split the main channel into four equal channels of 250 kW each. Each individual channel has dual directional couplers, flexible wave-guide sections and high power ceramic vacuum window. The circulator and each power divider is terminated into the isolated ports by high power CW loads. Out of the four channels three channels have phase shifters. Present paper describes the technological aspects and design specifications-considerations for these stringent requirements. (author)

  15. Design and Analysis of Salmonid Tagging Studies in the Columbia Basin, Volume XXI; A Summary of Methods for Conducting Salmonid Fry Mark-Recapture Studies for Estimating Survival in Tributaries, Technical Report 2005-2006.

    Energy Technology Data Exchange (ETDEWEB)

    Skalski, John

    2007-02-01

    Productivity and early fry survival can have a major influence on the dynamics of fish stocks. To investigate the early life history of fish, numerous methods have been developed or adapted to these much smaller fish. Some of the marking techniques provide individual identification; many others, only class identification. Some of the tagging techniques require destructive sampling to identify a mark; other methods permit benign examination and rerelease of captured fish. Sixteen alternative release-recapture designs for conducting fry survival investigations were examined. Eleven approaches were found capable of estimating survival parameters; five were not. Of those methods capable of estimating fry survival, five required unique marks, four required batch-specific marks, and two approaches required remarking and rereleasing captured fry. No approach based on a simple batch mark was capable of statistically estimating survival.

  16. Activity and Life After Survival of a Cardiac Arrest (ALASCA and the effectiveness of an early intervention service: design of a randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Bakx Wilbert GM

    2007-08-01

    Full Text Available Abstract Background Cardiac arrest survivors may experience hypoxic brain injury that results in cognitive impairments which frequently remain unrecognised. This may lead to limitations in daily activities and participation in society, a decreased quality of life for the patient, and a high strain for the caregiver. Publications about interventions directed at improving quality of life after survival of a cardiac arrest are scarce. Therefore, evidence about effective rehabilitation programmes for cardiac arrest survivors is urgently needed. This paper presents the design of the ALASCA (Activity and Life After Survival of a Cardiac Arrest trial, a randomised, controlled clinical trial to evaluate the effects of a new early intervention service for survivors of a cardiac arrest and their caregivers. Methods/design The study population comprises all people who survive two weeks after a cardiac arrest and are admitted to one of the participating hospitals in the Southern part of the Netherlands. In a two-group randomised, controlled clinical trial, half of the participants will receive an early intervention service. The early intervention service consists of several consultations with a specialised nurse for the patient and their caregiver during the first three months after the cardiac arrest. The intervention is directed at screening for cognitive problems, provision of informational, emotional and practical support, and stimulating self-management. If necessary, referral to specialised care can take place. Persons in the control group will receive the care as usual. The primary outcome measures are the extent of participation in society and quality of life of the patient one year after a cardiac arrest. Secondary outcome measures are the level of cognitive, emotional and cardiovascular impairment and daily functioning of the patient, as well as the strain for and quality of life of the caregiver. Participants and their caregivers will be followed

  17. Computer-aided design and computer-aided modeling (CAD/CAM) generated surgical splints, cutting guides and custom-made implants: Which indications in orthognathic surgery?

    Science.gov (United States)

    Scolozzi, P

    2015-12-01

    The purpose of the present report was to describe our indications, results and complications of computer-aided design and computer-aided modeling CAD/CAM surgical splints, cutting guides and custom-made implants in orthognathic surgery. We analyzed the clinical and radiological data of ten consecutive patients with dentofacial deformities treated using a CAD/CAM technique. Four patients had surgical splints and cutting guides for correction of maxillomandibular asymmetries, three had surgical cutting guides and customized internal distractors for correction of severe maxillary deficiencies and three had custom-made implants for additional chin contouring and/or mandibular defects following bimaxillary osteotomies and sliding genioplasty. We recorded age, gender, dentofacial deformity, surgical procedure and intra- and postoperative complications. All of the patients had stable cosmetic results with a high rate of patient satisfaction at the 1-year follow-up examination. No intra- and/or postoperative complications were encountered during any of the different steps of the procedure. This study demonstrated that the application of CAD/CAM patient-specific surgical splints, cutting guides and custom-made implants in orthognathic surgery allows for a successful outcome in the ten patients presented in this series. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  18. Preparedness Now! An Emergency Survival Guide

    CERN Document Server

    Edwards, Aton

    2009-01-01

    In uncertain times, a solid preparedness plan is essential for every individual and family. PREPAREDNESS NOW! navigates the new realities of twenty-first century living: extreme weather, economic instability, terror attacks, and more. Packed with checklists, resources, and step-by-step instructions, PREPAREDNESS NOW! details everything needed for office, car, and home preparedness. This newly expanded and revised edition includes an extended chapter on food and water storage and urban gardening, techniques in personal defense, and the latest and best preparedness products on the market. This b

  19. An Automation Survival Guide for Media Centers.

    Science.gov (United States)

    Whaley, Roger E.

    1989-01-01

    Reviews factors that should affect the decision to automate a school media center and offers suggestions for the automation process. Topics discussed include getting the library collection ready for automation, deciding what automated functions are needed, evaluating software vendors, selecting software, and budgeting. (CLB)

  20. Bring your own devices (BYOD) survival guide

    CERN Document Server

    Keyes, Jessica

    2013-01-01

    The BYOD RevolutionWhat's in It for the Organization? So, What Can Go Wrong? Mobile Device Management Consumerization of IT Business as UsualMaking a Financial Case for BYOD Supporting BYOD Cost-Benefit Analysis Break-Even Analysis Estimating ROI for an IT Project Earned-Value Management Rapid Economic Justification Value Measuring Methodology      Step 1: Develop a Decision Framework           Task 1-Identify and Define Value Structure           Task 2-Identify and Define Risk Structure           Task 3-Identify and Define Cost Structure           Task 4-Begin Documentation      Step 2: Alter

  1. Parent's Guide to Surviving the Teen Years

    Science.gov (United States)

    ... have about bodies, such as the differences between boys and girls and where babies come from. But don't ... together, and we'll come out of it — together! Reviewed by: Steven Dowshen, MD Date reviewed: January ... Problems in Teens Helping Teens Learn to Drive Talking to Your Child About Puberty ...

  2. Accuracy of Computer-Assisted Template-Guided Autotransplantation of Teeth With Custom Three-Dimensional Designed/Printed Surgical Tooling: A Cadaveric Study.

    Science.gov (United States)

    Anssari Moin, David; Verweij, Jop Pieter; Waars, Hugo; van Merkesteyn, Richard; Wismeijer, Daniel

    2017-05-01

    The aim of the present cadaveric study was to assess the accuracy of computer-assisted template-guided autotransplantation of teeth with custom 3-dimensional (3D) designed/printed surgical tooling. Ten partially edentulous human mandibular cadavers were scanned using a cone-beam computed tomography (CBCT) system and an intraoral scanning system. The 3D data of these cadavers were imported to specialized software and used to analyze the region of the recipient sites, and the donor teeth were selected. Subsequently, congruent to the donor teeth, custom surgical tooling and surgical-guided templates were designed and 3D printed. The guided osteotomies were performed and the donor teeth transplanted. To evaluate the planned donor teeth positions compared with the transplanted donor teeth positions, the mandibles were scanned again using the CBCT system, and software matching was applied to measure the accuracy of the procedure. The mean angular deflection of the transplanted donor teeth with the planned donor teeth positions was 5.6 ± 5.4°. Comparing the 3D positions of the shoulders, a mean deviation of 3.15 ± 1.16 mm and a mean apical deviation of 2.61 ± 0.78 mm were found. The described method of computer-assisted template-guided autotransplantation of teeth with custom 3D designed/printed surgical tooling could potentially provide a relatively accurate alternative for the currently available treatment approaches. Further research should focus on improving the accuracy of this technique and evaluating the clinical success and advantages of this method. Copyright © 2017 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  3. Optimized design of the chopper disks and the neutron guide in a disk chopper neutron time-of-flight spectrometer

    International Nuclear Information System (INIS)

    Copley, J.R.D.

    1990-01-01

    We consider important aspects of the performance of a disk chopper neutron time-of-flight spectrometer. The intensity at the sample position, and the contributions of the choppers to the resolution of the instrument, are evaluated as a function of the widths of the slots in the chopper disks and the width of the neutron guide between the disks. We find that there is an optimum choice of the ratios of these widths and that this choice depends on a single parameter which, for elastic scattering, is a simple ratio of distances. When pairs of counter-rotating disks are employed, the widths of the slots can be modified by grossly changing the phase relationship between the members of a chopper pair. If the slot widths are changed, the width of the guide should also be altered in order to maintain the spectrometer in an optimized state. This change in the guide width may be effectively achieved using an arrangement of nested guides. Resolution and intensity calculations demonstrate the important gains which may be realized using this approach. (orig.)

  4. Verification of neutron pad and 17 x 7 guide tube designs by preoperational tests on the Trojan I power plant

    International Nuclear Information System (INIS)

    Bloyd, C.N.; Singleton, N.R.; Ciaramitaro, W.

    1976-05-01

    The internals vibration measurement program carried out on the Trojan-1 reactor during preoperational testing is described. The flow induced response of a 17 x 17 guide tube and the neutron pad core barrel were deduced from the plant test data and compared with the expected responses. The results showed good agreement with expected vibration levels

  5. Design and Implementation of an Electronic Front-End Based on Square Wave Excitation for Ultrasonic Torsional Guided Wave Viscosity Sensor

    Directory of Open Access Journals (Sweden)

    Amir Rabani

    2016-10-01

    Full Text Available The market for process instruments generally requires low cost devices that are robust, small in size, portable, and usable in-plant. Ultrasonic torsional guided wave sensors have received much attention by researchers for measurement of viscosity and/or density of fluids in recent years. The supporting electronic systems for these sensors providing many different settings of sine-wave signals are bulky and expensive. In contrast, a system based on bursts of square waves instead of sine waves would have a considerable advantage in that respect and could be built using simple integrated circuits at a cost that is orders of magnitude lower than for a windowed sine wave device. This paper explores the possibility of using square wave bursts as the driving signal source for the ultrasonic torsional guided wave viscosity sensor. A simple design of a compact and fully automatic analogue square wave front-end for the sensor is also proposed. The successful operation of the system is demonstrated by using the sensor for measuring the viscosity in a representative fluid. This work provides the basis for design and manufacture of low cost compact standalone ultrasonic guided wave sensors and enlightens the possibility of using coded excitation techniques utilising square wave sequences in such applications.

  6. Design of a Nanoscale, CMOS-Integrable, Thermal-Guiding Structure for Boolean-Logic and Neuromorphic Computation.

    Science.gov (United States)

    Loke, Desmond; Skelton, Jonathan M; Chong, Tow-Chong; Elliott, Stephen R

    2016-12-21

    One of the requirements for achieving faster CMOS electronics is to mitigate the unacceptably large chip areas required to steer heat away from or, more recently, toward the critical nodes of state-of-the-art devices. Thermal-guiding (TG) structures can efficiently direct heat by "meta-materials" engineering; however, some key aspects of the behavior of these systems are not fully understood. Here, we demonstrate control of the thermal-diffusion properties of TG structures by using nanometer-scale, CMOS-integrable, graphene-on-silica stacked materials through finite-element-methods simulations. It has been shown that it is possible to implement novel, controllable, thermally based Boolean-logic and spike-timing-dependent plasticity operations for advanced (neuromorphic) computing applications using such thermal-guide architectures.

  7. Survival Analysis

    CERN Document Server

    Miller, Rupert G

    2011-01-01

    A concise summary of the statistical methods used in the analysis of survival data with censoring. Emphasizes recently developed nonparametric techniques. Outlines methods in detail and illustrates them with actual data. Discusses the theory behind each method. Includes numerous worked problems and numerical exercises.

  8. Expert Guide

    DEFF Research Database (Denmark)

    Heiselberg, Per

    , their benefits and limitations, economical feasibility and impact on energy savings, company image, comfort, productivity, building functionality and flexibility and gives guidance on design of these concepts, including integration of responsive building elements and HVAC-systems and build examples......This guide summarizes the work of Subtask B of IEA-ECBCS Annex 44 “Integrating Environmentally Responsive Elements in Buildings” and is based on the contributions from the participating countries. The publication is an official Annex report. With a focus on innovative building concepts...

  9. Design and fabrication of a nanofibrous polycaprolactone tubular nerve guide for peripheral nerve tissue engineering using a two-pole electrospinning system

    International Nuclear Information System (INIS)

    Panahi-Joo, Y; Abd-Emami, B; Bonakdar, S; Karkhaneh, A; Nourinia, A; Negahdari, B; Renaud, P

    2016-01-01

    Nerve guidance conduits are considered to be the new generation of scaffolds designed for nerve disorders. A tubular construct with a highly aligned fibrous structure, mimicking the endoneurium layer surrounding inner axons of a nerve fascicle, is a suitable candidate for a nerve guide. In this paper a new approach for the fabrication of 3D tubular nerve guides is introduced using simulation of a two-pole electrospinning system and describing its mechanism. The structure of this scaffold is then optimized using the Taguchi statistical method and after morphological studies by scanning electron microscopy, the crystallinity, tensile strength and protein adsorption of these highly aligned fibres are investigated, comparing them with semi-aligned and random fibres produced via conventional mandrel electrospinning. Cell attachment, proliferation and migration of PC12 neuronal like cells are studied on highly aligned, semi aligned and random structures, and morphological change and elongation are observed in PC12 cells. The results of these studies suggest that conduits fabricated using two-pole electrospinning are a suitable and promising scaffold for peripheral and even spinal nerve regeneration. This nerve guide has a great potential for further advanced modifications and regeneration in higher levels. (paper)

  10. The PACKTRAM database on national competent authorities' approval certificates for package design, special form material and shipment of radioactive material. User's guide for compiled system program

    International Nuclear Information System (INIS)

    1995-01-01

    The PACKTRAM system program enables Member States to prepare data diskettes on national competent authorities' approval certificates for package design, special form material and shipment of radioactive material, for submission to the IAEA, and facilitates data manipulation and report preparation for the IAEA. The system program is provided as a 424 kbyte executable file, for which this document is the User Guide. The system is fully menu-driven and requires an IBM-compatible personal computer with a minimum of 640 kbyte random access memory, a hard drive and one 3-1/2 inch diskette drive. 3 refs, 6 tabs

  11. Prosthetically guided bone sculpturing for a maxillary complete-arch implant-supported monolithic zirconia fixed prosthesis based on a digital smile design: A clinical report.

    Science.gov (United States)

    Rojas-Vizcaya, Fernando

    2017-11-01

    A digital smile design was used to create an average smile and to develop a removable interim restoration for an edentulous patient with a high smile line and different bone levels in the maxilla. The interim restoration was used as a guide to perform bone sculpturing to create space for the biological width and to restore a monolithic zirconia implant-supported fixed restoration. Copyright © 2017 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

  12. Graphic Communications. Curriculum Guide.

    Science.gov (United States)

    North Dakota State Board for Vocational Education, Bismarck.

    This guide provides the basic foundation to develop a one-semester course based on the cluster concept, graphic communications. One of a set of six guides for an industrial arts curriculum at the junior high school level, it suggests exploratory experiences designed to (1) develop an awareness and understanding of the drafting and graphic arts…

  13. Collegiate Drug Management Guide.

    Science.gov (United States)

    Janosik, Steven M.; Anderson, David S.

    A checklist to help colleges and universities reevaluate their policies and procedures regarding drug use among college students is presented. It is designed to supplement the "Collegiate Alcohol Risk Assessment Guide." In this guide drugs other than alcohol are of concern, although alcohol is viewed by many as the "drug of choice" among college…

  14. Career Education Instructional Guide.

    Science.gov (United States)

    State Univ. of New York, Oswego. Coll. at Oswego. Dept. of Industrial Arts and Technology.

    The guide is designed primarily for industrial arts teachers at the middle school level who wish to integrate career education into their curricula. The lessons and activities attempt to establish a balance among career information, technical information, and hands-on experience. The guide contains six lesson plans which cover the topics: the…

  15. Network survivability performance (computer diskette)

    Science.gov (United States)

    1993-11-01

    File characteristics: Data file; 1 file. Physical description: 1 computer diskette; 3 1/2 in.; high density; 2.0MB. System requirements: Mac; Word. This technical report has been developed to address the survivability of telecommunications networks including services. It responds to the need for a common understanding of, and assessment techniques for network survivability, availability, integrity, and reliability. It provides a basis for designing and operating telecommunication networks to user expectations for network survivability.

  16. Guiding Requirements for Designing Life Support System Architectures for Crewed Exploration Missions Beyond Low-Earth Orbit

    Science.gov (United States)

    Perry, Jay L.; Sargusingh, Miriam J.; Toomarian, Nikzad

    2016-01-01

    The National Aeronautics and Space Administration's (NASA) technology development roadmaps provide guidance to focus technological development in areas that enable crewed exploration missions beyond low-Earth orbit. Specifically, the technology area roadmap on human health, life support and habitation systems describes the need for life support system (LSS) technologies that can improve reliability and in-flight maintainability within a minimally-sized package while enabling a high degree of mission autonomy. To address the needs outlined by the guiding technology area roadmap, NASA's Advanced Exploration Systems (AES) Program has commissioned the Life Support Systems (LSS) Project to lead technology development in the areas of water recovery and management, atmosphere revitalization, and environmental monitoring. A notional exploration LSS architecture derived from the International Space has been developed and serves as the developmental basis for these efforts. Functional requirements and key performance parameters that guide the exploration LSS technology development efforts are presented and discussed. Areas where LSS flight operations aboard the ISS afford lessons learned that are relevant to exploration missions are highlighted.

  17. Molecular docking guided structure based design of symmetrical N,N'-disubstituted urea/thiourea as HIV-1 gp120-CD4 binding inhibitors.

    Science.gov (United States)

    Sivan, Sree Kanth; Vangala, Radhika; Manga, Vijjulatha

    2013-08-01

    Induced fit molecular docking studies were performed on BMS-806 derivatives reported as small molecule inhibitors of HIV-1 gp120-CD4 binding. Comprehensive study of protein-ligand interactions guided in identification and design of novel symmetrical N,N'-disubstituted urea and thiourea as HIV-1 gp120-CD4 binding inhibitors. These molecules were synthesized in aqueous medium using microwave irradiation. Synthesized molecules were screened for their inhibitory ability by HIV-1 gp120-CD4 capture enzyme-linked immunosorbent assay (ELISA). Designed compounds were found to inhibit HIV-1 gp120-CD4 binding in micromolar (0.013-0.247 μM) concentrations. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. A User’s Guide to the Brave New World of Designing Simulation Experiments. State-of-the-Art Review

    Science.gov (United States)

    2005-01-01

    Bardhan 1995, Saltelli et al. 1999, or Sanchez and Wu 2003). 4.8. Crossed and Combined Array Designs Selecting designs for finding robust solutions falls...5th ed. Wiley, New York. Morrice, D. J., I. R. Bardhan . 1995. A weighted least squares approach to computer simulation factor screening. Oper. Res

  19. Students' Understanding of the Special Theory of Relativity and Design for a Guided Visit to a Science Museum

    Science.gov (United States)

    Guisasola, Jenaro; Solbes, Jordi; Barragues, Jose-Ignacio; Morentin, Maite; Moreno, Antonio

    2009-01-01

    The present paper describes the design of teaching materials that are used as learning tools in school visits to a science museum. An exhibition on "A century of the Special Theory of Relativity", in the Kutxaespacio Science Museum, in San Sebastian, Spain, was used to design a visit for first-year engineering students at the university…

  20. The high performance HMI handbook a comprehensive guide to designing, implementing and maintaining effective HMIs for industrial plant operations

    CERN Document Server

    Hollifield, Bill; Nimmo, Ian; Habibi, Eddie

    2008-01-01

    The High Performance HMI Handbook is the first and only comprehensive book containing the best-practice principles for assessing, designing, and implementing proper process control Human-Machine Interfaces (HMIs). Poorly designed and poorly performing Human Machine Interfaces (HMIs) are rampant throughout the process industries. They can degrade safety, production, quality, and profitability. Time after time, they are cited as contributing factors to major industrial accidents. The book contains experience and intellectual property that has never before been released, It is jointly authored by 2 companies, PAS and User Centered Design Services (UCDS), who have decades of experience in process control, HMI design, and human factors. The book reveals many poor yet common HMI practices, provides the justification for change, and shows in great detail the best way to design and implement a truly High Performance HMI. It contains over 90 color illustrations, plus many relevant real world examples, anecdotes, and ...

  1. Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival

    Directory of Open Access Journals (Sweden)

    Fang Gang

    2008-09-01

    Full Text Available Abstract Background We have engaged in an international program designated the Bank On A Cure, which has established DNA banks from multiple cooperative and institutional clinical trials, and a platform for examining the association of genetic variations with disease risk and outcomes in multiple myeloma. We describe the development and content of a novel custom SNP panel that contains 3404 SNPs in 983 genes, representing cellular functions and pathways that may influence disease severity at diagnosis, toxicity, progression or other treatment outcomes. A systematic search of national databases was used to identify non-synonymous coding SNPs and SNPs within transcriptional regulatory regions. To explore SNP associations with PFS we compared SNP profiles of short term (less than 1 year, n = 70 versus long term progression-free survivors (greater than 3 years, n = 73 in two phase III clinical trials. Results Quality controls were established, demonstrating an accurate and robust screening panel for genetic variations, and some initial racial comparisons of allelic variation were done. A variety of analytical approaches, including machine learning tools for data mining and recursive partitioning analyses, demonstrated predictive value of the SNP panel in survival. While the entire SNP panel showed genotype predictive association with PFS, some SNP subsets were identified within drug response, cellular signaling and cell cycle genes. Conclusion A targeted gene approach was undertaken to develop an SNP panel that can test for associations with clinical outcomes in myeloma. The initial analysis provided some predictive power, demonstrating that genetic variations in the myeloma patient population may influence PFS.

  2. Technical Support Document: Development of the Advanced Energy Design Guide for Medium Box Retail -- 50% Energy Savings

    Energy Technology Data Exchange (ETDEWEB)

    Hale, E. T.; Macumber, D. L.; Long, N. L.; Griffith, B. T.; Benne, K. S.; Pless, S. D.; Torcellini, P. A.

    2008-09-01

    This report provides recommendations that architects, designers, contractors, developers, owners, and lessees of medium box retail buildings can use to achieve whole-building energy savings of at least 50% over ASHRAE Standard 90.1-2004. The recommendations are given by climate zone and address building envelope, fenestration, lighting systems, HVAC systems, building automation and controls, outside air treatment, service water heating, plug loads, and photovoltaic systems. The report presents several paths to 50% savings, which correspond to different levels of integrated design. These are recommendations only, and are not part of a code or standard. The recommendations are not exhaustive, but we do try to emphasize the benefits of integrated building design, that is, a design approach that analyzes a building as a whole system, rather than as a disconnected collection of individually engineered subsystems.

  3. Decreasing spatial disorientation in care-home settings: How psychology can guide the development of dementia friendly design guidelines.

    Science.gov (United States)

    O'Malley, Mary; Innes, Anthea; Wiener, Jan M

    2017-04-01

    Alzheimer's disease results in marked declines in navigation skills that are particularly pronounced in unfamiliar environments. However, many people with Alzheimer's disease eventually face the challenge of having to learn their way around unfamiliar environments when moving into assisted living or care-homes. People with Alzheimer's disease would have an easier transition moving to new residences if these larger, and often more institutional, environments were designed to compensate for decreasing orientation skills. However, few existing dementia friendly design guidelines specifically address orientation and wayfinding. Those that do are often based on custom, practice or intuition and not well integrated with psychological and neuroscientific knowledge or navigation research, therefore often remaining unspecific. This paper discusses current dementia friendly design guidelines, reports findings from psychological and neuropsychological experiments on navigation and evaluates their potential for informing design guidelines that decrease spatial disorientation for people with dementia.

  4. Performance-oriented packaging: A guide to identifying and designing. Identifying and designing hazardous materials packaging for compliance with post HM-181 DOT Regulations

    International Nuclear Information System (INIS)

    1994-08-01

    With the initial publication of Docket HM-181 (hereafter referred to as HM-181), the U.S. Department of Energy (DOE), Headquarters, Transportation Management Division decided to produce guidance to help the DOE community transition to performance-oriented packagings (POP). As only a few individuals were familiar with the new requirements, elementary guidance was desirable. The decision was to prepare the guidance at a level easily understood by a novice to regulatory requirements. This document identifies design development strategies for use in obtaining performance-oriented packagings that are not readily available commercially. These design development strategies will be part of the methodologies for compliance with post HM-181 U.S. Department of Transportation (DOT) packaging regulations. This information was prepared for use by the DOE and its contractors. The document provides guidance for making decisions associated with designing performance-oriented packaging, and not for identifying specific material or fabrication design details. It does provide some specific design considerations. Having a copy of the regulations handy when reading this document is recommended to permit a fuller understanding of the requirements impacting the design effort. While this document is not written for the packaging specialist, it does contain guidance important to those not familiar with the new POP requirements

  5. [Design and clinical application of the drilling guide in the treatment of acromioclavicular joint dislocation with closed reduction and Kirschner fixation].

    Science.gov (United States)

    Zhou, Song; Hao, Yong-qiang; Shi, Xiao-lin; Zhao, Huan-li; Gao, Kai-tuo; Sun, Jin-xu

    2011-03-01

    To investigate a drilling guide in the treatment of acromioclavicular joint dislocation with closed reduction and Kirschner fixation and explore the therapeutic effect. From June 2008 to December 2009, 36 patients with acromioclavicular joint dislocation (Tossy III) were treated with closed reduction and Kirschner fixation using a self-designed drilling guide as well as percutaneous repair of acromioclavicular joint. Among the patients, 24 patients were male and 12 patients were female,ranging in age from 20 to 61 years, averaged 38.6 years. The duration from injury to operation ranged from 3.5 to 72 h,with a mean of 15.2 h. No clavicle fracture was found in all cases. The operative time, intra-operative bleeding and therapeutic effects were observed. There were no complications including neurovascular problems. The mean operating time were 20 min,mean blood loss were about 10 ml. According to the observation of postoperative X-ray examination, all Kirschners in acromioclavicular joint were in place. All Kirschners were removed in 6 postoperative weeks. All the patients were followed up ranging from 2 to 26 months (averaged 14.3 months). According to the Karlsson standard,22 patients got an excellent result, 13 good and 1 poor. This method has following advantages: easy operation and fixation; minimum injuries to articular surface; and which would be widely used in clinical practice.

  6. The promise and challenge of practice-research collaborations: Guiding principles and strategies for initiating, designing, and implementing program evaluation research.

    Science.gov (United States)

    Secret, Mary; Abell, Melissa L; Berlin, Trey

    2011-01-01

    The authors present a set of guiding principles and strategies to facilitate the collaborative efforts of social work researchers and practitioners as they initiate, design, and implement outcome evaluations of human service interventions and programs. Beginning with an exploration of the interpersonal barriers to practice-research collaborations, and building on their experiences in successfully completing a community-based research evaluation, the authors identify specific relationship-focused principles and strategies and illustrate how these approaches can guide practice-research teams through the various sequential activities of the evaluation research process. In particular, it is suggested that practice-research collaborations can be formed, strengthened, and sustained by emphasis on a spirit of discovery and shared leadership at the start of the relationship, use of a comprehensive evaluation model to clarify and frame the evaluation and program goals, beginning where the client is when selecting research methodology and measurement tools, commitment to keeping the program first and recording everything during the implementation and data-collection stages, discussion of emerging findings and presentation of findings in graphic format at the data-analysis stage, and a total team approach at the dissemination stage.

  7. 分宜县天工广场铺装的导向性功能设计%Guiding Function Design of the City Square Pavement——Taking Tiangong Square in Jiangxi Province as an Example

    Institute of Scientific and Technical Information of China (English)

    梁维; 杨柳青; 田兵

    2012-01-01

    In this day and age,the expression of cultural and participative characteristics of the city square design has been paid more and more attention to.However,how to complete the guiding function systematically in the pavement design of City Square is a problem that has been overlooked.In addition,the fusion of guiding function and other expressions is a difficult problem that lots of cities are facing during designing the square pavement.Based on the study of the pavement design of Jiangxi Tiangong Square,this paper intends to analyse the guiding function of square pavement,find a suitable way to express the guiding function of square pavement and use those findings to guide the design of pavement of the city squares.%指出了城市广场铺装设计中系统的完成导向性功能在城市广场设计中对于其文化性、参与性的表达具有重要意义,通过对江西省分宜县天工广场铺装设计的研究,分析了广场铺装的导向性功能,探讨了铺装导向性功能表达形式,为城市广场的铺装设计提供参考。

  8. Light Water Reactor Sustainability Program Operator Performance Metrics for Control Room Modernization: A Practical Guide for Early Design Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Ronald Boring; Roger Lew; Thomas Ulrich; Jeffrey Joe

    2014-03-01

    As control rooms are modernized with new digital systems at nuclear power plants, it is necessary to evaluate the operator performance using these systems as part of a verification and validation process. There are no standard, predefined metrics available for assessing what is satisfactory operator interaction with new systems, especially during the early design stages of a new system. This report identifies the process and metrics for evaluating human system interfaces as part of control room modernization. The report includes background information on design and evaluation, a thorough discussion of human performance measures, and a practical example of how the process and metrics have been used as part of a turbine control system upgrade during the formative stages of design. The process and metrics are geared toward generalizability to other applications and serve as a template for utilities undertaking their own control room modernization activities.

  9. A model-based meta-analysis of monoclonal antibody pharmacokinetics to guide optimal first-in-human study design

    Science.gov (United States)

    Davda, Jasmine P; Dodds, Michael G; Gibbs, Megan A; Wisdom, Wendy; Gibbs, John P

    2014-01-01

    The objectives of this retrospective analysis were (1) to characterize the population pharmacokinetics (popPK) of four different monoclonal antibodies (mAbs) in a combined analysis of individual data collected during first-in-human (FIH) studies and (2) to provide a scientific rationale for prospective design of FIH studies with mAbs. The data set was composed of 171 subjects contributing a total of 2716 mAb serum concentrations, following intravenous (IV) and subcutaneous (SC) doses. mAb PK was described by an open 2-compartment model with first-order elimination from the central compartment and a depot compartment with first-order absorption. Parameter values obtained from the popPK model were further used to generate optimal sampling times for a single dose study. A robust fit to the combined data from four mAbs was obtained using the 2-compartment model. Population parameter estimates for systemic clearance and central volume of distribution were 0.20 L/day and 3.6 L with intersubject variability of 31% and 34%, respectively. The random residual error was 14%. Differences (> 2-fold) in PK parameters were not apparent across mAbs. Rich designs (22 samples/subject), minimal designs for popPK (5 samples/subject), and optimal designs for non-compartmental analysis (NCA) and popPK (10 samples/subject) were examined by stochastic simulation and estimation. Single-dose PK studies for linear mAbs executed using the optimal designs are expected to yield high-quality model estimates, and accurate capture of NCA estimations. This model-based meta-analysis has determined typical popPK values for four mAbs with linear elimination and enabled prospective optimization of FIH study designs, potentially improving the efficiency of FIH studies for this class of therapeutics. PMID:24837591

  10. Trimming, Miniaturization and Ideality via Convolution Technique of TRIZ A Guide to Lean and High-level Inventive Design

    CERN Document Server

    Kwatra, Saurabh

    2013-01-01

    The book is a valuable research tool-kit for innovators, amateur & professionals alike. Additionally, College & University faculties on Engineering, who organize yearly workshops internationally will find hundreds of novel themes to choose from. Some teachers might just secretly buy this book to introduce out-of-box brain-teasers in classroom to add fizz to normal (at times boring) lecturing. The book can be used as main/add-on textbook towards following courses: (1) Master's degree programs on design innovation worldwide and (2) Senior undergraduate courses in industrial, engineering & product design.

  11. Diuretic Strategies in Acute Heart Failure and Renal Dysfunction: Conventional vs Carbohydrate Antigen 125-guided Strategy. Clinical Trial Design.

    Science.gov (United States)

    García-Blas, Sergio; Bonanad, Clara; Llàcer, Pau; Ventura, Silvia; Núñez, José María; Sánchez, Ruth; Chamorro, Carlos; Fácila, Lorenzo; de la Espriella, Rafael; Vaquer, Juana María; Cordero, Alberto; Roqué, Mercè; Ortiz, Víctor; Racugno, Paolo; Bodí, Vicent; Valero, Ernesto; Santas, Enrique; Moreno, María Del Carmen; Miñana, Gema; Carratalá, Arturo; Bondanza, Lourdes; Payá, Ana; Cardells, Ingrid; Heredia, Raquel; Pellicer, Mauricio; Valls, Guillermo; Palau, Patricia; Bosch, María José; Raso, Rafael; Sánchez, Andrés; Bertomeu-González, Vicente; Bertomeu-Martínez, Vicente; Montagud-Balaguer, Vicente; Albiach-Montañana, Cristina; Pendás-Meneau, Jezabel; Marcaida, Goitzane; Cervantes-García, Sonia; San Antonio, Rodolfo; de Mingo, Elisabet; Chorro, Francisco J; Sanchis, Juan; Núñez, Julio

    2017-12-01

    The optimal treatment of patients with acute heart failure (AHF) and cardiorenal syndrome type 1 (CRS-1) is far from being well-defined. Arterial hypoperfusion in concert with venous congestion plays a crucial role in the pathophysiology of CRS-I. Plasma carbohydrate antigen 125 (CA125) has emerged as a surrogate of fluid overload in AHF. The aim of this study was to evaluate the clinical usefulness of CA125 for tailoring the intensity of diuretic therapy in patients with CRS-1. Multicenter, open-label, parallel clinical trial, in which patients with AHF and serum creatinine ≥ 1.4mg/dL on admission will be randomized to: a) standard diuretic strategy: titration-based on conventional clinical and biochemical evaluation, or b) diuretic strategy based on CA125: high dose if CA125 > 35 U/mL, and low doses otherwise. The main endpoint will be renal function changes at 24 and 72hours after therapy initiation. Secondary endpoints will include: a) clinical and biochemical changes at 24 and 72hours, and b) renal function changes and major clinical events at 30 days. The results of this study will add important knowledge on the usefulness of CA125 for guiding diuretic treatment in CRS-1. In addition, it will pave the way toward a better knowledge of the pathophysiology of this challenging situation. We hypothesize that higher levels of CA125 will identify a patient population with CRS-1 who could benefit from the use of a more intense diuretic strategy. Conversely, low levels of this glycoprotein could select those patients who would be harmed by high diuretic doses. Copyright © 2017 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

  12. Enhancing Your Public Relations. A Guide for Designing Effective Communication Strategies for Community-Based Vocational Rehabilitation Programs.

    Science.gov (United States)

    DePoint, Beth

    This document is intended to assist agencies in formulating and initiating a financially realistic public relations plan specifically designed for their community-based vocational rehabilitation organizations. The document consists of 6 chapters, a 43-item bibliography, a glossary, and information about the author. Chapter 1 defines public…

  13. High productivity chromatography refolding process for Hepatitis B Virus X (HBx) protein guided by statistical design of experiment studies.

    Science.gov (United States)

    Basu, Anindya; Leong, Susanna Su Jan

    2012-02-03

    The Hepatitis B Virus X (HBx) protein is a potential therapeutic target for the treatment of hepatocellular carcinoma. However, consistent expression of the protein as insoluble inclusion bodies in bacteria host systems has largely hindered HBx manufacturing via economical biosynthesis routes, thereby impeding the development of anti-HBx therapeutic strategies. To eliminate this roadblock, this work reports the development of the first 'chromatography refolding'-based bioprocess for HBx using immobilised metal affinity chromatography (IMAC). This process enabled production of HBx at quantities and purity that facilitate their direct use in structural and molecular characterization studies. In line with the principles of quality by design (QbD), we used a statistical design of experiments (DoE) methodology to design the optimum process which delivered bioactive HBx at a productivity of 0.21 mg/ml/h at a refolding yield of 54% (at 10 mg/ml refolding concentration), which was 4.4-fold higher than that achieved in dilution refolding. The systematic DoE methodology adopted for this study enabled us to obtain important insights into the effect of different bioprocess parameters like the effect of buffer exchange gradients on HBx productivity and quality. Such a bioprocess design approach can play a pivotal role in developing intensified processes for other novel proteins, and hence helping to resolve validation and speed-to-market challenges faced by the biopharmaceutical industry today. Copyright © 2011 Elsevier B.V. All rights reserved.

  14. Surviving Sengstaken.

    Science.gov (United States)

    Jayakumar, S; Odulaja, A; Patel, S; Davenport, M; Ade-Ajayi, N

    2015-07-01

    To report the outcomes of children who underwent Sengstaken-Blakemore tube (SBT) insertion for life-threatening haemetemesis. Single institution retrospective review (1997-2012) of children managed with SBT insertion. Patient demographics, diagnosis and outcomes were noted. Data are expressed as median (range). 19 children [10 male, age 1 (0.4-16) yr] were identified; 18 had gastro-oesophageal varices and 1 aorto-oesophageal fistula. Varices were secondary to: biliary atresia (n=8), portal vein thrombosis (n=5), alpha-1-anti-trypsin deficiency (n=1), cystic fibrosis (n=1), intrahepatic cholestasis (n=1), sclerosing cholangitis (n=1) and nodular hyperplasia with arterio-portal shunt (n=1). Three children deteriorated rapidly and did not survive to have post-SBT endoscopy. The child with an aortooesophageal fistula underwent aortic stent insertion and subsequently oesophageal replacement. Complications included gastric mucosal ulceration (n=3, 16%), pressure necrosis at lips and cheeks (n=6, 31%) and SBT dislodgment (n=1, 6%). Six (31%) children died. The remaining 13 have been followed up for 62 (2-165) months; five required liver transplantation, two underwent a mesocaval shunt procedure and 6 have completed endoscopic variceal obliteration and are under surveillance. SBT can be an effective, albeit temporary, life-saving manoeuvre in children with catastrophic haematemesis. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. Cpf1-Database: web-based genome-wide guide RNA library design for gene knockout screens using CRISPR-Cpf1.

    Science.gov (United States)

    Park, Jeongbin; Bae, Sangsu

    2018-03-15

    Following the type II CRISPR-Cas9 system, type V CRISPR-Cpf1 endonucleases have been found to be applicable for genome editing in various organisms in vivo. However, there are as yet no web-based tools capable of optimally selecting guide RNAs (gRNAs) among all possible genome-wide target sites. Here, we present Cpf1-Database, a genome-wide gRNA library design tool for LbCpf1 and AsCpf1, which have DNA recognition sequences of 5'-TTTN-3' at the 5' ends of target sites. Cpf1-Database provides a sophisticated but simple way to design gRNAs for AsCpf1 nucleases on the genome scale. One can easily access the data using a straightforward web interface, and using the powerful collections feature one can easily design gRNAs for thousands of genes in short time. Free access at http://www.rgenome.net/cpf1-database/. sangsubae@hanyang.ac.kr.

  16. Design of the reactor coolant system and associated systems in nuclear power plants. Safety guide (Spanish Edition); Diseno del sistema de refrigeracion del reactor y los sistemas asociados en las centrales nucleares. Guia de seguridad

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-15

    This Safety Guide was prepared under the IAEA programme for establishing safety standards for nuclear power plants. The basic requirements for the design of safety systems for nuclear power plants are established in the Safety Requirements publication, Safety Standards Series No. NS-R-1 on Safety of Nuclear Power Plants: Design, which it supplements. This Safety Guide describes how the requirements for the design of the reactor coolant system (RCS) and associated systems in nuclear power plants should be met. This publication is a revision and combination of two previous Safety Guides, Safety Series No. 50-SG-D6 on Ultimate Heat Sink and Directly Associated Heat Transport Systems for Nuclear Power Plants (1982), and Safety Series No. 50-SG-D13 on Reactor Coolant and Associated Systems in Nuclear Power Plants (1987), which are superseded by this new Safety Guide. The revision takes account of developments in the design of the RCS and associated systems in nuclear power plants since the earlier Safety Guides were published in 1982 and 1987, respectively. The other objectives of the revision are to ensure consistency with Ref., issued in 2004, and to update the technical content. In addition, an appendix on pressurized heavy water reactors (PHWRs) has been included.

  17. Human factors guides

    International Nuclear Information System (INIS)

    Penington, J.

    1995-10-01

    This document presents human factors guides, which have been developed in order to provide licensees of the AECB with advice as to how to address human factors issues within the design and assessment process. This documents presents the results of a three part study undertaken to develop three guides which are enclosed in this document as Parts B, C and D. As part of the study human factors standards, guidelines, handbooks and other texts were researched, to define those which would be most useful to the users of the guides and for the production of the guides themselves. Detailed specifications were then produced to outline the proposed contents and format of the three guides. (author). 100 refs., 3 tabs., 11 figs

  18. Human factors guides

    Energy Technology Data Exchange (ETDEWEB)

    Penington, J [PHF Services Inc., (Canada)

    1995-10-01

    This document presents human factors guides, which have been developed in order to provide licensees of the AECB with advice as to how to address human factors issues within the design and assessment process. This documents presents the results of a three part study undertaken to develop three guides which are enclosed in this document as Parts B, C and D. As part of the study human factors standards, guidelines, handbooks and other texts were researched, to define those which would be most useful to the users of the guides and for the production of the guides themselves. Detailed specifications were then produced to outline the proposed contents and format of the three guides. (author). 100 refs., 3 tabs., 11 figs.

  19. Nuclear war survival skills

    International Nuclear Information System (INIS)

    Kearney, C.H.

    1979-09-01

    This book includes chapters on psychological preparations, warning and communications, and evacuation. It describes the building of expedient shelters, their ventilation and cooling, the purification and storage of adequate water, the processing and cooking of whole grains and legumes, fallout meters, protection against fires and carbon monoxide, and expedient furnishings for shelters. Other chapters cover sanitation and preventive medicine, medical advice for nuclear survivors lacking the help of doctors, improvised footwear and clothing, and advice on minimum preparations that can be made at low cost and should be made before a crisis arises. One appendix of the handbook gives detailed, field-tested instructions for building six types of earth-covered expedient fallout shelters, with criteria to guide the choice of which shelter to build. Others contain instructions for making an efficient shelter-ventilating pump and a homemade fallout meter that is accurate and dependable with inexpensive materials found in most households. This report is primarily a compilation and summary of civil defense measures and inventions developed at ORNL over the past 14 years and field-tested in six states, from Florida to Utah. It is the first comprehensive handbook of survival information for use by untrained citizens who want to improve their chances of surviving a possible nuclear attack. Sections may be easily excerpted and reproduced for mass distribution through news media

  20. Alarm management for process control a best-practice guide for design, implementation, and use of industrial alarm systems

    CERN Document Server

    Rothenberg, Douglas H

    2014-01-01

    No modern industrial enterprise, particularly in such areas as chemical processing, can operate without a secure, and reliable, network of automated monitors and controls. And those operations need alarm systems to alert engineers and managers the moment anything goes wrong or needs attention. This book, by one of the world's leading experts on industrial alarm systems, will provide A to Z coverage of designing, implementing, and maintaining an effective alarm network.

  1. Design and technical evaluation of fibre-coupled Raman probes for the image-guided discrimination of cancerous skin

    International Nuclear Information System (INIS)

    Schleusener, J; Reble, C; Helfmann, J; Gersonde, I; Cappius, H-J; Glanert, M; Fluhr, J W; Meinke, M C

    2014-01-01

    Two different designs for fibre-coupled Raman probes are presented that are optimized for discriminating cancerous and normal skin by achieving high epithelial sensitivity to detect a major component of the Raman signal from the depth range of the epithelium. This is achieved by optimizing Raman spot diameters to the range of ≈200 µm, which distinguishes this approach from the common applications of either Raman microspectroscopy (1–5 µm) or measurements on larger sampling volume using spot sizes of a few mm. Video imaging with a depicted area in the order of a few cm, to allow comparing Raman measurements to the location of the histo-pathologic findings, is integrated in both designs. This is important due to the inhomogeneity of cancerous lesions. Video image acquisition is achieved using white light LED illumination, which avoids ambient light artefacts. The design requirements focus either on a compact light-weight configuration, for pen-like handling, or on a video-visible measurement spot to enable increased positioning accuracy. Both probes are evaluated with regard to spot size, Rayleigh suppression, background fluorescence, depth sensitivity, clinical handling and ambient light suppression. Ex vivo measurements on porcine ear skin correlates well with findings of other groups. (paper)

  2. THE GUIDE OF THE DESIGN ETHICS THEORY TO THE DESIGN OF THE CONTEMPORARY CERAMICS FOR DALLY USE%设计伦理学对当代日用陶瓷设计的规范引导

    Institute of Scientific and Technical Information of China (English)

    邹晓松; 孟凡茜

    2013-01-01

    This paper, from the research perspective of the design ethics, uses the development characteristics of contemporary ceramics for daily use as the basic point, elaborating how the design ethics guide the design practice of ceramic products for daily use, from the utilitarian realm of serving the human use and the aesthetic realm of serving the human emotions, eventually reach the ethical realm of serving the entire ecosystem. At last, This paper proposes that the new generation of designers should establish correct concept of the design ethics, while creating objects, creating harmonious natural and social environment.%从设计伦理学的研究角度,以当代日用陶瓷本身的发展特征为基本点,阐述设计伦理学如何引导日用陶瓷产品设计实践从服务于人类使用的功利境界,服务于人类情感的审美境界,最终到达服务于整个生态系统的伦理境界.并提出新一代的设计师应树立正确的设计伦理观念,在创物的同时,创造出和谐的自然环境和社会环境.

  3. The Design and Analysis of Salmonid Tagging Studies in the Columbia Basin; Volume XII; A Multinomial Model for Estimating Ocean Survival from Salmonid Coded Wire-Tag Data.

    Energy Technology Data Exchange (ETDEWEB)

    Ryding, Kristen E.; Skalski, John R.

    1999-06-01

    The purpose of this report is to illustrate the development of a stochastic model using coded wire-tag (CWT) release and age-at-return data, in order to regress first year ocean survival probabilities against coastal ocean conditions and climate covariates.

  4. Synthesis of a designed transmembrane protein by thioether ligation of solubilised segments : Nα-haloacetylated peptides survived resin cleavage using TFA with EDT as scavenger

    NARCIS (Netherlands)

    Englebretsen, D.R; Choma, C.T.; Robillard, G.T.

    1998-01-01

    Nα-haloacetylated peptides made by Fmoc solid phase synthesis survived cleavage when EDT was used as a cleavage component. Two segments of a desgned transmembrane protein, one bromoacetylated, the other containing a cysteine, and each bearing a "solubilising tail" peptide, were synthesised by Fmoc

  5. TH-AB-BRA-01: A Novel Doubly-Focused Multileaf Collimator Design for MR-Guided Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Li, H; Mutic, S; Green, O [Washington University School of Medicine, St. Louis, MO (United States); Low, D [UCLA, Los Angeles, CA (United States); Fought, G; Kawrakow, I; Sharma, A; Shvartsman, S; Dempsey, J [ViewRay, Inc., Oakwood Village, OH (United States)

    2016-06-15

    Purpose: To describe the physical and dosimetric properties of a novel double-stack multileaf collimator (MLC). Methods: One of the compromises made in the MLC design has been to employ linear-motion singly-divergent shapes. Because the MLC leading edge moves linearly, it is rounded to provide a consistent, albeit compromised penumbra. The MLC employed in the new linac-based MR-IGRT unit is designed to be doubly focused in that each leaf moves in an arc centered at the source, and the sides of the leaves are machined such that they lie parallel to a line between the leaf edge and the source. The curvature of the MLC keeps motors and encoders in lower magnetic field. However, high spatial-resolution leaves are difficult to manufacture to sufficiently tight tolerances and difficult to move due to restricted space on the gantry. Wider leaves alleviate this problem with less moving parts but the coarse resolution disallows treating very small lesions. This compromise has been overcome by splitting the MLC leaf bank into two sets, stacked one upon the other and offset half of a leaf width. The dosimetry has been simulated using Monte-Carlo and a 6 MV linac in a 0.35 T magnetic field. Results: The combined MLC leaf set has a spatial resolution of effectively half of the leaf width, 4mm here. The dosimetry resolution and conformality are consistent with 4mm wide MLC assisted by inverse fluence modulation. Also, because each leaf junction is backed up by the stacked leaf that lies over the junction, the problem of tongue-and-groove dosimetry has been greatly reduced. The novel MLC design allows the use of more powerful leaf motors than would be otherwise possible if a single MLC bank is employed. Conclusions: The stacked MLC will provide highly conformal dose distributions suitable for stereotactic radiation therapy of small lesions. The research was funded by ViewRay, Inc.

  6. TH-AB-BRA-01: A Novel Doubly-Focused Multileaf Collimator Design for MR-Guided Radiation Therapy

    International Nuclear Information System (INIS)

    Li, H; Mutic, S; Green, O; Low, D; Fought, G; Kawrakow, I; Sharma, A; Shvartsman, S; Dempsey, J

    2016-01-01

    Purpose: To describe the physical and dosimetric properties of a novel double-stack multileaf collimator (MLC). Methods: One of the compromises made in the MLC design has been to employ linear-motion singly-divergent shapes. Because the MLC leading edge moves linearly, it is rounded to provide a consistent, albeit compromised penumbra. The MLC employed in the new linac-based MR-IGRT unit is designed to be doubly focused in that each leaf moves in an arc centered at the source, and the sides of the leaves are machined such that they lie parallel to a line between the leaf edge and the source. The curvature of the MLC keeps motors and encoders in lower magnetic field. However, high spatial-resolution leaves are difficult to manufacture to sufficiently tight tolerances and difficult to move due to restricted space on the gantry. Wider leaves alleviate this problem with less moving parts but the coarse resolution disallows treating very small lesions. This compromise has been overcome by splitting the MLC leaf bank into two sets, stacked one upon the other and offset half of a leaf width. The dosimetry has been simulated using Monte-Carlo and a 6 MV linac in a 0.35 T magnetic field. Results: The combined MLC leaf set has a spatial resolution of effectively half of the leaf width, 4mm here. The dosimetry resolution and conformality are consistent with 4mm wide MLC assisted by inverse fluence modulation. Also, because each leaf junction is backed up by the stacked leaf that lies over the junction, the problem of tongue-and-groove dosimetry has been greatly reduced. The novel MLC design allows the use of more powerful leaf motors than would be otherwise possible if a single MLC bank is employed. Conclusions: The stacked MLC will provide highly conformal dose distributions suitable for stereotactic radiation therapy of small lesions. The research was funded by ViewRay, Inc.

  7. A Designer’s Guide to Human Performance Modelling (La Modelisation des Performances Humaines: Manuel du Concepteur).

    Science.gov (United States)

    1998-12-01

    into the Systems Engineering Process 17 5.3 Validation of HPMs 18 5.4 Commercialisation of human performance modelling software 18 5.5 Model Tool...budget) so that inappropriate models/tools are not offered. The WG agreed that another form of ’ educating ’ designers in the use of models was by means... Commercialisation of human performance modelling Software 5.2.8 Include human performance in system test. g More and more, customer’s are mandating the provision

  8. A robotic C-arm cone beam CT system for image-guided proton therapy: design and performance.

    Science.gov (United States)

    Hua, Chiaho; Yao, Weiguang; Kidani, Takao; Tomida, Kazuo; Ozawa, Saori; Nishimura, Takenori; Fujisawa, Tatsuya; Shinagawa, Ryousuke; Merchant, Thomas E

    2017-11-01

    A ceiling-mounted robotic C-arm cone beam CT (CBCT) system was developed for use with a 190° proton gantry system and a 6-degree-of-freedom robotic patient positioner. We report on the mechanical design, system accuracy, image quality, image guidance accuracy, imaging dose, workflow, safety and collision-avoidance. The robotic CBCT system couples a rotating C-ring to the C-arm concentrically with a kV X-ray tube and a flat-panel imager mounted to the C-ring. CBCT images are acquired with flex correction and maximally 360° rotation for a 53 cm field of view. The system was designed for clinical use with three imaging locations. Anthropomorphic phantoms were imaged to evaluate the image guidance accuracy. The position accuracy and repeatability of the robotic C-arm was high (robotic CBCT system provides high-accuracy volumetric image guidance for proton therapy. Advances in knowledge: Ceiling-mounted robotic CBCT provides a viable option than CT on-rails for partial gantry and fixed-beam proton systems with the added advantage of acquiring images at the treatment isocentre.

  9. Faculty development initiatives designed to promote leadership in medical education. A BEME systematic review: BEME Guide No. 19.

    Science.gov (United States)

    Steinert, Yvonne; Naismith, Laura; Mann, Karen

    2012-01-01

    Due to the increasing complexity of medical education and practice, the preparation of healthcare professionals for leadership roles and responsibilities has become increasingly important. To date, the literature on faculty development designed to promote leadership in medical education has not been reviewed in a systematic fashion. The objective of this review is to synthesize the existing evidence that addresses the following question: 'What are the effects of faculty development interventions designed to improve leadership abilities on the knowledge, attitudes, and skills of faculty members in medicine and on the institutions in which they work?' The search, which covered the period 1980-2009, included six databases (Medline, EMBASE, CINAHL, Web of Science, ERIC, and ABI/Inform) and used the following keywords: faculty development; in-service training; doctor; medic; physician; faculty; leadership; management; administration; executive; and change agent. Hand searches were also conducted, and expert recommendations were solicited. Articles with a focus on faculty development to improve leadership, targeting basic science and clinical faculty members, were reviewed. All study designs that included outcome data beyond participant satisfaction were examined. From an initial 687 unique records, 48 articles met the review criteria in three broad categories: (1) reports in which leadership was the primary focus of the intervention; (2) reports in which leadership was a component of a broader focus on educational development; and (3) reports in which leadership was a component of a broader focus on academic career development. Data were extracted by three coders using the standardized Best Evidence Medical Education coding sheet adapted for our use. One reviewer coded all of the articles, and two reviewers each coded half of the dataset. Coding differences were resolved through discussion. Data were synthesized using Kirkpatrick's four levels of educational outcomes

  10. Theory-Guided Materials Design of Multi-Phase Ti-Nb Alloys with Bone-Matching Elastic Properties

    Directory of Open Access Journals (Sweden)

    Jörg Neugebauer

    2012-10-01

    Full Text Available We present a scale-bridging approach for modeling the integral elasticresponse of polycrystalline composite that is based on a multi-disciplinary combination of(i parameter-free first-principles calculations of thermodynamic phase stability andsingle-crystal elastic stiffness; and (ii homogenization schemes developed forpolycrystalline aggregates and composites. The modeling is used as a theory-guidedbottom-up materials design strategy and applied to Ti-Nb alloys as promising candidatesfor biomedical implant applications. The theoretical results (i show an excellent agreementwith experimental data and (ii reveal a decisive influence of the multi-phase character ofthe polycrystalline composites on their integral elastic properties. The study shows thatthe results based on the density functional theory calculations at the atomistic level canbe directly used for predictions at the macroscopic scale, effectively scale-jumping severalorders of magnitude without using any empirical parameters.

  11. Mirrors in the PDB: left-handed alpha-turns guide design with D-amino acids.

    Science.gov (United States)

    Annavarapu, Srinivas; Nanda, Vikas

    2009-09-22

    Incorporating variable amino acid stereochemistry in molecular design has the potential to improve existing protein stability and create new topologies inaccessible to homochiral molecules. The Protein Data Bank has been a reliable, rich source of information on molecular interactions and their role in protein stability and structure. D-amino acids rarely occur naturally, making it difficult to infer general rules for how they would be tolerated in proteins through an analysis of existing protein structures. However, protein elements containing short left-handed turns and helices turn out to contain useful information. Molecular mechanisms used in proteins to stabilize left-handed elements by L-amino acids are structurally enantiomeric to potential synthetic strategies for stabilizing right-handed elements with D-amino acids. Propensities for amino acids to occur in contiguous alpha(L) helices correlate with published thermodynamic scales for incorporation of D-amino acids into alpha(R) helices. Two backbone rules for terminating a left-handed helix are found: an alpha(R) conformation is disfavored at the amino terminus, and a beta(R) conformation is disfavored at the carboxy terminus. Helix capping sidechain-backbone interactions are found which are unique to alpha(L) helices including an elevated propensity for L-Asn, and L-Thr at the amino terminus and L-Gln, L-Thr and L-Ser at the carboxy terminus. By examining left-handed alpha-turns containing L-amino acids, new interaction motifs for incorporating D-amino acids into right-handed alpha-helices are identified. These will provide a basis for de novo design of novel heterochiral protein folds.

  12. Mirrors in the PDB: left-handed α-turns guide design with D-amino acids

    Directory of Open Access Journals (Sweden)

    Nanda Vikas

    2009-09-01

    Full Text Available Abstract Background Incorporating variable amino acid stereochemistry in molecular design has the potential to improve existing protein stability and create new topologies inaccessible to homochiral molecules. The Protein Data Bank has been a reliable, rich source of information on molecular interactions and their role in protein stability and structure. D-amino acids rarely occur naturally, making it difficult to infer general rules for how they would be tolerated in proteins through an analysis of existing protein structures. However, protein elements containing short left-handed turns and helices turn out to contain useful information. Molecular mechanisms used in proteins to stabilize left-handed elements by L-amino acids are structurally enantiomeric to potential synthetic strategies for stabilizing right-handed elements with D-amino acids. Results Propensities for amino acids to occur in contiguous αL helices correlate with published thermodynamic scales for incorporation of D-amino acids into αR helices. Two backbone rules for terminating a left-handed helix are found: an αR conformation is disfavored at the amino terminus, and a βR conformation is disfavored at the carboxy terminus. Helix capping sidechain-backbone interactions are found which are unique to αL helices including an elevated propensity for L-Asn, and L-Thr at the amino terminus and L-Gln, L-Thr and L-Ser at the carboxy terminus. Conclusion By examining left-handed α-turns containing L-amino acids, new interaction motifs for incorporating D-amino acids into right-handed α-helices are identified. These will provide a basis for de novo design of novel heterochiral protein folds.

  13. Instantaneous Wave-Free Ratio versus Fractional Flow Reserve guided intervention (iFR-SWEDEHEART): Rationale and design of a multicenter, prospective, registry-based randomized clinical trial.

    Science.gov (United States)

    Götberg, Matthias; Christiansen, Evald H; Gudmundsdottir, Ingibjörg; Sandhall, Lennart; Omerovic, Elmir; James, Stefan K; Erlinge, David; Fröbert, Ole

    2015-11-01

    Instantaneous wave-free ratio (iFR) is a new hemodynamic resting index for assessment of coronary artery stenosis severity. iFR uses high frequency sampling to calculate a gradient across a coronary lesion during a period of diastole. The index has been tested against fractional flow reserve (FFR) and found to have an overall classification agreement of 80% to 85%. Whether the level of disagreement is clinically relevant is unknown. Clinical outcome data on iFR are scarce. This study is a registry-based randomized clinical trial, which is a novel strategy using health quality registries as on-line platforms for randomization, case record forms, and follow-up. iFR-SWEDEHEART is a multicenter, prospective, randomized, controlled, clinical open-label clinical trial. Two thousand patients with stable angina or acute coronary syndrome and an indication for physiology-guided assessment of one or more coronary stenoses will be randomized 1:1 to either iFR- or FFR-guided intervention. The randomization will be conducted online in the Swedish web-based system for enhancement and development of evidence-based care in heart disease evaluated according to recommended therapies (SWEDEHEART) registry. The trial has a non-inferiority design, with a primary combined end point of all-cause death, non-fatal myocardial infarction, and unplanned revascularization at 12 months. End points will be identified through national registries and undergo central blind adjudication to ensure data quality. The iFR-SWEDEHEART trial is an registry-based randomized clinical trial evaluating the safety and efficacy of the diagnostic method iFR compared to FFR. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. Reviews and syntheses: guiding the evolution of the observing system for the carbon cycle through quantitative network design

    Science.gov (United States)

    Kaminski, Thomas; Rayner, Peter Julian

    2017-10-01

    Various observational data streams have been shown to provide valuable constraints on the state and evolution of the global carbon cycle. These observations have the potential to reduce uncertainties in past, current, and predicted natural and anthropogenic surface fluxes. In particular such observations provide independent information for verification of actions as requested by the Paris Agreement. It is, however, difficult to decide which variables to sample, and how, where, and when to sample them, in order to achieve an optimal use of the observational capabilities. Quantitative network design (QND) assesses the impact of a given set of existing or hypothetical observations in a modelling framework. QND has been used to optimise in situ networks and assess the benefit to be expected from planned space missions. This paper describes recent progress and highlights aspects that are not yet sufficiently addressed. It demonstrates the advantage of an integrated QND system that can simultaneously evaluate a multitude of observational data streams and assess their complementarity and redundancy.

  15. Thermodynamic and Structure Guided Design of Statin Based Inhibitors of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase

    Energy Technology Data Exchange (ETDEWEB)

    Sarver, Ronald W.; Bills, Elizabeth; Bolton, Gary; Bratton, Larry D.; Caspers, Nicole L.; Dunbar, James B.; Harris, Melissa S.; Hutchings, Richard H.; Kennedy, Robert M.; Larsen, Scott D.; Pavlovsky, Alexander; Pfefferkorn, Jeffrey A.; Bainbridge, Graeme (Pfizer)

    2008-10-02

    Clinical studies have demonstrated that statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) inhibitors, are effective at lowering mortality levels associated with cardiovascular disease; however, 2--7% of patients may experience statin-induced myalgia that limits compliance with a treatment regimen. High resolution crystal structures, thermodynamic binding parameters, and biochemical data were used to design statin inhibitors with improved HMGR affinity and therapeutic index relative to statin-induced myalgia. These studies facilitated the identification of imidazole 1 as a potent (IC{sub 50} = 7.9 nM) inhibitor with excellent hepatoselectivity (>1000-fold) and good in vivo efficacy. The binding of 1 to HMGR was found to be enthalpically driven with a {Delta}H of -17.7 kcal/M. Additionally, a second novel series of bicyclic pyrrole-based inhibitors was identified that induced order in a protein flap of HMGR. Similar ordering was detected in a substrate complex, but has not been reported in previous statin inhibitor complexes with HMGR.

  16. A mathematical model of superparamagnetic iron oxide nanoparticle magnetic behavior to guide the design of novel nanomaterials

    International Nuclear Information System (INIS)

    Ortega, Ryan A.; Giorgio, Todd D.

    2012-01-01

    Superparamagnetic iron oxide nanoparticles (SPIONs) exhibit unique magnetic properties that make them highly efficacious as MR imaging contrast agents and laboratory diagnostic tools. The complexity of SPION magnetic behavior and the multiple parameters affecting this behavior complicate attempts at fabricating particles suited for a particular purpose. A mathematical model of SPION magnetic properties derived from experimental relationships and first principles can be an effective design tool for predicting particle behavior before materials are fabricated. Here, a novel model of SPION magnetic properties is described, using particle size and applied magnetic field as the primary variable inputs. The model is capable of predicting particle susceptibility and non-linear particle magnetization as well as describing the vector magnetic field produced by a single particle in an applied field. Magnetization values produced by the model agree with recent experimental measurements of particle magnetizations. The model is used to predict the complex magnetic behavior of clustered magnetic particles in simulated in vivo environment; specifically, interactions between the clusters and water molecules. The model shows that larger particles exhibit more linear magnetic behavior and stronger magnetization and that clusters of smaller particles allow for more numerous SPION–water molecule interactions and more uniform cluster magnetizations.

  17. Translation of Contextual Control Model to chronic disease management: A paradigm to guide design of cognitive support systems.

    Science.gov (United States)

    Leecaster, Molly K; Weir, Charlene R; Drews, Frank A; Hellewell, James L; Bolton, Daniel; Jones, Makoto M; Nebeker, Jonathan R

    2017-07-01

    Electronic health records (EHRs) continue to be criticized for providing poor cognitive support. Defining cognitive support has lacked theoretical foundation. We developed a measurement model of cognitive support based on the Contextual Control Model (COCOM), which describes control characteristics of an "orderly" joint system and proposes 4 levels of control: scrambled, opportunistic, tactical, and strategic. 35 clinicians (5 centers) were interviewed pre and post outpatient clinical visits and audiotaped during the visit. Behaviors pertaining to hypertension management were systematically mapped to the COCOM control characteristics of: (1) time horizon, (2) uncertainty assessment, (3) consideration of multiple goals, (4) causal model described, and (5) explicitness of plan. Each encounter was classified for overall mode of control. Visits with deviation versus no deviation from hypertension goals were compared. Reviewer agreement was high. Control characteristics differed significantly between deviation groups (Wilcox rank sum p<.01). K-means cluster analysis of control characteristics, stratified by deviation were distinct, with higher goal deviations associated with more control characteristics. The COCOM control characteristics appear to be areas of potential yield for improved user-experience design. Published by Elsevier Inc.

  18. The design and analysis of salmonid tagging studies in the Columbia Basin. Volume 2: Estimating salmonid survival with combined PIT-CWT tagging. Technical report

    International Nuclear Information System (INIS)

    Newman, K.

    1997-06-01

    Passive Integrated Transponder (PIT) tags and Coded Wire Tags (CWTs) in combination can provide information about salmonid survival that single tag releases may not. The release and recapture protocol affects which survival and recapture rates can be estimated and the precision of the estimates. For the particular case of Columbia river salmonids tagged with both PIT tags and CWTs, three different release and recapture protocols were evaluated. This report addresses the need to study the fate of salmon smolt in-river and their subsequent return as adults. Double-tagging procedures are investigated where PIT-tags would be used to provide in-river survival data during smolt outmigrations and coded-wire tags (CWT) used to provide adult return information. This report provides statistical models for the analysis of the joint data as well as recommendations on optimal tagging studies. Study costs and stress on smolt can be reduced by only PIT-tagging a subset of all the fish coded-wire-tagged, while retaining the information content and sampling precision

  19. Network Survivability

    DEFF Research Database (Denmark)

    Marzo, José L.; Stidsen, Thomas Riis; Ruepp, Sarah Renée

    2010-01-01

    – are vital to modern services such as mobile telephony, online banking and VoIP. This book examines communication networking from a mathematical viewpoint. The contributing authors took part in the European COST action 293 – a four-year program of multidisciplinary research on this subject. In this book...... they offer introductory overviews and state-of-the-art assessments of current and future research in the fields of broadband, optical, wireless and ad hoc networks. Particular topics of interest are design, optimization, robustness and energy consumption. The book will be of interest to graduate students......, researchers and practitioners in the areas of networking, theoretical computer science, operations research, distributed computing and mathematics....

  20. Experimental and Computational Mechanistic Studies Guiding the Rational Design of Molecular Electrocatalysts for Production and Oxidation of Hydrogen

    Energy Technology Data Exchange (ETDEWEB)

    Raugei, Simone [Center for Molecular Electrocatalysis,; Helm, Monte L. [Center for Molecular Electrocatalysis,; Hammes-Schiffer, Sharon [Department of Chemistry, University of Illinois at Urbana—Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, United States; Appel, Aaron M. [Center for Molecular Electrocatalysis,; O’Hagan, Molly [Center for Molecular Electrocatalysis,; Wiedner, Eric S. [Center for Molecular Electrocatalysis,; Bullock, R. Morris [Center for Molecular Electrocatalysis,

    2015-11-25

    Understanding how to control the movement of protons and electrons is crucial to the design of fast, efficient electrocatalysts for H2 production and oxidation based on earth-abundant metals. Our work seeks to address fundamental questions about proton movement. We have demonstrated that incorporating a pendant amine functioning as a proton relay in the second coordination sphere of a metal complex helps proton mobility, resulting in faster and more energy-efficient catalysts. Proton-transfer reactions can be rate-limiting and are influenced by several factors, such as pKa values, steric effects, hydrogen bonding, and solvation/desolvation of the exogenous base and acid employed. The presence of multiple protonation sites introduces branching points along the catalytic cycle, making less productive pathways accessible or leading to the formation of stable off-cycle species. Using ligands with only one pendant amine mitigates this problem and results in catalysts with high rates for production of H2, although generally at higher overpotentials. For H2 oxidation catalysts, iron complexes with a high H2 binding affinity were developed. However, these iron complexes had a pKa mismatch between the protonated metal center and the protonated pendant amine, and consequently intramolecular proton movement was slow. Taken altogether, our results demonstrate the necessity of optimizing the entire catalytic cycle because optimization of a specific catalytic step can negatively influence another step and not necessarily lead to a better catalytic performance. We discuss a general procedure, based on thermodynamic arguments, which allows the simultaneous minimization of the free-energy change of each catalytic step, yielding a nearly flat free-energy surface, with no large barriers due to energy mismatches from either high- or low-energy intermediates.