WorldWideScience

Sample records for survey phase ii

  1. Serologic survey for Coxiella burnetii phase II antibodies among slaughterhouse workers in Kerman, southeast of Iran

    Institute of Scientific and Technical Information of China (English)

    Mohammad Khalili; Morteza Mosavi; Hamzeh Ghobadian Diali; Hossein Norouzian Mirza

    2014-01-01

    Objective: To determine the presence of antibodies against phase II among slaughterhouse workers in Kerman, southeast of Iran.Methods:sorbent assay using phase II Coxiella burnetii as the antigen [kit (Virion\\Serion, Wurzburg, Germany) according to the manufacturer’s protocol].Results:The antibody titers of the serum samples were measured by enzyme-linked immuno Conclusions: Our findings suggest that slaughterhouse workers in Kerman area have a higher risk of infection and should consider potential infection with Coxiella burnetii. The positive rate of IgG antibody was 68% in the slaughterhouse workers.

  2. Centrifuge workers study. Phase II, completion report

    Energy Technology Data Exchange (ETDEWEB)

    Wooten, H.D.

    1994-09-01

    Phase II of the Centrifuge Workers Study was a follow-up to the Phase I efforts. The Phase I results had indicated a higher risk than expected among centrifuge workers for developing bladder cancer when compared with the risk in the general population for developing this same type of cancer. However, no specific agent could be identified as the causative agent for these bladder cancers. As the Phase II Report states, Phase I had been limited to workers who had the greatest potential for exposure to substances used in the centrifuge process. Phase II was designed to expand the survey to evaluate the health of all employees who had ever worked in Centrifuge Program Departments 1330-1339 but who had not been interviewed in Phase I. Employees in analytical laboratories and maintenance departments who provided support services for the Centrifuge Program were also included in Phase II. In December 1989, the Oak Ridge Associated Universities (ORAU), now known as Oak Ridge Institute for Science and Education (ORISE), was contracted to conduct a follow-up study (Phase II). Phase H of the Centrifuge Workers Study expanded the survey to include all former centrifuge workers who were not included in Phase I. ORISE was chosen because they had performed the Phase I tasks and summarized the corresponding survey data therefrom.

  3. Phase II Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Schuknecht, Nate [Project Manager; White, David [Principle Investigator; Hoste, Graeme [Research Engineer

    2014-09-11

    The SkyTrough DSP will advance the state-of-the-art in parabolic troughs for utility applications, with a larger aperture, higher operating temperature, and lower cost. The goal of this project was to develop a parabolic trough collector that enables solar electricity generation in the 2020 marketplace for a 216MWe nameplate baseload power plant. This plant requires an LCOE of 9¢/kWhe, given a capacity factor of 75%, a fossil fuel limit of 15%, a fossil fuel cost of $6.75/MMBtu, $25.00/kWht thermal storage cost, and a domestic installation corresponding to Daggett, CA. The result of our optimization was a trough design of larger aperture and operating temperature than has been fielded in large, utility scale parabolic trough applications: 7.6m width x 150m SCA length (1,118m2 aperture), with four 90mm diameter × 4.7m receivers per mirror module and an operating temperature of 500°C. The results from physical modeling in the System Advisory Model indicate that, for a capacity factor of 75%: The LCOE will be 8.87¢/kWhe. SkyFuel examined the design of almost every parabolic trough component from a perspective of load and performance at aperture areas from 500 to 2,900m2. Aperture-dependent design was combined with fixed quotations for similar parts from the commercialized SkyTrough product, and established an installed cost of $130/m2 in 2020. This project was conducted in two phases. Phase I was a preliminary design, culminating in an optimum trough size and further improvement of an advanced polymeric reflective material. This phase was completed in October of 2011. Phase II has been the detailed engineering design and component testing, which culminated in the fabrication and testing of a single mirror module. Phase II is complete, and this document presents a summary of the comprehensive work.

  4. Options Study - Phase II

    Energy Technology Data Exchange (ETDEWEB)

    R. Wigeland; T. Taiwo; M. Todosow; W. Halsey; J. Gehin

    2010-09-01

    The Options Study has been conducted for the purpose of evaluating the potential of alternative integrated nuclear fuel cycle options to favorably address the issues associated with a continuing or expanding use of nuclear power in the United States. The study produced information that can be used to inform decisions identifying potential directions for research and development on such fuel cycle options. An integrated nuclear fuel cycle option is defined in this study as including all aspects of the entire nuclear fuel cycle, from obtaining natural resources for fuel to the ultimate disposal of used nuclear fuel (UNF) or radioactive wastes. Issues such as nuclear waste management, especially the increasing inventory of used nuclear fuel, the current uncertainty about used fuel disposal, and the risk of nuclear weapons proliferation have contributed to the reluctance to expand the use of nuclear power, even though it is recognized that nuclear power is a safe and reliable method of producing electricity. In this Options Study, current, evolutionary, and revolutionary nuclear energy options were all considered, including the use of uranium and thorium, and both once-through and recycle approaches. Available information has been collected and reviewed in order to evaluate the ability of an option to clearly address the challenges associated with the current implementation and potential expansion of commercial nuclear power in the United States. This Options Study is a comprehensive consideration and review of fuel cycle and technology options, including those for disposal, and is not constrained by any limitations that may be imposed by economics, technical maturity, past policy, or speculated future conditions. This Phase II report is intended to be used in conjunction with the Phase I report, and much information in that report is not repeated here, although some information has been updated to reflect recent developments. The focus in this Options Study was to

  5. Solid phase transformations II

    CERN Document Server

    Čermák, J

    2009-01-01

    This topical volume includes ten invited papers that cover selected areas of the field of solid phase transformations. The first two contributions represent a burgeoning branch; that of the computer simulation of physical phenomena. The following three articles deal with the thermodynamics of phase transformations as a basic theory for describing the phenomenology of phase changes in matter. The next paper describes the interconnections between structural stability and the electronic structure of phases. Two further articles are devoted to displacive transformations; a field where there are ma

  6. Phase II Characterization Survey of the USNS Bridge (T-AOE 10), Military Sealift Fleet Support Command, Naval Station, Norfolk, Virginia

    Energy Technology Data Exchange (ETDEWEB)

    ALTIC, NICK A

    2012-08-30

    In March 2011, the USNS Bridge was deployed off northeastern Honshu, Japan with the carrier USS Ronald Reagan to assist with relief efforts after the 2011 Tōhoku earthquake and tsunami. During that time, the Bridge was exposed to air-borne radioactive materials leaking from the damaged Fukushima I Nuclear Power Plant. The proximity of the Bridge to the air-borne impacted area resulted in the contamination of the ship’s air-handling systems and the associated components, as well as potential contamination of other ship surfaces due to either direct intake/deposition or inadvertent spread from crew/operational activities. Preliminary surveys in the weeks after the event confirmed low-level contamination within the heating, ventilation, and air conditioning (HVAC) ductwork and systems, and engine and other auxiliary air intake systems. Some partial decontamination was performed at that time. In response to the airborne contamination event, Military Sealift Fleet Support Command (MSFSC) contracted Oak Ridge Associated Universities (ORAU), under provisions of the Oak Ridge Institute for Science and Education (ORISE) contract, to assess the radiological condition of the Bridge. Phase I identified contamination within the CPS filters, ventilation systems, miscellaneous equipment, and other suspect locations that could not accessed at that time (ORAU 2011b). Because the Bridge was underway during the characterization, all the potentially impacted systems/spaces could not be investigated. As a result, MSFSC contracted with ORAU to perform Phase II of the characterization, specifically to survey systems/spaces previously inaccessible. During Phase II of the characterization, the ship was in port to perform routine maintenance operations, allowing access to the previously inaccessible systems/spaces.

  7. Combustion 2000: Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    1999-11-01

    The goals of the program are to develop a coal-fired high performance power generation system (HIPPS) that is capable of: thermal efficiency (HHV) {ge} 47%; NOx, SOx, and particulates {le} 10% NSPS (New Source Performance Standard); coal providing {ge} 65% of heat input; all solid wastes benign; and cost of electricity {le} 90% of present plants. Phase 1, which began in 1992, focused on the analysis of various configurations of indirectly fired cycles and on technical assessments of alternative plant subsystems and components, including performance requirements, developmental status, design options, complexity and reliability, and capital and operating costs. Phase 1 also included preliminary R and D and the preparation of designs for HIPPS commercial plants approximately 300 MWe in size. This Phase, Phase 2, had as its initial objective the development of a complete design base for the construction and operation of a HIPPS prototype plant to be constructed in Phase 3. As part of a descoping initiative, the Phase 3 program has been eliminated and work related to the commercial plant design has been ended. The rescoped program retained a program of engineering research and development focusing on high temperature heat exchangers, e.g. HITAF development (Task 2); a rescoped Task 6 that is pertinent to Vision 21 objectives and focuses on advanced cycle analysis and optimization, integration of gas turbines into complex cycles, and repowering designs; and preparation of the Phase 2 Technical Report (Task 8). This rescoped program deleted all subsystem testing (Tasks 3, 4,and 5) and the development of a site-specific engineering design and test plan for the HIPPS prototype plant (Task 7). Work reported herein is from: Task 2.1 HITAF Combustors; Task 2.2 HITAF Air Heaters; and Task 6 HIPPS Commercial Plant Design Update.

  8. Status of Gerda Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Victoria [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); Collaboration: GERDA-Collaboration

    2016-07-01

    The GERDA experiment is designed to search for neutrinoless double beta (0νββ) decay of {sup 76}Ge. In Phase I of the experiment a background index (BI) of 10{sup -2} cts/(keV.kg.yr) was reached. No signal has been found and a lower limit on the half-life of 2.1.10{sup 25} yr (at 90% C.L.) is extracted. The aim of Phase II is to double the Ge mass and further reduce the BI by an order of magnitude to explore half-lives of about 10{sup 26} yr. Thirty new Broad Energy Germanium (BEGe) detectors have been produced. These detectors are distinct for their improved energy resolution and enhanced pulse shape discrimination of signal from background events. Further background reduction will be reached by an active veto to read out argon scintillation light. The Phase II commissioning showed that two of the major background components, external γ-rays from {sup 214}Bi and {sup 208}Tl decays, can be suppressed up to two orders of magnitude. This talk presents the current status of the GERDA Phase II upgrade.

  9. The Southern H ii Region Discovery Survey (SHRDS): Pilot Survey

    Science.gov (United States)

    Brown, C.; Jordan, C.; Dickey, John M.; Anderson, L. D.; Armentrout, W. P.; Balser, Dana S.; Bania, T. M.; Dawson, J. R.; McClure-Griffiths, N. M.; Wenger, Trey V.

    2017-07-01

    The Southern H ii Region Discovery Survey is a survey of the third and fourth quadrants of the Galactic plane that will detect radio recombination line (RRL) and continuum emission at cm-wavelengths from several hundred H ii region candidates using the Australia Telescope Compact Array. The targets for this survey come from the WISE Catalog of Galactic H ii Regions and were identified based on mid-infrared and radio continuum emission. In this pilot project, two different configurations of the Compact Array Broad Band receiver and spectrometer system were used for short test observations. The pilot surveys detected RRL emission from 36 of 53 H ii region candidates, as well as seven known H ii regions that were included for calibration. These 36 recombination line detections confirm that the candidates are true H ii regions and allow us to estimate their distances.

  10. The sloan digital sky survey-II supernova survey

    DEFF Research Database (Denmark)

    Frieman, Joshua A.; Bassett, Bruce; Becker, Andrew

    2008-01-01

    The Sloan Digital Sky Survey-II (SDSS-II) has embarked on a multi-year project to identify and measure light curves for intermediate-redshift (0.05 Ia supernovae (SNe Ia) using repeated five-band (ugriz) imaging over an area of 300 sq. deg. The survey region is a stripe 2.5° wide...... spectroscopically confirmed SNe Ia, 30 probable SNe Ia, 14 confirmed SNe Ib/c, 32 confirmed SNe II, plus a large number of photometrically identified SNe Ia, 94 of which have host-galaxy spectra taken so far. This paper provides an overview of the project and briefly describes the observations completed during...

  11. ATLAS Phase-II trigger upgrade

    CERN Document Server

    Sankey, Dave; The ATLAS collaboration

    2016-01-01

    This talk for ACES summarises the current status of the ATLAS Phase-II trigger upgrade, describing and comparing the two architectures under consideration, namely the two hardware level system described in the Phase-II Upgrade Scoping Document and the more recent single hardware level system.

  12. Phase II clinical development of new drugs

    CERN Document Server

    Ting, Naitee; Ho, Shuyen; Cappelleri, Joseph C

    2017-01-01

    This book focuses on how to appropriately plan and develop a Phase II program, and how to design Phase II clinical trials and analyze their data. It provides a comprehensive overview of the entire drug development process and highlights key questions that need to be addressed for the successful execution of Phase II, so as to increase its success in Phase III and for drug approval. Lastly it warns project team members of the common potential pitfalls and offers tips on how to avoid them.

  13. The sloan digital sky survey-II supernova survey

    DEFF Research Database (Denmark)

    Frieman, Joshua A.; Bassett, Bruce; Becker, Andrew

    2008-01-01

    The Sloan Digital Sky Survey-II (SDSS-II) has embarked on a multi-year project to identify and measure light curves for intermediate-redshift (0.05 supernovae (SNe Ia) using repeated five-band (ugriz) imaging over an area of 300 sq. deg. The survey region is a stripe 2.5° wide...... centered on the celestial equator in the Southern Galactic Cap that has been imaged numerous times in earlier years, enabling construction of a deep reference image for the discovery of new objects. Supernova imaging observations are being acquired between September 1 and November 30 of 2005-7. During...... the first two seasons, each region was imaged on average every five nights. Spectroscopic follow-up observations to determine supernova type and redshift are carried out on a large number of telescopes. In its first two three-month seasons, the survey has discovered and measured light curves for 327...

  14. A Comparison of Phase II Study Strategies

    National Research Council Canada - National Science Library

    Sally Hunsberger; Yingdong Zhao; Richard Simon

    2009-01-01

    .... In this article, we compare different phase II study strategies to determine the most efficient drug development path in terms of number of patients and length of time to conclusion of drug efficacy on overall survival...

  15. Small Business Innovation Research GRC Phase I, Phase II, and Post-Phase II Opportunity Assessment for 2015

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.

    2016-01-01

    This report outlines the 2015 Small Business Innovation Research/Small Business Technology Transfer (SBIR/STTR) Phase I, Phase II, and Post-Phase II opportunity contract award results associated with NASA's Aeronautics Research Mission Directorate (ARMD), Human Exploration and Operations Mission Directorate (HEOMD), Science Mission Directorate (SMD), and Space Technology Mission Directorate (STMD) for NASA Glenn Research Center. The report also highlights the number of Phase I, Phase II, and Post-Phase II contracts awarded by mission directorate. The 2015 Phase I contract awards to companies in Ohio and their corresponding technologies are also discussed.

  16. Upgrades for GERDA Phase II

    Science.gov (United States)

    Heisel, Mark

    2014-09-01

    The Germanium Detector Array (GERDA) experiment is searching for the neutrinoless double beta decay (0 νββ) of 76Ge. It is a process that violates lepton number conservation and is predicted to occur in extensions of the standard model of particle physics. GERDA is located underground in the Gran Sasso National Laboratory (LNGS), Italy. An array of bare high-purity germanium detectors enriched in 76Ge is operated in a cryostat with 64 m3 of liquid argon supplemented by a 3 m thick shield of water. The experiment aims at exploring the 0 νββ decay up to a half life of 2 .1026 yr in two phases: Phase I of the experiment has been concluded last year. No signal is observed and the so far best limit is derived for the half life of the 0 νββ decay of 76Ge, T1/20ν power. Low mass detector holders, cold front-end electronics, contacting and cabling schemes are redesigned for ultra low mass and radiopurity. In addition, a retractable liquid argon veto will be installed to efficiently suppress background events that induce scintillation in the liquid argon. A hybrid solution of photomultiplier tubes and silicon photomultipliers coupled to scintillating fibres was chosen. This talk gives an account of the results and these challenging modifications to meet our design goals. The Germanium Detector Array (GERDA) experiment is searching for the neutrinoless double beta decay (0 νββ) of 76Ge. It is a process that violates lepton number conservation and is predicted to occur in extensions of the standard model of particle physics. GERDA is located underground in the Gran Sasso National Laboratory (LNGS), Italy. An array of bare high-purity germanium detectors enriched in 76Ge is operated in a cryostat with 64 m3 of liquid argon supplemented by a 3 m thick shield of water. The experiment aims at exploring the 0 νββ decay up to a half life of 2 .1026 yr in two phases: Phase I of the experiment has been concluded last year. No signal is observed and the so far best

  17. SLUDGE BATCH 6 PHASE II FLOWSHEET SIMULATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Koopman, D.; Best, D.

    2010-03-30

    Two Sludge Receipt and Adjustment Tank (SRAT) runs were used to demonstrate that a fairly wide window of acid stoichiometry was available for processing SB6 Phase II flowsheet simulant (Tank 40 simulant) while still meeting the dual goals of acceptable nitrate destruction and controlled hydrogen generation. Phase II was an intermediate flowsheet study for the projected composition of Tank 40 after transfer of SB6/Tank 51 sludge to the heel of SB5. The composition was based on August 2009 projections. A window of about 50% in total acid was found between acceptable nitrite destruction and excessive hydrogen generation.

  18. LHC Experiments Phase II - TDRs Approval Process

    CERN Document Server

    Forti, F

    2017-01-01

    The overall review process and steps of Phase II were described in CERN-LHCC-2015-077. As experiments submit detailed technical design reports (TDRs), the LHCC and UCG work in close connection to ensure a timely review of the scientific and technical feasibility as well as of the budget and schedule of the upgrade programme.

  19. Care seeking, complementary therapy and herbal medicine use among people with type 2 diabetes and cardiovascular disease CAMELOT phase II: Surveying for diversity

    DEFF Research Database (Denmark)

    Manderson, Lenore; Oldenburg, Brian; Lin, Vivian

    2012-01-01

    prior to the survey, 43% of all respondents had used CAM products or practitioners, including 11% who used Western herbal medicines. The data offers considerable opportunities to tease out the drivers, costs and benefits of CAM use by people with chronic disease. Although findings will be published...

  20. Care seeking, complementary therapy and herbal medicine use among people with type 2 diabetes and cardiovascular disease CAMELOT phase II: Surveying for diversity

    DEFF Research Database (Denmark)

    Manderson, Lenore; Oldenburg, Brian; Lin, Vivian

    2012-01-01

    prior to the survey, 43% of all respondents had used CAM products or practitioners, including 11% who used Western herbal medicines. The data offers considerable opportunities to tease out the drivers, costs and benefits of CAM use by people with chronic disease. Although findings will be published...... across a number of articles, here we profile the demographic and health status characteristics of survey respondents and compare the characteristics of users of naturopathy and Western herbal medicine practitioner with this.......Many Australians manage their health through the combined use of conventional medicine and complementary and alternative medicine, with substantial direct and indirect costs to government and consumers. Our interest was in the varied health practices of people with type 2 diabetes...

  1. The Long Valley Well: Phase II operations

    Energy Technology Data Exchange (ETDEWEB)

    Finger, J.T.

    1992-01-01

    Phase II of the Long Valley Exploratory Well was completed to a depth of 7588 feet in November 1991. The drilling comprised two sub-phases: (1) drilling 17-1/2 inch hole from the Phase I casing shoe at 2558 feet to a depth of 7130 feet, plugging back to 6826 feet, and setting 13-3/8 inch casing at 6825 feet, all during August--September 1991; and (2) returning in November to drill a 3.85-inch core hole deviated out of the previous wellbore at 6868 feet and extending to 7588 feet. Ultimate depth of the well is planned to be 20,000 feet, or at a bottomhole temperature of 500{degrees}C, whichever comes first. Total cost of this drilling phase was approximately $2.3 million, and funding was shared about equally between the California Energy Commission and the Department of Energy. Phase II scientific work will commence in July 1992 and will be supported by DOE Office of Basic Energy Sciences, DOE Geothermal Division, and other funding sources.

  2. The Long Valley Well - Phase II Operations

    Energy Technology Data Exchange (ETDEWEB)

    Finger, John T.

    1992-03-24

    Phase II of the Long Valley Exploratory Well was completed to a depth of 7588 feet in November 1991. The drilling comprised two sub-phases: (1) drilling 17-1/2 inch hole from the Phase I casing shoe at 2558 feet to a depth of 7130 feet, plugging back to 6826 feet, and setting 13-3/8 inch casing at 6825 feet, all during August-September 1991; and (2) returning in November to drill a 3.85-inch core hole deviated out of the previous wellbore at 6808 feet and extending to 7588 feet. Ultimate depth of the well is planned to be 20,000 feet, or at a bottomhole temperature of 500 C, whichever comes first. Total cost of this drilling phase was approximately $2.3 million, and funding was shared about equally between the California Energy Commission and the Department of Energy. Phase II scientific work will commence in July 1992 and will be supported by DOE Office of Basic Energy Sciences, DOE Geothermal Division, and other funding sources.

  3. CMS Forward Calorimeters Phase II Upgrade

    CERN Document Server

    Bilki, Burak

    2014-01-01

    The Phase II Upgrade of the CMS forward calorimeters (electromagnetic and hadronic) originates from the fact that these calorimeters will not be sufficiently performant with the expected High Luminosity LHC conditions, planned to be started in 2025. The major challenge is to preserve/improve the high performance of the current forward detectors with new devices that can withstand the unprecedented radiation levels and disentangle the very large event pileup. CMS elected two design concepts to be presented in the Phase II Upgrade Technical Proposal Shashlik electromagnetic calorimeter + Hadronic Endcap Rebuild, and High Granularity Calorimeter. The former concept is based on reconstructing the endcap electromagnetic calorimeter with a shashlik design and replacing the active media of the endcap hadron calorimeter with radiation tolerant active media with a possibility to extend the coverage. The latter concept is concentrating on constructing a high granularity (both longitudinally and laterally) calorimeter ...

  4. Preliminary CALS Phase II Architecture. Volume 19

    Science.gov (United States)

    1989-07-03

    IDEF ICAM Definition Languages 5 IDEFO ICAM Definition Language: Activity Modeling IDEFIX ICAM Definition Language: Data Modeling 3 IDS Integrated Design...level. At the Conceptual Description level, data are defined by an integrated semantic data model, such as those produced using the IDEFIX modeling...Architecture with the dominate focus on the data dictionary for the IWSDB, represented by an IDEFIX semantic data model. It is at this level that CALS Phase II

  5. Ca II Absorbers in the Sloan Digital Sky Survey: Statistics

    CERN Document Server

    Sardane, Gendith M; Rao, Sandhya M

    2014-01-01

    We present the results of a survey for CaII 3934,3969 absorption-line systems culled from ~ 95,000 Sloan Digital Sky Survey (SDSS) Data Release 7 and Data Release 9 quasar spectra. With 435 doublets identified in the catalog, this list is the largest CaII catalog compiled to date, spanning redshifts z = 0.3 A, is n_0=0.017 +/- 0.001. In comparison to MgII surveys, we found that only 3% of MgII systems in the SDSS have CaII, confirming that it is rare to identify CaII in quasar absorption-line surveys. We also report on some preliminary investigations of the nature of the two populations of CaII absorbers, and show that they can likely be distinguished using their MgII properties.

  6. Status of the GERDA Phase II upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Victoria [Max-Planck-Insitut für Kernphysik, Heidelberg (Germany)

    2016-06-21

    The GERDA experiment is designed to search for neutrinoless double beta (0νββ) decay of {sup 76}Ge. In Phase I of the experiment a background index of 10{sup −2} cts/(keV·kg·yr) was reached. A lower limit on the half-life of the 0νββ decay of {sup 76}Ge was set to 2.1·10{sup 25} yr (at 90% C.L.). The aim of Phase II is to reach a sensitivity of the half-life of about 10{sup 26} yr. To increase the exposure thirty new Broad Energy Germanium (BEGe) detectors have been produced. These detectors are distinct for their improved energy resolution and enhanced pulse shape discrimination of signal from background events. Further background reduction will be reached by a light instrumentation to read out argon scintillation light. In April 2015 the light instrumentation together with eight BEGe detectors has been successfully deployed in the GERDA cryostat. In a commissioning run it was shown that two of the major background components, external γ-rays from {sup 214}Bi and {sup 208}Tl decays, were suppressed up to two orders of magnitude. We are confident to reach a background index of 10{sup −3} cts/(keV·kg·yr) which is the design goal for GERDA Phase II.

  7. Spray Forming Aluminum - Final Report (Phase II)

    Energy Technology Data Exchange (ETDEWEB)

    D. D. Leon

    1999-07-08

    The U.S. Department of Energy - Office of Industrial Technology (DOE) has an objective to increase energy efficient and enhance competitiveness of American metals industries. To support this objective, ALCOA Inc. entered into a cooperative program to develop spray forming technology for aluminum. This Phase II of the DOE Spray Forming Program would translate bench scale spray forming technology into a cost effective world class process for commercialization. Developments under DOE Cooperative Agreement No. DE-FC07-94ID13238 occurred during two time periods due to budgetary constraints; April 1994 through September 1996 and October 1997 and December 1998. During these periods, ALCOA Inc developed a linear spray forming nozzle and specific support processes capable of scale-up for commercial production of aluminum sheet alloy products. Emphasis was given to alloys 3003 and 6111, both being commercially significant alloys used in the automotive industry. The report reviews research performed in the following areas: Nozzel Development, Fabrication, Deposition, Metal Characterization, Computer Simulation and Economics. With the formation of a Holding Company, all intellectual property developed in Phases I and II of the Project have been documented under separate cover for licensing to domestic producers.

  8. Well-integrity survey (Phase II) of abandoned homestead water wells in the High Plains aquifer, former Pantex Ordance Plant and Texas Tech Research Farm near Amarillo, Texas, 1995

    Science.gov (United States)

    Rivers, Glenn A.

    1995-01-01

    This report describes the methods used and the results obtained during a field search for abandoned homestead sites and water wells at the former Pantex Ordnance Plant and Texas Tech Research Farm (Pantex site) near Amarillo, Texas. The search was the second phase of a three-phase well-integrity survey at the Pantex site proposed by the U.S. Army Corps of Engineers.

  9. Low Noise Borehole Triaxial Seismometer Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Kerr, James D; McClung, David W

    2006-11-06

    This report describes the preliminary design and the effort to date of Phase II of a Low Noise Borehole Triaxial Seismometer for use in networks of seismic stations for monitoring underground nuclear explosions. The design uses the latest technology of broadband seismic instrumentation. Each parameter of the seismometer is defined in terms of the known physical limits of the parameter. These limits are defined by the commercially available components, and the physical size constraints. A theoretical design is proposed, and a preliminary prototype model of the proposed instrument has been built. This prototype used the sensor module of the KS2000. The installation equipment (hole locks, etc.) has been designed and one unit has been installed in a borehole. The final design of the sensors and electronics and leveling mechanism is in process. Noise testing is scheduled for the last quarter of 2006.

  10. Status of the Transneptunian Automated Occultation Survey (TAOS II)

    Science.gov (United States)

    Lehner, Matthew; Wang, Shiang-Yu; Alcock, Charles; Reyes-Ruiz, Mauricio; Castro, Joel; Chen, Wen Ping; Chu, You-Hua; Cook, Kem H.; Geary, John C.; Huang, Chung-Kai; Kim, Dae-Won; Norton, Timothy; Szentgyorgyi, Andrew; Yen, WeiLing; Zhang, Zhi-Wei; Figueroa, Liliana

    2016-10-01

    The Transneptunian Automated Occultation Survey (TAOS II) will aim to detect occultations of stars by small (~1 km diameter) objects in the Kuiper Belt and beyond. Such events are very rare ($Construction of the site began in the fall of 2013, and the survey will begin in the summer of 2017. This poster will provide an update on the status of the survey development and the schedule leading to the beginning of survey operations.

  11. The Next Generation Transit Survey - Prototyping Phase

    CERN Document Server

    McCormac, James; Wheatley, Peter; West, Richard; Walker, Simon; Bento, Joao; Skillen, Ian; Faedi, Francesca; Burleigh, Matt; Casewell, Sarah; Chazelas, Bruno; Genolet, Ludovic; Gibson, Neale; Goad, Mike; Lawrie, Katherine; Ryans, Robert; Todd, Ian; Udry, Stephan; Watson, Christopher

    2016-01-01

    We present the prototype telescope for the Next Generation Transit Survey, which was built in the UK in 2008/09 and tested on La Palma in the Canary Islands in 2010. The goals for the prototype system were severalfold: to determine the level of systematic noise in an NGTS-like system; demonstrate that we can perform photometry at the (sub) millimagnitude level on transit timescales across a wide field; show that it is possible to detect transiting super-Earth and Neptune-sized exoplanets and prove the technical feasibility of the proposed planet survey. We tested the system for around 100 nights and met each of the goals above. Several key areas for improvement were highlighted during the prototyping phase. They have been subsequently addressed in the final NGTS facility which was recently commissioned at ESO Cerro Paranal, Chile.

  12. Global phase diagram of disordered type-II Weyl semimetals

    Science.gov (United States)

    Wu, Yijia; Liu, Haiwen; Jiang, Hua; Xie, X. C.

    2017-07-01

    With electron and hole pockets touching at the Weyl node, type-II Weyl semimetal is a newly proposed topological state distinct from its type-I cousin. We numerically study the localization effect for tilted type-I as well as type-II Weyl semimetals and give the global phase diagram. For disordered type-I Weyl semimetal, an intermediate three-dimensional quantum anomalous Hall phase is confirmed between Weyl semimetal phase and diffusive metal phase. However, this intermediate phase is absent for disordered type-II Weyl semimetal. Besides, along the direction of tilt, comparing to its type-I cousin, type-II Weyl semimetal typically possesses longer normalized localization length and therefore it is more robust against disorder. Near the phase boundary between the type-I and the type-II Weyl semimetals, infinitesimal disorder will induce an insulating phase so that, in this region, the concept of Weyl semimetal is meaningless for real materials.

  13. The Data Release of the Sloan Digital Sky Survey-II Supernova Survey

    DEFF Research Database (Denmark)

    Sako, Masao; Bassett, Bruce; C. Becker, Andrew

    2014-01-01

    This paper describes the data release of the Sloan Digital Sky Survey-II (SDSS-II) Supernova Survey conducted between 2005 and 2007. Light curves, spectra, classifications, and ancillary data are presented for 10,258 variable and transient sources discovered through repeat ugriz imaging of SDSS S...

  14. Utility-based optimization of phase II/III programs.

    Science.gov (United States)

    Kirchner, Marietta; Kieser, Meinhard; Götte, Heiko; Schüler, Armin

    2016-01-30

    Phase II and phase III trials play a crucial role in drug development programs. They are costly and time consuming and, because of high failure rates in late development stages, at the same time risky investments. Commonly, sample size calculation of phase III is based on the treatment effect observed in phase II. Therefore, planning of phases II and III can be linked. The performance of the phase II/III program crucially depends on the allocation of the resources to phases II and III by appropriate choice of the sample size and the rule applied to decide whether to stop the program after phase II or to proceed. We present methods for a program-wise phase II/III planning that aim at determining optimal phase II sample sizes and go/no-go decisions in a time-to-event setting. Optimization is based on a utility function that takes into account (fixed and variable) costs of the drug development program and potential gains after successful launch. The proposed methods are illustrated by application to a variety of scenarios typically met in oncology drug development.

  15. First Results of The Konkoly Blazhko Survey II

    CERN Document Server

    Sódor, Á; Molnár, L; Szeidl, B; Hurta, Zs; Bakos, G Á; Hartman, J; Béky, B; Noyes, R W; Sasselov, D; Mazeh, T; Bartus, J; Belucz, B; Hajdu, G; Kővári, Zs; Kun, E; Nagy, I; Posztobányi, K; Smitola, P; Vida, K

    2012-01-01

    The two parts of the Konkoly Blazhko Survey (KBS I and II) are introduced. The most important preliminary findings of the second part are presented in comparison to the results of the first part. Two interesting cases of very strong modulation from the KBS II are also shown.

  16. The Phase II ATLAS ITk Pixel Upgrade

    CERN Document Server

    Terzo, Stefano; The ATLAS collaboration

    2017-01-01

    The entire tracking system of the ATLAS experiment will be replaced during the LHC Phase II shutdown (foreseen to take place around 2025) by an all-silicon detector called the "ITk" (Inner Tracker). The innermost portion of ITk will consist of a pixel detector with five layers in the barrel region and and ring-shaped supports in the endcap regions. It will be instrumented with new sensor and readout electronics technologies to improve the tracking performance and cope with the HL-LHC environment, which will be severe in terms of occupancy and radiation. The total surface area of silicon in the new pixel system could measure up to 14 m$^2$ , depending on the final layout choice, which is expected to take place in early 2017. Several layout options are being investigated at the moment, including some with novel inclined support structures in the barrel-endcap overlap region and others with very long innermost barrel layers. Forward coverage could be as high as $|\\eta| < 4$. Supporting structures will be ...

  17. Phase II Final Scientific/Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Grigg, Reid; McPherson, Brian; Lee, Rober

    2011-08-01

    The Southwest Regional Partnership on Carbon Sequestration (SWP) one of seven regional partnerships sponsored by the U.S. Department of Energy (USDOE) carried out five field pilot tests in its Phase II Carbon Sequestration Demonstration effort, to validate the most promising sequestration technologies and infrastructure concepts, including three geologic pilot tests and two terrestrial pilot programs. This field testing demonstrated the efficacy of proposed sequestration technologies to reduce or offset greenhouse gas emissions in the region. Risk mitigation, optimization of monitoring, verification, and accounting (MVA) protocols, and effective outreach and communication were additional critical goals of these field validation tests. The program included geologic pilot tests located in Utah, New Mexico, Texas, and a region-wide terrestrial analysis. Each geologic sequestration test site was intended to include injection of a minimum of ~75,000 tons/year CO{sub 2}, with minimum injection duration of one year. These pilots represent medium- scale validation tests in sinks that host capacity for possible larger-scale sequestration operations in the future. These validation tests also demonstrated a broad variety of carbon sink targets and multiple value-added benefits, including testing of enhanced oil recovery and sequestration, enhanced coalbed methane production and a geologic sequestration test combined with a local terrestrial sequestration pilot. A regional terrestrial sequestration demonstration was also carried out, with a focus on improved terrestrial MVA methods and reporting approaches specific for the Southwest region.

  18. Design of Phase II Non-inferiority Trials.

    Science.gov (United States)

    Jung, Sin-Ho

    2017-09-01

    With the development of inexpensive treatment regimens and less invasive surgical procedures, we are confronted with non-inferiority study objectives. A non-inferiority phase III trial requires a roughly four times larger sample size than that of a similar standard superiority trial. Because of the large required sample size, we often face feasibility issues to open a non-inferiority trial. Furthermore, due to lack of phase II non-inferiority trial design methods, we do not have an opportunity to investigate the efficacy of the experimental therapy through a phase II trial. As a result, we often fail to open a non-inferiority phase III trial and a large number of non-inferiority clinical questions still remain unanswered. In this paper, we want to develop some designs for non-inferiority randomized phase II trials with feasible sample sizes. At first, we review a design method for non-inferiority phase III trials. Subsequently, we propose three different designs for non-inferiority phase II trials that can be used under different settings. Each method is demonstrated with examples. Each of the proposed design methods is shown to require a reasonable sample size for non-inferiority phase II trials. The three different non-inferiority phase II trial designs are used under different settings, but require similar sample sizes that are typical for phase II trials.

  19. 40 CFR 72.44 - Phase II repowering extensions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Phase II repowering extensions. 72.44... (CONTINUED) PERMITS REGULATION Acid Rain Compliance Plan and Compliance Options § 72.44 Phase II repowering... January 1, 1991 by the Secretary of Energy. (2) A repowering extension does not exempt the owner...

  20. 40 CFR 73.21 - Phase II repowering allowances.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Phase II repowering allowances. 73.21... (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Allowance Allocations § 73.21 Phase II repowering allowances. (a) Repowering allowances. In addition to allowances allocated under § 73.10(b), the Administrator will...

  1. Progress at the La Grande complex phase II in Quebec

    Energy Technology Data Exchange (ETDEWEB)

    Levay, J.; Caron, O.; Parent, L. (Societe d' Energie de la Baie James (SEBJ), Montreal (Canada))

    1993-08-01

    Phase II of the La Grande complex in Quebec, Canada, is now under construction (see Water Power and Dam Construction January 1990 and Handbook 1993). This article gives an update on progress at the schemes that comprise the major elements of Phase II. (author)

  2. The CLASS blazar survey - II. Optical properties

    NARCIS (Netherlands)

    Caccianiga, A; Marcha, MJ; Anton, S; Mack, KH; Neeser, MJ

    2002-01-01

    This paper presents the optical properties of the objects selected in the CLASS blazar survey. Because an optical spectrum is now available for 70 per cent of the 325 sources present in the sample, a spectral classification, based on the appearance of the emission/absorption lines, is possible. A wi

  3. The CLASS blazar survey - II. Optical properties

    NARCIS (Netherlands)

    Caccianiga, A; Marcha, MJ; Anton, S; Mack, KH; Neeser, MJ

    2002-01-01

    This paper presents the optical properties of the objects selected in the CLASS blazar survey. Because an optical spectrum is now available for 70 per cent of the 325 sources present in the sample, a spectral classification, based on the appearance of the emission/absorption lines, is possible. A

  4. A Survey of Phase Change Memory Systems

    Institute of Scientific and Technical Information of China (English)

    夏飞; 蒋德钧; 熊劲; 孙凝晖

    2015-01-01

    As the scaling of applications increases, the demand of main memory capacity increases in order to serve large working set. It is difficult for DRAM (dynamic random access memory) based memory system to satisfy the memory capacity requirement due to its limited scalability and high energy consumption. Compared to DRAM, PCM (phase change memory) has better scalability, lower energy leakage, and non-volatility. PCM memory systems have become a hot topic of academic and industrial research. However, PCM technology has the following three drawbacks: long write latency, limited write endurance, and high write energy, which raises challenges to its adoption in practice. This paper surveys architectural research work to optimize PCM memory systems. First, this paper introduces the background of PCM. Then, it surveys research efforts on PCM memory systems in performance optimization, lifetime improving, and energy saving in detail, respectively. This paper also compares and summarizes these techniques from multiple dimensions. Finally, it concludes these optimization techniques and discusses possible research directions of PCM memory systems in future.

  5. Using phase II data for the analysis of phase III studies: An application in rare diseases.

    Science.gov (United States)

    Wandel, Simon; Neuenschwander, Beat; Röver, Christian; Friede, Tim

    2017-06-01

    Clinical research and drug development in orphan diseases are challenging, since large-scale randomized studies are difficult to conduct. Formally synthesizing the evidence is therefore of great value, yet this is rarely done in the drug-approval process. Phase III designs that make better use of phase II data can facilitate drug development in orphan diseases. A Bayesian meta-analytic approach is used to inform the phase III study with phase II data. It is particularly attractive, since uncertainty of between-trial heterogeneity can be dealt with probabilistically, which is critical if the number of studies is small. Furthermore, it allows quantifying and discounting the phase II data through the predictive distribution relevant for phase III. A phase III design is proposed which uses the phase II data and considers approval based on a phase III interim analysis. The design is illustrated with a non-inferiority case study from a Food and Drug Administration approval in herpetic keratitis (an orphan disease). Design operating characteristics are compared to those of a traditional design, which ignores the phase II data. An analysis of the phase II data reveals good but insufficient evidence for non-inferiority, highlighting the need for a phase III study. For the phase III study supported by phase II data, the interim analysis is based on half of the patients. For this design, the meta-analytic interim results are conclusive and would justify approval. In contrast, based on the phase III data only, interim results are inconclusive and require further evidence. To accelerate drug development for orphan diseases, innovative study designs and appropriate methodology are needed. Taking advantage of randomized phase II data when analyzing phase III studies looks promising because the evidence from phase II supports informed decision-making. The implementation of the Bayesian design is straightforward with public software such as R.

  6. Surveys in differential-algebraic equations II

    CERN Document Server

    Reis, Timo

    2015-01-01

    The present volume comprises survey articles on various fields of Differential-Algebraic Equations (DAEs), which have widespread applications in controlled dynamical systems, especially in mechanical and electrical engineering and a strong relation to (ordinary) differential equations. The individual chapters provide reviews, presentations of the current state of research and new concepts in - Observers for DAEs - DAEs in chemical processes - Optimal control of DAEs - DAEs from a functional-analytic viewpoint - Algebraic methods for DAEs The results are presented in an accessible style, making this book suitable not only for active researchers but also for graduate students (with a good knowledge of the basic principles of DAEs) for self-study.

  7. Pajarito Plateau archaeological surveys and excavations. II

    Energy Technology Data Exchange (ETDEWEB)

    Steen, C R

    1982-04-01

    Los Alamos National Laboratory continues its archaeological program of data gathering and salvage excavations. Sites recently added to the archaeological survey are described, as well as the results of five excavations. Among the more interesting and important discoveries are (1) the apparently well-established local use of anhydrous lime, and (2) a late pre-Columbian use of earlier house sites and middens for garden plots. Evidence indicated that the local puebloan population was the result of an expansion of upper Rio Grande peoples, not an influx of migrants.

  8. BADD phase II: DDS information management architecture

    Science.gov (United States)

    Stephenson, Thomas P.; DeCleene, Brian T.; Speckert, Glen; Voorhees, Harry L.

    1997-06-01

    The DARPA Battlefield Awareness and Data Dissemination (BADD) Phase II Program will provide the next generation multimedia information management architecture to support the warfighter. One goal of this architecture is proactive dissemination of information to the warfighter through strategies such as multicast and 'smart push and pull' designed to minimize latency and make maximum use of available communications bandwidth. Another goal is to support integration of information from widely distributed legacy repositories. This will enable the next generation of battlefield awareness applications to form a common operational view of the battlefield to aid joint service and/or multi-national peacekeeping forces. This paper discusses the approach we are taking to realize such an architecture for BADD. Our architecture and its implementation, known as the Distributed Dissemination Serivces (DDS) are based on two key concepts: a global database schema and an intelligent, proactive caching scheme. A global schema provides a common logical view of the information space in which the warfighter operates. This schema (or subsets of it) is shared by all warfighters through a distributed object database providing local access to all relevant metadata. This approach provides both scalability to a large number of warfighters, and it supports tethered as well as autonomous operations. By utilizing DDS information integration services that provide transparent access to legacy databases, related information from multiple 'stovepipe' systems are now available to battlefield awareness applications. The second key concept embedded in our architecture is an intelligent, hierarchical caching system supported by proactive dissemination management services which push both lightweight and heavyweight data such as imagery and video to warfighters based on their information profiles. The goal of this approach is to transparently and proactively stage data which is likely to be requested by

  9. European cardiac resynchronization therapy survey II: rationale and design.

    Science.gov (United States)

    Dickstein, Kenneth; Normand, Camilla; Anker, Stefan D; Auricchio, Angelo; Blomström, Carina Lundqvist; Lundqvist, Carina Blomström; Bogale, Nigussie; Cleland, John; Filippatos, Gerasimos; Gasparini, Maurizio; Gitt, Anselm; Hindricks, Gerhard; Kuck, Karl-Heinz; Ponikowski, Piotr; Stellbrink, Christoph; Ruschitzka, Frank; Linde, Cecilia

    2015-01-01

    The Cardiac Resynchronization Therapy (CRT) Survey II is a 6 months snapshot survey initiated by two ESC Associations, the European Heart Rhythm Association and the Heart Failure Association, which is designed to describe clinical practice regarding implantation of CRT devices in a broad sample of hospitals in 47 ESC member countries. The large volume of clinical and demographic data collected should reflect current patient selection, implantation, and follow-up practice and provide information relevant for assessing healthcare resource utilization in connection with CRT. The findings of this survey should permit representative benchmarking both nationally and internationally across Europe.

  10. Using phase II data for the analysis of phase III studies: an application in rare diseases

    OpenAIRE

    Wandel, Simon; Neuenschwander, Beat; Friede, Tim; Röver, Christian

    2016-01-01

    Clinical research and drug development in orphan diseases is challenging, since large-scale randomized studies are difficult to conduct. Formally synthesizing the evidence is therefore of great value, yet this is rarely done in the drug approval process. Phase III designs that make better use of phase II data can facilitate drug development in orphan diseases. A Bayesian meta-analytic approach is used to inform the phase III study with phase II data. It is particularly attractive, since uncer...

  11. Savanna ecosystem project: phase I summary and phase II progress

    CSIR Research Space (South Africa)

    Huntely, BJ

    1978-07-01

    Full Text Available A summary of the results of the first phase (mid 1974 to mid 1976) of the South African Savanna Ecosystem Project being undertaken at Nylsvley in the northern Transvaal is presented. Phase I of this ten year study of the structure and functioning...

  12. Spectral Confusion for Cosmological Surveys of Redshifted C II Emission

    Science.gov (United States)

    Kogut, A.; Dwek, E.; Moseley, S. H.

    2015-01-01

    Far-infrared cooling lines are ubiquitous features in the spectra of star-forming galaxies. Surveys of redshifted fine-structure lines provide a promising new tool to study structure formation and galactic evolution at redshifts including the epoch of reionization as well as the peak of star formation. Unlike neutral hydrogen surveys, where the 21 cm line is the only bright line, surveys of redshifted fine-structure lines suffer from confusion generated by line broadening, spectral overlap of different lines, and the crowding of sources with redshift. We use simulations to investigate the resulting spectral confusion and derive observing parameters to minimize these effects in pencilbeam surveys of redshifted far-IR line emission. We generate simulated spectra of the 17 brightest far-IR lines in galaxies, covering the 150-1300 µm wavelength region corresponding to redshifts 0 C II] line and other lines. Although the [C II] line is a principal coolant for the interstellar medium, the assumption that the brightest observed lines in a given line of sight are always [C II] lines is a poor approximation to the simulated spectra once other lines are included. Blind line identification requires detection of fainter companion lines from the same host galaxies, driving survey sensitivity requirements. The observations require moderate spectral resolution 700 < R < 4000 with angular resolution between 20? and 10', sufficiently narrow to minimize confusion yet sufficiently large to include a statistically meaningful number of sources.

  13. Performance of the LAr scintillation veto of Gerda Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Wiesinger, Christoph [Physik-Department and Excellence Cluster Universe, Technische Universitaet Muenchen, James-Franck-Strasse, 85748 Garching (Germany); Collaboration: GERDA-Collaboration

    2016-07-01

    Gerda is an experiment to search for the neutrinoless double beta decay in {sup 76}Ge. Results of Phase I have been published in summer 2013 and Gerda has been upgraded to Phase II. To reach the aspired background index of ∝10{sup -3} cts/(keV.kg.yr) for Phase II active background-suppression techniques are applied, including an active liquid argon (LAr) veto. It has been demonstrated with the LArGe test facility that the detection of argon scintillation light can be used to effectively suppress background events in the germanium detectors, which simultaneously deposit energy in the LAr. The light instrumentation consisting of photomultiplier tubes (PMT) and wavelength-shifting fibers connected to silicon photomultipliers (SiPM) has been installed in Gerda. In this talk the low background design of the LAr veto and its performance during Phase II start-up is reported.

  14. ENERGY DEPOSITION STUDIES FOR POSSIBLE INNOVATIVE PHASE II COLLIMATOR DESIGNS

    CERN Document Server

    Lari, L; Brugger, M; Cerutti, F; Ferrari, A; Vlachoudis, V; Weiler, T

    2009-01-01

    Due to the known limitations of Phase I LHC collimators in stable physics conditions, the LHC collimation system will be complemented by additional 30 Phase II collimators. The Phase II collimation system is designed to improve cleaning efficiency and to minimize the collimator-induced impedance with the main function of protecting the Super Conducting (SC) magnets from quenching due to beam particle losses. To fulfil these requirements, different possible innovative collimation designs were taken in consideration. Advanced jaw materials, including new composite materials (e.g. Cu–Diamond), jaw SiC insertions, coating foil, in-jaw instrumentation (e.g. BPM) and improved mechanical robustness of the jaw are the main features of these new promising Phase II collimator designs developed at CERN. The FLUKA Monte Carlo code is extensively used to evaluate the behavior of these collimators in the most radioactive areas of LHC, supporting the mechanical integration. These studies aim to identify the possible criti...

  15. Energy Deposition Studies for Possible Innovative Phase II Collimator Designs

    CERN Document Server

    Lari, L; Brugger, M; Cerutti, F; Ferrari, A; Vlachoudis, V; Weiler, T

    2010-01-01

    Due to the known limitations of Phase I LHC collimators in stable physics conditions, the LHC collimation system will be complemented by additional 30 Phase II collimators. The Phase II collimation system is designed to improve cleaning efficiency and to minimize the collimator-induced impedance with the main function of protecting the Super Conducting (SC) magnets from quenching due to beam particle losses. To fulfil these requirements, different possible innovative collimation designs were taken in consideration. Advanced jaw materials, including new composite materials (e.g. Cu–Diamond), jaw SiC insertions, coating foil, in-jaw instrumentation (e.g. BPM) and improved mechanical robustness of the jaw are the main features of these new promising Phase II collimator designs developed at CERN. The FLUKA Monte Carlo code is extensively used to evaluate the behavior of these collimators in the most radioactive areas of LHC, supporting the mechanical integration. These studies aim to identify the possible criti...

  16. Yakima River Basin Phase II Fish Screen Evaluations, 2002

    Energy Technology Data Exchange (ETDEWEB)

    Carter, Jessica A.; McMichael, Geoffrey A.; Chamness, Mickie A.

    2003-03-01

    In 2002, the Pacific Northwest National Laboratory evaluated 23 Phase II fish screen sites in the Yakima River Basin as part of a multi-year project for the Bonneville Power Administration on the effectiveness of fish screening devices. Pacific Northwest National Laboratory collected data to determine whether velocities in front of the screens and in the bypasses met National Marine Fisheries Service criteria to promote safe and timely fish passage and whether bypass outfall conditions allowed fish to safely return to the river. In addition, Pacific Northwest National Laboratory conducted underwater video surveys to evaluate the environmental and operational conditions of the screen sites with respect to fish passage. Based on evaluations in 2002, PNNL concluded that: (1) In general, water velocity conditions at the screen sites met fish passage criteria set by the National Marine Fisheries Service. (2) Conditions at most facilities would be expected to provide for safe juvenile fish passage. (3) Conditions at some facilities indicate that operation and/or maintenance should be modified to increase safe juvenile fish passage. (4) Automated cleaning brushes generally functioned properly; chains and other moving parts were typically well greased and operative. (5) Removal of sediment buildup and accumulated leafy and woody debris should be improved at some sites.

  17. ARAC results from phase II of the European tracer experiment

    Energy Technology Data Exchange (ETDEWEB)

    Pace, J.C.; Nasstrom, J.S.

    1997-07-01

    A comparison is provided of the results of calculations by the Atmospheric Release Advisory Capability (ARAC) during two phases of the European Tracer Experiment (ETEX). In phase I of ETEX, participants generated predictions in real time of the concentration of inert tracer gases released from a site in Western France. Each participating group based their predictions on the meteorological data they had available. In phase II, all participants were required to recalculate predictions based on the same meteorological data, which was generated and supplied by the European Centre for Medium- Range Weather Forecasts (ECMWF). ARAC used ECMWF data and also made additional changes to its model configuration,, with the result that ARAC`s accuracy during phase II was much better than for phase I. Experiments described in this paper examine the effect of each of these changes, and show that each change contributed to the improvement.

  18. Measured Aperture-Array Noise Temperature of the Mark II Phased Array Feed for ASKAP

    CERN Document Server

    Chippendale, A P; Beresford, R J; Hampson, G A; Shaw, R D; Hayman, D B; Macleod, A; Forsyth, A R; Hay, S G; Leach, M; Cantrall, C; Brothers, M L; Hotan, A W

    2015-01-01

    We have measured the aperture-array noise temperature of the first Mk. II phased array feed that CSIRO has built for the Australian Square Kilometre Array Pathfinder telescope. As an aperture array, the Mk. II phased array feed achieves a beam equivalent noise temperature less than 40 K from 0.78 GHz to 1.7 GHz and less than 50 K from 0.7 GHz to 1.8 GHz for a boresight beam directed at the zenith. We believe these are the lowest reported noise temperatures over these frequency ranges for ambient-temperature phased arrays. The measured noise temperature includes receiver electronics noise, ohmic losses in the array, and stray radiation from sidelobes illuminating the sky and ground away from the desired field of view. This phased array feed was designed for the Australian Square Kilometre Array Pathfinder to demonstrate fast astronomical surveys with a wide field of view for the Square Kilometre Array.

  19. SPECTRAL CONFUSION FOR COSMOLOGICAL SURVEYS OF REDSHIFTED C II EMISSION

    Energy Technology Data Exchange (ETDEWEB)

    Kogut, A.; Dwek, E.; Moseley, S. H., E-mail: Alan.J.Kogut@nasa.gov [Code 665, Goddard Space Flight Center, Greenbelt, MD 20771 (United States)

    2015-06-20

    Far-infrared cooling lines are ubiquitous features in the spectra of star-forming galaxies. Surveys of redshifted fine-structure lines provide a promising new tool to study structure formation and galactic evolution at redshifts including the epoch of reionization as well as the peak of star formation. Unlike neutral hydrogen surveys, where the 21 cm line is the only bright line, surveys of redshifted fine-structure lines suffer from confusion generated by line broadening, spectral overlap of different lines, and the crowding of sources with redshift. We use simulations to investigate the resulting spectral confusion and derive observing parameters to minimize these effects in pencil-beam surveys of redshifted far-IR line emission. We generate simulated spectra of the 17 brightest far-IR lines in galaxies, covering the 150–1300 μm wavelength region corresponding to redshifts 0 < z < 7, and develop a simple iterative algorithm that successfully identifies the 158 μm [C ii] line and other lines. Although the [C ii] line is a principal coolant for the interstellar medium, the assumption that the brightest observed lines in a given line of sight are always [C ii] lines is a poor approximation to the simulated spectra once other lines are included. Blind line identification requires detection of fainter companion lines from the same host galaxies, driving survey sensitivity requirements. The observations require moderate spectral resolution 700 < R < 4000 with angular resolution between 20″ and 10′, sufficiently narrow to minimize confusion yet sufficiently large to include a statistically meaningful number of sources.

  20. Spectral Confusion for Cosmological Surveys of Redshifted C II Emission

    Science.gov (United States)

    Kogut, A.; Dwek, E.; Moseley, S. H.

    2015-01-01

    Far-infrared cooling lines are ubiquitous features in the spectra of star-forming galaxies. Surveys of redshifted fine-structure lines provide a promising new tool to study structure formation and galactic evolution at redshifts including the epoch of reionization as well as the peak of star formation. Unlike neutral hydrogen surveys, where the 21 cm line is the only bright line, surveys of redshifted fine-structure lines suffer from confusion generated by line broadening, spectral overlap of different lines, and the crowding of sources with redshift. We use simulations to investigate the resulting spectral confusion and derive observing parameters to minimize these effects in pencilbeam surveys of redshifted far-IR line emission. We generate simulated spectra of the 17 brightest far-IR lines in galaxies, covering the 150-1300 µm wavelength region corresponding to redshifts 0 < z < 7, and develop a simple iterative algorithm that successfully identifies the 158 µm [C II] line and other lines. Although the [C II] line is a principal coolant for the interstellar medium, the assumption that the brightest observed lines in a given line of sight are always [C II] lines is a poor approximation to the simulated spectra once other lines are included. Blind line identification requires detection of fainter companion lines from the same host galaxies, driving survey sensitivity requirements. The observations require moderate spectral resolution 700 < R < 4000 with angular resolution between 20? and 10', sufficiently narrow to minimize confusion yet sufficiently large to include a statistically meaningful number of sources.

  1. Conditionally unbiased estimation in phase II/III clinical trials with early stopping for futility

    OpenAIRE

    Kimani, Peter K.; Todd, Susan; Stallard, Nigel

    2013-01-01

    Seamless phase II/III clinical trials combine traditional phases II and III into a single trial that is conducted in two stages, with stage 1 used to answer phase II objectives such as treatment selection and stage 2 used for the confirmatory analysis, which is a phase III objective. Although seamless phase II/III clinical trials are efficient because the confirmatory analysis includes phase II data from stage 1, inference can pose statistical challenges. In this paper, we consider point esti...

  2. HERSCHEL GALACTIC PLANE SURVEY OF [N ii] FINE STRUCTURE EMISSION

    Energy Technology Data Exchange (ETDEWEB)

    Goldsmith, Paul F.; Yıldız, Umut A.; Langer, William D.; Pineda, Jorge L., E-mail: Paul.F.Goldsmith@jpl.nasa.gov [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States)

    2015-12-01

    We present the first large-scale high angular resolution survey of ionized nitrogen in the Galactic Plane through emission of its two fine structure transitions ([N ii]) at 122 and 205 μm. The observations were largely obtained with the PACS instrument onboard the Herschel Space Observatory. The lines of sight were in the Galactic plane, following those of the Herschel OTKP project GOT C+. Both lines are reliably detected at the 10{sup −8}–10{sup −7} Wm{sup −2} sr{sup −1} level over the range –60° ≤ l ≤ 60°. The rms of the intensity among the 25 PACS spaxels of a given pointing is typically less than one third of the mean intensity, showing that the emission is extended. [N ii] is produced in gas in which hydrogen is ionized, and collisional excitation is by electrons. The ratio of the two fine structure transitions provides a direct measurement of the electron density, yielding n(e) largely in the range 10–50 cm{sup −3} with an average value of 29 cm{sup −3} and N{sup +} column densities 10{sup 16}–10{sup 17} cm{sup −2}. [N ii] emission is highly correlated with that of [C ii], and we calculate that between 1/3 and 1/2 of the [C ii] emission is associated with the ionized gas. The relatively high electron densities indicate that the source of the [N ii] emission is not the warm ionized medium (WIM), which has electron densities more than 100 times smaller. Possible origins of the observed [N ii] include the ionized surfaces of dense atomic and molecular clouds, the extended low-density envelopes of H ii regions, and low-filling factor high-density fluctuations of the WIM.

  3. Status of the Transneptunian Automated Occultation Survey (TAOS II)

    Science.gov (United States)

    Reyes-Ruiz, Mauricio

    2014-11-01

    TAOS II is a next generation occultation survey with the goal of measuring the size distribution of the small objects (diameters between 0.5 and 30 km) in the Kuiper Belt. The project is a collaboration between the Academia Sinica Institute of Astronomy and Astrophysics, the Universidad Nacional Autonoma de Mexico, and the Harvard-Smithsonian Center for Astrophysics, The survey will operate three 1.3 m telescopes at San Pedro Martir Observatory in Baja California, Mexico. Each telescope will be equipped with a custom camera comprising a focal plane array of CMOS imagers. Each camera will be capable of reading out image data from 10,000 stars at a cadence of 20 Hz. All telescopes will monitor the same set of stars simultaneously to search for coincident occultation events while minimizing the false positive rate. This poster describes the project and reports on the progress of the development of the survey infrastructure.

  4. Adaptive Processing Experiment (APE) Phase II

    Science.gov (United States)

    1976-05-01

    FI LTE.R -R 9 0R L• k k.9 0Ms EPPMR PHASE AMPL,I (t) ( r)GR•S ) (Zi) ( flt3 POWfER) (DEGRFES) (Ob) tF(IpE A0TfR bFt-Iý- E. AF tLk EIJN• AFTER , ---,,1...t.In I ,4P -. 3/ ,a?-.•O*O9 -34,57 o1o)110O 0 .- . 614 . - " 13,𔃼h a w, 3b " 3 v5• S -01 ,19 -tgo (19.52 TUTAI 87 ,, ,21 .11 6,, .71 -34,,74SNET PF...38,95 a08 *t0 70,o so0 󈧽 -sob D8• -Sq,74 -37,5q 007 614 € 75,t) .7n ,76 .,tok) -.36,03 -37a01 ’nh o16 80,0 .76 o0P- u,. , () -32, 1,2• -36,79 aO b

  5. The Green Bank Telescope Galactic H II Region Discovery Survey

    CERN Document Server

    Bania, T M; Balser, Dana S; Rood, R T

    2010-01-01

    We discovered a large population of previously unknown Galactic H II regions by using the Green Bank Telescope to detect their hydrogen radio recombination line emission. Since recombination lines are optically thin at 3 cm wavelength, we can detect H II regions across the entire Galactic disk. Our targets were selected based on spatially coincident 24 micron and 21 cm continuum emission. For the Galactic zone -16 deg < L_gal < 67 deg and abs(B_gal) < 1 deg, we detected 602 discrete recombination line components from 448 lines of sight, 95% of the sample targets, which more than doubles the number of known H II regions in this part of the Milky Way. We found 25 new first quadrant nebulae with negative LSR velocities, placing them beyond the Solar orbit. Because we can detect all nebulae inside the Solar orbit that are ionized by O-stars, the Discovery Survey targets, when combined with existing H II region catalogs, give a more accurate census of Galactic H II regions and their properties. The distri...

  6. 78 FR 8184 - DEEPWATER HORIZON Oil Spill; Final Phase II Early Restoration Plan and Environmental Review

    Science.gov (United States)

    2013-02-05

    ... Early Restoration Plan and Environmental Review (Phase II ERP/ER) describing the second set of... availability of the Phase II ERP/ER. ADDRESSES: Obtaining Documents: You may download the Phase II ERP/ER and... the Phase II ERP/ER at any of the public repositories listed at...

  7. Performance of BEGe detectors for GERDA Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Lazzaro, Andrea [Physik-Department E15, Technische Universitaet Muenchen (Germany); Collaboration: GERDA-Collaboration

    2015-07-01

    After the end of the data-taking for GERDA Phase I, the apparatus has been upgraded to fulfill the requirements of the second phase. Phase II sensitivity will be driven by 30 custom made BEGe detectors. This detectors are now available and can be operated in phaseII configuration in the GERDA cryostat together with the liquid argon scintillation veto. The performances of BEGe detectors in liquid argon are presented in this talk. Besides the spectroscopy capability, the focus will be placed on the expectations in terms of background rejection via pulse shape discrimination (PSD). In particular the main goal the BEGe's pulse shape analysis is to discriminate surface events produced by beta emitters (e.g. {sup 42}K) present in the liquid Ar.

  8. Measured Sensitivity of the First Mark II Phased Array Feed on an ASKAP Antenna

    CERN Document Server

    Chippendale, A P; Beresford, R J; Hampson, G A; Macleod, A; Shaw, R D; Brothers, M L; Cantrall, C; Forsyth, A R; Hay, S G; Leach, M

    2015-01-01

    This paper presents the measured sensitivity of CSIRO's first Mk. II phased array feed (PAF) on an ASKAP antenna. The Mk. II achieves a minimum system-temperature-over-efficiency $T_\\mathrm{sys}/\\eta$ of 78 K at 1.23 GHz and is 95 K or better from 835 MHz to 1.8 GHz. This PAF was designed for the Australian SKA Pathfinder telescope to demonstrate fast astronomical surveys with a wide field of view for the Square Kilometre Array (SKA).

  9. Type IA supernova spectroscopy analysis of Sloan Digital Sky Survey II - Supernova Survey

    Science.gov (United States)

    Zheng, Chen

    2009-06-01

    Supernovae (SNe) have played an important role in the recent dramatic development of observational cosmology. They possess homogeneous observable properties, and thus approximate "standard candles", allowing them to be precise, luminosity distance indicators. Over the last decade, the observed sample of supernovae (SNe) has increased by more than an order of magnitude. Further advances will no longer be limited by statistical errors, but rather by the control of systematic uncertainties, associated with source diversity and evolution. Over 500 SNe Ia have been discovered by the Sloan Digital Sky Survey (SDSS) -- II SN Survey during the three fall seasons from 2005 to 2007. We combine spectroscopic and photometric data to explore reducing these systematic errors. One challenge is to remove accurately the host galaxy light from the observed spectra. We have developed an effective host-subtraction tool using a composite color-constrained PCA+template-fitting program. We have applied this technique to more than 700 spectra from SNe with redshifts up to 0.4 obtained from the SDSS-II SN Survey and more than 200 spectra from low-z SNe at redshifts less than 0.01 obtained from the Center for Astrophysics (CfA) SN archive. We have also developed an automatic method to quantify spectral features of SNe Ia and applied it to the CfA and SDSS-II samples. By comparing the time series of the spectral features between these two samples, we have found no sign of cosmological evolution. We have, however, found evidence for luminosity-dependent differences in the Mg II 4300, Si II 4000, Si II 5800, and Si II 6150 lines. This should be useful for cosmological studies.

  10. Beach monitoring project Sand Key Phase II Beach nourishment program (North Redington Beach and Redington Shores) Post-Nourishment Report Part II Offshore Profiles and Wave Data

    OpenAIRE

    1989-01-01

    This study presents the third post-nourishment survey (January 1989) results for the Sand Key Phase II beach nourishment project carried out in June, 1988. The monitoring program to this beach nourishment project is a joint effort between the University of South Florida and University of Florida. The field surveys include a total of 26 profiles, encompassing approximately 3 miles of shoreline extending from DNR R-96 to R-1ll. The total calculated volume loss of sand in the n...

  11. The SafeBoosC phase II clinical trial

    DEFF Research Database (Denmark)

    Riera, Joan; Hyttel-Sorensen, Simon; Bravo, María Carmen

    2016-01-01

    BACKGROUND: The SafeBoosC phase II randomised clinical trial recently demonstrated the benefits of a combination of cerebral regional tissue oxygen saturation (rStO2) by near-infrared spectroscopy (NIRS) and a treatment guideline to reduce the oxygen imbalance in extremely preterm infants. AIMS...

  12. The SafeBoosC Phase II Randomised Clinical Trial

    DEFF Research Database (Denmark)

    Pellicer, Adelina; Greisen, Gorm; Benders, Manon

    2013-01-01

    Near-infrared spectroscopy-derived regional tissue oxygen saturation of haemoglobin (rStO2) reflects venous oxygen saturation. If cerebral metabolism is stable, rStO2 can be used as an estimate of cerebral oxygen delivery. The SafeBoosC phase II randomised clinical trial hypothesises that the bur...

  13. 40 CFR 790.52 - Phase II test rule.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 31 2010-07-01 2010-07-01 true Phase II test rule. 790.52 Section 790.52 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT... Federal Register requesting comments on the ability of the proposed study plan to ensure that data from...

  14. The SafeBoosC phase II clinical trial

    DEFF Research Database (Denmark)

    Riera, Joan; Hyttel-Sorensen, Simon; Bravo, María Carmen

    2016-01-01

    BACKGROUND: The SafeBoosC phase II randomised clinical trial recently demonstrated the benefits of a combination of cerebral regional tissue oxygen saturation (rStO2) by near-infrared spectroscopy (NIRS) and a treatment guideline to reduce the oxygen imbalance in extremely preterm infants. AIMS: ...

  15. Probability of success for phase III after exploratory biomarker analysis in phase II.

    Science.gov (United States)

    Götte, Heiko; Kirchner, Marietta; Sailer, Martin Oliver

    2017-02-23

    The probability of success or average power describes the potential of a future trial by weighting the power with a probability distribution of the treatment effect. The treatment effect estimate from a previous trial can be used to define such a distribution. During the development of targeted therapies, it is common practice to look for predictive biomarkers. The consequence is that the trial population for phase III is often selected on the basis of the most extreme result from phase II biomarker subgroup analyses. In such a case, there is a tendency to overestimate the treatment effect. We investigate whether the overestimation of the treatment effect estimate from phase II is transformed into a positive bias for the probability of success for phase III. We simulate a phase II/III development program for targeted therapies. This simulation allows to investigate selection probabilities and allows to compare the estimated with the true probability of success. We consider the estimated probability of success with and without subgroup selection. Depending on the true treatment effects, there is a negative bias without selection because of the weighting by the phase II distribution. In comparison, selection increases the estimated probability of success. Thus, selection does not lead to a bias in probability of success if underestimation due to the phase II distribution and overestimation due to selection cancel each other out. We recommend to perform similar simulations in practice to get the necessary information about the risk and chances associated with such subgroup selection designs.

  16. Performance of the LAr scintillation veto of GERDA Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Wiesinger, Christoph [Technische Universitaet Muenchen, Physik Dept. E15, James-Franck-Strasse, 85748 Garching (Germany); Collaboration: GERDA-Collaboration

    2015-07-01

    Gerda is an experiment to search for the neutrinoless double beta decay in {sup 76}Ge. Results of Phase I have been published in summer 2013 and Gerda is upgraded to Phase II. To reach the aspired background index of ≤ 10{sup -3} cts/(keV.kg.yr) for Phase II active background-suppression techniques are applied, including an active liquid argon (LAr) veto. It has been demonstrated with the LArGe test facility that the detection of argon scintillation light can be used to effectively suppress background events in the germanium, which simultaneously deposit energy in the LAr. The light instrumentation consisting of photomultiplier tubes (PMT) and wavelength-shifting fibers connected to silicon multipliers (SiPM) has been installed in Gerda. In this talk the low background design of the LAr veto and its performance during the commissioning runs are reported.

  17. 78 FR 30951 - SBIR/STTR Phase I to Phase II Transition Benchmarks

    Science.gov (United States)

    2013-05-23

    ... ADMINISTRATION SBIR/STTR Phase I to Phase II Transition Benchmarks AGENCY: U.S. Small Business Administration...; Amended. SUMMARY: The Small Business Administration (SBA) is soliciting comments on proposed amendments to... Director, Office of Innovation, Small Business Administration, 409 Third Street SW., Washington, DC...

  18. NEWLY IDENTIFIED EXTENDED GREEN OBJECTS (EGOs) FROM THE SPITZER GLIMPSE II SURVEY. II. MOLECULAR CLOUD ENVIRONMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Chen Xi; Gan Conggui; Shen Zhiqiang [Key Laboratory for Research in Galaxies and Cosmology, Shanghai Astronomical Observatory, Chinese Academy of Sciences, Shanghai 200030 (China); Ellingsen, Simon P.; Titmarsh, Anita [School of Mathematics and Physics, University of Tasmania, Hobart, Tasmania (Australia); He Jinhua, E-mail: chenxi@shao.ac.cn [Key Laboratory for the Structure and Evolution of Celestial Objects, Yunnan Astronomical Observatory/National Astronomical Observatory, Chinese Academy of Sciences, P.O. Box 110, Kunming 650011, Yunnan Province (China)

    2013-06-01

    We have undertaken a survey of molecular lines in the 3 mm band toward 57 young stellar objects using the Australia Telescope National Facility Mopra 22 m radio telescope. The target sources were young stellar objects with active outflows (extended green objects (EGOs)) newly identified from the GLIMPSE II survey. We observe a high detection rate (50%) of broad line wing emission in the HNC and CS thermal lines, which combined with the high detection rate of class I methanol masers toward these sources (reported in Paper I) further demonstrates that the GLIMPSE II EGOs are associated with outflows. The physical and kinematic characteristics derived from the 3 mm molecular lines for these newly identified EGOs are consistent with these sources being massive young stellar objects with ongoing outflow activity and rapid accretion. These findings support our previous investigations of the mid-infrared properties of these sources and their association with other star formation tracers (e.g., infrared dark clouds, methanol masers and millimeter dust sources) presented in Paper I. The high detection rate (64%) of the hot core tracer CH{sub 3}CN reveals that the majority of these new EGOs have evolved to the hot molecular core stage. Comparison of the observed molecular column densities with predictions from hot core chemistry models reveals that the newly identified EGOs from the GLIMPSE II survey are members of the youngest hot core population, with an evolutionary time scale of the order of 10{sup 3} yr.

  19. THE NEXT GENERATION TRANSIT SURVEY PROTOTYPING PHASE

    Directory of Open Access Journals (Sweden)

    J. McCormac

    2014-01-01

    Full Text Available El Next Generation Transit Survey (NGTS es un nuevo sondeo d e exoplanetas transitantes de campo amplio que tiene como objetivo descubrir exoplanetas del tama ̃no d e Neptuno y super-Tierras entorno a estrellas brillantes ( V < 13 cercanas. NGTS consiste de un arreglo de 12 telescopios o perados rob ́oticamente observando en la banda de 600 − 900 nm. NGTS sondear ́a m ́as de cinco veces el n ́umero de estre llas, con V < 13, que Kepler y por lo tanto proveer ́a los objetivos m ́as brillantes para s er caracterizados con instrumentaci ́on existente y futura (VLT, E-ELT y JWST. En 2009/10 un prototipo del NGTS f ue probado en La Palma, comprobando que un sistema as ́ı puede alcanzar nuestros objetivos de fot ometr ́ıa estelar esencialmente limitada s ́olo por el ruido blanco. Los resultados son resumidos aqu ́ı. NGTS se al imenta de la experiencia del proyecto SuperWASP, que, por muchos a ̃nos, ha liderado la detecci ́on terrestre d e exoplanetas transitantes.

  20. The Sloan Digital Sky Survey-II Supernova Survey: Technical Summary

    Energy Technology Data Exchange (ETDEWEB)

    Frieman, Joshua A.; /Fermilab /KICP, Chicago /Chicago U., Astron. Astrophys. Ctr.; Bassett, Bruce; /Cape Town U. /South African Astron. Observ.; Becker, Andrew; /Washington; Choi, Changsu; /Seoul Natl. U.; Cinabro, David; /Wayne State U.; DeJongh, Don Frederic; /Fermilab; Depoy, Darren L.; /Ohio State U.; Doi, Mamoru; /Tokyo U.; Garnavich, Peter M.; /Notre Dame U.; Hogan, Craig J.; /Washington U., Seattle, Astron. Dept.; Holtzman, Jon; /New Mexico State U.; Im, Myungshin; /Seoul Natl. U.; Jha, Saurabh; /Stanford U., Phys. Dept.; Konishi, Kohki; /Tokyo U.; Lampeitl, Hubert; /Baltimore, Space Telescope Sci.; Marriner, John; /Fermilab; Marshall, Jennifer L.; /Ohio State U.; McGinnis,; /Fermilab; Miknaitis, Gajus; /Fermilab; Nichol, Robert C.; /Portsmouth U.; Prieto, Jose Luis; /Ohio State U. /Rochester Inst. Tech. /Stanford U., Phys. Dept. /Pennsylvania U.

    2007-09-14

    The Sloan Digital Sky Survey-II (SDSS-II) has embarked on a multi-year project to identify and measure light curves for intermediate-redshift (0.05 < z < 0.35) Type Ia supernovae (SNe Ia) using repeated five-band (ugriz) imaging over an area of 300 sq. deg. The survey region is a stripe 2.5 degrees wide centered on the celestial equator in the Southern Galactic Cap that has been imaged numerous times in earlier years, enabling construction of a deep reference image for discovery of new objects. Supernova imaging observations are being acquired between 1 September and 30 November of 2005-7. During the first two seasons, each region was imaged on average every five nights. Spectroscopic follow-up observations to determine supernova type and redshift are carried out on a large number of telescopes. In its first two three-month seasons, the survey has discovered and measured light curves for 327 spectroscopically confirmed SNe Ia, 30 probable SNe Ia, 14 confirmed SNe Ib/c, 32 confirmed SNe II, plus a large number of photometrically identified SNe Ia, 94 of which have host-galaxy spectra taken so far. This paper provides an overview of the project and briefly describes the observations completed during the first two seasons of operation.

  1. The Sloan Digital Sky Survey-II Supernova Survey: Technical Summary

    CERN Document Server

    Frieman, Joshua A; Becker, A; Choi, C; Cinabro, D; De Jongh, F; Depoy, D L; Dilday, B; Doi, M; Garnavich, P M; Hogan, C J; Holtzman, J; Im, M; Jha, S; Kessler, R; Konishi, K; Lampeitl, H; Marriner, J; Marshall, J L; McGinnis, D; Miknaitis, G; Nichol, R C; Prieto, J L; Riess, A G; Richmond, M W; Romani, R; Sako, M; Schneider, D P; Smith, M; Takanashi, N; Tokita, K; van der Heyden, K; Yasuda, N; Zheng, C; Adelman-McCarthy, J; Annis, J; Assef, R J; Barentine, J; Bender, R; Blandford, R D; Boroski, W N; Bremer, M; Brewington, H; Collins, C A; Crotts, A; Dembicky, J; Eastman, J; Edge, A; Edmondson, E; Elson, E; Eyler, M E; Filippenko, A V; Foley, R J; Frank, S; Goobar, A; Gueth, T; Gunn, J E; Harvanek, M; Hopp, U; Ihara, Y; Ivezić, Ž; Kahn, S; Kaplan, J; Kent, S; Ketzeback, W; Kleinman, S J; Kollatschny, W; Kron, R G; Krzesiński, J; Lamenti, D; Leloudas, G; Lin, H; Long, D C; Lucey, J; Lupton, R H; Malanushenko, E; Malanushenko, V; McMillan, R J; Méndez, J; Morgan, C W; Morokuma, T; Nitta, A; Ostman, L; Pan, K; Rockosi, C M; Romer, A K; Ruiz-Lapuente, P; Saurage, G; Schlesinger, K; Snedden, S A; Sollerman, J; Stoughton, C; Stritzinger, M; Subba-Rao, M; Tucker, D; Väisänen, P; Watson, L C; Watters, S; Wheeler, J C; Yanny, B; York, D

    2007-01-01

    The Sloan Digital Sky Survey-II (SDSS-II) has embarked on a multi-year project to identify and measure light curves for intermediate-redshift (0.05 < z < 0.35) Type Ia supernovae (SNe Ia) using repeated five-band (ugriz) imaging over an area of 300 sq. deg. The survey region is a stripe 2.5 degrees wide centered on the celestial equator in the Southern Galactic Cap that has been imaged numerous times in earlier years, enabling construction of a deep reference image for discovery of new objects. Supernova imaging observations are being acquired between 1 September and 30 November of 2005-7. During the first two seasons, each region was imaged on average every five nights. Spectroscopic follow-up observations to determine supernova type and redshift are carried out on a large number of telescopes. In its first two three-month seasons, the survey has discovered and measured light curves for 327 spectroscopically confirmed SNe Ia, 30 probable SNe Ia, 14 confirmed SNe Ib/c, 32 confirmed SNe II, plus a large ...

  2. The Sloan Digital Sky Survey-II Supernova Survey: Technical Summary

    Energy Technology Data Exchange (ETDEWEB)

    Frieman, Joshua A.; /Fermilab /KICP, Chicago /Chicago U., Astron. Astrophys. Ctr.; Bassett, Bruce; /Cape Town U. /South African Astron. Observ.; Becker, Andrew; /Washington; Choi, Changsu; /Seoul Natl. U.; Cinabro, David; /Wayne State U.; DeJongh, Don Frederic; /Fermilab; Depoy, Darren L.; /Ohio State U.; Doi, Mamoru; /Tokyo U.; Garnavich, Peter M.; /Notre Dame U.; Hogan, Craig J.; /Washington U., Seattle, Astron. Dept.; Holtzman, Jon; /New Mexico State U.; Im, Myungshin; /Seoul Natl. U.; Jha, Saurabh; /Stanford U., Phys. Dept.; Konishi, Kohki; /Tokyo U.; Lampeitl, Hubert; /Baltimore, Space Telescope Sci.; Marriner, John; /Fermilab; Marshall, Jennifer L.; /Ohio State U.; McGinnis,; /Fermilab; Miknaitis, Gajus; /Fermilab; Nichol, Robert C.; /Portsmouth U.; Prieto, Jose Luis; /Ohio State U. /Rochester Inst. Tech. /Stanford U., Phys. Dept. /Pennsylvania U.

    2007-09-14

    The Sloan Digital Sky Survey-II (SDSS-II) has embarked on a multi-year project to identify and measure light curves for intermediate-redshift (0.05 < z < 0.35) Type Ia supernovae (SNe Ia) using repeated five-band (ugriz) imaging over an area of 300 sq. deg. The survey region is a stripe 2.5 degrees wide centered on the celestial equator in the Southern Galactic Cap that has been imaged numerous times in earlier years, enabling construction of a deep reference image for discovery of new objects. Supernova imaging observations are being acquired between 1 September and 30 November of 2005-7. During the first two seasons, each region was imaged on average every five nights. Spectroscopic follow-up observations to determine supernova type and redshift are carried out on a large number of telescopes. In its first two three-month seasons, the survey has discovered and measured light curves for 327 spectroscopically confirmed SNe Ia, 30 probable SNe Ia, 14 confirmed SNe Ib/c, 32 confirmed SNe II, plus a large number of photometrically identified SNe Ia, 94 of which have host-galaxy spectra taken so far. This paper provides an overview of the project and briefly describes the observations completed during the first two seasons of operation.

  3. OSAS Surgery and Postoperative Discomfort: Phase I Surgery versus Phase II Surgery

    Directory of Open Access Journals (Sweden)

    Giulio Gasparini

    2015-01-01

    Full Text Available Introduction. This study aims to investigate the reasons that discourage the patients affected by OSAS to undergo orthognathic surgery and compares the postoperative discomfort of phase I (soft tissue surgery and phase II (orthognathic surgery procedures for treatment of OSAS. Material and Methods. A pool of 46 patients affected by OSAS was divided into two groups: “surgery patients” who accepted surgical treatments of their condition and “no surgery patients” who refused surgical procedures. The “surgery patients” group was further subdivided into two arms: patients who accepted phase I procedures (IP and those who accepted phase II (IIP. To better understand the motivations behind the refusal of II phase procedures, we asked the patients belonging to both the IP group and “no surgery” group to indicate the main reason that influenced their decision to avoid II phase procedures. We also monitored and compared five parameters of postoperative discomfort: pain, painkiller assumption, length of hospitalization, foreign body sensation, and diet assumption following IP and IIP procedures. Results. The main reason to avoid IIP procedures was the concern of a more severe postoperative discomfort. Comparison of the postoperative discomfort following IP versus IIP procedures showed that the former scored worse in 4 out of 5 parameters analyzed. Conclusion. IIP procedures produce less postoperative discomfort. IIP procedures, namely, orthognathic surgery, should be the first choice intervention in patients affected by OSAS and dentoskeletal malformation.

  4. Microbial Dark Matter Phase II: Stepping deeper into unknown territory

    Energy Technology Data Exchange (ETDEWEB)

    Jarett, Jessica; Dunfield, Peter; Peura, Sari; Wielen, Paul van der; Hedlund, Brian; Elshahed, Mostafa; Kormas, Konstantinos; Stott, Andreas Teske8, Matt; Birkeland, Nils-Kare; Zhang, Chuanlun; Rengefors, Karin; Lindemann, Stephen; Ravin, Nikolai V.; Spear, John; Hallam, Steven; Crowe, Sean; Steele, Jillian; Goudeau, Danielle; Malmstrom, Rex; Kyrpides, Nikos; Stepanauskas, Ramunas; Woyke, Tanja

    2014-10-27

    Currently available microbial genomes are of limited phylogenetic breadth due to our historical inability to cultivate most microorganisms in the laboratory. The first phase of the Microbial Dark Matter project used single-cell genomics to sequence 201 single cells from uncultivated lineages, and was able to resolve new superphyla and reveal novel metabolic features in bacteria and archaea. However, many fundamental questions about the evolution and function of microbes remain unanswered, and many candidate phyla remain uncharacterized. Phase II of the Microbial Dark Matter project will target candidate phyla with no sequenced representatives at a variety of new sites using a combination of single-cell sequencing and shotgun metagenomics approaches.

  5. Egyptian wind energy resources study. Phase II. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Hughes, W.L.

    1979-11-01

    The data gathered in Egypt in Phase I of the program indicated favorable wind energy possibilities along the Mediterranean Coast west of Alexandria and along the Red Sea south of Suez. There did not appear to be inland areas of high promise. It was decided that in Phase II, several continuous wind recording instruments would be established on the North Coast and Red Sea Coasts. Locations finally selected for the North Coast (South Coast of the Mediterranean) were distributed from Mersa Matruh to Borg El Arab, a coastal community about seventy kilometers west of Alexandria. The recorded data from the monitoring stations are presented.

  6. Small Business Innovation Research, Post-Phase II Opportunity Assessment

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.

    2015-01-01

    This report outlines current Small Business Innovation Research (SBIR) Post-Phase II opportunity contract award results for the SBIR technology program from 2007 to 2011 for NASA's Aeronautics Research Mission Directorate (ARMD), Human Exploration and Operations Mission Directorate (HEOMD), Science Mission Directorate (SMD), and Space Technology Mission Directorate (STMD). The report provides guidelines for incorporating SBIR technology into NASA programs and projects and provides a quantitative overview of the post-Phase II award patterns that correspond with each mission directorate at NASA Glenn Research Center (GRC). In recent years, one of NASA's goals has been to not only transfer SBIR technologies to commercial industries, but to ensure that NASA mission directorates incorporate SBIR technologies into their program and project activities. Before incorporating technologies into MD programs, it is important to understand each mission directorate structure because each directorate has different objectives and needs. The directorate program structures follow.

  7. Urban Integrated Industrial Cogeneration Systems Analysis. Phase II final report

    Energy Technology Data Exchange (ETDEWEB)

    1984-01-01

    Through the Urban Integrated Industrial Cogeneration Systems Analysis (UIICSA), the City of Chicago embarked upon an ambitious effort to identify the measure the overall industrial cogeneration market in the city and to evaluate in detail the most promising market opportunities. This report discusses the background of the work completed during Phase II of the UIICSA and presents the results of economic feasibility studies conducted for three potential cogeneration sites in Chicago. Phase II focused on the feasibility of cogeneration at the three most promising sites: the Stockyards and Calumet industrial areas, and the Ford City commercial/industrial complex. Each feasibility case study considered the energy load requirements of the existing facilities at the site and the potential for attracting and serving new growth in the area. Alternative fuels and technologies, and ownership and financing options were also incorporated into the case studies. Finally, site specific considerations such as development incentives, zoning and building code restrictions and environmental requirements were investigated.

  8. An Acoustic Plate Mode Sensor for Biowarfare Toxins, Phase II

    Science.gov (United States)

    1997-10-01

    04401 REPORT DATE: October 1997 TYPE OF REPORT: Annual, Phase II PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland...conducting research using animals, the investigator(s) adhered to the "Guide for the Care and Use of Laboratory Animals," prepared by the Committee on...Still, PMS (1) exhibited better than 75% of the binding from (6). Meanwhile, carboxymethylcellulose (CMC), which should have dramatically increased

  9. Survey of biomass gasification. Volume II. Principles of gasification

    Energy Technology Data Exchange (ETDEWEB)

    Reed, T.B. (comp.)

    1979-07-01

    Biomass can be converted by gasification into a clean-burning gaseous fuel that can be used to retrofit existing gas/oil boilers, to power engines, to generate electricity, and as a base for synthesis of methanol, gasoline, ammonia, or methane. This survey describes biomass gasification, associated technologies, and issues in three volumes. Volume I contains the synopsis and executive summary, giving highlights of the findings of the other volumes. In Volume II the technical background necessary for understanding the science, engineering, and commercialization of biomass is presented. In Volume III the present status of gasification processes is described in detail, followed by chapters on economics, gas conditioning, fuel synthesis, the institutional role to be played by the federal government, and recommendations for future research and development.

  10. Mercury Oxidation via Catalytic Barrier Filters Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Wayne Seames; Michael Mann; Darrin Muggli; Jason Hrdlicka; Carol Horabik

    2007-09-30

    In 2004, the Department of Energy National Energy Technology Laboratory awarded the University of North Dakota a Phase II University Coal Research grant to explore the feasibility of using barrier filters coated with a catalyst to oxidize elemental mercury in coal combustion flue gas streams. Oxidized mercury is substantially easier to remove than elemental mercury. If successful, this technique has the potential to substantially reduce mercury control costs for those installations that already utilize baghouse barrier filters for particulate removal. Completed in 2004, Phase I of this project successfully met its objectives of screening and assessing the possible feasibility of using catalyst coated barrier filters for the oxidation of vapor phase elemental mercury in coal combustion generated flue gas streams. Completed in September 2007, Phase II of this project successfully met its three objectives. First, an effective coating method for a catalytic barrier filter was found. Second, the effects of a simulated flue gas on the catalysts in a bench-scale reactor were determined. Finally, the performance of the best catalyst was assessed using real flue gas generated by a 19 kW research combustor firing each of three separate coal types.

  11. The sloan digital sky Survey-II supernova survey: search algorithm and follow-up observations

    Energy Technology Data Exchange (ETDEWEB)

    Sako, Masao [Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104 (United States); Bassett, Bruce [Department of Mathematics and Applied Mathematics, University of Cape Town, Rondebosch 7701 (South Africa); Becker, Andrew; Hogan, Craig J. [Department of Astronomy, University of Washington, Box 351580, Seattle, WA 98195 (United States); Cinabro, David [Department of Physics, Wayne State University, Detroit, MI 48202 (United States); DeJongh, Fritz; Frieman, Joshua A.; Marriner, John; Miknaitis, Gajus [Center for Particle Astrophysics, Fermi National Accelerator Laboratory, P.O. Box 500, Batavia, IL 60510 (United States); Depoy, D. L.; Prieto, Jose Luis [Department of Astronomy, Ohio State University, 140 West 18th Avenue, Columbus, OH 43210-1173 (United States); Dilday, Ben; Kessler, Richard [Kavli Institute for Cosmological Physics, The University of Chicago, 5640 South Ellis Avenue Chicago, IL 60637 (United States); Doi, Mamoru [Institute of Astronomy, Graduate School of Science, University of Tokyo 2-21-1, Osawa, Mitaka, Tokyo 181-0015 (Japan); Garnavich, Peter M. [University of Notre Dame, 225 Nieuwland Science, Notre Dame, IN 46556-5670 (United States); Holtzman, Jon [Department of Astronomy, MSC 4500, New Mexico State University, P.O. Box 30001, Las Cruces, NM 88003 (United States); Jha, Saurabh [Kavli Institute for Particle Astrophysics and Cosmology, Stanford University, P.O. Box 20450, MS29, Stanford, CA 94309 (United States); Konishi, Kohki [Institute for Cosmic Ray Research, University of Tokyo, 5-1-5, Kashiwanoha, Kashiwa, Chiba, 277-8582 (Japan); Lampeitl, Hubert [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Nichol, Robert C. [Institute of Cosmology and Gravitation, Mercantile House, Hampshire Terrace, University of Portsmouth, Portsmouth PO1 2EG (United Kingdom); and others

    2008-01-01

    The Sloan Digital Sky Survey-II Supernova Survey has identified a large number of new transient sources in a 300 deg{sup 2} region along the celestial equator during its first two seasons of a three-season campaign. Multi-band (ugriz) light curves were measured for most of the sources, which include solar system objects, galactic variable stars, active galactic nuclei, supernovae (SNe), and other astronomical transients. The imaging survey is augmented by an extensive spectroscopic follow-up program to identify SNe, measure their redshifts, and study the physical conditions of the explosions and their environment through spectroscopic diagnostics. During the survey, light curves are rapidly evaluated to provide an initial photometric type of the SNe, and a selected sample of sources are targeted for spectroscopic observations. In the first two seasons, 476 sources were selected for spectroscopic observations, of which 403 were identified as SNe. For the type Ia SNe, the main driver for the survey, our photometric typing and targeting efficiency is 90%. Only 6% of the photometric SN Ia candidates were spectroscopically classified as non-SN Ia instead, and the remaining 4% resulted in low signal-to-noise, unclassified spectra. This paper describes the search algorithm and the software, and the real-time processing of the SDSS imaging data. We also present the details of the supernova candidate selection procedures and strategies for follow-up spectroscopic and imaging observations of the discovered sources.

  12. Preliminary Exploratory Study of Different Phase II Collimators

    CERN Document Server

    Lari, L; Bertarelli, A; Bracco, C; Brugger, M; Cerutti, F; Dallocchio, Alessandro; Doyle, E; Ferrari, A; Keller, L; Lundgren, S; Markiewicz, T; Mauri, M; Roesler, S; Sarchiapone, L; Smith, J; Vlachoudis, V

    2008-01-01

    The LHC collimation system is installed and commissioned in different phases, following the natural evolution of the LHC performance. To improve cleaning efficiency towards the end of the low beta squeeze at 7TeV, and in stable physics conditions, it is foreseen to complement the 30 highly robust Phase I secondary collimators with low impedance Phase II collimators. At this stage, their design is not yet finalized. Possible options include metallic collimators, graphite jaws with a movable metallic foil, or collimators with metallic rotating jaws. As part of the evaluation of the different designs, the FLUKA Monte Carlo code is extensively used for calculating energy deposition and studying material damage and activation. This report outlines the simulation approach and defines the critical quantities involved.

  13. 94 studies on dog population in makurdi, nigeria (ii): a survey of ...

    African Journals Online (AJOL)

    STUDIES ON DOG POPULATION IN MAKURDI, NIGERIA (II): A SURVEY OF ... several studies on the ectoparasites of dogs have shown that ..... Epidemiological survey of. JOURNAL OF ... endoparasites of dogs and cats with selamectin.

  14. Statistical design in phase II clinical trials and its application in breast cancer.

    Science.gov (United States)

    Perrone, Francesco; Di Maio, Massimo; De Maio, Ermelinda; Maione, Paolo; Ottaiano, Alessandro; Pensabene, Matilde; Di Lorenzo, Giuseppe; Lombardi, Alessandra Vernaglia; Signoriello, Giuseppe; Gallo, Ciro

    2003-05-01

    Several statistical designs for phase II studies have been proposed, but they are frequently misunderstood or not applied at all. In this review we describe the major characteristics of the available designs. To investigate the extent to which statistical designs were used in some recent phase II studies, and which designs were the most common, we did a survey of 145 trials involving treatment of breast cancer. Studies selected for the survey were published between 1995 and 1999 in one of seven specific oncology journals (all with impact factor consistently higher than 2). 94 of the studies (64.8%) did not have an identifiable statistical design. However, among the 51 studies with statistical design there was a notable heterogeneity in the type of design applied. We put together a list of factors associated with use of statistical design at univariate analysis. These factors included: referral to a previous phase I study, recent trial start date, private sponsorship, single-agent treatment, and multicentre organisation. Single-agent treatment (OR 2.35; 95% CI 1.01-5.51) and multicentre organisation (OR 3.24; 95% CI 1.47-7.15) were independently predictive of the presence of statistical design. Publication in journals with high impact factors and short intervals between the start of the study and publication were also correlated with statistical design.

  15. Solar heating and cooling of mobile homes, Phase II. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Jacobsen, A.A.

    1976-12-01

    The specific objectives of the Phase II program were: (1) through system testing, confirm the feasibility of a solar heated and cooled mobile home; (2) update system performance analysis and provide solar heating and cooling computer model verification; (3) evaluate the performance of both an absorption and a Rankine air conditioning system; (4) perform a consumer demand analysis through field survey to ascertain the acceptance of solar energy into the mobile home market; and (5) while at field locations to conduct the consumer demand analysis, gather test data from various U.S. climatic zones. Results are presented and discussed. (WHK)

  16. Synthesis and processing of intelligent cost-effective structures phase II (SPICES II): smart materials aircraft applications evaluation

    Science.gov (United States)

    Dunne, James P.; Jacobs, Steven W.; Baumann, Erwin W.

    1998-06-01

    The second phase of the synthesis and processing of intelligent cost effective structures (SPICES II) program sought to identify high payoff areas for both naval and aerospace military systems and to evaluate military systems and to evaluate the benefits of smart materials incorporation based on their ability to redefine the mission scenario of the candidate platforms in their respective theaters of operation. The SPICES II consortium, consisting of The Boeing Company, Electric Boat Corporation, United Technologies Research Center, and Pennsylvania State University, surveyed the state-of-the-art in smart structures and evaluated potential applications to military aircraft, marine and propulsion systems components and missions. Eleven baseline platforms comprising a wide variety of missions were chosen for evaluation. Each platform was examined in its field of operation for areas which can be improved using smart materials insertion. Over 250 smart materials applications were proposed to enhance the platforms. The applications were examined and, when possible, quantitatively analyzed for their effect on mission performance. The applications were then ranked for payoff, risk, and time frame for development and demonstration. Details of the efforts made in the SPICES II program pertaining to smart structure applications on military and transport aircraft will be presented. A brief discussion of the core technologies will be followed by presentation of the criteria used in ranking each application. Thereafter, a selection of the higher ranking proposed concepts are presented in detail.

  17. Physics Detector Simulation Facility Phase II system software description

    Energy Technology Data Exchange (ETDEWEB)

    Scipioni, B.; Allen, J.; Chang, C.; Huang, J.; Liu, J.; Mestad, S.; Pan, J.; Marquez, M.; Estep, P.

    1993-05-01

    This paper presents the Physics Detector Simulation Facility (PDSF) Phase II system software. A key element in the design of a distributed computing environment for the PDSF has been the separation and distribution of the major functions. The facility has been designed to support batch and interactive processing, and to incorporate the file and tape storage systems. By distributing these functions, it is often possible to provide higher throughput and resource availability. Similarly, the design is intended to exploit event-level parallelism in an open distributed environment.

  18. The Data Release of the Sloan Digital Sky Survey-II Supernova Survey

    CERN Document Server

    Sako, Masao; Becker, Andrew C; Brown, Peter J; Campbell, Heather; Cane, Rachel; Cinabro, David; D'Andrea, Chris B; Dawson, Kyle S; DeJongh, Fritz; Depoy, Darren L; Dilday, Ben; Doi, Mamoru; Filippenko, Alexei V; Fischer, John A; Foley, Ryan J; Frieman, Joshua A; Galbany, Lluis; Garnavich, Peter M; Goobar, Ariel; Gupta, Ravi R; Hill, Gary J; Hayden, Brian T; Hlozek, Renee; Holtzman, Jon A; Hopp, Ulrich; Jha, Saurabh W; Kessler, Richard; Kollatschny, Wolfram; Leloudas, Giorgos; Marriner, John; Marshall, Jennifer L; Miquel, Ramon; Morokuma, Tomoki; Mosher, Jennifer; Nichol, Robert C; Nordin, Jakob; Olmstead, Matthew D; Ostman, Linda; Prieto, Jose L; Richmond, Michael; Romani, Roger W; Sollerman, Jesper; Stritzinger, Max; Schneider, Donald P; Smith, Mathew; Wheeler, J Craig; Yasuda, Naoki; Zheng, Chen

    2014-01-01

    This paper describes the data release of the Sloan Digital Sky Survey-II (SDSS-II) Supernova Survey conducted between 2005 and 2007. Light curves, spectra, classifications, and ancillary data are presented for 10,258 variable and transient sources discovered through repeat ugriz imaging of SDSS Stripe 82, a 300 deg2 area along the celestial equator. This data release is comprised of all transient sources brighter than r~22.5 mag with no history of variability prior to 2004. Dedicated spectroscopic observations were performed on a subset of 889 transients, as well as spectra for thousands of transient host galaxies using the SDSS-III BOSS spectrographs. Photometric classifications are provided for the candidates with good multi-color light curves that were not observed spectroscopically. From these observations, 4607 transients are either spectroscopically confirmed, or likely to be, supernovae, making this the largest sample of supernova candidates ever compiled. We present a new method for SN host-galaxy ide...

  19. The Data Release of the Sloan Digital Sky Survey-II Supernova Survey

    Energy Technology Data Exchange (ETDEWEB)

    Sako, Masao; et al.

    2014-01-14

    This paper describes the data release of the Sloan Digital Sky Survey-II (SDSS-II) Supernova Survey conducted between 2005 and 2007. Light curves, spectra, classifications, and ancillary data are presented for 10,258 variable and transient sources discovered through repeat ugriz imaging of SDSS Stripe 82, a 300 deg2 area along the celestial equator. This data release is comprised of all transient sources brighter than r~22.5 mag with no history of variability prior to 2004. Dedicated spectroscopic observations were performed on a subset of 889 transients, as well as spectra for thousands of transient host galaxies using the SDSS-III BOSS spectrographs. Photometric classifications are provided for the candidates with good multi-color light curves that were not observed spectroscopically. From these observations, 4607 transients are either spectroscopically confirmed, or likely to be, supernovae, making this the largest sample of supernova candidates ever compiled. We present a new method for SN host-galaxy identification and derive host-galaxy properties including stellar masses, star-formation rates, and the average stellar population ages from our SDSS multi-band photometry. We derive SALT2 distance moduli for a total of 1443 SN Ia with spectroscopic redshifts as well as photometric redshifts for a further 677 purely-photometric SN Ia candidates. Using the spectroscopically confirmed subset of the three-year SDSS-II SN Ia sample and assuming a flat Lambda-CDM cosmology, we determine Omega_M = 0.315 +/- 0.093 (statistical error only) and detect a non-zero cosmological constant at 5.7 sigmas.

  20. Rheumatic disease in a Philippine village. II: a WHO-ILAR-APLAR COPCORD study, phases II and III.

    Science.gov (United States)

    Wigley, R; Manahan, L; Muirden, K D; Caragay, R; Pinfold, B; Couchman, K G; Valkenburg, H A

    1991-01-01

    Many difficulties were encountered in a population survey of rheumatic complaints in a remote village area in the Philippines affecting the reliability of estimates of population prevalence. In phase I, a simple questionnaire identified 269 adults out of 950 who had rheumatic symptoms. In Phase II, 234 or 87% of positive respondents were requestioned using a more detailed pro forma. There were 196 with peripheral joint pain, 67 with neck pain and 137 with back pain. One third attributed their symptoms to work and 127 subjects had to stop work because of their complaints. Disability, including an inability to carry loads, affected nearly 1.8% of the population. Questions designed to detect rheumatoid arthritis and gout were not satisfactorily answered. Of those with complaints, 82% indicated that they still required help for their symptoms. In phase III, 166 subjects were medically examined. Osteoarthritis of the knee was found in 25 and 17 had Heberden's nodes. There were 16 with epicondylitis; 16 had rotator cuff pain and 35 had levator scapulae insertion pain. Three of these and three others had neck or shoulder swellings related to carrying loads on poles. Definite rheumatoid arthritis was diagnosed in two subjects and gout in five. No case of ankylosing spondylitis was identified. Thus, rheumatic complaints were common in this rural community and were frequently severe enough to cause disability and loss of time from work. Health worker education is required on how to handle these problems.

  1. Polymorphisms of phase I and phase II enzymes and breast cancer risk

    Directory of Open Access Journals (Sweden)

    Christina eJustenhoven

    2012-11-01

    Full Text Available Breast cancer is a complex disease which is provoked by a multitude of exogenous and endogenous factors including genetic variations. Recent genome-wide association studies identified a set of more than 18 novel low penetrant susceptibility loci, however, a limitation of this powerful approach is the hampered analysis of polymorphisms in DNA sequences with a high degree of similarity to other genes or pseudo genes. Since this common feature affects the majority of the highly polymorphic genes encoding phase I and II enzyme the retrieval of specific genotype data requires adapted amplification methods. With regard to breast cancer these genes are of certain interest due to their involvement in the metabolism of carcinogens like exogenous genotoxic compounds or steroid hormones. The present review summarizes the observed effects of functional genetic variants of phase I and II enzymes in well designed case control studies to shed light on their contribution to breast cancer risk.

  2. National Geoscience Data Repository System, Phase II. Final report, January 30, 1995--January 28, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    The American Geological Institute (AGI) has completed Phase II of a project to establish a National Geoscience Data Repository System (NGDRS). The project`s primary objectives are to preserve geoscience data in jeopardy of being destroyed and to make that data available to those who have a need to use it in future investigations. These data are available for donation to the public as a result of the downsizing that has occurred in the major petroleum and mining companies in the United States for the past decade. In recent years, these companies have consolidated domestic operations, sold many of their domestic properties and relinquished many of their leases. The scientific data associated with those properties are no longer considered to be useful assets and are consequently in danger of being lost forever. The national repository project will make many of these data available to the geoscience community for the first time. To address this opportunity, AGI sought support from the Department of Energy (DOE) in 1994 to initiate the NGDRS Phase I feasibility study to determine the types and quantity of data that companies would be willing to donate. The petroleum and mining companies surveyed indicated that they were willing to donate approximately five million well logs, one hundred million miles of seismic reflection data, millions of linear feet of core and cuttings, and a variety of other types of scientific data. Based on the positive results of the Phase I study, AGI undertook Phase II of the program in 1995. Funded jointly by DOE and industry, Phase II encompasses the establishment of standards for indexing and cataloging of geoscience data and determination of the costs of transferring data from the private sector to public-sector data repositories. Pilot projects evaluated the feasibility of the project for transfer of different data types and creation of a Web-based metadata supercatalog and browser.

  3. Phase I/II adaptive design for drug combination oncology trials

    OpenAIRE

    Wages, Nolan A.; Conaway, Mark R.

    2014-01-01

    Existing statistical methodology on dose finding for combination chemotherapies has focused on toxicity considerations alone in finding a maximum tolerated dose combination to recommend for further testing of efficacy in a phase II setting. Recently, there has been increasing interest in integrating phase I and phase II trials in order to facilitate drug development. In this article, we propose a new adaptive phase I/II method for dual-agent combinations that takes into account both toxicity ...

  4. Implementation of neutron phase contrast imaging at FRM-II

    Energy Technology Data Exchange (ETDEWEB)

    Lorenz, Klaus

    2008-11-12

    At ANTARES, the beam line for neutron imaging at the Forschungsneutronenquelle Heinz Maier-Leibnitz (FRM-II) in Garching, the option to do phase contrast imaging besides conventional absorption based neutron imaging was implemented and successfully used for the non-destructive testing of various types of objects. The used propagation-based technique is based on the interference of neutron waves in the detector plane that were differently strong diffracted by the sample. A comparison with other phase-sensitive neutron imaging techniques highlights assets and drawbacks of the different methods. In preliminary measurements at ANTARES and the spallation source SINQ at PSI in Villigen, the influence of the beam geometry, the neutron spectrum and the detector on the quality of the phase contrast measurements were investigated systematically. It was demonstrated that gamma radiation and epithermal neutrons in the beam contribute severely to background noise in measurements, which motivated the installation of a remotely controlled filter wheel for a quick and precise positioning of different crystal filters in the beam. By the installation of a similar aperture wheel, a quick change between eight different beam geometries was made possible. Besides pinhole and slit apertures, coded apertures based on non redundant arrays were investigated. The possibilities, which arise by the exploitation of the real part of the refractive index in neutron imaging, were demonstrated in experiments with especially designed test samples and in measurements with ordinary, industrial components. (orig.)

  5. Advanced Simulation Capability for Environmental Management (ASCEM) Phase II Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Freshley, M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hubbard, S. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Flach, G. [Savannah River National Lab. (SRNL), Aiken, SC (United States); Freedman, V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Agarwal, D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Andre, B. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bott, Y. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Chen, X. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Davis, J. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Faybishenko, B. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Gorton, I. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Murray, C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Moulton, D. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Meyer, J. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Rockhold, M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Shoshani, A. [LBNL; Steefel, C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Wainwright, H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Waichler, S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2012-09-28

    quality assurance. The Platform and HPC capabilities are being tested and evaluated for EM applications through a suite of demonstrations being conducted by the Site Applications Thrust. In 2010, the Phase I Demonstration focused on testing initial ASCEM capabilities. The Phase II Demonstration, completed in September 2012, focused on showcasing integrated ASCEM capabilities. For Phase II, the Hanford Site Deep Vadose Zone (BC Cribs) served as an application site for an end-to-end demonstration of ASCEM capabilities on a site with relatively sparse data, with emphasis on integration and linkages between the Platform and HPC components. Other demonstrations included in this Phase II report included addressing attenuation-based remedies at the Savannah River Site F-Area, to exercise linked ASCEM components under data-dense and complex geochemical conditions, and conducting detailed simulations of a representative waste tank. This report includes descriptive examples developed by the Hanford Site Deep Vadose Zone, the SRS F-Area Attenuation-Based Remedies for the Subsurface, and the Waste Tank Performance Assessment working groups. The integrated Phase II Demonstration provides test cases to accompany distribution of the initial user release (Version 1.0) of the ASCEM software tools to a limited set of users in 2013. These test cases will be expanded with each new release, leading up to the release of a version that is qualified for regulatory applications in the 2015 time frame.

  6. PHASE II VAULT TESTING OF THE ARGONNE RFID SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Willoner, T.; Turlington, R.; Koenig, R.

    2012-06-25

    The U.S. Department of Energy (DOE) (Environmental Management [EM], Office of Packaging and Transportation [EM-45]) Packaging and Certification Program (DOE PCP) has developed a Radio Frequency Identification (RFID) tracking and monitoring system, called ARG-US, for the management of nuclear materials packages during transportation and storage. The performance of the ARG-US RFID equipment and system has been fully tested in two demonstration projects in April 2008 and August 2009. With the strong support of DOE-SR and DOE PCP, a field testing program was completed in Savannah River Site's K-Area Material Storage (KAMS) Facility, an active Category I Plutonium Storage Facility, in 2010. As the next step (Phase II) of continued vault testing for the ARG-US system, the Savannah River Site K Area Material Storage facility has placed the ARG-US RFIDs into the 910B storage vault for operational testing. This latest version (Mark III) of the Argonne RFID system now has the capability to measure radiation dose and dose rate. This paper will report field testing progress of the ARG-US RFID equipment in KAMS, the operability and reliability trend results associated with the applications of the system, and discuss the potential benefits in enhancing safety, security and materials accountability. The purpose of this Phase II K Area test is to verify the accuracy of the radiation monitoring and proper functionality of the ARG-US RFID equipment and system under a realistic environment in the KAMS facility. Deploying the ARG-US RFID system leads to a reduced need for manned surveillance and increased inventory periods by providing real-time access to status and event history traceability, including environmental condition monitoring and radiation monitoring. The successful completion of the testing program will provide field data to support a future development and testing. This will increase Operation efficiency and cost effectiveness for vault operation. As the next step

  7. Inability of positive phase II clinical trials of investigational treatments to subsequently predict positive phase III clinical trials in glioblastoma.

    Science.gov (United States)

    Mandel, Jacob J; Yust-Katz, Shlomit; Patel, Akash J; Cachia, David; Liu, Diane; Park, Minjeong; Yuan, Ying; A Kent, Thomas; de Groot, John F

    2017-07-31

    Glioblastoma is the most common primary malignant brain tumor in adults, but effective therapies are lacking. With the scarcity of positive phase III trials, which are increasing in cost, we examined the ability of positive phase II trials to predict statistically significant improvement in clinical outcomes of phase III trials. A PubMed search was conducted to identify phase III clinical trials performed in the past 25 years for patients with newly diagnosed or recurrent glioblastoma. Trials were excluded if they did not examine an investigational chemotherapy or agent, if they were stopped early owing to toxicity, if they lacked prior phase II studies, or if a prior phase II study was negative. Seven phase III clinical trials in newly diagnosed glioblastoma and 4 phase III clinical trials in recurrent glioblastoma met the inclusion criteria. Only 1 (9%) phase III study documented an improvement in overall survival and changed the standard of care. The high failure rate of phase III trials demonstrates the urgent need to increase the reliability of phase II trials of treatments for glioblastoma. Strategies such as the use of adaptive trial designs, Bayesian statistics, biomarkers, volumetric imaging, and mathematical modeling warrant testing. Additionally, it is critical to increase our expectations of phase II trials so that positive findings increase the probability that a phase III trial will be successful.

  8. THE CARNEGIE-IRVINE GALAXY SURVEY. II. ISOPHOTAL ANALYSIS

    Energy Technology Data Exchange (ETDEWEB)

    Li Zhaoyu [Department of Astronomy, School of Physics, Peking University, Beijing 100871 (China); Ho, Luis C. [The Observatories of the Carnegie Institution for Science, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Barth, Aaron J. [Department of Physics and Astronomy, 4129 Frederick Reines Hall, University of California, Irvine, CA 92697-4575 (United States); Peng, Chien Y. [NRC Herzberg Institute of Astrophysics, 5071 West Saanich Road, Victoria, BC V9E 2E7 (Canada)

    2011-12-01

    The Carnegie-Irvine Galaxy Survey (CGS) is a comprehensive investigation of the physical properties of a complete, representative sample of 605 bright (B{sub T} {<=} 12.9 mag) galaxies in the southern hemisphere. This contribution describes the isophotal analysis of the broadband (BVRI) optical imaging component of the project. We pay close attention to sky subtraction, which is particularly challenging for some of the large galaxies in our sample. Extensive crosschecks with internal and external data confirm that our calibration and sky subtraction techniques are robust with respect to the quoted measurement uncertainties. We present a uniform catalog of one-dimensional radial profiles of surface brightness and geometric parameters, as well as integrated colors and color gradients. Composite profiles highlight the tremendous diversity of brightness distributions found in disk galaxies and their dependence on Hubble type. A significant fraction of S0 and spiral galaxies exhibit non-exponential profiles in their outer regions. We perform Fourier decomposition of the isophotes to quantify non-axisymmetric deviations in the light distribution. We use the geometric parameters, in conjunction with the amplitude and phase of the m = 2 Fourier mode, to identify bars and quantify their size and strength. Spiral arm strengths are characterized using the m = 2 Fourier profiles and structure maps. Finally, we utilize the information encoded in the m = 1 Fourier profiles to measure disk lopsidedness. The databases assembled here and in Paper I lay the foundation for forthcoming scientific applications of CGS.

  9. Pipe Overpack Container Fire Testing: Phase I & II

    Energy Technology Data Exchange (ETDEWEB)

    Figueroa, Victor G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ammerman, Douglas J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lopez, Carlos [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gill, Walter [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-05-01

    The Pipe Overpack Container (POC) was developed at Rocky Flats to transport plutonium residues with higher levels of plutonium than standard transuranic (TRU) waste to the Waste Isolation Pilot Plant (WIPP) for disposal. In 1996 Sandia National Laboratories (SNL) conducted a series of tests to determine the degree of protection POCs provided during storage accident events. One of these tests exposed four of the POCs to a 30-minute engulfing pool fire, resulting in one of the 7A drum overpacks generating sufficient internal pressure to pop off its lid and expose the top of the pipe container (PC) to the fire environment. The initial contents of the POCs were inert materials, which would not generate large internal pressure within the PC if heated. However, POCs are now being used to store combustible TRU waste at Department of Energy (DOE) sites. At the request of DOE’s Office of Environmental Management (EM) and National Nuclear Security Administration (NNSA), starting in 2015 SNL conducted a new series of fire tests to examine whether PCs with combustibles would reach a temperature that would result in (1) decomposition of inner contents and (2) subsequent generation of sufficient gas to cause the PC to over-pressurize and release its inner content. Tests conducted during 2015 and 2016, and described herein, were done in two phases. The goal of the first phase was to see if the PC would reach high enough temperatures to decompose typical combustible materials inside the PC. The goal of the second test phase was to determine under what heating loads (i.e., incident heat fluxes) the 7A drum lid pops off from the POC drum. This report will describe the various tests conducted in phase I and II, present preliminary results from these tests, and discuss implications for the POCs.

  10. Lunar Quest in Second Life, Lunar Exploration Island, Phase II

    Science.gov (United States)

    Ireton, F. M.; Day, B. H.; Mitchell, B.; Hsu, B. C.

    2010-12-01

    Linden Lab’s Second Life is a virtual 3D metaverse created by users. At any one time there may be 40,000-50,000 users on line. Users develop a persona and are seen on screen as a human figure or avatar. Avatars move through Second Life by walking, flying, or teleporting. Users form communities or groups of mutual interest such as music, computer graphics, and education. These groups communicate via e-mail, voice, and text within Second Life. Information on downloading the Second Life browser and joining can be found on the Second Life website: www.secondlife.com. This poster details Phase II in the development of Lunar Exploration Island (LEI) located in Second Life. Phase I LEI highlighted NASA’s LRO/LCROSS mission. Avatars enter LEI via teleportation arriving at a hall of flight housing interactive exhibits on the LRO/ LCROSS missions including full size models of the two spacecraft and launch vehicle. Storyboards with information about the missions interpret the exhibits while links to external websites provide further information on the mission, both spacecraft’s instrument suites, and related EPO. Other lunar related activities such as My Moon and NLSI EPO programs. A special exhibit was designed for International Observe the Moon Night activities with links to websites for further information. The sim includes several sites for meetings, a conference stage to host talks, and a screen for viewing NASATV coverage of mission and other televised events. In Phase II exhibits are updated to reflect on-going lunar exploration highlights, discoveries, and future missions. A new section of LEI has been developed to showcase NASA’s Lunar Quest program. A new exhibit hall with Lunar Quest information has been designed and is being populated with Lunar Quest information, spacecraft models (LADEE is in place) and kiosks. A two stage interactive demonstration illustrates lunar phases with static and 3-D stations. As NASA’s Lunar Quest program matures further

  11. MICS Asia Phase II - Sensitivity to the aerosol module

    CERN Document Server

    Sartelet, Karine; Sportisse, Bruno

    2007-01-01

    In the framework of the model inter-comparison study - Asia Phase II (MICS2), where eight models are compared over East Asia, this paper studies the influence of different parameterizations used in the aerosol module on the aerosol concentrations of sulfate and nitrate in PM10. An intracomparison of aerosol concentrations is done for March 2001 using different configurations of the aerosol module of one of the model used for the intercomparison. Single modifications of a reference setup for model configurations are performed and compared to a reference case. These modifications concern the size distribution, i.e. the number of sections, and physical processes, i.e. coagulation, condensation/evaporation, cloud chemistry, heterogeneous reactions and sea-salt emissions. Comparing monthly averaged concentrations at different stations, the importance of each parameterization is first assessed. It is found that sulfate concentrations are little sensitive to sea-salt emissions and to whether condensation is computed...

  12. Future physics potential of CMS Phase II detector

    CERN Document Server

    Pozzobon, Nicola

    2015-01-01

    To extend the LHC physics program, it is foreseen to operate the LHC in the future with an unprecedented high luminosity. To maintain the experiment’s physics potential in such harsh environment, the detector will need to be upgraded. At the same time the detector acceptance will be extended and new features such as a L1 track trigger will be implemented. Simulation studies evaluated the performance of the new, proposed detector components in comparison to the present detector with the expected aging after 1000 fb$^{-1}$. The impact of the expected Phase II performance on representative physics channels is studied. The sensitivity to find new physics beyond the SM is significantly improved and will allow to extend the SUSY reach, search for dark matter and exotic long-lived signatures. Precision Higgs and standard model measurements will gain substantially due to the improved performance.

  13. Small Business Innovation Research. Abstracts of Phase II awards, 2000

    Energy Technology Data Exchange (ETDEWEB)

    None

    2000-12-01

    The SBIR program enables DOE to obtain effective, innovative solutions to important problems through the private sector, which has a commercial incentive to pursue the resulting technology and bring it to the marketplace. The growing number of awardees, many of them started in business in response to SBIR solicitations, is becoming a significant resource for the solution of high risk, high technology problems for the Department. As detailed below, this publication describes the technical efforts and commercialization possibilities for SBIR Phase II awards in Fiscal Year (FY) 2000. It is intended for the educated layman, and maybe of particular interest to potential investors who wish to get in on the ground floor of exciting opportunities.

  14. The NEA Forum on Stakeholder Confidence - Phase I Lessons and Phase II Activities

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Peter [Natural Resources Canada, Ottawa (Canada). Uranium and Radioactive Waste Div.; Pescatore, Claudio [Nuclear Energy Agency, Paris (France)

    2006-09-15

    The Forum on Stakeholder Confidence (FSC) was created under a mandate from the OECD Nuclear Energy Agency (NEA) Radioactive Waste Management Committee (RWMC) to facilitate the sharing of international experience in addressing the societal dimension of radioactive waste management. It explores means of ensuring an effective dialogue with the public, and considers ways to strengthen confidence in decision-making processes. The Forum was launched in August 2000 and completed its first phase in 00 . Major findings and principles for action were published under the title of 'Learning and Adapting to Societal Requirements'. Activities of the FSC were also reported at Valdor 2003. In the second mandate of the FSC, there is continued use of a variety of tools and formats to allow dialogue among stakeholders in an atmosphere of mutual trust: national workshops and community visits, topical sessions, and desk and interview studies. In Phase II, the FSC is exploring: the link between research, development and demonstration and stakeholder confidence; cultural and organisational changes in RWM institutions; the role of media relations and outreach opportunities; tools and processes to help society prepare and manage decisions through stakeholder involvement; and increasing the value of waste management facilities to local communities. Workshops have been held in Germany and Spain. A large set of publications makes both Phase I and Phase II findings widely available.

  15. Phase I Report, US DOE GRED II Program

    Energy Technology Data Exchange (ETDEWEB)

    Fairbank Engineering Ltd.

    2003-04-23

    Noramex Corporation Inc, a Nevada company, owns a 100% interest in geothermal leases at the Blue Mountain Geothermal Area, Humboldt County, Nevada. The company is exploring the site for a geothermal resource suitable for development for electric power generation or In the spring of 2002, Noramex drilled the first geothermal observation hole at Blue Mountain, under a cost-share program with the U.S Department of Energy (DOE), under the DOE's Geothermal Exploration and Resource Definition (GRED) program, (Cooperative Agreement No. DE-FC04-00AL66972). DEEP BLUE No.1 was drilled to a total depth of 672.1 meters (2205 feet) and recorded a maximum temperature of 144.7 C (292.5 F). Noramex Corporation will now drill a second slim geothermal observation test hole at Blue Mountain, designated DEEP BLUE No.2. The hole will be drilled under a cost-share program with the DOE, under the DOE's Geothermal Exploration and Resource Definition II (GRED II) program, (Cooperative Agreement No. DE-FC04-2002AL68297). This report comprises Phase I of Cooperative Agreement No. DE-FC04-2002AL68297 of the GRED II program. The report provides an update on the status of resource confirmation at the Blue Mountain Geothermal Area, incorporating the results from DEEP BLUE No.1, and provides the technical background for a second test hole. The report also outlines the proposed drilling program for slim geothermal observation test hole DEEP BLUE No.2.

  16. The Development of New Measures of Cognitive Variables in Elementary School Children (Phase II). Final Report.

    Science.gov (United States)

    Asher, J. William; And Others

    This report covers Phase II of a two-phase project concerned with the development of new measures of cognitive variables in elementary school children. The four tasks undertaken in Phase II were: (1) prepare, revise and describe instruments designed to measure the cognitive variables categorized as concept formation, language development, logical…

  17. Easier Phase IIs: Recent Improvements to the Gemini User Tools

    Science.gov (United States)

    Miller, Bryan; Nuñez, A.

    2013-01-01

    During 2011 and 2012 Gemini Observatory undertook a significant project to improve the software tools used by investigators to propose for and prepare observations. The main goal was to make the definition of observation details (the Phase II process) easier and faster. The main initiatives included rewriting the observing proposal tool (Phase I Tool) and making several major improvements to the Observing Tool, including automatic settings for arc and flat exposures, automatic guide star selection for all instruments and wavefront sensors, and more complete initial template observations with capabilities for simultaneous editing of many observations. This poster explains these major changes as well as outlines future development plans. The Gemini Observatory is operated by the Association of Universities for Research in Astronomy, Inc., under a cooperative agreement with the NSF on behalf of the Gemini partnership: the National Science Foundation (United States), the Science and Technology Facilities Council (United Kingdom), the National Research Council (Canada), CONICYT (Chile), the Australian Research Council (Australia), Ministério da Ciência, Tecnologia e Inovação (Brazil), and Ministerio de Ciencia, Tecnología e Innovación Productiva (Argentina).

  18. Rooftop PV system. Final technical progress report, Phase II

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-08-01

    Under this four-year PV:BONUS Program, ECD and United Solar are developing and demonstrating two new lightweight flexible building integrated Photovoltaic (BIPV) modules specifically designed as exact replacements for conventional asphalt shingles and standing seam metal roofing. These modules can be economically and aesthetically integrated into new residential and commercial buildings, and address the even larger roofing replacement market. The modules are designed to be installed by roofing contractors without special training which minimizes the installation and balance of system costs. The modules will be fabricated from high-efficiency, multiple-junction a-Si alloy solar cells developed by ECD and United Solar. Under the Phase I Program, which ended in March 1994, we developed two different concept designs for rooftop PV modules: (1) the United Solar overlapping (asphalt shingle replacement) shingle-type modules and (2) the ECD metal roof-type modules. We also developed a plan for fabricating, testing and demonstrating these modules. Candidate demonstration sites for our rooftop PV modules were identified and preliminary engineering designs for these demonstrations were developed; a marketing study plan was also developed. The major objectives of the Phase II Program, which started in June 1994 was (1) to develop, test, and qualify these new rooftop modules; (2) to develop mechanical and electrical engineering specifications for the demonstration projects; and (3) to develop a marketing/commercialization plan.

  19. ALTERNATE REDUCTANT COLD CAP EVALUATION FURNACE PHASE II TESTING

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, F.; Stone, M.; Miller, D.

    2014-09-03

    Savannah River Remediation (SRR) conducted a Systems Engineering Evaluation (SEE) to determine the optimum alternate reductant flowsheet for the Defense Waste Processing Facility (DWPF). Specifically, two proposed flowsheets (nitric–formic–glycolic and nitric–formic–sugar) were evaluated based upon results from preliminary testing. Comparison of the two flowsheets among evaluation criteria indicated a preference towards the nitric–formic–glycolic flowsheet. Further research and development of this flowsheet eliminated the formic acid, and as a result, the nitric–glycolic flowsheet was recommended for further testing. Based on the development of a roadmap for the nitric–glycolic acid flowsheet, Waste Solidification Engineering (WS-E) issued a Technical Task Request (TTR) to address flammability issues that may impact the implementation of this flowsheet. Melter testing was requested in order to define the DWPF flammability envelope for the nitric-glycolic acid flowsheet. The Savannah River National Laboratory (SRNL) Cold Cap Evaluation Furnace (CEF), a 1/12th scale DWPF melter, was selected by the SRR Alternate Reductant project team as the melter platform for this testing. The overall scope was divided into the following sub-tasks as discussed in the Task Technical and Quality Assurance Plan (TTQAP):  Phase I - A nitric–formic acid flowsheet melter test (unbubbled) to baseline the CEF cold cap and vapor space data to the benchmark melter flammability models;  Phase II - A nitric–glycolic acid flowsheet melter test (unbubbled and bubbled) to: o Define new cold cap reactions and global kinetic parameters in support of the melter flammability model development; o Quantify off-gas surging potential of the feed; o Characterize off-gas condensate for complete organic and inorganic carbon species. After charging the CEF with cullet from Phase I CEF testing, the melter was slurry-fed with glycolic flowsheet based SB6-Frit 418 melter feed at 36

  20. Alternate Reductant Cold Cap Evaluation Furnace Phase II Testing

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, F. C. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Stone, M. E. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Miller, D. H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2014-09-03

    Savannah River Remediation (SRR) conducted a Systems Engineering Evaluation (SEE) to determine the optimum alternate reductant flowsheet for the Defense Waste Processing Facility (DWPF). Specifically, two proposed flowsheets (nitric–formic–glycolic and nitric–formic–sugar) were evaluated based upon results from preliminary testing. Comparison of the two flowsheets among evaluation criteria indicated a preference towards the nitric–formic–glycolic flowsheet. Further research and development of this flowsheet eliminated the formic acid, and as a result, the nitric–glycolic flowsheet was recommended for further testing. Based on the development of a roadmap for the nitric–glycolic acid flowsheet, Waste Solidification Engineering (WS-E) issued a Technical Task Request (TTR) to address flammability issues that may impact the implementation of this flowsheet. Melter testing was requested in order to define the DWPF flammability envelope for the nitric-glycolic acid flowsheet. The Savannah River National Laboratory (SRNL) Cold Cap Evaluation Furnace (CEF), a 1/12th scale DWPF melter, was selected by the SRR Alternate Reductant project team as the melter platform for this testing. The overall scope was divided into the following sub-tasks as discussed in the Task Technical and Quality Assurance Plan (TTQAP): Phase I - A nitric–formic acid flowsheet melter test (unbubbled) to baseline the CEF cold cap and vapor space data to the benchmark melter flammability models; Phase II - A nitric–glycolic acid flowsheet melter test (unbubbled and bubbled) to: Define new cold cap reactions and global kinetic parameters in support of the melter flammability model development; Quantify off-gas surging potential of the feed; Characterize off-gas condensate for complete organic and inorganic carbon species. After charging the CEF with cullet from Phase I CEF testing, the melter was slurry-fed with glycolic flowsheet based SB6-Frit 418 melter feed at 36% waste

  1. MHD seed recovery and regeneration, Phase II. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1994-10-01

    This final report summarizes the work performed by the Space and Technology Division of the TRW Space and Electronics Group for the U.S. Department of Energy, Pittsburgh Energy Technology Center for the Econoseed process. This process involves the economical recovery and regeneration of potassium seed used in the MHD channel. The contract period of performance extended from 1987 through 1994 and was divided into two phases. The Phase II test results are the subject of this Final Report. However, the Phase I test results are presented in summary form in Section 2.3 of this Final Report. The Econoseed process involves the treatment of the potassium sulfate in spent MHD seed with an aqueous calcium formate solution in a continuously stirred reactor system to solubilize, as potassium formate, the potassium content of the seed and to precipitate and recover the sulfate as calcium sulfate. The slurry product from this reaction is centrifuged to separate the calcium sulfate and insoluble seed constituents from the potassium formate solution. The dilute solids-free potassium formate solution is then concentrated in an evaporator. The concentrated potassium formate product is a liquid which can be recycled as a spray into the MHD channel. Calcium formate is the seed regenerant used in the Econoseed process. Since calcium formate is produced in the United States in relatively small quantities, a new route to the continuous production of large quantities of calcium formate needed to support an MHD power industry was investigated. This route involves the reaction of carbon monoxide gas with lime solids in an aqueous medium.

  2. Phase II Audit Report - Energy & Water Audits of LLNL Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Horst, B I; Jacobs, P C; Pierce, S M

    2005-08-03

    This report describes Phase II of a project conducted for the Mechanical Utilities Division (UTel), Energy Management Program at Lawrence Livermore National Laboratory (LLNL) by Architectural Energy Corporation (AEC). The overall project covers energy efficiency and water conservation auditing services for 215 modular and prefabricated buildings at LLNL. The primary goal of this project is to demonstrate compliance with DOE Order 430.2A, Contractor Requirements Document section 2.d (2) Document, to demonstrate annual progress of at least 10 percent toward completing energy and water audits of all facilities. Although this project covers numerous buildings, they are all similar in design and use. The approach employed for completing audits for these facilities involves a ''model-similar building'' approach. In the model-similar building approach, similarities between groups of buildings are established and quantified. A model (or test case) building is selected and analyzed for each model-similar group using a detailed DOE-2 simulation. The results are extended to the group of similar buildings based on careful application of quantified similarities, or ''extension measures''. This approach leverages the relatively minor effort required to evaluate one building in some detail to a much larger population of similar buildings. The facility wide energy savings potential was calculated for a select set of measures that have reasonable payback based on the detailed building analysis and are otherwise desirable to the LLNL facilities staff. The selected measures are: (1) HVAC Tune-up. This is considered to be a ''core measure'', based on the energy savings opportunity and the impact on thermal comfort. All HVAC units in the study are assumed to be tuned up under this measure. See the Appendix for a detailed calculation by building and HVAC unit. (2) HVAC system scheduling. This is also considered to be a &apos

  3. Investigational drugs in phase I and phase II clinical trials for thalassemia.

    Science.gov (United States)

    Motta, Irene; Scaramellini, Natalia; Cappellini, Maria Domenica

    2017-07-01

    Regular transfusion and iron chelation are the current treatment of severe forms of thalassemia. As a consequence of this demanding supportive treatment, there are several unmet therapeutic needs. Due to a deeper understanding in the pathophysiology of thalassemia, new therapeutic strategies have been developed that are now in pre-clinical and clinical trials. Areas covered: Activin receptor ligand traps (luspatercept and sotatercept), drugs targeting ineffective erythropoiesis, showed encouraging results in Phase I and II clinical trials. A phase III clinical trial is currently ongoing. Ruxolitinib, a Jak2 inhibitor, has been tested to limit stress erythropoiesis in a phase II clinical trial. In addition, improvement in iron chelation has been developed. Moreover, several trials of gene therapy are currently active in different countries with different lentiviral vectors. Expert opinion: The most promising molecules are the activin receptor ligand traps. Together with gene therapy these could be an alternative to bone marrow transplant, aiming towards a curative strategy. The main limit to gene therapy seems to be the conditioning regimen, thus an in vivo gene therapy would be more suitable. At pre-clinical level gene editing is showing extremely encouraging results.

  4. The extended ROSAT-ESO Flux Limited X-ray Galaxy Cluster Survey (REFLEX II)\\\\ II. Construction and Properties of the Survey

    CERN Document Server

    Böhringer, Hans; Collins, Chris A; Guzzo, Luigi; Nowak, Nina; Bobrovskyi, Sergei

    2014-01-01

    Galaxy clusters provide unique laboratories to study astrophysical processes on large scales and are important probes for cosmology. X-ray observations are currently the best means of detecting and characterizing galaxy clusters. In this paper we describe the construction of the REFLEX II galaxy cluster survey based on the southern part of the ROSAT All-Sky Survey. REFLEX II extends the REFLEX I survey by a factor of about two down to a flux limit of $1.8 \\times 10^{-12}$ erg s$^{-1}$ cm$^{-2}$ (0.1 - 2.4 keV). We describe the determination of the X-ray parameters, the process of X-ray source identification, and the construction of the survey selection function. The REFLEX II cluster sample comprises currently 915 objects. A standard selection function is derived for a lower source count limit of 20 photons in addition to the flux limit. The median redshift of the sample is $z = 0.102$. Internal consistency checks and the comparison to several other galaxy cluster surveys imply that REFLEX II is better than 9...

  5. Phased Retrofits in Existing Homes in Florida Phase II: Shallow Plus Retrofits

    Energy Technology Data Exchange (ETDEWEB)

    Sutherland, K. [Building America Partnership for Improved Residential Construction, Cocoa, FL (United States); Parker, D. [Building America Partnership for Improved Residential Construction, Cocoa, FL (United States); Martin, E. [Building America Partnership for Improved Residential Construction, Cocoa, FL (United States); Chasar, D. [Building America Partnership for Improved Residential Construction, Cocoa, FL (United States); Amos, B. [Building America Partnership for Improved Residential Construction, Cocoa, FL (United States)

    2016-02-03

    The BAPIRC team and Florida Power and Light (FPL) electric utility pursued a pilot phased energy-efficiency retrofit program in Florida by creating detailed data on the energy and economic performance of two levels of retrofit - simple and deep. For this Phased Deep Retrofit (PDR) project, a total of 56 homes spread across the utility partner's territory in east central Florida, southeast Florida, and southwest Florida were instrumented between August 2012 and January 2013, and received simple pass-through retrofit measures during the period of March 2013 - June 2013. Ten of these homes received a deeper package of retrofits during August 2013 - December 2013. A full account of Phase I of this project, including detailed home details and characterization, is found in Parker et al, 2015 (currently in draft). Phase II of this project, which is the focus of this report, applied the following additional retrofit measures to select homes that received a shallow retrofit in Phase I: a) Supplemental mini-split heat pump (MSHP) (6 homes); b) Ducted and space coupled Heat Pump Water Heater (8 homes); c) Exterior insulation finish system (EIFS) (1 homes); d) Window retrofit (3 homes); e) Smart thermostat (21 homes: 19 NESTs; 2 Lyrics); f) Heat pump clothes dryer (8 homes); g) Variable speed pool pump (5 homes).

  6. Be Stars as Seen Through Telescopes in Survey Mode (II)

    CERN Document Server

    Rivinius, Th; Baade, D

    2016-01-01

    The first half of the review dedicated to survey works on Be stars (Baade, Martayan, and Rivinius, this vol.) put emphasis on what we can learn from surveys about Be stars as a part of an environment, such as Be stars in binaries, Be stars in different metalicities, or Be stars as part of a star forming and then co-evolving group. This second half will rather concentrate on the information that more focused surveys can give on a Be star, understood as an individual object, and in this way attempts to bridge the gap between highly detailed single star studies, and necessarily broad survey and catalog work.

  7. Mercury Phase II Study - Mercury Behavior in Salt Processing Flowsheet

    Energy Technology Data Exchange (ETDEWEB)

    Jain, V. [Savannah River Remediation, LLC., Aiken, SC (United States); Shah, H. [Savannah River Remediation, LLC., Aiken, SC (United States). Sludge and Salt Planning; Bannochie, C. J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Wilmarth, W. R. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-07-25

    Mercury (Hg) in the Savannah River Site Liquid Waste System (LWS) originated from decades of canyon processing where it was used as a catalyst for dissolving the aluminum cladding of reactor fuel. Approximately 60 metric tons of mercury is currently present throughout the LWS. Mercury has long been a consideration in the LWS, from both hazard and processing perspectives. In February 2015, a Mercury Program Team was established at the request of the Department of Energy to develop a comprehensive action plan for long-term management and removal of mercury. Evaluation was focused in two Phases. Phase I activities assessed the Liquid Waste inventory and chemical processing behavior using a system-by-system review methodology, and determined the speciation of the different mercury forms (Hg+, Hg++, elemental Hg, organomercury, and soluble versus insoluble mercury) within the LWS. Phase II activities are building on the Phase I activities, and results of the LWS flowsheet evaluations will be summarized in three reports: Mercury Behavior in the Salt Processing Flowsheet (i.e. this report); Mercury Behavior in the Defense Waste Processing Facility (DWPF) Flowsheet; and Mercury behavior in the Tank Farm Flowsheet (Evaporator Operations). The evaluation of the mercury behavior in the salt processing flowsheet indicates, inter alia, the following: (1) In the assembled Salt Batches 7, 8 and 9 in Tank 21, the total mercury is mostly soluble with methylmercury (MHg) contributing over 50% of the total mercury. Based on the analyses of samples from 2H Evaporator feed and drop tanks (Tanks 38/43), the source of MHg in Salt Batches 7, 8 and 9 can be attributed to the 2H evaporator concentrate used in assembling the salt batches. The 2H Evaporator is used to evaporate DWPF recycle water. (2) Comparison of data between Tank 21/49, Salt Solution Feed Tank (SSFT), Decontaminated Salt Solution Hold Tank (DSSHT), and Tank 50 samples suggests that the total mercury as well as speciated

  8. An Overview of 2014 SBIR Phase I and Phase II Materials Structures for Extreme Environments

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.; Morris, Jessica R.

    2015-01-01

    NASA's Small Business Innovation Research (SBIR) program focuses on technological innovation by investing in development of innovative concepts and technologies to help NASA mission directorates address critical research needs for Agency programs. This report highlights nine of the innovative SBIR 2014 Phase I and Phase II projects that emphasize one of NASA Glenn Research Center's six core competencies-Materials and Structures for Extreme Environments. The technologies cover a wide spectrum of applications such as high temperature environmental barrier coating systems, deployable space structures, solid oxide fuel cells, and self-lubricating hard coatings for extreme temperatures. Each featured technology describes an innovation, technical objective, and highlights NASA commercial and industrial applications. This report provides an opportunity for NASA engineers, researchers, and program managers to learn how NASA SBIR technologies could help their programs and projects, and lead to collaborations and partnerships between the small SBIR companies and NASA that would benefit both.

  9. The role of technology in reducing health care costs. Phase II and phase III.

    Energy Technology Data Exchange (ETDEWEB)

    Cilke, John F.; Parks, Raymond C.; Funkhouser, Donald Ray; Tebo, Michael A.; Murphy, Martin D.; Hightower, Marion Michael; Gallagher, Linda K.; Craft, Richard Layne, II; Garcia, Rudy John

    2004-04-01

    In Phase I of this project, reported in SAND97-1922, Sandia National Laboratories applied a systems approach to identifying innovative biomedical technologies with the potential to reduce U.S. health care delivery costs while maintaining care quality. The effort provided roadmaps for the development and integration of technology to meet perceived care delivery requirements and an economic analysis model for development of care pathway costs for two conditions: coronary artery disease (CAD) and benign prostatic hypertrophy (BPH). Phases II and III of this project, which are presented in this report, were directed at detailing the parameters of telemedicine that influence care delivery costs and quality. These results were used to identify and field test the communication, interoperability, and security capabilities needed for cost-effective, secure, and reliable health care via telemedicine.

  10. Burrell-Optical-Kepler Survey (BOKS) II: Early Variability Results

    Science.gov (United States)

    Howell, Steve B.; Feldmeier, J.; von Braun, K.; Everett, M.; Mihos, C.; Harding, P.; Knox, C.; Sherry, W.; Lee, T.; Ciardi, D.; Rudick, C.; Proctor, M.; van Belle, G.

    2006-12-01

    We present preliminary results for the photometric time-series data obtained with the BOKS survey (see BOKS I poster Feldmeier et al.). The BOKS survey covers about 1 square degree in the constellation of Cygnus. We obtained nearly 2000 SDSS r-band images spanning a total time period of 39 days. Each point source in our BOKS survey is also present in the single epoch, 7-color photometric survey catalogue being produced by the NASA Discovery program Kepler mission. Light curves of approximately 60,000 point sources, spanning r=14 to 20, are examined and discussed. We will present variability demographics for the BOKS survey including characterization of the light curves into variable classes based on type, color, amplitude, and any extra-solar planet transit candidates.

  11. Profit based phase II sample size determination when adaptation by design is adopted

    OpenAIRE

    Martini, D.

    2014-01-01

    Background. Adaptation by design consists in conservatively estimating the phase III sample size on the basis of phase II data, and can be applied in almost all therapeutic areas; it is based on the assumption that the effect size of the drug is the same in phase II and phase III trials, that is a very common scenario assumed in product development. Adaptation by design reduces the probability on underpowered experiments and can improve the overall success probability of phase II and III tria...

  12. Thymostimulin in advanced hepatocellular carcinoma: A phase II trial

    Directory of Open Access Journals (Sweden)

    Behl Susanne

    2008-03-01

    Full Text Available Abstract Background Thymostimulin is a thymic peptide fraction with immune-mediated cytotoxicity against hepatocellular carcinoma in vitro. In a phase II trial, we investigated safety and efficacy including selection criteria for best response in advanced or metastasised hepatocellular carcinoma. Methods 44 patients (84 % male, median age 69 years not suitable or refractory to conventional therapy received thymostimulin 75 mg subcutaneously five times per week for a median of 8.2 months until progression or complete response. 3/44 patients were secondarily accessible to local ablation or chemoembolisation. Primary endpoint was overall survival, secondary endpoint tumor response or progression-free survival. A multivariate Cox's regression model was used to identify variables affecting survival. Results Median survival was 11.5 months (95% CI 7.9–15.0 with a 1-, 2- and 3-year survival of 50%, 23% and 9%. In the univariate analysis, a low Child-Pugh-score (p = 0.01, a low score in the Okuda- and CLIP-classification (p Conclusion Outcome in our study rather depended on liver function and intrahepatic tumor growth (presence of liver cirrhosis and Okuda stage in addition to response to thymostimulin, while an invasive HCC phenotype had no influence in the multivariate analysis. Thymostimulin could therefore be considered a safe and promising candidate for palliative treatment in a selected target population with advanced hepatocellular carcinoma, in particular as component of a multimodal therapy concept. Trial registration Current Controlled Trials ISRCTN29319366.

  13. Micromegas R&D for ATLAS MUON PHASE II Upgrade

    CERN Document Server

    Farina, Edoardo Maria; The ATLAS collaboration

    2017-01-01

    In the framework of the ATLAS Phase II Upgrade, a proposal to extend the detector acceptance of the muon system to high η has been put forward (namely up to | η| ~ 4). Extension of the muon coverage has been demonstrated to enhance physics performance. The proposed location for the new detector is in between the end-cap calorimeter cryostat and the JD shielding; in this region there is no magnetic field applied, the aim of the new detector is therefore to only tag muons without performing any momentum measurement. The new η tagger should cope with extremely high particle rate, that has been calculated, by means of simulations, to be 9 MHz at R = 25 cm and 0.4 MHz at R = 60 cm for μ = 200, where μ stands for the number of pp collisions per bunch crossing. The required spatial resolution at the inner edge of the detector has been estimated in few hundreds micrometres. One of the most promising candidate technology for the new detector is the MicroMegaS one, which has already been adopted for the NSW upgrad...

  14. CHAOS II: Gas-Phase Abundances in NGC 5194

    CERN Document Server

    Croxall, Kevin V; Berg, Danielle; Skillman, Evan D; Moustakas, John

    2015-01-01

    We have observed NGC5194 (M51a) as part of the CHemical Abundances of Spirals (CHAOS) project. Using the Multi Object Double Spectrographs (MODS) on the Large Binocular Telescope (LBT) we are able to measure one or more of the temperature-sensitive auroral lines ([O III] 4363, [N II] 5755, [S III] 6312) and thus measure "direct" gas-phase abundances in 29 individual HII regions. [O III] 4363 is only detected in two HII regions both of which show indications of excitation by shocks. We compare our data to previous direct abundances measured in NGC5194 and find excellent agreement for all but one region (Delta[log(O/H)] ~ 0.04). We find no evidence of trends in Ar/O, Ne/O, or S/O within NGC5194 or compared to other galaxies. We find modest negative gradients in both O/H and N/O with very little scatter (sigma = -0.62) suggests secondary nitrogen production is responsible for a significantly larger fraction of nitrogen (e.g., factor of 8-10) relative to primary production mechanisms than predicted by theoretica...

  15. Part 3: Pharmacogenetic Variability in Phase II Anticancer Drug Metabolism

    Science.gov (United States)

    Deenen, Maarten J.; Cats, Annemieke; Beijnen, Jos H.

    2011-01-01

    Equivalent drug doses may lead to wide interpatient variability in drug response to anticancer therapy. Known determinants that may affect the pharmacological response to a drug are, among others, nongenetic factors, including age, gender, use of comedication, and liver and renal function. Nonetheless, these covariates do not explain all the observed interpatient variability. Differences in genetic constitution among patients have been identified to be important factors that contribute to differences in drug response. Because genetic polymorphism may affect the expression and activity of proteins encoded, it is a key covariate that is responsible for variability in drug metabolism, drug transport, and pharmacodynamic drug effects. We present a series of four reviews about pharmacogenetic variability. This third part in the series of reviews is focused on genetic variability in phase II drug-metabolizing enzymes (glutathione S-transferases, uridine diphosphoglucuronosyl transferases, methyltransferases, sulfotransferases, and N-acetyltransferases) and discusses the effects of genetic polymorphism within the genes encoding these enzymes on anticancer drug therapy outcome. Based on the literature reviewed, opportunities for patient-tailored anticancer therapy are proposed. PMID:21659608

  16. The Phase II ATLAS Pixel Upgrade: The Inner Tracker (ITk)

    CERN Document Server

    Flick, Tobias; The ATLAS collaboration

    2016-01-01

    The entire tracking system of the ATLAS experiment will be replaced during the LHC Phase II shutdown (foreseen to take place around 2025) by an all-silicon detector called the ITk (Inner Tracker). The pixel detector will comprise the five innermost layers, and will be instrumented with new sensor and readout electronics technologies to improve the tracking performance and cope with the HL-LHC environment, which will be severe in terms of occupancy and radiation. The total surface area of silicon in the new pixel system could measure up to 14 m^2, depending on the final layout choice, which is expected to take place in early 2017. Four layout options are being investigated at the moment, two with forward coverage to eta < 3.2 and two to eta < 4. For each coverage option, a layout with long barrel staves and a layout with novel inclined support structures in the barrel-endcap overlap region are considered. All potential layouts include modules mounted on ring-shaped supports in the endcap regions. Support...

  17. Characterization of ToxCast Phase II compounds disruption of ...

    Science.gov (United States)

    The development of multi-well microelectrode array (mwMEA) systems has increased in vitro screening throughput making them an effective method to screen and prioritize large sets of compounds for potential neurotoxicity. In the present experiments, a multiplexed approach was used to determine compound effects on both neural function and cell health in primary cortical networks grown on mwMEA plates following exposure to ~1100 compounds from EPA’s Phase II ToxCast libraries. On DIV 13, baseline activity (40 min) was recorded prior to exposure to each compound at 40 µM. DMSO and the GABAA antagonist bicuculline (BIC) were included as controls on each mwMEA plate. Changes in spontaneous network activity (mean firing rate; MFR) and cell viability (lactate dehydrogenase; LDH and CellTiter Blue; CTB) were assessed within the same well following compound exposure. Activity calls (“hits”) were established using the 90th and 20th percentiles of the compound-induced change in MFR (medians of triplicates) across all tested compounds; compounds above (top 10% of compounds increasing MFR), and below (bottom 20% of compounds decreasing MFR) these thresholds, respectively were considered hits. MFR was altered beyond one of these thresholds by 322 compounds. Four compound categories accounted for 66% of the hits, including: insecticides (e.g. abamectin, lindane, prallethrin), pharmaceuticals (e.g. haloperidol, reserpine), fungicides (e.g. hexaconazole, fenamidone), and h

  18. First-year Sloan Digital Sky Survey-II (SDSS-II) Supernova Results: Hubble Diagram and Cosmological Parameters

    CERN Document Server

    Kessler, Richard; Cinabro, David; Vanderplas, Jake; Frieman, Joshua A; Marriner, John; Davis, Tamara M; Dilday, Benjamin; Holtzman, Jon; Jha, Saurabh; Lampeitl, Hubert; Sako, Masao; Smith, Mathew; Zheng, Chen; Nichol, Robert C; Bassett, Bruce; Bender, Ralf; Depoy, Darren L; Doi, Mamoru; Elson, Ed; Filippenko, Alex V; Foley, Ryan J; Garnavich, Peter M; Hopp, Ulrich; Ihara, Yutaka; Ketzeback, William; Kollatschny, W; Konishi, Kohki; Marshall, Jennifer L; McMillan, Russet J; Miknaitis, Gajus; Morokuma, Tomoki; M"ortsell, Edvard; Pan, Kaike; Prieto, Jose Luis; Richmond, Michael W; Riess, Adam G; Romani, Roger; Schneider, Donald P; Sollerman, Jesper; Takanashi, Naohiro; Tokita, Kouichi; van der Heyden, Kurt; Wheeler, J C; Yasuda, Naoki; York, Donald

    2009-01-01

    We present measurements of the Hubble diagram for 103 Type Ia supernovae (SNe) with redshifts 0.04 < z < 0.42, discovered during the first season (Fall 2005) of the Sloan Digital Sky Survey-II (SDSS-II) Supernova Survey. These data fill in the redshift "desert" between low- and high-redshift SN Ia surveys. We combine the SDSS-II measurements with new distance estimates for published SN data from the ESSENCE survey, the Supernova Legacy Survey, the Hubble Space Telescope, and a compilation of nearby SN Ia measurements. Combining the SN Hubble diagram with measurements of Baryon Acoustic Oscillations from the SDSS Luminous Red Galaxy sample and with CMB temperature anisotropy measurements from WMAP, we estimate the cosmological parameters w and Omega_M, assuming a spatially flat cosmological model (FwCDM) with constant dark energy equation of state parameter, w. For the FwCDM model and the combined sample of 288 SNe Ia, we find w = -0.76 +- 0.07(stat) +- 0.11(syst), Omega_M = 0.306 +- 0.019(stat) +- 0.023...

  19. National Youth Survey US: Wave II (NYS-1977)

    Data.gov (United States)

    U.S. Department of Health & Human Services — Youth data for the second wave of the National Youth Survey are contained in this data collection. The first wave was conducted in 1976. Youths were interviewed in...

  20. A Survey of Fertilizer Dealers: II. Sources of Agronomic Information.

    Science.gov (United States)

    Schmitt, M. A.

    1988-01-01

    Reports on a survey of fertilizer dealers that was conducted to assess how the dealers were obtaining their agronomic information, aside from formal training sessions, and determine if these sources of information were satisfactory in fulfilling the dealers' needs. (TW)

  1. Type II-P Supernovae from the SDSS-II Supernova Survey and the Standardized Candle Method

    CERN Document Server

    D'Andrea, Chris B; Dilday, Benjamin; Frieman, Joshua A; Holtzman, Jon; Kessler, Richard; Konishi, Kohki; Schneider, Donald P; Sollerman, Jesper; Wheeler, J C; Yasuda, Naoki; Cinabro, David; Jha, Saurabh; Nichol, Robert C; Lampeitl, Hubert; Smith, Mathew; Atlee, David W; Basset, Bruce; Castander, Francisco J; Goobar, Ariel; Miquel, Ramon; Nordin, Jakob; Östman, Linda; Prieto, Jose Luis; Quimby, Robert; Riess, Adam G; Stritzinger, Maximilian

    2009-01-01

    We apply the Standardized Candle Method (SCM) for Type II Plateau supernovae (SNe II-P), which relates the velocity of the ejecta of a SN to its luminosity during the plateau, to 15 SNe II-P discovered over the three season run of the Sloan Digital Sky Survey - II Supernova Survey. The redshifts of these SNe - 0.027 0.01) as all of the current literature on the SCM combined. We find that the SDSS SNe have a very small intrinsic I-band dispersion (0.22 mag), which can be attributed to selection effects. When the SCM is applied to the combined SDSS-plus-literature set of SNe II-P, the dispersion increases to 0.29 mag, larger than the scatter for either set of SNe separately. We show that the standardization cannot be further improved by eliminating SNe with positive plateau decline rates, as proposed in Poznanski et al. (2009). We thoroughly examine all potential systematic effects and conclude that for the SCM to be useful for cosmology, the methods currently used to determine the Fe II velocity at day 50 mus...

  2. Evaluation of hydrothermal resources of North Dakota. Phase II. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Harris, K.L.; Howell, F.L.; Winczewski, L.M.; Wartman, B.L.; Umphrey, H.R.; Anderson, S.B.

    1981-06-01

    The Phase II activities dealt with three main topical areas: geothermal gradient and heat-flow studies, stratigraphic studies, and water quality studies. Efforts were concentrated on Mesozoic and Cenozoic rocks. The geothermal gradient and heat-flow studies involved running temperature logs in groundwater observation holes in areas of interest, and locating, obtaining access to, and casing holes of convenience to be used as heat-flow determination sites. The stratigraphic and water quality studies involved two main efforts: updating and expanding WELLFILE and assembling a computer library system (WELLCAT) for all water wells drilled in the state. WATERCAT combines data from the United States Geological Survey Water Resources Division's WATSTOR and GWST computer libraries; and includes physical, stratigraphic, and water quality data. Goals, methods, and results are presented.

  3. A steerable/distance enhanced penetrometer delivery system: Phase II. Topical report

    Energy Technology Data Exchange (ETDEWEB)

    Amini, A.; Shenhar, J.; Lum, K.D.

    1996-05-01

    This report summarizes the phase II work on the Position Location Device (POLO) for penetrometers. Phase II was carried out to generate an integrated design of a full-scale steerable/distance enhanced penetrometer delivery system. Steering provides for the controlled and directional use of the penetrometer, while vibratory thrusting can provide greater penetration ability.

  4. TNX GeoSiphon Cell (TGSC-1) Phase II Single Cell Deployment/Demonstration Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Phifer, M.A.

    1999-04-15

    This Phase II final report documents the Phase II testing conducted from June 18, 1998 through November 13, 1998, and it focuses on the application of the siphon technology as a sub-component of the overall GeoSiphon Cell technology. [Q-TPL-T-00004

  5. Impact of Phase II cardiac rehabilitation on abnormal heart rate recovery

    Directory of Open Access Journals (Sweden)

    Chen-Liang Chou

    2014-09-01

    Conclusion: There are multiple factors of cardiopulmonary exercise tests that cannot be used to predict the effect of Phase II CR on the improvement of abnormal HRR. Forty-one percent of patients with abnormal HRR could improve after Phase II CR, but all of the patients could have improved exercise capacity regardless of whether or not HRR improved. We can conclude that HRR and exercise capacity change independently. However, it is important to closely follow-up during Phase III CR for patients with persistently abnormal HRR after Phase II CR has been completed.

  6. A Herschel [C ii] Galactic plane survey. I. The global distribution of ISM gas components

    Science.gov (United States)

    Pineda, J. L.; Langer, W. D.; Velusamy, T.; Goldsmith, P. F.

    2013-06-01

    Context. The [C ii] 158 μm line is an important tool for understanding the life cycle of interstellar matter. Ionized carbon is present in a variety of phases of the interstellar medium (ISM), including the diffuse ionized medium, warm and cold atomic clouds, clouds in transition from atomic to molecular, and dense and warm photon dominated regions. Aims: Velocity-resolved observations of [C ii] are the most powerful technique available to disentangle the emission produced by these components. These observations can also be used to trace CO-dark H2 gas and determine the total mass of the ISM. Methods: The Galactic Observations of Terahertz C+ (GOT C+) project surveys the [C ii] 158 μm line over the entire Galactic disk with velocity-resolved observations using the Herschel/HIFI instrument. We present the first longitude-velocity maps of the [C ii] emission for Galactic latitudes b = 0°, ±0.5°, and ±1.0°. We combine these maps with those of H i, 12CO, and 13CO to separate the different phases of the ISM and study their properties and distribution in the Galactic plane. Results: [C ii] emission is mostly associated with spiral arms, mainly emerging from Galactocentric distances between 4 and 10 kpc. It traces the envelopes of evolved clouds as well as clouds that are in the transition between atomic and molecular. We estimate that most of the observed [C ii] emission is produced by dense photon dominated regions (~47%), with smaller contributions from CO-dark H2 gas (~28%), cold atomic gas (~21%), and ionized gas (~4%). Atomic gas inside the Solar radius is mostly in the form of cold neutral medium (CNM), while the warm neutral medium gas dominates the outer galaxy. The average fraction of CNM relative to total atomic gas is ~43%. We find that the warm and diffuse CO-dark H2 is distributed over a larger range of Galactocentric distances (4-11 kpc) than the cold and dense H2 gas traced by 12CO and 13CO (4-8 kpc). The fraction of CO-dark H2 to total H2 increases

  7. Biomarkers in phase I–II chemoprevention trials: lessons from the NCI experience

    OpenAIRE

    Szabo, Eva

    2015-01-01

    Early phase clinical trials are an essential component of chemopreventive drug development to identify signals of drug efficacy that can subsequently be explored definitively in phase III trials. Whereas phase I trials focus on safety and identification of optimal dose and schedule for cancer prevention, phase II trials focus on intermediate endpoints that are variably related to cancer development. The United States National Cancer Institute supports a programme devoted to early phase cancer...

  8. Biomarker-Guided Adaptive Trial Designs in Phase II and Phase III: A Methodological Review.

    Directory of Open Access Journals (Sweden)

    Miranta Antoniou

    Full Text Available Personalized medicine is a growing area of research which aims to tailor the treatment given to a patient according to one or more personal characteristics. These characteristics can be demographic such as age or gender, or biological such as a genetic or other biomarker. Prior to utilizing a patient's biomarker information in clinical practice, robust testing in terms of analytical validity, clinical validity and clinical utility is necessary. A number of clinical trial designs have been proposed for testing a biomarker's clinical utility, including Phase II and Phase III clinical trials which aim to test the effectiveness of a biomarker-guided approach to treatment; these designs can be broadly classified into adaptive and non-adaptive. While adaptive designs allow planned modifications based on accumulating information during a trial, non-adaptive designs are typically simpler but less flexible.We have undertaken a comprehensive review of biomarker-guided adaptive trial designs proposed in the past decade. We have identified eight distinct biomarker-guided adaptive designs and nine variations from 107 studies. Substantial variability has been observed in terms of how trial designs are described and particularly in the terminology used by different authors. We have graphically displayed the current biomarker-guided adaptive trial designs and summarised the characteristics of each design.Our in-depth overview provides future researchers with clarity in definition, methodology and terminology for biomarker-guided adaptive trial designs.

  9. Microgrid Design, Development and Demonstration - Final Report for Phase I and Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Bose, Sumit; Krok, Michael

    2011-02-08

    This document constitutes GE’s final report for the Microgrid Design, Development and Demonstration program for DOE’s Office of Electricity Delivery and Energy Reliability, Award DE-FC02-05CH11349. It contains the final report for Phase I in Appendix I, and the results the work performed in Phase II. The program goal was to develop and demonstrate a Microgrid Energy Management (MEM) framework for a broad set of Microgrid applications that provides unified controls, protection, and energy management. This project contributed to the achievement of the U.S. Department of Energy’s Renewable and Distributed Systems Integration Program goals by developing a fully automated power delivery microgrid network that: - Reduces carbon emissions and emissions of other air pollutants through increased use of optimally dispatched renewable energy, - Increases asset use through integration of distributed systems, - Enhances reliability, security, and resiliency from microgrid applications in critical infrastructure protection, constrained areas of the electric grid, etc. - Improves system efficiency with on-site, distributed generation and improved economic efficiency through demand-side management.

  10. The Phase-II ATLAS ITk pixel upgrade

    Science.gov (United States)

    Terzo, S.

    2017-07-01

    The entire tracking system of the ATLAS experiment will be replaced during the LHC Phase-II shutdown (foreseen to take place around 2025) by an all-silicon detector called the ``ITk'' (Inner Tracker). The innermost portion of ITk will consist of a pixel detector with five layers in the barrel region and ring-shaped supports in the end-cap regions. It will be instrumented with new sensor and readout electronics technologies to improve the tracking performance and cope with the HL-LHC environment, which will be severe in terms of occupancy and radiation levels. The new pixel system could include up to 14 m2 of silicon, depending on the final layout, which is expected to be decided in 2017. Several layout options are being investigated at the moment, including some with novel inclined support structures in the barrel end-cap overlap region and others with very long innermost barrel layers. Forward coverage could be as high as |eta| carbon-based materials cooled by evaporative carbon dioxide circulated in thin-walled titanium pipes embedded in the structures. Planar, 3D, and CMOS sensors are being investigated to identify the optimal technology, which may be different for the various layers. The RD53 Collaboration is developing the new readout chip. The pixel off-detector readout electronics will be implemented in the framework of the general ATLAS trigger and DAQ system. A readout speed of up to 5 Gb/s per data link will be needed in the innermost layers going down to 640 Mb/s for the outermost. Because of the very high radiation level inside the detector, the first part of the transmission has to be implemented electrically, with signals converted for optical transmission at larger radii. Extensive tests are being carried out to prove the feasibility of implementing serial powering, which has been chosen as the baseline for the ITk pixel system due to the reduced material in the servicing cables foreseen for this option.

  11. Structural mechanisms of the Ih–II and II → Ic transitions between the crystalline phases of aqueous ice

    Energy Technology Data Exchange (ETDEWEB)

    Zheligovskaya, E. A., E-mail: lmm@phyche.ac.ru [Russian Academy of Sciences, Frumkin Institute of Physical Chemistry and Electrochemistry (Russian Federation)

    2015-09-15

    Structural mechanisms are proposed for experimentally observed phase transitions between crystalline modifications of aqueous ice, Ih and II, as well as II and Ic. It is known that the Ih–II transition occurs with the conservation of large structural units (hexagonal channels) common for these ices. It is shown that the Ih → II transition may occur with the conservation of 5/6 of all hydrogen bonds in crystal, including all hydrogen bonds in the retained channels (3/4 of the total number of bonds in crystal) and 1/3 of the bonds between these channels (1/12 of the total number). The transformation of other hydrogen bonds between the retained channels leads to the occurrence of proton order in ice II. A structural mechanism is proposed to explain the transformation of single crystals of ice Ih either into single crystals of ice II or into crystalline twins of ice II with c axes rotated by 180° with respect to each other, which is often observed at the Ih → II transition. It is established that up to 7/12 of all hydrogen bonds are retained at the irreversible cooperative II → Ic transition.

  12. A Type II Supernova Hubble Diagram from the CSP-I, SDSS-II, and SNLS Surveys

    Science.gov (United States)

    de Jaeger, T.; González-Gaitán, S.; Hamuy, M.; Galbany, L.; Anderson, J. P.; Phillips, M. M.; Stritzinger, M. D.; Carlberg, R. G.; Sullivan, M.; Gutiérrez, C. P.; Hook, I. M.; Howell, D. Andrew; Hsiao, E. Y.; Kuncarayakti, H.; Ruhlmann-Kleider, V.; Folatelli, G.; Pritchet, C.; Basa, S.

    2017-02-01

    The coming era of large photometric wide-field surveys will increase the detection rate of supernovae by orders of magnitude. Such numbers will restrict spectroscopic follow-up in the vast majority of cases, and hence new methods based solely on photometric data must be developed. Here, we construct a complete Hubble diagram of Type II supernovae (SNe II) combining data from three different samples: the Carnegie Supernova Project-I, the Sloan Digital Sky Survey II SN, and the Supernova Legacy Survey. Applying the Photometric Color Method (PCM) to 73 SNe II with a redshift range of 0.01–0.5 and with no spectral information, we derive an intrinsic dispersion of 0.35 mag. A comparison with the Standard Candle Method (SCM) using 61 SNe II is also performed and an intrinsic dispersion in the Hubble diagram of 0.27 mag, i.e., 13% in distance uncertainties, is derived. Due to the lack of good statistics at higher redshifts for both methods, only weak constraints on the cosmological parameters are obtained. However, assuming a flat universe and using the PCM, we derive the universe’s matter density: {{{Ω }}}m={0.32}-0.21+0.30 providing a new independent evidence for dark energy at the level of two sigma. This paper includes data gathered with the 6.5 m Magellan Telescopes, with the du Pont and Swope telescopes located at Las Campanas Observatory, Chile; and the Gemini Observatory, Cerro Pachon, Chile (Gemini Program N-2005A-Q-11, GN-2005B-Q-7, GN-2006A-Q-7, GS-2005A-Q-11, GS-2005B-Q-6, and GS-2008B-Q-56). Based on observations collected at the European Organization for Astronomical Research in the Southern Hemisphere, Chile (ESO Programmes 076.A-0156,078.D-0048, 080.A-0516, and 082.A-0526).

  13. Solid-phase extraction of Mn(II), Co(II), Ni(II), Cu(II), Cd(II) and Pb(II) ions from environmental samples by flame atomic absorption spectrometry (FAAS)

    Energy Technology Data Exchange (ETDEWEB)

    Duran, Celal [Department of Chemistry, Faculty of Art and Science, Karadeniz Technical University, 61080 Trabzon (Turkey); Gundogdu, Ali [Department of Chemistry, Faculty of Art and Science, Karadeniz Technical University, 61080 Trabzon (Turkey); Bulut, Volkan Numan [Department of Chemistry, Giresun Faculty of Art and Science, Karadeniz Technical University, 28049 Giresun (Turkey); Soylak, Mustafa [Department of Chemistry, Faculty of Art and Science, Erciyes University, 38039 Kayseri (Turkey)]. E-mail: soylak@erciyes.edu.tr; Elci, Latif [Department of Chemistry, Faculty of Art and Science, Pamukkale University, 20020 Denizli (Turkey); Sentuerk, Hasan Basri [Department of Chemistry, Faculty of Art and Science, Karadeniz Technical University, 61080 Trabzon (Turkey); Tuefekci, Mehmet [Department of Chemistry, Faculty of Art and Science, Karadeniz Technical University, 61080 Trabzon (Turkey)

    2007-07-19

    A new method using a column packed with Amberlite XAD-2010 resin as a solid-phase extractant has been developed for the multi-element preconcentration of Mn(II), Co(II), Ni(II), Cu(II), Cd(II), and Pb(II) ions based on their complex formation with the sodium diethyldithiocarbamate (Na-DDTC) prior to flame atomic absorption spectrometric (FAAS) determinations. Metal complexes sorbed on the resin were eluted by 1 mol L{sup -1} HNO{sub 3} in acetone. Effects of the analytical conditions over the preconcentration yields of the metal ions, such as pH, quantity of Na-DDTC, eluent type, sample volume and flow rate, foreign ions etc. have been investigated. The limits of detection (LOD) of the analytes were found in the range 0.08-0.26 {mu}g L{sup -1}. The method was validated by analyzing three certified reference materials. The method has been applied for the determination of trace elements in some environmental samples.

  14. Chitosan film loaded with silver nanoparticles-sorbent for solid phase extraction of Al(III), Cd(II), Cu(II), Co(II), Fe(III), Ni(II), Pb(II) and Zn(II).

    Science.gov (United States)

    Djerahov, Lubomir; Vasileva, Penka; Karadjova, Irina; Kurakalva, Rama Mohan; Aradhi, Keshav Krishna

    2016-08-20

    The present study describes the ecofriendly method for the preparation of chitosan film loaded with silver nanoparticles (CS-AgNPs) and application of this film as efficient sorbent for separation and enrichment of Al(III), Cd(II), Cu(II), Co(II), Fe(III), Ni(II), Pb(II) and Zn(II). The stable CS-AgNPs colloid was prepared by dispersing the AgNPs sol in chitosan solution at appropriate ratio and further used to obtain a cast film with very good stability under storage and good mechanical strength for easy handling in aqueous medium. The incorporation of AgNPs in the structure of CS film and interaction between the polymer matrix and nanoparticles were confirmed by UV-vis and FTIR spectroscopy. The homogeneously embedded AgNPs (average diameter 29nm, TEM analysis) were clearly observed throughout the film by SEM. The CS-AgNPs nanocomposite film shows high sorption activity toward trace metals under optimized chemical conditions. The results suggest that the CS-AgNPs nanocomposite film can be feasibly used as a novel sorbent material for solid-phase extraction of metal pollutants from surface waters.

  15. A comprehensive survey of M(2)AX phase elastic properties.

    Science.gov (United States)

    Cover, M F; Warschkow, O; Bilek, M M M; McKenzie, D R

    2009-07-29

    M(2)AX phases are a family of nanolaminate, ternary alloys that are composed of slabs of transition metal carbide or nitride (M(2)X) separated by single atomic layers of a main group element. In this combination, they manifest many of the beneficial properties of both ceramic and metallic compounds, making them attractive for many technological applications. We report here the results of a large scale computational survey of the elastic properties of all 240 elemental combinations using first-principles density functional theory calculations. We found correlations revealing the governing role of the A element and its interaction with the M element on the c axis compressibility and shearability of the material. The role of the X element is relatively minor, with the strongest effect seen in the in-plane constants C(11) and C(12). We identify several elemental compositions with extremal properties such as W(2)SnC, which has by far the lowest value of C(44), suggesting potential applications as a high-temperature dry lubricant.

  16. PHAT Stellar Cluster Survey. II. Andromeda Project Cluster Catalog

    CERN Document Server

    Johnson, L Clifton; Dalcanton, Julianne J; Wallace, Matthew L; Simpson, Robert J; Lintott, Chris J; Kapadia, Amit; Skillman, Evan D; Caldwell, Nelson; Fouesneau, Morgan; Weisz, Daniel R; Williams, Benjamin F; Beerman, Lori C; Gouliermis, Dimitrios A; Sarajedini, Ata

    2015-01-01

    We construct a stellar cluster catalog for the Panchromatic Hubble Andromeda Treasury (PHAT) survey using image classifications collected from the Andromeda Project citizen science website. We identify 2,753 clusters and 2,270 background galaxies within ~0.5 deg$^2$ of PHAT imaging searched, or ~400 kpc$^2$ in deprojected area at the distance of the Andromeda galaxy (M31). These identifications result from 1.82 million classifications of ~20,000 individual images (totaling ~7 gigapixels) by tens of thousands of volunteers. We show that our crowd-sourced approach, which collects >80 classifications per image, provides a robust, repeatable method of cluster identification. The high spatial resolution Hubble Space Telescope images resolve individual stars in each cluster and are instrumental in the factor of ~6 increase in the number of clusters known within the survey footprint. We measure integrated photometry in six filter passbands, ranging from the near-UV to the near-IR. PHAT clusters span a range of ~8 ma...

  17. A tutorial survey of topics in wireless networking: Part II

    Indian Academy of Sciences (India)

    Anurag Kumar; D Manjunath

    2007-12-01

    This is the second part of the survey of recent and emerging topics in wireless networking. We provide an overview of the area of wireless networking as that of dealing with problems of resource allocation so that the various connections that utilise the network achieve their desired performance objectives. In Part I we provided a taxonomy of wireless networks as they have been deployed. We then provided a quick survey of the main issues in the wireless 'physical' layer. We then discussed some resource allocation formulations in CDMA (code division multiple access) cellular networks and OFDMA (orthogonal frequency division multiple access) networks. In this part we begin with a discussion of random access wireless networks. We first provide an overview of the evolution of random access networks from Aloha to the currently popular 802·11 (Wi-Fi) networks. We then analyse the performance of the 802·11 random access protocol. We briefly discuss the problem of optimal association of nodes to Wi-Fi access points. Next, we consider topics in ad hoc multihop wireless networks. We first discuss topology and cross layer control. For the latter, we describe the important maximum weight link scheduling algorithm. The connectivity and capacity of randomly deployed networks are then analysed. Finally, we provide an overview of the technical issues in the emerging area of wireless sensor networks.

  18. SKA Weak Lensing II: Simulated Performance and Survey Design Considerations

    CERN Document Server

    Bonaldi, Anna; Camera, Stefano; Brown, Michael L

    2016-01-01

    We construct a pipeline for simulating weak lensing cosmology surveys with the Square Kilometre Array (SKA), taking as inputs telescope sensitivity curves; correlated source flux, size and redshift distributions; a simple ionospheric model; source redshift and ellipticity measurement errors. We then use this simulation pipeline to optimise a 2-year weak lensing survey performed with the first deployment of the SKA (SKA1). Our assessments are based on the total signal-to-noise of the recovered shear power spectra, a metric that we find to correlate very well with a standard dark energy figure of merit. We first consider the choice of frequency band, trading off increases in number counts at lower frequencies against poorer resolution; our analysis strongly prefers the higher frequency Band 2 (950-1760 MHz) channel of the SKA-MID telescope to the lower frequency Band 1 (350-1050 MHz). Best results would be obtained by allowing the centre of Band 2 to shift towards lower frequency, around 1.1 GHz. We then move o...

  19. The WSRT Virgo Hi filament survey II; Cross Correlation Data

    CERN Document Server

    Popping, Attila

    2011-01-01

    The extended environment of galaxies contains a wealth of information about the formation and life cycle of galaxies which are regulated by accretion and feedback processes. Observations of neutral hydrogen are routinely used to image the high brightness disks of galaxies and to study their kinematics. Deeper observations will give more insight into the distribution of diffuse gas in the extended halo of the galaxies and the IGM, where numerical simulations predict a cosmic web of extended structures and gaseous filaments. To observe the extended environment of galaxies, column density sensitivities have to be achieved that probe the regime of Lyman limit systems. HI observations are typically limited to a brightness sensitivity of NHI~10^19 cm-2, but this must be improved upon by ~2 orders of magnitude. In this paper we present the interferometric data of the Westerbork Virgo HI Filament Survey (WVFS) - the total power product of this survey has been published in an earlier paper. By observing at extreme hou...

  20. The Arecibo Galaxy Environment Survey VI : The Virgo Cluster (II)

    CERN Document Server

    Taylor, R; Auld, R; Minchin, R F; Smith, R

    2012-01-01

    We present 21 cm observations of a 5 x degree region in the Virgo cluster, obtained as part of the Arecibo Galaxy Environment Survey. 13 cluster members are detected, together with 36 objects in the background. We compare and contrast the results from this area with a larger 10 x degree region. We combine the two data sets to produce an HI mass function, which shows a higher detection rate at low masses (but finds fewer massive galaxies) than less sensitive wider-area surveys, such as ALFALFA. We find that the HI-detected galaxies are distributed differently to the non-detections, both spatially and in velocity, providing further evidence that the cluster is still assembling. We use the Tully-Fisher relation to examine the possibility of morphological evolution. We find that highly deficient galaxies, as well as some early-type galaxies, have much lower velocity widths than the Tully-Fisher relation predicts, indicating gas loss via ram pressure stripping. We also find that HI detections without optical count...

  1. Gravitational lensing statistics with extragalactic surveys - II. Analysis of the Jodrell Bank-VLA Astrometric Survey

    NARCIS (Netherlands)

    Helbig, P; Marlow, D; Quast, R; Wilkinson, PN; Browne, IWA; Koopmans, LVE

    We present constraints on the cosmological constant lambda(0) from gravitational lensing statistics of the Jodrell Bank-VLA Astrometric Survey (JVAS). Although this is the largest gravitational lens survey which has been analysed, cosmological constraints are only comparable to those from optical

  2. The Core Collapse Supernova Rate from the SDSS-II Supernova Survey

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, Matt; Cinabro, David; Dilday, Ben; Galbany, Lluis; Gupta, Ravi R.; Kessler, R.; Marriner, John; Nichol, Robert C.; Richmond, Michael; Schneider, Donald P.; Sollerman, Jesper

    2014-08-26

    We use the Sloan Digital Sky Survey II Supernova Survey (SDSS-II SNS) data to measure the volumetric core collapse supernova (CCSN) rate in the redshift range (0.03 < z < 0.09). Using a sample of 89 CCSN, we find a volume-averaged rate of 1.06 ± 0.19 × 10(–)(4)((h/0.7)(3)/(yr Mpc(3))) at a mean redshift of 0.072 ± 0.009. We measure the CCSN luminosity function from the data and consider the implications on the star formation history.

  3. Bright but slow - Type II supernovae from OGLE-IV - Implications for magnitude limited surveys

    OpenAIRE

    Poznanski, Dovi; Kostrzewa-Rutkowska, Zuzanna; Wyrzykowski, Lukasz; Blagorodnova, Nadejda

    2015-01-01

    We study a sample of 11 Type II supernovae (SNe) discovered by the OGLE-IV survey. All objects have well sampled I-band light curves, and at least one spectrum. We find that 2 or 3 of the 11 SNe have a declining light curve, and spectra consistent with other SNe II-L, while the rest have plateaus that can be as short as 70d, unlike the 100d typically found in nearby galaxies. The OGLE SNe are also brighter, and show that magnitude limited surveys find SNe that are different than usually found...

  4. The core collapse supernova rate from the SDSS-II supernova survey

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, Matt; Cinabro, David [Department of Physics and Astronomy, Wayne State University, Detroit, MI 48202 (United States); Dilday, Ben [Spokane, WA 99203 (United States); Galbany, Lluis [Millennium Institute of Astrophysics, Universidad de Chile, Casilla 36-D, Santiago (Chile); Gupta, Ravi R. [Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104 (United States); Kessler, R. [Department of Astronomy and Astrophysics, University of Chicago, Chicago, IL 60637 (United States); Marriner, John [Center for Particle Astrophysics, Fermi National Accelerator Laboratory, P.O. Box 500, Batavia, IL 60510 (United States); Nichol, Robert C. [Institute of Cosmology and Gravitation, Dennis Sciama Building, University of Portsmouth, Portsmouth PO1 2FX (United Kingdom); Richmond, Michael [School of Physics and Astronomy, Rochester Institute of Technology, Rochester, NY 14623 (United States); Schneider, Donald P. [Department of Astronomy and Astrophysics, The Pennsylvania State University, University Park, PA 16802 (United States); Sollerman, Jesper, E-mail: cinabro@physics.wayne.edu [The Oskar Klein Centre, Department of Astronomy, AlbaNova, SE-106 91 Stockholm (Sweden)

    2014-09-10

    We use the Sloan Digital Sky Survey II Supernova Survey (SDSS-II SNS) data to measure the volumetric core collapse supernova (CCSN) rate in the redshift range (0.03 < z < 0.09). Using a sample of 89 CCSN, we find a volume-averaged rate of 1.06 ± 0.19 × 10{sup –4}((h/0.7){sup 3}/(yr Mpc{sup 3})) at a mean redshift of 0.072 ± 0.009. We measure the CCSN luminosity function from the data and consider the implications on the star formation history.

  5. Silicon Sensor Prototypes for the Phase II Upgrade of the CMS Tracker

    CERN Document Server

    Bergauer, Thomas

    2015-01-01

    The CMS Tracker will be completely exchanged in the so called Phase-II upgrade. To preserve and enhance its performance in the High-Luminosity LHC phase, the new tracker will need to cope with very high radiation levels, track densities and pile-ups. In addition, it needs to provide input for the level-1 trigger. In this paper we present the baseline design of the new tracker, with a special emphasis on the two detector module concepts for the outer tracker, the 2S and PS module. The CMS Tracker collaboration designed and procured sensor prototypes from several vendors. These productions are intended for evaluating the production quality of the manufacturers, for providing functional sensors for module prototypes and for concluding the survey towards a suitable silicon base material and sensor design. Here we provide first results of the PS-p macro-pixel-light sensor and of full-scale strip sensor prototypes for the 2S module concept, both on 6- and 8-inch wafers.

  6. HLW Salt Disposition Alternatives Preconceptual Phase II Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Piccolo, S.F.

    1999-07-09

    The purpose of the report is to summarize the process used to identify the Short List alternatives that will be evaluated during Phase III and to document the results of the selection process. The Phase III evaluation will result in the determination of the preferred alternative(s) to be used for final disposition of the HLW salt to a permitted waste form.

  7. Phenology for Resource Management and Decision Making: Phase I and II Program Evaluation and Final Report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes the work completed on Phase I and II of the Project from September 1, 2014 through February 14, 2017. Included are the Goals and Objectives...

  8. Trimodality therapy for malignant pleural mesothelioma: Results from an EORTC phase II multicentre trial

    NARCIS (Netherlands)

    P.E.Y. van Schil (Paul); P. Baas (Paul); R.M. Gaafar (Rabab); A.W.P.M. Maat (Alex); F. Van De Pol (Francien); B. Hasane (B.); H.M. Klomp (Houke); A.M. Abdelrahman (A.); J. Welche (J.); J.P. van Meerbeeck (Jan)

    2010-01-01

    textabstractThe European Organisation for Research and Treatment of Cancer (EORTC; protocol 08031) phase II trial investigated the feasibility of trimodality therapy consisting of induction chemotherapy followed by extrapleural pneumonectomy and post-operative radiotherapy in patients with malignant

  9. Functional design criteria for project W-252, phase II liquid effluent treatment and disposal. Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    Hatch, C.E.

    1995-05-01

    This document is the Functional Design Criteria for Project W-252. Project W-252 provides the scope to provide BAT/AKART (best available technology...) to 200 Liquid Effluent Phase II streams (B-Plant). This revision (Rev. 2) incorporates a major descoping of the project. The descoping was done to reflect a combination of budget cutting measures allowed by a less stringent regulatory posture toward the Phase II streams

  10. Seroepidemiologic studies in Oaxaca, Mexico. II. Survey for arbovirus antibody.

    Science.gov (United States)

    Goldsmith, R S; Zarate, M L; Cedeño-Ferreira, J; Antonio Paz, E

    1979-01-01

    A serologic survey was conducted in south-western Mexico to obtain information on human experience with arbovirus infections. Sera were collected from two semitropical areas along the Pacific coast of Oaxaca State, two mountain areas above 1,700 meters and the interior valley at 1,500 meters. Of the 610 sera tested for group A antibody, 4.9 per cent were positive in the hemagglutination-inhibition (HI) test to Venezuelan (VE), 11 per cent to Eastern, and none to Western encephalitis viruses. In neutralization tests the antibody was shown to be probably due to VE virus infections. When sera were screened for group B antibodies in the HI test, 32 per cent were positive with St. Louis encephalitis (SLE), 19 per cent with Ilhéus, and 4 per cent with yellow fever viruses. The pattern of reactions suggested that SLE or an antigenically related virus was responsible for the antibody detected. An unusually high rate was found in a mountain area at 2,000 meters: 41 per cent of 113 persons tested were seropositive to SLE. Of 493 sera screened by complement-fixation test, 6 per cent were positive to Nepuyo, 4 per cent to Patois, and 3 per cent to Tlacotalpan viruses.

  11. The Pittsburgh Sloan Digital Sky Survey MgII Quasar Absorption-Line Survey Catalog

    CERN Document Server

    Quider, Anna M; Turnshek, David A; Rao, Sandhya M; Monier, Eric M; Weyant, Anja N; Busche, Joseph R

    2011-01-01

    We present a catalog of intervening MgII quasar absorption-line systems in the redshift interval 0.36 17,000 measured MgII doublets. We also present data on the ~44,600 quasar spectra which were searched to construct the catalog, including redshift and magnitude information, continuum-normalized spectra, and corresponding arrays of redshift-dependent minimum rest equivalent widths detectable at our confidence threshold. The catalog is available on the web. A careful second search of 500 random spectra indicated that, for every 100 spectra searched, approximately one significant MgII system was accidentally rejected. Current plans to expand the catalog beyond DR4 quasars are discussed. Many MgII absorbers are known to be associated with galaxies. Therefore, the combination of large size and well understood statistics makes this catalog ideal for precision studies of the low-ionization and neutral gas regions associated with galaxies at low to moderate redshift. An analysis of the statistics of MgII absorbers ...

  12. River Protection Project Integrated safety management system phase II verification report, volumes I and II - 8/19/99

    Energy Technology Data Exchange (ETDEWEB)

    SHOOP, D.S.

    1999-09-10

    The Department of Energy policy (DOE P 450.4) is that safety is integrated into all aspects of the management and operations of its facilities. In simple and straightforward terms, the Department will ''Do work safely.'' The purpose of this River Protection Project (RPP) Integrated Safety Management System (ISMS) Phase II Verification was to determine whether ISMS programs and processes are implemented within RFP to accomplish the goal of ''Do work safely.'' The goal of an implemented ISMS is to have a single integrated system that includes Environment, Safety, and Health (ES&H) requirements in the work planning and execution processes to ensure the protection of the worker, public, environment, and federal property over the RPP life cycle. The ISMS is comprised of the (1) described functions, components, processes, and interfaces (system map or blueprint) and (2) personnel who are executing those assigned roles and responsibilities to manage and control the ISMS. Therefore, this review evaluated both the ''paper'' and ''people'' aspects of the ISMS to ensure that the system is implemented within RPP. Richland Operations Office (RL) conducted an ISMS Phase I Verification of the TWRS from September 28-October 9, 1998. The resulting verification report recommended that TWRS-RL and the contractor proceed with Phase II of ISMS verification given that the concerns identified from the Phase I verification review are incorporated into the Phase II implementation plan.

  13. 2009-2010 USACE Vicksburg District Lidar: Mississippi Phase II

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Phase two will consist of post processing of the data collected. Aeroquest Optimal, Inc. shall process the digital elevation data from a precision airborne (LIDAR)...

  14. Benzocaine polymorphism: pressure-temperature phase diagram involving forms II and III.

    Science.gov (United States)

    Gana, Inès; Barrio, Maria; Do, Bernard; Tamarit, Josep-Lluís; Céolin, René; Rietveld, Ivo B

    2013-11-18

    Understanding the phase behavior of an active pharmaceutical ingredient in a drug formulation is required to avoid the occurrence of sudden phase changes resulting in decrease of bioavailability in a marketed product. Benzocaine is known to possess three crystalline polymorphs, but their stability hierarchy has so far not been determined. A topological method and direct calorimetric measurements under pressure have been used to construct the topological pressure-temperature diagram of the phase relationships between the solid phases II and III, the liquid, and the vapor phase. In the process, the transition temperature between solid phases III and II and its enthalpy change have been determined. Solid phase II, which has the highest melting point, is the more stable phase under ambient conditions in this phase diagram. Surprisingly, solid phase I has not been observed during the study, even though the scarce literature data on its thermal behavior appear to indicate that it might be the most stable one of the three solid phases.

  15. Installation Restoration Program. Phase II. Confirmation/Quantification Stage I.

    Science.gov (United States)

    1986-02-24

    level below ground: vmA Temp. Addres Fahr . * Teat delivery.: pm _________________________________or -- - r Pump’ _7 Ral= _ Owner’s...esapletLea Or abadomat Of the 11." W= OWEI is oft drlled ole: - Tota2- Ii-e ,1 . p of well: at ag wter lev below O-0 Temp. Fahr . M eat er...Institute for Occupational Safety and Health (NIOSH). In addition, UBTL is currently licensed by the Center for Disease Control (CDC) to perform

  16. Bright but slow - Type II supernovae from OGLE-IV & magnitude limited surveys

    CERN Document Server

    Poznanski, Dovi; Wyrzykowski, Lukasz; Blagorodnova, Nadejda

    2015-01-01

    We study a sample of 11 Type II supernovae (SNe) discovered by the OGLE-IV survey. All objects have well sampled I-band light curves, and at least one spectrum. We find that 3 or 4 of the 11 SNe have a declining light curve, making them SNe II-L, while the rest have plateaus that can be as short as 70d, unlike the 100d typically found in nearby galaxies. These SNe are also brighter than found in the local Universe, and show that magnitude limited surveys find SNe that are different than found in nearby galaxies. We discuss this sample in the context of understanding Type II SNe as a class and their suggested use as standard candles.

  17. The Sloan Digital Sky Survey-II Supernova Survey:Search Algorithm and Follow-up Observations

    Energy Technology Data Exchange (ETDEWEB)

    Sako, Masao; /Pennsylvania U. /KIPAC, Menlo Park; Bassett, Bruce; /Cape Town U. /South African Astron. Observ.; Becker, Andrew; /Washington U., Seattle, Astron. Dept.; Cinabro, David; /Wayne State U.; DeJongh, Don Frederic; /Fermilab; Depoy, D.L.; /Ohio State U.; Doi, Mamoru; /Tokyo U.; Garnavich, Peter M.; /Notre Dame U.; Craig, Hogan, J.; /Washington U., Seattle, Astron. Dept.; Holtzman, Jon; /New Mexico State U.; Jha, Saurabh; /Stanford U., Phys. Dept.; Konishi, Kohki; /Tokyo U.; Lampeitl, Hubert; /Baltimore, Space; Marriner, John; /Fermilab; Miknaitis, Gajus; /Fermilab; Nichol, Robert C.; /Portsmouth U.; Prieto, Jose Luis; /Ohio State U.; Richmond, Michael W.; /Rochester Inst.; Schneider, Donald P.; /Penn State U., Astron. Astrophys.; Smith, Mathew; /Portsmouth U.; SubbaRao, Mark; /Chicago U. /Tokyo U. /Tokyo U. /South African Astron. Observ. /Tokyo

    2007-09-14

    The Sloan Digital Sky Survey-II Supernova Survey has identified a large number of new transient sources in a 300 deg2 region along the celestial equator during its first two seasons of a three-season campaign. Multi-band (ugriz) light curves were measured for most of the sources, which include solar system objects, Galactic variable stars, active galactic nuclei, supernovae (SNe), and other astronomical transients. The imaging survey is augmented by an extensive spectroscopic follow-up program to identify SNe, measure their redshifts, and study the physical conditions of the explosions and their environment through spectroscopic diagnostics. During the survey, light curves are rapidly evaluated to provide an initial photometric type of the SNe, and a selected sample of sources are targeted for spectroscopic observations. In the first two seasons, 476 sources were selected for spectroscopic observations, of which 403 were identified as SNe. For the Type Ia SNe, the main driver for the Survey, our photometric typing and targeting efficiency is 90%. Only 6% of the photometric SN Ia candidates were spectroscopically classified as non-SN Ia instead, and the remaining 4% resulted in low signal-to-noise, unclassified spectra. This paper describes the search algorithm and the software, and the real-time processing of the SDSS imaging data. We also present the details of the supernova candidate selection procedures and strategies for follow-up spectroscopic and imaging observations of the discovered sources.

  18. Grassmann phase space methods for fermions. II. Field theory

    Energy Technology Data Exchange (ETDEWEB)

    Dalton, B.J., E-mail: bdalton@swin.edu.au [Centre for Quantum and Optical Science, Swinburne University of Technology, Melbourne, Victoria 3122 (Australia); Jeffers, J. [Department of Physics, University of Strathclyde, Glasgow G4ONG (United Kingdom); Barnett, S.M. [School of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ (United Kingdom)

    2017-02-15

    In both quantum optics and cold atom physics, the behaviour of bosonic photons and atoms is often treated using phase space methods, where mode annihilation and creation operators are represented by c-number phase space variables, with the density operator equivalent to a distribution function of these variables. The anti-commutation rules for fermion annihilation, creation operators suggests the possibility of using anti-commuting Grassmann variables to represent these operators. However, in spite of the seminal work by Cahill and Glauber and a few applications, the use of Grassmann phase space methods in quantum-atom optics to treat fermionic systems is rather rare, though fermion coherent states using Grassmann variables are widely used in particle physics. This paper presents a phase space theory for fermion systems based on distribution functionals, which replace the density operator and involve Grassmann fields representing anti-commuting fermion field annihilation, creation operators. It is an extension of a previous phase space theory paper for fermions (Paper I) based on separate modes, in which the density operator is replaced by a distribution function depending on Grassmann phase space variables which represent the mode annihilation and creation operators. This further development of the theory is important for the situation when large numbers of fermions are involved, resulting in too many modes to treat separately. Here Grassmann fields, distribution functionals, functional Fokker–Planck equations and Ito stochastic field equations are involved. Typical applications to a trapped Fermi gas of interacting spin 1/2 fermionic atoms and to multi-component Fermi gases with non-zero range interactions are presented, showing that the Ito stochastic field equations are local in these cases. For the spin 1/2 case we also show how simple solutions can be obtained both for the untrapped case and for an optical lattice trapping potential.

  19. DEMONSTRATION OF FUEL CELLS TO RECOVER ENERGY FROM LANDFILL GAS: PHASE II. PRETREATMENT SYSTEM PERFORMANCE MEASUREMENT

    Science.gov (United States)

    The report describes Phase II of a demonstration of the utilization of commercial phosphoric acid fuel cells to recover energy from landfill gas. This phase consisted primarily of the construction and testing of a Gas Pretreatment Unit (GPU) whose function is to remove those impu...

  20. Phase I/II study on docetaxel, gemcitabine and prednisone in castrate refractory metastatic prostate cancer

    DEFF Research Database (Denmark)

    Buch-Hansen, Trine Zeeberg; Bentzen, Lise Nørgaard; Hansen, Steinbjoern

    2010-01-01

    PURPOSE: We assessed the efficacy and toxicity of a fixed dose of docetaxel and prednisone, combined with escalating doses of gemcitabine (DGP). The primary endpoint was PSA response. METHODS: Fifteen patients were enrolled in the phase I and 50 patients entered the phase II. Patients were given ...

  1. Phase I/II study on docetaxel, gemcitabine and prednisone in castrate refractory metastatic prostate cancer

    DEFF Research Database (Denmark)

    Buch-Hansen, Trine Zeeberg; Bentzen, Lise Nørgaard; Hansen, Steinbjoern;

    2010-01-01

    PURPOSE: We assessed the efficacy and toxicity of a fixed dose of docetaxel and prednisone, combined with escalating doses of gemcitabine (DGP). The primary endpoint was PSA response. METHODS: Fifteen patients were enrolled in the phase I and 50 patients entered the phase II. Patients were given...

  2. An Experimental Evaluation of Hyperactivity and Food Additives. 1977-Phase II.

    Science.gov (United States)

    Harley, J. Preston; And Others

    Phase II of a study on the effectiveness of B. Feingold's recommended diet for hyperactive children involved the nine children (mean age 9 years) who had shown the "best" response to diet manipulation in Phase I. Each child served as his own control and was challenged with specified amounts of placebo and artificial color containing food…

  3. Implementation of a Proficiency-Based Diploma System in Maine: Phase II--District Level Analysis

    Science.gov (United States)

    Silvernail, David L.; Stump, Erika K.; McCafferty, Anita Stewart; Hawes, Kathryn M.

    2014-01-01

    This report describes the findings from Phase II of a study of Maine's implementation of a proficiency-based diploma system. At the request of the Joint Standing Committee on Education and Cultural Affairs of the Maine Legislature, the Maine Policy Research Institute (MEPRI) has conducted a two-phased study of the implementation of Maine law…

  4. A Class I and Class II Methanol Maser Survey of Extended Green Objects (EGOs) from the GLIMPSE Survey

    CERN Document Server

    Cyganowski, C J; Hunter, T R; Churchwell, E

    2009-01-01

    We present the results of a high angular resolution Very Large Array (VLA) Class I 44 GHz and Class II 6.7 GHz methanol maser survey of a sample of ~20 massive young stellar object (MYSO) outflow candidates selected on the basis of extended 4.5 micron emission in Spitzer Galactic Legacy Infrared Mid-Plane Survey Extraordinaire (GLIMPSE) images. These 4.5 micron-selected candidates are referred to as extended green objects (EGOs), for the common coding of this band as green in three-color IRAC images. The detection rate of 6.7 GHz Class II methanol masers, which are associated exclusively with massive YSOs, towards EGOs is greater than ~64%--nearly double the detection rate of surveys using other MYSO selection criteria. The detection rate of Class I 44 GHz methanol masers, which trace molecular outflows, is ~89% towards EGOs associated with 6.7 GHz methanol masers. The two types of methanol masers exhibit different spatial distributions: 6.7 GHz masers are centrally concentrated and usually coincide with 24 m...

  5. Phase-II trials in osteosarcoma recurrences: A systematic review of past experience.

    Science.gov (United States)

    Omer, Natacha; Le Deley, Marie-Cécile; Piperno-Neumann, Sophie; Marec-Berard, Perrine; Italiano, Antoine; Corradini, Nadège; Bellera, Carine; Brugières, Laurence; Gaspar, Nathalie

    2017-04-01

    The most appropriate design of Phase-II trials evaluating new therapies in osteosarcoma remains poorly defined. To study consistency in phase-II clinical trials evaluating new therapies for osteosarcoma recurrences with respect to eligibility criteria, response assessment, end-points, statistical design and reported results. Systematic review of clinical trials registered on clinicaltrials.gov, clinicaltrialsregister.eu and French National Cancer Institute website or referenced in PubMed and American Society of Clinical Oncology websites, between 2003 and 2016, using the following criteria: (osteosarcoma OR bone sarcoma) AND (Phase-II). Among the 99 trials identified, 80 were Phase-II, 17 I/II and 2 II/III, evaluating mostly targeted therapy (n = 40), and chemotherapy alone (n = 26). Results were fully (n = 28) or partially (abstract, n = 6) published. Twenty-four trials were dedicated to osteosarcoma, 22 had an osteosarcoma stratum. Twenty-eight out of 99 trials refer to the age range observed at recurrence (28%). Overall, 65 trials were run in multicentre settings, including 17 international trials. Only 9 trials were randomised. The primary end-point was tumour response in 71 trials (response rate, n = 40 or best response, n = 31), with various definitions (complete + partial ± minor response and stable disease), mainly evaluated with RECIST criteria (n = 69); it was progression-free survival in 24 trials and OS in 3. In single-arm trials evaluating response rate, the null hypothesis tested (when available, n = 12) varied from 5% to 25%. No robust historical data can currently be derived from past efficacy Phase-II trials. There is an urgent need to develop international randomised Phase-II trials across all age ranges with standardised primary end-point. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Technical Analysis of the Hydrogen Energy Station Concept, Phase I and Phase II

    Energy Technology Data Exchange (ETDEWEB)

    TIAX, LLC

    2005-05-04

    patterns would be most viable for an energy station, TIAX developed several criteria for selecting a representative set of technology configurations. TIAX applied these criteria to all possible technology configurations to determine an optimized set for further analysis, as shown in Table ES-1. This analysis also considered potential energy station operational scenarios and their impact upon hydrogen and power production. For example, an energy station with a 50-kWe reformer could generate enough hydrogen to serve up to 12 vehicles/day (at 5 kg/fill) or generate up to 1,200 kWh/day, as shown in Figure ES-1. Buildings that would be well suited for an energy station would utilize both the thermal and electrical output of the station. Optimizing the generation and utilization of thermal energy, hydrogen, and electricity requires a detailed look at the energy transfer within the energy station and the transfer between the station and nearby facilities. TIAX selected the Baseline configuration given in Table ES-1 for an initial analysis of the energy and mass transfer expected from an operating energy station. Phase II The purpose of this technical analysis was to analyze the development of a hydrogen-dispensing infrastructure for transportation applications through the installation of a 50-75 kW stationary fuel cell-based energy station at federal building sites. The various scenarios, costs, designs and impacts of such a station were quantified for a hypothetical cost-shared program that utilizes a natural gas reformer to provide hydrogen fuel for both the stack(s) and a limited number of fuel cell powered vehicles, with the possibility of using cogeneration to support the building heat load.

  7. Research safety vehicle program (Phase II) specification review. Volume II. Final technical report, Jul 1975--Nov 1976

    Energy Technology Data Exchange (ETDEWEB)

    Pugliese, S.M.

    1977-02-01

    In Phase I of the Research Safety Vehicle Program (RSV), preliminary design and performance specifications were developed for a mid-1980's vehicle that integrates crashworthiness and occupant safety features with material resource conservation, economy, and producibility. Phase II of the program focused on development of the total vehicle design via systems engineering and integration analyses. As part of this effort, it was necessary to continuously review the Phase I recommended performance specification in relation to ongoing design/test activities. This document contains the results of analyses of the Phase I specifications. The RSV is expected to satisfy all of the producibility and safety related specifications, i.e., handling and stability systems, crashworthiness, occupant protection, pedestrian/cyclist protection, etc.

  8. The HIFI spectral survey of AFGL 2591 (CHESS). II. Summary of the survey

    CERN Document Server

    Kazmierczak-Barthel, M; Helmich, F P; Chavarria, L; Wang, K -S; Ceccarelli, C

    2014-01-01

    This paper presents the richness of submillimeter spectral features in the high-mass star forming region AFGL 2591. As part of the CHESS (Chemical Herschel Survey of Star Forming Regions) Key Programme, AFGL 2591 was observed by the Herschel/HIFI instrument. The spectral survey covered a frequency range from 480 up to 1240 GHz as well as single lines from 1267 to 1901 GHz (i.e. CO, HCl, NH3, OH and [CII]). Rotational and population diagram methods were used to calculate column densities, excitation temperatures and the emission extents of the observed molecules associated with AFGL 2591. The analysis was supplemented with several lines from ground-based JCMT spectra. From the HIFI spectral survey analysis a total of 32 species were identified (including isotopologues). In spite of the fact that lines are mostly quite week, 268 emission and 16 absorption lines were found (excluding blends). Molecular column densities range from 6e11 to 1e19 cm-2 and excitation temperatures range from 19 to 175 K. One can disti...

  9. Washington Phase II Fish Diversion Screen Evaluations in the Yakima River Basin, 2002 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Carter, J.; McMichael, G.; Chamness, M. (Pacific Northwest National Laboratory)

    2003-01-01

    In 2002, the Pacific Northwest National Laboratory evaluated 23 Phase II fish screen sites in the Yakima River Basin as part of a multi-year project for the Bonneville Power Administration on the effectiveness of fish screening devices. Pacific Northwest National Laboratory collected data to determine whether velocities in front of the screens and in the bypasses met National Marine Fisheries Service criteria to promote safe and timely fish passage and whether bypass outfall conditions allowed fish to safely return to the river. In addition, Pacific Northwest National Laboratory conducted underwater video surveys to evaluate the environmental and operational conditions of the screen sites with respect to fish passage. Based on evaluations in 2002, PNNL concluded that: (1) In general, water velocity conditions at the screen sites met fish passage criteria set by the National Marine Fisheries Service. (2) Conditions at most facilities would be expected to provide for safe juvenile fish passage. (3) Conditions at some facilities indicate that operation and/or maintenance should be modified to increase safe juvenile fish passage. (4) Automated cleaning brushes generally functioned properly; chains and other moving parts were typically well greased and operative. (5) Removal of sediment buildup and accumulated leafy and woody debris should be improved at some sites.

  10. Physical and Morphological Properties of [O II] Emitting Galaxies in the HETDEX Pilot Survey

    CERN Document Server

    Bridge, Joanna S; Ciardullo, Robin; Hagen, Alex; Zeimann, Greg; Malz, A I; Acquaviva, Viviana; Schneider, Donald P; Drory, Niv; Gebhardt, Karl; Jogee, Shardha

    2014-01-01

    The Hobby-Eberly Dark Energy Experiment pilot survey identified 284 [O II] 3727 emitting galaxies in a 169 square-arcminute field of sky in the redshift range 0 < z < 0.57. This line flux limited sample provides a bridge between studies in the local universe and higher-redshift [O II] surveys. We present an analysis of the star formation rates (SFRs) of these galaxies as a function of stellar mass as determined via spectral energy distribution fitting. The [O II] emitters fall on the "main sequence" of star-forming galaxies with SFR decreasing at lower masses and redshifts. However, the slope of our relation is flatter than that found for most other samples, a result of the metallicity dependence of the [O II] star formation rate indicator. The mass specific SFR is higher for lower mass objects, supporting the idea that massive galaxies formed more quickly and efficiently than their lower mass counterparts. This is confirmed by the fact that the equivalent widths of the [O II] emission lines trend small...

  11. Comparing two tetraalkylammonium ionic liquids. II. Phase transitions

    Science.gov (United States)

    Lima, Thamires A.; Paschoal, Vitor H.; Faria, Luiz F. O.; Ribeiro, Mauro C. C.; Ferreira, Fabio F.; Costa, Fanny N.; Giles, Carlos

    2016-06-01

    Phase transitions of the ionic liquids n-butyl-trimethylammonium bis(trifluoromethanesulfonyl)imide, [N1114][NTf2], and methyl-tributylammonium bis(trifluoromethanesulfonyl)imide, [N1444][NTf2], were investigated by differential scanning calorimetry (DSC), X-ray diffraction (XRD) measurements, and Raman spectroscopy. XRD and Raman spectra were obtained as a function of temperature at atmospheric pressure, and also under high pressure at room temperature using a diamond anvil cell (DAC). [N1444][NTf2] experiences glass transition at low temperature, whereas [N1114][NTf2] crystallizes or not depending on the cooling rate. Both the ionic liquids exhibit glass transition under high pressure. XRD and low-frequency Raman spectra provide a consistent physical picture of structural ordering-disordering accompanying the thermal events of crystallization, glass transition, cold crystallization, pre-melting, and melting. Raman spectra in the high-frequency range of some specific cation and anion normal modes reveal conformational changes of the molecular structures along phase transitions.

  12. Changes of Multiple Metal Accumulation (MMA in New Orleans Soil: Preliminary Evaluation of Differences between Survey I (1992 and Survey II (2000

    Directory of Open Access Journals (Sweden)

    Paul W. Mielke

    2005-08-01

    Full Text Available Soil metal surveys were conducted in Baltimore, MD (1976-1979, Minnesota (1981-1988 and most recently, New Orleans, LA (1989-present. The unique characteristic of New Orleans is that it has two surveys; Survey I was completed in 1992 and Survey II was completed in 2000. This paper seeks to determine if there is a perceptible change in the amount of metals during less than a decade that separated these surveys. The Survey I collection was 4,026 samples stratified by 283 census tracts. All samples were collected in residential neighborhoods at least one block from a busy street. The Survey II collection was 5,467 samples stratified by 286 census tracts (plus City Park. The Survey II collection included busy streets as a category of samples. For comparison, the busy street category of 1,078 samples was excluded from Survey II for a total of 4,388 samples. The extraction methods of the two surveys used the same protocol for strength of acid (1 M HNO3, shaker-time (2 hours, and room temperature (~22ºC. However, Survey II differed in amount of sample used in extraction. For Surveys I and II, 4.0g and 0.4g were used respectively. The same ICP-AES was used to measure 8 metals in both surveys. To evaluate the analytical results of the two methods, reference soil samples (n=36 from the Wageningen Evaluating Programs for Analytical Laboratories, International Soil-analytical Exchange (WEPAL; ISE were used. The relationship between the 4.0 and 0.4 g results were linear and the Survey I results were adjusted for sample:acid ratio. Further evaluation was done by creating interpolated Multiple Metal Accumulation (MMA maps based on the median MMA for each census tract. A new map was created by dividing Survey II MMA by Survey I MMA. The ratio indicates increases of soil metals in the inner city and decreases of soil metals in the outlying areas of Metropolitan New Orleans. Comparing fresh parent alluvium from the Mississippi River with urban soil metal

  13. Generation of phase II in vitro metabolites using homogenized horse liver.

    Science.gov (United States)

    Wong, Jenny K Y; Chan, George H M; Leung, David K K; Tang, Francis P W; Wan, Terence S M

    2016-02-01

    The successful use of homogenized horse liver for the generation of phase I in vitro metabolites has been previously reported by the authors' laboratory. Prior to the use of homogenized liver, the authors' laboratory had been using mainly horse liver microsomes for carrying out equine in vitro metabolism studies. Homogenized horse liver has shown significant advantages over liver microsomes for in vitro metabolism studies as the procedures are much quicker and have higher capability for generating more in vitro metabolites. In this study, the use of homogenized liver has been extended to the generation of phase II in vitro metabolites (glucuronide and/or sulfate conjugates) using 17β-estradiol, morphine, and boldenone undecylenate as model substrates. It was observed that phase II metabolites could also be generated even without the addition of cofactors. To the authors' knowledge, this is the first report of the successful use of homogenized horse liver for the generation of phase II metabolites. It also demonstrates the ease with which both phase I and phase II metabolites can now be generated in vitro simply by using homogenized liver without the need for ultracentrifuges or tedious preparation steps.

  14. A spatial assessment of ecosystem services in Europe - Phase II

    DEFF Research Database (Denmark)

    Maes, Joachim; Hauck, Jennifer; Paracchini,, Maria Luisa

    Mainstreaming ecosystem services in EU decision making processes requires a solid conceptual and methodological framework for mapping and assessing ecosystem services that serve the multiple objectives addressed by policies. The PRESS-2 study (PEER Research on Ecosystem Service – Phase 2) provides...... such an analytical framework which enables the operationalization of the present scientific knowledge base of environmental data and models for application by the EU and Member States for mapping and assessment of ecosystem services. This study was structured along three strands of work: policy and scenario analysis......, mapping and valuation. Linking the maps of ecosystem service supply to monetary valuation allowed an analysis of the expected impact of policy measures on benefits derived from ecosystem services. The recreation case, which Marianne participated in, presents evidence that millions of people visited...

  15. A spatial assessment of ecosystem services in Europe - Phase II

    DEFF Research Database (Denmark)

    Maes, Joachim; Hauck, Jennifer; Paracchini,, Maria Luisa

    , mapping and valuation. Linking the maps of ecosystem service supply to monetary valuation allowed an analysis of the expected impact of policy measures on benefits derived from ecosystem services. The recreation case, which Marianne participated in, presents evidence that millions of people visited......Mainstreaming ecosystem services in EU decision making processes requires a solid conceptual and methodological framework for mapping and assessing ecosystem services that serve the multiple objectives addressed by policies. The PRESS-2 study (PEER Research on Ecosystem Service – Phase 2) provides...... such an analytical framework which enables the operationalization of the present scientific knowledge base of environmental data and models for application by the EU and Member States for mapping and assessment of ecosystem services. This study was structured along three strands of work: policy and scenario analysis...

  16. Project 8 Phase II: Improved beta decay electrons reconstruction

    Science.gov (United States)

    Guigue, Mathieu; Project 8 Collaboration

    2017-01-01

    The Project 8 collaboration aims to measure the absolute neutrino mass scale using a cyclotron radiation emission spectroscopy technique on the beta decays of tritium. The second phase of the project will measure a differential spectrum of tritium beta decays and extract the tritium endpoint value with an eV or sub-eV scale precision. Monoenergetic electrons emitted by gaseous 83mKr atoms can be used to determine the coefficient between the cyclotron frequency and the electron energy and to optimize the instrument configuration for the tritium measurement. We present the progress on the processing of the electron cyclotron radiation signal to reconstruct the beta decay spectrum of krypton and tritium.

  17. Thermal Performance of Microencapsulated Phase Change Material Survey

    Science.gov (United States)

    2008-03-01

    ER D C TR -0 8 -4 Basic Research/Military Construction Thermal Performance of Microencapsulated Phase Change Material Slurry Jorge L...distribution is unlimited. Basic Research/Military Construction ERDC TR-08-4 March 2008 Thermal Performance of Microencapsulated Phase Change... microencapsulated PCM (MPCM) slurries is enhanced significantly, even when using low volume fractions. MPCM slurries have potential to decrease costs and improve

  18. SDSS-II Supernova survey. An analysis of the largest sample of type IA supernovae and correlations with host-galaxy spectral properties

    Energy Technology Data Exchange (ETDEWEB)

    Wolf, Rachel C.; D’Andrea, Chris B.; Gupta, Ravi R.; Sako, Masao; Fischer, John A.; Kessler, Rick; Jha, Saurabh W.; March, Marisa C.; Scolnic, Daniel M.; Fischer, Johanna-Laina; Campbell, Heather; Nichol, Robert C.; Olmstead, Matthew D.; Richmond, Michael; Schneider, Donald P.; Smith, Mathew

    2016-04-20

    Using the largest single-survey sample of Type Ia supernovae (SNe Ia) to date, we study the relationship between properties of SNe Ia and those of their host galaxies, focusing primarily on correlations with Hubble residuals (HR). Our sample consists of 345 photometrically-classified or spectroscopicallyconfirmed SNe Ia discovered as part of the SDSS-II Supernova Survey (SDSS-SNS). This analysis utilizes host-galaxy spectroscopy obtained during the SDSS-I/II spectroscopic survey and from an ancillary program on the SDSS-III Baryon Oscillation Spectroscopic Survey (BOSS) that obtained spectra for nearly all host galaxies of SDSS-II SN candidates. In addition, we use photometric hostgalaxy properties from the SDSS-SNS data release (Sako et al. 2014) such as host stellar mass and star-formation rate. We confirm the well-known relation between HR and host-galaxy mass and find a 3.6σ significance of a non-zero linear slope. We also recover correlations between HR and hostgalaxy gas-phase metallicity and specific star-formation rate as they are reported in the literature. With our large dataset, we examine correlations between HR and multiple host-galaxy properties simultaneously and find no evidence of a significant correlation. We also independently analyze our spectroscopically-confirmed and photometrically-classified SNe Ia and comment on the significance of similar combined datasets for future surveys.

  19. Phase Equilibria and Transition in Mixtures of a Homopolymer and a Block Copolymer. II.

    Science.gov (United States)

    1983-01-26

    AD-A124 929 PHASE EQUILIBRIA AND TRANSITION IN MIXTURES OF A In- NOMOPOLYMER AND’A BLOCK..(U) CINCINNATI UNJY ON DEPT OF MATERIALS SCIENCE AND...REPORT NO. 7 v2 L Phase Equilibria and Transition in Mixtures of a Homopolymer and a Block Copolymer II. The Phase Diagram by R. J. Roe and W. C. Zin...homopolymers as in our systems. The phase equilibria at temperatures above the "pseudo-triple point" BCD can be interpreted in terms of the free energy of

  20. Mercury Phase II Study - Mercury Behavior in Salt Processing Flowsheet

    Energy Technology Data Exchange (ETDEWEB)

    Jain, V. [Savannah River Remediation, LLC., Aiken, SC (United States); Shah, H. [Savannah River Remediation, LLC., Aiken, SC (United States). Sludge and Salt Planning; Bannochie, C. J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Wilmarth, W. R. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-07-25

    Mercury (Hg) in the Savannah River Site Liquid Waste System (LWS) originated from decades of canyon processing where it was used as a catalyst for dissolving the aluminum cladding of reactor fuel. Approximately 60 metric tons of mercury is currently present throughout the LWS. Mercury has long been a consideration in the LWS, from both hazard and processing perspectives. In February 2015, a Mercury Program Team was established at the request of the Department of Energy to develop a comprehensive action plan for long term management and removal of mercury. Evaluation was focused in two Phases. Phase I activities assessed the Liquid Waste inventory and chemical processing behavior using a system by system review methodology and determined the speciation of the different mercury forms (Hg+, Hg++, elemental Hg, organomercury, and soluble versus insoluble mercury) within the LWS. The evaluation of the mercury behavior in the salt processing flowsheet indicates: • In the assembled Salt Batches 7, 8 and 9 in Tank 21, the total mercury is mostly soluble with methylmercury (MHg) contributing over 50% of the total mercury. Based on the analyses of samples from 2H Evaporator feed and drop tanks (Tanks 38/43), the source of MHg in Salt Batches 7, 8 and 9 can be attributed to the 2H evaporator concentrate used in assembling the salt batches. The 2H Evaporator is used to evaporate DWPF recycle water. • Comparison of data between Tank 21/49, Salt Solution Feed Tank (SSFT), Decontaminated Salt Solution Hold Tank (DSSHT), and Tank 50 samples suggests that the total mercury as well as speciated forms in the assembled salt batches in Tanks 21/49 pass through the Actinide Removal Process (ARP) / Modular Caustic Side Solvent Extraction Unit (MCU) process to Tank 50 with no significant change in the mercury chemistry. • In Tank 50, Decontaminated Salt Solution (DSS) from ARP/MCU is the major contributor to the total mercury including MHg. More information can be found about what

  1. OCCIDENTAL VERTICAL MODIFIED IN SITU PROCESS FOR THE RECOVERY OF OIL FROM OIL SHALE. PHASE II

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, Reid M.

    1980-09-01

    The progress presented in this report covers the period June 1, 1980 through August 31, 1980 under the work scope for.Phase II of the DOE/Occidental Oil Shale, Inc. (OOSI) Cooperative Agreement. The major activities at OOSI 1s Logan Wash site during the quarter were: mining the voids at all levels for Retorts 7, 8 and 8x; completing Mini-Retort (MR) construction; continuing surface facility construction; tracer testing the MR 1 s; conducting Retorts 7 & 8 related Rock Fragmentation tests; setting up and debugging the Sandia B-61 trailer; and preparing the Phase II instrumentation plan.

  2. RadSTraM: Radiological Source Tracking and Monitoring, Phase II Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Warren, Tracy A [ORNL; Walker, Randy M [ORNL; Hill, David E [ORNL; Gross, Ian G [ORNL; Smith, Cyrus M [ORNL; Abercrombie, Robert K [ORNL

    2008-12-01

    This report focuses on the technical information gained from the Radiological Source Tracking and Monitoring (RadSTraM) Phase II investigation and its implications. The intent of the RadSTraM project was to determine the feasibility of tracking radioactive materials in commerce, particularly International Atomic Energy Agency (IAEA) Category 3 and 4 materials. Specifically, Phase II of the project addressed tracking radiological medical isotopes in commerce. These categories of materials are susceptible to loss or theft but the problem is not being addressed by other agencies.

  3. ATLAS Calorimeters: Run-2 performance and Phase-II upgrade

    CERN Document Server

    Boumediene, Djamel Eddine; The ATLAS collaboration

    2017-01-01

    The ATLAS detector was designed and built to study proton-proton collisions produced at the LHC at centre-of-mass energies up to 14 TeV and instantaneous luminosities up to 10^{34} cm^{−2} s^{−1}. A liquid argon (LAr)-lead sampling calorimeter is employed as electromagnetic calorimeter and hadronic calorimter, except in the barrel region, where a scintillator-steel sampling calorimeter (TileCal) is used as hadronic calorimter. This presentation will give first an overview of the detector operation and data quality, as well as the achieved performance of the ATLAS calorimetry system. Additionally, the upgrade projects of the ATLAS calorimeter system for the high luminosity phase of the LHC (HL-LHC) will be presented. For the HL-LHC, the instantaneous luminosity is expected to increase up to L ≃ 7.5 × 10^{34} cm^{−2} s^{−1} and the average pile-up up to 200 interactions per bunch crossing. The major R&D item is the upgrade of the electronics for both LAr and Tile calorimeters in order to cope wit...

  4. The Phase II Upgrade of the ATLAS Calorimeter

    CERN Document Server

    Tartarelli, Giuseppe Francesco; The ATLAS collaboration

    2017-01-01

    This presentation will show the status of the upgrade projects of the ATLAS calorimeter system for the high luminosity phase of the LHC (HL-LHC). For the HL-LHC, the instantaneous luminosity is expected to increase up to L ≃ 7.5 × 1034 cm−2 s−1 and the average pile-up up to 200 interactions per bunch crossing. The Liquid Argon (LAr) calorimeter electronics will need to be replaced to cope with these challenging conditions: the expected radiation doses will indeed exceed the qualification range of the current readout system, and the upgraded trigger system will require much longer data storage in the electronics (up to 60 us), that the current system cannot sustain. The status of the R&D of the low-power ASICs (pre-amplifier, shaper, ADC, serializer and transmitters) and of the readout electronics design will be discussed. Moreover, a High Granularity Timing Detector (HGTD) is proposed to be added in front of the LAr calorimeters in the end-cap region (2.4 <|eta|< 4.2) for pile-up mitigation a...

  5. ATLAS calorimeters: Run-2 performances and Phase-II upgrades

    CERN Document Server

    Boumediene, Djamel Eddine; The ATLAS collaboration

    2017-01-01

    The ATLAS detector was designed and built to study proton-proton collisions produced at the LHC at centre-of-mass energies up to 14 TeV and instantaneous luminosities up to $10^{34} cm^{-2} s^{-1}$. A Liquid Argon-lead sampling (LAr) calorimeter is employed as electromagnetic and hadronic calorimeters, except in the barrel region, where a scintillator-steel sampling calorimeter (TileCal) is used as hadronic calorimeter. This presentation gives first an overview of the detector operation and data quality, as well as of the achieved performances of the ATLAS calorimetry system. Additionally the upgrade projects of the ATLAS calorimeter system for the high luminosity phase of the LHC (HL-LHC) are presented. For the HL-LHC, the instantaneous luminosity is expected to increase up to $L \\simeq 7.5 × 10^{34} cm^{-2} s^{-1}$ and the average pile-up up to 200 interactions per bunch crossing. The major R&D item is the upgrade of the electronics for both LAr and Tile calorimeters in order to cope with longer latenc...

  6. MHD coal combustor technology. Final report, phase II

    Energy Technology Data Exchange (ETDEWEB)

    1980-09-01

    The design, performance, and testing of a 20-MW coal combustor for scaleup to 50 MW for use in an MHD generator are described. The design incorporates the following key features: (1) a two-stage combustor with an intermediate slag separator to remove slag at a low temperture, thus minimizing enthalpy losses required for heating and vaporizing the slag; (2) a first-stage pentad (four air streams impinging on one coal stream) injector design with demonstrated efficient mixing, promoting high carbon burnout; (3) a two-section first-stage combustion chamber; the first stage using a thin slag-protected refractory layer and the second section using a thick refractory layer, both to minimize heat losses; (4) a refractory lining in the slag separator to minimize heat losses; (5) a second-stage combustor, which provided both de-swirl of the combustion products exiting from the slag separator and simple mixing of the vitiated secondary air and seed; (6) a dense-phase coal feed system to minimize cold carrier gas entering the first-stage combustors; (7) a dry seed injection system using pulverized K/sub 2/CO/sub 3/ with a 1% amorphous, fumed silicon dioxide additive to enhance flowability, resulting in rapid vaporization and ionization and ensuring maximum performance; and (8) a performance evaluation module (PEM) of rugged design based on an existing, successfully-fired unit. (WHK)

  7. The Phase-II ATLAS ITk Pixel Upgrade

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00349918; The ATLAS collaboration

    2017-01-01

    The entire tracking system of the ATLAS experiment will be replaced during the LHC Phase~2 shutdown (foreseen to take place around 2025) by an all-silicon detector called the ``ITk'' (Inner Tracker). The innermost portion of ITk will consist of a pixel detector with five layers in the barrel region and ring-shaped supports in the end-cap regions. It will be instrumented with new sensor and readout electronics technologies to improve the tracking performance and cope with the HL-LHC environment, which will be severe in terms of occupancy and radiation levels. The new pixel system could include up to 14 $\\mathrm{m^2}$ of silicon, depending on the final layout, which is expected to be decided in 2017. Several layout options are being investigated at the moment, including some with novel inclined support structures in the barrel end-cap overlap region and others with very long innermost barrel layers. Forward coverage could be as high as |eta| $<4$. Supporting structures will be based on low mass, highly stabl...

  8. Valve development for coal gasification plants: Phase I to Phase II transition. Quarterly technical program report, May--July 1978

    Energy Technology Data Exchange (ETDEWEB)

    Bellezza, D.

    1978-08-01

    This is the eighth in a series of Quarterly Technical Progress Reports relating to the Valve Development for Coal Gasification Plants Program. This document discusses engineering progress during the period of May to July 1978. The work described herein represents a continuation of the Phase I seat development effort for the Task III valve and the continuation of design engineering effort, necessary to prepare detail manufacturing drawings for use in the production of prototype valves during Phase II of this program. Work performed during this quarter consists of: valve design, thermal and stress analysis of valves, design detailing and specifications, quality assurance planning and various tests as outlined.

  9. Comparing acquired angioedema with hereditary angioedema (types I/II): findings from the Icatibant Outcome Survey.

    Science.gov (United States)

    Longhurst, H J; Zanichelli, A; Caballero, T; Bouillet, L; Aberer, W; Maurer, M; Fain, O; Fabien, V; Andresen, I

    2017-04-01

    Icatibant is used to treat acute hereditary angioedema with C1 inhibitor deficiency types I/II (C1-INH-HAE types I/II) and has shown promise in angioedema due to acquired C1 inhibitor deficiency (C1-INH-AAE). Data from the Icatibant Outcome Survey (IOS) were analysed to evaluate the effectiveness of icatibant in the treatment of patients with C1-INH-AAE and compare disease characteristics with those with C1-INH-HAE types I/II. Key medical history (including prior occurrence of attacks) was recorded upon IOS enrolment. Thereafter, data were recorded retrospectively at approximately 6-month intervals during patient follow-up visits. In the icatibant-treated population, 16 patients with C1-INH-AAE had 287 attacks and 415 patients with C1-INH-HAE types I/II had 2245 attacks. Patients with C1-INH-AAE versus C1-INH-HAE types I/II were more often male (69 versus 42%; P = 0·035) and had a significantly later mean (95% confidence interval) age of symptom onset [57·9 (51·33-64·53) versus 14·0 (12·70-15·26) years]. Time from symptom onset to diagnosis was significantly shorter in patients with C1-INH-AAE versus C1-INH-HAE types I/II (mean 12·3 months versus 118·1 months; P = 0·006). Patients with C1-INH-AAE showed a trend for higher occurrence of attacks involving the face (35 versus 21% of attacks; P = 0·064). Overall, angioedema attacks were more severe in patients with C1-INH-HAE types I/II versus C1-INH-AAE (61 versus 40% of attacks were classified as severe to very severe; P types I/II, respectively. © 2016 British Society for Immunology.

  10. Application of Bayesian hierarchical models for phase I/II clinical trials in oncology.

    Science.gov (United States)

    Yada, Shinjo; Hamada, Chikuma

    2017-03-01

    Treatment during cancer clinical trials sometimes involves the combination of multiple drugs. In addition, in recent years there has been a trend toward phase I/II trials in which a phase I and a phase II trial are combined into a single trial to accelerate drug development. Methods for the seamless combination of phases I and II parts are currently under investigation. In the phase II part, adaptive randomization on the basis of patient efficacy outcomes allocates more patients to the dose combinations considered to have higher efficacy. Patient toxicity outcomes are used for determining admissibility to each dose combination and are not used for selection of the dose combination itself. In cases where the objective is not to find the optimum dose combination solely for efficacy but regarding both toxicity and efficacy, the need exists to allocate patients to dose combinations with consideration of the balance of existing trade-offs between toxicity and efficacy. We propose a Bayesian hierarchical model and an adaptive randomization with consideration for the relationship with toxicity and efficacy. Using the toxicity and efficacy outcomes of patients, the Bayesian hierarchical model is used to estimate the toxicity probability and efficacy probability in each of the dose combinations. Here, we use Bayesian moving-reference adaptive randomization on the basis of desirability computed from the obtained estimator. Computer simulations suggest that the proposed method will likely recommend a higher percentage of target dose combinations than a previously proposed method.

  11. Travelling Wave Solutions to Stretched Beam's Equation: Phase Portraits Survey

    Institute of Scientific and Technical Information of China (English)

    Gambo Betchewe; Kuetche Kamgang Victor; Bouetou Bouetou Thomas; Timoleon Crepin Kofane

    2011-01-01

    In this paper, following the phase portraits analysis, we investigate the integrability of a system which physically describes the transverse oscillation of an elastic beam under end-thrust. As a result, we find that this system actually comprises two families of travelling waves: the sub- and super-sonic periodic waves of positive- and negative-definite velocities, respectively, and the localized sub-sonic loop-shaped waves of positive-definite velocity. Expressing the energy-like of this system while depicting its phase portrait dynamics, we show that these multivalued localized travelling waves appear as the boundary solutions to which the periodic travelling waves tend asymptotically.

  12. Curriculum for Evidence Based Medicine for MBBS II phase Graduates

    Directory of Open Access Journals (Sweden)

    Saxena R

    2014-12-01

    Full Text Available Evidence based medicine is the training of health care professionals to access, assess and apply the best scientific evidence to clinical practice. EBM is the conscientious, explicit and judicious use of current best evidence along with clinical expertise and patient values in making decisions about the case of individual patients. The current undergraduate curriculum of health profession is based on past knowledge accumulated for years. The scientific relevance of the mostly outdated information has never been questioned. The students passively absorb this available knowledge and apply it in their future professional life. There is no active learning on their part, by way of positive enquiry and critical analysis of the curriculum imposed on them. This has an undesirable impact on their competency as health professionals and the quality of the health care imparted by them. Hence there is need for emphasis on the teaching of EBM skills in undergraduate, postgraduate, and continuing medical education programs. Early introduction of EBM in the undergraduate medical curriculum, in the form of a short course, using various modes of instruction, enhances the competence of critical thinking and also influences change in attitude towards EBM positively in medical students. The EBM course is planned to introduce in the curriculum of medical undergraduates at the beginning of second phase when they enter clinical posting. Total number of student would be 100 per batch and the course duration will be of 1 year. Educational methods program incorporates multiple teaching methods like lectures, discussion sessions, demonstration, case based learning, timely feedback, real life exposure, role modeling and peer evaluation.

  13. NEWLY IDENTIFIED EXTENDED GREEN OBJECTS (EGOs) FROM THE SPITZER GLIMPSE II SURVEY. I. CATALOG

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Xi; Gan, Cong-Gui; Shen, Zhi-Qiang [Key Laboratory for Research in Galaxies and Cosmology, Shanghai Astronomical Observatory, Chinese Academy of Sciences, Shanghai 200030 (China); Ellingsen, Simon P.; Titmarsh, Anita [School of Mathematics and Physics, University of Tasmania, Hobart, Tasmania (Australia); He, Jin-Hua, E-mail: chenxi@shao.ac.cn [Key Laboratory for the Structure and Evolution of Celestial Objects, Yunnan Astronomical Observatory/National Astronomical Observatory, Chinese Academy of Sciences, P.O. Box 110, Kunming, 650011 Yunnan Province (China)

    2013-05-01

    We have produced a catalog containing 98 newly identified massive young stellar object (MYSO) candidates associated with ongoing outflows (known as extended green objects, or EGOs). These have been identified from the Spitzer Galactic Legacy Infrared Mid-Plane Survey Extraordinaire (GLIMPSE) II data set and our new identifications increase the number of known EGOs to {approx}400 in our Galaxy, adding to the {approx}300 previously identified EGOs reported by Cyganowski et al. from the GLIMPSE I survey. The high detection rate ({approx}70%) of 95 GHz class I methanol masers achieved in a survey toward 57 of these new EGOs with the Mopra 22 m radio telescope demonstrates that the new EGOs are associated with outflows. Investigations of the mid-infrared properties and physical associations with other star formation tracers (e.g., infrared dark clouds, class I and II methanol masers, and millimeter Bolocam Galactic Plane Survey sources) reveal that the newly identified EGOs are very similar in nature to those in the sample of Cyganowski et al. All of the observational evidence supports the hypothesis that EGOs correspond to MYSOs at the earliest evolutionary stage, with ongoing outflow activity, and active rapid accretion.

  14. An FPGA-based trigger for the phase II of the MEG experiment

    Energy Technology Data Exchange (ETDEWEB)

    Baldini, A. [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Bemporad, C.; Cei, F. [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Dipartimento di Fisica, Università di Pisa (Italy); Galli, L.; Grassi, M.; Morsani, F. [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Nicolò, D., E-mail: donato.nicolo@pi.infn.it [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Dipartimento di Fisica, Università di Pisa (Italy); Ritt, S. [Paul Scherrer Institut, Villigen AG (Switzerland); Venturini, M. [Istituto Nazionale di Fisica Nucleare, Pisa (Italy); Scuola Normale Superiore, Pisa (Italy)

    2016-07-11

    For the phase II of MEG, we are going to develop a combined trigger and DAQ system. Here we focus on the former side, which operates an on-line reconstruction of detector signals and event selection within 450 μs from event occurrence. Trigger concentrator boards (TCB) are under development to gather data from different crates, each connected to a set of detector channels, to accomplish higher-level algorithms to issue a trigger in the case of a candidate signal event. We describe the major features of the new system, in comparison with phase I, as well as its performances in terms of selection efficiency and background rejection. - Highlights: • A new, two-level trigger scheme for the phase-II of the MEG experiment is presented. • Improvements with respect to phase-I are underlined. • The role of detector upgrades and the use of a new generation of FPGA as well are emphasized.

  15. [Orthodontics in general practice 3. Angle Class II/1 malocclusion: one-phase treatment treatment preferred to two-phase treatment

    NARCIS (Netherlands)

    Kuijpers, M.A.; Kuijpers-Jagtman, A.M.

    2008-01-01

    With regard to the optimal treatment timing for children with an Angle Class II division 1 malocclusion, there is an ongoing controversy on the effectiveness of a two-phase or a one-phase therapy. Two-phase treatment involves a first phase to correct the jaw relationship starting at the age of 7 to

  16. Southwest Regional Partnership on Carbon Sequestration Phase II

    Energy Technology Data Exchange (ETDEWEB)

    James Rutledge

    2011-02-01

    The Southwest Regional Partnership (SWP) on Carbon Sequestration designed and deployed a medium-scale field pilot test of geologic carbon dioxide (CO2) sequestration in the Aneth oil field. Greater Aneth oil field, Utah's largest oil producer, was discovered in 1956 and has produced over 455 million barrels of oil (72 million m3). Located in the Paradox Basin of southeastern Utah, Greater Aneth is a stratigraphic trap producing from the Pennsylvanian Paradox Formation. Because it represents an archetype oil field of the western U.S., Greater Aneth was selected as one of three geologic pilots to demonstrate combined enhanced oil recovery (EOR) and CO2 sequestration under the auspices of the SWP on Carbon Sequestration, sponsored by the U.S. Department of Energy. The pilot demonstration focuced on the western portion of the Aneth Unit as this area of the field was converted from waterflood production to CO2 EOR starting in late 2007. The Aneth Unit is in the northwestern part of the field and has produced 149 million barrels (24 million m3) of the estimated 450 million barrels (71.5 million m3) of the original oil in place - a 33% recovery rate. The large amount of remaining oil makes the Aneth Unit ideal to demonstrate both CO2 storage capacity and EOR by CO2 flooding. This report summarizes the geologic characterization research, the various field monitoring tests, and the development of a geologic model and numerical simulations conducted for the Aneth demonstration project. The Utah Geological Survey (UGS), with contributions from other Partners, evaluated how the surface and subsurface geology of the Aneth Unit demonstration site will affect sequestration operations and engineering strategies. The UGS-research for the project are summarized in Chapters 1 through 7, and includes (1) mapping the surface geology including stratigraphy, faulting, fractures, and deformation bands, (2) describing the local Jurassic and Cretaceous stratigraphy, (3) mapping the

  17. Structure of intermediate phase II of LiNH2 under high pressure.

    Science.gov (United States)

    Yamawaki, Hiroshi; Fujihisa, Hiroshi; Gotoh, Yoshito; Nakano, Satoshi

    2014-08-21

    A new intermediate phase (phase II) was found between phases I and III in LiNH2 in the pressure range of 10 to 13 GPa through the analysis of infrared and powder X-ray diffraction measurements to 25 GPa at room temperature. This result agreed with the prediction of a stable phase between phases I and III through theoretical calculations. Powder X-ray diffraction measurement and DFT calculation showed that this phase has a monoclinic structure with space group C2/c (Z = 8), which is the same structure as that of a slightly tilted crystal lattice of the Fddd structural model. The enthalpy of the C2/c structure was also found to be almost the same as that of the Fddd structure.

  18. Removal of Cadmium(II and Lead(II ions from aqueous phase on sodic bentonite

    Directory of Open Access Journals (Sweden)

    Luz Stella Gaona Galindo

    2013-04-01

    Full Text Available This paper describes the adsorption of Cd2+and Pb2+ions using sodic bentonite clay type Fluidgel modified. The Fluidgelbefore and after chemical modification and thermal activation was characterized by different techniques including X-ray diffraction, thermal analysis, Fourier transform infrared, surface area, helium pycnometry, cation exchange capacity and scanning electron microscopy. Pseudo-first order, pseudo-second order and intra-particle diffusion models were used to analyze the kinetic curves. Equilibrium data were analyzed using Langmuir and Freundlich models. The thermodynamic study indicated that lead adsorption process is endothermic and interactions between clays and solutions of lead occurred spontaneously, while cadmium adsorption revealed an exothermic and spontaneous nature. The maximum removal efficiencies were 97.62% for Cd(II using Fluidgelmodified chemically and 91.08% for lead by Fluidgel modified chemical and thermally.

  19. 40 CFR 73.10 - Initial allocations for phase I and phase II.

    Science.gov (United States)

    2010-07-01

    ... State name Plant name Boiler Column A final phase 1 allocation Column B auction and sales reserve... Plant name Unit Allowances for 2000 through 2009column (A) Allowances for 2010 and thereaftercolumn (B...

  20. A survey of large N continuum phase transitions

    CERN Document Server

    Narayanan, R

    2007-01-01

    The main focus of this talk is the physics of large N QCD on a continuum torus. A cascade of phase transitions associated with the breaking of U(1) symmetries will be discussed. The continuum Wilson loop as a function of its area will be discussed along with its universality properties and the associated double scaling limit. Some recent progress in twisted Eguchi-Kawai is presented. Gauge field topology and $\\theta$ vacuua are also discussed in the context of large N gauge theories. Phase transitions in 2D large N principal chiral models are compared with similar transitions in large $N$ gauge theories. Finally, connections to some topics in string theory and gravity are briefly described.

  1. Specific threonine-4 phosphorylation and function of RNA polymerase II CTD during M phase progression.

    Science.gov (United States)

    Hintermair, Corinna; Voß, Kirsten; Forné, Ignasi; Heidemann, Martin; Flatley, Andrew; Kremmer, Elisabeth; Imhof, Axel; Eick, Dirk

    2016-06-06

    Dynamic phosphorylation of Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 heptad-repeats in the C-terminal domain (CTD) of the large subunit coordinates progression of RNA polymerase (Pol) II through the transcription cycle. Here, we describe an M phase-specific form of Pol II phosphorylated at Thr4, but not at Tyr1, Ser2, Ser5, and Ser7 residues. Thr4 phosphorylated Pol II binds to centrosomes and midbody and interacts with the Thr4-specific Polo-like kinase 1. Binding of Pol II to centrosomes does not require the CTD but may involve subunits of the non-canonical R2TP-Prefoldin-like complex, which bind to and co-localize with Pol II at centrosomes. CTD Thr4 mutants, but not Ser2 and Ser5 mutants, display severe mitosis and cytokinesis defects characterized by multipolar spindles and polyploid cells. We conclude that proper M phase progression of cells requires binding of Pol II to centrosomes to facilitate regulation of mitosis and cytokinesis in a CTD Thr4-P dependent manner.

  2. Pentostatin in T-cell malignancies - a phase II trial of the EORTC

    NARCIS (Netherlands)

    Ho, AD; Suciu, S; Stryckmans, P; De Cataldo, F; Willemze, R; Thaler, J; Peetermans, M; Dohner, H; Solbu, G; Dardenne, M; Zittoun, R

    1999-01-01

    Purpose: Within this phase II EORTC trial, we have investigated the safety and efficacy of pentostatin in lymphoid malignancies. We have previously reported the results in T- and B-cell prolymphocytic leukemia, B-cell chronic lymphocytic leukemia (B-CLL) and hairy cell leukemia. This report focuses

  3. Webcam Delivery of the Camperdown Program for Adolescents Who Stutter: A Phase II Trial

    Science.gov (United States)

    Carey, Brenda; O'Brian, Sue; Lowe, Robyn; Onslow, Mark

    2014-01-01

    Purpose: This Phase II clinical trial examined stuttering adolescents' responsiveness to the Webcam-delivered Camperdown Program. Method: Sixteen adolescents were treated by Webcam with no clinic attendance. Primary outcome was percentage of syllables stuttered (%SS). Secondary outcomes were number of sessions, weeks and hours to maintenance,…

  4. Pentostatin in T-cell malignancies - a phase II trial of the EORTC

    NARCIS (Netherlands)

    Ho, AD; Suciu, S; Stryckmans, P; De Cataldo, F; Willemze, R; Thaler, J; Peetermans, M; Dohner, H; Solbu, G; Dardenne, M; Zittoun, R

    1999-01-01

    Purpose: Within this phase II EORTC trial, we have investigated the safety and efficacy of pentostatin in lymphoid malignancies. We have previously reported the results in T- and B-cell prolymphocytic leukemia, B-cell chronic lymphocytic leukemia (B-CLL) and hairy cell leukemia. This report focuses

  5. Phase II study of ACNU in non-small-cell lung cancer: EORTC study 08872

    NARCIS (Netherlands)

    A.S.Th. Planting (André); A. Ardizzoni (A.); J. Estapé (J.); G. Giaccone (Giuseppe); G.V. Scagliotti (Giorgio); T.A.W. Splinter (Ted); A. Kirkpatrick (A.); O. Dalesio (O.); J.G. Mcvie (John Gordon)

    1991-01-01

    textabstractA total of 62 patients with metastatic or locally advanced non-small-cell lung cancer were entered in a phase II study of ACNU. Initially, the drug was given i. v. at a dose of 100 mg/m2 every 6 weeks, but due to observed haematological side effects in chemotherapy-pretreated patients,

  6. Deconjugation Kinetics of Glucuronidated Phase II Flavonoid Metabolites by B-glucuronidase from Neutrophils

    NARCIS (Netherlands)

    Bartholomé, R.; Haenen, G.; Hollman, P.C.H.; Bast, A.; Dagnelie, P.C.; Roos, D.; Keijer, J.; Kroon, P.A.; Needs, P.W.; Arts, I.C.W.

    2010-01-01

    Flavonoids are inactivated by phase II metabolism and occur in the body as glucuronides. Mammalian ß-glucuronidase released from neutrophils at inflammatory sites may be able to deconjugate and thus activate flavonoid glucuronides. We have studied deconjugation kinetics and pH optimum for four sourc

  7. The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential

    NARCIS (Netherlands)

    Zanden, van J.J.; Woude, van der H.; Vaessen, J.; Usta, M.; Wortelboer, H.M.; Cnubben, N.H.P.; Rietjens, I.M.C.M.

    2007-01-01

    The present study characterises the effect of phase II metabolism, especially methylation and glucuronidation, of the model flavonoid quercetin on its capacity to inhibit human MRP1 and MRP2 activity in Sf9 inside-out vesicles. The results obtained reveal that 3¿-O-methylation does not affect the MR

  8. A phase II trial of chimeric monoclonal antibody G250 for advanced renal cell carcinoma patients.

    NARCIS (Netherlands)

    Bleumer, I.; Knuth, A.; Oosterwijk, E.; Hofmann, R.; Varga, Z.; Lamers, C.B.H.W.; Kruit, W.; Melchior, S.; Mala, C.; Ullrich, S.; Mulder, P.; Mulders, P.F.A.; Beck, J.L.M.

    2004-01-01

    Chimeric monoclonal antibody G250 (WX-G250) binds to a cell surface antigen found on >90% of renal cell carcinoma (RCC). A multicentre phase II study was performed to evaluate the safety and efficacy of WX-G250 in metastatic RCC (mRCC) patients. In all, 36 patients with mRCC were included. WX-G250 w

  9. Treatment of malignant pleural mesothelioma with carboplatin, liposomized doxorubicin, and gemcitabine: a phase II study

    DEFF Research Database (Denmark)

    Hillerdal, G.; Sundstrom, S.; Riska, H.

    2008-01-01

    BACKGROUND: Malignant pleural mesothelioma has a poor prognosis and there is limited effect of treatment. The Nordic Mesothelioma groups decided in the year 2000 to investigate a combination of liposomized doxorubicin, carboplatin, and gemcitabine for this disease in a phase II study. METHODS: From...

  10. 76 FR 55947 - Industrial Relations Promotion Project, Phase II in Vietnam

    Science.gov (United States)

    2011-09-09

    ... of the Secretary Industrial Relations Promotion Project, Phase II in Vietnam AGENCY: Bureau of... funded.. DAI, through its Industrial Relations Promotion Project (IRRP), is the only organization that... disputes and sound industrial relations by developing approaches in cooperation with trade unions/worker...

  11. Washington Phase II Fish Diversion Screen Evaluations in the Yakima River Basin, 1998.

    Energy Technology Data Exchange (ETDEWEB)

    Blanton, S.L.; McMichael, Geoffrey A.; Neitzel, D.A.

    1999-12-01

    Pacific Northwest National Laboratory (PNNL) evaluated 19 Phase II screen sites in the Yakima River Basin as part of a multi-year study for the Bonneville Power Administration (BPA) on the effectiveness of fish screening devices. The sites were examined to determine if they were being effectively operated and maintained to provide fish a safe, efficient return to the Yakima River.

  12. Recombinant human interleukin 6 in metastatic renal cell cancer : A phase II trial

    NARCIS (Netherlands)

    Stouthard, JML; Goey, H; deVries, EGE; deMulder, PH; Groenewegen, A; Stoter, G; Sauerwein, HP; Bakker, PJM; Veenhof, CHN

    A phase II trial investigating the anti-tumour effects of recombinant human interleukin 6 (rhlL-6) in patients with metastatic renal cell cancer was carried out. RhIL-6 (150 mu g) was administered as a daily subcutaneous injection for 42 consecutive days on an outpatient basis. Forty-nine patients

  13. Enzalutamide monotherapy: Phase II study results in patients with hormone-naive prostate cancer

    DEFF Research Database (Denmark)

    Tombal, Bertrand; Borre, Michael; Rathenborg, Per Zier;

    2013-01-01

    al, N Engl J Med 2012;367:1187). Compared with bicalutamide in nonclinical studies, enzalutamide had higher androgen receptor– binding affinity, prevented nuclear translocation, showed no DNA binding, and induced apoptosis (Tran et al, Science 2009;324:787). In contrast to previous phase II and III...

  14. Mechanisms of toxic action of the flavonoid quercetin and its phase II metabolites

    NARCIS (Netherlands)

    Woude, van der H.

    2006-01-01

    During and after absorption in the intestine, quercetin is extensively metabolised by the phase II biotransformation system. Because the biological activity of flavonoids is dependent on the number and position of free hydroxyl groups, a first objective of this thesis was to investigate the conseque

  15. The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential

    NARCIS (Netherlands)

    Zanden, J.J. van; Woude, H. van der; Vaessen, J.; Usta, M.; Wortelboer, H.M.; Cnubben, N.H.P.; Rietjens, I.M.C.M.

    2007-01-01

    The present study characterises the effect of phase II metabolism, especially methylation and glucuronidation, of the model flavonoid quercetin on its capacity to inhibit human MRP1 and MRP2 activity in Sf9 inside-out vesicles. The results obtained reveal that 3′-O-methylation does not affect the MR

  16. Phase II study of E7070 in patients with metastatic melanoma.

    NARCIS (Netherlands)

    Smyth, J.F.; Aamdal, S.; Awada, A.; Dittrich, C.; Caponigro, F.; Schoffski, P.; Gore, M.; Lesimple, T.; Djurasinovic, N.; Baron, B.; Ravic, M.; Fumoleau, P.; Punt, C.J.A.

    2005-01-01

    E7070 is a synthetic chloro-indolyl sulphonamide that is being developed as an anti cancer agent. In this phase II study, 28 patients with metastatic melanoma received 700 mg/m(2) of E7070 as a 60-min infusion repeated every 3 weeks. Although therapy was well tolerated, with one patient receiving 14

  17. Regulation of phase II enzymes by genistein and daidzein in male and female Swiss Webster mice.

    Science.gov (United States)

    Froyen, Erik B; Reeves, Jaime L Rudolf; Mitchell, Alyson E; Steinberg, Francene M

    2009-12-01

    The consumption of soy and soy isoflavones has been associated with a decreased risk of certain cancers. A factor contributing to this dietary chemoprevention is the activity of phase I and II biotransformation enzymes. This study evaluated the hypothesis that dietary soy isoflavones will increase hepatic and extrahepatic quinone reductase (QR), UDP-glucuronosyltransferase (UGT), and glutathione S-transferase (GST) phase II enzyme activities, under short-term feeding and basal (non-pharmacologic-induced) conditions. Male and female Swiss Webster mice were fed for 1, 3, 5, or 7 days of one of four treatments: control (casein AIN-93G) or control supplemented with flavone (positive control), genistein, or daidzein aglycones at 1,500 mg/kg of diet. QR activity was increased by daidzein in the liver, by both isoflavones in the kidney and small intestine, and by genistein in the heart. Genistein and daidzein slightly decreased UGT activities in some tissues. Liver GST activity was decreased by genistein in females. In contrast, genistein and daidzein increased kidney GST activity. In general, the greatest effects of isoflavones on phase II enzymes were observed in liver and kidney tissues, occurring at day 3, and peaking at day 5. Sex effects in the liver and kidney included females exhibiting higher QR activities and males exhibiting higher UGT and GST activities. In conclusion, individual soy isoflavones modulate phase II enzymes in mice under short-term feeding and basal conditions. This study provides insights into the actions of isolated isoflavones in mice.

  18. Recombinant human interleukin 6 in metastatic renal cell cancer : A phase II trial

    NARCIS (Netherlands)

    Stouthard, JML; Goey, H; deVries, EGE; deMulder, PH; Groenewegen, A; Stoter, G; Sauerwein, HP; Bakker, PJM; Veenhof, CHN

    1996-01-01

    A phase II trial investigating the anti-tumour effects of recombinant human interleukin 6 (rhlL-6) in patients with metastatic renal cell cancer was carried out. RhIL-6 (150 mu g) was administered as a daily subcutaneous injection for 42 consecutive days on an outpatient basis. Forty-nine patients w

  19. Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin

    NARCIS (Netherlands)

    de Jong, RS; Mulder, NH; Uges, DRA; Sleijfer, DT; Hoppener, FJP; Groen, HJM; Willemse, PHB; van der Graaf, WTA; de Vries, EGE

    We conducted a phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin. Fostriecin was administered intravenously over 60 min on days 1-5 at 4-week intervals. Dose was escalated from 2 mg m(-2) day(-1) to 20 mg m(-2) day(-1) in 20 patients. Drug pharmacokinetics was

  20. Etoposide in malignant pleural mesothelioma : Two phase II trials of the EORTC Lung Cancer Cooperative Group

    NARCIS (Netherlands)

    Sahmoud, T; Postmus, PE; van Pottelsberghe, C; Mattson, K; Tammilehto, L; Splinter, TAW; Planting, AST; Sutedja, T; van Pawel, J; van Zandwijk, N; Baas, P; Roozendaal, KJ; Schrijver, M; Kirkpatrick, A; Van Glabbeke, M; Ardizzoni, A; Giaccone, G

    1997-01-01

    Intravenous and oral etoposide (VP 16-213) were tested in two sequential phase II trials in chemotherapy-naive patients with malignant pleural mesothelioma. In the first trial, etoposide was given intravenously (i.v.) at a dose of 150 mg/m(2) on days 1, 3 and 5 every 3 weeks. The second trial invest

  1. The Phase-II ATLAS Pixel Tracker Upgrade: Layout and Mechanics

    CERN Document Server

    Sharma, Abhishek; The ATLAS collaboration

    2016-01-01

    In early 2017 a new layout will be decided for the ATLAS experiment as it undergoes an upgrade of its tracking detector during the Phase-II LHC shutdown, to better take advantage of the increased luminosity of the HL-LHC. The various layouts are described and a description of the supporting structures are presented, along with results from testing of prototypes.

  2. Definition of the Semisubmersible Floating System for Phase II of OC4

    Energy Technology Data Exchange (ETDEWEB)

    Robertson, A.; Jonkman, J.; Masciola, M.; Song, H.; Goupee, A.; Coulling, A.; Luan, C.

    2014-09-01

    Phase II of the Offshore Code Comparison Collaboration Continuation (OC4) project involved modeling of a semisubmersible floating offshore wind system as shown below. This report documents the specifications of the floating system, which were needed by the OC4 participants for building aero-hydro-servo-elastic models.

  3. NATO/CCMS PILOT STUDY CLEAN PRODUCTS AND PROCESSES (PHASE II) 2003 ANNUAL REPORT

    Science.gov (United States)

    The 6th annual meeting of the NATO CCMS Pilot Study, Clean Products and Processes, was held in Cetraro, Italy, from May 11 to 15, 2003. This was also the first meeting of its Phase II study. 24 country representatives attended this meeting. This meeting was very ably run by th...

  4. TA 55 Reinvestment Project II Phase C Update Project Status May 23, 2017

    Energy Technology Data Exchange (ETDEWEB)

    Giordano, Anthony P. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-05-25

    The TA-55 Reinvestment Project (TRP) II Phase C is a critical infrastructure project focused on improving safety and reliability of the Los Alamos National Laboratory (LANL) TA-55 Complex. The Project recapitalizes and revitalizes aging and obsolete facility and safety systems providing a sustainable nuclear facility for National Security Missions.

  5. Development and Validation of Methodology to Model Flow in Ventilation Systems Commonly Found in Nuclear Facilities - Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Strons, Philip [Argonne National Lab. (ANL), Argonne, IL (United States); Bailey, James L. [Argonne National Lab. (ANL), Argonne, IL (United States); Davis, John [Argonne National Lab. (ANL), Argonne, IL (United States); Grudzinski, James [Argonne National Lab. (ANL), Argonne, IL (United States); Hlotke, John [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-03-01

    In this report we present the results of the Phase II analysis and testing of the flow patterns encountered in the Alpha Gamma Hot Cell Facility (AGHCF), as well as the results from an opportunity to expand upon field test work from Phase I by the use of a Class IIIb laser. The addition to the Phase I work is covered before proceeding to the results of the Phase II work, followed by a summary of findings.

  6. A survey of weak MgII absorbers at redshift =1.78

    CERN Document Server

    Lynch, R S; Kim, T S; Lynch, Ryan S.; Charlton, Jane C.; Kim, Tae-Sun

    2006-01-01

    The exact nature of weak MgII absorbers (those with W_r(2796) < 0.3 A) is a matter of debate, but most are likely related to areas of local star formation or supernovae activity outside of giant galaxies. Using 18 QSO spectra obtained with the Ultra-Violet Echelle Spectrograph (UVES) on the Very Large Telescope (VLT), we have conducted a survey for weak MgII absorbers at 1.4 < z < 2.4. We searched a redshift path length of 8.51, eliminating regions badly contaminated by atmospheric absorption so that the survey is close to 100% complete to W_r(2796) = 0.02 A. We found a total of 9 weak absorbers, yielding a number density of absorbers of dN/dz = 1.06 +/- 0.12 for 0.02 <= W_r(2796) < 0.3 A. Narayanan et al. (2005) found dN/dz = 1.00 +/- 0.20 at 0 < z < 0.3 and Churchill et al. (1999) found dN/dz = 1.74 +/- 0.10 at 0.4 < z < 1.4. Therefore, the population of weak MgII absorbers appears to peak at z~1. We explore the expected evolution of the absorber population subject to a changing e...

  7. SDSS-II Supernova Survey: An Analysis of the Largest Sample of Type Ia Supernovae and Correlations with Host-Galaxy Spectral Properties

    CERN Document Server

    Wolf, Rachel C; Gupta, Ravi R; Sako, Masao; Fischer, John A; Kessler, Rick; Jha, Saurabh W; March, Marisa C; Scolnic, Daniel M; Fischer, Johanna-Laina; Campbell, Heather; Nichol, Robert C; Olmstead, Matthew D; Richmond, Michael; Schneider, Donald P; Smith, Mathew

    2016-01-01

    Using the largest single-survey sample of Type Ia supernovae (SNe Ia) to date, we study the relationship between properties of SNe Ia and those of their host galaxies, focusing primarily on correlations with Hubble residuals (HR). Our sample consists of 345 photometrically-classified or spectroscopically-confirmed SNeIa discovered as part of the SDSS-II Supernova Survey (SDSS-SNS). This analysis utilizes host-galaxy spectroscopy obtained during the SDSS-I/II spectroscopic survey and from an ancillary program on the SDSS-III Baryon Oscillation Spectroscopic Survey (BOSS) that obtained spectra for nearly all host galaxies of SDSS-II SN candidates. In addition, we use photometric host-galaxy properties from the SDSS-SNS data release (Sako et al. 2014) such as host stellar mass and star-formation rate. We confirm the well-known relation between HR and host-galaxy mass and find a 3.6{\\sigma} significance of a non-zero linear slope. We also recover correlations between HR and host-galaxy gas-phase metallicity and s...

  8. Cosmology with Photometrically-Classified Type Ia Supernovae from the SDSS-II Supernova Survey

    CERN Document Server

    Campbell, Heather; Nichol, Robert C; Sako, Masao; Smith, Mathew; Lampeitl, Hubert; Olmstead, Matthew D; Bassett, Bruce; Biswas, Rahul; Brown, Peter; Cinabro, David; Dawson, Kyle S; Dilday, Ben; Foley, Ryan J; Frieman, Joshua A; Garnavich, Peter; Hlozek, Renee; Jha, Saurabh W; Kuhlmann, Steve; Kunz, Martin; Marriner, John; Miquel, Ramon; Richmond, Michael; Riess, Adam; Schneider, Donald P; Sollerman, Jesper; Taylor, Matt; Zhao, Gong-Bo

    2012-01-01

    We present the cosmological analysis of 752 photometrically-classified Type Ia Supernovae (SNe Ia) obtained from the full Sloan Digital Sky Survey II (SDSS-II) Supernova (SN) Survey, supplemented with host-galaxy spectroscopy from the SDSS-III Baryon Oscillation Spectroscopic Survey (BOSS). Our photometric-classification method is based on the SN typing technique of Sako et al. (2011), aided by host galaxy redshifts (0.05

  9. First-Year Spectroscopy for the SDSS-II Supernova Survey

    CERN Document Server

    Zheng, Chen; Sako, Masao; Marriner, John; Bassett, Bruce; Becker, Andrew; Choi, Changsu; Cinabro, David; DeJongh, Fritz; Depoy, Darren L; Dilday, Ben; Doi, Mamoru; Frieman, Joshua A; Garnavich, Peter M; Hogan, Craig J; Holtzman, Jon; Im, Myungshin; Jha, Saurabh; Kessler, Richard; Konishi, Kohki; Lampeitl, Hubert; Marshall, Jennifer L; McGinnis, David; Miknaitis, Gajus; Nichol, Robert C; Prieto, Jose Luis; Riess, Adam G; Richmond, Michael W; Schneider, Donald P; Smith, Mathew; Takanashi, Naohiro; Tokita, Kouichi; van der Heyden, Kurt; Yasuda, Naoki; Assef, Roberto J; Barentine, John; Bender, Ralf; Blandford, Roger D; Bremer, Malcolm; Brewington, Howard; Collins, Chris A; Crotts, Arlin; Dembicky, Jack; Eastman, Jason; Edge, Alastair; Elson, Ed; Eyler, Michael E; Filippenko, Alexei V; Foley, Ryan J; Frank, Stephan; Goobar, Ariel; Harvanek, Michael; Hopp, Ulrich; Ihara, Yutaka; Kahn, Steven; Ketzeback, William; Kleinman, Scott J; Kollatschny, Wolfram; Krzesiński, Jurek; Leloudas, Giorgos; Long, Daniel C; Lucey, John; Malanushenko, Elena; Malanushenko, Viktor; McMillan, Russet J; Morgan, Christopher W; Morokuma, Tomoki; Nitta, Atsuko; Ostman, Linda; Pan, Kaike; Romer, A Kathy; Saurage, Gabrelle; Schlesinger, Katie; Snedden, Stephanie A; Sollerman, Jesper; Stritzinger, Maximilian; Watson, Linda C; Watters, Shannon; Wheeler, J Craig; York, Donald

    2008-01-01

    This paper presents spectroscopy of supernovae discovered in the first season of the Sloan Digital Sky Survey-II Supernova Survey. This program searches for and measures multi-band light curves of supernovae in the redshift range z = 0.05 - 0.4, complementing existing surveys at lower and higher redshifts. Our goal is to better characterize the supernova population, with a particular focus on SNe Ia, improving their utility as cosmological distance indicators and as probes of dark energy. Our supernova spectroscopy program features rapid-response observations using telescopes of a range of apertures, and provides confirmation of the supernova and host-galaxy types as well as precise redshifts. We describe here the target identification and prioritization, data reduction, redshift measurement, and classification of 129 SNe Ia, 16 spectroscopically probable SNe Ia, 7 SNe Ib/c, and 11 SNe II from the first season. We also describe our efforts to measure and remove the substantial host galaxy contamination existi...

  10. First-Year Spectroscopy for the SDSS-II Supernova Survey

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Chen; Romani, Roger W.; Sako, Masao; Marriner, John; Bassett, Bruce; Becker, Andrew; Choi, Changsu; Cinabro, David; DeJongh, Fritz; Depoy, Darren L.; Dilday, Ben; Doi, Mamoru; Frieman, Joshua A.; Garnavich, Peter M.; Hogan, Craig J.; Holtzman, Jon; Im, Myungshin; Jha, Saurabh; Kessler, Richard; Konishi, Kohki; Lampeitl, Hubert

    2008-03-25

    This paper presents spectroscopy of supernovae discovered in the first season of the Sloan Digital Sky Survey-II Supernova Survey. This program searches for and measures multi-band light curves of supernovae in the redshift range z = 0.05-0.4, complementing existing surveys at lower and higher redshifts. Our goal is to better characterize the supernova population, with a particular focus on SNe Ia, improving their utility as cosmological distance indicators and as probes of dark energy. Our supernova spectroscopy program features rapid-response observations using telescopes of a range of apertures, and provides confirmation of the supernova and host-galaxy types as well as precise redshifts. We describe here the target identification and prioritization, data reduction, redshift measurement, and classification of 129 SNe Ia, 16 spectroscopically probable SNe Ia, 7 SNe Ib/c, and 11 SNe II from the first season. We also describe our efforts to measure and remove the substantial host galaxy contamination existing in the majority of our SN spectra.

  11. Phase I and II feasibility study report for the 300-FF-5 operable unit

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-12-31

    The purpose of this Phase I/II feasibility study is to assemble and screen a list of alternatives for remediation of the 300-FF-5 operable site on the Hanford Reservation. This screening is based on information gathered in the Phase I Remedial Investigation (RI) and on currently available information on remediation technologies. The alternatives remaining after screening provide a range of response actions for remediation. In addition, key data needs are identified for collection during a Phase II RI (if necessary). This Phase I/II FS represents a primary document as defined by the Tri-Party Agreement, but will be followed by a Phase III FS that will further develop the alternatives and provide a detailed evaluation of them. The following remedial action objectives were identified for the 300-FF-5 operable unit: Limit current human exposure to contaminated groundwater in the unit; Limit discharge of contaminated groundwater to the Columbia River; Reduce contaminant concentrations in groundwater below acceptable levels by the year 2018.

  12. Identification of hazards in non-nuclear power plants. Volume II. Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Fell, R.W.

    1979-08-01

    This study extends the Phase I study to also include a hazards evaluation for two new emerging coal power plant technologies: coal fired atmospheric fluidized bed and pressurized fluidized bed power generating systems. The study also considers the sensitivity of the hazards ranking for all the non-nuclear power plants to the effects of population density, mode of plant operation, technical changes, location and environmental (temperature) effects. Information is provided under the following section headings: background; environmental and public health concerns associated with fluidized-bed combustion power plants; description of a conceptual atmospheric fluidized-bed power plant; pressurized fluidized-bed combustion combined cycle (PFBCC) power plant; hazard ranking and risk assessment for non-nuclear power plants; and, hazards sensitivity analysis.

  13. Phased Retrofits in Existing Homes in Florida Phase II. Shallow Plus Retrofits

    Energy Technology Data Exchange (ETDEWEB)

    Sutherland, K. [Building America Partnership for Improved Residential Construction, Cocoa, FL (United States); Parker, D. [Building America Partnership for Improved Residential Construction, Cocoa, FL (United States); Martin, E. [Building America Partnership for Improved Residential Construction, Cocoa, FL (United States); Chasar, D. [Building America Partnership for Improved Residential Construction, Cocoa, FL (United States); Amos, B. [Building America Partnership for Improved Residential Construction, Cocoa, FL (United States)

    2016-02-01

    The BAPIRC team and Florida Power and Light (FPL) electric utility pursued a pilot phased energy-efficiency retrofit program in Florida by creating detailed data on the energy and economic performance of two levels of retrofit - simple and deep. For this Phased Deep Retrofit (PDR) project, a total of 56 homes spread across the utility partner's territory in east central Florida, southeast Florida, and southwest Florida were instrumented between August 2012 and January 2013, and received simple pass-through retrofit measures during the period of March 2013 - June 2013. Ten of these homes received a deeper package of retrofits during August 2013 - December 2013.

  14. Preliminary findings of China's detailed fertility survey (the first phase).

    Science.gov (United States)

    1986-10-01

    This article summarizes findings of a fertility sampling survey conducted in April 1985 in the Hebei and Shaanxi provinces and Shanghai, China. Altogether, 13,307 married women of reproductive age were interviewed. The results of the nuptiality section, which surveyed 19,956 women aged 15-49 show that 1) a high marriage rate, a low divorce rate, and a stable marriage relationship exist; 2) during the past 30 years, the number of early marriages has declined remarkably and the median age at marriage has risen; 3) in the past 30 years, the peak age at 1st marriage has risen rapidly for women in Shanghai and Hebei while it has risen relatively slowly for women in Shaanxi; 4) in the past 10 years, the mean age at 1st marriage has increased more than 1 year for Shanghai women, has fluctuated for Shaanxi women, and has decreased for Hebei women; and 5) the total 1st marriage rates were high in the early 1980s, but declined slightly in 1984. Factors which influence nuptiality include 1) education on late marriage, and 2) elimination of arranged marriage. The results of the fertility and infant mortality section show that 1) the number of children ever born has been decreasing year by year, 2) a low proportion of primarily infertile women exists, 3) the parity progressive ratio declined rapidly in Shanghai, but more slowly in Hebei and Shaanxi; 4) infant mortality has declined considerably in the last 25 years, because of improvements in medical and health services; 5) age at 1st birth is increasing; and 6) the magnitude of the rise in median age at 1st birth is smaller than the median age at 1st marriage. During the last 10 years, 1) fertility has declined in both Shaanxi and Hebei; 2) the mean age at childbirth has decreased somewhat; 3) the 1-child policy has won wide response; and 4) among infants born 1980-1983, the mortality rate is 19.3 per 1000 in Shanghai and over 34 per 1000 in both Hebei and Shaanxi. The results of the contraception section show that 1

  15. THE GREEN BANK TELESCOPE H II REGION DISCOVERY SURVEY. IV. HELIUM AND CARBON RECOMBINATION LINES

    Energy Technology Data Exchange (ETDEWEB)

    Wenger, Trey V.; Bania, T. M. [Astronomy Department, 725 Commonwealth Avenue, Boston University, Boston, MA 02215 (United States); Balser, Dana S. [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA, 22903-2475 (United States); Anderson, L. D. [Department of Physics, West Virginia University, Morgantown, WV 26506 (United States)

    2013-02-10

    The Green Bank Telescope H II Region Discovery Survey (GBT HRDS) found hundreds of previously unknown Galactic regions of massive star formation by detecting hydrogen radio recombination line (RRL) emission from candidate H II region targets. Since the HRDS nebulae lie at large distances from the Sun, they are located in previously unprobed zones of the Galactic disk. Here, we derive the properties of helium and carbon RRL emission from HRDS nebulae. Our target sample is the subset of the HRDS that has visible helium or carbon RRLs. This criterion gives a total of 84 velocity components (14% of the HRDS) with helium emission and 52 (9%) with carbon emission. For our highest quality sources, the average {sup 4}He{sup +}/H{sup +} abundance ratio by number, (y {sup +}), is 0.068 {+-} 0.023(1{sigma}). This is the same ratio as that measured for the sample of previously known Galactic H II regions. Nebulae without detected helium emission give robust y {sup +} upper limits. There are 5 RRL emission components with y {sup +} less than 0.04 and another 12 with upper limits below this value. These H II regions must have either a very low {sup 4}He abundance or contain a significant amount of neutral helium. The HRDS has 20 nebulae with carbon RRL emission but no helium emission at its sensitivity level. There is no correlation between the carbon RRL parameters and the 8 {mu}m mid-infrared morphology of these nebulae.

  16. Uncertainties of the KIKO3D-ATHLET calculations using the Kalinin-3 benchmark (Phase II) data

    Energy Technology Data Exchange (ETDEWEB)

    Panka, Istvan; Hegyi, Gyoergy; Maraczy, Csaba; Kereszturi, Andras [Hungarian Academy of Sciences, Centre for Energy Research, Budapest (Hungary). Reactor Analysis Dept.

    2016-09-15

    The best estimate simulation of three-dimensional phenomena in nuclear reactor cores requires the use of coupled neutron physics and thermal-hydraulics calculations. However these analyses should be supplemented by the survey of the corresponding uncertainties. In this paper the uncertainties of the coupled KIKO3D-ATHLET calculations are presented for a VVER-1000 type core using the OECD NEA Kalinin-3 (Phase II) benchmark data, although only the neutronic uncertainties are considered and further simplifications are applied and discussed. Additionally, this study has been performed in the conjunction with the OECD NEA UAM benchmark, as well. In the first part of the paper, the uncertainties of the effective multiplication factor, the assembly-wise radial power distribution, the axial power distribution, the rod worth, etc. are presented at steady-state. After that some uncertainties of the transient calculations are discussed for the considered switch-off of one Main Circulation Pump (MCP) type transient.

  17. A Fire Safety Certification System for Board and Care Operators and Staff. SBIR Phase II: Final Report.

    Science.gov (United States)

    Walker, Bonnie L.

    This report describes Phase II of a project which developed a system for delivering fire safety training to board and care providers who serve adults with developmental disabilities. Phase II focused on developing and pilot testing a "train the trainers" workshop for instructors and field testing the provider's workshop. Evaluation of the 2-day…

  18. 78 FR 12006 - Wireline Competition Bureau Seeks Comment on Connect America Phase II Support for Price Cap Areas...

    Science.gov (United States)

    2013-02-21

    ... Price Cap Areas Outside of the Contiguous United States AGENCY: Federal Communications Commission... develop the record on issues relating to Connect America Phase II support for price cap carriers serving... issues relating to Connect America Phase II support for price cap carriers serving areas outside of the...

  19. 76 FR 3624 - Milford Wind Corridor Phase II, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    Science.gov (United States)

    2011-01-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Milford Wind Corridor Phase II, LLC; Supplemental Notice That Initial Market... supplemental notice in the above-referenced proceeding Milford Wind Corridor Phase II, LLC's application for...

  20. The Rise and Fall of Type Ia Supernova Light Curves in the SDSS-II Supernova Survey

    Energy Technology Data Exchange (ETDEWEB)

    Hayden, Brian T.; /Notre Dame U.; Garnavich, Peter M.; /Notre Dame U.; Kessler, Richard; /KICP, Chicago /Chicago U., EFI; Frieman, Joshua A.; /KICP, Chicago /Chicago U. /Fermilab; Jha, Saurabh W.; /Stanford U., Phys. Dept. /Rutgers U., Piscataway; Bassett, Bruce; /Cape Town U., Dept. Math. /South African Astron. Observ.; Cinabro, David; /Wayne State U.; Dilday, Benjamin; /Rutgers U., Piscataway; Kasen, Daniel; /UC, Santa Cruz; Marriner, John; /Fermilab; Nichol, Robert C.; /Portsmouth U., ICG /Baltimore, Space Telescope Sci. /Johns Hopkins U.

    2010-01-01

    We analyze the rise and fall times of Type Ia supernova (SN Ia) light curves discovered by the Sloan Digital Sky Survey-II (SDSS-II) Supernova Survey. From a set of 391 light curves k-corrected to the rest-frame B and V bands, we find a smaller dispersion in the rising portion of the light curve compared to the decline. This is in qualitative agreement with computer models which predict that variations in radioactive nickel yield have less impact on the rise than on the spread of the decline rates. The differences we find in the rise and fall properties suggest that a single 'stretch' correction to the light curve phase does not properly model the range of SN Ia light curve shapes. We select a subset of 105 light curves well observed in both rise and fall portions of the light curves and develop a '2-stretch' fit algorithm which estimates the rise and fall times independently. We find the average time from explosion to B-band peak brightness is 17.38 {+-} 0.17 days, but with a spread of rise times which range from 13 days to 23 days. Our average rise time is shorter than the 19.5 days found in previous studies; this reflects both the different light curve template used and the application of the 2-stretch algorithm. The SDSS-II supernova set and the local SNe Ia with well-observed early light curves show no significant differences in their average rise-time properties. We find that slow-declining events tend to have fast rise times, but that the distribution of rise minus fall time is broad and single peaked. This distribution is in contrast to the bimodality in this parameter that was first suggested by Strovink (2007) from an analysis of a small set of local SNe Ia. We divide the SDSS-II sample in half based on the rise minus fall value, t{sub r} - t{sub f} {approx}< 2 days and t{sub r} - t{sub f} > 2 days, to search for differences in their host galaxy properties and Hubble residuals; we find no difference in host galaxy properties or Hubble

  1. Functional design criteria for Project W-252, Phase II Liquid Effluent Treatment and Disposal: Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Hatch, C.E.

    1994-11-10

    This document provides the functional design criteria required for the Phase 2 Liquid Effluent Treatment and Disposal Project, Project W-252. Project W-252 shall provide new facilities and existing facility modifications required to implement Best Available Technology/All Known, Available, and Reasonable Methods of Prevention, Control, and Treatment (BAT/AKART) for the 200 East Phase II Liquid Effluent Streams. The project will also provide a 200 East Area Phase II Effluent Collection System (PTECS) for connection to a disposal system for relevant effluent streams to which BAT/AKART has been applied. Liquid wastestreams generated in the 200 East Area are currently discharged to the soil column. Included in these wastestreams are cooling water, steam condensate, raw water, and sanitary wastewaters. It is the policy of the DOE that the use of soil columns to treat and retain radionuclides and nonradioactive contaminants be discontinued at the earliest practical time in favor of wastewater treatment and waste minimization. In 1989, the DOE entered into an interagency agreement with Ecology and EPA. This agreement is referred to as the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement). Project W-252 is one of the projects required to achieve the milestones set forth in the Tri-Party Agreement. One of the milestones requires BAT/AKART implementation for Phase II streams by October 1997. This Functional Design Criteria (FDC) document provides the technical baseline required to initiate Project W-252 to meet the Tri-Party Agreement milestone for the application of BAT/AKART to the Phase II effluents.

  2. Equilibrium and kinetic modelling of cadmium (II) biosorption by Dried Biomass Aphanothece sp. from aqueous phase

    Science.gov (United States)

    Awalina; Harimawan, A.; Haryani, G. S.; Setiadi, T.

    2017-05-01

    The Biosorption of cadmium (II) ions on dried biomass of Aphanothece sp.which previously grown in a photobioreactor system with atmospheric carbon dioxide fed input, was studied in a batch system with respect to initial pH, biomass concentration, contact time, and temperature. The biomass exhibited the highest cadmium (II) uptake capacity at 30ºC, initial pH of 8.0±0.2 in 60 minute and initial cadmium (II) ion concentration of 7.76 mg/L. Maximum biosorption capacities were 16.47 mg/g, 54.95 mg/g and 119.05 mg/g at range of initial cadmium (II) 0.96-3.63 mg/L, 1.99-8.10 mg/L and 6.48-54.38 mg/L, respectively. Uptake kinetics follows the pseudo-second order model while equilibrium is best described by Langmuir isotherm model. Isotherms have been used to determine thermodynamic parameter process (free energy change, enthalpy change and entropy change). FTIR analysis of microalgae biomass revealed the presence of amino acids, carboxyl, hydroxyl, sulfhydryl and carbonyl groups, which are responsible for biosorption of metal ions. During repeated sorption/desorption cycles, the ratio of Cd (II) desorption to biosorption decreased from 81% (at first cycle) to only 27% (at the third cycle). Nevertheless, due to its higher biosorption capability than other adsorbent, Aphanothece sp appears to be a good biosorbent for removing metal Cd (II) ions from aqueous phase.

  3. Phase effects in guided mode resonances II: measuring the angular phase of a surface plasmon polariton

    Science.gov (United States)

    Theisen, M. J.; Brown, T. G.

    2015-02-01

    We show how the phase of a resonant interaction between a focused beam and a guided mode can be directly observed in a pupil imaging experiment, in which the irradiance leaving the pupil of a standard microscope is relayed to an image sensor through a combination Wollaston prism, calcite beam splitter and polarizer. We apply the method to the observation of a surface plasmon polariton resonance excited in a corrugated silver film fabricated using electron beam lithography. We discuss how this particular imaging configuration could be adapted for applications in plasmonic optical sensing.

  4. Results of FY 2001 feasibility studies on commercialized fast reactor cycle system phase-II

    Energy Technology Data Exchange (ETDEWEB)

    Noda, Hiroshi; Yamashita, Hidetoshi; Maeda, Fumio; Sato, Kazujiro; Ieda, Yoshiaki; Funasaka, Hideyuki [Japan Nuclear Cycle Development Inst., Tokai, Ibaraki (Japan)

    2002-09-01

    Feasibility Studies on Commercialized Fast Reactor (FR) Cycle System Phase-II were commenced on April 1, 2001, in order to select a few promising candidate concepts for commercialization from the candidate concepts of the FR system and fuel cycle system which were screened in Phase-I, and to present an outline plan for Phase-III onward. In FY 2001, which was the first year of Phase-II, the results of Phase-I and the plan for Phase-II were evaluated as appropriate by The R and D Project Evaluation Committee. With regard to the sodium-cooled medium-scale modular reactor and lead-bismuth cooled modular reactor, economical targets are expected to be achieved. In terms of the gas-cooled reactor, the helium gas-cooled reactor (coated particle fuel type and dispersion fuel type) was screened as a candidate concept. For the reprocessing system, a feasibility of the process for the crystallization method on the advanced aqueous method was confirmed. With regard to the oxide electrowinning method, the technological feasibility of MOX electrowinning co-precipitation was confirmed. In terms of the metal electrowinning method, the possibility of system rationalization was confirmed by Pu recovery testing at liquid Cd cathode. For the fuel fabrication system, in terms of the pelletizing method, the ease of remote-controlled fabrication of low-decontamination TRU fuels was confirmed, and in terms of the vibration compaction method, the packing density is expected to be satisfied as regards the design requirement. With regard to the casting method, the operation parameters of the injection casting technology, which were satisfied to slug specification requirements, were grasped by engineering-scale testing. (author)

  5. Alchemical poetry in medieval and early modern Europe: a preliminary survey and synthesis. Part II - Synthesis.

    Science.gov (United States)

    Kahn, Didier

    2011-03-01

    This article provides a preliminary description of medieval and early modern alchemical poetry composed in Latin and in the principal vernacular languages of western Europe. It aims to distinguish the various genres in which this poetry flourished, and to identify the most representative aspects of each cultural epoch by considering the medieval and early modern periods in turn. Such a distinction (always somewhat artificial) between two broad historical periods may be justified by the appearance of new cultural phenomena that profoundly modified the character of early modern alchemical poetry: the ever-increasing importance of the prisca theologia, the alchemical interpretation of ancient mythology, and the rise of neo-Latin humanist poetry. Although early modern alchemy was marked by the appearance of new doctrines (notably the alchemical spiritus mundi and Paracelsianism), alchemical poetry was only superficially modified by criteria of a scientific nature, which therefore appear to be of lesser importance. This study falls into two parts. Part I provides a descriptive survey of extant poetry, and in Part II the results of the survey are analysed in order to highlight such distinctive features as the function of alchemical poetry, the influence of the book market on its evolution, its doctrinal content, and the question of whether any theory of alchemical poetry ever emerged. Part II is accompanied by an index of the authors and works cited in both parts.

  6. VizieR Online Data Catalog: Second epoch VLBA Calibrator Survey (VCS-II) (Gordon+, 2016)

    Science.gov (United States)

    Gordon, D.; Jacobs, C.; Beasley, A.; Peck, A.; Gaume, R.; Charlot, P.; Fey, A.; Ma, C.; Titov, O.; Boboltz, D.

    2016-07-01

    Six Very Long Baseline Array (VLBA) calibrator survey campaigns were run between 1994 and 2007 (VCS1, Beasley et al. 2002, cat. J/ApJS/141/13; VCS2, Fomalont et al. 2003, cat. J/AJ/126/2562; VCS3, Petrov et al. 2005, cat. J/AJ/129/1163; VCS4, Petrov et al. 2006, cat. J/AJ/131/1872; VCS5, Kovalev et al. 2007, cat. J/AJ/133/1236; VCS6, Petrov et al. 2008, cat. J/AJ/136/580) We report on the results of a second epoch VLBA Calibrator Survey campaign (VCS-II) in which 2400 VCS sources were re-observed in the X and S bands. The VLBA S/X (S band~2.3GHz and X band~8.6GHz) dual frequency system was used. We used the VLBA RDBE/Mark5C system, which has 16 32MHz channels and records 2 Gbits/s using 2 bit sampling. Due to S-band filters below 2200MHz and above 2400MHz at most of the VLBA antennas, and a broad area of RFI from SiriusXM satellites (2320-2345MHz), only four channels could be deployed in the S band (2220.0, 2252.0, 2284.0, and 2348.0MHz). The other 12 channels were deployed in the X band (8460.0, 8492.0, 8524.0, 8556.0, 8620.0, 8652.0, 8716.0, 8748.0, 8812.0, 8844.0, 8876.0, and 8908.0MHz). We set a target of 300 sources per session, or 2400 total sources for the 8 VLBA sessions. We selected all sources from the Goddard Space Flight Center (GSFC) S/X astrometric/geodetic catalog (available at http://gemini.gsfc.nasa.gov/solutions/ or by following the links at http://lupus.gsfc.nasa.gov/) between -50° and +90° decl. that had been observed in only 1 or 2 sessions as of mid 2013. This amounted to ~2060 sources. To fill out the list, we added ~340 additional sources that had been observed but not detected in the original VCS1-6 analysis. The eight schedules were run between 2014 January and 2015 March (VCS-II-A/BG219A on 2014 01/04 10:04-01/05 10:02; VCS-II-B/BG219B1 on 2014 05/31 17:12-06/01 17:05; VCS-II-D/BG219D on 2014 06/09 09:13-06/10 09:10; VCS-II-C/BG219C on 2014 08/05 13:03-08/06 13:00; VCS-II-E/BG219E on 2014 08/09 00:00-08/09 23:55; VCS-II-F/BG219F on 2014

  7. The first preparative solution phase synthesis of melanotan II

    Directory of Open Access Journals (Sweden)

    2008-10-01

    Full Text Available Melanotan II is a synthetic cyclic heptapeptide used to prevent a sunlight-induced skin cancer by stimulating the skin tanning process. In this paper we report the first solution phase synthesis of the title compound. The hexapeptide sequence has been assembled by [(2+2+1+1] scheme. After removing the orthogonal protection, a carbodiimide mediated lactamization, involving the ε-amino group of lysine and γ-carboxy group of aspartic acid, led to a cyclic intermediate. Appending N-acetylnorleucine concluded the assembly of melanotan II molecule. Protection of the lateral groups in arginine and tryptophan was omitted for atom and step economy reasons. The total synthesis of melanotan II was accomplished in 12 steps with 2.6% overall yield, affording >90% pure peptide without using preparative chromatography.

  8. ENGINEERING DEVELOPMENT OF COAL-FIRED HIGH PERFORMANCE POWER SYSTEMS PHASE II AND III

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-30

    This report presents work carried out under contract DE-AC22-95PC95144 "Engineering Development of Coal-Fired High Performance Systems Phase II and III." The goals of the program are to develop a coal-fired high performance power generation system (HIPPS) that is capable of: à thermal efficiency (HHV) >47%; à NOx, SOx, and particulates <10% NSPS (New Source Performance Standard); à coal providing >65% of heat input; à all solid wastes benign; à cost of electricity <90% of present plants. Phase I, which began in 1992, focused on the analysis of various configurations of indirectly fired cycles and on technical assessments of alternative plant subsystems and components, including performance requirements, developmental status, design options, complexity and reliability, and capital and operating costs. Phase I also included preliminary R&D and the preparation of designs for HIPPS commercial plants approximately 300 MWe in size. This phase, Phase II, involves the development and testing of plant subsystems, refinement and updating of the HIPPS commercial plant design, and the site selection and engineering design of a HIPPS prototype plant. Work reported herein is from: à Task 2.2 HITAF Air Heaters; à Task 6 HIPPS Commercial Plant Design Update.

  9. Rigid Polyurethane Foam (RPF) Technology for Countermines (Sea) Program Phase II

    Energy Technology Data Exchange (ETDEWEB)

    WOODFIN,RONALD L.; FAUCETT,DAVID L.; HANCE,BRADLEY G.; LATHAM,AMY E.; SCHMIDT,C.O.

    1999-10-01

    This Phase II report documents the results of one subtask initiated under the joint Department of Energy (DOE)/Department of Defense (DoD) Memorandum of Understanding (MOU) for Countermine Warfare. The development of Rigid Polyurethane Foams for neutralization of mines and barriers in amphibious assault was the objective of the tasking. This phase of the program concentrated on formation of RPF in water, explosive mine simulations, and development of foam and fabric pontoons. Field experimentation was done primarily at the Energetic Materials Research and Testing Center (EMRTC) of the New Mexico Institute of Mining and Technology, Socorro, NM between February 1996 and September 1998.

  10. An FPGA-based trigger for the phase II of the MEG experiment

    Science.gov (United States)

    Baldini, A.; Bemporad, C.; Cei, F.; Galli, L.; Grassi, M.; Morsani, F.; Nicolò, D.; Ritt, S.; Venturini, M.

    2016-07-01

    For the phase II of MEG, we are going to develop a combined trigger and DAQ system. Here we focus on the former side, which operates an on-line reconstruction of detector signals and event selection within 450 μs from event occurrence. Trigger concentrator boards (TCB) are under development to gather data from different crates, each connected to a set of detector channels, to accomplish higher-level algorithms to issue a trigger in the case of a candidate signal event. We describe the major features of the new system, in comparison with phase I, as well as its performances in terms of selection efficiency and background rejection.

  11. Free-Piston Stirling Power Conversion Unit for Fission Power System, Phase II Final Report

    Science.gov (United States)

    Wood, J. Gary; Stanley, John

    2016-01-01

    In Phase II, the manufacture and testing of two 6-kW(sub e)Stirling engines was completed. The engines were delivered in an opposed 12-kW(sub e) arrangement with a common expansion space heater head. As described in the Phase I report, the engines were designed to be sealed both hermetically and with a bolted O-ring seal. The completed Phase II convertor is in the bolted configuration to allow future disassembly. By the end of Phase II, the convertor had passed all of the final testing requirements in preparation for delivery to the NASA Glenn Research Center. The electronic controller also was fabricated and tested during Phase II. The controller sets both piston amplitudes and maintains the phasing between them. It also sets the operating frequency of the machine. Details of the controller are described in the Phase I final report. Fabrication of the direct-current to direct-current (DC-DC) output stage, which would have stepped down the main controller output voltage from 700 to 120 V(sub DC), was omitted from this phase of the project for budgetary reasons. However, the main controller was successfully built, tested with the engines, and delivered. We experienced very few development issues with this high-power controller. The project extended significantly longer than originally planned because of yearly funding delays. The team also experienced several hardware difficulties along the development path. Most of these were related to the different thermal expansions of adjacent parts constructed of different materials. This issue was made worse by the large size of the machine. Thermal expansion problems also caused difficulties in the brazing of the opposed stainless steel sodium-potassium (NaK) heater head. Despite repeated attempts Sunpower was not able to successfully braze the opposed head under this project. Near the end of the project, Glenn fabricated an opposed Inconel NaK head, which was installed prior to delivery for testing at Glenn. Engine

  12. Photoinduced phase transition of the tetrafluoroborate salt of bis( N, N-diethylethylenediamine)copper(II)

    Science.gov (United States)

    Naumov, Panče; Sakurai, Kenji

    2006-08-01

    The continuous temperature-induced change of the ligand field strain in a pseudo-Jahn-Teller thermochromic crystal bis( N, N-diethylethylenediamine)copper(II) tetrafluoroborate was studied. In situ powder photodiffraction was employed to demonstrate that at the low-temperature limit of the gradual lattice stability another structural phase transition can be triggered by photoinduction of the intramolecular ligand-to-metal charge transfer. The minute differences in the cationic structure imposed by the isomorphic ionic substitution result in increase of the temperature of the photoinduced phase transition of about 30 K relative to the perchlorate salt.

  13. Performance of the Tile PreProcessor Demonstrator for the ATLAS Tile Calorimeter Phase II Upgrade

    CERN Document Server

    Carrio Argos, Fernando; The ATLAS collaboration

    2015-01-01

    The Tile Calorimeter PreProcessor (TilePPr) demonstrator is a high performance double AMC board based on FPGA resources and QSFP modules. This board has been designed in the framework of the ATLAS Tile Calorimeter (TileCal) Demonstrator Project for the Phase II Upgrade as the first stage of the back-end electronics. The TilePPr demonstrator has been conceived for receiving and processing the data coming from the front-end electronics of the TileCal Demonstrator module, as well as for configuring it. Moreover, the TilePPr demonstrator handles the communication with the Detector Control System to monitor and control the front-end electronics. The TilePPr demonstrator represents 1/8 of the final TilePPr that will be designed and installed into the detector for the ATLAS Phase II Upgrade.

  14. Microscopic model for the neutron dynamic structure factor of solid methane in phase II

    Energy Technology Data Exchange (ETDEWEB)

    Shin Yunchang, E-mail: yunchang.shin@yale.ed [Department of Physics, Indiana University Bloomington, IN 47408 (United States); Department of Physics, Yale University, New Haven, CT 06520 (United States); Mike Snow, W.; Liu, C.Y.; Lavelle, C.M.; Baxter, David V. [Department of Physics, Indiana University Bloomington, IN 47408 (United States)

    2010-08-21

    We have constructed a microscopic model for the neutron dynamic structure factor S(Q,{omega}) of solid methane in phase II. We expect this model to apply for neutron energies below 1 eV at pressures near 1 bar and temperatures below 20 K where methane possesses both free rotation and hindered rotation modes of the tetrahedral molecules in the unit cell. The model treats the motions of molecular translations, intra-molecular vibrations and the free and hindered rotations of methane molecule as independent. Total scattering cross-sections calculated from the model agree with the cross-section measurements for incident neutron energies of 0.5 meV-1 eV. The effective density of states is extracted from the model. We also present the quantitative calculation of the separate contributions of the two different rotational modes to the inelastic cross-section for different methane temperatures in phase II.

  15. COSMOLOGY WITH PHOTOMETRICALLY CLASSIFIED TYPE Ia SUPERNOVAE FROM THE SDSS-II SUPERNOVA SURVEY

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, Heather; D' Andrea, Chris B; Nichol, Robert C.; Smith, Mathew; Lampeitl, Hubert [Institute of Cosmology and Gravitation, University of Portsmouth, Portsmouth, PO1 3FX (United Kingdom); Sako, Masao [Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104 (United States); Olmstead, Matthew D.; Brown, Peter; Dawson, Kyle S. [Department of Physics and Astronomy, University of Utah, 115 South 1400 East 201, Salt Lake City, UT 84112 (United States); Bassett, Bruce [Mathematics Department, University of Cape Town, Rondebosch, Cape Town (South Africa); Biswas, Rahul; Kuhlmann, Steve [Argonne National Laboratory, 9700 South Cass Avenue, Lemont, IL 60439 (United States); Cinabro, David [Department of Physics and Astronomy, Wayne State University, Detroit, MI 48126 (United States); Dilday, Ben [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Dr., Suite 102, Goleta, CA 93117 (United States); Foley, Ryan J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Frieman, Joshua A. [Department of Astronomy and Astrophysics, The University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637 (United States); Garnavich, Peter [Department of Physics, University of Notre Dame, Notre Dame, IN 46556 (United States); Hlozek, Renee [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Jha, Saurabh W. [Department of Physics and Astronomy, Rutgers University, 136 Frelinghuysen Road, Piscataway, NJ 08854 (United States); Kunz, Martin, E-mail: Heather.Campbell@port.ac.uk [African Institute for Mathematical Sciences, Muizenberg, 7945, Cape Town (South Africa); and others

    2013-02-15

    We present the cosmological analysis of 752 photometrically classified Type Ia Supernovae (SNe Ia) obtained from the full Sloan Digital Sky Survey II (SDSS-II) Supernova (SN) Survey, supplemented with host-galaxy spectroscopy from the SDSS-III Baryon Oscillation Spectroscopic Survey. Our photometric-classification method is based on the SN classification technique of Sako et al., aided by host-galaxy redshifts (0.05 < z < 0.55). SuperNova ANAlysis simulations of our methodology estimate that we have an SN Ia classification efficiency of 70.8%, with only 3.9% contamination from core-collapse (non-Ia) SNe. We demonstrate that this level of contamination has no effect on our cosmological constraints. We quantify and correct for our selection effects (e.g., Malmquist bias) using simulations. When fitting to a flat {Lambda}CDM cosmological model, we find that our photometric sample alone gives {Omega} {sub m} = 0.24{sup +0.07} {sub -0.05} (statistical errors only). If we relax the constraint on flatness, then our sample provides competitive joint statistical constraints on {Omega} {sub m} and {Omega}{sub {Lambda}}, comparable to those derived from the spectroscopically confirmed Three-year Supernova Legacy Survey (SNLS3). Using only our data, the statistics-only result favors an accelerating universe at 99.96% confidence. Assuming a constant wCDM cosmological model, and combining with H {sub 0}, cosmic microwave background, and luminous red galaxy data, we obtain w = -0.96{sup +0.10} {sub -0.10}, {Omega} {sub m} = 0.29{sup +0.02} {sub -0.02}, and {Omega} {sub k} = 0.00{sup +0.03} {sub -0.02} (statistical errors only), which is competitive with similar spectroscopically confirmed SNe Ia analyses. Overall this comparison is reassuring, considering the lower redshift leverage of the SDSS-II SN sample (z < 0.55) and the lack of spectroscopic confirmation used herein. These results demonstrate the potential of photometrically classified SN Ia samples in improving

  16. The Green Bank Telescope H II Region Discovery Survey: IV. Helium and Carbon Recombination Lines

    CERN Document Server

    Wenger, Trey V; Balser, Dana S; Anderson, L D

    2012-01-01

    The Green Bank Telescope H II Region Discovery Survey (GBT HRDS) found hundreds of previously unknown Galactic regions of massive star formation by detecting hydrogen radio recombination line (RRL) emission from candidate H II region targets. Since the HRDS nebulae lie at large distances from the Sun, they are located in previously unprobed zones of the Galactic disk. Here we derive the properties of helium and carbon RRL emission from HRDS nebulae. Our target sample is the subset of the HRDS that has visible helium or carbon RRLs. This criterion gives a total of 84 velocity components (14% of the HRDS) with helium emission and 52 (9%) with carbon emission. For our highest quality sources, the average ionic He-4+/H+ abundance ratio by number, , is 0.068 +/- 0.023 (1-sigma). This is the same ratio as that measured for the sample of previously known Galactic H II regions. Nebulae without detected helium emission give robust y+ upper limits. There are 5 RRL emission components with y+ less than 0.04 and another ...

  17. Global Air Mobility Advanced Technologies (GAMAT) Advanced Technology Development (ATD) Phase II Research and Development

    Science.gov (United States)

    2004-05-01

    chapter will begin with an overview of the focal topics we selected for design intervention generally, and then proceed to a discussion of how we...chapter will begin with an overview of the focal topics we selected for design intervention , then proceed to a discussion of the specific design concepts...GAMAT KA work and (b) judged relevant to our Phase II focus on flight planning. Some of these items are indicative of problems for which WCSS design

  18. Phase I-II study of isotopic immunoglobulin therapy for primary liver cancer

    Energy Technology Data Exchange (ETDEWEB)

    Ettinger, D.S.; Order, S.E.; Wharam, M.D.; Parker, M.K.; Klein, J.L.; Leichner, P.K.

    1982-02-01

    A phase I-II study of isotopic immunoglobulin therapy was performed in 18 patients with primary liver cancer; 14 were evaluable for toxicity. The patients received a dose of 37-157 millicuries of 131I-labeled antibody. The dose-limiting factor appears to be hematologic toxicity, especially thrombocytopenia. An objective antitumor effect was seen in six of nine patients who were evaluable for response. Present results suggest that further clinical studies with isotopic immunoglobulin are indicated.

  19. Phase II NOx controls for the Marama and Nescaum regions. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-11-01

    This technical report discusses Phase II NOx controls for utility boilers in the Mid-Atlantic Regional Air Management Association (MARAMA) and the Northeast States for Coordinated Air Use Management (NESCAUM) regions. The subject areas include: Utility boiler population profile in the MARAMA and NESCAUM regions; Discussion of RACT controls; Available NOx controls and their levels of performance; and Costs and cost effectiveness of NOx controls.

  20. Phase II study of bevacizumab and temsirolimus combination therapy for recurrent glioblastoma multiforme

    DEFF Research Database (Denmark)

    Lassen, Ulrik; Sorensen, Morten; Gaziel, Tine Bernhardtsen

    2013-01-01

    Bevacizumab combined with chemotherapy has recently shown promising efficacy in recurrent high-grade glioma. Phosphatase and tensin homolog (PTEN) mutation in glioblastoma multiforme (GBM) patients causes abnormally high activity of the pathways of Phosphatidylinositide 3-kinases (PI3K), Protein...... been investigated, but with the hypothesis that temsirolimus might provide complimentary therapeutic benefit in combination with bevacizumab, we included patients with progressive GBM after bevacizumab in an open phase II study....

  1. Flexible roof drill for low coal. Volume 1. Phase I and Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Shoup, N.H.; Kendall, L.A.

    1977-08-30

    The Phase I report documents the effort expended by the Washington State University (WSU) research team towards meeting the terms of the contract and provides a working document for the research team during the later phases of this research project. The flexible shaft drill concepts for thin seam coal were based upon operational specifications prepared by the WSU research team after consultation with the Coal Mine Productivity Task Force of the US Steel Corporation. Investigations disclosed that a flexible shaft drill should be designed to withstand a torque load of 3000 in.-lb, a thrust load of 6000 lb, a mean feed rate of 3 ft/min (feed rate range should be 1 to 6 ft/min), withdrawal rate of 40 ft/min, and have the ability to drill an 8-ft deep hole within +- 10/sup 0/ of the vertical centerline. In order to maintain this alignment, a straight starter section would be used at the drill bit end of the drill. The length of this starter section varies with hole tolerance; based on drill hole measurements in soft, semi-consolidated shale a minimum starter section length of about 9 in. was chosen. After considering a number of alternative types of flexible shafts, it was concluded that the flexible shaft should be made up of short rigid segments interlocked at their interfaces with intermeshed teeth. Three interlocking clutch teeth at the interface were selected because to increasing the number of clutch teeth would increase the stress in each tooth to a prohibitively high level. Segments should have some restraining devices at the connecting interfaces preventing the segments from separating. This interfacial restraint should allow the segments to transmit tension loads across the interface. This is desirable so that the drill string can be withdrawn from the hole by applying tensile force to the segments.

  2. Flexible designs for phase II comparative clinical trials involving two response variables.

    Science.gov (United States)

    Bersimis, S; Sachlas, A; Papaioannou, T

    2015-01-30

    The aim of phase II clinical trials is to determine whether an experimental treatment is sufficiently promising and safe to justify further testing. The need for reduced sample size arises naturally in phase II clinical trials owing to both technical and ethical reasons, motivating a significant part of research in the field during recent years, while another significant part of the research effort is aimed at more complex therapeutic schemes that demand the consideration of multiple endpoints to make decisions. In this paper, our attention is restricted to phase II clinical trials in which two treatments are compared with respect to two dependent dichotomous responses proposing some flexible designs. These designs permit the researcher to terminate the clinical trial when high rates of favorable or unfavorable outcomes are observed early enough requiring in this way a small number of patients. From the mathematical point of view, the proposed designs are defined on bivariate sequences of multi-state trials, and the corresponding stopping rules are based on various distributions related to the waiting time until a certain number of events appear in these sequences. The exact distributions of interest, under a unified framework, are studied using the Markov chain embedding technique, which appears to be very useful in clinical trials for the sample size determination. Tables of expected sample size and power are presented. The numerical illustration showed a very good performance for these new designs.

  3. Evaluation of Beam Losses and Energy Depositions for a Possible Phase II Design for LHC Collimation

    CERN Document Server

    Lari, L; Bracco, C; Brugger, M; Cerutti, F; Doyle, E; Ferrari, A; Keller, L; Lundgren, S; Keller, L; Mauri, M; Redaelli, S; Sarchiapone, L; Smith, J; Vlachoudis, V; Weiler, T

    2008-01-01

    The LHC beams are designed to have high stability and to be stored for many hours. The nominal beam intensity lifetime is expected to be of the order of 20h. The Phase II collimation system has to be able to handle particle losses in stable physics conditions at 7 TeV in order to avoid beam aborts and to allow correction of parameters and restoration to nominal conditions. Monte Carlo simulations are needed in order to evaluate the behavior of metallic high-Z collimators during operation scenarios using a realistic distribution of losses, which is a mix of the three limiting halo cases. Moreover, the consequences in the IR7 insertion of the worst (case) abnormal beam loss are evaluated. The case refers to a spontaneous trigger of the horizontal extraction kicker at top energy, when Phase II collimators are used. These studies are an important input for engineering design of the collimation Phase II system and for the evaluation of their effect on adjacent components. The goal is to build collimators that can ...

  4. The VMC Survey. XIII. Type II Cepheids in the Large Magellanic Cloud

    CERN Document Server

    Ripepi, V; Marconi, M; Clementini, G; Cioni, M-R L; de Grijs, R; Emerson, J P; Groenewegen, M A T; Ivanov, V D; Muraveva, T; Piatti, A E; Subramanian, S

    2014-01-01

    The VISTA survey of the Magellanic Clouds System (VMC) is collecting deep $K_\\mathrm{s}$--band time--series photometry of the pulsating variable stars hosted in the system formed by the two Magellanic Clouds and the Bridge connecting them. In this paper we have analysed a sample of 130 Large Magellanic Cloud (LMC) Type II Cepheids (T2CEPs) found in tiles with complete or near complete VMC observations for which identification and optical magnitudes were obtained from the OGLE III survey. We present $J$ and $K_\\mathrm{s}$ light curves for all 130 pulsators, including 41 BL Her, 62 W Vir (12 pW Vir) and 27 RV Tau variables. We complement our near-infrared photometry with the $V$ magnitudes from the OGLE III survey, allowing us to build a variety of Period-Luminosity ($PL$), Period-Luminosity-Colour ($PLC$) and Period-Wesenheit ($PW$) relationships, including any combination of the $V, J, K_\\mathrm{s}$ filters and valid for BL Her and W Vir classes. These relationships were calibrated in terms of the LMC distanc...

  5. MASH-II: More Planetary Nebulae from the AAO/UKST H\\alpha Survey

    CERN Document Server

    Miszalski, B; Acker, A; Birkby, J L; Frew, D J; Kovacevic, A

    2007-01-01

    We present a supplement to the Macquarie/AAO/Strasbourg H$\\alpha$ planetary nebulae (PNe) catalogue (MASH), which we denote MASH-II. The supplement consists of over 300 true, likely and possible new Galactic PNe found after re-examination of the entire AAO/UKST H$\\alpha$ survey of the southern Galactic Plane in digital form. We have spectroscopically confirmed over 240 of these new candidates as bona-fide PNe and we include other high quality candidates awaiting spectroscopic confirmation as possible PNe. These latest discoveries largely comprise two distinct groups: small, star-like or moderately resolved PNe at one end and mostly large, extremely low surface brightness PNe at the other. Neither group were easy to discover from simple visual scrutiny of the original survey exposures as for MASH but were relatively straightforward to uncover from the digital images via application of semi-automated discovery techniques. We suspect the few PNe still hidden in the H$\\alpha$ survey will lie outside our search cr...

  6. Loetschberg low-level tunnel: thermal use of tunnel water at the south portal - Feasibility study, phase II; Waermenutzung Tunnelwasser Basistunnel Loetschberg, Suedportal. Machbarkeitsstudie Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Dups, Ch.

    2004-07-01

    This report for the Swiss Federal Office of Energy (SFOE) discusses the results obtained from phase II of a feasibility study on the thermal use of drainage water from the Loetschberg basis railway tunnel under the Swiss Alps. The potential for the use of the drainage water is discussed and the possible use of the heat in the industrial estates in Raron and Niedergesteln is looked at. The report recommends the further investigation of the use of the water as a source of heat for heat-pumps and its treatment for further use as drinking water. Other possible uses examined include the heating of greenhouses, in fish farms, as a water supply for a gravel and concrete works and for keeping local roads and motorways frost-free.

  7. Validation of the THIRST steam generator thermalhydraulic code against the CLOTAIRE phase II experimental data

    Energy Technology Data Exchange (ETDEWEB)

    Pietralik, J.M.; Campagna, A.O.; Frisina, V.C

    1999-04-01

    Steam generator thermalhydraulic codes are frequently used to calculate both global and local parameters inside a stern generator. The global parameters include heat transfer output, recirculation ratio, outlet temperatures, and pressure drops for operating and abnormal conditions. The local parameters are used in further analyses of flow-induced vibration, fretting wear, sludge deposition, and flow-accelerated corrosion. For these purposes, detailed, 3-dimensional 2-phase flow and heat transfer parameters are needed. To make the predictions more accurate and reliable, the codes need to be validated in geometries representative of real conditions. One such study is an international co-operative experimental program called CLOTAIRE, which is based in France. The CANDU Owners Group(COG) participated in the first two phases of the program. The results of the validation of Phase 1 were presented at the 1994 Steam Generator and Heat Exchanger Conference, and the results of the validation of Phase II are the subject of this report. THIRST is a thermalhydraulic, finite-volume code used to predict flow and heat transfer in steam generators. The local results of CLOTAIRE Phase II were used to validate the code. The results consist of the measurements of void fraction and axial gas-phase velocity in the U-bend region. The measurements were done using bi-optical probes. A comparison of global results indicates that the THIRST predictions, with the Chisholm void fraction model, are within 2% to 3% of the experimental results. Using THIRST with the homogeneous void fraction model, the global results were less accurate but still gave very good predictions; the greatest error was 10% for the separator pressure drop. Comparisons of the local predictions for void fraction and axial gas-phase velocity show good agreement. The Chisholm void fraction model generally gives better agreement with the experimental data, whereas the homogeneous model tends to overpredict the void fraction

  8. Validation of the THIRST steam generator thermalhydraulic code against the CLOTAIRE phase II experimental data

    Energy Technology Data Exchange (ETDEWEB)

    Pietralik, J.M.; Campagna, A.O.; Frisina, V.C. [Atomic Energy of Canada Limited, Chalk River, Ontario (Canada)

    1998-07-01

    Steam generator thermalhydraulic codes are used frequently to calculate both global and local parameters inside the steam generator. The former include heat transfer output, recirculation ratio, outlet temperatures, and pressure drops for operating and abnormal conditions. The latter are used in further analyses of flow-induced vibration, fretting wear, sludge deposition, and flow accelerated corrosion. For these purposes, detailed, three-dimensional two-phase flow and heat transfer parameters are needed. To make the predictions more accurate and reliable, the codes need to be validated in geometries representative of real conditions. One such study is an international cooperative experimental program called CLOTAIRE based in France. COG participated in the first two phases of the program; the results of the validation of Phase 1 were presented at the 1994 Steam Generator and Heat Exchanger Conference, and the results of the validation of Phase II are the subject of this paper. THIRST is a thermalhydraulic, finite volume code to predict the flow and heat transfer in steam generators. The local results of CLOTAIRE Phase II have been used to validate the code. These consist of the measurements of void fraction and axial gas-phase velocity in the U-bend region. The measurements were done using bi-optical probes. A comparison of global results indicates that the THIRST predictions, with the Chisholm void fraction model, are within 2 to 3% of the experimental results. Using THIRST with the homogeneous void fraction model, the global results were less accurate but still well predicted with the greatest error of 10% for the separator pressure drop. Comparisons of the local predictions for void fraction and axial gas-phase show good agreement. The Chisholm void fraction model generally gives better agreement with the experimental data while the homogeneous model tends to overpredict the void fraction and underpredict the gas velocity. (author)

  9. In vivo induction of phase II detoxifying enzymes, glutathione transferase and quinone reductase by citrus triterpenoids

    Directory of Open Access Journals (Sweden)

    Ahmad Hassan

    2010-09-01

    Full Text Available Abstract Background Several cell culture and animal studies demonstrated that citrus bioactive compounds have protective effects against certain types of cancer. Among several classes of citrus bioactive compounds, limonoids were reported to prevent different types of cancer. Furthermore, the structures of citrus limonoids were reported to influence the activity of phase II detoxifying enzymes. The purpose of the study was to evaluate how variations in the structures of citrus limonoids (namely nomilin, deacetyl nomilin, and isoobacunoic acid and a mixture of limonoids would influence phase II enzyme activity in excised tissues from a mouse model. Methods In the current study, defatted sour orange seed powder was extracted with ethyl acetate and subjected to silica gel chromatography. The HPLC, NMR and mass spectra were used to elucidate the purity and structure of compounds. Female A/J mice were treated with three limonoids and a mixture in order to evaluate their effect on phase II enzymes in four different tissues. Assays for glutathione S-transferase and NAD(PH: quinone reductase (QR were used to evaluate induction of phase II enzymatic activity. Results The highest induction of GST against 1-chloro-2,4-dinitrobenzene (CDNB was observed in stomach (whole, 58% by nomilin, followed by 25% isoobacunoic acid and 19% deacetyl nomilin. Deacetyl nomilin in intestine (small as well as liver significantly reduced GST activity against CDNB. Additionally isoobacunoic acid and the limonoid mixture in liver demonstrated a significant reduction of GST activity against CDNB. Nomilin significantly induced GST activity against 4-nitroquinoline 1-oxide (4NQO, intestine (280% and stomach (75% while deacetyl nomilin showed significant induction only in intestine (73%. Induction of GST activity was also observed in intestine (93% and stomach (45% treated with the limonoid mixture. Finally, a significant induction of NAD(PH: quinone reductase (QR activity was

  10. Food Consumption and Handling Survey for Quantitative Microbiological Consumer Phase Risk Assessments.

    Science.gov (United States)

    Chardon, Jurgen; Swart, Arno

    2016-07-01

    In the consumer phase of a typical quantitative microbiological risk assessment (QMRA), mathematical equations identify data gaps. To acquire useful data we designed a food consumption and food handling survey (2,226 respondents) for QMRA applications that is especially aimed at obtaining quantitative data. For a broad spectrum of food products, the survey covered the following topics: processing status at retail, consumer storage, preparation, and consumption. Questions were designed to facilitate distribution fitting. In the statistical analysis, special attention was given to the selection of the most adequate distribution to describe the data. Bootstrap procedures were used to describe uncertainty. The final result was a coherent quantitative consumer phase food survey and parameter estimates for food handling and consumption practices in The Netherlands, including variation over individuals and uncertainty estimates.

  11. Phase II Trial of Angiotensin-(1-7 for the Treatment of Patients with Metastatic Sarcoma

    Directory of Open Access Journals (Sweden)

    Paul D. Savage

    2016-01-01

    Full Text Available Background. Angiotensin-(1-7 [Ang-(1-7] is an endogenous antiangiogenic hormone with anticancer activity. In a phase I study of Ang-(1-7, two of three patients with metastatic sarcoma experienced disease stabilization. This phase II study examined clinical and biomarker outcomes for patients with metastatic sarcoma. Methods. Ang-(1-7 was administered by subcutaneous injection at a dose of 20 mg daily. If excessive toxicities occurred in the first cohort, a dose deescalation cohort was allowed. Blood samples were obtained to measure changes in biomarkers. Results. Treatment was well-tolerated and the dose deescalation cohort was not required. Plasma PlGF concentrations following treatment were not statistically significantly changed. A significant increase in plasma Ang-(1-7 was observed at 4 hours after injection. The median progression-free survival was 2.7 months (95% CI; 1.4 to 4.1 months, and the median overall survival was 10.2 months (95% CI; 5.3 to 18.3 months. Two patients with vascular sarcomas demonstrated prolonged disease stabilization of 10 months (hemangiopericytoma and 19 months (epithelioid hemangioendothelioma. Conclusions. Ang-(1-7 at a dose of 20 mg daily was well-tolerated. This prospective phase II study failed to confirm the PlGF biomarker effect identified in the prior phase I study. Prolonged disease stabilization in hemangiopericytoma and epithelioid hemangioendothelioma may warrant further investigation.

  12. White Dwarf - Red Dwarf Systems Resolved with the Hubble Space Telescope. II. Full Snapshot Survey Results

    CERN Document Server

    Farihi, J; Wachter, S

    2010-01-01

    {Abrigded} Results are presented for a Hubble Space Telescope Advanced Camera for Surveys high-resolution imaging campaign of 90 white dwarfs with known or suspected low mass stellar and substellar companions. Of the 72 targets which remain candidate and confirmed white dwarfs with near-infrared excess, 43 are spatially resolved into two or more components, and a total of 12 systems are potentially triples. There is a possible, slight deficit of earlier spectral types (bluer colors) among the spatially unresolved companions, exactly the opposite of expectations if significant mass is transferred to the companion during the common envelope phase. Using the best available distance estimates, the low mass companions to white dwarfs exhibit a bimodal distribution in projected separation. This result supports the hypothesis that during the giant phases of the white dwarf progenitor, any unevolved companions either migrate inward to short periods of hours to days, or outward to periods of hundreds to thousands of y...

  13. Hepatic phase I and phase II biotransformations in quail and trout: comparison to other species commonly used in toxicity testing.

    Science.gov (United States)

    Gregus, Z; Watkins, J B; Thompson, T N; Harvey, M J; Rozman, K; Klaassen, C D

    1983-03-15

    The ability of quail and trout to perform a number of representative phase I and phase II biotransformations was examined. To facilitate interspecies comparisons, metabolism of the same substrates was examined simultaneously under uniform conditions for rat, mouse, rabbit, guinea pig, cat, and dog. Both nonmammalian species can metabolize four representative substrates of phase I mixed-function oxidases and one substrate of epoxide hydrolase, though activity tended to be lower than that of the mammals. Important differences in the conjugative pathways were also noted. Among these differences were the quail's relative deficiency in glutathione conjugation and the trout's low ability to conjugate sulfate compounds. Trout liver UDP-glucuronosyltransferase activity was remarkably high toward testosterone and bilirubin, while quail liver formed glucuronides of naphthol, p-nitrophenol, and digitoxigenin-monodigitoxoside. Also noteworthy was the high N-acetyltransferase activity of both quail and trout toward isoniazid, beta-naphthylamine, and 2-aminofluorene. Differences in substrate specificity for a given enzymatic pathway may be an indication that multiple forms of drug metabolizing systems also occur in these nonmammalian species. Observation of several hundred- or even thousand-fold differences between species in their enzyme activities for certain substrates under uniform conditions re-emphasizes the need for caution in extrapolation of xenobiotic metabolism from one species to another.

  14. THE COORDINATED RADIO AND INFRARED SURVEY FOR HIGH-MASS STAR FORMATION. II. SOURCE CATALOG

    Energy Technology Data Exchange (ETDEWEB)

    Purcell, C. R.; Hoare, M. G.; Lumsden, S. L.; Urquhart, J. S. [School of Physics and Astronomy, E.C. Stoner Building, University of Leeds, Leeds LS2 9JT (United Kingdom); Cotton, W. D. [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903-2475 (United States); Chandler, C. [National Radio Astronomy Observatory, Array Operations Center, P.O. Box O, 1003 Lopezville Road, Socorro, NM 87801-0387 (United States); Churchwell, E. B. [The University of Wisconsin, Department of Astronomy, 475 North Charter Street, Madison, WI 53706 (United States); Diamond, P.; Fuller, G.; Garrington, S. T. [Jodrell Bank Centre for Astrophysics, The Alan Turing Building, School of Physics and Astronomy, The University of Manchester, Oxford Rd, Manchester, M13 9PL (United Kingdom); Dougherty, S. M. [National Research Council of Canada, Herzberg Institute for Astrophysics, Dominion Radio Astrophysical Observatory, P.O. Box 248, Penticton, British Columbia V2A 6J9 (Canada); Fender, R. P. [School of Physics and Astronomy, University of Southampton, Southampton SO17 1BJ (United Kingdom); Gledhill, T. M. [Science and Technology Research Institute, University of Hertfordshire, College Lane, Hatfield AL10 9AB (United Kingdom); Goldsmith, P. F. [Jet Propulsion Laboratory, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Hindson, L. [CSIRO Astronomy and Space Science, P.O. Box 76, Epping, NSW 1710 (Australia); Jackson, J. M. [Astronomy Department, Boston University, 725 Commonwealth Avenue, Boston, MA 02215 (United States); Kurtz, S. E. [Centro de Radioastronomia y Astrofisica, Universidad Nacional Autonoma de Mexico - Morelia, Apartado Postal 3-72, C.P. 58090 Morelia, Michoacan (Mexico); Marti, J., E-mail: C.R.Purcell@leeds.ac.uk [Departamento de Fisica, EPSJ, Universidad de Jaen, Campus Las Lagunillas s/n, Edif. A3, E-23071 Jaen (Spain); and others

    2013-03-01

    The CORNISH project is the highest resolution radio continuum survey of the Galactic plane to date. It is the 5 GHz radio continuum part of a series of multi-wavelength surveys that focus on the northern GLIMPSE region (10 Degree-Sign < l < 65 Degree-Sign ), observed by the Spitzer satellite in the mid-infrared. Observations with the Very Large Array in B and BnA configurations have yielded a 1.''5 resolution Stokes I map with a root mean square noise level better than 0.4 mJy beam{sup -1}. Here we describe the data-processing methods and data characteristics, and present a new, uniform catalog of compact radio emission. This includes an implementation of automatic deconvolution that provides much more reliable imaging than standard CLEANing. A rigorous investigation of the noise characteristics and reliability of source detection has been carried out. We show that the survey is optimized to detect emission on size scales up to 14'' and for unresolved sources the catalog is more than 90% complete at a flux density of 3.9 mJy. We have detected 3062 sources above a 7{sigma} detection limit and present their ensemble properties. The catalog is highly reliable away from regions containing poorly sampled extended emission, which comprise less than 2% of the survey area. Imaging problems have been mitigated by down-weighting the shortest spacings and potential artifacts flagged via a rigorous manual inspection with reference to the Spitzer infrared data. We present images of the most common source types found: H II regions, planetary nebulae, and radio galaxies. The CORNISH data and catalog are available online at http://cornish.leeds.ac.uk.

  15. On the polymorphism of benzocaine; a low-temperature structural phase transition for form (II).

    Science.gov (United States)

    Chan, Eric J; Rae, A David; Welberry, T Richard

    2009-08-01

    A low-temperature structural phase transition has been observed for form (II) of benzocaine (BZC). Lowering the temperature doubles the b-axis repeat and changes the space group from P2(1)2(1)2(1) to P112(1) with gamma now 99.37 degrees. The structure is twinned, the twin rule corresponding to a 2(1) screw rotation parallel to a. The phase transition is associated with a sequential displacement parallel to a of zigzag bi-layers of ribbons perpendicular to b*. No similar phase transition was observed for form (I) and this was attributed to the different packing symmetries of the two room-temperature polymorphic forms.

  16. Structure and compressibility of the high-pressure molecular phase II of carbon dioxide

    Science.gov (United States)

    Datchi, Frédéric; Mallick, Bidyut; Salamat, Ashkan; Rousse, Gwenaëlle; Ninet, Sandra; Garbarino, Gaston; Bouvier, Pierre; Mezouar, Mohamed

    2014-04-01

    The structure and equation of state of the crystalline molecular phase II of carbon dioxide have been investigated at room temperature from 15.5 to 57.5 GPa using synchrotron x-ray diffraction methods. The CO2 samples were embedded in neon pressure medium in order to provide quasihydrostatic conditions. The x-ray diffraction patterns of phase II are best described by a tetragonal structure, with space group P42/mnm and 2 molecules per unit cell, in accordance with a previous study [Yoo et al., Phys. Rev. B 65, 104103 (2002), 10.1103/PhysRevB.65.104103]. There is however a large (15%) difference in the intramolecular C=O bond length between the present study, 1.14(3) Å, and the latter work (1.329-1.366 Å). The present value is similar to that of the free molecule and is in very good agreement with predictions based on density functional theory. The compressibility of CO2-II determined here also disagrees with the previous study: our value for the zero-pressure bulk modulus, B0=8.5(3) GPa [with B0'=(∂B/∂P)0=6.29], is 15.5 times smaller. These findings oppose the view that CO2-II is an intermediate state between the low-pressure molecular phases and the high-pressure nonmolecular forms, consistent with our previous results for phase IV [Datchi et al., Phys. Rev. Lett. 103, 185701 (2009), 10.1103/PhysRevLett.103.185701]. The x-ray diffraction patterns of CO2-II above 15 GPa indicate the presence of a large orthorhombic microstrain. Carrying out density functional theory calculations of the elastic tensor and stress-strain relation, we interpret this as due to the softness of the crystal against deviatoric stress in the [110] and symmetry-related directions. Unlike the other dioxides of the group-14 elements, there is however no mechanical or dynamical instability of the P42/mnm structure in CO2 up to 57.5 GPa at 295 K, and therefore no symmetry lowering to Pnnm.

  17. Database creation, data quality assessment, and geochemical maps (phase V, deliverable 59)—Final report on compilation and validation of geochemical data: Chapter D in Second projet de renforcement institutionnel du secteur minier de la République Islamique de Mauritanie (PRISM-II)

    Science.gov (United States)

    Eppinger, Robert G.; Giles, Stuart A.; Lee, Gregory K.; Smith, Steven M.

    2015-01-01

    Under the World Bank-funded Second Projet de Renforcement Institutionnel du Secteur Minier de la Republique Islamique de Mauritanie (PRISM-II), this Phase V geochemistry report follows earlier Phase I and Phase II summary reports on geochemical data (U.S. Geological Survey, 2007 and Eppinger, 2007; respectively). All the reports are based on evaluations of geochemical data collected in 1999-2004 under an earlier World Bank program (PRISM-I) by the British Geological Survey (BGS) and the Bureau de Recherches Géologiques et Minières (BRGM) for the Government of Mauritania. There are no associated Phase III or IV reports.

  18. Zinc(II) oxide solubility and phase behavior in aqueous sodium phosphate solutions at elevated temperatures

    Energy Technology Data Exchange (ETDEWEB)

    Ziemniak, S.E.; Jones, M.E.; Combs, K.E.S.

    1990-02-01

    A platinum-lined, flowing autoclave facility is used to investigate the solubility/phase behavior of zinc(II) oxide in aqueous sodium phosphate solutions at temperatures between 290 and 560 K. ZnO solubilities are observed to increase continuously with temperature and phosphate concentration. At higher phosphate concentrations, a solid phase transformation to NaZnPO{sub 4} is observed. NaZnPO{sub 4} solubilities are retrograde with temperature. The measured solubility behavior is examined via a Zn(II) ion hydrolysis/complexing model and thermodynamic functions for the hydrolysis/complexing reaction equilibria are obtained from a least-squares analysis of the data. The existence of two new zinc(II) ion complexes is reported for the first time: Zn(OH){sub 2}(HPO{sub 4}){sup 2{minus}} and Zn(OH){sub 3}(H{sub 2}PO{sub 4}){sup 2{minus}}. A summary of thermochemical properties for species in the systems ZnO-H{sub 2}O and ZnO-Na{sub 2}O-P{sub 2}O{sub 5}-H{sub 2}O is also provided. 21 refs., 10 figs., 7 tabs.

  19. Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research

    Science.gov (United States)

    Reis, Cesar; Akyol, Onat; Ho, Wing Mann; Araujo, Camila; Huang, Lei; Applegate II, Richard

    2017-01-01

    Acute ischemic stroke is a devastating cause of death and disability, consequences of which depend on the time from ischemia onset to treatment, the affected brain region, and its size. The main targets of ischemic stroke therapy aim to restore tissue perfusion in the ischemic penumbra in order to decrease the total infarct area by maintaining blood flow. Advances in research of pathological process and pathways during acute ischemia have resulted in improvement of new treatment strategies apart from restoring perfusion. Additionally, limiting the injury severity by manipulating the molecular mechanisms during ischemia has become a promising approach, especially in animal research. The purpose of this article is to review completed and ongoing phases I and II trials for the treatment of acute ischemic stroke, reviewing studies on antithrombotic, thrombolytic, neuroprotective, and antineuroinflammatory drugs that may translate into more effective treatments. PMID:28286764

  20. Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research.

    Science.gov (United States)

    Reis, Cesar; Akyol, Onat; Ho, Wing Mann; Araujo, Camila; Huang, Lei; Applegate, Richard; Zhang, John H

    2017-01-01

    Acute ischemic stroke is a devastating cause of death and disability, consequences of which depend on the time from ischemia onset to treatment, the affected brain region, and its size. The main targets of ischemic stroke therapy aim to restore tissue perfusion in the ischemic penumbra in order to decrease the total infarct area by maintaining blood flow. Advances in research of pathological process and pathways during acute ischemia have resulted in improvement of new treatment strategies apart from restoring perfusion. Additionally, limiting the injury severity by manipulating the molecular mechanisms during ischemia has become a promising approach, especially in animal research. The purpose of this article is to review completed and ongoing phases I and II trials for the treatment of acute ischemic stroke, reviewing studies on antithrombotic, thrombolytic, neuroprotective, and antineuroinflammatory drugs that may translate into more effective treatments.

  1. Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research

    Directory of Open Access Journals (Sweden)

    Cesar Reis

    2017-01-01

    Full Text Available Acute ischemic stroke is a devastating cause of death and disability, consequences of which depend on the time from ischemia onset to treatment, the affected brain region, and its size. The main targets of ischemic stroke therapy aim to restore tissue perfusion in the ischemic penumbra in order to decrease the total infarct area by maintaining blood flow. Advances in research of pathological process and pathways during acute ischemia have resulted in improvement of new treatment strategies apart from restoring perfusion. Additionally, limiting the injury severity by manipulating the molecular mechanisms during ischemia has become a promising approach, especially in animal research. The purpose of this article is to review completed and ongoing phases I and II trials for the treatment of acute ischemic stroke, reviewing studies on antithrombotic, thrombolytic, neuroprotective, and antineuroinflammatory drugs that may translate into more effective treatments.

  2. Environmental monitoring survey of oil and gas fields in Region II in 2009. Summary report

    Energy Technology Data Exchange (ETDEWEB)

    2010-03-15

    The oil companies Statoil ASA, ExxonMobil Exploration and Production Norway AS, Total E&P Norge AS, Talisman Energy Norge AS and Marathon Petroleum Norge AS commissioned Section of Applied Environmental Research at UNI RESEARCH AS to undertake the monitoring survey of Region II in 2009. Similar monitoring surveys in Region II have been carried out in 1996, 2000, 2003 and 2006. The survey in 2009 included in total 18 fields: Rev, Varg, Sigyn, Sleipner Vest, Sleipner OEst, Sleipner Alfa Nord, Glitne, Grane, Balder, Ringhorne, Jotun, Vale, Skirne, Byggve, Heimdal, Volve, Vilje og Alvheim. Sampling was conducted from the vessel MV Libas between May 18 and May 27. Samples were collected from in totally 137 sampling sites, of which 15 were regional sampling sites. Samples for chemical analysis were collected at all sites, whereas samples for benthos analysis were collected at 12 fields. As in previous surveys, Region II is divided into natural sub-regions. One sub-region is shallow (77-96 m) sub-region, a central sub-region (107-130 m) and a northern subregion (115-119 m). The sediments of the shallow sub-region had relatively lower content of TOM and pelite and higher content of fine sand than the central and northern sub-regions. Calculated areas of contamination are shown for the sub-regions in Table 1.1. The fields Sigyn, Sleipner Alfa Nord, Glitne, Grane, Balder, Ringhorne, Jotun, Skirne, Byggve, Vilje og Alvheim showed no contamination of THC. At the other fields there were minor changes from 2006. The concentrations of barium increased in the central sub-region from 2006 to 2009, also at fields where no drilling had been undertaken during the last years. The same laboratory and methods are used during the three last regional investigations. The changes in barium concentrations may be due to high variability of barium concentrations in the sediments. This is supported by relatively large variations in average barium concentrations at the regional sampling sites in

  3. SNe Ia host galaxy properties from Sloan Digital Sky Survey-II spectroscopy

    CERN Document Server

    Johansson, Jonas; Pforr, Janine; Maraston, Claudia; Nichol, Robert C; Smith, Mathew; Lampeitl, Hubert; Beifiori, Alessandra; Gupta, Ravi R; Schneider, Donald P

    2012-01-01

    We study the stellar populations of SNe Ia host galaxies using SDSS-II spectroscopy. We focus on the relationships of SNe Ia properties with stellar velocity dispersion and the stellar population parameters age, metallicity and element abundance ratios derived by fitting absorption line indices to stellar population models. We concentrate on a sub-sample of 84 SNe Ia from the SDSS-II Supernova Survey. In agreement with previous findings, we find that SALT2 stretch factor values show the strongest dependence on stellar population age. Hence, SNe Ia peak-luminosity is closely related to the age of the stellar progenitor systems, where more luminous SNe Ia appear in younger stellar populations. We find no statistically significant trends in the Hubble residual with any of the stellar population parameters studied, including age and metallicity contrary to the literature, as well as with stellar velocity dispersion. Moreover, we find that the method of stellar mass derivation is affecting the Hubble residual-mass...

  4. Casein Kinase 1 Coordinates Cohesin Cleavage, Gametogenesis, and Exit from M Phase in Meiosis II.

    Science.gov (United States)

    Argüello-Miranda, Orlando; Zagoriy, Ievgeniia; Mengoli, Valentina; Rojas, Julie; Jonak, Katarzyna; Oz, Tugce; Graf, Peter; Zachariae, Wolfgang

    2017-01-09

    Meiosis consists of DNA replication followed by two consecutive nuclear divisions and gametogenesis or spore formation. While meiosis I has been studied extensively, less is known about the regulation of meiosis II. Here we show that Hrr25, the conserved casein kinase 1δ of budding yeast, links three mutually independent key processes of meiosis II. First, Hrr25 induces nuclear division by priming centromeric cohesin for cleavage by separase. Hrr25 simultaneously phosphorylates Rec8, the cleavable subunit of cohesin, and removes from centromeres the cohesin protector composed of shugoshin and the phosphatase PP2A. Second, Hrr25 initiates the sporulation program by inducing the synthesis of membranes that engulf the emerging nuclei at anaphase II. Third, Hrr25 mediates exit from meiosis II by activating pathways that trigger the destruction of M-phase-promoting kinases. Thus, Hrr25 synchronizes formation of the single-copy genome with gamete differentiation and termination of meiosis. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. 37 GHz methanol masers : Horsemen of the Apocalypse for the class II methanol maser phase?

    CERN Document Server

    Ellingsen, S P; Sobolev, A M; Voronkov, M A; Caswell, J L; Lo, N

    2011-01-01

    We report the results of a search for class II methanol masers at 37.7, 38.3 and 38.5 GHz towards a sample of 70 high-mass star formation regions. We primarily searched towards regions known to show emission either from the 107 GHz class II methanol maser transition, or from the 6.035 GHz excited OH transition. We detected maser emission from 13 sources in the 37.7 GHz transition, eight of these being new detections. We detected maser emission from three sources in the 38 GHz transitions, one of which is a new detection. We find that 37.7 GHz methanol masers are only associated with the most luminous 6.7 and 12.2 GHz methanol maser sources, which in turn are hypothesised to be the oldest class II methanol sources. We suggest that the 37.7 GHz methanol masers are associated with a brief evolutionary phase (of 1000-4000 years) prior to the cessation of class II methanol maser activity in the associated high-mass star formation region.

  6. Performance characterization and ground testing of an airborne CO2 differential absorption lidar system (phase II)

    Science.gov (United States)

    Senft, Daniel C.; Fox, Marsha J.; Hamilton, Carla M.; Richter, Dale A.; Higdon, N. S.; Kelly, Brian T.

    1999-05-01

    The Air Force Research Laboratory (AFRL) Active Remote Sensing Branch has developed the Laser Airborne Remote Sensing (LARS) system for chemical detection using the differential absorption lidar (DIAL) technique. The system is based on a high-power CO2 laser which can use either the standard 12C16O2 or the 13C16O2 carbon dioxide isotopes as the lasing medium, and has output energies of up to 5 J on the stronger laser transitions. The lidar system is mounted on a flight-qualified optical breadboard designed for installation into the AFRL Argus C- 135E optical testbed aircraft. The Phase I ground tests were conducted at Kirtland AFB in 1997, prior to the LARS flight tests performed in September 1997 at Kirtland AFB and the Idaho National Engineering and Environmental Laboratory (INEEL). The Phase II ground tests were conducted in 1998 to determine the optimum performance of the LARS system, after the incorporation of modification and improvements suggested by the flight test results. This paper will present some of the chemical detection and radiometric results obtained during the Phase II ground tests.

  7. Observations of the Crab Nebula with H.E.S.S. Phase II

    CERN Document Server

    Holler, M; van Eldik, C; Lenain, J -P; Marandon, V; Murach, T; de Naurois, M; Parsons, R D; Prokoph, H; Zaborov, D

    2015-01-01

    The High Energy Stereoscopic System (H.E.S.S.) phase I instrument was an array of four $100\\,\\mathrm{m}^2$ mirror area Imaging Atmospheric Cherenkov Telescopes (IACTs) that has very successfully mapped the sky at photon energies above $\\sim 100\\,$GeV. Recently, a $600\\,\\mathrm{m}^2$ telescope was added to the centre of the existing array, which can be operated either in standalone mode or jointly with the four smaller telescopes. The large telescope lowers the energy threshold for gamma-ray observations to several tens of GeV, making the array sensitive at energies where the Fermi-LAT instrument runs out of statistics. At the same time, the new telescope makes the H.E.S.S. phase II instrument. This is the first hybrid IACT array, as it operates telescopes of different size (and hence different trigger rates) and different field of view. In this contribution we present results of H.E.S.S. phase II observations of the Crab Nebula, compare them to earlier observations, and evaluate the performance of the new ins...

  8. Turnable Semiconductor Laser Spectroscopy in Hollow Optical Waveguides, Phase II SBIR

    Energy Technology Data Exchange (ETDEWEB)

    Gregory J. Fetzer, Ph.D.

    2001-12-24

    In this study a novel optical trace gas sensor based on a perforated hollow waveguide (PHW) was proposed. The sensor has been given the acronym ESHOW for Environmental Sensor using Hollow Optical Waveguides. Realizations of the sensor have demonstrated rapid response time (<2s), low minimum detection limits (typically around 3 x 10-5 absorbance). Operation of the PHW technology has been demonstrated in the near-infrared (NIR) and mid0infrared (MIR) regions of the spectrum. Simulation of sensor performance provided in depth understanding of the signals and signal processing required to provide high sensitivity yet retain rapid response to gas changes. A dedicated sensor electronics and software foundation were developed during the course of the Phase II effort. Commercial applications of the sensor are ambient air and continuous emissions monitoring, industrial process control and hazardous waste site monitoring. There are numerous other applications for such a sensor including medical diagnosis and treatment, breath analysis for legal purposes, water quality assessment, combustion diagnostics, and chemical process control. The successful completion of Phase II resulted in additional funding of instrument development by the Nations Institute of Heath through a Phase I SBIR grant and a strategic teaming relationship with a commercial manufacture of medical instrumentation. The purpose of the NIH grant and teaming relationship is to further develop the sensor to monitor NO in exhaled breath for the purposes of asthma diagnosis.

  9. Predicted Geology of the Pahute Mesa-Oasis Valley Phase II Drilling Initiative

    Energy Technology Data Exchange (ETDEWEB)

    NSTec Environmental Restoration

    2009-04-20

    Pahute Mesa–Oasis Valley (PM-OV) Phase II drilling will occur within an area that encompasses approximately 117 square kilometers (45 square miles) near the center of the Phase I PM-OV hydrostratigraphic framework model area. The majority of the investigation area lies within dissected volcanic terrain between Pahute Mesa on the north and Timber Mountain on the south. This area consists of a complex distribution of volcanic tuff and lava of generally rhyolitic composition erupted from nearby calderas and related vents. Several large buried volcanic structural features control the distribution of volcanic units in the investigation area. The Area 20 caldera, including its structural margin and associated caldera collapse collar, underlies the northeastern portion of the investigation area. The southern half of the investigation area lies within the northwestern portion of the Timber Mountain caldera complex, including portions of the caldera moat and resurgent dome. Another significant structural feature in the area is the west-northwest-trending Northern Timber Mountain moat structural zone, which bisects the northern portion of the investigation area and forms a structural bench. The proposed wells of the UGTA Phase II drilling initiative can be grouped into four generalized volcanic structural domains based on the stratigraphic distribution and structural position of the volcanic rocks in the upper 1,000 meters (3,300 feet) of the crust, a depth that represents the approximate planned total depths of the proposed wells.

  10. Catalytic conversion of light alkanes phase II. Topical report, January 1990--January 1993

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-31

    The Topical Report on Phase II of the project entitled, Catalytic Conversion of Light Alkanes reviews work done between January 1, 1990 and September 30, 1992 on the Cooperative Agreement. The mission of this work is to devise a new catalyst which can be used in a simple economic process to convert the light alkanes in natural gas to oxygenate products which can either be used as clean-burning, high octane liquid fuels, as fuel components or as precursors to liquid hydrocarbon transportation fuel. This Topical Report documents our efforts to design, prepare, characterize and test novel catalysts for the mild selective reaction of light hydrocarbons with air or oxygen to produce alcohols directly. These catalysts are designed to form active metal oxo (MO) species and to be uniquely active for the homolytic cleavage of the carbon-hydrogen bonds in light alkanes producing intermediates which can form alcohols. Research on the Cooperative Agreement is divided into three Phases relating to three molecular environments for the active catalytic species that we are trying to generate. In this report we present our work on catalysts which have oxidation-active metals in polyoxoanions (PHASE II).

  11. The International Deep Planet Survey II: The frequency of directly imaged giant exoplanets with stellar mass

    CERN Document Server

    Galicher, Raphael; Macintosh, Bruce; Zuckerman, Ben; Barman, Travis; Konopacky, Quinn; Song, Inseok; Patience, Jenny; Lafreniere, David; Doyon, Rene; Nielsen, Eric L

    2016-01-01

    Radial velocity and transit methods are effective for the study of short orbital period exoplanets but they hardly probe objects at large separations for which direct imaging can be used. We carried out the international deep planet survey of 292 young nearby stars to search for giant exoplanets and determine their frequency. We developed a pipeline for a uniform processing of all the data that we have recorded with NIRC2/Keck II, NIRI/Gemini North, NICI/Gemini South, and NACO/VLT for 14 years. The pipeline first applies cosmetic corrections and then reduces the speckle intensity to enhance the contrast in the images. The main result of the international deep planet survey is the discovery of the HR 8799 exoplanets. We also detected 59 visual multiple systems including 16 new binary stars and 2 new triple stellar systems, as well as 2,279 point-like sources. We used Monte Carlo simulations and the Bayesian theorem to determine that 1.05[+2.80-0.70]% of stars harbor at least one giant planet between 0.5 and 14...

  12. The Rise and Fall of Type Ia Supernova Light Curves in the SDSS-II Supernova Survey

    CERN Document Server

    Hayden, Brian T; Kessler, Richard; Frieman, Joshua A; Jha, Saurabh W; Cinabro, David; Dilday, Benjamin; Kasen, Daniel; Marriner, John; Nichol, Robert C; Riess, Adam G; Sako, Masao; Schneider, Donald P; Smith, Mathew; Sollerman, Jesper; Bassett, Bruce

    2010-01-01

    We analyze the rise and fall times of type Ia supernova (SN Ia) light curves discovered by the SDSS-II Supernova Survey. From a set of 391 light curves k-corrected to the rest frame B and V bands, we find a smaller dispersion in the rising portion of the light curve compared to the decline. This is in qualitative agreement with computer models which predict that variations in radioactive nickel yield have less impact on the rise than on the spread of the decline rates. The differences we find in the rise and fall properties suggest that a single 'stretch' correction to the light curve phase does not properly model the range of SN Ia light curve shapes. We select a subset of 105 light curves well-observed in both rise and fall portions of the light curves and develop a '2-stretch' fit algorithm which estimates the rise and fall times independently. We find the average time from explosion to B-band peak brightness is 17.38 +/- 0.17 days. Our average rise time is shorter than the 19.5 days found in previous stud...

  13. Phase II TPDCV protocol for pediatric low-grade hypothalamic/chiasmatic gliomas: 15-year update

    Science.gov (United States)

    Mishra, Kavita K.; Squire, Sarah; Lamborn, Kathleen; Banerjee, Anuradha; Gupta, Nalin; Wara, William M.; Prados, Michael D.; Berger, Mitchel S.

    2010-01-01

    To report long-term results for children with low-grade hypothalamic/chiasmatic gliomas treated on a phase II chemotherapy protocol. Between 1984 and 1992, 33 children with hypothalamic/chiasmatic LGGs received TPDCV chemotherapy on a phase II prospective trial. Median age was 3.0 years (range 0.3–16.2). Twelve patients (36%) underwent STRs, 14 (42%) biopsy only, and seven (21%) no surgery. Twenty patients (61%) had pathologic JPAs, nine (27%) grade II gliomas, and four (12%) no surgical sampling. Median f/u for surviving patients was 15.2 years (range 5.3–20.7); 20 of the 23 surviving patients had 14 or more years of follow-up. Fifteen-year PFS and OS were 23.4 and 71.2%, respectively. Twenty-five patients progressed, of whom 13 are NED, two are AWD, and 10 have died. All children who died were diagnosed and first treated at age three or younger. Age at diagnosis was significantly associated with relapse and survival (P = 0.004 for PFS and P = 0.037 for OS). No PFS or OS benefit was seen with STR versus biopsy/no sampling (P = 0.58 for PFS, P = 0.59 for OS). For patients with JPAs and WHO grade II tumors, the 15-year PFS was 18.8 and 22.2% (P = 0.95) and 15-year OS was 73.7 and 55.6% (P = 0.17), respectively. Upfront TPDCV for children with hypothalamic/chiasmatic LGGs resulted in 15-year OS of 71.2% and 15-year PFS of 23.4%. No survival benefit is demonstrated for greater extent of resection. Age is a significant prognostic factor for progression and survival. PMID:20221671

  14. Upper crustal structure from the Santa Monica Mountains to the Sierra Nevada, Southern California: Tomographic results from the Los Angeles Regional Seismic Experiment, Phase II (LARSE II)

    Science.gov (United States)

    Lutter, W.J.; Fuis, G.S.; Ryberg, T.; Okaya, D.A.; Clayton, R.W.; Davis, P.M.; Prodehl, C.; Murphy, J.M.; Langenheim, V.E.; Benthien, M.L.; Godfrey, N.J.; Christensen, N.I.; Thygesen, K.; Thurber, C.H.; Simila, G.; Keller, Gordon R.

    2004-01-01

    In 1999, the U.S. Geological Survey and the Southern California Earthquake Center (SCEC) collected refraction and low-fold reflection data along a 150-km-long corridor extending from the Santa Monica Mountains northward to the Sierra Nevada. This profile was part of the second phase of the Los Angeles Region Seismic Experiment (LARSE II). Chief imaging targets included sedimentary basins beneath the San Fernando and Santa Clarita Valleys and the deep structure of major faults along the transect, including causative faults for the 1971 M 6.7 San Fernando and 1994 M 6.7 Northridge earthquakes, the San Gabriel Fault, and the San Andreas Fault. Tomographic modeling of first arrivals using the methods of Hole (1992) and Lutter et al. (1999) produces velocity models that are similar to each other and are well resolved to depths of 5-7.5 km. These models, together with oil-test well data and independent forward modeling of LARSE II refraction data, suggest that regions of relatively low velocity and high velocity gradient in the San Fernando Valley and the northern Santa Clarita Valley (north of the San Gabriel Fault) correspond to Cenozoic sedimentary basin fill and reach maximum depths along the profile of ???4.3 km and >3 km , respectively. The Antelope Valley, within the western Mojave Desert, is also underlain by low-velocity, high-gradient sedimentary fill to an interpreted maximum depth of ???2.4 km. Below depths of ???2 km, velocities of basement rocks in the Santa Monica Mountains and the central Transverse Ranges vary between 5.5 and 6.0 km/sec, but in the Mojave Desert, basement rocks vary in velocity between 5.25 and 6.25 km/sec. The San Andreas Fault separates differing velocity structures of the central Transverse Ranges and Mojave Desert. A weak low-velocity zone is centered approximately on the north-dipping aftershock zone of the 1971 San Fernando earthquake and possibly along the deep projection of the San Gabriel Fault. Modeling of gravity data, using

  15. A phase II study of combination chemotherapy in early relapsed epithelial ovarian cancer using gemcitabine and pegylated liposomal doxorubicin

    DEFF Research Database (Denmark)

    Mirza, Mansoor Raza; Lund, Bente; Lindegaard, Jacob Christian

    2010-01-01

    Treatment of epithelial ovarian cancer patients relapsing with a short treatment-free interval (TFI) after prior chemotherapy is unsatisfactory. This phase II trial evaluated the activity and feasibility of pegylated liposomal doxorubicin (PLD) plus gemcitabine in this setting.......Treatment of epithelial ovarian cancer patients relapsing with a short treatment-free interval (TFI) after prior chemotherapy is unsatisfactory. This phase II trial evaluated the activity and feasibility of pegylated liposomal doxorubicin (PLD) plus gemcitabine in this setting....

  16. Low Energy Threshold Analysis of the Phase I and Phase II Data Sets of the Sudbury Neutrino Observatory

    CERN Document Server

    ,

    2009-01-01

    Results are reported from a joint analysis of Phase I and Phase II data from the Sudbury Neutrino Observatory. The effective electron kinetic energy threshold used is T_eff=3.5 MeV, the lowest analysis threshold yet achieved with water Cherenkov detector data. In units of 10^6 cm^{-2} s^{-1}, the total flux of active-flavor neutrinos from 8B decay in the Sun measured using the neutral current (NC) reaction of neutrinos on deuterons, with no constraint on the 8B neutrino energy spectrum, is found to be Phi_NC = 5.140 ^{+0.160}_{-0.158} (stat) ^{+0.132}_{-0.117} (syst). These uncertainties are more than a factor of two smaller than previously published results. Also presented are the spectra of recoil electrons from the charged current reaction of neutrinos on deuterons and the elastic scattering of electrons. A fit to the SNO data in which the free parameters directly describe the total 8B neutrino flux and the energy-dependent nu_e survival probability provides a measure of the total 8B neutrino flux Phi_8B =...

  17. A design of phase II cancer trials using total and complete response endpoints.

    Science.gov (United States)

    Lu, Ying; Jin, Hua; Lamborn, Kathleen R

    2005-10-30

    Phase II clinical trials in oncology are used for initial evaluation of the therapeutic efficacy of a new treatment regimen. Simon's two-stage design based on total response (TR) rate is commonly used for such trials. Several authors have proposed alternative strategies to consider either response and toxicity or response and early progression. Because TR consists of both partial response (PR) and complete response (CR) and these two types of responses have different effects on subsequent patient outcome, Lin and Chen proposed a flexible design that is based on a weighted average of PR and CR rates as a way to recognize the differential significance of the two levels of response. Panageas and colleagues, on the other hand, used a trinomial model and direct search to consider a rejection region for PR and CR separately. In this paper, we reformat their hypotheses to assess efficacy based on TR and CR. A new two-stage optimum phase II trial design based on TR and CR is developed. We provide guides on searching the stopping and rejecting regions and on determining sample size. An example of a phase II trial for glioblastomas treatment is presented. In this trial, physicians would be interested in either stable disease (SD), PR, or CR as an indication of efficacy. However, because PR and CR rarely occur, observation of any PR or CR will lean towards acceptance of the treatment. Our design has the advantage of being close to the traditional Simon two-stage design while still having the flexibility to treat responses (PR and CR in this example) differently than SD.

  18. In Vivo Exposure of Kaempferol Is Driven by Phase II Metabolic Enzymes and Efflux Transporters.

    Science.gov (United States)

    Zheng, Liang; Zhu, Lijun; Zhao, Min; Shi, Jian; Li, Yuhuan; Yu, Jia; Jiang, Huangyu; Wu, Jinjun; Tong, Yunli; Liu, Yuting; Hu, Ming; Lu, Linlin; Liu, Zhongqiu

    2016-09-01

    Kaempferol is a well-known flavonoid; however, it lacks extensive pharmacokinetic studies. Phase II metabolic enzymes and efflux transporters play an important role in the disposition of flavonoids. This study aimed to investigate the mechanism by which phase II metabolic enzymes and efflux transporters determine the in vivo exposure of kaempferol. Pharmacokinetic analysis in Sprague-Dawley rats revealed that kaempferol was mostly biotransformed to conjugates, namely, kaempferol-3-glucuronide (K-3-G), kaempferol-7-glucuronide (K-7-G), and kaempferol-7-sulfate, in plasma. K-3-G represented the major metabolite. Compared with that in wild-type mice, pharmacokinetics in knockout FVB mice demonstrated that the absence of multidrug resistance protein 2 (MRP2) and breast cancer resistance protein (BCRP) significantly increased the area under the curve (AUC) of the conjugates. The lack of MRP1 resulted in a much lower AUC of the conjugates. Intestinal perfusion in rats revealed that the glucuronide conjugates were mainly excreted in the small intestine, but 7-sulfate was mainly excreted in the colon. In Caco-2 monolayers, K-7-G efflux toward the apical (AP) side was significantly higher than K-3-G efflux. In contrast, K-3-G efflux toward the basolateral (BL) side was significantly higher than K-7-G efflux. The BL-to-AP efflux was significantly reduced in the presence of the MRP2 inhibitor LTC4. The AP-to-BL efflux was significantly decreased in the presence of the BL-side MRPs inhibitor MK571. The BCRP inhibitor Ko143 decreased the glucuronide conjugate efflux. Therefore, kaempferol is mainly exposed as K-3-G in vivo, which is driven by phase II metabolic enzymes and efflux transporters (i.e., BCRP and MRPs).

  19. A phase II study of thalidomide in patients with brain metastases from malignant melanoma

    DEFF Research Database (Denmark)

    Vestermark, Lene; Larsen, Susanne; Lindeløv, Birgit;

    2008-01-01

    Introduction. Brain metastases develop in nearly half of the patients with advanced melanoma and in 15 to 20% of these patients CNS is the first site of relapse. Overall median survival is short, ranging from 2 to 4 months. Thalidomide has antiangiogenic and immunomodulatory effects. Results...... obtained in prior trials indicate that Thalidomide acts as a cytostatic agent in metastatic melanoma. We evaluated single agent antitumour activity and toxicity of Thalidomide in a phase II setting in patients with brain metastases associated with metastatic melanoma. Material and methods. Patients...

  20. A Disposable Microfluidic Device with a Screen Printed Electrode for Mimicking Phase II Metabolism

    Directory of Open Access Journals (Sweden)

    Rafaela Vasiliadou

    2016-09-01

    Full Text Available Human metabolism is investigated using several in vitro methods. However, the current methodologies are often expensive, tedious and complicated. Over the last decade, the combination of electrochemistry (EC with mass spectrometry (MS has a simpler and a cheaper alternative to mimic the human metabolism. This paper describes the development of a disposable microfluidic device with a screen-printed electrode (SPE for monitoring phase II GSH reactions. The proposed chip has the potential to be used as a primary screening tool, thus complementing the current in vitro methods.

  1. Nine-year change in statistical design, profile, and success rates of Phase II oncology trials.

    Science.gov (United States)

    Ivanova, Anastasia; Paul, Barry; Marchenko, Olga; Song, Guochen; Patel, Neerali; Moschos, Stergios J

    2016-01-01

    We investigated nine-year trends in statistical design and other features of Phase II oncology clinical trials published in 2005, 2010, and 2014 in five leading oncology journals: Cancer, Clinical Cancer Research, Journal of Clinical Oncology, Annals of Oncology, and Lancet Oncology. The features analyzed included cancer type, multicenter vs. single-institution, statistical design, primary endpoint, number of treatment arms, number of patients per treatment arm, whether or not statistical methods were well described, whether the drug was found effective based on rigorous statistical testing of the null hypothesis, and whether the drug was recommended for future studies.

  2. Summary of WPT FOA phase II demonstration performed on July 21, 2015

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Perry T. [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States); Onar, Omer C. [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

    2015-08-01

    This summary provides details of the activities, presentations and hardware demonstrations performed at the International Transportation Innovation Center (iTiC) in Greenville, South Carolina as deliverables for the wireless power transfer (WPT) FOA #000667 phase II gateway. This report does not attempt to identify all encompassing efforts from each of the partners leading up to the demonstration, but will attempt to provide a record which briefly describes the project deliverables met and expectations from the Department of Energy (DOE) as action items agreed to during the wrap-up session on July 21, 2015.

  3. The multifaceted Type II-L supernova 2014G from pre-maximum to nebular phase

    Science.gov (United States)

    Terreran, G.; Jerkstrand, A.; Benetti, S.; Smartt, S. J.; Ochner, P.; Tomasella, L.; Howell, D. A.; Morales-Garoffolo, A.; Harutyunyan, A.; Kankare, E.; Arcavi, I.; Cappellaro, E.; Elias-Rosa, N.; Hosseinzadeh, G.; Kangas, T.; Pastorello, A.; Tartaglia, L.; Turatto, M.; Valenti, S.; Wiggins, P.; Yuan, F.

    2016-10-01

    We present multiband ultraviolet, optical, and near-infrared photometry, along with visual-wavelength spectroscopy, of supernova (SN) 2014G in the nearby galaxy NGC 3448 (25 Mpc). The early-phase spectra show strong emission lines of the high ionization species He II/N IV/C IV during the first 2-3 d after explosion, traces of a metal-rich circumstellar material (CSM) probably due to pre-explosion mass-loss events. These disappear by day 9 and the spectral evolution then continues matching that of normal Type II SNe. The post-maximum light curve declines at a rate typical of Type II-L class. The extensive photometric coverage tracks the drop from the photospheric stage and constrains the radioactive tail, with a steeper decline rate than that expected from the 56Co decay if γ-rays are fully trapped by the ejecta. We report the appearance of an unusual feature on the blue side of H α after 100 d, which evolves to appear as a flat spectral feature linking H α and the [O I] doublet. This may be due to interaction of the ejecta with a strongly asymmetric, and possibly bipolar CSM. Finally, we report two deep spectra at ˜190 and 340 d after explosion, the latter being arguably one of the latest spectra for a Type II-L SN. By modelling the spectral region around the [Ca II], we find a supersolar Ni/Fe production. The strength of the [O I] λλ6300,6363 doublet, compared with synthetic nebular spectra, suggests a progenitor with a zero-age main-sequence mass between 15 and 19 M⊙.

  4. Review of Development Survey of Phase Change Material Models in Building Applications

    Directory of Open Access Journals (Sweden)

    Hussein J. Akeiber

    2014-01-01

    Full Text Available The application of phase change materials (PCMs in green buildings has been increasing rapidly. PCM applications in green buildings include several development models. This paper briefly surveys the recent research and development activities of PCM technology in building applications. Firstly, a basic description of phase change and their principles is provided; the classification and applications of PCMs are also included. Secondly, PCM models in buildings are reviewed and discussed according to the wall, roof, floor, and cooling systems. Finally, conclusions are presented based on the collected data.

  5. Near-term electric-vehicle program. Phase II. Mid-term review summary report

    Energy Technology Data Exchange (ETDEWEB)

    1978-07-27

    The general objective of the Near-Term Electric Vehicle Program is to confirm that, in fact, the complete spectrum of requirements placed on the automobile (e.g., safety, producibility, utility, etc.) can still be satisfied if electric power train concepts are incorporated in lieu of contemporary power train concepts, and that the resultant set of vehicle characteristics are mutually compatible, technologically achievable, and economically achievable. The focus of the approach to meeting this general objective involves the design, development, and fabrication of complete electric vehicles incorporating, where necessary, extensive technological advancements. A mid-term summary is presented of Phase II which is a continuation of the preliminary design study conducted in Phase I of the program. Information is included on vehicle performance and performance simulation models; battery subsystems; control equipment; power systems; vehicle design and components for suspension, steering, and braking; scale model testing; structural analysis; and vehicle dynamics analysis. (LCL)

  6. Fireside corrosion testing of candidate superheater tube alloys, coatings, and claddings - phase II

    Energy Technology Data Exchange (ETDEWEB)

    Blough, J.L.; Stanko, G.J. [Foster Wheeler Development Corp., Livingston, NJ (United States)

    1996-08-01

    In Phase I a variety of developmental and commercial tubing alloys and claddings were exposed to laboratory fireside corrosion testing simulating a superheater or reheater in a coal-fired boiler. Phase II (in situ testing) has exposed samples of 347, RA-8511, HR3C, 253MA, Fe{sub 3}Al + 5Cr, 310 modified, 800HT, NF 709, 690 clad, and 671 clad for over 10,000 hours to the actual operating conditions of a 250-MW coal-fired boiler. The samples were installed on an air-cooled, retractable corrosion probe, installed in the reheater cavity, and controlled to the operating metal temperatures of an existing and advanced-cycle coal-fired boiler. Samples of each alloy will be exposed for 4000, 12,000, and 16,000 hours of operation. The results will be presented for the metallurgical examination of the corrosion probe samples after 4000 hours of exposure.

  7. Reactor physics studies in the GCFR phase-II critical assembly

    Energy Technology Data Exchange (ETDEWEB)

    Pond, R B [ed.

    1976-09-01

    The reactor physics studies performed in the gas cooled fast reactor (GCFR) mockup on ZPR-9 are covered. This critical assembly, designated Phase II in the GCFR program, had a single zone PuO/sub 2/-UO/sub 2/ core composition and UO/sub 2/ radial and axial blankets. The assembly was built both with and without radial and axial stainless steel reflectors. The program included the following measurements: small-sample reactivity worths of reactor constituent materials (including helium); /sup 238/U Doppler effect; uranium and plutonium reaction rate distributions; thorium, uranium, and plutonium ..cap alpha.. and reactor kinetics. Analysis of the measurements used ENDF/B-IV nuclear data; anisotropic diffusion coefficients were used to account for neutron streaming effects. Comparison of measurements and calculations to GCFR Phase I are also made.

  8. Direct heat resource assessment: Phase II, year 1. Final report, February 1, 1979-January 31, 1980

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, D.M.; Cox, M.E.; Kauahikaua, J.P.; Mattice, M.D.

    1980-02-01

    During 1979 reconnaissance field surveys were conducted on the islands of Hawaii, Maui, and Oahu with the objective of confirming groundwater chemical data and geophysical data compiled during the preliminary regional assessment of Phase I of the Direct Heat Resource Assessment Program. The exploration techniques applied include (1) groundwater chemistry, (2) mercury-radon surveys, (3) isotopic composition of groundwaters, (4) time domain electromagnetics, and (5) Schlumberger resistivity surveys. The results of these surveys can be classified as follows: (1) Hawaii: Kailua-Kona, strong geochemical anomalies; Kawaihae, strong geophysical anomalies, moderate to strong geochemical anomalies; Hualalai northwest rift, weak geochemical and moderate geophysical anomalies; South Point, moderate to weak geophysical anomalies; Hualalai southeast rift, weak geophysical anomalies; Keaau, weak geophysical and geochemical anomalies; (2) Maui: Haiku-Paia, strong geochemical anomalies; Olowalu-Ukamehame canyons, moderate to strong geochemical and geophysical anomalies; Lahaina, weak geochemical and geophysical anomalies; (3) Oahu: Lualualei, moderate to strong geochemical and geophysical anomalies; Waimanalo-Maunawili, insufficient data.

  9. Electrodril system field test program. Phase II: Task C-1-deep drilling system demonstration. Final report for Phase II: Task C-1

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, P D

    1981-04-01

    The Electrodril Deep Drilling System field test demonstrations were aborted in July 1979, due to connector problems. Subsequent post test analyses concluded that the field replacable connectors were the probable cause of the problems encountered. The designs for both the male and female connectors, together with their manufacturing processes, were subsequently modified, as was the acceptance test procedures. A total of nine male and nine female connectors were manufactured and delivered during the 2nd Quarter 1980. Exhaustive testing was then conducted on each connector as a precursor to formal qualification testing conducted during the month of October 1980, at the Brown Oil Tool test facility located in Houston, Texas. With this report, requirements under Phase II, Task C-1 are satisfied. The report documents the results of the connector qualification test program which was successfully completed October 28, 1980. In general, it was concluded that connector qualification had been achieved and plans are now in progress to resume the field test demonstration program so that Electrodril System performance predictions and economic viability can be evaluated.

  10. Electrodril system field test program. Phase II: Task C-1-deep drilling system demonstration. Final report for Phase II: Task C-1

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, P D

    1981-04-01

    The Electrodril Deep Drilling System field test demonstrations were aborted in July 1979, due to connector problems. Subsequent post test analyses concluded that the field replacable connectors were the probable cause of the problems encountered. The designs for both the male and female connectors, together with their manufacturing processes, were subsequently modified, as was the acceptance test procedures. A total of nine male and nine female connectors were manufactured and delivered during the 2nd Quarter 1980. Exhaustive testing was then conducted on each connector as a precursor to formal qualification testing conducted during the month of October 1980, at the Brown Oil Tool test facility located in Houston, Texas. With this report, requirements under Phase II, Task C-1 are satisfied. The report documents the results of the connector qualification test program which was successfully completed October 28, 1980. In general, it was concluded that connector qualification had been achieved and plans are now in progress to resume the field test demonstration program so that Electrodril System performance predictions and economic viability can be evaluated.

  11. The International Deep Planet Survey. II. The frequency of directly imaged giant exoplanets with stellar mass

    Science.gov (United States)

    Galicher, R.; Marois, C.; Macintosh, B.; Zuckerman, B.; Barman, T.; Konopacky, Q.; Song, I.; Patience, J.; Lafrenière, D.; Doyon, R.; Nielsen, E. L.

    2016-10-01

    Context. Radial velocity and transit methods are effective for the study of short orbital period exoplanets but they hardly probe objects at large separations for which direct imaging can be used. Aims: We carried out the international deep planet survey of 292 young nearby stars to search for giant exoplanets and determine their frequency. Methods: We developed a pipeline for a uniform processing of all the data that we have recorded with NIRC2/Keck II, NIRI/Gemini North, NICI/Gemini South, and NACO/VLT for 14 yr. The pipeline first applies cosmetic corrections and then reduces the speckle intensity to enhance the contrast in the images. Results: The main result of the international deep planet survey is the discovery of the HR 8799 exoplanets. We also detected 59 visual multiple systems including 16 new binary stars and 2 new triple stellar systems, as well as 2279 point-like sources. We used Monte Carlo simulations and the Bayesian theorem to determine that 1.05+2.80-0.70% of stars harbor at least one giant planet between 0.5 and 14 MJ and between 20 and 300 AU. This result is obtained assuming uniform distributions of planet masses and semi-major axes. If we consider power law distributions as measured for close-in planets instead, the derived frequency is 2.30+5.95-1.55%, recalling the strong impact of assumptions on Monte Carlo output distributions. We also find no evidence that the derived frequency depends on the mass of the hosting star, whereas it does for close-in planets. Conclusions: The international deep planet survey provides a database of confirmed background sources that may be useful for other exoplanet direct imaging surveys. It also puts new constraints on the number of stars with at least one giant planet reducing by a factor of two the frequencies derived by almost all previous works. Tables 11-15 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc

  12. Hydra II: A Faint and Compact Milky Way Dwarf Galaxy Found in the Survey of the Magellanic Stellar History

    NARCIS (Netherlands)

    Martin, Nicolas F.; Nidever, David L.; Besla, Gurtina; Olsen, Knut; Walker, Alistair R.; Vivas, A. Katherina; Gruendl, Robert A.; Kaleida, Catherine C.; Muñoz, Ricardo R.; Blum, Robert D.; Saha, Abhijit; Conn, Blair C.; Bell, Eric F.; Chu, You-Hua; Cioni, Maria-Rosa L.; de Boer, Thomas J. L.; Gallart, Carme; Jin, Shoko; Kunder, Andrea; Majewski, Steven R.; Martinez-Delgado, David; Monachesi, Antonela; Monelli, Matteo; Monteagudo, Lara; Noël, Noelia E. D.; Olszewski, Edward W.; Stringfellow, Guy S.; van der Marel, Roeland P.; Zaritsky, Dennis

    We present the discovery of a new dwarf galaxy, Hydra II, found serendipitously within the data from the ongoing Survey of the Magellanic Stellar History conducted with the Dark Energy Camera on the Blanco 4 m Telescope. The new satellite is compact ({{r}h}=68 ± 11 pc) and faint ({{M}V}=-4.8 ± 0.3),

  13. SN 2006oz: rise of a super-luminous supernova observed by the SDSS-II SN Survey

    DEFF Research Database (Denmark)

    Leloudas, Georgios; Chatzopoulos, E.; Dilday, B.;

    2012-01-01

    to contribute to a better understanding of these objects by studying SN 2006oz, a newly-recognized member of this class. Methods. We present multi-color light curves of SN 2006oz from the SDSS-II SN Survey that cover its rise time, as well as an optical spectrum that shows that the explosion occurred at z ~ 0...

  14. Hanna, Wyoming underground coal gasification data base. Volume 3. The Hanna II, Phase I field test

    Energy Technology Data Exchange (ETDEWEB)

    Bartke, T.C.; Fischer, D.D.; King, S.B.; Boyd, R.M.; Humphrey, A.E.

    1985-08-01

    This report is part of a seven-volume series on the Hanna, Wyoming, underground coal gasification field tests. Volume 1 is a summary of the project, and each of Volumes 2 through 6 describes a particular test. Volume 7 is a compilation of all the data for the tests in Volumes 2 through 6. Hanna II, Phase I was conducted during the spring and summer of 1975, at a site about 700 feet up dip (to the southwest) of the Hanna I test. The test was conducted in two stages - Phase IA and IB. Phase IA consisted of linking and gasification operations between Wells 1 and 3 and Phase IB of linking from the 1-3 gasification zone to Well 2, followed by a short period of gasification from Well 2 to Well 3 over a broad range of air injection rates, in order to determine system turndown capabilities and response times. This report covers: (1) site selection and characteristics; (2) test objectives; (3) facilities description; (4) pre-operational testing; (5) test operations summary; and (6) post-test activity. 7 refs., 11 figs., 8 tabs.

  15. Hopelessness across phases of bipolar I or II disorder: a prospective study.

    Science.gov (United States)

    Valtonen, Hanna M; Suominen, Kirsi; Haukka, Jari; Mantere, Outi; Arvilommi, Petri; Leppämäki, Sami; Isometsä, Erkki T

    2009-05-01

    Hopelessness, a key risk factor for suicidal behaviour overall, has been studied little among bipolar disorder (BD) patients. For purposes of prevention, it is important to know whether it is predominantly a patient's permanent trait or merely reflects the highly variable illness states. We investigated the degree to which hopelessness is trait- or state-related during the course of BD. The Jorvi Bipolar Study (JoBS) is a naturalistic prospective study representing psychiatric in- and outpatients with DSM-IV BD I and II. Repeated measurements with the Beck Hopelessness Scale of 188 patients at baseline, 6 months and 18 months were analysed using a linear regression model with general estimation equations. Factors covarying with hopelessness during follow-up were investigated. Levels of hopelessness varied markedly between illness phases, being highest in depressive and mixed phases, and lowest in euthymia, hypomania or mania. Hopelessness was independently associated with concurrent severity of depression (estimate 0.231, phopelessness during follow-up was previous hopelessness (0.403, pdepressive mixed phases. Hopelessness was measured at only three time-points. Level of hopelessness varies markedly between patients in different phases of BD, but is also, to a degree, a permanent feature. Among BD patients, hopelessness appears to be both a trait- and state-related characteristic.

  16. Deep Chandra Survey of the Small Magellanic Cloud. II. Timing Analysis of X-Ray Pulsars

    Science.gov (United States)

    Hong, JaeSub; Antoniou, Vallia; Zezas, Andreas; Haberl, Frank; Sasaki, Manami; Drake, Jeremy J.; Plucinsky, Paul P.; Laycock, Silas

    2017-09-01

    We report the timing analysis results of X-ray pulsars from a recent deep Chandra survey of the Small Magellanic Cloud (SMC). We analyzed a total exposure of 1.4 Ms from 31 observations over a 1.2 deg2 region in the SMC under a Chandra X-ray Visionary Program. Using the Lomb–Scargle and epoch-folding techniques, we detected periodic modulations from 20 pulsars and a new candidate pulsar. The survey also covered 11 other pulsars with no clear sign of periodic modulation. The 0.5–8 keV X-ray luminosity (L X ) of the pulsars ranges from 1034 to 1037 erg s‑1 at 60 kpc. All of the Chandra sources with L X ≳ 4 × 1035 erg s‑1 exhibit X-ray pulsations. The X-ray spectra of the SMC pulsars (and high-mass X-ray binaries) are in general harder than those of the SMC field population. All but SXP 8.02 can be fitted by an absorbed power-law model with a photon index of Γ ≲ 1.5. The X-ray spectrum of the known magnetar SXP 8.02 is better fitted with a two-temperature blackbody model. Newly measured pulsation periods of SXP 51.0, SXP 214, and SXP 701, are significantly different from the previous XMM-Newton and RXTE measurements. This survey provides a rich data set for energy-dependent pulse profile modeling. Six pulsars show an almost eclipse-like dip in the pulse profile. Phase-resolved spectral analysis reveals diverse spectral variations during pulsation cycles: e.g., for an absorbed power-law model, some exhibit an (anti)-correlation between absorption and X-ray flux, while others show more intrinsic spectral variation (i.e., changes in photon indices).

  17. A modified varying-stage adaptive phase II/III clinical trial design.

    Science.gov (United States)

    Dong, Gaohong; Vandemeulebroecke, Marc

    2016-07-01

    Conventionally, adaptive phase II/III clinical trials are carried out with a strict two-stage design. Recently, a varying-stage adaptive phase II/III clinical trial design has been developed. In this design, following the first stage, an intermediate stage can be adaptively added to obtain more data, so that a more informative decision can be made. Therefore, the number of further investigational stages is determined based upon data accumulated to the interim analysis. This design considers two plausible study endpoints, with one of them initially designated as the primary endpoint. Based on interim results, another endpoint can be switched as the primary endpoint. However, in many therapeutic areas, the primary study endpoint is well established. Therefore, we modify this design to consider one study endpoint only so that it may be more readily applicable in real clinical trial designs. Our simulations show that, the same as the original design, this modified design controls the Type I error rate, and the design parameters such as the threshold probability for the two-stage setting and the alpha allocation ratio in the two-stage setting versus the three-stage setting have a great impact on the design characteristics. However, this modified design requires a larger sample size for the initial stage, and the probability of futility becomes much higher when the threshold probability for the two-stage setting gets smaller. Copyright © 2016 John Wiley & Sons, Ltd.

  18. Wheat bran feruloyl oligosaccharides modulate the phase II detoxifying/antioxidant enzymes via Nrf2 signaling.

    Science.gov (United States)

    Zhang, Huijuan; Wang, Jing; Liu, Yingli; Sun, Baoguo

    2015-03-01

    The antioxidant activities of wheat bran feruloyl oligosaccharides (FOs) were determined in rats by determining the activities and mRNA expression levels of phase II detoxifying/antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and heme oxygenase-1 (HO-1) in rat organs. FOs was given by gavage at doses of 0.25, 0.5, and 0.75 mmol/kg body weight every day for 15 days. Compared with the control group, the activities of SOD, CAT, and GSH-Px in FOs treatment groups significantly (Plevels of SOD, CAT, and HO-1 in organs. Moreover, the immunoblot analysis revealed increased nuclear factor-E2-related factor (Nrf2) protein expression levels in organs and there were positive correlations between the mRNA expression of phase II detoxifying/antioxidant enzymes and the expressions of Nrf2 protein, which demonstrated FOs treatment could modulate the detoxifying/antioxidant enzymes via Nrf2 signaling. Copyright © 2014. Published by Elsevier B.V.

  19. DOE Phase II SBIR: Spectrally-Assisted Vehicle Tracking - Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Villeneuve, Pierre V. [Space Computer Corporation

    2013-02-28

    The goal of this Phase II SBIR has been to develop a prototype software package to demonstrate spectrally-aided vehicle tracking. The primary application is to show improved target vehicle tracking performance in complex environments where traditional spatial tracker systems may show reduced performance. Examples include scenarios where the target vehicle is obscured by a large structure for an extended period of time, or where the target is engaging in extreme maneuvers amongst other civilian vehicles. The target information derived from spatial processing is unable to differentiate between the green versus the red vehicle. Spectral signature exploitation enables comparison of new candidate targets with existing track signatures. The ambiguity in this confusing scenario is resolved by folding spectral analysis results into each target nomination and association processes. The work performed over the two-year effort was divided into three general areas: algorithm refinement, software prototype development, and prototype performance demonstration. The tasks performed under this Phase II resulted in the completion of a software tool suitable for evaluation and testing of advanced tracking concepts.

  20. BOP2: Bayesian optimal design for phase II clinical trials with simple and complex endpoints.

    Science.gov (United States)

    Zhou, Heng; Lee, J Jack; Yuan, Ying

    2017-09-20

    We propose a flexible Bayesian optimal phase II (BOP2) design that is capable of handling simple (e.g., binary) and complicated (e.g., ordinal, nested, and co-primary) endpoints under a unified framework. We use a Dirichlet-multinomial model to accommodate different types of endpoints. At each interim, the go/no-go decision is made by evaluating a set of posterior probabilities of the events of interest, which is optimized to maximize power or minimize the number of patients under the null hypothesis. Unlike other existing Bayesian designs, the BOP2 design explicitly controls the type I error rate, thereby bridging the gap between Bayesian designs and frequentist designs. In addition, the stopping boundary of the BOP2 design can be enumerated prior to the onset of the trial. These features make the BOP2 design accessible to a wide range of users and regulatory agencies and particularly easy to implement in practice. Simulation studies show that the BOP2 design has favorable operating characteristics with higher power and lower risk of incorrectly terminating the trial than some existing Bayesian phase II designs. The software to implement the BOP2 design is freely available at www.trialdesign.org. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  1. Phase II enzyme induction by a carotenoid, lutein, in a PC12D neuronal cell line

    Energy Technology Data Exchange (ETDEWEB)

    Miyake, Seiji [Laboratory of Retinal Cell Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582 (Japan); Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582 (Japan); Wakasa Seikatsu Co., Ltd., 134 Chudoujiminami-cho, Shimogyo-ku, Kyoto 600-8813 (Japan); Kobayashi, Saori [Wakasa Seikatsu Co., Ltd., 134 Chudoujiminami-cho, Shimogyo-ku, Kyoto 600-8813 (Japan); Tsubota, Kazuo [Laboratory of Retinal Cell Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582 (Japan); Ozawa, Yoko, E-mail: ozawa@a5.keio.jp [Laboratory of Retinal Cell Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582 (Japan); Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582 (Japan)

    2014-04-04

    Highlights: • Lutein reduced ROS levels in a PC12D neuronal cell line. • Lutein induced mRNAs of phase II antioxidative enzymes in PC12D neuronal cells. • Lutein increased protein levels of HO-1, SOD2, and NQO-1 in PC12D neuronal cells. • Lutein had no effect on intranuclear Nrf2 levels in PC12D neuronal cells. • Lutein did not activate potential upstream Nrf2 nuclear translocation pathways. - Abstract: The mechanism by which lutein, a carotenoid, acts as an antioxidant in retinal cells is still not fully understood. Here, lutein treatment of a neuronal cell line (PC12D) immediately resulted in reduced intracellular ROS levels, implying that it has a direct role in ROS scavenging. Significantly, lutein treatment also induced phase II antioxidative enzyme expression, probably via a nuclear factor-like 2 (Nrf2) independent pathway. This latter mechanism could explain why lutein acts diversely to protect against oxidative/cytotoxic stress, and why it is physiologically involved in the human neural tissue, such as the retina.

  2. Study of the transverse beam motion in the DARHT Phase II accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Yu-Jiuan; Fawley, W M; Houck, T L

    1998-08-20

    The accelerator for the second-axis of the Dual Axis Radiographic Hydrodynamic Test (DARHT) facility will accelerate a 4-kA, 3-MeV, 2--µs long electron current pulse to 20 MeV. The energy variation of the beam within the flat-top portion of the current pulse is (plus or equal to) 0.5%. The performance of the DARHT Phase II radiographic machine requires the transverse beam motion to be much less than the beam spot size which is about 1.5 mm diameter on the x-ray converter. In general, the leading causes of the transverse beam motion in an accelerator are the beam breakup instability (BBU) and the corkscrew motion. We have modeled the transverse beam motion in the DARHT Phase II accelerator with various magnetic tunes and accelerator cell configurations by using the BREAKUP code. The predicted sensitivity of corkscrew motion and BBU growth to different tuning algorithms will be presented.

  3. The sROD Module for the ATLAS Tile Calorimeter Phase-II Upgrade Demonstrator

    CERN Document Server

    Carrio, F; Ferrer, A; Fiorini, L; Hernandez, Y; Higon, E; Mellado, B; March, L; Moreno, P; Reed, R; Solans, C; Valero, A; Valls, J A

    2014-01-01

    TileCal is the central hadronic calorimeter of the ATLAS experiment at the Large Hadron Collider (LHC) at CERN. The main upgrade of the LHC to increase the instantaneous luminosity is scheduled for 2022. The High Luminosity LHC, also called upgrade Phase-II, will imply a complete redesign of the read-out electronics in TileCal. In the new read-out architecture, the front-end electronics aims to transmit full digitized information to the back-end system in the counting rooms. Thus, the back-end system will provide digital calibrated information with en- hanced precision and granularity to the first level trigger to improve the trigger efficiencies. The demonstrator project is envisaged to qualify this new proposed architecture. A reduced part of the detector, 1/256 of the total, will be upgraded with the new electronics during 2014 to evaluate the proposed architecture in real conditions. The upgraded Read-Out Driver (sROD) will be the core element of the back-end electronics in Phase-II The sROD module is des...

  4. Research and Development for the ATLAS Forward Calorimetry at the Phase-II LHC

    CERN Document Server

    Cheplakov, Alexander; The ATLAS collaboration

    2015-01-01

    During the LHC Run-1 data taking period the ATLAS calorimeter system demonstrated an excellent performance of the electron and photon reconstruction as well as the hadronic jets and missing transverse energy measurements. These precision measurements played a major role in the discovery of the Higgs boson. Further study of the Higgs properties and SUSY searches should be performed at Phase-II LHC which will run at 5-7 times higher luminosity aiming to provide statistics of 3000fb-1 by 2037. A total irradiation doses will be more than doubled compared to the original design, taking into account a safety factor of 2 representing our confidence in radiation background simulations. Moreover, the increased instantaneous luminosity will result in a much higher detector occupancy. The ATLAS Forward Calorimeters (FCal) will be affected by these factors. A rich R&D program is ongoing to evaluate the consequences of the LHC modernization and to investigate different scenarios proposed for the Phase-II detector upgr...

  5. ICFT: An initial closed-loop flow test of the Fenton Hill Phase II HDR reservoir

    Energy Technology Data Exchange (ETDEWEB)

    Dash, Z.V. (ed.); Aguilar, R.G.; Dennis, B.R.; Dreesen, D.S.; Fehler, M.C.; Hendron, R.H.; House, L.S.; Ito, H.; Kelkar, S.M.; Malzahn, M.V.

    1989-02-01

    A 30-day closed-loop circulation test of the Phase II Hot Dry Rock reservoir at Fenton Hill, New Mexico, was conducted to determine the thermal, hydraulic, chemical, and seismic characteristics of the reservoir in preparation for a long-term energy-extraction test. The Phase II heat-extraction loop was successfully tested with the injection of 37,000 m/sup 3/ of cold water and production of 23,300 m/sup 3/ of hot water. Up to 10 MW/sub t/ was extracted when the production flow rate reached 0.0139 m/sup 3//s at 192/degree/C. By the end of the test, the water-loss rate had decreased to 26% and a significant portion of the injected water was recovered; 66% during the test and an additional 20% during subsequent venting. Analysis of thermal, hydraulic, geochemical, tracer, and seismic data suggests the fractured volume of the reservoir was growing throughout the test. 19 refs., 64 figs., 19 tabs.

  6. Sagittarius II, Draco II and Laevens 3: three new Milky Way satellites discovered in the Pan-STARRS 1 3pi Survey

    CERN Document Server

    Laevens, Benjamin P M; Bernard, Edouard J; Schlafly, Edward F; Sesar, Branimir; Rix, Hans-Walter; Bell, Eric F; Ferguson, Annette M N; Slater, Colin T; Sweeney, William E; Wyse, Rosemary F G; Huxor, Avon P; Burgett, William S; Chambers, Kenneth C; Draper, Peter W; Magnier, Eugene A; Metcalfe, Nigel; Tonry, John L; Wainscoat, Richard J; Waters, Christopher

    2015-01-01

    We present the discovery of three new Milky Way satellites from our search for compact stellar overdensities in the photometric catalog of the Panoramic Survey Telescope and Rapid Response System 1 (Pan-STARRS 1, or PS1) 3pi survey. The first satellite, Laevens 3, is located at a heliocentric distance of d=67+/-3 kpc. With a total magnitude of Mv=-4.4+/-0.3 and a half-light radius rh=7+/-2 pc, its properties resemble those of outer halo globular clusters. The second system, Draco II/Laevens 4 (Dra II), is a closer and fainter satellite (d~20 kpc, Mv =-2.9+/-0.8), whose uncertain size (rh = 19 +8/-6 pc) renders its classification difficult without kinematic information; it could either be a faint and extended globular cluster or a faint and compact dwarf galaxy. The third satellite, Sagittarius II/Laevens 5 (Sgr II), has an ambiguous nature as it is either the most compact dwarf galaxy or the most extended globular cluster in its luminosity range (rh = 37 +9/-8 pc and Mv=-5.2+/-0.4). At a heliocentric distance...

  7. 77 FR 23228 - Notice of Submission for OMB Review; Small Business Innovation Research (SBIR) Program-Phase II...

    Science.gov (United States)

    2012-04-18

    ... Public Law 106-554, the ``Small Business Reauthorization Act of 2000, H.R. 5667'' enacted on December 21... Notice of Submission for OMB Review; Small Business Innovation Research (SBIR) Program--Phase II--Grant Application Package SUMMARY: This application package invites small business concerns to submit a Phase...

  8. Climatepipes: User-friendly data access, data manipulation, data analysis and visualization of community climate models Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Chaudhary, Aashish [Kitware, Inc., Clifton Park, NY (United States)

    2015-09-02

    In Phase I, we successfully developed a web-based tool that provides workflow and form-based interfaces for accessing, querying, and visualizing interesting datasets from one or more sources. For Phase II of the project, we have implemented mechanisms for supporting more elaborate and relevant queries.

  9. A Quadruple-Phase Strong Mg II Absorber at z~0.9902 Toward PG 1634+706

    CERN Document Server

    Ding, J; Bond, N A; Zonak, S G; Churchill, C W

    2003-01-01

    The z=0.9902 system along the quasar PG 1634+706 line of sight is a strong MgII absorber (W(2796)>0.3A) with only weak CIV absorption (it is ``CIV-deficient''). To study this system, we used high-resolution spectra from both HST/STIS (R=30,000) and Keck/HIRES (R=45,000). These spectra cover key transitions, such as MgI, MgII, FeII, SiII, CII, SiIII, CIII, SiIV, and CIV. Assuming a Haardt and Madau extragalactic background spectrum, we modeled the system with a combination of photoionization and collisional ionization. Based on a comparison of synthetic spectra to the data profiles, we infer the existence of the following four phases of gas: i) Seven MgII clouds have sizes of 1-1000pc and densities of 0.002-0.1/cm^3, with a gradual decrease in density from blue to red. The MgII phase gives rise to most of the CIV absorption and resembles the warm, ionized inter-cloud medium of the Milky Way; ii) Instead of arising in the same phase as MgII, MgI is produced in separate, narrow components with b~0.75km/s. These ...

  10. SU-E-J-35: Clinical Performance Evaluation of a Phase II Proton CT Scanner

    Energy Technology Data Exchange (ETDEWEB)

    Mandapaka, A; Ghebremedhin, A; Farley, D; Giacometti, V; Vence, N; Bashkirov, V; Patyal, B; Schulte, R [Loma Linda UniversityMedical Center, Loma Linda, CA (United States); Plautz, T; Zatserklyaniy, A; Johnson, R; Sadrozinski, H [University of California Santa Cruz, Santa Cruz, CA (United States)

    2014-06-01

    Purpose: To develop the methodology to evaluate the clinical performance of a Phase II Proton CT scanner Methods: Range errors on the order of 3%-5% constitute a major uncertainty in current charged particle treatment planning based on Hounsfield Unit (HU)-relative stopping power (RSP) calibration curves. Within our proton CT collaboration, we previously developed and built a Phase I proton CT scanner that provided a sensitive area of 9 cm (axial) × 18 cm (in-plane). This scanner served to get initial experience with this new treatment planning tool and to incorporate lessons learned into the next generation design. A Phase II scanner was recently completed and is now undergoing initial performance testing. It will increase the proton acquisition rate and provide a larger detection area of 9 cm x 36 cm. We are now designing a comprehensive evaluation program to test the image quality, imaging dose, and range uncertainty associated with this scanner. The testing will be performed along the lines of AAPM TG 66. Results: In our discussion of the evaluation protocol we identified the following priorities. The image quality of proton CT images, in particular spatial resolution and low-density contrast discrimination, will be evaluated with the Catphan600 phantom. Initial testing showed that the Catphan uniformity phantom did not provide sufficient uniformity; it was thus replaced by a cylindrical water phantom. The imaging dose will be tested with a Catphan dose module, and compared to a typical cone beam CT dose for comparable image quality. Lastly, we developed a dedicated dosimetry range phantom based on the CIRS pediatric head phantom HN715. Conclusion: A formal evaluation of proton CT as a new tool for proton treatment planning is an important task. The availability of the new Phase II proton CT scanner will allow us to perform this task. This research is supported by the National Institute of Biomedical Imaging and Bioengineering of the NIH under award number R01

  11. Robust growth of avirulent phase II Coxiella burnetii in bone marrow-derived murine macrophages

    Science.gov (United States)

    Cockrell, Diane C.; Long, Carrie M.; Robertson, Shelly J.; Shannon, Jeffrey G.; Miller, Heather E.; Myers, Lara; Larson, Charles L.; Starr, Tregei; Beare, Paul A.

    2017-01-01

    Published data show that murine bone marrow-derived macrophages (BMDM) restrict growth of avirulent phase II, but not virulent phase I, Coxiella burnetii. Growth restriction of phase II bacteria is thought to result from potentiated recognition of pathogen-associated molecular patterns, which leads to production of inhibitory effector molecules. Past studies have used conditioned medium from L-929 murine fibroblasts as a source of macrophage-colony stimulating factor (M-CSF) to promote differentiation of bone marrow-derived myeloid precursors into macrophages. However, uncharacterized components of conditioned medium, such as variable amounts of type I interferons, can affect macrophage activation status and their permissiveness for infection. In the current study, we show that the C. burnetii Nine Mile phase II (NMII) strain grows robustly in primary macrophages from C57BL/6J mice when bone marrow cells are differentiated with recombinant murine M-CSF (rmM-CSF). Bacteria were readily internalized by BMDM, and replicated within degradative, LAMP1-positive vacuoles to achieve roughly 3 logs of growth over 6 days. Uninfected BMDM did not appreciably express CD38 or Egr2, markers of classically (M1) and alternatively (M2) activated macrophages, respectively, nor did infection change the lack of polarization. In accordance with an M0 phenotype, infected BMDM produced moderate amounts of TNF and nitric oxide. Similar NMII growth results were obtained using C57BL/6J myeloid progenitors immortalized with an estrogen-regulated Hoxb8 (ER-Hoxb8) oncogene. To demonstrate the utility of the ER-Hoxb8 system, myeloid progenitors from natural resistance-associated macrophage protein 1 (Nramp1) C57BL/6J knock-in mice were transduced with ER-Hoxb8, and macrophages were derived from immortalized progenitors using rmM-CSF and infected with NMII. No difference in growth was observed when compared to macrophages from wild type mice, indicating depletion of metal ions by the Nramp1

  12. An Evaluation of Incentive Experiments in a Two-Phase Address-Based Sample Mail Survey

    Directory of Open Access Journals (Sweden)

    Daifeng Han

    2013-12-01

    Full Text Available Address-based sampling (ABS with a two-phase data collection approach has emerged as a promising alternative to random digit dial (RDD surveys for studying specific subpopulations in the United States. In 2011, the National Household Education Surveys Program Field Test used a two-phase ABS design with a postal or mail screener to identify households with eligible children and a mail topical questionnaire administered to parents of sampled children to collect measures of interest. Experiments with prepaid cash incentives and special mail delivery methods were applied in both phases. For the screener, sampled addresses were randomly designated to receive either $2 or $5 in the initial mailing. During the topical phase, incentives (ranging from $0 to $20 and delivery methods (First Class Mail or Priority Mail were assigned randomly but depended on how quickly the household had responded to the screener. The paper first evaluates the effects of incentives on response rates, and then examines incentive levels for attracting the hard-to-reach groups and improving sample composition. The impact of incentive on data collection cost is also examined.

  13. ADVANCED SIMULATION CAPABILITY FOR ENVIRONMENTAL MANAGEMENT- CURRENT STATUS AND PHASE II DEMONSTRATION RESULTS

    Energy Technology Data Exchange (ETDEWEB)

    Seitz, R.

    2013-02-26

    The U.S. Department of Energy (USDOE) Office of Environmental Management (EM), Office of Soil and Groundwater, is supporting development of the Advanced Simulation Capability for Environmental Management (ASCEM). ASCEM is a state-of-the-art scientific tool and approach for understanding and predicting contaminant fate and transport in natural and engineered systems. The modular and open source high-performance computing tool facilitates integrated approaches to modeling and site characterization that enable robust and standardized assessments of performance and risk for EM cleanup and closure activities. The ASCEM project continues to make significant progress in development of computer software capabilities with an emphasis on integration of capabilities in FY12. Capability development is occurring for both the Platform and Integrated Toolsets and High-Performance Computing (HPC) Multiprocess Simulator. The Platform capabilities provide the user interface and tools for end-to-end model development, starting with definition of the conceptual model, management of data for model input, model calibration and uncertainty analysis, and processing of model output, including visualization. The HPC capabilities target increased functionality of process model representations, toolsets for interaction with Platform, and verification and model confidence testing. The Platform and HPC capabilities are being tested and evaluated for EM applications in a set of demonstrations as part of Site Applications Thrust Area activities. The Phase I demonstration focusing on individual capabilities of the initial toolsets was completed in 2010. The Phase II demonstration completed in 2012 focused on showcasing integrated ASCEM capabilities. For Phase II, the Hanford Site deep vadose zone (BC Cribs) served as an application site for an end-to-end demonstration of capabilities, with emphasis on integration and linkages between the Platform and HPC components. Other demonstrations

  14. Solid phase extraction of Cu(II), Ni(II), Pb(II), Cd(II) and Mn(II) ions with 1-(2-thiazolylazo)-2-naphthol loaded Amberlite XAD-1180.

    Science.gov (United States)

    Tokalioğlu, Serife; Yilmaz, Vedat; Kartal, Senol

    2009-05-01

    A new method for separation and preconcentration of trace amounts of Cu(II), Ni(II), Pb(II), Cd(II) and Mn(II) ions in various matrices was proposed. The method is based on the adsorption and chelation of the metal ions on a column containing Amberlite XAD-1180 resin impregnated with 1-(2-thiazolylazo)-2-naphthol (TAN) reagent prior to their determination by flame atomic absorption spectrometry (FAAS). The effect of pH, type, concentration and volume of eluent, sample volume, flow rates of sample and elution solutions, and interfering ions have been investigated. The optimum pH for simultaneous retention of all the metal ions was 9. Eluent for quantitative elution was 20 ml of 2 mol l(-1) HNO(3). The optimum sample and eluent flow rates were found as 4 ml min(-1), and also sample volume was 500 ml, except for Mn (87% recovery). The sorption capacity of the resin was found to be 0.77, 0.41, 0.57, and 0.30 mg g(-1) for Cu(II), Ni(II), Cd(II), and Mn(II), respectively. The preconcentration factor of the method was 200 for Cu(II), 150 for Pb(II), 100 for Cd(II) and Ni(II), and 50 for Mn(II). The recovery values for all of the metal ions were > or = 95% and relative standard deviations (RSDs) were < or = 5.1%. The detection limit values were in the range of 0.03 and 1.19 microg l(-1). The accuracy of the method was confirmed by analysing the certified reference materials (TMDA 54.4 fortified lake water and GBW 07605 tea samples) and the recovery studies. This procedure was applied to the determination of Cu(II), Ni(II), Pb(II), Cd(II) and Mn(II) in waste water and lake water samples.

  15. The Effect of Host Galaxies on Type Ia Supernovae in the SDSS-II Supernova Survey

    CERN Document Server

    Lampeitl, Hubert; Nichol, Robert C; Bassett, Bruce; Cinabro, David; Dilday, Benjamin; Foley, Ryan J; Frieman, Joshua A; Garnavich, Peter M; Goobar, Ariel; Im, Myungshin; Jha, Saurabh W; Marriner, John; Miquel, Ramon; Nordin, Jakob; Östman, Linda; Riess, Adam G; Sako, Masao; Schneider, Donald P; Sollerman, Jesper; Stritzinger, Maximilian

    2010-01-01

    We present an analysis of the host galaxy dependencies of Type Ia Supernovae (SNe Ia) from the full three year sample of the SDSS-II Supernova Survey. We rediscover, to high significance, the strong correlation between host galaxy typeand the width of the observed SN light curve, i.e., fainter, quickly declining SNe Ia favor passive host galaxies, while brighter, slowly declining Ia's favor star-forming galaxies. We also find evidence (at between 2 to 3 sigma) that SNe Ia are ~0.1 magnitudes brighter in passive host galaxies, than in star-forming hosts, after the SN Ia light curves have been standardized using the light curve shape and color variations: This difference in brightness is present in both the SALT2 and MCLS2k2 light curve fitting methodologies. We see evidence for differences in the SN Ia color relationship between passive and star-forming host galaxies, e.g., for the MLCS2k2 technique, we see that SNe Ia in passive hosts favor a dust law of R_V ~1, while SNe Ia in star-forming hosts require R_V ...

  16. Survey of non-linear hydrodynamic models of type-II Cepheids

    CERN Document Server

    Smolec, R

    2015-01-01

    We present a grid on non-linear convective type-II Cepheid models. The dense model grids are computed for 0.6M_Sun and a range of metallicities ([Fe/H]=-2.0,-1.5,-1.0), and for 0.8M_Sun ([Fe/H]=-1.5). Two sets of convective parameters are considered. The models cover the full temperature extent of the classical instability strip, but are limited in luminosity; for the most luminous models violent pulsation leads to the decoupling of the outermost model shell. Hence, our survey reaches only the shortest period RV Tau domain. In the Hertzsprung-Russel diagram we detect two domains in which period doubled pulsation is possible. The first extends through the BL Her domain and low luminosity W Vir domain (pulsation periods ~2-6.5 d). The second domain extends at higher luminosities (W Vir domain; periods >9.5d). Some models within these domains display period-4 pulsation. We also detect very narrow domains (~10 K wide) in which modulation of pulsation is possible. Another interesting phenomenon we detect is double...

  17. CALIFA, the Calar Alto Legacy Integral Field Area survey: II. First public data release

    CERN Document Server

    Husemann, B; Sánchez, S F; Barrado-Navascues, D; Bekeraitė, S; Bomans, D J; Castillo-Morales, A; Catalán-Torrecilla, C; Fernandes, R Cid; Falcón-Barroso, J; García-Benito, R; Delgado, R M González; Iglesias-Páramo, J; Johnson, B D; Kupko, D; López-Fernandez, R; Lyubenova, M; Marino, R A; Mast, D; Miskolczi, A; Monreal-Ibero, A; de Paz, A Gil; Pérez, E; Pérez, I; Rosales-Ortega, F F; Ruiz-Lara, T; Schilling, U; van de Ven, G; Walcher, J; Alves, J; de Amorim, A L; Backsmann, N; Barrera-Ballesteros, J K; Bland-Hawthorn, J; Dettmar, R -J; Demleitner, M; Díaz, A I; Enke, H; Florido, E; Flores, H; Galbany, L; Gallazzi, A; García-Lorenzo, B; Gomes, J M; Gruel, N; Haines, T; Holmes, L; Jungwiert, B; Kalinova, V; Kehrig, C; Kennicutt, R C; Klar, J; Lehnert, M D; Lóez-Sáchez, Á R; de Lorenzo-Cáceres, A; Mármol-Queraltó, E; Márquez, I; Mendez-Abreu, J; Mollá, M; del Olmo, A; Meidt, S E; Papaderos, P; Puschnig, J; Quirrenbach, A; Roth, M M; Sánchez-Blázquez, P; Spekkens, K; Singh, R; Stanishev, V; Trager, S C; Vilchez, J M; Wild, V; Wisotzki, L; Zibetti, S; Ziegler, B

    2012-01-01

    We present the first public data release of the CALIFA survey. It consists of science-grade optical datacubes for the first 100 of eventually 600 nearby (0.005ii) a medium-resolution V1200 setup covering the nominal wavelength range 3650-4840A with a spectral resolution of 2.3A (FWHM). We present the characteristics and data structure of the CALIFA datasets that should be taken into account for scientific exploita...

  18. Membrane/distillation hybrid process research and development. Final report, phase II

    Energy Technology Data Exchange (ETDEWEB)

    Mazanec, T.J.

    1997-07-01

    This report covers work conducted under the grant awarded to BP by DOE in late 1991 entitled {open_quotes}Membrane/Distillation Hybrid Process Research and Development.{close_quotes} The program was directed towards development and commercialization of the BP process for separation of vapor phase olefins from non-olefins via facilitated transport using an aqueous facilitator. The program has come to a very successful conclusion, with formation of a partnership between BP and Stone and Webster Engineering Corporation (SWEC) to market and commercialize the technology. The focus of this report is the final portion of the program, during which engineering re-design, facilitator optimization, economic analysis, and marketing have been the primary activities. At the end of Phase II BP was looking to partner with an engineering firm to advance the selective olefin recovery (SOR) technology from the lab/demo stage to full commercialization. In August 1995 BP and SWEC reached an agreement to advance the technology by completing additional Phase III work with DOE and beginning marketing activities.

  19. Phase II Water Rental Pilot Project: Snake River Resident Fish and Wildlife Resources and Management Recommendations.

    Energy Technology Data Exchange (ETDEWEB)

    Stovall, Stacey H.

    1994-08-01

    The Idaho Water Rental Pilot Project was implemented in 1991 as part of the Non-Treaty Storage Fish and Wildlife Agreement between Bonneville Power Administration and the Columbia Basin Fish and Wildlife Authority. The goal of the project is to quantify resident fish and wildlife impacts resulting from salmon flow augmentation releases made from the upper Snake River Basin. Phase I summarized existing resource information and provided management recommendations to protect and enhance resident fish and wildlife habitat resulting from storage releases for the I improvement of an adromous fish migration. Phase II includes the following: (1) a summary of recent biological, legal, and political developments within the basin as they relate to water management issues, (2) a biological appraisal of the Snake River between American Falls Reservoir and the city of Blackfoot to examine the effects of flow fluctuation on fish and wildlife habitat, and (3) a preliminary accounting of 1993--1994 flow augmentation releases out of the upper Snake, Boise, and Payette river systems. Phase III will include the development of a model in which annual flow requests and resident fish and wildlife suitability information are interfaced with habitat time series analysis to provide an estimate of resident fish and wildlife resources.

  20. Phenotype prediction of nonsynonymous single nucleotide polymorphisms in human phase II drug/xenobiotic metabolizing enzymes: perspectives on molecular evolution

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Nonsynonymous single nucleotide polymorphisms (nsSNPs) in coding regions can lead to amino acid changes that might alter the protein’s function and account for susceptibility to disease and altered drug/xenobiotic response. Many nsSNPs have been found in genes encoding human phase II metabolizing enzymes; however, there is little known about the relationship between the genotype and phenotype of nsSNPs in these enzymes. We have identified 923 validated nsSNPs in 104 human phase II enzyme genes from the Ensembl genome database and the NCBI SNP database. Using PolyPhen, Panther, and SNAP algorithms, 44%?59% of nsSNPs in phase II enzyme genes were predicted to have functional impacts on protein function. Predictions largely agree with the available experimental annotations. 68% of deleterious nsSNPs were correctly predicted as damaging. This study also identified many amino acids that are likely to be functionally critical, but have not yet been studied experimentally. There was significant concordance between the predicted results of Panther and PolyPhen, and between SNAP non-neutral predictions and PolyPhen scores. Evolutionarily non-neutral (destabilizing) amino acid substitutions are thought to be the pathogenetic basis for the alteration of phase II enzyme activity and to be associated with disease susceptibility and drug/xenobiotic toxicity. Furthermore, the molecular evolutionary patterns of phase II enzymes were characterized with regards to the predicted deleterious nsSNPs.

  1. Characterization, phase change and conductivity crossover of new luminescent ferroelectric Mn (II) organic-inorganic hybrid

    Energy Technology Data Exchange (ETDEWEB)

    Mostafa, Mohga F., E-mail: Mohga40@yahoo.com; El Dean, Thana Sh., E-mail: th_sh2000@yahoo.com; Tammam, Ahmed K., E-mail: physicsoman@yahoo.com

    2016-09-01

    Synthesis and characterization of new luminescent ferroelectric [(CH{sub 3})(C{sub 6}H{sub 5}){sub 3}P]{sub 2}MnBr{sub 4} organic-inorganic hybrid (OIH) are reported. Powder x-ray diffraction showed the following phases: {sup P2/m} {sup (280 K)} Phase (IV) {sup P21} {sup (298 K)} Phase (III) {sup Pna21} {sup (350 K)} Phase (II) {sup Pnma} {sup (370 K)} Phase (I). Room temperature lattice parameters are a = 9.6233 (Å), b = 12.5653 (Å) c = 16.4503 (Å) and β = 105.6° (T = 298 K). UV-VIS and Ac magnetic susceptibility confirm tetrahedral symmetry of [MnBr{sub 4}]{sup 2−}. DSC and dielectric measurements showed four phase transitions at T{sub 4peak} = 279.1 ± 1 K (ΔS = 1.03 J/mol K), T{sub 3peak} = 300.1 ± 2 K (ΔS = 2.33 J/mol K), T{sub 2peakt} = 353.2 ± 3 K (ΔS = 2.68 J/mol K) and T{sub 1peak} = 379.1 ± 3 K (ΔS = 2.43 J/mol K). Calculated lattice potential energy values vary from 827 (kJ/mol) at 280 K to (797 kJ/mol) at 370 K. Ac conductivity measurements (220 < T(K) < 400) and (0.081 < f (kHz) < 30) are presented. It is ferroelectric with Curie temperature T{sub c} = 309 K. Hybrid is semiconductor in the temperature range 309 ± 14 K, where conductivity follows Jonscher’s universal dielectric response otherwise it is an insulator where crossover to super-linear power law prevails. Comparison to the corresponding chloride is discussed. - Graphical abstract: Plot of real part of permittivity [ln(ε′)] versus temperature (K). - Highlights: • Conductivity crossover from SlPL to UDR is confirmed. • Change from semiconductor to insulator. • Structural phase transformation.

  2. The 1992 Pacific Northwest Residential Energy Survey: Phase 1 : Book 1 : Getting Started.

    Energy Technology Data Exchange (ETDEWEB)

    Applied Management & Planning Group (firm); United States. Bonneville Power Administration. End-Use Research Section.

    1993-08-01

    This Executive Summary outlines the general processes employed in and the major findings from the conduct of Phase I of the Pacific Northwest Residential Energy Survey (PNWRES92-I) during the last quarter of 1992. This study was Bonneville`s third comprehensive residential survey of the region, conducted to provide data on energy usage, conservation awareness and behaviors, and associated consumer characteristics for use in forecasting and planning. The summary is divided into four sections: Background sets the stage with respect to the need for the survey, relates it to previous work, outlines the implementation processes, and summarizes the data products. Profiling the respondents summarizes the survey results under these six categories: Demographics; Housing Units; Room Inventory; Appliance Inventory; Air-Conditioning/Heating; Water-Heating; and Opinion. Reports and cross-tabulations describes the various individual documents. Bonneville Power Plus provides a short description of an Excel-spreadsheet-based software program that contains all of the tabulated material in a format that encourages browsing among the tables and charts, with special feature that they can be copied directly into other Windows-based documents.

  3. The 1992 Pacific Northwest Residential Energy Survey : Phase 1 (PNWRES92-I) : Executive Summary, Concordance, Glossary.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration. End-Use Research Section; Applied Management & Planning Group (Firm)

    1993-08-01

    The general processes employed in and the major findings from the conduct of Phase I of the Pacific Northwest Residential Energy Survey (PNWRES92-I) during the last quarter of 1992 are outlined. This was Bonneville's third comprehensive residential survey of the region, conducted to provide data on energy usage, conservation awareness and behaviors, and associated consumer characteristics for use in forecasting and planning. The summary is divided into four sections: Background sets the stage with respect to the need for the survey, relates it to previous work, outlines the implementation processes, and summarizes the data products. Profiling the respondents summarizes the survey results under these six categories: Demographics, Housing Units, Room Inventory, Appliance Inventory, Air-Conditioning/Heating/Water-Heating, and Opinion. Reports and Cross-tabulations describes the various individual documents. Bonneville Power Pulse provides a short description of an Excel-spreadsheet-based software program that contains all of the tabulated material in a format that encourages browsing among the tables and charts, with special feature that they can be copied directly into other Windows-based documents.

  4. Neutron background signal in superheated droplet detectors of the Phase II SIMPLE dark matter search

    CERN Document Server

    Fernandes, A C; Felizardo, M; Girard, T A; Ramos, A R; Marques, J G; Prudêncio, M I; Marques, R; Carvalho, F P; Lázaro, I

    2015-01-01

    The simulation of the neutron background for Phase II of the SIMPLE direct dark matter search experiment is described, including further improvements relatively to previously reported data. Spontaneous fission and decay-induced (\\alpha,n) reactions originating in $^{238}$U and $^{232}$Th naturally present in the experiment materials were considered. The model employs the Monte Carlo MCNP neutron transport code, using a realistic geometry description and measured radioassays and material compositions as input. Tabled (\\alpha,n) yields, measured detection efficiencies and evaluated cross section data were used. The energy distribution of the recoiling nuclei is dealt with a distinct code. A thorough uncertainty analysis of the simulated results is performed that addresses statistical and most non-statistical uncertainties. The estimated recoil event rate is 0.367 $\\pm$ 0.002(stat.) $\\pm$ 0.064 (non-stat.) evt/kgd, a 10$\\%$ increase in the previous reported result.

  5. Edge-mounting locking mechanics for barrel strip staves for the ATLAS phase II upgrade

    CERN Document Server

    The ATLAS collaboration

    2014-01-01

    This report describes the development of an edge-mounting mechanism for the interface between a stave and its support cylinder for the barrel strip staves of the phase II ATLAS upgrade. As a direct product of the prototyping programme undertaken, we have also developed the tooling required to precisely mount the components of the mechanism to their respective structures. The design has been conceived to be compatible with tilt angles as low as 10° for the nominal module envelope, and meet the positioning and stability requirements whilst having an acceptably small contribution to the total material in the tracker volume. In order to reach these goals, the tooling for stave insertion was designed to be completely removable and respects the clearances of pre-installed staves.

  6. Phase transitions in Group III-V and II-VI semiconductors at high pressure

    Science.gov (United States)

    Yu, S. C.; Liu, C. Y.; Spain, I. L.; Skelton, E. F.

    1979-01-01

    The structures and transition pressures of Group III-V and II-VI semiconductors and of a pseudobinary system (Ga/x/In/1-x/Sb) have been investigated. Results indicate that GaP, InSb, GaSb, GaAs and possible AlP assume Metallic structures at high pressures; a tetragonal, beta-Sn-like structure is adopted by only InSb and GaSb. The rocksalt phase is preferred in InP, InAs, AlSb, ZnO and ZnS. The model of Van Vechten (1973) gives transition pressures which are in good agreement with measured values, but must be refined to account for the occurrence of the ionic rocksalt structure in some compounds. In addition, discrepancies between the theoretical scaling values for volume changes at the semiconductor-to-metal transitions are observed.

  7. Near-Term Electric Vehicle Program. Phase II: Mid-Term Summary Report.

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-08-01

    The Near Term Electric Vehicle (NTEV) Program is a constituent elements of the overall national Electric and Hybrid Vehicle Program that is being implemented by the Department of Energy in accordance with the requirements of the Electric and Hybrid Vehicle Research, Development, and Demonstration Act of 1976. Phase II of the NTEV Program is focused on the detailed design and development, of complete electric integrated test vehicles that incorporate current and near-term technology, and meet specified DOE objectives. The activities described in this Mid-Term Summary Report are being carried out by two contractor teams. The prime contractors for these contractor teams are the General Electric Company and the Garrett Corporation. This report is divided into two discrete parts. Part 1 describes the progress of the General Electric team and Part 2 describes the progress of the Garrett team.

  8. Dark-photon search using data from CRESST-II Phase 2

    Energy Technology Data Exchange (ETDEWEB)

    Angloher, G.; Bauer, P.; Iachellini, N.F.; Hauff, D.; Kiefer, M.; Mancuso, M.; Petricca, F.; Proebst, F.; Seidel, W.; Stodolsky, L.; Strauss, R.; Tanzke, A.; Wuestrich, M. [Max-Planck-Institut fuer Physik, Munich (Germany); Bento, A. [Max-Planck-Institut fuer Physik, Munich (Germany); Universidade de Coimbra, Departamento de Fisica, Coimbra (Portugal); Bucci, C.; Gorla, P.; Pagliarone, C. [INFN, Laboratori Nazionali del Gran Sasso, Assergi (Italy); Canonica, L. [INFN, Laboratori Nazionali del Gran Sasso, Assergi (Italy); Massachusetts Institute of Technology, Cambridge, MA (United States); Defay, X.; Feilitzsch, F. v.; Lanfranchi, J.C.; Muenster, A.; Potzel, W.; Schoenert, S.; Thi, H.H.T.; Ulrich, A.; Wawoczny, S.; Willers, M.; Zoeller, A. [Technische Universitaet Muenchen, Physik-Department and Excellence Cluster Universe, Garching (Germany); Erb, A. [Technische Universitaet Muenchen, Physik-Department and Excellence Cluster Universe, Garching (Germany); Walther-Meissner-Institut fuer Tieftemperaturforschung, Garching (Germany); Guetlein, A.; Kluck, H.; Puig, R.; Schieck, J.; Tuerkoglu, C. [Institut fuer Hochenergiephysik der Oesterreichischen Akademie der Wissenschaften, Vienna (Austria); Atominstitut, Vienna University of Technology, Vienna (Austria); Jochum, J.; Loebell, J.; Strandhagen, C.; Uffinger, M.; Usherov, I. [Eberhard-Karls-Universitaet Tuebingen, Tuebingen (Germany); Kraus, H. [University of Oxford, Department of Physics, Oxford (United Kingdom); Reindl, F. [Max-Planck-Institut fuer Physik, Munich (Germany); INFN-Sezione di Roma, Rome (Italy); Schaeffner, K. [INFN, Laboratori Nazionali del Gran Sasso, Assergi (Italy); GSSI-Gran Sasso Science Institute, L' Aquila (Italy)

    2017-05-15

    Identifying the nature and origin of dark matter is one of the major challenges for modern astro and particle physics. Direct dark-matter searches aim at an observation of dark-matter particles interacting within detectors. The focus of several such searches is on interactions with nuclei as provided e.g. by weakly interacting massive particles. However, there is a variety of dark-matter candidates favoring interactions with electrons rather than with nuclei. One example are dark photons, i.e., long-lived vector particles with a kinetic mixing to standard-model photons. In this work we present constraints on this kinetic mixing based on data from CRESST-II Phase 2 corresponding to an exposure before cuts of 52 kg-days. These constraints improve the existing ones for dark-photon masses between 0.3 and 0.7 keV/c{sup 2}. (orig.)

  9. The phase-II ATLAS pixel tracker upgrade: layout and mechanics.

    CERN Document Server

    Sharma, Abhishek; The ATLAS collaboration

    2016-01-01

    The ATLAS experiment will upgrade its tracking detector during the Phase-II LHC shutdown, to better take advantage of the increased luminosity of the HL-LHC. The upgraded tracker will consist of silicon-strip modules surrounding a pixel detector, and will likely cover an extended eta range, perhaps as far as |eta|<4.0. A number of layout and supporting-structure options are being considered for the pixel detector, with the final choice expected to be made in early 2017. The proposed supporting structures are based on lightweight, highly-thermally-conductive carbon-based materials and are cooled by evaporative carbon dioxide. The various layouts will be described and a description of the supporting structures will be presented, along with results from testing of prototypes.

  10. Radiation Hard Silicon Particle Detectors for Phase-II LHC Trackers

    Science.gov (United States)

    Oblakowska-Mucha, A.

    2017-02-01

    The major LHC upgrade is planned after ten years of accelerator operation. It is foreseen to significantly increase the luminosity of the current machine up to 1035 cm‑2s‑1 and operate as the upcoming High Luminosity LHC (HL-LHC) . The major detectors upgrade, called the Phase-II Upgrade, is also planned, a main reason being the aging processes caused by severe particle radiation. Within the RD50 Collaboration, a large Research and Development program has been underway to develop silicon sensors with sufficient radiation tolerance for HL-LHC trackers. In this summary, several results obtained during the testing of the devices after irradiation to HL-LHC levels are presented. Among the studied structures, one can find advanced sensors types like 3D silicon detectors, High-Voltage CMOS technologies, or sensors with intrinsic gain (LGAD). Based on these results, the RD50 Collaboration gives recommendation for the silicon detectors to be used in the detector upgrade.

  11. New fuzzy EWMA control charts for monitoring phase II fuzzy profiles

    Directory of Open Access Journals (Sweden)

    Ghazale Moghadam

    2016-01-01

    Full Text Available In many quality control applications, the quality of a process or product is explained by the relationship between response variable and one or more explanatory variables, called a profile. In this paper, a new fuzzy EWMA control chart for phase II fuzzy profile monitoring is proposed. To this end, we extend EWMA control charts to its equivalent Fuzzy type and then implement fuzzy ranking methods to determine whether the process fuzzy profile is under or out of control. The proposed method is capable of identifying small changes in process under condition of process profile explaining parameters vagueness, roughness and uncertainty. Determining the source of changes, this method provides us with the possibility of recognizing the causes of process transition from stable mode, removing these causes and restoring the process stable mode.

  12. Integrated safety analysis of rolapitant with coadministered drugs from phase II/III trials

    DEFF Research Database (Denmark)

    Barbour, S; Smit, T.; Wang, X

    2017-01-01

    for treatment-emergent adverse events (TEAEs) and treatment-emergent serious adverse events (TESAEs) during cycle 1 were pooled across the four studies and summarized in the overall population and by concomitant use/non-use of CYP2D6 or BCRP substrate drugs. Results: In the integrated safety population, 828...... cytochrome P450 (CYP) 3A4, but it does inhibit CYP2D6 and breast cancer resistance protein (BCRP). To analyze potential drug-drug interactions between rolapitant and concomitant medications, this integrated safety analysis of four double-blind, randomized phase II or III studies of rolapitant examined...... the safety of rolapitant as part of an antiemetic triple-drug regimen in patients receiving emetogenic chemotherapy, including those administered concomitant medications that are substrates of CYP2D6 or BCRP, such as ondansetron, docetaxel, or irinotecan....

  13. Performance of the TilePPr demonstrator for the ATLAS Tile Calorimeter Phase II Upgrade

    CERN Document Server

    Carrio Argos, Fernando; The ATLAS collaboration

    2015-01-01

    The Tile Calorimeter Pre-processor (TilePPr) demonstrator is a high performance double AMC board based on FPGA resources and QSFP modules. This board has been designed in the framework of the ATLAS Tile Calorimeter (TileCal) Demonstrator Project for the Phase II Upgrade as the first stage of the off-detector electronics. The TilePPr demonstrator has been conceived for receiving and processing the data coming from the on-detector electronics of the TileCal Demonstrator module, as well as for configuring it. Moreover, the TilePPr demonstrator handles the communication with the Detector Control System to monitor and control the on-detector electronics.

  14. Nonisovalent Si-III-V and Si-II-VI alloys: Covalent, ionic, and mixed phases

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Joongoo; Park, Ji-Sang; Stradins, Pauls; Wei, Su-Huai

    2017-07-01

    Nonequilibrium growth of Si-III-V or Si-II-VI alloys is a promising approach to obtaining optically more active Si-based materials. We propose a new class of nonisovalent Si2AlP (or Si2ZnS) alloys in which the Al-P (or Zn-S) atomic chains are as densely packed as possible in the host Si matrix. As a hybrid of the lattice-matched parent phases, Si2AlP (or Si2ZnS) provides an ideal material system with tunable local chemical orders around Si atoms within the same composition and structural motif. Here, using first-principles hybrid functional calculations, we discuss how the local chemical orders affect the electronic and optical properties of the nonisovalent alloys.

  15. Conspray dynamic sleeve piston coal feeder. Phase II. Verification tests. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    1984-01-26

    This report details the performance of Phase II: Verification Tests of the Conspray dynamic sleeve piston coal feeder. The machine performed for 200 hours at 700 psi backpressure, utilizing a 70% to 200 mesh Utah bituminous coal as feedstock. All test work was satisfactorily completed. A post-test inspection was performed. A report of component wear and failures incurred in testing is included as well as suggestions for machine upgrades. The overall conclusion is that the dynamic sleeve piston feeder has proven its ability to operate safely and reliably. When problems have occurred, the machine has demonstrated inherent safety by shutting down without endangering process or personnel. With the recommended improvements incorporated into the feeder, the unit will be ready for installation on a pilot scale coal gasifier. 9 figures, 11 tables.

  16. The Detection of an Extremely Bright Fast Radio Burst in a Phased Array Feed Survey

    Science.gov (United States)

    Bannister, K. W.; Shannon, R. M.; Macquart, J.-P.; Flynn, C.; Edwards, P. G.; O'Neill, M.; Osłowski, S.; Bailes, M.; Zackay, B.; Clarke, N.; D'Addario, L. R.; Dodson, R.; Hall, P. J.; Jameson, A.; Jones, D.; Navarro, R.; Trinh, J. T.; Allison, J.; Anderson, C. S.; Bell, M.; Chippendale, A. P.; Collier, J. D.; Heald, G.; Heywood, I.; Hotan, A. W.; Lee-Waddell, K.; Madrid, J. P.; Marvil, J.; McConnell, D.; Popping, A.; Voronkov, M. A.; Whiting, M. T.; Allen, G. R.; Bock, D. C.-J.; Brodrick, D. P.; Cooray, F.; DeBoer, D. R.; Diamond, P. J.; Ekers, R.; Gough, R. G.; Hampson, G. A.; Harvey-Smith, L.; Hay, S. G.; Hayman, D. B.; Jackson, C. A.; Johnston, S.; Koribalski, B. S.; McClure-Griffiths, N. M.; Mirtschin, P.; Ng, A.; Norris, R. P.; Pearce, S. E.; Phillips, C. J.; Roxby, D. N.; Troup, E. R.; Westmeier, T.

    2017-05-01

    We report the detection of an ultra-bright fast radio burst (FRB) from a modest, 3.4-day pilot survey with the Australian Square Kilometre Array Pathfinder. The survey was conducted in a wide-field fly’s-eye configuration using the phased-array-feed technology deployed on the array to instantaneously observe an effective area of 160 deg2, and achieve an exposure totaling 13200 deg2 hr . We constrain the position of FRB 170107 to a region 8\\prime × 8\\prime in size (90% containment) and its fluence to be 58 ± 6 Jy ms. The spectrum of the burst shows a sharp cutoff above 1400 MHz, which could be due to either scintillation or an intrinsic feature of the burst. This confirms the existence of an ultra-bright (> 20 Jy ms) population of FRBs.

  17. Spin crossover properties of the [Fe(PM-BiA) sub 2 (NCS) sub 2] complex - phases I and II

    CERN Document Server

    Letard, J F; Nguyen, O; Marcen, S; Marchivie, M; Guionneau, P; Chasseau, D; Guetlich, P

    2003-01-01

    In the present review, we reexamine the photomagnetic properties of the [Fe (PM-BiA) sub 2 (NCS) sub 2], cis-bis(thiocyanato)-bis[(N-2'-pyridylmethylene)-4-(aminobiphenyl)] iron(II), compound which exhibits, depending on the synthetic method, an exceptionally abrupt spin transition (phase 1) with a very narrow hysteresis (T sub 1 sub / sub 2 arrow down = 168 K and T sub 1 sub / sub 2 arrow up = 173 K) or a gradual spin conversion (phase II) occurring at 190 K. In both cases, light irradiation in the tail of the sup 1 MLCT-LS absorption band, at 830 nm, results in the population of the high-spin state according to the light-induced excited spin-state trapping (LIESST) effect. The capacity of a compound to retain the light-induced HS information, estimated through the T(LIESST) experiment, is determined for both phases. Interestingly, the shape of the T(LIESST) curve is more gradual for the phase II than for the phase I and the T(LIESST) value is found considerably lower in the case of the phase II. The kinetic...

  18. North Atlantic simulations in Coordinated Ocean-ice Reference Experiments phase II (CORE-II). Part II: Inter-annual to decadal variability

    Science.gov (United States)

    Danabasoglu, Gokhan; Yeager, Steve G.; Kim, Who M.; Behrens, Erik; Bentsen, Mats; Bi, Daohua; Biastoch, Arne; Bleck, Rainer; Böning, Claus; Bozec, Alexandra; Canuto, Vittorio M.; Cassou, Christophe; Chassignet, Eric; Coward, Andrew C.; Danilov, Sergey; Diansky, Nikolay; Drange, Helge; Farneti, Riccardo; Fernandez, Elodie; Fogli, Pier Giuseppe; Forget, Gael; Fujii, Yosuke; Griffies, Stephen M.; Gusev, Anatoly; Heimbach, Patrick; Howard, Armando; Ilicak, Mehmet; Jung, Thomas; Karspeck, Alicia R.; Kelley, Maxwell; Large, William G.; Leboissetier, Anthony; Lu, Jianhua; Madec, Gurvan; Marsland, Simon J.; Masina, Simona; Navarra, Antonio; Nurser, A. J. George; Pirani, Anna; Romanou, Anastasia; Salas y Mélia, David; Samuels, Bonita L.; Scheinert, Markus; Sidorenko, Dmitry; Sun, Shan; Treguier, Anne-Marie; Tsujino, Hiroyuki; Uotila, Petteri; Valcke, Sophie; Voldoire, Aurore; Wang, Qiang; Yashayaev, Igor

    2016-01-01

    Simulated inter-annual to decadal variability and trends in the North Atlantic for the 1958-2007 period from twenty global ocean - sea-ice coupled models are presented. These simulations are performed as contributions to the second phase of the Coordinated Ocean-ice Reference Experiments (CORE-II). The study is Part II of our companion paper (Danabasoglu et al., 2014) which documented the mean states in the North Atlantic from the same models. A major focus of the present study is the representation of Atlantic meridional overturning circulation (AMOC) variability in the participating models. Relationships between AMOC variability and those of some other related variables, such as subpolar mixed layer depths, the North Atlantic Oscillation (NAO), and the Labrador Sea upper-ocean hydrographic properties, are also investigated. In general, AMOC variability shows three distinct stages. During the first stage that lasts until the mid- to late-1970s, AMOC is relatively steady, remaining lower than its long-term (1958-2007) mean. Thereafter, AMOC intensifies with maximum transports achieved in the mid- to late-1990s. This enhancement is then followed by a weakening trend until the end of our integration period. This sequence of low frequency AMOC variability is consistent with previous studies. Regarding strengthening of AMOC between about the mid-1970s and the mid-1990s, our results support a previously identified variability mechanism where AMOC intensification is connected to increased deep water formation in the subpolar North Atlantic, driven by NAO-related surface fluxes. The simulations tend to show general agreement in their temporal representations of, for example, AMOC, sea surface temperature (SST), and subpolar mixed layer depth variabilities. In particular, the observed variability of the North Atlantic SSTs is captured well by all models. These findings indicate that simulated variability and trends are primarily dictated by the atmospheric datasets which

  19. North Atlantic Simulations in Coordinated Ocean-Ice Reference Experiments Phase II (CORE-II) . Part II; Inter-Annual to Decadal Variability

    Science.gov (United States)

    Danabasoglu, Gokhan; Yeager, Steve G.; Kim, Who M.; Behrens, Erik; Bentsen, Mats; Bi, Daohua; Biastoch, Arne; Bleck, Rainer; Boening, Claus; Bozec, Alexandra; Canuto, Vittorio M.; Howard, Armando M.; Kelley, Maxwell

    2015-01-01

    Simulated inter-annual to decadal variability and trends in the North Atlantic for the 1958-2007 period from twenty global ocean - sea-ice coupled models are presented. These simulations are performed as contributions to the second phase of the Coordinated Ocean-ice Reference Experiments (CORE-II). The study is Part II of our companion paper (Danabasoglu et al., 2014) which documented the mean states in the North Atlantic from the same models. A major focus of the present study is the representation of Atlantic meridional overturning circulation (AMOC) variability in the participating models. Relationships between AMOC variability and those of some other related variables, such as subpolar mixed layer depths, the North Atlantic Oscillation (NAO), and the Labrador Sea upper-ocean hydrographic properties, are also investigated. In general, AMOC variability shows three distinct stages. During the first stage that lasts until the mid- to late-1970s, AMOC is relatively steady, remaining lower than its long-term (1958-2007) mean. Thereafter, AMOC intensifies with maximum transports achieved in the mid- to late-1990s. This enhancement is then followed by a weakening trend until the end of our integration period. This sequence of low frequency AMOC variability is consistent with previous studies. Regarding strengthening of AMOC between about the mid-1970s and the mid-1990s, our results support a previously identified variability mechanism where AMOC intensification is connected to increased deep water formation in the subpolar North Atlantic, driven by NAO-related surface fluxes. The simulations tend to show general agreement in their representations of, for example, AMOC, sea surface temperature (SST), and subpolar mixed layer depth variabilities. In particular, the observed variability of the North Atlantic SSTs is captured well by all models. These findings indicate that simulated variability and trends are primarily dictated by the atmospheric datasets which include

  20. A Phase II Study of RO4929097 Gamma-Secretase Inhibitor in Metastatic Melanoma: SWOG 0933

    Science.gov (United States)

    Lee, Sylvia M.; Moon, James; Redman, Bruce G.; Chidiac, Tarek; Flaherty, Lawrence E.; Zha, Yuanyuan; Othus, Megan; Ribas, Antoni; Sondak, Vernon K.

    2014-01-01

    Background Aberrant Notch activation confers a proliferative advantage onto many human tumors, including melanoma. This phase II trial assessed the antitumor activity of RO4929097, a gamma-secretase inhibitor of Notch signaling, on the progression-free and overall survival of patients with advanced melanoma. Methods Chemotherapy-naïve patients with metastatic melanoma of cutaneous or unknown origin were treated with RO4929097 at a dose of 20 mg orally daily, 3 consecutive days per week. A two-step accrual design was used, with an interim analysis on the first 32 patients, and continuation of enrollment if ≥4/32 patients responded. Results Thirty-six patients from 23 institutions were enrolled; 32 patients were evaluable. RO4929097 was well-tolerated, and most toxicities were grade 1 or 2. The most common toxicities were nausea (53%), fatigue (41%), and anemia (22%). There was 1 confirmed partial response lasting 7 months, and 8 patients with stable disease lasting at least through week 12, with one of these continuing for 31 months. The 6-month PFS was 9% (95% CI: 2–22%), and 1-year OS was 50% (95% CI: 32–66%). Peripheral blood T cell assays showed no significant inhibition of IL-2 production, a surrogate pharmacodynamic marker of Notch inhibition, suggesting that the drug levels were insufficient to achieve Notch target inhibition. Conclusions RO4929097 showed minimal clinical activity against metastatic melanoma in this phase II trial, possibly due to inadequate exposure to therapeutic drug levels. While Notch inhibition remains a compelling target in melanoma, our results do not support further investigation of RO4929097 at this dose and schedule. PMID:25250858

  1. Engineering assessment of inactive uranium mill tailings, Naturita site, Naturita, Colorado. Phase II, Title I

    Energy Technology Data Exchange (ETDEWEB)

    1977-11-01

    Ford, Bacon and Davis Utah Inc. has performed an engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at Naturita, Colorado. The Phase II, Title I services include the preparation of topographic maps, the performance of core drillings sufficient to determine areas and volumes of tailings, the performance of radiometric measurements to determine the extent of radium contamination, the evaluation of resulting radiation exposures of individuals and nearby populations, the investigation of site hydrology and meteorology, and the costing of alternative corrective actions. Radon gas release from the 704,000 tons of tailings at the Naturita site constitutes the most significant environmental impact although windblown tailings and external gamma radiation are also factors. Ranchers Exploration and Development Company has been licensed by the State of Colorado to reprocess the tailings at a location 3 mi from the present site where they will be stabilized for long-term storage. The remedial action options include remedial action for structures in Naturita and Nucla (Option I) at an estimated cost of $270,000 and remedial action for structures and open land adjacent to the tailings site (Option II) at an estimated cost of $950,000.

  2. An Overview of Materials Structures for Extreme Environments Efforts for 2015 SBIR Phases I and II

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.

    2017-01-01

    Technological innovation is the overall focus of NASA's Small Business Innovation Research (SBIR) program. The program invests in the development of innovative concepts and technologies to help NASA's mission directorates address critical research and development needs for Agency projects. This report highlights innovative SBIR 2015 Phase I and II projects that specifically address areas in Materials and Structures for Extreme Environments, one of six core competencies at NASA Glenn Research Center. Each article describes an innovation, defines its technical objective, and highlights NASA applications as well as commercial and industrial applications. Ten technologies are featured: metamaterials-inspired aerospace structures, metallic joining to advanced ceramic composites, multifunctional polyolefin matrix composite structures, integrated reacting fluid dynamics and predictive materials degradation models for propulsion system conditions, lightweight inflatable structural airlock (LISA), copolymer materials for fused deposition modeling 3-D printing of nonstandard plastics, Type II strained layer superlattice materials development for space-based focal plane array applications, hydrogenous polymer-regolith composites for radiation-shielding materials, a ceramic matrix composite environmental barrier coating durability model, and advanced composite truss printing for large solar array structures. This report serves as an opportunity for NASA engineers, researchers, program managers, and other personnel to learn about innovations in this technology area as well as possibilities for collaboration with innovative small businesses that could benefit NASA programs and projects.

  3. Engineering assessment of inactive uranium mill tailings, Shiprock site, Shiprock, New Mexico. Phase II, Title I

    Energy Technology Data Exchange (ETDEWEB)

    1977-03-31

    Ford, Bacon and Davis Utah Inc. has performed an engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at Shiprock, New Mexico. The Phase II, Title I services include the preparation of topographic maps, the performance of core drillings and radiometric measurements sufficient to determine areas and volumes of tailings and other radium-contaminated materials, the evaluation of resulting radiation exposures of individuals and nearby populations, the investigation of site hydrology and meteorology and the evaluation and costing of alternative corrective actions. Radon gas release from the 1.7 million tons of tailings at the Shiprock site constitutes the most significant environmental impact, although windblown tailings and external gamma radiation are also factors. The 11 alternative actions presented range from completion of the present ongoing EPA site decontamination plan (Option I), to stabilizing in-place with varying depths of cover material (Options II-IV), to removal to an isolated long-term disposal site (Options V-XI). All options include remedial action costs for off-site locations where tailings have been placed. Costs estimates for the 11 options range from $540,000 to $12,500,000. Reprocessing the tailings for uranium is not economically feasible.

  4. Analysis of Early Severe Accident Initiated by LBLOCA for Qinshan Phase II Nuclear Power Project

    Directory of Open Access Journals (Sweden)

    Shi Xing-Wei

    2013-07-01

    Full Text Available The purpose of this study is to simulate an early Severe Accident (SA scenario more detail through transferring the thermal-hydraulic status of the plant predicted by RELAP5 computer code to SA Program (SAP. Based on the criterion of date extract time, the RELAP5 thermal-hydraulic calculation data is extracted to form a file for SAP input card at 1477K of cladding surface. Relying on the thermal-hydraulic boundary parameters calculated by RELAP5 code, analysis of early SA initiated by the Large Break Loss-of-Coolant Accident (LBLOCA without mitigation measures for Qinshan Phase II Nuclear Power Plant (QSP-II performed by SAP through finding the key events of accident sequence, estimating the amount of hydrogen generation and oxidation behavior of the cladding and evaluating the relocation order of the materials collapsed in the central region of the core. The results of this study are expected to improve the SA analysis methodology more detail through analyzing early SA scenario.

  5. Electron/gamma and alpha backgrounds in CRESST-II Phase 2

    CERN Document Server

    Strauss, R; Bento, A; Bucci, C; Canonica, L; Erb, A; Feilitzsch, F v; Iachellini, N Ferreiro; Gorla, P; Gütlein, A; Hauff, D; Jochum, J; Kiefer, M; Kluck, H; Kraus, H; Lanfranchi, J -C; Loebell, J; Münster, A; Petricca, F; Potzel, W; Pröbst, F; Reindl, F; Roth, S; Rottler, K; Sailer, C; Schäffner, K; Schieck, J; Scholl, S; Schönert, S; Seidel, W; Sivers, M v; Stodolsky, L; Strandhagen, C; Tanzke, A; Uffinger, M; Ulrich, A; Usherov, I; Wawoczny, S; Willers, M; Wüstrich, M; Zöller, A

    2014-01-01

    The experiment CRESST-II aims at the detection of dark matter with scintillating CaWO$_4$ crystals operated as cryogenic detectors. Recent results on spin-independent WIMP-nucleon scattering from the CRESST-II Phase 2 allowed to probe a new region of parameter space for WIMP masses below 3$\\,$GeV/c$^2$. This sensitivity was achieved after background levels were reduced significantly. We present extensive background studies of a CaWO$_4$ crystal, called TUM40, grown at the Technische Universit\\"at M\\"unchen. The average beta/gamma rate of 3.44/[kg$\\,$keV$\\,$day] (1-40$\\,$keV) and the total intrinsic alpha activity from natural decay chains of $3.08\\pm0.04\\,$mBq/kg are the lowest reported for CaWO$_4$ detectors. Contributions of gamma lines resulting from cosmogenic activation, external X-rays and intrinsic beta emitters are investigated in detail.

  6. Robust Type-II Weyl Semimetal Phase in Transition Metal Diphosphides X P2 (X =Mo , W)

    Science.gov (United States)

    Autès, G.; Gresch, D.; Troyer, M.; Soluyanov, A. A.; Yazyev, O. V.

    2016-08-01

    The recently discovered type-II Weyl points appear at the boundary between electron and hole pockets. Type-II Weyl semimetals that host such points are predicted to exhibit a new type of chiral anomaly and possess thermodynamic properties very different from their type-I counterparts. In this Letter, we describe the prediction of a type-II Weyl semimetal phase in the transition metal diphosphides MoP2 and WP2 . These materials are characterized by relatively simple band structures with four pairs of type-II Weyl points. Neighboring Weyl points have the same chirality, which makes the predicted topological phase robust with respect to small perturbations of the crystalline lattice. In addition, this peculiar arrangement of the Weyl points results in long topological Fermi arcs, thus making them readily accessible in angle-resolved photoemission spectroscopy.

  7. Luteal-phase support in assisted reproduction treatment: real-life practices reported worldwide by an updated website-based survey.

    Science.gov (United States)

    Vaisbuch, Edi; de Ziegler, Dominique; Leong, Milton; Weissman, Ariel; Shoham, Zeev

    2014-03-01

    An updated worldwide web-based survey assessed the real-life clinical practices regarding luteal-phase supplementation (LPS) in assisted reproduction. This survey looked for changes since a former survey conducted nearly 3years earlier. The survey questions were: If you support the luteal phase, when do you start the regimen you are using?; Which agent/route is your treatment of choice to support the luteal phase?; If you use vaginal progesterone, which formulation do you use?; and How long you continue progesterone supplementation if the patient conceived? Data were obtained from 408 centres (82 countries) representing 284,600 IVF cycles/year. The findings were: (i) most practitioners (80% of cycles) start LPS on the day of egg collection; (ii) in >90%, a vaginal progesterone product is used (77% as a single agent and 17% in combination with i.m. progesterone), while human chorionic gonadotrophin as a single agent for LPS is not being used at all; and (iii) in 72% of cycles, LPS is administered until 8-10weeks' gestation or beyond. When compared with the initial survey, the results of this survey are encouraging as there is a clear shift towards a more unified and evidence-based approach to LPS in IVF cycles. This updated worldwide web-based survey assessed the actual real-life clinical practices regarding luteal-phase supplementation (LPS) in assisted reproduction. Specifically, this survey looked for changes since an initial survey conducted nearly 3years earlier. The survey included the following questions: If you support the luteal phase, when do you start the regimen you are using?; Which agent/route is your treatment of choice to support the luteal phase?; If you use vaginal progesterone, which formulation do you use?; and How long you continue progesterone supplementation if the patient conceived? Data from 408 centres in 82 countries representing a total of 284,600 IVF cycles/year were included. Most practitioners (80% of cycles) start LPS on the day of

  8. c2d Spitzer IRS Spectra of Disks around T Tauri Stars. III. [Ne II], [Fe I], and H_2 gas-phase lines

    CERN Document Server

    Lahuis, Fred; Blake, Geoffrey A; Evans, Neal J; Kessler-Silacci, Jacqueline E; Pontoppidan, Klaus M

    2007-01-01

    We present a survey of mid-infrared gas-phase lines toward a sample of 76 circumstellar disks around low mass pre-main sequence stars from the Spitzer "Cores to Disks" legacy program. We report the first detections of [Ne II] and [Fe I] toward classical T Tauri stars in ~20% respectively ~9% of our sources. The observed [Ne II] line fluxes and upper limits are consistent with [Ne II] excitation in an X-ray irradiated disk around stars with X-ray luminosities L_X=10^{29}-10^{31} erg s^{-1}. [Fe I] is detected at ~10^-5-10^-4 L_Sun, but no [S I] or [Fe II] is detected down to ~10^{-6} L_Sun. The [Fe I] detections indicate the presence of gas-rich disks with masses of >~0.1 M_J. No H_2 0-0 S(0) and S(1) disk emission is detected, except for S(1) toward one source. These data give upper limits on the warm (T~100-200K) gas mass of a few Jovian masses, consistent with recent T Tauri disk models which include gas heating by stellar radiation. Compact disk emission of hot (T>~500K) gas is observed through the H_2 0-0...

  9. Low energy threshold analysis of the phase I and phase II data sets of the Sudbury neutrino observatory

    Energy Technology Data Exchange (ETDEWEB)

    Seibert, S R [Los Alamos National Laboratory; Hime, A [Los Alamos National Laboratory; Elliott, S R [Los Alamos National Laboratory; Rielage, K [Los Alamos National Laboratory

    2009-01-01

    Results are reported from a joint analysis of Phase I and Phase II data from the Sudbury Neutrino Observatory. The effective electron kinetic energy threshold used is T{sub eff} = 3.5 MeV, the lowest analysis threshold yet achieved with water Cherenkov detector data. In units of 10{sup 6} cm{sup -2} s{sup =1}, the total flux of active-flavor neutrinos from {sup 8}B decay in the Sun measured using the neutral current (NC) reaction of neutrinos on deuterons, with no constraint on the {sup 8}B neutrino energy spectrum, is found to be {Phi}{sub NC} = 5.140{sub -0.158}{sup +0.160}(stat){sub -0.117}{sup +0.132}(syst). These uncertainties are more than a factor of two smaller than previously published results. Also presented are the spectra of recoil electrons from the charged current reaction of neutrinos on deuterons and the elastic scattering of electrons. A fit to the SNO data in which the free parameters directly describe the total {sup 8}B neutrino flux and the energy-dependent Ve survival probability provides a measure of the total {sup 8}B neutrino flux {Phi}{sub 8{sub B}} = 5.046{sub -0.152}{sup +0.159}(stat){sub -0.123}{sup +0.107}(syst). Combining these new results with results of all other solar experiments and the KamLAND reactor experiment yields best-fit values of the mixing parameters of {theta}{sub 12} = 34.06{sub -0.84}{sup +1.16} degrees and {Delta}m{sub 21}{sup 2} = 7.59{sub -0.21}{sup +0.20} x 10{sup -5} eV{sup 2}. The global value of {Phi}{sub 8{sub B}} is extracted to a precision of {sub -2.95}{sup +2.38}%. In a three-flavor analysis the best fit value of sin{sup 2} {theta}{sub 13} is 2.00{sub -1.63}{sup +2.09} x 10{sup -2}. Interpreting this as a limit implies an upper bound of sin{sup 2} {theta}{sub 13} < 0.057 (95% C. L.).

  10. Measurements of the neutron brightness from a phase II solid methane moderator at the LENS neutron source

    Energy Technology Data Exchange (ETDEWEB)

    Shin Yunchang, E-mail: yunchang.shin@yale.ed [Department of Physics, Indiana University Bloomington, IN 47408 (United States); Department of Physics, Yale University, New Haven, CT 06511 (United States); Lavelle, C.M.; Mike Snow, W.; Baxter, David V.; Tong Xin; Yan Haiyang [Department of Physics, Indiana University Bloomington, IN 47408 (United States); Leuschner, Mark [ProCure 420 North Walnut Street Bloomington, IN 47404 (United States)

    2010-08-21

    Measurements of the neutron brightness from a solid methane moderator were performed at the Low Energy Neutron Source (LENS) at the Indiana University Cyclotron Facility (IUCF) to characterize the source and to test our new neutron scattering model of phase II solid methane . A time-of-flight method was used to measure the neutron energy spectrum from the moderator in the energy range of 0.1 meV {approx}1eV. Neutrons were counted with a high efficiency {sup 3}He detector. The solid methane in the moderator occupied phase II and the energy spectra were measured at 20 K and 4 K. We tested our newly developed scattering kernels for phase II solid methane by calculating the neutron brightness expected from the methane moderator at the LENS neutron source using MCNP (Monte Carlo N-particle Transport Code). Within the accuracy of our approximate approach, our model correctly predicts the neutron brightness at both temperatures.

  11. In vivo phase II-enzymes inducers, as potential chemopreventive agents, based on the chalcone and furoxan skeletons.

    Science.gov (United States)

    Cabrera, Mauricio; Mastandrea, Ignacio; Otero, Gabriel; Cerecetto, Hugo; González, Mercedes

    2016-04-15

    Cancer chemoprevention involves prevention/delay/reverse of the carcinogenic process through administration of cancer chemopreventive agents (CCA). Compounds which are able to induce detoxification-enzymes, especially monofunctional phase II enzymes, have become in excellent approaches for new CCA. Herein, we report the synthesis of new furoxanyl chalcone-like hybrid compounds as CCA. In vitro studies showed that phenylfuroxanyl derivatives 6 and 9 displayed the best activities being 9 the greatest monofunctional-inducer. Additionally, compounds were non-mutagenic against TA98 Salmonella typhimurium strain (Ames test) and could be used in the prevention of the progression of pre-malignant lesions for their cytotoxic activity against tumoral cells. In vivo proof of concept showed increment on phase II-enzymes activities in liver, colon and mammary gland having derivative 9 the best induction profiles. We probed Nrf2 nuclear translocation is operative for both compounds allowing to exert protective effects via expression of downstream phase-II enzymes.

  12. Reversed-Phase Liquid Chromatographic Separation and Determination of Ni(II, Cu(II, Pd(II, and Ag(I Using 2-Pyrrolecarboxaldehyde-4-phenylsemicarbazone as a Complexing Reagent

    Directory of Open Access Journals (Sweden)

    Arfana Mallah

    2013-01-01

    Full Text Available This paper reports the utilization of 2-pyrrolecarboxaldehyde-4-phenylsemicarbazone (PPS as a complexing reagent for the simultaneous determination and separation of Ni(II, Cu(II, Pd(II, and Ag(I by reversed-phase high-performance liquid chromatography with UV detector. A good separation was achieved using Microsorb C18 column (150 × 4.6 mm i.d. with a mobile phase consisted of methanol : acetonitrile : water : sodium acetate (1 mM (68 : 6.5 : 25 : 0.5 v/v/v/v at a flow rate of 1 mL/min. The detection was performed at 280 nm. The linear calibration range was 2–10 μg/mL for all metal ions. The detection limits (S/N = 3 were 80 pg/mL for Ni(II, 0.8 ng/mL for Cu(II, 0.16 ng/mL for Pd(II, and 0.8 ng/mL for Ag(I. The applicability and the accuracy of the developed method were estimated by the analysis of Ni(II in hydrogenated oil (ghee samples and Pd(II in palladium charcoal.

  13. Survey of non-linear hydrodynamic models of type-II Cepheids

    Science.gov (United States)

    Smolec, R.

    2016-03-01

    We present a grid of non-linear convective type-II Cepheid models. The dense model grids are computed for 0.6 M⊙ and a range of metallicities ([Fe/H] = -2.0, -1.5, -1.0), and for 0.8 M⊙ ([Fe/H] = -1.5). Two sets of convective parameters are considered. The models cover the full temperature extent of the classical instability strip, but are limited in luminosity; for the most luminous models, violent pulsation leads to the decoupling of the outermost model shell. Hence, our survey reaches only the shortest period RV Tau domain. In the Hertzsprung-Russell diagram, we detect two domains in which period-doubled pulsation is possible. The first extends through the BL Her domain and low-luminosity W Vir domain (pulsation periods ˜2-6.5 d). The second domain extends at higher luminosities (W Vir domain; periods >9.5 d). Some models within these domains display period-4 pulsation. We also detect very narrow domains (˜10 K wide) in which modulation of pulsation is possible. Another interesting phenomenon we detect is double-mode pulsation in the fundamental mode and in the fourth radial overtone. Fourth overtone is a surface mode, trapped in the outer model layers. Single-mode pulsation in the fourth overtone is also possible on the hot side of the classical instability strip. The origin of the above phenomena is discussed. In particular, the role of resonances in driving different pulsation dynamics as well as in shaping the morphology of the radius variation curves is analysed.

  14. A Survey of MgII Absorption at 2 < z < 6 with Magellan / FIRE: I: Sample and Evolution of the MgII Frequency

    CERN Document Server

    Matejek, Michael S

    2012-01-01

    We present initial results from the first systematic survey for MgII quasar absorption lines at z > 2.5. Using infrared spectra of 46 high-redshift quasars, we discovered 111 MgII systems over a path covering 1.9 5, with a maximum of z = 5.33 - the most distant MgII system now known. The comoving MgII line density for weaker systems (Wr < 1.0A) is statistically consistent with no evolution from z = 0.4 to z = 5.5, while that for stronger systems increases three-fold until z \\sim 3 before declining again towards higher redshifts. The equivalent width distribution, which fits an exponential, reflects this evolution by flattening as z approaches 3 before steepening again. The rise and fall of the strong absorbers suggests a connection to the star formation rate density, as though they trace galactic outflows or other byproducts of star formation. The weaker systems' lack of evolution does not fit within this interpretation, but may be reproduced by extrapolating low redshift scaling relations between host ga...

  15. ART CCIM Phase II-A Off-Gas System Evaluation Test Plan

    Energy Technology Data Exchange (ETDEWEB)

    Nick Soelberg; Jay Roach

    2009-01-01

    This test plan defines testing to be performed using the Idaho National Laboratory (INL) engineering-scale cold crucible induction melter (CCIM) test system for Phase II-A of the Advanced Remediation Technologies (ART) CCIM Project. The multi-phase ART-CCIM Project is developing a conceptual design for replacing the joule-heated melter (JHM) used to treat high level waste (HLW) in the Defense Waste Processing Facility (DWPF) at the Savannah River Site (SRS) with a cold crucible induction melter. The INL CCIM test system includes all feed, melter off-gas control, and process control subsystems needed for fully integrated operation and testing. Testing will include operation of the melter system while feeding a non-radioactive slurry mixture prepared to simulate the same type of waste feed presently being processed in the DWPF. Process monitoring and sample collection and analysis will be used to characterize the off-gas composition and properties, and to show the fate of feed constituents, to provide data that shows how the CCIM retrofit conceptual design can operate with the existing DWPF off-gas control system.

  16. Efficacy and safety of liposomal anthracyclines in phase I/II clinical trials.

    Science.gov (United States)

    Alberts, David S; Muggia, Franco M; Carmichael, James; Winer, Eric P; Jahanzeb, Mohammad; Venook, Alan P; Skubitz, Keith M; Rivera, Edgardo; Sparano, Joseph A; DiBella, Nicholas J; Stewart, Simon J; Kavanagh, John J; Gabizon, Alberto A

    2004-12-01

    Preclinical studies have established the pharmacologic advantages of liposomal anthracyclines, including pharmacokinetic profiles after bolus dosing that resemble continuous infusion of conventional anthracyclines, increased drug concentrations in tumor cells compared with the surrounding tissues, and reduced toxicity relative to conventional anthracycline treatment. Based on these studies, many phase I and phase II clinical trials were conducted to assess the safety and potential activity of liposomal anthracyclines in the management of both solid and hematologic tumors. These studies provided valuable insight into the safety of pegylated liposomal doxorubicin (Doxil/Caelyx [PLD]), nonpegylated liposomal doxorubicin (Myocet [NPLD]), and liposomal daunorubicin (DaunoXome [DNX]) over a range of doses, either as single-agent therapy or in combination with other cytotoxic agents. Other liposomal anthracyclines in development may be well tolerated but their activity remains to be elucidated by clinical trials. The available data also suggest that liposomal anthracyclines have activity not only against tumor types with known sensitivity to conventional anthracyclines, but also potentially for tumors that are typically anthracycline-resistant. Despite the availability of clinical data from a wide variety of tumor types and patient populations, further studies of liposomal anthracycline therapy are needed to fully establish their safety, efficacy, and dosing in the treatment of these patients.

  17. Energy Economic Data Base (EEDB) Program: Phase I, Volume II. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    This Volume II of Phase I of the Energy Economic Data Base Program contains appendices. Appendix A-1 provides the site and environmental data, derived from Appendix A of Guide for Economic Evaluation of Nuclear Reactor Plant Designs, USAEC Report NUS-531, modified to reflect current requirements. These data form the bases of the criteria used for designing the facility and for evaluating the routine and accidental release of radioactive liquids and gases to the environment. Appendix A-2 provides the site and environmental data as derived from Appendix A of NUS-531, and modified to reflect coal-plant siting, forming the bases of the criteria used for designing the facility and for evaluating the release of liquids and gases to the environment. A description of the topography of the hypothetical city, Middletown, is given. Appendix B provides an overall summary of the conclusions of NUS' work on all NUS tasks in support of the nuclear fuel-cycle work in Phase I. Appendix C-1 introduces the concepts involved and addresses methods of calculation of fixed charges applicable to investor-owned utilities, as used in the EEDB. Appendix C-2 consists of review and revision of each plant's fuel cycle and operating and maintenance costs in accordance with the EEDB update procedures. In Appendix D, NSSS Capital Costs for a Mature LMFBR Industry, much information is provided on plant description, cost estimate, comparison and discussion, drawings, and equipment list. (MCW)

  18. Comparison between Normal and HeII Two-phase Flows at High Vapor Velocities

    CERN Document Server

    Van Weelderen, R; Rousset, B; Thibault, P; Wolf, P E

    2006-01-01

    We present results on helium co-current two-phase flow experiments at high vapor velocity obtained with the use of the new CEA/SBT 400 W/1.8 K refrigerator [1]. For vapor velocities larger than typically 4 m/s, a mist of droplets develops from the bulk liquid interface accompanied by an increase in heat transfer at the wall. Experiments were conducted in a 10 m long, 40 mm I.D. straight pipe, both in helium II and in helium I to compare these two situations. The respective roles of vapor density, vapor velocity and liquid level on atomization were systematically investigated. Light scattering experiments were performed to measure sizes, velocities and interfacial areas of droplets in a complete cross section. In-house-made heat transfer sensors located in the mist allowed us to deduce an upper value of the extra cooling power of the dispersed phase. The practical interest of atomized flow for cooling large cryogenic facilities is discussed by considering the balance between increase in heat transfer and press...

  19. Phase II: Field Detector Development For Undeclared/Declared Nuclear Testing For Treaty Verfiation Monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Kriz, M. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Hunter, D. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Riley, T. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-10-02

    Radioactive xenon isotopes are a critical part of the Comprehensive Nuclear Test Ban Treaty (CTBT) for the detection or confirmation of nuclear weapons tests as well as on-site treaty verification monitoring. On-site monitoring is not currently conducted because there are no commercially available small/robust field detector devices to measure the radioactive xenon isotopes. Xenon is an ideal signature to detect clandestine nuclear events since they are difficult to contain and can diffuse and migrate through soils due to their inert nature. There are four key radioxenon isotopes used in monitoring: 135Xe (9 hour half-life), 133mXe (2 day half-life), 133Xe (5 day half-life) and 131mXe (12 day half-life) that decay through beta emission and gamma emission. Savannah River National Laboratory (SRNL) is a leader in the field of gas collections and has developed highly selective molecular sieves that allow for the collection of xenon gas directly from air. Phase I assessed the development of a small, robust beta-gamma coincidence counting system, that combines collection and in situ detection methodologies. Phase II of the project began development of the custom electronics enabling 2D beta-gamma coincidence analysis in a field portable system. This will be a significant advancement for field detection/quantification of short-lived xenon isotopes that would not survive transport time for laboratory analysis.

  20. Silicon strip tracking detector development and prototyping for the Phase-II upgrade of the ATLAS experiment

    Science.gov (United States)

    Kuehn, S.

    2016-07-01

    In about ten years from now, the Phase-II upgrade of the LHC will be carried out. Due to increased luminosity, a severe radiation dose and high particle rates will occur for the experiments. In consequence, several detector components will have to be upgraded. In the ATLAS experiment, the current inner detector will be replaced by an all-silicon tracking detector with the goal of at least delivering the present detector performance also in the harsh Phase-II LHC conditions. This report presents the current planning and results from first prototype measurements of the upgrade silicon strip tracking detector.

  1. Electrical Design and Performance of Single- and Double-Sided Silicon Modules for the ATLAS Phase II Upgrade

    CERN Document Server

    Gregor, IM; The ATLAS collaboration

    2012-01-01

    For the planned replacement of the ATLAS tracker during the Phase II Upgrade, the design and construction of a Silicon Strip Detector is currently being planned. In this note, the design plans for the readout structures (hybrids), Silicon-strip modules, readout and powering bus tapes and end-of-substructure cards for the ATLAS Silicon strip system are described. Specific tooling and adhesive requirements are detailed. This document is one of five supporting documents for the silicon strip chapter of the ATLAS Phase II Letter of Intent.

  2. A COMPLETE ATLAS OF H I ABSORPTION TOWARD H II REGIONS IN THE SOUTHERN GALACTIC PLANE SURVEY (SGPS I)

    Energy Technology Data Exchange (ETDEWEB)

    Brown, C.; Dickey, J. M.; Dawson, J. R. [School of Physical Sciences, Private Bag 37, University of Tasmania, Hobart 7001 (Australia); McClure-Griffiths, N. M. [CSIRO Astronomy and Space Science, ATNF, P.O. Box 76, Epping, NSW 1710 (Australia)

    2014-04-01

    We present a complete catalog of H I emission and absorption spectrum pairs, toward H II regions, detectable within the boundaries of the Southern Galactic Plane Survey (SGPS I), a total of 252 regions. The catalog is presented in graphical, numerical, and summary formats. We demonstrate an application of this new data set through an investigation of the locus of the Near 3 kpc Arm.

  3. The Potential Economic Impact of Electricity Restructuring in the State of Oklahoma: Phase II Report

    Energy Technology Data Exchange (ETDEWEB)

    Hadley, SW

    2001-10-30

    Because of the recent experiences of several states undergoing restructuring (e.g., higher prices, greater volatility, lower reliability), concerns have been raised in states currently considering restructuring as to whether their systems are equally vulnerable. Factors such as local generation costs, transmission constraints, market concentration, and market design can all play a role in the success or failure of the market. These factors along with the mix of generation capacity supplying the state will influence the relative prices paid by consumers. The purpose of this project is to provide a model and process to evaluate the potential price and economic impacts of restructuring the Oklahoma electric industry. The Phase I report concentrated on providing an analysis of the Oklahoma system in the near-term, using only present generation resources and customer demands. This Phase II study analyzed the Oklahoma power market in 2010, incorporating the potential of new generation resources and customer responses. Five key findings of this Phase II were made: (1) Projected expansion in generating capacity exceeds by over 3,000 MW the demands within the state plus the amount that could be exported with the current transmission system. (2) Even with reduced new plant construction, most new plants could lose money (although residential consumers would see lower rates) unless they have sufficient market power to raise their prices without losing significant market share (Figure S-1). (3) If new plants can raise prices to stay profitable, existing low-cost coal and hydro plants will have very high profits. Average prices to customers could be 5% to 25% higher than regulated rates (Figure S-1). If the coal and hydro plants are priced at cost-based rates (through long-term contracts or continued regulation) while all other plants use market-based rates then prices are lower. (4) Customer response to real-time prices can lower the peak capacity requirements by around 9

  4. Phase-I and randomized phase-II trial of panobinostat in combination with ICE (ifosfamide, carboplatin, etoposide) in relapsed or refractory classical Hodgkin lymphoma.

    Science.gov (United States)

    Hu, Bei; Younes, Anas; Westin, Jason R; Turturro, Francesco; Claret, Linda; Feng, Lei; Fowler, Nathan; Neelapu, Sattva; Romaguera, Jorge; Hagemeister, Fredrick B; Rodriguez, Maria Alma; Samaniego, Felipe; Fayad, Luis E; Copeland, Amanda R; Nastoupil, Loretta J; Nieto, Yago; Fanale, Michelle A; Oki, Yasuhiro

    2017-08-09

    This phase-I/phase-II study evaluated panobinostat in combination with ifosfamide, carboplatin, etoposide (P-ICE) in relapsed/refractory classical Hodgkin lymphoma. During phase I, panobinostat was given daily on Monday/Wednesday/Friday starting one week prior to Cycle 1 (C1) of ICE and during two weeks of C1-2 of ICE (Schedule A). No DLT was observed at 30 mg. However, frequent (84%) grade-4 thrombocytopenia during second week prompted us to omit the second week of panobinostat 30 mg (Schedule B) for phase II, where this regimen was compared to ICE. In the randomized phase-II study, CR was seen in 9/11 (82%) and 8/12 (67%) for P-ICE and ICE, respectively (p = .64). Grade-4 neutropenia (55% vs. 8%) and thrombocytopenia (100% vs. 33%) were more common in P-ICE. In summary, combination therapy using panobinostat produced high CR rate at the cost of greater bone marrow toxicity. Investigation of panobinostat with less myelosuppressive agents is of interest.

  5. Spin Forming Aluminum Crew Module (CM) Metallic Aft Pressure Vessel Bulkhead (APVBH) - Phase II

    Science.gov (United States)

    Hoffman, Eric K.; Domack, Marcia S.; Torres, Pablo D.; McGill, Preston B.; Tayon, Wesley A.; Bennett, Jay E.; Murphy, Joseph T.

    2015-01-01

    The principal focus of this project was to assist the Multi-Purpose Crew Vehicle (MPCV) Program in developing a spin forming fabrication process for manufacture of the Orion crew module (CM) aft pressure vessel bulkhead. The spin forming process will enable a single piece aluminum (Al) alloy 2219 aft bulkhead resulting in the elimination of the current multiple piece welded construction, simplify CM fabrication, and lead to an enhanced design. Phase I (NASA TM-2014-218163 (1)) of this assessment explored spin forming the single-piece CM forward pressure vessel bulkhead. The Orion MPCV Program and Lockheed Martin (LM) recently made two critical decisions relative to the NESC Phase I work scope: (1) LM selected the spin forming process to manufacture a single-piece aft bulkhead for the Orion CM, and (2) the aft bulkhead will be manufactured from Al 2219. Based on the Program's new emphasis related to the spin forming process, the NESC was asked to conduct a Phase II assessment to assist in the LM manufacture of the aft bulkhead and to conduct a feasibility study into spin forming the Orion CM cone. This activity was approved on June 19, 2013. Dr. Robert Piascik, NASA Technical Fellow for Materials at the Langley Research Center (LaRC), was selected to lead this assessment. The project plan was approved by the NASA Engineering and Safety Center (NESC) Review Board (NRB) on July 18, 2013. The primary stakeholders for this assessment were the NASA and LM MPCV Program offices. Additional benefactors are commercial launch providers developing CM concepts.

  6. Field Surveys, IOC Valleys. Volume III, Part II. Cultural Resources Survey, Pine and Wah Wah Valleys, Utah.

    Science.gov (United States)

    1981-08-01

    including horse, camel, mammoth, Ertm E-TR-48-III-II 20 musk ox, and certain species of bison, goat, and bear, which had previously inhabited the marsh and...34 - - -9,$.. 𔄃 Im I I I Si to * Location lype/Contents Affiliation 42B@644 rid e over cr ek - P/J depression, cleared areas, Fr elon (f4-5-18-92) ground

  7. National databases and rheumatology research II: the National Health and Nutrition Examination Surveys.

    Science.gov (United States)

    Sokka, Tuulikki; Krishnan, Eswar

    2004-11-01

    Three National Health and Nutrition Examination Surveys were conducted in the United States between 1971 and 1994 to provide data on the nutritional and health status of the population and on specific target conditions. This article describes features of the surveys and provides examples of research on musculoskeletal disorders that used the survey data.

  8. Topical report on subsurface fracture mapping from geothermal wellbores. Phase I. Pulsed radar techniques. Phase II. Conventional logging methods. Phase III. Magnetic borehole ranging

    Energy Technology Data Exchange (ETDEWEB)

    Hartenbaum, B.A.; Rawson, G.

    1980-09-01

    To advance the state-of-the-art in Hot Dry Rock technology, an evaluation is made of (i) the use of radar to map far-field fractures, (ii) the use of more than twenty different conventional well logging tools to map borehole-fracture intercepts, and (iii) the use of magnetic dipole ranging to determine the relative positions of the injection well and the production well within the fractured zone. It is found that according to calculations, VHF backscatter radar has the potential for mapping fractures within a distance of 50 +- 20 meters from the wellbore. A new technique for improving fracture identification is presented. Analyses of extant data indicate that when used synergistically the (1) caliper, (2) resistivity dipmeter, (3) televiewer, (4) television, (5) impression packer, and (6) acoustic transmission are useful for mapping borehole-fracture intercepts. Improvements in both data interpretation techniques and high temperature operation are required. The surveying of one borehole from another appears feasible at ranges of up to 200 to 500 meters by using a low frequency magnetic field generated by a moderately strong dipole source (a solenoid) located in one borehole, a sensitive B field detector that traverses part of the second borehole, narrow band filtering, and special data inversion techniques.

  9. Phase 1 Final status survey plan for the West Valley demonstration project.

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, R. L. (Environmental Science Division)

    2011-05-31

    This plan provides the technical basis and associated protocols to support Phase 1 final status survey (FSS) data collection and interpretation as part of the West Valley Demonstration Project Phase 1 Decommissioning Plan process. This plan is consistent with the Multi-Agency Radiation Survey and Site Investigation Manual (MARSSIM). The Phase 1 Decommissioning Plan provides the relevant derived concentration guideline levels (DCGLs) for the Phase 1 radionuclides of interest. This plan includes protocols that will be applied to the deep excavations planned for Waste Management Area (WMA) 1 and WMA 2, for surface soils outside the WMA 1 and WMA 2 excavations that do not have contamination impacts at depths greater than one meter, and for areas that are used for Phase 1 contaminated soil lay-down purposes. All excavated and lay-down areas will be classified as MARSSIM Class 1 areas. Surface soils that have not been excavated, are not expected to exceed DCGLs, and do not have contamination impacts at depths greater than one meter will be divided into either Class 1 or Class 2 areas depending on the expected potential for surface soil contamination in those areas. The plan uses gamma scans combined with biased soil samples to address DCGLemc concerns. The plan uses systematic soil sampling combined with area factors to address DCGLw and DCGLemc concerns. The Sign test will be used to statistically evaluate DCGLw compliance. If the results from the characterization sampling and analysis plan (CSAP) data collection indicate that background may be a significant issue for Sign test implementation, the Wilcoxon rank sum (WRS) test will be used instead to demonstrate DCGLw compliance. A reference area will be selected on the basis of CSAP data results if the WRS test becomes a necessity. The WMA 1 excavation footprint includes approximately 476 foundation pilings that will be trimmed and left in place. Piling-specific systematic and biased sampling will be conducted to

  10. Orthopedic manifestations in patients with muco­polysaccharidosis type II (Hunter syndrome enrolled in the Hunter Outcome Survey

    Directory of Open Access Journals (Sweden)

    Bianca Link

    2010-07-01

    Full Text Available Mucopolysaccharidosis type II (MPS II or Hunter syndrome is a rare, inherited disorder caused by deficiency of the lysosomal enzyme iduronate-2-sulfatase. As a result of this deficiency, glycosaminoglycans accumulate in lysosomes in many tissues, leading to progressive multisystemic disease. The cardiopulmonary and neurological problems associated with MPS II have received considerable attention. Orthopedic manifestations are common but not as well characterized. This study aimed to characterize the prevalence and severity of orthopedic manifestations of MPS II and to determine the relationship of these signs and symptoms with cardiovascular, pulmonary and central nervous system involvement. Orthopedic manifestations of MPS II were studied using cross-sectional data from the Hunter Outcome Survey (HOS. The HOS is a global, physician-led, multicenter observational database that collects information on the natural history of MPS II and the long-term safety and effectiveness of enzyme replacement therapy. As of January 2009, the HOS contained baseline data on joint range of motion in 124 males with MPS II. In total, 79% of patients had skeletal manifestations (median onset, 3.5 years and 25% had abnormal gait (median onset, 5.4 years. Joint range of motion was restricted for all joints assessed (elbow, shoulder, hip, knee and ankle. Extension was the most severely affected movement: the exception to this was the shoulder. Surgery for orthopedic problems was rare. The presence of orthopedic manifestations was associated with the presence of central nervous system and pulmonary involvement, but not so clearly with cardiovascular involvement. Orthopedic interventions should be considered on an individual-patient basis. Although some orthopedic manifestations associated with MPS II may be managed routinely, a good knowledge of other concurrent organ system involvement is essential. A multidisciplinary approach is required.

  11. Seoul National University Bright Quasar Survey in Optical (SNUQSO) I: First Phase Observations and Results

    CERN Document Server

    Lee, Induk; Kim, Minjin; Kang, Eugene; Shim, Hyunjin; Richards, Gordon T; Edge, Alastair C; Lee, Myung Gyoon; Park, Changbom; Park, Myeong-Gu

    2008-01-01

    We present results from the first phase of the Seoul National University Bright Quasar Survey in Optical (SNUQSO) as well as its basic observational setup. Previous and current large-area surveys have been successful in identifying many quasars, but they could have missed bright quasars due to their survey design. In order to help complete the census of bright quasars, we have performed spectroscopic observations of new bright quasar candidates selected from various methods based on optical colors, near-infrared colors, radio, and X-ray data. In 2005/2006, we observed 55 bright quasar candidates using the Bohyunsan Optical Echelle Spectrograph (BOES) on the 1.8 m telescope at the Bohyunsan Optical Astronomy Observatory in Korea. We identify 14 quasars/Seyferts from our observation, including an optically bright quasar with i=14.98 mag at z=0.092 (SDSS J003236.59-091026.2). Non-quasar/Seyfert objects are found to be mostly stars, among which there are five M-type stars and one cataclysmic variable. Our result ...

  12. Cisplatin, 5-fluorouracil, and cetuximab (PFE) with or without cilengitide in recurrent/metastatic squamous cell carcinoma of the head and neck: results of the randomized phase I/II ADVANTAGE trial (phase II part)

    National Research Council Canada - National Science Library

    Vermorken, J B; Peyrade, F; Krauss, J; Mesía, R; Remenar, E; Gauler, T C; Keilholz, U; Delord, J P; Schafhausen, P; Erfán, J; Brümmendorf, T H; Iglesias, L; Bethe, U; Hicking, C; Clement, P M

    2014-01-01

    ... αvβ3 and αvβ5 integrins and is investigated as a treatment strategy. The phase I/II study ADVANTAGE evaluated cilengitide combined with cisplatin, 5-fluorouracil, and cetuximab (PFE) in R/M-SCCHN...

  13. Demonstration Assessment of Light-Emitting Diode (LED) Roadway Lighting, I-35W Bridge, Minneapolis, Minnesota, Phase II Report

    Energy Technology Data Exchange (ETDEWEB)

    Kinzey, B. R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Davis, R. G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-09-30

    On the I-35W Bridge in Minneapolis, Minnesota, the GATEWAY program conducted a two-phase demonstration of LED roadway lighting on the main span, which is one of the country's oldest continuously operated exterior LED lighting installations. The Phase II report documents longer-term performance of the LED lighting system that was installed in 2008, and is the first report on the longer-term performance of LED lighting in the field.

  14. Asteroid phase curve analysis with the H, G 1, G 2 photometric phase function: application to the PTF survey observations

    Science.gov (United States)

    Penttilä, Antti; Cellino, Alberto; Lu, Xiaoping; Shevchenko, Vasilij G.; Muinonen, Karri

    2016-10-01

    Estimation of an asteroid's absolute magnitude H from its photometry is extremely important. The absolute magnitude relates the brightness of the asteroid to its size, if the geometric albedo is known. The shape of the phase curve can serve as a proxy for the taxonomic type of the asteroid in cases with no spectral information available [1,2].In 2012, the IAU adopted the H,G1,G2 function to replace the H,G function for phase curve analysis [3]. This new function improves the backscattering behavior of the curve with high- and low-albedo asteroids. The phase function (PF) can be applied to asteroids with multiple high-quality observations. If the number of observations is small, or their accuracy is low, problems may arise. The most apparent problem is that the parameter G or the parameters G1, G2 might be poorly estimated. The solution has been to fix to value of G or values of G1, G2 and estimate only the H. In our recent work [4], we offer a solution that can improve the current situation with the photometric fits with a small number of low-accuracy observations. We present a constrained nonlinear least-squares method for fitting the H,G1,G2 function that can improve the possible bias with low-accuracy data. Then, we revisit the two-parameter PF with new data and offer a new version, the H,G12* PF. Finally, we assess the problem with fixed G or G1, G2 parameters by introducing one-parameter models that relate to five taxonomic asteroid groups. We tie all the models together with three or two parameters, or a single parameter, with a statistical model selection procedure to select the best version for a particular data set.We have developed practical tools for the abovementioned algorithms. We apply the tools to a dataset of 8,900 asteroids with almost 500,000 photometric observations from the Palomar Transient Factory survey [5]. We report the effect of the revised H estimates on the geometric albedos in cases where WISE-mission size estimates are available.[1] D

  15. Final Report: Phase II Nevada Water Resources Data, Modeling, and Visualization (DMV) Center

    Energy Technology Data Exchange (ETDEWEB)

    Jackman, Thomas [Desert Research Institute; Minor, Timothy [Desert Research Institute; Pohll, Gregory [Desert Research Institute

    2013-07-22

    Water is unquestionably a critical resource throughout the United States. In the semi-arid west -- an area stressed by increase in human population and sprawl of the built environment -- water is the most important limiting resource. Crucially, science must understand factors that affect availability and distribution of water. To sustain growing consumptive demand, science needs to translate understanding into reliable and robust predictions of availability under weather conditions that could be average but might be extreme. These predictions are needed to support current and long-term planning. Similar to the role of weather forecast and climate prediction, water prediction over short and long temporal scales can contribute to resource strategy, governmental policy and municipal infrastructure decisions, which are arguably tied to the natural variability and unnatural change to climate. Change in seasonal and annual temperature, precipitation, snowmelt, and runoff affect the distribution of water over large temporal and spatial scales, which impact the risk of flooding and the groundwater recharge. Anthropogenic influences and impacts increase the complexity and urgency of the challenge. The goal of this project has been to develop a decision support framework of data acquisition, digital modeling, and 3D visualization. This integrated framework consists of tools for compiling, discovering and projecting our understanding of processes that control the availability and distribution of water. The framework is intended to support the analysis of the complex interactions between processes that affect water supply, from controlled availability to either scarcity or deluge. The developed framework enables DRI to promote excellence in water resource management, particularly within the Lake Tahoe basin. In principle, this framework could be replicated for other watersheds throughout the United States. Phase II of this project builds upon the research conducted during

  16. The Building the Bridge survey for z=3 Ly-alpha emitting galaxies II: Completion of the survey

    CERN Document Server

    Grove, L F; Ledoux, C; Limousin, M; Møller, P; Nilsson, K; Thomsen, B

    2009-01-01

    (Abridged). We aim at bridging the gap between absorption selected and emission selected galaxies at z~3 by probing the faint end of the luminosity function of star-forming galaxies at z~3. We have performed narrow-band imaging in three fields with intervening QSO absorbers (a damped Ly$\\alpha$ absorber and two Lyman-limit systems) using the VLT. We target Ly-alpha at redshifts 2.85, 3.15 and 3.20. We find a consistent surface density of about 10 Ly-alpha-emitters per square arcmin per unit redshift in all three fields down to our detection limit of about 3x10^41 ergs s^-1. The luminosity function is consistent with what has been found by other surveys at similar redshifts. About 85% of the sources are fainter than the canonical limit of R=25.5 for most Lyman-break galaxy surveys. In none of the three fields do we detect the emission counterparts of the QSO absorbers. In particular we do not detect the counterpart of the z=2.85 damped Ly-alpha absorber towards Q2138-4427. Narrow-band surveys for Ly-alpha emit...

  17. Final Phase II report : QuickSite(R) investigation, Everest, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M. (Environmental Research)

    2003-11-01

    this reason, the CCC/USDA is conducting an environmental site investigation to determine the source(s) and extent of the carbon tetrachloride contamination at Everest and to assess whether the contamination requires remedial action. The investigation at Everest is being performed by the Environmental Research Division of Argonne National Laboratory. Argonne is a nonprofit, multidisciplinary research center operated by the University of Chicago for the U.S. Department of Energy (DOE). The CCC/USDA has entered into an interagency agreement with DOE, under which Argonne provides technical assistance to the CCC/USDA with environmental site characterization and remediation at its former grain storage facilities. At these facilities, Argonne is applying its QuickSite{reg_sign} environmental site characterization methodology. This methodology has been applied successfully at a number of former CCC/USDA facilities in Kansas and Nebraska and has been adopted by the American Society for Testing and Materials (ASTM 1998) as standard practice for environmental site characterization. Phase I of the QuickSite{reg_sign} investigation examined the key geologic, hydrogeologic, and hydrogeochemical relationships that define potential contaminant migration pathways at Everest (Argonne 2001). Phase II of the QuickSite{reg_sign} investigation at Everest was undertaken with the primary goal of delineating and improving understanding of the distribution of carbon tetrachloride contamination in groundwater at this site and the potential source area(s) that might have contributed to this contamination. To address this goal, four specific technical objectives were developed to guide the Phase II field studies. Sampling of near-surface soils at the former Everest CCC/USDA facility that was originally planned for Phase I had to be postponed until October 2000 because of access restrictions. Viable vegetation was not available for sampling then. This period is termed the first session of Phase II

  18. A Phase I/II Study Combining Erlotinib and Dasatinib for Non-Small Cell Lung Cancer

    Science.gov (United States)

    Gold, Kathryn A.; Lee, J. Jack; Harun, Nusrat; Tang, Ximing; Price, Justina; Kawedia, Jitesh D.; Tran, Hai T.; Erasmus, Jeremy J.; Blumenschein, George R.; William, William N.; Wistuba, Ignacio I.

    2014-01-01

    Background. EGFR and Src are frequently activated in non-small cell lung cancer (NSCLC). In preclinical models, combining EGFR and Src inhibition has additive synergistic effects. We conducted a phase I/II trial of the combination of Src inhibitor dasatinib with EGFR inhibitor erlotinib to determine the maximum tolerated dose (MTD), pharmacokinetic drug interactions, biomarkers, and efficacy in NSCLC. Methods. The phase I 3+3 dose-escalation study enrolled patients with solid tumors to determine the MTD. The phase II trial enrolled patients with advanced NSCLC who had undergone no previous treatments to determine progression-free survival (PFS) and response. Pharmacokinetic and tissue biomarker analyses were performed. Results. MTD was 150 mg of erlotinib and 70 mg of dasatinib daily based on 12 patients treated in the phase I portion. No responses were observed in phase I. The 35 NSCLC patients treated in phase II had an overall disease control rate of 59% at 6 weeks. Five patients (15%) had partial responses; all had activating EGFR mutations. Median PFS was 3.3 months. Epithelial-mesenchymal transition markers did not correlate with outcomes. Conclusion. The combination of erlotinib and dasatinib is safe and feasible in NSCLC. The results of this study do not support use of this combination in molecularly unselected NSCLC. PMID:25170013

  19. Prediction of potential mushroom yield by visible and near-infrared spectroscopy using fresh phase II compost.

    Science.gov (United States)

    Sharma, H S S; Kilpatrick, M; Lyons, G

    2005-08-01

    Potential mushroom (Agaricus bisporus) yield of phase II compost is determined by interactions of key quality parameters including dry matter, nitrogen dry matter, ammonia, pH, conductivity, thermophilic microorganisms, C : N ratio, fiber fractions, ash, and certain minerals. This study was aimed at generating robust visible and near-infrared (Vis-NIR) calibrations for predicting potential yield, using spectra from fresh phase II compost. Four compost comparative trials were carried out during the winter and summer months of 2001-2003, under controlled experimental conditions employing six commercially prepared composts, with eight replicate (8 bag) plots per treatment (48 x 8 = 384). The substrates were prepared by windrow or bunker phase I, followed by phase II production. The fresh samples were scanned for Vis-NIR (400-2498 nm) spectra, averaged, transformed, and regressed against the recorded yield by employing a modified partial least squares algorithm. The best calibration model generated from the database explained 84% of yield variation within the data set with a standard error of calibration of 13.75 kg/tonne of fresh compost. The model was successfully tested for robustness with yield results obtained from a validation trial, carried out under similar experimental conditions in early 2004, and the standard error of prediction was 18.21 kg/tonne, which was slightly higher than the mean experimental error (17.94 kg/tonne) of the trial. The accuracy of the model is acceptable for estimating potential yield by classifying phase II substrate as poor (180-220 kg), medium (220-260 kg), and high (260-300 kg) yielding compost. The yield prediction model is being transferred to a new instrument based at Loughgall for routine evaluation of commercial phase II samples.

  20. Phase selectivity in the synthesis of cobalt(II) 4-cyclohexene-1,2-dicarboxylates under microwave irradiation.

    Science.gov (United States)

    Seo, You-Kyong; Hundal, Geeta; Jeon, Da Hye; Lee, U-Hwang; Hwang, Young Kyu; Chang, Jong-San

    2013-04-01

    Different phases in hybrid complexes of Co(II) with cis-4-cyclohexene-1-2-dicarboxylicacid (C6H8-1,2-CO2H=Cy-H2) have been generated depending on the reaction conditions. By microwave-irradiation of the same reaction mixtures at different temperatures we have obtained two new phases Co(C8H8O4) x H2O and [Co2(OH)2.8(Cy-H)1.2]. These phases have been established by XRD, UV-DRS, IR and thermo-gravimetric studies as well as by comparison with the reported phases. In these phases the Cy is found in a cis conformation. It has been seen that microwave synthesis proves to be a rapid and clean method of obtaining new high temperature phases in high purity which are obtained, in an impure state after a long time of hydrothermal synthesis.

  1. Advanced Start of Combustion Sensor Phases I and II-A: Feasibility Demonstration, Design and Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Chad Smutzer

    2010-01-31

    Homogeneous Compressed Charge Ignition (HCCI) has elevated the need for Start of Combustion (SOC) sensors. HCCI engines have been the exciting focus of engine research recently, primarily because HCCI offers higher thermal efficiency than the conventional Spark Ignition (SI) engines and significantly lower NOx and soot emissions than conventional Compression Ignition (CI) engines, and could be fuel neutral. HCCI has the potential to unify all the internal combustion engine technology to achieve the high-efficiency, low-emission goal. However, these advantages do not come easy. It is well known that the problems encountered with HCCI combustion center on the difficulty of controlling the Start of Combustion. TIAX has an SOC sensor under development which has shown promise. In previous work, including a DOE-sponsored SBIR project, TIAX has developed an accelerometer-based method which was able to determine SOC within a few degrees crank angle for a range of operating conditions. A signal processing protocol allows reconstruction of the combustion pressure event signal imbedded in the background engine vibration recorded by the accelerometer. From this reconstructed pressure trace, an algorithm locates the SOC. This SOC sensor approach is nonintrusive, rugged, and is particularly robust when the pressure event is strong relative to background engine vibration (at medium to high engine load). Phase I of this project refined the previously developed technology with an engine-generic and robust algorithm. The objective of the Phase I research was to answer two fundamental questions: Can the accelerometer-based SOC sensor provide adequate SOC event capture to control an HCCI engine in a feedback loop? And, will the sensor system meet cost, durability, and software efficiency (speed) targets? Based upon the results, the answer to both questions was 'YES'. The objective of Phase II-A was to complete the parameter optimization of the SOC sensor prototype in order

  2. Advanced Start of Combustion Sensor Phases I and II-A: Feasibility Demonstration, Design and Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Chad Smutzer

    2010-01-31

    Homogeneous Compressed Charge Ignition (HCCI) has elevated the need for Start of Combustion (SOC) sensors. HCCI engines have been the exciting focus of engine research recently, primarily because HCCI offers higher thermal efficiency than the conventional Spark Ignition (SI) engines and significantly lower NOx and soot emissions than conventional Compression Ignition (CI) engines, and could be fuel neutral. HCCI has the potential to unify all the internal combustion engine technology to achieve the high-efficiency, low-emission goal. However, these advantages do not come easy. It is well known that the problems encountered with HCCI combustion center on the difficulty of controlling the Start of Combustion. TIAX has an SOC sensor under development which has shown promise. In previous work, including a DOE-sponsored SBIR project, TIAX has developed an accelerometer-based method which was able to determine SOC within a few degrees crank angle for a range of operating conditions. A signal processing protocol allows reconstruction of the combustion pressure event signal imbedded in the background engine vibration recorded by the accelerometer. From this reconstructed pressure trace, an algorithm locates the SOC. This SOC sensor approach is nonintrusive, rugged, and is particularly robust when the pressure event is strong relative to background engine vibration (at medium to high engine load). Phase I of this project refined the previously developed technology with an engine-generic and robust algorithm. The objective of the Phase I research was to answer two fundamental questions: Can the accelerometer-based SOC sensor provide adequate SOC event capture to control an HCCI engine in a feedback loop? And, will the sensor system meet cost, durability, and software efficiency (speed) targets? Based upon the results, the answer to both questions was 'YES'. The objective of Phase II-A was to complete the parameter optimization of the SOC sensor prototype in order

  3. Ultra-secure RF Tags for Safeguards and Security - SBIR Phase II Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Twogood, Richard E [Dirac Solutions Inc., Pleasanton, CA (United States)

    2015-01-27

    This is the Final Report for the DOE Phase II SBIR project “Ultra-secure RF Tags for Safeguards and Security.” The topics covered herein include technical progress made, progress against the planned milestones and deliverables, project outcomes (results, collaborations, intellectual property, etc.), and a discussion on future expectations of deployment and impacts of the results of this work. In brief, all planned work for the project was successfully completed, on or ahead of schedule and on budget. The major accomplishment was the successful development of a very advanced passive ultra-secure RFID tag system with combined security features unmatched by any commercially available ones. These tags have high-level dynamic encrypted authentication, a novel tamper-proofing mechanism, system software including graphical user interfaces and networking, and integration with a fiber-optic seal mechanism. This is all accomplished passively (with no battery) by incorporating sophisticated hardware in the tag which harvests the energy from the RFID readers that are interrogating the tag. Based on initial feedback (and deployments) at DOE’s Lawrence Livermore National Laboratory (LLNL), it is anticipated these tags and their offspring will meet DOE and international community needs for highly secure RFID systems. Beyond the accomplishment of those original objectives for the ultra-secure RF tags, major new spin-off thrusts from the original work were identified and successfully pursued with the cognizance of the DOE sponsor office. In particular, new classes of less sophisticated RFID tags were developed whose lineage derives from the core R&D thrusts of this SBIR. These RF “tag variants” have some, but not necessarily all, of the advanced characteristics described above and can therefore be less expensive and meet far wider markets. With customer pull from the DOE and its national laboratories, new RFID tags and systems (including custom readers and software) for

  4. DOE SBIR Phase II Final Report: Distributed Relevance Ranking in Heterogeneous Document Collections

    Energy Technology Data Exchange (ETDEWEB)

    Abe Lederman

    2007-01-08

    This report contains the comprehensive summary of the work performed on the SBIR Phase II project (“Distributed Relevance Ranking in Heterogeneous Document Collections”) at Deep Web Technologies (http://www.deepwebtech.com). We have successfully completed all of the tasks defined in our SBIR Proposal work plan (See Table 1 - Phase II Tasks Status). The project was completed on schedule and we have successfully deployed an initial production release of the software architecture at DOE-OSTI for the Science.gov Alliance's search portal (http://www.science.gov). We have implemented a set of grid services that supports the extraction, filtering, aggregation, and presentation of search results from numerous heterogeneous document collections. Illustration 3 depicts the services required to perform QuickRank™ filtering of content as defined in our architecture documentation. Functionality that has been implemented is indicated by the services highlighted in green. We have successfully tested our implementation in a multi-node grid deployment both within the Deep Web Technologies offices, and in a heterogeneous geographically distributed grid environment. We have performed a series of load tests in which we successfully simulated 100 concurrent users submitting search requests to the system. This testing was performed on deployments of one, two, and three node grids with services distributed in a number of different configurations. The preliminary results from these tests indicate that our architecture will scale well across multi-node grid deployments, but more work will be needed, beyond the scope of this project, to perform testing and experimentation to determine scalability and resiliency requirements. We are pleased to report that a production quality version (1.4) of the science.gov Alliance's search portal based on our grid architecture was released in June of 2006. This demonstration portal is currently available at http://science.gov/search30

  5. Phase II trial of docetaxel combined with nedaplatin for patients with recurrent and metastatic nasopharyngeal carcinoma

    Directory of Open Access Journals (Sweden)

    Peng PJ

    2015-12-01

    Full Text Available Pei-Jian Peng,1,* Bao-Jun Lv,2,* Con Tang,2,* Hai Liao,3 Zhong Lin,1 Yu-Meng Liu,4 Zhi-Hui Wang,1 Si-Yang Wang,5 Zhi-Bin Cheng5 1Department of Medical Oncology, 2Department of Surgical Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 3Department of Medical Oncology, Cancer Centre, Sun Yat-sen University, Guangzhou, 4Department of Oncology, People’s Hospital of Zhongshan City, Zhongshan, 5Department of Radiation Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, People’s Republic of China *These authors contributed equally to this work Purpose: This Phase II trial was designed to evaluate the efficacy and safety of docetaxel combined with nedaplatin as first-line treatment for patients with recurrent or metastatic nasopharyngeal carcinoma. Methods: In this multicenter Phase II trial, the patients were treated with intravenous docetaxel (75 mg/m2, day 1 and nedaplatin (80 mg/m2, day 1, each cycle repeated every 3 weeks for two cycles at least. Results: From January 2010 to November 2013, a total of 78 patients were recruited in this trial. Among them, 73 patients were assessable for response. The treatment was well tolerated. The main hematological adverse event was neutropenia. A total of 12 patients (15.4% had grade 3 or grade 4 neutropenia. Grade 3 anemia was observed in six patients (7.7% and no grade 3/4 thrombocytopenia was observed. No Grade 3/4 non-hematological toxicity was observed. There were five complete response (6.8%, 43 partial responses (58.9%, and the overall response rate was 65.8% (95% confidence interval [CI], 48.7%–81.2%. With a median follow-up period of 18.6 months, the median time to progression was 7.9 months (95% CI, 4.2–10.8 months, median overall survival was 15.7 months (95% CI, 11.6–18.5 months. Conclusion: Docetaxel combined with nedaplatin offers a satisfactory clinical activity and an acceptable safety profile as first

  6. Few Skewed Disks Found in First Closure-Phase Survey of Herbig Ae/Be stars

    CERN Document Server

    Monnier, J D; Millan-Gabet, R; Traub, W; Schloerb, F P; Pedretti, E; Benisty, M; Carleton, N P; Haguenauer, P; Kern, P; Labeye, P; Lacasse, M G; Malbet, F; Perraut, K; Pearlman, M; Zhao, M

    2006-01-01

    Using the 3-telescope IOTA interferometer on Mt. Hopkins, we report results from the first near-infrared (lambda=1.65 mu) closure-phase survey of Young Stellar Objects (YSOs). These closure phases allow us to unambiguously detect departures from centrosymmetry (i.e., skew) in the emission pattern from YSO disks on the scale of ~4 milliarcseconds, expected from generic ``flared disk'' models. Six of fourteen targets showed small, yet statistically-significant, non-zero closure phases, with largest values from the young binary system MWC 361-A and the (pre-main sequence?) Be star HD 45677. Our observations are quite sensitive to the vertical structure of the inner disk and we confront the predictions of the ``puffed-up inner wall'' models of Dullemond, Dominik, and Natta (DDN). Our data support disks models with curved inner rims because the expected emission appear symmetrically-distributed around the star over a wide range of inclination angles. In contrast, our results are incompatible with the models posses...

  7. First-line treatment with oxaliplatin and capecitabine in patients with advanced or metastatic oesophageal cancer: A phase II study

    NARCIS (Netherlands)

    E. van Meerten (Esther); F.A.L.M. Eskens (Ferry); E.C. van Gameren; L. Doorn; A. van der Gaast (Ate)

    2007-01-01

    textabstractThis phase II study assessed the safety and efficacy of oxaliplatin and capecitabine in patients with advanced oesophageal cancer. Fifty-one eligible patients received oxaliplatin 130 mg m-2intravenously on day 1 and capecitabine 1000 mg m-2orally twice daily on days 1 to 14 in a 21-day

  8. A randomized phase II trial of tacrolimus, mycophenolate mofetil and sirolimus after non-myeloablative unrelated donor transplantation

    DEFF Research Database (Denmark)

    Kornblit, Brian; Maloney, David G; Storer, Barry E

    2014-01-01

    The study is a randomized phase II trial investigating graft-versus-host disease prophylaxis after non-myeloablative (90 mg/m(2) fludarabine and 2 Gy total body irradiation) human leukocyte antigen matched unrelated donor transplantation. Patients were randomized as follows: arm 1 - tacrolimus 18...

  9. A phase II trial with bevacizumab and irinotecan for patients with primary brain tumors and progression after standard therapy

    DEFF Research Database (Denmark)

    Møller, Søren; Grunnet, Kirsten; Hansen, Steinbjørn;

    2012-01-01

    The combination of irinotecan and bevacizumab has shown efficacy in the treatment of recurrent glioblastoma multiforme (GBM). A prospective, phase II study of 85 patients with various recurrent brain tumors was carried out. Primary endpoints were progression free survival (PFS) and response rate....

  10. Phase II study of intensive chemotherapy with autologous bone marrow transplantation in patients in complete remission of disseminated breast cancer

    NARCIS (Netherlands)

    deVries, EGE; Rodenhuis, S; Hupperets, PSGJ; Dolsma, WV; Lebesque, JV; Blijham, GH; Bontenbal, M; Mulder, NH

    1996-01-01

    Background: This trial studied the disease-free survival after high-dose chemotherapy in patients in complete remission of metastatic breast cancer. Patients and methods: Thirty women, mean age 42.2 years (range 33-55) with metastatic breast cancer, received high-dose chemotherapy in a phase II stud

  11. Oral fingolimod (FTY720) in multiple sclerosis: two-year results of a phase II extension study

    DEFF Research Database (Denmark)

    O'Connor, P; Comi, G; Montalban, X;

    2009-01-01

    OBJECTIVE: To report the results of a 24-month extension of a phase II trial assessing the efficacy, safety, and tolerability of the once-daily oral sphingosine-1-phosphate receptor modulator, fingolimod (FTY720), in relapsing multiple sclerosis (MS). METHODS: In the randomized, double-blind, pla...

  12. Pooled analysis of phase II trials evaluating weekly or conventional cisplatin as first-line therapy for advanced urothelial carcinoma

    DEFF Research Database (Denmark)

    Maughan, Benjamin L; Agarwal, Neeraj; Hussain, Syed A;

    2013-01-01

    Weekly gemcitabine with GC every 3-4 weeks is considered conventional first-line chemotherapy for advanced urothelial carcinoma (UC). Weekly split-dose cisplatin with wGC might be less toxic and have similar activity, but has not been compared with GC. We pooled published phase II trials of GC...

  13. Potentiation of a p53-SLP vaccine by cyclophosphamide in ovarian cancer : A single-arm phase II study

    NARCIS (Netherlands)

    Vermeij, Renee; Leffers, Ninke; Hoogeboom, Baukje-Nynke; Hamming, Ineke L. E.; Wolf, Rinze; Reyners, Anna K. L.; Molmans, Barbara H. W.; Hollema, Harry; Bart, Joost; Drijfhout, Jan W.; Oostendorp, Jaap; van der Zee, Ate G. J.; Melief, Cornelis J.; van der Burg, Sjoerd H.; Daemen, Toos; Nijman, Hans W.

    2012-01-01

    The purpose of the current phase II single-arm clinical trial was to evaluate whether pretreatment with low-dose cyclophosphamide improves immunogenicity of a p53-synthetic long peptide (SLP) vaccine in patients with recurrent ovarian cancer. Patients with ovarian cancer with elevated serum levels

  14. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT, C. LEE COOK DIVISION, DOVER CORPORATION, STATIC PAC (TM) SYSTEM, PHASE II REPORT

    Science.gov (United States)

    The Environmental Technology Verification report discusses the technology and performance of the Static Pac System, Phase II, natural gas reciprocating compressor rod packing manufactured by the C. Lee Cook Division, Dover Corporation. The Static Pac System is designed to seal th...

  15. Combined effect of genetic polymorphisms in phase I and II biotransformation enzymes on head and neck cancer risk

    NARCIS (Netherlands)

    Lacko, M.; Voogd, A.C.; Roelofs, H.M.J.; Morsche, R.H.M. te; Ophuis, M.B.; Peters, W.H.M.; Manni, J.J.

    2013-01-01

    BACKGROUND: Combinations of genetic polymorphisms in biotransformation enzymes might modify the individual risk for head and neck cancer. METHODS: Blood from 432 patients with head and neck cancer and 437 controls was investigated for genetic polymorphisms in 9 different phase I and II biotransforma

  16. Interaction-Point Phase-Space Characterization using Single-Beam and Luminous-Region Measurements at PEP-II

    Energy Technology Data Exchange (ETDEWEB)

    Kozanecki, W; /Saclay; Bevan, A.J.; /Queen Mary, U. of London; Viaud, B.F.; /Montreal U.; Cai, Y.; Fisher, A.S.; O' Grady, C.; Lindquist, B.; Roodman, A.; J.M.Thompson, M.Weaver; /SLAC

    2008-09-09

    We present an extensive experimental characterization of the e{sup {+-}} phase space at the interaction point of the SLAC PEP-II B-Factory, that combines a detailed mapping of luminous-region observables using the BABAR detector, with stored-beam measurements by accelerator techniques.

  17. Surveys of complementary and alternative medicine: Part II. Use of alternative and complementary cancer therapies.

    Science.gov (United States)

    Sparber, A; Wootton, J C

    2001-06-01

    The second part of this series on surveys of complementary and alternative medicine (CAM) in the United States provides a "point-of-information" summary of the studies on patients with cancer and their use of CAM therapies. Surveys of patients with cancer were the precursors of the recent wave of studies on CAM prevalence and use. Three tables summarize the findings from a total of 18 surveys categorized by Childhood Cancer, Adult Cancer, and Breast Cancer studies.

  18. A Phase II Study of Cixutumumab (IMC-A12, NSC742460) in Advanced Hepatocellular Carcinoma

    Science.gov (United States)

    Abou-Alfa, Ghassan K.; Capanu, Marinela; O’Reilly, Eileen M.; Ma, Jennifer; Chou, Joanne F.; Gansukh, Bolorsukh; Shia, Jinru; Kalin, Marcia; Katz, Seth; Abad, Leslie; Reidy-Lagunes, Diane L.; Kelsen, David P.; Chen, Helen X.; Saltz, Leonard B.

    2014-01-01

    Background and Aims IGF-IR is implicated in hepatic carcinogenesis. This and preliminary evidence of biological activity of anti-IGF-1R monoclonal antibody cixutumumab in phase I trials prompted this phase II study. Methods Patients with advanced HCC, Child-Pugh A-B8, received cixutumumab 6 mg/kg weekly, in a Simon two-stage design study, with the primary endpoints being 4-month PFS and RECIST-defined response rate. Tissue and circulating markers plus different HCC scoring systems were evaluated for correlation with PFS and OS. Results As a result of pre-specified futility criteria, only stage 1 was accrued: N= 24: median age 67.5 years (range 49–83), KPS 80% (70–90%), 20 males (83%), 9 stage III (37%)/15 stage IV (63%), 18 Child-Pugh A (75%), 11 HBV (46%) /10 HCV (42%)/11 alcoholic cirrhosis (46%)/2 NASH (8%), 11 (46%) diabetic. Median number of doses: 7 (range 1–140). Grade 3/4 toxicities > 10% included: diabetes, elevated liver function tests, hyponatremia, and lymphopenia. Four-month PFS was 30% (95% CI 13–48), and there were no objective responses. Median overall survival was 8 months (95%CI 5.8– 14). IGF-R1 staining did not correlate with outcome. Elevated IGFBP-1 correlated with improved PFS (1.2 [95%CI 1–1.4]; p 0.009) and OS (1.2 [95%CI 1.1–1.4]; p 0.003). Conclusions Cixutumumab monotherapy did not have clinically meaningful activity in this unselected HCC population. Grade 3–4 hyperglycemia occurred in 46% of patients. Elevated IGFBP-1 correlated with improved PFS and OS. PMID:24045151

  19. Predicting Pattern Tooling and Casting Dimensions for Investment Casting, Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Nick Cannell (EMTEC); Adrian S. Sabau (ORNL)

    2005-09-30

    The investment casting process allows the production of complex-shape parts and close dimensional tolerances. One of the most important phases in the investment casting process is the design of the pattern die. Pattern dies are used to create wax patterns by injecting wax into dies. The first part of the project involved preparation of reports on the state of the art at that time for all the areas under consideration (die-wax, wax-shell, and shell-alloy). The primary R&D focus during Phase I was on the wax material since the least was known about it. The main R&D accomplishments during this phase were determination of procedures for obtaining the thermal conductivity and viscoelastic properties of an unfilled wax and validating those procedures. Phase II focused on die-wax and shell-alloy systems. A wax material model was developed based on results obtained during the previous R&D phase, and a die-wax model was successfully incorporated into and used in commercial computer programs. Current computer simulation programs have complementary features. A viscoelastic module was available in ABAQUS but unavailable in ProCAST, while the mold-filling module was available in ProCAST but unavailable in ABAQUS. Thus, the numerical simulation results were only in good qualitative agreement with experimental results, the predicted shrinkage factors being approximately 2.5 times larger than those measured. Significant progress was made, and results showed that the testing and modeling of wax material had great potential for industrial applications. Additional R&D focus was placed on one shell-alloy system. The fused-silica shell mold and A356 aluminum alloy were considered. The experimental part of the program was conducted at ORNL and commercial foundries, where wax patterns were injected, molds were invested, and alloys were poured. It was very important to obtain accurate temperature data from actual castings, and significant effort was made to obtain temperature profiles in

  20. Investigation of HV/HR-CMOS technology for the ATLAS Phase-II Strip Tracker Upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Fadeyev, V., E-mail: fadeyev@ucsc.edu [Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, CA 95064 (United States); Galloway, Z.; Grabas, H.; Grillo, A.A.; Liang, Z.; Martinez-Mckinney, F.; Seiden, A.; Volk, J. [Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, CA 95064 (United States); Affolder, A.; Buckland, M.; Meng, L. [Department of Physics, University of Liverpool, O. Lodge Laboratory, Oxford Street, Liverpool L69 7ZE (United Kingdom); Arndt, K.; Bortoletto, D.; Huffman, T.; John, J.; McMahon, S.; Nickerson, R.; Phillips, P.; Plackett, R.; Shipsey, I. [Department of Physics, Oxford University, Oxford (United Kingdom); and others

    2016-09-21

    ATLAS has formed strip CMOS project to study the use of CMOS MAPS devices as silicon strip sensors for the Phase-II Strip Tracker Upgrade. This choice of sensors promises several advantages over the conventional baseline design, such as better resolution, less material in the tracking volume, and faster construction speed. At the same time, many design features of the sensors are driven by the requirement of minimizing the impact on the rest of the detector. Hence the target devices feature long pixels which are grouped to form a virtual strip with binary-encoded z position. The key performance aspects are radiation hardness compatibility with HL-LHC environment, as well as extraction of the full hit position with full-reticle readout architecture. To date, several test chips have been submitted using two different CMOS technologies. The AMS 350 nm is a high voltage CMOS process (HV-CMOS), that features the sensor bias of up to 120 V. The TowerJazz 180 nm high resistivity CMOS process (HR-CMOS) uses a high resistivity epitaxial layer to provide the depletion region on top of the substrate. We have evaluated passive pixel performance, and charge collection projections. The results strongly support the radiation tolerance of these devices to radiation dose of the HL-LHC in the strip tracker region. We also describe design features for the next chip submission that are motivated by our technology evaluation.

  1. Spectral and thermal studies of solid-phase thermochromism of Co(II) double metal complexes

    Science.gov (United States)

    AL-Sha'alan, Noura H.

    2007-09-01

    Tetrahedral solid state structures of the blue potassium tris(aryloxo)cobaltate(II)-tetrahydrofurane complexes of the formula KCo(OAr) 3·2thf (OAr = o-chloro-, o-bromo-, m-chloro-, p-bromo, 2,6-dichloro-, 2,4-dichloro- or 2,4-dimethylphenoxide) undergo solid-phase thermal tetrahedral to octahedral transformation accompanied by change in their colours from blue to rose (one-step thermochromism). Magnetic moments, electronic and infrared spectral studies supported these results. Thermal treatment of theses complexes leads to the loss of the crystallized thf molecule yielding also blue tetrahedral complexes. However, further heating leads to the loss of the coordinated thf molecule and the formation of rose octahedral trimeric products. TG-DTA results showed that the, two solvated thf molecules were eliminated in two steps. Mass spectral studies and IR intensity measurements confirmed the trimeric behaviour of the rose octahedral geometry of thermal products. Conductance measurements of solutions of these complexes in thf indicated that they behave as non-electrolytes.

  2. Xanthohumol induces phase II enzymes via Nrf2 in human hepatocytes in vitro.

    Science.gov (United States)

    Krajka-Kuźniak, Violetta; Paluszczak, Jarosław; Baer-Dubowska, Wanda

    2013-02-01

    The aim of this study was to investigate whether xanthohumol may exert chemoprotective activity through the modulation of the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway in immortalized normal THLE-2 hepatocytes and a hepatocellular carcinoma HepG2 cell line. Cells were incubated in the presence of xanthohumol and the activation of Nrf2 and expression of genes controlled by this transcription factor were evaluated. Additionally, p53 level was assessed. Xanthohumol increased the expression and led to the activation of Nrf2 in both cell lines. However, in contrast to normal cells the expression of genes controlled by this transcription factor was not affected in HepG2 cells, except for GSTA and GSTP. Xanthohumol, beside the induction of GSTs and HO-1, significantly elevated NQO1 expression in concert with p53 level in normal hepatocytes. The activation of Nrf2 pathway and subsequently phase II enzymes in concert with p53 induction in normal hepatocytes may account for the molecular mechanism of the chemopreventive activity of xanthohumol. On the other hand its cytotoxicity towards HCC cells shown in this study indicates that it may also be considered as potentially chemotherapeutic.

  3. Silicon sensor prototypes for the Phase II upgrade of the CMS tracker

    Energy Technology Data Exchange (ETDEWEB)

    Bergauer, Thomas, E-mail: thomas.bergauer@oeaw.ac.at

    2016-09-21

    The High-Luminosity LHC (HL-LHC) has been identified as the highest priority program in High Energy Physics in the mid-term future. It will provide the experiments an additional integrated luminosity of about 2500 fb{sup −1} over 10 years of operation, starting in 2025. In order to meet the experimental challenges of unprecedented p–p luminosity, especially in terms of radiation levels and occupancy, the CMS collaboration will need to replace its entire strip tracker by a new one. In this paper the baseline layout option for this new Phase-II tracker is shown, together with two variants using a tilted barrel geometry or larger modules from 8-inch silicon wafers. Moreover, the two module concepts are discussed, which consist either of two strip sensors (2S) or of one strip and one pixel sensor (PS). These two designs allow p{sub T} discrimination at module level enabling the tracker to contribute to the L1 trigger decision. The paper presents testing results of the macro-pixel-light sensor for the PS module and shows the first electrical characterization of unirradiated, full-scale strip sensor prototypes for the 2S module concept, both on 6- and 8-inch wafers.

  4. Phase II Study of Temozolomide and Thalidomide in Patients with Unresectable or Metastatic Leiomyosarcoma

    Directory of Open Access Journals (Sweden)

    Michelle S. Boyar

    2008-01-01

    Full Text Available We assessed the efficacy of combined temozolomide and thalidomide in patients with unresectable or metastatic leiomyosarcoma in a phase II single-institution trial. Twenty-four patients were enrolled. Temozolomide (150 mg/m2/day for 7 days every other week was administered with concomitant thalidomide (200 mg/day, and continued until unacceptable toxicity or disease progression. There were no complete responses and two (10% partial responses. Five patients (24% had stable disease for at least six months. Fourteen patients (67% progressed after a median of two-month treatment. The median overall survival (twenty-two assessable patients was 9.5 months [95% CI 7–28 months]. There were no treatment-related deaths or CTC grade 4 toxicities. Thirteen patients were dose-reduced or discontinued thalidomide due to toxicity. In conclusion, this combination of temozolomide and thalidomide provided disease stabilization in a subset of patients with advanced leiomyosarcoma. We hypothesize that temozolomide is the active agent in this regimen, and should be further studied.

  5. A phase II trial of a biweekly combination of paclitaxel and gemcitabine in metastatic breast cancer

    Directory of Open Access Journals (Sweden)

    Spinelli Gian

    2006-05-01

    Full Text Available Abstract Background Many emerging new drugs have recently been trialled for treatment of early and advanced breast cancer. Among these new agents paclitaxel and gemcitabine play a crucial role, mostly in patients with relapsed and metastatic disease after failure of chemotherapy with antracyclines. Methods A phase II study was started in order to evaluate the activity and toxicity of a combination of paclitaxel and gemcitabine in a biweekly schedule on metastatic breast cancer patients previously treated with antracyclines. Results Twenty-five patients received paclitaxel (150 mg/mq by 3-hours infusion, followed by gemcitabine (2000 mg/mq given as a 60 min i.v. infusion (day 1–14 for a maximum of eight cycles. In all patients treatment was evaluated for toxicity and efficacy; four patients (16% achieved a complete response, 12 (48% a partial response giving an overall objective response rate of 64%. Stable disease was documented in 5 patients (20% and progressive disease occurred in 4 patients (16%. Conclusion The schedule of treatment was safe and tolerable from a haematological and non-haematological point of view. These data confirm that the combination of gemcitabine and paclitaxel on a biweekly basis is an effective and well-tolerated regimen in breast cancer patients with prior therapeutic exposure to antracyclines.

  6. A phase II trial of a biweekly combination of paclitaxel and gemcitabine in metastatic breast cancer

    Science.gov (United States)

    Tomao, Silverio; Romiti, Adriana; Tomao, Federica; Di Seri, Marisa; Caprio, Giuliana; Spinelli, Gian Paolo; Terzoli, Edmondo; Frati, Luigi

    2006-01-01

    Background Many emerging new drugs have recently been trialled for treatment of early and advanced breast cancer. Among these new agents paclitaxel and gemcitabine play a crucial role, mostly in patients with relapsed and metastatic disease after failure of chemotherapy with antracyclines. Methods A phase II study was started in order to evaluate the activity and toxicity of a combination of paclitaxel and gemcitabine in a biweekly schedule on metastatic breast cancer patients previously treated with antracyclines. Results Twenty-five patients received paclitaxel (150 mg/mq) by 3-hours infusion, followed by gemcitabine (2000 mg/mq) given as a 60 min i.v. infusion (day 1–14) for a maximum of eight cycles. In all patients treatment was evaluated for toxicity and efficacy; four patients (16%) achieved a complete response, 12 (48%) a partial response giving an overall objective response rate of 64%. Stable disease was documented in 5 patients (20%) and progressive disease occurred in 4 patients (16%). Conclusion The schedule of treatment was safe and tolerable from a haematological and non-haematological point of view. These data confirm that the combination of gemcitabine and paclitaxel on a biweekly basis is an effective and well-tolerated regimen in breast cancer patients with prior therapeutic exposure to antracyclines. PMID:16723016

  7. THE WIDE-AREA ENERGY STORAGE AND MANAGEMENT SYSTEM PHASE II Final Report - Flywheel Field Tests

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Ning; Makarov, Yuri V.; Weimar, Mark R.; Rudolph, Frank; Murthy, Shashikala; Arseneaux, Jim; Loutan, Clyde; Chowdhury, S.

    2010-08-31

    This research was conducted by Pacific Northwest National Laboratory (PNNL) operated for the U.S. department of Energy (DOE) by Battelle Memorial Institute for Bonneville Power Administration (BPA), California Institute for Energy and Environment (CIEE) and California Energy Commission (CEC). A wide-area energy management system (WAEMS) is a centralized control system that operates energy storage devices (ESDs) located in different places to provide energy and ancillary services that can be shared among balancing authorities (BAs). The goal of this research is to conduct flywheel field tests, investigate the technical characteristics and economics of combined hydro-flywheel regulation services that can be shared between Bonneville Power Administration (BPA) and California Independent System Operator (CAISO) controlled areas. This report is the second interim technical report for Phase II of the WAEMS project. This report presents: 1) the methodology of sharing regulation service between balancing authorities, 2) the algorithm to allocate the regulation signal between the flywheel and hydro power plant to minimize the wear-and-tear of the hydro power plants, 3) field results of the hydro-flywheel regulation service (conducted by the Beacon Power), and 4) the performance metrics and economic analysis of the combined hydro-flywheel regulation service.

  8. Investigation of HV/HR-CMOS technology for the ATLAS Phase-II Strip Tracker Upgrade

    Science.gov (United States)

    Fadeyev, V.; Galloway, Z.; Grabas, H.; Grillo, A. A.; Liang, Z.; Martinez-Mckinney, F.; Seiden, A.; Volk, J.; Affolder, A.; Buckland, M.; Meng, L.; Arndt, K.; Bortoletto, D.; Huffman, T.; John, J.; McMahon, S.; Nickerson, R.; Phillips, P.; Plackett, R.; Shipsey, I.; Vigani, L.; Bates, R.; Blue, A.; Buttar, C.; Kanisauskas, K.; Maneuski, D.; Benoit, M.; Di Bello, F.; Caragiulo, P.; Dragone, A.; Grenier, P.; Kenney, C.; Rubbo, F.; Segal, J.; Su, D.; Tamma, C.; Das, D.; Dopke, J.; Turchetta, R.; Wilson, F.; Worm, S.; Ehrler, F.; Peric, I.; Gregor, I. M.; Stanitzki, M.; Hoeferkamp, M.; Seidel, S.; Hommels, L. B. A.; Kramberger, G.; Mandić, I.; Mikuž, M.; Muenstermann, D.; Wang, R.; Zhang, J.; Warren, M.; Song, W.; Xiu, Q.; Zhu, H.

    2016-09-01

    ATLAS has formed strip CMOS project to study the use of CMOS MAPS devices as silicon strip sensors for the Phase-II Strip Tracker Upgrade. This choice of sensors promises several advantages over the conventional baseline design, such as better resolution, less material in the tracking volume, and faster construction speed. At the same time, many design features of the sensors are driven by the requirement of minimizing the impact on the rest of the detector. Hence the target devices feature long pixels which are grouped to form a virtual strip with binary-encoded z position. The key performance aspects are radiation hardness compatibility with HL-LHC environment, as well as extraction of the full hit position with full-reticle readout architecture. To date, several test chips have been submitted using two different CMOS technologies. The AMS 350 nm is a high voltage CMOS process (HV-CMOS), that features the sensor bias of up to 120 V. The TowerJazz 180 nm high resistivity CMOS process (HR-CMOS) uses a high resistivity epitaxial layer to provide the depletion region on top of the substrate. We have evaluated passive pixel performance, and charge collection projections. The results strongly support the radiation tolerance of these devices to radiation dose of the HL-LHC in the strip tracker region. We also describe design features for the next chip submission that are motivated by our technology evaluation.

  9. Intensified Adjuvant Treatment of Prostate Carcinoma: Feasibility Analysis of a Phase I/II Trial

    Science.gov (United States)

    Mantini, Giovanna; Fersino, Sergio; Frascino, Vincenzo; Massaccesi, Mariangela; Fionda, Bruno; Luzi, Stefano; Balducci, Mario; De Belvis, Antonio; Morganti, Alessio Giuseppe; Valentini, Vincenzo

    2014-01-01

    Purpose. To perform a preliminary feasibility acute and late toxicity evaluation of an intensified and modulated adjuvant treatment in prostate cancer (PCa) patients after radical prostatectomy. Material and Methods. A phase I/II has been designed. Eligible patients were 79 years old or younger, with an ECOG of 0–2, previously untreated, histologically proven prostate adenocarcinoma with no distant metastases, pT2–4 N0-1, and with at least one of the following risk factors: capsular perforation, positive surgical margins, and seminal vesicle invasion. All patients received a minimum dose on tumor bed of 64.8 Gy, or higher dose (70.2 Gy; 85.4%), according to the pathological stage, pelvic lymph nodes irradiation (57.7%), and/or hormonal therapy (69.1%). Results. 123 patients were enrolled and completed the planned treatment, with good tolerance. Median follow-up was 50.6 months. Grade 3 acute toxicity was only 2.4% and 3.3% for genitourinary (GU) and gastrointestinal (GI) tract, respectively. No patient had late grade 3 GI toxicity, and the GU grade 3 toxicity incidence was 5.8% at 5 years. 5-year BDSF was 90.2%. Conclusions. A modulated and intensified adjuvant treatment in PCa was feasible in this trial. A further period of observation can provide a complete assessment of late toxicity and confirm the BDSF positive results. PMID:25093169

  10. An Overview of Power, Energy Storage, and Conversion Efforts for 2014 SBIR Phases I and II

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.

    2016-01-01

    Technological innovation is the overall focus of NASA's Small Business Innovation Research (SBIR) program. The program invests in the development of innovative concepts and technologies to help NASA's mission directorates address critical research and development needs for agency projects. NASA's Small Business Innovation Research (SBIR) program focuses on technological innovation by investing in development of innovative concepts and technologies to help NASA mission directorates address critical research needs for Agency programs. This report highlights 15 of the innovative SBIR 2014 Phase I and II projects that focus on one of NASA Glenn Research Center's six core competencies-Power, Energy Storage and Conversion. The technologies cover a wide spectrum of applications such as high-radiation-tolerant ceramic voltage isolators, development of hermetic sealing glasses for solid oxide fuel cells, rechargeable lithium metal cells, high-efficiency direct methane solid oxide fuel cell systems, Li metal protection for high-energy space batteries, isolated bidirectional direct current converters for distributed battery energy applications, and high-efficiency rad-hard ultrathin Si photovoltaic cell technology for space. Each article describes an innovation and technical objective and highlights NASA commercial and industrial applications. This report provides an opportunity for NASA engineers, researchers, and program managers to learn how NASA SBIR technologies could help their programs and projects, and lead to collaborations and partnerships between the small SBIR companies and NASA that would benefit both.

  11. The PreProcessors for the ATLAS Tile Calorimeter Phase II Upgrade

    CERN Document Server

    Carrio Argos, Fernando; The ATLAS collaboration

    2015-01-01

    The Large Hadron Collider (LHC) has envisaged a series of upgrades towards a High Luminosity LHC (HL-LHC) delivering five times the LHC nominal instantaneous luminosity. The ATLAS Phase II upgrade will accommodate the detector and data acquisition system for the HL-LHC. In particular, the Tile Hadronic Calorimeter (TileCal) will replace completely on- and off-detector electronics using a new read-out architecture. The digitized detector data will be transferred for every beam crossing to the super Read Out Drivers (sRODs) located in off-detector counting rooms with a total data bandwidth of roughly 80 Tbps. The sROD implements increased pipelines memories and must provide pre-processed digital trigger information to Level 0/1 systems. The sROD module represents the link between the on-detector electronics and the overall ATLAS data acquisition system. It also implements the interface between the Detector Control System (DCS) and the on-detector electronics which is used to control and monitor the high voltage...

  12. The PreProcessors for the ATLAS Tile Calorimeter Phase II Upgrade

    CERN Document Server

    Carrio Argos, Fernando; The ATLAS collaboration

    2015-01-01

    The Large Hadron Collider (LHC) has envisaged a series of upgrades towards a High Luminosity LHC (HL-LHC) delivering five times the LHC nominal instantaneous luminosity. The ATLAS Phase II upgrade will accommodate the detector and data acquisition system for the HL-LHC. In particular, the Tile Hadronic Calorimeter (TileCal) will replace completely front-end and back-end electronics using a new readout architecture. The digitized detector data will be transferred for every beam crossing to the PreProcessors (TilePPr) located in off-detector counting rooms with a total data bandwidth of roughly 80 Tbps. The TilePPr implements increased pipelines memories and must provide pre-processed digital trigger information to Level 0 trigger systems. The TilePPr system represents the link between the front-end electronics and the overall ATLAS data acquisition system. It also implements the interface between the Detector Control System (DCS) and the front-end electronics which is used to control and monitor the high volta...

  13. Tests with beam setup of the TileCal phase-II upgrade electronics

    Science.gov (United States)

    Reward Hlaluku, Dingane

    2017-09-01

    The LHC has planned a series of upgrades culminating in the High Luminosity LHC which will have an average luminosity 5-7 times larger than the nominal Run-2 value. The ATLAS Tile calorimeter plans to introduce a new readout architecture by completely replacing the back-end and front-end electronics for the High Luminosity LHC. The photomultiplier signals will be fully digitized and transferred for every bunch crossing to the off-detector Tile PreProcessor. The Tile PreProcessor will further provide preprocessed digital data to the first level of trigger with improved spatial granularity and energy resolution in contrast to the current analog trigger signals. A single super-drawer module commissioned with the phase-II upgrade electronics is to be inserted into the real detector to evaluate and qualify the new readout and trigger concepts in the overall ATLAS data acquisition system. This new super-drawer, so-called hybrid Demonstrator, must provide analog trigger signals for backward compatibility with the current system. This Demonstrator drawer has been inserted into a Tile calorimeter module prototype to evaluate the performance in the lab. In parallel, one more module has been instrumented with two other front-end electronics options based on custom ASICs (QIE and FATALIC) which are under evaluation. These two modules together with three other modules composed of the current system electronics were exposed to different particles and energies in three test-beam campaigns during 2015 and 2016.

  14. Phase-II conjugation ability for PAH metabolism in amphibians: characteristics and inter-species differences.

    Science.gov (United States)

    Ueda, Haruki; Ikenaka, Yoshinori; Nakayama, Shouta M M; Tanaka-Ueno, Tomoko; Ishizuka, Mayumi

    2011-10-01

    The present study examines amphibian metabolic activity - particularly conjugation - by analysis of pyrene (a four ring, polycyclic aromatic hydrocarbon) metabolites using high-performance liquid chromatography (HPLC) with fluorescence detector (FD), a mass spectrometry detector (MS) system and kinetic analysis of conjugation enzymes. Six amphibian species were exposed to pyrene (dissolved in water): African claw frog (Xenopus laevis); Tago's brown frog (Rana tagoi); Montane brown frog (Rana ornativentris); Wrinkled frog (Rana rugosa); Japanese newt (Cynops pyrrhogaster); and Clouded salamander (Hynobius nebulosus); plus one fish species, medaka (Oryzias latipes); and a fresh water snail (Clithon retropictus), and the resultant metabolites were collected. Identification of pyrene metabolites by HPLC and ion-trap MS system indicated that medaka mainly excreted pyrene-1-glucuronide (PYOG), while pyrene-1-sulfate (PYOS) was the main metabolite in all amphibian species. Pyrene metabolites in amphibians were different from those in invertebrate fresh water snails. Inter-species differences were also observed in pyrene metabolism among amphibians. Metabolite analysis showed that frogs relied more strongly on sulfate conjugation than did Japanese newts and clouded salamanders. Furthermore, urodelan amphibians, newts and salamanders, excreted glucose conjugates of pyrene that were not detected in the anuran amphibians. Kinetic analysis of conjugation by hepatic microsomes and cytosols indicated that differences in excreted metabolites reflected differences in enzymatic activities. Furthermore, pyrenediol (PYDOH) glucoside sulfate was detected in the Japanese newt sample. This novel metabolite has not been reported previously to this report, in which we have identified unique characteristics of amphibians in phase II pyrene metabolism.

  15. Optical link card design for the phase II upgrade of TileCal experiment

    CERN Document Server

    Carrio, F; Ferrer, A; Gonzalez, V; Higon, E; Marin, C; Moreno, P; Sanchis, E; Solans, C; Valero, A; Valls, J

    2011-01-01

    This paper presents the design of an optical link card developed in the frame of the R&D activities for the phase 2 upgrade of the TileCal experiment. This board, that is part of the evaluation of different technologies for the final choice in the next years, is designed as a mezzanine that can work independently or be plugged in the optical multiplexer board of the TileCal backend electronics. It includes two SNAP 12 optical connectors able to transmit and receive up to 75 Gb/s and one SFP optical connector for lower speeds and compatibility with existing hardware as the read out driver. All processing is done in a Stratix II GX field-programmable gate array (FPGA). Details are given on the hardware design, including signal and power integrity ana lysis, needed when working with these high data rates and on firmware development to obtain the best performance of the FPGA signal transceivers and for the use of the GBT protocol.

  16. Intensified Adjuvant Treatment of Prostate Carcinoma: Feasibility Analysis of a Phase I/II Trial

    Directory of Open Access Journals (Sweden)

    Giovanna Mantini

    2014-01-01

    Full Text Available Purpose. To perform a preliminary feasibility acute and late toxicity evaluation of an intensified and modulated adjuvant treatment in prostate cancer (PCa patients after radical prostatectomy. Material and Methods. A phase I/II has been designed. Eligible patients were 79 years old or younger, with an ECOG of 0–2, previously untreated, histologically proven prostate adenocarcinoma with no distant metastases, pT2–4 N0-1, and with at least one of the following risk factors: capsular perforation, positive surgical margins, and seminal vesicle invasion. All patients received a minimum dose on tumor bed of 64.8 Gy, or higher dose (70.2 Gy; 85.4%, according to the pathological stage, pelvic lymph nodes irradiation (57.7%, and/or hormonal therapy (69.1%. Results. 123 patients were enrolled and completed the planned treatment, with good tolerance. Median follow-up was 50.6 months. Grade 3 acute toxicity was only 2.4% and 3.3% for genitourinary (GU and gastrointestinal (GI tract, respectively. No patient had late grade 3 GI toxicity, and the GU grade 3 toxicity incidence was 5.8% at 5 years. 5-year BDSF was 90.2%. Conclusions. A modulated and intensified adjuvant treatment in PCa was feasible in this trial. A further period of observation can provide a complete assessment of late toxicity and confirm the BDSF positive results.

  17. Doxycycline plus tauroursodeoxycholic acid for transthyretin amyloidosis: a phase II study.

    Science.gov (United States)

    Obici, Laura; Cortese, Andrea; Lozza, Alessandro; Lucchetti, J; Gobbi, Marco; Palladini, Giovanni; Perlini, Stefano; Saraiva, Maria J; Merlini, Giampaolo

    2012-06-01

    We designed a phase II, open-label study to evaluate the efficacy, tolerability, safety, and pharmacokinetics of orally doxycycline (100 mg BID) and tauroursodeoxycholic acid (TUDCA) (250 mg three times/day) administered continuously for 12 months. Primary endpoint is response rate defined as nonprogression of the neuropathy and of the cardiomyopathy. Since July 2010, we enrolled 20 patients. Seventeen patients have hereditary ATTR, two patients have senile systemic amyloidosis, and one is a domino recipient. Seven patients completed 12-month treatment, 10 completed 6-month treatment, two discontinued because of poor tolerability, and one is lost at follow-up. No serious adverse events were registered. No clinical progression of cardiac involvement was observed. The neuropathy (Neuropathy Impairment Score in the Lower Limbs [NIS-LL] and Kumamoto score) remained substantially stable over 1 year. These preliminary data indicate that the combination of Doxy-TUDCA stabilizes the disease for at least 1 year in the majority of patients with an acceptable toxicity profile.

  18. Culture and Use of Mesenchymal Stromal Cells in Phase I and II Clinical Trials

    Directory of Open Access Journals (Sweden)

    Bourin Philippe

    2010-01-01

    Full Text Available Present in numerous tissues, mesenchymal stem cells/multipotent stromal cells (MSCs can differentiate into different cell types from a mesoderm origin. Their potential has been extended to pluripotency, by their possibility of differentiating into tissues and cells of nonmesodermic origin. Through the release of cytokines, growth factors and biologically active molecules, MSCs exert important paracrine effects during tissue repair and inflammation. Moreover, MSCs have immunosuppressive properties related to non-HLA restricted immunosuppressive capacities. All these features lead to an increasing range of possible applications of MSCs, from treating immunological diseases to tissue and organ repair, that should be tested in phase I and II clinical trials. The most widely used MSCs are cultured from bone marrow or adipose tissue. For clinical trial implementation, BM MSCs and ADSCs should be produced according to Good Manufacturing Practices. Safety remains the major concern and must be ensured during culture and validated with relevant controls. We describe some applications of MSCs in clinical trials.

  19. Culture and Use of Mesenchymal Stromal Cells in Phase I and II Clinical Trials

    Science.gov (United States)

    Philippe, Bourin; Luc, Sensebé; Valérie, Planat-Bénard; Jérôme, Roncalli; Alessandra, Bura-Rivière; Louis, Casteilla

    2010-01-01

    Present in numerous tissues, mesenchymal stem cells/multipotent stromal cells (MSCs) can differentiate into different cell types from a mesoderm origin. Their potential has been extended to pluripotency, by their possibility of differentiating into tissues and cells of nonmesodermic origin. Through the release of cytokines, growth factors and biologically active molecules, MSCs exert important paracrine effects during tissue repair and inflammation. Moreover, MSCs have immunosuppressive properties related to non-HLA restricted immunosuppressive capacities. All these features lead to an increasing range of possible applications of MSCs, from treating immunological diseases to tissue and organ repair, that should be tested in phase I and II clinical trials. The most widely used MSCs are cultured from bone marrow or adipose tissue. For clinical trial implementation, BM MSCs and ADSCs should be produced according to Good Manufacturing Practices. Safety remains the major concern and must be ensured during culture and validated with relevant controls. We describe some applications of MSCs in clinical trials. PMID:21052537

  20. Results of the phase II study of photodynamic therapy in Japan

    Science.gov (United States)

    Konaka, Chimori; Kato, Harubumi; Okunaka, Tetsuya; Hayata, Yoshihiro

    1994-07-01

    Photodynamic therapy (PDT) utilizing Photofrin has proven to be an effective modality used in the treatment of solid tumors. In particular, it can be applied via endoscopy to lesions developing in luminal organs. A phase II study was conducted for submission to the Japanese Ministry of Health and Welfare. In this protocol an excimer dye laser was used to deliver 630 nm light via a quartz fiber passed through an endoscopic working channel two days subsequent to i.v. injection of photosensitizer. In this study, 98 patients with superficial cancer of various organs were treated. Of these, 88 patients could be evaluated, including 33 with roentgenographically occult lung cancer, 10 with esophageal cancer, 24 with gastric cancer, 18 with cervical cancer and three with bladder cancer. Complete remission as evaluated endoscopically, pathologically, and cytologically was obtained in 83 out of 98 (84.7). There was no serious complication except mild skin photosensitivity, which was seen in four patients. It was concluded that PDT can be efficacious in the treatment of superficial cancers and that complete remission can be achieved when suitable photoradiation conditions are met.

  1. Thermal imaging QC for silicon strip staves of the ATLAS phase II upgrade

    Science.gov (United States)

    Vergel Infante, Carlos

    2016-03-01

    A new silicon strip detector is part of the phase II upgrade of the ATLAS inner tracker. Light-material carbon fiber honeycomb sandwich staves serve as mechanical support for the strip sensors and readout modules and to move the dissipated heat out of the detector. A cooling pipe inside the stave is embedded in heat-conducting foam that thermally connects the pipe with the readout modules. The staves are required to pass a set of quality control (QC) tests before they are populated with readout modules. One test uses a non-invasive inspection method of infrared (IR) thermal imaging of the heat path while the stave is cooled to around -40°C at ambient room temperature. Imperfections in the manufacturing, such as the delamination of the stave facing from the foam, will exhibit a different temperature profile compared to a flawless stave. We report on the current status of the thermal imaging QC measurements including a characterization of various contributions to the uncertainties in the temperature reading of the IR camera such as pedestal variations, common-mode noise, vignetting, and statistical fluctuations across the field of view.

  2. Phase II study of mifepristone (RU486) in refractory ovarian cancer.

    Science.gov (United States)

    Rocereto, T F; Saul, H M; Aikins, J A; Paulson, J

    2000-06-01

    A phase II study of Mifepristone (RU486) was conducted in patients with ovarian cancer whose tumors were resistant to cisplatin and paclitaxel, alone or in combination. Forty-four patients were accrued into this study. All had ovarian cancer that had become resistant to cisplatin and paclitaxel. Patients received Mifepristone 200 mg orally on a daily basis. Patients were followed by tumor size or CA-125 levels when there was no measurable disease. A dose reduction of Mifepristone was to occur in the event of grade 3/4 hematologic, GI, or liver toxicity, creatinine >2.5%, and grade 4 peripheral neuropathy. Thirty-four patients were evaluable for response. Nine (26.5%) of these patients had a response to Mifepristone. Three(9%) patients had a complete response, and six (17.5%), a partial response. The response of one patient in each group was measured by CA-125 levels while the remainder had measurable disease. The response lasted 1 to 4 months in all but one patient. One patient continues to respond after more than 3 years. The major toxic effect was a rash and this was the major reason patients were removed from the study. Mifepristone has activity against ovarian cancer resistant to cisplatin and paclitaxel. The drug is well tolerated. Further studies need to be performed when this drug becomes more widely available in the United States. Copyright 2000 Academic Press.

  3. Photometric H alpha and [O II] Luminosity Function of SDF and SXDF Galaxies: Implications for Future Baryon Oscillation Surveys

    CERN Document Server

    Sumiyoshi, Masanao; Oshige, Shunsuke; Glazebrook, Karl; Akiyama, Masayuki; Morokuma, Tomoki; Motohara, Kentaro; Shimasaku, Kazuhiro; Hayashi, Masao; Yoshida, Makiko; Kashikawa, Nobunari; Kodama, Tadayuki

    2009-01-01

    Efficient selection of emission line galaxies at z > 1 by photometric information in wide field surveys is one of the keys for future spectroscopic surveys to constrain dark energy using the baryon acoustic oscillation (BAO) signature. Here we estimate the H alpha and [O II] line luminosity functions of galaxies at z = 0.5-1.7 using a novel approach where multi-wavelength imaging data is used to jointly estimate both photometric redshifts and star-formation rates. These photometric estimates of line luminosities at high-redshift use the large data sets of the Subaru Deep Field and Subaru XMM-Newton Deep Field (covering \\sim 1 deg^2) and are calibrated with the spectroscopic data of the local Sloan Digital Sky Survey galaxies. The derived luminosity functions (especially H alpha) are in reasonable agreement with the past estimates based on spectroscopic or narrow-band-filter surveys. This dataset is useful for examining the photometric selection of target galaxies for BAO surveys because of the large cosmologi...

  4. Sejong Open Cluster Survey (SOS). II. IC 1848 Cluster in the H II Region W5 West

    CERN Document Server

    Lim, Beomdu; Kim, Jinyoung S; Bessell, Michael S; Karimov, Rivkat

    2013-01-01

    IC 1848 is one of the young open clusters in the giant star forming Cas OB6 association. Several interesting aspects relating to star formation processes in giant star forming regions attracted us to study the initial mass function (IMF), star formation mode, and properties of pre-main sequence stars (PMS). A UBVI and H alpha photometric study of the young open cluster IC 1848 was conducted as part of the "Sejong Open cluster Survey" (SOS). We have selected 105 early-type members from photometric diagrams. Their mean reddening is = 0.660 +/- 0.054 mag. Using the published photometric data with near- and mid-infrared archival data we confirmed the normal reddening law (R_V = 3.1) toward the cluster (IC 1848). A careful zero-age main sequence fitting gives a distance modulus of V_0 - M_V = 11.7 +/- 0.2 mag, equivalent to 2.2 +/- 0.2 kpc. H alpha photometry and the list of young stellar objects identified by Koenig et al. permitted us to select a large number of PMS stars comprising 196 H alpha emission stars, ...

  5. A phase II randomized trial comparing radiotherapy with concurrent weekly cisplatin or weekly paclitaxel in patients with advanced cervical cancer

    Directory of Open Access Journals (Sweden)

    Charafeddine Maya

    2010-09-01

    Full Text Available Abstract Purpose/Objective This is a prospective comparison of weekly cisplatin to weekly paclitaxel as concurrent chemotherapy with standard radiotherapy for locally advanced cervical carcinoma. Materials/Methods Between May 2000 and May 2004, 31 women with FIGO stage IB2-IVA cervical cancer or with postsurgical pelvic recurrence were enrolled into this phase II study and randomized to receive on a weekly basis either 40 mg/m2 Cisplatin (group I; 16 patients or 50 mg/m2 paclitaxel (group II; 15 patients concurrently with radiotherapy. Median total dose to point A was 74 Gy (range: 66-92 Gy for group I and 66 Gy (range: 40-98 Gy for group II. Median follow-up time was 46 months. Results Patient and tumor characteristics were similar in both groups. The mean number of chemotherapy cycles was also comparable with 87% and 80% of patients receiving at least 4 doses in groups I and II, respectively. Seven patients (44% of group I and 8 patients (53% of group II developed tumor recurrence. The Median Survival time was not reached for Group I and 53 months for group II. The proportion of patients surviving at 2 and 5 years was 78% and 54% for group I and 73% and 43% for group II respectively. Conclusions This small prospective study shows that weekly paclitaxel does not provide any clinical advantage over weekly cisplatin for concurrent chemoradiation for advanced carcinoma of the cervix.

  6. The HST/ACS Coma Cluster Survey : II. Data Description and Source Catalogs

    NARCIS (Netherlands)

    Hammer, Derek; Kleijn, Gijs Verdoes; Hoyos, Carlos; den Brok, Mark; Balcells, Marc; Ferguson, Henry C.; Goudfrooij, Paul; Carter, David; Guzman, Rafael; Peletier, Reynier F.; Smith, Russell J.; Graham, Alister W.; Trentham, Neil; Peng, Eric; Puzia, Thomas H.; Lucey, John R.; Jogee, Shardha; Aguerri, Alfonso L.; Batcheldor, Dan; Bridges, Terry J.; Chiboucas, Kristin; Davies, Jonathan I.; del Burgo, Carlos; Erwin, Peter; Hornschemeier, Ann; Hudson, Michael J.; Huxor, Avon; Jenkins, Leigh; Karick, Arna; Khosroshahi, Habib; Kourkchi, Ehsan; Komiyama, Yutaka; Lotz, Jennifer; Marzke, Ronald O.; Marinova, Irina; Matkovic, Ana; Merritt, David; Miller, Bryan W.; Miller, Neal A.; Mobasher, Bahram; Mouhcine, Mustapha; Okamura, Sadanori; Percival, Sue; Phillipps, Steven; Poggianti, Bianca M.; Price, James; Sharples, Ray M.; Tully, R. Brent; Valentijn, Edwin

    2010-01-01

    The Coma cluster, Abell 1656, was the target of an HST-ACS Treasury program designed for deep imaging in the F475W and F814W passbands. Although our survey was interrupted by the ACS instrument failure in early 2007, the partially completed survey still covers ~50% of the core high-density region in

  7. The HST/ACS Coma Cluster Survey. II. Data Description and Source Catalogs

    NARCIS (Netherlands)

    Hammer, Derek; Verdoes Kleijn, Gijs; Hoyos, Carlos; den Brok, Mark; Balcells, Marc; Ferguson, Henry C.; Goudfrooij, Paul; Carter, David; Guzmán, Rafael; Peletier, Reynier F.; Smith, Russell J.; Graham, Alister W.; Trentham, Neil; Peng, Eric; Puzia, Thomas H.; Lucey, John R.; Jogee, Shardha; Aguerri, Alfonso L.; Batcheldor, Dan; Bridges, Terry J.; Chiboucas, Kristin; Davies, Jonathan I.; del Burgo, Carlos; Erwin, Peter; Hornschemeier, Ann; Hudson, Michael J.; Huxor, Avon; Jenkins, Leigh; Karick, Arna; Khosroshahi, Habib; Kourkchi, Ehsan; Komiyama, Yutaka; Lotz, Jennifer; Marzke, Ronald O.; Marinova, Irina; Matkovic, Ana; Merritt, David; Miller, Bryan W.; Miller, Neal A.; Mobasher, Bahram; Mouhcine, Mustapha; Okamura, Sadanori; Percival, Sue; Phillipps, Steven; Poggianti, Bianca M.; Price, James; Sharples, Ray M.; Tully, R. Brent; Valentijn, Edwin

    2010-01-01

    The Coma cluster, Abell 1656, was the target of an HST-ACS Treasury program designed for deep imaging in the F475W and F814W passbands. Although our survey was interrupted by the ACS instrument failure in early 2007, the partially completed survey still covers ~50% of the core high-density region in

  8. Phase I/II Study of Temozolomide Plus Nimustine Chemotherapy for Recurrent Malignant Gliomas: Kyoto Neuro-oncology Group

    Science.gov (United States)

    AOKI, Tomokazu; ARAKAWA, Yoshiki; UEBA, Tetsuya; ODA, Masashi; NISHIDA, Namiko; AKIYAMA, Yukinori; TSUKAHARA, Tetsuya; IWASAKI, Koichi; MIKUNI, Nobuhiro; MIYAMOTO, Susumu

    2017-01-01

    The objective of this phase I/II study was to examine the efficacy and toxicity profile of temozolomide (TMZ) plus nimustine (ACNU). Patients who had received a standard radiotherapy with one or two previous chemo-regimens were enrolled. In phase I, the maximum-tolerated dose (MTD) by TMZ (150 mg/m2/day) (Day 1–5) plus various doses of ACNU (30, 35, 40, 45 mg/m2/day) (Day 15) per 4 weeks was defined on a standard 3 + 3 design. In phase II, these therapeutic activity and safety of this regimen were evaluated. Forty-nine eligible patients were enrolled. The median age was 50 years-old. Eighty percent had a KPS of 70–100. Histologies were glioblastoma (73%), anaplastic astrocytoma (22%), anaplastic oligodendroglioma (4%). In phase I, 15 patients were treated at four cohorts by TMZ plus ACNU. MTD was TMZ (150 mg/m2) plus ACNU (40 mg/m2). In phase II, 40 patients were treated at the dose of cohort 3 (MTD). Thirty-five percent of patients experienced grade 3 or 4 toxicities, mainly hematologic. The overall response rate was 11% (4/37). Sixty-eight percent (25/37) had stable disease. Twenty-two percent (8/37) showed progression. Progression-free survival (PFS) rates at 6 and 12 months were 24% (95% CI, 12–35%) and 8% (95% CI, 4–15%). Median PFS was 13 months (95% CI, 9.2–17.2 months). Overall survival (OS) at 6 and 12 were 78% (95% CI, 67–89%) and 49% (95% CI, 33–57%). Median OS was 11.8 months (95% CI, 8.2–14.5 months). This phase I/II study showed a moderate toxicity in hematology and may has a promising efficacy in OS, without inferiority in PFS. PMID:27725524

  9. Installation Restoration Program. Phase II. Stage 2. Survey. Edwards AFB, California.

    Science.gov (United States)

    1984-08-01

    confining layers, preventing water within the lower-lying sa-d and gravel layers from rising to its potentiometric level. Figure 2.1 depicts a concep...FURNISPED PROPERTY: None V. GOVERNMENT POT1TS OF CONTACT: 1. Dr Dee Ann Sanders 3. Capt Richard Brewer USAF OEHL/ECQ HQ AFSC/SGPB Brooks AFB TX 78235...or cold vapor generation.) me.a RBsuLm wSN OBTAINEo ey FOLLOWING AcCETAo .UO0RA 40R CEn S.cuouna. (C t< ’ .--- THE[ LIABILIT"Y OFm ME WOOIAi INALL

  10. Mechanisms of Class II correction induced by the crown Herbst appliance as a single-phase Class II therapy: 1 year follow-up.

    Science.gov (United States)

    Jakobsone, Gundega; Latkauskiene, Dalia; McNamara, James A

    2013-09-11

    The objective of this study is to evaluate the skeletal and dentoalveolar effects of the crown Herbst appliance used alone for a single phase of therapy followed by a 1-year observation period. Forty patients (mean age 13.6±1.3 years) with a stable Class I occlusion 1 year following the treatment with the crown Herbst appliance were selected from a prospective sample of 180 consecutively treated Class II patients. No other appliances were used during treatment or during the follow-up period. The dentoskeletal changes were compared with a matched sample of untreated Class II subjects (mean age 13.9±1.6 years). Lateral cephalograms were taken before treatment, after Herbst treatment (1 year), and after 1-year follow-up. Overcorrection was avoided intentionally. Treatment produced an increase in mandibular length, a decrease in ANB angle, and a restriction in the vertical growth of posterior maxilla. The maxillary molars moved backward and tipped distally. The lower incisors proclined markedly, and the upper incisors became retroclined. During the follow-up period, the changes primarily were dentoalveolar in nature, with marked rebound of the upper molars and lower incisors, resulting in some increases in overbite and overjet. The occlusal correction of Class II malocclusion observed 1 year after the crown Herbst appliance as a single-phase therapy was achieved primary due to the dentoalveolar changes and only limited skeletal change occurred.

  11. Final Report: Phase II Nevada Water Resources Data, Modeling, and Visualization (DMV) Center

    Energy Technology Data Exchange (ETDEWEB)

    Jackman, Thomas [Desert Research Institute; Minor, Timothy [Desert Research Institute; Pohll, Gregory [Desert Research Institute

    2013-07-22

    Water is unquestionably a critical resource throughout the United States. In the semi-arid west -- an area stressed by increase in human population and sprawl of the built environment -- water is the most important limiting resource. Crucially, science must understand factors that affect availability and distribution of water. To sustain growing consumptive demand, science needs to translate understanding into reliable and robust predictions of availability under weather conditions that could be average but might be extreme. These predictions are needed to support current and long-term planning. Similar to the role of weather forecast and climate prediction, water prediction over short and long temporal scales can contribute to resource strategy, governmental policy and municipal infrastructure decisions, which are arguably tied to the natural variability and unnatural change to climate. Change in seasonal and annual temperature, precipitation, snowmelt, and runoff affect the distribution of water over large temporal and spatial scales, which impact the risk of flooding and the groundwater recharge. Anthropogenic influences and impacts increase the complexity and urgency of the challenge. The goal of this project has been to develop a decision support framework of data acquisition, digital modeling, and 3D visualization. This integrated framework consists of tools for compiling, discovering and projecting our understanding of processes that control the availability and distribution of water. The framework is intended to support the analysis of the complex interactions between processes that affect water supply, from controlled availability to either scarcity or deluge. The developed framework enables DRI to promote excellence in water resource management, particularly within the Lake Tahoe basin. In principle, this framework could be replicated for other watersheds throughout the United States. Phase II of this project builds upon the research conducted during

  12. Phase II Contaminant Transport Parameters for the Groundwater Flow and Contaminant Transport Model of Corrective Action Unit 98: Frenchman Flat, Nye County, Nevada, Rev. No.: 0

    Energy Technology Data Exchange (ETDEWEB)

    DeNovio, Nicole M.; Bryant, Nathan; King, Chrissi B.; Bhark, Eric; Drellack, Sigmund L.; Pickens, John F.; Farnham, Irene; Brooks, Keely M.; Reimus, Paul; Aly, Alaa

    2005-04-01

    This report documents pertinent transport data and data analyses as part of the Phase II Corrective Action Investigation (CAI) for Frenchman Flat (FF) Corrective Action Unit (CAU) 98. The purpose of this data compilation and related analyses is to provide the primary reference to support parameterization of the Phase II FF CAU transport model.

  13. Phase II Hydrologic Data for the Groundwater Flow and Contaminant Transport Model of Corrective Action Unit 98: Frenchman Flat, Nye County, Nevada, Rev. No.: 0

    Energy Technology Data Exchange (ETDEWEB)

    John McCord

    2004-12-01

    This report documents pertinent hydrologic data and data analyses as part of the Phase II Corrective Action Investigation (CAI) for Frenchman Flat (FF) Corrective Action Unit (CAU): CAU 98. The purpose of this data compilation and related analyses is to provide the primary reference to support the development of the Phase II FF CAU groundwater flow model.

  14. A Study of Employment Demands for Agriculture and Agribusiness in New York State. Phase II Final Report. Res. Pub. 81-01.

    Science.gov (United States)

    Berkey, Arthur L.; And Others

    This final report summarizes Phase II of the study of employment demand data for agriculture/agribusiness in New York State. Analysis, procedures, findings, recommendations, and products of the study are reported. During Phase II, the final eight months of the study, the data collection was completed; procedures were implemented for conducting…

  15. Phase II study of biweekly cetuximab in combination with irinotecan as second-line treatment in patients with platinum-resistant gastro-oesophageal cancer

    DEFF Research Database (Denmark)

    Schønnemann, K R; Yilmaz, Mette Karen; Bjerregaard, J K;

    2012-01-01

    The purpose of this phase II trial was to evaluate the efficacy and safety of cetuximab and irinotecan as second-line treatment in patients with gastro-oesophageal adenocarcinoma.......The purpose of this phase II trial was to evaluate the efficacy and safety of cetuximab and irinotecan as second-line treatment in patients with gastro-oesophageal adenocarcinoma....

  16. Predictors of BMI Vary along the BMI Range of German Adults - Results of the German National Nutrition Survey II.

    Science.gov (United States)

    Moon, Kilson; Krems, Carolin; Heuer, Thorsten; Roth, Alexander; Hoffmann, Ingrid

    2017-01-01

    The objective of the study was to identify predictors of BMI in German adults by considering the BMI distribution and to determine whether the association between BMI and its predictors varies along the BMI distribution. The sample included 9,214 adults aged 18-80 years from the German National Nutrition Survey II (NVS II). Quantile regression analyses were conducted to examine the association between BMI and the following predictors: age, sports activities, socio-economic status (SES), healthy eating index-NVS II (HEI-NVS II), dietary knowledge, sleeping duration and energy intake as well as status of smoking, partner relationship and self-reported health. Age, SES, self-reported health status, sports activities and energy intake were the strongest predictors of BMI. The important outcome of this study is that the association between BMI and its predictors varies along the BMI distribution. Especially, energy intake, health status and SES were marginally associated with BMI in normal-weight subjects; this relationships became stronger in the range of overweight, and were strongest in the range of obesity. Predictors of BMI and the strength of these associations vary across the BMI distribution in German adults. Consequently, to identify predictors of BMI, the entire BMI distribution should be considered. © 2017 The Author(s) Published by S. Karger GmbH, Freiburg.

  17. Predictors of BMI Vary along the BMI Range of German Adults - Results of the German National Nutrition Survey II

    Directory of Open Access Journals (Sweden)

    Kilson Moon

    2017-02-01

    Full Text Available Objective: The objective of the study was to identify predictors of BMI in German adults by considering the BMI distribution and to determine whether the association between BMI and its predictors varies along the BMI distribution. Methods: The sample included 9,214 adults aged 18-80 years from the German National Nutrition Survey II (NVS II. Quantile regression analyses were conducted to examine the association between BMI and the following predictors: age, sports activities, socio-economic status (SES, healthy eating index-NVS II (HEI-NVS II, dietary knowledge, sleeping duration and energy intake as well as status of smoking, partner relationship and self-reported health. Results: Age, SES, self-reported health status, sports activities and energy intake were the strongest predictors of BMI. The important outcome of this study is that the association between BMI and its predictors varies along the BMI distribution. Especially, energy intake, health status and SES were marginally associated with BMI in normal-weight subjects; this relationships became stronger in the range of overweight, and were strongest in the range of obesity. Conclusions: Predictors of BMI and the strength of these associations vary across the BMI distribution in German adults. Consequently, to identify predictors of BMI, the entire BMI distribution should be considered.

  18. The HETDEX Pilot Survey. IV. The Evolution of [O II] Emitting Galaxies from z ~ 0.5 to z ~ 0

    CERN Document Server

    Ciardullo, Robin; Adams, Joshua J; Blanc, Guillermo A; Gebhardt, Karl; Finkelstein, Steven L; Jogee, Shardha; Hill, Gary J; Drory, Niv; Hopp, Ulrich; Schneider, Donald P; Zeimann, Gregory R; Dalton, Gavin B

    2013-01-01

    We present an analysis of the luminosities and equivalent widths of the 284 z < 0.56 [O II]-emitting galaxies found in the 169 square arcmin pilot survey for the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX). By combining emission-line fluxes obtained from the Mitchell spectrograph on the McDonald 2.7-m telescope with deep broadband photometry from archival data, we derive each galaxy's de-reddened [O II] 3727 luminosity and calculate its total star formation rate. We show that over the last ~5 Gyr of cosmic time there has been substantial evolution in the [O II] emission-line luminosity function, with L* decreasing by ~0.6 +/-0.2 dex in the observed function, and by ~0.9 +/-0.2 dex in the de-reddened relation. Accompanying this decline is a significant shift in the distribution of [O II] equivalent widths, with the fraction of high equivalent-width emitters declining dramatically with time. Overall, the data imply that the relative intensity of star formation within galaxies has decreased over th...

  19. Imprints of galaxy evolution on H ii regions Memory of the past uncovered by the CALIFA survey

    CERN Document Server

    Sanchez, S F; Rosales-Ortega, F F; Miralles-Caballero, D; Lopez-Sanchez, A R; Iglesias-Páramo, J; Marino, R A; Sánchez-Menguiano, L; García-Benito, R; Mast, D; Mendoza, M A; Papaderos, P; Ellis, S; Galbany, L; Kehrig, C; Monreal-Ibero, A; Delgado, R González; Mollá, M; Ziegler, B; de Lorenzo-Cáceres, A; Mendez-Abreu, J; Bland-Hawthorn, J; Bekeraite, S; Roth, M M; Pasquali, A; Díaz, A; Bomans, D; van de Ven, G; Wisotzki, L

    2014-01-01

    H ii regions in galaxies are the sites of star formation and thus particular places to understand the build-up of stellar mass in the universe. The line ratios of this ionized gas are frequently used to characterize the ionization conditions. We use the Hii regions catalogue from the CALIFA survey (~5000 H ii regions), to explore their distribution across the classical [OIII]/Hbeta vs. [NII]/Halpha diagnostic diagram, and how it depends on the oxygen abundance, ionization parameter, electron density, and dust attenuation. We compared the line ratios with predictions from photoionization models. Finally, we explore the dependences on the properties of the host galaxies, the location within those galaxies and the properties of the underlying stellar population. We found that the location within the BPT diagrams is not totally predicted by photoionization models. Indeed, it depends on the properties of the host galaxies, their galactocentric distances and the properties of the underlying stellar population. Thes...

  20. Southern Cosmology Survey II: Massive Optically-Selected Clusters from 70 square degrees of the SZE Common Survey Area

    CERN Document Server

    Menanteau, Felipe; Barrientos, L Felipe; Deshpande, Amruta J; Hilton, Matt; Infante, Leopoldo; Jimenez, Raul; Kosowsky, Arthur; Moodley, Kavilan; Spergel, David; Verde, Licia

    2010-01-01

    We present a catalog of 105 rich and massive ($M>3\\times10^{14}M_{\\sun}$) optically-selected clusters of galaxies extracted from 70 square-degrees of public archival griz imaging from the Blanco 4-m telescope acquired over 45 nights between 2005 and 2007. We use the clusters' optically-derived properties to estimate photometric redshifts, optical luminosities, richness, and masses. We complement the optical measurements with archival XMM-Newton and ROSAT X-ray data which provide additional luminosity and mass constraints on a modest fraction of the cluster sample. Two of our clusters show clear evidence for central lensing arcs; one of these has a spectacular large-diameter, nearly-complete Einstein Ring surrounding the brightest cluster galaxy. A strong motivation for this study is to identify the massive clusters that are expected to display prominent signals from the Sunyaev-Zeldovich Effect (SZE) and therefore be detected in the wide-area mm-band surveys being conducted by both the Atacama Cosmology Teles...

  1. Implementation of “PLST” Assessment Model to Detect Development of Language Skill in Early Childhood (Phase II

    Directory of Open Access Journals (Sweden)

    Nelva Rolina

    2015-05-01

    Full Text Available This research will be done for 3 years (3 phases. The first year had been done on 2013 ago. 2014 is the second year of research (phase II. Research phase of this study (second year, namely development phase: the prototype of model is developed to be a model. The activities carried out in phase II include: expert validation test, readability test, revision, kindergarten teacher training, limited trial, and the trial was extended to find models that fit between the theoretical concepts with empirical data in the field. And finally (second year, from all kindergarten which be the sample study, it was found that all kindergarten were using the general assessment without special assessment for development of children’s language, so it is necessary to create assessment “PLST” to detect the development of language skill for early childhood (kindergarten student. It has to continue in second to third year. The final research, which is at the end of the third year (phase III is expected to match model assessment “PLST” as well as the guidance in learning in kindergarten, which can be used by teachers to detect and monitor the development of language skills, identifying the amount of vocabulary and sentences are mastered children, and the stages of language development next. To achieve these objectives, the researcher adopted a model of research, development, and diffusion by Hopkins & Clark (Havelock, 1976

  2. Review of phase I and II trials for Wilms' tumour - Can we optimise the search for novel agents?

    Science.gov (United States)

    Brok, Jesper; Pritchard-Jones, Kathy; Geller, James I; Spreafico, Filippo

    2017-07-01

    Survival rates for patients with Wilms' tumour (WT) approximate 90% with refined use of currently available interventions. However, a subgroup of patients, with initial high-risk histopathology or relapsing disease, have a poor prognosis, and it is a challenge to identify and prioritise the development of new innovative approaches for these subgroups. We conducted a systematic literature search for published phase I and II clinical trials that registered patients with WTs and characterised the early phase trial activity, quantified response rates and highlighted avenues for further development. We identified 63 trials (48 phase I, three phase I/II, and 12 phase II trials) enrolling 214 patients with WTs, alongside other malignancies. The number of annually recruited WTs did not change significantly and was less than 20% of the potential candidates. The vast majority of the trials were conducted in North America, and 56 different interventions were investigated, including conventional chemotherapy and biologically targeted therapies. Overall, 33 WTs revealed some degree of tumour control. Of these, five patients demonstrated complete remission (2%), 15 patients partial response (7%) and 13 patients stable disease (6%). None of the included novel biologically targeted therapies emerged as promising interventions, and only conventional chemotherapy was able to induce a complete and partial response. We conclude that early phase trial recruitment of WTs is below expected levels, and the clinical outcome of the included patients is dismal. Improvement of the availability and recruitment to early phase trials for WTs, especially in Europe, is needed. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Liquid phase sintering, II: Computer study of skeletal settling and solid phase extrication in a microgravity environment

    Directory of Open Access Journals (Sweden)

    Nikolić Z.S.

    2008-01-01

    Full Text Available A two-dimensional numerical method based on the Brownian motion model and on the Densification model for simulation of liquid phase sintering in microgravity environment will be developed. Both models will be based on domain topology (two-dimensional particle representation and control volume methodology and on three submodels for domain translation, solid skeleton formation and domain extrication. This method will be tested in order to conduct a study of diffusion phenomena and microgravitational effects on microstructural evolution influenced by skeletal settling combined with solid-phase extrication during liquid phase sintering of porous W-Ni system.

  4. Level II contamiant survey of the Tallahatchie National Wildlife Refuge, Quitman, Tallahatchie, and Grenada Counties, Mississippi

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Report contains findings of tissue and sediment samples for organic and inorganic contaminants as part of a preaquistion survey for Tallahatchie NWR. Elevated levels...

  5. Exploring the statistical and clinical impact of two interim analyses on the Phase II design with option for direct assignment.

    Science.gov (United States)

    An, Ming-Wen; Mandrekar, Sumithra J; Edelman, Martin J; Sargent, Daniel J

    2014-07-01

    The primary goal of Phase II clinical trials is to understand better a treatment's safety and efficacy to inform a Phase III go/no-go decision. Many Phase II designs have been proposed, incorporating randomization, interim analyses, adaptation, and patient selection. The Phase II design with an option for direct assignment (i.e. stop randomization and assign all patients to the experimental arm based on a single interim analysis (IA) at 50% accrual) was recently proposed [An et al., 2012]. We discuss this design in the context of existing designs, and extend it from a single-IA to a two-IA design. We compared the statistical properties and clinical relevance of the direct assignment design with two IA (DAD-2) versus a balanced randomized design with two IA (BRD-2) and a direct assignment design with one IA (DAD-1), over a range of response rate ratios (2.0-3.0). The DAD-2 has minimal loss in power (assignment design, especially with two IA, provides a middle ground with desirable statistical properties and likely appeal to both clinicians and patients. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. High-velocity streams in the Milky Way halo with the SDSS and GSC-II kinematic survey

    Directory of Open Access Journals (Sweden)

    Spagna A.

    2012-02-01

    Full Text Available We explore the stellar halo of the Milky Way to search for fossil signatures of past mergers, consisting of streams of particles torn from their progenitors during the process of hierarchical merging. We examine a representative sample of about 2 700 halo subdwarfs in the solar neighborhood, selected from a new kinematic survey produced by means of spectrophotometric data from the Sloan Digital Sky Survey, and high-quality proper motions derived from multi-epoch positions using the Guide Star Catalog II. We find statistical evidence for discrete overdensities, likely possible accretion remnants. This methodology and the quality of the selected sample are an efficient means to discover new members of known streams and to identify new streams themselves, and set the basis for future studies.

  7. Galactic bulge population II Cepheids in the VVV survey: period-luminosity relations and a distance to the Galactic centre

    Science.gov (United States)

    Bhardwaj, A.; Rejkuba, M.; Minniti, D.; Surot, F.; Valenti, E.; Zoccali, M.; Gonzalez, O. A.; Romaniello, M.; Kanbur, S. M.; Singh, H. P.

    2017-09-01

    Context. Multiple stellar populations of different ages and metallicities reside in the Galactic bulge that trace its structure and provide clues to its formation and evolution. Aims: We present the near-infrared observations of population II Cepheids in the Galactic bulge from VISTA Variables in the Vía Láctea (VVV) survey. The JHKs photometry together with optical data from Optical Gravitational Lensing Experiment (OGLE) survey provide an independent estimate of the distance to the Galactic centre. The old, metal-poor and low-mass population II Cepheids are also investigated as useful tracers for the structure of the Galactic bulge. Methods: We identify 340 population II Cepheids in the VVV survey Galactic bulge catalogue based on their match with the OGLE-III Catalogue. The single-epoch JH and multi-epoch Ks observations complement the accurate periods and optical (VI) mean-magnitudes from OGLE. The sample consisting of BL Herculis and W Virginis subtypes is used to derive period-luminosity relations after correcting mean-magnitudes for the extinction. Our Ks-band period-luminosity relation, Ks = -2.189(0.056) [log (P)-1] + 11.187(0.032), is consistent with published work for BL Herculis and W Virginis variables in the Large Magellanic Cloud. Results: We present a combined OGLE-III and VVV catalogue with periods, classification, mean magnitudes, and extinction for 264 Galactic bulge population II Cepheids that have good-quality Ks-band light curves. The absolute magnitudes for population II Cepheids and RR Lyraes calibrated using Gaia and Hubble Space Telescope parallaxes, together with calibrated magnitudes for Large Magellanic Cloud population II Cepheids, are used to obtain a distance to the Galactic centre, R0 = 8.34 ± 0.03(stat.) ± 0.41(syst.), which changes by with different extinction laws. While noting the limitation of small number statistics, we find that the present sample of population II Cepheids in the Galactic bulge shows a nearly spheroidal

  8. A survey on control schemes for distributed solar collector fields. Part II: Advanced control approaches

    Energy Technology Data Exchange (ETDEWEB)

    Camacho, E.F.; Rubio, F.R. [Universidad de Sevilla, Escuela Superior de Ingenieros, Departamento de Ingenieria de Sistemas y Automatica, Camino de Los Descubrimientos s/n, E-41092 Sevilla (Spain); Berenguel, M. [Universidad de Almeria, Departamento de Lenguajes y Computacion, Area de Ingenieria de Sistemas y Automatica, Carretera Sacramento s/n, E-04120 La Canada, Almeria (Spain); Valenzuela, L. [Plataforma Solar de Almeria - CIEMAT, Carretera Senes s/n, P.O. Box 22, E-04200 Tabernas (Almeria) (Spain)

    2007-10-15

    This article presents a survey of the different advanced automatic control techniques that have been applied to control the outlet temperature of solar plants with distributed collectors during the last 25 years. A classification of the modeling and control approaches described in the first part of this survey is used to explain the main features of each strategy. The treated strategies range from classical advanced control strategies to those with few industrial applications. (author)

  9. Report on the Council of Graduate Schools-Graduate Record Examinations Board 1981-82 Survey of Graduate Enrollment, Part II, June 1982.

    Science.gov (United States)

    Cox, Virginia B.; Khoury, Bernard V.

    Results of the Council of Graduate Schools-Graduate Record Examinations Board 1981-1982 Survey of Graduate Enrollment, Part II are presented, based on usable responses from 299 institutions. The survey findings provide information about changes in the pattern of graduate school enrollment and allow comparisons between public and private…

  10. The WIRED Survey II: Infrared Excesses in the SDSS DR7 White Dwarf Catalog

    CERN Document Server

    Debes, J H; Wachter, S; Leisawitz, D T; Cohen, M

    2011-01-01

    With the launch of the {\\em Wide-field Infrared Survey Explorer} ({\\em WISE}), a new era of detecting planetary debris and brown dwarfs around white dwarfs (WDs) has begun with the {\\em WISE} InfraRed Excesses around Degenerates (WIRED) Survey. The WIRED Survey is sensitive to substellar objects and dusty debris around WDs out to distances exceeding 100 pc, well beyond the completeness level of local WDs. In this paper, we present a cross-correlation of the preliminary Sloan Digital Sky Survey (SDSS) Data Release 7 (DR7) WD Catalog between the {\\em WISE}, Two-Micron All Sky Survey (2MASS), UKIRT Infrared Deep Sky Survey (UKIDSS), and SDSS DR7 photometric catalogs. From $\\sim18,000$ input targets, there are {\\em WISE} detections comprising 344 "naked" WDs (detection of the WD photosphere only), 1020 candidate WD+M dwarf binaries, 42 candidate WD+brown dwarf (BD) systems, 52 candidate WD+dust disk systems, and 69 targets with indeterminate infrared excess. We classified all of the detected targets through spect...

  11. Nimotuzumab combined with radiotherapy for esophageal cancer: preliminary study of a Phase II clinical trial

    Directory of Open Access Journals (Sweden)

    Liang J

    2013-11-01

    Full Text Available Jun Liang,1 Mingyan E,2 Gang Wu,3 Lujun Zhao,4 Xia Li,5 Xia Xiu,6 Ning Li,1 Bo Chen,1 Zhouguang Hui,1 Jima Lv,1 Hui Fang,1 Yu Tang,1 Nan Bi,1 Wenqing Wang,1 Yirui Zhai,1 Tao Li,1 Dongfu Chen,1 Shuangmei Zou,7 Ning Lu,7 Rolando Perez-Rodríguez,8 Junqi Zheng,9 Luhua Wang11Department of Radiotherapy, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; 2Department of Radiotherapy, Cancer Hospital of Harbin Medical University, Harbin, People's Republic of China; 3Department of Radiotherapy, Tongji Cancer Center Hospital, Wuhan, People's Republic of China; 4Department of Radiotherapy, Cancer Hospital of Tianjin Medical University, Tianjin, People's Republic of China; 5Department of Radiotherapy, LiaoNing Province Cancer Hospital, Shenyang, People's Republic of China; 6Department of Radiotherapy, Beijing Hospital, Beijing, People's Republic of China; 7Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; 8Center of Molecular Immunology, Havana, Cuba; 9School of Medicine, Tongji University, Shanghai, People's Republic of ChinaObjective: To determine the safety and therapeutic effects of nimotuzumab (h-R3 combined with radiotherapy in esophageal cancer.Methods: This Phase II clinical trial involved 42 patients with stage II (inoperable or refused surgery to stage IV (supraclavicular lymph node metastasis only esophageal cancers treated between November 2008 and July 2010. All patients had squamous cell carcinomas, and all received three-dimensional conformal radiotherapy and 200 mg nimotuzumab per week during radiotherapy.Results: There were 9, 25, and 8 patients with stage II, III and IV disease, respectively. All except two patients received 50–70 Gy radiation; 37 patients (88.1% received more than five nimotuzumab doses. Grade III toxicities (21.4% of all adverse events included esophagitis and gastrointestinal, dermatological and hematological

  12. Radiative forcing of the direct aerosol effect from AeroCom Phase II simulations

    Science.gov (United States)

    Myhre, G.; Samset, B. H.; Schulz, M.; Balkanski, Y.; Bauer, S.; Berntsen, T. K.; Bian, H.; Bellouin, N.; Chin, M.; Diehl, T.; Easter, R. C.; Feichter, J.; Ghan, S. J.; Hauglustaine, D.; Iversen, T.; Kinne, S.; Kirkevåg, A.; Lamarque, J.-F.; Lin, G.; Liu, X.; Lund, M. T.; Luo, G.; Ma, X.; van Noije, T.; Penner, J. E.; Rasch, P. J.; Ruiz, A.; Seland, Ø.; Skeie, R. B.; Stier, P.; Takemura, T.; Tsigaridis, K.; Wang, P.; Wang, Z.; Xu, L.; Yu, H.; Yu, F.; Yoon, J.-H.; Zhang, K.; Zhang, H.; Zhou, C.

    2013-02-01

    We report on the AeroCom Phase II direct aerosol effect (DAE) experiment where 16 detailed global aerosol models have been used to simulate the changes in the aerosol distribution over the industrial era. All 16 models have estimated the radiative forcing (RF) of the anthropogenic DAE, and have taken into account anthropogenic sulphate, black carbon (BC) and organic aerosols (OA) from fossil fuel, biofuel, and biomass burning emissions. In addition several models have simulated the DAE of anthropogenic nitrate and anthropogenic influenced secondary organic aerosols (SOA). The model simulated all-sky RF of the DAE from total anthropogenic aerosols has a range from -0.58 to -0.02 Wm-2, with a mean of -0.27 Wm-2 for the 16 models. Several models did not include nitrate or SOA and modifying the estimate by accounting for this with information from the other AeroCom models reduces the range and slightly strengthens the mean. Modifying the model estimates for missing aerosol components and for the time period 1750 to 2010 results in a mean RF for the DAE of -0.35 Wm-2. Compared to AeroCom Phase I (Schulz et al., 2006) we find very similar spreads in both total DAE and aerosol component RF. However, the RF of the total DAE is stronger negative and RF from BC from fossil fuel and biofuel emissions are stronger positive in the present study than in the previous AeroCom study. We find a tendency for models having a strong (positive) BC RF to also have strong (negative) sulphate or OA RF. This relationship leads to smaller uncertainty in the total RF of the DAE compared to the RF of the sum of the individual aerosol components. The spread in results for the individual aerosol components is substantial, and can be divided into diversities in burden, mass extinction coefficient (MEC), and normalized RF with respect to AOD. We find that these three factors give similar contributions to the spread in results.

  13. Physician refer thyself: is Stark II, phase III the final voyage?

    Science.gov (United States)

    Manchikanti, Laxmaiah; McMahon, Erin Brisbay

    2007-11-01

    , the Stark I prohibition on self-referrals by physicians expanded to include 10 additional healthcare services known as designated health services or DHS. The 1993 expansion of Stark I was enacted in 1995 as Stark II. In 2007, CMS adopted Phase III of the regulations interpreting Stark II. Phase III made multiple changes and clarified many previous issues, and it becomes effective December 4, 2007. While it is mandatory to obtain expert legal advice and this manuscript in no way provides the extensive navigation required through the maze of Stark laws and other anti-kickback statutes, it is incumbent on interventionalists in all settings of practice to have appropriate knowledge of the Stark laws and exceptions and of the anti-kickback statute and safe harbors. Penalties for violating the Stark laws are severe, including fines of up to dollars 15,000 per service and the economic threat of exclusion from participation in federal healthcare programs, which may result in exclusion of any type of healthcare program and loss of privileges at hospitals and surgery centers. This manuscript reviews physician practices in general, physician payments, and self-referral patterns in particular, the evolution of the Stark law and regulations and its implications for physician practices. This article is not, and should not be, construed as legal advice or an opinion on specific situations.

  14. Environmental monitoring survey of oil and gas fields in Region II in 2009. Summary report; Miljoeovervaaking av olje- og gassfelt i Region II i 2009. Sammendragsrapport

    Energy Technology Data Exchange (ETDEWEB)

    2010-03-15

    The oil companies Statoil ASA, ExxonMobil Exploration and Production Norway AS, Total E&P Norge AS, Talisman Energy Norge AS and Marathon Petroleum Norge AS commissioned Section of Applied Environmental Research at UNI RESEARCH AS to undertake the monitoring survey of Region II in 2009. Similar monitoring surveys in Region II have been carried out in 1996, 2000, 2003 and 2006. The survey in 2009 included in total 18 fields: Rev, Varg, Sigyn, Sleipner Vest, Sleipner Oest, Sleipner Alfa Nord, Glitne, Grane, Balder, Ringhorne, Jotun, Vale, Skirne, Byggve, Heimdal, Volve, Vilje og Alvheim. Sampling was conducted from the vessel MV Libas between May 18 and May 27. Samples were collected from in totally 137 sampling sites, of which 15 were regional sampling sites. Samples for chemical analysis were collected at all sites, whereas samples for benthos analysis were collected at 12 fields. As in previous surveys, Region II is divided into natural sub-regions. One sub-region is shallow (77-96 m) sub-region, a central sub-region (107-130 m) and a northern subregion (115-119 m). The sediments of the shallow sub-region had relatively lower content of TOM and pelite and higher content of fine sand than the central and northern sub-regions. Calculated areas of contamination are shown for the sub-regions in Table 1.1. The fields Sigyn, Sleipner Alfa Nord, Glitne, Grane, Balder, Ringhorne, Jotun, Skirne, Byggve, Vilje og Alvheim showed no contamination of THC. At the other fields there were minor changes from 2006. The concentrations of barium increased in the central sub-region from 2006 to 2009, also at fields where no drilling had been undertaken during the last years. The same laboratory and methods are used during the three last regional investigations. The changes in barium concentrations may be due to high variability of barium concentrations in the sediments. This is supported by relatively large variations in average barium concentrations at the regional sampling sites in

  15. Environmental monitoring survey of oil and gas fields in Region II in 2009. Summary report; Miljoeovervaaking av olje- og gassfelt i Region II i 2009

    Energy Technology Data Exchange (ETDEWEB)

    2010-03-15

    The oil companies Statoil ASA, ExxonMobil Exploration and Production Norway AS, Total E&P Norge AS, Talisman Energy Norge AS and Marathon Petroleum Norge AS commissioned Section of Applied Environmental Research at UNI RESEARCH AS to undertake the monitoring survey of Region II in 2009. Similar monitoring surveys in Region II have been carried out in 1996, 2000, 2003 and 2006. The survey in 2009 included in total 18 fields: Rev, Varg, Sigyn, Sleipner Vest, Sleipner OEst, Sleipner Alfa Nord, Glitne, Grane, Balder, Ringhorne, Jotun, Vale, Skirne, Byggve, Heimdal, Volve, Vilje og Alvheim. Sampling was conducted from the vessel MV Libas between May 18 and May 27. Samples were collected from in totally 137 sampling sites, of which 15 were regional sampling sites. Samples for chemical analysis were collected at all sites, whereas samples for benthos analysis were collected at 12 fields. As in previous surveys, Region II is divided into natural sub-regions. One sub-region is shallow (77-96 m) sub-region, a central sub-region (107-130 m) and a northern subregion (115-119 m). The sediments of the shallow sub-region had relatively lower content of TOM and pelite and higher content of fine sand than the central and northern sub-regions. Calculated areas of contamination are shown for the sub-regions in Table 1.1. The fields Sigyn, Sleipner Alfa Nord, Glitne, Grane, Balder, Ringhorne, Jotun, Skirne, Byggve, Vilje og Alvheim showed no contamination of THC. At the other fields there were minor changes from 2006. The concentrations of barium increased in the central sub-region from 2006 to 2009, also at fields where no drilling had been undertaken during the last years. The same laboratory and methods are used during the three last regional investigations. The changes in barium concentrations may be due to high variability of barium concentrations in the sediments. This is supported by relatively large variations in average barium concentrations at the regional sampling sites in

  16. Action of Halowax 1051 on Enzymes of Phase I (CYP1A1 and Phase II (SULT1A and COMT Metabolism in the Pig Ovary

    Directory of Open Access Journals (Sweden)

    Justyna Barć

    2013-01-01

    Full Text Available Polychlorinated naphthalenes (PCNs are a group of organochlorinated compounds exhibiting dioxin-like properties. Previously published data showed the direct action of PCN-rich Halowax 1051 on ovarian follicular steroidogenesis. Taking into consideration that the observed biological effects of PCNs may be frequently side effects of metabolites generated by their detoxification, the aim of this study was to determine the activity and expression of enzymes involved in phase I (cytochrome P450, family 1 (CYP1A1 and phase II (sulfotransferase (SULT1A and catechol-O-methyltransferase (COMT detoxification metabolism. Cocultures of granulosa and theca interna cells collected from sexually mature pigs were exposed to 1 pg/mL to 10 ng/mL of Halowax 1051 for 1 to 48 hours, after which levels and activities of CYP1A1, SULT1A, and COMT were measured. Dose-dependent increases of CYP1A1 activity and expression were observed. High doses of Halowax 1051 were inhibitory to COMT and SULT1A activity and reduced their protein levels. In conclusion, fast activation of phase I enzymes with simultaneous inhibition of phase II enzymes indicates that the previously observed effect of Halowax 1051 on follicular steroidogenesis may partially result from metabolite action occurring locally in ovarian follicles.

  17. Mass spectrometric evaluation of mephedrone in vivo human metabolism: identification of phase I and phase II metabolites, including a novel succinyl conjugate.

    Science.gov (United States)

    Pozo, Óscar J; Ibáñez, María; Sancho, Juan V; Lahoz-Beneytez, Julio; Farré, Magí; Papaseit, Esther; de la Torre, Rafael; Hernández, Félix

    2015-02-01

    In recent years, many new designer drugs have emerged, including the group of cathinone derivatives. One frequently occurring drug is mephedrone; although mephedrone was originally considered as a "legal high" product, it is currently banned in most Western countries. Despite the banning, abuse of the drug and seizures are continuously reported. Although the metabolism of mephedrone has been studied in rats or in vitro using human liver microsomes, to the best of our knowledge, no dedicated study with human volunteers has been performed for studying the in vivo metabolism of mephedrone in humans. Therefore, the aim of this study was to establish the actual human metabolism of mephedrone and to compare it with other models. For this purpose, urine samples of two healthy volunteers, who ingested 200 mg mephedrone orally, were taken before administration and 4 hours after substance intake. The discovery and identification of the phase I and phase II metabolites of mephedrone were based on ultra-high-performance liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry, operating in the so-called MS(E) mode. Six phase I metabolites and four phase II metabolites were identified, four of them not previously reported in the literature. The structure of four of the detected metabolites was confirmed by synthesis of the suggested compounds. Remarkably, a mephedrone metabolite conjugated with succinic acid has been identified and confirmed by synthesis. According to the reviewed literature, this is the first time that this type of conjugate is reported for human metabolism.

  18. Causalities between CO{sub 2}, electricity, and other energy variables during phase I and phase II of the EU ETS

    Energy Technology Data Exchange (ETDEWEB)

    Keppler, Jan Horst [Professor of Economics, CGEMP, Universite Paris-Dauphine, Place du Marechal de Lattre de Tassigny, 75775 Paris Cedex 16 (France); Mansanet-Bataller, Maria [CDC Climat Research and University of Valencia, Faculty of Economics, Department of Financial Economics, Av Tarongers s/n 46022 Valencia (Spain)

    2010-07-15

    The topic of this article is the analysis of the interplay between daily carbon, electricity and gas price data with the European Union Emission Trading System (EU ETS) for CO{sub 2} emissions. In a first step we have performed Granger causality tests for Phase I of the EU ETS (January 2005 until December 2007) and the first year of Phase II of the EU ETS (2008). The analysis includes both spot and forward markets - given the close interactions between the two sets of markets. The results show that during Phase I coal and gas prices, through the clean dark and spark spread, impacted CO{sub 2} futures prices, which in return Granger caused electricity prices. During the first year of the Phase II, the short-run rent capture theory (in which electricity prices Granger cause CO{sub 2} prices) prevailed. On the basis of the qualitative results of the Granger causality tests we obtained the formulation testable equations for quantitative analysis. Standard OLS regressions yielded statistically robust and theoretically coherent results. (author)

  19. Offshore Code Comparison Collaboration, Continuation: Phase II Results of a Floating Semisubmersible Wind System: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Robertson, A.; Jonkman, J.; Musial, W.; Vorpahl, F.; Popko, W.

    2013-11-01

    Offshore wind turbines are designed and analyzed using comprehensive simulation tools that account for the coupled dynamics of the wind inflow, aerodynamics, elasticity, and controls of the turbine, along with the incident waves, sea current, hydrodynamics, and foundation dynamics of the support structure. The Offshore Code Comparison Collaboration (OC3), which operated under the International Energy Agency (IEA) Wind Task 23, was established to verify the accuracy of these simulation tools [1]. This work was then extended under the Offshore Code Comparison Collaboration, Continuation (OC4) project under IEA Wind Task 30 [2]. Both of these projects sought to verify the accuracy of offshore wind turbine dynamics simulation tools (or codes) through code-to-code comparison of simulated responses of various offshore structures. This paper describes the latest findings from Phase II of the OC4 project, which involved the analysis of a 5-MW turbine supported by a floating semisubmersible. Twenty-two different organizations from 11 different countries submitted results using 24 different simulation tools. The variety of organizations contributing to the project brought together expertise from both the offshore structure and wind energy communities. Twenty-one different load cases were examined, encompassing varying levels of model complexity and a variety of metocean conditions. Differences in the results demonstrate the importance and accuracy of the various modeling approaches used. Significant findings include the importance of mooring dynamics to the mooring loads, the role nonlinear hydrodynamic terms play in calculating drift forces for the platform motions, and the difference between global (at the platform level) and local (at the member level) modeling of viscous drag. The results from this project will help guide development and improvement efforts for these tools to ensure that they are providing the accurate information needed to support the design and

  20. Enhancing physical activity in older adults receiving hospital based rehabilitation: a phase II feasibility study

    Directory of Open Access Journals (Sweden)

    Said Catherine M

    2012-06-01

    Full Text Available Abstract Background Older adults receiving inpatient rehabilitation have low activity levels and poor mobility outcomes. Increased physical activity may improve mobility. The objective of this Phase II study was to evaluate the feasibility of a randomized controlled trial (RCT of enhanced physical activity in older adults receiving rehabilitation. Methods Patients admitted to aged care rehabilitation with reduced mobility were randomized to receive usual care or usual care plus additional physical activity, which was delivered by a physiotherapist or physiotherapy assistant. The feasibility and safety of the proposed RCT protocol was evaluated. The primary clinical outcome was mobility, which was assessed on hospital admission and discharge by an assessor blinded to group assignment. To determine the most appropriate measure of mobility, three measures were trialled; the Timed Up and Go, the Elderly Mobility Scale and the de Morton Mobility Index. Results The protocol was feasible. Thirty-four percent of people admitted to the ward were recruited, with 47 participants randomised to a control (n = 25 or intervention group (n = 22. The rates of adverse events (death, falls and readmission to an acute service did not differ between the groups. Usual care therapists remained blind to group allocation, with no change in usual practice. Physical activity targets were met on weekdays but not weekends and the intervention was acceptable to participants. The de Morton Mobility Index was the most appropriate measure of mobility. Conclusions The proposed RCT of enhanced physical activity in older adults receiving rehabilitation was feasible. A larger multi-centre RCT to establish whether this intervention is cost effective and improves mobility is warranted. Trial registration The trial was registered with the ANZTCR (ACTRN12608000427370.