WorldWideScience

Sample records for surrey tw20 0ex

  1. Silicon photonics at the University of Surrey

    Science.gov (United States)

    Reed, G. T.; Mashanovich, G.; Gardes, F. Y.; Gwilliam, R. M.; Wright, N. M.; Thomson, D. J.; Timotijevic, B. D.; Litvinenko, K. L.; Headley, W. R.; Smith, A. J.; Knights, A. P.; Jessop, P. E.; Tarr, N. G.; Deane, J. H. B.

    2009-05-01

    Silicon Photonics is a field that has seen rapid growth and dramatic changes in the past 5 years. According to the MIT Communications Technology Roadmap [1], which aims to establish a common architecture platform across market sectors with a potential $20B in annual revenue, silicon photonics is among the top ten emerging technologies. This has in part been a consequence of the recent involvement of large semiconductor companies around the world, particularly in the USA. Significant investment in the technology has also followed in Japan, Korea, and in the European Union. Low cost is a key driver, so it is imperative to pursue technologies that are mass-producible. Therefore, Silicon Photonics continues to progress at a rapid rate. This paper will describe some of the work of the Silicon Photonics Group at the University of Surrey in the UK. The work is concerned with the sequential development of a series of components for silicon photonic optical circuits, and some of the components are discussed here. In particular the paper will present work on optical waveguides, optical filters, modulators, and lifetime modification of carriers generated by two photon absorption, to improve the performance of Raman amplifiers in silicon.

  2. Biomass heating at East Surrey Hospital: technical evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Landen, R; Rippengal, R

    2000-07-01

    This report provides the results of a detailed evaluation of the proposed biomass heating installation at East Surrey Hospital. It is intended to allow the Trust to make a decision on whether to proceed further with the scheme and, if so, on what basis. Specific areas assessed and reported on include: existing services provision for heating and cooling; technical aspects of the proposed biomass scheme; commercial aspects of the proposed biomass scheme. (author)

  3. North West Surrey's locality hubs - delivering integrated care

    OpenAIRE

    Compton, Lisa; Wilkinson, Peter; Lawn, Liz

    2017-01-01

    Introduction: North West Surrey CCG (NWSCCG) is establishing Locality Hubs – physical buildings offering a fully integrated GP-led, multi-disciplinary ‘one-stop-shop’ services in the community for a defined cohort of frail elderly patients with multiple core morbidities. Hubs will ultimately deliver proactive and reactive care, available 24 hours a day, 365 days a year.The key drivers are;Ageing population, people living longer & more people living with chronic conditionsCost & demand...

  4. District of Surrey automated energy mangement project report

    Energy Technology Data Exchange (ETDEWEB)

    1984-01-01

    In November 1981, the Municipality of Surrey was given a contract; under the Canada/British Columbia conservation and renewable energy demonstration agreement, to install a computerized building energy management system (BMS) at a central location with which to monitor and control the energy use in separate and different civic facilities via telephone lines (wireless links would have been feasible). The demonstration had three objectives: to establish the feasibility of centralized control via telephone lines, to collect energy performance data and thus, to determine the effectiveness of a BMS, and to reduce the energy costs to the municipal government. A Johnson Control JC/85/10 energy management computer was connected to seven separate buildings via telephone lines. The buildings represent 5 building types: 2 libraries, 3 swimming pools, 1 municipal office buildiing, 1 court house, and 1 low enforcement building. It took almost 6 months for the BMS to be fully installed in the facilities and an additional 6 months to fix it. An independent consultant was hired to evaluate the performance of the system in each building and thus, to determine its cost-effectiveness. Two periods of energy use were compared in the evaluation: May 1981 to April 1982 was the base year and September 1982 to August 1983 the demonstration year. The BMS was installed for a total cpital cost af about $123,000 and produced a first year energy cost savings of $38,600, yielding an average simple payback of 3.2 years. It was concluded that the demonstration was successful, and it is recommended that the federal governmnent provide further support to BMS demonstrations. 8 tabs.

  5. A 10-year review of the dose history of radiation workers in the University of Surrey

    International Nuclear Information System (INIS)

    Parami, V.K.

    1991-09-01

    This thesis presents data on internally and externally received doses for radiation workers whose records are kept at the Safety Office of the University of Surrey for the period 1981-1990. The distribution of doses by range is presented and analysed. The patterns of the collective equivalent dose (CED) and the average individual equivalent dose (IED) over the 10-year period are presented. The annual CED is very low, so that even the total for the 10-year period is less than 1 man-Sv. Likewise, the annual average IED is extremely low, well below the average annual dose to the U.K. population from overall sources of ionising radiation. Some relevant aspects of the 1990 ICRP Recommendations are examined and the impact of these to the 'practices' and sources of ionising radiation in the University is given consideration. The results of the 10-year review provide more evidence of over designation of radiation workers in the University. A recommendation is made to reduce the number of workers who are routinely monitored and justification and options are presented. This study is viewed as a useful database which could be of particular importance in the procedure of optimisation of radiation protection in the University of Surrey and U.K. establishments for higher education as a whole. (author)

  6. Surrey Ion Beam Centre: the EPSRC MRF for ion beam applications - 01002

    International Nuclear Information System (INIS)

    Webb, R.P.

    2016-01-01

    The SIBC (Surrey Ion Beam Centre) is an element of the Virtual Ion Beam Centre that coordinates 3 U.K. experimental facilities: SIBC (University of Surrey) for implantation and ion beam applications, Miami and MEIS facility (University of Huddersfield) and gamma ray and neutron irradiation emulation facility (University of Manchester). The SIBC works actively with industry, developing bespoke processes and services, particularly for the photonics industry and provides ion beam facilities to about 20 companies across the world. It operates a stringent quality control program and is one of the few ion beam laboratories in the world to operate under ISO 9001 certification. The equipment of SIBC is presented and some applications of ion beam analysis concerning the identification of gunshot residues, the determination of the origin of a painting, the analysis of proteins are described. Different techniques such as PIXE (Particle Induced X-ray Emission), RBS (Rutherford Backscattering Spectroscopy), NRA (Nuclear Reaction Analysis), SIMS (Secondary Ion Mass Spectrometry) are also explained in the slides of the presentation that have been added at the end of the paper

  7. Multicultural Arts Education in the Post-Secondary Context?: Creating Installation and Performance Art in Surrey, Canada

    Science.gov (United States)

    Colby, Sasha

    2011-01-01

    In 2007, Simon Fraser University's satellite campus in Surrey, British Columbia, received an Official Languages Dissemination Grant from the Social Sciences and Humanities Research Council of Canada to examine the role of official bilingualism in the multilingual context through installation and performance art. This essay considers the processes…

  8. Turkey BILSAT-1: a Case Study for the Surrey Know-How Transfer and Training Program

    Science.gov (United States)

    Ghafoor, Nadeem; Murat Leloglu, Ugur; Sweeting, Martin, , Sir

    2002-01-01

    Surrey has established itself over the past 18 years as a world leader in providing hands-on spacecraft engineering training through its Small Satellite Engineering Know-How Transfer and Training (`KHTT') programme. This 18- month course runs alongside the construction of a microsatellite executed through SSTL, and strikes a balance between classroom-based teaching and total immersion within professional engineering teams. Hands-on training is provided covering the entire satellite engineering process, from mission and subsystem design, through module manufacture, assembly and integration, to qualification and flight model environmental tests, launch and commissioning. SSTL's experience in providing the KHTT programme has resulted in a well-defined course structure that yet retains the ability to accommodate individual customer requirements. The programme also takes full advantage of SSTL's intrinsic link with the Surrey Space Centre (`SSC') at the University of Surrey, offering a range of MSc and PhD research programmes pursuing common research interests of both SSTL and the customer, and in many cases complementing the development of either the customer's satellite or their future plans for an evolved space capability. Throughout 2002, three KHTT programmes have run in parallel at SSTL. A team of 11 engineers from the Centre Nationale des Techniques Spatiales in Algeria have now reached completion of their programme with Alsat-1, the first enhanced microsatellite of the Disaster Monitoring Constellation (`DMC'). In December 2001, 15 engineers from the Federal Ministry of Science and Technology in Nigeria arrived at SSTL and are now midway through their programme with Nigeriasat-1, the second enhanced microsatellite of the DMC. Thirdly, arriving slightly earlier in August 2001, a team from Tubitak-Bilten in Turkey commenced their KHTT programme with BILSAT-1, a high-capability enhanced microsatellite also contributing to the DMC, and are due to continue through

  9. Place Attachment in a Sustainable Neighbourhood: Comparison of Two Cases in Surrey, B.C

    Directory of Open Access Journals (Sweden)

    Karim W.F. Youssef

    2015-10-01

    Full Text Available Scholars have voiced the emphasis of studies in sustainability on environmental sustainability over social sustainability. One of the dimensions of social sustainability is neighbourhood cohesion among residents of a neighbourhood. This paper compares the social sustainability of two neighbourhoods in Vancouver metropolitan area particularly in the city of Surrey, B.C. with respect to the sense of neighbourhood cohesion among their residents. Buckner’s (1988 instrument for measuring neighbourhood cohesion index is used with the addition of a few questions to probe for a new conception of space that may link the degree of accessibility and permeability of a neighbourhood (or degree of gated-ness with the level of neighbourhood cohesion. Results of qualitative and quantitative analysis show that the neighbourhood having an enclosure model had a higher level of neighbourhood cohesion than the neighbourhood with an encounter model on both the affective and interactive dimensions of neighbourhood cohesion.

  10. The University of Surrey database of elemental composition of human hair

    International Nuclear Information System (INIS)

    Altaf, W.J.; Akanle, O.A.; Admans, L.L.; Beasley, D.; Butler, C.; Spyrou, N.M.

    2004-01-01

    The elemental composition of human hair obtained from different studies at Surrey University over a period of 25 years has been recorded and forms part of a database, for biological and environmental samples, which is being developed. Instrumental neutron activation analysis (IAA), using reactor neutrons, was the principal method employed and from which reported data are presented. Elemental concentrations of Br, Ca, Ce, Cl, Co, Cr, Cs, F, Fe, Hf, K, Mg, Mn, Na, Rb, Sb, Sc, Se, V and Zn were obtained and recorded in the database. Chronological variations in two sets of subjects separated by a period of time of 16 years are also given. Variations in the concentration values of some elements related to the state of health and disease were reported for hair samples collected from subjects suffering from manic depression, senile dementia and breast cancer. Concentration values of some elements with relation to the nationality of subjects from Bulgaria, England, Kenya, Nigeria and Wales are presented and compared. This study is part of on-going research in the analysis of biomedical and bioenvironmental materials. The database is still in its infancy. (author)

  11. Effects of lunar phase on sleep in men and women in Surrey.

    Science.gov (United States)

    Della Monica, Ciro; Atzori, Giuseppe; Dijk, Derk-Jan

    2015-12-01

    Recently, evidence has emerged that the phases of the moon may modulate subjective sleep quality and polysomnographically assessed sleep structure in humans. We aimed to explore further the putative effects of circa-lunar periodicity (~29.5 days) on subjective and objective parameters of human sleep in a retrospective analysis. The baseline sleep recordings of 205 (91 males and 114 females; mean age = 47.47 years, standard deviation =19.01; range: 20-84 years) healthy and carefully screened participants who participated in two clinical trials in the Surrey Clinical Research Centre were included in the analyses. Sleep was recorded in windowless sleep laboratories. For each study night, we calculated the distance, in days, to the date of the closest full moon phase and based on this distance, classified sleep records in three lunar classes. Univariate analysis of variance with factors lunar class, age and sex was applied to each of 21 sleep parameters. No significant main effect for the factor lunar class was observed for any of the objective sleep parameters and subjective sleep quality but some significant interactions were observed. The interaction between lunar class and sex was significant for total sleep time, Stage 4 sleep and rapid eye movement (REM) sleep. Separate analyses for men and women indicated that in women total sleep time, Stage 4 sleep and REM sleep were reduced when sleep occurred close to full moon, whereas in men REM duration increased around full moon. These data provide limited evidence for an effect of lunar phase on human sleep. © 2015 European Sleep Research Society.

  12. An investigation into the move towards electronic journals: a case study of NHS libraries in Kent, Surrey and Sussex.

    Science.gov (United States)

    England, Rebecca

    2013-09-01

    Electronic journals are so embedded into practice in academic libraries that it is easy to forget that this is not the case everywhere. In NHS libraries, for example, the staff face a particular set of issues. This article is based on Rebecca England's dissertation on this topic, completed as part of the MSc Econ course in Information and Library studies at Aberystwyth University. Rebecca is E-resources Librarian at the Maidstone and Tunbridge Wells NHS Trust. She investigated the momentum towards electronic journals in NHS libraries in the Kent, Surrey and Sussex region and the potential for a regional purchasing consortium. © 2013 The author. Health Information and Libraries Journal © 2013 Health Libraries Group.

  13. A study to assess the quality of information in referral letters to the orthodontic department at Kingston Hospital, Surrey.

    Science.gov (United States)

    Izadi, Maryam; Gill, Daljit S; Naini, Farhad B

    2010-04-01

    To assess the quality of information included in referral letters sent to the orthodontic department at Kingston Hospital, Surrey, UK. Referral letters sent by both general dental practitioners (GDPs) and specialist orthodontists were analysed retrospectively in order to ascertain the percentage meeting the inclusion criteria as suggested by Mossey (2006) and the British Orthodontic Society (2008) for the quality of information included in an ideal orthodontic referral letter. Thirty-five consecutive letters sent between May and September 2005 and 206 letters sent in the same period in 2008 were collected by hand and analysed against the inclusion criteria. The numbers of referral letters received from GDPs, specialist orthodontists, and others sources were also determined. Most of the referrals sent in 2005 and 2008 included 40-50% of the referral inclusion points. This was despite an almost twofold increase in the number of referral letters received from specialist orthodontic practitioners in 2008. The majority of the letters, from both GDPs and specialists, did not include details of the oral hygiene or caries status of the patient, or an indication of their motivation towards treatment. None of the referral letters included a plaque score. The main weaknesses in the quality of information provided in referral letters were that in more than 80% of the letters there was no mention of the patient's medical history and no comment on caries status, the standard of oral hygiene, patient motivation for treatment, or an Index of Orthodontic Treatment Need score. The quality of information included in referral letters sent to Kingston Hospital orthodontic department needs to be improved.

  14. MeV single-ion beam irradiation of mammalian cells using the Surrey vertical nanobeam, compared with broad proton beam and X-ray irradiations

    Energy Technology Data Exchange (ETDEWEB)

    Prakrajang, K. [Plasma and Beam Physics Research Facility, Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200 (Thailand); Faculty of Science, Maejo University, Chiang Mai 50290 (Thailand); Jeynes, J.C.G.; Merchant, M.J.; Kirkby, K.; Kirkby, N. [Surrey Ion Beam Center, Faculty of Engineering and Physical Science, University of Surrey, Guildford Surrey, GU2 7XH (United Kingdom); Thopan, P. [Plasma and Beam Physics Research Facility, Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200 (Thailand); Yu, L.D., E-mail: yuld@fnrf.science.cmu.ac.th [Plasma and Beam Physics Research Facility, Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200 (Thailand); Thailand Center of Excellence in Physics, Commission on Higher Education, 328 Si Ayutthaya Road, Bangkok 10400 (Thailand)

    2013-07-15

    Highlights: •Recently completed nanobeam at the Surrey Ion Beam Centre was used. •3.8-MeV single and broad proton beams irradiated Chinese hamster cells. •Cell survival curves were measured and compared with 300-kV X-ray irradiation. •Single ion irradiation had a lower survival part at ultra-low dose. •It implies hypersensitivity, bystander effect and cell cycle phase of cell death. -- Abstract: As a part of a systematic study on mechanisms involved in physical cancer therapies, this work investigated response of mammalian cells to ultra-low-dose ion beam irradiation. The ion beam irradiation was performed using the recently completed nanobeam facility at the Surrey Ion Beam Centre. A scanning focused vertical ion nano-beam was applied to irradiate Chinese hamster V79 cells. The V79 cells were irradiated in two different beam modes, namely, focused single ion beam and defocused scanning broad ion beam of 3.8-MeV protons. The single ion beam was capable of irradiating a single cell with a precisely controlled number of the ions to extremely low doses. After irradiation and cell incubation, the number of surviving colonies as a function of the number of the irradiating ions was measured for the cell survival fraction curve. A lower survival for the single ion beam irradiation than that of the broad beam case implied the hypersensitivity and bystander effect. The ion-beam-induced cell survival curves were compared with that from 300-kV X-ray irradiation. Theoretical studies indicated that the cell death in single ion irradiation mainly occurred in the cell cycle phases of cell division and intervals between the cell division and the DNA replication. The success in the experiment demonstrated the Surrey vertical nanobeam successfully completed.

  15. Archives of the Dance (22): Pioneer Women – early British modern dancers (the National Resource Centre for Dance, University of Surrey).

    OpenAIRE

    Carter, Alexandra

    2010-01-01

    Pioneer Women was an AHRC-funded project based on archives held at the National Resource Centre for Dance, University of Surrey. Two of the largest collections, those on Madge Atkinson and Natural Movement, and Ruby Ginner’s Revived (later Classical) Greek Dance, are categorized and interrogated for not only what they reveal of the work of these two dance artists, but also for how they resonate with dominant cultural trends in the arts. The research privileges a much under-explored or theoriz...

  16. Reducing travel by design: a micro analysis of new household location and the commute to work in Surrey

    Science.gov (United States)

    Hickman, Robin

    , house value, respondent sex, respondent age, marital status, occupation, qualification, attitude to travel, attitude to home and home location, reason for moving home and choosing new home location, relative levels of mobility, and dual income households. The methodological approach is to systematically examine the study hypothesis and a series of related research questions using data from the county of Surrey, UK. The empirical analysis is based on two new household occupier surveys carried out in 1998 and 2001, together with additional, complementary data taken from local authority datasets and the Census 2001. The thesis's particular originality is in providing: An examination of the complexity of the land use and transport interaction field, using energy consumption as the dependent variable and an estimation of the strength and significance of a wide range of land use and socio-economic variables - both previously researched and under researched variables A segmentation of respondents into different groups, such as stayers, inmovers and outmovers, showing the different manifestation of the land use and transport relationship for different groups within society A systematic tracking of the impact of time on the land use and transport relationship, with temporality and adaptation (including "co-location" effects) noted as critical features in travel behaviour, with the analysis controlling for potential attrition factors Analysis of a seldom-studied London fringe/suburban county such as Surrey - much previous work is concentrated on the city or other urban areas. The key findings and recommendations are that each land use, socio-economic and attitudinal variable, when considered on its own or even in small groupings, offers limited explanatory power in explaining travel behaviour. When a number of variables are brought together, including some variables not usually considered in the literature, the explanatory power of the modelling begins to work. Linear regression

  17. 15 January 2010 - Vice-Chancellor & Chief Executive C. Snowden, University of Surrey, United Kingdom and Mrs Snowden visiting ALICE exhibition and experimental undeground area with Collabortion Spokesperson J. Schukraft and Beams Department Head P. Collier; Signature of the guest book with CERN Director-General R. Heuer.

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    15 January 2010 - Vice-Chancellor & Chief Executive C. Snowden, University of Surrey, United Kingdom and Mrs Snowden visiting ALICE exhibition and experimental undeground area with Collabortion Spokesperson J. Schukraft and Beams Department Head P. Collier; Signature of the guest book with CERN Director-General R. Heuer.

  18. Bιβλιοκρισία του: P. ANTONOPOULOS, The Reign of Cunincpert. Saga, Reality, Stability and Progress in Lombard Italy at the End of the Seventh Century, Porphyrogenitus Ltd, Camberley, Surrey 2010

    Directory of Open Access Journals (Sweden)

    Κωνσταντίνος ΧΡΗΣΤΟΥ

    2012-03-01

    Full Text Available ΒΙβλιοκρισία του: P. ANTONOPOULOS, The Reign of Cunincpert. Saga, Reality, Stability and Progress in Lombard Italy at the End of the Seventh Century, Porphyrogenitus Ltd, Camberley, Surrey 2010, σσ. Χ+138 (ΙSBN 1 871328 18 7.

  19. Time Mirrored: Reflecting Around the Surrey Canal

    OpenAIRE

    Lanuza, Felipe

    2014-01-01

    Burgess Park (Camberwell, South London) still retains some clues of its layered formation and the previous existence of the site as a bustling industrial quarter. Nonetheless, most of its open green spaces and recently renovated facilities stand in the absence of old houses and factories. On the morning of Friday 13 October 2013 I went to that park and photographed one of these cleared parts with a digital camera.

  20. Surrey, British Columbia: Book Ban in the Courts

    Science.gov (United States)

    Carter, Julie H.

    2004-01-01

    In light of its recent and unequivocal support of gay civil unions, Canada enhanced its reputation as the most tolerant and progressive country in the western hemisphere. Regardless of how far people come in the fight for lesbian, gay, bisexual and transgender visibility, there will be minor setbacks along the way. Around the same time as the…

  1. Bartuccelli, M. V.; Woolcock, C. J. (University of Surrey, Dept. of Mathematics, Guildford (GB))

    Energy Technology Data Exchange (ETDEWEB)

    On the positivity of solutions for a generalized diffusion model

    2001-12-01

    The objective of this paper aims to prove positivity of solutions for the following semilinear dissipative partial differential equation: u{sub t} -{alpha}{upsilon}{sub x}xxx - {upsilon}{sub x}x - {upsilon}{upsilon}{sub x} + {upsilon}(1-{upsilon}{sup 2}). The equation can be considered as a model equation representing a class of dissipative partial differential equations containing differential operators of higher order than the Laplacian. It appears in various scientific contexts including population dynamics and chemical reactions, where the solutions of the model must be positive functions.

  2. An Alternative Energy Career Project at the Warwick School, Redhill, Surrey

    Science.gov (United States)

    Balmer, Denise

    2014-01-01

    The article describes an innovative project for year 9 (age 13-14) students that has run since 2002 with the help of professional engineers and scientists and incorporates careers information and hands-on practical work. The programme was developed to highlight alternative energy as a subject and also to provide a hands-on practical day for the…

  3. Mansion Nolan en Worcester Park - Surrey - Gran Bretaña

    Directory of Open Access Journals (Sweden)

    Stout & Litchfield, Arquitectos

    1973-04-01

    Full Text Available The site is the end plot in a cul-de-sac of new houses, in the immediate neighbourhood of an old convent. The house is designed as two identical flats: — on the ground floor the entrance hall, the children's bedrooms, bathroom, dining room and kitchen, — on the first floor the parents bedroom with bathroom suite and living room, both open onto a roof terrace. The walls are constructed of while sandlime bricks with white pointing, cavity and light-weight concrete insulating blocks internally. The roofs are externally clad with natural slate and internally with Columbian Pine boarding. The slope of the roof is exposed internally. Walls are white painted throughout and the floors are covered with grey haircord carpet. The staircase is made of Columbian Pine and is open tread. Heating is by gas fired ducted warm air.Esta vivienda se ha construido en la parcela final de un fondo de saco, situado en las proximidades de un antiguo convento. El edificio consta de dos plantas: - en la baja se han dispuesto, además de la entrada, los dormitorios de los niños, un cuarto de baño, el comedor y la cocina, y - en la primera, el dormitorio de los padres, con cuarto de baño y una sala de estar, abiertos ambos sobre amplias terrazas. Sistema constructivo: muros exteriores construidos con ladrillo blanco, rejuntados con mortero blanco; los muros interiores y huecos se realizaron con placas o bloques de hormigón ligero aislado, pintados de blanco posteriormente. En el interior se respetó la inclinación de la cubierta, revistiéndola con un entablado de pino colombiano; en el exterior se utilizó un recubrimiento de pizarra natural. Los suelos están enmoquetados, con alfombras de pelo, de color gris. La calefacción se consigue por conducciones de aire caliente, producido por estufa de gas.

  4. Conference of University Administrators Conference Proceedings (12th, Surrey, England, March 21-23, 1985).

    Science.gov (United States)

    Conference of Univ. Administrators.

    Conference proceedings for the Conference of University Administrators include summaries of conference sessions, along with Austin Pearce's paper, "The Needs of Industry: What Are They?" Sessions focused on: forming a university company, financial diversification, financial modeling, stock exchange investment and universities, funding of…

  5. International Symposium on Solubility Phenomena (3rd) Held in Guildford, Surrey England on 23 - 26 August 1988

    Science.gov (United States)

    1988-08-26

    solubilities is, first of all, important for metallurgy, electrochemistry, nuclear and space technology. Experimental solubilities of metals in liquid Hg...Dianderas de Acosta and I.FernAndez Paz Departamento de Quimica Universidad Nacional de San Agustin, Arequipa, Peru Equilibria and derived free

  6. Computers, gezondheid, ergonomie en arbeid : verslag van een discussiebijeenkomst, 18 en 19 oktober, University of Surrey (UK)

    NARCIS (Netherlands)

    Thé, K.; Looze, M.P. de

    2000-01-01

    Een groep Europese onderzoekers kwam half oktober bij elkaar in Guildford (Engeland) op uitnodiging van Peter Buckle. Deze naam al velen bekend in de oren klinken, want hij is onderzoeker van wereldformaat op het gebied 'arbeidsgebonden klachten aan het bewegingsapparaat'. De bijeenkomst werd

  7. Ion Implantation Technology: Proceedings of the International Conference on Ion Implantation Technology (8th) Held at the University of Surrey, Guildford, UK on 30 July - 3 August 1990

    Science.gov (United States)

    1991-01-01

    1988, 13] P. Dierckx, Computing 24 (1980) 349. Vacuum (1990) in press. [4] D.A.G Bruggeman. Annalen der Physik 5 ( 1935 ) 636. T4 Ill. THROUGHPUT...1986) 229try to determine damage depth profiles in ion-im- 11SAG rggan.nnPy2493)6 [121 S.A G Bruggemann, Ann Phys 24 ( 1935 ) 636 planted...34indefinite" point substrate semiconductors [3-7]. defects should reflect the distribution of lightly damaged We have previously reported the results of EPR

  8. Current Scientific Approaches to Decision Making in Complex Systems: 3. Volume 1. Conference Proceedings. Third Conference, Richmond, Surrey, England, 6-8 August 1978

    Science.gov (United States)

    1980-01-01

    good decisions. What usually prevents him from implementing those rational decisions is either an overstrong conflict, leading to behavioural paralysis...of Prosocial Behaviour in the group situation. It assumes a typology of people, and attempts to show sequentially how people are influenced in their...COVERED CURRENT SCIENTIFIC APPROACHES TO DECISION MAKING IN COMPLEX SYSTEMS: III. Volume I, Conference Proceedings 6. PERFORMING ORG. REPORT NUMBER 7

  9. Symposium on ‘Geographical and geological influences on nutrition’ Iodine deficiency in industrialised countries: Conference on ‘Over- and undernutrition: challenges and approaches’ on 30 June–2 July 2009, The Summer Meeting of the Nutrition Society, was held at the University of Surrey, Guildford

    NARCIS (Netherlands)

    Zimmermann, M.B.

    2010-01-01

    Iodine deficiency is not only a problem in developing regions; it also affects many industrialised countries. Globally, two billion individuals have an insufficient iodine intake, and approximately 50% of continental Europe remains mildly iodine deficient. Iodine intakes in other industrialised

  10. Evaluation and Effectiveness of Pain Recognition and Management Training for Staff Working in Learning Disability Services

    Science.gov (United States)

    Mackey, Ellen; Dodd, Karen

    2011-01-01

    Following Beacroft & Dodd's (2009) audit of pain recognition and management within learning disability services in Surrey, it was recommended that learning disability services should receive training in pain recognition and management. Two hundred and seventy-five services were invited to participate, of which 197 services in Surrey accepted…

  11. The importance of research in healthcare

    African Journals Online (AJOL)

    Research and Development Department. Chertsey, Surrey KT13 0SY. UK. Correspondence: ... 5 days and were passed fit to return to work on the ship. It was the ... clinical management and creates a culture of continual learning and ...

  12. Kosmosesatelliidid taskukohaseks / Mart Vihmand

    Index Scriptorium Estoniae

    Vihmand, Mart

    2008-01-01

    Viis Eesti teadlast ja spetsialisti külastas Londoni lähistel Guilfordi linnakeses asuvat maailma üht juhtivat erakapitalil põhinevat kosmosesatelliitide tootjat Surrey Satellite Technology Limited

  13. Peer-Allocated Instant Response (PAIR): Computional allocation of peer tutors in learning communities

    NARCIS (Netherlands)

    Westera, Wim

    2009-01-01

    Westera, W. (2007). Peer-Allocated Instant Response (PAIR): Computational allocation of peer tutors in learning communities. Journal of Artificial Societies and Social Simulation, http://jasss.soc.surrey.ac.uk/10/2/5.html

  14. Syntheses of amine-type adsorbents with emulsion graft polymerization of glycidyl methacrylate

    International Nuclear Information System (INIS)

    Seko, N.; Bang, L.T.; Tamada, M.

    2007-01-01

    Glycidyl methacrylate (GMA) which was precursor monomer for the synthesis of metal ion adsorbent was emulsified by surfactant of Tween 20 (Tw-20). The emulsion of 5% GMA in the water was stable for 48 h at Tw-20 concentration of 0.5%. Graft polymerization of GMA on polyethylene fiber was carried out in the emulsion state at various pre-irradiation doses. Degree of grafting (Dg) reached 103%, 301% and 348% for 1 h grafting at 40 deg. C with pre-irradiation of 10, 30 and 40 kGy, respectively. But the Dg was depressed when the pre-irradiation dose was over 50 kGy since cross-linking occurred simultaneously in the trunk polymer. Dg decreased with increment of Tw-20 concentration in emulsion of 5% GMA at pre-irradiation of 40 kGy. The three kinds of amine-type adsorbents were synthesized by reacting diethylenetriamine (DETA), triethylenetetramine (TETA) and ethylenediamine (EDA) with GMA-grafted polyethylene fiber. The synthesized EDA-type adsorbent had the highest selectivity against U ion and the distribution coefficient was 2.0 x 10 6

  15. An experimental and theoretical kinetic study of the reaction of OH radicals with tetrahydrofuran

    KAUST Repository

    Giri, Binod

    2016-06-24

    Tetrahydrofuran (CHO, THF) and its alkylated derivatives of the cyclic ether family are considered to be promising future biofuels. They appear as important intermediates during the low-temperature oxidation of conventional hydrocarbon fuels and of heavy biofuels such as long-chain fatty acid methyl esters. The reaction of tetrahydrofuran with OH radicals was investigated in a shock tube, over a temperature range of 800-1340 K and at pressures near 1.5 bar. Hydroxyl radicals were generated by the rapid thermal decomposition of tert-butyl hydroperoxide, and a UV laser absorption technique was used to monitor the mole fraction of OH radicals. High-level CCSD(T)/cc-pV(D,T)Z//MP2/aug-cc-pVDZ quantum chemical calculations were performed to explore the chemistry of the THF+OH reaction system. Our calculations reveal that the THF+OH (R1) reaction proceeds via either direct or indirect H-abstraction from various sites, leading to the formation of tetrahydrofuran-2-yl (THF-R2) or tetrahydrofuran-3-yl (THF-R3) radicals and water. Theoretical kinetic analysis revealed that both channels are important under conditions relevant to combustion. To our knowledge, this is the first direct experimental and theoretical kinetic study of the reaction of tetrahydrofuran with OH radicals at high temperatures. The following theoretical rate expressions (in units of cmmols) are recommended for combustion modeling in the temperature range 800-1350 K: . k1(T)=4.11×1040.16em0ex(TK)2.69exp(1316.80.16em0exKT)2.em0ex0.16em0ex(THF+OH→Products) . k2(T)=6.930.16em0ex×10110.16em0ex(TK)0.41exp(-106.80.16em0exKT)2.em0ex0.16em0ex(THF+OH→THF-R20.16em0ex+H2O) . k3(T)=4.120.16em0ex×1030.16em0ex(TK)3.02exp(456.90.16em0exKT)2.em0ex0.16em0ex(THF+OH→THF-R30.16em0ex+H2O) . .

  16. Elemental analysis of hair using PIXE-tomography and INAA

    International Nuclear Information System (INIS)

    Beasley, D.; Gomez-Morilla, I.; Spyrou, N.

    2008-01-01

    3D quantitative elemental maps of a section of a strand of hair were produced using a combination of PIXE-Tomography and simultaneous On/Off Axis STIM-Tomography at the University of Surrey Ion Beam Centre. The distributions of S, K, Cl, Ca, Fe and Zn were determined using the PIXE-T reconstruction package DISRA. The results were compared with conventional bulk PIXE analysis of tomographic data as determined using Dan32. The overall concentrations determined by PIXE were compared with elemental concentrations held in the University of Surrey Hair Database. All the entries currently in the database were produced using INAA. The merits and possible contributions of tomographic PIXE analysis to analysis of hair are discussed. The conclusions drawn from the PIXE-Tomography analysis can be used to argue for more stringent procedures for hair analysis at the University of Surrey. (author)

  17. Undergraduate courses with an integral research year

    International Nuclear Information System (INIS)

    Clough, A S; Regan, P H

    2003-01-01

    We present the details of the four year MPhys undergraduate degree provided by the University of Surrey. Integral to this course is a full year spent on a research placement, which in most cases takes place external to the university at a North American or European research centre. This paper outlines the basic rationale underlying the course and, by including a number of research student profiles, we discuss the triple benefits of this course for the students, the University of Surrey and the host institutions where the students spend their research year

  18. State of progress in Malaysian plant Taxonomy

    NARCIS (Netherlands)

    NN,

    1948-01-01

    Dr H.C.D. de Wit started a revision of Malaysian Bauhinia, this being part of his work on the Caesalpiniaceae of Malaysia; he is working in the Eijksherbarium, Leyden, Holland. Mr R.A. Blakelock, is revising the genus Evonymus at the Roy. Bot. Gardens, Kew-Surrey.

  19. Immunogenic Response of Rabbits to Monovalent and Polyvalent ...

    African Journals Online (AJOL)

    This work was carried out in University of Surrey UK Department of Microbiology. In this study, the efficacy of monovalent and polyvalent vaccines made from Mannhaemia haemolytica antigens, were evaluated by measuring specific serum antibody titers produced against the bacteria in immunized rabbits. Eleven biotype A ...

  20. Richard J. Hill, Picturing Scotland through the Waverley Novels: Walter Scott and the Origins of the Victorian Illustrated Novel.

    Directory of Open Access Journals (Sweden)

    Jacqueline Irene Cannata

    2012-10-01

    Full Text Available Richard J. Hill, Picturing Scotland through the Waverley Novels: Walter Scott and the Origins of the Victorian Illustrated Novel . Farnham, Surrey, and Burlington, VT: Ashgate, 2010. Pp. 236. ISBN 978-0-7546-6806-0. US$99.99.

  1. Let's say goodbye : The moralising practices of gap year organisations in the Netherlands

    NARCIS (Netherlands)

    Hermann, I. (Inge)

    2013-01-01

    http://cts.som.surrey.ac.uk/publication/lets-say-goodbye-the-moralising-practices-of-gap-year-organisations-in-the-netherlands/wppa_open/   Responding to the growing appeal of the gap year amongst young people, the higher education sector, governmental institutions and, perhaps foremost, the

  2. CORRIGENDUM

    African Journals Online (AJOL)

    Are social media applications a facilitator or barrier to learning for tourism and hospitality management students? Research in Hospitality Management, 6(2), 195–202. https://doi.org/10.1080/22243534.2016.1253289. Acknowledgement — I thank University of Surrey, University of Derby, and Bath Spa University for allowing ...

  3. Workshop report: Proceedings of the Rank Forum on Vitamin D

    NARCIS (Netherlands)

    Lanham-New, S.A.; Buttriss, J.L.; Miles, L.M.; Ashwell, M.; Berry, J.L.; Boucher, B.J.; Cashman, K.D.; Cooper, C.; Darling, A.L.; Francis, R.M.; Fraser, W.D.; Groot, de C.P.G.M.; Hypponen, E.; Kiely, M.; Lamberg-Allardt, C.; Macdonald, H.M.; Martineau, A.R.; Masud, T.; Mavroeidi, A.; Nowson, C.; Prentice, A.; Stone, E.M.; Reddy, S.; Vieth, R.; Williams, M.

    2011-01-01

    The Rank Forum on Vitamin D was held on 2nd and 3rd July 2009 at the University of Surrey, Guildford, UK. The workshop consisted of a series of scene-setting presentations to address the current issues and challenges concerning vitamin D and health, and included an open discussion focusing on the

  4. Observations on the reliability of COTS-device-based solid state data recorders operating in low-earth orbit

    International Nuclear Information System (INIS)

    Underwood, C.I.

    1999-01-01

    This paper presents the results of Surrey Space Centre's experience in using different coding schemes and hardware configurations to protect data and protect data and software stored in COTS-device (Commercial-Off-The-Shelf) based memories on-board operational spacecraft in low Earth orbit. (author)

  5. HCA leading the way to change.

    Science.gov (United States)

    2014-06-03

    A hospital ward run by healthcare assistants? Some might be sceptical, but not patients at Headley Court Defence Medical Rehabilitation Centre in Surrey who are about to be discharged from the military into civvy street. For them, the HCA-led ward is a welcome change from the traditional medically intense nurse-led units.

  6. Gender Associations for Musical Instruments in Nursery Children: The Effect of Sound and Image

    Science.gov (United States)

    Marshall, Nigel; Shibazaki, Kagari

    2013-01-01

    This paper reports on the results of a study carried out with 105 children, aged between three and four years in three nursery units in London and Surrey, UK. The aim of this study was to explore the level of association which young children have between various musical instruments, musical styles and a particular gender. However, we also aimed to…

  7. A Comparison of Keyword Subject Searching on Six British University OPACs Online Public Access Catalogs.

    Science.gov (United States)

    Aanonson, John

    1987-01-01

    Compares features of online public access catalogs (OPACs) at six British universities: (1) Cambridge; (2) Hull; (3) Newcastle; (4) Surrey; (5) Sussex; and (6) York. Results of keyword subject searches on two topics performed on each of the OPACs are reported and compared. Six references are listed. (MES)

  8. A Fossil-Based Enquiry Day Stimulates Children to Think Scientifically

    Science.gov (United States)

    Balmer, Denise

    2015-01-01

    SATRO (Science And Technology Regional Organisation), a charity based in Surrey that seeks to inspire young people about their future careers, received a call from a local junior school just before Easter last year from a science coordinator who was in tears. Her school had just been made a "failing school" and science was a disaster; no…

  9. Instrumentality, Expressivity, and Relational Qualities in the Same-Sex Friendships of College Women and Men

    Science.gov (United States)

    Frey, Lisa L.; Beesley, Denise; Hurst, Rebecca; Saldana, Star; Licuanan, Brian

    2016-01-01

    Using the relational-cultural model (Jordan, Kaplan, Miller, Stiver, & Surrey, 1991), the authors hypothesized that instrumentality, expressivity, and the individual affective experience of same-sex friendships would predict increased relationship mutuality, with college women and men showing different predictive patterns. Overall, results…

  10. Computer Aided Teaching of Digital Signal Processing.

    Science.gov (United States)

    Castro, Ian P.

    1990-01-01

    Describes a microcomputer-based software package developed at the University of Surrey for teaching digital signal processing to undergraduate science and engineering students. Menu-driven software capabilities are explained, including demonstration of qualitative concepts and experimentation with quantitative data, and examples are given of…

  11. Physician-led committee tackles youth-violence problem in one of Canada's fastest-growing cities.

    OpenAIRE

    O'Brien-Bell, J

    1995-01-01

    Dr. John O'Brien-Bell, a past president of the CMA, recently chaired the Advisory Committee on Youth Violence in Surrey, BC. It studied issues such as the incidence of violence, the evolution taking place in the city and society, and the erosion of traditional social values. In its final report, the committee recommended 78 possible steps for reducing violence among young Canadians.

  12. Antecedents and Consequences of Toxic Leadership in the U. S. Army: A Two Year Review and Recommended Solutions

    Science.gov (United States)

    2011-06-30

    command climate from his superior officer or Bourke ‟s (2005) description of UK executive officers‟ attempts to dismiss Soldier brutalization, prisoner...in the Anglo-West. Australian Defence Force Journal, 169, 4-14. Bourke , J. (2005, February 26). From Surrey to Basra, abuse is a fact of British

  13. Perceived causes of differential attainment in UK postgraduate medical training: a national qualitative study

    OpenAIRE

    Woolf, K. V. M.; Rich, A.; Viney, R.; Needleman, S.; Griffin, A.

    2016-01-01

    Objectives: Explore trainee doctors’ experiences of postgraduate training and perceptions of fairness in relation to ethnicity and country of primary medical qualification. Design: Qualitative semistructured focus group and interview study. Setting: Postgraduate training in England (London, Yorkshire and Humber, Kent Surrey and Sussex) and Wales. Participants: 137 participants (96 trainees, 41 trainers) were purposively sampled from a framework comprising: doctors ...

  14. Smoking in Pregnancy and Parenthood: What Is the Role of Depression, Anxiety and Nicotine Addiction?

    Science.gov (United States)

    Bull, Leona; Burke, Ronan; Walsh, Siobhan; Whitehead, Emma

    2003-01-01

    Examined attitudes toward smoking, current smoking behavior, mental health difficulties, and nicotine addiction among 38 pregnant women, mothers of young children, and their partners in East Surrey, England. Found that 11 female respondents presented symptoms of depression, anxiety, or social dysfunction. Smokers did not differ from ex-smokers or…

  15. The Clubbers' Guide: A Treasure Trove of Science Activities/A Treasure Hunt through Time and Space

    Science.gov (United States)

    Howarth, Sue; Scott, Linda; Carter, Liz

    2013-01-01

    This issue of Clubbers' Guide contains an article written by Liz Carter, Senior Science Technician at the Warwick School, Redhill, Surrey (UK), describing some of the wide variety of science, technology, engineering and mathematics (STEM) based activities that her school puts on during an eight-day summer school in the holidays for prospective…

  16. Corrigendum | Gehrels | Research in Hospitality Management

    African Journals Online (AJOL)

    Li, L. (2016). Are social media applications a facilitator or barrier to learning for tourism and hospitality management students? Research in Hospitality Management, 6 (2), 195–202. https://doi.org/10.1080/22243534.2016.1253289. Acknowledgement — I thank University of Surrey, University of Derby, and Bath Spa ...

  17. "I Feel Pain"--Audit of Communication Skills and Understanding of Pain and Health Needs with People with Learning Disabilities

    Science.gov (United States)

    Beacroft, Monica; Dodd, Karen

    2011-01-01

    An audit was conducted across Surrey to investigate pain recognition and management with people with learning disabilities. This section of the audit looked at what people with learning disabilities understood and experienced when they had pain compared to good practice from the literature. The results show that people with learning disabilities…

  18. Effects of frequently used pharmaceutical excipients on the organic cation transporters 1-3 and peptide transporters 1/2 stably expressed in MDCKII cells.

    Science.gov (United States)

    Otter, Marcus; Oswald, Stefan; Siegmund, Werner; Keiser, Markus

    2017-03-01

    There is ample evidence that pharmaceutical excipients, which are supposed to be pharmacologically inactive, have an impact on drug metabolism and efflux transport. So far, little is known whether they also modulate uptake transporter proteins. We have recently shown that commonly used solubilizing agents exert significant effects on the function of organic anion uptake transporting polypeptides. Therefore, we investigated in this study the influence of frequently used pharmaceutical excipients on the transport activity of organic cation transporters OCT1, OCT2 and OCT3 and the peptide transporters PEPT1 and PEPT2. Inhibition of the OCTs and PEPTs by the excipients polyethylene glycol 400 (PEG), hydroxypropyl-β-cyclodextrin (HPCD), Solutol® HS15 (SOL), Cremophor® EL (CrEL), Tween® 20 (Tw20), Tween® 80 (Tw80), Kolliphor® P188 (P188) and Kolliphor® P407 (P407) was evaluated using stably transfected MDCKII cells with radio-labeled reference substrates and established inhibitors as controls. Intracellular accumulation of [3H]-1-methyl-4-phenylpyridinium (MPP + ) for the OCTs and [3H]-glycyl-sarcosine (Gly-Sar) for the PEPTs was measured by liquid scintillation counting after cell lysis. Our studies revealed that PEG, HPCD, SOL, CrEL, Tw20 and Tw80 were potent inhibitors of OCT1-3 (e.g., Tw20 IC 50 values<0.04%). Cellular uptake of Gly-Sar by PEPT1 and PEPT2 was strongly inhibited by both Tw20 and Tw80. SOL was also a strong inhibitor of PEPT1 and PEPT2 (e.g., SOL IC 50 values<0.02%), while CrEL showed significantly inhibition of only PEPT2. The substantial inhibitory effects of certain solubilizing agents on OCTs and PEPTs should be considered if they are to be used in dosage forms for new chemical entities and registered drugs to avoid misinterpretation of pharmacokinetic data and undesired drug interactions. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Modelling UK energy demand to 2000

    International Nuclear Information System (INIS)

    Thomas, S.D.

    1980-01-01

    A recent long-term demand forecast for the UK was made by Cheshire and Surrey. (SPRU Occasional Paper Series No.5, Science Policy Research Unit, Univ. Of Sussex, 1978.) Although they adopted a sectoral approach their study leaves some questions unanswered. Do they succeed in their aim of making all their assumptions fully explicit. How sensitive are their estimates to changes in assumptions and policies. Are important problems and 'turning points' fully identified in the period up to and immediately beyond their time horizon of 2000. The author addresses these questions by using a computer model based on the study by Cheshire and Surrey. This article is a shortened version of the report, S.D. Thomas, 'Modelling UK Energy Demand to 2000', Operational Research, Univ. of Sussex, Brighton, UK, 1979, in which full details of the author's model are given. Copies are available from the author. (author)

  20. Modelling UK energy demand to 2000

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, S D [Sussex Univ., Brighton (UK)

    1980-03-01

    A recent long-term demand forecast for the UK was made by Cheshire and Surrey. (SPRU Occasional Paper Series No.5, Science Policy Research Unit, Univ. Of Sussex, 1978.) Although they adopted a sectoral approach their study leaves some questions unanswered. Do they succeed in their aim of making all their assumptions fully explicit. How sensitive are their estimates to changes in assumptions and policies. Are important problems and 'turning points' fully identified in the period up to and immediately beyond their time horizon of 2000. The author addresses these questions by using a computer model based on the study by Cheshire and Surrey. This article is a shortened version of the report, S.D. Thomas, 'Modelling UK Energy Demand to 2000', Operational Research, Univ. of Sussex, Brighton, UK, 1979, in which full details of the author's model are given. Copies are available from the author.

  1. Comparing formal verification approaches of interlocking systems

    DEFF Research Database (Denmark)

    Haxthausen, Anne Elisabeth; Nguyen, Hoang Nga; Roggenbach, Markus

    2016-01-01

    these approaches. As a first step towards this, in this paper we suggest a way to compare different formal approaches for verifying designs of route-based interlocking systems and we demonstrate it on modelling and verification approaches developed within the research groups at DTU/Bremen and at Surrey......The verification of railway interlocking systems is a challenging task, and therefore several research groups have suggested to improve this task by using formal methods, but they use different modelling and verification approaches. To advance this research, there is a need to compare....../Swansea. The focus is on designs that are specified by so-called control tables. The paper can serve as a starting point for further comparative studies. The DTU/Bremen research has been funded by the RobustRailS project granted by Innovation Fund Denmark. The Surrey/Swansea research has been funded by the Safe...

  2. Phase contrast X-ray imaging at the bone-cartilage interface

    International Nuclear Information System (INIS)

    Che Ismail, E.; Gundogdu, O.; Bradley, D.A.

    2008-01-01

    Full text: Phase contrast X-ray imaging is a simple technique to investigate various biological samples. At Surrey, the bone-cartilage interface is one of the biological samples which actively been studied. Bone-cartilage interface study gives a particular interest in this research as the degeneration of cartilage is the hallmark of the degenerative joint disease such as osteoarthritis. We have been applying the phase contrast imaging technique in studying the bone-cartilage interface, obtaining information on anatomical features such as the cartilage, blood vessel, tide mark and cement line. Our samples range from dry bone-cartilage to wet bone-cartilage tissue. This work will briefly review the basic supporting physics of the study. It also shows some of the images and other results that we have obtained to-date. Fig. 1 shows examples obtained using the X-ray tube system at the University of Surrey

  3. Canwest propane: Canwest Propane's newest terminal delivers the winning conditions for B.C. market expansion

    International Nuclear Information System (INIS)

    Anon

    2004-01-01

    Opening of a new propane terminal in Surrey, BC by Canwest Propane Ltd., is reported. The facility is the first rail terminal opened by Canwest, and is intended to serve the greater Vancouver area, Vancouver island and the US Northwest, specifically Washington State. The Surrey location allows the company to service its business by rail, the most efficient method of getting product to the Lower Mainland. The facility sits on 4.5 acres of land; a CN rail track runs alongside the site, where six 30,000 gallon storage tanks are located. About 60 million litres of propane is expected to be distributed from the terminal, with further expansion anticipated both on Vancouver Island and in the US Northwest. photos

  4. The Fine Art of Voting

    OpenAIRE

    Louise Clarke

    2015-01-01

    A three page interview with Bob and Roberta Smith including images of his artwork Bewildered by former Minister of State for Schools Michael Gove's inexorable undermining of art education, not to mention his successor MP Nicky Morgans's jaw-dropping pronouncement about 'the arts holding kids back', Patrick Brill, better known as artist Bob and Roberta Smith, has decided to stand for parliament as an independent in Gove's Surrey Heath seat, on an 'all schools should be art schools' ticket. ...

  5. Deviant Globalization and the Unintended Consequences of Coca Eradication in Colombia

    Science.gov (United States)

    2012-06-01

    Colombian Constitutional Court assumed a central role and had a significant impact on government policy and its response to the needs and...be said that the evidence today suggests that newly constituted forces are slowly emerging whereby legitimate state actors are increasing their...Solutions to Trans-Border Problems?: The Governance of Security and Risk in a post- NAFTA North America (Surrey, England: Ashgate Publishing, 2011), 149

  6. Jane Austen (1775-1817) and the cultural history of health.

    Science.gov (United States)

    Biddiss, Michael

    2014-08-01

    This paper provides a review of some aspects of the life and novels of Jane Austen that have particular bearing on her approach to issues of sickness and health. It is based on a Keynote Lecture given at the Annual Congress of the British Society for the History of Medicine on 1 September 2011 at the University of Surrey. © IMechE 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  7. “You can’t be a person and a doctor”. The work-life balance of doctors in training: a qualitative study

    OpenAIRE

    Rich, A.; Viney, R.; Needleman, S.; Griffin, A.; Woolf, K. V. M.

    2016-01-01

    Objectives Investigate the work–life balance of doctors in training in the UK from the perspectives of trainers and trainees. Design Qualitative semistructured focus groups and interviews with trainees and trainers. Setting Postgraduate medical training in London, Yorkshire and Humber, Kent, Surrey and Sussex, and Wales during the junior doctor contract dispute at the end of 2015. Part of a larger General Medical Council study about the fairness of postgraduate medical training. Part...

  8. ?You can't be a person and a doctor?: the work?life balance of doctors in training?a qualitative study

    OpenAIRE

    Rich, Antonia; Viney, Rowena; Needleman, Sarah; Griffin, Ann; Woolf, Katherine

    2016-01-01

    Objectives Investigate the work?life balance of doctors in training in the UK from the perspectives of trainers and trainees. Design Qualitative semistructured focus groups and interviews with trainees and trainers. Setting Postgraduate medical training in London, Yorkshire and Humber, Kent, Surrey and Sussex, and Wales during the junior doctor contract dispute at the end of 2015. Part of a larger General Medical Council study about the fairness of postgraduate medical training. Participants ...

  9. Book Reviews

    OpenAIRE

    Redactie KITLV

    2002-01-01

    -Greg Bankoff, Alfred W. McCoy, Lives at the margin; Biography of Filipinos obscure, ordinary and heroic. Madison, Wisconsin: Center for Southeast Asian Studies, University of Wisconsin-Madion, v + 481 pp. -Greg Bankoff, Clive J. Christie, Ideology and revolution in Southeast Asia 1900-1980; Political ideas of the anti-colonial era. Richmond, Surrey: Curzon Press, xi + 236 pp. -René van den Berg, Videa P. de Guzman ,Grammatical analysis; Morphology, syntax, and semantics; Studies in honor of ...

  10. 'Courage of conviction with compassion'.

    Science.gov (United States)

    Haidrani, Layla

    2017-08-30

    What is your job? I am chief executive officer (CEO) of Woking and Sam Beare Hospices, Surrey. The charity delivers specialist palliative care services to more than 1,400 patients and their families across six boroughs, and has recently moved into a brand new state-of-the-art hospice. My role includes the financial and business running of the hospice, along with fundraising, retail, governance and clinical services.

  11. Aerial Refueling For NATO’s Smart Defence Initiative

    Science.gov (United States)

    2012-04-01

    Rome: NATO Defense College, 2012, 148. 40 David A. Brown , "NATO Studying Development of Dedicated Refueling Unit Similar to Early Warning Force...accessed March 1, 2012). Brown , David A. "NATO Studying Development of Dedicated Refueling Unit Similar to Early Warning Force." Aviation Week...Aircraft. Coulsdon, Surrey: IHS Global Limited, 2011. Jennings, Gareth . "Nations Pool for NATO C-17A Fleet." Jane’s Defence Weekly, October 2008

  12. Systematic review of health state utility values for acute myeloid leukemia

    OpenAIRE

    Forsythe, Anna; Brandt, Patricia S; Dolph, Mike; Patel, Sachin; Rabe, Adrian Paul J; Tremblay, Gabriel

    2018-01-01

    Anna Forsythe,1 Patricia S Brandt,2 Mike Dolph,1 Sachin Patel,3 Adrian Paul J Rabe,1 Gabriel Tremblay1 1Purple Squirrel Economics, New York, NY, 2Novartis Pharmaceuticals, East Hanover, NJ, USA; 3Novartis Pharmaceuticals UK Limited, Frimley, Camberley, Surrey, UK Background: Cost-utility analyses for acute myeloid leukemia (AML) require health state utility values (HSUVs) in order to calculate quality-adjusted life-years (QALYs) for each health state. Aim: This study reviewed AML-related HSU...

  13. Internship report on palliative care at St Catherine's hospice

    OpenAIRE

    Monteiro, Andreia Marlene da Silva

    2016-01-01

    This report, performed in the context of the completion of the masters in Palliative Care, presents the activities and learning experiences that I have acquired during the months of training in the different settings of palliative care. This internship was performed at St Catherine’s Hospice (Inpatient unit, Day hospice and Community team) and with the National Health Service of East Surrey Hospital Specialist Palliative Care Team. Alongside the institutional involvement, internship activitie...

  14. The nuclear review. Proceedings

    International Nuclear Information System (INIS)

    Dimson, E.; Staunton, M.; Jeffrey, R.; Robinson, C.; O'Neill, M.

    1995-01-01

    Four contributions to a seminar held in February 1995 at the University of Surrey on the hearings for the government's review of the future role of nuclear generated electricity in the United Kingdom are brought together in this document. They provide analysis and policy recommendations from the standpoint of the nuclear industry, the political opposition and the academic world. Separate abstracts have been prepared for each paper. (UK)

  15. A portfolio of academic, therapeutic practice and research work : including an investigation of counselling psychologists' experience of the role of body in the therapeutic encounter

    OpenAIRE

    Kouloumbri, Maria

    2013-01-01

    This portfolio was submitted to the University of Surrey for the completion of the Doctorate (PsychO) in Psychotherapeutic and Counselling Psychology. It is comprised of three dossiers which reflect the academic, clinical and research work undertaken as part of this degree. The academic dossier consists of three essays. The first essay presents Freud's dream interpretation theory and Jung's dream theory and elaborates on the features of each theory respectively. The second e...

  16. Ways of seeing evaluation

    OpenAIRE

    Bryant, W; Wilson, L; Lawson, J

    2011-01-01

    Copyright @ 2011 Brunel University This report summarises the evaluation of Ways of Seeing, a community arts project funded by the Heritage Lottery Fund and hosted by the Lightbox, Woking, Surrey from 2008-11. The people involved have had remarkable experiences, choosing how to take part in each stage of preparations for a major public art exhibition. All those involved had disabilities, primarily arising from mental health issues but also including physical disabilities. The project was s...

  17. A novel technique to check the occlusion during the placement of stainless steel crowns under general anesthesia

    Directory of Open Access Journals (Sweden)

    Mohiddin Dimashkieh

    2015-01-01

    Full Text Available Stainless steel crowns are the restoration of choice for the treatment of badly decayed posterior teeth under general anesthesia. The evaluation of occlusion after the placement of these crowns, however, remains a difficult task. This paper outlines a technique to evaluate the occlusion of stainless steel crowns placed under general anesthesia using a specially designed tray and a fast setting polyvinyl siloxane bite registration material (Regisil® PB™, Dentsply, Surrey UK.

  18. The M1 Abrams Today and Tomorrow

    Science.gov (United States)

    2014-11-01

    counterinsurgency, but that, as noted in the new Army Capstone Concept, the Abram’s combination of high mobility and protect - ed firepower can at times prove...forced on Congress and the White House from the current massive federal deficits, will almost certainly foster an era of less for the Department of...Conroy, Heavy Metal, (Washington, DC: Potomac Books, 2005), 195-209. 19. Christopher F. Foss, Jane’s Armour and Artillery 2010- 2011 (Surrey, UK: HIS

  19. Perceived causes of differential attainment in UK postgraduate medical training: a national qualitative study

    OpenAIRE

    Woolf, Katherine; Rich, Antonia; Viney, Rowena; Needleman, Sarah; Griffin, Ann

    2016-01-01

    Objectives Explore trainee doctors? experiences of postgraduate training and perceptions of fairness in relation to ethnicity and country of primary medical qualification. Design Qualitative semistructured focus group and interview study. Setting Postgraduate training in England (London, Yorkshire and Humber, Kent Surrey and Sussex) and Wales. Participants 137 participants (96 trainees, 41 trainers) were purposively sampled from a framework comprising: doctors from all stages of training in g...

  20. Synthesis and spectroscopic study of 2,7-diethylamino-2-oxo-2H-chromen-3-yl benzothiazole-6-sulfonyl chlorides and its derivatives

    Directory of Open Access Journals (Sweden)

    Salma M.Z. Al-Kindy

    2017-02-01

    The electronic absorption and emission spectra of the label and its derivatives in organic solvents of different polarity, micellar systems and in aqueous buffered media are investigated. The label and its derivatives exhibited more or less the same excitation and emission wavelength around 470 and 520 nm, respectively. Maximum fluorescence quantum yield for aniline derivative was observed in ethyl acetate while minimum yield was observed in water. In micellar systems, maximum quantum yield was observed in the presence of Tw-20 for the label while proline derivative gave maximum enhancement in the presence of Tw-80. The results reflect the importance of medium effect on the fluorescence intensity and molar absorptivity of the label and its derivatives.

  1. Improvement of a Mixture Experiment Model Relating the Component Proportions to the Size of Nanonized Itraconazole Particles in Extemporary Suspensions

    Energy Technology Data Exchange (ETDEWEB)

    Pattarino, Franco; Piepel, Gregory F.; Rinaldi, Maurizio

    2018-05-01

    The Foglio Bonda et al. (2016) (henceforth FB) paper discussed the use of mixture experiment design and modeling methods to study how the proportions of three components in an extemporaneous oral suspension affected the mean diameter of drug particles (the response variable of interest). The three components were itraconazole (ITZ), Tween 20 (TW20), and Methocel® E5 (E5). After publication of the FB paper, the second author of this corrigendum (not an author of the original paper) contacted the corresponding author to point out some errors as well as insufficient explanations in parts of the paper. This corrigendum was prepared to address these issues. The authors of the original paper apologize for any inconveniences to readers.

  2. Reviews

    Directory of Open Access Journals (Sweden)

    Derek Law

    2003-12-01

    Full Text Available Peter Jarvis is Professor of Continuing Education at the University of Surrey and a distinguished authority in this field. In this work he attempts to analyse what constitutes a 'real university' and whether the social changes which have impacted on traditional universities and the growth of other types of university represent a crisis and/or a failure to meet societal needs. Corporate universities have grown into a major business because the traditional university failed to meet the demands of corporate business for education and training. He stresses the need for universities to be true to their own identity in the face of such pressure.

  3. Speaker emotion recognition: from classical classifiers to deep neural networks

    Science.gov (United States)

    Mezghani, Eya; Charfeddine, Maha; Nicolas, Henri; Ben Amar, Chokri

    2018-04-01

    Speaker emotion recognition is considered among the most challenging tasks in recent years. In fact, automatic systems for security, medicine or education can be improved when considering the speech affective state. In this paper, a twofold approach for speech emotion classification is proposed. At the first side, a relevant set of features is adopted, and then at the second one, numerous supervised training techniques, involving classic methods as well as deep learning, are experimented. Experimental results indicate that deep architecture can improve classification performance on two affective databases, the Berlin Dataset of Emotional Speech and the SAVEE Dataset Surrey Audio-Visual Expressed Emotion.

  4. Nuclear physics research report 1988

    International Nuclear Information System (INIS)

    1988-01-01

    The paper presents the 1988 Nuclear Physics Research Report for the University of Surrey, United Kingdom. The report includes both experimental nuclear structure physics and theoretical nuclear physics research work. The experimental work has been carried out predominantly with the Nuclear Structure Facility at the SERC Daresbury Laboratory, and has concerned nuclear shapes, shape coexistence, shape oscillations, single-particle structures and neutron-proton interaction. The theoretical work has involved nuclear reactions with a variety of projectiles below 1 GeV per nucleon incident energy, and aspects of hadronic interactions at intermediate energies. (U.K.)

  5. Intermarried couples, mental health and psychosocial well-being

    DEFF Research Database (Denmark)

    Singla, Rashmi; Holm, Dagny

    2012-01-01

    up in visibly ethnically different households. In Lutz, V., & L. Supik (Eds.), Framing intersectionality: Debates on a multi-faceted concept in gender studies. Surrey: Ashgate]. The analysis indicates that internal, personal and family aspects, such as realistic plans, mixing everyday practices...... and focussing on the fun part, are in interplay with external aspects such as formal and informal acceptance of the intermarriage in society, dominant gender roles, recognition and inclusion for the mixed couples. Recognition of the significance of these aspects and practices is important for promoting positive...

  6. The elemental analysis of staple foods for children in Tanzania as a step to the improvement of their nutrition and health

    Energy Technology Data Exchange (ETDEWEB)

    Mohammed, Najat K. [Department of Physics, School of Electronics and Physical Sciences, University of Surrey, Guildford, Surrey GU2 7XH (United Kingdom)], E-mail: njkassim@yahoo.com; Spyrou, Nicholas M. [Department of Physics, School of Electronics and Physical Sciences, University of Surrey, Guildford, Surrey GU2 7XH (United Kingdom)

    2009-03-15

    The objective of this study was to evaluate the contents of essential elements in the two staple foods (rice and maize flour) consumed by children in Tanzania as a possible selection measure for high nutrient foods in order to combat malnutrition. Samples were analysed using proton-induced X-ray emission (PIXE) at the University of Surrey Ion Beam Centre. The mean concentrations of elements determined in the two staple foods are presented and compared with the mean concentrations published in the literature.

  7. Public perceptions of aspects of radioactive waste management

    International Nuclear Information System (INIS)

    1985-04-01

    The paper concerns a study of peoples' attitude towards the siting of radioactive waste repositories, carried out by the University of Surrey, United Kingdom. The work has been commissioned by the Department of the Environment as part of its radioactive waste management research programme. The people taking part were asked to mark on a map of Great Britain places they felt radioactive waste repositories would be least objectionable. The degree to which people worried about the technology and the management of radioactive waste disposal was monitored. Questions were asked about storage, disposal and transportation aspects, and about present and future worries. (UK)

  8. Parameters. US Army War College Quarterly. Volume 24, Number 2, Summer 1994

    Science.gov (United States)

    1994-01-01

    Azuela’s out-of-print novel, The Underdogs , which provides remarkable insights into how Mexico’s revolutionary warriors degenerated. 7. RicardalHuch, Der...Department of the Army, FM 100-15, Corps Operations, September 1989, p. 3-7. 40. Christopher F. Foss, Janes Armour andArtillery 1991-92 (12th ed.; Surrey...Photohistory of World War One. London: Arms and Armour (Dist. in US by Sterling Publishing Co.), 1994. 240 pp. $19.95. Henig, Ruth. The Origins of the

  9. Changes in lifestyle habits and behaviours are associated with weight loss maintenance in members of a commercial weight loss organisation

    OpenAIRE

    Stubbs, RJ; McConnon, A; Gibbs, M; Raats, M; Whybrow, S

    2012-01-01

    This analysis examined the lifestyle correlates of weight loss maintenance in 1428 participants of a slimming organisation, who had been members for a mean SD of 16 16 months, had lost 13.8% 9.2% weight and were trying to maintain, or increase, their weight loss during a subsequent 6 month study period. Data were collected as part of the DiOGenes study(1). Ethical approval was given by the University of Surrey Ethics Committee. Adults were recruited between August 2006 and July 2008 from Slim...

  10. Get a head in telepresence: active vision for remote intervention

    International Nuclear Information System (INIS)

    Pretlove, J.

    1996-01-01

    Despite advances in robotic systems, many tasks needing to be undertaken in hazardous environments require human control. The risk to human life can be reduced or minimised using an integrated control system comprising an active controllable stereo vision system and a virtual reality head-mounted display. The human operator is then immersed in and can interact with the remote environment in complete safety. An overview is presented of the design and development of just such an advanced, dynamic telepresence system, developed at the Department of Mechanical Engineering at the University of Surrey. (UK)

  11. The elemental analysis of staple foods for children in Tanzania as a step to the improvement of their nutrition and health

    International Nuclear Information System (INIS)

    Mohammed, Najat K.; Spyrou, Nicholas M.

    2009-01-01

    The objective of this study was to evaluate the contents of essential elements in the two staple foods (rice and maize flour) consumed by children in Tanzania as a possible selection measure for high nutrient foods in order to combat malnutrition. Samples were analysed using proton-induced X-ray emission (PIXE) at the University of Surrey Ion Beam Centre. The mean concentrations of elements determined in the two staple foods are presented and compared with the mean concentrations published in the literature

  12. Characteristics of Multihole Collimator Gamma Camera Simulation Modeled Using MCNP5

    International Nuclear Information System (INIS)

    Saripan, M. I.; Mashohor, S.; Adnan, W. A. Wan; Marhaban, M. H.; Hashim, S.

    2008-01-01

    This paper describes the characteristics of the multihole collimator gamma camera that is simulated using the combination of the Monte Carlo N-Particles Code (MCNP) version 5 and in-house software. The model is constructed based on the GCA-7100A Toshiba Gamma Camera at the Royal Surrey County Hospital, Guildford, Surrey, UK. The characteristics are analyzed based on the spatial resolution of the images detected by the Sodium Iodide (NaI) detector. The result is recorded in a list-mode file referred to as a PTRAC file within MCNP5. All pertinent nuclear reaction mechanisms, such as Compton and Rayleigh scattering and photoelectric absorption are undertaken by MCNP5 for all materials encountered by each photon. The experiments were conducted on Tl-201, Co-57, Tc-99 m and Cr-51 radio nuclides. The comparison of full width half maximum value of each datasets obtained from experimental work, simulation and literature are also reported in this paper. The relationship of the simulated data is in agreement with the experimental results and data obtained in the literature. A careful inspection at each of the data points of the spatial resolution of Tc-99 m shows a slight discrepancy between these sets. However, the difference is very insignificant, i.e. less than 3 mm only, which corresponds to a size of less than 1 pixel only (of the segmented detector)

  13. Smartphone qualification & linux-based tools for CubeSat computing payloads

    Science.gov (United States)

    Bridges, C. P.; Yeomans, B.; Iacopino, C.; Frame, T. E.; Schofield, A.; Kenyon, S.; Sweeting, M. N.

    Modern computers are now far in advance of satellite systems and leveraging of these technologies for space applications could lead to cheaper and more capable spacecraft. Together with NASA AMES's PhoneSat, the STRaND-1 nanosatellite team has been developing and designing new ways to include smart-phone technologies to the popular CubeSat platform whilst mitigating numerous risks. Surrey Space Centre (SSC) and Surrey Satellite Technology Ltd. (SSTL) have led in qualifying state-of-the-art COTS technologies and capabilities - contributing to numerous low-cost satellite missions. The focus of this paper is to answer if 1) modern smart-phone software is compatible for fast and low-cost development as required by CubeSats, and 2) if the components utilised are robust to the space environment. The STRaND-1 smart-phone payload software explored in this paper is united using various open-source Linux tools and generic interfaces found in terrestrial systems. A major result from our developments is that many existing software and hardware processes are more than sufficient to provide autonomous and operational payload object-to-object and file-based management solutions. The paper will provide methodologies on the software chains and tools used for the STRaND-1 smartphone computing platform, the hardware built with space qualification results (thermal, thermal vacuum, and TID radiation), and how they can be implemented in future missions.

  14. Making connections and building resilience: Developing workshops with undergraduates

    Directory of Open Access Journals (Sweden)

    Julia Anthoney

    2017-09-01

    Full Text Available While defining resilience is recognised as complex with recent research highlighting the disparity of interpretations, there is however, a common appreciation of the wide range of contributory factors impacting on students’ resilience within the Higher Education sector. These can include but are not limited to, an increasingly competitive environment for graduate jobs, increased financial pressure from student tuition fees, alongside the more traditional concerns of moving away from home and transitioning towards greater independence. Building on previous research at the University of Surrey with high achieving students, this paper outlines the development and delivery of a student focused workshop designed to enable the participants to build their understanding of resilience using different but complementary pedagogic approaches: LEGO® SERIOUS PLAY® and Concept Mapping. The case study included within this paper demonstrates one student’s reflection of the workshop and previous experiences which have contributed to their own resilience. What has become apparent at the University of Surrey, and more broadly within the UK Higher Education sector, is that universities have a vital role to play in fostering positive mindsets amongst students and developing strong and resilient independent learners.

  15. Reduced frequency and severity of residential fires following delivery of fire prevention education by on-duty fire fighters: cluster randomized controlled study.

    Science.gov (United States)

    Clare, Joseph; Garis, Len; Plecas, Darryl; Jennings, Charles

    2012-04-01

    In 2008, Surrey Fire Services, British Columbia, commenced a firefighter-delivered, door-to-door fire-prevention education and smoke alarm examination/installation initiative with the intention of reducing the frequency and severity of residential structure fires in the City of Surrey. High-risk zones within the city were identified and 18,473 home visits were undertaken across seven temporal delivery cohorts (13.8% of non-apartment dwellings in the city). The frequency and severity of fires pre- and post- the home visit intervention was examined in comparison to randomized high-risk cluster controls. Overall, the frequency of fires was found to have reduced in the city overall, however, the reduction in the intervention cohorts was significantly larger than for controls. Furthermore, when fires did occur within the intervention cohorts, smoke detectors were activated more frequently and the fires were confined to the object of origin more often post-home visits. No equivalent pattern was observed for the cluster control. On-duty fire fighters can reduce the frequency and severity of residential fires through targeted, door-to-door distribution of fire prevention education in high-risk areas. Copyright © 2012 Elsevier Ltd. All rights reserved.

  16. Interaction of intense femtosecond laser pulses with high-Z solids

    International Nuclear Information System (INIS)

    Zhidkov, A.; Sasaki, Akira; Utsumi, Takayuki; Fukumoto, Ichirou; Tajima, Toshiki; Yoshida, Masatake; Kondo, Kenichi

    2000-01-01

    A plasma irradiated by an intense very short pulse laser can be an ultimate high brightness source of incoherent inner-shell X-ray emission of 1-30 keV. The recently developed 100 TW, 20 fs laser facility in JAERI can make considerable enhancement here. To show this a hybrid model combining hydrodynamics and collisional particle-in-cell simulations is applied. Effect of laser prepulse on the interaction of an intense s-polarized femtosecond, ∼20/40 fs, laser pulse with high-Z solid targets is studied. A new absorption mechanism originating from the interaction of the laser pulse with plasma waves excited by the relativistic component of the Lorentz force is found to increase the absorption rate over 30% even for a very short laser pulse. The obtained hot electron temperature exceeds 0.5-1 MeV at optimal conditions for absorption. Results of the simulation for lower laser pulse intensities are in good agreement with the experimental measurements of the hot electron energy distribution. (author)

  17. Alginate edible films containing microencapsulated lemongrass oil or citral: effect of encapsulating agent and storage time on physical and antimicrobial properties.

    Science.gov (United States)

    Alarcón-Moyano, Jessica K; Bustos, Rubén O; Herrera, María Lidia; Matiacevich, Silvia B

    2017-08-01

    Active edible films have been proposed as an alternative to extend shelf life of fresh foods. Most essential oils have antimicrobial properties; however, storage conditions could reduce their activity. To avoid this effect the essential oil (EO) can be microencapsulated prior to film casting. The aim of this study was to determine the effects of the type of encapsulating agent (EA), type of EO and storage time on physical properties and antimicrobial activity of alginate-based films against Escherichia coli ATCC 25922. Trehalose (TH), Capsul ® (CAP) and Tween 20 (Tw20) were used as EA. Lemongrass essential oil (LMO) and citral were used as active agents. The results showed that the type of EA affected the stability of the film forming-emulsions as well as the changes in opacity and colour of the films during storage but not the antimicrobial activity of them. Both microencapsulated EOs showed a prolonged release from the alginate films during the 28 days of storage. Trehalose was selected to encapsulate both active compounds because the films made with this microencapsulated EA showed the greatest physical stability and the lowest color variation among all the films studied.

  18. Perspectives on medicine adherence in service users and carers with experience of legally sanctioned detention and medication: a qualitative study

    Directory of Open Access Journals (Sweden)

    Chambers M

    2013-08-01

    Full Text Available Iris Gault,1 Ann Gallagher,2 Mary Chambers31Faculty of Health and Social Care Sciences, Kingston University and St George's University of London, Kingston, Surrey, UK; 2International Centre for Nursing Ethics, School of Health and Social Care, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK; 3Faculty of Health and Social Care Sciences, Kingston University and St George's University of London, St George's University of London, Tooting, London, UKAim: To explore and analyze perceptions of service users and caregivers on adherence and nonadherence to medication in a mental health care context.Background: Mental health medication adherence is considered problematic and legal coercion exists in many countries.Design: This was a qualitative study aiming to explore perceptions of medication adherence from the perspective of the service user (and their caregiver, where possible.Participants: Eighteen mental health service users (and six caregivers with histories of medication nonadherence and repeated compulsory admission were recruited from voluntary sector support groups in England.Methods: Data were collected between 2008 and 2010. Using qualitative coding techniques, the study analyzed interview and focus group data from service users, previously subjected to compulsory medication under mental health law, or their caregivers.Results: The process of medication adherence or nonadherence is encapsulated in an explanatory narrative. This narrative constitutes participants' struggle to negotiate acceptable and effective routes through variable quality of care. Results indicated that service users and caregivers eventually accepted the reality of their own mental illness and their need for safety and treatment. They perceived the behavior of professionals as key in their recovery process. Professionals could be enabling or disabling with regard to adherence to medication.Conclusion: This study investigated service user

  19. Ion channelling analysis of pre-amorphised silicon diodes using a nuclear microprobe

    International Nuclear Information System (INIS)

    Thornton, J.; Paus, K.C.

    1988-01-01

    Aligned and random ion channelling analysis was performed on p + n diode structures in silicon, with the Surrey nuclear microprobe. Three different types of diode were investigated, each pre-amorphised by a different ion (Si + , Ge + or Sn + ) before the p + region was formed by BF 2 + implantation. The ion channelling measurements are presented and compared with previously published electrical measurements on these diodes. Relatively large residual disorder and junction leakage currents were found for the Si + pre-amorphised diodes; however, all the diodes were leaky. The results are consistent with dislocation loops within the depletion regions of the diodes causing both the residual disorder and the large leakage currents. Cross-sectional transmission electron microscopy studies support this model. (author)

  20. Effects of Substituting Palm Olein with Carbohydrates on Insulin Sensitivity: A Review

    International Nuclear Information System (INIS)

    Kim-Tiu, T.; Faun, C.L.

    2016-01-01

    The role of palm olein on insulin resistance, which predisposes to disease progression of type 2 diabetes, is unclear. This article summarises the effects of substituting palm olein with carbohydrates on insulin sensitivity. Two intervention studies have reported conflicting findings. The RISCK (Reading, Imperial, Surreys, Cambridge and King's) study suggested that saturated fat-enriched diet consisting of mainly palm oil and milk fat did not differ from both high and low glycemic carbohydrates on insulin sensitivity in subjects at risk of developing metabolic syndrome. However, another study reported reduced insulin sensitivity after a diet enriched with palm olein and butter compared with high carbohydrate intake. No epidemiological data exists in this context. More clinical trials using solely palm olein in this area are needed. Further well-controlled large scale studies are needed to furnish the information on palm olein replacement with carbohydrates in diabetes prevention. (author)

  1. Optical MEMS for earth observation payloads

    Science.gov (United States)

    Rodrigues, B.; Lobb, D. R.; Freire, M.

    2017-11-01

    An ESA study has been taken by Lusospace Ltd and Surrey Satellite Techonoly Ltd (SSTL) into the use of optical Micro Eletro-Mechanical Systems (MEMS) for earth Observation. A review and analysis was undertaken of the Micro-Optical Electro-Mechanical Systems (MOEMS) available in the market with potential application in systems for Earth Observation. A summary of this review will be presented. Following the review two space-instrument design concepts were selected for more detailed analysis. The first was the use of a MEMS device to remove cloud from Earth images. The concept is potentially of interest for any mission using imaging spectrometers. A spectrometer concept was selected and detailed design aspects and benefits evaluated. The second concept developed uses MEMS devices to control the width of entrance slits of spectrometers, to provide variable spectral resolution. This paper will present a summary of the results of the study.

  2. An inverse method for calculation of thermal inertia and heat gain in air conditioning and refrigeration systems

    International Nuclear Information System (INIS)

    Fayazbakhsh, M.A.; Bagheri, F.; Bahrami, M.

    2015-01-01

    Highlights: • An inverse method is proposed to calculate thermal inertia in HVAC-R systems. • Real-time thermal loads are estimated using the proposed intelligent algorithm. • Calculation algorithm is validated with on-site measurements. • Freezer duty cycle data are extracted only based on temperature measurements. - Abstract: A new inverse method is proposed for estimation of thermal inertia and heat gain in air conditioning and refrigeration systems using on-site temperature measurements. The method is applied on a walk-in freezer room of a restaurant in Surrey, British Columbia, Canada during one week of its regular operation. The thermal inertia and instantaneous heat gain are calculated and the results are validated using actual information of the materials inside the freezer room. The proposed method can be implemented in intelligent control systems designed for new and existing HVAC-R systems to improve their overall energy efficiency and reduce their environmental impacts

  3. Sedimentary and faunal sequence of the Wadhurst clay Wealden in boreholes at Wadhurst Park, Sussex

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, F W; Bazley, R A.B.; Shephard-Thorn, E R

    1967-01-01

    Three boreholes sunk at Wadhurst Park, Sussex, provide a virtually complete section through the Wadhurst Clay (Wealden, Lower Cretaceous) in its type area. Full lithological logs of the boreholes with discussions of rock types, sedimentary features and depositional environments are given. It is suggested the sediments were deposited under shallow-water lagoonal conditions which varied from fresh-water to brackish and possibly marine. The succession of ostracod assemblages as found in the boreholes is recorded and compared with that found in the Warlingham (Surrey), Chilcombe Down No. 1 (Hampshire) and Kingsclere No. 1 (Hampshire) boreholes. Ostracods including a number of new species and subspecies, all belonging to the genus Cypridea, are described together with notes on the morphology of that genus. (22 refs.)

  4. Hydrail : a parade Canada can lead

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, S. [Mooresville-South Iredell Economic Development Corp., NC (United States). Hydrogen Economy Advancement Team

    2007-07-01

    This paper suggested that Canada can play a leading role in the development of hydrogen railways. Canadian scientists were among the first to test and develop the world's first hydrogen locomotive, and Canadian rail firms are now in a position to play a prominent role in the passenger hydrogen rail equipment market. A hydrogen railway will be built as part of Vancouver's 2010 winter olympics infrastructure. The Fraser Valley Heritage Railway Society is planning to use hydrogen to power vintage inter-urban trolley cars connecting Surrey communities. A Canadian manufactured hybrid locomotive will be modified to create the world's first hydrogen rail switch engine. It was concluded that hydrogen's storage capacity makes it an enabling technology for other other renewable energy technologies. Future hydrogen storage technologies will probably be hybridized with fuel cells in highly efficient applications. 1 ref.

  5. Small satellites and their regulation

    CERN Document Server

    Jakhu, Ram S

    2014-01-01

    Since the launch of UoSat-1 of the University of Surrey (United Kingdom) in 1981, small satellites proved regularly to be useful, beneficial, and cost-effective tools. Typical tasks cover education and workforce development, technology demonstration, verification and validation, scientific and engineering research as well as commercial applications. Today the launch masses range over almost three orders of magnitude starting at less than a kilogram up to a few hundred kilograms, with budgets of less than US$ 100.00 and up to millions within very short timeframes of sometimes less than two years. Therefore each category of small satellites provides specific challenges in design, development and operations. Small satellites offer great potentials to gain responsive, low-cost access to space within a short timeframe for institutions, companies, regions and countries beyond the traditional big players in the space arena. For these reasons (particularly the low cost of construction, launch and operation), small (m...

  6. Power system design and in orbit performance of Algeria's first micro satellite Alsat-1

    Energy Technology Data Exchange (ETDEWEB)

    Bekhti, Mohammed [Centre National des Techniques Spatiales, BP13, Arzew 31200 (Algeria); Sweeting, M.N. [Centre for Satellite Engineering Research, University of Surrey, Guildford, Surrey GU2 7XH (United Kingdom)

    2008-07-15

    On the 28th November 2002, Algeria's first enhanced micro satellite was launched into a 686 km low earth orbit onboard a Cosmos 3M rocket from Plesetsk. The spacecraft was designed, manufactured and launched as a technology transfer programme between the National Centre of Space Techniques (CNTS) Algeria and Surrey Satellite Technology Limited (SSTL) United Kingdom in the timescale of 18 months. This paper will describe the design and in orbit performance of the mission power system, stressing the decisions taken in order to meet the mission requirements within the 18 months, concept to launch programme. Most of the design and construction techniques used in the production of the Alsat-1 power system were based on SSTL heritage over the years. It will be shown how off the shelf components either for the generation or storage of the onboard energy can be applied successfully to such missions. (author)

  7. Retention of fission products in air filters

    International Nuclear Information System (INIS)

    Sobnack, R.

    1986-01-01

    The plume from the Chernobyl nuclear reactor reached London in the morning of 1st May. Less than two weeks later, the Physics Department, University of Surrey, reported a measurable level of radioactivity in air filters. On 15th May air filters from within the air conditioning plant of the Radioisotope Department at the London Hospital were removed for radiation checks. Crude tests with a geiger counter gave readings of 5-10 times higher than background levels. Gamma-ray spectroscopy of the departmental air filters (AF1) using a 127 mm NaI detector revealed a pattern characteristic of emissions of fission products from a nuclear reactor. Another air filter (AF2), from the home of a member of staff, was much less active. Because of the complexity of the gamma-ray spectrum and the relatively high level of emission from the departmental air filter, a thorough investigation was carried out using a high purity germanium detector. (author)

  8. Blind source separation advances in theory, algorithms and applications

    CERN Document Server

    Wang, Wenwu

    2014-01-01

    Blind Source Separation intends to report the new results of the efforts on the study of Blind Source Separation (BSS). The book collects novel research ideas and some training in BSS, independent component analysis (ICA), artificial intelligence and signal processing applications. Furthermore, the research results previously scattered in many journals and conferences worldwide are methodically edited and presented in a unified form. The book is likely to be of interest to university researchers, R&D engineers and graduate students in computer science and electronics who wish to learn the core principles, methods, algorithms, and applications of BSS. Dr. Ganesh R. Naik works at University of Technology, Sydney, Australia; Dr. Wenwu Wang works at University of Surrey, UK.

  9. The successful treatment of vocal cord dysfunction with low-dose amitriptyline – including literature review

    Directory of Open Access Journals (Sweden)

    VA Varney

    2009-11-01

    Full Text Available VA Varney1, H Parnell1, J Evans1, NT Cooke1, J Lloyd2, J Bolton31Department of Respiratory Medicine, 2Department of Speech and Language Therapy, 3Department of Liaison Psychiatry, St Helier Hospital, Carshalton, Surrey, UKAbstract: Vocal cord dysfunction is an asthma mimic. Diagnosis of this condition requires a high index of suspicion if unnecessary treatments are to be avoided. We describe the findings from our case series of 62 patients (age range 18 to 90 years in whom the diagnosis was confirmed. Our findings show low-dose amitriptyline to be very effective in 90% of cases, with rapid benefit for those patients whose symptoms had been present for less than 12 months. This treatment, in conjunction with psycho-therapeutic and behavioral therapies may reduce unnecessary hospital admissions. Future studies may show whether this treatment regimen may reduce demands on the speech and language therapists.Keywords: vocal cord dysfunction, asthma, amitriptyline, wheeze, anxiety

  10. Secure Autonomous Automated Scheduling (SAAS). Rev. 1.1

    Science.gov (United States)

    Walke, Jon G.; Dikeman, Larry; Sage, Stephen P.; Miller, Eric M.

    2010-01-01

    This report describes network-centric operations, where a virtual mission operations center autonomously receives sensor triggers, and schedules space and ground assets using Internet-based technologies and service-oriented architectures. For proof-of-concept purposes, sensor triggers are received from the United States Geological Survey (USGS) to determine targets for space-based sensors. The Surrey Satellite Technology Limited (SSTL) Disaster Monitoring Constellation satellite, the UK-DMC, is used as the space-based sensor. The UK-DMC's availability is determined via machine-to-machine communications using SSTL's mission planning system. Access to/from the UK-DMC for tasking and sensor data is via SSTL's and Universal Space Network's (USN) ground assets. The availability and scheduling of USN's assets can also be performed autonomously via machine-to-machine communications. All communication, both on the ground and between ground and space, uses open Internet standards

  11. CERN@school shoots for the stars

    CERN Multimedia

    Katarina Anthony

    2011-01-01

    CERN technology will be taking a stellar journey as the Langton Ultimate Cosmic ray Intensity Detector (LUCID) is launched into space in 2012. LUCID has been designed by students from the CERN@school programme using Timepix chips from the Medipix Collaboration at CERN.   CERN@school students present LUCID.  In today’s educational environment, a pioneering school physics programme that involves students in authentic research seems unlikely. But in the UK, the CERN@school programme is providing the resources for school students to do just that. “We develop projects which allow students to work alongside scientists and engineers before they go to university,” says Becky Parker, head of the Langton Star Centre and founder of the CERN@school programme. “Thanks to these programmes, students can make a genuine contribution to global scientific research. LUCID is the culmination of three years of efforts by the students.” Surrey Satellite Tech...

  12. Investigation of drug-release polymers using nuclear reaction analysis and particle induced X-ray emission

    International Nuclear Information System (INIS)

    Smith, R.W.; Massingham, Gary; Clough, A.S.

    2003-01-01

    The diffusion of water into the developmental drug-release polymer addition cured silicone has been investigated using 3 He ion scanning micro-beam techniques developed at the University of Surrey. Polymer samples loaded with 15% by weight of the drug chlorohexidine diacetate were immersed in a water based phosphate buffered saline solution for times of 1 hour, 1 day, 1 week and 1 month. The results showed that as the water diffused into the polymer it associated with the drug allowing its release by diffusion through the network formed by water filled pores. Future improvements to the techniques are discussed including the use of an array of CdZnTe detectors

  13. Delivery of core medical training: the role of a local faculty group.

    Science.gov (United States)

    Black, David; Dewhurst, Graeme

    2011-10-01

    All physicians who are training young doctors of the future recognise the current challenge of doing this in the NHS. The recently published Temple Report documents the challenge and some of the solutions. For Kent, Surrey and Sussex (KSS) Deanery, one of the responses was to implement a new structure and process at local level--the local faculty groups (LFGs)--to ensure appropriate curriculum delivery. This paper sets out the history, structure and purpose of LFGs, describes what happens during a LFG meeting in both open and closed sessions and presents feedback of learning from two years in action across 11 acute trusts in the South East Coast (SEC) strategic health authority area. The experience of trainers in SEC is that the local faculty group structure and associated processes is one strand in the more effective delivery of education in the current NHS environment.

  14. [Nutrition habits of students of University of Economics in Wroclaw].

    Science.gov (United States)

    Kowalska, Anna

    2010-01-01

    The aim of a paper was an assessment of Wroclaw University of Economics students nutritional habits. Purposeful sample group selection was opted in this surrey. The method Ch2 was used to analyses questionnaire data. Obtained results confirm, that most of student don't nourish properly. Irregular breakfast before leaving home is the most frequent incorrectness, as well as irregular second breakfast or resignation from second breakfast at work or on classes breaks. Dinners consumption for large group of polled was irregular too. Lack of proper nutrition habits among young people is the cause of this state. Young people haste and limited finance causing that most of polled. Students consume only one course meal, mostly preparing by themselves. Basic foodstuffs i.e. meat, fishes, poultry, dairy products and fruits and vegetables or more often. Large group of students (especially women) declared eating sweets to often.

  15. Turn and face the change

    Energy Technology Data Exchange (ETDEWEB)

    O' Mahoney, H.

    2000-06-01

    The core industries ultimately governing the trading and distribution of dry bulk cargoes are undergoing radical changes brought on by deregulation and other factors. One consequence of this is that companies providing turnkey engineering are required to adapt to a new business environment. For example, Binnie Black & Veatch based in Redhill, Surrey, UK offers comprehensive services to utilities, power generating companies, developers, independent power projects and leading institutions operating in the new competitive power generating environment. Another consultancy group, Mouchel, was recently appointed to provide advice to the power and industrial systems division of Hitachi, Japan for the new Visag coal-based independent power project for Hinduja National Power Company, to provide electricity to Andhra Pradesh in eastern India. MET-CHEM Canada provides specialised services to mining, metallurgy and mineral processing industries. Materials handling equipment suppliers such as Svedala and Vairport Engineering have also had to expand their range of products and services. 3 photos.

  16. Promoting space research and applications in developing countries through small satellite missions

    Science.gov (United States)

    Sweeting, M.

    The high vantage-point of space offers very direct and tangible benefits to developing countries when carefully focused upon their real and particular communications and Earth observation needs. However, until recently, access to space has been effectively restricted to only those countries prepared to invest enormous sums in complex facilities and expensive satellites and launchers: this has placed individual participation in space beyond the sensible grasp of developing countries. However, during the last decade, highly capable and yet inexpensive small satellites have been developed which provide an opportunity for developing countries realistically to acquire and operate their own independent space assets - customized to their particular national needs. Over the last 22 years, the Surrey Space Centre has pioneered, developed and launched 23 nano-micro-minisatellite missions, and has worked in partnership with 12 developing countries to enable them to take their first independent steps into space. Surrey has developed a comprehensive and in-depth space technology know-how transfer and 'hands-on' training programme that uses a collaborative project comprising the design, construction, launch and operation of a microsatellite to acquire an indigenous space capability and create the nucleus of a national space agency and space industry. Using low cost small satellite projects as a focus, developing countries are able to initiate a long term, affordable and sustainable national space programme specifically tailored to their requirements, that is able to access the benefits derived from Earth observation for land use and national security; improved communications services; catalyzing scientific research and indigenous high-technology supporting industries. Perhaps even more important is the long-term benefit to the country provided by stimulating educational and career opportunities for your scientists and engineers and retaining them inside the country rather the

  17. H.S.W. Massey. Life, work personality and characteristics

    International Nuclear Information System (INIS)

    Bates, D.R.

    1985-01-01

    Harrie Stewart Wilson Massey was born in Melbourne in 1908 and died at home in Surrey in 1983. This brief biography begins with his boyhood in Australia and his schooling both in Melbourne and at Cambridge and then discusses his achievements and positions in the academic and scientific communities before returning to his Cambridge period to discuss his accomplishments there in greater detail. Among them are his experiments on electron diffraction by atom; the first Born approximation; electron exchange; electron-molecule collisions; collisions between atomic systems and transport phenomena in gases; and nuclear collisions. The paper concludes by describing Massey's personality and characteristics and then lists an 11-page bibliography of his journal papers and books

  18. Oral healthcare challenges for older Punjabi-speaking immigrants.

    Science.gov (United States)

    MacEntee, Michael I; Wong, Sabrina T; Smith, André; Beattie, B Lynn; Brondani, Mario; Bryant, S Ross; Graf, Peter; Soheilipour, Shimae

    2014-06-01

    This study explored how older Punjabi-speaking South-Asian immigrants (four focus groups; 33 participants) in Surrey, British Columbia, perceive oral health and related problems. Content analysis revealed two umbrella themes: (a) interpretations of mouth conditions and (b) challenges to oral health. The umbrella themes had four sub-themes: damage caused by heat (wai), disturbances caused by caries, coping with dentures, and quality of life. Three challenges were considered: home remedies, Western dentistry, and difficulties accessing dentists. Participants explained oral diseases in terms of a systemic infection (resha), and preferred to decrease imbalances of wai in the mouth with home remedies from India. We conclude that older Punjabi-speaking immigrants interpret oral health and disease in the context of both Western and Ayurvedic traditions, and that they manage dental problems with a mix of traditional remedies supplemented, if possible, by elective oral health care in India, and by emergency dental care in Canada.

  19. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2002-04-01

    Full Text Available -Greg Bankoff, Alfred W. McCoy, Lives at the margin; Biography of Filipinos obscure, ordinary and heroic. Madison, Wisconsin: Center for Southeast Asian Studies, University of Wisconsin-Madion, v + 481 pp. -Greg Bankoff, Clive J. Christie, Ideology and revolution in Southeast Asia 1900-1980; Political ideas of the anti-colonial era. Richmond, Surrey: Curzon Press, xi + 236 pp. -René van den Berg, Videa P. de Guzman ,Grammatical analysis; Morphology, syntax, and semantics; Studies in honor of Stanley Starosta. Honolulu: University of Hawai'i Press, xv + 298 pp. [Oceanic Linguistics Special Publication 29.], Byron W. Bender (eds -Wayne A. Bougas, Daniel Perret ,Batu Aceh; Warisan sejarah Johor. Kuala Lumpour: École francaise d'Extrême Orient, Johor Baru: Yayasan Warisan Johor, xxxviii + 510 pp., Kamarudin Ab. Razak (eds -Freek Colombijn, Benedict R. O.G. Anderson, Violence and the state in Suharto's Indonesia. Ithaca, New York: Cornell University, Southeast Asia Program, 247 pp. [Studies on Southeast Asia 30.] -Harold Crouch, Stefan Eklöf, Indonesian politics in crisis; The long fall of Suharto, 1996-98. Copenhagen: Nodic Institute of Asian Studies, 1999, xi + 272 pp. [NIAS Studies in Contemporary Asia 1.] -John Gullick, Kumar Ramakrishna, Emergency propaganda; The winning of Malayan hearts and minds 1948-1958. Richmond, Surrey: Curzon, 2002, xii + 306 pp. -Han Bing Siong, Daniel S. Lev, Legal evolution and political authority in Indonesia; Selected essays. The Hague: Kluwer Law International, 2000, 349 pp., The Hague, London, Boston: Kluwer International. -David Henley, Laura Lee Junker, Raiding, trading, and feasting; The political economy of Philippine chiefdoms. Honolulu: University of Hawai'i Press, 1999, ix + 477 pp. -R.D. Hill, Jonathan Rigg, Southeast Asia; The human landscape of modernization and development. London: Routledge, 1997, xxv + 326 pp. -Adrian Horridge, Gene Ammarell, Bugis navigation. New Haven, Connecticut: Yale

  20. PIXE and ion beam analysis in forensics

    International Nuclear Information System (INIS)

    Bailey, Melanie; Warmenhoven, John; Chrislopher, Matt; Kirkby, Karen; Palitsin, Vladimir; Grime, Geoff; Jeynes, Chris; Jones, Brian; Wenn, Roger

    2013-01-01

    Full text: University of Surrey has, for the past four years, collaborated with police institutions from across Europe and the rest of the world lo scope potential applications of ion beam analysis (IBA) in forensic science. In doing this we have consulted practitioners across a range of forensic disciplines, and critically compared IBA with conventional characterisation techniques to investigate the areas in which IBA can add evidential value. In this talk, the results of this feasibility study will be presented, showing the types of sample for which IBA shows considerable promise. We will show how a combination of PIXE with other IBA techniques (EBS, PIGE, MeV-SIMS) can be used to give unprecedented characterisation of forensic samples and comment on the significance of these results for forensic casework. We will also show cases where IBA not appear to add any significant improvement over conventional techniques. (author)

  1. X-ray phase contrast imaging of the bone-cartilage interface

    International Nuclear Information System (INIS)

    Ismail, E.C.; Kaabar, W.; Garrity, D.; Gundogdu, O.; Bradley, D.A.; Bunk, O.; Pfeiffer, F.; Farquharson, M.J.

    2008-01-01

    Full text: Synovial joints articulate in a lubricating environment, the system providing for smooth articulation. The articular cartilage overlying the bone consists of a network of collagen fibres. This network is essential to cartilage integrity, suffering damage in degenerative joint disease such as osteoarthritis. At Surrey and also in work conducted by this group at the Paul Scherrer Institute (PSI) synchrotron site we have been applying a number of techniques in studying the bone-cartilage interface and of changes occurring in this with disease. One technique attracting particular interest is X-ray phase contrast imaging, yielding information on anatomical features that manifest from the large scale organisation of collagen and the mineralised phase contained within the collagen fibres in the deep cartilage zone. This work will briefly review some of the basic supporting physics and then shows some of the images and other results that we have obtained to-date

  2. Semiautonomous teleoperation system with vision guidance

    Science.gov (United States)

    Yu, Wai; Pretlove, John R. G.

    1998-12-01

    This paper describes the ongoing research work on developing a telerobotic system in Mechatronic Systems and Robotics Research group at the University of Surrey. As human operators' manual control of remote robots always suffer from reduced performance and difficulties in perceiving information from the remote site, a system with a certain level of intelligence and autonomy will help to solve some of these problems. Thus, this system has been developed for this purpose. It also serves as an experimental platform to test the idea of using the combination of human and computer intelligence in teleoperation and finding out the optimum balance between them. The system consists of a Polhemus- based input device, a computer vision sub-system and a graphical user interface which communicates the operator with the remote robot. The system description is given in this paper as well as the preliminary experimental results of the system evaluation.

  3. An exploration into pedagogic frailty: Transitioning from face-to-face to online

    Directory of Open Access Journals (Sweden)

    Irina Niculescu

    2017-09-01

    Full Text Available Pedagogic frailty and concept mapping can simultaneously encourage personal and organisational change by supporting critical reflection and resilience. These ideas are nascent within higher education institutions and currently, at the University of Surrey, are only developed through face-to-face sessions. This revealed the need for a scalable intervention which engages academics with the discourse on introspective and professional development practices. In response, we have created the design for a blended programme of online foundation for concept mapping leading to face-to-face workshops to explore the pedagogic frailty model. This paper will discuss some significant challenges arising from transitioning self-reflective practices from face-to-face to online spaces. In the process, we will consider ways in which learning design can take the learner context into account.

  4. Capacity building in emerging space nations: Experiences, challenges and benefits

    Science.gov (United States)

    Jason, Susan; da Silva Curiel, Alex; Liddle, Doug; Chizea, Francis; Leloglu, Ugur Murat; Helvaci, Mustafa; Bekhti, Mohammed; Benachir, Djouad; Boland, Lee; Gomes, Luis; Sweeting, Martin

    2010-09-01

    This paper focuses on ways in which space is being used to build capacity in science and technology in order to: Offer increasing support for national and global solutions to current and emerging problems including: how to improve food security; resource management; understanding the impacts of climate change and how to deal with them; improving disaster mitigation, management and response. Support sustainable economic development. We present some of the experiences, lessons learned and benefits gained in capacity building projects undertaken by Surrey Satellite Technology Ltd. and our partners from developing and mature space nations. We focus on the Turkish, Algerian and Nigerian know-how and technology transfer programmes which form part of the first Disaster Monitoring Constellation (DMC) in orbit. From the lessons learned on Surrey's know-how and technology transfer partnership programmes, it is clear that space technology needs to be implemented responsibly as part of a long-term capacity building plan to be a sustainable one. It needs to be supported with appropriate policy and legal frameworks, institutional development, including community participation, human resources development and strengthening of managerial systems. In taking this on board, DMC has resulted in a strong international partnership combining national objectives, humanitarian aid and commerce. The benefits include: Ownership of space-based and supporting ground assets with low capital expenditure that is in line with national budgets of developing nations. Ownership of data and control over data acquisition. More for the money via collaborative consortium. Space related capacity building in organisations and nations with the goal of sustainable development. Opportunities for international collaboration, including disaster management and relief.

  5. A comparative life cycle assessment of diesel and compressed natural gas powered refuse collection vehicles in a Canadian city

    International Nuclear Information System (INIS)

    Rose, Lars; Hussain, Mohammed; Ahmed, Syed; Malek, Kourosh; Costanzo, Robert; Kjeang, Erik

    2013-01-01

    Consumers and organizations worldwide are searching for low-carbon alternatives to conventional gasoline and diesel vehicles to reduce greenhouse gas (GHG) emissions and their impact on the environment. A comprehensive technique used to estimate overall cost and environmental impact of vehicles is known as life cycle assessment (LCA). In this article, a comparative LCA of diesel and compressed natural gas (CNG) powered heavy duty refuse collection vehicles (RCVs) is conducted. The analysis utilizes real-time operational data obtained from the City of Surrey in British Columbia, Canada. The impact of the two alternative vehicles is assessed from various points in their life. No net gain in energy use is found when a diesel powered RCV is replaced by a CNG powered RCV. However, significant reductions (approximately 24% CO 2 -equivalent) in GHG and criteria air contaminant (CAC) emissions are obtained. Moreover, fuel cost estimations based on 2011 price levels and a 5-year lifetime for both RCVs reveal that considerable cost savings may be achieved by switching to CNG vehicles. Thus, CNG RCVs are not only favorable in terms of reduced climate change impact but also cost effective compared to conventional diesel RCVs, and provide a viable and realistic near-term strategy for cities and municipalities to reduce GHG emissions. - Highlights: ► Life cycle analysis is performed on two alternative refuse collection vehicle technologies. ► Real-time operational data obtained by the City of Surrey in British Columbia are utilized. ► The life cycle energy use is similar for diesel and CNG RCVs. ► A 24% reduction of GHG emissions (CO 2 -equivalent) may be realized by switching from diesel to CNG. ► CNG RCVs are estimated to be cost effective and may lead to reduced fuel costs.

  6. Adsorption mechanisms of L-Glutathione on Au and controlled nano-patterning through Dip Pen Nanolithography

    Energy Technology Data Exchange (ETDEWEB)

    Calborean, A., E-mail: adrian.calborean@gmail.com [National Institute for Research and Development of Isotopic and Molecular Technologies, Donat 67-103, 400293 Cluj-Napoca (Romania); Martin, F.; Marconi, D.; Turcu, R.; Kacso, I.E.; Buimaga-Iarinca, L. [National Institute for Research and Development of Isotopic and Molecular Technologies, Donat 67-103, 400293 Cluj-Napoca (Romania); Graur, F. [Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Babeş 8, 400012 Cluj-Napoca (Romania); Turcu, I. [National Institute for Research and Development of Isotopic and Molecular Technologies, Donat 67-103, 400293 Cluj-Napoca (Romania)

    2015-12-01

    Dip Pen Nanolithography technique has been employed for patterning L-Glutathione tripeptide (L-y-glutamyl-L-cysteinyl-glycine) nanostructures at specific locations on metallic Au(111) substrate. The formed supramolecular architectures were designed through straight lines and dots serving as precursors for building blocks assemblies in nano-bio-electronics applications or as template structures for functionalized particles in the form of host–guest networks. Tween 20 polyoxyethylene surfactant concentrations ranging from 0.005 to 0.1% (v/v) into initial L-Glutathione tripeptide (2 mg mL{sup −1}) ink solutions were sequentially tested for the improvement of the ink delivery process and to assure an optimum uniformity and homogeneity over the patterned space. A strong relationship was found between the coated atomic force microscope (AFM) cantilever within the highly effective Tween 20 activator adjuvant and the molecular diffusion along concentration gradients. An increase in the driving force for ink transport from the AFM tip has been demonstrated within the highest 0.1% (v/v) TW 20 surfactant concentration, favoring the patterning of GSH molecules routinely with sub-100 nm resolution. Self-assembled monolayers of GSH were also fabricated and characterized in the light of X-ray photoemission spectroscopy (XPS) and ellipsometric optical measurements. Adsorption from water of L-Glutathione to the gold substrate is proven to be made by the thiol group of cysteine. Theoretical DFT approaches were applied for quantum chemical studies dedicated to electronic processes underneath molecular GSH/Au(111) systems. - Highlights: • Controlled nano-patterning of L-Glutathione was performed on Au by DPN. • Tween 20 was used for increasing driving force of molecular ink transport. • SAM's formation has described the adsorption mechanisms of L-Glutathione on Au. • Electronic properties of hybrid GSH/Au(111) structures were investigated by DFT. • Validation of

  7. The Effect of Endometriosis Symptoms on Absenteeism and Presenteeism in the Workplace and at Home.

    Science.gov (United States)

    Soliman, Ahmed M; Coyne, Karin S; Gries, Katharine S; Castelli-Haley, Jane; Snabes, Michael C; Surrey, Eric S

    2017-07-01

    ; P Women who experienced 3 endometriosis symptoms concurrently lost a significantly greater number of employment hours because of absenteeism and presenteeism compared with those experiencing 1 or 2 symptoms (P women and employers manage endometriosis so as to reduce productivity loss. The design and financial support for this study was provided by AbbVie. AbbVie participated in data analysis, interpretation of data, review, and approval of the manuscript. Coyne and Gries are employees of Evidera- Evidence, Value & Access by PPD and were paid scientific consultants for AbbVie in connection with this study. Soliman, Castelli-Hayley, and Snabes are AbbVie employees and may own AbbVie stock or stock options. Surrey is affiliated with Colorado Center for Reproductive Medicine and was paid by AbbVie as a consultant for this project. Surrey serves as a consultant for AbbVie outside of this project. All authors participated in data analysis and interpretation, and contributed to the development of the manuscript. The authors maintained control over the final contents of the manuscript and the decision to publish. Study concept and design were contributed by Soliman, Coyne, Gries, and Castelli-Haley. Soliman, Castelli-Haley, Coyne, and Gries collected the data, and data interpretation was performed by Snabes, Surrey, Soliman, Coyne, and Gries. The manuscript was written and revised by Soliman, Coyne, and Gries, along with the other authors.

  8. “You can get there from here”: Advanced low cost propulsion concepts for small satellites beyond LEO

    Science.gov (United States)

    Baker, Adam M.; da Silva Curiel, Alex; Schaffner, Jake; Sweeting, Martin

    2005-07-01

    Small satellites have historically been forced to use low cost propulsion, or to do without in order to maintain low cost. Since 1999 an increasing number of SSTL's customers have demanded the capability to precisely position and subsequently manoeuvre their satellites, driven largely by the current attraction of small satellite constellations such as Disaster Monitoring (DMC), which require propulsion for launcher injection error correction, drag compensation, constellation phasing and proximity manoeuvring and rendezvous. SSTL has successfully flight qualified a simple, low cost propulsion system based on a low power (15-100 W) resistojet employing green propellants such as butane and xenon, and demonstrated key constellation manoeuvres. The system is capable of up to 60 m/s deltaV and will be described here. The SSTL low power resistojet is however limited by a low Isp ( ˜50s for Xenon in the present design, and ˜100s with nitrogen and butane) and a slow reaction time ( 10min warm-up required). An increasing desire to apply small satellite technology to high deltaV missions while retaining the low cost aspect demands new solutions. 'Industry standard' solutions based on cryogenic propulsion, or toxic, carcinogenic storable propellants such as hydrazine/nitrogen oxides combination are not favourable for small satellite missions developed within SSTL's low cost engineering environment. This paper describes a number of strawman missions with high deltaV and/or precision manoeuvring requirements and some low cost propulsion solutions which have been explored at the Surrey Space Centre to meet future needs: Deployment of a complex constellation of nano- or pico-satellites from a secondary launch to a new orbit. The S3TV concept has been developed to allow deployment up to 12 payloads from an 'off-the-shelf' thrust tube, using a restartable nitrous oxide hybrid engine, operating in a dual mode with resistojets for attitude control. Orbit transfer of an enhanced

  9. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2004-01-01

    Full Text Available -Barbara Watson Andaya, Susan Blackburn, Love, sex and power; Women in Southeast Asia. Clayton VIC: Monash Asia Institute, 2001, iv + 144 pp. [Monash papers on Southeast Asia 55.] -Kathryn Gay Anderson, Juliette Koning ,Women and households in Indonesia; Cultural notions and social practices. Richmond, Surrey: Curzon, 2000, xiii + 354 pp. [Nordic Institute of Asian studies, studies in Asian topics 27.], Marleen Nolten, Janet Rodenburg (eds -Greg Bankoff, Takeshi Kawanaka, Power in a Philippine city. Chiba: Institute of developing economies, 2002, 118 pp. [IDE Occasional papers series 38.] -René van den Berg, John Lynch ,The Oceanic languages. Richmond, Surrey: Curzon, 2002, xvii + 924 pp., Malcolm Ross, Terry Crowley (eds -H.J.M. Claessen, Douglas Oliver, Polynesia in early historic times. Honolulu: Bess Press, 2002, 305 pp. -Harold Crouch, Andrew Rosser, The politics of economic liberalisation in Indonesia; State, market and power. Richmond, Surrey: Curzon, 2002, xv + 232 pp. -Hans Hägerdal, Arend de Roever, De jacht op sandelhout; De VOC en de tweedeling van Timor in de zeventiende eeuw. Zutphen: Walburg Pers, 2002, 383 pp. -Fiona Harris, Lorraine V. Aragon ,Structuralism's transformations; Order and revision in Indonesian and Malaysian societies; Paper written in honor of Clark E. Cunningham. Tempe AZ: Arizona State University Press, 1999, lxii + 402 pp., Susan D. Russell (eds -David Henley, Christiaan Heersink, Dependence on green gold: A socio-economic history of the Indonesian coconut island Selayar. Leiden: KITlV Press, 1999, xviii + 371 pp. [Verhandelingen 184.] -David Hicks, James T. Siegel ,Southeast Asia over three generations; Essays presented to Benedict R.O'G. Anderson 2003, 398 pp. Ithaca NY: Cornell University Southeast Asia program. [Studies on Southeast Asia 36.], Audrey R. Kahin (eds -Janny de Jong, L. de Jong, The collapse of a colonial society; The Dutch in Indonesia during the second world war. With an introduction by

  10. A conceptual framework of patient satisfaction with a pharmacy adherence service.

    Science.gov (United States)

    van den Berg, Melandi; Donyai, Parastou

    2014-02-01

    Patients do not adhere to their medicines for a host of reasons which can include their underlying beliefs as well as the quality of their interactions with healthcare professionals. One way of measuring the outcome of pharmacy adherence services is to assess patient satisfaction but no questionnaire exists that truly captures patients' experiences with these relatively new services. Our objective was to develop a conceptual framework specific to patient satisfaction with a community pharmacy adherence service based on criteria used by patients themselves. The study was based in community pharmacies in one large geographical area of the UK (Surrey). All the work was conducted between October 2008 and September 2010. This study involved qualitative non-participant observation and semi-structured interviewing. We observed the recruitment of patients to the medicines use review (MUR) service and also actual MUR consultations (7). We also interviewed patients (15). Data collection continued until no new themes were identified during analysis. We analysed interviews to firstly create a comprehensive account of themes which had significance within the transcripts, then created sub-themes within super-ordinate categories. We used a structure-process-outcome approach to develop a conceptual framework relating to patient satisfaction with the MUR. Favourable ethical opinion for this study was received from the NHS Surrey Research Ethics Committee on 2nd June 2008. Five super-ordinate themes linked to patient satisfaction with the MUR service were identified, including relationships with healthcare providers; attitudes towards healthcare providers; patients' experience of health, healthcare and medicines; patients' views of the MUR service; the logistics of the MUR service. In the conceptual framework, structure was conceptualised as existing relationships, environment, and time; process was conceptualised as related to recruitment and consultation stages; and outcome as two

  11. Investigation of an outbreak of vomiting in nurseries in South East England, May 2012.

    Science.gov (United States)

    Nicholls, M; Purcell, B; Willis, C; Amar, C F L; Kanagarajah, S; Chamberlain, D; Wooldridge, D; Morgan, J; McLauchlin, J; Grant, K A; Harvey-Vince, L; Padfield, M; Mearkle, R; Chow, J Y

    2016-02-01

    On 30 May 2012, Surrey and Sussex Health Protection Unit was called by five nurseries reporting children and staff with sudden onset vomiting approximately an hour after finishing their lunch that day. Over the following 24 h 50 further nurseries supplied by the same company reported cases of vomiting (182 children, 18 staff affected). Epidemiological investigations were undertaken in order to identify the cause of the outbreak and prevent further cases. Investigations demonstrated a nursery-level attack rate of 55 out of 87 nurseries (63·2%, 95% confidence interval 52·2-73·3). Microbiological tests confirmed the presence of Bacillus cereus in food and environmental samples from the catering company and one nursery. This was considered microbiologically and epidemiologically consistent with toxin from this bacterium causing the outbreak. Laboratory investigations showed that the conditions used by the caterer for soaking of pearl haricot beans (known as navy bean in the USA) used in one of the foods supplied to the nurseries prior to cooking, was likely to have provided sufficient growth and toxin production of B. cereus to cause illness. This large outbreak demonstrates the need for careful temperature control in food preparation.

  12. Positron depth profiling

    International Nuclear Information System (INIS)

    Coleman, P.

    2001-01-01

    Wide-ranging studies of defects below the surface of semiconductor structures have been performed at the University of Bath, in collaboration with the University of Surrey Centre for Ion Beam Applications and with members of research teams at a number of UK universities. Positron implantation has been used in conjunction with other spectroscopies such as RBS-channeling and SIMS, and electrical characterisation methods. Research has ranged from the development of a positron-based technique to monitor the in situ annealing of near-surface open-volume defects to the provision of information on defects to comprehensive diagnostic investigations of specific device structures. We have studied Si primarily but not exclusively; e.g., we have investigated ion-implanted SiC and SiO 2 /GaAs structures. Of particular interest are the applications of positron annihilation spectroscopy to ion-implanted semiconductors, where by linking ion dose to vacancy-type defect concentration one can obtain information on ion dose and uniformity with a sensitivity not achievable by standard techniques. A compact, user-friendly positron beam system is currently being developed at Bath, in collaboration with SCRIBA, with the intention of application in an industrial environment. (orig.)

  13. Elemental concentration in hair and nail from a selected population group in the Machakos District of Keyna

    International Nuclear Information System (INIS)

    Otham, I.; Spyrou, N.M.

    1979-01-01

    Hair and nail samples were collected in the Iveti location of the Machakos District, Kenya by the University of Surrey Africa Study Group. The population chosen was one suggested by the World Health Organization because a large section of it is involved in agricultural activities, and it is supposedly free from industrial effluents. Also, since the District is where the 4th-year Nairobi medical students do their field training, health profiles may be more readily obtained. It was hoped that the study would yield normal ranges of elements for this population and provide information about their environment. Results for the concentrations of 11 elements (Na, Mg, Cl, Ca, V, Mn, Cu, Br, Sr, Ba and Hg) in hair and toe-nails obtained by instrumental neutron activation analysis for about one quarter (71 subjects) of the total 'normal' sample, divided by sex and age into four groups, are presented. These are treated as preliminary findings. In addition, the use of techniques in electron microscopy is advocated and discussed in evaluating hair and nails as indicators of environmental health. (author)

  14. A review of the evaluation of TENORM levels at the produced water lagoon of the Minagish oil field using high-resolution gamma-ray spectrometry

    Science.gov (United States)

    Shams, H. M.; Bradley, D. A.; Alshammari, H.; Regan, P. H.

    2017-11-01

    An evaluation of the specific activity concentrations associated with technologically enhanced naturally occurring radioactive materials (TENORM) and anthropogenic radionuclides has been undertaken as part of a systematic study to provide a radiological map of the outer boundary of the produced water lagoon located in the Minagish oil field in the south west of the State of Kuwait. The lagoon contains material from the discharge of produced water which is a by-product of oil production in the region. The lagoon samples were prepared and placed into sealed, marinelli beakers for a full gamma-ray spectrometric analysis using a high-resolution, low-background, high-purity germanium detection systems at the University of Surrey Environmental Radioactivity Laboratory. Of particular interest are the calculation of the activity concentrations associated with members of the decay chains following decays of the primordial radionuclides of the 238U chain (226Ra, 214Pb, 214Bi) and the 232Th chain (228Ra, 228Ac, 212Pb, 212Bi, 208Tl), and the enhanced concentrations of radium isotopes. This conference paper presents an overview summary of the experimental samples which have been measured and the analysis techniques applied, including isotopic correlation plots across the sample region. The result shows the expected significant increase in 226Ra (and progeny) concentrations compared to the NORM values previously reported by our group for the overall terrain in Kuwait.

  15. Bigger, Brighter, Bluer-Better?Current light-emitting devices- adverse sleep properties and preventative strategies.

    Directory of Open Access Journals (Sweden)

    Paul eGringras

    2015-10-01

    Full Text Available ObjectiveIn an effort to enhance the efficiency, brightness and contrast of light-emitting (LE devices during the day, displays often generate substantial short-wavelength (blue-enriched light emissions that can adversely affect sleep. We set out to verify the extent of such short-wavelength emissions, produced by a tablet (iPad Air, e-reader (Kindle Paperwhite 1st generation and smartphone (iPhone 5s and to determine the impact of strategies designed to reduce these light emissions. SettingUniversity of Surrey dedicated chronobiology facility.MethodsFirstly, the spectral power of all the light-emitting (LE devices was assessed when displaying identical text. Secondly, we compared the text output with that of ‘Angry Birds’-a popular top 100 ‘App Store’ game. Finally we measured the impact of two strategies that attempt to reduce the output of short-wavelength light emissions. The first strategy employed an inexpensive commercially available pair of orange-tinted ‘blue-blocking’ glasses. The second tested an app designed to be ‘sleep-aware’ whose designers deliberately attempted to reduce blue-enriched light emissions.ResultsAll the LE devices shared very similar enhanced blue-light peaks when displaying text. This included the output from the backlit Kindle Paperwhite device. The spectra when comparing text to the Angry Birds game were also very similar, although the

  16. Disposal and handling of nuclear steam generator chemical cleaning wastes

    International Nuclear Information System (INIS)

    Larrick, A.P.; Schneidmiller, D.

    1978-01-01

    A large number of pressurized water nuclear reactor electrical generating plants have experienced a corrosion-related problem with their steam generators known as denting. Denting is a mechanical deformation of the steam generator tubes that occurs at the tube support plates. Corrosion of the tube support plates occurs within the annuli through which the tubes pass and the resulting corrosion oxides, which are larger in volume than the original metal, compress and deform the tubes. In some cases, the induced stresses have been severe enough to cause tube and/or support cracking. The problem was so severe at the Turkey Point and Surrey plants that the tubing is being replaced. For less severe cases, chemical cleaning of the oxides, and other materials which deposit in the annuli from the water, is being considered. A Department of Energy-sponsored program was conducted by Consolidated Edison Co. of New York which identified several suitable cleaning solvents and led to in-plant chemical cleaning pilot demonstrations in the Indian Point Unit 1 steam generators. Current programs to improve the technology are being conducted by the Electric Power Research Institute, and the three PWR NSSS vendors with the assistance of numerous consultants, vendors, and laboratories. These programs are expected to result in more effective, less corrosive solvents. However, after a chemical cleaning is conducted, a large problem still remains- that of disposing of the spent wastes. The paper summarizes some of the methods currently available for handling and disposal of the wastes

  17. An analysis of the death of main malignant tumor of inhabitants in nuclear power station area

    International Nuclear Information System (INIS)

    Ma Mingqiang; Lu Zunrong; Zheng Wen; Chen Guopei

    1997-01-01

    The authors reported the analysis on the death millimeter situation of inhabitants living around one nuclear power station during pre-operation period of 1988∼1991 and 1992∼1993 operating period. Total surrey population in six years is 2585521 person year, gross malignant tumour death rate is 116.38 x 10 -5 , calibrated death rate is 97.04 x 10 -5 , of which male is 129.20 x 10 -5 , female 65.39 x 10 -5 . An extremely significant difference is noted statistically. Individual annual death rate is 112.00 x 10 -5 , 120.15 x 10 -5 , 125.17 x 10 -5 , 116.45 x 10 -5 , 105.42 x 10 -5 and 119.16 x 10 -5 respectively. The statistical difference was no marked. The highest mortality rate is from the liver cancer, then from the cancer of the lung, of the stomach and of the esophagus. 94 cases died from leukemia with a mortality rate of 3.64 x 10 -5 , and 5 died from thyroid carcinoma, accounting for 0.17% of the total death cases

  18. Radio-iodine in thyroid glands of swans, farm animals and humans, also in algae and river water from the Thames Valley, England

    Energy Technology Data Exchange (ETDEWEB)

    Howe, J.R.; Lloyd, M.K.

    1986-01-01

    A highly sensitive counting system has been used to measure radio-iodine in environmental samples from the Thames Valley. Iodine-125 and occasionally iodine-131 have been found in the thyroid glands of most of the swans that have died on the River Thames, the River Wey and the Grand Union Canal, and in algae and water samples from the Thames and many of its tributaries. The presence of this activity is ascribed to the waste discarded into the drainage system by hospitals and research laboratories, reaching the rivers via the effluent from sewage treatment works. The Thames is used as a source of drinking water, particularly in London and its western approaches. Weed and water samples collected from river water abstraction points, reservoirs, tap water supplies, and animal water troughs fed from this supply all contained low levels of iodine-125. The drinking water route can account for the iodine-125 found in the thyroids of farm animals from west Surrey and in a few people living in London. The amounts found constitute a trivial radiation dose to man and animals as they are far below the acceptable limit of exposure for man.

  19. The outlook for oil prices in 1992 - results of a survey

    International Nuclear Information System (INIS)

    Hawdon, D.

    1992-01-01

    The eighth in a series of oil price expectation studies took place on 18th March 1992 at the Prospects for Oil Prices conference held at the University of Surrey. Thirty-one participants returned a questionnaire designed to elicit 12 month ahead and 5 year ahead price expectations. Respondents were asked to indicate their view of the likely price of oil in certain broad price ranges. These were selected to cover the wide variation of prices experienced since the early 1970s. The results show the 12 month's ahead expectations all clustered in the range $10 to $25 per barrel and $16-$20 as the median predicted price. In comparison with the 1991 expectations, a much higher proportion of respondents (77.4 as compared to 50% in 1991) gave $16-20 as their expected price range, whilst fewer expected prices to rise (19% compared with 46% in 1991). The stability of the 12 month ahead price expectations is a remarkable feature of a period which has witnessed much tension in the Middle East and in the former Soviet Union. This stability extends to the 5 year ahead forecasts as well. Here the median expectation is for prices to rise to the $21-25 per barrel range in money of the day terms though there is evidence of a growing scepticism about the oil market's ability to sustain higher prices in the long run. (author)

  20. Jet set pets: examining the zoonosis risk in animal import and travel across the European Union

    Directory of Open Access Journals (Sweden)

    Fooks AR

    2014-12-01

    Full Text Available Anthony R Fooks,1,2 Nicholas Johnson1 1Wildlife Zoonoses and Vector-Borne Diseases Research Group, Animal and Plant Health Agency, Addlestone, Surrey, 2Department of Clinical Infection, University of Liverpool, Liverpool, UK Abstract: Ownership of companion animals or pets is popular throughout the world. Unfortunately, such animals are susceptible to and potential reservoirs of zoonotic pathogens. Close proximity to and contact with pets can lead to human infections. The distribution of zoonotic diseases associated with companion animals such as dogs and cats is not uniform around the world, and moving animals between regions, countries, and continents carries with it the risk of relocating the pathogens they might harbor. Critical among these zoonotic diseases are rabies, echinococcosis, and leishmania. In addition, the protozoan parasites, Toxoplasma gondii and Giardia duodenalis, are also significant agents for human disease of pet origin. Considerable effort is applied to controlling movements of companion animals, particularly dogs, into the European Union. However, free movement of people and their pets within the European Union is a risk factor for the translocation of diseases and their vectors. This review considers the current distribution of some of these diseases, the risks associated with pet travel, and the controls implemented within Europe to prevent the free movement of zoonotic pathogens. Keywords: zoonosis, companion animal, rabies, alveolar echinococcosis, leishmania

  1. Interview with 2018 Hooke medal winner Andrew McAinsh.

    Science.gov (United States)

    2018-03-14

    Andrew McAinsh received his PhD from the University of Cambridge, UK, working in the laboratory of Steve Jackson on DNA damage and repair mechanisms in yeast. He then joined the laboratory of Peter Sorger as a Jane Coffin Childs Fellow to work as a post-doc on kinetochore biology at the Massachusetts Institute of Technology, Boston, USA. In 2005, he returned to the UK to establish his independent laboratory at the Marie Curie Research Institute, Surrey, before moving to the University of Warwick in 2009 to co-found the Centre for Mechanochemical Cell Biology (CMCB). Subsequently, Andrew was appointed Professor of Cell Biology and became a Wellcome Senior Investigator, and was awarded a Royal Society Wolfson Research Merit Award. He co-directs the MRC Doctoral Training Partnership in Interdisciplinary Biomedical Research, and in 2017 became Head of Division of Biomedical Sciences at Warwick Medical School. Andrew is interested in understanding how the chromosomal multi-protein complex, the kinetochore, ensures error-free chromosome segregation. He is the recipient of the 2018 Hooke medal, established to recognize an emerging leader in cell biology. The Hooke medal is awarded at the annual spring meeting of the British Society for Cell Biology (BSCB). © 2018. Published by The Company of Biologists Ltd.

  2. Sonnets and psalm

    Science.gov (United States)

    Mobley, Aaron

    Sonnets and Psalm investigates the relationships between the sacred nature of Psalm 91 and the secular nature of two sonnets, William Shakespeare's Sonnet 73 and Henry Howard, Earl of Surrey's Sonnet 8. Sonnets and Psalm exploits a dynamic that arises from the juxtaposition of disparate musical universes, choral and instrumental, and the unique and, at times, ineffable aesthetic qualities that emerge as a result of the intentional ordering of musical language and block structures. In a five movement form the listener is guided from vocal events painted on orchestral palettes, to solely instrumental movements, and back again. While the movements can stand independently of each other, there are ponderous transformations of material within and throughout the piece that create a thread that functions as a consistent generative unifying element. A recurrent utilization of motive, color, register, pitch-specific sonorities and gesture, enhances the unity of the work while exploiting the contradistinctive nature of each movement. Relational aspects of hidden and transformed materials from the Psalm and the sonnets (including the Mosaic movements) that are present throughout create a forward and back-relating dynamic. There is a programmatic element at work as well that in itself is a statement: after the sonnets and the mosaics, the listener is finally presented with the Psalm, a conclusion.

  3. Use of Calluna vulgaris to detect signals of nitrogen deposition across an urban-rural gradient

    Science.gov (United States)

    Power, S. A.; Collins, C. M.

    2010-05-01

    Densely populated cities can experience high concentrations of traffic-derived pollutants, with oxides of nitrogen and ammonia contributing significantly to the overall nitrogen (N) budget of urban ecosystems. This study investigated changes in the biochemistry of in situ Calluna vulgaris plants to detect signals of N deposition across an urban-rural gradient from central London to rural Surrey, UK. Foliar N concentrations and δ 15N signatures were higher, and C/N ratios lower, in urban areas receiving the highest rates of N deposition. Plant phosphorus (P) concentrations were also highest in these areas, suggesting that elevated rates of N deposition are unlikely to result in progressive P-limitation in urban habitats. Free amino acid concentrations were positively related to N deposition for asparagine, glutamine, glycine, phenylalanine, isoleucine, leucine and lysine. Overall, relationships between tissue chemistry and N deposition were similar for oxidised, reduced and total N, although the strength of relationships varied with the different biochemical indicators. The results of this study indicate that current rates of N deposition are having substantial effects on plant biochemistry in urban areas, with likely implications for the biodiversity and functioning of urban ecosystems.

  4. Environmental assessment of nuclear projects in Canada - process, participation, lessons learned

    International Nuclear Information System (INIS)

    Underdown, G.A.; Brown, P.A.; Morrison, R.W.

    1995-01-01

    This paper documents public participation in decision-making for five cases of nuclear-based projects in Canada. Two cases involve the application of the Federal Environmental Assessment and Review Process (EARP), a formal, non-judicial process for public involvement in projects with a potential environmental impact. It is being applied to the development of new Uranium mines and the disposal of used nuclear fuels. The siting of radioactive waste facilities, generally unwanted by the communities, presents many difficult challenges which needs to be addressed before a project goes through the EARP process. An open, consultative, community-based approach to decision-making about siting is being applied in the three cases: Port Hope, Scarborough and Surrey. A number of lessons have been learned, the most important that there is a need to establish an acceptable process that includes 'getting the science right' on a project before attempting to find a site. The EARP, in most cases, provides a good mechanism for the sharing of information about a potential between the proponents and the public as long as there are no major unresolved contentious issues such as the unwanted siting of a waste facility in a particular community. 19 refs

  5. An exploration of student midwives' language to describe non-formal learning in professional practice.

    Science.gov (United States)

    Finnerty, Gina; Pope, Rosemary

    2005-05-01

    The essence of non-formal learning in midwifery practice has not been previously explored. This paper provides an in-depth analysis of the language of a sample of student midwives' descriptions of their practice learning in a range of clinical settings. The students submitted audio-diaries as part of a national study (Pope, R., Graham. L., Finnerty. G., Magnusson, C. 2003. An investigation of the preparation and assessment for midwifery practice within a range of settings. Project Report. University of Surrey). Participants detailed their learning activities and support obtained whilst working with their named mentors for approximately 10 days or shifts. The rich audio-diary data have been analysed using Discourse Analysis. A typology of non-formal learning (Eraut, M. 2000. Non-formal learning and implicit knowledge in professional work. British Journal of Educational Psychology 70, 113-136) has been used to provide a framework for the analysis. Non-formal learning is defined as any learning which does not take place within a formally organised learning programme (Eraut, M. 2000. Non-formal learning and implicit knowledge in professional work. British Journal of Educational Psychology 70, 113-136). Findings indicate that fear and ambiguity hindered students' learning. Recommendations include the protection of time by mentors within the clinical curriculum to guide and supervise students in both formal and non-formal elements of midwifery practice. This paper will explore the implications of the findings for practice-based education.

  6. Community concepts.

    Science.gov (United States)

    Yeung, Thomas; Bates, Tony

    2004-03-01

    Since the publication of "Sustainable Communities--building for the future", Government attention has focused largely on high-density affordable housing in the four "growth areas": Thames Gateway; Ashford; Milton Keynes--South Midlands, and London--Stansted--Cambridge. In this article, Thomas Yeung and Tony Bates suggest that a greater and more sustainable impact would be achieved if architects, planners, and developers considered the potential for community-based water and waste management and on-site energy generation and distribution right from the start of the project. In particular, they consider that the communal nature of hospitals, universities, and public/community housing provides a great opportunity for on-site renewable CHP and/or distributed heating, which could combine global environmental benefits with improved local amenities. They describe a simple model for prioritising energy management in the built environment, and draw on lessons learnt at ETRCL in Dagenham and BedZED in Surrey to offer a few recommendations for Government and developers. Tony Bates is the business development manager for Scott Wilson in the South East and is responsible for the promotion of sustainable communities through relationships with architects, developers, land owners and local authorities. Thomas Yeung leads the Energy Infrastructure Technologies group in Scott Wilson. This team offers an integrated approach to clean community-based energy generation, energy management, waste and water management, sustainable transport, and sustainable buildings/communities.

  7. What they don't know can hurt us

    International Nuclear Information System (INIS)

    Mays, C.

    1993-01-01

    ''A public information campaign to support a proposed national deep repository for low and intermediate level radioactive waste'' is the title of a research and development project funded by the Commission of the European Communities, DG 12. The primary objective of the project is to gain support in Cumbria (UK) for a radioactive waste repository at Sellafield through the dissemination of factual information in various forms accessible to the public. The repository information effort is a joint project of UK Nirex and BNFL. Data collection in survey and interview form will enable changes in support to be measured. Dr Peter Allen of Robens Institute, Surrey, carried out a first wave of local opinion research in June 1992. The present author carried out analysis of this data in comparison with French data, comparison reported below. A second objective is to generate information suitable for detailed consideration by other European Community Member States, through evaluation of the fit between public information needs, and strategies and methods applied by institutions in the United Kingdom and in France. The present researcher is primarily concerned with this second objective. The initiation of an information campaign in the nuclear field, as an example of risk communication, provides a favorable opportunity to examine and evaluate the presuppositions guiding institutional action. (author)

  8. Space instrumentation: physics and astronomy in harmony?

    International Nuclear Information System (INIS)

    Aderin, M

    2008-01-01

    Surrey Satellite Technology Limited was formed as a company in 1985 and has been involved in 23 small satellite missions, making it the most successful and experienced small satellite supplier in the world. The challenge of getting a satellite into space takes a dedicated multidisciplinary team of physicists and engineers working together to achieve a common goal. In this paper the author will look at the breakdown of the teams for a number of space projects including NigeriaSAT1; one of the satellites that make up the Disaster Monitoring Constellation (DMC), which produces high quality commercial images for monitoring agriculture and the environment as well as dedicating a proportion of it's time to disaster monitoring. Commercial projects like this will be contrasted to instruments such as the Integral Field Unit (IFU) for the NIRSpec instrument on the James Webb Space Telescope (JWST is the replacement for the Hubble Space telescope). Although both projects have been running through commercial contracts at SSTL, how does the final goal of the instrument influence the synergy between the physics and the engineering needed to make it, and what, if any, economic differences are seen?

  9. RankProdIt: A web-interactive Rank Products analysis tool

    Directory of Open Access Journals (Sweden)

    Laing Emma

    2010-08-01

    Full Text Available Abstract Background The first objective of a DNA microarray experiment is typically to generate a list of genes or probes that are found to be differentially expressed or represented (in the case of comparative genomic hybridizations and/or copy number variation between two conditions or strains. Rank Products analysis comprises a robust algorithm for deriving such lists from microarray experiments that comprise small numbers of replicates, for example, less than the number required for the commonly used t-test. Currently, users wishing to apply Rank Products analysis to their own microarray data sets have been restricted to the use of command line-based software which can limit its usage within the biological community. Findings Here we have developed a web interface to existing Rank Products analysis tools allowing users to quickly process their data in an intuitive and step-wise manner to obtain the respective Rank Product or Rank Sum, probability of false prediction and p-values in a downloadable file. Conclusions The online interactive Rank Products analysis tool RankProdIt, for analysis of any data set containing measurements for multiple replicated conditions, is available at: http://strep-microarray.sbs.surrey.ac.uk/RankProducts

  10. Williams syndrome and its cognitive profile: the importance of eye movements

    Directory of Open Access Journals (Sweden)

    Van Herwegen J

    2015-06-01

    Full Text Available Jo Van Herwegen Department of Psychology, Kingston University London, Surrey, UK Abstract: People with Williams syndrome (WS, a rare neurodevelopmental disorder that is caused by a deletion on the long arm of chromosome 7, often show an uneven cognitive profile with participants performing better on language and face recognition tasks, in contrast to visuospatial and number tasks. Recent studies have shown that this specific cognitive profile in WS is a result of atypical developmental processes that interact with and affect brain development from infancy onward. Using examples from language, face processing, number, and visuospatial studies, this review evaluates current evidence from eye-tracking and developmental studies and argues that domain general processes, such as the ability to plan or execute saccades, influence the development of these domain-specific outcomes. Although more research on eye movements in WS is required, the importance of eye movements for cognitive development suggests a possible intervention pathway to improve cognitive abilities in this population. Keywords: Williams syndrome, eye movements, face processing, language, number, visuospatial abilities

  11. Using the Stock Market to Teach Physics

    Science.gov (United States)

    Faux, David A.; Hearn, Stephen

    2004-11-01

    Students are interested in money. Personal finance is an important issue for most students, especially as they move into university education and take a greater control of their own finances. Many are also interested in stock markets and their ability to allow someone to make, and lose, large sums of money, with their interest fueled by the boom in technology-based stocks of 2000/2001 followed by their subsequent dramatic collapse and the publicizing of so-called "rogue-traders." There is also a much greater ownership of stocks by families following public offerings, stock-based savings products, and the ability to trade stocks online. Consequently, there has been a steady growth of finance and finance-related courses available within degree programs in response to the student demand, with many students motivated by the huge salaries commanded by those with a successful career in the financial sector. We report here details of a joint project between Charterhouse School and the University of Surrey designed to exploit the excitement of finance to teach elements of the high school (age 16-18) curriculum through modeling and simulation.

  12. An investigation into alleged 'hauntings'.

    Science.gov (United States)

    Wiseman, Richard; Watt, Caroline; Stevens, Paul; Greening, Emma; O'Keeffe, Ciarán

    2003-05-01

    In cases of alleged hauntings, a large number of seemingly trustworthy witnesses consistently report experiencing unusual phenomena (e.g. apparitions, sudden changes in temperature, a strong sense of presence) in certain locations. The two studies reported here explored the psychological mechanisms that underlie this apparent evidence of 'ghostly' activity. The experiments took place at two locations that have a considerable reputation for being haunted-Hampton Court Palace (Surrey, England) and the South Bridge Vaults (Edinburgh, Scotland). Both studies involved participants walking around these locations and reporting where they experienced unusual phenomena. Results revealed significantly more reports of unusual experiences in areas that had a reputation for being haunted. This effect was not related to participants' prior knowledge about the reputation of these areas. However, the location of participants' experiences correlated significantly with various environmental factors, including, for example, the variance of local magnetic fields and lighting levels. These findings strongly suggest that alleged hauntings may not necessarily represent evidence for 'ghostly' activity, but could be, at least in part, the result of people responding to 'normal' factors in their surroundings.

  13. First results from the TOPSAT camera

    Science.gov (United States)

    Greenway, Paul; Tosh, Ian; Morris, Nigel; Burton, Gary; Cawley, Steve

    2017-11-01

    The TopSat camera is a low cost remote sensing imager capable of producing 2.5 metre resolution panchromatic imagery, funded by the British National Space Centre's Mosaic programme. The instrument was designed and assembled at the Space Science & Technology Department of the CCLRC's Rutherford Appleton Laboratory (RAL) in the UK, and was launched on the 27th October 2005 from Plesetsk Cosmodrome in Northern Russia on a Kosmos-3M. The camera utilises an off-axis three mirror system, which has the advantages of excellent image quality over a wide field of view, combined with a compactness that makes its overall dimensions smaller than its focal length. Keeping the costs to a minimum has been a major design driver in the development of this camera. The camera is part of the TopSat mission, which is a collaboration between four UK organisations; QinetiQ, Surrey Satellite Technology Ltd (SSTL), RAL and Infoterra. Its objective is to demonstrate provision of rapid response high resolution imagery to fixed and mobile ground stations using a low cost minisatellite. The paper "Development of the TopSat Camera" presented by RAL at the 5th ICSO in 2004 described the opto-mechanical design, assembly, alignment and environmental test methods implemented. Now that the spacecraft is in orbit and successfully acquiring images, this paper presents the first results from the camera and makes an initial assessment of the camera's in-orbit performance.

  14. Emerging treatments for advanced pancreatic cancer: clinical potential of albumin-bound paclitaxel

    Directory of Open Access Journals (Sweden)

    Fontana E

    2014-06-01

    Full Text Available Elisa Fontana, Francesco Sclafani, David Cunningham Department of Medicine, The Royal Marsden NHS Foundation Trust, London and Surrey, UK Abstract: The management of pancreatic cancer has historically represented a major challenge for oncologists. The inherent aggressiveness of this tumor and the fibrotic features of the surrounding stromal tissue have significantly limited the impact of standard chemotherapy. Moreover, the paucity of available tumor tissue has hampered a better understanding of the biology of this disease as well as the development of new treatment strategies. Recently, the therapeutic landscape of metastatic pancreatic cancer has been enriched by two new combination regimens (FOLFIRINOX and gemcitabine-nab-paclitaxel which have been demonstrated to improve the outcome in patients with good performance status. Moreover, the peritumoral stroma has been increasingly recognized as a potential therapeutic target for this disease, and several new agents targeting stromal components are currently under investigation. In this paper, we review the current treatment options for advanced pancreatic cancer, highlight the role of the peritumoral stroma, and discuss the clinical potential of nab-paclitaxel and antistromal treatment strategies. Keywords: pancreatic cancer, nab-paclitaxel, stroma, SPARC

  15. Invasive Shrub Mapping in an Urban Environment from Hyperspectral and LiDAR-Derived Attributes.

    Science.gov (United States)

    Chance, Curtis M; Coops, Nicholas C; Plowright, Andrew A; Tooke, Thoreau R; Christen, Andreas; Aven, Neal

    2016-01-01

    Proactive management of invasive species in urban areas is critical to restricting their overall distribution. The objective of this work is to determine whether advanced remote sensing technologies can help to detect invasions effectively and efficiently in complex urban ecosystems such as parks. In Surrey, BC, Canada, Himalayan blackberry ( Rubus armeniacus ) and English ivy ( Hedera helix ) are two invasive shrub species that can negatively affect native ecosystems in cities and managed urban parks. Random forest (RF) models were created to detect these two species using a combination of hyperspectral imagery, and light detection and ranging (LiDAR) data. LiDAR-derived predictor variables included irradiance models, canopy structural characteristics, and orographic variables. RF detection accuracy ranged from 77.8 to 87.8% for Himalayan blackberry and 81.9 to 82.1% for English ivy, with open areas classified more accurately than areas under canopy cover. English ivy was predicted to occur across a greater area than Himalayan blackberry both within parks and across the entire city. Both Himalayan blackberry and English ivy were mostly located in clusters according to a Local Moran's I analysis. The occurrence of both species decreased as the distance from roads increased. This study shows the feasibility of producing highly accurate detection maps of plant invasions in urban environments using a fusion of remotely sensed data, as well as the ability to use these products to guide management decisions.

  16. Neutron activation techniques in the detection and measurement of environmental pollutants

    International Nuclear Information System (INIS)

    Spyrou, N.M.; Maheswaran, P.; Nagy, K.; Oezek, F.

    1976-01-01

    The Medical and Environmental Group at the University of Surrey has been involved for several years in the development and application of nuclear activation techniques to biomedical and environmental problems. One such project has been a study of air pollution in the city of Guildford, which requires a routine but quick analytical process for the detection of trace elements in the atmosphere in order to handle data with limited resources and manpower. The proposed method comprises cyclic irradiation and counting, followed by further counting on a low-energy photon detector and a Ge(Li) detector. The scheme concentrates on the measurement of short-lived isotopes. In order to test its efficacy it is compared with conventional activation experiments for irradiation times of 1 min, 10 min and 60 min; various types of filter papers and membranes, used for collection of the samples, are analysed under these conditions. The paper illustrates this comparison by analysis of NBS Standard Reference Material 1571 (Orchard Leaves) on Whatman grade 1 filter paper. The analysis of a typical Guildford sample is also shown. The technique enhances the detection of 38 Clsup(m)(0.74 s), 207 Pbsup(m)(0.8 s), 20 F(11.56 s), 77 Sesup(m)(17.5 s) and 110 Ag(24.4 s). (author)

  17. Achievement in Physics

    Science.gov (United States)

    1999-03-01

    Naomi Moran, a student at the Arnewood School, New Milton, Hampshire was the first recipient of the `Achievement in Physics' prize awarded by the South Central Branch of The Institute of Physics. Naomi received an award certificate and cheque for £100 from Dr Ruth Fenn, Chairman of the Branch, at the annual Christmas lecture held at the University of Surrey in December. She is pictured with Dr Fenn and Steve Beith, physics teacher at the Arnewood School.  Photo Figure 1. Naomi Moran receiving her award (photograph courtesy of Peter Milford). The award is intended to celebrate personal achievement in physics at any level at age 16-17 and is not restricted to those who gain the highest academic results. Schools across the county were invited to nominate suitable candidates; Naomi's nomination by the school's deputy head of science impressed the judges because of her ability to grasp the most difficult parts of the subject quickly, in addition to the fact that she took her AS-level science in year 11 when she was only 16. She is currently studying A-level physics, chemistry and mathematics and hopes to continue her studies at university later this year.

  18. X-ray phase contrast imaging of the bone-cartilage interface

    International Nuclear Information System (INIS)

    Ismail, Elna Che; Kaabar, W.; Garrity, D.; Gundogdu, O.; Bunk, O.; Pfeiffer, F.; Farquharson, M.J.; Bradley, D.A.

    2010-01-01

    Synovial joints articulate in a lubricating environment, the system providing for smooth articulation. The articular cartilage overlying the bone consists of a network of collagen fibres. This network is essential to cartilage integrity, suffering damage in degenerative joint disease such as osteoarthritis. At Surrey and also in work conducted by this group at the Paul Scherrer Institute (PSI) synchrotron site we have been applying a number of techniques to study the bone-cartilage interface and of changes occurring in this with disease. One of the techniques attracting particular interest is X-ray phase contrast imaging, yielding information on anatomical features that manifest from the large scale organisation of collagen and the mineralised phase contained within the collagen fibres in the deep cartilage zone. This work briefly reviews some of the basic supporting physics of X-ray phase contrast imaging and then shows example images of the articular surface and subchondral bone and other supporting results obtained to-date. Present results have been obtained on sections of bone not displaying evidence of an osteoarthritic lesion and can be used as a baseline against which diseased bone can be compared.

  19. X-ray phase contrast imaging of the bone-cartilage interface

    Energy Technology Data Exchange (ETDEWEB)

    Ismail, Elna Che; Kaabar, W.; Garrity, D.; Gundogdu, O. [Department of Physics, University of Surrey, Guildford GU2 7XH (United Kingdom); Bunk, O. [Paul Scherrer Institut, CH-5232 Villigen (Switzerland); Pfeiffer, F. [Paul Scherrer Institut, CH-5232 Villigen (Switzerland); Ecole Polytechnique Federale de Lausanne, CH-1015 Lausanne (Switzerland); Farquharson, M.J. [Department of Radiography, City University, London EC1V OHB (United Kingdom); Bradley, D.A. [Department of Physics, University of Surrey, Guildford GU2 7XH (United Kingdom)], E-mail: d.a.bradley@surrey.ac.uk

    2010-04-15

    Synovial joints articulate in a lubricating environment, the system providing for smooth articulation. The articular cartilage overlying the bone consists of a network of collagen fibres. This network is essential to cartilage integrity, suffering damage in degenerative joint disease such as osteoarthritis. At Surrey and also in work conducted by this group at the Paul Scherrer Institute (PSI) synchrotron site we have been applying a number of techniques to study the bone-cartilage interface and of changes occurring in this with disease. One of the techniques attracting particular interest is X-ray phase contrast imaging, yielding information on anatomical features that manifest from the large scale organisation of collagen and the mineralised phase contained within the collagen fibres in the deep cartilage zone. This work briefly reviews some of the basic supporting physics of X-ray phase contrast imaging and then shows example images of the articular surface and subchondral bone and other supporting results obtained to-date. Present results have been obtained on sections of bone not displaying evidence of an osteoarthritic lesion and can be used as a baseline against which diseased bone can be compared.

  20. IPv6 and IPsec Tests of a Space-Based Asset, the Cisco Router in Low Earth Orbit (CLEO)

    Science.gov (United States)

    Ivancic, William; Stewart, David; Wood, Lloyd; Jackson, Chris; Northam, James; Wilhelm, James

    2008-01-01

    This report documents the design of network infrastructure to support testing and demonstrating network-centric operations and command and control of space-based assets, using IPv6 and IPsec. These tests were performed using the Cisco router in Low Earth Orbit (CLEO), an experimental payload onboard the United Kingdom--Disaster Monitoring Constellation (UK-DMC) satellite built and operated by Surrey Satellite Technology Ltd (SSTL). On Thursday, 29 March 2007, NASA Glenn Research Center, Cisco Systems and SSTL performed the first configuration and demonstration of IPsec and IPv6 onboard a satellite in low Earth orbit. IPv6 is the next generation of the Internet Protocol (IP), designed to improve on the popular IPv4 that built the Internet, while IPsec is the protocol used to secure communication across IP networks. This demonstration was made possible in part by NASA s Earth Science Technology Office (ESTO) and shows that new commercial technologies such as mobile networking, IPv6 and IPsec can be used for commercial, military and government space applications. This has direct application to NASA s Vision for Space Exploration. The success of CLEO has paved the way for new spacebased Internet technologies, such as the planned Internet Routing In Space (IRIS) payload at geostationary orbit, which will be a U.S. Department of Defense Joint Capability Technology Demonstration. This is a sanitized report for public distribution. All real addressing has been changed to psueco addressing.

  1. Parents’ Experience and Views of Vaccinating Their Child against Influenza at Primary School and at the General Practice

    Directory of Open Access Journals (Sweden)

    Pauline Paterson

    2018-03-01

    Full Text Available The purpose of this study was to gain an in-depth understanding of parents’ experience and views of vaccinating their four to six-year-old child against influenza at school and at the general practice (GP. A cross-sectional qualitative study was conducted between March–June 2016 with parents of children in Reception and Year 1 in four randomly selected schools in Bury, Leicestershire, and Surrey, England. Twenty-five outreach forms were completed and returned, and seven interviews were conducted. Interview transcripts were coded by theme in NVivo (version 11, QSR International Pty Ltd., Melbourne, Australia. The primary reason parents gave for vaccinating their child was to prevent their child from contracting influenza. Parents’ perceived benefits of vaccinating in schools were to avoid the inconvenience of having to take their child to the GP, and that their child would behave better at school. Parents viewed that accompanying their child for the vaccination at school would undermine the convenience and peer-pressure advantages of the school as a venue. No parents expressed concern about their child being too young to be vaccinated in school. This research suggests that the school is a desirable venue for childhood influenza vaccination, both from the parents’ view and given that influenza vaccination coverage is higher when delivered through schools than GPs.

  2. Parents’ Experience and Views of Vaccinating Their Child against Influenza at Primary School and at the General Practice

    Science.gov (United States)

    Schulz, Will; Larson, Heidi J.

    2018-01-01

    The purpose of this study was to gain an in-depth understanding of parents’ experience and views of vaccinating their four to six-year-old child against influenza at school and at the general practice (GP). A cross-sectional qualitative study was conducted between March–June 2016 with parents of children in Reception and Year 1 in four randomly selected schools in Bury, Leicestershire, and Surrey, England. Twenty-five outreach forms were completed and returned, and seven interviews were conducted. Interview transcripts were coded by theme in NVivo (version 11, QSR International Pty Ltd., Melbourne, Australia). The primary reason parents gave for vaccinating their child was to prevent their child from contracting influenza. Parents’ perceived benefits of vaccinating in schools were to avoid the inconvenience of having to take their child to the GP, and that their child would behave better at school. Parents viewed that accompanying their child for the vaccination at school would undermine the convenience and peer-pressure advantages of the school as a venue. No parents expressed concern about their child being too young to be vaccinated in school. This research suggests that the school is a desirable venue for childhood influenza vaccination, both from the parents’ view and given that influenza vaccination coverage is higher when delivered through schools than GPs. PMID:29597341

  3. Parents' Experience and Views of Vaccinating Their Child against Influenza at Primary School and at the General Practice.

    Science.gov (United States)

    Paterson, Pauline; Schulz, Will; Utley, Martin; Larson, Heidi J

    2018-03-28

    The purpose of this study was to gain an in-depth understanding of parents' experience and views of vaccinating their four to six-year-old child against influenza at school and at the general practice (GP). A cross-sectional qualitative study was conducted between March-June 2016 with parents of children in Reception and Year 1 in four randomly selected schools in Bury, Leicestershire, and Surrey, England. Twenty-five outreach forms were completed and returned, and seven interviews were conducted. Interview transcripts were coded by theme in NVivo (version 11, QSR International Pty Ltd., Melbourne, Australia). The primary reason parents gave for vaccinating their child was to prevent their child from contracting influenza. Parents' perceived benefits of vaccinating in schools were to avoid the inconvenience of having to take their child to the GP, and that their child would behave better at school. Parents viewed that accompanying their child for the vaccination at school would undermine the convenience and peer-pressure advantages of the school as a venue. No parents expressed concern about their child being too young to be vaccinated in school. This research suggests that the school is a desirable venue for childhood influenza vaccination, both from the parents' view and given that influenza vaccination coverage is higher when delivered through schools than GPs.

  4. Astronomers in the Chemist's War

    Science.gov (United States)

    Trimble, Virginia L.

    2012-01-01

    World War II, with radar, rockets, and "atomic" bombs was the physicists' war. And many of us know, or think we know, what our more senior colleagues did during it, with Hubble and Hoffleit at Aberdeen; M. Schwarzschild on active duty in Italy; Bondi, Gold, and Hoyle hunkered down in Dunsfeld, Surrey, talking about radar, and perhaps steady state; Greenstein and Henyey designing all-sky cameras; and many astronomers teaching navigation. World War I was The Chemists' War, featuring poison gases, the need to produce liquid fuels from coal on one side of the English Channel and to replace previously-imported dyesstuffs on the other. The talke will focus on what astronomers did and had done to them between 1914 and 1919, from Freundlich (taken prisoner on an eclipse expedition days after the outbreak of hostilities) to Edwin Hubble, returning from France without ever having quite reached the front lines. Other events bore richer fruit (Hale and the National Research Council), but very few of the stories are happy ones. Most of us have neither first nor second hand memories of The Chemists' War, but I had the pleasure of dining with a former Freundlich student a couple of weeks ago.

  5. Fraser Valley System Reinforcement Project: Environmental planning and assessment report

    International Nuclear Information System (INIS)

    1991-06-01

    Transmission facilities in the south central Fraser Valley, British Columbia, need reinforcement in order to meet anticipated growth in power demand. This objective could be met by reinforcing substation facilities (adding 500-kV equipment and connection to transmission line 5L41) at the McLellan Substation in Surrey, at the Clayburn Substation in Matsqui, or at the Atchelitz Substation in Chilliwack. An assessment is provided of the environmental evaluation criteria applied to these potential sites for substation reinforcement and the rationale for selection of the Clayburn site as the environmentally most effective alternative. The Clayburn site is already cleared and managed for a 230-kV substation; environmental, land use, and socioeconomic impacts are considered manageable. The existing right-of-way for the 500-kV loop in to the substation can be utilized. In addition, the results of an environmental assessment and mitigation plan for the Clayburn substation reinforcement are described. The most significant factors that will require possible mitigative measures include fisheries, water quality, floodplain management, visual and recreational aspects, and heritage resources. 16 figs., 5 tabs

  6. Comparative genomics and drug resistance of a geographic variant of ST239 methicillin-resistant Staphylococcus aureus emerged in Russia.

    Directory of Open Access Journals (Sweden)

    Tatsuo Yamamoto

    Full Text Available Two distinct classes of methicillin-resistant Staphylococcus aureus (MRSA are spreading in hospitals (as hospital-acquired MRSA, HA-MRSA and in the community (as community-acquired MRSA, CA-MRSA. Multilocus sequence type (ST 239 MRSA, one of the most worldwide-disseminated lineages, has been noted as a representative HA-MRSA. Here, we isolated ST239 MRSA (spa type 3 [t037] and staphylococcal cassette chromosome mec [SCCmec] type III.1.1.1 and its novel variant with ST239/spa351 (t030/SCCmecIII.1.1.4 (SCCmecIII(R not only from hospitals but also from patients with urethritis in the community in Russia. The Russian variant (strain 16K possessed a hybrid genome consisting of CC8 and CC30, similar to the ST239/spa3/SCCmecIII.1.1.1 HA-MRSA (TW20 genome, but with marked diversity. The 16K' CC30 section had SCCmecIII(R carrying the dcs-carrying unit (which corresponded to the SCCmecIVc J3 joining region of ST30 CA-MRSA, lacked SCCmercury, and possessed a novel mobile element structure (MES16K carrying the ccrC-carrying unit (with the recombinase gene ccrC1 allele 3 and drug resistance tranposons. The Russian variant included strains with a high ability to transfer its multiple drug resistance by conjugation; e.g., for strain 16K, the transfer frequency of a chloramphenicol resistance plasmid (p16K-1 with 2.9 kb in size reached 1.4×10(-2, followed by Tn554 conjugative transfer at 3.6×l0(-4. The Russian variant, which has been increasing recently, included divergent strains with different plasmid patterns and pulsed field gel electrophoresis profiles. The data demonstrate the alternative nature of ST239 MRSA as CA-MRSA and also as a drug resistance disseminator, and its micro but dynamic evolution in Russia.

  7. Smoking behavior among hospital staff still influences attitudes and counseling on smoking

    DEFF Research Database (Denmark)

    Willaing, Ingrid; Ladelund, Steen

    2004-01-01

    as a risk factor. Nonsmokers might overestimate smoking as a risk factor. Nonsmokers gave patients advice on smoking cessation significantly more often than did current smokers (ex-smokers, OR=2.5, 95% CI=1.8-3.4; never-smokers, OR=1.5, 95% CI=1.1-2.0). Ex-smokers and smokers felt significantly more...... qualified to counsel patients about smoking than did never-smokers (ex-smokers, OR=1.8, 95% CI=1.3-2.5; smokers, OR=1.4, 95% CI=1.0-1.9). Individual smoking behavior among hospital staff was strongly associated with smoking-related knowledge, attitudes, and counseling practices. Lack of self......-related counseling, smoking-related counseling practices, and self-rated qualifications for counseling were main outcome measures. Health professionals who were current smokers systematically underestimated the health consequences of smoking and differed significantly from nonsmokers in their assessments of smoking...

  8. Evaluation of Existing Structures

    Science.gov (United States)

    1974-12-01

    13520 500 G0T0C530.S20*530*5*0). JENTRY 13S30C 135440C INPUT LOAD DATA 133S50 510 PRINT 68(P 13560 READDNPOINT.(TT(J) bPP (J).JO1DNPOINT) 13570 FACTOR*1.O...T’)IST(CCI’d0E4,5)𔃿) 710p0 ?J.A41-ý4E5T04eS"RTDIST TCl’J0)E-1b)/5) 71 0:0 Snl=S/l(S0Sf)T( CH 4 75( C 1 I0Ex- 15 /5)) 71040 Pl0-t~ fFA ’-1.2q32*SD 710

  9. Perceptions, work environment, and job stress related with tobacco use among fishermen in remote Island, Rebun Japan

    Directory of Open Access Journals (Sweden)

    Eri Kanazawa

    2018-03-01

    Independent t-test at 95% confidence. Results The result showed 45.3% were current smokers (43.4% daily smoker, and 1.9% occasional smoker, and 54.7% (33.0% ex-smoker and 21.7% never smoker were non-smokers. Age(r=0.070, marital status(r=0.002, present of smoker in family(r=0.030, having chronic diseases(r=0.001, job experience(r=0.002, perceptions (perceived susceptibility(r=0.033, perceived benefits(r=0.049, and perceived barriers(r< 0.001 showed strong association with smoking behavior among fishermen in Rebun Island. Conclusions Health promotion program for fishermen is necessary in order to educate them for raising perception toward smoking and for understanding the importance of smoking cessation among fishermen in Rebun Island.

  10. The carbon emissions generated in all that we consume

    International Nuclear Information System (INIS)

    2006-01-01

    The aim of the study was to increase the understanding of the fundamental drivers of carbon emissions in the UK and to show how all carbon emissions can be attributed to the delivery of products and services to meet the needs of the end consumer. From this work, it is possible to identify the products and services which have the highest carbon emissions associated with their supply chains. The study was undertaken on behalf of the Carbon Trust by the Centre for Environmental Strategy at the University of Surrey and Enviros Consulting. The analysis was based on an economic model developed at the University of Surrey, which analysed the UK's carbon emissions in terms of the total carbon embodied in consumer products and services. The results of the analysis can be cast in a variety of ways depending on the classifications used. The study starts with an analysis of the traditional production perspective and then reclassifies carbon emissions into consumption categories before combining those categories into high-level consumer needs categories. This analysis leads to the following general conclusions: From the traditional production perspective: The Electricity Production category has the highest emissions at almost 24 MtC (millions tonnes carbon per annum); The Other Land Transport category (comprising road freight, buses and coaches, taxis etc.) and the Refining Industries category have second and third highest emissions at 7.9 MtC and 7.1 MtC respectively; and The categories relating to the provision of final products and services to the consumer all have emissions of less than 2 MtC. This perspective shows total emissions of 88.1 MtC. It excludes aviation fuel emissions (11.0 MtC), domestic electricity (22.0 MtC), domestic fuel use (25.3 MtC), domestic private transport fuel use (18.3 MtC) and the UK carbon trade balance (11.7 MtC), totalling 88.3 MtC. The emissions can then be reallocated from this traditional production perspective to different consumption

  11. Small Satellites and the Nigerian National Space Programme

    Science.gov (United States)

    Borroffice, Robert; Chizea, Francis; Sun, Wei; Sweeting, Martin, , Sir

    2002-01-01

    Space technology and access to space have been elusive to most developing countries over the last half of the 21st century, which is attributed to very low par capital income and the lack of awareness of policy/decision makers about the role of space technology in national development. Space technology was seen as very expensive and prestigious, meant only for the major industrialized countries, while the developing countries should focus on building their national economy and providing food, shelter and other social amenities for their ever-growing populations. In the last decade, the trend has changed with many developing countries embracing spaced technology as one of the major ways of achieving sustainable development. The present trend towards the use of small satellites in meeting national needs has aided this transition because, apart from the small size, they are cheaper to build and to launch, with shorter development time, lower complexity, improved effectiveness and reduced operating costs. This in turn has made them more affordable and has opened up new avenues for the acquisition of satellite technology. The collaborative work between National Space Research and Development Agency of Nigeria (NASRDA) and Surrey Satellite and Technology Limited (SSTL) is a programme aimed at building two small satellites as a way of kick- starting the national space programme. The first project, NigeriaSAT-1, is an enhanced microsatellite carrying Earth observation payloads able to provide 32 metre GSD 3 band multispectral images with a 600km swath width. NigeriaSAT-1 is one of six microsatellites forming the Disaster Monitoring Constellation (DMC) alongside microsatellites contributed by Algeria, China, Turkey, Thailand and UK. Through participation in this international constellation, Nigeria will be able to receive images with a daily revisit worldwide. The EO images generated by NigeriaSAT-1 and the partner microsatellites will be used for providing rapid coverage

  12. Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics

    Directory of Open Access Journals (Sweden)

    Wacheck V

    2011-05-01

    Full Text Available Volker Wacheck1, Michael Lahn2, Gemma Dickinson3, Wolfgang Füreder4, Renata Meyer4, Susanne Herndlhofer4, Thorsten Füreder1, Georg Dorfner5, Sada Pillay2, Valérie André6, Timothy P Burkholder7, Jacqueline K Akunda8, Leann Flye-Blakemore9, Dirk Van Bockstaele9, Richard F Schlenk10, Wolfgang R Sperr4, Peter Valent4,111Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel, Vienna, Austria; 2Early Oncology Clinical Investigation, Eli Lilly and Company, Indianapolis, IN, USA; 3Department of Pharmacokinetics, Eli Lilly and Company, Erl Wood Research Centre, Windlesham, Surrey, UK; 4Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Währinger Gürtel, Vienna, Austria; 5Eli Lilly GesmbH, Medical Department, Vienna, Austria; 6Department of Statistics, Eli Lilly and Company, Erl Wood Research Centre, Surrey, UK; 7Discovery Chemistry Research and Technology, Eli Lilly and Company, Indianapolis, IN, USA; 8Nonclinical Toxicology, Eli Lilly and Company, Indianapolis, IN, USA; 9Flow Cytometry and Cell Analysis, Esoterix Clinical Trials Services, Mechelen, Belgium; 10Universitätsklinikum Ulm, Klinik für Innere Medizin III, Ulm, Germany; 11Ludwig Boltzmann Cluster Oncology, Vienna, AustriaBackground: Acute myeloid leukemia (AML is a life-threatening malignancy with limited treatment options in chemotherapy-refractory patients. A first-in-human dose study was designed to investigate a safe and biologically effective dose range for LY2457546, a novel multikinase inhibitor, in patients with relapsed AML.Methods: In this nonrandomized, open-label, dose escalation Phase I study, LY2457546 was administered orally once a day. Safety, pharmacokinetics, changes in phosphorylation of target kinases in AML blasts, and risk of drug–drug interactions (DDI were assessed.Results: Five patients were treated at the starting and predicted minimal biologically effective dose of 50 mg

  13. Jumping to conclusions in schizophrenia

    Directory of Open Access Journals (Sweden)

    Evans SL

    2015-07-01

    Full Text Available Simon L Evans,1 Bruno B Averbeck,2 Nicholas Furl31School of Psychology, University of Sussex, Brighton, East Sussex, UK; 2Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA; 3Department of Psychology, Royal Holloway, University of London, Egham, Surrey, UKAbstract: Schizophrenia is a mental disorder associated with a variety of symptoms, including hallucinations, delusions, social withdrawal, and cognitive dysfunction. Impairments on decision-making tasks are routinely reported: evidence points to a particular deficit in learning from and revising behavior following feedback. In addition, patients tend to make hasty decisions when probabilistic judgments are required. This is known as “jumping to conclusions” (JTC and has typically been demonstrated by presenting participants with colored beads drawn from one of two “urns” until they claim to be sure which urn the beads are being drawn from (the proportions of colors vary in each urn. Patients tend to make early decisions on this task, and there is evidence to suggest that a hasty decision-making style might be linked to delusion formation and thus be of clinical relevance. Various accounts have been proposed regarding what underlies this behavior. In this review, we briefly introduce the disorder and the decision-making deficits associated with it. We then explore the evidence for each account of JTC in the context of a wider decision-making deficit and then go on to summarize work exploring JTC in healthy controls using pharmacological manipulations and functional imaging. Finally, we assess whether JTC might have a role in therapy.Keywords: ketamine, decision making, delusions, fMRI, urn task

  14. An analysis of the low-earth-orbit communications environment

    Science.gov (United States)

    Diersing, Robert Joseph

    Advances in microprocessor technology and availability of launch opportunities have caused interest in low-earth-orbit satellite based communications systems to increase dramatically during the past several years. In this research the capabilities of two low-cost, store-and-forward LEO communications satellites operating in the public domain are examined--PACSAT-1 (operated by the Radio Amateur Satellite Corporation) and UoSAT-3 (operated by the University of Surrey, England, Electrical Engineering Department). The file broadcasting and file transfer facilities are examined in detail and a simulation model of the downlink traffic pattern is developed. The simulator will aid the assessment of changes in design and implementation for other systems. The development of the downlink traffic simulator is based on three major parts. First, is a characterization of the low-earth-orbit operating environment along with preliminary measurements of the PACSAT-1 and UoSAT-3 systems including: satellite visibility constraints on communications, monitoring equipment configuration, link margin computations, determination of block and bit error rates, and establishing typical data capture rates for ground stations using computer-pointed directional antennas and fixed omni-directional antennas. Second, arrival rates for successful and unsuccessful file server connections are established along with transaction service times. Downlink traffic has been further characterized by measuring: frame and byte counts for all data-link layer traffic; 30-second interval average response time for all traffic and for file server traffic only; file server response time on a per-connection basis; and retry rates for information and supervisory frames. Finally, the model is verified by comparison with measurements of actual traffic not previously used in the model building process. The simulator is then used to predict operation of the PACSAT-1 satellite with modifications to the original design.

  15. Perceived causes of differential attainment in UK postgraduate medical training: a national qualitative study.

    Science.gov (United States)

    Woolf, Katherine; Rich, Antonia; Viney, Rowena; Needleman, Sarah; Griffin, Ann

    2016-11-25

    Explore trainee doctors' experiences of postgraduate training and perceptions of fairness in relation to ethnicity and country of primary medical qualification. Qualitative semistructured focus group and interview study. Postgraduate training in England (London, Yorkshire and Humber, Kent Surrey and Sussex) and Wales. 137 participants (96 trainees, 41 trainers) were purposively sampled from a framework comprising: doctors from all stages of training in general practice, medicine, obstetrics and gynaecology, psychiatry, radiology, surgery or foundation, in 4 geographical areas, from white and black and minority ethnic (BME) backgrounds, who qualified in the UK and abroad. Most trainees described difficult experiences, but BME UK graduates (UKGs) and international medical graduates (IMGs) could face additional difficulties that affected their learning and performance. Relationships with senior doctors were crucial to learning but bias was perceived to make these relationships more problematic for BME UKGs and IMGs. IMGs also had to deal with cultural differences and lack of trust from seniors, often looking to IMG peers for support instead. Workplace-based assessment and recruitment were considered vulnerable to bias whereas examinations were typically considered more rigorous. In a system where success in recruitment and assessments determines where in the country you can get a job, and where work-life balance is often poor, UK BME and international graduates in our sample were more likely to face separation from family and support outside of work, and reported more stress, anxiety or burnout that hindered their learning and performance. A culture in which difficulties are a sign of weakness made seeking support and additional training stigmatising. BME UKGs and IMGs can face additional difficulties in training which may impede learning and performance. Non-stigmatising interventions should focus on trainee-trainer relationships at work and organisational changes to

  16. ¿Ellos y Nosotros o Ellos v/s Nosotros?: Reporte de una Experiencia de Fusión en el Ámbito Educacional ¿They & Us or They v/s Us?: Report of an Educational Merging Project

    Directory of Open Access Journals (Sweden)

    Antonella Moure

    2004-05-01

    Full Text Available La motivación central de este trabajo es examinar una experiencia de fusión escolar. Se reporta la experiencia de fusión realizada por un colegio particular de Santiago de Chile. Para ello, se llevó a cabo un estudio de carácter cualitativo y cuantitativo, mediante la realización de entrevistas en profundidad y la aplicación de una encuesta post-hoc. Se examina la escuela como una empresa educacional, desde donde es posible entender la importancia de la fusión entre dos establecimientos, cuyo objetivo es aumentar el desempeño educativo, logrando ventajas con los recursos que se posee. Si bien la fusión de culturas puede darse exitosamente, es un proceso largo, no exento de dificultades y en el cual se requieren ciertas condiciones para lograrla.The main purpose of this work is to report the outcome of an educational merging project. The study was conducted in a private school in Santiago, Chile that is implementing this change. A detailed assessment was performed by in-depth interviews with the involved parties and evaluations through a surrey at the end of the experience. The school is seen in the light of an educational enterprise, whose main goals are to improve students' performance by obtaining maximum advantage of its' resources. We conclude that intercultural education can succeed as a long term process, despite the need for certain initial conditions and implementation difficulties.

  17. NET-COMPUTER: Internet Computer Architecture and its Application in E-Commerce

    Directory of Open Access Journals (Sweden)

    P. O. Umenne

    2012-12-01

    Full Text Available Research in Intelligent Agents has yielded interesting results, some of which have been translated into commer­cial ventures. Intelligent Agents are executable software components that represent the user, perform tasks on behalf of the user and when the task terminates, the Agents send the result to the user. Intelligent Agents are best suited for the Internet: a collection of computers connected together in a world-wide computer network. Swarm and HYDRA computer architectures for Agents’ execution were developed at the University of Surrey, UK in the 90s. The objective of the research was to develop a software-based computer architecture on which Agents execution could be explored. The combination of Intelligent Agents and HYDRA computer architecture gave rise to a new computer concept: the NET-Computer in which the comput­ing resources reside on the Internet. The Internet computers form the hardware and software resources, and the user is provided with a simple interface to access the Internet and run user tasks. The Agents autonomously roam the Internet (NET-Computer executing the tasks. A growing segment of the Internet is E-Commerce for online shopping for products and services. The Internet computing resources provide a marketplace for product suppliers and consumers alike. Consumers are looking for suppliers selling products and services, while suppliers are looking for buyers. Searching the vast amount of information available on the Internet causes a great deal of problems for both consumers and suppliers. Intelligent Agents executing on the NET-Computer can surf through the Internet and select specific information of interest to the user. The simulation results show that Intelligent Agents executing HYDRA computer architecture could be applied in E-Commerce.

  18. Educational challenges faced by international medical graduates in the UK

    Directory of Open Access Journals (Sweden)

    Hashim A

    2017-06-01

    Full Text Available Ahmed Hashim Gastroenterology Department, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK Introduction: International medical graduates (IMGs in the UK constitute approximately one-quarter of the total number of doctors registered in the General Medical Council (GMC. The transition of IMGs into the health care system in the UK is accompanied by significant sociocultural and educational challenges. This study aims to explore the views of IMGs in medical training on the educational challenges they face.Methods: This study was conducted in the Kent, Surrey and Sussex region in 2015. All IMGs who work in medical (physicianly training programs were included. Data were collected through a questionnaire and semi-structured interviews. Thematic approach was used to analyze the qualitative data.Results: Of the total 61 IMGs included, 17 responded to the survey and 3 were interviewed. The common educational barriers faced by IMGs were related to lack of appreciation of the values and structure of the National Health Service (NHS, ethical and medicolegal issues, receiving feedback from colleagues and the different learning strategies in the UK. IMGs suggested introduction of a mandatory dedicated induction program in the form of formal teaching sessions. They also believed that a supervised shadowing period prior in the first job in the UK would be beneficial. Further assessment areas should be incorporated into the prequalifying examinations to address specific educational needs such as NHS structure and hospital policies. Other measures such as buddying schemes with senior IMGs and educating NHS staff on different needs of IMGs should also be considered.Conclusion: This study highlighted important educational challenges faced by IMGs and generated relevant solutions. However, the opinions of the supervisors and other health care professionals need to be explored. Keywords: international medical graduates, IMG, educational barriers

  19. LNG demand, shipping will expand through 2010

    International Nuclear Information System (INIS)

    True, W.R.

    1998-01-01

    The 1990s, especially the middle years, have witnessed a dramatic turnaround in the growth of liquefied-natural-gas demand which has tracked equally strong natural-gas demand growth. This trend was underscored late last year by several annual studies of world LNG demand and shipping. As 1998 began, however, economic turmoil in Asian financial markets has clouded near-term prospects for LNG in particular and all energy in general. But the extent of damage to energy markets is so far unclear. A study by US-based Institute of Gas Technology, Des Plaines, IL, reveals that LNG imports worldwide have climbed nearly 8%/year since 1980 and account for 25% of all natural gas traded internationally. In the mid-1970s, the share was only 5%. In 1996, the most recent year for which complete data are available, world LNG trade rose 7.7% to a record 92 billion cu m, outpacing the overall consumption for natural gas which increased 4.7% in 1996. By 2015, says the IGT study, natural-gas use would surpass coal as the world''s second most widely used fuel, after petroleum. Much of this growth will occur in the developing countries of Asia where gas use, before the current economic crisis began, was projected to grow 8%/year through 2015. Similar trends are reflected in another study of LNG trade released at year end 1997, this from Ocean Shipping Consultants Ltd., Surrey, U.K. The study was done too early, however, to consider the effects of the financial problems roiling Asia

  20. Differences in adolescents' physical activity from school-travel between urban and suburban neighbourhoods in Metro Vancouver, Canada.

    Science.gov (United States)

    Frazer, Amanda; Voss, Christine; Winters, Meghan; Naylor, Patti-Jean; Higgins, Joan Wharf; McKay, Heather

    2015-01-01

    To investigate differences in moderate-to-vigorous physical activity (MVPA) from school-travel between adolescents in urban and suburban neighbourhoods and to describe its relative contribution to MVPA on school days. We measured 243 adolescents (51% male, grades 8-10) from Vancouver's walkable downtown core and its largely car-dependent suburb Surrey (fall 2011, 2013). We estimated mean school-travel MVPA from accelerometry (hour before/after school on ≥ 2 days; n = 110, 39% male) and compared school-travel MVPA by neighbourhood type and school-travel mode. The influence of mean school-travel MVPA on mean school-day MVPA (≥ 600 min valid wear time on ≥ 2 days) was examined by linear regression. Over half of students used active modes (urban: 63%, suburban: 53%). Those using active travel and living in the urban neighbourhood obtained the most school-travel MVPA (22.3 ± 8.0 min). Urban passive travellers used public transit and obtained more school-travel MVPA than suburban students (16.9 ± 6.2 vs. 8.0 ± 5.3, p travel MVPA (R (2) = 0.38, p travel MVPA in adolescents. School-travel MVPA is an important contributor to adolescents' school-day MVPA. Where feasible, physically active options for school-travel should be promoted, including public transit.

  1. Contrast-Enhanced Ultrasonography of Hepatocellular Carcinoma After Chemoembolisation Using Drug-Eluting Beads: A Pilot Study Focused on Sustained Tumor Necrosis

    International Nuclear Information System (INIS)

    Moschouris, Hippocrates; Malagari, Katerina; Papadaki, Marina Georgiou; Kornezos, Ioannis; Matsaidonis, Dimitrios

    2010-01-01

    The purpose of this study was to assess the use of contrast-enhanced ultrasonography (CEUS) and the sustained antitumor effect of drug-eluting beads used for transarterial chemoembolisation (TACE) of unresectable hepatocellular carcinoma (HCC). Ten patients with solitary, unresectable HCC underwent CEUS before, 2 days after, and 35 to 40 days after TACE using a standard dose (4 ml) of drug-eluting beads (DC Beads; Biocompatibles, Surrey, UK) preloaded with doxorubicin (25 mg doxorubicin/ml hydrated beads). For CEUS, a second-generation contrast agent (SonoVue, Bracco, Milan, Italy) and a low mechanical-index technique were used. A part of the tumor was characterized as necrotic if it showed complete lack of enhancement. The percentage of necrosis was calculated at the sonographic section that depicted the largest diameter of the tumor. Differences in the extent of early (2 days after TACE) and delayed (35 to 40 days after TACE) necrosis were quantitatively and subjectively assessed. Early post-TACE tumor necrosis ranged from 21% to 70% (mean 43.5% ± 19%). There was a statistically significant (p = 0.0012, paired Student t test) higher percentage of delayed tumor necrosis, which ranged from 24% to 88% (mean 52.3% ± 20.3%). Subjective evaluation showed a delayed obvious increase of the necrotic areas in 5 patients. In 2 patients, tumor vessels that initially remained patent disappeared on the delayed follow-up. A part of tumor necrosis after chemoembolisation of HCC with DEB seems to take place later than 2 days after TACE. CEUS may provide evidence for the sustained antitumor effect of DEB-TACE. Nevertheless, the ideal time for the imaging evaluation of tumor response remains to be defined.

  2. The strengthening of embrittled books using gamma radiation

    International Nuclear Information System (INIS)

    Egan, A.; Mardian, J.; Foot, M.; King, E.; Millington, A.; Nevin, M.; Butler, C.; Barker, J.; Fletcher, D.

    1995-01-01

    The embrittlement of papers, manufactured through processes introduced in the mid-19th century, has caused many millions of books to become fragile, even to the point of being unusable. During the 1980s the British Library funded a research programme, carried out at the University of Surrey, to develop a technology which could be used to treat brittle books on a large scale, with the goal of greatly extending their useful life. The process developed, known as graft co-polymerization, involves three stages: i) application of a cocktail of monomers to the book's pages; ii) equilibration of these monomers throughout the text block; and iii) a low, slow dose of γ-radiation to effect polymerization. In collaboration with the British Library, Nordion International has designed a full-scale book-strengthening plant capable of processing between 200,000 and 500,000 and 500,000 books per year, with estimated prices to customers in the region of 1 8-10 per volume (US $12-16). In order to test the equipment and procedures that would be involved in such a plant, pilot-scale equipment has been designed and assembled on the premises of Isotron plc, where use is made of a conventional irradiator. This paper gives details of the graft co-polymerization process, and some results of the pilot-scale work, in terms of both efficacy and controllability. It also discusses the technical and economic feasibility of building and running a full-scale plant. (author)

  3. Investigating the influence of African American and African Caribbean race on primary care doctors' decision making about depression.

    Science.gov (United States)

    Adams, A; Vail, L; Buckingham, C D; Kidd, J; Weich, S; Roter, D

    2014-09-01

    This paper explores differences in how primary care doctors process the clinical presentation of depression by African American and African-Caribbean patients compared with white patients in the US and the UK. The aim is to gain a better understanding of possible pathways by which racial disparities arise in depression care. One hundred and eight doctors described their thought processes after viewing video recorded simulated patients presenting with identical symptoms strongly suggestive of depression. These descriptions were analysed using the CliniClass system, which captures information about micro-components of clinical decision making and permits a systematic, structured and detailed analysis of how doctors arrive at diagnostic, intervention and management decisions. Video recordings of actors portraying black (both African American and African-Caribbean) and white (both White American and White British) male and female patients (aged 55 years and 75 years) were presented to doctors randomly selected from the Massachusetts Medical Society list and from Surrey/South West London and West Midlands National Health Service lists, stratified by country (US v.UK), gender, and years of clinical experience (less v. very experienced). Findings demonstrated little evidence of bias affecting doctors' decision making processes, with the exception of less attention being paid to the potential outcomes associated with different treatment options for African American compared with White American patients in the US. Instead, findings suggest greater clinical uncertainty in diagnosing depression amongst black compared with white patients, particularly in the UK. This was evident in more potential diagnoses. There was also a tendency for doctors in both countries to focus more on black patients' physical rather than psychological symptoms and to identify endocrine problems, most often diabetes, as a presenting complaint for them. This suggests that doctors in both countries

  4. BREAD CRUMBS TEXTURE OF SPELT

    Directory of Open Access Journals (Sweden)

    Joanna Korczyk – Szabó

    2014-02-01

    Full Text Available Texture analysis is an objective physical examination of baked products and gives direct information on the product quality, oppositely to dough rheology tests what inform on the baking suitability of the flour, as raw material. Evaluation of the mechanical properties of bread crumb is important not only for quality assurance in the bakeries, but also for assessing the effects of changes in dough ingredients and processing condition and also for describing the changes in bread crumb during storage. Crumb cellular structure is an important quality criterion used in commercial baking and research laboratories to judge bread quality alongside taste, crumb colour and crumb physical texture. In the framework of our research during the years 2010 – 2011 were analyzed selected indicators of bread crumb for texture quality of three Triticum spelta L. cultivars – Altgold, Rubiota and Ostro grown in an ecological system. The bread texture quality was evaluated on texture analyzer TA.XT Plus (Stable Micro Systems, Surrey, UK, following the AACC (74-09 standard and expressed as crumb firmness (N, stiffness (N.mm-1 and relative elasticity (%. Our research proved that all selected indicators were significantly influenced by the year of growing and variety. The most soft bread was achieved in Rubiota, whereas bread crumb samples from Altgold and Ostro were the most firm and stiff. Correlation analysis showed strong negative correlation between relative elasticity and bread crumb firmness as well as bread stiffness (-0.65++, -0.66++. The spelt wheat bread crumb texture need further investigation as it can be a reliable quality parameter.

  5. The influence of social psychological factors on behaviour, stress and dose in Chernobyl affected areas

    International Nuclear Information System (INIS)

    Murphy, M.; Allen, P.

    1998-01-01

    During the 12 years since the Chernobyl nuclear accident, people in the affected areas have lived day to day with the risks of radiation. During these 12 years many countermeasures have been applied to minimise dose and thus reduce the threat to the health of the affected populations. Some of these countermeasures are aimed at changing daily life; for example, advice and restrictions on behaviours relating to the forest, consumption of forest produce and the consumption of private milk. In order to be effective, these countermeasures require action, or compliance, on the part of the affected populations. How have people in these areas responded to this risk and to the countermeasures employed to minimise the risk? A number of social psychological factors may be involved in peoples responses to this situation, including their perceptions of threat, the perceived costs and benefits of the behaviours involved, and the influence of other people. We examine the influence of these various social psychological factors on compliance behaviour, dose, and stress related health through a survey of people in the affected areas using quantitative questionnaire measures. SPARPA or Social psychological aspects of radiation protection after accidents, is a European Commission-sponsored project (F14C-CT96-0010) involving U. Surrey, Symlog and NRPB as well as partners in the CIS. Specific objectives include: to characterise, using quantitative methods, the nature and psychological impact of countermeasures and the influence of behaviour on dose, and to develop, guidance on the implementation of countermeasures, taking account of the social and psychological context. (authors)

  6. Bilimsel Toplantı Duyuruları

    Directory of Open Access Journals (Sweden)

    Adli Tıp Uzmanları Derneği ATUD

    2006-08-01

    Full Text Available AAFS 59th Annual Scientific Meeting 19-24 February 2007, USA Further information: San Antonio, TX. Tel: (250 426-7282 Web: www.asfo.org SAFCON-2007 South Asian And VII Annual National Conference Of Indian Congress Of Forensic Medicine & Toxicology 24-25 March 2007, India Further information: E-mail: safcon2007@forensicindia.com Web: www.icfmt.org SCANNING 2007 “Scanning Microscopy In Forensics Science” 10-12 April 2007 CA,USA Further information S. Frank Platek, Forensic Chemistry Center, US Food and Drug Administration, 6751 Steger Drive, Cincinnati, OH Tel: 513-679-2700 x254 Email: fplatek@ora.fda.gov Web: www.fams.org The 9th Annual Conference of BAHID 12-14 April 2007, United Kingdom University of Surrey, Guildford Further information: Web:www.bahid.org AFDIL’s International Training Course 16-20 April 2007, USA Extraction of DNA from Aged Skeletal Remains and Forensic Mitochondrial DNA Sequence Further information: The Armed Forces DNA Identification Laboratory, 1413 Research Blvd, Bldg, 101, Rockville, MD 20850 25th Annual CME Symposium in Forensic Psychiatry April 26-29, 2007 Santa Fe, New Mexico - Inn and Spa at Loretto Further information : American College of Forensic Psychiatry PO Box 5870, Balboa Island CA 92662 Tel: (949 673-7773 www.forensicpsychonline.com VII.Adli Bilimler Sempozyumu Çocuk İstismarı ve İhmaline Güncel Yaklaşımlar 24-27 Mayıs 2007, Gaziantep İletişim: Dr.Aysun BARANSEL ISIR Gaziantep Üniversitesi Tıp Fakültesi Adli Tıp A.D. Tel: 0 342 360 60 60 / 76181 E-posta: aybaransel@yahoo.com Web: www.atud.org

  7. Text messaging reminders for influenza vaccine in primary care: protocol for a cluster randomised controlled trial (TXT4FLUJAB).

    Science.gov (United States)

    Herrett, Emily; van Staa, Tjeerd; Free, Caroline; Smeeth, Liam

    2014-05-02

    The UK government recommends that at least 75% of people aged under 64 with certain conditions receive an annual influenza vaccination. Primary care practices often fall short of this target and strategies to increase vaccine uptake are required. Text messaging reminders are already used in 30% of practices to remind patients about vaccination, but there has been no trial addressing their effectiveness in increasing influenza vaccine uptake in the UK. The aims of the study are (1) to develop the methodology for conducting cluster randomised trials of text messaging interventions utilising routine electronic health records and (2) to assess the effectiveness of using a text messaging influenza vaccine reminder in achieving an increase in influenza vaccine uptake in patients aged 18-64 with chronic conditions, compared with standard care. This cluster randomised trial will recruit general practices across three settings in English primary care (Clinical Practice Research Datalink, ResearchOne and London iPLATO text messaging software users) and randomise them to either standard care or a text messaging campaign to eligible patients. Flu vaccine uptake will be ascertained using routinely collected, anonymised electronic patient records. This protocol outlines the proposed study design and analysis methods. This study will determine the effectiveness of text messaging vaccine reminders in primary care in increasing influenza vaccine uptake, and will strengthen the methodology for using electronic health records in cluster randomised trials of text messaging interventions. This trial was approved by the Surrey Borders Ethics Committee (13/LO/0872). The trial results will be disseminated at national conferences and published in a peer-reviewed medical journal. The results will also be distributed to the Primary Care Research Network and to all participating general practices. This study is registered at controlled-trials.com ISRCTN48840025, July 2013.

  8. Helicopter emergency medical services response to equestrian accidents.

    Science.gov (United States)

    Lyon, Richard M; Macauley, Ben; Richardson, Sarah; de Coverly, Richard; Russell, Malcolm

    2015-04-01

    Horse riding is a common leisure activity associated with a significant rate of injury. Helicopter emergency medical services (HEMS) may be called to equestrian accidents. Accurate HEMS tasking is important to ensure appropriate use of this valuable medical resource. We sought to review HEMS response to equestrian accidents and identify factors associated with the need for HEMS intervention or transport of the patient to a major trauma centre. Retrospective case review of all missions flown by Kent, Surrey & Sussex Air Ambulance Trust over a 1-year period (1 July 2011 to 1 July 2012). All missions were screened for accidents involving a horse. Call details, patient demographics, suspected injuries, clinical interventions and patient disposition were all analysed. In the 12-month data collection period there were 47 equestrian accidents, representing ∼3% of the total annual missions. Of the 42 cases HEMS attended, one patient was pronounced life extinct at the scene. In 15 (36%) cases the patient was airlifted to hospital. In four (10%) cases, the patient underwent prehospital anaesthesia. There were no specific predictors of HEMS intervention. Admission to a major trauma centre was associated with the rider not wearing a helmet, a fall onto their head or the horse falling onto the rider. Equestrian accidents represent a significant proportion of HEMS missions. The majority of patients injured in equestrian accidents do not require HEMS intervention, however, a small proportion have life-threatening injuries, requiring immediate critical intervention. Further research is warranted, particularly regarding HEMS dispatch, to further improve accuracy of tasking to equestrian accidents.

  9. Remote Sensing of Martian Terrain Hazards via Visually Salient Feature Detection

    Science.gov (United States)

    Al-Milli, S.; Shaukat, A.; Spiteri, C.; Gao, Y.

    2014-04-01

    The main objective of the FASTER remote sensing system is the detection of rocks on planetary surfaces by employing models that can efficiently characterise rocks in terms of semantic descriptions. The proposed technique abates some of the algorithmic limitations of existing methods with no training requirements, lower computational complexity and greater robustness towards visual tracking applications over long-distance planetary terrains. Visual saliency models inspired from biological systems help to identify important regions (such as rocks) in the visual scene. Surface rocks are therefore completely described in terms of their local or global conspicuity pop-out characteristics. These local and global pop-out cues are (but not limited to); colour, depth, orientation, curvature, size, luminance intensity, shape, topology etc. The currently applied methods follow a purely bottom-up strategy of visual attention for selection of conspicuous regions in the visual scene without any topdown control. Furthermore the choice of models used (tested and evaluated) are relatively fast among the state-of-the-art and have very low computational load. Quantitative evaluation of these state-ofthe- art models was carried out using benchmark datasets including the Surrey Space Centre Lab Testbed, Pangu generated images, RAL Space SEEKER and CNES Mars Yard datasets. The analysis indicates that models based on visually salient information in the frequency domain (SRA, SDSR, PQFT) are the best performing ones for detecting rocks in an extra-terrestrial setting. In particular the SRA model seems to be the most optimum of the lot especially that it requires the least computational time while keeping errors competitively low. The salient objects extracted using these models can then be merged with the Digital Elevation Models (DEMs) generated from the same navigation cameras in order to be fused to the navigation map thus giving a clear indication of the rock locations.

  10. Recovery in patients with major depressive disorder (MDD: results of a 6-month, multinational, observational study

    Directory of Open Access Journals (Sweden)

    Novick D

    2017-10-01

    Full Text Available Diego Novick,1 William Montgomery,2 Ellen Vorstenbosch,3 Maria Victoria Moneta,3 Héctor Dueñas,4 Josep Maria Haro3 1Eli Lilly and Company, Windlesham, Surrey, UK; 2Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 3Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain; 4Eli Lilly de Mexico, Mexico City, Mexico Abstract: Not all individuals treated for major depressive disorder (MDD achieve recovery. This observational study examined the recovery rates in MDD patients and the patient characteristics associated with achieving recovery in a naturalistic clinical setting. Recovery was defined as having both clinical and functional remission. Data for this post hoc analysis were taken from a 24-week prospective, observational study that involved 1,549 MDD patients. Clinical remission was assessed using the 16-item Quick Inventory of Depressive Symptomatology Self-Report and functional remission through the Sheehan Disability Scale and no days of reduced productivity in the previous week. Generalized estimating equation regression models were used to examine the baseline factors associated with recovery during follow-up. Clinical and functional remission was achieved in 70.6% and 56.1% of the MDD patients, respectively. MDD patients who achieved recovery (52.1% were significantly less likely to have impaired levels of functioning, concurrent medical or psychiatric conditions, low levels of education, or nonadherence to therapy at follow-up. The level of functioning during the index episode seems to be a better predictor of recovery than symptom severity. Therefore, the level of functioning should be considered while determining recovery from depression. Keywords: remission, functional impairment, clinical remission, course of illness, disability, predictors

  11. "Testing is Healthy" TimePlay campaign: Evaluation of sexual health promotion gamification intervention targeting young adults.

    Science.gov (United States)

    Zhang, Qinya; Huhn, Kim J; Tan, Andy; Douglas, Rachel E; Li, Helen Guiyun; Murti, Michelle; Lee, Victoria

    2017-04-20

    The objectives of the study were to 1) describe the implementation of the "Testing is Healthy" campaign in four locations in British Columbia (BC) and 2) report process evaluation indicators for the campaign. Young adults ages 20-29 years, the age group with the highest reported rates of chlamydia and gonorrhea in BC. Movie theatres located in Langley, Burnaby, Coquitlam and Surrey, which are communities served by the Fraser Health Authority (FHA) in BC. The FHA launched the campaign in 2014 and 2015 to bring down the prevalence of sexually transmitted infections (STIs) and HIV in the region. The campaign used the Cineplex TimePlay platform to engage moviegoers in answering STI/HIV-related questions, and to connect them to a clinic finder on the BC Centre for Disease Control Sex Smart Resource (SSR) website. TimePlay includes elements of gaming, is technology-based, and has been a successful advertisement platform for consumer products and services. However, this is the first time it has been used for sexual health promotion. The campaign was evaluated for 1) reach, based on theatre attendance and TimePlay participation, and 2) the effectiveness of connecting people to sexual health information using SSR web analytics. In total, the campaign received 548 410 views and 77 149 plays. SSR web analytics showed a significant increase in unique page views of the Clinic Finder page between the first and the second campaign. The campaign reached a large population at a low cost and was correlated with spikes in the unique page views for the Clinic Finder page.

  12. Encouraging formative assessments of leadership for foundation doctors.

    Science.gov (United States)

    Hadley, Lindsay; Black, David; Welch, Jan; Reynolds, Peter; Penlington, Clare

    2015-08-01

    Clinical leadership is considered essential for maintaining and improving patient care and safety in the UK, and is incorporated in the curriculum for all trainee doctors. Despite the growing focus on the importance of leadership, and the introduction of the Medical Leadership Competency Framework (MLCF) in the UK, leadership education for doctors in training is still in its infancy. Assessment is focused on clinical skills, and trainee doctors receive very little formal feedback on their leadership competencies. In this article we describe the approach taken by Health Education Kent, Sussex and Surrey (HEKSS) to raise the profile of leadership amongst doctors in training in the South Thames Foundation School (STFS). An annual structured formative assessment in leadership for each trainee has been introduced, supported by leadership education for both trainees and their supervisors in HEKSS trusts. We analysed over 500 of these assessments from the academic year 2012/13 for foundation doctors in HEKSS trusts, in order to assess the quality of the feedback. From the analysis, potential indicators of more effective formative assessments were identified. These may be helpful in improving the leadership education programme for future years. There is a wealth of evidence to highlight the importance and value of formative assessments; however, particularly for foundation doctors, these have typically been focused on assessing clinical capabilities. This HEKSS initiative encourages doctors to recognise leadership opportunities at the beginning of their careers, seeks to help them understand the importance of acquiring leadership skills and provides structured feedback to help them improve. Leadership education for doctors in training is still in its infancy. © 2015 John Wiley & Sons Ltd.

  13. ‘You can't be a person and a doctor’: the work–life balance of doctors in training—a qualitative study

    Science.gov (United States)

    Viney, Rowena; Needleman, Sarah; Griffin, Ann

    2016-01-01

    Objectives Investigate the work–life balance of doctors in training in the UK from the perspectives of trainers and trainees. Design Qualitative semistructured focus groups and interviews with trainees and trainers. Setting Postgraduate medical training in London, Yorkshire and Humber, Kent, Surrey and Sussex, and Wales during the junior doctor contract dispute at the end of 2015. Part of a larger General Medical Council study about the fairness of postgraduate medical training. Participants 96 trainees and 41 trainers. Trainees comprised UK graduates and International Medical Graduates, across all stages of training in 6 specialties (General Practice, Medicine, Obstetrics and Gynaecology, Psychiatry, Radiology, Surgery) and Foundation. Results Postgraduate training was characterised by work–life imbalance. Long hours at work were typically supplemented with revision and completion of the e-portfolio. Trainees regularly moved workplaces which could disrupt their personal lives and sometimes led to separation from friends and family. This made it challenging to cope with personal pressures, the stresses of which could then impinge on learning and training, while also leaving trainees with a lack of social support outside work to buffer against the considerable stresses of training. Low morale and harm to well-being resulted in some trainees feeling dehumanised. Work–life imbalance was particularly severe for those with children and especially women who faced a lack of less-than-full-time positions and discriminatory attitudes. Female trainees frequently talked about having to choose a specialty they felt was more conducive to a work–life balance such as General Practice. The proposed junior doctor contract was felt to exacerbate existing problems. Conclusions A lack of work–life balance in postgraduate medical training negatively impacted on trainees' learning and well-being. Women with children were particularly affected, suggesting this group would

  14. Development of tailor-made silica fibres for TL dosimetry

    International Nuclear Information System (INIS)

    Bradley, D.A.; Abdul Sani, Siti F.; Alalawi, Amani I.; Jafari, S.M.; Noor, Noramaliza M.; Hairul Azhar, A.R.; Mahdiraji, Ghafour Amouzad; Tamchek, Nizam; Ghosh, S.; Paul, M.C.; Alzimami, Khalid S.; Nisbet, A.; Maah, M.J.

    2014-01-01

    The Ge dopant in commercially available silica optical fibres gives rise to appreciable thermoluminscence (TL), weight-for-weight offering sensitivity to MV X-rays several times that of the LiF dosimeter TLD100. The response of these fibres to UV radiation, X-rays, electrons, protons, neutrons and alpha particles, with doses from a fraction of 1 Gy up to 10 kGy, have stimulated further investigation of the magnitude of the TL signal for intrinsic and doped SiO 2 fibres. We represent a consortium effort between Malaysian partners and the University of Surrey, aimed at production of silica fibres with specific TL dosimetry applications, utilizing modified chemical vapour deposition (MCVD) doped silica–glass production and fibre-pulling facilities. The work is informed by defect and dopant concentration and various production dependences including pulling parameters such as temperature, speed and tension; the fibres also provide for spatial resolutions down to <10 µm, confronting many limitations faced in use of conventional (TL) dosimetry. Early results are shown for high spatial resolution (∼0.1 mm) single-core Ge-doped TL sensors, suited to radiotherapy applications. Preliminary results are also shown for undoped flat optical fibres of mm dimensions and Ge-B doped flat optical fibres of sub-mm dimensions, with potential for measurement of doses in medical diagnostic applications. - Highlights: • Optical fibres tailor-made for TL dosimetry. • Sensitive to diagnostic as well as therapy doses in medicine. • Preform and fibre pulling facilities. • Relative TL and EPR measurements

  15. Software applications for flux balance analysis.

    Science.gov (United States)

    Lakshmanan, Meiyappan; Koh, Geoffrey; Chung, Bevan K S; Lee, Dong-Yup

    2014-01-01

    Flux balance analysis (FBA) is a widely used computational method for characterizing and engineering intrinsic cellular metabolism. The increasing number of its successful applications and growing popularity are possibly attributable to the availability of specific software tools for FBA. Each tool has its unique features and limitations with respect to operational environment, user-interface and supported analysis algorithms. Presented herein is an in-depth evaluation of currently available FBA applications, focusing mainly on usability, functionality, graphical representation and inter-operability. Overall, most of the applications are able to perform basic features of model creation and FBA simulation. COBRA toolbox, OptFlux and FASIMU are versatile to support advanced in silico algorithms to identify environmental and genetic targets for strain design. SurreyFBA, WEbcoli, Acorn, FAME, GEMSiRV and MetaFluxNet are the distinct tools which provide the user friendly interfaces in model handling. In terms of software architecture, FBA-SimVis and OptFlux have the flexible environments as they enable the plug-in/add-on feature to aid prospective functional extensions. Notably, an increasing trend towards the implementation of more tailored e-services such as central model repository and assistance to collaborative efforts was observed among the web-based applications with the help of advanced web-technologies. Furthermore, most recent applications such as the Model SEED, FAME, MetaFlux and MicrobesFlux have even included several routines to facilitate the reconstruction of genome-scale metabolic models. Finally, a brief discussion on the future directions of FBA applications was made for the benefit of potential tool developers.

  16. Cationic lipid-based nanoparticles mediate functional delivery of acetate to tumor cells in vivo leading to significant anticancer effects

    Directory of Open Access Journals (Sweden)

    Brody LP

    2017-09-01

    Full Text Available Leigh P Brody,1,* Meliz Sahuri-Arisoylu,1,* James R Parkinson,1 Harry G Parkes,2 Po Wah So,3 Nabil Hajji,4 E Louise Thomas,1 Gary S Frost,5 Andrew D Miller,6,* Jimmy D Bell1,* 1Department of Life Sciences, Faculty of Science and Technology, University of Westminster, 2CR-UK Clinical MR Research Group, Institute of Cancer Research, Sutton, Surrey, 3Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, 4Department of Medicine, Division of Experimental Medicine, Centre for Pharmacology & Therapeutics, Toxicology Unit, Imperial College London, 5Faculty of Medicine, Nutrition and Dietetic Research Group, Division of Diabetes, Endocrinology and Metabolism, Department of Investigative Medicine, Imperial College London, Hammersmith Hospital, 6Institute of Pharmaceutical Science, King’s College London, London, UK *These authors contributed equally to this work Abstract: Metabolic reengineering using nanoparticle delivery represents an innovative therapeutic approach to normalizing the deregulation of cellular metabolism underlying many diseases, including cancer. Here, we demonstrated a unique and novel application to the treatment of malignancy using a short-chain fatty acid (SCFA-encapsulated lipid-based delivery system – liposome-encapsulated acetate nanoparticles for cancer applications (LITA-CAN. We assessed chronic in vivo administration of our nanoparticle in three separate murine models of colorectal cancer. We demonstrated a substantial reduction in tumor growth in the xenograft model of colorectal cancer cell lines HT-29, HCT-116 p53+/+ and HCT-116 p53-/-. Nanoparticle-induced reductions in histone deacetylase gene expression indicated a potential mechanism for these anti-proliferative effects. Together, these results indicated that LITA-CAN could be used as an effective direct or adjunct therapy to treat malignant transformation in vivo. Keywords: lipid-based nanoparticles, liposomes

  17. The effectiveness of a long-term professional development program on teachers' self-efficacy, attitudes, skills, and knowledge using a thematic learning approach

    Science.gov (United States)

    Tinnin, Richard Kinna

    The purpose of this research study was to determine the effectiveness of a long-term professional development program on self-efficacy beliefs, science attitudes, skills, and knowledge of elementary teachers. The target school was located in the Lower Rio Grande Valley of Texas. Major elements of the study included the use of thematic science strands, use of the 5E constructivist-oriented instructional model, a focus on the interdisciplinary nature of the science process skills, and guided, inquiry-based learning experiences. These elements mirror the principles identified as being essential components of effective professional development for mathematics, and science education (Fullan, 1985; Sparks & Loucks-Horsley, 1990; Loucks-Horsley, 1997). The research team was actively involved with the participants for a total of 30 days at their school over the 24 months of the study. During each training, the research team modeled the 5E constructivist-oriented instructional strategy, and the interdisciplinary nature of the science process skills, set up a wide variety of activity centers, and provided the teachers with opportunities to improve their attitudes, skills, and knowledge of the science content, and teaching strategies. The 15 participants completed pre-, post-, and post-post-Leadership Team Surreys. Quantitative data analyses of gain scores measuring level of confidence to teach Marine and Earth Science, content knowledge, and teaching strategies were significant, p .05. Qualitative analysis of reflective journal comments, classroom observations, and the participants understanding, and use of science process skills across the curriculum supported the quantitative data results. The data demonstrate significant improvement in the self-efficacy beliefs, attitudes, skills, and knowledge toward teaching science of the Pre-Kindergarten--2nd -grade teachers who participated in this long-term professional development study.

  18. Table top exercises a teaching and research tool

    International Nuclear Information System (INIS)

    Lakey, J.R.A.

    1990-01-01

    Table Top Exercises have been used in training Command and Control Teams at the Royal Naval College Greenwich for over 10 years since they allow a wide range of scenarios to be reviewed. The exercise commences with the scene setting information and the teams reaction to the information proceeds like a seminar. This technique is surprisingly effective but it lacks feed back and is not necessarily performed in real-time so a formal exercise based on a real accident was designed. The staff solution to the event was derived from the NRC Advisory Documents. The exercise was limited to the Early Phase of a real accident which had occurred in the USA but it was suitably disguised and based on data presented in an information booklet which the trainees were expected to read and digest before the exercise commenced. This exercise has been tested at the University of Surrey, in Sweden and at Harvard University and to date over 200 people have participated. On each application the exercise was modified and it became apparent that real-time environmental data was needed and this was met by the IRDAM code. The code was used initially to extrapolate limited measurements to outer areas of the Emergency Planning Zone. Substantial difficulties emerged for the teams who were not usually qualified nuclear engineers: confusion in the use of radiation units, numeracy of the candidates, inadequate input data, inability to interpret the output and errors made due to stress and communication difficulties. DNST has made some improvements to the interfacing of the codes and these will be reported

  19. Factors contributing to the development of hypophosphataemia when refeeding using parenteral nutrition.

    Science.gov (United States)

    Marvin, Vanessa A; Brown, David; Portlock, Jane; Livingstone, Callum

    2008-08-01

    To identify individual attributes or risk factors which predispose to the development of refeeding hypophosphataemia in patients on parenteral nutrition (PN). The Royal Surrey County Hospital (RSCH) a 530 bed, non-teaching Trust with a cancer centre, medical and surgical inpatients and intensive care unit (ICU). Subjects were recruited prospectively from all adult inpatients referred for initiation of PN. Seventy patients (cases) with refeeding hypophosphataemia were matched with controls who had not experienced a fall in phosphate levels when commenced on PN. Their nutritional requirements, nutrition intake, and biochemical test results were compared and statistical analyses performed to show if any differences between cases and controls were due to chance. Independent risk factors for developing refeeding hypophosphataemia were: significant malnutrition measured as a Nutrition Risk Screening (NRS) score of three or more; less than 12 mmols total phosphate in the first day's PN regimen; and an initial rate of infusion of PN of more than 70% of calculated requirements. In addition increasing amounts of non-lipid phosphate in the first day's PN regimen were found to be protective. Hypomagnesaemia prior to starting PN was non-significantly associated with refeeding hypophosphataemia. Other biochemical markers included in the study: albumin, calcium, C-reactive protein, glucose and urea, did not show an association. ICU, cancer and postoperative patients were not found to be more at risk. Patients with a high NRS score prior to commencing nutrition support may be more at risk than others of refeeding hypophosphataemia. The first 24 h PN regimen should be run slowly providing less than 70% of calculated protein and calorie requirements but containing more than 12 mmol phosphate.

  20. Hemispherical Scanning Imaging DOAS: Resolving nitrogen dioxide in the urban environment

    Science.gov (United States)

    Leigh, R. J.; Graves, R. R.; Lawrence, J.; Faloon, K.; Monks, P. S.

    2012-12-01

    Imaging DOAS techniques have been used for nitrogen dioxide and sulfer dioxide for a number of years. This presentation describes a novel system which images concentrations of nitrogen dioxide by scanning an imaging spectrometer 360 degrees azimuthally, covering a region from 5 degrees below the horizon, to the zenith. The instrument has been built at the University of Leicester (UK), on optical designs by Surrey Satellite Technologies Ltd, and incorporates an Offner relay with Schwarzchild fore-optics, in a rotating mount. The spectrometer offers high fidelity spectroscopic retrievals of nitrogen dioxide as a result of a reliable Gaussian line shape, zero smile and low chromatic aberration. The full hemispherical scanning provides complete coverage of nitrogen dioxide concentrations above approximately 5 ppbv in urban environments. Through the use of multiple instruments, the three-dimensional structure of nitrogen dioxide can be sampled and tomographically reconstructed, providing valuable information on nitrogen dioxide emissions and downwind exposure, in addition to new understanding of boundary layer dynamics through the use of nitrogen dioxide as a tracer. Furthermore, certain aerosol information can be retrieved through absolute intensity measurements in each azimuthal direction supplemented by traditional techniques of O4 spectroscopy. Such measurements provide a new tool for boundary layer measurement and monitoring at a time when air quality implications on human health and climate are under significant scrutiny. This presentation will describe the instrument and tomographic potential of this technique. First measurements were taken as part of the international PEGASOS campaign in Bologna, Italy. Results from these measurements will be shown, including imaging of enhanced NO2 in the Bologna urban boundary layer during a severe thunderstorm. A Hemispherical Scanning Imaging DOAS instrument operating in Bologna, Italy in June 2012. Visible in the background

  1. CRUMB TEXTURE OF SPELT BREAD

    Directory of Open Access Journals (Sweden)

    Joanna Korczyk-Szabó

    2013-12-01

    Full Text Available Abstract The bread quality is considerably dependent on the texture characteristic of bread crumb. Crumb texture is an important quality indicator, as consumer prefer different bread taste. Texture analysis is primarily concerned with the evaluation of mechanical characteristics where a material is subjected to a controlled force from which a deformation curve of its response is generated. It is an objective physical examination of baked products and gives direct information on the product quality, oppositely to dough rheology tests what inform on the baking suitability of the flour, as raw material. This is why the texture analysis is one of the most helpful analytical methods of the product development. In the framework of our research during the years 2008 – 2009 were analyzed selected indicators for bread texture quality of five Triticum spelta L. varieties – Altgold, Oberkulmer Rotkorn, Ostro, Rubiota and Franckenkorn grown in an ecological system. The bread texture quality was evaluated on texture analyzer TA.XT Plus (Stable Micro Systems, Surrey, UK, following the AACC (74-09 standard method and expressed as crumb firmness (N, stiffness (N.mm-1 and relative elasticity (%. Our research proved that all selected indicators were significantly influenced by the year of growing and variety. The most soft bread was achieved in Rubiota, whereas bread crumb samples from Franckenkorn and Altgold were the most firm and stiff. Correlation analysis showed strong negative correlation between relative elasticity and bread crumb firmness as well as bread stiffness (-0.81++, -0.78++. The spelt grain can be a good source for making bread flour, but is closely dependent on choice of spelt variety. The spelt wheat bread crumb texture need further investigation as it can be a reliable quality parameter.

  2. Transcriptional activity of telomerase complex in CD34- stem cells of cord blood in dependence of preparation time.

    Directory of Open Access Journals (Sweden)

    M Bojdys-Szyndlar

    2009-12-01

    Full Text Available The aim of the study was to determine whether the expression of telomerase subunits encoding genes changes during the process of cord blood preparation. It should establish if the commonly accepted 24 hours time interval in stem cells kriopreservation procedure significantly influences their immortalization and so decreases the "quality" of cord blood stem cells. Investigation includes 69 women. Spontaneous labour was the inclusion condition. The material was collected at birth after clamping of umbilical cord by direct vasopuncture. CD34- cells were extracted from cord blood (MACS, Miltenyi Biotec; Bisley, Surrey, UK. The expression profile of telomerase activators and inhibitors encoding genes was determined using HG_U133A oligonucleotide microarray (Affymetrix. We used a real-time quantitative RT-PCR assay to quantify the telomerase TERT, hTR and TP1 subunits mRNA copy numbers in CD34- cells in 0, 6, 12 and 24 hours after cord blood collection. We observed significant decrease of numbers of copies of TERTA+B mRNA within the successive hours of observation. Significant decrease of numbers of TERTA mRNA copies was confirmed after 24 hours. However, we observed significant increase of numbers of copies of TERTB mRNA after 6 hours of observation. Similar level was maintained during another 6h. The significantly lower number of copies of TERTB mRNA was observed after 24h. We also observed significant increase of number of copies of TERT mRNA after 6 hours. Number of copies of TERT mRNA significantly decreased after another 6h, remaining, however, on a higher then initial one. The significant lower number of copies of TERT mRNA was observed 24h after delivery. The possible explanation of those results is discussed in the paper.

  3. Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients

    Directory of Open Access Journals (Sweden)

    Novick D

    2016-04-01

    Full Text Available Diego Novick,1 William Montgomery,2 Jaume Aguado,3 Xiaomei Peng,4 Josep Maria Haro3 1Eli Lilly and Company, Windlesham, Surrey, UK; 2Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 3Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain; 4Eli Lilly and Company, Indianapolis, IN, USA Objective: To investigate the impact of anxiety symptoms on depression outcomes in Asian patients with major depressive disorder (MDD (n=714. Methods: The 17-item Hamilton Depression Scale (HAMD-17, overall severity, somatic symptoms, and quality of life (QOL (EuroQOL Questionnaire-5 Dimensions [EQ-5D] were assessed at baseline and 3 months. Anxiety was measured using items 10 and 11 from the HAMD-17. Linear, tobit, and logistic multiple regression models analyzed the impact of anxiety symptoms on outcomes. Baseline anxiety was related to age and the presence of pain symptoms at baseline. Results: Regression models showed that a higher level of anxiety was associated with a lower frequency of remission and lower QOL at 3 months. Patients with lower baseline anxiety symptoms had higher remission rates (odds ratio for each point of anxiety symptoms, 0.829 [95% confidence interval [CI]: 0.723–0.951]. Patients with higher levels of baseline anxiety had a lower QOL at 3 months (a decrease in EQ-5D tariff score for each point of anxiety symptoms, 0.023 [95% CI: 0.045–0.001]. Conclusion: In conclusion, the presence of anxiety symptoms negatively impacts the outcomes of depression. Keywords: depression, anxiety, Asia, observational, outcomes

  4. Susceptibility to cartap-induced lethal effect and diaphragmatic injury via ocular exposure in rabbits.

    Science.gov (United States)

    Liao, Jiunn-Wang; Pang, Victor Fei; Jeng, Chian-Ren; Chang, Shao-Kuang; Hwang, Jenn-Sheng; Wang, Shun-Cheng

    2003-11-05

    Cartap is extensively used to control agricultural pests. Pertinent literatures have indicated that it causes no eye irritation [D.E. Ray, Insecticides derived from plants and other organisms, in: W.J. Hayes, E.R. Laws (Eds.), Handbook of Insecticide Toxicology, Classes of Insecticides, vol. 2, Academic Press, New York, 1991, p. 611; C. Tomlin, Cartap, in: C. Tomlin (Ed.), The Insecticide Manual, 12th ed., British Crop Protection Council, Surrey, UK, 2000, p. 144]; however, the instillation of a little cartap through the eye has caused death in rabbits. The aim of this study was to determine the ocular toxicity of cartap in New Zealand White rabbits. Cartap was directly instilled into the low conjunctival sac of eyes, at doses of 0, 5, 7.5, 10 and 12.5 mg/kg body weight. The changes in the enzymes and isoenzymes of creatine kinase (CK), lactate dehydrogenase (LD), as well as pathological changes in the muscles of the heart, thigh and diaphragm were determined in the cartap-treated rabbits. Moreover, the neuromuscular effect of cartap was examined using the isolated rabbit phrenic-nerve diaphragm model. The results indicated that rabbits developed severe signs and they died within 20 min of ocular instillation. The ocular LD50 of cartap was 8.1 mg/kg body weight. Treatment with cartap increased the activities of CK and LD enzymes and their isoenzymes, CK-1, CK-2, and CK-3 in serum, and CK-3 and LD-5 in the diaphragm. Microscopically, hypercontraction bands and the rupture of myofibers of the diaphragm were observed in dead rabbits. Cartap did not affect nerve-evoked twitch but induced irreversible contracture and twitch depression on the isolated rabbit's diaphragm. These results indicate that the rabbit is susceptible to cartap toxicity; the effect of cartap caused contracture and damage to the diaphragm might play a pivotal role in respiratory paralysis and death of rabbits during intoxication.

  5. Status and Update of the RaDIATE Collaboration R&D Program

    Energy Technology Data Exchange (ETDEWEB)

    Ammigan, K. [Fermilab; Hurh, P. [Fermilab

    2017-07-01

    The Radiation Damage In Accelerator Target Environments (RaDIATE) collaboration was founded in 2012 and currently consists of over 50 participants and 11 institutions globally. Due to the increasing power of future proton accelerator sources in target facilities, there is a critical need to further understand the physical and thermo-mechanical radiation response of target facility materials. Thus, the primary objective of the RaDIATE collaboration is to draw on existing expertise in the nuclear materials and accelerator targets fields to generate new and useful materials data for application within the accelerator and fission/fusion communities. Current research activities of the collaboration include post irradiation examination (PIE) of decommissioned components from existing beamlines such as the NuMI beryllium beam window and graphite NT-02 target material. PIE of these components includes advanced microstructural analyses (SEM/TEM, EBSD, EDS) and micro-mechanics technique such as nano-indentation, to help characterize any microstructural radiation damage incurred during operation. New irradiation campaigns of various candidate materials at both low and high energy beam facilities are also being pursued. Beryllium helium implantation studies at the University of Surrey as well as high energy proton irradiation of various materials at Brookhaven National Laboratory’s BLIP facility have been initiated. The program also extends to beam-induced thermal shock experiments using high intensity beam pulses at CERN’s HiRadMat facility, followed by advanced PIE activities to evaluate thermal shock resistance of the materials. Preliminary results from ongoing research activities, as well as the future plans of the RaDIATE collaboration R&D program will be discussed.

  6. Oxford and Cambridge Boat Race: Performance, Pacing and Tactics Between 1890 and 2014.

    Science.gov (United States)

    Edwards, Andrew M; Guy, Joshua H; Hettinga, Florentina J

    2016-10-01

    Currently no studies have examined the historical performances of Oxford and Cambridge Boat Race crews in the context of performance, pacing and tactics which is surprising as the event has routinely taken place annually for over 150 years on the same course. The purpose of this study was twofold, to firstly examine the historical development of performances and physical characteristics of crews over 124 years of the Oxford and Cambridge Boat Race between 1890 and 2014 and secondly to investigate the pacing and tactics employed by crews over that period. Linear regression modelling was applied to investigate the development of performance and body size for crews of eight male individuals over time from Boat Race archive data. Performance change over time was further assessed in 10-year clusters while four intra-race checkpoints were used to examine pacing and tactics. Significant correlations were observed between performance and time (1890-2014) for both Oxford (r = -0.67; p tactical advantage from commencing on either the Surrey or Middlesex station beyond chance alone; however, all crews (n = 228) adopted a fast-start strategy, with 81 % of victories achieved by the crew leading the race at the first intra-race checkpoint (24 % of total distance). Crews leading the race at the final checkpoint (83 % of total distance; 1143 m) achieved victory on 94 % of occasions. Performances and physical characteristics of the crews have changed markedly since 1890, with faster heavier crews now common. Tactically, gaining the early lead position with a fast-start strategy seems particularly meaningful to success in the Boat Race throughout the years, and has been of greater importance to race outcome than factors such as the starting station.

  7. Organization of lasers with particle accelerators to create new tools for frontier sciences

    International Nuclear Information System (INIS)

    Nakajima, Kazuhisa; Kando, Masaki; Kotaki, Hideyuki; Kondo, Shuji; Kanazawa, Shuhei; Masuda, Shinichi; Honma, Takayuki

    2003-01-01

    channel produced by an imploding phase of fast Z-pinch discharge in a gap-filled capillary. Recently novel schemes which use laser triggered injection of plasma electrons into the wakefield have been proposed as a plasma cathode. As a first step of this plasma cathode development, we present the first direct observation of 20 GeV/m of coherent ultrahigh gradient wakefields excited by a 2 TW, 50 fs laser pulse in a gas jet as well as precise measurements of its time-resolved gas density distribution. In the PIC simulations of the colliding pulse injection, a remarkable beam quality is verified with ultrahigh peak brightness and ultrashort pulse required of next generation particle accelerators and free electron lasers. At present the laser acceleration experiments have begun with 100 TW, 20 fs laser pulses focused on the gas jet plasma target. (author)

  8. Crystal structure of the extracellular domain of human myelin protein zero

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Zhigang; Wang, Yong; Yedidi, Ravikiran S.; Brunzelle, Joseph S.; Kovari, Iulia A.; Sohi, Jasloveleen; Kamholz, John; Kovari, Ladislau C. (WSU-MED); (NWU)

    2012-03-27

    different mutations in the MPZ gene leading to peripheral neuropathy in patients have been reported worldwide (http://www.molgen. ua.ac.be/CMTMutations). All identified mutations resulting in a change or deletion of amino acid residues in MPZ give rise to neuropathy with the exception of R215L, which instead causes a benign polymorphism. Furthermore, more detailed analysis has classified the MPZ mutations into two major groups. In the first group, the mutations disrupt the intracellular processing of MPZ and are primarily associated with early onset neuropathy. It has been proposed that the mutated MPZ is trapped inside the cell rather than being transported to the plasma membrane. However, other evidence suggests that the mutated MPZ protein is expressed on the plasma membrane, but dominant-negatively disrupts the structure of myelin. In the second group, the MPZ mutations are associated with late onset neuropathy as these mutations cause only mild demyelination. The underlying mechanism is elusive with the hypothesis being that the second group of mutations cause minor abnormalities in the myelin sheath that over time may lead to aberrant Schwann cell-axon interactions and subsequently to axonal degeneration. The crystal structure of the extracellular domain of human MPZ (hP0ex) fused with maltose binding protein (MBP) is reported at 2.1 {angstrom} resolution. While the crystal structure of rat MPZ extracellular domain (rP0ex) is available, the crystal structure of the human counterpart is useful for the analysis of the two homologs as well as a comparison between the two species. The hP0ex molecule reveals subtle structural variations between two homologs allowing comparison of the human myelin protein zero to that of the rat protein. The alignment of these homologs is shown in Figure 1(a).

  9. Pulp chamber temperature rise during curing of resin-based composites with different light-curing units.

    Science.gov (United States)

    Durey, Kathryn; Santini, Ario; Miletic, Vesna

    2008-01-01

    The purpose of the present study was to measure the intrapulpal temperature rise occurring during polymerisation of different shades of resin-based composites (RBCs), and two light-emitting diode (LED) units. Seventy non-carious permanent molars, that had been extracted for orthodontic purposes and stored in 2% thymol for not more than four months, were selected. Patient age range was 11-18 years. Standard cavity preparation with standardised remaining dentine thickness and placement of thermocouples (TCs) was prepared using a novel split-tooth technique. Cavities were filled with one of two shades of RBC (A2 and C4, Filtek Z250, 3M ESPE, Seefeld, Germany), and cured with two LED high-intensity units (Elipar Freelight2, 3M ESPE, Seefeld, Germany; Bluephase, Ivoclar Vivadent, Schaan, Liechtenstein) and a conventional halogen light-curing unit (LCU) (Prismetics Lite 2, Dentsply, Weybridge, Surrey, UK) as a control. Pulp temperature rises during bonding [A2 results: H;2.67/0.48:E;5.24/1.32;B;5.99/1.61] were always greater than during RBC curing [A2 results: 2.44/0.63;E3.34/0.70;B3.38/0.60], and these were significant for both LED lights but not for the halogen control, irrespective of shade (Mann-Whitney test: 95% confidence limits). Temperature rises were at times in excess of the values normally quoted as causing irreversible pulp damage. Pulp temperature rises during bonding were higher with the LED lights than with the halogen control. There was no significant difference in temperature rise between the two LED lights when bonding but there was a significant difference between the two LED lights and the halogen control LCUs (Kruskal-Wallis Test: 95% confidence limits). The results support the view that there is a potential risk for heat-induced pulpal injury when light-curing RBCs. The risk is greater during bonding and with high energy, as compared to low-energy output systems. As the extent of tolerable thermal trauma by the pulp tissues is unknown, care and

  10. Productivity loss and resource utilization, and associated indirect and direct costs in individuals providing care for adults with schizophrenia in the EU5

    Directory of Open Access Journals (Sweden)

    Gupta S

    2015-11-01

    Full Text Available Shaloo Gupta,1 Gina Isherwood,2 Kevin Jones,3 Kristel Van Impe4 1Kantar Health, Princeton, NJ, USA; 2Kantar Health, Epsom, Surrey, UK; 3European Federation of Associations of Families of People with Mental Illness, Diestsevest, Leuven, Belgium; 4Janssen-Cilag GmbH, Neuss, Germany Objective: This study aimed to understand the impact of providing care for adults with schizophrenia on productivity, resource utilization, and costs in the EU5 (France, Germany, Italy, Spain, and UK. Methods: Data from the 2010, 2011, and 2013 EU5 National Health and Wellness Survey, an online questionnaire of a nationwide sample of adults, were analyzed. Schizophrenia caregivers (n=398 were matched to noncaregivers (n=158,989 and other caregivers (n=14,341 via propensity scores. Outcome measures included health care utilization, Work Productivity and Activity Impairment questionnaire-based scores, and associated direct and indirect costs (estimated from the literature. Significant differences between schizophrenia caregivers vs noncaregivers and other caregivers (eg, cancer and Alzheimer's disease were examined. Results: After matching, schizophrenia caregivers reported greater activity impairment (38.4% vs 26.1%, provider visits (8.0 vs 5.7, emergency room visits (0.9 vs 0.2, hospitalizations (0.8 vs 0.1, and direct costs (€2,258 vs €617 than noncaregivers, all P<0.001. Employed schizophrenia caregivers reported greater absenteeism, presenteeism, overall work impairment (35.0% vs 20.7%, and indirect costs (€6,667 vs €3,795 than noncaregivers, all P<0.001. Schizophrenia caregivers (vs other caregivers reported greater activity impairment (38.4% vs 32.3% and provider visits (8.0 vs 6.6, P<0.05. A greater proportion of schizophrenia caregivers (vs other caregivers reported at least one emergency room visit (26.1% vs 20.2% and hospitalization (20.4% vs 14.3%, P<0.05. Employed schizophrenia caregivers incurred greater indirect costs than other caregivers (€6

  11. Screening for type 2 diabetes in a multiethnic setting using known risk factors to identify those at high risk: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Laura J Gray

    2010-09-01

    Full Text Available Laura J Gray1, Jennifer R Tringham2, Melanie J Davies3, David R Webb3, Janet Jarvis4, Timothy C Skinner5, Azhar M Farooqi1, Kamlesh Khunti11Department of Health Sciences, University of Leicester, Leicester, UK; 2Department of Diabetes, Frimley Park Hospital, Surrey, UK; 3Department of Cardiovascular Sciences, University Hospitals of Leicester, Leicester, UK; 4University Hospitals Leicester, Leicester, UK; 5Flinders University Rural Clinical School, Flinders University, Renmark, AustraliaIntroduction: Screening enables the identification of type 2 diabetes mellitus (T2DM during its asymptomatic stage and therefore allows early intervention which may lead to fewer complications and improve outcomes. A targeted screening program was carried out in a United Kingdom (UK multiethnic population to identify those with abnormal glucose tolerance.Methods: A sample of individuals aged 25–75 years (40–75 white European with at least one risk factor for T2DM were invited for screening from 17 Leicestershire (UK general practices or through a health awareness campaign. All participants received a 75 g oral glucose tolerance test, cardiovascular risk assessment, detailed medical and family histories and anthropometric measurements.Results: In the 3,225 participants who were screened. 640 (20% were found to have some form of abnormal glucose tolerance of whom 4% had T2DM, 3% impaired fasting glucose (IFG, 10% impaired glucose tolerance (IGT and 3% both IFG and IGT. The odds of detecting IGT was approximately 60% greater (confounder-adjusted odds ratios [OR] 1.67 [1.22–2.29] in the South Asian population.Conclusions: Around one in five people who had targeted screening have IGT, IFG or T2DM, with a higher prevalence in those of South Asian origin. The prevalence of undetected T2DM is lower in South Asians compared to previously published studies and maybe due to increased awareness of this group being at high risk.Keywords: type 2 diabetes, screening

  12. Exploring older adults’ perceptions of a patient-centered education manual for hip fracture recovery: “everything in one place”

    Directory of Open Access Journals (Sweden)

    Tsui K

    2015-11-01

    Full Text Available Karen Tsui,1,2,* Lena Fleig,1,3,4,* Dolores P Langford,2,5 Pierre Guy,1,2,6 Valerie MacDonald,7,8 Maureen C Ashe1,31Centre for Hip Health and Mobility, The University of British Columbia, 2Vancouver Coastal Health, 3Department of Family Practice, The University of British Columbia, Vancouver, BC, Canada; 4Health Psychology, Freie Universität Berlin, Berlin, Germany; 5Department of Physical Therapy, The University of British Columbia, 6Department of Orthopaedics, 7School of Nursing, The University of British Columbia, Vancouver, 8Fraser Health Authority, Surrey, BC, Canada*These authors contributed equally to this workPurpose: To describe older adults’ perspectives on a new patient education manual for the recovery process after hip fracture.Materials and methods: The Fracture Recovery for Seniors at Home (FReSH Start manual is an evidence-based manual for older adults with fall-related hip fracture. The manual aims to support the transition from hospital to home by facilitating self-management of the recovery process. We enrolled 31 community-dwelling older adults with previous fall-related hip fracture and one family member. We collected data using a telephone-based questionnaire with eight five-point Likert items and four semi-structured open-ended questions to explore participants’ perceptions on the structure, content, and illustration of the manual. The questionnaire also asked participants to rate the overall utility (out of 10 points and length of the manual. We used content analysis to describe main themes from responses to the open-ended interview questions.Results: Participants’ ratings for structure, content, and illustrations ranged from 4 to 5 (agree to highly agree, and the median usefulness rating was 9 (10th percentile: 7, 90th percentile: 10. Main themes from the content analysis included: ease of use and presentation; health literacy; illustration utility; health care team delivery; general impression, information

  13. Analysis of state-of-the-art single-thruster attitude control techniques for spinning penetrator

    Science.gov (United States)

    Raus, Robin; Gao, Yang; Wu, Yunhua; Watt, Mark

    2012-07-01

    The attitude dynamics and manoeuvre survey in this paper is performed for a mission scenario involving a penetrator-type spacecraft: an axisymmetric prolate spacecraft spinning around its minor axis of inertia performing a 90° spin axis reorientation manoeuvre. In contrast to most existing spacecraft only one attitude control thruster is available, providing a control torque perpendicular to the spin axis. Having only one attitude thruster on a spinning spacecraft could be preferred for spacecraft simplicity (lower mass, lower power consumption etc.), or it could be imposed in the context of redundancy/contingency operations. This constraint does yield restrictions on the thruster timings, depending on the ratio of minor to major moments of inertia among other parameters. The Japanese Lunar-A penetrator spacecraft proposal is a good example of such a single-thruster spin-stabilised prolate spacecraft. The attitude dynamics of a spinning rigid body are first investigated analytically, then expanded for the specific case of a prolate and axisymmetric rigid body and finally a cursory exploration of non-rigid body dynamics is made. Next two well-known techniques for manoeuvring a spin-stabilised spacecraft, the Half-cone/Multiple Half-cone and the Rhumb line slew, are compared with two new techniques, the Sector-Arc Slew developed by Astrium Satellites and the Dual-cone developed at Surrey Space Centre. Each technique is introduced and characterised by means of simulation results and illustrations based on the penetrator mission scenario and a brief robustness analysis is performed against errors in moments of inertia and spin rate. Also, the relative benefits of each slew algorithm are discussed in terms of slew accuracy, energy (propellant) efficiency and time efficiency. For example, a sequence of half-cone manoeuvres (a Multi-half-cone manoeuvre) tends to be more energy-efficient than one half-cone for the same final slew angle, but more time-consuming. As another

  14. Vitamin D deficiency in UK South Asian Women of childbearing age: a comparative longitudinal investigation with UK Caucasian women.

    Science.gov (United States)

    Darling, A L; Hart, K H; Macdonald, H M; Horton, K; Kang'ombe, A R; Berry, J L; Lanham-New, S A

    2013-02-01

    This is the first 1-year longitudinal study which assesses vitamin D deficiency in young UK-dwelling South Asian women. The findings are that vitamin D deficiency is extremely common in this group of women and that it persists all year around, representing a significant public health concern. There is a lack of longitudinal data assessing seasonal variation in vitamin D status in young South Asian women living in northern latitudes. Studies of postmenopausal South Asian women suggest a lack of seasonal change in 25-hydroxy vitamin D [25(OH)D], although it is unclear whether this is prevalent among premenopausal South Asians. We aimed to evaluate, longitudinally, seasonal changes in 25(OH)D and prevalence of vitamin D deficiency in young UK-dwelling South Asian women as compared with Caucasians. We also aimed to establish the relative contributions of dietary vitamin D and sun exposure in explaining serum 25(OH)D. This is a 1-year prospective cohort study assessing South Asian (n = 35) and Caucasian (n = 105) premenopausal women living in Surrey, UK (51° N), aged 20-55 years. The main outcome measured was serum 25(OH)D concentration. Secondary outcomes were serum parathyroid hormone, self-reported dietary vitamin D intake and UVB exposure by personal dosimetry. Serum 25(OH)D Asians in the winter (81 %) and autumn (79.2 %). Deficient status (below 50 nmol/L) was common in Caucasian women. Multi-level modelling suggested that, in comparison to sun exposure (1.59, 95 %CI = 0.83-2.35), dietary intake of vitamin D had no impact on 25(OH)D levels (-0.08, 95 %CI = -1.39 to 1.23). Year-round vitamin D deficiency was extremely common in South Asian women. These findings pose great health threats regarding the adverse effects of vitamin D deficiency in pregnancy and warrant urgent vitamin D public health policy and action.

  15. Mental health research in the criminal justice system: The need for common approaches and international perspectives.

    Science.gov (United States)

    Roesch, R; Ogloff, J R; Eaves, D

    1995-01-01

    There is a need for researchers and policy makers in the area of mental health and law to collaborate and develop common methods of approach to research. Although we have learned a great deal about the prevalence and needs of mentally ill offenders in jails and prisons, there are a number of research questions that remain. If the "second generation" of research is to be fruitful--and useful to policy makers--we need to be sure that the methods we employ are valid and that the findings we obtain are reliable. By collaborating with colleagues in other jurisdictions, we can begin to learn whether some of the existing findings are of a general nature, or dependent upon the system in which they were found. Similarly, while the first-generation research has alerted us to the needs of mentally ill offenders in jails and prisons, second-generation research is needed to help identify factors that may help prevent the "revolving door phenomenon," which results in mentally ill people being volleyed among mental health, criminal justice, and community settings. One area that has received embarrassingly little attention has been the need for considering the relationship between substance abuse and mental disorders. In our own work, we have found an alarmingly high degree of substance abuse among offenders, including mentally ill offenders. We have come to realize the importance of considering the role that substance abuse coupled with other mental disorders may play in the criminal justice system. As a result of this concern, the Surrey Mental Health Project recently hired a full-time drug and alcohol counselor whose job it is to work with inmates with substance abuse disorders while in the jail, and to help arrange continuing treatment resources upon their release. As Wilson et al. (1995) discuss, intensive case management projects may be particularly useful at targeting the unique needs of mentally ill offenders with multiple problems. Much of the research conducted with

  16. Do concomitant pain symptoms in patients with major depression affect quality of life even when taking into account baseline depression severity?

    Directory of Open Access Journals (Sweden)

    Novick D

    2013-05-01

    Full Text Available Diego Novick,1 William Montgomery,2 Zbigniew Kadziola,3 Victoria Moneta,4 Xiaomei Peng,5 Roberto Brugnoli,6 Josep Maria Haro41Eli Lilly and Company, Windlesham, Surrey, UK; 2Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 3Eli Lilly Austria GmbH, Vienna, Austria; 4Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain; 5Eli Lilly and Company, Indianapolis, IN, USA; 6Università di Roma, “Sapienza,” Rome, ItalyBackground: Patients with major depressive disorder (MDD may suffer from concomitant pain symptoms. The aim of this study is to determine whether the presence of painful physical symptoms (PPS influences quality of life when taking into account baseline depression severity.Methods: Patients with a new or first episode of MDD (n = 909 were enrolled in a 3-month prospective observational study in East Asia. The Hamilton Depression Rating Scale, Clinical Global Impression-Severity score, Somatic Symptom Inventory, and EuroQoL questionnaire-5 Dimensions (EQ-5D and EQ-Visual Analogue Scale (EQ-VAS were assessed at baseline and 3 months’ follow-up. The presence of PPS was defined as a mean score of ≥2 on the Somatic Symptom Inventory pain-related items. Regression analyses determined predictors of quality of life at 3 months, adjusting for age, sex, depressive symptoms, overall severity, and quality of life at baseline.Results: PPS were present (PPS+ at baseline in 52% of patients. During the 3-month follow-up, EQ-VAS scores improved from 47.7 (standard deviation [SD] 20.6 to 72.5 (SD 20.4, and EQ-5D improved from 0.48 (SD 0.34 to 0.80 (SD 0.26. At 3 months, mean EQ-VAS was 66.4 (SD 21.2 for baseline PPS+ patients versus 78.5 (SD 17.6 for baseline PPS- patients, and mean EQ-5D was 0.71 (SD 0.29 versus 0.89 (SD 0.18. PPS+ at baseline was a significant predictor of quality of life at 3 months after adjusting for sociodemographic and baseline clinical variables

  17. The influence of weather and environment on pulmonary embolism: pollutants and fossil fuels.

    Science.gov (United States)

    Clauss, Ralf; Mayes, Julian; Hilton, Paul; Lawrenson, Ross

    2005-01-01

    Previous publications have highlighted seasonal variations in the incidence of thrombosis and pulmonary embolism, and that weather patterns can influence these. While medical risk factors for pulmonary thrombo-embolism such as age, obesity, hypercoagulable states, cancer, previous thrombo-embolism, immobility, limb paralysis, surgery, major illness, trauma, hypotension, tachypnoea and right ventricular hypokinesis are not directly implicated regarding environmental factors such as weather, they could be influenced indirectly by these. This would be especially relevant in polluted areas that are associated with a higher pulmonary embolism risk. Routine nuclear medicine lung ventilation/perfusion studies (V/Q scans) of 2071 adult patients referred to the nuclear medicine department of the Royal Surrey County Hospital in Guildford, UK, between January 1998 and October 2002 were reviewed and 316 of these patients were classified as positive for pulmonary embolism with high probability scan on PIOPED criteria. The occurrence of positive scans was compared to environmental factors such as temperature, humidity, vapour pressure, air pressure and rainfall. Multiple linear regression was used to establish the significance of these relations. The incidence of pulmonary embolism was positively related to vapour pressure and rainfall. The most significant relation was to vapour pressure (p=0.010) while rainfall was less significant (p=0.017). There was no significant relation between pulmonary embolism and air pressure, humidity or temperature. It is postulated that rainfall and water vapour may be contributary factors in thrombosis and pulmonary embolism by way of pollutants that are carried as condensation nuclei in micro-droplets of water. In particular, fossil fuel pollutants are implicated as these condensation nuclei. Pollutants may be inhaled by populations exposed to windborne vapour droplets in cities or airports. Polluted vapour droplets may be absorbed by the lung

  18. Low-cost autonomous orbit control about Mars: Initial simulation results

    Science.gov (United States)

    Dawson, S. D.; Early, L. W.; Potterveld, C. W.; Königsmann, H. J.

    1999-11-01

    would take the form of solar flux (F10.7) and diurnal density dependencies. The autonomous controller is a-derivative of the proprietary and patented Microcosm Earth-orbiting control methodology which will be implemented on the upcoming Surrey Satellite Technology (SSTL) UoSAT-12 and the NASA EO-1 spacecraft missions. This work was funded by the NASA Jet Propulsion Laboratory under a Phase I SBIR (96.1 07.02 9444) and by internal Microcosm R&D funds as well as earlier supporting work done under a variety of USAF Research Laboratory-sponsored contracts [1, 2, 4, 12].

  19. Clinical development of galunisertib (LY2157299 monohydrate, a small molecule inhibitor of transforming growth factor-beta signaling pathway

    Directory of Open Access Journals (Sweden)

    Herbertz S

    2015-08-01

    Full Text Available Stephan Herbertz,1 J Scott Sawyer,2 Anja J Stauber,2 Ivelina Gueorguieva,3 Kyla E Driscoll,4 Shawn T Estrem,2 Ann L Cleverly,3 Durisala Desaiah,2 Susan C Guba,2 Karim A Benhadji,2 Christopher A Slapak,2 Michael M Lahn21Lilly Deutschland GmbH, Bad Homburg, Germany; 2Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA; 3Lilly Research Laboratories, Eli Lilly and Company, Windlesham, Surrey, UK; 4Lilly Research Laboratories, Eli Lilly and Company, New York, NY, USA Abstract: Transforming growth factor-beta (TGF-β signaling regulates a wide range of biological processes. TGF-β plays an important role in tumorigenesis and contributes to the hallmarks of cancer, including tumor proliferation, invasion and metastasis, inflammation, angiogenesis, and escape of immune surveillance. There are several pharmacological approaches to block TGF-β signaling, such as monoclonal antibodies, vaccines, antisense oligonucleotides, and small molecule inhibitors. Galunisertib (LY2157299 monohydrate is an oral small molecule inhibitor of the TGF-β receptor I kinase that specifically downregulates the phosphorylation of SMAD2, abrogating activation of the canonical pathway. Furthermore, galunisertib has antitumor activity in tumor-bearing animal models such as breast, colon, lung cancers, and hepatocellular carcinoma. Continuous long-term exposure to galunisertib caused cardiac toxicities in animals requiring adoption of a pharmacokinetic/pharmacodynamic-based dosing strategy to allow further development. The use of such a pharmacokinetic/pharmacodynamic model defined a therapeutic window with an appropriate safety profile that enabled the clinical investigation of galunisertib. These efforts resulted in an intermittent dosing regimen (14 days on/14 days off, on a 28-day cycle of galunisertib for all ongoing trials. Galunisertib is being investigated either as monotherapy or in combination with standard antitumor regimens (including nivolumab

  20. Mothers as informal science class teachers

    Science.gov (United States)

    Katz, Phyllis

    This study explores the participation of mothers as teachers (termed "Adult Leaders") in the Hands On Science Outreach (HOSO) informal science program for pre-kindergarten through sixth grade children. Since women continue to be underrepresented in the sciences (AAUW, 1992; AAUW 1998), there is a need to probe the nature of mothers' choices in science experiences, in the family context, and as role models. Mothers of school age children who choose to lead informal science activities are in a position to teach and learn not only within this alternative setting, but within their homes where values, attitudes, beliefs and motivations are continually cultivated by daily choices (Gordon, 1972; Tamir, 1990; Gerber, 1997). Policy makers recognize that schools are only one environment from many for learning science (National Science Board, 1983; National Research Council, 1996). Using complementary methodology, this study was conducted in two HOSO sessions that extended over six months. Twelve mothers who were HOSO teachers were case study participants. Primary data collection strategies were interviews, journals, and "draw-a-scientist." A larger sample of HOSO mother-teachers (N = 112) also contributed to a surrey, developed from an analysis of the case studies. Informal learning settings must, by their non-compulsory nature, focus on the affective component of learning as a necessity of participation. The framework for the qualitative analysis was from the affective characteristics described by Simpson et al. (1994). The interpretation is informed by sociobiology, science education and adult education theories. The study finds that the twelve mothers began their HOSO teaching believing in science as a way of knowing and valuing the processes and information from its practice. These women perceive their participation as a likely means to increase the success of their child(ren)'s education and are interested in the potential personal gains of leading an informal science

  1. Comparison of the eight weeks of supplementation Creatine and Glutamine consumption along with resistance exercise on the level of ALP in female mice

    Directory of Open Access Journals (Sweden)

    A eskandari

    2015-11-01

    Full Text Available Background and purpose: in recent years, in order to improve power, speed, the increase in the volume of the musculature, preventing sports injuries and maintain the muscle performance athletes use from different resistance exercises and food supplements. In this regard, present study has been conducted with the aim of comparison the influence of an 8 week period consumption of creatine (2 gr.kg-1.day-1 in 1st week and 0.48 gr.kg-1.day-1during 2nd to 8th weeks and glutamine (1 gr.kg-1.day-1 from first to eighth weeks along with resistance exercise on level of ALP of female mice. Materials and methods: This experimental study was done on 80 Small adult female mice of Surrey species (28 ± 5 gram. The animals were randomly divided into 8 groups of: resistance exercise, resistance exercise + creatine, resistance exercise + glutamine, resistance exercise + glutamine + creatine, creatine, glutamine, creatine + glutamine and control groups (N= 10. Resistance exercise (5 days a week was including: climbing (4 sets, 5 times repetition with two minutes rest between the sets from a ladder (with the height of one meter and including 26 steps and bearing 30 percent of the weight of the Mouse body (hanging from tail in the first week and the increasing it up to 200 percent of body weight till the last week of the experiment. During 48 hours after the last practice session of resistance exercise, the blood sample was taken and the the level of ALP has been measured. Findings:The results showed that the level of ALP enzyme in creatine + glutamine + resistance exercise groug had been increased in comparison with the control group (144.3 ± 15.86 in comparison with 234.7 ± 25.69 U.L-1 P < 0.05. Conclusion: The results of this research indicate Creatine and Glutamine supplementation consumption along with resistance exercise increases in the level of ALP enzyme in the liver of mice.

  2. The weeping cow: impact of countermeasures on daily life in Chernobyl contaminated regions

    International Nuclear Information System (INIS)

    Mays, C.; Avetova, E.; Murphy, M.; Allen, P.

    1998-01-01

    Twelve years after the Chernobyl catastrophe, what is the daily life of rural dwellers in contaminated regions of Belarus and the Ukraine? Over the years, protective countermeasures have been applied or withdrawn, and radiation protection advice is still in effect concerning e.g. the consumption of milk or of forest food products. How is that advice regarded by villagers? To what extent do they comply or not comply, and what is their reasoning? How are countermeasures woven into the fabric of social life? In the goal of optimisation, radiation protection countermeasures may be evaluated as the sum of individual dose averted, cost, and distress. A detailed formula exists for calculating dose, but social and economic costs, and individual distress, are in need of modelling.. Twelve focus groups (10 in Belarus, 2 in Ukraine; six groups each of men or of women) were consulted in an effort to develop a convincing and workable definition of distress experienced by members of the rural communities affected by Chernobyl. Stresses introduced by countermeasures, or linked to other aspects of the post-accidental situation, were identified. A systematic content analysis was carried out, bearing on the benefits or satisfactions linked to focus behaviours (e.g, milk consumption, forest visits...), distress experienced, attitudes towards countermeasures, impacts and management of information, etc. The focus group transcripts contain telling, humorous or poignant representations of how people carry on living in the face of threat, uncertainty, and absurdity. This presentation explores social representations of milk, and some of the reported impacts in the Belarus settlements of the post-accident restrictions on milk production and consumption. SPARPA or Social psychological aspects of radiation protection after accidents, is a European Commission part-funded project (F14C-CT96-0010) involving U. Surrey European Institute of Health an Medical Science, Symlog, and UK National

  3. Assessment of vitamin D levels in newly diagnosed children with type 1 diabetes mellitus comparing two methods of measurement: a facility's experience in the Middle Eastern country of Bahrain

    Directory of Open Access Journals (Sweden)

    Al-Haddad FA

    2016-01-01

    Full Text Available Fatima Ahmed Al-Haddad,1 Mansoor H Rajab,2 S Mahmood Al-Qallaf,3 Abdulrahman O Musaiger,4 Kathryn H Hart5 1Dietetic Unit for Hospitals, 2Pediatric Endocrine and Diabetes Team, Pediatric Department, Salmaniya Medical Complex, 3Pharmacy Program, College of Health Sciences, University of Bahrain, Manama, 4Nutrition and Health Studies Unit Deanship of Scientific Research, University of Bahrain, Sakheer, Kingdom of Bahrain; 5School of Biosciences and Medicine, Department of Nutritional Sciences, University of Surrey, Guildford, UK Background: The number of children being diagnosed with type 1 diabetes mellitus (T1DM is on the rise and has more than doubled in the past 10 years in Bahrain. Some studies have linked low vitamin D levels with an increased risk of diabetes. There are concerns regarding the variations in circulating 25(OHD levels measured by different laboratories and by using different analytical techniques. Objective: The aim of this study was to evaluate the vitamin D levels of newly diagnosed children with T1DM using the “gold standard method” with high-pressure liquid chromatography–tandem mass spectrometry methods compared to the chemiluminescence micro-particle immunoassay (CMIA used in a hospital laboratory. Subjects: Eighteen children, aged 6–12 years, who received a confirmed diagnosis of T1DM in 2014 were chosen as subjects. Methods: Serum vitamin D levels were assessed in a hospital, while an extra aliquot of blood collected during routine blood collection after acquiring informed written consents from the subjects, and sent to Princess Al-Jawhara Center for Molecular Medicine and Inherited Disorders to be analyzed by ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS. Results: The mean age of the study group was 9±2 years. The mean total of 25(OHD levels (D3 and D2 assessed by UPLC-MS/MS was 49.7±18.8, whereas the mean total of 25(OHD levels obtained from the CMIA assay was 44.60±13

  4. A bespoke mobile application for the longitudinal assessment of depression and mood during pregnancy: protocol of a feasibility study.

    Science.gov (United States)

    Marcano Belisario, Jose Salvador; Doherty, Kevin; O'Donoghue, John; Ramchandani, Paul; Majeed, Azeem; Doherty, Gavin; Morrison, Cecily; Car, Josip

    2017-05-29

    Depression is a common mental health disorder during pregnancy, with important consequences for mothers and their children. Despite this, it goes undiagnosed and untreated in many women attending antenatal care. Smartphones could help support the prompt identification of antenatal depression in this setting. In addition, these devices enable the implementation of ecological momentary assessment techniques, which could be used to assess how mood is experienced during pregnancy. With this study, we will assess the feasibility of using a bespoke mobile application (app) running on participants' own handsets for the longitudinal (6 months) monitoring of antenatal mood and screening of depression. We will use a randomised controlled study design to compare two types of assessment strategies: retrospective + momentary (consisting of the Edinburgh Postnatal Depression Scale plus five momentary and two contextual questions), and retrospective (consisting of the Edinburgh Postnatal Depression Scale only). We will assess the impact that these strategies have on participant adherence to a prespecified sampling protocol, dropout rates and timeliness of data completion. We will evaluate differences in acceptance of the technology through a short quantitative survey and open-ended questions. We will also assess the potential effect that momentary assessments could have on retrospective data. We will attempt to identify any patterns in app usage through the analysis of log data. This study has been reviewed and approved by the National Research Ethics Service Committee South East Coast-Surrey on 15 April 2016 as a notice of substantial amendment to the original submission (9 July 2015) under the Research Ethics Committee (REC) reference 15/LO/0977. This study is being sponsored by Imperial College London under the reference number 15IC2687 and has been included in the UK Clinical Research Network Study Portfolio under the Central Portfolio Management System number 19280. The

  5. ComPAQS: a compact concentric UV/visible spectrometer, providing a new tool for air quality monitoring from space

    Science.gov (United States)

    Leigh, Roland J.; Whyte, C.; Cutter, M. A.; Lobb, D. R.; Monks, P. S.

    2017-11-01

    Under the first phase of the Centre for Earth Observation Instrumentation (CEOI), a breadboard demonstrator of a novel UV/VIS spectrometer has been developed. Using designs from Surrey Satellite Technology Ltd (SSTL) the demonstrator has been constructed and tested at the University of Leicester's Space Research Centre. This spectrometer provides an exceptionally compact instrument for differential optical absorption spectroscopy (DOAS) applications from LEO, GEO, HAP or ground-based platforms. Measurement of atmo spheric compounds with climate change or air quality implications is a key driver for the ground and space-based Earth Observation communities. Techniques using UV/VIS spectroscopy such as DOAS provide measurements of ozone profiles, aerosol optical depth, certain Volatile Organic Compounds, halogenated species, and key air quality parameters including tropospheric nitrogen dioxide. Compact instruments providing the necessary optical performance and spectral resolution are therefore a key enabling technology. The Compact Air Quality Spectrometer (CompAQS) features a concentric arrangement of a spherical meniscus lens, a concave spherical mirror and a suitable curved diffraction grating. This compact design provides efficiency and performance benefits over traditional concepts, improving the precision and spatial resolution available from space borne instruments with limited weight and size budgets. The breadboard spectrometer currently operating at the University of Leicester offers high throughput with a spectral range from 310 to 450 nm at 0.5nm(UV) to 1.0nm (visible) resolution, suitable for DOAS applications. The concentric design is capable of handling high relative apertures, owing to spherical aberration and coma being near zero at all surfaces. The design also provides correction for transverse chromatic aberration and distortion, in addition to correcting for the distortion called `smile' - the curvature of the slit image formed at each

  6. Patient and parent preferences for characteristics of prophylactic treatment in hemophilia

    Directory of Open Access Journals (Sweden)

    Furlan R

    2015-11-01

    Full Text Available Roberto Furlan,1 Sangeeta Krishnan,2 Jeffrey Vietri3 1Advanced Methods, Kantar Health, Epsom, Surrey, UK; 2Global Health Economics and Outcomes Research, Biogen, MA, USA; 3Health Outcomes, Kantar Health, Milan, Italy Introduction: New longer-acting factor products will potentially allow for less frequent infusion in prophylactic treatment of hemophilia. However, the role of administration frequency relative to other treatment attributes in determining preferences for prophylactic hemophilia treatment regimens is not well understood. Aim: To identify the relative importance of frequency of administration, efficacy, and other treatment characteristics among candidates for prophylactic treatment for hemophilia A and B. Method: An Internet survey was conducted among hemophilia patients and the parents of pediatric hemophilia patients in Australia, Canada, and the US. A monadic conjoint task was included in the survey, which varied frequency of administration (three, two, or one time per week for hemophilia A; twice weekly, weekly, or biweekly for hemophilia B, efficacy (no bleeding or breakthrough bleeding once every 4 months, 6 months, or 12 months, diluent volume (3 mL vs 2.5 mL for hemophilia A; 5 mL vs 3 mL for hemophilia B, vials per infusion (2 vs 1, reconstitution device (assembly required vs not, and manufacturer (established in hemophilia vs not. Respondents were asked their likelihood to switch from their current regimen to the presented treatment. Respondents were told to assume that other aspects of treatment, such as risk of inhibitor development, cost, and method of distribution, would remain the same. Results: A total of 89 patients and/or parents of children with hemophilia A participated; another 32 were included in the exercise for hemophilia B. Relative importance was 47%, 24%, and 18% for frequency of administration, efficacy, and manufacturer, respectively, in hemophilia A; analogous values were 48%, 26%, and 21% in

  7. 'You can't be a person and a doctor': the work-life balance of doctors in training-a qualitative study.

    Science.gov (United States)

    Rich, Antonia; Viney, Rowena; Needleman, Sarah; Griffin, Ann; Woolf, Katherine

    2016-12-02

    Investigate the work-life balance of doctors in training in the UK from the perspectives of trainers and trainees. Qualitative semistructured focus groups and interviews with trainees and trainers. Postgraduate medical training in London, Yorkshire and Humber, Kent, Surrey and Sussex, and Wales during the junior doctor contract dispute at the end of 2015. Part of a larger General Medical Council study about the fairness of postgraduate medical training. 96 trainees and 41 trainers. Trainees comprised UK graduates and International Medical Graduates, across all stages of training in 6 specialties (General Practice, Medicine, Obstetrics and Gynaecology, Psychiatry, Radiology, Surgery) and Foundation. Postgraduate training was characterised by work-life imbalance. Long hours at work were typically supplemented with revision and completion of the e-portfolio. Trainees regularly moved workplaces which could disrupt their personal lives and sometimes led to separation from friends and family. This made it challenging to cope with personal pressures, the stresses of which could then impinge on learning and training, while also leaving trainees with a lack of social support outside work to buffer against the considerable stresses of training. Low morale and harm to well-being resulted in some trainees feeling dehumanised. Work-life imbalance was particularly severe for those with children and especially women who faced a lack of less-than-full-time positions and discriminatory attitudes. Female trainees frequently talked about having to choose a specialty they felt was more conducive to a work-life balance such as General Practice. The proposed junior doctor contract was felt to exacerbate existing problems. A lack of work-life balance in postgraduate medical training negatively impacted on trainees' learning and well-being. Women with children were particularly affected, suggesting this group would benefit the greatest from changes to improve the work-life balance of

  8. The effectiveness of behavioural interventions in the primary prevention of Hepatitis C amongst injecting drug users: a randomised controlled trial and lessons learned

    Directory of Open Access Journals (Sweden)

    Tibbs Christopher

    2008-07-01

    Full Text Available Abstract Aim To develop and evaluate the comparative effectiveness of behavioural interventions of enhanced prevention counselling (EPC and simple educational counselling (SEC in reducing hepatitis C viral (HCV infection in sero-negative injecting drug users (IDU. Design Randomised controlled trial (RCT of EPC intervention in comparison with simple educational counselling (SEC. Setting Specialised Drug services in London and Surrey, United Kingdom. Participants and Measurements Ninety five IDUs were recruited and randomised to receive EPC (n = 43 or SEC (n = 52. Subjects were assessed at baseline using the Addiction Severity Index (ASI, the Injecting Risk Questionnaire (IRQ, and Drug Injecting Confidence Questionnaire (DICQ. The primary outcome was measured by the rate of sero-conversion at 6 months and 12 months from baseline and by the ASI, IRQ and DICQ at 6 months from baseline. Hepatitis C testing was undertaken by the innovative test of the dried blood spot (DBS test which increased the rate of testing by 4 fold compared to routine blood testing. Findings Seventy Eighty two subjects (82% out of the 95 recruited were followed up at 6 months and 62 (65% were followed up at 12 months. On the primary outcome measure of the rate of seroconversion, 8 out of 62 patients followed-up at twelve months seroconverted, three in the EPC group and five in the SEC group, indicating incidence rates of 9.1 per 100 person years for the EPC group, 17.2 per 100 person years for the SEC group, and 12.9 per 100 person years for the cohort as a whole. Analysis of the secondary outcome measures on alcohol use, risk behaviour, psychological measures, quality of life, showed no significant differences between the EPC and the SEC groups. However, there were significant changes on a number of measures from baseline values indicating positive change for both groups. Conclusion We were not able to prove the efficacy of EPC in comparison with SEC in the prevention of

  9. Skin acceptability of a cosmetic moisturizer formulation in female subjects with sensitive skin

    Directory of Open Access Journals (Sweden)

    Nisbet SJ

    2018-04-01

    Full Text Available Stephanie J Nisbet Skin Health Medical Affairs, GSK Consumer Healthcare, Weybridge, Surrey, UK Purpose: This 3-week, open-label, noncomparative clinical study evaluated the skin acceptability of a cosmetic moisturizer in subjects with sensitive skin, by monitoring adverse events (AEs and cutaneous discomfort related to normal usage.Materials and methods: Female subjects aged between 18–60 years, with Fitzpatrick phototype classification I–IV and sensitive skin, verified by a positive reaction on the stinging test at screening, were included. Subjects applied the moisturizer to their face and body twice daily for 21±2 days at home and recorded study product usage and feelings of cutaneous discomfort (eg, dryness, prickling, stinging, and itching in a diary; any AEs were reported to the clinic. At study end, skin acceptability of the moisturizer was investigator-assessed based on the nature of AEs and subjects’ self-reported feelings of discomfort, and by clinical evaluation of skin reactions in the area of moisturizer application (appearance of erythema, formation of edema, and skin desquamation; scored according to an adapted Draize and Kligman scale. Only subjects with a treatment compliance of ≥80% were included in the final analysis.Results: In total, 35 subjects initiated and completed the study; all were compliant to the minimum study product usage. Per investigator clinical dermatological assessment at study end, none of the 35 subjects had skin reactions in the area of moisturizer application and there were no reported AEs. One subject reported sensations of mild prickling and itching immediately after applying the moisturizer (not classified as AEs, which spontaneously remitted after complete absorption of the product and were noted only in exposed areas. These events were considered by the investigator as being possibly/probably related to the use of study product; however, no clinical signs of skin reaction were observed in

  10. Health care costs before and after diagnosis of depression in patients with unexplained pain: a retrospective cohort study using the United Kingdom General Practice Research Database

    Directory of Open Access Journals (Sweden)

    Reed C

    2013-01-01

    Full Text Available Catherine Reed,1 Jihyung Hong,2 Diego Novick,1 Alan Lenox-Smith,3 Michael Happich41Global Health Outcomes, Eli Lilly and Company, Windlesham, Surrey, UK; 2Personal Social Services Research Unit, London School of Economics and Political Science, London, UK; 3Eli Lilly UK, Basingstoke, UK; 4Eli Lilly and Company, Bad Homburg, GermanyPurpose: To assess the impact of pain severity and time to diagnosis of depression on health care costs for primary care patients with pre-existing unexplained pain symptoms who subsequently received a diagnosis of depression.Patients and methods: This retrospective cohort study analyzed 4000 adults with unexplained pain (defined as painful physical symptoms [PPS] without any probable organic cause and a subsequent diagnosis of depression, identified from the UK General Practice Research Database using diagnostic codes. Patients were categorized into four groups based on pain severity (milder or more severe; based on number of pain-relief medications and use of opioids and time to diagnosis of depression (≤1 year or >1 year from PPS index date. Annual health care costs were calculated (2009 values and included general practitioner (GP consultations, secondary care referrals, and prescriptions for pain-relief medications for the 12 months before depression diagnosis and in the subsequent 2 years. Multivariate models of cost included time period as a main independent variable, and adjusted for age, gender, and comorbidities.Results: Total annual health care costs before and after depression diagnosis for the four patient groups were higher for the groups with more severe pain (£819–£988 versus £565–£628; P < 0.001 for all pairwise comparisons and highest for the group with more severe pain and longer time to depression diagnosis in the subsequent 2 years (P < 0.05. Total GP costs were highest in the group with more severe pain and longer time to depression diagnosis both before and after depression diagnosis (P

  11. Sex differences in the course of schizophrenia across diverse regions of the world

    Directory of Open Access Journals (Sweden)

    Novick D

    2016-11-01

    Full Text Available Diego Novick,1 William Montgomery,2 Tamas Treuer,3 Maria Victoria Moneta,4 Josep Maria Haro4 1Eli Lilly and Company, Windlesham, Surrey, UK; 2Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 3Eli Lilly and Company, Neuroscience Research, Budapest, Hungary; 4Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain Abstract: This study explores sex differences in the outcomes of patients with schizophrenia (clinical/functional remission and recovery across diverse regions of the world (Northern Europe, Southern Europe, Central and Eastern Europe, Latin America, East Asia, and North Africa and the Middle East. Data (n=16,380 for this post hoc analysis were taken from the World-Schizophrenia Health Outcomes Study. In most regions, females had a later age at first service contact for schizophrenia, a lower level of overall/negative symptom severity, lower rates of alcohol/substance abuse and paid employment, and higher percentages of having a spouse/partner and independent living. Overall, females had slightly higher rates of clinical remission (58.0% vs 51.8%, functional remission (22.8% vs 16.0%, and recovery (16.5% vs 16.0% at 36 months (P<0.001 for all. This pattern was consistently observed in Southern Europe and Northern Europe even after controlling for baseline sex differences, but not in other regions. In Central and Eastern Europe, rates of clinical remission were higher in females at 36 months, but those of functional remission and recovery were similar between males and females. The opposite was observed for Latin America. In East Asia, sex differences were rarely observed for these outcomes. Finally, in North Africa and the Middle East, sex differences in these outcomes were pronounced only in regression analyses. These regional variations shed light on the importance of psychosocial and cultural factors and their effects on sex in the prognosis of schizophrenia. Keywords: sex, remission, recovery

  12. Cibola flight experiment satellite

    Science.gov (United States)

    Davies, P.; Liddle, Doug; Paffett, John; Sweeting, Martin; Curiel, A.; Sun, Wei; Eves, Stuart

    2004-11-01

    In order to achieve an "economy of scale" with respect to payload capacity the major trend in telecommunications satellites is for larger and larger platforms. With these large platforms the level of integration between platform and payload is increasing leading to longer delivery schedules. The typical lifecycle for procurement of these large telecommunications satellites is now 3-6 years depending on the level of non-recurring engineering needed. Surrey Satellite Technology Ltd (SSTL) has designed a low-cost platform aimed at telecommunications and navigation applications. SSTL's Geostationary Minisatellite Platform (GMP) is a new entrant addressing the lower end of the market with payloads up to 250kg requiring less than 1.5 kW power. The British National Space Centre through the MOSAIC Small Satellite Initiative supported the development of GMP. The main design goals for GMP are low-cost for the complete mission including launch and operations and a platform allowing flexible payload accommodation. GMP is specifically designed to allow rapid development and deployment with schedules typically between 1 and 2 years from contract signature to flight readiness. GMP achieves these aims by a modular design where the level of integration between the platform and payload is low. The modular design decomposes the satellite into three major components - the propulsion bay, the avionics bay and the payload module. Both the propulsion and avionics bays are reusable, largely unchanged, and independent of the payload configuration. Such a design means that SSTL or a 3rd party manufacturer can manufacture the payload in parallel to the platform with integration taking place quite late in the schedule. In July 2003 SSTL signed a contract for ESA's first Galileo navigation satellite known as GSTBV2/A. The satellite is based on GMP and ESA plan to launch it into a MEO orbit late in 2005. The second flight of GMP is likely to be in 2006 carrying a geostationary payload

  13. Health-related quality of life, visual function and treatment satisfaction following intravitreal dexamethasone implant for diabetic macular edema

    Directory of Open Access Journals (Sweden)

    Ramu J

    2017-03-01

    Full Text Available Jayashree Ramu,1 Irini Chatziralli,1 Yit Yang,2 Geeta Menon,3 Clare Bailey,4 Michael Eckstein,5 Phil Hykin,1 Sobha Sivaprasad1 On behalf of the OZDRY Study Group 1NIHR Moorfields Biomedical Research Centre, London, 2The Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, 3Frimley Health NHS Foundation Trust, Surrey, 4Bristol Eye Hospital, Bristol, 5Brighton and Sussex University Hospital, Brighton, UK Purpose: The aim of this study was to explore and describe quantitatively patient-reported outcome measures (PROMs, ie, health-related quality of life (QoL, visual function and treatment satisfaction, in patients with diabetic macular edema (DME receiving two different regimens of Ozurdex (intravitreal dexamethasone implant. Methods: In this multicenter, prospective study, 100 patients with center-involving refractory DME were randomized 1:1 to either five monthly fixed dosing or optical coherence tomography (OCT-guided pro re nata (PRN regimen of dexamethasone intravitreal implant therapy. The primary outcome was the difference between arms in change in PROMs and health-related QoL from baseline to 12 months, as measured by the Retinopathy-Dependent Quality of Life (RetDQoL questionnaire, Visual Function Questionnaire-25 (VFQ-25 and Retinopathy Treatment Satisfaction Questionnaire (RetTSQ. Results: There was no statistically significant difference in the RetDQoL score and VFQ-25 score at month 12 compared to those at baseline, whereas the total mean RetTSQ score increased significantly at the exit visit. The two treatment arms did not differ significantly regarding the change in PROMs and health-related QoL questionnaires. Logistic regression analysis showed that visual acuity (VA of ≥55 letters, central foveal thickness <300 µm and macular volume <9.2 mm3 at the exit visit (month 12 predicted a higher change in RetTSQ. Conclusion: This study showed that there is a statistically significant improvement in treatment satisfaction, as

  14. Long-term functional improvements in the 2-year treatment of schizophrenia outpatients with olanzapine long-acting injection

    Directory of Open Access Journals (Sweden)

    Ascher-Svanum H

    2014-06-01

    Full Text Available Haya Ascher-Svanum,1 Diego Novick,2,3 Josep Maria Haro,4 Jordan Bertsch,4 David McDonnell,1 Holland Detke11Eli Lilly and Company, Indianapolis, IN, USA; 2Eli Lilly and Company, Windlesham, Surrey, UK; 3Departament de Psiquiatria, Universitat Autonoma de Barcelona, Spain; 4Parc Sanitari Sant Joan de Déu, Centro de Investigación Biomédica en Red en el Área de Salud Mental, Universitat de Barcelona, Barcelona, SpainBackground: Little is known about the long-term changes in the functioning of schizophrenia patients receiving maintenance therapy with olanzapine long-acting injection (LAI, and whether observed changes differ from those seen with oral olanzapine.Methods: This study describes changes in the levels of functioning among outpatients with schizophrenia treated with olanzapine-LAI compared with oral olanzapine over 2 years. This was a secondary analysis of data from a multicenter, randomized, open-label, 2-year study comparing the long-term treatment effectiveness of monthly olanzapine-LAI (405 mg/4 weeks; n=264 with daily oral olanzapine (10 mg/day; n=260. Levels of functioning were assessed with the Heinrichs–Carpenter Quality of Life Scale. Functional status was also classified as “good”, “moderate”, or “poor”, using a previous data-driven approach. Changes in functional levels were assessed with McNemar’s test and comparisons between olanzapine-LAI and oral olanzapine employed the Student’s t-test. Results: Over the 2-year study, the patients treated with olanzapine-LAI improved their level of functioning (per Quality of Life total score from 64.0–70.8 (P<0.001. Patients on oral ­olanzapine also increased their level of functioning from 62.1–70.1 (P<0.001. At baseline, 19.2% of the olanzapine-LAI-treated patients had a “good” level of functioning, which increased to 27.5% (P<0.05. The figures for oral olanzapine were 14.2% and 24.5%, respectively (P<0.001. Results did not significantly differ between

  15. Relation of NDVI obtained from different remote sensing at different space and resolutions sensors in Spanish Dehesas

    Science.gov (United States)

    Escribano Rodríguez, Juan; Tarquis, Ana M.; Saa-Requejo, Antonio; Díaz-Ambrona, Carlos G. H.

    2015-04-01

    Satellite data are an important source of information and serve as monitoring crops on large scales. There are several indexes, but the most used for monitoring vegetation is NDVI (Normalized Difference Vegetation Index), calculated from the spectral bands of red (RED) and near infrared (NIR), obtaining the value according to relationship: [(NIR - RED) / (NIR + RED)]. During the years 2010-2013 monthly monitoring was conducted in three areas of Spain (Salamanca, Caceres and Cordoba). Pasture plots were selected and satellite images of two different sensors, DEIMOS-1 and MODIS were obtained. DEIMOS-1 is based on the concept Microsat-100 from Surrey. It is designed for imaging the Earth with a resolution good enough to study terrestrial vegetation cover (20x20 m), although with a wide range of visual field (600 km) to get those images with high temporal resolution. By contrast, MODIS images present a much lower spatial resolution (500x500 m). Indices obtained from both sensors to the same area and date are compared and the results show r2 = 0.56; r2 = 0.65 and r2 = 0.90 for the areas of Salamanca, Cáceres and Cordoba respectively. According to the results obtained show that the NDVI obtained by MODIS is slightly larger than that obtained by the sensor for DEIMOS for same time and area. References J.A. Escribano, C.G.H. Diaz-Ambrona, L. Recuero, M. Huesca, V. Cicuendez, A. Palacios-Orueta y A.M. Tarquis. Aplicacion de Indices de Vegetacion para evaluar la falta de produccion de pastos y montaneras en dehesas. I Congreso Iberico de la Dehesa y el Montado. 6-7 Noviembre, 2013, Badajoz. J.A. Escribano Rodriguez, A.M. Tarquis, C.G. Hernandez Diaz-Ambrona. Pasture Drought Insurance Based on NDVI and SAVI. Geophysical Research Abstracts, 14, EGU2012-13945, 2012. EGU General Assembly 2012. Juan Escribano Rodriguez, Carmelo Alonso, Ana Maria Tarquis, Rosa Maria Benito, Carlos Hernandez Diaz-Ambrona. Comparison of NDVI fields obtained from different remote sensors

  16. Soil weed seed bank in situ and ex situ at a smallholder field in Maranhão State, northeastern Brazil

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    Mário Luiz Ribeiro Mesquita

    2014-11-01

    Full Text Available The objective of this research was to assess the density, floristic composition,  phytosociology and diversity of a soil weed seed bank ex situ by germination in a greenhouse and in situ by weed sampling on a smallholder corn field located in Lago Verde County, Maranhão State. Fifteen pairs of 25 m2 plots were designated. In half of these plots, 90 soil samples were collected with an open metal template measuring 25 x 16 x 3 cm and placed in a greenhouse to germinate. In the other half, 90 weed samples were collected using the same metal template. We recorded a total of 1,998 individuals from 40 species, 31 genera and 16 families, from which 659 individuals germinated in situ and 1,339 exsitu. Density was higher ex situ, with 372 plants m-2. The Cyperaceae family had the highest floristic richness with nine species, followed by the Poaceae with six. The dominant species based on the Importance Value Index were Lindernia crustacea (IVI 27.7% in situ and Scleria lithosperma (IVI 37.0% ex situ. Floristic diversity was higher ex situ, with H’ = 2.66 nats ind-1. These results could help predict infestation potential and could lead to improved weed management strategies in corn-growing areas on smallholdings in Maranhão State, northeastern Brazil.

  17. Book Reviews

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    Chanatip Kesavadhana

    2000-01-01

    Full Text Available - A.S. Baer, Philip Houghton, People of the Great Ocean; Aspects of human biology of the early Pacific. Cambridge: Cambridge University Press, 1996, x + 292 pp. - Greg Bankoff, Vicente L. Rafael, Figures of criminality in Indonesia, the Philippines, and colonial Vietnam. Ithaca, NY: Cornell University Southeast Asis Program, 1999, 258 pp. - Harold Brookfield, Donald Denoon, The Cambridge history of the Pacific Islanders. Cambridge: Cambridge University Press, 1997, xvi + 518 pp., Stewart Firth, Jocelyn Linnekin (eds. - Cynthia Chou, Shoma Munshi, Clifford Sather, The Bajau Laut; Adaptation, history, and fate in a maritime fishing society of south-eastern Sabah. Kuala Lumpur: Oxford University Press, 1997, xviii + 359 pp. - Cynthia Chou, Shoma Munshi, Krishna Sen, Gender and power in affluent Asia. London: Routledge, 1998, xiii + 323 pp., Maila Stivens (eds. - Freek Colombijn, Arne Kalland, Environmental movements in Asia. Richmond, Surrey: Curzon, 1998, xiii + 296 pp. [Nordic Institute of Asian Studies, Man and Nature in Asia Series 4.], Gerard Persoon (eds. - Kirsten W. Endres, Phan Huy Chu, Hai trinh chi luoc; Récit sommaire d’un voyage en mer (1833; Un émissaire Vietnamien à Batavia. Paris: EHESS, 1994, viii + 228 pp. [Cahier d’Archipel 25.] - Aone van Engelenhoven, Veronica Du Feu, Rapanui. London: Routledge, 1996, xv + 217 pp. [Routledge Descriptive Grammars.] - Fukui Hayao, Peter Boomgard, Paper landscapes; Explorations in the environmental history of Indonesia, 1997, vi + 424 pp. Leiden: KITLV Press. [Verhandelingen 178.], Freek Colombijn, David Henley (eds. - Volker Heeschen, J. Miedema, Texts from the oral tradition in the south-western Bird’s Head Peninsula of Irian Jaya; Teminabuan and hinterland. Leiden: DSALCUL, Jakarta: ISIR, 1995, vi + 98 pp. [Irian Jaya Source Materials 14.] - Volker Heeschen, J. Miedema, Texts from the oral tradition in the southern Bird’s Head Peninsula of Irian Jaya; Inanwatan-Berau, Arandai

  18. 20 Years Experience with using Low Cost Launch Opportunities for 20 Small Satellite Missions

    Science.gov (United States)

    Meerman, Maarten; Sweeting, Martin, , Sir

    these larger 'small satellites' are too big to be carried 'piggy-back'. The entrepreneurial efforts of leading FSU rocket &missile organisations in converting existing vehicles to meet the small satellite launch market at an appropriate cost has resulted in the FSU now holding the prime position for providing launches for the small satellite community - and with an excellent track record of successful launches. However, negotiating and completing a Launch Services Agreement (LSA) for a nano-micro-minisatellite with any launcher organisation is a complex matter and risky territory for the unwary or inexperienced who may easily fall prey to unexpected additional costs and delays. Whilst this warning should be heeded when dealing with European and US organisations, it is particularly relevant when negotiating launches from the FSU where there is a plethora of agencies and organisations offering a bewildering range of launch vehicles and options. Furthermore, the FSU has developed a very different technical and managerial philosophy towards launchers when compared with the west and this can be unnerving to 'first-time buyers'. Organisations experienced in dealing in the FSU will encounter a different but excellent service - once the launch service agreement has been thoroughly and fiercely negotiated in every detail. The inexperienced, however, have encountered frustrating delays, lost opportunities, unexpected taxes and costs for additional services or facilities not originally specified, and bewilderment at the different procedures used in the FSU. Fortunately, all this can be avoided with proper experience and the FSU is the current mainstay for launching small satellites quickly, affordably and reliably. Surrey has unique experience gathered over 20 years in handling launches for 20 small satellites, ranging from a 6kg nanosatellite, 50-100kg microsatellites, and a 325kg minisatellite, using 7 different launchers from the USA, Russia, Ukraine, and Europe. By working

  19. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2003-01-01

    + 241 pp. [BRC Occasional paper 1.] -Gerrit Knaap, Frédéric Mantienne, Les relations politiques et commerciales entre la France et la péninsule Indochinoise (XVIIe siècle. Paris: Les Indes Savantes, 2001, 395 pp. -Uli Kozok, James T. Collins, Malay, world language; A short history. Second edition. Kuala Lumpur: Dewan bahasa dan pustaka, 2000, xii + 101 pp. -Nathan Porath, Hoe Ban Seng, Semalai communities at Tasek Bera; A study of the structure of an Orang Asli society. [A.S. Baer and R. Gianno, eds.] Subang Jaya, Malaysia: Centre for Orang Asli concerns, 2001, xii + 191 pp. -Nathan Porath, Narifumi Maeda Tachimoto, The Orang Hulu; A report on Malaysian orang asli in the 1960's. [A.S. Baer, ed.] Subang Jaya, Malaysia: Centre for Orang Asli concerns, 2001, xiv + 104 pp. -Martin Ramstedt, Raechelle Rubinstein ,Staying local in the global village; Bali in the twentieth century. Honolulu: University of Hawai'i Press, 1999, xiii + 353 pp., Linda H. Connor (eds -Albert M. Salamanca, Thomas R. Leinbach ,Southeast Asia: diversity and development. Upper Saddle River, NJ: Prentice Hall, 2000, xiii + 594 pp., Richard Ulack (eds -Heather Sutherland, Muhamad Hisyam, Caught between three fires; The Javanese pangulu under the Dutch colonial administration, 1882-1942. Jakarta: Indonesian-Netherlands cooperation in Islamic studies (INIS, 2001, 331 pp. [Seri INIS 37.] -Heather Sutherland, Roderich Ptak, China's seaborne trade with South and Southeast Asia (1200-1750. Aldershot: Ashgate, 1999, xii + 366 pp. [Variorum collected studies series CS638.] -Sikko Visscher, M. Jocelyn Armstrong ,Chinese populations in contemporary Southeast Asian societies. Richmond, Surrey: Curzon, 2001, xiv + 268 pp., R. Warwick Armstrong, Kent Mulliner (eds -Reed Wadley, Clifford Sather, Seeds of play, words of power; An ethnographic study of Iban shamanic chants. Kuching: Tun Jugah foundation, 2001, xvii + 753 pp. [Borneo classic series 5.] -Boris Wastiau, Raymond Corbey, Tribal art traffic; A chronicle

  20. Self-consistent solution for a collisionless plasma slab in motion across a magnetic field

    International Nuclear Information System (INIS)

    Echim, Marius M.; Lemaire, Joseph F.; Roth, Michel

    2005-01-01

    The problem of the dynamics of a plasma slab moving across a magnetic field is treated in the framework of the kinetic theory. A velocity distribution function (VDF) is found for each plasma species, electrons and protons, in terms of the constants of motion defined by the geometry of the problem. The zero- and first-order moments of the VDF are introduced into the right-hand side term of Maxwell's equations to compute the electric and magnetic vector potentials and corresponding fields. The solutions are found numerically. We obtain a region of plasma convection--the slab proper--where the plasma moves with a uniform velocity, V x =V 0 =(ExB/B 2 ) x . At the core margins two plasma 'wings' are formed, each being the result of a pair of interpenetrated boundary layers with different transition lengths. Inside these wings, the plasma velocity is not uniform, V x ≠(ExB/B 2 ) x . It decreases from the maximum value obtained in the core to a minimum value in the central region of the wings where a flow reversal is found with the plasma convecting in the opposite direction to the core motion. There is also an asymmetry of the velocity gradient at the borders of the core, which results in a corresponding asymmetry in the thickness of the wings. Furthermore, it is found that the reversed plasma flow in the thinner wing is larger than that in the broader wing. For a fixed direction of the magnetic field the two plasma wings interchange position with respect to the center of the slab when the plasma bulk velocity reverses sign

  1. Evaluation of intra-cellular lipid of skeletal muscle by 1H-MR spectroscopy: in vivo and phantom study

    International Nuclear Information System (INIS)

    Ma Ling; Gao Zhenhua; Meng Quanfei; Lin Erjian; Zhang Xiaoling; Deng Demao

    2009-01-01

    Objective: To elucidate the spectrum of lipid peaks in 1 H-MRS of skeletal muscle and it's interpretation, to investigate the utility of 1 H-MRS in evaluating intramyocellular lipid (IMCL). Methods: 1 H-MRS was acquired in vivo on tibialis anterior muscle (TA) and soleus muscle (S) on 5 healthy volunteers. The spectrum of the lipid peak between 0.80 and 1.80 ppm was observed with different angle between the long axis of the calf and B 0 . Ex vivo phantom was an cluster of capillary tubers filled with soybean oil and fat emulsion, simulating the extramyocellular lipid (EMCL) and IMCL, respectively. The spectra of the lipid peaks were compared using different angles between the phantom and Bo field. Results: The lipid spectrum split to 3 to 4 peaks between 0.80 and 1.80 ppm on calf muscles, with 0.20 to 0.30 ppm interval between each neighbouring peak. The methylene peak of EMCL shifted to the right when the angle between long axis of the calf and B 0 increased. The phantom could simulate the spectrum of 1 H-MRS of the muscle, presenting two peaks with 0.20 to 0.30 ppm chemical shift difference between 0.80 and 1.80 ppm. They are methyl triglyceride and methylene, representing IMCL and EMCL, respectively. The peak splitting could be attributed to the high ordered muscle fibers and their chemical shift difference between inta-and extra-cellular distribution. The interval of IMCL and EMCL peaks attenuated when the angle between the muscle fiber and B 0 increased from 0 to the magic angle (54.7 degree). Conclusion: On 1 H- MRS spectrum, the peak of the EMCL and IMCL splits. This indicated that 1 H-MRS is an applicable method to detect IMCL noninvasively. TA is an optimizing muscle for 1 H-MRS study. (authors)

  2. Performance of a new one-step multi-mode adhesive on etched vs non-etched enamel on bond strength and interfacial morphology.

    Science.gov (United States)

    de Goes, Mario Fernando; Shinohara, Mirela Sanae; Freitas, Marcela Santiago

    2014-06-01

    To compare microtensile bond strength (μTBS) and interfacial morphology of a new one-step multimode adhesive with a two-step self-etching adhesive and two etch-and-rinse adhesives systems on enamel. Thirty human third molars were sectioned to obtain two enamel fragments. For μTBS, 48 enamel surfaces were ground using 600-grit SiC paper and randomly assigned into 6 groups (n = 8): nonetched Scotchbond Universal [SBU]; etched SBU [SBU-et]; non-etched Clearfil SE Bond [CSE]; etched CSE [CSE-et]; Scotchbond Multi-PURPOSE [SBMP]; Excite [EX]. The etched specimens were conditioned with 37% phosphoric acid for 30 s, each adhesive system was applied according to manufacturers' instructions, and composite resin blocks (Filtek Supreme Plus, 3M ESPE) were incrementally built up. Specimens were sectioned into beams with a cross-sectional area of 0.8-mm2 and tested under tension (1 mm/min). The data were analyzed with oneway ANOVA and Fisher's PLSD (α = 0.05). For interface analysis, two samples from each group were embedded in epoxy resin, polished, and then observed using scanning electron microscopy (SEM). The μTBS values (in MPa) and the standard deviations were: SBU = 27.4 (8.5); SBU-et = 33.6 (9.3); CSE = 28.5 (8.3); CSE-et = 34.2 (9.0); SBMP = 30.4 (11.0); EX = 23.3 (8.2). CSE-et and SBU-et presented the highest bond strength values, followed by SBMP, CSE, and SBU which did not differ significantly from each other. EX showed the statistically significantly lowest bond strength values. SEM images of interfaces from etched samples showed long adhesive-resin tags penetrating into demineralized enamel. Preliminary etching of enamel significantly increased bond strength for the new one-step multimode adhesive SBU and two-step self-etching adhesive CSE.

  3. Population-based study of smoking behaviour throughout pregnancy and adverse perinatal outcomes.

    LENUS (Irish Health Repository)

    Murphy, Deirdre J

    2013-09-01

    There has been limited research addressing whether behavioural change in relation to smoking is maintained throughout pregnancy and the effect on perinatal outcomes. A cohort study addressed lifestyle behaviours of 907 women who booked for antenatal care and delivered in a large urban teaching hospital in 2010-2011. Adverse perinatal outcomes were compared for "non-smokers", "ex-smokers" and "current smokers". Of the 907 women, 270 (30%) reported smoking in the six months prior to pregnancy, and of those 160 (59%) had stopped smoking and 110 (41%) continued to smoke at the time of the first antenatal visit. There was virtually no change in smoking behaviour between the first antenatal visit and the third trimester of pregnancy. Factors associated with continuing to smoke included unplanned pregnancy (OR 1.9; 95% CI 1.3, 2.9), alcohol use (OR 3.4; 95% CI 2.1, 6.0) and previous illicit drug use (OR 3.6; 95% CI 2.1, 6.0). Ex-smokers had similar perinatal outcomes to non-smokers. Current smoking was associated with an average reduction in birth weight of 191 g (95% CI -294, -88) and an increased incidence of intrauterine growth restriction (24% versus 13%, adjusted OR 1.39 (95% CI 1.06, 1.84). Public Health campaigns emphasise the health benefits of quitting smoking in pregnancy. The greatest success appears to be pre-pregnancy and during the first trimester where women are largely self-motivated to quit.

  4. Role of insulin on exercise-induced GLUT-4 protein expression and glycogen supercompensation in rat skeletal muscle.

    Science.gov (United States)

    Kuo, Chia-Hua; Hwang, Hyonson; Lee, Man-Cheong; Castle, Arthur L; Ivy, John L

    2004-02-01

    The purpose of this study was to investigate the role of insulin on skeletal muscle GLUT-4 protein expression and glycogen storage after postexercise carbohydrate supplementation. Male Sprague-Dawley rats were randomly assigned to one of six treatment groups: sedentary control (Con), Con with streptozocin (Stz/C), immediately postexercise (Ex0), Ex0 with Stz (Stz/Ex0), 5-h postexercise (Ex5), and Ex5 with Stz (Stz/Ex5). Rats were exercised by swimming (2 bouts of 3 h) and carbohydrate supplemented immediately after each exercise session by glucose intubation (1 ml of a 50% wt/vol). Stz was administered 72-h before exercise, which resulted in hyperglycemia and elimination of the insulin response to the carbohydrate supplement. GLUT-4 protein of Ex0 rats was 30% above Con in fast-twitch (FT) red and 21% above Con in FT white muscle. In Ex5, GLUT-4 protein was 52% above Con in FT red and 47% above Con in FT white muscle. Muscle glycogen in FT red and white muscle was also increased above Con in Ex5 rats. Neither GLUT-4 protein nor muscle glycogen was increased above Con in Stz/Ex0 or Stz/Ex5 rats. GLUT-4 mRNA in FT red muscle of Ex0 rats was 61% above Con but only 33% above Con in Ex5 rats. GLUT-4 mRNA in FT red muscle of Stz/C and Stz/Ex0 rats was similar but significantly elevated in Ex5/Stz rats. These results suggest that insulin is essential for the increase in GLUT-4 protein expression following postexercise carbohydrate supplementation.

  5. A designated centre for people with disabilities operated by Three Steps, Co. Dublin

    LENUS (Irish Health Repository)

    Murphy, Deirdre J

    2013-09-01

    There has been limited research addressing whether behavioural change in relation to smoking is maintained throughout pregnancy and the effect on perinatal outcomes. A cohort study addressed lifestyle behaviours of 907 women who booked for antenatal care and delivered in a large urban teaching hospital in 2010-2011. Adverse perinatal outcomes were compared for "non-smokers", "ex-smokers" and "current smokers". Of the 907 women, 270 (30%) reported smoking in the six months prior to pregnancy, and of those 160 (59%) had stopped smoking and 110 (41%) continued to smoke at the time of the first antenatal visit. There was virtually no change in smoking behaviour between the first antenatal visit and the third trimester of pregnancy. Factors associated with continuing to smoke included unplanned pregnancy (OR 1.9; 95% CI 1.3, 2.9), alcohol use (OR 3.4; 95% CI 2.1, 6.0) and previous illicit drug use (OR 3.6; 95% CI 2.1, 6.0). Ex-smokers had similar perinatal outcomes to non-smokers. Current smoking was associated with an average reduction in birth weight of 191 g (95% CI -294, -88) and an increased incidence of intrauterine growth restriction (24% versus 13%, adjusted OR 1.39 (95% CI 1.06, 1.84). Public Health campaigns emphasise the health benefits of quitting smoking in pregnancy. The greatest success appears to be pre-pregnancy and during the first trimester where women are largely self-motivated to quit.

  6. Approaches for Making High Performance Polymer Materials from Commodity Polymers

    Institute of Scientific and Technical Information of China (English)

    Xu Xi

    2004-01-01

    A brief surrey of ongoing research work done for improving and enhancing the properties of commodity polymers by the author and author's colleagues is given in this paper. A series of high performance polymers and polymer nanomaterials were successfully prepared through irradiation and stress-induced reactions of polymers and hydrogen bonding. The methods proposed are viable, easy in operation, clean and efficient.1. The effect of irradiation source (UV light, electron beam, γ -ray and microwave), irradiation dose, irradiation time and atmosphere etc. on molecular structure of polyolefine during irradiation was studied. The basic rules of dominating oxidation, degradation and cross-linking reactions were mastered. Under the controlled conditions, cross-linking reactions are prevented, some oxygen containing groups are introduced on the molecular chain of polyolefine to facilitate the interface compatibility of their blends. A series of high performance polymer materials: u-HDPE/PA6,u-HDPE/CaCO3, u-iPP/STC, γ-HDPE/STC, γ-LLDPE/ATH, e-HDPE, e-LLDPE and m-HDPEfilled system were prepared (u- ultraviolet light irradiated, γ- γ-ray irradiated, e- electron beam irradiated, m- microwave irradiated)2. The effect of ultrasonic irradiation, jet and pan-milling on structure and changes in properties of polymers were studied. Imposition of critical stress on polymer chain can cause the scission of bonds to form macroradicals. The macroradicals formed in this way may recombine or react with monomer or other radicals to form linear, branched or cross-linked polymers or copolymers. About 20 kinds of block/graft copolymers have been synthesized from polymer-polymer or polymer-monomer through ultrasonic irradiation.Through jet-milling, the molecular weight of PVC is decreased somewhat, the intensity of its crystalline absorption bonds becomes indistinct. The processability, the yield strength, strength at break and elongation at break of PVC get increased quite a lot after

  7. Modes of transference and rupture of the nucleus with neutron halos {sup 6} He on {sup 209} Bi near of the Coulomb barrier; Modos de transferencia y rompimiento del nucleo con halo neutronico {sup 6} He sobre {sup 209} Bi cerca de la barrera de Coulomb

    Energy Technology Data Exchange (ETDEWEB)

    Lizcano C, D

    2003-07-01

    In recent experiments, the fusion of the exotic radioactive nucleus {sup 6} He with {sup 209} Bi has been studied for the first time at energies above and below the Coulomb barrier. A considerable enhancement in the fusion was observed, which implies a reduction of about 25% in the nominal fusion barrier. Some previous theoretical works suggest that this striking effect may be caused by the coupling to neutron transfer channels with a positive Q-value which would lead to a neutron flow and the consequent formation of a neck between the projectile and the target. Later, in the current work, we ran two new experiments on the same reaction using the FN Tandem Van de Graaff (10 MV) accelerator and the dual superconducting TwinSol system, both of them belonging to the University of Notre Dame, USA. This time, the purpose was to study one- and two-neutron transfer and the {sup 6} He projectile breakup at laboratory energies of 14.7, 16.2, 17.9, 19.0 and 22.5 MeV. A strong group of {sup 4} He was observed (with an effective Q-value about .5 MeV) whose integrated cross section results exceptionally high, exceeding the fusion cross section both above and below the barrier. The simultaneously measured elastic scattering angular distribution required high total cross sections so that this yield is confirmed. Preliminary coupled channels calculations sing the computer program called Fresco developed at the University of Surrey (England) suggested that the reaction mechanisms may be better described as a direct nuclear breakup and two-neutron transfer to unbound states in {sup 211} Bi. These calculations predicted also an enhancement in the fusion cross section below the barrier due to the transfer and breakup channel coupling, which strongly suggests that this channel is the 'doorway state' that explains the fusion barrier reduction observed in previous experiments. It was found that the {sup 4} He group fully dominates the total reaction cross section at the

  8. Resource use and costs of exenatide bid or insulin in clinical practice: the European CHOICE study

    Directory of Open Access Journals (Sweden)

    Kiiskinen U

    2013-07-01

    Full Text Available Urpo Kiiskinen,1 Stephan Matthaei,2 Matthew Reaney,3 Chantal Mathieu,4 Claes-Göran Östenson,5 Thure Krarup,6 Michael Theodorakis,7,* Jacek Kiljanski,8 Carole Salaun-Martin,9 Hélène Sapin,9 Bruno Guerci10 1Eli Lilly, Helsinki, Finland; 2Quakenbrück Diabetes Center, Quakenbrück, Germany; 3Eli Lilly, Windlesham, Surrey, UK; 4Department of Endocrinology, UZ Gasthuisberg, Leuven, Belgium; 5Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; 6Department of Endocrinology, Bispebjerg Hospital, Copenhagen, Denmark; 7Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece; 8Eli Lilly, Warsaw, Poland; 9Eli Lilly, Neuilly Cedex, France; 10Department of Diabetes, Metabolic Diseases, and Nutrition, Hôpital Brabois, Vandoeuvre-Lès-Nancy, France *Michael Theodorakis was affiliated with the institution shown above at the time of the study, but has since left this institution Purpose: CHOICE (CHanges to treatment and Outcomes in patients with type 2 diabetes initiating InjeCtablE therapy assessed patterns of exenatide bid and initial insulin therapy usage in clinical practice in six European countries and evaluated outcomes during the study. Methods: CHOICE was a 24-month, prospective, noninterventional observational study. Clinical and resource use data were collected at initiation of first injectable therapy (exenatide bid or insulin and at regular intervals for 24 months. Costs were evaluated from the national health care system perspective at 2009 prices. Results: A total of 2515 patients were recruited. At the 24-month analysis, significant treatment change had occurred during the study in 42.2% of 1114 eligible patients in the exenatide bid cohort and 36.0% of 1274 eligible patients in the insulin cohort. Improvements in glycemic control were observed over the course of the study in both cohorts (P < 0.001 for both, but mean weight was reduced in the exenatide bid cohort (P < 0

  9. Treatment outcomes after initiation of exenatide twice daily or insulin in clinical practice: 12-month results from CHOICE in six European countries

    Directory of Open Access Journals (Sweden)

    Ostenson CG

    2013-04-01

    Full Text Available Claes-Göran Östenson,1 Stephan Matthaei,2 Matthew Reaney,3 Thure Krarup,4 Bruno Guerci,5 Jacek Kiljanski,6 Carole Salaun-Martin,7 Hélène Sapin,7 David Bruhn,8 Chantal Mathieu,9 Michael Theodorakis10 1Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden; 2Diabetes-Center Quakenbrück, Quakenbrück, Germany; 3Eli Lilly, Windlesham, Surrey, UK; 4Department of Endocrinology I, Bispebjerg Hospital, Copenhagen, Denmark; 5Diabetology, Metabolic Diseases and Nutrition, Brabois Hospital, CHU Nancy, and INSERM CIC, ILCV, Vandoeuvre Lès Nancy, France; 6Eli Lilly, Warsaw, Poland; 7Eli Lilly, Neuilly Cedex, France; 8Eli Lilly, San Diego, California, USA; 9Department of Endocrinology, UZ Gasthuisberg, Leuven, Belgium; 10Department of Clinical Therapeutics, University of Athens School of Medicine, Athens, Greece* *Michael Theodorakis was affiliated with the institution shown at the time of the study, but has since left this institution Objective: The CHanges to treatment and Outcomes in patients with type 2 diabetes initiating InjeCtablE therapy (CHOICE study assessed time to, and reasons for, significant treatment change after patients with type 2 diabetes (T2DM initiated their first injectable glucose-lowering therapy (exenatide twice daily [BID] or insulin in routine clinical practice, and these patients’ clinical outcomes, in six European countries. This paper reports interim data from the first 12 months of the study. Research design and methods: CHOICE (NCT00635492 is a prospective, noninterventional, observational study. Clinical data were collected at initiation of first injectable therapy and after approximately 3, 6, and 12 months. Results: Of 2497 patients enrolled in CHOICE, 1096 in the exenatide BID and 1239 in the insulin cohorts had ≥1 post-baseline assessment and were included in this analysis. Overall, 32.2% of the exenatide BID cohort and 29.1% of the insulin cohort (Kaplan–Meier estimates had

  10. Challenges and prospects for the control of foot-and-mouth disease: an African perspective

    Directory of Open Access Journals (Sweden)

    Maree FF

    2014-10-01

    Full Text Available Francois F Maree,1,2 Christopher J Kasanga,3, Katherine A Scott,1 Pamela A Opperman,1,2 Melanie Chitray,1,2, Abraham K Sangula,4 Raphael Sallu,3 Yona Sinkala,5 Philemon N Wambura,3 Donald P King,6 David J Paton,6 Mark M Rweyemamu,3 1Transboundary Animal Diseases Programme, Onderstepoort Veterinary Institute, Agricultural Research Council, Onderstepoort, Pretoria, South Africa; 2Department of Microbiology and Plant Pathology, Faculty of Agricultural and Natural Sciences, University of Pretoria, Pretoria, South Africa; 3Southern African Centre for Infectious Diseases Surveillance, Sokoine University of Agriculture, Morogoro, Tanzania; 4Foot-and-Mouth Disease Laboratory, Embakasi, Nairobi, Kenya; 5Department of Disease Control, School of Veterinary Medicine, University of Zambia, Lusaka, Zambia; 6The Pirbright Institute, Pirbright, Surrey, UK Abstract: The epidemiology of foot-and-mouth disease (FMD in Africa is unique in the sense that six of the seven serotypes of FMD viruses (Southern African Territories [SAT] 1, SAT2, SAT3, A, O, and C, with the exception of Asia-1, have occurred in the last decade. Due to underreporting of FMD, the current strains circulating throughout sub-Saharan Africa are in many cases unknown. For SAT1, SAT2, and serotype A viruses, the genetic diversity is reflected in antigenic variation, and indications are that vaccine strains may be needed for each topotype. This has serious implications for control using vaccines and for choice of strains to include in regional antigen banks. The epidemiology is further complicated by the fact that SAT1, SAT2, and SAT3 viruses are maintained and spread by wildlife, persistently infecting African buffalo in particular. Although the precise mechanism of transmission of FMD from buffalo to cattle is not well understood, it is facilitated by direct contact between these two species. Once cattle are infected they may maintain SAT infections without the further involvement of buffalo. No

  11. PIXE and cSAXS studies at the bone-cartilage interface

    International Nuclear Information System (INIS)

    Kaabar, W.; Gundogdu, O.; Bradley, D.A.; Bunk, O.; Pfeiffer, F.; Farquharson, M.J.; Webb, M.; Jeynes, C.

    2008-01-01

    Full text: Divalent cations such as Zn and Ca play a central role both in the normal processes of growth and remodelling as well as in the degenerative and inflammatory processes of articular cartilage during arthritis. These cations act as co-factors of a class of enzymes known as metalloproteinases, believed to be active during the initiation, progress and remodelling processes associated with osteoarthritis. Other important enzymes such as alkaline phosphatase, involved in cartilage mineralization, are also associated with the presence of these metallic co-factors. A number of authors have used X-ray fluorescence, employing synchrotron radiation sources to map metal ion distributions in bone and cartilage. In the present work, investigations were carried out on the distribution of metallic ions (Zn, Ca, P and S) in articular cartilage samples at the University of Surrey hosted EPSRC national ion beam facility based on a 2 MV Tandetron accelerator. An in-air beam line was used, with proton energy of 2.5 MeV. Micro Proton-Induced X-ray Emission (μ-PIXE) analysis has been made of the bone-cartilage interface for samples taken from the human femoral head. The bone-cartilage interface region between uncalcified and mineralized cartilage regions has attracted particular interest, being identified to be an active site of remodelling. Here coherent small angle X-ray scattering (cSAXS) has also been employed to investigate the structure and organization of the collagen network in decalcified diseased human femoral heads and the equine metacarpus joint, study being carried out at the Paul Scherrer Institute (PSI) synchrotron beamline cSAXS. (Fig. 1: cSAXS over a 1 mm x 1.5 mm area of a cartilage/bone sample; the left- and right hand panels corresponds to the length scales 658-568 A and 962-833 A respectively. The bar scale indicates relative orientation, from 0 deg (blue) to 90 deg (red)). The results of Fig. 1 are plotted in terms of orientation of cartilage and bone

  12. Using Spacecraft in Climate and Natural Disasters Registration

    Science.gov (United States)

    Sokol, Galyna; Kotlov, Vladyslav; Khorischenko, Oleksandr; Davydova, Angelica; Heti, Kristina

    2017-04-01

    Since the beginning of the space age it become possible the global monitoring of the planet Earth's state. Since the second half of the 20th century there are observations of the atmosphere's state and the Earth's climate have been held by a spacecraft. Also become possible large-scale monitoring of climate change. An attempt was made to define the role of infrasound in the interaction between a space weather, climate and biosphere of the Earth using spacecraft sensors recording. Many countries are involving in the detection of earthquakes, predicting volcanic eruptions and floods and also the monitoring of irregular solar activity. Understanding this leads to the conclusion that international cooperation for the protection of humanity is not only a political priority in the international arena, but also a question of the quality of living standards of any state. Commonly known following monitoring systems: Disaster Monitoring Constellation (DMC), FUEGO program (Spain), Sentinel-Asia program (Japan) and International aerospace system for monitoring of global phenomena (MAKCM, Russia). The Disaster Monitoring Constellation for International Imaging (DMCii) consists of a number of remote sensing satellites constructed by Surrey Satellite Technology Ltd (SSTL) and operated for the Algerian, Nigerian, Turkish, British and Chinese governments by DMC International Imaging. The DMC has monitored the effects and aftermath of the Indian Ocean Tsunami (December 2004), Hurricane Katrina (August 2005), and many other floods, fires and disasters. The individual DMC satellites are: 1. First generation satellites (AlSAT-1 - Algeria, BilSAT - Turkey, NigeriaSAT-1 - Nigeria, UK-DMC - United Kingdom); 2. Second generation satellites (Beijing - China, UK-DMC 2 - United Kingdom, Deimos-1 - Spanish commercial, NigeriaSAT-2 and NigeriaSAT-X). The sun-synchronous orbits of these satellites are coordinated so that the satellites follow each other around an orbital plane, ascending north

  13. Modes of transference and rupture of the nucleus with neutron halos 6 He on 209 Bi near of the Coulomb barrier

    International Nuclear Information System (INIS)

    Lizcano C, D.

    2003-01-01

    In recent experiments, the fusion of the exotic radioactive nucleus 6 He with 209 Bi has been studied for the first time at energies above and below the Coulomb barrier. A considerable enhancement in the fusion was observed, which implies a reduction of about 25% in the nominal fusion barrier. Some previous theoretical works suggest that this striking effect may be caused by the coupling to neutron transfer channels with a positive Q-value which would lead to a neutron flow and the consequent formation of a neck between the projectile and the target. Later, in the current work, we ran two new experiments on the same reaction using the FN Tandem Van de Graaff (10 MV) accelerator and the dual superconducting TwinSol system, both of them belonging to the University of Notre Dame, USA. This time, the purpose was to study one- and two-neutron transfer and the 6 He projectile breakup at laboratory energies of 14.7, 16.2, 17.9, 19.0 and 22.5 MeV. A strong group of 4 He was observed (with an effective Q-value about .5 MeV) whose integrated cross section results exceptionally high, exceeding the fusion cross section both above and below the barrier. The simultaneously measured elastic scattering angular distribution required high total cross sections so that this yield is confirmed. Preliminary coupled channels calculations sing the computer program called Fresco developed at the University of Surrey (England) suggested that the reaction mechanisms may be better described as a direct nuclear breakup and two-neutron transfer to unbound states in 211 Bi. These calculations predicted also an enhancement in the fusion cross section below the barrier due to the transfer and breakup channel coupling, which strongly suggests that this channel is the 'doorway state' that explains the fusion barrier reduction observed in previous experiments. It was found that the 4 He group fully dominates the total reaction cross section at the measured energies and we show evidence that a new

  14. Book Reviews

    Directory of Open Access Journals (Sweden)

    Raymond L. Bryant

    1999-04-01

    Full Text Available - R.H. Barnes, Janet Hoskins, Biographical objects; How things tell the stories of people’s lives. London: Routledge, 1998, x + 213 pp. - Peter Boomgaard, Ann Kumar, Java and modern Europe; Ambiguous encounters. Richmond, Surrey: Curzon, 1997, vii + 472 pp. - Peter Boomgaard, Lenore Manderson, Sickness and the state; Health and illness in colonial Malaya, 1870-1940. Cambridge: Cambridge University Press, 1996, xix + 315 pp. - Matthew Isaac Cohen, Bambang Widoyo, Gapit; 4 naskah drama berbahasa Jawa: Rol, Leng, Tuk dan Dom. Yogyakarta: Yayasan Benteng Budaya, 1998, xiv + 302 pp. - James T. Collins, Bernd Nothofer, Reconstruction, classification, description; Festschrift in honor of Isidore Dyen. Hamburg: Abera, 1996, xiv + 259 pp. - J.R. Flenley, Kristina R.M. Beuning, Modern pollen rain, vegetation and climate in lowland East Java, Indonesia. Rotterdam: Balkema, 1996, 51 pp. + 49 plates. [Modern Quaternary Research in Southeast Asia 14.] - Gregory Forth, Karl-Heinze Kohl, Der Tod der Riesjungfrau; Mythen, Kulte und Allianzen in einer ostindonesischen Lokalkultur. Stuttgart: Kohlhammer, 1998, 304 pp. [Religionsethnologische Studien des Frobenius-Instituts Frankfurt am Main, Band I.] - J. van Goor, Brook Barrington, Empires, imperialism and Southeast Asia; Essays in honour of Nicholas Tarling. Clayton, Victoria: Monash Asia Institute, 1997, v + 250 pp. [Monash Papers on Southeast Asia 43.] - Mies Grijns, Penny van Esterik, Women of Southeast Asia. DeKalb: Center for Southeast Asian Studies, Northern Illinois University, 1996, xiv + 229 pp. ‘Monographs on Southeast Asia, Occasional Paper 17; Second, revised edition.] - Hans Hagerdal, Alfons van der Kraan, Bali at war; A history of the Dutch-Balinese conflict of 1846-49. Clayton, Victoria: Centre of Southeast Asian Studies, Monash University, 1995, x + 240 pp. [Monash Papers on Southeast Asia 34]. - Volker Heeschen, Jurg Wassmann, Das Ideal des leicht gebeugten Menschen; Eine ethnokognitive

  15. Daily supplementation with 15 μg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial.

    Science.gov (United States)

    Tripkovic, Laura; Wilson, Louise R; Hart, Kathryn; Johnsen, Sig; de Lusignan, Simon; Smith, Colin P; Bucca, Giselda; Penson, Simon; Chope, Gemma; Elliott, Ruan; Hyppönen, Elina; Berry, Jacqueline L; Lanham-New, Susan A

    2017-08-01

    Background: There are conflicting views in the literature as to whether vitamin D 2 and vitamin D 3 are equally effective in increasing and maintaining serum concentrations of 25-hydroxyvitamin D [25(OH)D], particularly at lower doses of vitamin D. Objective: We aimed to investigate whether vitamin D 2 or vitamin D 3 fortified in juice or food, at a relatively low dose of 15 μg/d, was effective in increasing serum total 25(OH)D and to compare their respective efficacy in South Asian and white European women over the winter months within the setting of a large randomized controlled trial. Design: A randomized, double-blind, placebo-controlled food-fortification trial was conducted in healthy South Asian and white European women aged 20-64 y ( n = 335; Surrey, United Kingdom) who consumed placebo, juice supplemented with 15 μg vitamin D 2 , biscuit supplemented with 15 μg vitamin D 2 , juice supplemented with 15 μg vitamin D 3 , or biscuit supplemented with 15 μg vitamin D 3 daily for 12 wk. Serum 25(OH)D was measured by liquid chromatography-tandem mass spectrometry at baseline and at weeks 6 and 12 of the study. Results: Postintervention in the 2 ethnic groups combined, both the vitamin D 3 biscuit and the vitamin D 3 juice groups showed a significantly greater absolute incremental change (Δ) in total 25(OH)D when compared with the vitamin D 2 biscuit group [Δ (95% CI): 15.3 nmol/L (7.4, 23.3 nmol/L) ( P < 0.0003) and 16.0 nmol/L (8.0, 23.9 nmol/L) ( P < 0.0001)], the vitamin D 2 juice group [Δ (95% CI): 16.3 nmol/L (8.4, 24.2 nmol/L) ( P < 0.0001) and 16.9 nmol/L (9.0, 24.8 nmol/L) ( P < 0.0001)], and the placebo group [Δ (95% CI): 42.3 nmol/L (34.4, 50.2 nmol/L) ( P < 0.0001) and 42.9 nmol/L (35.0, 50.8 nmol/L) ( P < 0.0002)]. Conclusions: With the use of a daily dose of vitamin D relevant to public health recommendations (15 μg) and in vehicles relevant to food-fortification strategies, vitamin D 3 was more effective than vitamin D 2 in increasing

  16. Functioning in patients with major depression treated with duloxetine or a selective serotonin reuptake inhibitor in East Asia

    Directory of Open Access Journals (Sweden)

    Novick D

    2016-02-01

    Full Text Available Diego Novick,1 William Montgomery,2 Josep Maria Haro,3 Maria Victoria Moneta,3 Gang Zhu,4 Li Yue,5 Jihyung Hong,6 Héctor Dueñas,7 Roberto Brugnoli8 1Eli Lilly and Company, Windlesham, Surrey, UK; 2Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 3Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain; 4Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, 5Lilly Suzhou Pharmaceutical Company, Ltd, Shanghai, People’s Republic of China; 6Department of Healthcare Management, Gachon University, Seongnam, South Korea; 7Eli Lilly de Mexico, Mexico City, Mexico; 8School of Medicine, Sapienza University of Rome, Rome, ItalyPurpose: To assess and compare the levels of functioning in patients with major depressive disorder treated with either duloxetine with a daily dose of ≤60 mg or a selective serotonin reuptake inhibitor (SSRI as monotherapy for up to 6 months in a naturalistic setting in East Asia. In addition, this study examined the impact of painful physical symptoms (PPS on the effects of these treatments.Patients and methods: Data for this post hoc analysis were taken from a 6-month prospective observational study involving 1,549 patients with major depressive disorder without sexual dysfunction. The present analysis focused on a subgroup of patients from East Asia (n=587. Functioning was measured using the Sheehan Disability Scale (SDS. Depression severity was assessed using the 16-item Quick Inventory of Depressive Symptomatology-Self Report. PPS were rated using the modified Somatic Symptom Inventory. A mixed model with repeated measures was fitted to compare the levels of functioning between duloxetine-treated (n=227 and SSRI-treated (n=225 patients, adjusting for baseline patient characteristics.Results: The mean SDS total score was similar between the two treatment cohorts (15.46 [standard deviation =6.11] in the duloxetine

  17. Nigeria's Satellite Programme Development: Prospects and Challenges

    Science.gov (United States)

    Akinyede, Joseph

    Nigeria's desire to maximize the benefits of space technology for its sustainable development, has become a reality with the establishment of the National Space Research and Development Agency (NASRDA) in May 1999 and the approval of the national Space Policy and Programmes in July 2001. In November, 2000, the Federal Government took a bold step with the signing of an agreement with the Surrey Satellite Technology Limited (SSTL) of United Kingdom (UK) for the design, construction and launch of a medium resolution micro-satellite - NigeriaSat-1 with a Ground Sampling Distance of thirty-two (32) meters. The agreement also covers the Know-How-Technology-Training (KHTT) to Nigerian Engineers and Scientists for a period of 18th months at SSTL‘s facility in the U.K.. NigeriaSat-1 was successfully launched into Leo Earth Orbit on 27th September, 2003. NigeriaSat- 1 is one of the five (5) satellites belonging to Nigeria, Algeria, Turkey, United Kingdom and China being operated in a Disaster Monitoring Constellation (DMC). The launch of NigeriaSat-1 has promoted access to information which has become a strategy for mass socio-economic development, as information underscores all developmental effort be it in education, provision of health services, marketing, construction industry, tourism, defense, etc. As a follow-up to the successful launch of NigeriaSat-1, the government of Nigeria started the implementation of a Nigerian communication satellite (NigcomSat-1) to address the problem of communication which is the greatest drawbacks to the socio-economic development of the country, particularly in the areas of rural telephone, tele-education, tele-medicine, egovernment, e-commerce and real-time monitoring services. NigcomSat-1, which carries 40- hybrid transponders in the C, KU, KA and L bands, has a 15 years life span and coverage of the African continent, Middle East and part of Europe was launched in May 2007. To satisfy geospatial data needs in sectors such as survey

  18. Solar and Drag Sail Propulsion: From Theory to Mission Implementation

    Science.gov (United States)

    Johnson, Les; Alhorn, Dean; Boudreaux, Mark; Casas, Joe; Stetson, Doug; Young, Roy

    2014-01-01

    , and began its mission after it was ejected from the FASTSAT into Earth orbit, where it remained for several weeks before deorbiting as planned. NASA recently selected two small satellite missions for study as part of the Advanced Exploration Systems (AES) Program, both of which will use solar sails to enable their scientific objectives. Lunar Flashlight, managed by JPL, will search for and map volatiles in permanently shadowed Lunar craters using a solar sail as a gigantic mirror to steer sunlight into the shaded craters. The Near Earth Asteroid (NEA) Scout mission will use the sail as primary propulsion allowing it to survey and image one or more NEA's of interests for possible future human exploration. Both are being studied for possible launch in 2017. The Planetary Society's privately funded LightSail-A and -B cubesat-class spacecraft are nearly complete and scheduled for launch in 2015 and 2016, respectively. MMA Design launched their DragNet deorbit system in November 2013, which will deploy from the STPSat-3 spacecraft as an end of life deorbit system. The University of Surrey is building a suite of cubesat class drag and solar sail systems that will be launched beginning in 2015. As the technology matures, solar sails will increasingly be used to enable science and exploration missions that are currently impossible or prohibitively expensive using traditional chemical and electric rockets. For example, the NASA Heliophysics Decadal Survey identifies no less than three such missions for possible flight before the mid-2020's. Solar and drag sail propulsion technology is no longer merely an interesting theoretical possibility; it has been demonstrated in space and is now a critical technology for science and solar system exploration.

  19. Switching to olanzapine long-acting injection from either oral olanzapine or any other antipsychotic: comparative post hoc analyses

    Directory of Open Access Journals (Sweden)

    Ciudad A

    2013-11-01

    Full Text Available Antonio Ciudad,1 Ernie Anand,2 Lovisa Berggren,3 Marta Casillas,4 Alexander Schacht,3 Elena Perrin5 1Department of Clinical Research and Development, Eli Lilly & Co, Madrid, Spain; 2Neuroscience Medical Affairs – EU, Lilly Research Centre, Windlesham, Surrey, UK; 3Global Statistical Sciences, Eli Lilly & Co, Bad Homburg, Germany; 4European Scientific Communications, Eli Lilly & Co, Madrid, Spain; 5Medical Department, Eli Lilly & Co, Suresnes, Paris, France Background: A considerable proportion of patients suffering from schizophrenia show suboptimal responses to oral antipsychotics due to inadequate adherence. Hence, they are likely to benefit from switching to a long-acting injectable formulation. These post hoc analyses assessed the clinical effects of switching to olanzapine long-acting injection (OLAI from either oral olanzapine (OLZ or other antipsychotics (non-OLZ. Methods: Post hoc analyses were done based on two randomized studies (one short-term, one long-term conducted in patients suffering from schizophrenia and treated with OLAI. The short-term study was an 8-week placebo-controlled, double-blind trial in acute patients, and the long-term study was a 2-year, oral olanzapine-controlled, open-label, follow-up of stabilized outpatients. Results: These analyses used data from 62 OLAI-treated patients (12 switched from OLZ, 50 from non-OLZ from the short-term study and 190 OLAI-treated patients (56 switched from OLZ, 134 from non-OLZ from the long-term study. Kaplan–Meier survival analyses of time to all-cause discontinuation of OLAI treatment did not differ significantly between OLZ and non-OLZ patients in the short-term study (P=0.209 or long-term study (P=0.448. Similarly, the proportions of OLZ and non-OLZ patients that discontinued OLAI were not statistically different in the short-term (16.7% versus 36.0%, respectively; P=0.198 or long-term (57.1% versus 47.8% respectively; P=0.238 studies. In the short-term study, no

  20. Radon, radionuclides and the Cretaceous Folkestone Sands - gamma spectroscopy and geochemical analysis of silver sands and associated deposits in the SE of England.

    Science.gov (United States)

    Gillmore, Gavin; Al-Rafai, Yousef; Flowers, Alan

    2017-04-01

    Radon concentrations in a historic sand mine in Surrey, UK (Reigate Caves), have been measured by both real-time and time-averaged methods over a number of years. These mines are not identified as being in a 'Radon Affected Area' as defined by Public Health England, although concentrations show a summer level of 640 Bqm3 +-44 Bqm3. Average radon concentrations (September 2013 to January 2014) in Reigate caves were above the UK 200 Bqm3 domestic Action Level, above the UK domestic Target Level (of 100 Bqm3) but below the current workplace Action Level of 400 Bqm3. By way of a comparison radon has also been measured in nearby Dorking (South Street Caves). These enigmatic caves were not mined for sand for glass manufacture as Reigate Caves were and there is speculation on why the caves were created. Both are visited by tourists on a semi-regular basis. Dorking caves have a different morphology with radon concentrations in Autumn 2016 of up to 1940 +/- 230 Bqm3. The caves in Reigate are situated along Tunnel Road. These mines were also used as air raid shelters and wine stores. They consist of an East and West system and an older cave (Barons cave) which may have a medieval origin. As the Western Caves are now a shooting range our work has been carried out in the Eastern section at Reigate. Where Dorking is concerned the shops and houses in the town have extensive interconnected cellars and galleries cut into these sands. The caves probably date from the 17th century but were used quite extensively for wine storage in the 19th century due to their constant 140C air temperatures. Real-time measurements were taken with a Durridge Rad7 with time-averaged CR39 SSNTDs being placed throughout the cave systems to assess radon distribution and compare results with the real-time detector. Both caves contain marine shallow-water deposited locking (having tensile and compressive strength) silica sands of the Cretaceous Lower Greensand Group, Folkestone Formation, with little

  1. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2001-10-01

    Full Text Available -Doris Jedamski, René Witte, De Indische radio-omroep; Overheidsbeleid en ontwikkeling, 1923-1942. Hilversum: Verloren, 1998, 202 pp. -Edwin Jurriëns, Philip Kitley, Television, nation, and culture in Indonesia. Athens, Ohio: Ohio University Center for International Studies, 2000, xviii + 411 pp. [Research in International Studies, Southeast Asia Series 104.] -Gerrit Knaap, Scott Merrillees, Batavia in nineteenth century photographs. Richmond, Surrey: Curzon, 2000, 282 pp. -C.C. MacKnight, David Bulbeck ,Land of iron; The historical archaelogy of Luwu and the Cenrana valley; Results of the Origin of Complex Society in South Sulawesi Project (OXIS. Hull and Canberra: Centre for South-East Asian Studies, University of Hull / School of Archaeology and Anthropology, Australian National University, 2000, vi + 141 pp., Ian Caldwell (eds -Niels Mulder, Toh Goda, Political culture and ethnicity; An anthropological study in Southeast Asia. Quezon City: New Day, 1999, xviii + 182 pp. -Niels Mulder, Norman G. Owen, The Bikol blend; Bikolanos and their history. Quezon City: New Day, 1999, x + 291 pp. -Anton Ploeg, Donald Tuzin, Social complexity in the making; A case study among the Arapesh of New Guinea. London: Routledge, 2001, xii + 159 pp. -Henk Schulte-Nordholt, Maarten Kuitenbrouwer, Tussen oriëntalisme en wetenschap; Het Koninklijk Instituut voor Taal-, Land- en Volkenkunde in historisch verband 1851-2001. Leiden: KITLV Uitgeverij, 2001, ix + 362 pp. -Sri Margana, Peter Carey ,The archive of Yogyakarta, Volume II, Documents relating to economic and agrarian affairs. New York: Oxford University Press, 2000, 566 pp., Mason C. Hoadley (eds -Eric Venbrux, Wilfried van Damme, Bijdragen over kunst en cultuur in Oceanië/Studies in Oceanic Art and Culture. Gent: Academia Press, 2000, 122 pp. -Edwin Wieringa, Raharjo Suwandi, A quest for justice; The millenary aspirations of a contemporary Javanese wali. Leiden: KITLV Press, 2000, x + 229 pp

  2. Khat use as risk factor for psychotic disorders: A cross-sectional and case-control study in Somalia

    Directory of Open Access Journals (Sweden)

    Elbert Thomas

    2005-02-01

    Full Text Available Abstract Background Little is known about the prevalence of khat-induced psychotic disorders in East African countries, where the chewing of khat leaves is common. Its main psycho-active component cathinone produces effects similar to those of amphetamine. We aimed to explore the prevalence of psychotic disorders among the general population and the association between khat use and psychotic symptoms. Methods In an epidemiological household assessment in the city of Hargeisa, North-West Somalia, trained local interviewers screened 4,854 randomly selected persons from among the general population for disability due to severe mental problems. The identified cases were interviewed based on a structured interview and compared to healthy matched controls. Psychotic symptoms were assessed using the items of the WHO Composite International Diagnostic Interview and quantified with the Positive and Negative Symptoms Scale. Statistical testing included Student's t-test and ANOVA. Results Local interviewers found that rates of severe disability due to mental disorders were 8.4% among males (above the age of 12 and differed according to war experiences (no war experience: 3.2%; civilian war survivors: 8.0%; ex-combatants: 15.9%. The clinical interview verified that in 83% of positive screening cases psychotic symptoms were the most prominent manifestations of psychiatric illness. On average, cases with psychotic symptoms had started to use khat earlier in life than matched controls and had been using khat 8.6 years before positive symptoms emerged. In most cases with psychotic symptoms, a pattern of binge use (> two 'bundles' per day preceded the onset of psychotic symptoms, in contrast to controls of the same age. We found significant correlations between variables of khat consumption and clinical scales (0.35 to 0.50; p Conclusion Evidence indicates a relationship between the consumption of khat and the onset of psychotic symptoms among the male

  3. Quality in university physics teaching: is it being achieved?

    Science.gov (United States)

    1998-11-01

    ) satisfied the doubters with a tantalisingly brief description of how the new IoP-sponsored post-16 course intends to tackle this perennial problem. Perhaps mathematics worriers could learn from the efforts being made by several universities to tackle the problem of illiterate physics students. Chris Hall from Warwick described how the Physics Department shared in, developed and adapted a whole-university project - the Warwick Writing Programme - with clear instructions, models and assessment tasks which targeted clearly defined skills in context. And it worked. It sounded a lot like Nuffield A-Level's Research and Analysis to me, but we all know that the school-university interface is semi-permeable at best. This account of a fascinating two days could go on and on. So briefly: James Miller, as Head of Newcastle Royal Grammar School, an ancestral voice prophesying doom, foresaw the demise of university physics mainly because state schools didn't have good labs, enough physics teachers or good discipline, and even when they did they probably taught some kind of general science so that their pupils never even heard of physics. How things must have changed since I stopped teaching. David Baume (FDTL (don't ask)) of the Open University made us do some work in groups and think up what qualities a good physics teacher needs. There were few surprises here, but as a physics `drop-out' Dr Baume was keen on the idea that courses should be more openly structured so that students knew where they were and indeed where they were going. Dave Wonnacott (CTI, Surrey University) showed us some up-to-date teaching software, emphasizing that the current problem was not in finding good stuff but in integrating it into courses. Finally (more or less) we were shown how all these things should be done by Dr Dick Moyes of the chemists' Project Improve. This has been up and running for several years and has organized workshops, training sessions, secondments for producing `transportable ideas' for

  4. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2002-07-01

    , Maine: Borneo Research Council, 2001, xiv + 279 pp. [BRC Monograph Series 5.] -Nicholas J. White, Francis Loh Kok Wah ,Democracy in Malaysia; Discourses and practices. Richmond, Surrey: Curzon Press, 2002, xiii + 274 pp. [Nordic Institute of Asian Studies Democracy in Asia Series 5.], Khoo Boo Teik (eds

  5. EDITORIAL: Physical behaviour at the nanoscale: a model for fertile research Physical behaviour at the nanoscale: a model for fertile research

    Science.gov (United States)

    Demming, Anna

    2013-06-01

    increasing availability of nanomaterials provided a number of advantages for research in field emission for displays, microwave and x-ray generation, electron-beam lithography and photonic devices [5, 6]. However the results reported in these studies have often misapplied the Fowler-Nordheim theory for describing field-emission behaviour, as changes in scale alter the validity of the widely cited simplified equation. As Forbes at the University of Surrey points out, this equation over-predicts the large-area field-emission average current density by a large highly variable factor thought to usually lie between 103 and 109. In his paper he explains how to modify the Fowler-Nordheim type equations so that they can be applied to large-area field emitters with recommendations for improved practice in this area of research [7]. The unusual nuances of behaviour in electronic circuits at the nanoscale has piqued avid interest in 'the memristor', the fourth circuit element reported 'missing' by Leon Chua in 1971 [8] and 'found' by researchers at HP Labs in 2008 [9]. The past five years have seen intense research into the mechanisms governing memristor behaviour [10], as well as the potential to apply this behaviour in novel electronic devices capable of mimicking the biological synapses that implement human learning [11]. (Keep an eye out for Nanotechnology's special issue on synaptic electronics later this year.) However, as Di Ventra and Pershin point out, 'Although this whole field of research has been growing at a fast pace, there is still much confusion about the fundamental physical properties that realistic systems with memory (as opposed to ideal ones) satisfy'. In this issue they derive expressions for memristances, memcapacitances and meminductances from the Kubo response and microscopic theories and show that they are indeed simply response functions that satisfy well defined physical properties. In the midst of concrete facts, cutting edge research often exploits cracks

  6. Obituary: Thomas Gold, 1920-2004

    Science.gov (United States)

    Dermott, Stanley F.

    2004-12-01

    Thomas "Tommy" Gold died of heart disease at Cayuga Medical Center, Ithaca NY on 22 June 2004 at the age of 84. He will be remembered as one of the most interesting, dynamic and influential scientists of his generation. Tommy's paradigm-changing ideas in astronomy and planetary science, while original and bold, were also highly controversial. With his radical work on the origin of natural gas and petroleum, the controversy is likely to continue. Tommy was born in Vienna, Austria on 22 May 1920, moving with his family to Berlin at age 10 and then, after the rise of Hitler in 1933, to England. His parents were Josephine (nee Martin) and Maximillian Gold, a successful steel magnate. Tommy was educated at Zuoz College in Switzerland where he became an expert skier and developed an athletic prowess that he maintained throughout his life, winning a NASTAR gold medal for skiing at the age of 65. He studied Mechanical Sciences at Trinity College, Cambridge, but much to his disgust his education was interrupted because of internment by the British as a suspected enemy alien. That unfortunate period (I remember him saying to me "Can you believe the stupidity, interring people like me who had fled from Nazi Germany?") had one good outcome: on his first night in camp he met Hermann Bondi who had an important influence on his early development as a scientist. They were both born in Vienna, their parents knew each other, and they were fellow students at Trinity, but this was their first meeting. On release, he went immediately into top-secret radar research for the British Admiralty, working as a team with Bondi and Fred Hoyle in a farm cottage in Dunsfold, Surrey. Tommy's first published research, which was a Nature paper with R.J. Pumphrey in 1947, was not in astronomy but physiology. He applied his engineer's understanding of positive feedback to develop and test a resonance model for how the human ear determines pitch. His conclusion that pitch discrimination occurs

  7. PREFACE: Rutherford Centennial Conference on Nuclear Physics

    Science.gov (United States)

    Freeman, Sean

    2012-09-01

    , giving a really excellent set of presentations. Finally we are also pleased to express our thanks to the Conference Office of the Institute of Physics for their invaluable support in organising this event. We are especially grateful to Dawn Stewart for her responsive and efficient day-to-day handling of this event, as well as to Claire Garland for her planning and management of this event. This conference is the second in a series of conferences that began with the Rutherford Jubilee Conference held in Manchester in 1961, which is described in one of the contributions to these proceedings. I do hope that at least some of the delegates from the Centennial Conference will be able to attend the next one, fifty years hence in 2061, just as we were honoured to have some of the Jubilee delegates with us for the Centennial. If I am still around, I doubt that I will have the energy then to be conference chair. I would also not like to attempt to predict the plenary programme, but I hope that it will be as vibrant and exciting as the 2011 conference. Professor Sean J Freeman Conference Chair On behalf of the UK Organising Committee Ernest Rutherford Ernest Rutherford (Photograph courtesy of The University of Manchester) Edited by: Sean Freeman (The University of Manchester) Andrei Andreyev (University of the West of Scotland/The University of York) Alison Bruce (University of Brighton) Alick Deacon (The University of Manchester) Dave Jenkins (University of York) Dave Joss (University of Liverpool) Douglas MacGregor (University of Glasgow) Paddy Regan (University of Surrey) John Simpson (University of Daresbury) Garry Tungate (University of Birmingham) Bob Wadsworth (University of York) Dan Watts (University of Edinburgh) International Advisory Panel: A Aprahamian (Notre Dame, USA) J Äystö (Jyväskylä, Finland) F Aziaez (Orsay, France) J-P Blaizot (Saclay, France/ECT, Italy) A Bracco (Milan, Italy) H Caines (Yale, USA) C W de Jaeger (JLAB, USA) J Dilling (TRIUMF, Canada) J

  8. Bilimsel Toplantı Duyuruları

    Directory of Open Access Journals (Sweden)

    Adli Tıp Uzmanları Derneği ATUD

    2006-12-01

    : Cambridge Healthtech Institute 250 First Avenue, Suite 300 Needham, MA 02494 (781 972-5400 or (888 999-6288 - Fax: (781 972-5425 www.healthtech.com SCANNING 2007 “Scanning Microscopy In Forensics Science” 10-12 April 2007 CA,USA Further information S. Frank Platek, Forensic Chemistry Center, US Food and Drug Administration, 6751 Steger Drive, Cincinnati, OH Tel: 513-679-2700 x254 - Email: fplatek@ora.fda.gov Web: www.fams.org The 9th Annual Conference of BAHID 12-14 April 2007, United Kingdom University of Surrey, Guildford Further information: Web:www.bahid.org AFDIL’s International Training Course 16-20 April 2007, USA Extraction of DNA from Aged Skeletal Remains and Forensic Mitochondrial DNA Sequence Further information: The Armed Forces DNA Identification Laboratory, 1413 Research Blvd, Bldg, 101, Rockville, MD 20850 25th Annual CME Symposium in Forensic Psychiatry April 26-29, 2007 Santa Fe, New Mexico - Inn and Spa at Loretto Further information: American College of Forensic Psychiatry PO Box 5870, Balboa Island CA 92662 Tel: (949 673-7773 - www.forensicpsychonline.com Scanning Microscopy in Forensic Science - A 3-Day Symposium at SCANNING 2007 10-12 April To be held at the Portola Plaza Hotel at Monterey Bay in Monterey, CA. Mark K. Sullivan Program Planning Committee SCANNING 2007 PO Box 485 Mahwah, NJ 07430-0485 (201 818-1010 Fax: (201 818-0086 mks@fams.org - www.fams.org -www.scanning2007.org 7th Annual Proteomic and Genomic Sample Preparation Conference - Optimizing Samples for Diagnostics and Drug Discovery 11-13 April To be held at the World Trade Center in Boston, MA. Margit Eder, PhD Conference Director Cambridge Healthtech Institute (781 972-5478 - Fax: (781 972-5425 meder@healthtech.com - www.GOTSummit.com Forensic Medical Investigation Comprehensive Review Course 11-13 April To be held in Atlantic City, NJ. CONTACT: Michael Henderson or Mary Dudley, MD Forensic Medical Investigation Institute 6505 East Central; PMB#176 Wichita, KS 67206-1924 mike

  9. Letters

    Science.gov (United States)

    2001-03-01

    the bulk modulus and ρ is the density. Note that the speed is inversely proportional to the square root of the density. The higher the density the lower the speed. A little reasoning will lead to the obvious fact that if a material is more dense, then the mass per unit volume is obviously greater, which implies that the acceleration of any part of the material under application of a force will be less than in a lower density material. In addition, the force producing this acceleration will be due to the stiffness quality of the material. The greater the stiffness the larger the force. How the gross error stated above has found its way into elementary physics texts is beyond me. Perhaps it may have something to do with the Earth and atmosphere modules that seem to be 'hot' topics at the moment, rather than a simple application of Newton II. What amazes me is that if one takes lead and aluminium (not the most uncommon of materials), we find that vAl approx 5000 m s-1 and vlead approx 2000 m s-1. Yet lead is about four times as dense as aluminium! (Who is vetting these books, or is the National Curriculum ignorant of the real world?) Whilst on this subject it seems apparently obvious that a liquid cannot withstand a shear force (it collapses), which is why transverse waves do not travel through the liquid core. Is this simple explanation mentioned? However, in the solid region v = (G/ρ)1/2 where G is the shear modulus - which accounts for the velocity difference compared with compression waves. John Severn George Abbot School, Surrey, UK Bond is back Further to recent correspondence, it is always better for Bond to throw away both of his shoes at once. This will give him maximum velocity on the frictionless ice. Throwing the shoes separately will never match it. This assumes that each shoe is thrown with identical, maximum, effort in either situation. Edmonds [1] is correct to surmise, 'These subtle differences must come from momentum being linearly related to the

  10. Institute news

    Science.gov (United States)

    1999-11-01

    : Heriot-Watt University 4 Nov: Strathclyde University 17 Nov: York University 24 Nov: Bristol University 1 Dec: Open University 7 Dec: Kent University 14 Dec: Cardiff University 15 Dec: University of Wales, Swansea 24 Jan: Reading University 10 Feb: Abingdon School 16 Feb: Plymouth University 2 Mar: Sheffield University 7 Mar: CLRC Daresbury Laboratory 8 Mar: Liverpool University 9 Mar: Manchester 10 Mar: Lancaster University 15 Mar: Surrey University 16 Mar: Brighton University 17 Mar: St Vincent College, Gosport 22 Mar: Leeds University 23 Mar: Loughborough Grammar School 24 Mar: Oakham School 30 Mar: St Peter's School, Wolverhampton 18 May: University of Hertfordshire 11 Jul: Science Museum 12 Jul: Royal Institution The assistance of the Engineering and Physical Sciences Research Council, CLRC Daresbury Laboratory and DERA Malvern is acknowledged in staging this year's events. Courses, lectures and competitions `Physics in perspective', the study course for sixth-formers and college students, will take place in London on 6 - 8 February 2000, offering insights into many different aspects of physics. The programme commences during the afternoon of Sunday 6 February at King's College London with a Balloon debate, followed by Brian O'Rourke's talk on the `Physics of Formula 1 cars'. On Monday 7 February at the Royal Institution, John Avison (former Honorary Editor of Physics Education) will develop the `Thinking physics' theme by presenting the audience with varied topics in an unusual and challenging way. The second talk of the afternoon, by Professor Roy Sambles, will cover `Lasers, light and liquid crystals'. On the final day (Tuesday 8 February), again at the Royal Institution, Sara Ellison will lead the audience in `Heavenly pursuits', whilst later Dr Colin Wright will entertain with `Juggling - theory and practice'. Futher information and bookings for the course can be made by contacting Mrs Leila Solomon at The Institute of Physics, 76 Portland Place, London W1N 3DH

  11. Translation and Creative Writing: An Interview with Professor Margaret Rogers

    Directory of Open Access Journals (Sweden)

    Ruzbeh Babaee

    2016-01-01

    Full Text Available Introduction This interview was conducted with Emerita Professor Margaret Rogers with the aim of providing a brief but informative summary of the relationship between translation and creative writing. Emerita Professor Rogers is in the Centre for Translation Studies, School of English and Languages, University of Surrey, UK. She is also the founder of Terminology Network at the Institute of Translation and Interpreting in the UK. Professor Rogers introduced creative writing into the translation curriculum some 10 years ago at her own university.   The Interview   RB[1]: Do you believe in a theory of translation? MR[2]: There are many ways of trying to understand and, where we can, explain translation in all its guises, loci and times. To talk about ‘a theory’ in this context doesn’t help much. There are many different approaches to the academic study of translation: rather simply put, the particular approach which we choose to adopt may depend on our object of study (e.g. literary translation or specialised translation, what we want to find out about this (e.g. are we interested in product or process, in a historical or contemporary perspective, what resources we have available (e.g. a fully funded research team or a solo effort and so on. Many projects are interdisciplinary—this has long been recognised—and translation scholars are becoming much more resourceful in identifying, adopting and adapting relevant approaches from intersecting disciplines such as comparative literature, cultural studies, history, linguistics, philosophy, psychology and sociology. Some scholars are now advocating a problem-based approach. In any research project it is important to establish how the problem/phenomenon/issue which has been identified as the focus of the study can be tackled. For this, in an empirical study a method is crucial: in translation studies this is rarely something that can be picked off the shelf and is often a contribution to the