Sample records for surge follicular phase

  1. Developmental programming: Prenatal BPA treatment disrupts timing of LH surge and ovarian follicular wave dynamics in adult sheep

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    Veiga-Lopez, A.; Beckett, E.M.; Abi Salloum, B. [Department of Pediatrics, University of Michigan, Ann Arbor, MI (United States); Ye, W. [Department of Biostatistics, University of Michigan, Ann Arbor, MI (United States); Padmanabhan, V., E-mail: [Department of Pediatrics, University of Michigan, Ann Arbor, MI (United States); The Reproductive Sciences Program, University of Michigan, Ann Arbor, MI (United States)


    Developmental exposure to BPA adversely affects reproductive function. In sheep, prenatal BPA treatment induces reproductive neuroendocrine defects, manifested as LH excess and dampened LH surge and perturbs early ovarian gene expression. In this study we hypothesized that prenatal BPA treatment will also disrupt ovarian follicular dynamics. Pregnant sheep were treated from days 30 to 90 of gestation with 3 different BPA doses (0.05, 0.5, or 5 mg/kg BW/day). All female offspring were estrus synchronized and transrectal ultrasonography was performed daily for 22 days to monitor ovarian follicular and corpora lutea dynamics. Blood samples were collected to assess preovulatory hormonal changes and luteal progesterone dynamics. Statistical analysis revealed that the time interval between the estradiol rise and the preovulatory LH surge was shortened in the BPA-treated females. None of the three BPA doses had an effect on corpora lutea, progestogenic cycles, and mean number or duration of ovulatory and non-ovulatory follicles. However, differences in follicular count trajectories were evident in all three follicular size classes (2–3 mm, 4–5 mm, and ≥ 6 mm) of prenatal BPA-treated animals compared to controls. Number of follicular waves tended also to be more variable in the prenatal BPA-treated groups ranging from 2 to 5 follicular waves per cycle, while this was restricted to 3 to 4 waves in control females. These changes in ovarian follicular dynamics coupled with defects in time interval between estradiol rise and preovulatory LH release are likely to lead to subfertility in prenatal BPA-treated females. - Highlights: • Prenatal BPA shortens interval between estradiol rise and preovulatory LH surge. • Prenatal BPA affects follicular count trajectory and follicular wave occurrence. • Prenatal BPA does not affect ovulatory rate and progesterone dynamics.

  2. Feedback actions of estradiol on GnRH secretion during the follicular phase of the estrous cycle. (United States)

    Karsch, F J; Evans, N P


    The pattern of GnRH secretion during the follicular phase of the estrous cycle of sheep is characterized by an initial marked change in episodic secretion (increased frequency and decreased amplitude) followed by a massive and sustained discharge-the preovulatory GnRH surge. Studies employing a physiological model for the follicular phase have revealed that estradiol has profound and complex feedback effects on GnRH release during the preovulatory period. These include both quantitative effects on pulses (stimulation of frequency, inhibition of amplitude) and qualitative effects (altering pulse shape, stimulating interpulse secretion), in addition to inducing a preovulatory GnRH surge. In stimulating the surge, estradiol causes a highly characteristic change in the minute-to-minute pattern of GnRH in hypophyseal portal blood. Initially, a strictly episodic pattern gives way to one in which GnRH is consistently elevated between pulses. Then, following enhancement of both pulsatile and interpulse components, GnRh becomes extremely high and variable for the majority of the surge. From this point, a regular and well organized pulse pattern is not apparent. The characteristic time course of GnRH at surge onset provides insight into possible mechanistic changes in the GnRH neurosecretory system. Such changes include quantitative and qualitative alterations in the pulse generating mechanism, recruitment of a surge specific population of GnRH neurones, morphologic alterations in GnRH neurones and neighboring cells, and changes in efficiency or route of delivery of GnRH from its site of release to the portal vasculature. These possibilities, while untested and speculative, provide a conceptual framework for future research.

  3. Cytological image of the endometrium in cows in follicular and luteal phases of the ovarian cycle and in cows with follicular and luteal ovarian cysts

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    Brodzki Piotr


    Full Text Available The experiment was conducted on 30 Holstein-Friesian cows: 10 cows in the follicular phase of the cycle and in the luteal phase 10 d later, 10 cows with follicular cysts, and 10 with luteal cysts. The presence of the ovarian structures was confirmed by ultrasonography. Serum levels of progesterone and 17β-oestradiol were tested with ELISA. Samples for cytological examination were collected from the uterus of all cows using a cytological brush. Following staining, the smears were evaluated in terms of quality and percentages of endometrial cells. In the follicular phase of the oestrous cycle, cells of type A - superficial cells (64.6 ± 4.48 were proportionally the largest group of cells. Cells of type C - basal cells (19.8 ± 2.75 were also present. In the luteal phase, the highest percentage of cells was of type B - intermediate cells (76.9 ± 4.26. When follicular cysts were present on the ovaries, the cytology resembled the follicular phase of the cycle, but with many younger type C cells (33.1 ± 4.11. In the case of luteal cysts on the ovaries, the cytology was similar to that of the luteal phase of the cycle, however with a lower percentage of type B cells (58.1 ± 5.71, and a slightly higher percentage of the other types. The differences in the cytological image of the uterus when different ovarian structures are present, depend on the hormonal activity of those structures. Due to the lack of literature data, the results of the study are important as a model, and may substantially facilitate identification of phases of the oestrus cycle, or the pathologies described, as well as indicate the current status of the endometrium

  4. Change of anti-Mullerian-hormone levels during follicular phase in PCOS patients. (United States)

    Köninger, A; Koch, L; Enekwe, A; Birdir, C; Kasimir-Bauer, S; Kimmig, R; Strowitzki, T; Schmidt, B


    Anti-Mullerian-hormone (AMH) does not seem to fluctuate significantly during the menstrual cycle in healthy women. However, little is known about cycle fluctuations of AMH levels in patients with polycystic ovarian syndrome (PCOS). The purpose of this study was to examine AMH fluctuations during the follicular phase in PCOS patients receiving antiestrogens or recombinant follicle-stimulating hormone (FSH). About 40 PCOS patients diagnosed according to Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group 2003 and 19 controls were prospectively enrolled. PCOS patients received either antiestrogens or recombinant FSH for monoovulation induction and controls received antiestrogens. AMH levels were determined (1) between the 2nd and the 5th day of follicular phase and (2) when a single large dominant follicle ≥18 mm had appeared. Our study shows that AMH levels do not change during follicular development in controls as well as in PCOS patients with AMH levels PCOS patients with AMH levels ≥5 ng/ml, AMH declines significantly during follicular development (p PCOS patients without the influence of antiestrogens or exogenous FSH, because these interventions may lower AMH values in patients with high levels.

  5. MicroRNA Expression Profile in Bovine Granulosa Cells of Preovulatory Dominant and Subordinate Follicles during the Late Follicular Phase of the Estrous Cycle. (United States)

    Gebremedhn, Samuel; Salilew-Wondim, Dessie; Ahmad, Ijaz; Sahadevan, Sudeep; Hossain, Md Munir; Hoelker, Michael; Rings, Franca; Neuhoff, Christiane; Tholen, Ernst; Looft, Christian; Schellander, Karl; Tesfaye, Dawit


    In bovine, ovarian follicles grow in a wave-like fashion with commonly 2 or 3 follicular waves emerging per estrous cycle. The dominant follicle of the follicular wave which coincides with the LH-surge becomes ovulatory, leaving the subordinate follicles to undergo atresia. These physiological processes are controlled by timely and spatially expressed genes and gene products, which in turn are regulated by post-transcriptional regulators. MicroRNAs, a class of short non-coding RNA molecules, are one of the important posttranscriptional regulators of genes associated with various cellular processes. Here we investigated the expression pattern of miRNAs in granulosa cells of bovine preovulatory dominant and subordinate follicles during the late follicular phase of bovine estrous cycle using Illumina miRNA deep sequencing. In addition to 11 putative novel miRNAs, a total of 315 and 323 known miRNAs were detected in preovulatory dominant and subordinate follicles, respectively. Moreover, in comparison with the subordinate follicles, a total of 64 miRNAs were found to be differentially expressed in preovulatory dominant follicles, of which 34 miRNAs including the miR-132 and miR-183 clusters were significantly enriched, and 30 miRNAs including the miR-17-92 cluster, bta-miR-409a and bta-miR-378 were significantly down regulated in preovulatory dominant follicles. In-silico pathway analysis revealed that canonical pathways related to oncogenesis, cell adhesion, cell proliferation, apoptosis and metabolism were significantly enriched by the predicted target genes of differentially expressed miRNAs. Furthermore, Luciferase reporter assay analysis showed that one of the differentially regulated miRNAs, the miR-183 cluster miRNAs, were validated to target the 3'-UTR of FOXO1 gene. Moreover FOXO1 was highly enriched in granulosa cells of subordinate follicles in comparison with the preovulatory dominant follicles demonstrating reciprocal expression pattern with miR-183

  6. MicroRNA Expression Profile in Bovine Granulosa Cells of Preovulatory Dominant and Subordinate Follicles during the Late Follicular Phase of the Estrous Cycle.

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    Samuel Gebremedhn

    Full Text Available In bovine, ovarian follicles grow in a wave-like fashion with commonly 2 or 3 follicular waves emerging per estrous cycle. The dominant follicle of the follicular wave which coincides with the LH-surge becomes ovulatory, leaving the subordinate follicles to undergo atresia. These physiological processes are controlled by timely and spatially expressed genes and gene products, which in turn are regulated by post-transcriptional regulators. MicroRNAs, a class of short non-coding RNA molecules, are one of the important posttranscriptional regulators of genes associated with various cellular processes. Here we investigated the expression pattern of miRNAs in granulosa cells of bovine preovulatory dominant and subordinate follicles during the late follicular phase of bovine estrous cycle using Illumina miRNA deep sequencing. In addition to 11 putative novel miRNAs, a total of 315 and 323 known miRNAs were detected in preovulatory dominant and subordinate follicles, respectively. Moreover, in comparison with the subordinate follicles, a total of 64 miRNAs were found to be differentially expressed in preovulatory dominant follicles, of which 34 miRNAs including the miR-132 and miR-183 clusters were significantly enriched, and 30 miRNAs including the miR-17-92 cluster, bta-miR-409a and bta-miR-378 were significantly down regulated in preovulatory dominant follicles. In-silico pathway analysis revealed that canonical pathways related to oncogenesis, cell adhesion, cell proliferation, apoptosis and metabolism were significantly enriched by the predicted target genes of differentially expressed miRNAs. Furthermore, Luciferase reporter assay analysis showed that one of the differentially regulated miRNAs, the miR-183 cluster miRNAs, were validated to target the 3'-UTR of FOXO1 gene. Moreover FOXO1 was highly enriched in granulosa cells of subordinate follicles in comparison with the preovulatory dominant follicles demonstrating reciprocal expression pattern

  7. Short-term administration of antivascular endothelial growth factor antibody in the late follicular phase delays follicular development in the rhesus monkey. (United States)

    Zimmermann, R C; Xiao, E; Husami, N; Sauer, M V; Lobo, R; Kitajewski, J; Ferin, M


    Indirect evidence in the nonhuman primate and human suggests that angiogenesis and regulators of angiogenesis such as vascular endothelial growth factor (VEGF) may play an active role in cyclic folliculogenesis. Indeed, the follicle selected for maturation and ovulation possesses a denser microvascular network, and VEGF messenger ribonucleic acid and its protein have been identified in granulosa cells of the developing follicle during the mid- and late follicular phases, with a more intense signal in the mature follicle. The objective of this study was to obtain direct evidence in the nonhuman primate for an active role of VEGF in follicular growth and maturation by studying the effect of VEGF-blocking antibodies in this process. After documenting two normal ovulatory cycles, female rhesus monkeys (n = 7) received iv injections of anti-VEGF antibodies (0.5 mg) twice on successive days in the late follicular phase. Three monkeys also received nonspecific goat IgG (0.5 mg) twice on successive days in the late follicular phase. Daily measurements of estradiol, progesterone, LH, and FSH were obtained during the two control cycles, the anti-VEGF treatment and posttreatment cycles, and the IgG treatment cycle. Anti-VEGF antibody administration significantly lengthened the follicular phase in six of seven monkeys to 17.8 +/- 1.7 vs. 10.0 +/- 0.7 and 9.8 +/- 0.6 in control cycles and 10.7 +/- 0.3 days (mean +/- SE) in IgG-treated cycles. The expected late follicular phase rise in estradiol, as documented in the control cycles (day 0, 96.1 +/- 6.0; day 1, 125.5 +/- 20.0; day 2, 165.5 +/- 24.9; day 3, 183.8 +/- 11.0 pg/mL), was interrupted by anti-VEGF antibody treatment (99.3 +/- 5.0, day 0, preinjection control) to 63.3 +/- 12.2 (day 1), 48.5 +/- 8.7 (day 2), and 57.6 +/- 9.0 (day 3). Mean FSH levels were significantly increased by day 2 of anti-VEGF antibody treatment. After a variable delay, estradiol concentrations increased to reach a preovulatory peak in all anti

  8. CRP at early follicular phase of menstrual cycle can cause misinterpretation for cardiovascular risk assessment. (United States)

    Gursoy, Asli Yarci; Caglar, Gamze Sinem; Kiseli, Mine; Pabuccu, Emre; Candar, Tuba; Demirtas, Selda


    C-reactive protein (CRP) is a well-known marker of inflammation and infection in clinical practice. This study is designed to evaluate CRP levels in different phases of menstrual cycle, which might end up with misleading conclusions especially when used for cardiovascular risk assessment. Twenty-seven women were eligible for the cross-sectional study. Venous blood samples from each participant were collected twice during the menstrual cycle. The first sampling was held at 2nd to 5th days of the menstrual cycle for FSH, estradiol, CRP, and sedimentation, and the second was done at 21st to 24th days of the menstrual cycle for measurement of progesterone, CRP, and sedimentation values. CRP values were significantly higher in the early follicular phase compared to luteal phase (1.8 mg/L [0.3-7.67] vs. 0.7 mg/L [0.1-8.3], p menstrual cycle, sedimentation rate was similar (12.1 ± 6.7 vs. 12.3 ± 7.7; p = 0.717, respectively). CRP levels in early follicular phase of the menstrual cycle (menstruation) are significantly higher than CRP levels in luteal phase of the same cycle. In reproductive age women, detection of CRP for cardiovascular risk assessment during menstruation might not be appropriate.

  9. Circadian variation of sleep during the follicular and luteal phases of the menstrual cycle. (United States)

    Shechter, Ari; Varin, France; Boivin, Diane B


    Women experience insomnia more frequently than men. Menstrual cycle changes in reproductive hormones and circadian rhythms may contribute to sleep disruptions. Our aim, therefore, was to clarify the interaction between menstrual and circadian processes as it affects sleep. Participants entered the laboratory during the mid-follicular (MF) and mid-luteal (ML) phases of their menstrual cycle for an ultra-rapid sleep-wake cycle (URSW) procedure, consisting of 36 cycles of 60-min wake episodes alternating with 60-min nap opportunities. This procedure concluded with an ad libitum nap episode. Time-isolation suite. Eight unmedicated, physically and mentally healthy females with regular ovulatory menstrual cycles. N/A. Polysomnographic sleep from nocturnal sleep episodes and 60-min naps; subjective alertness; core body temperature (CBT); salivary melatonin; urinary estradiol; and urinary progesterone. Increased CBT values at night and decreased CBT amplitude were observed during ML compared to MF. Circadian phase of CBT and the circadian melatonin profile were unaffected by menstrual phase. All analyzed sleep parameters showed a circadian variation throughout the URSW procedure, with no menstrual phase differences observed for most, including slow wave sleep (SWS). The circadian variation of REM sleep duration, however, was sensitive to menstrual phase, with reduced REM sleep during ML at circadian phase 0 degrees and 30 degrees. Moderate but significant changes in REM sleep across the menstrual and circadian cycles were observed. These results support an interaction between circadian and menstrual processes in the regulation of REM sleep.

  10. The effects of serum concentration of androgens, LH and IGF1 in early follicular phase on follicular growth parameters and pregnancy rate

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    Zahra Raoofi


    Full Text Available Objective: Many studies have showed the role of androgens on the follicular maturation. The present study investigated the effect of serum concentration of androgens, LH and IGF1 in the early follicular phase on the results of the ovulation induction (I/O and intrauterine insemination (IUI cycles. Materials and methods: This prospective observational cross-sectional study was carried out in the infertility department of a university hospital in Tehran, Iran. The case’s selection was based on the inclusion and exclusion criteria and was nonrandomized. 59 patients under the age of 45 who were candidate for induction ovulation (I/O or intrauterine insemination were included. The inclusion criteria consist of infertility for at least one year and at least one open tube in HSG. Patients were excluded if they had polycystic ovary syndrome (PCOS or endometriosis. The serum concentration of androgens (testosterone, dehydroepiandrosterone and androstenedione, LH and IGF1 was measured on the third day of menstruation. Clomiphene and human menopausal gonadotropin (HMG were drugs of induction ovulation. Human chorionic gonadotropin (HCG was injected when there was at least one follicle with the size of (18 mm. IUI was done 36 h later for eligible patients and the relation of concentration of androgens, LH and IGF1 with follicular growth parameters and pregnancy rate was analyzed. Results: There was not any statistical significant link between the number and size of follicles with levels of free testosterone, dehydroepiandrosterone, androstenedione, IGF1 and LH. There was not any statistical significant link between the number of follicles in the ovaries and levels of testosterone (P = 0.090 and r = 0.223, dehydroepiandrosterone (P = 0.642 and r = 0.062 and androstenedione (P = 0.526 and r = 0.084, IGF1 (P = 0.470 and r = 0.096 and LH (P = 0.446 and r = 0.102. There was not any statistical significant link between the mean follicular

  11. Quiescent-phase evolution of a surge-type glacier: Black Rapids Glacier, Alaska, U.S.A. (United States)

    Heinrichs, T.A.; Mayo, L.R.; Echelmeyer, K.A.; Harrison, W.D.


    Black Rapids Glacier, a surge-type glacier in the Alaska Range, most recently surged in 1936-37 and is currently in its quiescent phase. Mass balance, ice velocity and thickness change have been measured at three to ten sites from 1972 to 1994. The annual speed has undergone cyclical fluctuations of as much as 45% about the mean speed. Ice thickness and surface slope did not change enough to cause the speed fluctuations through changes in ice deformation, which indicates that they are being driven by changes in basal motion. The behavior of Black Rapids Glacier during this quiescent phase is significantly different from that of Variegated Glacier, another well-studied surge-type glacier in Alaska. The present medial-moraine configuration of Black Rapids Glacier indicates that a surge could occur at any time. However, ice velocity data indicate that the next surge may not be imminent. We believe that there is little chance that the next surge will cross and dam the Delta River.

  12. Effect of Repeated Stress Treatments During the Follicular Phase and Early Pregnancy on Reproductive Performance of Gilts

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    Soede, N.M.; Roelofs, J.B.; Verheijen, R.J.E.; Schouten, W.G.P.; Hazeleger, W.; Kemp, B.


    In pig husbandry, stress is being considered an important cause of impaired reproductive performance. Therefore, an experiment was performed to quantify effects of repeated stressors during the follicular phase and/or during early pregnancy on reproductive performance of gilts. Eighty-one cyclic

  13. Analysis of human mammary fibroadenoma by Ki-67 index in the follicular and luteal phases of menstrual cycle. (United States)

    Rego, M F; Navarrete, M A L H; Facina, G; Falzoni, R; Silva, R; Baracat, E C; Nazario, A C P


    Fibroadenoma is the most common benign mammary condition among women aged 35 or younger. Expression of Ki-67 antigen has been used to compare proliferative activity of mammary fibroadenoma epithelium in the follicular and luteal phases of the menstrual cycle. Ninety eumenorrheic women were selected for tumour excision; they were assigned to either of the two groups, according to their phase of menstrual cycle. At the end of the study, 75 patients with 87 masses were evaluated by epithelial cell Ki-67 expression, blind (no information given concerning group to which any lesion belonged). Both groups were found to be homogeneous relative to age, menarche, body mass index, previous gestation, parity, breastfeeding, number of fibroadenomas, family history of breast cancer and tabagism. Median tumour size was 2.0 cm and no relationship between proliferative activity and nodule diameter was observed. No typical pattern was observed in the expression of Ki-67 in distinct nodules of the same patient. Average values for expression of Ki-67 (per 1000 epithelial cells) in follicular and luteal phases were 27.88 and 37.88, respectively (P = 0.116). Our findings revealed that proliferative activities in the mammary fibroadenoma epithelium did not present a statistically significant difference in the follicular and luteal phases. The present study contributes to clarifying that fibroadenoma is a neoplasm and does not undergo any change in the proliferative activity during the menstrual cycle.

  14. Alterations in transcript abundance of bovine oocytes recovered at growth and dominance phases of the first follicular wave

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    Kanitz Wilhelm


    Full Text Available Abstract Background Oocyte developmental competence is highly affected by the phase of ovarian follicular wave. Previous studies have shown that oocytes from subordinate follicles recovered at growth phase (day 3 after estrus are developmentally more competent than those recovered at dominance phase (day 7 after estrus. However, the molecular mechanisms associated with these differences are not well elucidated. Therefore, the objective of this study was to investigate transcript abundance of bovine oocytes retrieved from small follicles at growth and dominance phases of the first follicular wave and to identify candidate genes related to oocyte developmental competence using cDNA microarray. Results Comparative gene expression analysis of oocytes from growth and dominance phases and subsequent data analysis using Significant Analysis of Microarray (SAM revealed a total of 51 differentially regulated genes, including 36 with known function, 6 with unknown function and 9 novel transcripts. Real-time PCR has validated 10 transcripts revealed by microarray analysis and quantified 5 genes in cumulus cells derived from oocytes of both phases. The expression profile of 8 (80% transcripts (ANAXA2, FL396, S100A10, RPL24, PP, PTTG1, MSX1 and BMP15 was in agreement with microarray data. Transcript abundance of five candidate genes in relation to oocyte developmental competence was validated using Brilliant Cresyl Blue (BCB staining as an independent model. Furthermore, localization of mRNA and protein product of the candidate gene MSX1 in sections of ovarian follicles at days 0, 1, 3 and 7 of estrous cycle showed a clear fluorescent signal in both oocytes and cumulus cells with higher intensity in the former. Moreover, the protein product was detected in bovine oocytes and early cleavage embryos after fertilization with higher intensity around the nucleus. Conclusion This study has identified distinct sets of differentially regulated transcripts between

  15. Surge-type glaciers: controls, processes and distribution


    Sevestre, Heïdi


    Glacier surging is an internally triggered instability. Surge-type glaciers periodically alternate between long periods of slow flow (the quiescent phase) and short periods of fast flow (the surge phase). Surging yields down-glacier transport of mass and often results in large and sudden glacier advances.The surging phenomenon has always challenged the notion of normality in glacier flow dynamics. The mechanisms of surging remain poorly understood. Observation of different surge behaviors acr...

  16. Follicular and luteal phase characteristics following early cessation of gonadotrophin-releasing hormone agonist during ovarian stimulation for in-vitro fertilization

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    J.S.E. Laven (Joop); M.J.C. Eijkemans (René); B.C.J.M. Fauser (Bart); N.G.M. Beckers (Nicole)


    textabstractGonadotrophin-releasing hormone agonists (GnRHa) are widely used in in-vitro fertilization (IVF) for the prevention of a premature rise in luteinizing hormone (LH) concentrations. However, the administration of GnRHa during the follicular phase may also impa

  17. (abstract) Observation by Clementine of a Hugh Opposition Surge on the Moon at Very Small Solar Phase Angles (United States)

    Buratti, B. J.; Wang, M. C.


    The Clementine mission enabled the first quantative observations of the Moon at very small solar phase angles. It is well established from Earth-based observations that the Moon exhibits a non-linear increase in brightness as its face becomes fully illuminated to a terrestrial observer. Because the models of the opposition effect are sensitive indicators of surfical compaction state and particle size, observations at small solar phase angles are important to obtain. A recent model for optical coherent backscatter seeks to explain a narrow opposition spike at very small phase angles (Moon's surface at phase angles less than 0.5(deg) (the minimum phase angle observable from Earth due to the Moon's angular size) were obtained by the Clementine spacecraft. Our analysis of these images shows the moon exhibits a surge in brightness of approximately 20% below 0.25(deg), comparable to the values observed on icy satellites. No color dependence was detected in the lunar phase curve below 2 degrees.

  18. Follicular dermographism. (United States)

    Shelley, W B; Shelley, E D


    Four patients who complained of an inexplicable pruritus of several weeks to several years in duration are presented. General medical studies were unremarkable and the skin was normal except for erythematous papular lesions at sites recently scratched. The skin changes could be reproduced by multiple firm strokes with the broad edge of a tongue blade. The transitory, discrete, follicular, urticarial papules so elicited have been labeled by us as follicular dermographism. It is an entity to be distinguished from cholinergic and aquagenic urticaria. We postulate that follicular dermographism occurs during periods of transient antigenemia. At such times, the frictional force of scratching or the tongue blade test releases antigen from the blood stream to trigger focal urticaria at sites of high density mast cells, namely around the hair follicle. Hydroxyzine is an effective therapy.

  19. Anomalous Surge of the White-Light Corona at the Onset of the Declining Phase of Solar Cycle 24 (United States)

    Lamy, P.; Boclet, B.; Wojak, J.; Vibert, D.


    In late 2014, when the current Solar Cycle 24 entered its declining phase, the white-light corona as observed by the LASCO-C2 coronagraph underwent an unexpected surge that increased its global radiance by 60%, reaching a peak value comparable to the peak values of the more active Solar Cycle 23. A comparison of the temporal variation of the white-light corona with the variations of several indices and proxies of solar activity indicate that it best matches the variation of the total magnetic field. The daily variations point to a localized enhancement or bulge in the electron density that persisted for several months. Carrington maps of the radiance and of the HMI photospheric field allow connecting this bulge to the emergence of the large sunspot complex AR 12192 in October 2014, the largest since AR 6368 observed in November 1990. The resulting unusually high increase of the magnetic field and the distortion of the neutral sheet in a characteristic inverse S-shape caused the coronal plasma to be trapped along a similar pattern. A 3D reconstruction of the electron density based on time-dependent solar rotational tomography supplemented by 2D inversion of the coronal radiance confirms the morphology of the bulge and reveals that its level was well above the standard models of a corona of the maximum type, by typically a factor of 3. A rather satisfactory agreement is found with the results of the thermodynamic MHD model produced by Predictive Sciences, although discrepancies are noted. The specific configuration of the magnetic field that led to the coronal surge resulted from the interplay of various factors prevailing at the onset of the declining phase of the solar cycles, which was particularly efficient in the case of Solar Cycle 24.

  20. Assessment of quantitative and qualitative changes of proteoglycans and glycosaminoglycans in normal breast tissue during the follicular and luteal phases of the menstrual cycle. (United States)

    Júnior, J A Dos Santos; de Lima, C R; Michelacci, Y M C da Silva; Nazário, A C Pinto


    The effect of sex hormones on extracellular matrix compounds, such as proteoglycans (PGs) and glycosaminoglycans (GAGs), in mammary tissue remains poorly understood. The elucidation of extracellular matrix component functions could clarify pathophysiological conditions, such as cyclical mastalgia (breast pain). The authors examined the quantitative and qualitative changes of PGs and GAGs in normal breast tissue during the follicular and luteal phases of the menstrual cycle. Twenty-eight eumenorrheic patients with benign breast nodules were divided into groups: Group A included 15 follicular patients and Group B included 13 luteal phase patients. Breast tissue adjacent to the nodules was biochemically analyzed to evaluate the types and concentrations of PGS and GAGs. The distribution of proteoglycans during the menstrual cycle was analyzed with immunofluorescence. PG concentrations were elevated (p < 0.01) during the luteal phase compared with the follicular phase, whereas the concentrations of GAGs did not differ significantly. Immunofluorescence revealed that decorin was mainly found in the intralobular stroma. PG concentrations were elevated during the luteal phase, likely due to the influence of sex hormones on macromolecular synthesis. The PG decorin was observed in normal breast tissue in the intralobular stroma. Although the concentration of GAGs, including dermatan and heparan sulfate, varied cyclically, the differences were not significant.

  1. Cortisol interferes with the estradiol-induced surge of luteinizing hormone in the ewe. (United States)

    Wagenmaker, Elizabeth R; Breen, Kellie M; Oakley, Amy E; Pierce, Bree N; Tilbrook, Alan J; Turner, Anne I; Karsch, Fred J


    Two experiments were conducted to test the hypothesis that cortisol interferes with the positive feedback action of estradiol that induces the luteinizing hormone (LH) surge. Ovariectomized sheep were treated sequentially with progesterone and estradiol to create artificial estrous cycles. Cortisol or vehicle (saline) was infused from 2 h before the estradiol stimulus through the time of the anticipated LH surge in the artificial follicular phase of two successive cycles. The plasma cortisol increment produced by infusion was approximately 1.5 times greater than maximal concentrations seen during infusion of endotoxin, which is a model of immune/inflammatory stress. In experiment 1, half of the ewes received vehicle in the first cycle and cortisol in the second; the others were treated in reverse order. All ewes responded with an LH surge. Cortisol delayed the LH surge and reduced its amplitude, but both effects were observed only in the second cycle. Experiment 2 was modified to provide better control for a cycle effect. Four treatment sequences were tested (cycle 1-cycle 2): vehicle-vehicle, cortisol-cortisol, vehicle-cortisol, cortisol-vehicle. Again, cortisol delayed but did not block the LH surge, and this delay occurred in both cycles. Thus, an elevation in plasma cortisol can interfere with the positive feedback action of estradiol by delaying and attenuating the LH surge.

  2. Heterogeneity in Karakoram glacier surges (United States)

    Quincey, Duncan J.; Glasser, Neil F.; Cook, Simon J.; Luckman, Adrian


    Many Karakoram glaciers periodically undergo surges during which large volumes of ice and debris are rapidly transported downglacier, usually at a rate of 1-2 orders of magnitude greater than during quiescence. Here we identify eight recent surges in the region and map their surface velocities using cross-correlation feature tracking on optical satellite imagery. In total, we present 44 surface velocity data sets, which show that Karakoram surges are generally short-lived, lasting between 3 and 5 years in most cases, and have rapid buildup and relaxation phases, often lasting less than a year. Peak velocities of up to 2 km a-1 are reached during summer months, and the surges tend to diminish during winter months. Otherwise, they do not follow a clearly identifiable pattern. In two of the surges, the peak velocity travels down-ice through time as a wave, which we interpret as a surge front. Three other surges are characterized by high velocities that occur simultaneously across the entire glacier surface, and acceleration and deceleration are close to monotonic. There is also no consistent seasonal control on surge initiation or termination. We suggest that the differing styles of surge can be partly accounted for by individual glacier configurations and that while some characteristics of Karakoram surges are akin to thermally controlled surges elsewhere (e.g., Svalbard), the dominant surge mechanism remains unclear. We thus propose that these surges represent a spectrum of flow instabilities and the processes controlling their evolution may vary on a glacier by glacier basis.

  3. A New Model for Predicting Dynamic Surge Pressure in Gas and Drilling Mud Two-Phase Flow during Tripping Operations

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    Xiangwei Kong


    Full Text Available Investigation of surge pressure is of great significance to the circulation loss problem caused by unsteady operations in management pressure drilling (MPD operations. With full consideration of the important factors such as wave velocity, gas influx rate, pressure, temperature, and well depth, a new surge pressure model has been proposed based on the mass conservation equations and the momentum conservation equations during MPD operations. The finite-difference method, the Newton-Raphson iterative method, and the fourth-order explicit Runge-Kutta method (R-K4 are adopted to solve the model. Calculation results indicate that the surge pressure has different values with respect to different drill pipe tripping speeds and well parameters. In general, the surge pressure tends to increase with the increases of drill pipe operating speed and with the decrease of gas influx rate and wellbore diameter. When the gas influx occurs, the surge pressure is weakened obviously. The surge pressure can cause a significant lag time if the gas influx occurs at bottomhole, and it is mainly affected by pressure wave velocity. The maximum surge pressure may occur before drill pipe reaches bottomhole, and the surge pressure is mainly affected by drill pipe operating speed and gas influx rate.

  4. Two-phase simulations of the full load surge in Francis turbines (United States)

    Wack, J.; Riedelbauch, S.


    At off-design conditions, Francis turbines experience cavitation which may reduce the power output and can cause severe damage in the machine. Certain conditions can cause self-excited oscillations of the vortex rope in the draft tube at full load operating point. For the presented work, two-phase simulations are carried out at model scale on a domain ranging from the inlet of the spiral case to the outlet of the draft tube. At different locations, wall pressure measurements are available and compared to the simulation results. Furthermore, the dynamics of the cavity volume in the draft tube cone and at the trailing edge of the runner blades are investigated by comparing with high speed visualization. To account for the selfexcited behaviour, proper boundary conditions need to be set. In this work, the focus lies on the treatment of the boundary condition at the inlet. In the first step, the dynamic behaviour of the cavity regions is investigated using a constant mass flow. Thereafter, oscillations of the total pressure and mass flow rate are prescribed using various frequencies and amplitudes. This methodology enables to examine the response of the cavity dynamics due to different excitations. It can be observed that setting a constant mass flow boundary condition is not suitable to account for the self-excited behaviour. Prescribing the total pressure has the result that the frequency of the vapour volume oscillation is the same as the frequency of the excitation signal. Contrary to that, for an excitation with a mass flow boundary condition, the response of the system is not equal to the excitation.

  5. Expression of calbindin-D9k and vitamin D receptor in the uterus of Egyptian buffalo during follicular and luteal phases. (United States)

    Emam, Mahmoud Abdelghaffar; Abouelroos, Mahmoud E A; Gad, Fatma A


    Uteri of mature Egyptian buffalo cows (5-10 years old) were collected at follicular (n=12) and luteal (n=16) phases of estrous cycle to investigate the expression of calbindin-D9k (CaPB-9k) and vitamin D receptor (VDR). This study was done using avidin-biotin immunohistochemistry method. In addition, blood levels of calcium (Ca), vitamin D3 (Vit D), estrogen (E2) and progesterone (P4) were measured. The immunohistochemical findings restricted the expressions of CaBP-9k and VDR to the luminal and glandular epithelia of the endometrium implicating the importance of CaBP-9K and VDR in the function of endometrial epithelium, especially the glandular one, in order to prepare a receptive uterus. On the other hand, the myometrium did not express CaBP-9k or VDR that denies the potential role of CaBP-9k and VDR in the uterine contractility during the estrous cycle of Egyptian buffalo. All of Ca, Vit D, and P4 blood levels significantly (P<0.05) increased during luteal phase however, blood level of E2 significantly (P<0.05) increased during follicular phase. The expressions of CaBP-9k and VDR in the uterus of Egyptian buffalo were significantly (P<0.05) higher during luteal (P4 dominant) phase than during the follicular (E2 dominant) phase indicating that P4 up-regulates the expressions of CaBP-9k and VDR. In view of these observations, this study represents the first characterization of CaBP-9K and VDR expression in the uterus of Egyptian buffalo and suggests the pivotal role of CaBP-9k and VDR in the uterine receptivity. Furthermore, it demonstrates the regulatory role of P4 for expressions of CaBP-9k and VDR in buffalo uterus. Copyright © 2016 Elsevier GmbH. All rights reserved.

  6. Phenobarbital blockade of the preovulatory luteinizing hormone surge: association with phase-advanced circadian clock and altered suprachiasmatic nucleus Period1 gene expression (United States)

    Legan, Sandra J.; Donoghue, Kathleen M.; Franklin, Kathleen M.; Duncan, Marilyn J.


    The suprachiasmatic nucleus (SCN) controls the timing of the preovulatory luteinizing hormone (LH) surge in laboratory rodents. Barbiturate administration during a critical period on proestrus delays the surge and prolongs the estrous cycle 1 day. Because a nonphotic timing signal (zeitgeber) during the critical period that phase advances activity rhythms can also induce the latter effect, we hypothesized that barbiturates delay the LH surge by phase-advancing its circadian timing signal beyond the critical period. In experiment 1, locomotor rhythms and estrous cycles were monitored in hamsters for 2–3 wk preinjection and postinjection of vehicle or phenobarbital and after transfer to darkness at zeitgeber time (ZT) 6 on proestrus. Phenobarbital delayed estrous cycles in five of seven hamsters, which exhibited phase shifts that averaged twofold greater than those exhibited by vehicle controls or phenobarbital-injected hamsters with normal cycles. Experiment 2 used a similar protocol, but injections were at ZT 5, and blood samples for LH determination were collected from 1200 to 1800 on proestrus and the next day via jugular cannulae inserted the day before proestrus. Phenobarbital delayed the LH surge 1 day in all six hamsters, but it occurred at an earlier circadian time, supporting the above hypothesis. Experiment 3 investigated whether phenobarbital, like other nonphotic zeitgebers, suppresses SCN Period1 and Period2 transcription. Two hours postinjection, phenobarbital decreased SCN expression of only Period1 mRNA, as determined by in situ hybridization. These results suggest that phenobarbital advances the SCN pacemaker, governing activity rhythms and hormone release in part by decreasing its Period1 gene expression. PMID:19297538

  7. Svalbard surging glacier landsystems (United States)

    Lovell, Harold; Benn, Douglas; Lukas, Sven; Flink, Anne


    is characterised by large cross-fjord push moraines of fjord floor sediments with lobe-shaped debris flows on their distal slope, glacial lineations, dense rhombohedral networks of crevasse squeeze ridges, and eskers. Annual push moraines associated with the quiescent phase are also observed and are unique to the submarine record. The terrestrial record consists of large lateral moraine systems alongside the fjord which contain outer push ridges composed of shallow marine sediments and an inner zone of ice stagnation terrain. Eskers, flutes and large, sharp-crested crevasse fill ridges in dense networks are superimposed on this inner zone; the latter are similar in character to their submarine counterparts but typically higher. We suggest that these three landsystems broadly characterise the geomorphology of the vast majority of known Svalbard surge-type glaciers and may allow previously unknown surge-type glaciers to be identified, both in the field and from aerial photographs and sea floor imagery.

  8. Medvezhiy Glacier surge in 2011

    Directory of Open Access Journals (Sweden)

    V. M. Kotlyakov


    Full Text Available The paper presents results of monitoring of the Medvezhiy Glacier state for the period from its surge of 2001 to the last pulsation of 2011. This monitoring is performed based on the photographing made from the Russian section of the International Space Station. Features, used for prediction of the glacier last movement, are pointed out. The earlier determined characteristic property of the Medvezhiy Glacier change from a phase of recovering to that of its fast movement has been substantiated. Mean period of the glacier pulsations, estimated from observations for the last century, is 13.5 years. A surge of the glacier left tributary is recognized.

  9. Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled trial

    DEFF Research Database (Denmark)

    Salles, Gilles; Seymour, John Francis; Offner, Fritz


    Patients with follicular lymphoma can have long survival times, but disease progression typically occurs 3-5 years after initial treatment. We assessed the potential benefit of 2 years of rituximab maintenance after first-line treatment in patients with follicular lymphoma receiving a rituximab p...

  10. Follicular traction urticaria* (United States)

    Duman, Hatice; Topal, Ilteris Oguz; Kocaturk, Emek


    Inducible urticaria is a heterogeneous subgroup of chronic urticarias caused by a wide variety of environmental stimuli, such as exercise, cold, heat, pressure, sunlight, vibration, and water. A new term, follicular traction urticaria, was suggested as an unusual form of inducible urticarias. We report a patient who was diagnosed with follicular traction urticaria.

  11. Obinutuzumab in follicular lymphoma. (United States)

    Martinez-Calle, N; Figueroa-Mora, R; Villar-Fernandez, S; Marcos-Jubilar, M; Panizo, C


    The CD20 marker continues to be exploited as a therapeutic target for non-Hodgkin's lymphoma. Obinutuzumab is part of a new generation of anti-CD20 monoclonal antibodies, which are synthesized using molecular engineering technology, resulting in novel target epitopes and unprecedented optimization of antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis. Rituximab is the current gold standard for anti-CD20 therapy, yet despite outstanding results published over the past decade, many patients continue to relapse after anti-CD20 regimens. Obinutuzumab is slowly positioning itself in the treatment of CD20+ B-cell neoplasms. On the basis of favorable results from the phase III GADOLIN trial, obinutuzumab was recently approved by the U.S. Food and Drug Administration in combination with bendamustine followed by obinutuzumab maintenance, for the treatment of follicular lymphoma (FL) patients who relapsed or are refractory to a rituximab-containing regimen. Additional phase III trials are underway to test obinutuzumab as a first-line anti-CD20 agent in FL with good preliminary results (GALLIUM trial); thus, it is likely that obinutuzumab will soon achieve a first-line indication. It is plausible that obinutuzumab will replace rituximab as the gold standard for chemoimmunotherapy in FL, although some safety concerns still need to be resolved. This review will address the preclinical pharmacology and the main aspects of the clinical development of obinutuzumab for the treatment of FL.

  12. Icy satellites of Saturn: disk-integrated observations of the brightness opposition surge at low phase angles (United States)

    Kulyk, I.; Jockers, K.


    The surfaces of most atmosphereless bodies exhibit two interesting optical phenomena at small phase angles, namely a strong brightness increase and negative values of the degree of linear polarization. Of particular interest is the appearance a nonlinear growth of the surface brightness and a second narrow minimum of polarization at phase angles less than 1-3°. These features of brightness and polarization in the narrow phase angle range near opposition are called the photometric and polarimetric opposition effects. These phenomena have attracted increased attention from the perspective of theories of light scattering in random media and their application to the determination of properties of the upper optically active regolith layers on the atmosphereless bodies. However, up to now photometric and especially polarimetric observations conducted at small phase angles are rare. In order to enlarge the amount of available observational data we have conducted photopolarimetric observations of the major icy Saturnian satellites. The observations were performed at the 2m-telescope of the Bulgarian National Observatory with the Two-Channel Focal Reducer of the Bulgarian Academy of Sciences built at the Max-Planck-Institute for Solar System Science. This instrument incorporates a two-channel imaging polarimeter which can be used in coronagraph setup. The light of Saturn and its rings is almost fully absorbed by a black glass and its diffraction pattern is eliminated by a Lyot stop. The photopolarimeter records intensity and degree of polarization of the satellites in two colors simultaneously. In this study, we present the first results of the disk-integrated photometry of Enceladus, Tethys, Dione, and Rhea in the red (center wavelength 694 nm, FWHM 79 nm) and near-infrared (center wavelength 888.5 nm, FWHM 29 nm, methane absorption band) spectral bands at phase angles between 5.6° and 0.01°. The resulting magnitudes can be represented as a sum of two terms, one

  13. ART Outcomes in GnRH Antagonist Protocol (Flexible) and Long GnRH Agonist Protocol during Early Follicular Phase in Patients with Polycystic Ovary Syndrome: A Randomized Clinical Trial (United States)

    Mokhtar, Sara; Sadeghi, Mohammad Reza; Akhondi, Mohammad Mehdi; Zafardoust, Simin; Badenush, Bita; Fatemi, Farnaz; Nazari, Fattane; Kamali, Koorosh; Mohammadzade, Afsaneh


    Background: Since increased LH in the early follicular phase in PCOS patients especially in GnRH antagonist protocol could be associated with reduced oocyte quality and pregnancy and impared implantation. The current study was conducted to determine ART outcomes in GnRH antagonist protocol (flexible) and long GnRH agonist protocol and compare them with adding GnRH antagonist in GnRH antagonist (flexible) protocol during early follicular phase in patients with polycystic ovary syndrome undergoing ICSI. Methods: In this randomized clinical trial, 150 patients with polycystic ovary syndrome undergoing ICSI were enrolled from 2012 to 2014 and randomly assigned to receive either GnRH antagonist protocol during early and late follicular phase or GnRH antagonist protocol (flexible) or long GnRH agonist protocol. The clinical and laboratory pregnancy in three groups was determined and compared. In this context, the chi-square and Fisher's exact test and ANOVA were used for data analysis. Statistical significance was defined as p<0.05. Results: There was no statistically significant difference with respect to chemical pregnancy and clinical pregnancy between the three groups. Also, other indices such as number and quality of oocytes and embryos were alike. Conclusion: Totally, according to our results, GnRH antagonist protocol during early and late follicular phase and GnRH antagonist protocol (flexible) and long GnRH agonist protocol in patients with polycystic ovary syndrome undergoing ICSI are similarly effective and use of each one based on patients' condition and physicians' opinion could be considered. PMID:26913233

  14. Follicular penetration and targeting. (United States)

    Lademann, Jürgen; Otberg, Nina; Jacobi, Ute; Hoffman, Robert M; Blume-Peytavi, Ulrike


    In the past, intercellular penetration was assumed to be the most important penetration pathway of topically applied substances. First hints that follicular penetration needs to be taken into consideration were confirmed by recent investigations, presented during the workshop "Follicular Penetration and Targeting" at the 4th Intercontinental Meeting of Hair Research Societies", in Berlin 2004. Hair follicles represent an efficient reservoir for the penetration of topically applied substances with subsequent targeting of distinct cell populations, e.g., nestin-expressing follicular bulge cells. The volume of this reservoir can be determined by differential stripping technology. The follicular penetration processes are significantly influenced by the state of the follicular infundibulum; recent experimental investigations could demonstrate that it is essential to distinguish between open and closed hair follicles. Topically applied substances can only penetrate into open hair follicle. Knowledge of follicular penetration is of high clinical relevance for functional targeting of distinct follicular regions. Human hair follicles show a hair-cycle-dependent variation of the dense neuronal and vascular network. Moreover, during hair follicle cycling with initiation of anagen, newly formed vessels occur. Thus, the potential of nestin-expressing hair follicle stem cells to form neurons and blood vessels was investigated.

  15. Follicular occlusion tetrad

    Directory of Open Access Journals (Sweden)

    Vani Vasanth


    Full Text Available Follicular occlusion tetrad is a symptom complex consisting of four conditions having a similar pathophysiology. It includes Hidradenitis suppurativa, acne conglobata, dissecting cellulitis of the scalp and pilonidal sinus. The exact pathogenesis of this group of disease is unknown but evidence suggests that they share the same pathological process initiated by follicular occlusion in apocrine gland bearing areas. Though each of these conditions is commonly encountered singly, follicular occlusion tetrad as a symptom complex has been rarely reported in the literature.

  16. Medvezhiy Glacier surge in 2011


    V. M. Kotlyakov; L. V. Desinov


    The paper presents results of monitoring of the Medvezhiy Glacier state for the period from its surge of 2001 to the last pulsation of 2011. This monitoring is performed based on the photographing made from the Russian section of the International Space Station. Features, used for prediction of the glacier last movement, are pointed out. The earlier determined characteristic property of the Medvezhiy Glacier change from a phase of recovering to that of its fast movement has been substantiated...

  17. Influence of a low-carbohydrate diet on thermoregulatory responses to exercise in women during follicular and luteal phase of the menstrual cycle

    Directory of Open Access Journals (Sweden)

    I Pokora


    Full Text Available The aim of this study was to examine the effects of a low-carbohydrate diet on thermoregulatory responses to exercise in women during follicular (F and luteal (L phase of the menstrual cycle. Ten subjects performed a graded bicycle exercise in a thermoneutral environment (23oC, 52-60% relative humidity. Women were tested after consuming, for 3 days, a control diet (C: 60% carbohydrates, 20% fat, 20% protein and after that a low-carbohydrate diet (LCHO: 50% fat, 35% protein and 5% carbohydrates, in each phase of the menstrual cycle. Tympanic temperature (Tty, mean skin temperature (Tsk, electrical skin resistance (ESR, oxygen uptake (VO2, heart rate (HR as well as blood β-hydroxybutyrate acid (β-HB, glucose (Glu and lactate (LA concentrations were measured. On the basis of ESR, dynamics of sweating was estimated. No differences in Tty and Tsk were found between the C and LCHO during exercise tests. However, Tty was significantly higher during L than F phase. Delay time for sweating was shorter after LCHO (F: 10.8 vs 9.4 min, P<0.05, L: 9.9 vs 9.3 N.S., but temperature threshold for this reaction was unchanged (L: 37.22 vs 37.37 and F: 36.91 vs 36.94 oC. Sweating sensitivity was greater after LCHO during both F and L. Resting blood Glu and LA concentrations were similar in women after C and LCHO diet. Before exercise β-HB level was F: 0.45, L: 0.35 mM after LCHO and F: 0.08, L: 0.09 mM after C diet (P<0.05, respectively. At rest and during exercise HR was significantly higher after LCHO diet in women during F phase. In submaximal exercise loads VO2 after LCHO diet were significantly higher than after C diet in all women. It was concluded that the low-carbohydrate diet ingested by young women in both phases of the menstrual cycle have no effect on body temperature, however, it affects heat dissipation mechanism during exercise.

  18. Relationship between the size of the dominant follicle, vaginal electrical resistance, serum concentrations of oestradiol and progesterone and sexual receptivity during the follicular phase of the dromedary camel (Camelus dromedarius). (United States)

    Ghoneim, I M; Waheed, M M; Adam, Mohammed I; Al-Eknah, M M


    Thirteen dromedaries were used to study the relationship between the size of the dominant follicle, vaginal electrical resistance (VER), sexual receptivity, and serum concentrations of oestradiol-17β (E2) and progesterone (P4) throughout the follicular phase. On a daily basis, the animals experienced teasing with a vasectomised camel, trans-rectal ultrasound examination of the ovaries, and measurement of VER and blood collection for serum E2 and P4. Results revealed no significant differences between the mean VER in the animals that had a follicle of 5-10mm (group I, n=11), 11-15mm (group II, n=12) and 16-20mm (group III, n=13). The VER did not correlate with the follicular size. The E2 concentrations in the animals in groups II (60.14pg/ml) and III (66.52pg/ml) were significantly (Pdromedary camels.

  19. Coexisting state of surge and rotating stall in a two-stage axial flow compressor using a double-phase-locked averaging technique (United States)

    Sakata, Yuu; Ohta, Yutaka


    The interaction between surge and rotating stall in an axial flow compressor was investigated from the viewpoint of an unsteady inner flow structure. The aim of this study was to identify the key factor that determines the switching phenomenon of a surge cycle. The main feature of the tested compressor is a shock tube connected in series to the compressor outlet through a diaphragm, slits, and a concentric duplex pipe: this system allows surge and rotating stall to be generated by connecting the shock tube with the compressor, or enables the compression plane wave injection. The unsteady characteristics and the internal flow velocity fluctuations were measured in detail, and the stall cell structure was averaged and visualized along the movement of the operation point under a coexisting state of surge. A coefficient of the cell scale fluctuation was calculated using the result of the averaging, and it confirmed that the processes of inner flow structure change differed from each other according to the next cycle of the surge. The result suggests that the key factor that determines the next cycle is the transformation of the internal flow structure, particularly between the stall cell and the entire circumferential stall, in both the recovering and stalling processes.

  20. Follicular occlusion triad

    Directory of Open Access Journals (Sweden)

    Mittal R


    Full Text Available One 40-year female was diagnosed as a case of follicular occlusion triad (FOT as she had hidradenitis suppurativa, acne conglobata and perifolliculitis capitis abscedens et suffodiens since 7 years. Partial improvement occurred within 20 days of treatment with co-trimoxazole and haematinics but relapse occurred after 5 days of stopping antibiotics.

  1. Deep FIFO Surge Buffer (United States)

    Temple, Gerald; Siegel, Marc; Amitai, Zwie


    First-in/first-out (FIFO) temporarily stores short surges of data generated by data-acquisition system at excessively high rate and releases data at lower rate suitable for processing by computer. Size and complexity reduced while capacity enhanced by use of newly developed, sophisticated integrated circuits and by "byte-folding" scheme doubling effective depth and data rate.

  2. Deep FIFO Surge Buffer (United States)

    Temple, Gerald; Siegel, Marc; Amitai, Zwie


    First-in/first-out (FIFO) temporarily stores short surges of data generated by data-acquisition system at excessively high rate and releases data at lower rate suitable for processing by computer. Size and complexity reduced while capacity enhanced by use of newly developed, sophisticated integrated circuits and by "byte-folding" scheme doubling effective depth and data rate.

  3. Predicting Storm Surges: Chaos, Computational Intelligence, Data Assimilation, Ensembles

    NARCIS (Netherlands)

    Siek, M.B.L.A.


    Accurate predictions of storm surge are of importance in many coastal areas. This book focuses on data-driven modelling using methods of nonlinear dynamics and chaos theory for predicting storm surges. A number of new enhancements are presented: phase space dimensionality reduction, incomplete time

  4. 体外受精-胚胎移植晚卵泡期血清孕激素阈值确定%Threshold value of serum progestogen level during late follicular phase in IVF-ET cycle

    Institute of Scientific and Technical Information of China (English)

    吴霞; 谭晓珊


    目的:探讨体外受精-胚胎移植(IVF-ET)周期中晚卵泡期血清孕激素的参考阈值.方法:回顾性分析2007年2月~2010年11月在遵义医学院附属医院生殖中心行IVF-ET 436个周期的临床资料.根据4≤获卵数≤15或获卵数>15,将患者分为卵巢正常反应组及卵巢高反应组,以正常卵裂速度胚胎为效应指标,通过绘制ROC曲线,最终确定该生殖中心晚卵泡期血清孕激素的参考阈值.结果:ROC曲线显示,卵巢正常反应组晚卵泡期血清孕激素的参考阈值为4.95 nmol/L;卵巢高反应组晚卵泡期血清孕激素的参考阈值为5.95nmol/L.结论:该生殖中心卵巢正常反应组晚卵泡期血清P的参考阈值定为4.95nmol/L,卵巢高反应组晚卵泡期血清孕激素的参考阈值定为5.95 nmol/L.%Objective: To explore the reference threshold value of serum progestogen during late follicular phase in in vitro fertilization - embryo transfer ( FVF - ET) cycle. Methods: The clinical data of 436 patients who received IVF - ET cycles in the hospital from February 2007 to November 2010 were analyzed retrospectively. All the patients were divided into normal ovarian response group (4 ≤the number of retrieved oocytes ≤15) and high ovarian response group (the number of retrieved oocytes > 15 ) ; the embryos with normal cleavage speed were designed as effective indicators, the reference threshold value of serum progestogen during late follicular phase was confirmed by drawing ROC curve. Results: ROC curve showed that the reference threshold value of serum progestogen during late follicular phase in normal ovarian response group was 4. 95 nmol/L; while the reference threshold value of serum progestogen during late follicular phase in high o-varian response group was 5. 95 nmol/L Conclusion: The reference threshold values of serum progestogen during late follicular phase in normal ovarian response group and high ovarian response group were 4. 95nmol/L and 5. 95 nmol

  5. Follicular-patterned thyroid lesions

    Directory of Open Access Journals (Sweden)



    Full Text Available Aim: Our aim is to determine the minimal cytopathologic criteria needed to make differential diagnosis in follicular-patterned lesions of the thyroid gland.Materials and Methods: We reviewed 56 fine needle aspiration cytology specimens which were reported as “suspicious for follicular-patterned lesions of thyroid” between years 2001 and 2005 in our hospital and their histological slides. Parameters for cytopathologic assesment are cellularity, colloid formation, multilayered rosette formation, follicular cell rings, monolayered sheets, intact follicles, hyperplastic papillae, hyaline stromal fragments, intranuclear inclusions, nuclear grooves, angulated nuclei, nucleoli, cerebriform nuclei, nuclear size, macrophages, flame cells and Hurthle cells. Statistical analysis was performed using χ2 and Fisher's-exact tests and Kolmogorov-Simirnov test.Results: Four cytopathologic features–cerebriform nuclei, angulated nuclei, nuclear grooves and intranuclear inclusion- were constantly observed in the follicular variant of papillary carcinoma (p< 0.05. Diluted colloid, monolayered sheet, nuclear size, macrophage and nucleoli were frequently seen in nodular hyperplasia (p< 0.05. The nuclear size was the sole differential cytopathologic criteria between follicular adenoma and follicular carcinoma (p<0.05.Conclusion: Detailed cytopathologic examination was found to be important in differentiating follicular variant of papillary carcinoma from nodular hyperplasia. On the other hand, none of the cytopathologic findings were sufficient to distinguish follicular adenoma from follicular carcinoma. Therefore, cytopathologists should report such lesions as “follicular neoplasms”.

  6. Surge-damping vacuum valve (United States)

    Bullock, Jack C.; Kelly, Benjamin E.


    A valve having a mechanism for damping out flow surges in a vacuum system which utilizes a slotted spring-loaded disk positioned adjacent the valve's vacuum port. Under flow surge conditions, the differential pressure forces the disk into sealing engagement with the vacuum port, thereby restricting the flow path to the slots in the disk damping out the flow surge.

  7. Demand surge following earthquakes (United States)

    Olsen, Anna H.


    Demand surge is understood to be a socio-economic phenomenon where repair costs for the same damage are higher after large- versus small-scale natural disasters. It has reportedly increased monetary losses by 20 to 50%. In previous work, a model for the increased costs of reconstruction labor and materials was developed for hurricanes in the Southeast United States. The model showed that labor cost increases, rather than the material component, drove the total repair cost increases, and this finding could be extended to earthquakes. A study of past large-scale disasters suggested that there may be additional explanations for demand surge. Two such explanations specific to earthquakes are the exclusion of insurance coverage for earthquake damage and possible concurrent causation of damage from an earthquake followed by fire or tsunami. Additional research into these aspects might provide a better explanation for increased monetary losses after large- vs. small-scale earthquakes.


    Directory of Open Access Journals (Sweden)

    L. Safdarian


    Full Text Available There is a challenging debate on the effect of premature luteinization on the clinical outcome of ‘controlled ovarian hyperstimulation' (COH using long ‘gonadotropin-releasing hormone agonist' (GnRHa cycles. Premature luteinization is defined as late follicular progesterone/estradiol ratio more than 1 on the day of human chorionic gonadotropin (HCG administration. We carried out a retrospective case-control study on 75 conceived cases versus 75 not-conceived control women, receiving long GnRHa cycles in their first cycle of treatment. Premature luteinization developed in 15% of the case group vs. 22% of the control group. Neither the late follicular progesterone/estradiol (P/E2 ratio was significantly different between the two groups, nor the day 3 follicle stimulating hormone (FSH, serum estradiol level on the HCG day, total amount of human menopausal gonadotropins ampoules, number of follicles, retrieved oocytes and transferred embryos. Endometrial thickness was significantly more in the pregnant women than in the non-pregnant group. Premature luteinization seems not to adversely affect the clinical outcome of COH.


    Directory of Open Access Journals (Sweden)

    Giuseppe Rossi


    Full Text Available Follicular lymphoma(FL is the most common indolent non-Hodgkin lymphoma and constitutes 15% to 30% of lymphoma diagnoses. The natural history of the disease is characterized by recurrent relapses and progressively shorter remissions with a median survival of 10yrs. The impossibility of a chieving a definite cure, have prompted investigations into the possible role of more effective and less toxic strategies with innovative therapeutic agents.  Recently Casulo et al demonstrated that approximately 20% of patients with FL actually relapse within 2 years after achieving remission with R-CHOP and have a poor prognosis. It is conceivable that this particularly chemoresistant population would benefit from specifically targeting the biologic and genetic factors that likely contribute to their poor prognosis. Evolving strategies for difficult to treat FL patients have recently considered  immunomodulatory agents, new monoclonal antibodies as well as drugs targeting selective intracellular pathways. The importance of targeting the microenvironment together with the malignant FL cell has been particularly underscored. We review the most promising approaches, such as the combination of anti-CD20 antibodies with immunomodulatory drugs (Lenalidomide, with mAbs directed against other surface antigens such as CD22 and CD23 (epratuzumab, lumiliximab, with immunomodulatory antibodies such as PD-1, or with inhibitors of key steps in the B-cell receptor pathway signaling such as PI3K inibithors(idelalisib, duvelisib. Another highly attractive approach is the application of the bi-specific T-cell engaging (BiTE antibody blinatumomab which targets both CD19 and CD3 antigens. Moreover, we highlight the potential of these therapies,  taking into account their toxicity. Of course we must wait for Phase III trials results to confirm the benefit of these new treatment strategies toward a new era of chemotherapy-free treatment for follicular lymphoma.

  10. Hemosiderin laden macrophages and hemosiderin within follicular cells distinguish benign follicular lesions from follicular neoplasms

    Directory of Open Access Journals (Sweden)

    Jaffar Reema


    Full Text Available Background: Published criteria to distinguish benign colloid nodules from follicular neoplasms emphasize only three interdependent features: size of follicles, amount of colloid, and cellularity. There is a need for the validation of other independent criteria. Methods: This study quantified the significance of cystic change, defined as presence of macrophages, and the presence of hemosiderin in either the macrophages or follicular cells. The cohort consisted of 165 patients with fine needle aspiration (FNA and histologic follow-up of either goiter (101, follicular adenoma (47, or follicular carcinoma (17. Papillary thyroid carcinomas and Hürthle cell neoplasms were excluded from the cohort, because these categories are known to show cystic change and hemosiderin. FNAs were reviewed blindly with the most cellular slide scored for the presence of macrophages and/or hemosiderin. Results: Hemosiderin within macrophages were seen in 67% (68 of 101 of the goiters and only 6% (four of 64 of follicular neoplasms ( P < .0001. All four follicular neoplasms with hemosiderin in macrophages were adenomas. Three of these four had equivocal features of a benign colloid nodule histologically. None of the 17 follicular carcinomas had hemosiderin in macrophages ( P < .12. Macrophages without hemosiderin also strongly distinguished goiters from neoplasms (83% vs 17% but appears less useful as a criterion since macrophages were present within 3 of 17 follicular carcinomas. Hemosiderin within follicular epithelial cells was present in 18% (18 of 101 of goiters, whereas none of the 64 follicular neoplasms had intraepithelial hemosiderin ( P < .0003. Conclusions: If papillary thyroid carcinoma and Hürthle cell neoplasm are ruled out, our findings indicate that the presence of hemosiderin virtually excludes a clinically significant follicular neoplasm.

  11. Radiation therapy of follicular lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Koguchi, Masahiko; Nakamura, Naoki; Tsubokura, Takuji; Gomi, Koutarou; Yamashita, Takashi [Japanese Foundation for Cancer Research, Tokyo (Japan). Hospital; Shikama, Naoto


    The follicular lymphoma, exactly, the cancer of follicular center and germinal center B lymphocytes, is reviewed on its immunological, pathological and genetic diagnoses, epidemiology, clinical symptoms, prognosis factors, therapy and assessment of therapy effects together with respective therapy of follicular small cleaved and follicular mixed small cleaved and large cell lymphoma of grade I, II; and of follicular large cell lymphoma of grade III. The therapy is essentially the radiotherapy combined with chemotherapy and others, of which effect is mainly assessed by CT. In clinical application grade II, III, irradiation of X- and electron rays and their combination is done in a fractionated manner with the maximal dose of around 35 Gy. In clinical disease grade II, III, regimen of irradiation is not fixed. In III, IV, chemotherapy and immunotherapy are major. In recurrence and malignant transformation, there is a report of large dose chemotherapy + whole body irradiation + bone marrow transplantation. (K.H.)

  12. Storm surges formation in the White and Barents Seas (United States)

    Arkhipkin, Victor; Dobrolyubov, Sergey; Korablina, Anastasia; Myslenkov, Stanislav


    Investigation of storm surges in the Arctic seas are of high priority in Russia due to the active development of offshore oil and gas, construction of facilities in the coastal zone, as well as for the safety of navigation. It is important to study the variability of surges, to predict this phenomena and subsequent economic losses, thus including such information into the Russian Arctic Development Program 2020. Surges in the White and Barents Seas are caused mainly by deep cyclones of two types: "diving" from the north (88% of all cyclones) and western. The average height of the storm surges in the White Sea is 0.6-0.9 m. An average duration of storm surges is about 80 hours. Mathematical modeling is used to analyze the characteristics of storm surges formation in the Dvina Bay of the White Sea, and in the Varandey village on the Barents Sea coast. Calculating storm surge heights in the White and Barents seas is performed using the ADCIRC model on an unstructured grid with a step from 20 km in the Barents Sea to 100 m in the White Sea. Unstructured grids allowed keeping small features of the coastline of the White and Barents seas, small islands and shallow banks, and assessing their impact on the development and transformation of wind-generated waves. The ADCIRC model used data of wind field reanalysis CFSv2. The storm surges were simulated for the time period from 1979 to 2010 and included scenarios with / without direct atmospheric pressure forcing, waves and tides. Numerical experiments have revealed distribution of storm surges in channels of the Northern Dvina River delta. The storm surges spreads in the model from the north-north-west of the Dvina Bay. As storm surge moves from the wellhead to the seaside estuary of the Northern Dvina (district Solombala), its height increases from 0.5 to 2 m. We also found a non-linear interaction of the surge and tide during the phase of surge destruction. This phenomenon is the highest in the period of low water, and the

  13. Scenario-based Storm Surge Vulnerability Assessment of Catanduanes (United States)

    Suarez, J. K. B.


    After the devastating storm surge effect of Typhoon Haiyan, the public recognized an improved communication about risks, vulnerabilities and what is threatened by storm surge. This can be provided by vulnerability maps which allow better visual presentations and understanding of the risks and vulnerabilities. Local implementers can direct the resources needed for protection of these areas. Moreover, vulnerability and hazard maps are relevant in all phases of disaster management designed by the National Disaster Risk Reduction Council (NDRRMC) - disaster preparedness, prevention and mitigation and response and recovery and rehabilitation. This paper aims to analyze the vulnerability of Catanduanes, a coastal province in the Philippines, to storm surges in terms of four parameters: population, built environment, natural environment and agricultural production. The vulnerability study relies on the storm surge inundation maps based on the Department of Science and Technology Nationwide Operational Assessment of Hazards' (DOST-Project NOAH) proposed four Storm Surge Advisory (SSA) scenarios (1-2, 3, 4, and 5 meters) for predicting storm surge heights. To determine total percent affected for each parameter elements, an overlay analysis was performed in ArcGIS Desktop. Moreover, vulnerability and hazard maps are generated as a final output and a tool for visualizing the impacts of storm surge event at different surge heights. The result of this study would help the selected province to know their present condition and adapt strategies to strengthen areas where they are found to be most vulnerable in order to prepare better for the future.

  14. Storm surge variational assimilation model

    Directory of Open Access Journals (Sweden)

    Shi-li HUANG


    Full Text Available To eliminate errors caused by uncertainty of parameters and further improve capability of storm surge forecasting, the variational data assimilation method is applied to the storm surge model based on unstructured grid with high spatial resolution. The method can effectively improve the forecasting accuracy of storm surge induced by typhoon through controlling wind drag force coefficient parameter. The model is first theoretically validated with synthetic data. Then, the real storm surge process induced by the TC 0515 typhoon is forecasted by the variational data assimilation model, and results show the feasibility of practical application.


    Institute of Scientific and Technical Information of China (English)



    This paper describes the relationship between haman oocyte matarity for fcrtilization andpre-ovulalory follicular fluid hormone levels in induced ova]story cycle by trealmcm withclomiphenz+HMG or clomiphene+HMC+HCG. 32 hours after urine LH--surge or 34

  16. Earth Observation in aid of surge monitoring and forecasting: ESA's eSurge Project (United States)

    Harwood, Phillip; Cipollini, Paolo; Snaith, Helen; Høyer, Jacob; Dwyer, Ned; Dunne, Declan; Stoffelen, Ad; Donlon, Craig


    The understanding and realistic modelling of surges supports both preparation and mitigation activities and should eventually bring enormous societal benefits, especially to some of the world's poorest countries. Earth Observation data from satellites have an important role to play in storm surge monitoring and forecasting, but the full uptake of these data by the users (such as environmental agencies and tidal prediction centres) must be first encouraged by showcasing their usefulness, and then supported by providing easy access. The European Space Agency has recognized the above needs and, through its Data User Element (DUE) programme, has initiated in 2011 the eSurge project, whose aims are: a) to contribute through Earth Observation to an integrated approach to storm surge, wave, sea-level and flood forecasting as part of a wider optimal strategy for building an improved forecast and warning capability for coastal inundation; and b) to increase the use of the advanced capabilities of ESA and other satellite data for storm surge applications. The project is led by Logica UK, with NOC (UK), DMI (Denmark), CMRC (Ireland) and KNMI (Netherlands) as scientific partners. eSurge aims to provide easy access to a wide range of relevant data for a range of historical surge events, as well as performing a series of experiments to demonstrate the value of this data, and running workshops and training courses to help users make use of the available data. The eSurge database of Earth Observation and in situ measurements for past surge events is now publicly available. In 2013 the project moves into its service demonstration phase, adding more data and events, including a demonstration near real time service. The project works closely with its users in order to meet their needs and to maximise the return of this data. A novel dataset provided by eSurge is coastal altimetry. Coastal altimetry has a prominent role to play as it measures directly the total water level envelope

  17. The use of coastal altimetry to support storm surge studies in project eSurge (United States)

    Cipollini, P.; Harwood, P.; Snaith, H.; Vignudelli, S.; West, L.; Zecchetto, S.; Donlon, C.


    turn can be used to improve the forecast of wave setup and overtopping processes. We will present examples of how altimetry has captured a few significant surge events in European Seas, and we will describe how a multi-mission coastal altimetry processor is going to be integrated in the eSurge system. The delayed-time reprocessed coastal altimetry data will be blended with tide gauge data to extract the main modes of variability in the coastal regions. Then data from the tide gauges can be used to estimate water level in real time, based on the modes of variability found. In a later phase of the project, the eSurge coastal altimetry processor will be extended to be able to ingest Near-Real-time (NRT) raw altimetric waveforms and generate the relevant NRT products, a definite first for coastal altimetry. The pilot regions for this application will be the European Seas (where an area of specific interest is the Northern Adriatic, which is being investigated within a related initiative called eSurge-Venice) and the North Indian Ocean. In summary, we expect eSurge to be one of the first pre-operational applications of coastal altimetry and a proof of the benefits to society that can be brought by this relatively new branch of marine remote sensing.

  18. Measurement of the filling height of transient two-phase surge flows in pipelines by means of electronics; Messung der Fuellhoehe von transienten Zweiphasenschwallstroemungen in Rohrleitungen mittels Ultraschall

    Energy Technology Data Exchange (ETDEWEB)

    Hofmann, B.; Rockstroh, M. [Technische Univ. Dresden (Germany). Inst. fuer Energiemaschinen und Maschinenlabor


    The aim of the ultrasonic measurements was the determination of the time course of the level of a transient surge flow with swirl and waves in partly filled roughly horizontally laid pipelines. The running time of the ultrasonic waves from the test head to the liquid surface and back was measured for this purpose. The course of the stress was recorded digitally and was evaluated with the aid of software. Waves, swirl, turbulence of flow and introduced test bodies in the flow caused typical echoes, which had to be taken into account in the evaluation. As the test head was fitted on the outside of the pipe (clamp-on technique), the pipe wall thickness and the speed of sound in the pipe wall had to be included in the calculation of filling height by means of a correction. [Deutsch] Ziel der Ultraschallmessungen war die Bestimmung des zeitlichen Verlaufes der Fuellhoehe einer transienten, drall- und wellenbehafteten Schwallstroemung in teilgefuellten, etwa horizontal verlegten Rohrleitungen. Hierzu wurde die Laufzeit der Ultraschallwellen vom Pruefkopf zur Fluessigkeitsoberflaeche und zurueck gemessen. Die Laufzeit der Ultraschallwellen wurde auf eine quasi-analog elektrische Spannung abgebildet. Der Spannungsverlauf wurde digital aufgezeichnet und softwaregestuetzt ausgewertet. Wellen, Drall, Stroemungsturbulenzen sowie eingebrachte Pruefkoerper in der Stroemung hatten typische Echoerscheinungen zur Folge, die bei der Auswertung zu beruecksichtigen waren. Da der Pruefkopf aussen am Rohr angebracht war (clamp-on-Technik), musste die Rohrwandstaerke und die Schallgeschwindigkeit in der Rohrwandung mittels eines Korrekturgliedes in die Fuellhoehenberechnung eingezogen werden. (orig.)

  19. Surge dynamics on Bering Glacier, Alaska, in 2008–2011

    Directory of Open Access Journals (Sweden)

    M. Braun


    Full Text Available A surge cycle of the Bering Glacier system, Alaska, is examined using observations of surface velocity obtained using synthetic aperture radar (SAR offset tracking, and elevation data obtained from the University of Alaska Fairbanks LiDAR altimetry program. After 13 yr of quiescence, the Bering Glacier system began to surge in May 2008 and had two stages of accelerated flow. During the first stage, flow accelerated progressively for at least 10 months and reached peak observed velocities of ~ 7 m d−1. The second stage likely began in 2010. By 2011 velocities exceeded 9 m d−1 or ~ 18 times quiescent velocities. Fast flow continued into July 2011. Surface morphology indicated slowing by fall 2011; however, it is not entirely clear if the surge is yet over. The quiescent phase was characterized by small-scale acceleration events that increased driving stresses up to 70%. When the surge initiated, synchronous acceleration occurred throughout much of the glacier length. Results suggest that downstream propagation of the surge is closely linked to the evolution of the driving stress during the surge, because driving stress appears to be tied to the amount of resistive stress provided by the bed. In contrast, upstream acceleration and upstream surge propagation is not dependent on driving stress evolution.

  20. Nonlinear chaotic model for predicting storm surges

    Directory of Open Access Journals (Sweden)

    M. Siek


    Full Text Available This paper addresses the use of the methods of nonlinear dynamics and chaos theory for building a predictive chaotic model from time series. The chaotic model predictions are made by the adaptive local models based on the dynamical neighbors found in the reconstructed phase space of the observables. We implemented the univariate and multivariate chaotic models with direct and multi-steps prediction techniques and optimized these models using an exhaustive search method. The built models were tested for predicting storm surge dynamics for different stormy conditions in the North Sea, and are compared to neural network models. The results show that the chaotic models can generally provide reliable and accurate short-term storm surge predictions.

  1. Gonadotropin-releasing hormone, estradiol, and inhibin regulation of follicle-stimulating hormone and luteinizing hormone surges: implications for follicle emergence and selection in heifers. (United States)

    Haughian, James M; Ginther, O J; Diaz, Francisco J; Wiltbank, Milo C


    Mechanisms regulating gonadotropin surges and gonadotropin requirements for follicle emergence and selection were studied in heifers. Experiment 1 evaluated whether follicular inhibins regulate the preovulatory luteinizing hormone (LH)/follicle-stimulating hormone (FSH) surges elicited by gonadotropin-releasing hormone (GnRH) injection (Hour = 0) and the subsequent periovulatory FSH surge. Treatments included control (n = 6), steroid-depleted bovine follicular fluid (bFF) at Hour -4 (n = 6), and bFF at Hour 6 (n = 6). Gonadotropins in blood were assessed hourly from Hours -6 to 36, and follicle growth tracked by ultrasound. Consistent with inhibin independence, bFF at Hour -4 did not impact the GnRH-induced preovulatory FSH surge, whereas treatment at Hour 6 delayed onset of the periovulatory FSH surge and impeded growth of a new follicular wave. Experiment 2 examined GnRH and estradiol (E2) regulation of the periovulatory FSH surge. Treatment groups were control (n = 8), GnRH-receptor antagonist (GnRHr-ant, n = 8), and E2 + GnRHr-ant (n = 4). GnRHr-ant (acyline) did not reduce the concentrations of FSH during the periovulatory surge and early follicle development (8.0 mm) was prevented by GnRHr-ant. Addition of E2 delayed both the onset of the periovulatory FSH surge and emergence of a follicular wave. Failure to select a dominant follicle in the GnRHr-ant group was associated with reduced concentrations of LH but not FSH. Maximum diameter of F1 in controls (13.3 ± 0.5 mm) was greater than in both GnRHr-ant (7.7 ± 0.3 mm) and E2 + GnRHr-ant (6.7 ± 0.8 mm) groups. Results indicated that the periovulatory FSH surge stems from removal of negative stimuli (follicular E2 and inhibin), but is independent of GnRH stimulation. Emergence and early growth of follicles (until about 8 mm) requires the periovulatory FSH surge but not LH pulses. However, follicular deviation and late-stage growth of a single dominant follicle requires GnRH-dependent LH pulses.

  2. DAPI检测卵泡期绵羊生殖器官中细胞凋亡的比较研究%Study on apoptosis in sheep generative organ at follicular phase by DAPI

    Institute of Scientific and Technical Information of China (English)

    葛晨霞; 王龙涛; 李向军; 王欣睿; 姜怀志


    为探讨在卵泡期绵羊生殖器官中细胞凋亡的作用机制,本试验以小尾寒羊和萨福克羊为研究对象,采用DAPI(4',6'联脒-2-苯基吲哚)原住荧光标记技术,对高繁殖力品种小尾寒羊和低繁殖力品种萨福克羊成年母羊卵泡期主要生殖器官(卵巢、输卵管、子宫)进行细胞凋亡的确认与定位.结果显示:小尾寒羊和萨福克羊卵巢中卵泡上皮细胞、颗粒细胞、膜细胞均有凋亡现象.在三级卵泡和成熟卵泡的颗粒细胞和膜细胞中,萨福克羊比小尾寒羊表达出较多数量的凋亡细胞,两品种羊在卵泡期输卵管各部,子宫内膜腺体中几乎均未检测到凋亡细胞,子宫内膜基质中检测到少量细胞发生凋亡.因此,研究表明细胞凋亡是母羊生殖器官变化的重要调节机制,可能与造成两者繁殖力高低差异有关.%To study the regulatory mechanism on apoptosis in sheep generative organ at follicular phase, in situ fluorescent labeling (4',6'-diamidino-2-phenylindole, DAPI) was used to confirm and locate apoptosis cells in major reproductive organs (ovaries,oviduct and uterus) of Small-tails Han Sheep (SHS) and Suffolk Sheep (SS) ,which have high and low productivity respectively. The finding of in situ fluorescent labeling (DAPI) indicate that, apoptosis might take place in follicular epithelium cells (FeC),granule cells (GrC) and theca cells (ThC) of SHS and SS. Suffolk Sheep had more apoptosis of GrC and ThC in tertiary follicle and graafian follicle (VG) than SHS. Neither SHS nor SS apoptotic cells were detected in oviduct and glandular organ during follicular phase (FP). While a few endometrial stroma cells (StC) with apoptosis were detected. The result showed that apoptosis is an important regulatory mechanism in reproductive organs of ewe,and it might result in difference in production between SHS and SS.

  3. Surge dynamics on Bering Glacier, Alaska, in 2008–2011

    Directory of Open Access Journals (Sweden)

    M. Braun


    Full Text Available A 2008–2011 surge of Bering Glacier, Alaska is examined using observations of surface velocity and surface elevation change. Velocity measurements are obtained using synthetic aperture radar (SAR offset tracking and elevation data are obtained from the University of Alaska Fairbanks LiDAR altimetry program. Bering Glacier began to surge in May 2008 and had two phases of accelerated flow. The first phase accelerated progressively for at least 10 months and reached peak observed velocities of ~7 m d−1. Results suggest that during the quiescent phase, prior to the surge, periods of accelerated flow increased driving stresses up to 70% in a ~10 km-long section of the Lower Bering. When the first phase of the surge initiated, synchronous acceleration occurred throughout much of the glacier length, indicating widespread pressurization of the bed, but the largest accelerations initiated at the location where driving stress built up during quiescence. From there, rapid flow velocities propagated upstream and downstream across much of the glacier length and transpired as small, transient and unorganized propagation fronts. The second phase occurred in 2011 and was of comparable scale to the surge in 1993–1995, with velocities exceeding 9 m d−1 or ~18 times quiescent velocities.

  4. 7 CFR 58.218 - Surge tanks. (United States)


    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Surge tanks. 58.218 Section 58.218 Agriculture....218 Surge tanks. If surge tanks are used for hot milk, and temperatures of product including foam being held in the surge tank during processing, is not maintained at a minimum of 150 °F, then two...

  5. Brief Communication: Twelve-year cyclic surging episode at Donjek Glacier in Yukon, Canada

    Directory of Open Access Journals (Sweden)

    T. Abe


    Full Text Available Surge-type glaciers repeat their short active phase and much longer quiescent phase usually every several decades or longer, but detailed observations of the evolution cycles have been limited to a few glaciers. Here we report three surging episodes in 1989, 2001, and 2013 at Donjek Glacier in the Yukon, indicating remarkably regular and short repeat cycles of 12 years. The surging area is limited within the ~ 20 km section from the terminus, where the flow width significantly narrows than upstream, suggesting a strong control of the valley constriction on the surge dynamics.

  6. Brief Communication: Twelve-year cyclic surging episodes at Donjek Glacier in Yukon, Canada (United States)

    Abe, Takahiro; Furuya, Masato; Sakakibara, Daiki


    Surge-type glaciers repeat their short active phase and their much longer quiescent phase usually every several decades or longer, but detailed observations of the evolution cycles have been limited to only a few glaciers. Here we report three surging episodes in 1989, 2001, and 2013 at Donjek Glacier in the Yukon, Canada, indicating remarkably regular and short repeat cycles of 12 years. The surging area is limited within the ˜ 20 km section from the terminus, originating in an area where the flow width significantly narrows downstream, suggesting a strong control of the valley constriction on the surge dynamics.

  7. Brief Communication: Twelve-year cyclic surging episode at Donjek Glacier in Yukon, Canada (United States)

    Abe, T.; Furuya, M.; Sakakibara, D.


    Surge-type glaciers repeat their short active phase and much longer quiescent phase usually every several decades or longer, but detailed observations of the evolution cycles have been limited to a few glaciers. Here we report three surging episodes in 1989, 2001, and 2013 at Donjek Glacier in the Yukon, indicating remarkably regular and short repeat cycles of 12 years. The surging area is limited within the ~ 20 km section from the terminus, where the flow width significantly narrows than upstream, suggesting a strong control of the valley constriction on the surge dynamics.

  8. Angiolymphoid hyperplasia with follicular mucinosis

    Directory of Open Access Journals (Sweden)

    Joshi Rajiv


    Full Text Available Follicular mucinosis occurring along with angiolymphoid hyperplasia with eosinophils (ALHE has been described in a 54-year-old female. The patient presented with pruritic erythematous papules on the left frontoparietal scalp. Histopathological examination showed prominent blood vessels in the dermis lined by plump histiocytoid endothelial cells that were surrounded by a dense lymphoid infiltrate with numerous eosinophils; these findings are typical of angiolymphoid hyperplasia with eosinophils. Features of follicular mucinosis were observed in the same section with several hyperplastic follicular infundibula containing pools of mucin in the infundibular epithelium. The concurrent occurrence of these two distinct histopathological patterns in the same biopsy specimen has been described in only three cases to date.

  9. Follicular infundibulum tumour presenting as cutaneous horn

    Directory of Open Access Journals (Sweden)

    Jayaraman M


    Full Text Available Tumour of follicular infundibulum is an organoid tumour with a plate like growth attached to the epidermis with connection from the follicular epithelium. We are reporting such a case unusually presenting as cutaneous horn.

  10. Follicular Lymphoma Presenting with Leptomeningeal Disease


    Rubens Costa; Ricardo Costa; Renata Costa


    Follicular lymphoma is generally an indolent B cell lymphoproliferative disorder of transformed follicular center B cells. Central nervous system metastasis is a very rare complication portending a very poor prognosis. We report a rare case of follicular lymphoma presenting with leptomeningeal involvement achieving a complete remission after initial therapy.

  11. Follicular Lymphoma Presenting with Leptomeningeal Disease

    Directory of Open Access Journals (Sweden)

    Rubens Costa


    Full Text Available Follicular lymphoma is generally an indolent B cell lymphoproliferative disorder of transformed follicular center B cells. Central nervous system metastasis is a very rare complication portending a very poor prognosis. We report a rare case of follicular lymphoma presenting with leptomeningeal involvement achieving a complete remission after initial therapy.

  12. The surge-like eruption of a miniature filament

    Institute of Scientific and Technical Information of China (English)

    Jia-Yan Yang; Yun-Chun Jiang; Dan yang; Yi Bi; Bo Yang; Rui-Sheng Zheng; Jun-Chao Hong


    We report on the rare eruption of a miniature Hα filament that took the form of a surge.The filament first underwent a full development within 46 min and then began to erupt 9 min later,followed by a compact,impulsive X-ray class M2.2 flare with a two-ribbon nature only at the early eruption phase.During the eruption,its top rose,whereas the two legs remained rooted in the chromosphere and showed little swelling perpendicular to the rising direction.This led to a surge-like eruption with a narrow angular extent.Similar to the recent observations for standard and blowout X-ray jets by Moore et al.,we thus define it as a "blowout Hα surge." Furthermore,our observations showed that the eruption was associated with (1) a coronal mass ejection guided by a pre-existing streamer,(2) abrupt,significant,and persistent changes in the photospheric magnetic field around the filament,and (3) a sudden disappearance of a small pore.These observations thus provide evidence that a blowout surge is a small-scale version of a large-scale filament eruption in many aspects.Our observations further suggest that at least part of the Hα surges belong to blowout-type cases,and the exact distinction between the standard and blowout Hα surges is important in understanding their different origins and associated eruptive phenomena.

  13. A surge of Perseibreen, Svalbard, examined using aerial photography and ASTER high resolution satellite imagery


    Dowdeswell, Julian A.; Benham, Toby J.


    The identification of surge activity is important in assessing the duration of the active and quiescent phases of the surge cycle of Svalbard glaciers. Satellite and aerial photographic images are used to identify and describe the form and flow of Perseibreen, a valley glacier of 59 km2 on the east coast of Spitsbergen. Heavy surface crevassing and a steep ice front, indicative of surge activity, were first observed on Perseibreen in April 2002. Examination of high resolution (15 m) Advanced ...

  14. Glacier surge after ice shelf collapse. (United States)

    De Angelis, Hernán; Skvarca, Pedro


    The possibility that the West Antarctic Ice Sheet will collapse as a consequence of ice shelf disintegration has been debated for many years. This matter is of concern because such an event would imply a sudden increase in sea level. Evidence is presented here showing drastic dynamic perturbations on former tributary glaciers that fed sections of the Larsen Ice Shelf on the Antarctic Peninsula before its collapse in 1995. Satellite images and airborne surveys allowed unambiguous identification of active surging phases of Boydell, Sjögren, Edgeworth, Bombardier, and Drygalski glaciers. This discovery calls for a reconsideration of former hypotheses about the stabilizing role of ice shelves.

  15. Performance Comparison of the European Storm Surge Models and Chaotic Model in Forecasting Extreme Storm Surges (United States)

    Siek, M. B.; Solomatine, D. P.


    Storm surge modeling has rapidly developed considerably over the past 30 years. A number of significant advances on operational storm surge models have been implemented and tested, consisting of: refining computational grids, calibrating the model, using a better numerical scheme (i.e. more realistic model physics for air-sea interaction), implementing data assimilation and ensemble model forecasts. This paper addresses the performance comparison between the existing European storm surge models and the recently developed methods of nonlinear dynamics and chaos theory in forecasting storm surge dynamics. The chaotic model is built using adaptive local models based on the dynamical neighbours in the reconstructed phase space of observed time series data. The comparison focused on the model accuracy in forecasting a recently extreme storm surge in the North Sea on November 9th, 2007 that hit the coastlines of several European countries. The combination of a high tide, north-westerly winds exceeding 50 mph and low pressure produced an exceptional storm tide. The tidal level was exceeded 3 meters above normal sea levels. Flood warnings were issued for the east coast of Britain and the entire Dutch coast. The Maeslant barrier's two arc-shaped steel doors in the Europe's biggest port of Rotterdam was closed for the first time since its construction in 1997 due to this storm surge. In comparison to the chaotic model performance, the forecast data from several European physically-based storm surge models were provided from: BSH Germany, DMI Denmark, DNMI Norway, KNMI Netherlands and MUMM Belgium. The performance comparison was made over testing datasets for two periods/conditions: non-stormy period (1-Sep-2007 till 14-Oct-2007) and stormy period (15-Oct-2007 till 20-Nov-2007). A scalar chaotic model with optimized parameters was developed by utilizing an hourly training dataset of observations (11-Sep-2005 till 31-Aug-2007). The comparison results indicated the chaotic

  16. Dune erosion during storm surges

    NARCIS (Netherlands)

    Van Thiel de Vries, J.S.M.


    Large parts of The Netherlands are protected from flooding by a narrow strip of sandy beaches and dunes. The aim of this thesis is to extend the existing knowledge of dune erosion during storm surges as it occurs along the Dutch coast. The thesis discusses: • A large scale dune erosion experiment to

  17. Response of thyroid follicular cells to gamma irradiation compared to proton irradiation. I. Initial characterization of DNA damage, micronucleus formation, apoptosis, cell survival, and cell cycle phase redistribution (United States)

    Green, L. M.; Murray, D. K.; Bant, A. M.; Kazarians, G.; Moyers, M. F.; Nelson, G. A.; Tran, D. T.


    .12 Gy(-1) for protons), which suggests that the higher level of survival of gamma-irradiated cells could be attributed to the persistence of nonlethally irradiated thyrocytes and/or the capacity to repair damage more effectively than cells exposed to equal physical doses of protons. The final assessment in this study was radiation-induced cell cycle phase redistribution. Gamma rays and protons produced a similar dose-dependent redistribution toward a predominantly G(2)-phase population. From our cumulative results, it seems likely that a majority of the proton-irradiated cells would not continue to divide. In conclusion, these findings suggest that there are quantitative and qualitative differences in the biological effects of proton beams and gamma rays. These differences could be due to structured energy deposition from the tracks of primary protons and the associated high-LET secondary particles produced in the targets. The results suggest that a simple dose-equivalent approach to dosimetry may be inadequate to compare the biological responses of cells to photons and protons.

  18. Progress in Study on Shen-invigorating Herbs Used in Promoting Follicular Development

    Institute of Scientific and Technical Information of China (English)

    连方; 王玉东; 张宁


    @@ The practice of stimulating follicular development by Shen-invigorating herbs is directed by traditional Chinese medical theories of "the Shen stores essence of life and governs reproduction" and also the theory of "females' periodicity of the ebb and flow of the blood sea". The follicular phase has physiologic characteristics of blood sea ebbing and yin growing, accordingly using the treating principle of invigorating Shen and nourishing the essence can stimulate follicles' normal development and maturation which can cure many diseases such as female infertility, menoxenia and amenorrhoea. This article will give an introduction of the recent 10 years' research of Shen-invigorating treatment in stimulating follicular development .

  19. Ovarian Follicular Dynamics, Ovarian Follicular Growth, Oocyte Yield, Embryo Production and Repeated Oocyte Pick Up in Thai Native Heifers Undergoing Superstimulation

    Directory of Open Access Journals (Sweden)

    J. Chasombat


    Full Text Available The objective of this study was to compare the effectiveness of the protocols for superstimulation of follicular growth in Thai native heifers. Heifers (n = 20 were randomly divided into four groups of five heifers/group. Heifers were given a single dose by i.m. administration of 100 mg Follicle Stimulating Hormone dissolved in polyvinylpyrrolidone (FSHp at 24 h. Ovum pick up (OPU occurred at 72 h (F24O72 protocol; Group 1 or 96 h (F24O96 protocol; Group 2, and at 36 h and OPU at 72 h (F36O72 protocol; Group 3 or 96 h (F36O96 protocol; Group 4 after follicular ablation. The dynamics of ovarian follicular growth were monitored by twice-daily ultrasonographic examinations. Blood sample collections were performed every 12 h after initiation of treatment for assessment of FSH, E2 and P4 profiles. All heifers were subjected to eight repeated sequential sessions of OPU. The follicular deviation commenced 24±5.32 h after follicular ablation in all groups. The circulatory FSH surged quickly from 24 to 36 h (>0.8 ng/ml after follicular ablation and circulatory estrogen levels steadily increased from 36 h until OPU in all groups. At the end of the OPU sessions, the mean number of aspirated follicles/heifer/session in F36O72 protocol (Group 3 and F36O96 protocol (Group 4 were higher than in the two other groups (p<0.05. The number of cumulus-oocyte complexes (COCs, cleaved and day 8 blastocysts rates in the F36O72 protocol (Group 3 were higher than in the other groups (p<0.05. It can be concluded that a single dose i.m. administration of 100 mg FSHp at 36 h and OPU at 72 h after follicular ablation (F36O72 protocol; Group 3 was the most effective protocol for superstimulation of follicular growth for repeated OPU and subsequent in vitro embryo production in Thai native heifers.

  20. Rituximab maintenance improves clinical outcome of relapsed/resistant follicular non-Hodgkin lymphoma in patients both with and without rituximab during induction: results of a prospective randomized phase 3 intergroup trial

    NARCIS (Netherlands)

    M.H.J. van Oers; R. Klasa; R.E. Marcus; M. Wolf; E. Kimby; R.D. Gascoyne; A. Jack; M. van't Veer; A. Vranovsky; H. Holte; M. van Glabbeke; I. Teodorovic; C. Rozewicz; A. Hagenbeek


    We evaluated the role of rituximab (R) both in remission induction and maintenance treatment of relapsed/resistant follicular lymphoma (FL). A total of 465 patients were randomized to induction with 6 cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) (every 3 weeks) or R-CH

  1. Comments on metal oxide surge arresters surges energy absorption capacity

    Energy Technology Data Exchange (ETDEWEB)

    Martinez, M.L.B. [Escola Federal de Engenharia de Itajuba, Minas Gerais (Brazil); Zanetta, L.C. Jr. [E. Politecnica Univ. de Sao Paulo, Sao Paulo (Brazil)


    This paper presents an approach to determine the energy absorption capacity of metal oxide surge arrester resistors. The proposed approach deals with the discharge current peak versus discharge current time relation. A testing method and a statistical evaluation are proposed. After determining the discharge current withstanding limit of the tested metal oxide resistors, the prospective energy absorption capacity limit is computed. Finally, comments on the obtained results are presented.

  2. Observations of cyclone-induced storm surge in coastal Bangladesh

    CERN Document Server

    Chiu, Soyee


    Water level measurements from 15 tide gauges in the coastal zone of Bangladesh are analyzed in conjunction with cyclone tracks and wind speed data for 54 cyclones between 1977 and 2010. Storm surge magnitude is inferred from residual water levels computed by subtracting modeled astronomical tides from observed water levels at each station. Observed residual water levels are generally smaller than reported storm surge levels for cyclones where both are available, and many cyclones produce no obvious residual at all. Both maximum and minimum residual water levels are higher for west-landing cyclones producing onshore winds and generally diminish for cyclones making landfall on the Bangladesh coast or eastward producing offshore winds. Water levels observed during cyclones are generally more strongly influenced by tidal phase and amplitude than by storm surge alone. In only 7 of the 15 stations does the highest plausible observed water level coincide with a cyclone. While cyclone-coincident residual water level ...

  3. Dynamics of surge-type glaciers in West Kunlun Shan, Northwestern Tibet (United States)

    Yasuda, Takatoshi; Furuya, Masato


    Here we examine 31 glaciers in the West Kunlun Shan of the northwestern Tibetan Plateau and identify 9 as surge type. The method is based on satellite synthetic aperture radar and Landsat optical images, the former going back to 1992, the latter to 1972. To identify surge-type glaciers, we consider temporal changes in velocity, changes in glacier terminus position, propagation of a surge bulge, presence of looped and/or contoured medial moraines, and extensive crevassing. Other than the nine surge-type glaciers, we identify two that have likely surged, and six that may be surge type. But no glacier surges more than once during the observation period, meaning that the recurrence interval exceeds 42 years. In addition, we examine the evolution of the surface velocities at two surging glaciers with the unprecedented temporal resolution of down to 11 days over ˜7 years. The results show clear seasonal modulations by as much as ˜200% in early winter against those in early summer. This seasonal modulation in surface velocity suggests the presence of surface meltwater that reroutes through the englacial and subglacial drainage systems. Thus, our findings suggest that the hydrological processes originating in the surface meltwater play an important role in maintaining the yearlong active surging phase.

  4. Entourage: the immune microenvironment following follicular lymphoma



    In follicular lymphoma, nonmalignant immune cells are important. Follicular lymphoma depends on CD4+ cells, but CD8+ cells counteract it. We hypothesized that the presence of follicular lymphoma is associated with higher CD4+ than CD8+ cell numbers in the tumor microenvironment but not in the immune system. Using flow cytometry, pre-treatment and follow-up CD4/CD8 ratios were estimated in the bone marrow, blood and lymph nodes of untreated follicular lymphoma patients in two independent data ...

  5. Molecular signatures of thyroid follicular neoplasia

    DEFF Research Database (Denmark)

    Borup, R.; Rossing, M.; Henao, Ricardo


    The molecular pathways leading to thyroid follicular neoplasia are incompletely understood, and the diagnosis of follicular tumors is a clinical challenge. To provide leads to the pathogenesis and diagnosis of the tumors, we examined the global transcriptome signatures of follicular thyroid...... a mechanism for cancer progression, which is why we exploited the results in order to generate a molecular classifier that could identify 95% of all carcinomas. Validation employing public domain and cross-platform data demonstrated that the signature was robust and could diagnose follicular nodules...... and robust genetic signature for the diagnosis of FA and FC. Endocrine-Related Cancer (2010) 17 691-708...

  6. Lake Borgne Surge Barrier Study (United States)


    Savant , and Darla C. McVan September 2010 Approved for public release; distribution is unlimited. ERDC/CHL TR-10-10 September 2010 Lake...Borgne Surge Barrier Study S. Keith Martin, Gaurav Savant , and Darla C. McVan Coastal and Hydraulics Laboratory U.S. Army Engineer Research and...conducted by Keith Martin, Dr. Gaurav Savant , and Darla C. McVan. This work was conducted at the Coastal and Hydraulics Laboratory (CHL) of the

  7. The worst moment of superposed surge wave in upstream series double surge tanks of hydropower station (United States)

    Teng, Y.; Yang, J. D.; Guo, W. C.; Chen, J. P.


    It is a consensus to consider the superposed working conditions when calculating the surge wave in surge tank of hydropower station with long diversion tunnel. For the hydropower station with single surge tank, the method of determining the worst superposed moment is mature. However, for the hydropower station with upstream series double surge tanks, research in this field is still blank. Based on an engineering project, this paper investigated the worst moments and the control superposed working conditions about the maximum surge level and the minimum surge level of upstream series double surge tanks using numerical simulation. In addition, the incidence relations between the worst moment of superposed surge wave and the different areal array and distance between the two surge tanks are also carried out. The results showed that: With the decrease of the distance between auxiliary surge tank and upstream reservoir, the maximum values of the highest surge levels in the two surge tanks always reach close to but a little earlier than the bigger one time when the inflowing discharges of the two surge tanks reach the maximum. It is similar to the minimum values of lowest surge levels in the two surge tanks which also reach close to but a little later than the bigger one time when the outflowing discharges of the two surges reach the maximum. Moreover, the closer the area of auxiliary surge tank to the area of main surge tank is, the closer the worst moment to the bigger one time when inflow or outflow of the two surges reach the maximum will become.

  8. Time-frequency analysis of the Surge Onset in the Centrifugal Blower

    Directory of Open Access Journals (Sweden)

    Liskiewicz Grzegorz


    Full Text Available Time frequency analysis of the surge onset was performed in the centrifugal blower. A pressure signal was registered at the blower inlet, outlet and three locations at the impeller shroud. The time-frequency scalograms were obtained by means of the Continuous Wavelet Transform (CWT. The blower was found to successively operate in four different conditions: stable working condition, inlet recirculation, transient phase and deep surge. Scalograms revealed different spectral structures of aforementioned phases and suggest possible ways of detecting the surge predecessors.

  9. Menstrual cycle phase effects in the gender dimorphic stress cue reactivity of smokers. (United States)

    Saladin, Michael E; Wray, Jennifer M; Carpenter, Matthew J; McClure, Erin A; LaRowe, Steven D; Upadhyaya, Himanshu P; Gray, Kevin M


    We previously reported that female smokers evidence greater subjective craving and stress/emotional reactivity to personalized stress cues than males. The present study employed the same dataset to assess whether females in the follicular versus luteal phase of the menstrual cycle accounted for the gender differences. Two objective criteria, onset of menses and luteinizing hormone surge (evaluated via home testing kits), were used to determine whether female smokers were in either the follicular (n = 22) or the luteal (n = 15) phase of their menstrual cycle, respectively. The females and a sample of male smokers (n = 53) were then administered a laboratory-based cue reactivity paradigm that involved assessment of craving, stress, and emotional reactivity in response to counterbalanced presentations of both a personalized stress script and neutral/relaxed script. While there were no significant differences between females in the follicular versus luteal phase on any outcome measure, females in the luteal menstrual phase reported greater craving than males whereas females in the follicular phase reported greater stress and arousal than males and perceived the stress cues as more emotionally aversive than males. This preliminary investigation suggests that gender differences in craving versus affective responding to stress cues may, in part, be explained variation by menstrual cycle phase. Study limitations and implications of the findings for future research and treatment are briefly discussed. © The Author 2014. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail:

  10. Rituximab With or Without Yttrium Y-90 Ibritumomab Tiuxetan in Treating Patients With Untreated Follicular Lymphoma (United States)


    Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage II Grade 1 Contiguous Follicular Lymphoma; Stage II Grade 1 Non-Contiguous Follicular Lymphoma; Stage II Grade 2 Contiguous Follicular Lymphoma; Stage II Grade 2 Non-Contiguous Follicular Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma

  11. Pituitary down-regulation and follicular synchronization%降调节与卵泡发育同步化

    Institute of Scientific and Technical Information of China (English)



    The key aim of pituitary down-regulation in controlled ovarian stimulation (COS) is to prevent premature endogenous luteinizing hormone (LH) surge. The down-regulation protocols include long and short GnRH agonist protocols, as well as GnRH antagonist protocol. The long GnRH agonist protocol starting in the midluteal phase of the preceding cycle give the best IVF results with regard to oocyte yield and pregnancy rates. This long protocol induces profound suppression of endogenous release of gonadotrophins during the early follicular phase, allowing the antral follicles to grow coordinately in response to exogenous gonadotrophins to accomplish simultaneous maturation. The short and GnRH antagonist protocols can abridge the duration and complexity of COS and improve patient compliance as compared with the reference long protocol for IVF. Nevertheless, the explanation for the poor IVF-ET outcome achieved with these two protocols compared with long protocol could be, at least in part, related to pre-existing asychronization of early antral follicles before the start of gonadotrophin administration. The steroid (oral contraceptive pill (OCP), synthetic progestogen and natural estrogen) pre-treatment and GnRH-antagonist pre-treatment may be useful to suppress luteal FSH and reduce size differences among FSH-sensitive follicles during the early follicular phase. These approaches represent potential alternatives to synchronize multi-follicular development and improve ovarian stimulation results. However, larger studies are needed to confirm whether follicular growth coordination induced by steroids and premenstrual GnRH antagonist pre-treatment improve IVF-ET pregnancy rates with GnRH antagonist or short agonist protocols.%控制性卵巢刺激(COS)中垂体降调节的主要作用是预防早发内源性黄体生成素(LH)峰.降调节方案包括有促性腺激素释放激素激动剂(GnRH-a)长、短方案,以及GnRH拮抗剂(GnRH-ant)方案等.于前一周期黄体中

  12. Observing storm surges from satellite altimetry (United States)

    Han, Guoqi


    Storm surges can cause catastrophic damage to properties and loss of life in coastal communities. Thus it is important to enhance our capabilities of observing and forecasting storm surges for mitigating damage and loss. In this presentation we show examples of observing storm surges around the world using nadir satellite altimetry, during Hurricane Sandy, Igor, and Isaac, as well as other cyclone events. The satellite observations are evaluated against tide-gauge observations and discussed for dynamic mechanisms. We also show the potential of a new wide-swath altimetry mission, the Surface Water and Ocean Topography (SWOT), for observing storm surges.

  13. Debris entrainment and landform genesis during tidewater glacier surges (United States)

    Lovell, Harold; Fleming, Edward J.; Benn, Douglas I.; Hubbard, Bryn; Lukas, Sven; Rea, Brice R.; Noormets, Riko; Flink, Anne E.


    The englacial entrainment of basal debris during surges presents an opportunity to investigate processes acting at the glacier bed. The subsequent melt-out of debris-rich englacial structures during the quiescent phase produces geometrical ridge networks on glacier forelands that are diagnostic of surge activity. We investigate the link between debris entrainment and proglacial geomorphology by analyzing basal ice, englacial structures, and ridge networks exposed at the margins of Tunabreen, a tidewater surge-type glacier in Svalbard. The basal ice facies display clear evidence for brittle and ductile tectonic deformation, resulting in overall thickening of the basal ice sequence. The formation of debris-poor dispersed facies ice is the result of strain-induced metamorphism of meteoric ice near the bed. Debris-rich englacial structures display a variety of characteristics and morphologies and are interpreted to represent the incorporation and elevation of subglacial till via the squeezing of till into basal crevasses and hydrofracture exploitation of thrust faults, reoriented crevasse squeezes, and preexisting fractures. These structures are observed to melt-out and form embryonic geometrical ridge networks at the base of a terrestrially grounded ice cliff. Ridge networks are also located at the terrestrial margins of Tunabreen, neighboring Von Postbreen, and in a submarine position within Tempelfjorden. Analysis of network characteristics allows these ridges to be linked to different formational mechanisms of their parent debris-rich englacial structures. This in turn provides an insight into variations in the dominant tectonic stress regimes acting across the glacier during surges.

  14. Treatment of thyroid follicular carcinoma. (United States)

    Ríos, Antonio; Rodríguez, José M; Parrilla, Pascual


    Differentiated thyroid carcinoma includes 2 different tumor types, papillary (PC) and follicular carcinoma (FC), and although similar, their prognosis is different. FC is uncommon, and this has led to it often being analyzed together with PC, and therefore the true reality of this tumor is difficult to know. As a result, the diagnostic and therapeutic management and the prognostic factors in differentiated carcinoma are more predictive of PC than FC. In this review we analyze the current state of many of the therapeutic aspects of this pathology. The best surgical technique and the usefulness of associated lymphadenectomy is also analyzed. Regarding post-surgical ablation with 131I, the indications, doses and usefulness are discussed. For the remaining therapies we analyze the few indications for radiotherapy and chemotherapy, and of new drugs such as tyrosine kinase inhibitors.

  15. Follicular Bronchiolitis: A Literature Review (United States)

    Okafor, Ndubuisi C.; Ramirez, Jose F.; Smolley, Laurence


    Follicular bronchiolitis (FB) also known as hyperplasia of the bronchial associated lymphoid tissue (BALT), or bronchiolar nodular lymphoid hyperplasia, is an entity characterized by the development of lymphoid follicles with germinal centers in the walls of small airways. FB is thought to be caused by antigenic stimulation of BALT, followed by a polyclonal lymphoid hyperplasia. It is currently classified as one of the reactive pulmonary lymphoid disorders in a group known as the lymphoproliferative pulmonary diseases (LPDs). FB is a pathological diagnosis that can be seen in several clinical settings, including connective tissue diseases, immunodeficiency states, autoimmune diseases, infections, obstructive airway diseases, as well as several types of interstitial lung diseases (ILDs). Its characteristics need to be carefully identified and differentiated from other closely related diseases in the group of LPDs due to significant differences in treatment and prognosis. PMID:26500941

  16. New drugs for follicular lymphoma. (United States)

    Sorigue, Marc; Ribera, Josep-Maria; Motlló, Cristina; Sancho, Juan-Manuel


    Despite the improvement in prognosis since the advent of rituximab, follicular lymphoma is still incurable and remains the cause of death of most afflicted patients. With the expanding knowledge of the pathogenesis of B-cell malignancies, in the last few years a plethora of new therapies acting through a variety of mechanisms have shown promising results. This review attempts to analyze the evidence available on these new drugs, which include new monoclonal antibodies and immunoconjugates, the anti-angiogenic and immunomodulatory agent lenalidomide, the proteasome inhibitor bortezomib, inhibitors of B-cell receptor pathway enzymes, such as ibrutinib, idelalisib, duvelisib and entospletinib, BCL2 inhibitors and checkpoint inhibitors. We conclude that despite the high expectations around the new therapeutic options for patients with refractory disease, these new drugs have side effects that require caution with their use, particularly in light of the still short follow up and the lack of both randomized trials and data on combination regimens.


    Institute of Scientific and Technical Information of China (English)

    ZHAO Gui-lian; YANG jian-dong; XU Yuan-jie; LI Jin-ping


    When using the draft-tube vacuum to be less than 8.0m as the rule to set a tailrace surge tank, a mixing function that describes the process of water-hammer vacuum and velocity-head vacuum varied with time is proposed, on the assumption that the guide vane of the hydraulic turbine and the turbine discharge were all changed linearly. An exact maximum of the draft-tube vacuum for the first-phase water-hammer and the last-phase water-hammer is obtained. Finally a much more reasonable formula of critical tailrace length is derived. The results of two cases show that the formula proposed can determine correctly and reasonably whether a tailrace surge tank is needed or not, and are more suitable for project design than the formula suggested by the specification.

  18. Reconnaissance level study Mississippi storm surge barrier

    NARCIS (Netherlands)

    Van Ledden, M.; Lansen, A.J.; De Ridder, H.A.J.; Edge, B.


    This paper reports a reconnaissance level study of a storm surge barrier in the Mississippi River. Historical hurricanes have shown storm surge of several meters along the Mississippi River levees up to and upstream of New Orleans. Future changes due to sea level rise and subsidence will further

  19. Influence of Surge on Extreme Roll Amplitudes

    DEFF Research Database (Denmark)

    Vidic-Perunovic, Jelena; Rognebakke, Olav; Pedersen, Preben Terndrup


    Interference of the wave-induced ship surge motion with roll dynamics has been studied. The surge motion has been included in a previously derived hydrodynamic roll prediction model in order to account for the ship speed variation due to the longitudinal incident wave pressure force. Depending on...

  20. Reconnaissance level study Mississippi storm surge barrier

    NARCIS (Netherlands)

    Van Ledden, M.; Lansen, A.J.; De Ridder, H.A.J.; Edge, B.


    This paper reports a reconnaissance level study of a storm surge barrier in the Mississippi River. Historical hurricanes have shown storm surge of several meters along the Mississippi River levees up to and upstream of New Orleans. Future changes due to sea level rise and subsidence will further inc

  1. Compression station anti-surge system considerations

    Energy Technology Data Exchange (ETDEWEB)

    Kurz, Rainer; White, Robert C. [Solar Turbines Incorporated, Houston, TX (United States)


    Centrifugal compressor surge and its prevention have drawn significant attention in the literature. An important aspect of surge avoidance lies in the design of the compressor station and, in particular, the piping upstream and downstream of the compressor. Most anti-surge systems are perfectly capable of avoiding surge during normal operating conditions. However, unplanned emergency shutdowns present a significant challenge, and surge avoidance in these cases depends to a large degree on the station layout. Furthermore, the concepts used in the anti surge system (valves, piping, coolers) also impact the start-up of the station, or of individual units of the station. In this paper a simplified surge control system model is presented and used to develop simpler rules that help with proper sizing of upstream and downstream piping systems, as well as the necessary control element. Since the design of the surge control and recycle system also affects the start-up of units and stations, start-up considerations for stations with and without cooled recycle loops are discussed. (author)

  2. Luminescence dating of storm-surge sediment

    NARCIS (Netherlands)

    Cunningham, A.C.


    Geological evidence of storm surges has the potential to provide vital information on storm-surge risk. Sediment from the coastal dunes of the Netherlands contains evidence of extreme floods that occurred before reliable measurements of water level began. For these sediments to be useful in flood-ri

  3. Conductive surge testing of circuits and systems (United States)

    Richman, P.


    Techniques are given for conductive surge testing of powered electronic equipment. The correct definitions of common and normal mode are presented. Testing requires not only spike-surge generators with a suitable range of open-circuit voltage and short-circuit current waveshapes, but also appropriate means, termed couplers, for connecting test surges to the equipment under test. Key among coupler design considerations is minimization of fail positives resulting from reduction in delivered surge energy due to the coupler. Back-filters and the lines on which they are necessary, are considered as well as ground-fault and ground potential rise. A method for monitoring delivered and resulting surge waves is mentioned.

  4. Development and Evaluation of Storm Surge Ensemble Forecasting for the Philippines Using JMA Storm Surge Model (United States)

    Lapidez, J. P. B.; Tablazon, J. P.; Lagmay, A. M. F. A.; Suarez, J. K. B.; Santiago, J. T.


    The Philippines is one of the countries most vulnerable to storm surge. It is located in the North-western Pacific basin which is the most active basin in the planet. An average of 20 tropical cyclones enters the Philippine area of responsibility (PAR) every year. The archipelagic nature of the country with regions having gently sloping coasts and shallow bays also contribute to the formation of extreme surges. Last November 2013, storm surge brought by super typhoon Haiyan severely damaged several coastal regions in the Visayan Islands. Haiyan left more than 6 300 casualties and damages amounting to more than $ 2 billion. Extreme storm surge events such as this highlight the need to establish a storm surge early warning system for the country. This study explores the development and evaluation of storm surge ensemble forecasting for the Philippines using the Japan Meteorological Agency (JMA) storm surge model. 36-hour, 24-hour, and 12-hour tropical cyclone forecasts are used to generate an ensemble storm surge forecast to give the most probable storm surge height at a specific point brought by an incoming tropical cyclone. The result of the storm surge forecast is compared to tide gauge record to evaluate the accuracy. The total time of computation and dissemination of forecast result is also examined to assess the feasibility of using the JMA storm surge model for operational purposes.

  5. The evolution of a submarine landform record following recent and multiple surges of Tunabreen glacier, Svalbard (United States)

    Flink, Anne Elina; Noormets, Riko; Kirchner, Nina; Benn, Douglas I.; Luckman, Adrian; Lovell, Harold


    This study focuses on the glacial landform record associated with recent surge events of Tunabreen - a calving tidewater glacier in Tempelfjorden, Spitsbergen. Submarine geomorphology and recent terminal fluctuations of Tunabreen's glacier front were studied using high-resolution multibeam-bathymetric data and a range of published and remote-sensing sources, including topographic maps, satellite images and aerial photographs. The retreat moraines in the inner part of Tempelfjorden have been correlated with glacier terminus positions during retreat from the 2004 surge maximum. Glacier surface velocity and ice-front positions derived from high-resolution TerraSAR-X satellite data show ice movements at the glacier front during minor advances of the front in winter when calving is suppressed. This suggests that the moraines have formed annually during quiescent phase winter advances. Tunabreen has experienced three surges since the Little Ice Age (LIA). This is in contrast with most Svalbard surging glaciers which have long quiescent phases and have typically only undergone one or two surges during this time. The landform record in Tempelfjorden is distinguished from previously studied glacier-surge landsystems by four, well-preserved sets of landform assemblages generated by the LIA advance and three subsequent surges, all of which partly modify earlier landform records. Based on the unique landform record in Tempelfjorden, a new conceptual landsystem model for frequently surging glaciers has been put forward improving our understanding of the dynamics of the surging glaciers and, most importantly, how they can be distinguished from the climatically-controlled glaciers in the geological record.

  6. An Analysis of Air Force Systems Command’s Industrial Surge Preparedness Planning. (United States)


    have you taken related to suroe preparedness planning? Only three participants stated that they had taken the * basic production management courses AFIT...program phase was/(will) surge planning initially (be) put on contract? a. Suroe not applicable b. Concept Exploration c. Demonstration/Validation d...constantly. (2) Bad answers - Surge is problem in avionics only if suroes requires more test equipment to build upon to suroe rate. 7 esl equipment at least

  7. An Open-Label, Multicenter, Phase 1/2 Study of E7438 (EZH2 Histone Methyl Transferase [HMT] Inhibitor) as a Single Agent in Subjects With Advanced Solid Tumors or With B-cell Lymphomas (United States)


    B-cell Lymphomas (Phase 1); Advanced Solid Tumors (Phase 1); Diffuse Large B-cell Lymphoma (Phase 2); Follicular Lymphoma (Phase 2); Transformed Follicular Lymphoma; Primary Mediastinal Large B-Cell Lymphoma

  8. Study on the storm surges induced by cold waves in the Northern East China Sea (United States)

    Mo, Dongxue; Hou, Yijun; Li, Jian; Liu, Yahao


    Cold wave, a kind of severe weather system, can bring strong wind and induce significant sea level rise to the Northern East China Sea. Based on CFSR data, the study shows the monthly distributions of invaded days and the spatiotemporal distributions of cold-wave wind direction and wind speed. A three-dimensional numerical model (ROMS) was developed to study storm surges induced by cold waves. The role of wind direction, wind speed, wind duration, extratropical cyclone and tide-surge interaction is investigated by conducting different sensitivity experiments. The results indicate that storm surges mainly happen at the coasts perpendicular to the wind directions. Surge range and time lag are related to the geometry of the basin and the continental shelf. The response of the sea-level fluctuations to cold wave indicates that there is a positive correlation between crests and wind speed, a negative correlation between troughs and wind speed, but no obvious correlations to wind duration. Coupled weather cold waves, which yield a larger range and a multi-peak structure of surges, can be classified according to cold wave tracks and extratropical cyclones. The tide-surge interaction has an obvious and different effect on the magnitudes and phases of storm surges for different tidal stages.

  9. Cold Surge Activity Over the Gulf of Mexico in a Warmer Climate

    Directory of Open Access Journals (Sweden)

    Edgar Perez Perez


    Full Text Available Cold surges are a dominant feature of midlatitude tropical interaction. During the North Hemisphere (NH winter, midlatitude waves propagating from the Rocky Mountains into the Gulf of Mexico result in cold surges, also known as Nortes or Tehuantepecers, associated with severe weather over the southern part of Mexico. The magnitude of their intense surface winds, precipitation and drops in surface temperature depends on the characteristics of the midlatitude wave propagating into the tropics. The high spatial resolution (20km X 20km version of the TL959L60-AGC Model of the Meteorological Research Institute of Japan is used to examine changes in cold surge activity under the A1B greenhouse gas emission scenario for the 2080 - 2099 period. The model realistically reproduces the spatial and temporal characteristics of cold surges for the 1980 - 1989 control period. The effect of changes in baroclinicity, static stability and mean flow over North America suggest that in a warmer climate, increased cold surge activity over the Gulf of Mexico would occur. However, these systems would have shorter wavelength (higher phase speeds and shorter lifespans that could reduce the total amount of winter precipitation. The increased frequency of cold surges over the Gulf of Mexico would be a consequence of weaker baroclinicity and static stability in the lower troposphere over the cold surge genesis region, along with more dominant westerly winds, resulting from ENSO-like conditions in the atmospheric circulations over North America.

  10. Winter speed-up of two surging glaciers in West Kunlun Shan, Northwestern Tibet (United States)

    Yasuda, T.; Furuya, M.


    We detected winter speed-up of two surging glaciers in the West Kunlun Shan (WKS), based on satellite Synthetic Aperture Radar (SAR) images since 2007. Surging glacier is a surge-type glacier in the active phase, flowing rapidly and transporting ice masses into the down-glaciers. The WKS is located in northwestern Tibetan Plateau (TP) and is one of the driest and the coldest place around TP. Accumulation and ablation mostly occur in summer season from May to August [Zhang et al., 1989; Maussion et al., 2014]. Zhang et al. (1989) estimated the annual average precipitation and temperature near the equilibrium line altitude (5930 m) is 300 mm and -13.9 deg. C, respectively. Under this sub-polar environment, polythermal glaciers exist in the WKS [Aniya, 2008]. We detected development of two surging flow with unprecedented temporal resolution up to 11 days. The two surging initiated around 2000 and continued by 2015. Surging flow accelerated at least 200 m/year. Moreover, it seasonally fluctuated their flow speed up to 200% in early winter against those in spring to early summer. The observed seasonal modulation in the surface velocities strongly suggests the presence of surface meltwater and subsequent rerouting through englacial and subglacial drainage system under a years-long surging glacier in the sub-polar environment.

  11. The dynamics of surge in compression systems

    Indian Academy of Sciences (India)

    A N Vishwanatha Rao; O N Ramesh


    In air-compression systems, instabilities occur during operation close to their peak pressure-rise capability. However, the peak efficiency of a compression system lies close to this region of instability. A surge is a violent mode of instability where there is total breakdown of flow in the system and pressure-rise capability is lost drastically. Generally, all compression systems operate with a margin defined as the ‘surge margin’, and, consequently, system operational efficiency is lower. It is of interest to study compression-system surge to understand its dynamics in order to operate compression systems close to the instability for achieving high efficiency safely without encountering surge. Unsteady pressure data from a compression system, captured during surge oscillations, reveal many aspects of flow physics and are analysed to understand the surge dynamics of the system. A set of controlled experiments was conducted with a simple desktop experimental test set-up and essential aspects of surge dynamics have been characterised.

  12. Storm surge and tidal range energy (United States)

    Lewis, Matthew; Angeloudis, Athanasios; Robins, Peter; Evans, Paul; Neill, Simon


    The need to reduce carbon-based energy sources whilst increasing renewable energy forms has led to concerns of intermittency within a national electricity supply strategy. The regular rise and fall of the tide makes prediction almost entirely deterministic compared to other stochastic renewable energy forms; therefore, tidal range energy is often stated as a predictable and firm renewable energy source. Storm surge is the term used for the non-astronomical forcing of tidal elevation, and is synonymous with coastal flooding because positive storm surges can elevate water-levels above the height of coastal flood defences. We hypothesis storm surges will affect the reliability of the tidal range energy resource; with negative surge events reducing the tidal range, and conversely, positive surge events increasing the available resource. Moreover, tide-surge interaction, which results in positive storm surges more likely to occur on a flooding tide, will reduce the annual tidal range energy resource estimate. Water-level data (2000-2012) at nine UK tide gauges, where the mean tidal amplitude is above 2.5m and thus suitable for tidal-range energy development (e.g. Bristol Channel), were used to predict tidal range power with a 0D modelling approach. Storm surge affected the annual resource estimate by between -5% to +3%, due to inter-annual variability. Instantaneous power output were significantly affected (Normalised Root Mean Squared Error: 3%-8%, Scatter Index: 15%-41%) with spatial variability and variability due to operational strategy. We therefore find a storm surge affects the theoretical reliability of tidal range power, such that a prediction system may be required for any future electricity generation scenario that includes large amounts of tidal-range energy; however, annual resource estimation from astronomical tides alone appears sufficient for resource estimation. Future work should investigate water-level uncertainties on the reliability and

  13. Physical attributes of hurricane surges and their role in surge warning (United States)

    Irish, J. L.


    In the last decade, the US has experienced some of its largest surges and hurricane-related damages on record. Effective evacuation in advance of a hurricane strike requires accurate estimation of the hurricane surge hazard that effectively conveys risk not only to government decision makers but also to the general public. Two primary challenges exist with the current structure for surge warning. First, existing computational methods for developing accurate, quantitative surge forecasts, namely surge height and inundation estimation, are limited by time and computational resources. Second, due primarily to the popularity and wide use of the Saffir-Simpson wind scale to convey the complete hurricane hazard, the public's perception of surge hazard is inaccurate. Here, we use dimensionless scaling and hydrodynamics arguments to quantify the influence of hurricane variables and regional geographic characteristics on the surge response. It will be shown that hurricane surge primarily scales with the hurricane's central pressure, and size and with continental shelf width at the landfall location (Irish et al. 2009, Nat. Haz.; Song et al. in press, Nat. Haz.). Secondary influences include the hurricane's forward speed and path. The developed physical scaling is applied in two ways: (1) as a means for expanding the utility of computational simulations for real-time surge height forecasting and (2) as a means to convey relative surge hazard via a readily evaluated algebraic surge scale. In the first application, the use of this physical scaling to develop surge response functions (SRF) enables instantaneous algebraic calculation of maximum surge height at any location of interest for any hurricane meteorological condition, without loss of accuracy gained via high-resolution computational simulation. When coupled with joint probability statistics, the use of SRFs enables rapid development of continuous probability density functions for probabilistic surge forecasting (Irish

  14. Storm surge evolution and its relationship to climate oscillations at Duck, NC (United States)

    Munroe, Robert; Curtis, Scott


    Coastal communities experience increased vulnerability during storm surge events through the risk of damage to coastal infrastructure, erosion/deposition, and the endangerment of human life. Policy and planning measures attempt to avoid or mitigate storm surge consequences through building codes and setbacks, beach stabilization, insurance rates, and coastal zoning. The coastal emergency management community and public react and respond on shorter time scales, through temporary protection, emergency stockpiling, and evacuation. This study utilizes time series analysis, the Kolmogorov-Smirnov (K-S) test, Pearson's correlation, and the generalized extreme value (GEV) theorem to make the connection between climate oscillation indices and storm surge characteristics intra-seasonally to inter-annually. Results indicate that an El Niño (+ENSO), negative phase of the NAO, and positive phase of the PNA pattern all support longer duration and hence more powerful surge events, especially in winter. Increased surge duration increases the likelihood of extensive erosion, inland inundation, among other undesirable effects of the surge hazard.

  15. Emergency department surge capacity: recommendations of the Australasian Surge Strategy Working Group. (United States)

    Bradt, David A; Aitken, Peter; Fitzgerald, Gerry; Swift, Roger; O'Reilly, Gerard; Bartley, Bruce


    For more than a decade, emergency medicine (EM) organizations have produced guidelines, training, and leadership for disaster management. However, to date there have been limited guidelines for emergency physicians (EPs) needing to provide a rapid response to a surge in demand. The aim of this project was to identify strategies that may guide surge management in the emergency department (ED). A working group of individuals experienced in disaster medicine from the Australasian College for Emergency Medicine Disaster Medicine Subcommittee (the Australasian Surge Strategy Working Group) was established to undertake this work. The Working Group used a modified Delphi technique to examine response actions in surge situations and identified underlying assumptions from disaster epidemiology and clinical practice. The group then characterized surge strategies from their corpus of experience; examined them through available relevant published literature; and collated these within domains of space, staff, supplies, and system operations. These recommendations detail 22 potential actions available to an EP working in the context of surge, along with detailed guidance on surge recognition, triage, patient flow through the ED, and clinical goals and practices. The article also identifies areas that merit future research, including the measurement of surge capacity, constraints to strategy implementation, validation of surge strategies, and measurement of strategy impacts on throughput, cost, and quality of care.

  16. Glacier surge mechanism: 1982-1983 surge of variegated glacier, alaska. (United States)

    Kamb, B; Raymond, C F; Harrison, W D; Engelhardt, H; Echelmeyer, K A; Humphrey, N; Brugman, M M; Pfeffer, T


    The hundredfold speedup in glacier motion in a surge of the kind the kind that took place in Variegated Glacier in 1982-1983 is caused by the buildup of high water pressure in the basal passageway system, which is made possible by a fundamental and pervasive change in the geometry and water-transport characteristics of this system. The behavior of the glacier in surge has many remarkable features, which can provide clues to a detailed theory of the surging process. The surge mechanism is akin to a proposed mechanism of overthrust faulting.

  17. Validation of a surge model by full scale testing

    NARCIS (Netherlands)

    Slot, H.J.; Meulendijks, D.; Smeulers, J.P.M.


    Surge of turbo compressors can cause large stepwise changes in flow and pressure, which can potentially damage the compressor and any equipment that is in direct connection with the compressor. Surge is usually avoided by an anti surge controller (ASC). However, in spite of the ASC surge cycles may

  18. Validation of a surge model by full scale testing

    NARCIS (Netherlands)

    Smeulers, J.P.M.; Slot, H.J.; Meulendijks, D.


    Surge of turbo compressors can cause large stepwise changes in flow and pressure, which can potentially damage the compressor and any equipment that is in direct connection with the compressor. Surge is usually avoided by an anti surge controller (ASC). However, in spite of the ASC surge cycles may

  19. Tsivat Basin conduit system persists through two surges, Bering Piedmont Glacier, Alaska (United States)

    Fleisher, P.J.; Cadwell, D.H.; Muller, E.H.


    The 1993-1995 surge of Bering Glacier, Alaska, occurred in two distinct phases. Phase 1 of the surge began on the eastern sector in July, 1993 and ended in July, 1994 after a powerful outburst of subglacial meltwater into Tsivat Lake basin on the north side of Weeping Peat Island. Within days, jokulhlaup discharge built a 1.5 km2 delta of ice blocks (25-30 m) buried in outwash. By late October 1994, discharge temporarily shifted to a vent on Weeping Peat Island, where a second smaller outburst dissected the island and built two new sandar. During phase 2, which began in spring 1995 and ended within five months, continuous discharge issued from several vents along the ice front on Weeping Peat Island before returining to the Tsivat Basin. Surge related changes include a five- to six-fold increase in meltwater turbidity; the redirection of supercooled water in two ice-contact lakes; and an increase in the rate of glaciolacustrine sedimentation. US Geological Survey aerial photos by Austin Post show large ice blocks in braided channels indicating excessive subglacial discharge in a similar position adjacent to Weeping Peat Island during the 1966-1967 surge. During the subsequent three decades of retreat, the location of ice-marginal, subglacial discharge vents remained aligned on a linear trend that describes the position of a persistent subglacial conduit system. The presence of a major conduit system, possibly stabilized by subglacial bedrock topography, is suggested by: 1) high-level subglacial meltwater venting along the northern side of Weeping Peat Island during the 1966-1967 surge, 2) persistent low-level discharge between surges, and 3) the recurrence of localizing meltwater outbursts associated with both phases of the 1993-1005 surge.

  20. Cold basal conditions during surges control flow of fringing Arctic ice caps in Greenland (United States)

    Cook, Samuel; Christoffersen, Poul; Todd, Joe; Palmer, Steven


    Fringing ice caps separated from larger ice sheets are rarely studied, yet they are an important part of earth's cryosphere, which has become the largest source of global sea-level rise. Understanding marginal ice caps is crucial for being able to predict sea-level change as they are responsible for up to 20% of Greenland's mass loss for 2003-2008. Studies of fringing ice caps can furthermore provide useful insights into processes operating on glaciers that surge. Surging has been the focus of much recent glaciological work, especially with reference to thermal evolution of polythermal glaciers in High Mountain Asia and the High Arctic. This has shown that the classic divide between hydrologically-controlled surges ('hard-bed') in Alaska and thermally-regulated ('soft-bed') surges elsewhere is less stark than previously assumed. Studying marginal ice caps can therefore be valuable in several ways. The largest fringing ice cap in Greenland is Flade Isblink. Previous work has established that this ice cap is showing a range of dynamic behaviour, including subglacial lake drainage and varied patterns of mass-balance change. In particular, a substantial surge, assumed to be caused by a version of the thermally-regulated mechanism, occurred between 1996 and 2000, making the ice cap a useful case study for investigating this process. Here we investigate the surge on Flade Isblink using the open-source, Full-Stokes model Elmer/Ice to invert for basal conditions and englacial temperatures using the adjoint method. We specifically study steady-state conditions representative of the active surge phase in 2000, and the subsequent quiescent phase, using patterns of surface velocity observed in 2000, 2005, 2008 and 2015. Under constant geometry, temperature and geothermal heat, it is shown that surging increases basal freezing rates by over 60% across an area that is twice as large as the area over which the bed freezes in the quiescent phase. The process responsible for this

  1. A comparison of adrenal gland function in lactating dairy cows with or without ovarian follicular cysts. (United States)

    Silvia, William J; McGinnis, Angela S; Hatler, T Ben


    Two experiments were conducted to determine if adrenal secretion of steroids differed between cows that formed ovarian follicular cysts and normal cycling cows. In experiment 1, lactating Jersey and Holstein cows were diagnosed as having ovarian follicular cysts (follicle diameter >or=20 mm) by rectal palpation. Following diagnosis, ovaries were examined by transrectal ultrasonography three times weekly to detect subsequent ovulation (n=8) or new cyst formation (n=9). Venous blood samples were collected daily to quantify circulating concentrations of cortisol and progesterone. The average concentration of cortisol during the 10-day period prior to ovulation was not different from the concentration prior to the formation of a new cyst. In experiment 2, secretion of cortisol and progesterone was examined in cows with ovarian follicular cysts (n=4) and cyclic, control cows in the follicular phase of the estrous cycle (n=4). An adrenocorticotropic hormone (ACTH) challenge was administered to cystic cows 4-7 days after new cyst formation and to cyclic cows in the follicular phase of the cycle (36 h after induction of luteolysis). Jugular venous blood samples were collected at -60, -30, 0, +10, +20, +30, +60, +90, +120, +180, +240, +300 and +360 minutes relative to ACTH administration. A rapid increase in both cortisol and progesterone was observed immediately following administration of ACTH in each treatment group. Peak concentrations of both steroids were achieved within 60 minutes after administration of ACTH. Concentrations of cortisol and progesterone did not differ between cystic and cyclic cows. In summary, no differences in adrenal function were detected between normal cycling cows and cows with ovarian follicular cysts.

  2. Model simulation of storm surge potential for Andaman islands

    Digital Repository Service at National Institute of Oceanography (India)

    Kumar, V.S.; RameshBabu, V.; Babu, M.T.; Dhinakaran, G.; Rajamanickam, G.V.

    ) for storm surge forecasting at the eastern coast of India. Flather (1994) has applied another analytical model of Holland (1980) for wind and pressure fields in the case of surge simulation, forced by April 1991 Bangladesh storm. The basic atmospheric... parameters remain the same in all the parameterization schemes of storm wind field. Storm Surge Model Storm surge operational models are in use for a long time for forecasting and warning of storm surge disasters bordering the coasts in the parts of northern...

  3. Twelve-year cyclic surging episode at Donjek Glacier in Yukon, Canada (United States)

    Furuya, M.; Abe, T.; Sakakibara, D.


    Surge-type glaciers exhibit several-fold to orders-of-magnitude speed-up during the short active phase, resulting in km-scale terminus advance. Although there are many surge-type glaciers near the border of Alaska and the Yukon, the generation mechanisms remain uncertain because of limited and few continuous observations. To better understand the surge dynamics and predict the next event, it is essential to examine the entire surge cycles. Here we use Landsat optical imageries to reveal the long-term evolutions, and report three surging episodes at Donjek Glacier in Yukon, Canada. Using the Landsat images, we found three surging events in 1989, 2001, and 2013. In the 2001 event, the surface speed significantly increased by up to 4.5 m/d; during the quiescent phases it was ~0.5 m/d at the terminus. While the duration of active phase is about 4~5 and 2~3 year in the 2001 and 2013 events, the period in the 1989 event is unclear because of the lack of high temporal resolution data. Remarkably, the surging area is limited to the ~20-km section from the terminus instead of the entire glacier. Moreover, we examined the terminus area changes from 1975 to 2014. Although the area has been secularly decreasing probably due to the tread of global warming, it has also revealed four significant fluctuations during the nearly forty years. Comparing the speed and the area changes, the three speed-up events correspond to the terminus area fluctuations with a few time lags. It turns out that the surge event has been quite regularly repeating every twelve years. Although the behavior is rather similar to that in Svalbard glaciers in terms of maximum speed and unclear initiation season, the recurrence interval is much shorter than other nearby surges. Considering that the surge events seem to have initiated around significantly narrower area than upstream, the strong valley constriction may control the regularity as well as the twelve-year recurrence time.

  4. Switching surge overvoltages on a feeding system of a MAGLEV train; Jiki fujoshiki tetsudo no kidenkei ni okeru kaihei surge kaden`atsu

    Energy Technology Data Exchange (ETDEWEB)

    Muragishi, H. [Nippon Yusoki Co. Ltd., Kyoto (Japan); Nakamura, Y.; Muraoka, N.; Ametani, A. [Doshisha Univ., Kyoto (Japan)


    Discussions using simulations were given on surge overvoltages and earth fault surge overvoltage associated with operation of a section switchgear in a feeding system of a MAGLEV train. Results of the discussions may be summarized as follows: throw-in surge overvoltage caused by the section switchgear is about 25 kV at maximum on the coil and about 15 kV on the cable sheath. The coil overvoltage increases as the closer to 90 degrees the throw-in phase approaches, and the greater the power supply frequency increases. The cable sheath overvoltage, however, is not affected by these environments. Breaking surge overvoltage caused by the section switchgear reaches 115 kV on the coil and about the same value on the cable sheath when the breaking current is 50 A. Earth fault surge overvoltage due to cable fault is 24 kV at maximum on the coil, while it reaches 32 kV on the cable sheath. The cable sheath overvoltage depends largely on sheath installing conditions. These overvoltages can be suppressed sufficiently lower than insulation levels of each device by installing arresters. 17 refs., 18 figs.

  5. Follicular lymphoma of the ocular adnexal region

    DEFF Research Database (Denmark)

    Rasmussen, Peter Kristian; Ralfkiaer, E.; Prause, J.U.


    with ocular adnexal follicular lymphoma were identified. Fourteen (58%) of the patients were females. The median age was 63 years (range: 42–96 years). Eleven (46%) of the patients had primary ocular adnexal lymphoma, seven (29%) had an ocular adnexal lesion in conjunction with a concurrent systemic lymphoma...


    The aim of the present study was to isolate chicken follicular dendritic cells (FDC). A combination of methods involving panning, iodixanol density gradient centrifugation, and magnetic cell separation technology made it possible to obtain functional FDC from the cecal tonsils from chickens, which h...

  7. On the 'real' mass loss of some surging glaciers in the central Karakoram (United States)

    Paul, Frank


    Several assessments of the mass changes of surging glaciers in the central Karakoram (and elsewhere) have shown near-zero changes over the typically decadal-long observation periods. This is in line with the theory that during a surge mass from a reservoir area is moved down-glacier to a receiving area with limited overall change. The resulting elevation changes of the glacier surface as determined by differencing DEMs from two points in time show a typical pattern (decreasing at higher, increasing at lower elevations) with a possible strong frontal advance (km scale) of the terminus. However, this is only half of the story as the observed mass gain at lower elevations is ultimately also a loss. This loss can only be determined when it is calculated separately and when sufficiently precise DEMs from the beginning and the end of a surge are available for each individual glacier. As the latter are hard to obtain, this study presents a simplified geomorphometric approach to approximate a potential maximum surge volume for 20 glaciers with a channel-like glacier fore field. By assuming a semi-elliptical cross-section of the channels, simple measurements of their average width, height and length in Google Earth provide the volume. Further glacier-specific parameters are taken from a recently compiled glacier inventory (area, slope) and Google Earth (minimum length and highest/lowest elevations) to obtain characteristics such as elevation ranges and volume. The average annual specific volume loss for each glacier is then determined by dividing the calculated surge volumes by the respective glacier area and the duration of a full surge cycle (obtained in a previous study). Which glacier area (minimum?) and surge duration (only the active phase?) have to be taken for this calculation is likely a matter of debate. With surge distances between about 1 and 5 km and channel widths (heights) between 300 and 700 (50 and 125) m, the surge volumes vary between 15 and 250 (mean 80

  8. Familial Follicular-Cell Derived Carcinoma

    Directory of Open Access Journals (Sweden)

    Eun Ju eSon


    Full Text Available Follicular cell-derived well-differentiated thyroid cancer, papillary (PTC and follicular thyroid carcinomas (FTC compose 95% of all thyroid malignancies. Familial follicular cell-derived well-differentiated thyroid cancers contribute to 5% of those cases. These familial follicular cell derived carcinomas or non-medullary thyroid carcinomas (NMTC divide into two clinical-pathological groups. One group, syndromic-associated, composed by predominately non-thyroidal tumors, is comprised of Pendred syndrome, Warner syndrome, Carney complex type 1, PTEN-hamartoma tumor syndrome (Cowden disease; PHTS, familial adenomatous polyposis (FAP/Gardner syndrome. Additionally other less established links correlated to the development of follicular cell-derived tumors have also included Ataxia-teleangiectasia syndrome, McCune Albright syndrome, and Peutz-Jeghers syndrome. The subsequent group encompasses syndromes typified by non-medullary thyroid carcinomas or NMTC, as well as, pure familial (f PTC with or without oxyphilia, fPTC with multinodular goiter and fPTC with papillary renal cell carcinoma. This heterogeneous group of diseases has not a established genotype-phenotype correlation as the well-known genetic events identified in the familial C-cell-derived tumors or medullary thyroid carcinomas (MTC. Clinicians should be have the knowledge to identify the likelihood of a patient presenting with thyroid cancer having an additional underlying familial syndrome stemming from characteristics through morphological findings that would alert the pathologist to have the patient undergo subsequent molecular genetics evaluations. This review will discuss the clinical and pathological findings of the patients with familial papillary thyroid carcinoma, such as familial adenomatous polyposis, Carney complex, Werner syndrome, and Pendred syndrome and the heterogeneous group of familial papillary thyroid carcinoma.

  9. From solitary wave to traveling surge

    Institute of Scientific and Technical Information of China (English)



    The solution of kinetic Alfven wave under action of anomalous resistance has two branches: the slow wave, VPsurge and the fast wave VP>VA cosθ will be in a wave-broken state. Such traveling surge structure is a typical self-organization phenomenon and its wave form is determined by parameter β which represents the magnitude of resistance. High β leads to shock-like structure and low β to the appearance of some solitary waves in front of the shock. According to the study on solitary wave, shock wave and traveling surge in conjunction with self-organization of nonlinear dynamics, a general definition of wave can be given.

  10. Adaptive mesh refinement for storm surge

    KAUST Repository

    Mandli, Kyle T.


    An approach to utilizing adaptive mesh refinement algorithms for storm surge modeling is proposed. Currently numerical models exist that can resolve the details of coastal regions but are often too costly to be run in an ensemble forecasting framework without significant computing resources. The application of adaptive mesh refinement algorithms substantially lowers the computational cost of a storm surge model run while retaining much of the desired coastal resolution. The approach presented is implemented in the GeoClaw framework and compared to ADCIRC for Hurricane Ike along with observed tide gauge data and the computational cost of each model run. © 2014 Elsevier Ltd.

  11. Computer-assisted mapping of pyroclastic surges. (United States)

    Malin, M C; Sheridan, M F


    Volcanic hazard maps of surge boundaries and deposit thickness can be created by using a simplified eruption model based on an "energy line" concept of pyroclastic surge and flow emplacement. Computer image-processing techniques may be used to combine three-dimensional representations of the energy relations of pyroclasts moving under the influence of gravity (defined by an "energy cone") with digital topographic models of volcanoes to generate theoretical hazard maps. The deposit boundary and thickness calculated for the 18 May 1980 eruption of Mount St. Helens are qualitatively similar to those actually observed.

  12. Adaptive Mesh Refinement for Storm Surge

    CERN Document Server

    Mandli, Kyle T


    An approach to utilizing adaptive mesh refinement algorithms for storm surge modeling is proposed. Currently numerical models exist that can resolve the details of coastal regions but are often too costly to be run in an ensemble forecasting framework without significant computing resources. The application of adaptive mesh refinement algorithms substantially lowers the computational cost of a storm surge model run while retaining much of the desired coastal resolution. The approach presented is implemented in the \\geoclaw framework and compared to \\adcirc for Hurricane Ike along with observed tide gauge data and the computational cost of each model run.

  13. A phase plane graph based model of the ovulatory cycle lacking the "positive feedback" phenomenon

    Directory of Open Access Journals (Sweden)

    Kurbel Sven


    Full Text Available Abstract When hormones during the ovulatory cycle are shown in phase plane graphs, reported FSH and estrogen values form a specific pattern that resembles the leaning “&" symbol, while LH and progesterone (Pg values form a "boomerang" shape. Graphs in this paper were made using data reported by Stricker et al. [Clin Chem Lab Med 2006;44:883–887]. These patterns were used to construct a simplistic model of the ovulatory cycle without the conventional "positive feedback" phenomenon. The model is based on few well-established relations: hypothalamic GnRH secretion is increased under estrogen exposure during two weeks that start before the ovulatory surge and lasts till lutheolysis. the pituitary GnRH receptors are so prone to downregulation through ligand binding that this must be important for their function. in several estrogen target tissue progesterone receptor (PgR expression depends on previous estrogen binding to functional estrogen receptors (ER, while Pg binding to the expressed PgRs reduces both ER and PgR expression. Some key features of the presented model are here listed: High GnRH secretion induced by the recovered estrogen exposure starts in the late follicular phase and lasts till lutheolysis. The LH and FSH surges start due to combination of accumulated pituitary GnRH receptors and increased GnRH secretion. The surges quickly end due to partial downregulation of the pituitary GnRH receptors (64% reduction of the follicular phase pituitary GnRH receptors is needed to explain the reported LH drop after the surge. A strong increase in the lutheal Pg blood level, despite modest decline in LH levels, is explained as delayed expression of pituitary PgRs. Postponed pituitary PgRs expression enforces a negative feedback loop between Pg levels and LH secretions not before the mid lutheal phase. Lutheolysis is explained as a consequence of Pg binding to hypothalamic and pituitary PgRs that reduces local ER expression. When hypothalamic

  14. Storm surge and river interaction in etuaries (United States)

    Maskell, J.


    In coastal areas, particularly in regions developed on estuaries, extreme river flow can combine with storm surges to present a combined hazard. This combined risk is likely to be more prominent in estuaries where fluvial fresh water input comes from catchments in hilly regions where the dependence of extreme river discharge and sea level elevation can be most statistically significant (Svensson and Jones, 2004). The risk associated with these combined coastal hazards could increase due to climate change if there were an increase in the frequency of extreme weather events. The global (IPCC, 2007) and local (Woodworth et al., 2009) rise in mean sea-level will increase the magnitude of extreme sea levels and surges will act on a higher coastal sea level and therefore increase the risk to coastal property and infrastructure. This may be associated with an increase in precipitation during extreme storm events which will have a large impact on river flooding. Therefore, the need for accurate operational forecasting of storm events will increase with the focus shifting to changes in the extreme 'tail end' of the distribution of storm events. Ideally an operational model that integrates storm surge, wave and fluvial forecasting with inundation and simulates their combined influence would be most effective for planning with respect to flood plain development, evacuation and flood defence. Current operational storm surge models are typically based on two-dimensional depth-averaged shallow water equations (Flather, 2000). Inundation models often use an approximation of the original shallow water equations which neglect the inertial terms (Prestininzi et al., 2011). These 2D flood plain inundation models are often coupled with a 1D model of the main channel of a river or estuary which permits the exchange of mass but assumes a limited exchange of momentum (Bates et al., 2005). A finite volume model (FVCOM) is used to investigate the combined influence of storm surge and river

  15. Positive feedback stabilization of centrifugal compressor surge

    NARCIS (Netherlands)

    Willems, Frank; Heemels, W.P.M.H.; de Jager, Bram; Stoorvogel, Antonie Arij


    Stable operation of axial and centrifugal compressors is limited towards low mass flows due to the occurrence of surge. The stable operating region can be enlarged by active control. In this study, we use a control valve which is fully closed in the desired operating point and only opens to stabiliz

  16. Positive feedback stabilization of centrifugal compressor surge

    NARCIS (Netherlands)

    Willems, Frank; Heemels, W.P.M.H.; de Jager, Bram; Stoorvogel, Antonie Arij

    Stable operation of axial and centrifugal compressors is limited towards low mass flows due to the occurrence of surge. The stable operating region can be enlarged by active control. In this study, we use a control valve which is fully closed in the desired operating point and only opens to

  17. A new concept for glacial geological investigations of surges, based on High-Arctic examples (Svalbard) (United States)

    Lønne, Ida


    Svalbard is a key area for the investigation of glacial surges, and almost two centuries worth of field observations exists from this region. Studies have shown that the course of a surge and the associated formation of landforms are strongly influenced by basinal factors, and that the broad range of variables involved can hamper interpretations and comparisons. Based on a review of surges in Svalbard, a new concept for glacial geological investigations has been developed that combines ice-flows, ice-front movements, and morphostratigraphy. The concept is comprised of the following four elements: 1) classification based on the configuration and characteristics of the receiving basin, 2) division of the surge cycle into six stages, 3) guidelines for morphological mapping, and 4) use of an allostratigraphic approach for interpreting ice-front movements. In this context, delineation of the active phase is critical, which include the history of terminus movements, and four main categories of receiving basins are recognized. These are (A) terrestrial basins with deformable substrates, (B) terrestrial basins with poorly deformable substrates, (C) shallow water basins, and (D) deep water basins. The ice-front movement history is reconstructed by coupling information from the proglacial moraines (syn-surge), the supraglacial moraines (post-surge), and the associated traces of meltwater to the surge stages (I-VI). This approach has revealed a critical relationship between the termination of the active phase and three morphological elements, namely, the maximum ice-front position, the maximum moraine extent and the youngest proglacial moraine, which are unique for each of the basins A-D. The concept is thus a novel and more precise approach for mapping the active phase and the active phase duration, as shown by the ∼12-year long surge of Fridtjovbreen, where stage I was 30 months (inception), stage II was 54 months (ice-front advance), stage III was 12 months (stillstand

  18. Molecular photoacoustic imaging of follicular thyroid carcinoma

    DEFF Research Database (Denmark)

    Levi, Jelena; Kothapalli, Sri-Rajashekar; Bohndiek, Sarah


    Purpose To evaluate the potential of targeted photoacoustic imaging as a non-invasive method for detection of follicular thyroid carcinoma. Experimental Design We determined the presence and activity of two members of matrix metalloproteinase family (MMP), MMP-2 and MMP-9, suggested as biomarkers...... for malignant thyroid lesions, in FTC133 thyroid tumors subcutaneously implanted in nude mice. The imaging agent used to visualize tumors was MMP activatable photoacoustic probe, Alexa750-CXeeeeXPLGLAGrrrrrXK-BHQ3. Cleavage of the MMP activatable agent was imaged after intratumoral and intravenous injections...... With the combination of high spatial resolution and signal specificity, targeted photoacoustic imaging holds great promise as a noninvasive method for early diagnosis of follicular thyroid carcinomas....

  19. Synthetic Fentanyl Fueling Surge in Overdose Deaths: CDC (United States)

    ... Synthetic Fentanyl Fueling Surge in Overdose Deaths: CDC U.S. Surgeon ... News) -- Deaths from overdoses of the synthetic narcotic fentanyl have surged in recent years, U.S. health officials ...

  20. Immunotherapy with rituximab in follicular lymphomas. (United States)

    Saguna, Carmen; Mut, Ileana Delia; Lupu, Anca Roxana; Tevet, Mihaela; Bumbea, Horia; Dragan, Cornel


    Non-Hodgkin Lymphomas (NHL) represent a recent and fascinating domain of hemato-oncology, in which remarkable progress has been made. The conventional treatments of indolent lymphomas do not extend the survival rate, nor do they cure. Recent directions are centered on using several new drugs that are capable of overcoming the mechanisms that are resistant to recovery. The initiation of immunotherapy (Rituximab in 1997) seems to have changed the natural evolution of follicular lymphomas (FL). It is possible that resistance to healing in follicular lymphomas may be neutralized with Rituximab by suppressing STAT-1 positive macrophages that are present in the cellular microenvironment.Thereinafter, the re-evaluation of recent models of prognostic and therapeutic paradigmas that were used in FL became compulsory.The purpose of the paper is to compare the evolution of patients with follicular lymphoma and the period of response, according to the treatments. The study group consisted of the 71 patients diagnosed with follicular lymphoma, out of a total of 767 malignant lymphatic proliferations with B cells, for a period of 7 years (2002-2008), at the Hematology Department, Hospital Coltea, Bucharest and Hematology Department, Universitary Hospital, BucharestResults and conclusions: Combining chemotherapy with Rituximab had better results compared to the same chemotherapy, administered alone, both in induction and in case of relapse. The overall response rate in our study group was 74.7%, out of which 42.3% complete remissions. The overall response rate was 84.61% in the Rituximab group, compared to 68.88% in patients without Rituximab.

  1. Follicular bronchiolitis: a rare disease in children (United States)

    Kanık, Esra Toprak; Yılmaz, Özge; Türkeli, Ahmet; Şahin, Şebnem; Yüksel, Hasan


    Follicular bronchiolitis (FB) is a benign progressive lung disease. It is characterized with lymphoplasmocellular infiltration and hyperplastic follicles in the peribronchial areas in the small airways. Follicular bronchiolitis should be considered in cases where chronic cough, recurrent upper respiratory tract infections and progressive dyspnea are observed in children. The diagnosis should be supported by lung biopsy. A 8-year old female patient presented to our hospital with complaints including continuing cough and wheezing. Bilateral extensive rales and rhonchi in the lungs were heard on auscultation and lung graphy revealed reticuloglandular appearance. Bilateral extensive septal thickennings, reticulonodular appearance, patchy bronchiectasis, bronchiolectasis and peribronchial thickennings were found on high-resolution thoracal computarized tomography. A diagnosis of follicular bronchiolitis was made as a result of lung biopsy. Improvement was observed in the complaints and findings of our patient after methylprednisolone treatment. This patient was presented to emphasize rare interstitial lung diseases should also be considered in children who present with a clinical picture of chronic bronchial obstruction and do not respond to standard treatment. PMID:26078687

  2. Metastatic thyroid follicular carcinoma of masticator space

    Energy Technology Data Exchange (ETDEWEB)

    Gang, Tae In; Heo, Min Suk; An, Chang Hyeon; Lee, Sam Sun; Choi, Soon Chul; Park, Tae Won [College of Dentistry, Seoul National University, Seoul (Korea, Republic of); Choi, Mi [Department of Dental Radiology, College of Dentistry, Kyungpook National University, Daegu (Korea, Republic of)


    Follicular carcinomas are the second most common form of thyroid cancer, accounting for 10 to 20% of all thyroid cancers. Follicular carcinomas have a propensity to metastasize via the bloodstream, spreading to bone, lungs, liver, and elsewhere. We described the case of a 48-year-old woman who presented with swelling of the left pre auricular area, which was a consequence of a metastatic follicular carcinoma of the masticator space. Plain films showed ill defined erosive bony changes from the left condylar head to the mandibular notch. Contrast-enhanced CT images showed a well circumscribed round mass with well enhancement within left masticator space. On MR images, the mass was heterogenously hyperintense to the muscle on T2-weighted images and isointense or hyperintense to the muscle on T1-weighted images, and showed good enhancement on contrast-enhanced T1-weighted images. Upon microscopic examination, the metastatic mass was found to be composed of fairly uniform cells forming small follicles containing colloid, showing capsular and vascular invasion.

  3. The clinical development of obinutuzumab for the treatment of follicular lymphoma

    Directory of Open Access Journals (Sweden)

    Ma B


    Full Text Available Barbara Ma,1 Chaitra Ujjani2 1Department of Medicine, 2Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, Washington, DC, USA Abstract: Impressive progress has been made in recent decades for advanced-stage follicular lymphoma with the availability of anti-CD20 monoclonal antibodies, initially rituximab and more recently obinutuzumab. Obinutuzumab is a unique, third-generation, fully humanized glycoengineered IgG1 type II anti-CD20 monoclonal antibody. It has been shown to have increased antitumor activity compared to rituximab in preclinical studies, including whole-blood B-cell depletion assays, xenograft models, and primate models. This has spurred on the development of obinutuzumab through Phase I/II trials as monotherapy and in combination with chemotherapeutic agents and other targeted therapies. Its efficacy compared to rituximab and in rituximab-refractory disease has led to its continued development and eventual approval for the treatment of follicular lymphoma. Here in this review, we highlight the design and development of obinutuzumab in the treatment of advanced stage grade 1–3A follicular lymphoma and its future directions. Keywords: follicular lymphoma, obinutuzumab, anti-CD20 monoclonal antibody

  4. 30 CFR 77.209 - Surge and storage piles. (United States)


    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Surge and storage piles. 77.209 Section 77.209... Installations § 77.209 Surge and storage piles. No person shall be permitted to walk or stand immediately above a reclaiming area or in any other area at or near a surge or storage pile where the...

  5. Numerical Evaluation of Storm Surge Indices for Public Advisory Purposes (United States)

    Bass, B.; Bedient, P. B.; Dawson, C.; Proft, J.


    After the devastating hurricane season of 2005, shortcomings with the Saffir-Simpson Hurricane Scale's (SSHS) ability to characterize a tropical cyclones potential to generate storm surge became widely apparent. As a result, several alternative surge indices were proposed to replace the SSHS, including Powell and Reinhold's Integrated Kinetic Energy (IKE) factor, Kantha's Hurricane Surge Index (HSI), and Irish and Resio's Surge Scale (SS). Of the previous, the IKE factor is the only surge index to-date that truly captures a tropical cyclones integrated intensity, size, and wind field distribution. However, since the IKE factor was proposed in 2007, an accurate assessment of this surge index has not been performed. This study provides the first quantitative evaluation of the IKEs ability to serve as a predictor of a tropical cyclones potential surge impacts as compared to other alternative surge indices. Using the tightly coupled ADvanced CIRCulation and Simulating WAves Nearshore models, the surge and wave responses of Hurricane Ike (2008) and 78 synthetic tropical cyclones were evaluated against the SSHS, IKE, HSI and SS. Results along the upper TX coast of the Gulf of Mexico demonstrate that the HSI performs best in capturing the peak surge response of a tropical cyclone, while the IKE accounting for winds greater than tropical storm intensity (IKETS) provides the most accurate estimate of a tropical cyclones regional surge impacts. These results demonstrate that the appropriate selection of a surge index ultimately depends on what information is of interest to be conveyed to the public and/or scientific community.

  6. Validation of a surge model by full scale testing

    NARCIS (Netherlands)

    Smeulers, J.P.M.; Gonzalez Díez, N.; Slot, H.J.


    Surge of turbo compressors can cause large almost step like changes in flow and pressure, which can potentially damage the compressor and any equipment that is in direct connection with the compressor. In spite of an anti-surge controller (ASC), at extreme events surge cycles may occur. In order to

  7. Numerical study of flow fluctuation attenuation performance of a surge tank

    Institute of Scientific and Technical Information of China (English)

    郭兰兰; 刘正刚; 耿介; 李东; 杜广生


    The surge tank plays an important role in ensuring the stability of a water flow standard device. To study the influence of the structure and the working conditions on the regulator performance of a surge tank, a three-dimensional model, including a surge tank, the pipeline and the water tank is built, and the VOF model in the Fluent software is used to simulate the two-phase pulsatile flow in the surge tank. The inlet flow pulsation is defined by the User Defined Functions (UDF), and the outlet flow is set to be a free jet. By calculating the flow fluctuation coefficient of the variation under different flow conditions, the influences of the pulse frequency, the initial water level height and the baffle plate structure on the flow stability are analyzed. It is shown that the surge tank has a good attenuation effect on high-frequency pulsations, there is an optimal initial water level to suppress the fluctuations, the round holes of the baffle should ensure a certain circulation area with the bore diameter small enough to have the necessary damping effect.

  8. Differentiating between benign follicular nodules and follicular neoplasms in thyroid liquid-based cytology preparations. (United States)

    Suzuki, Ayana; Hirokawa, Mitsuyoshi; Higuchi, Miyoko; Takada, Nami; Yamao, Naoki; Kuma, Seiji; Miyauchi, Akira


    The cytological morphology observed in liquid-based cytology (LBC) preparations is dissimilar to that of conventional preparations. The aim of this report is to clarify the cytological differences between benign follicular nodules (BFNs) and follicular neoplasms (FNs) in LBC preparations and identify novel diagnostic criteria for LBC preparations. A retrospective review of LBC preparations from 38 BFN and 74 FN (57 follicular adenomas and 17 follicular carcinomas) cases confirmed by histological examination was conducted. LBC samples were obtained from the washout fluid in aspiration needles, fixed with CytoRich-RED(TM) , and prepared using the SurePath(TM) method. Fibrin was observed in 43.2% of FNs and in 23.7% of BFNs. The incidences of intercellular spaces, distinct outer margin, and cytoplasmic process were significantly higher in BFNs (P < 0.01, P < 0.01, and P < 0.05, respectively). Elongated microfollicles were seen in 55.4% of FNs and 10.5% of BFNs (P < 0.01). Membranous materials encircling the outer edge of the follicles were observed only in BFN cases (5.8%). There were no significant differences between follicular adenoma and carcinoma. Intercellular spaces, distinct outer margins of the follicular clusters, cytoplasmic process, and membranous materials constitute indicators of BFN in LBC preparations. Fibrin and elongated microfollicles point to FN. We believe that these findings will improve the diagnostic accuracy of thyroid LBC preparations. Diagn. Cytopathol. 2016;44:659-664. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  9. Relationship between endogenous progesterone and follicular dynamics in lactating dairy cows with ovarian follicular cysts. (United States)

    Hatler, T B; Hayes, S H; Laranja da Fonseca, L F; Silvia, W J


    Two experiments were conducted to examine circulating concentrations of progesterone (P4) in cows with ovarian follicular cysts (OFCs) and to relate differing levels of P4 to subsequent follicular events. In experiment 1, peripheral concentrations of P4 were determined in cows diagnosed with OFCs. Nonpregnant, lactating Holstein and Jersey cows (n = 32) were diagnosed as having OFCs by rectal palpation. Ovarian follicular cysts were then examined by transrectal ultrasonography to confirm the presence of OFCs (follicle diameter, >/=17 mm; absence of luteal tissue). At confirmation, a blood sample was collected for quantification of P4. The concentration of P4 at confirmation was classified as low (/=10 mm) that formed in the presence of an OFC was determined and related to circulating concentrations of P4 during follicular development. Follicles (n = 59) that formed in the presence of an OFC ovulated (n = 19), formed a cyst (n = 30), or underwent normal growth and regression (NGR; n = 10). Endogenous P4 in the 7-day period during follicular development was classified as low (if P4 dropped to day or longer), intermediate (if P4 averaged between 0.1 and 1.0 ng/ml and never dropped to 1.0 ng/ml and never dropped to <0.1 ng/ml). In the presence of intermediate P4, 75% of observed follicles formed cysts, compared with 10% that ovulated and 15% that experienced NGR. In the presence of low P4, 53%, 41%, and 6% of follicles ovulated, formed a follicular cyst, or experienced NGR, respectively. Thus, an association between intermediate P4 and the formation of OFCs was established.

  10. Winter speed-up of quiescent surge-type glaciers in Yukon, Canada (United States)

    Abe, T.; Furuya, M.


    Glacier surges often initiate in winter, but the mechanism remains unclear in contrast to the well-known summer speed-up at normal glaciers. To better understand the mechanism, we used radar images to examine spatial-temporal changes in the ice velocity of surge-type glaciers near the border of Alaska and the Yukon, focusing on their quiescent phase. We found significant accelerations in the upstream region from autumn to winter, regardless of surging episodes. Moreover, the winter speed-up propagated from upstream to downstream. Given the absence of surface meltwater input in winter, we suggest the presence of water storage near the base that does not directly connect to the surface, yet can promote basal sliding through increased water pressure. Our findings have implications for the modelling of glacial hydrology in winter, which may help us better understand glacier dynamics.

  11. Guiding Surge Reduction Strategies via Characterization of Coastal Surge Propagation and Internal Surge Generation within a Complex Bay/Estuary System, Galveston Bay, TX (United States)

    Bass, B.; Torres, J.; Irza, N.; Bedient, P. B.; Dawson, C.; Proft, J.


    In this study, Hurricane Ike (2008) and a suite of synthetic storms are simulated in order to evaluate how different hurricane landfalls, wind intensities, and radius to maximum winds influence the surge response in complex semi-enclosed bays such as Galveston Bay, located along the Texas Gulf Coast. The Advanced CIRCulation and Simulating Waves Nearshore (ADCIRC+SWAN) models are employed to quantify surge in terms of its relative coastal contributions that propagate across barrier islands and tidal inlets and subsequently into Galveston Bay, the surge generated locally within the Bay itself, and the interaction between these coastal and local components of surge. Results from this research will further the current understanding of surge interactions in bay systems and guide coastal engineering surge reduction projects that need to consider multiple lines of defense to protect complex bay/estuary systems such as Galveston Bay, TX.

  12. Hypergravity induced prolactin surge in female rats (United States)

    Megory, E.; Oyama, J.


    Acute initial exposure to hypergravity (HG) was previously found to induce prolonged diestrous in rats, which was followed by return to normal estrous cycling upon more prolonged exposure to continuous HG. Bromergocryptine was found to prevent this prolonged diestrous. In this study it is found that in female rats 20 h of 3.14 G exposure (D-1 1200 h until D-2 0800 h) can induce prolactin surge at D-2 1600 h. Shorter exposure time (8 h), or exposure during a different part of the estrous cycle (19 h: from D-1 0700 h until D-2 0200 h) could not elicit this prolactin surge. Similar exposure of male rats of HG did not alter significantly their prolactin levels. It is possible that the hypothalamus of male and female rats responds differently to stimulation by HG.

  13. Remote-sensing-based analysis of the 1996 surge of Northern Inylchek Glacier, central Tien Shan, Kyrgyzstan (United States)

    Häusler, Hermann; Ng, Felix; Kopecny, Alexander; Leber, Diethard


    The evolution of Northern Inylchek Glacier and its proglacial lake - Upper Lake Merzbacher - during its 1996 surge and the surrounding decades is analyzed with remote sensing imagery. Overall retreat of the glacier from 1943 to 1996 enlarged the lake to 4 km long and ≈ 100 m deep. The surge in 1996 initiated between 12 September and 7 October and advanced the glacier by 3.7 km to override most of Upper Lake Merzbacher. The surge phase probably ended in December 1996 and involved mean flow velocities across the lower trunk of the glacier that reached 50 m d- 1 over a 32-day period. Water displaced by the surge from Upper Lake Merzbacher, totalling 1.5 × 108 m3 in volume, accelerated filling of Lower Lake Merzbacher downvalley and helped trigger this marginal ice-dammed lake to outburst in a jökulhlaup around late November/early December. The characteristics and duration of the surge render it as similar to temperate glacier surges elsewhere. It may have been facilitated by low basal friction caused by water-saturated sediments in the upper lake bed. Furthermore, bathymetric measurements show that the surge evacuated much sediment into the upper lake, causing its depth to reduce from 20 to 30 m in 1996 to 8 m by 2005 and 2 m by 2011; the corresponding deposition rates imply glacier-catchment specific mean sediment yields of 1.4 to 3.4 × 103 Mg km- 2 a- 1 in the years after the surge. Our study documents novel interactions within a cascade system of glaciers and lakes that exhibits surging and outburst-flood behavior.

  14. Probabilistic Storm Surge Hazard Assessment in Martinique (United States)

    Krien, Yann; Dudon, Bernard; Sansorgne, Eliot; Roger, Jean; Zahibo, Narcisse; Roquelaure, Stevie


    Located at the center of the Lesser Antilles, Martinique is under the threat of hurricanes formed over the warm tropical waters of the Atlantic Ocean and Caribbean Sea. These events can be extremely costly in terms of human, property, and economic losses. Storm surge hazard studies are hence required to provide guidance to emergency managers and decision-makers. A few studies have been conducted so far in the French Lesser Antilles, but they mainly rely on scarce historical data of extreme sea levels or numerical models with coarse resolutions. Recent progress in statistical techniques for generating large number of synthetic hurricanes as well as availability of high-resolution topographic and bathymetric data (LIDAR) and improved numerical models enables us today to conduct storm surge hazard assessment studies with much more accuracy. Here we present a methodology to assess cyclonic surge hazard in Martinique both at regional and local scales. We first simulate the storm surges that would be induced by a large set of potential events generated by the statistical/deterministic models of Emanuel et al. [2006]. We use the ADCIRC-SWAN coupled models (Dietrich et al 2012) to simulate inundation inland with grid resolutions of up to 50-100m in the coastal area for the whole island.These models are validated against observations during past events such as hurricane Dean in 2007. The outputs can then be used in some specific sites to force higher resolution models for crisis management and local risk assessment studies. This work is supported by the INTERREG IV « Caribbean » program TSUNAHOULE.

  15. Treatment strategies for nodal and gastrointestinal follicular lymphoma:Current status and future development

    Institute of Scientific and Technical Information of China (English)

    Takuya; Watanabe


    In recent years,therapies for follicular lymphoma (FL) have steadily improved.A series of phase Ⅲ trials comparing the effect of rituximab with chemotherapy vs chemotherapy alone in treating FL have indicated significant improvements in progression-free survival (PFS) and overall survival.Recent studies have found that prolonged response durations and PFS were obtained with maintenance therapy using rituximab or interferon after completion of first line therapy.For patients with relapsed or refractory FL,ph...

  16. Design and Characterization of a Centrifugal Compressor Surge Test Rig

    Directory of Open Access Journals (Sweden)

    Kin Tien Lim


    Full Text Available A detailed description of a new centrifugal compressor surge test rig is presented. The objective of the design and development of the rig is to study the surge phenomenon in centrifugal compression systems and to investigate a novel method of surge control by active magnetic bearing servo actuation of the impeller axial tip clearance. In this paper, we focus on the design, initial setup, and testing of the rig. The latter two include the commissioning of the rig and the experimental characterization of the compressor performance. The behavior of the compressor during surge is analyzed by driving the experimental setup into surge. Two fundamental frequencies, 21 Hz and 7 Hz, connected to the surge oscillation in the test rig are identified, and the observed instability is categorized according to the intensity of pressure fluctuations. Based on the test results, the excited pressure waves are clearly the result of surge and not stall. Also, they exhibit the characteristics of mild and classic surge instead of deep surge. Finally, the change in the compressor performance due to variation in the impeller tip clearance is experimentally examined, and the results support the potential of the tip clearance modulation for the control of compressor surge. This is the first such demonstration of the feasibility of surge control of a compressor using active magnetic bearings.

  17. Hormonal composition of follicular fluid from abnormal follicular structures in mares. (United States)

    Beltman, M E; Walsh, S W; Canty, M J; Duffy, P; Crowe, M A


    The objective was to characterise the hormonal composition of follicular fluid from mares with distinct anovulatory-cystic follicles. Follicular fluid was aspirated from six mares that presented with cystic follicles and from pre-ovulatory follicles of five normal mares (controls). Differences in progesterone, oestradiol, testosterone, IGF-I and IGF binding were analysed using Fisher's exact test. There were greater (P < 0.03) follicular fluid oestradiol concentrations in normal follicles and the testosterone concentration of the cystic fluid was greater (P < 0.05) than that of the normal fluid. There also was a greater (P < 0.03) percentage of IGF-I binding and lower (P < 0.02) IGF-I concentrations in the fluid collected from the cystic structures compared with the fluid from normal follicles. Despite the limited number of animals, the fact that fluid aspirated from cystic follicles had higher testosterone and lower oestradiol concentrations could be of diagnostic value when a practitioner wants to distinguish between a cystic and non-cystic persistent follicle. The research reported here also indicates a likely role for the IGF system in the pathogenesis of the development and maintenance of anovulatory follicular structures in mare ovaries.

  18. Estado nutricional e consumo alimentar de mulheres jovens na fase lútea e folicular do ciclo menstrual Nutritional status and food consumption of young women in the luteal and follicular phases of the menstrual cycle

    Directory of Open Access Journals (Sweden)

    Larissa Almenara Silva dos Santos


    Full Text Available OBJETIVO: Avaliar o estado nutricional e a ingestão alimentar de mulheres adultas sadias durante o ciclo menstrual. MÉTODOS: Quarenta e cinco voluntárias foram acompanhadas durante três meses. A avaliação do estado nutricional foi baseada no índice de massa corporal, porcentagem de gordura e água corporal. Foram aplicados seis registros alimentares para análise da ingestão dos grupos de alimentos, usando como base o guia alimentar da pirâmide. Para a observação do sintoma "desejos alimentares", foram utilizados três "mapas de sintomas diários". RESULTADOS: Os valores médios de índice de massa corporal e de porcentagem de gordura corporal apresentaram-se normais em ambas as fases, entretanto foi observado maior percentual de mulheres com água corporal acima do padrão na fase lútea (77%. O consumo de alimentos do grupo complementar foi maior na fase lútea. Todos os outros grupos de alimentos, com exceção do grupo de carnes, apresentaram consumo inferior às recomendações, em ambas as fases. A intensidade do sintoma "desejos alimentares" foi leve durante o ciclo menstrual, não sendo observada diferença significativa entre as fases. O sintoma "desejos alimentares" associou-se positivamente com o aumento da ingestão do grupo complementar na fase lútea. CONCLUSÃO: O ciclo menstrual influencia o comportamento alimentar e leva à retenção hídrica, na fase lútea, em mulheres adultas sadias.OBJECTIVE: This study assessed the nutritional status and food intake of healthy young women during the menstrual cycle. METHODS: Forty-five volunteers were followed for three months. Their nutritional status was determined by body mass index, body fat and total body water. Six food recall instruments were used to evaluate food group intake according to the food guide pyramid. Food cravings were detected by three daily symptom charts. RESULTS: The mean body mass index and body fat were normal in both phases; however, there was a higher

  19. The eSurge-Venice project: altimeter and scatterometer satellite data to improve the storm surge forecasting in the city of Venice (United States)

    Zecchetto, Stefano; De Biasio, Francesco; Umgiesser, Georg; Bajo, Marco; Vignudelli, Stefano; Papa, Alvise; Donlon, Craig; Bellafiore, Debora


    On the framework of the Data User Element (DUE) program, the European Space Agency is funding a project to use altimeter Total Water Level Envelope (TWLE) and scatterometer wind data to improve the storm surge forecasting in the Adriatic Sea and in the city of Venice. The project will: a) Select a number of Storm Surge Events occurred in the Venice lagoon in the period 1999-present day b) Provide the available satellite Earth Observation (EO) data related to the Storm Surge Events, mainly satellite winds and altimeter data, as well as all the available in-situ data and model forecasts c) Provide a demonstration Near Real Time service of EO data products and services in support of operational and experimental forecasting and warning services d) Run a number of re-analysis cases, both for historical and contemporary storm surge events, to demonstrate the usefulness of EO data The re-analysis experiments, based on hindcasts performed by the finite element 2-D oceanographic model SHYFEM (, will 1. use different forcing wind fields (calibrated and not calibrated with satellite wind data) 2. use Storm Surge Model initial conditions determined from altimeter TWLE data. The experience gained working with scatterometer and Numerical Weather Prediction (NWP) winds in the Adriatic Sea tells us that the bias NWP-Scatt wind is negative and spatially and temporally not uniform. In particular, a well established point is that the bias is higher close to coasts then offshore. Therefore, NWP wind speed calibration will be carried out on each single grid point in the Adriatic Sea domain over the period of a Storm Surge Event, taking into account of existing published methods. Point #2 considers two different methodologies to be used in re-analysis tests. One is based on the use of the TWLE values from altimeter data in the Storm Surge Model (SSM), applying data assimilation methodologies and trying to optimize the initial conditions of the

  20. Paraplegia as initial presentation of follicular thyroid carcinoma. (United States)

    Haghpanah, Vahid; Abbas, Syed Imran; Mahmoodzadeh, Hossein; Shojaei, Abdolreza; Soleimani, Ali; Larijani, Bagher; Tavangar, Seyed Mohammad


    Follicular thyroid carcinoma with metastasis rarely presents with clinical picture of spinal cord compression. This report describes a 53 years old patient with follicular thyroid carcinoma who presented with paraplegia and urinary incontinence. Magnetic resonance imaging (MRI) of neck revealed a mass with destruction of C5 and extension to C6. Histopathology study demonstrated metastatic carcinoma of thyroid.

  1. Prognostic factors in papillary and follicular thyroid carcinomas

    DEFF Research Database (Denmark)

    Godballe, C; Asschenfeldt, P; Jørgensen, K E;


    carcinomas. The analyses were based on cause-specific and crude survival. In univariate analysis, age at diagnosis, tumor size, presence of distant metastases, histology (papillary contra follicular type), extrathyroidal invasion, necrosis in primary tumor, and p53 expression were significant prognostic...... prognostic indicator, which might be of value in the treatment planning in patients with papillary or follicular thyroid carcinomas....

  2. Technical Letter Report Assessment of Ultrasonic Phased Array Testing for Cast Austenitic Stainless Steel Pressurizer Surge Line Piping Welds and Thick Section Primary System Cast Piping Welds JCN N6398, Task 2A

    Energy Technology Data Exchange (ETDEWEB)

    Diaz, Aaron A.; Denslow, Kayte M.; Cinson, Anthony D.; Morra, Marino; Crawford, Susan L.; Prowant, Matthew S.; Cumblidge, Stephen E.; Anderson, Michael T.


    Research is being conducted for the NRC at PNNL to assess the effectiveness and reliability of advanced NDE methods for the inspection of LWR components. The scope of this research encompasses primary system pressure boundary materials including cast austenitic stainless steels (CASS), dissimilar metal welds (DMWs), piping with corrosion-resistant cladding, weld overlays, and far-side examinations of austenitic piping welds. A primary objective of this work is to evaluate various NDE methods to assess their ability to detect, localize, and size cracks in coarse-grained steel components. This interim technical letter report (TLR) provides a synopsis of recent investigations at PNNL aimed at evaluating the capabilities of phased-array (PA) ultrasonic testing (UT) methods as applied to the inspection of CASS welds in nuclear reactor piping. A description of progress, recent developments and interim results are provided.

  3. Climatic Controls on the Distribution of Surging Glaciers (United States)

    Sevestre, H.; Benn, D.


    Surge-type glaciers are scattered in a non-random fashion, gathered in clusters in some glaciated regions. One group of clusters forms an Arctic and Sub-Arctic 'crescent', spanning from Alaska-Yukon, through Arctic Canada, West and East Greenland, Iceland, Svalbard and Novaya Zemlya. Another cluster occurs in western High Asia, including the Karakoram Mountains. Although several studies have assessed the influence of environmental controls on surging, so far none has provided a satisfactory explanation for the geographical location of these clusters. The distribution of such glaciers undoubtedly holds the keys of a better understanding on the controls on surging behaviour. For this study, two glacier populations are considered. First, a global inventory of glacier surges has been compiled, based on published observations, field reports and remote sensing studies. This digital database is structured in three tables, respectively providing information on the location and geometry of each surge-type glacier, surge dates and magnitude, and methodology employed at the time of observation. This global dataset is compared to the population of "non-surge-type glaciers" based on the Randolph Glacier Inventory version 2.0 excluding the inventoried surging glaciers. In both populations, glaciers are classified depending on their geometry and thermal regime. Downscaled climatic datasets are used to identify climatic envelopes associated with clusters of surging glaciers. We identified which environments are most prone to be associated to glacier surging, and examined the influence of these parameters on the surge cycle duration and character. These results emphasize the importance of external controls on surging (as against individual surges), and promote the need to study this behaviour in the frame of an energy-balance budget.

  4. Natural influence of season on follicular, luteal, and endocrinological turnover in Indian crossbred cows. (United States)

    Satheshkumar, S; Brindha, K; Roy, A; Devanathan, T G; Kathiresan, D; Kumanan, K


    The study was aimed at investigating the effect of seasonal changes on follicular and luteal dynamics in vivo in normally cycling crossbred cows during summer and winter months of the year. Six healthy regularly cycling Jersey crossbred nonlactating pluriparous cows were used for the study. Follicular and luteal developmental pattern was studied every other day throughout the estrous cycle by scanning the ovaries during two periods of a year viz., hot season (April to June; n = 16) and cold season (December to February; n = 12). Plasma progesterone (P4) concentrations were measured on Days 0 (estrus), 6, and 12 of the estrous cycle. Among the 12 cycles studied during the cold season, 11 (91.7%) had three waves and one had two waves. Of 16 cycles studied during the hot season, eight (50%) had two waves, four (25%) had three waves, and the remaining four cycles had single (n = 2) and four waves (n = 2). High P4 concentrations during the midcycle would have suppressed the dominant follicle of the second follicular wave and induced the emergence of the third wave during the cold season. The first follicular wave (wave I) of the cycle emerged much earlier (Day 0.5 ± 0.3) during the cold season than that in the hot season (Day 1.7 ± 0.4). The ovulatory wave emerged significantly earlier during the hot season (Day 11.5 ± 1.3) than in the cold season (Day 14.8 ± 0.4), and hence, the growth phase of ovulatory follicle significantly increased during the former season (11.0 ± 1.4 days) than the latter (5.8 ± 0.2 days). The ovulatory follicle attained a significantly larger diameter (12.8 ± 0.8 mm) to express the estrus during the hot season when compared to the cold season (11.3 ± 0.4 mm), which might be indicative of alterations in steroidogenic activity within the follicular microenvironment. During the midphase of the cycle, a period critical for embryonic sustenance, the P4 level was significantly reduced in the hot months indicating suppression of luteal activity

  5. [Follicular conjunctivitis due to Chlamydia trachomatis]. (United States)

    Basualdo, J A; Huarte, L; Bautista, E; Niedfeld, G; Alfonso, G; Rosso, N; Geronés, M; Galeppi, I


    During two years (1997-1999) an investigation of possible infections of chlamydial etiology in outpatients with follicular conjunctivitis was carried out, through the use of specific assays. Fifty-seven selected patients with presumptive inclusion conjunctivitis were diagnosed by means of ophthalmoscopic examination and bilateral tarsal-conjunctiva swabbing for microorganisms. The possible presence of Chlamydia trachomatis was tested by immunofluorescence microscopy and isolation in cell culture of McCoy line. Of the 57 conjunctivitis patients screened, 37 (65%) proved to be positive by cell culture (CC) and 27 (47%) by direct immunofluorescence (IFD). A good agreement between the two assays was observed, where the CC was more sensitive than IFD. Of these 37 patients with chlamydial conjunctivitis, 23 (62%) were women, with over one-third of them ranging in age from 45 to 65 years. Their clinical records revealed an evolution period of 1 to 12 months. Eighteen (78%) of these women reported previous genital pathology, while 4 (29%) of the 14 men had a history of urethritis by Chlamydia trachomatis. A high frequency of follicular conjunctivitis by Chlamydia (65%) in the screened patients was observed, without any evidence of urogenital signs and symptoms at the moment of the study.

  6. Invasive follicular thyroid carcinoma infiltrating trachea

    Directory of Open Access Journals (Sweden)

    Filipović Aleksandar


    Full Text Available Introduction. Although follicular thyroid carcinoma is a rare malignant tumor, up to 20% of the patients are threatened by potential complications resulting from infiltrating tumor growth into surrounding tissues. Case report. A 66- year-old female came to hospital with the presence of a growing thyroid nodule of the left lobe. Ultrasonic examination showed a 8 cm hypoechoic nodule in the left lobe. Thyroid scintigraphy showed a cold nodule. CT scan and tracheoscopy showed tracheal infiltration without tracheal obstruction. An extended total thyroidectomy was done, with the left jugular vein, strap muscles and tracheal 2 cm long circular resection. The pathologist confirmed invasive follicular thyroid cancer. After the surgery the patient was treated with radioiodine therapy and permanent TSH suppressive therapy. The patient was followed with measurements of the thyroid hormone and serum thyroglobulin level every six months, as well as the further tests (chest xray, ultrasound of the neck and a whole body scintigraphy were done. After more than three years the patient had no evidence of the recurrent disease. Conclusion. Radical resection of the tracheal infiltrating thyroid cancer with circular tracheal resection and terminoterminal anastomosis followed by radioiodine therapy should be considered the treatment of choice.


    Directory of Open Access Journals (Sweden)

    Alessia Castellino


    Full Text Available Follicular lymphoma (FL is the most common indolent non-Hodgkin lymphoma, typically affected mature adults and elderly, with a median age at diagnosis of 65 years. The natural history of FL appears to have been favorably impacted by the introduction of Rituximab. Randomized clinical trials have demonstrated that the addition of rituximab to standard chemotherapy induction has improved the overall survival and new strategies of chemo-immunotherapy, such as Bendamustine combined with Rituximab, showed optimal results on response and lower hematological toxicity, becoming one of the standard treatments, particularly in elderly. Moreover maintenance therapy with Rituximab demonstrated improvement of progression-free survival. Despite these exciting results, FL is still an incurable disease. It remains a critical unmet clinical need finding new prognostic factors to better identify poor outcome patients, to reduce the risk of transformation and to explore new treatment strategies, especially for patients not candidate to intensive chemotherapy regimens, such as elderly patients. Some progresses were already done with novel agents, but larger and more validated studies are needed. Elderly patients are the larger portion of patients with FL and represent a subgroup with higher treatment difficulties, because of comorbidities and smaller spectrum for treatment choice. Further studies, focused on elderly follicular lymphoma patients, with their peculiar characteristics, are needed in order to define the best tailored treatment at diagnosis and at the time of relapse in this setting.

  8. Atlantic hurricane surge response to geoengineering

    Energy Technology Data Exchange (ETDEWEB)

    Moore, John C.; Grinsted, Aslak; Guo, Xiaoran; Yu, Xiaoyong; Jevrejeva, Svetlana; Rinke, Annette; Cui, Xuefeng; Kravitz, Ben; Lenton, Andrew; Watanabe, Shingo; Ji, Duoying


    Devastating Atlantic hurricanes are relatively rare events. However their intensity and frequency in a warming world may rapidly increase by a factor of 2-7 for each degree of increase in mean global temperature. Geoengineering by stratospheric sulphate aerosol injection cools the tropics relative to the polar regions, including the hurricane main development region in the Atlantic, suggesting that geoengineering may be an effective method of controlling hurricanes. We examine this hypothesis using 8 Earth System Model simulations of climate under the GeoMIP G3 and G4 schemes that use stratospheric aerosols to reduce the radiative forcing under the RCP4.5 scenario. Global mean temperature increases are greatly ameliorated by geoengineering, and tropical temperature increases are at most half of those in RCP4.5, but sulphate injection would have to double between 2020 and 2070 to balance RCP 4.5 to nearly 10 Tg SO2 yr-1, with consequent implications for damage to stratospheric ozone. We project changes in storm frequencies using a temperature-dependent Generalized Extreme Value statistical model calibrated by historical storm surges from 1923 and observed temperatures. The numbers of storm surge events as big as the one that caused the 2005 Katrina hurricane are reduced by about 50% compared with no geoengineering, but this is only marginally statistically significant. However, when sea level rise differences at 2070 between RCP4.5 and geoengineering are factored in to coastal flood risk, we find that expected flood levels are reduced by about 40 cm for 5 year events and perhaps halved for 50 year surges.

  9. Atlantic hurricane surge response to geoengineering. (United States)

    Moore, John C; Grinsted, Aslak; Guo, Xiaoran; Yu, Xiaoyong; Jevrejeva, Svetlana; Rinke, Annette; Cui, Xuefeng; Kravitz, Ben; Lenton, Andrew; Watanabe, Shingo; Ji, Duoying


    Devastating floods due to Atlantic hurricanes are relatively rare events. However, the frequency of the most intense storms is likely to increase with rises in sea surface temperatures. Geoengineering by stratospheric sulfate aerosol injection cools the tropics relative to the polar regions, including the hurricane Main Development Region in the Atlantic, suggesting that geoengineering may mitigate hurricanes. We examine this hypothesis using eight earth system model simulations of climate under the Geoengineering Model Intercomparison Project (GeoMIP) G3 and G4 schemes that use stratospheric aerosols to reduce the radiative forcing under the Representative Concentration Pathway (RCP) 4.5 scenario. Global mean temperature increases are greatly ameliorated by geoengineering, and tropical temperature increases are at most half of those temperature increases in the RCP4.5. However, sulfate injection would have to double (to nearly 10 teragrams of SO2 per year) between 2020 and 2070 to balance the RCP4.5, approximately the equivalent of a 1991 Pinatubo eruption every 2 y, with consequent implications for stratospheric ozone. We project changes in storm frequencies using a temperature-dependent generalized extreme value statistical model calibrated by historical storm surges and observed temperatures since 1923. The number of storm surge events as big as the one caused by the 2005 Katrina hurricane are reduced by about 50% compared with no geoengineering, but this reduction is only marginally statistically significant. Nevertheless, when sea level rise differences in 2070 between the RCP4.5 and geoengineering are factored into coastal flood risk, we find that expected flood levels are reduced by about 40 cm for 5-y events and about halved for 50-y surges.

  10. Southeastern Regional Pediatric Disaster Surge Network: a public health partnership. (United States)

    Ginter, Peter M; Rucks, Andrew C; Duncan, W Jack; Wingate, Martha S; Beeman, S Kenn; Reeves, Jane; West, Maury A


    In the event of a natural or man-made disaster involving large numbers of children, resources in the Southeastern U.S. are extremely limited. This article chronicles the efforts of the Alabama Department of Public Health, the Mississippi State Department of Health, and the South Central Center for Public Health Preparedness in conjunction with more than 40 organizations to develop a voluntary network of health-care providers, public health departments, volunteers, and emergency responders from Alabama, Florida, Louisiana, Mississippi, and Tennessee. The purpose of the Southeastern Regional Pediatric Disaster Surge Network (the Network) is to improve the pediatric preparedness response strategies of public health, emergency response, and pediatric providers in the event of large-scale emergencies or disasters that overwhelm local or state pediatric resources. The planning and development of the Network is proceeding through three general phases--information sharing, mutual goal setting and collective action, and long-term formal linkages. In Phase 1, critical planning tasks to be undertaken in the development of the Network were identified. In Phase 2, the agencies developed a draft operational handbook that served as the basis for a formal memorandum of understanding. In Phase 3, participants will engage in exercises and evaluations that will further identify and work out logistical and operational details.

  11. Sedimentological features of the surge emitted during the August, 2006 pyroclastic eruption at Tungurahua volcano (Ecuador) (United States)

    Douillet, G.; Goldstein, F.; Lavallee, Y.; Hanson, J. B.; Kueppers, U.; Robin, C.; Ramon, P.


    Tungurahua volcano, Ecuador, is a stratovolcano, which began a new eruptive phase in 1999. Notable pyroclastic Density Currents (PDC) were generated in July (VEI 2) and August (VEI 3) 2006 and covered its N and W flanks. PDCs and associated lahars represent a major hazard for 20,000 inhabitants and an hydrological dam. The volcano has been monitored by the Instituto Geofisico of the Escuela Politécnica Nacional of Quito, since 1988. Field work carried out in 2009 provide information on the behavior of the fine-grained fraction of the PDC (i.e., surge) during transport and deposition. We mapped out the sedimentological characteristics of the deposits and distinguished three depositional environments: 1- The core of the deposit, up to several m in thickness, is confined to valleys and consists of poorly-sorted lapilli scoria and blocks (cm to m scale) and a small fraction of ash matrix. Ongoing analysis of the ash matrix will help to understand the link between the main PDC and the associated surge. 2- On ridges and outer margins of valleys, the deposits total a thickness of 10s to 100s cm and consist of fine- to coarse-grain ashes organized in cm-scale beds. Horizontal to cross bed laminations with 10-cm long wavelength prevail. They are typical of deposition under sustained high-energy current, which we associate with the flow of a surge. 3- In the distal part of surge deposits, we observe fine grained surge deposits with a thickness up to ca. 5 m. The characteristic structures are curved crested dunes, 10s of cm high and up to 10s of m long, with dip angles ranging from 15 to 35° and a strongly asymmetric shape. The steepest side tends to be the upslope face. Dunes show mainly a climbing structure, with beds cm in thickness, but some are more complicated, containing cut and fill structures, interpreted as late-stage pulses of energetic turbulence. No displacement dunes were observed in this area. Using the flow direction given by 100s of dunes, we provide

  12. Electrothermal model for complete metal-oxide surge arresters

    Energy Technology Data Exchange (ETDEWEB)

    Costa, E. Guedes da; Naidu, S.R. [UFPB, Dept. of Electrical Engineering, Campina Grande, PB (Brazil); Lima, A. Guedes de [CEFET-PB, Dept. of Mechanical Engineering, Joao Pessoa, PB (Brazil)


    A computational, electrothermal model for a complete metal-oxide surge arrester based on the implicit form of the finite-differences method is presented. The model is used to calculate the cooling curve after the application of overvoltages and the temperature variations during standard test. The model has been checked against experiments carried out on a test section and a complete surge arrester and the behaviour of a hypothetical surge arrester during standard tests simulated. (Author)

  13. Design and Characterization of a Centrifugal Compressor Surge Test Rig



    A detailed description of a new centrifugal compressor surge test rig is presented. The objective of the design and development of the rig is to study the surge phenomenon in centrifugal compression systems and to investigate a novel method of surge control by active magnetic bearing servo actuation of the impeller axial tip clearance. In this paper, we focus on the design, initial setup, and testing of the rig. The latter two include the commissioning of the rig and the experimental characte...

  14. Simplified Storm Surge Simulations Using Bernstein Polynomials (United States)

    Beisiegel, Nicole; Behrens, Jörn


    Storm surge simulations are vital for forecasting, hazard assessment and eventually improving our understanding of Earth system processes. Discontinuous Galerkin (DG) methods have recently been explored in that context, because they are locally mass-conservative and in combination with suitable robust nodal filtering techniques (slope limiters) positivity-preserving and well-balanced for the still water state at rest. These filters manipulate interpolation point values in every time step in order to retain the desirable properties of the scheme. In particular, DG methods are able to represent prognostic variables such as the fluid height at high-order accuracy inside each element (triangle). For simulations that include wetting and drying, however, the high-order accuracy will destabilize the numerical model because point values on quadrature points may become negative during the computation if they do not coincide with interpolation points. This is why the model that we are presenting utilizes Bernstein polynomials as basis functions to model the wetting and drying. This has the advantage that negative pointvalues away from interpolation points are prevented, the model is stabilized and no additional time step restriction is introduced. Numerical tests show that the model is capable of simulating simplified storm surges. Furthermore, a comparison of model results with third-order Bernstein polynomials with results using traditional nodal Lagrange polynomials reveals an improvement in numerical convergence.

  15. Hospital bioterrorism planning and burn surge. (United States)

    Kearns, Randy D; Myers, Brent; Cairns, Charles B; Rich, Preston B; Hultman, C Scott; Charles, Anthony G; Jones, Samuel W; Schmits, Grace L; Skarote, Mary Beth; Holmes, James H; Cairns, Bruce A


    On the morning of June 9, 2009, an explosion occurred at a manufacturing plant in Garner, North Carolina. By the end of the day, 68 injured patients had been evaluated at the 3 Level I trauma centers and 3 community hospitals in the Raleigh/Durham metro area (3 people who were buried in the structural collapse died at the scene). Approximately 300 employees were present at the time of the explosion, when natural gas being vented during the repair of a hot water heater ignited. The concussion from the explosion led to structural failure in multiple locations and breached additional natural gas, electrical, and ammonia lines that ran overhead in the 1-story concrete industrial plant. Intent is the major difference between this type of accident and a terrorist using an incendiary device to terrorize a targeted population. But while this disaster lacked intent, the response, rescue, and outcomes were improved as a result of bioterrorism preparedness. This article discusses how bioterrorism hospital preparedness planning, with an all-hazards approach, became the basis for coordinated burn surge disaster preparedness. This real-world disaster challenged a variety of systems, hospitals, and healthcare providers to work efficiently and effectively to manage multiple survivors. Burn-injured patients served as a focus for this work. We describe the response, rescue, and resuscitation provided by first responders and first receivers as well as efforts made to develop burn care capabilities and surge capacity.

  16. Tide and skew surge independence: New insights for flood risk (United States)

    Williams, Joanne; Horsburgh, Kevin J.; Williams, Jane A.; Proctor, Robert N. F.


    Storm surges are a significant hazard to coastal communities around the world, putting lives at risk and costing billions of dollars in damage. Understanding how storm surges and high tides interact is crucial for estimating extreme water levels so that we can protect coastal communities. We demonstrate that in a tidal regime the best measure of a storm surge is the skew surge, the difference between the observed and predicted high water within a tidal cycle. Based on tide gauge records spanning decades from the UK, U.S., Netherlands, and Ireland we show that the magnitude of high water exerts no influence on the size of the most extreme skew surges. This is the first systematic proof that any storm surge can occur on any tide, which is essential for understanding worst-case scenarios. The lack of surge generation dependency on water depth emphasizes the dominant natural variability of weather systems in an observation-based analysis. Weak seasonal relationships between skew surges and high waters were identified at a minority of locations where long-period changes to the tidal cycle interact with the storm season. Our results allow advances to be made in methods for estimating the joint probabilities of storm surges and tides.

  17. Auroral radio absorption and the westward travelling surge

    Energy Technology Data Exchange (ETDEWEB)

    Collis, P.N.; Korth, A.


    Measurements from a network of riometers during the passage of an auroral westward traveling surge are presented. These show that the energetic precipitation producing the radio absorption expands in an almost identical fashion to the softer precipitation associated with the visible surge; but it is delayed by about two minutes with respect to the surge. The delay is interpreted as a hardening of the precipitating electron spectrum as the surge goes by. Simultaneous observations of electrons at synchronous orbit are shown to support this conclusion. 24 references.

  18. Over 400 previously undocumented Svalbard surge-type glaciers identified (United States)

    Farnsworth, Wesley R.; Ingólfsson, Ólafur; Retelle, Michael; Schomacker, Anders


    Identifying glaciers that exhibit surge-type behavior is important when using evidence of ice front fluctuations as a proxy for reconstructing past climate oscillations. This study identifies previously undocumented surge-type glaciers in Svalbard, based on the presence of crevasse squeeze ridges in glacier forelands. Crevasse squeeze ridges are landforms suggested to be unique to surging glacier land systems. Estimates vary greatly as to the actual percentage of surge-type glaciers in Svalbard, and consequently their distribution pattern is poorly understood. A detailed survey of recent (2008-2012), high-resolution aerial imagery from TopoSvalbard, provided by the Norwegian Polar Institute, allowed for a survey of all the glacier forelands in Svalbard. Before our study, 277 individual glaciers in Svalbard have been documented to exhibit surge behavior. By using crevasse squeeze ridges as indicators of surge behavior, we have identified 431 additional glaciers that have surged. We suggest that this is a modest value as the unique surge landforms were not visible in approximately one-third of the forelands with documented surge histories. Limits to the crevasse squeeze ridge technique are presented and potential controlling factors for crevasse squeeze ridge formation/preservation are discussed.

  19. On the magnitude and frequency of Karakoram Glacier surges

    Directory of Open Access Journals (Sweden)

    D. J. Quincey


    Full Text Available The return periods of Karakoram glacier surges are almost entirely unknown. Here, we present evidence of an historic surge of the Khurdopin Glacier that began in the mid-1970s and peaked in 1979. Measured surface displacements reached > 5 km yr–1, two orders of magnitude faster than during quiescence and twice as large as any previously recorded velocity in the region. The Khurdopin Glacier next surged in the late-1990s, equating to a return period of 20 yr. Surge activity in the region needs to be better understood if accurate mass balance assessments of Hindu-Kush–Karakoram–Himalaya glaciers are to be made.

  20. The Cool Surge Following Flux Emergence in a Radiation-MHD Experiment (United States)

    Nóbrega-Siverio, D.; Moreno-Insertis, F.; Martínez-Sykora, J.


    Cool and dense ejections, typically Hα surges, often appear alongside EUV or X-ray coronal jets as a result of the emergence of magnetized plasma from the solar interior. Idealized numerical experiments explain those ejections as being indirectly associated with the magnetic reconnection taking place between the emerging and preexisting systems. However, those experiments miss basic elements that can importantly affect the surge phenomenon. In this paper we study the cool surges using a realistic treatment of the radiation transfer and material plasma properties. To that end, the Bifrost code is used, which has advanced modules for the equation of state of the plasma, photospheric and chromospheric radiation transfer, heat conduction, and optically thin radiative cooling. We carry out a 2.5D experiment of the emergence of magnetized plasma through (meso) granular convection cells and the low atmosphere to the corona. Through detailed Lagrange tracing we study the formation and evolution of the cool ejection and, in particular, the role of the entropy sources; this allows us to discern families of evolutionary patterns for the plasma elements. In the launch phase, many elements suffer accelerations well in excess of gravity; when nearing the apex of their individual trajectories, instead, the plasma elements follow quasi-parabolic trajectories with accelerations close to {g}⊙ . We show how the formation of the cool ejection is mediated by a wedge-like structure composed of two shocks, one of which leads to the detachment of the surge from the original emerged plasma dome.

  1. FDG-PET in Follicular Lymphoma Management

    Directory of Open Access Journals (Sweden)

    C. Bodet-Milin


    Full Text Available 18-Fluoro-deoxyglucose positron emission tomography/computerised tomography (FDG PET/CT is commonly used in the management of patients with lymphomas and is recommended for both initial staging and response assessment after treatment in patients with diffuse large B-cell lymphoma and Hodgkin lymphoma. Despite the FDG avidity of follicular lymphoma (FL, FDG PET/CT is not yet applied in standard clinical practice for patients with FL. However, FDG PET/CT is more accurate than conventional imaging for initial staging, often prompting significant management change, and allows noninvasive characterization to guide assessment of high-grade transformation. For restaging, FDG PET/CT assists in distinguishing between scar tissue and viable tumors in residual masses and a positive PET after induction treatment would seem to predict a shorter progression-free survival.

  2. Age-dependent role of steroids in the regulation of growth of the hen follicular wall

    Directory of Open Access Journals (Sweden)

    Lebedev Vladimir A


    Full Text Available Abstract Background The ovaries are the primary targets of senescence effects in mammalian and avian species. In the present study, relationships between reproductive aging, sex steroids and the growth pattern of the pre-ovulatory follicle wall were investigated using young hens with long clutch (YLC, old hens with long clutch (OLC, old hens with short clutch (OSC, and old hens with interrupted long clutch (OILC. Methods Experiment 1: Hens were sacrificed 1.5 and 14.5 h after ovulation. Experiment 2: YLC and OILC hens were sacrificed 3.5 h after treatments with LH and/or aminoglutethimide (AG, an inhibitor of steroid synthesis. Volumes of pre-ovulatory follicles (F1-F5 and plasma concentrations of ovarian steroids were determined. Experiment 3: Granulosa and theca cells from F3 follicles of OSC and/or YLC hens were exposed in vitro to estradiol-17beta (E2, testosterone (T and LH and the proliferative activity of the cells was examined using CellTiter 96 Aqueous One Solution Assay. Results In YLC and OLC groups, the total volume of F1-F5 follicles rose between 1.5 and 14.5 h after ovulation (P 2 (P 2 and the follicular volume (P 2 (r = -0.54, P 2 enhanced proliferation of granulosa cells from YLC and OSC groups. The proliferative activity of granulosa and theca cells of YLC hens depended on the interaction between T and LH (P Conclusions These data indicate for the first time that the growth pattern of pre-ovulatory follicles during the ovulatory cycle changes in the course of reproductive aging. E2 seems to play a dual role in this adjustment; it stimulates the growth of the follicular wall in reproductive aged hens, whereas it may inhibit this process in young birds. T and LH are apparently involved in the growth regulation during the pre-ovulatory surge in young hens.

  3. Follicular Dendritic Cell Sarcoma of the Abdomen: the Imaging Findings

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Tae Wook; Lee, Soon Jin; Song, Hye Jong [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)


    Follicular dendritic cell sarcoma is a rare neoplasm that originates from follicular dendritic cells in lymphoid follicles. This disease usually involves the lymph nodes, and especially the head and neck area. Rarely, extranodal sites may be affected, including tonsil, the oral cavity, liver, spleen and the gastrointestinal tract. We report here on the imaging findings of follicular dendritic cell sarcoma of the abdomen that involved the retroperitoneal lymph nodes and colon. It shows as a well-defined, enhancing homogenous mass with internal necrosis and regional lymphadenopathy.

  4. Follicular unit extraction as a therapeutic option for Vitiligo

    Directory of Open Access Journals (Sweden)

    S Sacchidanand


    Full Text Available Follicular unit extraction (FUE is a surgical procedure, which can be used to transplant follicular units into vitiliginous areas. Such follicular unit transplant has been recently used to repigment stable vitiligo patches. FUE was done for a 12-year-old female with a stable vitiligo patch with leukotrichia on the eyebrow. Repigmentation was noted in 6 weeks and complete pigmentation seen at 12 weeks. Leukotrichia resolved over a period of 6 months. No recurrence was noted at the end of 6 months follow-up with excellent colour match. This case is presented to highlight the simplicity, safety and effectiveness of FUE in stable vitiligo patches with leukotrichia.

  5. Modelo de Transformador de Distribución Trifásico para Estudios de Máximos de Tensión (Peaks Ocasionados por Descargas Atmosféricas Model of a Three-Phase Transformer for Studies of Voltage Surges (Peaks due to Lighting Discharges

    Directory of Open Access Journals (Sweden)

    A.G Kanashiro


    Full Text Available Este trabajo se presenta una metodología para modelar transformadores de distribución trifásico para el estudio de los máximos (peaks de tensión transferidos al secundario, en el caso de descargas atmosféricas directas o indirectas. La validación del modelo fue realizada a través de comparaciones entre simulaciones computacionales y resultados de ensayos obtenidos en el laboratorio. Los resultados mostraron que las tensiones transferidas presentadas por el modelo y por el transformador son mucho más próximas cuando se consideran los impulsos de tensión con formas de onda normalizada (1.2/40m s y típicas de tensiones inducidas. El modelo es simple y representa razonablemente bien el transformador, permitiendo el análisis de las tensiones transferidas en las redes secundarias.This paper presents a methodology for modeling three-phase distribution transformers for the analysis of the voltage surges transferred to the secondary networks when direct or indirect lightning discharges occur. The validation of the model was reached through comparisons between computer simulations and results of tests performed in the laboratory. The results showed that the voltages transferred presented by the model and by the transformer are quite similar when the voltage impulses with both standard (1.2/50m s and typical waveforms of induced voltages are considered. The model is simple and represents the transformer reasonably well, permitting the analysis of the voltages transferred in the secondary networks.

  6. Surges Initiated by Newly-emerging Satellite Magnetic Fields (United States)

    Wang, Jun-feng; Zhou, Tuan-hui; Ji, Hai-sheng


    On July 22, 2011 and in the active region NOAA 11259 there ap- peared the event of the ejection of solar atmospheric Hα surges. According to the full-disc Hα observations of the Big Bear Solar Observatory in United States, three consecutive surges at one and the same place in the north of the main spot of the active region were discovered. The trajectories of these three surges exhib- ited the figure of straight lines, and their integral configuration is like an inverted Eiffel Tower. The first two surges are quite similar, and in each of them there appeared two bright points in the northern part of the main spot. After several minutes, the surges appeared in the midst of bright points. When the bright- ness of the bright points attained the maximum value, the surges spouted out from the midst of bright points. And after reaching the maximum altitude, they quickly vanished. Before the ejection of the third surge took place, no bright points appeared. Besides, its maximal altitude is merely one half of that of the first two surges. Via a comparison with the SDO/HMI (Solar Dynamics Obser- vatory/Helioseismic and Magnetic Imager) data of radial magnetic fields, it is found that in more than one hour before the appearance of the first surge there emerged bipolar magnetic fields in the region of ejection. Besides, in several min- utes before the ejection of each Hα surge the magnetic fluxes of positive polarity diminished. Via our analysis it is found that there appeared reconnections be- tween the newly emerging satellite magnetic fields and the preexisting magnetic fields in the spot, and this caused the continuous ejections of Hα surges.

  7. Obinutuzumab: A Review in Rituximab-Refractory or -Relapsed Follicular Lymphoma. (United States)

    Dhillon, Sohita


    Obinutuzumab (Gazyva(®), Gazyvaro(®)) is a recombinant, monoclonal, humanized and glycoengineered, type II, anti-CD20, IgG1 antibody. It has recently been granted an additional indication for the treatment of patients with follicular lymphoma who relapsed after, or are refractory to, a rituximab-containing regimen. In the primary analysis of the large, phase III GADOLIN study, induction therapy with obinutuzumab plus bendamustine followed by obinutuzumab maintenance prolonged progression-free survival (PFS) to a statistically significant extent relative to induction with bendamustine monotherapy in patients with indolent non-Hodgkin's lymphoma (iNHL). The improvement in PFS was largely driven by the subgroup of patients with follicular lymphoma, who also had prolonged overall survival (OS) in a planned updated analysis. Obinutuzumab had a generally manageable tolerability profile in these patients; mild to moderate infusion-related reactions (IRRs) were the most common treatment-emergent adverse events (AEs) and neutropenia the most common grade 3 or 4 treatment-related AEs. Although additional studies and longer-term data are needed to further assess treatment benefits with obinutuzumab, current evidence indicates that obinutuzumab is a useful treatment option for patients with rituximab-refractory or -relapsed follicular lymphoma.

  8. Winter speed-up of ice flow at quiescent surge-type glaciers in Yukon, Canada (United States)

    Furuya, M.; Abe, T.


    Glacier surge exhibits order-of-magnitude faster velocity and km-scale terminus advance during its short active phase after a long quiescent period. The observations of glacier surge are still limited, and the mechanisms of glacier surge cycle remain elusive. Moreover, with the exception of several well-examined glaciers, the glacier dynamics during their quiescent periods remains even more uncertain due to the paucity of surface velocity measurement data. Here we examined spatial-temporal changes in the ice surface velocity of surge-type glaciers in the St. Elias Mountains near the border of Alaska and Yukon during the period from December 2006 to March 2011. We applied the offset-tracking (feature-tracking) technique to the L-band synthetic aperture radar (SAR) images derived from the Japanese Advanced Land Observation Satellite (ALOS). The Chitina, Anderson, Walsh, and Logan Glaciers, the major subpolar surge-type glaciers of the Chitina River valley system, could be examined with the highest temporal resolution because of the overlap of multiple satellite tracks. We have found significant upstream accelerations from fall to winter at a number of glaciers during their quiescence. Moreover, whereas the upstream propagating summer speed-up was observed, the winter speed-up propagated from upstream to downglacier. Although the winter speed-up seems to be at odds with the well-known summer speed-up, these observations are consistent with the fragmentary but well-known fact of glacier surge that often initiates in winter, suggesting that some of the mechanisms would be valid even during quiescent phases. Ice surface velocity at mountain glaciers and ice sheets typically exhibits the greatest acceleration from spring to early summer, followed by deceleration in mid-summer to fall, and is slowest in winter. These short-term velocity changes are attributed to subglacial slip associated with water pressure changes that occur because of the seasonal variability of

  9. Dynamics of a small surge-type glacier, St. Elias Mountains, Yukon Territory, Canada: characterization of basal motion using 1-D geophysical inversion


    Paoli, Laetitia


    The dynamics of a small surge-type glacier are investigated as part of a study to characterize glacier response to climate in southwest Yukon Territory, Canada. DEMs of the glacier surface and bed are constructed from surface elevation and ice thickness data. Measured surface velocities are higher than expected for a surge-type glacier in its quiescent phase over the upper 3500m of the 5km-long glacier, but much lower than typical surge velocities. Flowline basal velocities are reconstructed ...

  10. Involvement of insulin and growth hormone (GH) during follicular development in the bovine ovary. (United States)

    Shimizu, Takashi; Murayama, Chiaki; Sudo, Natsuko; Kawashima, Chiho; Tetsuka, Masa; Miyamoto, Akio


    Insulin and growth hormone (GH) play critical roles in the process of follicular development and maturation. However, the involvement of insulin receptor (IR) and GH receptor (GHR) during follicular development is not well understood. The aim of this study was to investigate the expression of IR and GHR mRNAs in the granulosa cells (GCs) and theca tissues (TCs) of the follicle at different developmental stages (preovulatory dominant follicles, POFs; estrogen-active dominant follicles, EADs; estrogen-inactive dominant follicles, EIDs; and small follicles, SFs), and second, to examine the effects of follicle-stimulating hormone (FSH) and estradiol (E2) on the expression of IR and GHR genes in cultured bovine GCs. Although the concentration of insulin in follicular fluid (FF) was constant at all developmental stages, the GH concentration in FF was significantly increased in the EAD and POF compared with the EID. IR mRNA in GCs and TCs was significantly increased in the POF compared with other follicles. Regarding GHR expression, significant increases of mRNA expression were observed in GCs of EAD compared to those of SF, EID and POF. GHR mRNA in TCs was significantly decreased in the SF compared with other follicles. In cultured GCs, FSH, but not E2, stimulated the expression of IR and GHR genes. Our results suggest that the increase in the expression of GHR may be a turning point for follicles to enter the ovulatory phase during final follicular development and that the insulin system may support the maturation of preovulatory follicles.

  11. Will oscillating wave surge converters survive tsunamis?

    Directory of Open Access Journals (Sweden)

    L. O’Brien


    Full Text Available With an increasing emphasis on renewable energy resources, wave power technology is becoming one of the realistic solutions. However, the 2011 tsunami in Japan was a harsh reminder of the ferocity of the ocean. It is known that tsunamis are nearly undetectable in the open ocean but as the wave approaches the shore its energy is compressed, creating large destructive waves. The question posed here is whether an oscillating wave surge converter (OWSC could withstand the force of an incoming tsunami. Several tools are used to provide an answer: an analytical 3D model developed within the framework of linear theory, a numerical model based on the non-linear shallow water equations and empirical formulas. Numerical results show that run-up and draw-down can be amplified under some circumstances, leading to an OWSC lying on dry ground!


    Institute of Scientific and Technical Information of China (English)

    李宏; 阮航宇


    A new type microgap surge absorber fabricated by only semiconductor technique has in it a special structure silicon chip which forms microgaps for gas discharge with electrodes, and has advantages such as small size, low cost, suitability for mass production besides the desirable characteristics that common microgap surge absorbers have. Applications of this absorber in communication facilities are discussed.

  13. Revealing glacier flow and surge dynamics from animated satellite image sequences: examples from the Karakoram (United States)

    Paul, F.


    Although animated images are very popular on the internet, they have so far found only limited use for glaciological applications. With long time series of satellite images becoming increasingly available and glaciers being well recognized for their rapid changes and variable flow dynamics, animated sequences of multiple satellite images reveal glacier dynamics in a time-lapse mode, making the otherwise slow changes of glacier movement visible and understandable to the wider public. For this study, animated image sequences were created for four regions in the central Karakoram mountain range over a 25-year time period (1990-2015) from freely available image quick-looks of orthorectified Landsat scenes. The animations play automatically in a web browser and reveal highly complex patterns of glacier flow and surge dynamics that are difficult to obtain by other methods. In contrast to other regions, surging glaciers in the Karakoram are often small (10 km2 or less), steep, debris-free, and advance for several years to decades at relatively low annual rates (about 100 m a-1). These characteristics overlap with those of non-surge-type glaciers, making a clear identification difficult. However, as in other regions, the surging glaciers in the central Karakoram also show sudden increases of flow velocity and mass waves travelling down glacier. The surges of individual glaciers are generally out of phase, indicating a limited climatic control on their dynamics. On the other hand, nearly all other glaciers in the region are either stable or slightly advancing, indicating balanced or even positive mass budgets over the past few decades.

  14. Rituximab Retreatment for Low-Tumor Burden Follicular Lymphoma (United States)

    A summary of results from a randomized clinical trial of patients with low–tumor burden follicular lymphoma that compared maintenance therapy with rituximab versus retreatment with rituximab only when there was evidence of disease progression.

  15. Switching Surge Analysis of Vacuum Circuit Breaker using EMTP

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ik Mo; Kim, Ji Hong [Hyundai Heavy Industry, Mechatronics Research Institute (Korea)


    The first objective of this study is to set up the switching surge analysis method in motor driving distribution system. The simplified model which can simulate the motor energization and circuit breaker re-ignitions, and each circuit element model is presented in this paper. The second objective is to calculate the quantity of surge over-voltage in real nuclear power station. And the surge suppressing measures are verified on the simulation basis. It is clarified that most cases are not satisfactory to meet the IEEE standard 522-1992 without using surge suppressing measures. In cases that the surge arrester are installed in distribution board at the load side of circuit breaker. The IEEE specification is fully met. (author). 6 refs., 4 figs., 3 tabs.

  16. Investigation of Surge Behavior in a Micro Centrifugal Compressor

    Institute of Scientific and Technical Information of China (English)

    Shimpei MIZUKI; Yuichiro ASAGA; Yushi ONO; Hoshio TSUJITA


    This paper reports the experimental and theoretical study of the surge occurred in prototyping an ultra micro centrifugal compressor. As the first step, the 10 times size model of an ultra micro centrifugal compressor having the 40 mm outer diameter was designed and manufactured. The detailed experimental investigations for the transient behavior of surge with several different values of B parameter were carried out. The experimental results during the surge were compared with those obtained by the non-linear lumped parameter theory in order to validate the effectiveness of the theoretical surge model for the micro centrifugal compressor. As a result, the quite different behavior of the surge appeared for the different values of B both in the experiment and in the analysis.

  17. Trends in the formation of the ovarian follicular reserve


    Denisenko, M. V.; M. A. Kurtser; L. F. Kurilo


    This review describes folliculogenesis from the formation of a primordial follicle around the oocyte during the diplotene stage of prophase of meiosis I to that of a preovulatory follicle, maturation of an oocyte, and transformation of its chromosomal nucleolus complex into the karyosphere. It briefly highlights literature disagreements on the terminology of ovarian follicular reserve and folliculogenesis. The possibilities of evaluating the ovarian follicular system are given.

  18. Trends in the formation of the ovarian follicular reserve

    Directory of Open Access Journals (Sweden)

    M. V. Denisenko


    Full Text Available This review describes folliculogenesis from the formation of a primordial follicle around the oocyte during the diplotene stage of prophase of meiosis I to that of a preovulatory follicle, maturation of an oocyte, and transformation of its chromosomal nucleolus complex into the karyosphere. It briefly highlights literature disagreements on the terminology of ovarian follicular reserve and folliculogenesis. The possibilities of evaluating the ovarian follicular system are given.

  19. Application of short-data methods on extreme surge levels (United States)

    Feng, X.


    Tropical cyclone-induced storm surges are among the most destructive natural hazards that impact the United States. Unfortunately for academic research, the available time series for extreme surge analysis are very short. The limited data introduces uncertainty and affects the accuracy of statistical analyses of extreme surge levels. This study deals with techniques applicable to data sets less than 20 years, including simulation modelling and methods based on the parameters of the parent distribution. The verified water levels from water gauges spread along the Southwest and Southeast Florida Coast, as well as the Florida Keys, are used in this study. Methods to calculate extreme storm surges are described and reviewed, including 'classical' methods based on the generalized extreme value (GEV) distribution and the generalized Pareto distribution (GPD), and approaches designed specifically to deal with short data sets. Incorporating global-warming influence, the statistical analysis reveals enhanced extreme surge magnitudes and frequencies during warm years, while reduced levels of extreme surge activity are observed in the same study domain during cold years. Furthermore, a non-stationary GEV distribution is applied to predict the extreme surge levels with warming sea surface temperatures. The non-stationary GEV distribution indicates that with 1 Celsius degree warming in sea surface temperature from the baseline climate, the 100-year return surge level in Southwest and Southeast Florida will increase by up to 40 centimeters. The considered statistical approaches for extreme surge estimation based on short data sets will be valuable to coastal stakeholders, including urban planners, emergency managers, and the hurricane and storm surge forecasting and warning system.

  20. Risk Assessment of Hurricane Storm Surge for Tampa Bay (United States)

    Lin, N.; Emanuel, K.


    Hurricane storm surge presents a major hazard for the United States and many other coastal areas around the world. Risk assessment of current and future hurricane storm surge provides the basis for risk mitigation and related decision making. This study investigates the hurricane surge risk for Tampa Bay, located on the central west coast of Florida. Although fewer storms have made landfall in the central west Florida than in regions farther west in the Gulf of Mexico and the east coast of U.S., Tampa Bay is highly vulnerable to storm surge due to its geophysical features. It is surrounded by low-lying lands, much of which may be inundated by a storm tide of 6 m. Also, edge waves trapped on the west Florida shelf can propagate along the coastline and affect the sea level outside the area of a forced storm surge; Tampa Bay may be affected by storms traversing some distance outside the Bay. Moreover, when the propagation speed of the edge wave is close to that of a storm moving parallel to the coast, resonance may occur and the water elevation in the Bay may be greatly enhanced. Therefore, Tampa Bay is vulnerable to storms with a broad spectrum of characteristics. We apply a model-based risk assessment method to carry out the investigation. To estimate the current surge risk, we apply a statistical/deterministic hurricane model to generate a set of 1500 storms for the Tampa area, under the observed current climate (represented by 1981-2000 statistics) estimated from the NCAR/NCEP reanalysis. To study the effect of climate change, we use four climate models, CNRM-CM3, ECHAM, GFDL-CM2.0, and MIROC3.2, respectively, to drive the hurricane model to generate four sets of 1500 Tampa storms under current climate conditions (represented by 1981-2000 statistics) and another four under future climate conditions of the IPCC-AR4 A1B emission scenario (represented by 2081-2100 statistics). Then, we apply two hydrodynamic models, the Advanced Circulation (ADCIRC) model and the Sea


    Directory of Open Access Journals (Sweden)

    Yu. N. Shumilov


    Full Text Available The paper shows that, in 6-35 kV mains, application of a non-linear surge arrester (SA with the maximum continuous admissible operating voltage which is 10% higher than the mains’ maximum operating voltage results in the SA protection from overheating and subsequent breakdown at nonnormable lifetime of single-phase arc faults.

  2. Evolution of surge levels inside of the Seine Bay : interactions between tide and surge levels during Johanna and Xynthia storms (United States)

    Laborie, Vanessya; Sergent, Philippe


    Within the Technical Commission for the Study and the Evaluation of Maritime Submersions in the Seine Estuary (CTeeSMES), which aim is to improve the collective knowledge on physical processes related to maritime surge levels, a numerical model of the Atlantic French Coast based on TELEMAC2D was used to study the evolution of surge levels from the ocean to the harbour area of Le Havre and evaluate the interactions between tide and surge levels in the Seine Bay. The numerical model was specifically calibrated on JOHANNA and XYNTHIA storm events, which respectively occurred in March 2008 and in February 2010. To calibrate the global signal (tide + surge levels), measurements available on 18 outputs of the Atlantic coast were used to optimize the coefficient for wind influence and for bottom friction. Maritime boundary conditions were provided by the North East Atlantic Atlas (LEGOS). Winds and pressure fields were CFSR data. Once the numerical model had been calibrated both for tide and surge levels, it has been possible to draw the evolution of surge levels from the ocean to Le Havre (quai Meunier) and then to compare the signal obtained at each point of the Seine Bay with that obtained without taking into consideration tide for each event. That also allowed to evaluate the contribution of interactions between tide and surge levels inside of the Seine Bay for Xynthia and Johanna events, but also for other events in the slice [1979-2010] and considering climate change towards 2100 with IPCC5 scenarios. It appears that instantaneous interactions between tide and surge levels nearly reach 50 % of the global surge levels and can sharply influence the evolution of surge levels in the Seine Bay depending of the moment (high tide or low water) at which the storm occurs.

  3. Exploring Risk Factors for Follicular Lymphoma

    Directory of Open Access Journals (Sweden)

    Alexander J. Ambinder


    Full Text Available Follicular lymphoma (FL is an indolent malignancy of germinal center B cells with varied incidence across racial groups and geographic regions. Improvements in the classification of non-Hodgkin lymphoma subtypes provide an opportunity to explore associations between environmental exposures and FL incidence. Our paper found that aspects of Western lifestyle including sedentary lifestyle, obesity, and diets high in meat and milk are associated with an increased risk of FL. Diets rich in fruits and vegetables, polyunsaturated fatty acids, vitamin D, and certain antioxidants are inversely associated with FL risk. A medical history of Sjogren's syndrome, influenza vaccination, and heart disease may be associated with FL incidence. Associations between FL and exposure to pesticides, industrial solvents, hair dyes, and alcohol/tobacco were inconsistent. Genetic risk factors include variants at the 6p21.32 region of the MHC II locus, polymorphisms of the DNA repair gene XRCC3, and UV exposure in individuals with certain polymorphisms of the vitamin D receptor. Increasing our understanding of risk factors for FL must involve integrating epidemiological studies of genetics and exposures to allow for the examination of risk factors and interactions between genes and environment.

  4. Observations of the surge-type Black Rapids Glacier, Alaska, during a quiescent period, 1970-92 (United States)

    Heinrichs, Thomas A.; Mayo, L.R.; Trabant, D.C.; March, R.S.


    This report presents 23 years (1970 to 1992) of observations of Black Rapids Glacier, Alaska. Black Rapids Glacier is a surge-type glacier which most recently surged in 1936-37, and is currently in its quiescent phase. This glacier is of special interest because it is a potential hazard to the trans-Alaska oil pipeline. Ten sites on the glacier were monitored from 1972 to 1987, and three sites were monitored from 1988 to 1992. The measurement program presented here includes observations of surface mass balance, ice velocity, and surface altitude made twice each year. Additional one-time data include observations of ice thickness, previously unreported observations of the 1936-37 surge, establishment of the geodetic control monuments, and a new map of Black Rapids Glacier.

  5. Present dynamics and future prognosis of a slowly surging glacier

    Directory of Open Access Journals (Sweden)

    G. E. Flowers


    Full Text Available Glacier surges are a well-known example of an internal dynamic oscillation whose occurrence is not a direct response to the external climate forcing, but whose character (e.g. period, mechanism may depend on the glacier's environmental or climate setting. We examine the dynamics of a small (~5 km2 valley glacier in the Yukon Territory of Canada, where two previous surges have been photographically documented and an unusually slow surge is currently underway. To characterize the dynamics of the present surge, and to speculate on the future of this glacier, we employ a higher-order flowband model of ice dynamics with a Coulomb-friction sliding law in both diagnostic and prognostic simulations. Diagnostic (force balance calculations capture the measured ice-surface velocity profile only when high basal water pressures (55–90% of flotation are prescribed over the central region of the glacier, consistent with where evidence of the surge has been identified. This leads to sliding accounting for 50–100% of the total surface motion. Prognostic simulations, where the glacier geometry evolves in response to a prescribed surface mass balance, reveal a significant role played by a large bedrock bump beneath the current equilibrium line of the glacier. This bump provides resistance to ice flow sufficient to cause the formation of a bulge in the ice-surface profile. We suggest that the bedrock bump contributes to the propensity for surges in this glacier, such that conditions suppressing ice-bulge formation over the bump may also inhibit surges. In our calculations such a situation arises for sufficiently negative values of mass balance. Collectively, these results corroborate our interpretation of the current glacier flow regime as indicative of a "slow surge", and confirm a relationship between surge incidence or character and the net mass balance. Our results also highlight the importance of glacier bed topography in controlling ice

  6. Present dynamics and future prognosis of a slowly surging glacier

    Directory of Open Access Journals (Sweden)

    G. E. Flowers


    Full Text Available Glacier surges are a well-known example of an internal dynamic oscillation whose occurrence is not a direct response to the external climate forcing, but whose character (i.e. period, amplitude, mechanism may depend on the glacier's environmental or climate setting. We examine the dynamics of a small (∼5 km2 valley glacier in Yukon, Canada, where two previous surges have been photographically documented and an unusually slow surge is currently underway. To characterize the dynamics of the present surge, and to speculate on the future of this glacier, we employ a higher-order flowband model of ice dynamics with a regularized Coulomb-friction sliding law in both diagnostic and prognostic simulations. Diagnostic (force balance calculations capture the measured ice-surface velocity profile only when non-zero basal water pressures are prescribed over the central region of the glacier, coincident with where evidence of the surge has been identified. This leads to sliding accounting for 50–100% of the total surface motion in this region. Prognostic simulations, where the glacier geometry evolves in response to a prescribed surface mass balance, reveal a significant role played by a bedrock ridge beneath the current equilibrium line of the glacier. Ice thickening occurs above the ridge in our simulations, until the net mass balance reaches sufficiently negative values. We suggest that the bedrock ridge may contribute to the propensity for surges in this glacier by promoting the development of the reservoir area during quiescence, and may permit surges to occur under more negative balance conditions than would otherwise be possible. Collectively, these results corroborate our interpretation of the current glacier flow regime as indicative of a slow surge that has been ongoing for some time, and support a relationship between surge incidence or character and the net mass balance. Our results also highlight the importance of glacier bed

  7. Surge of the Bivachny Glacier in 2012–2015

    Directory of Open Access Journals (Sweden)

    V. M. Kotlyakov


    Full Text Available The surge of the Bivachny Glacier that occurred in 2012–2015 is analyzed with the use of photographing performed from International Space Station in 2001–2015 together with data of the satellite monitoring of 1972–2000. This surge happened in 31 years after the similar previous event of 1972–1976. Dynamics of numerous glacier branches causing activation of the lower glacier part that is so called “dead” zone (more than 7 km in length is shown. Just before its stop the front part of the surging glacier had reached the main trunk of the Fedchenko Glacier. 

  8. Immunoglobulin light chain immunohistochemistry revisited, with emphasis on reactive follicular hyperplasia versus follicular lymphoma. (United States)

    Weiss, Lawrence M; Loera, Sofia; Bacchi, Carlos E


    The identification of monotypic light chains is an important adjunct to the diagnosis of B-cell lymphoma, yet to reliably perform it on formalin-fixed paraffin sections is often difficult. We have evaluated a new set of monoclonal antibodies to kappa and lambda light chains that are reactive in paraffin sections. In reactive lymphoid tissues, polytypic staining was noted in greater than 95% of cases, with strong staining of plasma cells, moderate staining of the follicular dendritic cell network, and weak staining of mantle zone cells. Strong staining of the appropriate light chain was seen in each of the 7 cases of multiple myeloma. In a series of 58 cases of B-cell lymphoma, correlation between the results of immunohistochemistry and flow cytometry was obtained in 36 cases (62%), including 32 cases (21 kappa and 11 lambda) in which a single light chain was expressed. Monotypic staining was also seen in 6 additional cases (10%) in which flow cytometry was negative. Thirty of 46 cases (65%) of follicular lymphoma showed monotypic light chain expression, in contrast to 64 of 67 cases (95%) of reactive lymphoid hyperplasia, which showed polytypic light chain expression. These antibodies may provide an effective adjunct to the diagnosis of B-cell lymphoma in routine diagnostic work.

  9. Performance of metal oxide gapless surge arresters for HVDC systems

    Energy Technology Data Exchange (ETDEWEB)

    Diseko, N.L.


    An examination of the electrical stresses which may be imposed upon metal oxide surge arresters in a dc converter station is undertaken by means of simulation of the dc system and associated ac systems in the time domain using a digital computer program. Detailed models of a dc link are developed for temporary overvoltage stresses and steep front stresses. The most critical stresses for each type of dc station arrester due to converter faults and converter malfunctions are identified. The energy stresses were generally determined to be dependent on the converter control and protection strategies adopted during the faults. The arrester energy stresses for faults on both the line side and valve side busses of the converter transformer were determined to be sensitive to the instant of fault application and the duration of the fault. The arrester stresses for ac bus faults were analyzed in detail to determine their statistical distribution relative to the point on wave at which the fault occurred in each affected phase, and to the instant of fault clearance in each phase. Generally, the highest stresses occur for sequential fault occurrence in the phases compared with simultaneous faults. The studies indicate that the stresses in the arresters in a dc pile experiencing the worst duty depend on the number of arresters represented. Modelling only one arrester of a series-connected group does not provide correct results when the fault condition imposes duty on more than one of the arresters in the group. The study also indicates that the highest stresses do not necessarily occur in the single arrester connected across the valve with the highest prospective overvoltage. Hence the capability to represent all valve arresters within one pole is necessary when determining the most onerous stresses. 11 refs., 79 figs., 28 tabs.

  10. Cell of origin of transformed follicular lymphoma. (United States)

    Kridel, Robert; Mottok, Anja; Farinha, Pedro; Ben-Neriah, Susana; Ennishi, Daisuke; Zheng, Yvonne; Chavez, Elizabeth A; Shulha, Hennady P; Tan, King; Chan, Fong Chun; Boyle, Merrill; Meissner, Barbara; Telenius, Adele; Sehn, Laurie H; Marra, Marco A; Shah, Sohrab P; Steidl, Christian; Connors, Joseph M; Scott, David W; Gascoyne, Randy D


    Follicular lymphoma (FL) is an indolent disease but transforms in 2% to 3% of patients per year into aggressive, large cell lymphoma, a critical event in the course of the disease associated with increased lymphoma-related mortality. Early transformation cannot be accurately predicted at the time of FL diagnosis and the biology of transformed FL (TFL) is poorly understood. Here, we assembled a cohort of 126 diagnostic FL specimens including 40 patients experiencing transformation (transformation for at least 5 years. In addition, we assembled an overlapping cohort of 155 TFL patients, including 114 cases for which paired samples were available, and assessed temporal changes of routinely available biomarkers, outcome after transformation, as well as molecular subtypes of TFL. We report that the expression of IRF4 is an independent predictor of early transformation (Hazard ratio, 13.3; P transformation predicts favorable prognosis. Moreover, applying the Lymph2Cx digital gene expression assay for diffuse large B-cell lymphoma (DLBCL) cell-of-origin determination to 110 patients with DLBCL-like TFL, we demonstrate that TFL is of the germinal-center B-cell-like subtype in the majority of cases (80%) but that a significant proportion of cases is of the activated B-cell-like (ABC) subtype (16%). These latter cases are commonly negative for BCL2 translocation and arise preferentially from BCL2 translocation-negative and/or IRF4-expressing FLs. Our study demonstrates the existence of molecular heterogeneity in TFL as well as its relationship to the antecedent FL.

  11. Decitabine in Treating Patients With Metastatic Papillary Thyroid Cancer or Follicular Thyroid Cancer Unresponsive to Iodine I 131 (United States)


    Recurrent Thyroid Cancer; Stage IVA Follicular Thyroid Cancer; Stage IVA Papillary Thyroid Cancer; Stage IVB Follicular Thyroid Cancer; Stage IVB Papillary Thyroid Cancer; Stage IVC Follicular Thyroid Cancer; Stage IVC Papillary Thyroid Cancer

  12. U.S. Glaucoma Cases Expected to Surge by 2030 (United States)

    ... page: U.S. Glaucoma Cases Expected to Surge by 2030 Routine ... Medicine, the National Institutes of Health, or the U.S. Department of Health and Human Services. Recent Health ...

  13. Zika-Linked Birth Defects Surge in Colombia: CDC (United States)

    ... page: Zika-Linked Birth Defects Surge in Colombia: CDC Study ... born with devastating birth defects linked to the Zika virus is no longer confined to Brazil, a ...

  14. Storm surge model based on variational data assimilation method

    Institute of Scientific and Technical Information of China (English)

    Shi-li HUANG; Jian XU; De-guan WANG; Dong-yan LU


    By combining computation and observation information,the variational data assimilation method has the ability to eliminate errors caused by the uncertainty of parameters in practical forecasting.It was applied to a storm surge model based on unstructured grids with high spatial resolution meant for improving the forecasting accuracy of the storm surge.By controlling the wind stress drag coefficient,the variation-based model was developed and validated through data assimilation tests in an actual storm surge induced by a typhoon.In the data assimilation tests,the model accurately identified the wind stress drag coefficient and obtained results close to the true state.Then,the actual storm surge induced by Typhoon 0515 was forecast by the developed model,and the results demonstrate its efficiency in practical application.

  15. Hemimandibulectomy with full angular mandibular plate reconstruction follicular Ameloblastoma patient

    Directory of Open Access Journals (Sweden)

    Susanti Bulan


    Full Text Available Introduction :Ameloblastoma is an aggressive benign of odontogenic origin tumor; cystic shape, slowly growth; no pain; local invasive; infiltrate muscle; and bone destruction. Based on histopathology ameloblastomas are classified: Follicular, acanthomatous, granular cell, basal cell, and plexiform. Follicular and plexiformameloblastomas are the most common, with incidence rates 27.7% and 21.1%. Follicular ameloblastoma is characterized by recurrence rate (29.5%; plexiformameloblastoma (16.7%; and acanthomatousameloblastoma (4.5%. Early diagnosis with prompt and adequate management decrease recurrence and get good prognosis. Objective : to evaluate recurrence of follicular ameloblastoma after surgery; to evaluate  stomatognatic function and aesthetic problems. Case report : a 55 y.o. female patient with lump at left cheek since 1 year before admission; initially was small in size; gradually increased, no history of trauma, pain, febrile, and discharge. Based on clinical, histopathological, radiological, CT scan, it was diagnosed follicular ameloblastoma. The treatment was left hemimandibulectomy with full angular mandibular plate reconstruction. Discussion :Ameloblastoma is a locally destructive tumor with recurrence if not entirely excised. The goal of treatment ameloblastoma is wide excision and reconstruction of surgical defect. Then, it is followed up to evaluate recurrence, stomatognatic function, and aesthetic problems. Conclusion : Prognosis is good if an early diagnosis of the lesion is made with prompt and adequate surgical intervention.

  16. Observations of cyclone-induced storm surge in coastal Bangladesh


    Chiu, Soyee; Small, Christopher


    Water level measurements from 15 tide gauges in the coastal zone of Bangladesh are analyzed in conjunction with cyclone tracks and wind speed data for 54 cyclones between 1977 and 2010. Storm surge magnitude is inferred from residual water levels computed by subtracting modeled astronomical tides from observed water levels at each station. Observed residual water levels are generally smaller than reported storm surge levels for cyclones where both are available, and many cyclones produce no o...

  17. Modeling and control of surge and rotating stall in compressors

    Energy Technology Data Exchange (ETDEWEB)

    Gravdahl, Jan Tommy


    Compressors are used in power generation and a variety of other applications. This thesis contains new results in the field of modeling and control of rotating stall and surge in compressors. A close coupled valve is included in the Moore-Greitzer compression system model and controllers for both surge and rotating stall is derived using backstepping. Disturbances, constant and time varying, are then taken into account, and non-linear controllers are derived. Stability results are given. Then, passivity is used to derive a simple surge control law for the closed coupled valve. This propositional control law is shown to stabilize the system even in the presence of time varying disturbances in mass flow and pressure. A novel model for an axial compression system with non-constant compressor speed is derived by extending the Moore-Greitzer model. Rotating stall and surge is studied in connection with acceleration of the compressor. Finally, a model for a centrifugal compression system with time varying compressor speed is derived. The variable speed compressor characteristic is derived based on energy losses in the compressor components. Active control of surge in connection with varying speed is studied. Semi-global exponential stability of the compression system with both surge and speed control is proven. 103 refs., 38 figs., 5 tabs.

  18. The role of mangroves in attenuating storm surges (United States)

    Zhang, Keqi; Liu, Huiqing; Li, Yuepeng; Xu, Hongzhou; Shen, Jian; Rhome, Jamie; Smith, J.


    Field observations and numerical simulations indicate that the 6-to-30-km-wide mangrove forest along the Gulf Coast of South Florida effectively attenuated stormsurges from a Category 3 hurricane, Wilma, and protected the inland wetland by reducing an inundation area of 1800 km2 and restricting surge inundation inside the mangrove zone. The surge amplitude decreases at a rate of 40–50 cm/km across the mangrove forest and at a rate of 20 cm/km across the areas with a mixture of mangrove islands with open water. In contrast, the amplitudes of stormsurges at the front of the mangrove zone increase by about 10–30% because of the "blockage" of mangroves to surge water, which can cause greater impacts on structures at the front of mangroves than the case without mangroves. The mangrove forest can also protect the wetlands behind the mangrove zone against surge inundation from a Category 5 hurricane with a fast forward speed of 11.2 m/s (25 mph). However, the forest cannot fully attenuate stormsurges from a Category 5 hurricane with a slow forward speed of 2.2 m/s (5 mph) and reduced surges can still affect the wetlands behind the mangrove zone. The effects of widths of mangrove zones on reducing surge amplitudes are nonlinear with large reduction rates (15–30%) for initial width increments and small rates (<5%) for subsequent width increments.

  19. A New Engineering Method for Fuzzy Reliability Analysis of Surge Control in Centrifugal Compressor

    Directory of Open Access Journals (Sweden)

    Ahmed Hafaifa


    Full Text Available Problem statement: The surge phenomenon in the centrifugal compressor, the non-linearities and uncertainties of the compression system make it impossible to use a conventional controller over a wide range of operation. Approach: A new dual fuzzy controller for nonlinear model of compression system was proposed in this study. This fuzzy controller was designed that consisted of active surge control and phase control without any explicit system models, but driven in human thinking mechanism. Results: Simulation example of compression system was given to demonstrate the validity of proposed control scheme. It was shown that fuzzy controller can be simplified and good tracking control performance can be achieved by choosing appropriate fuzzy roles. But, the dual fuzzy controller can successfully intervene in control surge of compression system. Conclusion: This new fuzzy control methodology suggested in this study reproduced well main characteristics of turbo compressor dynamic model developed by Moore and Gretzer and give place to a more precise and easy to handle representation. It is about an inaccuracies reproducing with a certain degree of satisfaction of real process without being as much complex.

  20. Memory T follicular helper CD4 T cells

    Directory of Open Access Journals (Sweden)

    J. Scott eHale


    Full Text Available T follicular helper (Tfh cells are the subset of CD4 T helper cells that are required for generation and maintenance of germinal center reactions and the generation of long-lived humoral immunity. This specialized T helper subset provides help to cognate B cells via their expression of CD40 ligand, IL-21, IL-4, and other molecules. Tfh cells are characterized by their expression of the chemokine receptor CXCR5, expression of the transcriptional repressor Bcl6, and their capacity to migrate to the follicle and promote germinal center B cell responses. Until recently, it remained unclear whether Tfh cells differentiated into memory cells and whether they maintain their Tfh commitment at the memory phase. This review will highlight several recent studies that support the idea of Tfh-committed CD4 T cells at the memory stage of the immune response. The implication of these findings is that memory Tfh cells retain their capacity to recall their Tfh-specific effector functions upon reactivation to provide help for B cell responses and play an important role in prime and boost vaccination or during recall responses to infection. The markers that are useful for distinguishing Tfh effector and memory cells, as well as the limitations of using these markers will be discussed. Tfh effector and memory generation, lineage maintenance, and plasticity relative to other T helper lineages (Th1, Th2, Th17, etc will also be discussed. Ongoing discoveries regarding the maintenance and lineage stability versus plasticity of memory Tfh cells will improve strategies that utilize CD4 T cell memory to modulate antibody responses during prime and boost vaccination.

  1. Ovarian Follicular Atresia of Ewes during Spring Puerperium

    Directory of Open Access Journals (Sweden)

    Radoslava Vlčková


    Full Text Available The distribution of healthy and atretic follicles on the ovarian surface of improved Valachian ewes 17, 24, and 32 days postpartum is reported in this study. The number of healthy follicles was higher on day 24 postpartum and their mean diameter tended to increase to day 32 (P<0.05 with the greatest diameter of 5 mm. 78–81% of atretic follicles ≥3 mm in diameter was observed where apoptosis began in the follicular cells situated at the follicular cavity. The early atretic follicles are characterized by the presence of mitotic pictures. In one ewe 24 days postpartum, small regressive follicular cysts were observed. Contracting atresia is characterized by thickening of the theca interna even to 190 μm. Progesterone and oestradiol-17β concentrations were maintained at relatively low levels, but with no significant difference between the days postpartum.

  2. Treatment of follicular NHL: The old and the new (United States)

    Friedberg, Jonathan W.


    Despite remaining an incurable disease, overall survival improvements have been noted in patients with advanced stage follicular lymphoma. The Follicular Lymphoma International Prognostic Index (FLIPI) is a robust prognostic index in this disease, and continues to provide prognostic information in the rituximab era. Rituximab has significantly changed the management of follicular lymphoma, and the most dramatic impact of rituximab is observed in combination with cytotoxic chemotherapy. However, resistance to rituximab remains a problem, and standard therapy in the rituximab-refractory setting includes radioimmunotherapy, autologous stem cell transplantation, and allogeneic stem cell transplantation. In addition, several novel agents show encouraging activity in FL, including bendamustine, lenalidomide, bortezomib and other proteasome inhibitors, and BCL2 inhibitors. PMID:18760706

  3. Follicular atresia in the prepubertal spiny mouse (Acomys cahirinus) ovary. (United States)

    Hułas-Stasiak, Monika; Gawron, Antoni


    This study was designed to determine follicular atresia in the newborn and the prepubertal spiny mouse. We analyzed the processes of follicle loss using classical markers of apoptosis (TUNEL reaction, active caspase-3) and autophagy (Lamp1). Numerous small clear vacuoles and autophagosomes as well as strong Lamp1 staining were observed in dying oocytes of all follicle types, especially of the primordial and primary ones. Active caspase 3 and the TUNEL reaction were detected only in the granulosa cells of large secondary and antral follicles. The expression of apoptosis and autophagy markers was also changing during the prepubertal period. Western blot analysis indicated that at the moment of birth, females undergo an increased rate of follicular atresia mediated by autophagy, while apoptosis is the dominant form of ovarian atresia in consecutive postnatal days. On the basis of these observations, we concluded that apoptosis and autophagy are involved in follicular atresia and these processes are cell and developmental stage-specific.

  4. T follicular regulatory cells in mice and men. (United States)

    Maceiras, Ana Raquel; Fonseca, Valter R; Agua-Doce, Ana; Graca, Luis


    It has long been known that CD4 T cells are necessary to provide help to B cells, triggering a germinal centre (GC) reaction where affinity maturation and isotype switching occur. However, the nature of the dedicated CD4 helper T cells, known as T follicular helper (Tfh), was only recently described. Here, we review the biology and function of the recently described T follicular regulatory (Tfr) cells, another CD4 T-cell population also found within GCs but with regulatory function and characteristics. Tfr cells have been identified in mice and humans as simultaneously presenting characteristics of T follicular cells (namely CXCR5 expression) and regulatory T cells (including Foxp3 expression). These Tfr cells have been implicated in the regulation of the magnitude of the GC reaction, as well as in protection from immune-mediated pathology. © 2017 John Wiley & Sons Ltd.

  5. Beard Reconstruction with Follicular-unit Hair Grafting Technique

    Institute of Scientific and Technical Information of China (English)

    LIU Qing; WEI Xian; LI Qing-feng


    Objective To reconstruct beard with single-follicular-unit grafts in patients with upper lip scar.Methods From May 2001 to May 2005, one-hair follicular units were harvested to treat 20 patients with partial beard loss due to scar formation, 9 out of whom resulting from repair of congenital lip cleft. During the operation, a 1-2mm two-edged sapphire knife was used to make micro-slits. Results A 6-month follow-up revealed that 20 patients recovered quickly and looked natural, with small blood loss and high survival rate, yet 3 with severe scar needed a two-stage operation. Conclusion One-hair follicular unit transplantation is a good option for patients with cicatrical beard loss.

  6. Inhibin-B secretion and FSH isoform distribution may play an integral part of follicular selection in the natural menstrual cycle

    DEFF Research Database (Denmark)

    Yding Andersen, C


    The aim of the present paper is to expand the concept on how follicular selection takes place in the follicular phase of the natural menstrual cycle. It is suggested that inhibin-B exerts a more intimate role in this process than previously understood. Inhibin-B shows a peak in the circulation....... Collectively, it appears that inhibin-B is an integral part of follicular selection in the normal menstrual cycle, exerting both endocrine and paracrine effects and facilitating continued growth of the selected follicle....... around cycle day 7, simultaneous with selection of the dominant follicle, whereas levels of estradiol and inhibin-A only start to increase a few days later suggesting that inhibin-B is mainly responsible for downregulating pituitary FSH release. New data now demonstrate that the circulatory peak...

  7. Improved PV system reliability results from surge evaluations at Sandia National Laboratories

    Energy Technology Data Exchange (ETDEWEB)

    Russell H. Bonn; Sigifredo Gonzalez


    Electrical surges on ac and dc inverter power wiring and diagnostic cables have the potential to shorten the lifetime of power electronics. These surges may be caused by either nearby lightning or capacitor switching transients. This paper contains a description of ongoing surge evaluations of PV power electronics and surge mitigation hardware at Sandia.

  8. Immunoblastic follicular lymphoma: a very unusual transformation of low-grade follicular lymphoma. (United States)

    Gheith, Shereen; Cornfield, Dennis; Chen, Weiyi; Singh-Kahlon, Pal; Ahmed, Basil


    A 73-year-old man, in clinical remission 17 years after radiation therapy for a localized low-grade follicular lymphoma (FL), developed extensive lymphadenopathy, ascites, and splenomegaly with splenic masses. Axillary lymph node biopsy showed FL composed of nodules of centrocytes side by side with nodules of immunoblasts rather than centroblasts. Immunophenotyping revealed conventional FL markers (BCL-2, BCL-6, and CD10) as well as MUM-1 in the immunoblastic component, suggesting postgerminal center differentiation. Fluorescence in situ hybridization showed t(14;18) in both centrocytic and immunoblastic components and a copy gain of BCL-6 predominantly in the immunoblastic component. Areas of centrocytic and of immunoblastic nodules were macrodissected separately and underwent molecular evaluation for immunoglobulin heavy chain gene rearrangement. Identical base-pair peaks were found, attesting to their clonal identity. This case represents a very unusual example of transformation of a low-grade FL to a nodular immunoblastic FL.

  9. Surge-type glaciers in the Tien Shan (Central Asia) (United States)

    Mukherjee, Kriti; Bolch, Tobias


    Surge-type glaciers in High Mountain Asia are mostly observed in Karakoram and Pamir. However, few surge-type glaciers also exist in the Tien Shan, but have not comprehensively studied in detail in the recent literature. We identified surge-type glaciers in the Tien Shan either from available literature or by manual interpretation using available satellite images (such as Corona, Hexagon, Landsat, SPOT, IRS) for the period 1960 to 2014. We identified 39 possible surge-type glaciers, showing typical characteristics like looped moraines. Twenty-two of them rapidly advanced during different periods or a surge was clearly described in the literature. For the remaining possible surge-type glaciers either the advance, in terms of time and length, were not mentioned in detail in the literature, or the glaciers have remained either stable or retreated during the entire period of our study. Most of the surge-type glaciers cluster in the Inner Tien Shan (especially in the Ak-Shiirak rage) and the Central Tien Shan, are in size and are facing North, West or North West. Pronounced surge events were observed for North Inylchek and Samoilowitsch glaciers, both of which are located in the Central Tien Shan. Samoilowitsch Glacier retreated by more than 3 km between 1960 (length ~8.9 km) and 1992 (~5.8 km), advanced by almost 3 km until 2006 and slightly retreated thereafter. The most pronounced advance occurred between 2000 and 2002. DEM differencing (based on SRTM3 data and stereo Hexagon and Cartosat-1 data) revealed a significant thickening in the middle reaches (reservoir area) of the glacier between 1973 and 2000 while the surface significantly lowered in the middle and upper parts of the glacier between 2000 and 2006. Hence, the ice mass was transferred to the lower reaches (receiving area) and caused the advance with a maximum thickening of more than 80 m. The ~30 km long North Inylchek Glacier retreated since 1943 and showed a very rapid advance of ~3.5 km especially in

  10. The influence of climate during and after a glacial surge - A comparison of the last two surges of Fridtjovbreen, Svalbard (United States)

    Lønne, Ida


    Glacial surges are periods of fast flow, often limited in space and time, and driven by internal conditions which are not fully explained. The quantity and variety of documented case-studies and settings demonstrate that the critical variables are difficult to isolate. In an alternative approach, two surges from the same basin were compared at Fridtjovhamna; one of the few known sites where this is possible. Fridtjovbreen is a polythermal glacier that has been through two recent surges: the last event (1991-2002) occurred during an unusually warm period in the high Arctic, whereas the previous surge culminated in 1861, around the Little Ice Age when many Svalbard-glaciers had their maximum Holocene extent. Based on a multi-disciplinary study, processes and landforms from the two episodes were compared with respect to ice-front movement rates, formation and decay of ice-cored moraines and glacial meltwater drainage patterns. The study demonstrates that moraines and meltwater traces from the oldest surge, locally well preserved, provide excellent opportunities for reconstructing the behavior of the ice-mass. The last surge, however, took place during a period with ablation rates never seen at this latitude, and 10 years after the maximum extent, the deglaciated areas onshore hardly show traces from the event.

  11. Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia

    Directory of Open Access Journals (Sweden)

    Shamma RN


    Full Text Available Rehab Nabil Shamma, Mona Hassan AburahmaDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, EgyptAbstract: Spironolactone (SL is a US Food and Drug Administration-approved drug for the treatment of hypertension and various edematous conditions. SL has gained a lot of attention for treating androgenic alopecia due to its potent antiandrogenic properties. Recently, there has been growing interest for follicular targeting of drug molecules for treatment of hair and scalp disorders using nanocolloidal lipid-based delivery systems to minimize unnecessary systemic side effects associated with oral drug administration. Accordingly, the objective of this study is to improve SL efficiency and safety in treating alopecia through the preparation of colloidal nanostructured lipid carriers (NLCs for follicular drug delivery. SL-loaded NLCs were prepared by an emulsion solvent diffusion and evaporation method using 23 full factorial design. All of the prepared formulations were spherical in shape with nanometric size range (215.6–834.3 nm and entrapment efficiency >74%. Differential scanning calorimetry thermograms and X-ray diffractograms revealed that SL exists in amorphous form within the NLC matrices. The drug release behavior from the NLCs displayed an initial burst release phase followed by sustained release of SL. Confocal laser scanning microscopy confirmed the potential of delivering the fluorolabeled NLCs within the follicles, suggesting the possibility of using SL-loaded NLCs for localized delivery of SL into the scalp hair follicles.Keywords: spironolactone, androgenic alopecia, nanostructured lipid carriers, follicular targeting, confocal laser scanning microscopy

  12. Melanins as biomarkers of ovarian follicular atresia in the catfish Heteropneustes fossilis: biochemical and histochemical characterization, seasonal variation and hormone effects. (United States)

    Kumar, Ravi; Joy, Keerikkattil P


    Follicular atresia is a common feature of the vertebrate ovary that occurs at different stages of folliculogenesis and ovarian regression. It has physiological significance to maintain homeostasis and control fecundity, and ensure removal of post-ovulatory follicular remnants for preparing the ovary for the next cycle. Pigments appear late in the atretic process as indigestible waste formed out of the degradation of the oocytes, follicle wall and granulocytes. In the present study, pigment accumulation was demonstrated by Schmorl's and Perls' staining methods in the atretic ovarian follicles of Heteropneustes fossilis during follicular development and regression. Melanins were characterized spectrophotometrically for the first time in fish ovary. The predominant form is eumelanin, followed by pheomelanin and alkali-soluble melanin. Melanins showed significant seasonal variations with levels low in gonad resting phase, increasing to the peak in the post-spawning phase. The concentration of melanins increased time-dependently in post-ovulated ovary after human chorionic gonadotropin treatment. In the spawning phase, in vitro incubation of ovary slices with estradiol-17β or dexamethasone for 8 or 16 h decreased both eumelanin and pheomelanin levels time-dependently. The alkali-soluble melanin showed a significant decrease only in the dexamethasone group at 16 h. The results show that melanin assay can be used as a biomarker of follicular atresia in fish ovary, natural or induced by environmental toxicants.

  13. A High Density Storm Surge Monitoring Network: Evaluating the Ability of Wetland Vegetation to Reduce Storm Surge (United States)

    Lawler, S.; Denton, M.; Ferreira, C.


    Recent tropical storm activity in the Chesapeake Bay and a potential increase in the predicted frequency and magnitude of weather systems have drawn increased attention to the need for improved tools for monitoring, modeling and predicting the magnitude of storm surge, coastal flooding and the respective damage to infrastructure and wetland ecosystems. Among other forms of flood protection, it is believed that coastal wetlands and vegetation can act as a natural barrier that slows hurricane flooding, helping to reduce the impact of storm surge. However, quantifying the relationship between the physical process of storm surge and its attenuation by wetland vegetation is an active area of research and the deployment of in-situ measuring devices is crucial to data collection efforts in this field. The United States Geological Survey (USGS) mobile storm-surge network has already successfully provided a framework for evaluating hurricane induced storm surge water levels on a regional scale through the use of in-situ devices installed in areas affected by storm surge during extreme events. Based on the success of the USGS efforts, in this study we adapted the monitoring network to cover relatively small areas of wetlands and coastal vegetation with an increased density of sensors. Groups of 6 to 10 water level sensors were installed in sites strategically selected in three locations on the Virginia coast of the lower Chesapeake Bay area to monitor different types of vegetation and the resulting hydrodynamic patterns (open coast and inland waters). Each group of sensors recorded time series data of water levels for both astronomical tide circulation and meteorological induced surge. Field campaigns were carried out to survey characteristics of vegetation contributing to flow resistance (i.e. height, diameter and stem density) and mapped using high precision GPS. A geodatabase containing data from field campaigns will support the development and calibration of

  14. Two-miRNA classifiers differentiate mutation-negative follicular thyroid carcinomas and follicular thyroid adenomas in fine needle aspirations with high specificity

    DEFF Research Database (Denmark)

    Stokowy, Tomasz; Wojtas, Bartosz; Jarzab, Barbara


    Diagnosis of thyroid by fine needle aspiration is challenging for the "indeterminate" category and can be supported by molecular testing. We set out to identify miRNA markers that could be used in a diagnostic setting to improve the discrimination of mutation-negative indeterminate fine needle...... aspirations. miRNA high-throughput sequencing was performed for freshly frozen tissue samples of 19 RAS and PAX8/PPARG mutation-negative follicular thyroid carcinomas, and 23 RAS and PAX8/PPARG mutation-negative follicular adenomas. Differentially expressed miRNAs were validated by quantitative polymerase...... chain reaction in a set of 44 fine needle aspiration samples representing 24 follicular thyroid carcinomas and 20 follicular adenomas. Twenty-six miRNAs characterized by a significant differential expression between follicular thyroid carcinomas and follicular adenomas were identified. Nevertheless...

  15. Methodology for surge pressure evaluation in a water injection system

    Energy Technology Data Exchange (ETDEWEB)

    Meliande, Patricia; Nascimento, Elson A. [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Dept. de Engenharia Civil; Mascarenhas, Flavio C.B. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Lab. de Hidraulica Computacional; Dandoulakis, Joao P. [SHELL of Brazil, Rio de Janeiro, RJ (Brazil)


    Predicting transient effects, known as surge pressures, is of high importance for offshore industry. It involves detailed computer modeling that attempts to simulate the complex interaction between flow line and fluid in order to ensure efficient system integrity. Platform process operators normally raise concerns whether the water injection system is adequately designed or not to be protected against possible surge pressures during sudden valve closure. This report aims to evaluate the surge pressures in Bijupira and Salema water injection systems due to valve closure, through a computer model simulation. Comparisons among the results from empirical formulations are discussed and supplementary analysis for Salema system were performed in order to define the maximum volumetric flow rate for which the design pressure was able to withstand. Maximum surge pressure values of 287.76 bar and 318.58 bar, obtained in Salema and Bijupira respectively, using empirical formulations have surpassed the operating pressure design, while the computer model results have pointed the greatest surge pressure value of 282 bar in Salema system. (author)

  16. Cold surge: a sudden and spatially varying threat to health? (United States)

    Yang, Tse-Chuan; Wu, Pei-Chih; Chen, Vivian Yi-Ju; Su, Huey-Jen


    While cold surge is one of the most conspicuous features of the winter monsoon in East Asia, its impact on human health remains underexplored. Based on the definition by the Central Weather Bureau in Taiwan, we identified four cold surges between 2000 and 2003 and collected the cardiovascular disease mortality data 2 weeks before and 2 weeks after these events. We attempted to answer the following research questions: 1) whether the cold surges impose an adverse and immediate effect on cardiovascular mortality; 2) whether the people living in temperate zones have a higher tolerance of extreme temperature drop than those in the subtropics. With geographic weighting techniques, we not only found that the cardiovascular disease mortality rates increased significantly after the cold surges, but also discovered a spatially varying pattern of tolerance to cold surges. Even within a small study area such as Taiwan, human reaction to severe weather drop differs across space. Needless to say, in the U.S., these findings should be considered in redirecting policy to address populations living in warm places when extreme temperature drops occur.

  17. Advances in hair transplantation: longitudinal partial follicular unit transplantation. (United States)

    Gho, Coen G; Neumann, H A Martino


    There are different techniques of hair transplantation. The most common and known hair transplantation methods are the 'strip' method, where a strip of skin containing hair follicles is removed, cut into grafts and implanted in the recipient area, and the follicle unit extraction (FUE) method, in which whole follicle units are extracted one by one and implanted one by one back into the recipient area. The FUE method is more patient friendly and leaves only tiny scars compared to the strip method, which leaves visible linear scars at the donor area. Both methods, however, have the major disadvantage that the extracted hair follicles are removed and the availability of donor hair follicles are limited and results in a decrease in hair density, as no re-grow will occur in the donor area. Since partial longitudinal-follicular unit transplantation (PL-FUT) extracts partial longitudinal follicular units that can be used as complete follicular units to regenerate completely differentiated hair growth and the partial follicular units that remain in the dermis in the donor area can survive and produce hair, PL-FUT enables us to multiply hair follicles in vivo while preserving the donor area. Although this technique is suitable for androgenic alopecia, PL-FUT could also be suitable in persons who have a relative small donor area compared to the recipient area like burn victims, as well as scarring alopecia's like frontal fibrosing alopecia.

  18. Ovarian follicular dynamics in purebred and crossbred Boran cows ...

    African Journals Online (AJOL)

    Tuoyo Aghomotsegin


    Aug 17, 2016 ... resulting from normal ovarian follicular dynamics is crucial to ... 18.5°C and average annual rainfall was 757 mm (DZARC Agro- meteorology, 2015). Seventeen cows (9 ..... support of this study by the United States Department of ... Veterinary Sciences, James Cook University, Queensland, Australia. 327 p.

  19. Follicular and percutaneous penetration pathways of topically applied minoxidil foam. (United States)

    Blume-Peytavi, Ulrike; Massoudy, Lida; Patzelt, Alexa; Lademann, Jürgen; Dietz, Ekkehart; Rasulev, Utkur; Garcia Bartels, Natalie


    In the past, it was assumed that the intercellular route was the only relevant penetration pathway for topically applied substances. Recent results on follicular penetration emphasize that the hair follicles represent a highly relevant and efficient penetration pathway and reservoir for topically applied substances. This study investigates a selective closure technique of hair follicle orifices in vivo assessing interfollicular and follicular absorption rates of topical minoxidil foam in humans. In delimited skin area, single hair orifices or interfollicular skin were blocked with a microdrop of special varnish-wax-mixture in vivo. Minoxidil foam (5%) was topically applied, and transcutaneous absorption was measured by a new surface ionization mass spectrometry technique in serum. Different settings (open, closed or none of both) enabled to clearly distinguish between interfollicular and follicular penetration of the topically applied minoxidil foam. Five minutes after topical application, minoxidil was detected in blood samples when follicles remained open, whereas with closed follicles 30 min were needed. Highest levels were found first when both pathways were open, followed by open follicles and subsequently by closed follicles. These results demonstrate the high importance of the follicular penetration pathway. Hair follicles are surrounded by a dense network of blood capillaries and dendritic cells and have stem cells in their immediate vicinity, making them ideal targets for drug delivery. Copyright © 2010 Elsevier B.V. All rights reserved.

  20. A fine romance: T follicular helper cells and B cells. (United States)

    King, Cecile


    T follicular helper (Tfh) cells help B cells to generate affinity-matured antibodies. Three papers in this issue of Immunity (Choi et al., 2011; Kerfoot et al., 2011; Kitano et al., 2011) provide information about the reciprocal relationship between B cells and Tfh cells. Copyright © 2011 Elsevier Inc. All rights reserved.

  1. Pathologic splenic rupture in a patient with follicular lymphoma

    Directory of Open Access Journals (Sweden)

    Aniruddha P Dayama


    Full Text Available Follicular lymphoma (FL is the most common indolent Non Hodgkin’s lymphoma (NHL . It presents primarily with widespread disease which may be asymptomatic and involves the bone marrow in around 40% of patients . Although the disease is widespread at presentation the incidence of complications such as splenic rupture which are usually seen with other aggressive lymphomas is rare

  2. Geometric evolution of the Horcones Inferior Glacier (Mount Aconcagua, Central Andes) during the 2002-2006 surge (United States)

    Pitte, Pierre; Berthier, Etienne; Masiokas, Mariano H.; Cabot, Vincent; Ruiz, Lucas; Ferri Hidalgo, Lidia; Gargantini, Hernán.; Zalazar, Laura


    The Central Andes of Chile and Argentina (31-35°S) contain a large number and variety of ice masses, but only two surging glaciers have been studied in this region. We analyzed the 2002-2006 surge of the Horcones Inferior Glacier, Mount Aconcagua, Argentina, based on medium spatial resolution (15-30 m) satellite images and digital elevation models. During the buildup phase the glacier was stagnant, with velocities lower than 0.1 m/d. In the active-phase velocities reached 14 m/d and the glacier front advanced 3.1 km. At the peak of the active phase (2003-2004), the area-averaged elevation change was -42 m in the reservoir zone (2.53 km2) and +30 m in the receiving zone (3.31 km2). The estimated ice flux through a cross section located at 4175 meter above sea level was 108 m3 during a period of 391 days, a flux that suggests a mean glacier thickness at this location of ~90 m. The depletion phase showed a recovery of the reservoir zone elevation, the down wasting of the receiving zone (-17 m, 2007-2014), and a return to quiescent velocities. The short active phase, the abrupt change in the velocities, and the high level of the proglacial stream indicate a hydrological switch (Alaska type) trigger. The 2002-2006 and 1984-1990 surges of Horcones Inferior were synchronous with the surges of nearby Grande del Nevado Glacier. These events occurred after periods of positive mass balance, so we hypothesize a climate driver.


    Mikhaĭlova, M V; Zubarovskiĭ, I N; Osipenko, S K


    The article is based on the treatment results of 44 patients with follicular tunor of thyroid gland. A staged morphological assessment of thyroid nodes was performed for all patients: in case of preoperative fine-needle biopsy, urgent intraoperative study and according to results of final histological research. The urgent histological study of surgical material was conducted for 44 patients with diagnosis "follicular tumor" according to fine-needle biopsy. The data of final histological study were matched with findings of intraoperative research. A micro-follicular adenoma was detected in 22 patients (50%) and 6 (13,6%) patients had this diagnosis combined with autoimmune thyroiditis. The general part of patients didn't changed in final study, but the rate of diagnosis "micro-follicular adenoma against the background of autoimmune thyroiditis" increased. Papillary carcinoma was revealed in 5 (11,4%) patients and follicular cancer had 4 (9,1%) patients detected in intraoperative study and 3 (6,8%) more patients according to data of final research. The histopathologic feature of colloid goiter was observed in 7 (15,9%) cases and a part of such patients reduced to 6,8% during final study. One of the patients (2,3%) had final diagnosis "oncocytoma". In case of thyroid nodules detection the needle biopsy should be carried out regardless to the size of nodule. The authors recommended performing the surgery with the urgent histological study in case of undetermined histological report. The following surgical strategy was specified by the results of the urgent histological report.

  4. Storm surges in the Western Black Sea. Operational forecasting

    Directory of Open Access Journals (Sweden)



    Full Text Available The frequency of the storm surges in the Black Sea is lower than that in other regions of the World Ocean but they cause significant damages as the magnitude of the sea level set-up is up to 7-8 times greater than that of other sea level variations. New methods and systems for storm surge forecasting and studying their statistical characteristics are absolutely necessary for the purposes of the coastal zone management. The operational forecasting storm surge model of Meteo-France was adopted for the Black Sea in accordance with the bilateral agreement between Meteo-France and NINMH. The model was verified using tide-gauge observations for the strongest storms observed along the Bulgarian coast over the last 10 years.

  5. A numerical storm surge forecast model with Kalman filter

    Institute of Scientific and Technical Information of China (English)

    Yu Fujiang; Zhang Zhanhai; Lin Yihua


    Kalman filter data assimilation technique is incorporated into a standard two-dimensional linear storm surge model. Imperfect model equation and imperfect meteorological forcimg are accounted for by adding noise terms to the momentum equations. The deterministic model output is corrected by using the available tidal gauge station data. The stationary Kalman filter algorithm for the model domain is calculated by an iterative procedure using specified information on the inaccuracies in the momentum equations and specified error information for the observations. An application to a real storm surge that occurred in the summer of 1956 in the East China Sea is performed by means of this data assimilation technique. The result shows that Kalman filter is useful for storm surge forecast and hindcast.

  6. Electromagnetic computation methods for lightning surge protection studies

    CERN Document Server

    Baba, Yoshihiro


    This book is the first to consolidate current research and to examine the theories of electromagnetic computation methods in relation to lightning surge protection. The authors introduce and compare existing electromagnetic computation methods such as the method of moments (MOM), the partial element equivalent circuit (PEEC), the finite element method (FEM), the transmission-line modeling (TLM) method, and the finite-difference time-domain (FDTD) method. The application of FDTD method to lightning protection studies is a topic that has matured through many practical applications in the past decade, and the authors explain the derivation of Maxwell's equations required by the FDTD, and modeling of various electrical components needed in computing lightning electromagnetic fields and surges with the FDTD method. The book describes the application of FDTD method to current and emerging problems of lightning surge protection of continuously more complex installations, particularly in critical infrastructures of e...

  7. Transport conditions of mountain-surging glaciers as recorded in the micromorphology of quartz grains (Medvezhiy Glacier, West Pamir

    Directory of Open Access Journals (Sweden)

    Muzińska Agnieszka


    Full Text Available In order to reproduce the conditions under which sediments were transported in surging glaciers, samples were taken from the margin and foreland of the surge Medvezhiy Glacier situated in West Pamir (Tajikistan. They were subjected to an analysis of rounding and frosting of quartz sand grains (0.8-1.0 mm and of grain surface micromorphology under scanning electron microscope (SEM. Results obtained showed intense chemical weathering occurred in the majority of quartz grain surfaces, marked in the form of etching and precipitation. Frequencies of microstructures of glacial origin were low; individual microstructures were visible on single grains. A predominance of the crushing process over abrasion in transformation of quartz grains was noted. The commonest microstructures connected with a surge-glacier environment were large and small conchoidal fractures. However, grains with primary features not connected with a glacial environment were equally common. The majority of the grains examined showed features of multiple cycles of mechanical and chemical weathering forming a microtexture under various conditions (overprinting. Common features of grains from surging glaciers are also breakage blocks of >10μm, which depend of the phase of separation of the grain from the rock or on thermal changes in the glacier’s foreland.

  8. Community health facility preparedness for a cholera surge in Haiti. (United States)

    Mobula, Linda Meta; Jacquet, Gabrielle A; Weinhauer, Kristin; Alcidas, Gladys; Thomas, Hans-Muller; Burnham, Gilbert


    With increasing population displacement and worsening water insecurity after the 2010 earthquake, Haiti experienced a large cholera outbreak. Our goal was to evaluate the strengths and weaknesses of seven community health facilities' ability to respond to a surge in cholera cases. Since 2010, Catholic Relief Services (CRS) with a number of public and private donors has been working with seven health facilities in an effort to reduce morbidity and mortality from cholera infection. In November 2012, CRS through the Centers for Disease Control and Prevention (CDC)'s support, asked the Johns Hopkins Center for Refugee and Disaster Response to conduct a cholera surge simulation tabletop exercise at these health facilities to improve each facility's response in the event of a cholera surge. Using simulation development guidelines from the Pan American Health Organization and others, a simulation scenario script was produced that included situations of differing severity, supply chain, as well as a surge of patients. A total of 119 hospital staff from seven sites participated in the simulation exercise including community health workers, clinicians, managers, pharmacists, cleaners, and security guards. Clinics that had challenges during the simulated clinical care of patients were those that did not appropriately treat all cholera patients according to protocol, particularly those that were vulnerable, those that would need additional staff to properly treat patients during a surge of cholera, and those that required a better inventory of supplies. Simulation-based activities have the potential to identify healthcare delivery system vulnerabilities that are amenable to intervention prior to a cholera surge.

  9. Wave-Tide-Surge Coupled Simulation for Typhoon Maemi

    Institute of Scientific and Technical Information of China (English)

    Byung Ho Choi; Byung Il Min; Kyeong Ok Kim; Jin Hee Yuk


    The main task of this study focuses on studying the effect of wave-current interaction on currents,storm surge and wind wave as well as effects of current induced wave refraction and current on waves by using numerical models which consider the bottom boundary layer and sea surface roughness parameter for shallow and smooth bed area around Korean Peninsula.The coupled system (unstructured-mesh SWAN wave and ADCIRC) run on the same unstructured mesh.This identical and homogeneous mesh allows the physics of wave-circulation interactions to be correctly resolved in both models.The unstructured mesh can be applied to a large domain allowing all energy from deep to shallow waters to be seamlessly followed.There is no nesting or overlapping of structured wave meshes,and no interpolation is required.In response to typhoon Maemi (2003),all model components were validated independently,and shown to provide a faithful representation of the system's response to this storm.The waves and storm surge were allowed to develop on the continental shelf and interact with the complex nearshore environment.The resulting modeling system can be used extensively for prediction of the typhoon surge.The result show that it is important to incorporate the wave-current interaction effect into coastal area in the wave-tide-surge coupled model.At the same time,it should consider effects of depth-induced wave breaking,wind field,currents and sea surface elevation in prediction of waves.Specially,we found that:(1) wave radiation stress enhanced the current and surge elevation otherwise wave enhanced nonlinear bottom boundary layer decreased that,(2) wind wave was significantly controlled by sea surface roughness thus we cautiously took the experimental expression.The resulting modeling system can be used for hindcasting (prediction) the wave-tide-surge coupled environments at complex coastline,shallow water and fine sediment area like areas around Korean Peninsula.

  10. Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia. (United States)

    Shamma, Rehab Nabil; Aburahma, Mona Hassan


    Spironolactone (SL) is a US Food and Drug Administration-approved drug for the treatment of hypertension and various edematous conditions. SL has gained a lot of attention for treating androgenic alopecia due to its potent antiandrogenic properties. Recently, there has been growing interest for follicular targeting of drug molecules for treatment of hair and scalp disorders using nanocolloidal lipid-based delivery systems to minimize unnecessary systemic side effects associated with oral drug administration. Accordingly, the objective of this study is to improve SL efficiency and safety in treating alopecia through the preparation of colloidal nanostructured lipid carriers (NLCs) for follicular drug delivery. SL-loaded NLCs were prepared by an emulsion solvent diffusion and evaporation method using 23 full factorial design. All of the prepared formulations were spherical in shape with nanometric size range (215.6-834.3 nm) and entrapment efficiency >74%. Differential scanning calorimetry thermograms and X-ray diffractograms revealed that SL exists in amorphous form within the NLC matrices. The drug release behavior from the NLCs displayed an initial burst release phase followed by sustained release of SL. Confocal laser scanning microscopy confirmed the potential of delivering the fluorolabeled NLCs within the follicles, suggesting the possibility of using SL-loaded NLCs for localized delivery of SL into the scalp hair follicles.

  11. Plasma steroid hormone concentrations and blood flow of the ovarian structures of the female dromedary (Camelus dromedarius) during growth, dominance, spontaneous ovulation, luteinization and regression of the follicular wave. (United States)

    Rawy, M S; Derar, R I; El-Sherry, T M; Megahed, G A


    The objectives of this study were to investigate the ovarian follicular waves and their corresponding hormonal changes in she-camels and to elucidate blood perfusion of the ovarian structures. Three reproductively sound, non-pregnant female camels were examined daily using B-mode and color Doppler to detect changes in their ovarian structures and blood vasculature for 22 follicular waves. Blood area (BA) and percentage (BA%) were determined for the ovarian structures. Three phases of follicular development, those of growth, maturation, and regression, were observed during each follicular wave. Deviation occurred on Day 6.1±1.08. Estradiol increased from basal levels of 27.4±0.4pg/ml to peak concentrations of 134.4±47.5pg/ml as the follicle reached a diameter of 13.2mm. Peripheral progesterone concentrations remained low (dromedaries consists of individually variable periods of growth, maturation and regression. Deviation occurs 6.1±1.08d from emergence. Transrectal color-Doppler sonography is a useful technique for noninvasive evaluation of follicular vascularity in camels during various stages of the follicular wave. It provides additional information to assess the developmental stage and activity of the ovarian structures.

  12. Nonlinear chaotic model for predicting storm surges

    NARCIS (Netherlands)

    Siek, M.; Solomatine, D.P.

    This paper addresses the use of the methods of nonlinear dynamics and chaos theory for building a predictive chaotic model from time series. The chaotic model predictions are made by the adaptive local models based on the dynamical neighbors found in the reconstructed phase space of the observables.

  13. Into the Surge of Network-driven Innovation

    DEFF Research Database (Denmark)

    Østergaard, Claus Møller; Rosenstand, Claus Andreas Foss; Gertsen, Frank


    The ambition of this paper is to provide a better theoretical understanding of innovation by framing it in a long historical, economical, and societal perspective. The research question of the paper is: What characterize the historical surges of innovation? Based on previous works and research...... this is examined from the 1880’s up until today. The contribution of the paper is a societal perspective on innovation, where the difference between industrial society and knowledge society leads into the surge of network-driven innovation. Network-driven innovation is unfolded on top of the known cost- driven...

  14. Probabilistic Storm Surge Hazard Assessment in the French West Indies (United States)

    Krien, Y.; Dudon, B.; Roger, J.; Zahibo, N.; Arnaud, G.


    The French West Indies are prone to hurricanes formed over the warm tropical waters of the Atlantic Ocean and Caribbean Sea. These events can have great consequences in terms of human, property, and economic losses. Storm surge hazard assessment is therefore required to provide guidance to emergency managers and decision-makers. By combining statistical-deterministic approaches and wave-current coupled models, we assessed storm surge hazard in Guadeloupe and Martinique islands. We present here the methodology, the results, as well as the on-going work on the impact of climate change in the framework of the FEDER-funded project C3AF.

  15. A High Resolution Forecast Model of Storm Surge Inundation

    Institute of Scientific and Technical Information of China (English)

    LIU Juan; JIANG Wensheng; SUN Wenxin; WANG Yongzhi


    In order to forecast storm surge inundation, a two-dimensional model is established. In the model, an alternating computation sequence method is used to solve the governing equations, and the dry and wet method is introduced to treat the moving boundary. This model is easy to use. It has a friendly input interface and Arcview GIS is used as the output interface. The model is applied to the Shantou area to simulate the storm surge elevations and inundations caused by Typhoons 6903 ane 0104 using the same relevant parameters. The calculated results agree well with the observations.

  16. Surge of the Bivachny Glacier in 2012–2015


    V. M. Kotlyakov; L. V. Desinov; V. A. Rudakov


    The surge of the Bivachny Glacier that occurred in 2012–2015 is analyzed with the use of photographing performed from International Space Station in 2001–2015 together with data of the satellite monitoring of 1972–2000. This surge happened in 31 years after the similar previous event of 1972–1976. Dynamics of numerous glacier branches causing activation of the lower glacier part that is so called “dead” zone (more than 7 km in length) is shown. Just before its stop the front part of the surgi...

  17. Geological Controls on Glacier Surging?: Statistics and Speculation (United States)

    Flowers, G. E.; Crompton, J. W.


    Glacier surging represents an end-member behavior in the spectrum of ice dynamics, involving marked acceleration and high flow speeds due to abrupt changes in basal mechanics. Though much effort has been devoted to understanding the role of basal hydrology and thermal regime in fast glacier flow, fewer studies have addressed the potential role of the geologic substrate. One interesting observation is that surge-type glaciers appear almost universally associated with unconsolidated (till) beds, and several large-scale statistical studies have revealed correlations between glacier surging and bedrock properties. We revisit this relationship using field measurements. We selected 20 individual glaciers for sampling in a 40x40 km region of the St. Elias Mountains of Yukon, Canada. Eleven of these glaciers are known to surge and nine are not. The 20 study glaciers are underlain by lithologies that we have broadly classified into two types: metasedimentary only and mixed metasedimentary-granodiorite. We characterized geological and geotechnical properties of the bedrock in each basin, and analyzed the hydrochemistry and mineralogy and grain size distribution (GSD) of the suspended sediments in the proglacial streams. Here we focus on some intriguing results of the GSD analysis. Using statistical techniques, including significance testing and principal component analysis, we find that: (1) lithology determines GSD for non-surge-type glaciers, with metasedimentary basins associated with finer mean grain sizes and mixed-lithology basins with coarser mean grain sizes, but (2) the GSDs associated with surge-type glaciers are intermediate between the distributions described above, and are statistically indistinguishable between metasedimentary and mixed lithology basins. The latter suggests either that surge-type glaciers in our study area occur preferentially in basins where various processes conspire to produce a characteristic GSD, or that the surge cycle itself exerts an


    Institute of Scientific and Technical Information of China (English)

    尹宝树; 侯一筠; 程明华; 苏京志; 林明祥; 李明悝; M.I.El-Sabh


    Abstract The author's combined numerical model consisting of a third generation shallow water wave model and a 3-D tide-surge model with wave-dependent surface wind stress were used to study the influence of waves on fide-surge motion. For the typical weather case, in this study, the magnitude and mechanism of the influence of waves on tide-surges in the Bohai Sea were revealed for the first time. The results showed that although consideration of the wave-dependent surface wind stresses raise slightly the traditional surface wind stress, due to the accumulated effects, the computed results are improved on the whole. Storm level maximum modulation can reach 0.4 m. The results computed by the combined model agreed well with the measured data.


    Institute of Scientific and Technical Information of China (English)


    The author's combined numerical model consisting of a third generation shallow water wave model and a 3-D tide-surge model with wave-dependent surface wind stress were used to study the influence of waves on tide-surge motion. For the typical weather case, in this study, the magnitude and mechanism of the influence of waves on tide-surges in the Bohai Sea were revealed for the first time. The results showed that although consideration of the wave-dependent surface wind stresses raise slightly the traditional surface wind stress, due to the accumulated effects, the computed results are improved on the whole. Storm level maximum modulation can reach 0.4 m. The results computed by the combined model agreed well with the measured data.

  20. Numerical modeling of storm surges in the coast of Mozambique: the cases of tropical cyclones Bonita (1996) and Lisette (1997) (United States)

    Bié, Alberto José; de Camargo, Ricardo; Mavume, Alberto Francisco; Harari, Joseph


    The coast of Mozambique is often affected by storms, particularly tropical cyclones during summer or sometimes midlatitude systems in the southern part. Storm surges combined with high freshwater discharge can drive huge coastal floods, affecting both urban and rural areas. To improve the knowledge about the impact of storm surges in the coast of Mozambique, this study presents the first attempt to model this phenomenon through the implementation of the Princeton Ocean Model (POM) in the Southwestern Indian Ocean domain (SWIO; 2-32°S, 28-85°E) using a regular grid with 1/6° of spatial resolution and 36 sigma levels. The simulation was performed for the period 1979-2010, and the most interesting events of surges were related to tropical cyclones Bonita (1996) and Lisette (1997) that occurred in the Mozambique Channel. The results showed that the model represented well the amplitude and phase of principal lunar and solar tidal constituents, as well as it captured the spatial pattern and magnitudes of SST with slight positive bias in summer and negative bias in winter months. In terms of SSH, the model underestimated the presence of mesoscale eddies, mainly in the Mozambique Channel. Our results also showed that the atmospheric sea level pressure had a significant contribution to storm heights during the landfall of the tropical cyclones Bonita (1996) and Lisette (1997) in the coast of Mozambique contributing with about 20 and 16% of the total surge height for each case, respectively, surpassing the contribution of the tide-surge nonlinear interactions by a factor of 2.

  1. Aging assessment of surge protective devices in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Davis, J.F.; Subudhi, M. [Brookhaven National Lab., Upton, NY (United States); Carroll, D.P. [Florida Univ., Gainesville, FL (United States)


    An assessment was performed to determine the effects of aging on the performance and availability of surge protective devices (SPDs), used in electrical power and control systems in nuclear power plants. Although SPDs have not been classified as safety-related, they are risk-important because they can minimize the initiating event frequencies associated with loss of offsite power and reactor trips. Conversely, their failure due to age might cause some of those initiating events, e.g., through short circuit failure modes, or by allowing deterioration of the safety-related component(s) they are protecting from overvoltages, perhaps preventing a reactor trip, from an open circuit failure mode. From the data evaluated during 1980--1994, it was found that failures of surge arresters and suppressers by short circuits were neither a significant risk nor safety concern, and there were no failures of surge suppressers preventing a reactor trip. Simulations, using the ElectroMagnetic Transients Program (EMTP) were performed to determine the adequacy of high voltage surge arresters.

  2. Why Teen Mental Ability Surges While Brain Shrinks (United States)

    ... Why Teen Mental Ability Surges While Brain Shrinks Researchers say they may have answer to ... behavior keep scaling up," he said. So while teens lose brain volume and girls have lower brain volume than ...

  3. 14 CFR 33.65 - Surge and stall characteristics. (United States)


    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Surge and stall characteristics. 33.65 Section 33.65 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... stall characteristics. When the engine is operated in accordance with operating instructions required...

  4. Monitoring Inland Storm Surge and Flooding from Hurricane Rita (United States)

    McGee, Benton D.; Tollett, Roland W.; Mason, Jr., Robert R.


    Pressure transducers (sensors) and high-water marks were used to document the inland water levels related to storm surge generated by Hurricane Rita in southwestern Louisiana and southeastern Texas. On September 22-23, 2005, an experimental monitoring network of sensors was deployed at 33 sites over an area of about 4,000 square miles to record the timing, extent, and magnitude of inland hurricane storm surge and coastal flooding. Sensors were programmed to record date and time, temperature, and barometric or water pressure. Water pressure was corrected for changes in barometric pressure and salinity. Elevation surveys using global-positioning systems and differential levels were used to relate all storm-surge water-level data, reference marks, benchmarks, sensor measuring points, and high-water marks to the North American Vertical Datum of 1988 (NAVD 88). The resulting data indicated that storm-surge water levels over 14 feet above NAVD 88 occurred at three locations, and rates of water-level rise greater than 5 feet per hour occurred at three locations near the Louisiana coast.

  5. ISSN 2073-9990 East Cent. Afr. J. surg

    African Journals Online (AJOL)

    Hp 630 Dual Core

    COSECSA/ASEA Publication - East and Central African Journal of Surgery. December 2016; Vol. .... shorter duration (median of 20 weeks vs. 3.5 weeks, p 0.029). .... inguinal hernia in children: laparoscopic or open? Eur J Ped Surg 2011; 21: ...

  6. On the Response of Interleaved Transformer Windings to Surge Voltages

    DEFF Research Database (Denmark)

    Pedersen, A.


    The high series capacitance theory for the response of interleaved transformer windings to surge voltages is criticized from the point of view that an increased series capacitance as a result of interleaving is incompatible with the concept of a pure capacitive initial voltage distribution. A new...

  7. The Surge of Micro-computers (United States)

    Morita, Written By Ichiko; Matsumura, Translated By Tamiko

    Libraries in the United States are now experiencing another phase of rapid change brought by the sudden invasion of micro-computers. Their versatility has made available not only capabilities for word processing and producing spread sheets but also introduced new approaches to large research libraries’ information networks. OCLC’s microenhancers are one example of what is now available. They can be used for retrospective conversion, provide instruction for the use of and function as front end terminals for large online catalogs. Various new ideas for the application of micro-computers will bring interesting developments in library automation.

  8. Skin fragility syndrome in a cat with multicentric follicular lymphoma. (United States)

    Crosaz, Odile; Vilaplana-Grosso, Federico; Alleaume, Charline; Cordonnier, Nathalie; Bedu-Leperlier, Anne-Sophie; Marignac, Geneviève; Hubert, Blaise; Rosenberg, Dan


    An 11-year-old, spayed female domestic shorthair cat was presented for a right flank wound. On clinical examination, a single non-painful skin tear lesion with irregular edges was detected. During the examination, star-shaped cigarette paper-like skin lesions appeared spontaneously. An abdominal mass was also palpated. Feline skin fragility syndrome (FSFS) was suspected and a multicentric lymphoma was diagnosed by fine needle aspiration. The cat's condition declined and it died spontaneously. Post-mortem examination confirmed the diagnosis of lymphoma. Neoplastic lymphocytes were not observed in the skin. Histological analysis of the skin was consistent with the morphological aspects of FSFS. A possible direct link between the two conditions remains a matter of speculation, but this case report provides the first description of FSFS associated with multicentric follicular lymphoma. Thus, multicentric follicular lymphoma should be considered as a differential diagnosis in cats presenting with FSFS.

  9. New drugs for follicular lymphoma in older adults. (United States)

    Schmitt, Anna; Soubeyran, Pierre


    Follicular lymphoma is essentially a disease of the elderly, and the aging of the population in developed countries will increase patient numbers in coming years. Significant achievements have been made for treatment, but better understanding of the disease and major progress in biology now facilitate the development of many new drugs, which may have improved toxicity profiles making them appropriate for treatment of older adults. However, the increasing number of treatment possibilities, can also increase the toxicity risks, and unexpected toxicities specific to older adults may be encountered. Consequently, specific studies of older patients should be considered, using appropriate evaluation tools such as comprehensive geriatric assessment. This review will described the development of these new drugs, in the context of the treatment of older-adults with follicular lymphoma.

  10. Two cases of extranodal follicular dendritic cell sarcoma

    Institute of Scientific and Technical Information of China (English)

    王坚; 孔蕴仪; 陆洪芬; 许越香


    @@ Follicular dendritic cell (FDC) is an essential component of the nonlymphoid, nonphagocytic immunoaccessory reticulum cells of the peripheral lymphoid tissue.1 Follicular dendritic cell sarcoma (FDCs) are confined largely to the primary and secondary B-cell follicles, where they form a tight interlacing meshwork. They play a role in the capture and presentation of antigens, generation and regulation of immune complexes. FDCs can be recognized morphologically by their indistinct cellular borders, pale eosinophilic cytoplasm, round-to-ovoid nuclei with delicate nuclear membranes and clear-to-vesicular chromatin with inconspicuous or small nucleoli. FDCs are best identified through immunostaining using CD21, CD35, R4/23, KiM4, KiM4p and Ki-FDC1p.


    Directory of Open Access Journals (Sweden)

    Agung Warsito


    Full Text Available Electric energy has been transmiting from power station to end user with transmission and distribution lines.Lightning strokes are problems that occure in transmission and distribution lines and make them fault when theelectric energy were transmited. Surge Diverter or Lightning Arrester has been installing to reduce these faults.In this paper the simulation of lightning stroke and lightning arrester performance on distribution lines 20 kVwere done using EMTP (Electromagnetic Transient Program. Some parameters such us impuls voltage andincreasing voltage on distribution line was inverstigated. As case study in this simulation, Mojosongo 1 mainfeeder 20 kV three phase lines were used.The simulation results show that the lightning stroke 20 kA in By1-61-61E-84-9I on S phase at 0,1 ms, makevoltage on S phase was increased about 1,3054 MV. For R phase and T phase will increase of induced voltagewere 0.79539 MV and 0.80484 MV. We also show the performance of MOV Arrester (Metal Oxide Varistor inovercoming lightning stroke trouble, where arrester can decrease voltage up to 15.198 kV on S phase, while atR phase and T phase arrester can decrease voltage up to 11.375 kV and 13.616 kV.

  12. Changing the guard: Polymer replaces porcelain for surge arresters

    Energy Technology Data Exchange (ETDEWEB)

    Skytt, T.; Gleimar, H. E. G.


    Surge arresters are safety devices which quickly and effectively limit the over voltages that can arise in transmission networks following lightning, switching and other transient events. The earliest forms of overvoltage protection, a simple air gap between electrodes, have long since been replaced by a new generation of gapless arresters with series-connected, non-linear zinc oxide varistors contained in a porcelain housing. Now these porcelain type surge arresters are being replaced by a new type, called PEXLIM (Polymeric EXcellent LIMiter), which uses the same block of zinc oxide as the porcelain type, but its housing is made of silicon rubber, a polymer. The new lightweight insulation material shows a number of properties superior to the porcelain, such as enhanced product safety and ease of handling. It is also more durable, resilient, yet solid and compact, water-repellent, lightweight, resistant to aging or light or ultra-violet radiation, as well as fire, has good electrical properties, and is environmentally friendly since it does not contain any substances harmful to the environment. These properties make this new type of surge arrester highly suitable for use in earthquake-prone areas; it can also replace more expensive and maintenance-intensive equipment. Having successfully broken into the lower voltage systems, these new type of surge arresters are now rapidly gaining ground at the higher voltage levels. ABB, the developer of PEXLIM, has already supplied these arresters to North America for use in an 800-kV grid. As further proof of its growing popularity, last year PEXLIM made up over half of the surge arrester production for applications up to and including 245 kV. 1 tab., 6 figs.

  13. A basis function approach for exploring the seasonal and spatial features of storm surge events (United States)

    Wu, Wenyan; Westra, Seth; Leonard, Michael


    Storm surge is a significant contributor to flooding in coastal and estuarine regions. To represent the statistical characteristics of storm surge over a climatologically diverse region, we propose the use of basis functions that capture the temporal progression of individual storm surge events. This extends statistical analyses of surge from considering only the peak to a more multifaceted approach that also includes decay rate and duration. Our results show that there is seasonal variation in storm surge along the Australian coastline. During the dominant storm surge seasons, the peak and duration of storm surge events tend to increase simultaneously at a number of locations, with implications for flood damage assessments and evacuation planning. By combining the dynamic and statistical features of storm surge, it is possible to better understand the factors that can lead to flood risk along the coastline, including estuarine areas that are also affected by fluvial floods.

  14. Storm surge in the Bay of Bengal and Arabian Sea: The problem and its prediction

    Digital Repository Service at National Institute of Oceanography (India)

    Dube, S.K.; Rao, A.D.; Sinha, P.C.; Murty, T.S.; Bahulayan, N.

    India and its neighbourhood is threatened by the possibility of storm surge floods whenever a tropical cyclone approaches. Storm surge disasters cause heavy loss of life and property, damage to the coastal structures and agriculture nwhich lead...

  15. Mandibular metastasis of follicular thyroid carcinoma. Case report. (United States)

    Ostrosky, Alejandro; Mareso, Eduardo Arístides; Klurfan, Federico Juan; Gonzalez, Maximiliano Jorge


    Thyroid carcinoma mandibular metastasis are not very frequent and the cases described in literature are few. Due to its bloodstream dissemination, most of them are a consequence of the follicular variant of thyroid carcinomas. A case is presented and a review of the clinicopathologic characteristics of the lesion is made, so the oral and maxilofacial surgeon can recognize it, make a correct differential diagnosis with other mandibular radioluciencies and in consequence, carry out an adequate treatment.

  16. Plasma cells negatively regulate the follicular helper T cell program



    B lymphocytes differentiate into antibody-secreting cells under the antigen-specific control of follicular helper T (TFH) cells. Here, we demonstrate that isotype-switched plasma cells expressed MHCII, CD80 and CD86 and intracellular machinery required for antigen presentation. Antigen-specific plasma cells could access, process and present sufficient antigen in vivo to induce multiple TH cell functions. Importantly, antigen-primed plasma cells failed to induce interleukin 21 or Bcl-6 in naïv...

  17. Direct hair transplantation: A modified follicular unit extraction technique

    Directory of Open Access Journals (Sweden)

    Pradeep Sethi


    Full Text Available Background: In hair transplantation, the survival rate of harvested grafts depends upon many factors like maintenance of hydration, cold temperature, reduced mechanical handling and asepsis. All these factors are favourably improved if time out of body is reduced significantly. We have tried a modification called direct hair transplantation in the existing follicular unit extraction technique, in which the follicular unit grafts are implanted as soon as they are harvested. In this article, we have described the detailed methodology and a series of 29 patients who underwent direct hair transplantation. Aim: To evaluate the efficacy and feasibility of direct hair transplantation. Subjects and Methods: The patients willing to undergo hair transplantation by the technique of follicular unit extraction were enrolled for the surgery. After administration of local anaesthesia, the recipient sites were created. Thereafter, the processes of scoring the skin with a motorized punch, graft extraction and implantation were performed simultaneously. These patients were followed up to look for the time period of initiation of hair growth, the growth achieved at the end of 6-8 months and any adverse events. The results of patients with noticeable improvement in the photographs and reduction in baldness grade were taken as ′good′, whereas, in other patients, it was classified as ′poor′. Results: All patients were males with age ranging from 21 to 66 years (median 30 years. Twenty-six patients had androgenetic alopecia, 1 patient had traction alopecia and 2 patients had scarring alopecia. Twenty-seven patients showed ′good′ results, whereas 2 patients showed ′poor′ results. Conclusion: Direct hair transplantation is a simple and feasible modification in the follicular unit extraction technique. It is an efficacious surgical treatment modality for baldness.

  18. Pathologic splenic rupture in a patient with follicular lymphoma

    Directory of Open Access Journals (Sweden)

    Manoranjan Mahapatra


    Full Text Available Follicular lymphoma (FL is the most common indolent Non Hodgkin’s lymphoma (NHL . It presents primarily with widespread disease which may be asymptomatic and involves the bone marrow in around 40% of patients . Although the disease is widespread at presentation the incidence of complications such as splenic rupture which are usually seen with other aggressive lymphomas is rare

  19. A modeling study of coastal inundation induced by storm surge, sea-level rise, and subsidence in the Gulf of Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Zhaoqing; Wang, Taiping; Leung, Lai-Yung R.; Hibbard, Kathleen A.; Janetos, Anthony C.; Kraucunas, Ian P.; Rice, Jennie S.; Preston, Benjamin; Wilbanks, Thomas


    The northern coasts of the Gulf of Mexico are highly vulnerable to the direct threats of climate change, such as hurricane-induced storm surge, and such risks can be potentially exacerbated by land subsidence and global sea level rise. This paper presents an application of a coastal storm surge model to study the coastal inundation process induced by tide and storm surge, and its response to the effects of land subsidence and sea level rise in the northern Gulf coast. An unstructured-grid Finite Volume Coastal Ocean Model was used to simulate tides and hurricane-induced storm surges in the Gulf of Mexico. Simulated distributions of co-amplitude and co-phase of semi-diurnal and diurnal tides are in good agreement with previous modeling studies. The storm surges induced by four historical hurricanes (Rita, Katrina, Ivan and Dolly) were simulated and compared to observed water levels at National Oceanic and Atmospheric Administration tide stations. Effects of coastal subsidence and future global sea level rise on coastal inundation in the Louisiana coast were evaluated using a parameter “change of inundation depth” through sensitivity simulations that were based on a projected future subsidence scenario and 1-m global sea level rise by the end of the century. Model results suggested that hurricane-induced storm surge height and coastal inundation could be exacerbated by future global sea level rise and subsidence, and that responses of storm surge and coastal inundation to the effects of sea level rise and subsidence are highly nonlinear and vary on temporal and spatial scales.

  20. Challenges in Downscaling Surge and Flooding Predictions Associated with Major Coastal Storm Events (United States)

    Bowman, M. J.


    Coastal zone managers, elected officials and emergency planning personnel are continually seeking more reliable estimates of storm surge and inundation for better land use planning, the design, construction and operation of coastal defense systems, resilience evaluation and evacuation planning. Customers of modern regional weather and storm surge prediction models demand high resolution, speed, accuracy, with informative, interactive graphics and easy evaluation of potentially dangerous threats to life and property. These challenges continue to get more difficult as the demand for street-scale and even building-scale predictions increase. Fluctuations in sub-grid-scale wind and water velocities can lead to unsuspected, unanticipated and dangerous flooding in local communities. But how reliable and believable are these models given the inherent natural uncertainty and chaotic behavior in the underlying dynamics, which can lead to rapid and unexpected perturbations in the wind and pressure fields and hence coastal flooding? Traditionally this uncertainty has been quantified by the use of the ensemble method, where a suite of model runs are made with varying physics and initial conditions, presenting the mean and variance of the ensemble as the best metrics possible. But this assumes that each component is equally possible and is statistically independent of the others. But this is rarely true, although the "safety in numbers" approach is comforting to those faced with life and death decisions. An example of the ensemble method is presented for the trajectory of superstorm Sandy's storm center as it approached coastal New Jersey. If one were to ask the question "was Sandy a worst case scenario", the answer would be "no: small variations in the timing (vis-à-vis tide phase) and location of landfall could easily have led to an additional surge of +50 cm at The Battery NY with even more catastrophic consequences to those experienced".

  1. Nutritional and lactational effects on follicular development in the pig. (United States)

    Quesnel, H


    In sows, follicular development is inhibited during lactation, and weaning the piglets allows recruitment and selection of follicles that will undergo preovulatory maturation and ovulate. Lactation inhibits GnRH secretion, and in turn LH secretion, through neuroendocrine stimuli induced by suckling. Pituitary response to GnRH and the sensitivity of the hypothalamo-pituitary unit to oestradiol positive feedback are also reduced. The impact of lactation on the reproductive axis is further complicated by the physiological and metabolic adaptations that are developed for milk production and that depend on nutrient intake, nutrient needs and body reserves. A strongly catabolic state during lactation amplifies the inhibition of LH secretion, thereby inducing a delay of oestrus and ovulation after weaning. Nevertheless, post-weaning ovulation is less delayed nowadays than in the 1970's or 80's. Nutritional deficiency has also deleterious effects on embryo survival, which are likely related to alterations in follicular growth and maturation. The physiological mechanisms by which information on the metabolic changes is transmitted to the hypothalamus-pituitary-ovary axis are not fully understood in the sow. Glucose, insulin and leptin are the most likely signals informing the hypothalamus of the metabolic state, yet their roles have not been definitely established. At the ovarian level, folliculogenesis is likely to be altered by the reduction in insulin and IGF-I concentrations induced by nutritional deficiency. More knowledge is needed at the intrafollicular level to better understand nutritional effects on follicular development, and also on occyte quality and embryo development.

  2. How T cells earn the follicular rite of passage. (United States)

    Vinuesa, Carola G; Cyster, Jason G


    The discovery that Bcl-6 was the transcriptional regulator of follicular helper T (Tfh) cells completed the recognition of this population as an effector subset specialized in the provision of help to B cells. Improved reagents and recent models that allow tracking of Bcl-6-expressing T cells have revealed that the decision to become a Tfh cell occurs soon after T cells are primed by dendritic cells and start dividing, before interaction with B cells. The latter are important for sustaining Bcl-6 expression. Bcl-6 coordinates a signaling program that changes expression or function of multiple guidance receptors, leading to Tfh cell localization within germinal centers. This program is not unique to CD4(+) helper T cells; FoxP3(+) regulatory T cells and NKT cells co-opt the follicular differentiation pathway to enter the follicle and become specialized follicular cells. This review will focus on recent insights into the early events that determine Tfh cell differentiation. Copyright © 2011 Elsevier Inc. All rights reserved.

  3. Stress induced alterations in pre-pubertal ovarian follicular development in rat

    Directory of Open Access Journals (Sweden)

    Yajurvedi H.N.


    Full Text Available The objective of the study was to find out whether stress experienced during neo-natal period alters the timing of formation of pre-antral and antral follicles and if so, whether pre-treatment with CRH receptor antagonist prevents these effects in rats. New born rat pups (n= 15 were exposed to maternal separation (6 hours/ day from post-natal day (PND 1 to 7 and were killed on PND 8, 11 and 15. The time of exposure was randomly changed every day during light phase (7Am to 7Pm of the day to avoid habituation. There was a significant increase in serum corticosterone levels on PND 8 and 11 in stress group rats compared to controls indicating stress response in these pups. The ovary of both control and stressed rats contained oocytes and primary follicles on PND 8 and 11 and in showed progress of follicular development upto to pre-antral and early antral follicle formation on PND 11 and 15. However, mean number of healthy oocytes and all categories of follicles at all ages studied were significantly lower in stressed rats compared to controls. Concomitant with these changes, number of atreatic follicles showed an increase over control values in stressed rats. The increase in atresia of follicles was due to apoptosis as shown by increase in the percentage of granulosa cells showing TUNEL positive staining and caspase 3 activity. On the other hand, pre-treatment with CRH- receptor antagonist (CRH 9-41 2ng/ 0.1 ml/ rat prior to undergoing stress regime on PND 1 to 7, prevented alterations in pre- pubertal follicular development thereby indicating that the ovarian changes were due to effects of stress induced activation of HPA axis. The results indicate that, stress during neonatal phase, though does not affect timing of formation of pre-antral and antral follicles, it does enhance atresia of follicles of all categories, including follicular reserve, which may affect the reproductive potential of adults. The results, for the first time reveal that CRF

  4. Effect of Coupling Wave and Flow Dynamics on Hurricane Surge and Inundation (United States)


    impacted hurricanes - both by the wind fields as well as by the accompanying surge. Forecasting the extent of the inundation is critical for local...estimate local surge hazards; and in the other, ensemble model runs are used to determine surge values from a set of parameterized storms [Irish et...with the storm surge to create the storm tide. The extent of coastal inundation - flooding of inland surface that is not normally submerged, is

  5. Brief Communication: On the magnitude and frequency of Khurdopin glacier surge events


    D. J. Quincey; Luckman, A.


    The return periods of Karakoram glacier surges are poorly quantified. Here, we present evidence of an historic surge of the Khurdopin Glacier that began in the mid-1970s and peaked in 1979. Measured surface displacements reached >5 km a−1, two orders of magnitude faster than during quiescence. The Khurdopin Glacier next surged in the late 1990s, equating to a return period of 20 years. Surge evolution in the two events shows remarkable similarity suggesting a common trigger....

  6. Dynamic behavior of the Bering Glacier-Bagley icefield system during a surge, and other measurements of Alaskan glaciers with ERS SAR imagery (United States)

    Lingle, Craig S.; Fatland, Dennis R.; Voronina, Vera A.; Ahlnaes, Kristina; Troshina, Elena N.


    ERS-1 synthetic aperture radar (SAR) imagery was employed for the measurement of the dynamics of the Bagley icefield during a major surge in 1993-1994, the measurement of ice velocities on the Malaspina piedmont glacier during a quiescent phase between surges, and for mapping the snow lines and the position of the terminus of Nabesna glacier on Mount Wrangell (a 4317 m andesitic shield volcano) in the heavily glacierized Saint Elias and Wrangell Mountains of Alaska. An overview and summary of results is given. The methods used include interferometry, cross-correlation of sequential images, and digitization of boundaries using terrain-corrected SAR imagery.

  7. 30 CFR 57.16002 - Bins, hoppers, silos, tanks, and surge piles. (United States)


    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Bins, hoppers, silos, tanks, and surge piles... NONMETAL MINES Materials Storage and Handling § 57.16002 Bins, hoppers, silos, tanks, and surge piles. (a) Bins, hoppers, silos, tanks, and surge piles, where loose unconsolidated materials are stored,...

  8. 30 CFR 56.16002 - Bins, hoppers, silos, tanks, and surge piles. (United States)


    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Bins, hoppers, silos, tanks, and surge piles... MINES Materials Storage and Handling § 56.16002 Bins, hoppers, silos, tanks, and surge piles. (a) Bins, hoppers, silos, tanks, and surge piles, where loose unconsolidated materials are stored, handled...


    Institute of Scientific and Technical Information of China (English)

    王喜富; 张幼蒂; 张达贤


    Based on the function analysis of surge bunker in mine haulage system, the authors raise the calculation methods of the total output of a mine haulage system. Taking the maximum of system's total throughput as a objective, the method of determining the surge bunker's rational size is put forward. Also, the problems of rational position of surge bunker are analysesed.

  10. A model study of Abrahamsenbreen, a surging glacier in northern Spitsbergen

    NARCIS (Netherlands)

    Oerlemans, J.; van Pelt, W. J. J.


    The climate sensitivity of Abrahamsenbreen, a 20 km long surge-type glacier in northern Spitsbergen, is studied with a simple glacier model. A scheme to describe the surges is included, which makes it possible to account for the effect of surges on the total mass budget of the glacier. A climate rec

  11. Characterization of intratumoral follicular helper T cells in follicular lymphoma: role in the survival of malignant B cells (United States)

    Amé-Thomas, Patricia; Le Priol, Jérôme; Yssel, Hans; Caron, Gersende; Pangault, Céline; Jean, Rachel; Martin, Nadine; Marafioti, Teresa; Gaulard, Philippe; Lamy, Thierry; Fest, Thierry; Semana, Gilbert; Tarte, Karin


    Accumulating evidences indicate that the cellular and molecular microenvironment of follicular lymphoma (FL) plays a key role in both lymphomagenesis and patient outcome. Malignant FL B cells are found admixed to specific stromal and immune cell subsets, in particular CD4pos T cells displaying phenotypic features of follicular helper T cells (TFH). The goal of our study was to functionally characterize intratumoral CD4pos T cells. We showed that CXCR5hiICOShiCD4pos T cells sorted from FL biopsies comprise at least two separate cell populations with distinct genetic and functional features: i) CD25pos follicular regulatory T cells (TFR), and ii) CD25neg TFH displaying a FL-B cell supportive activity without regulatory functions. Furthermore, despite their strong similarities with tonsil-derived TFH, purified FL-derived TFH displayed a specific gene expression profile including an overexpression of several genes potentially involved directly or indirectly in lymphomagenesis, in particular TNF, LTA, IL4, or CD40LG. Interestingly, we further demonstrated that these two last signals efficiently rescued malignant B cells from spontaneous and Rituximab-induced apoptosis. Altogether, our study demonstrates that tumor-infiltrating CD4pos T cells are more heterogeneous than previously presumed, and underlines for the first time the crucial role of TFH in the complex set of cellular interactions within FL microenvironment. PMID:22015774

  12. Mixed Medullary-follicular Thyroid Carcinoma: Report of a Case and Review of the Literature

    Institute of Scientific and Technical Information of China (English)

    Xiangtao Ma; Liwei Yu; Jing Fu; Shan Wang; Ruyu Du; Zhirong Cui


    @@ Mixed medullary-follicular carcinomas (MMFCs) are tumors of the thyroid that display morphological and immunohistochemical features of both medullary and follicular neoplasms. These tumors are rare and less than 40 cases have been described in the literature since the early 1980s.[1] The term medullary-follicular thyroid carcinoma denotes a tumor which exhibits the features of a medullary carcinoma and shows positive expression of calcitonin on immunohistochemistry.

  13. Building and Analyzing SURGEDAT: The World's Most Comprehensive Storm Surge Database (United States)

    Needham, H.; Keim, B.


    SURGEDAT, the world's most comprehensive tropical storm surge database, has identified and mapped the location and height of hundreds of global storm surge events. This project originated with a study that identified more than 200 tropical surge events along the U.S. Gulf Coast. Spatial analysis of these data reveal that the central and western Gulf Coast observe more frequent and higher magnitude surges, whereas much of the eastern Gulf Coast, including the west coast of Florida, experiences less storm surge activity. Basin-wide return period analysis of these data estimate a 100-year return period of 8.20m, and a 10-year return period of 4.95m. Return period analysis of 10 sub-regions within the basin reveal that the highest surge levels occur in the Southeast Louisiana/ Mississippi zone, which includes the New Orleans metropolitan area. The 100-year surge level in this zone is estimated to be 7.67m. The Southeast Texas/ Southwest Louisiana zone, which includes the Houston metropolitan area, has the second highest surge levels, with a 100-year storm surge estimate of 6.30m. Surge levels are lower on the west coast of Florida, where the 100-year surge level is estimated between three and four meters. Expansion of this work includes mapping all high water marks for each surge event and the creation of a search-by-location web tool, which enables users to see the entire storm surge history for specific locations. In addition, the dataset has expanded internationally and now includes more than 500 surge events, as surges have now been identified in all the major ocean basins that experience tropical cyclones. International partnerships are sought to further expand this work, particularly in Australia, China, Japan, Philippines, India, Bangladesh, Myanmar, Mexico and various countries in Oceania and the Caribbean.; ;

  14. Waves of accelerated motion in a glacier approaching surge: the mini-surges of Variegated Glacier, Alaska, U.S.A.


    Kamb, Barclay; Engelhardt, Hermann


    Periods of dramatically accelerated motion, in which the flow velocity increases suddenly from about 55 cm/d to a peak of 100-300 cm/d and then decreases gradually over the course of a day, occurred repeatedly during June and July 1978-81 in Variegated Glacier (Alaska), a surging-type glacier that surged in 1982-83. These "mini-surges" appear to be related mechanistically to the main surge. The flow-velocity peak propagates down-glacier as a wave at a speed of about 0.3 km/h, over a reach of ...

  15. Actual Incidence and Clinical Behaviour of Follicular Thyroid Carcinoma: An Institutional Experience

    Directory of Open Access Journals (Sweden)

    Carmela De Crea


    Full Text Available Follicular thyroid carcinoma classically accounts for 10–32% of thyroid malignancies. We determined the incidence and the behaviour of follicular thyroid carcinoma in an endemic goitre area. A comparative analysis between minimally invasive and widely invasive follicular thyroid carcinoma was performed. The medical records of all patients who underwent thyroidectomy from October 1998 to April 2012 for thyroid malignancies were reviewed. Those who had a histological diagnosis of follicular carcinoma were included. Among 5203 patients, 130 (2.5% were included. Distant metastases at presentation were observed in four patients. Sixty-six patients had a minimally invasive follicular carcinoma and 64 a widely invasive follicular carcinoma. In 63 patients an oxyphilic variant was registered. Minimally/widely invasive ratio was 41/26 for usual follicular carcinoma and 25/38 for oxyphilic variant (P<0.05. Patients with widely invasive tumors had larger tumors (P<0.001 and more frequently oxyphilic variant (P<0.05 than those with minimally invasive tumours. No significant difference was found between widely invasive and minimally invasive tumors and between usual follicular carcinoma and oxyphilic variant regarding the recurrence rate (P=NS. The incidence of follicular thyroid carcinoma is much lower than classically retained. Aggressive treatment, including total thyroidectomy and radioiodine ablation, should be proposed to all patients.

  16. A level set formulation for the numerical simulation of impact of surge fronts

    Indian Academy of Sciences (India)

    A Salih; S Ghosh Moulic


    In this paper we present a level set-based algorithm for the solution of incompressible two-phase flow problems. The technique is applied to the numerical simulation of impact of two surge fronts resulting from the collapse of liquid columns. The incompressible Navier–Stokes equations are solved using a projection method based on forward Euler time-stepping. The Hamilton–Jacobi type equation for the transport of level set function is carried out by a high resolution fifth-order accurate WENO scheme. For efficient implementation of the WENO scheme we have proposed grid staggering for the level set function. The solution of the pressure Poisson equation is obtained using an efficient preconditioned conjugate gradient method. It is shown that the present formulation works very well for large density and viscosity ratios. For the purpose of validation, we have simulated small-amplitude free sloshing of liquid in a container and the well-known two-dimensional broken-dam problem of Martin and Moyce. Simulations of impact of surge fronts have been carried out and the results are discussed.

  17. On the Non-Monotonic Variation of the Opposition Surge Morphology with Albedo Exhibited by Satellites' Surface (United States)

    Deau, E. A.; Spilker, L. J.; Flandes, A.


    We used well know phase functions of satellites and rings around the giant planets of our Solar System to study the morphology of the opposition effect (at phase angles alpha morphological model to retrieve the morphological parameters of the surge (A and HWHM). These parameters are found to have a non-monotonic variation with the single scattering albedo, similar to that observed in asteroids, which is unexplained so far. The non-monotonic variation is discussed in the framework of the coherent backscattering and shadow hiding mechanisms.

  18. Differential diagnosis of follicular cancer and follicular adenoma using an expert system based on a set of qualitative signs of cell atypia. (United States)

    Kirillov, Vladimir; Emeliyanova, Olga


    To determine the efficiency of the developed expert system based on a set of qualitative signs of cell atypia and their weighting coefficients in the differential diagnosis of follicular cancer and follicular adenoma of the thyroid gland. Sixty cytologic preparations of patients with histologic diagnosis of a follicular cancer and follicular adenoma were investigated. Weighting coefficients for each sign of atypia for both forms of pathology have been calculated with the help of the deduced equation. This allowed creating an expert system by which the function of transforming qualitative signs of cell atypia to a quantitative form was realized. "Strength reserve" according to the diagnostic index value, coincidence of the verified diagnosis with the histologic conclusion, and its invariability for all 12 iterations testified to the reliability of an expert system. Preliminary trials showed the efficiency of an expert system for differentiating the nature of a thyroid follicular tumor to be 97.5%. The developed expert system allows high efficiency in making a differential diagnosis of thyroid follicular cancer and follicular adenoma.

  19. Analysis on Lightning Surge Propagation in Wind Farm (United States)

    Yasuda, Yoh; Hara, Takehisa; Funabashi, Toshihisa

    Wind power generation is expected to become more important in the future distribution system. Although several prospective reports such as IEC 61400-24 and NREL SR-500-31115 indicate on insulation scheme and grounding design for lightning protection, it still seems that there are not many investigations on the problems. This paper therefore discusses lightning surge analysis using wind farm model with 2 or 10 ideal wind turbines. Changing parameters such as grounding resistance and lightning strike points, several cases were studied. As the result of the analysis using digital simulator ARENE, it is clear that the surge tends to propagate toward the end of a distribution line in a wind farm and there is possibility of insulation accidents at the other wind turbines when lightning attacks a wind turbine.

  20. Dynamic stall on a pitching and surging airfoil (United States)

    Dunne, Reeve; McKeon, Beverley J.


    Vertical axis wind turbine blades undergo dynamic stall due to the large angle of attack variation they experience during a turbine rotation. The flow over a single blade was modeled using a sinusoidally pitching and surging airfoil in a non-rotating frame with a constant freestream flow at a mean chord Reynolds number of . Two-dimensional, time-resolved velocity fields were acquired using particle image velocimetry. Vorticity contours were used to visualize shear layer and vortex activity. A low-order model of dynamic stall was developed using dynamic mode decomposition, from which primary and secondary dynamic separation modes were identified. The interaction between these two modes was able to capture the physics of dynamic stall and as such can be extended to other turbine configurations and problems in unsteady aerodynamics. Results from the linear pitch/surge frame are extrapolated to the rotating VAWT frame to investigate the behavior of identified flow structures.

  1. Use of historical information in extreme storm surges frequency analysis (United States)

    Hamdi, Yasser; Duluc, Claire-Marie; Deville, Yves; Bardet, Lise; Rebour, Vincent


    The prevention of storm surge flood risks is critical for protection and design of coastal facilities to very low probabilities of failure. The effective protection requires the use of a statistical analysis approach having a solid theoretical motivation. Relating extreme storm surges to their frequency of occurrence using probability distributions has been a common issue since 1950s. The engineer needs to determine the storm surge of a given return period, i.e., the storm surge quantile or design storm surge. Traditional methods for determining such a quantile have been generally based on data from the systematic record alone. However, the statistical extrapolation, to estimate storm surges corresponding to high return periods, is seriously contaminated by sampling and model uncertainty if data are available for a relatively limited period. This has motivated the development of approaches to enlarge the sample extreme values beyond the systematic period. The nonsystematic data occurred before the systematic period is called historical information. During the last three decades, the value of using historical information as a nonsystematic data in frequency analysis has been recognized by several authors. The basic hypothesis in statistical modeling of historical information is that a perception threshold exists and that during a giving historical period preceding the period of tide gauging, all exceedances of this threshold have been recorded. Historical information prior to the systematic records may arise from high-sea water marks left by extreme surges on the coastal areas. It can also be retrieved from archives, old books, earliest newspapers, damage reports, unpublished written records and interviews with local residents. A plotting position formula, to compute empirical probabilities based on systematic and historical data, is used in this communication paper. The objective of the present work is to examine the potential gain in estimation accuracy with the

  2. Rapid Response Measurements of Hurricane Waves and Storm Surge (United States)

    Gravois, U.


    Andrew (1992), Katrina (2005), and Ike (2008) are recent examples of extensive damage that resulted from direct hurricane landfall. Some of the worst damages from these hurricanes are caused by wind driven waves and storm surge flooding. The potential for more hurricane disasters like these continues to increase as a result of population growth and real estate development in low elevation coastal regions. Observational measurements of hurricane waves and storm surge play an important role in future mitigation efforts, yet permanent wave buoy moorings and tide stations are more sparse than desired. This research has developed a rapid response method using helicopters to install temporary wave and surge gauges ahead of hurricane landfall. These temporary installations, with target depths from 10-15 m and 1-7 km offshore depending on the local shelf slope, increase the density of measurement points where the worst conditions are expected. The method has progressed to an operational state and has successfully responded to storms Ernesto (2006), Noel (2007), Fay (2008), Gustav (2008), Hanna (2008) and Ike (2008). The temporary gauges are pressure data loggers that measure at 1 Hz continuously for 12 days and are post-processed to extract surge and wave information. For the six storms studied, 45 out of 49 sensors were recovered by boat led scuba diver search teams, with 43 providing useful data for an 88 percent success rate. As part of the 20 sensor Hurricane Gustav response, sensors were also deployed in lakes and bays inLouisiana, east of the Mississippi river delta. Gustav was the largest deployment to date. Generally efforts were scaled back for storms that were not anticipated to be highly destructive. For example, the cumulative total of sensors deployed for Ernesto, Noel, Fay and Hanna was only 20. Measurement locations for Gustav spanned over 800 km of exposed coastline from Louisiana to Florida with sensors in close proximity to landfall near Cocodrie

  3. Source of a Prominent Poleward Surge During Solar Cycle 24

    CERN Document Server

    Yeates, A R; van Driel-Gesztelyi, L


    As an observational case study, we consider the origin of a prominent poleward surge of leading polarity, visible in the magnetic butterfly diagram during Solar Cycle 24. A new technique is developed for assimilating individual regions of strong magnetic flux into a surface flux transport model. By isolating the contribution of each of these regions, the model shows the surge to originate primarily in a single high-latitude activity group consisting of a bipolar active region present in Carrington Rotations 2104-05 (November 2010-January 2011) and a multipolar active region in Rotations 2107-08 (February-April 2011). This group had a strong axial dipole moment opposed to Joy's law. On the other hand, the modelling suggests that the transient influence of this group on the butterfly diagram will not be matched by a large long-term contribution to the polar field, because of its location at high latitude. This is in accordance with previous flux transport models.

  4. Effect of exposure to continuous light and melatonin on ovarian follicular kinetics in the skipper frog, Rana cyanophlyctis. (United States)

    Udaykumar, K; Joshi, B N


    Ovarian follicular kinetics and gravimetric changes in the ovary and oviducts were studied in the skipper frog, Rana cyanophlyctis, following exposure to continuous light and melatonin treatment during the breeding season. Daily late-afternoon injections of melatonin (15 micrograms subcutaneous) for 30 days decreased the gonadosomatic index (GSI), whereas continuously available melatonin from subcutaneous implants did not influence the GSI compared to those of controls. Exposure to continuous light for 30 days stimulated the GSI, and melatonin given as daily injections prevented the continuous-light induced increase in GSI. Oviductal weights decreased only in the melatonin-injected groups. Data on follicular kinetics revealed a decrease in first-growth-phase (FGP) oocytes and an increase in medium-sized second-growth-phase (MSGP) and large-sized second-growth-phase (LSGP) oocytes following continuous-light exposure. Melatonin administered to continuous-light-exposed frogs did not change the FGP oocyte number; however, it reduced both the MSGP and LSGP oocytes. Melatonin administration to frogs held in a light and dark cycle increased FGP oocytes and decreased MSGP and LSGP oocytes. Atretic follicles increased in all melatonin-treated groups. The results suggest that continuous light stimulates and melatonin inhibits reproductive function in this species.

  5. Controlling near shore nonlinear surging waves through bottom boundary conditions

    CERN Document Server

    Mukherjee, Abhik; Kundu, Anjan


    Instead of taking the usual passive view for warning of near shore surging waves including extreme waves like tsunamis, we aim to study the possibility of intervening and controlling nonlinear surface waves through the feedback boundary effect at the bottom. It has been shown through analytic result that the controlled leakage at the bottom may regulate the surface solitary wave amplitude opposing the hazardous variable depth effect. The theoretical results are applied to a real coastal bathymetry in India.

  6. Wildlife Poaching: Africa’s Surging Trafficking Threat (United States)


    called keratin, an inert substance that is similar in composition to human fingernails and hair. Some of the consequences of wildlife trafficking are...of the few central figures to have been convicted is a Thai trafficker named Chumlong Lem- tongthai, who worked for businesses in Thailand and Laos...4 1 Wildlife Poaching: Africa’s Surging Trafficking Threat By Bradley anderson and Johan Jooste u Spikes in the prices of ivory and rhino horn have

  7. Enkephalin surges in dorsal neostriatum as a signal to eat


    DiFeliceantonio, Alexandra G.; Mabrouk, Omar S.; Kennedy, Robert T.; C. Berridge, Kent


    Compulsive over-consumption of rewards characterizes disorders ranging from binge eating to drug addiction. Here, we provide evidence that enkephalin surges in an anteromedial quadrant of dorsal neostriatum contribute to generating intense consumption of palatable food. In ventral striatum, mu opioid circuitry contributes an important component of motivation to consume rewards [1–4]. In dorsal neostriatum, mu opioid receptors are concentrated within striosomes that receive inputs from limbic ...

  8. Population vulnerability to storm surge flooding in coastal Virginia, USA. (United States)

    Liu, Hua; Behr, Joshua G; Diaz, Rafael


    This study aims to assess the vulnerability of populations to storm surge flooding in 12 coastal localities of Virginia, USA. Population vulnerability is assessed by way of 3 physical factors (elevation, slope, and storm surge category), 3 built-up components (road availability, access to hospitals, and access to shelters), and 3 household conditions (storm preparedness, financial constraints to recovering from severe weather events, and health fragility). Fuzzy analysis is used to generate maps illustrating variation in several types of population vulnerability across the region. When considering physical factors and household conditions, the most vulnerable neighborhoods to sea level rise and storm surge flooding are largely found in urban areas. However, when considering access to critical infrastructure, we find rural residents to be more vulnerable than nonrural residents. These detailed assessments can inform both local and state governments in catastrophic planning. In addition, the methodology may be generalized to assess vulnerability in other coastal corridors and communities. The originality is highlighted by evaluating socioeconomic conditions at refined scale, incorporating a broader range of human perceptions and predispositions, and employing a geoinformatics approach combining physical, built-up, and socioeconomic conditions for population vulnerability assessment. Integr Environ Assess Manag 2016;12:500-509. © 2015 SETAC. © 2015 SETAC.

  9. Mass balance, runoff and surges of Bering Glacier, Alaska

    Directory of Open Access Journals (Sweden)

    W. Tangborn


    Full Text Available The historical net, ablation and accumulation daily balances, as well as runoff of Bering Glacier, Alaska are determined for the 1951–2011 period with the PTAA (precipitation-temperature-area-altitude model, using daily precipitation and temperature observations collected at the Cordova and Yakutat weather stations, together with the area-altitude distribution of the glacier. The model mean annual balance for this 61 yr period is −0.6 m w.e., the accumulation balance is +1.4 and the ablation balance is −2.0 m w.e. Average annual runoff is 2.5 m w.e. Periodic surges of this glacier transport large volumes of ice to lower elevations where the ablation rate is higher, producing more negative balances and increasing runoff. Runoff from Bering Glacier (derived from simulated ablation and precipitation as rain is highly correlated with four of the glacier surges that have occurred since 1951. Ice volume loss for the 1972–2003 period measured with the PTAA model is 2.7 km3 w.e. a−1 and closely agrees with losses for the same period measured with the geodetic method. It is proposed that the timing and magnitude of daily snow accumulation and runoff, both of which are controlled by the glacier's area-altitude distribution and are calculated with the PTAA model, can be used to determine the probability that a glacier will surge.

  10. New insights in the ongoing surge of the Austfonna icecap (United States)

    Schellenberger, T.; Dunse, T.; Kääb, A.; Hagen, J. O.; Schuler, T.; Reijmer, C.


    Basin-3, a major drainage basin of the Austfonna icecap in NE-Svalbard switched to full surge mode in autumn 2012 after a multiannual, stepwise acceleration of its northern branch. A time series of velocity maps from repeat TerraSAR-X acquisitions revealed a maximum speed at the terminus of >18 m d-1 around the turn of the year 2012. The frontal ablation of Basin-3 was estimated to 4.2±1.6 Gt a-1 between April 2012 and May 2013, tripling the total dynamic mass loss from the largest icecap in the Eurasian arctic. Today, TerraSAR-X, Radarsat-2 and GPS data show that the surge is still ongoing. While the speed at the calving front dropped to 10 m d-1 until July 2014, areas further inland continued to accelerate after the climax, and 10 m d-1 were also measured ~20 km inland in summer 2014. This development will be further investigated by exploiting a time series of velocity maps based on Radarsat-2 Fine Beam data starting from July 2014, which will, other than the TerraSAR-X data, cover almost the entire fast flowing part of the basin. By combining both datasets we will extend the estimation of the frontal ablation and related sea-level rise contribution of the Basin-3 surge.

  11. Hospitals Capability in Response to Disasters Considering Surge Capacity Approach

    Directory of Open Access Journals (Sweden)

    Gholamreza Khademipour


    Full Text Available Background: The man-made and natural disasters have adverse effects with sound, apparent, and unknown consequences. Among various components of disaster management in health sector, the most important role is performed by health-treatment systems, especially hospitals. Therefore, the present study aimed to evaluate the surge capacity of hospitals of Kerman Province in disaster in 2015. Materials and Methods: This is a quantitative study, conducted on private, military, and medical sciences hospitals of Kerman Province. The sampling method was total count and data collection for the research was done by questionnaire. The first section of the questionnaire included demographic information of the studied hospitals and second part examined the hospital capacity in response to disasters in 4 fields of equipment, physical space, human resources, and applied programs. The extracted data were analyzed by descriptive statistics. Results: The mean capability of implementing the surge capacity programs by hospitals of Kerman Province in disasters and in 4 fields of equipment, physical space, human resources, and applied programs was evaluated as 7.33% (weak. The surge capacity capability of state hospitals in disasters was computed as 8% and compared to private hospitals (6.07% had a more suitable condition. Conclusion: Based on the results of study and significance of preparedness of hospitals in response to disasters, it is proposed that managers of studied hospitals take measures to promote the hospital response capacity to disasters based on 4 components of increasing hospital capacity.

  12. Using satellite altimetry and tide gauges for storm surge warning (United States)

    Andersen, O. B.; Cheng, Y.; Deng, X.; Steward, M.; Gharineiat, Z.


    The combination of the coarse temporal sampling by satellite altimeters in the deep ocean with the high temporal sampling at sparsely located tide gauges along the coast has been used to improve the forecast of high water for the North Sea along the Danish Coast and for the northeast coast of Australia. For both locations we have tried to investigate the possibilities and limitations of the use of satellite altimetry to capture high frequency signals (surges) using data from the past 20 years. The two regions are chosen to represent extra-tropical and tropical storm surge conditions. We have selected several representative high water events on the two continents based on tide gauge recordings and investigated the capability of satellite altimetry to capture these events in the sea surface height data. Due to the lack of recent surges in the North Sea we focused on general high water level and found that in the presence of two or more satellites we could capture more than 90% of the high water sea level events. In the Great Barrier Reef section of the northeast Australian coast, we have investigated several large tropical cyclones; one of these being Cyclone Larry, which hit the Queensland coast in March 2006 and caused both loss of lives as well as huge devastation. Here we demonstrate the importance of integrating tide gauges with satellite altimetry for forecasting high water at the city of Townsville in northeast Australia.

  13. Surge dynamics in the Nathorstbreen glacier system, Svalbard

    Directory of Open Access Journals (Sweden)

    M. Sund


    Full Text Available Nathorstbreen glacier system (NGS recently experienced the largest surge in Svalbard since 1936, and is examined using spatial and temporal observations from DEM differencing, time-series of surface velocities from satellite synthetic aperture radar (SAR and other sources. The upper basins with maximum accumulation during quiescence correspond to regions of initial lowering. Initial speed-up exceeds quiescent velocities by a factor of several tens of times. This suggests that polythermal glaciers surges are initiated in the temperate area before mass is displaced downglacier. Subsequent downglacier mass displacement coincides with areas of 100–200 times increased velocities (stage 2. After > 5 yr the joint NGS terminus advanced abruptly into tidewater during winter. The advance was followed by upglacier propagation of crevasses, indicating a re-action following from the already displaced mass and extending flow. NGS advanced ca. 15 km, while another ca. 3 km length was lost due to calving. Surface lowering of ca. 50 m was observed in some upglacier areas and during 5 yr the total area increased by 20%. Maximum measured flow rates were at least 25 m d−1, 2500 times quiescence, while average velocities were about 10 m d−1. The surges of Zawadzkibreen cycle with ca. 70 yr periods.

  14. Mass balance, runoff and surges of the Bering Glacier, Alaska

    Directory of Open Access Journals (Sweden)

    W. Tangborn


    Full Text Available The historical net, ablation and accumulation daily balances and runoff of the Bering Glacier, Alaska are determined for the 1951–2011 period with the PTAA (precipitation-temperature-area-altitude model, using daily precipitation and temperature observations collected at the Cordova and Yakutat weather stations, together with the area-altitude distribution of the glacier. The mean annual balance for this 61-yr period is −0.6 mwe, the accumulation balance is +1.4 and the ablation balance is −2.0 mwe. Periodic surges of this glacier transport large volumes of ice to lower elevations where the ablation rate is higher, producing more negative balances and increasing runoff. During the 1993–1995 surge the average ablation balance is −3.3 mwe, over a meter greater than the 1951–2011 average. Runoff from the Bering Glacier (derived from simulated ablation and precipitation as rain is highly correlated with the four glacier surges that have been observed since 1951. Ice volume loss for the 1972–2003 period measured with the PTAA model is 2.3 km3 we a−1 and closely agrees with losses for the same period measured with the geodetic method.

  15. Spatio-Temporal Gene Expression Profiling during In Vivo Early Ovarian Folliculogenesis: Integrated Transcriptomic Study and Molecular Signature of Early Follicular Growth.

    Directory of Open Access Journals (Sweden)

    Agnes Bonnet

    Full Text Available The successful achievement of early ovarian folliculogenesis is important for fertility and reproductive life span. This complex biological process requires the appropriate expression of numerous genes at each developmental stage, in each follicular compartment. Relatively little is known at present about the molecular mechanisms that drive this process, and most gene expression studies have been performed in rodents and without considering the different follicular compartments.We used RNA-seq technology to explore the sheep transcriptome during early ovarian follicular development in the two main compartments: oocytes and granulosa cells. We documented the differential expression of 3,015 genes during this phase and described the gene expression dynamic specific to these compartments. We showed that important steps occurred during primary/secondary transition in sheep. We also described the in vivo molecular course of a number of pathways. In oocytes, these pathways documented the chronology of the acquisition of meiotic competence, migration and cellular organization, while in granulosa cells they concerned adhesion, the formation of cytoplasmic projections and steroid synthesis. This study proposes the involvement in this process of several members of the integrin and BMP families. The expression of genes such as Kruppel-like factor 9 (KLF9 and BMP binding endothelial regulator (BMPER was highlighted for the first time during early follicular development, and their proteins were also predicted to be involved in gene regulation. Finally, we selected a data set of 24 biomarkers that enabled the discrimination of early follicular stages and thus offer a molecular signature of early follicular growth. This set of biomarkers includes known genes such as SPO11 meiotic protein covalently bound to DSB (SPO11, bone morphogenetic protein 15 (BMP15 and WEE1 homolog 2 (S. pombe(WEE2 which play critical roles in follicular development but other biomarkers

  16. H{α} Surges Aroused by Newly-emerging Satellite Bipolar Magnetic Field (United States)

    Wang, J. F.; Zhou, T. H.; Ji, H. S.


    An Hα surge event occurred at AR NOAA 11259 on 2011 July 22. According to the BBSO (Big Bear Solar Observatory) Hα line-center observations, three surges continuously ejected from the same region to the north of the main-sunspot of AR 11259. All of surges ejected along a straight trajectory, and looked like the reversed Eiffel Tower. The first and second surges had the same process. Two bright points firstly appeared to the north of the main-sunspot. After several minutes, a surge appeared between the two bright points, and then rapidly ejected when the two points got most brightness.When the surge reached the maximum height, it disappeared quickly. However, the third surge appeared without bright points, and its height was only half of the others. Compared with SDO/HMI (Solar Dynamics Observatory/Helioseismic and Magnetic Imager) line-of-sight magnetogram, more than one hour before the first surge appeared, a satellite bipolar magnetic field emerged from the surge-ejection region. The newly-emerging positive magnetic flux showed a distinct decrease several minutes earlier than the ejection of the surges. We assumed that the surges was associated with the reconnection between the newly-emerging bipolar magnetic field and the existing (sunspot) magnetic field.

  17. Field assessment of surge and continuous furrow irrigation methods in relation to tillage systems (United States)

    Mattar, Mohamed A.; El-Saadawy, Mohamed A.; Helmy, Mamdouh A.; Sorour, Hussien M.


    Surge flow irrigation is one of the irrigation techniques for controlling furrow irrigation. The aim of this study was to investigate the effect of surge furrow irrigation on water management compared with continuous irrigation for different tillage systems. An experimental field was treated with various tillage systems (mouldboard plough, chisel plough and rotary plough) and water irrigation application methods (continuous flow, control) in which irrigation water was applied continuously, and surge flow (3-surges, 4-surges and 5-surges) in which irrigation water was applied intermittently until it reached the tail end of the furrow. The results showed that water savings obtained using the surge technique were 18.58, 11.84 and 18.93% lower water use than with continuous flow, for the mouldboard, chisel and rotary ploughs, respectively. The 3-surges treatment with the rotary plough reduced the advance time by 25.36% from that for continuous irrigation. The 4-surges treatment with the mouldboard plough had the highest water application efficiency (88.13%). The 3-surges treatment with the rotary plough had the highest distribution uniformity (85.01%). The rotary plough did not cause as much soil aeration around the root system as the other tillage systems. The field research provided information about surge flow, aimed at reducing advance times and increasing irrigation efficiency.

  18. Can we use crevasse fill ridges for identifying undocumented surge behavior in Svalbard? (United States)

    Farnsworth, W. R.; Ingolfsson, O.; Schomacker, A.; Retelle, M.


    Documenting glaciers that exhibit surge type behavior is crucial, especially as we attempt to use evidence of ice front fluctuations for reconstructing past climate oscillations. Controversy exists regarding the relationship between surge activity and climatic processes such as mass balance. This project identifies undocumented surge type glaciers in Svalbard based on the presence of crevasse fill ridges (CFRs) visible in glacier forelands. Although it is acknowledged that many Svalbard outlet glaciers surge, estimates vary greatly as to the actual number of surge- type glaciers in Svalbard, and their distribution pattern is not well understood. A detailed survey of recent (2008-2011), high resolution imagery from Toposvalbard, provided by the Norwegian Polar Institute, allowed for a rapid analysis of Svalbard outlet glaciers. Using CFRs as indicators of surge behavior has almost doubled the amount of potential surge-type glaciers in central Spitsbergen. This method also highlights numerous other glaciers of potential surge type behavior throughout the archipelago. Limits to the CFR identification method are discussed. Additionally as the forelands of previously reported surge type glaciers were analyzed for CFRs, it was evident that the surge indicators were only present in approximately half of the forelands. Numerous factors control the formation and preservation of CFRs including; glacier size, bedrock lithology, subglacial sediments and clast size as well as glacial fluvial run-off. This poster focuses on the controlling factors for CFR formation and preservation as well as other potential methods for effectively identifying surge behavior.

  19. Performance analysis of surge arrester on high voltage systems using ATP

    Energy Technology Data Exchange (ETDEWEB)

    Nallagownden, P.; Magumane, A.H. [Univ. Teknologi Petronas, Perak (Malaysia); Kanth, K.S.R. [Tenaga National Berhad (Malaysia)


    Lightning strikes are among the major factors that cause failures in electrical power systems. Phase to ground arresters are commonly installed at power transformer terminals to offer some lightning protection. However, it is important to understand the performance of metal oxide arresters under very fast transient overvoltages in order to determine the protection zone of the arrester and to achieve economical benefits. This study investigated lightning overvoltage protection in a complete three-phase scheme of a 500 KV substation. Overvoltages originated from direct lightning stroke on a phase of a real overhead line (OHL) model. The effect of the separation distance of the arrester from the transformer connected at the open end of the substations was investigated as well as the performance of the arrester for different substation configurations. In the first scenario, the connection of the arrester and transformer was done with a direct connection of an overhead line. In the second scenario, the connection of these devices was done through a cable. Both the overhead line and cable lengths were varied and the maximum overvoltages coming to the transformer were recorded. The results showed that there is a direct proportionality between overvoltages and length of the overhead line or cable. As long the length of the line or cable between the arrester and the transformer was increased, the vulnerability of the transformer to receive high overvoltages also increased. Surge overvoltages were found to be very sensitive to impedance of the line or cable. The direct connections of overhead lines between the arrester and transformer make it necessary to add some protective device. It was suggested that surge arresters should be installed every 200 meters along the overhead lines in order to ensure the safety of equipment. 12 refs., 4 tabs., 8 figs.

  20. Improving the luteal phase after ovarian stimulation

    DEFF Research Database (Denmark)

    Andersen, Claus Yding; Vilbour Andersen, K


    The human chorionic gonadotrophin (HCG) trigger used for final follicular maturation in connection with assisted reproduction treatment combines ovulation induction and early luteal-phase stimulation of the corpora lutea. The use of a gonadotrophin-releasing hormone agonist (GnRHa) for final...... follicular maturation has, however, for the first time allowed a separation of the ovulatory signal from the early luteal-phase support. This has generated new information that may improve the currently employed luteal-phase support. Thus, combined results from a number of randomized controlled trials using...

  1. Unique features of storm surges through power transformers 6-35/0 , 4 kV winding connection with the scheme "triangle -star with distributed neutral".

    Directory of Open Access Journals (Sweden)

    Aleksandr Grinev


    Full Text Available This article analyzes the transmission of storm surges in the network 0.38 / 0.22 kV neutral to earth through the power transformers 6-35/0 , 4 kV winding connection with the scheme "triangle -star with distributed neutral ." Proposed equivalent circuit for cases falling storm waves on the three phases simultaneously and fall of waves on one phase. The article can be useful to specialists in the field of electromagnetic compatibility.

  2. Follicular thyroid carcinoma invades venous rather than lymphatic vessels

    Directory of Open Access Journals (Sweden)

    Liu Yulin


    Full Text Available Abstract Follicular thyroid carcinoma (FTC tends to metastasize to remote organs rather than local lymph nodes. Separation of FTC from follicular thyroid adenoma (FTA relies on detection of vascular and/or capsular invasion. We investigated which vascular markers, CD31, CD34 and D2-40 (lymphatic vessel marker, can best evaluate vascular invasion and why FTC tends to metastasize via blood stream to remote organs. Thirty two FTCs and 34 FTAs were retrieved for evaluation. The average age of patients with FTA was 8 years younger than FTC (p = 0.02. The female to male ratio for follicular neoplasm was 25:8. The average size of FTC was larger than FTA (p = 0.003. Fourteen of 32 (44% FTCs showed venous invasion and none showed lymphatic invasion, with positive CD31 and CD34 staining and negative D2-40 staining of the involved vessels. The average number of involved vessels was 0.88 ± 1.29 with a range from 0 to 5, and the average diameter of involved vessels was 0.068 ± 0.027 mm. None of the 34 FTAs showed vascular invasion. CD31 staining demonstrated more specific staining of vascular endothelial cells than CD34, with less background staining. We recommended using CD31 rather than CD34 and/or D2-40 in confirming/excluding vascular invasion in difficult cases. All identified FTCs with vascular invasions showed involvement of venous channels, rather than lymphatic spaces, suggesting that FTCs prefer to metastasize via veins to distant organs, instead of lymphatic vessels to local lymph nodes, which correlates with previous clinical observations.

  3. Do alterations in follicular fluid proteases contribute to human infertility? (United States)

    Cookingham, Lisa Marii; Van Voorhis, Bradley J; Ascoli, Mario


    Cathepsin L and ADAMTS-1 are known to play critical roles in follicular rupture, ovulation, and fertility in mice. Similar studies in humans are limited; however, both are known to increase during the periovulatory period. No studies have examined either protease in the follicular fluid of women with unexplained infertility or infertility related to advanced maternal age (AMA). We sought to determine if alterations in cathepsin L and/or ADAMTS-1 existed in these infertile populations. Patients undergoing in vitro fertilization (IVF) for unexplained infertility or AMA-related infertility were prospectively recruited for the study; patients with tubal or male factor infertility were recruited as controls. Follicular fluid was collected to determine gene expression (via quantitative polymerase chain reaction), enzyme concentrations (via enzyme-linked immunosorbent assays), and enzymatic activities (via fluorogenic enzyme cleavage assay or Western blot analysis) of cathepsin L and ADAMTS-1. The analysis included a total of 42 patients (14 per group). We found no statistically significant difference in gene expression, enzyme concentration, or enzymatic activity of cathepsin L or ADAMTS-1 in unexplained infertility or AMA-related infertility as compared to controls. We also found no statistically significant difference in expression or concentration with advancing age. Cathepsin L and ADAMTS-1 are not altered in women with unexplained infertility or AMA-related infertility undergoing IVF, and they do not decline with advancing age. It is possible that differences exist in natural cycles, contributing to infertility; however, our findings do not support a role for protease alterations as a common cause of infertility.

  4. Effect of stress hormone antagonists on ovarian follicular development in pre-pubertal rat

    Directory of Open Access Journals (Sweden)

    Kalid Hamood Abdullah


    Full Text Available Effect of stress on pre-pubertal ovarian follicular development was studied. Fifteen day old female rats were administered under stress (exposed to maternal separation; 6 hours/day from post-natal day 15 to 21 for 7 days, and appropriate controls were maintained. The time of exposure was randomly changed every day during light phase (7AM to 7 PM of the day to avoid habituation. There was a significant decrease in serum estrogen levels on post-natal day 21 in stress group rats compared to controls indicating stress response in these rats. However, mean number of healthy follicles in all categories of follicles were significantly lower in stressed rats compared to controls. Concomitant with these changes, mean number of atreitic follicles showed an increase over control values in stressed rats. In contrast administration of Naltrexone (5μg NTX/rat/day, Mifepristone (1 μg MP/rat/day, FSH (10 IU FSH/rat/day with stressed the significant increases in the relative weight of ovary, uterus, fallopian tube, body weight and the mean number of healthy follicles in the ovary compared to the controls. In the ovary treatment of stressed did not affect primordial follicles. Primordial follicles were reduced in number significantly in the ovary of controls and treated groups when compared with the initial controls whereas there was no significant variation among the controls and the treated groups. The results indicate that stress dose not interfere with the progress of pre-pubertal follicular development. However, it causes increased loss of follicles by atretia.

  5. Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline. (United States)

    Chi, Woo; Wu, Eleanor; Morgan, Bruce A


    Although the hair shaft is derived from the progeny of keratinocyte stem cells in the follicular epithelium, the growth and differentiation of follicular keratinocytes is guided by a specialized mesenchymal population, the dermal papilla (DP), that is embedded in the hair bulb. Here we show that the number of DP cells in the follicle correlates with the size and shape of the hair produced in the mouse pelage. The same stem cell pool gives rise to hairs of different sizes or types in successive hair cycles, and this shift is accompanied by a corresponding change in DP cell number. Using a mouse model that allows selective ablation of DP cells in vivo, we show that DP cell number dictates the size and shape of the hair. Furthermore, we confirm the hypothesis that the DP plays a crucial role in activating stem cells to initiate the formation of a new hair shaft. When DP cell number falls below a critical threshold, hair follicles with a normal keratinocyte compartment fail to generate new hairs. However, neighbouring follicles with a few more DP cells can re-enter the growth phase, and those that do exploit an intrinsic mechanism to restore both DP cell number and normal hair growth. These results demonstrate that the mesenchymal niche directs stem and progenitor cell behaviour to initiate regeneration and specify hair morphology. Degeneration of the DP population in mice leads to the types of hair thinning and loss observed during human aging, and the results reported here suggest novel approaches to reversing hair loss.

  6. Characterization of ovarian follicular dynamics in dromedary camels (Camelus dromedarius). (United States)

    Manjunatha, B M; Pratap, N; Al-Bulushi, Samir; Hago, B E


    Ovarian follicular dynamics was monitored by transrectal ultrasonography, for a period of 60 to 90 days, and its correlation with plasma estradiol-17β (E2) and progesterone (P4) were studied in seventeen, multiparous, non-lactating, 12 to 20-year-old dromedary camels. The average number of follicles recruited (12.77 ± 0.93) in each wave between animals varied (P dromedary camels and the IWI and follicle numbers recruited per wave are variable between the animals and repeatable within an individual animal.

  7. Congenital systematized basaloid follicular hamartoma with microphthalmia and hemimegalencephaly. (United States)

    Boccaletti, Valeria; Accorsi, Patrizia; Pinelli, Lorenzo; Ungari, Marco; Giordano, Lucio; Neri, Iria; De Panfilis, Giuseppe


    The lines of Blaschko are a cutaneous pattern of mosaicism present in a variety of skin disorders. Developmental abnormalities affecting other tissues derived from the embryonic ectoderm and mesoderm are sometimes associated. Here, we describe a 5-year-old boy with basaloid follicular hamartoma affecting the left side of the body in linear multiple bands, following Blaschko lines. Lesions were predominantly hypopigmented macules and streaks, but among these, we could observe brownish atrophic patches and brown papules. Furthermore, ipsilateral hemimegaloencephaly and microphthalmia were present. These findings suggest a neurocutaneous condition recently described by Happle and Tinschert. Its nosologic classification will be discussed. © 2010 Wiley Periodicals, Inc.

  8. Serum Electrolytes During Different Phases Of Menstrual Cycle

    Directory of Open Access Journals (Sweden)

    Dr. M. A. Lanje,


    Full Text Available Background: Although the coordinated sequence of hormonal changes during the normal menstrual cycle are well characterized, whether similar or parallel changes occur in the distribution of various electrolytes has not been clearly established. Materials and methods: This corollary follow up study on 50 healthy normal menstruating females presents variation in serum calcium, magnesium, sodium and potassium during menstrual, follicular and luteal phases of menstrual cycle. Results: The study demonstrated that serum calcium levels were significantly (p < 0.001 higher in follicular phase than menstrual and luteal phases. Serum magnesium levels were significantly (p < 0.001 lower in follicular phase than menstrual and luteal phases. Serum sodium levels were significantly lower in luteal phase than the menstrual and follicular phases. Serum potassium levels were higher (non-significant in luteal phase than menstrual and follicular phases. Conclusion: The concurrence of these cyclical changes in these electrolytes supports the claim of many women that they suffer changes in fluid and electrolyte balance in the premenstrual days. Moreover, these changes may have significance in terms of the normal reference interval, hence necessitate small but significant lterations to the normal reference interval.

  9. Foliation-Based Parameter Tuning in a Model of the GnRH Pulse and Surge Generator (United States)

    Clement, Frederique; Vidal, Alexandre


    We investigate a model of the GnRH pulse and surge generator, with the definite aim of constraining the model GnRH output with respect to a physiologically relevant list of specifications. The alternating pulse and surge pattern of secretion results from the interaction between a GnRH secreting system and a regulating system exhibiting slow-fast dynamics. The mechanisms underlying the behavior of the model are reviewed from the study of the Boundary-Layer System according to the dissection method principle. Using singular perturbation theory, we describe the sequence of bifurcations undergone by the regulating (FitzHugh-Nagumo) system, encompassing the rarely investigated case of homoclinic connection. Based on pure dynamical considerations, we restrict the space of parameter search for the regulating system and describe a foliation of this restricted space, whose leaves define constant duration ratios between the surge and the pulsatility phase in the whole system. We propose an algorithm to fix the parameter values also to meet the other prescribed ratios dealing with amplitude and frequency features of the secretion signal. We finally apply these results to illustrate the dynamics of GnRH secretion in the ovine species and the rhesus monkey.

  10. The efficacy of controlled internal drug release (CIDR) in synchronizing the follicular wave in dromedary camels (Camelus dromedarius) during the breeding season. (United States)

    Swelum, Ayman Abdel-Aziz; Alowaimer, Abdullah Nasser


    The present study aimed to evaluate the efficacy of controlled internal drug release (CIDR) to synchronize the follicular wave in dromedary camels (Camelus dromedarius) during the breeding season through ovarian monitoring, evaluating sexual receptivity, and measuring progesterone (P4) and estradiol (E2) levels during and after CIDR treatment. Sixteen camels received a new CIDR containing 1.9 g of P4 for 14 days. Ultrasound ovarian monitoring was performed on the day of insertion and every 3 days until the CIDR was withdrawn. Ultrasound examinations were continued day in day out after the CIDR was withdrawn for 10 days. According to the ultrasound examinations, the percentages of camels in the breeding (follicles: 12-18 mm) and nonbreeding phases were calculated. Blood samples were collected day after day during the experimental period (24 days) from the day that the CIDR was inserted. The serum P4 and E2 concentrations were analyzed using ELISA kits. The sexual receptivity of the camels was tested daily during the course of the experiment. The results revealed that 2 and 4 days after the CIDR was withdrawn, the percentage of camels in the breeding phase (68.75% and 75.00%, respectively) was significantly (P dromedary camels. In conclusion, the treatment of dromedary camels with CIDR produced a uniform increase in serum concentrations of P4 that could completely prevent sexual receptivity but could not suppress the follicular wave. After CIDR withdrawal, the P4 levels fell and induced the emergence of a new follicular wave, and most of the camels were in the breeding (ovulatory) phase 2 to 4 days after withdrawal. Therefore, CIDR can be used to synchronize the follicular wave in dromedary camels.

  11. Solar pacing of storm surges, coastal flooding and agricultural losses in the Central Mediterranean. (United States)

    Kaniewski, David; Marriner, Nick; Morhange, Christophe; Faivre, Sanja; Otto, Thierry; Van Campo, Elise


    Storm surges, leading to catastrophic coastal flooding, are amongst the most feared natural hazards due to the high population densities and economic importance of littoral areas. Using the Central Mediterranean Sea as a model system, we provide strong evidence for enhanced periods of storminess leading to coastal flooding during the last 4500 years. We show that long-term correlations can be drawn between storminess and solar activity, acting on cycles of around 2200-yr and 230-yr. We also find that phases of increased storms and coastal flooding have impacted upon mid- to late Holocene agricultural activity on the Adriatic coast. Based on the general trend observed during the second half of the 20(th) century, climate models are predicting a weakening of Mediterranean storminess. By contrast, our new data suggest that a decrease in solar activity will increase and intensify the risk of frequent flooding in coastal areas.

  12. Follicular steroid hormones as markers of oocyte quality and oocyte development potential. (United States)

    Carpintero, Nayara López; Suárez, Onica Armijo; Mangas, Carmen Cuadrado; Varea, Carolina González; Rioja, Rubén Gómez


    Various components of follicular fluid are suggested as biochemical predictors of oocyte quality. Previous studies of follicular steroid hormone levels have shown disparate results when related with fertilization outcomes. The objective of the study was to relate the levels of steroid hormones of each individual follicle with oocyte maturation, fertilization results, embryo quality, and pregnancy rates. Prospective cohort study in a university hospital. In 31 patients, who underwent intracytoplasmic sperm injection, it was performed an ultrasound guided aspiration of follicular fluid of the first two mature follicles from each ovary. Follicular levels of estradiol, progesterone, testosterone, and dehydroepiandrosterone sulfate were measured by chemiluminescent immunoassay. Generalized estimating equation model. In follicular fluids with mature oocyte presence, in normal as well as in failed fertilization, there was a positive correlation between follicular testosterone and progesterone (r = 0.794, P = 0.0001 and r = 0.829, P = 0.0001). Progesterone levels were higher in cases of normal fertilization compared to failed fertilization (P = 0.003). B quality embryos came from oocytes immersed in follicular fluids with higher estradiol values and higher estradiol/progesterone and estradiol/testosterone ratios than those of C quality (P = 0.01; P = 0.0009; P = 0.001). Estradiol levels were higher in patients who achieved pregnancy (P = 0.02). The analysis of follicular hormone composition could be considered as an additional tool in oocyte selection.

  13. Imaging Findings of Follicular Dendritic Cell Sarcoma: Report of Four Cases

    Energy Technology Data Exchange (ETDEWEB)

    Long-Hua, Qiu; Xiao-Yuan, Feng [Affi liated HuaShan Hospital, Fudan University, Shanghai (China); Qin, Xiao; Ya-Jia, Gu; Jian, Wang [Affiliated Cancer Hospital, Fudan University, Shanghai (China)


    Follicular dendritic cell sarcoma is a rare malignant neoplasm and little is known about its radiological features. We present here four cases of follicular dendritic cell sarcomas and we provide the image characteristics of these tumors to help radiologists recognize this entity when making a diagnosis

  14. The effect of follicular wave on fertility characteristics in beef cattle (United States)

    Adequate fertility of beef cattle in the US is a major economic concern. The use of luminogenic substrates to ascertain steroid metabolism in beef females bred to the dominant follicle of the first follicular wave versus the dominant follicle of the second follicular wave in this study further provi...

  15. Early follicular testosterone level predicts preference for masculinity in male faces - but not for women taking hormonal contraception. (United States)

    Bobst, Cora; Sauter, Sabine; Foppa, Andrina; Lobmaier, Janek S


    It has been shown that women's preference for masculinity in male faces changes across the menstrual cycle. Preference for masculinity is stronger when conception probability is high than when it is low. These findings have been linked to cyclic fluctuations of hormone levels. The purpose of the present study is to further investigate the link between gonadal steroids (i.e. testosterone, estradiol, and progesterone) and masculinity preference in women, while holding the cycle phase constant. Sixty-two female participants were tested in their early follicular cycle phase, when conception probability is low. Participants were shown face pairs and where asked to choose the more attractive face. Face pairs consisted of a masculinized and feminized version of the same face. For naturally cycling women we found a positive relationship between saliva testosterone levels and masculinity preference, but there was no link between any hormones and masculinity preference for women taking hormonal contraception. We conclude that in naturally cycling women early follicular testosterone levels are associated with masculinity preference. However, these hormonal links were not found for women with artificially modified hormonal levels, that is, for women taking hormonal contraception. Copyright © 2013 Elsevier Ltd. All rights reserved.


    Institute of Scientific and Technical Information of China (English)

    Zhou Ze-xuan; Tan Soon Keat


    A new kind of governing equations for water hammer based on the elastic column theory was proposed and adopted to analyse water hammer phenomenon in the pipe system with a vertical column surge chamber and water level fluctuation in the surge chamber during pressure transient. The wrongness existing in the classical governing equations for water hammer was analysed. A typical reservoir-valve pipe system was chosen as an example to verify the new governing equations numerically and experimentally. The finite difference method based on the method of characteristics was used to solve numerically the nonlinear characteristic equations. The temporal evolutions of transient volume flux and head and of water level fluctuation for various surge chamber configurations were worked out, assuming that the air in the surge chamber are compressible. The relevant experiment was conducted to verify the new governing equations and numerical method. The numerical and experimental results show that the new governing equations are valid and the conventional assumption that the pressure head at the base of a surge chamber equals that of the static head above it during pressure transient is not always valid. The surge chamber generally reises the period of transient pressure wave in pipe system, reduces the maximum pressure envelope and lifts the minimum envelope substantially. The water level fluctuation in the surge chamber was numerically and experimentally observed. Increasing the size of the surge chamber and/or decreasing the initial air pressure in the surge chamber enhance the effectiveness of the surge chamber in suppressing pressure wave.

  17. Effect of hurricane paths on storm surge response at Tianjin, China (United States)

    Feng, Xingru; Yin, Baoshu; Yang, Dezhou


    A hurricane induced storm surge simulation system was developed for Tianjin coast, which consists of a hurricane model and a storm surge model. The peak storm surge result of the simulation agreed well with that of the observation. Three observed paths (Rita, Mimie and WINNIE) and a hypothetical path (Rita2) were chosen as the selective hurricane paths according to their positions relative to Tianjin. The sensitivity of Tianjin storm surge to the four paths was investigated using the validated storm surge simulation system. Three groups of experiments were done. In group one, the models were forced by the wind field and air pressure; in group two and three the models were forced by the wind only and the air pressure only respectively. In the experiments, the hurricane moved with a fixed speed and an intensity of 50 year return period. The simulation results show that path of the type Rita2 is the easiest to cause storm surge disaster in Tianjin, and the effect of air pressure forcing is most evident for path of the type Rita in Tianjin storm surge process. The above conclusions were analyzed through the evolution of the wind fields and the air pressure distributions. Comparing the experiment results of Group one, two and three, it can be seen that the storm surge is mainly induced by the wind forcing and the nonlinear interaction between the effect of wind forcing and air pressure forcing on the storm surge tends to weaken the storm surge.

  18. Direct Surge Margin Control for Aeroengines Based on Improved SVR Machine and LQR Method

    Directory of Open Access Journals (Sweden)

    Haibo Zhang


    Full Text Available A novel scheme of high stability engine control (HISTEC on the basis of an improved linear quadratic regulator (ILQR, called direct surge margin control, is derived for super-maneuver flights. Direct surge margin control, which is different from conventional control scheme, puts surge margin into the engine closed-loop system and takes surge margin as controlled variable directly. In this way, direct surge margin control can exploit potential performance of engine more effectively with a decrease of engine stability margin which usually happened in super-maneuver flights. For conquering the difficulty that aeroengine surge margin is undetectable, an approach based on improved support vector regression (SVR machine is proposed to construct a surge margin prediction model. The surge margin modeling contains two parts: a baseline model under no inlet distortion states and the calculation for surge margin loss under supermaneuvering flight conditions. The previous one is developed using neural network method, the inputs of which are selected by a weighted feature selection algorithm. Considering the hysteresis between pilot input and angle of attack output, an online scrolling window least square support vector regression (LSSVR method is employed to firstly estimate inlet distortion index and further compute surge margin loss via some empirical look-up tables.

  19. Assessment of Spatial Distribution and Submerged Scope for Storm Surge in the Pearl River Delta Region

    Institute of Scientific and Technical Information of China (English)

    LI Kuo; LI Guo-sheng


    The aim of this study was to explore the spatial distribution and submerged scope for storm surge in the Pearl River Delta (PRD) region.Based on the data of storm surges in the PRD region in the past 30 years, the return periods of 12 tide-gauge stations for storm surges were calculated separately with the methods of Gumbel and Pearson-iii.The data of another six tide-gauge stations in Guangdong Coast was quoted to depict the overall features of storm surges in Guangdong.Using least-square method, the spatial distribution models of storm surges in different retum periods were established to reveal the distribution rule of the set-up values of storm surges.The spatial distribution curves of storm surges in different retum periods in the PRD Region were drawn up based on the models and the terrain of Guangdong Coast.According to the curves, the extreme set-up values of storm surges in 1 000,100, 10 a return periods were determined on each spot of Guangdong Coast.Applying the spatial analysis technology of ArcGIS, with the topography data of the PRD Region, the submerged scopes of flood caused by storm surge in 1 000, 100, 10 a return periods were drawn up.The loss caused by storm surges was estimated.Results showed that the storm surges and the topography of PRD region jointly led to the serious flood in the PRD region.This assessment would be useful for the planning and design department to make decision and provide government scientific basis for storm surge prediction, coastal engineering designing and the prevention of storm surge disaster.

  20. Surges of outlet glaciers from the Drangajökull ice cap, northwest Iceland (United States)

    Brynjólfsson, Skafti; Schomacker, Anders; Korsgaard, Niels J.; Ingólfsson, Ólafur


    Surface elevation and volume changes of the Drangajökull surge-type glaciers, Reykjarfjarðarjökull and Leirufjarðarjökull, were studied by comparing digital elevation models that pre-date and post-date their most recent surges. Annual glacier-frontal measurements were used to estimate average ice velocities during the last surge of the glaciers. The observations show a distinct ice discharge, most of which was from the upper reservoir areas, down to the receiving areas during the surges. The surface draw-down in the reservoir areas was usually 10-30 m during the surges, while the thickening of the receiving areas was significantly more variable, on the order of 10-120 m. Despite a negative geodetic net mass balance derived from the digital elevation models, the reservoir areas have been gaining mass since the surge terminations. This surface thickening along with considerable ablation of the receiving areas will most likely return the glacier surface profiles to the pre-surge stage. Our results indicate that (a) greatest surface thinning in the upper reservoir areas of Drangajökull rather than proximal to the equilibrium line during Vatnajökull surges and (b) development of Drangajökull surges that resembles Svalbard surge-type glaciers rather than Vatnajökull surge-type glaciers. The contrasting surge characteristics could be explained by differences in glacier geometry, topography and substratum of the Drangajökull and Vatnajökull surge-type glaciers.

  1. Acute estrogen surge enhances inflammatory nociception without altering spinal Fos expression. (United States)

    Ralya, Andrew; McCarson, Kenneth E


    Chronic pain is a major neurological disorder that can manifest differently between genders or sexes. The complex actions of sex hormones may underlie these differences; previous studies have suggested that elevated estrogen levels can enhance pain perception. The purpose of this study was to investigate the hypothesis that acute, activational effects of estradiol (E2) increase persistent inflammatory nociception, and anatomically where this modulation occurs. Spinal expression of Fos is widely used as a marker of nociceptive activation. This study used formalin-evoked nociception in ovariectomized (OVX) adult female rats and measured late-phase hindlimb flinching and Fos expression in the spinal cord, and their modification by acute estrogen supplementation similar to a proestrus surge. Six days after ovariectomy, female rats were injected subcutaneously (s.c.) with 10μg/kg E2 or vehicle. Twenty-four hours later, 50μL of 1.25% or 100μL of 5% formalin was injected into the right hindpaw; hindlimb flinches were counted, and spinal cords removed 2h after formalin injection. The numbers of Fos-expressing neurons in sections of the lumbar spinal cord were analyzed using immunohistochemistry. Formalin-induced inflammation produced a dose-dependent increase in late-phase hindlimb flinching, and E2 pretreatment increased flinching following 5%, but not 1.25% formalin injection. Despite the modification of behavior by E2, the number of spinal Fos-positive neurons was not altered by E2 pretreatment. These findings demonstrate that an acute proestrus-like surge in serum estrogen can produce a stimulus-intensity-dependent increase in inflammation-evoked nociceptive behavior. However, the lack of effect on spinal Fos expression suggests that this enhancement of nociceptive signaling by estrogen is independent of changes in peripheral activation of, expression of the immediate early gene Fos by, or signal throughput of spinal nociceptive neurons.

  2. Follicular Proinflammatory Cytokines and Chemokines as Markers of IVF Success

    Directory of Open Access Journals (Sweden)

    Aili Sarapik


    Full Text Available Cytokines are key modulators of the immune system and also contribute to regulation of the ovarian cycle. In this study, Bender MedSystems FlowCytomix technology was used to analyze follicular cytokines (proinflammatory: IL-1β, IL-6, IL-18, IFN-γ, IFN-α, TNF-α, IL-12, and IL-23;, and anti-inflammatory: G-CSF, chemokines (MIP-1α, MIP-1β, MCP-1, RANTES, and IL-8, and other biomarkers (sAPO-1/Fas, CD44(v6 in 153 women undergoing in vitro fertilization (IVF. Cytokine origin was studied by mRNA analysis of granulosa cells. Higher follicular MIP-1α and CD44(v6 were found to correlate with polycystic ovary syndrome, IL-23, INF-γ, and TNF-α with endometriosis, higher CD44(v6 but lower IL-β and INF-α correlated with tubal factor infertility, and lower levels of IL-18 and CD44(v6 characterized unexplained infertility. IL-12 positively correlated with oocyte fertilization and embryo development, while increased IL-18, IL-8, and MIP-1β were associated with successful IVF-induced pregnancy.

  3. Embolization for vertebral metastases of follicular thyroid carcinoma. (United States)

    Smit, J W; Vielvoye, G J; Goslings, B M


    The technique of selective embolization has been applied for years in the treatment of vascular anomalies, severe hemorrhage and benign or malignant tumors, notably vertebral metastases of renal cell carcinoma. Because this technique is relatively easy to perform and offers immediate relief of symptoms, it is an attractive option for patients with vertebral metastases of thyroid carcinoma with signs of spinal cord compression. In these patients, other treatment modalities like radioactive iodine, external irradiation, or surgery are more cumbersome or less effective in the short term. We describe four patients with metastasized follicular thyroid carcinoma, presenting with neurological symptoms due to vertebral metastases. All patients had undergone total thyroidectomy, ranging from 1 month to 4 yr before embolization. Embolization was combined with iodine-131 therapy when appropriate. Selective catheterization of the arteries feeding the metastases was performed, followed by infusion of polyvinyl alcohol particles (Ivalon). The procedure was technically successful in all patients without adverse effects. In the patients described, embolization resulted in rapid resolution of neurological symptoms, sometimes within hours. The therapeutic effect lasted from months to years. We conclude that embolization of vertebral metastases of follicular thyroid carcinoma is an attractive palliative therapeutic option that may offer rapid relief of symptoms.

  4. Surgical Management of Bulky Mediastinal Metastases in Follicular Thyroid Carcinoma

    Directory of Open Access Journals (Sweden)

    Zainal Adwin


    Full Text Available Follicular thyroid adenoma and carcinoma are very common. Benign and malignant lesions are usually indistinguishable from cytology alone and often require confirmatory resection. The spread of follicular carcinoma is usually hematogenous and is treated with surgery and adjuvant radioactive iodine. Very rarely, metastases occur in the mediastinum. Patients usually present with severe compressive symptoms. With proper treatment and follow-up, the prognosis for these type of thyroid malignancies is excellent. In the case presented here, our patient presented to the Universiti Kebangsaan Malaysia Medical Center with a progressively enlarging anterior neck swelling. The swelling had started 10 years before his presentation. We diagnosed him with an advanced thyroid malignancy with bulky mediastinal metastases. After extensive investigations and counseling, we chose to treat the patient with tumor excision and mediastinal metastases resection. Typically, mediastinal resection involves the removal of the sternum and use of an acrylic implant to recreate the sternum. In this case, the sternum and ribs were removed with subsequent myocutaneous flap coverage for the wound defect. Our experience represents an alternative treatment option in cases where implant use is unsuitable.

  5. Sella turcica metastasis from follicular carcinoma of thyroid. (United States)

    Yilmazlar, Selcuk; Kocaeli, Hasan; Cordan, Teoman


    A case of metastasis to the sella turcica from a follicular adenocarcinoma of the thyroid gland is presented. Metastasis to this site is rare and review of the literature reveals only 12 cases of metastatic thyroid carcinoma involving the sella turcica and pituitary gland. The optimal treatment strategy is still to be determined. A 43-year-old woman presented with headache, nausea, visual impairment and galactorrhea. An MRI scan of the cranium revealed an enhancing destructive sellar lesion. The patient underwent transsphenoidal removal of the lesion to alleviate visual loss. The histological features of the sellar tumor were identical to those of a follicular adenocarcinoma partially removed from the thyroid gland 22 months earlier. Total thyroidectomy followed by three courses of iodine-131 ablation enhanced with synthetic thyrotropin and thyroid hormone suppression therapy was instituted. The post-operative course was satisfactory with improved vision and ceased galactorrhea. This case was successfully treated with a combination of surgical removal, iodine-131 ablation and hormone suppression therapy, which resulted in disease control duration of four years. Sella turcica metastases of thyroid carcinoma are exceedingly rare and currently there are no established therapeutic guidelines.

  6. Follicular thyroid carcinoma presenting as bilateral cheek masses. (United States)

    Kim, Dong-Wook; Hah, J Hun; An, Soo-Youn; Chang, Hak; Kim, Kwang Hyun


    Mandibular metastasis of thyroid carcinoma is extremely rare. We present the case of a 46-year-old woman who had bilateral huge cheek masses that had grown rapidly over several years. Intra-oral mucosal tissue biopsy and imaging work-up including computed tomography scan and magnetic resonance imaging were performed and the initial diagnosis was presumed to be central giant cell granuloma. Incidentally detected thyroid lesions were studied with ultra-sonography guided fine needle aspiration and diagnosed as simple benign nodules. Due to continuous oral bleeding and the locally destructive feature of the lesions, we decided to excise the mass surgically. To avoid functional deficit, a stepwise approach was performed: Firstly, the larger left mass was excised and the mandible was reconstructed with a fibular free flap. The final pathologic diagnosis was follicular thyroid cancer. Postoperative I-131 thyroid scan and whole body positron-emissions-tomography were performed. Right side mass was revealed as a thyroid malignancy. Multiple bony metastases were detected. Since further radioactive iodine therapy was required, additional total thyroidectomy and right side mandibulectomy with fibular free flap reconstruction was performed. The patient also underwent high dose radioactive iodine therapy and palliative extra-beam radiotherapy for the metastatic lumbar lesion. Follicular thyroid carcinoma should be considered as a differential diagnosis for mandibular mass lesions.

  7. A patient presenting with spinal cord compression who had two distinct follicular cell type thyroid carcinomas. (United States)

    Koca, E; Sokmensuer, C; Yildiz, B O; Engin, H; Bozkurt, M F; Aras, T; Barista, I; Gurlek, A


    A 61-yr-old woman presented with complaints of weakness and pain in her legs. A magnetic resonance imaging showed a 3 x 5.6 x 7.8 cm mass lesion destructing the T1 and T2 vertebral bodies and compressing the spinal cord. The mass was excised surgically. It was follicular carcinoma metastasis of the cervicodorsal region. Then, she underwent a total thyroidectomy. Pathological examination showed two different types of carcinomas in two different focuses; follicular carcinoma in the left lobe and follicular variant papillary carcinoma in the isthmic lobe. After the operation she was given 100 mCi 131I. This is the first report of a patient who had both metastatic follicular carcinoma and follicular variant papillary carcinoma together.

  8. Trefoil factor 3 (TFF3): a promising indicator for diagnosing thyroid follicular carcinoma. (United States)

    Takano, Toru; Yamada, Hiroya


    Since the introduction of fine needle aspiration biopsy (FNAB) in the 1970's, a preoperative diagnostic technique for thyroid follicular carcinoma has long been awaited. Many markers that distinguish follicular carcinomas from adenomas have been reported; however, most of them have not been confirmed to be beneficial for clinical use. Trefoil factor 3 (TFF3) is a relatively new family of peptides that bears the three-loop trefoil domain. Several groups have reported that the suppression of TFF3 mRNA expression is related to malignant characteristics of thyroid follicular cell-derived tumors and the expression level of TFF3 mRNA is the most promising indicator for diagnosing follicular carcinoma. Development of TFF3-based diagnostic methods is now ongoing and it may not be long before thyroid follicular carcinoma can be diagnosed preoperatively using an aspirated sample from the tumor.

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  19. Vulnerability of Coastal Communities from Storm Surge and Flood Disasters. (United States)

    Bathi, Jejal Reddy; Das, Himangshu S


    Disasters in the form of coastal storms and hurricanes can be very destructive. Preparing for anticipated effects of such disasters can help reduce the public health and economic burden. Identifying vulnerable population groups can help prioritize resources for the most needed communities. This paper presents a quantitative framework for vulnerability measurement that incorporates both socioeconomic and flood inundation vulnerability. The approach is demonstrated for three coastal communities in Mississippi with census tracts being the study unit. The vulnerability results are illustrated as thematic maps for easy usage by planners and emergency responders to assist in prioritizing their actions to vulnerable populations during storm surge and flood disasters.

  20. Two parametric tropical cyclone models for storm surge modeling

    Institute of Scientific and Technical Information of China (English)

    WANG Zhi-li


    In this paper,the two parametric tropical cyclone models for storm surge modeling are further developed.The analytical expressions of tangential and radial velocity distribution are derived from the governing momentum equations,based on the general symmetric pressure distribution proposed by Holland and Fujita.On the basis of the data of several tropical cyclones that occurred in East China Ocean,the shape parameter in pressure model is estimated.Finally,the Fred cyclone(typhoon 199417)is calculated,and comparisons of measured and calculated air pressures and wind speed are presented.

  1. Probabilistic modelling of sea surges in coastal urban areas (United States)

    Georgiadis, Stylianos; Jomo Danielsen Sørup, Hjalte; Arnbjerg-Nielsen, Karsten; Nielsen, Bo Friis


    Urban floods are a major issue for coastal cities with severe impacts on economy, society and environment. A main cause for floods are sea surges stemming from extreme weather conditions. In the context of urban flooding, certain standards have to be met by critical infrastructures in order to protect them from floods. These standards can be so strict that no empirical data is available. For instance, protection plans for sub-surface railways against floods are established with 10,000 years return levels. Furthermore, the long technical lifetime of such infrastructures is a critical issue that should be considered, along with the associated climate change effects in this lifetime. We present a case study of Copenhagen where the metro system is being expanded at present with several stations close to the sea. The current critical sea levels for the metro have never been exceeded and Copenhagen has only been severely flooded from pluvial events in the time where measurements have been conducted. However, due to the very high return period that the metro has to be able to withstand and due to the expectations to sea-level rise due to climate change, reliable estimates of the occurrence rate and magnitude of sea surges have to be established as the current protection is expected to be insufficient at some point within the technical lifetime of the metro. The objective of this study is to probabilistically model sea level in Copenhagen as opposed to extrapolating the extreme statistics as is the practice often used. A better understanding and more realistic description of the phenomena leading to sea surges can then be given. The application of hidden Markov models to high-resolution data of sea level for different meteorological stations in and around Copenhagen is an effective tool to address uncertainty. For sea surge studies, the hidden states of the model may reflect the hydrological processes that contribute to coastal floods. Also, the states of the hidden Markov

  2. High Resolution Hurricane Storm Surge and Inundation Modeling (Invited) (United States)

    Luettich, R.; Westerink, J. J.


    Coastal counties are home to nearly 60% of the U.S. population and industry that accounts for over 16 million jobs and 10% of the U.S. annual gross domestic product. However, these areas are susceptible to some of the most destructive forces in nature, including tsunamis, floods, and severe storm-related hazards. Since 1900, tropical cyclones making landfall on the US Gulf of Mexico Coast have caused more than 9,000 deaths; nearly 2,000 deaths have occurred during the past half century. Tropical cyclone-related adjusted, annualized losses in the US have risen from 1.3 billion from 1949-1989, to 10.1 billion from 1990-1995, and $35.8 billion per year for the period 2001-2005. The risk associated with living and doing business in the coastal areas that are most susceptible to tropical cyclones is exacerbated by rising sea level and changes in the characteristics of severe storms associated with global climate change. In the five years since hurricane Katrina devastated the northern Gulf of Mexico Coast, considerable progress has been made in the development and utilization of high resolution coupled storm surge and wave models. Recent progress will be presented with the ADCIRC + SWAN storm surge and wave models. These tightly coupled models use a common unstructured grid in the horizontal that is capable of covering large areas while also providing high resolution (i.e., base resolution down to 20m plus smaller subgrid scale features such as sea walls and levees) in areas that are subject to surge and inundation. Hydrodynamic friction and overland winds are adjusted to account for local land cover. The models scale extremely well on modern high performance computers allowing rapid turnaround on large numbers of compute cores. The models have been adopted for FEMA National Flood Insurance Program studies, hurricane protection system design and risk analysis, and quasi-operational forecast systems for several regions of the country. They are also being evaluated as

  3. Surge-tectonic evolution of southeastern Asia: a geohydrodynamics approach (United States)

    Meyerhoff, Arthur A.

    The repeated need for ad hoc modifications in plate-tectonic models to explain the evolution of southeastern Asia reveals their inability to fully explain the complex features and dynamics of this region. As one example, the hypothesis does not provide a mechanism to explain the 180° turns and twists along the strike of several foldbelts and island arcs in the region (e.g. Banda arc). Convection-cell configuration renders such 180° contortions and Rayleigh-Bénard-type convection impossible. However, during the last 10 years, new data bearing on the convection-cell problem have become available in the form of seismotomographic images of the earth's interior. These images show that (i) mantle diapirs as proposed by traditional plate-tectonic models do not exist; (ii) there is no discernible pattern of upper or lower mantle convection, and thus no longer an adequate mechanism to move plates; and (iii) the lithosphere above a depth of about 80 km is permeated by an interconnected network of low-velocity channels. Seismic-reflection studies of the low-velocity channels discovered on the seismotomographic images reveal that these channels have walls with a 7.1-7.8 km s -1 P-wave velocity. Commonly, the interiors of the channels are acoustically transparent, with much slower P-wave velocities, in places as low as 5.4 km s -1. The author and co-workers have interpreted the low velocities as evidence for the presence of partial melt in the channels, and they postulated that this melt moves preferentially eastward as a result of the earth's rotation. They named these channels "surge channels" and their new hypothesis for earth dynamics "surge tectonics". Surge channels underlie every type of tectonic belt, which includes mid-ocean ridges, aseismic ridges, continental rifts, strike-slip fracture zones, and foldbelts. In southeastern Asia, surge channels—mainly foldbelts—lie between all platform and cratonic massifs. These massifs, platforms, and tectonics belts

  4. Coastal Flooding Hazards due to storm surges and subsidence

    DEFF Research Database (Denmark)

    Sørensen, Carlo; Knudsen, Per; Andersen, Ole B.

    Flooding hazard and risk mapping are major topics in low-lying coastal areas before even considering the adverse effects of sea level rise (SLR) due to climate change. While permanent inundation may be a prevalent issue, more often floods related to extreme events (storm surges) have the largest...... damage potential.Challenges are amplified in some areas due to subsidence from natural and/or anthropogenic causes. Subsidence of even a few mm/y may over time greatly impair the safety against flooding of coastal communities and must be accounted for in order to accomplish the economically most viable...

  5. Cell-free DNA in human follicular fluid as a biomarker of embryo quality. (United States)

    Scalici, E; Traver, S; Molinari, N; Mullet, T; Monforte, M; Vintejoux, E; Hamamah, S


    Could cell-free DNA (cfDNA) quantification in individual human follicular fluid (FF) samples become a new non-invasive predictive biomarker for in vitro fertilization (IVF) outcomes? CfDNA level in human follicular fluid samples was significantly correlated with embryo quality and could be used as an innovative non-invasive biomarker to improve IVF outcomes. CfDNA fragments, resulting from apoptotic or necrotic events, are present in the bloodstream and their quantification is already used as a biomarker for gynaecological and pregnancy disorders. Follicular fluid is important for oocyte development and contains plasma components and factors secreted by granulosa cells during folliculogenesis. CfDNA presence in follicular fluid and its potential use as an IVF outcome biomarker have never been investigated. One hundred individual follicular fluid samples were collected from 43 female patients undergoing conventional IVF (n = 26) or ICSI (n = 17). CfDNA level was quantified in each individual follicular fluid sample. At oocyte collection day, follicles were aspirated individually. Only blood-free follicular fluid samples were included in the study. Follicle size was calculated based on the follicular fluid volume. Each corresponding cumulus-oocyte complex was isolated for IVF or ICSI procedures. Follicular fluid cfDNA was measured by quantitative PCR with ALU-specific primers. Human follicular fluid samples from individual follicles contain measurable amounts of cfDNA (mean ± SD, 1.62 ± 2.08 ng/µl). CfDNA level was significantly higher in small follicles (8-12 mm in diameter) than in large ones (>18 mm) (mean ± SD, 2.54 ± 0.78 ng/µl versus 0.71 ± 0.44 ng/µl, respectively, P = 0.007). Moreover, cfDNA concentration was significantly and negatively correlated with follicle size (r = -0.34; P = 0.003). A weak significant negative correlation between DNA integrity and 17β-estradiol level in follicular fluid samples at oocyte collection day was observed (r = -0

  6. Simulation of Storm Surge and Wave Due to Typhoon Isewan (5915)

    Institute of Scientific and Technical Information of China (English)

    Jin-Hee YUK; Kyeong Ok KIM; Han Soo LEE; Byung Ho CHOI


    An integrally coupled wave-tide-surge model was developed and then applied to the simulation of the wave-typhoon surge for the typhoon Isewan (typhoon Vera (5915)), which is the strongest typhoon that has struck Japan and caused incalculable damage. An integrally coupled tide-surge-wave model using identical and homogeneous meshes in an unstructured grid system was used to correctly resolve the physics of wave-circulation interaction in both models. All model components were validated independently. The storm surge and wave properties such as the surge height, the significant wave height, wave period and direction were reproduced reasonably under the meteorological forcing, which was reprocessed to be close to the observations. The resulting modeling system can be used extensively for the prediction of the storm surge and waves and the usual barotropic forecast.

  7. Effectiveness of installing two pairs of distribution surge arresters in parallel

    Energy Technology Data Exchange (ETDEWEB)

    Sugimoto, Hitoshi; Asakawa, Akira; Yokoyama, Shigeru [Central Research Institute of Electric Power Industry (Japan); Nakada, Kazuo [Hokurika Electric Power Co. (Japan)


    Lightning strokes with a large amount of energy sometimes occur on the Sea of Japan coast in winter. Winter lightning often damages overhead power distribution lines, in particular, those supplying power to high structures located in mountainous areas. We have investigated that the ratio of surge arrester outages with respect to all damaged installations on such power distribution lines is largest at approximately 50%. We have examined the effectiveness of installing two pairs of surge arresters in parallel on a single pole as a method for preventing distribution surge arrester outages experimentally. We have clarified that to install surge arresters in parallel is effective in reducing the energy absorbed by surge arresters if these surge arresters have almost the same discharge voltage and voltage-current characteristics. (author)

  8. Cardiovascular response to short-term fasting in menstrual phases in young women: an observational study. (United States)

    Ohara, Kumiko; Okita, Yoshimitsu; Kouda, Katsuyasu; Mase, Tomoki; Miyawaki, Chiemi; Nakamura, Harunobu


    Menstrual cycle-related symptoms are an important health issue for many women, and some may affect cardiac autonomic regulation. In the present study, we evaluated the cardiovascular and physiological stress response to 12-h short-term fasting in the menstrual phases of healthy young women. We performed a randomized crossover study. Subjects were seven female university students (age: 22.3 ± 1.0 years). The experiments comprised four sessions: meal intake in the follicular phase, meal intake in the luteal phase, fasting in the follicular phase, and fasting in the luteal phase. All subjects participated in a total of four experimental sessions during two successive phases (follicular and luteal phase in the same menstrual cycle, or luteal phase and follicular phase in the next menstrual cycle) according to a randomized crossover design. R-R intervals were continuously recorded before and after meals, and power spectral analysis of heart rate variability was performed. Other physiological data were obtained before and 20, 40, 60, and 80 min after meal intake or after the corresponding time point of meal intake (fasting in the follicular or luteal phase). Heart rate decreased during fasting in the follicular and luteal phases. High frequency power increased during fasting in the follicular and luteal phases. In addition, salivary cortisol concentrations decreased during fasting in the luteal phase. In the present study, short-term fasting resulted in higher parasympathetic activity and lower cortisol levels in the luteal phase in these young women. These results indicate a possibility to produce an anti-stress effect in the luteal phase, which may reduce menstrual symptoms.

  9. Effect of PSD on Acoustic Cavitation Surge in Inlet Pipe of Turbopump


    吉田, 義樹; 藤原, 徹也; 南里, 秀明; Yoshida, Yoshiki; Fujiwara, Tetsuya; Nanri, Hideaki


    To investigate the effect of PSD on acoustic cavitation surge in turbopump, we conducted analyses with the resistance of PSD as a parameter. Consequently, we found that patterns of the acoustic cavitation surge were classified into three types by the value of the resistance. (1) First (the resistance of the PSD is smaller.), when the frequency of the inertial cavitation surge between the PSD and the turbopump coincides with the acoustic natural frequencies between the tank and the PSD, the ac...

  10. Characteristics and possibilities of software tool for metal-oxide surge arresters selection

    Directory of Open Access Journals (Sweden)

    Đorđević Dragan


    Full Text Available This paper presents a procedure for the selection of metal-oxide surge arresters based on the instructions given in the Siemens and ABB catalogues, respecting their differences and the characteristics and possibilities of the software tool. The software tool was developed during the preparation of a Master's thesis titled, 'Automation of Metal-Oxide Surge Arresters Selection'. An example is presented of the selection of metal-oxide surge arresters using the developed software tool.

  11. Mapping and Visualization of Storm-Surge Dynamics for Hurricane Katrina and Hurricane Rita (United States)

    Gesch, Dean B.


    The damages caused by the storm surges from Hurricane Katrina and Hurricane Rita were significant and occurred over broad areas. Storm-surge maps are among the most useful geospatial datasets for hurricane recovery, impact assessments, and mitigation planning for future storms. Surveyed high-water marks were used to generate a maximum storm-surge surface for Hurricane Katrina extending from eastern Louisiana to Mobile Bay, Alabama. The interpolated surface was intersected with high-resolution lidar elevation data covering the study area to produce a highly detailed digital storm-surge inundation map. The storm-surge dataset and related data are available for display and query in a Web-based viewer application. A unique water-level dataset from a network of portable pressure sensors deployed in the days just prior to Hurricane Rita's landfall captured the hurricane's storm surge. The recorded sensor data provided water-level measurements with a very high temporal resolution at surveyed point locations. The resulting dataset was used to generate a time series of storm-surge surfaces that documents the surge dynamics in a new, spatially explicit way. The temporal information contained in the multiple storm-surge surfaces can be visualized in a number of ways to portray how the surge interacted with and was affected by land surface features. Spatially explicit storm-surge products can be useful for a variety of hurricane impact assessments, especially studies of wetland and land changes where knowledge of the extent and magnitude of storm-surge flooding is critical.

  12. The 1982 eruptions of El Chichon volcano, Mexico (3): Physical properties of pyroclastic surges (United States)

    Sigurdsson, H.; Carey, S. N.; Fisher, R. V.


    Two major pyroclastic surges generated during the 4 April 1982 eruption of El Chichon devastated an area of 153 km2 with a quasi-radial distribution around the volcano. The hot surge clouds carbonized wood throughout their extent and were too hot to allow accretionary lapilli formation by vapor condensation. Field evidence indicates voidage fraction of 0.99 in the surge cloud with extensive entrainment of air. Thermal calculations indicate that heat content of pyroclasts can heat entrained air and maintain high temperatures in the surge cloud. The dominant bed form of the surge deposits are sand waves shaped in dune forms with vertical form index of 10 20, characterized by stoss-side erosion and lee-side deposition of 1 10 cm reversely graded laminae. A systematic decrease in maximum lithic diameter with distance from source is accompanied by decrease in wavelength and amplitude. Modal analysis indicates fractionation of glass and pumice from the surge cloud relative to crystals, resulting in loss of at least 10% 25% of the cloud mass due to winnowing out of fines during surge emplacement. Greatest fractionation from the -1.0 0.0-∅ grain sizes reflects relatively lower pumice particle density in this range and segregation in the formative stages of the surge cloud. Extensive pumice rounding indicates abrasion during bed-load transport. Flow of pyroclastic debris in the turbulent surge cloud was by combination of bed-load and suspended-load transport. The surges are viewed as expanding pyroclastic gravity flows, which entrain and mix with air during transport. The balance between sedimentation at the base of the surge cloud and expansion due to entrainment of air contributed to low cloud density and internal turbulence, which persisted to the distal edge of the surge zone.

  13. Surge currents and voltages at the low voltage power mains during lightning strike to a GSM tower

    Energy Technology Data Exchange (ETDEWEB)

    Markowska, Renata [Bialystok Technical University (Poland)], E-mail:


    The paper presents the results of numerical calculations of lightning surge currents and voltages in the low voltage power mains system connected to a free standing GSM base station. Direct lightning strike to GSM tower was studied. The analysis concerned the current that flows to the transformer station through AC power mains, the potential difference between the grounding systems of the GSM and the transformer stations and the voltage differences between phase and PE conductors of the power mains underground cable at both the GSM and the transformer sides. The calculations were performed using a numerical program based on the electromagnetic field theory and the method of moments. (author)

  14. Projections of extreme storm surge levels along Europe (United States)

    Vousdoukas, Michalis I.; Voukouvalas, Evangelos; Annunziato, Alessandro; Giardino, Alessio; Feyen, Luc


    Storm surges are an important coastal hazard component and it is unknown how they will evolve along Europe's coastline in view of climate change. In the present contribution, the hydrodynamic model Delft3D-Flow was forced by surface wind and atmospheric pressure fields from a 8-member climate model ensemble in order to evaluate dynamics in storm surge levels (SSL) along the European coastline (1) for the baseline period 1970-2000; and (2) during this century under the Representative Concentration Pathways RCP4.5 and RCP8.5. Validation simulations, spanning from 2008 to 2014 and driven by ERA-Interim atmospheric forcing, indicated good predictive skill (0.06 m relative sea level rise (RSLR), can be further enforced by an increase of the extreme SSL, which can exceed 30 % of the RSLR, especially for the high return periods and pathway RCP8.5. This implies that the combined effect could increase even further anticipated impacts of climate change for certain European areas and highlights the necessity for timely coastal adaptation and protection measures. The dataset is publicly available under this link:

  15. A Comparison of Ensemble Kalman Filters for Storm Surge Assimilation

    KAUST Repository

    Altaf, Muhammad


    This study evaluates and compares the performances of several variants of the popular ensembleKalman filter for the assimilation of storm surge data with the advanced circulation (ADCIRC) model. Using meteorological data from Hurricane Ike to force the ADCIRC model on a domain including the Gulf ofMexico coastline, the authors implement and compare the standard stochastic ensembleKalman filter (EnKF) and three deterministic square root EnKFs: the singular evolutive interpolated Kalman (SEIK) filter, the ensemble transform Kalman filter (ETKF), and the ensemble adjustment Kalman filter (EAKF). Covariance inflation and localization are implemented in all of these filters. The results from twin experiments suggest that the square root ensemble filters could lead to very comparable performances with appropriate tuning of inflation and localization, suggesting that practical implementation details are at least as important as the choice of the square root ensemble filter itself. These filters also perform reasonably well with a relatively small ensemble size, whereas the stochastic EnKF requires larger ensemble sizes to provide similar accuracy for forecasts of storm surge.

  16. New technology and tool prepared for communication against storm surges. (United States)

    Letkiewicz, Beata


    The aim of the presentation is description of the new technology and tool prepared for communication, information and issue of warnings against storm surges. The Maritime Branch of the Institute of Meteorology and Water Management is responsible for preparing the forecast as warning, where the end users are Government Officials and Public. The Maritime Branch carry out the project "Strengthening the administrative capacity in order to improve the management of Polish coastal zone environment" (supported by a grant from Norway through the Norwegian Financial Mechanism). The expected final result of the project is web site One of the activities of the project is - set up of information website, giving public access to the complied data. Information on web site: - meta data - marine data (on-line measurement: sea level, water temperature, salinity, oxygen concentration); - data bases of mathematical model outputs - forecast data (sea level, currents); - ice conditions of the Baltic Sea, - instructions, information materials with information of polish coastal zone. The aim of set up of the portal is development of communication between users of the system, exchange of the knowledge of marine environment and natural hazards such as storm surges, improving the ability of the region in the scope of the data management about the sea environment and the coastal zone.

  17. Blunting post-meal glucose surges in people with diabetes

    Institute of Scientific and Technical Information of China (English)

    Elsamma; Chacko


    Worldwide, the morbidity and mortality associated with non-communicable diseases have been climbing steadily- with costs aggressively keeping pace. This letter highlights a decidedly low-cost way to address the challenges posed by diabetes. High levels of postprandial blood glucose are disproportionately linked to much of the microvascular damage which, in the end, leads to macrovascular complications and organ failures. Systematically controlling post-meal glucose surges is a critical element of overall glycemic management indiabetes. Diet, exercise and medications form a triad of variables that individuals engaged in diabetes selfmanagement may manipulate to achieve their targeted glucose levels. As a rule, diabetes patients in developing countries as well as those living in the pockets of poverty in the western world cannot afford special diets, medications, glucometers and supplies, lab tests and office visits. Exercise is the one option that is readily accessible to all. Decades of research in laboratory settings, viewed holistically, have established that light to moderate aerobic exercise for up to 60 min starting 30 min after the first bite into a meal can blunt the ensuing glucose surge effectively. Moderate resistance exercise, moderate endurance exercise or a combination of the two, practiced post-meal has also been found to improve many cardio-metabolic markers: Glucose, high density lipoprotein, triglycerides, and markers of oxidative stress. On the other hand, pre-breakfast exercise and high-intensity exercise in general have been decidedly counterproductive.

  18. Avoiding compressor surge during emergency shutdown hybridturbine systems

    Energy Technology Data Exchange (ETDEWEB)

    Pezzini, Paolo [University of Genova, Italy; Tucker, David [U.S. DOE; Traverso, Alberto [University of Genova, Italy


    A new emergency shutdown procedure for a direct-fired fuel cell turbine hybrid power system was evaluated using a hardware-based simulation of an integrated gasifier/fuel cell/turbine hybrid cycle (IGFC), implemented through the Hybrid Performance (Hyper) project at the National Energy Technology Laboratory, U.S. Department of Energy (NETL). The Hyper facility is designed to explore dynamic operation of hybrid systems and quantitatively characterize such transient behavior. It is possible to model, test, and evaluate the effects of different parameters on the design and operation of a gasifier/fuel cell/gas turbine hybrid system and provide a means of quantifying risk mitigation strategies. An open-loop system analysis regarding the dynamic effect of bleed air, cold air bypass, and load bank is presented in order to evaluate the combination of these three main actuators during emergency shutdown. In the previous Hybrid control system architecture, catastrophic compressor failures were observed when the fuel and load bank were cut off during emergency shutdown strategy. Improvements were achieved using a nonlinear fuel valve ramp down when the load bank was not operating. Experiments in load bank operation show compressor surge and stall after emergency shutdown activation. The difficulties in finding an optimal compressor and cathode mass flow for mitigation of surge and stall using these actuators are illustrated.

  19. Surge protective device response to steep front transient in low voltage circuit

    Energy Technology Data Exchange (ETDEWEB)

    Marcuz, J.; Binczak, S.; Bilbault, J.M. [Universite de Bourgogne, Dijon (France)], Emails: jerome.marcuz@,,; Girard, F. [ADEE Electronic, Pont de Pany (France)


    Surge propagation on cables of electrical or data lines leads to a major protection problem as the number of equipment based on solid-state circuits or microprocessors increases. Sub-microsecond components of real surge waveform has to be taken into account for a proper protection even in the case of surges caused by indirect lightning effects. The response of a model of transient voltage suppressor diode based surge protection device (SPD) to fast front transient is analytically studied, then compared to simulations, including the lines connected to the SPD and to the protected equipment. (author)

  20. Vulnerability assessment of storm surges in the coastal area of Guangdong Province

    Directory of Open Access Journals (Sweden)

    K. Li


    Full Text Available Being bordered by the South China Sea and with long coastline, the coastal zone of Guangdong Province is often under severe risk of storm surges, as one of a few regions in China which is seriously threatened by storm surges. This article systematically analyzes the vulnerability factors of storm surges in the coastal area of Guangdong (from Yangjing to Shanwei. Five vulnerability assessment indicators of hazard-bearing bodies are proposed, which are social economic index, land use index, eco-environmental index, coastal construction index, and disaster-bearing capability index. Then storm surge vulnerability assessment index system in the coastal area of Guangdong is established. Additionally, the international general mode about coastal vulnerability assessment is improved, and the vulnerability evolution model of storm surges in the coastal area of Guangdong is constructed. Using ArcGIS, the vulnerability zoning map of storm surges in the study region is drawn. Results show that there is the highest degree of storm surge vulnerability in Zhuhai, Panyu, and Taishan; second in Zhongshan, Dongguan, Huiyang, and Haifeng; third in Jiangmen, Shanwei, Yangjiang, and Yangdong; fourth in Baoan, Kaiping, and Enping; and lowest in Guangzhou, Shunde, Shenzhen, and Longgang. This study on the risk of storm surges in these coastal cities can guide the land use of coastal cities in the future, and provide scientific advice for the government to prevent and mitigate the storm surge disasters. It has important theoretical and practical significance.

  1. Regional frequency analysis of extreme storm surges along the French coast

    Directory of Open Access Journals (Sweden)

    L. Bardet


    Full Text Available A good knowledge of extreme storm surges is necessary to ensure protection against flood. In this paper we introduce a methodology to determine time series of skew surges in France as well as a statistical approach for estimating extreme storm surges. With the aim to cope with the outlier issue in surge series, a regional frequency analysis has been carried out for the surges along the Atlantic coast and the Channel coast. This methodology is not the current approach used to estimate extreme surges in France. First results showed that the extreme events identified as outliers in at-site analyses do not appear to be outliers any more in the regional empirical distribution. Indeed the regional distribution presents a curve to the top with these extreme events that a mixed exponential distribution seems to recreate. Thus, the regional approach appears to be more reliable for some sites than at-site analyses. A fast comparison at a given site showed surge estimates with the regional approach and a mixed exponential distribution are higher than surge estimates with an at-site fitting. In the case of Brest, the 1000-yr return surge is 167 cm in height with the regional approach instead of 126 cm with an at-site analysis.

  2. The Anti-surge Capacity of the Surge Arresters for Information System%信息系统避雷器的抗浪涌能力

    Institute of Scientific and Technical Information of China (English)



    The paper describes the basic characteristics about lightning over-voltage, the technology measures of anti-lightning, and the usage and classification of surge arresters. The paper forcus on the Anti-surge capacity of the various surge arresters.%阐述了雷电过电压的基本特性及防雷技术措施,避雷器的用途和分类,重点论述了各种信息系统避雷器的抗浪涌能力。

  3. Extending the Impact of RAC1b Overexpression to Follicular Thyroid Carcinomas (United States)

    Faria, Márcia; Capinha, Liliana; Simões-Pereira, Joana; Bugalho, Maria João; Silva, Ana Luísa


    RAC1b is a hyperactive variant of the small GTPase RAC1 known to be a relevant molecular player in different cancers. Previous studies from our group lead to the evidence that its overexpression in papillary thyroid carcinoma (PTC) is associated with an unfavorable prognosis. In the present study, we intended to extend the analysis of RAC1b expression to thyroid follicular neoplasms and to seek for clinical correlations. RAC1b expression levels were determined by RT-qPCR in thyroid follicular tumor samples comprising 23 follicular thyroid carcinomas (FTCs) and 33 follicular thyroid adenomas (FTAs). RAC1b was found to be overexpressed in 33% of carcinomas while no RAC1b overexpression was documented among follicular adenomas. Patients with a diagnosis of FTC were divided into two groups based on longitudinal evolution and final outcome. RAC1b overexpression was significantly associated with both the presence of distant metastases (P = 0.01) and poorer clinical outcome (P = 0.01) suggesting that, similarly to that previously found in PTCs, RAC1b overexpression in FTCs is also associated with worse outcomes. Furthermore, the absence of RAC1b overexpression in follicular adenomas hints its potential as a molecular marker likely to contribute, in conjunction with other putative markers, to the preoperative differential diagnosis of thyroid follicular lesions. PMID:27127508

  4. Extending the Impact of RAC1b Overexpression to Follicular Thyroid Carcinomas

    Directory of Open Access Journals (Sweden)

    Márcia Faria


    Full Text Available RAC1b is a hyperactive variant of the small GTPase RAC1 known to be a relevant molecular player in different cancers. Previous studies from our group lead to the evidence that its overexpression in papillary thyroid carcinoma (PTC is associated with an unfavorable prognosis. In the present study, we intended to extend the analysis of RAC1b expression to thyroid follicular neoplasms and to seek for clinical correlations. RAC1b expression levels were determined by RT-qPCR in thyroid follicular tumor samples comprising 23 follicular thyroid carcinomas (FTCs and 33 follicular thyroid adenomas (FTAs. RAC1b was found to be overexpressed in 33% of carcinomas while no RAC1b overexpression was documented among follicular adenomas. Patients with a diagnosis of FTC were divided into two groups based on longitudinal evolution and final outcome. RAC1b overexpression was significantly associated with both the presence of distant metastases (P = 0.01 and poorer clinical outcome (P = 0.01 suggesting that, similarly to that previously found in PTCs, RAC1b overexpression in FTCs is also associated with worse outcomes. Furthermore, the absence of RAC1b overexpression in follicular adenomas hints its potential as a molecular marker likely to contribute, in conjunction with other putative markers, to the preoperative differential diagnosis of thyroid follicular lesions.

  5. Proteomic Analysis of the Follicular Fluid of Tianzhu White Yak during Diestrus

    Directory of Open Access Journals (Sweden)

    Jinzhong Tao


    Full Text Available The aim of this study was to identify differentially expressed proteins in the follicular fluid of Tianzhu white yak during diestrus. Follicles obtained from female yak were divided into four groups according to their diameter: 0–2, 2–4, 4–6 mm, and greater than 6 mm. The follicular fluid was directly aspirated from the follicles and mixed according to follicular size, and two-dimensional gel electrophoresis was carried out on the crude follicular fluid samples. Thirty-four differentially expressed spots were generated from these four sizes of follicles. Fourteen of these spots were analyzed by MALDI-TOF/TOF-MS and identified as: AS3MT, VDP, ANKRD6, C10orf107 protein, MRP4, MAPKAP1, AGO3, profilin-β-actin, SPT2 homolog, AGP, AR, RNF20, obscurin-like-1, and one unnamed protein. These proteins were first reported in follicular fluid, in addition to VDP and AGP. Based on existing knowledge of their function and patterns of expression, we hypothesize that most of these differentially expressed proteins play a role in ovarian follicular growth and development, dominant follicle selection, or follicular atresia and development of oocytes; however, the function of the other differentially expressed proteins in reproduction remains ambiguous.

  6. Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes.

    Directory of Open Access Journals (Sweden)

    Balthasar A Heesters


    Full Text Available Despite the success of antiretroviral therapy (ART, it does not cure Human Immunodeficiency Virus (HIV and discontinuation results in viral rebound. Follicular dendritic cells (FDC are in direct contact with CD4+ T cells and they retain intact antigen for prolonged periods. We found that human FDC isolated from patients on ART retain infectious HIV within a non-degradative cycling compartment and transmit infectious virus to uninfected CD4 T cells in vitro. Importantly, treatment of the HIV+ FDC with a soluble complement receptor 2 purges the FDC of HIV virions and prevents viral transmission in vitro. Our results provide an explanation for how FDC can retain infectious HIV for extended periods and suggest a therapeutic strategy to achieve cure in HIV-infected humans.

  7. Selective follicular targeting by modification of the particle sizes. (United States)

    Patzelt, Alexa; Richter, Heike; Knorr, Fanny; Schäfer, Ulrich; Lehr, Claus-Michael; Dähne, Lars; Sterry, Wolfram; Lademann, Juergen


    Hair follicles represent interesting target sites for topically applied substances such as topical vaccinations or agents used in the field of regenerative medicine. In recent years, it could be shown that particles penetrate very effectively into the hair follicles. In the present study, the influence of particle size on the follicular penetration depths was examined. The penetration depths of two different types of particles sized 122 to 1000 nm were determined in vitro on porcine skin. The results revealed that the particles of medium size (643 and 646 nm, respectively) penetrated deeper into the porcine hair follicles than smaller or larger particles. It was concluded that by varying the particle size, different sites within the porcine hair follicle can be targeted selectively. For the human terminal hair follicle, the situation can be expected to be similar due to a similar size ratio of the hair follicles.

  8. A case of follicular lymphoma complicated with mesenteric panniculitis

    Directory of Open Access Journals (Sweden)

    Yotaro Tamai


    Full Text Available Mesenteric panniculitis (MP is a rare disease occasionally complicated with lymphoma. A 55-year old female presented with MP accompanied by malignant lymphoma. This patient was first treated for follicular lymphoma and subsequently for panniculitis. After 6 courses of R-CHOP chemotherapy, the treatment response was partial. An additional course of salvage chemotherapy led to a complete response. Since the mesenteric mass progressed simultaneously with the regression of other lymphoma lesions, we performed a biopsy of the mesenteric mass and pathologically confirmed an MP lesion without lymphoma. Subsequent high-dose chemotherapy led to CR and the MP lesion remained stable. In the present case, MP progressed with chemotherapy. We concluded that mesenteric lesions suspected of progressing or recurring should be diagnosed pathologically even if asymptomatic.

  9. New targets for the treatment of follicular lymphoma

    Directory of Open Access Journals (Sweden)

    Al-Katib Ayad


    Full Text Available Abstract The last two decades have witnessed striking advances in our understanding of the biological factors underlying the development of Follicular lymphoma (FL. Development of newer treatment approaches have improved the outlook for many individuals with these disorders; however, with these advances come new questions. Given the long-term survival of patients with FL, drugs with favourable side-effect profile and minimal long-term risks are desired. FL is incurable with current treatment modalities. It often runs an indolent course with multiple relapses and progressively shorter intervals of remission. The identification of new targets and development of novel targeted therapies is imperative to exploit the biology of FL while inherently preventing relapse and prolonging survival. This review summarizes the growing body of knowledge regarding novel therapeutic targets, enabling the concept of individualized targeted therapy for the treatment of FL.

  10. Eyelash Transplantation Using Leg Hair by Follicular Unit Extraction

    Directory of Open Access Journals (Sweden)

    Sanusi Umar, MD


    Full Text Available Summary: Fine hairs of the head and nape areas have been used as donor sources in eyelash transplantation but are straight, coarse, and grow rapidly, requiring frequent eyelash maintenance. This is the first reported case of eyelash transplantation by follicular unit extraction using leg hair as a donor source; findings were compared with that of another patient who underwent a similar procedure with donor hairs from the nape area. Although both patients reported marked improvement in fullness of eyelashes within 3 months postsurgery, the transplanted leg hair eyelashes required less frequent trimming (every 5–6 weeks compared with nape hair eyelashes (every 2–3 weeks. Additionally, in leg hair eyelashes, the need for perming to sustain a natural looking eyelash curl was eliminated. Eyelash transplantation using leg donor hair in hirsute women may result in good cosmetic outcomes and require less maintenance compared with nape donor hair.

  11. Granulosa cell proliferation differentiation and its role in follicular development

    Institute of Scientific and Technical Information of China (English)

    LU Cuiling; YANG Wei; HU Zhaoyuan; LIU Yixun


    Granuiosa cells (GCs) are the most important cells in the ovary that undergo serious changes morphologically and physiologically during the processes of follicular proliferation, differentiation, ovulation, lutenization and atresia. Oocyte (OC) directs GC proliferation and differentiation, while GCs influence OC maturation. Many ovarian factors are involved in the regulation of these processes via different molecular mechanisms and signal pathways. P38MAPK can selectively regulate steroidogenesis in GCs controlled by FSH; Transcript factors LRH-1 and DAX-1 play an important role in this process; FSH induces GC prolfferation and differentiation by stimulating PCNA and StAR expression and steroidogenesis. Activated ERK1/2 signal pathway may be involved in the FSH-regulated GC proliferation and differentiation. Therefore, GC is an ideal model for studying cell proliferation, differentiation and interaction,as well as signal transduction. This review briefly summarizes the latest data in the literature, including the results achieved in our laboratory.

  12. 3-D simulation of transient flow patterns in a corridor-shaped air-cushion surge chamber based on computational fluid dynamics

    Institute of Scientific and Technical Information of China (English)

    XIA Lin-sheng; CHENG Yong-guang; ZHOU Da-qing


    The 3-D characteristics of the water-air flow patterns in a corridor-shaped air-cushion surge chamber during hydraulic transients need to be considered in the shape optimization.To verify the reliability of the water-air two-phase model,namely,the volume of fluid model,the process of charging water into a closed air chamber is successfully simulated.Using the model,the 3-D flow characteristics under the load rejection and acceptance conditions within the air-cushion surge chamber of a specific hydropower station are studied.The flee surface waves,the flow patterns,and the pressure changes during the surge wave process are analyzed in detail.The longitudinal flow of water in the long corridor-shaped surge chamber is similar to the open channel flow with respect to the wave propagation,reflection and superposition characteristics.The lumped parameters of the 3-D numerical simulation agree with the results of a 1-D calculation of hydraulic transients in the whole water conveying system,which validates the 3-D method.The 3-D flow structures obtained can be applied to the shape optimization of the chamber.

  13. Numerical model for surge and swab pressures on wells with cross-section variation

    Energy Technology Data Exchange (ETDEWEB)

    Fedevjcyk, Joao Victor; Junqueira, Silvio Luiz de Mello; Negrao, Cezar Otaviano Ribeiro [UTFPR - Federal University of Technology - Parana - Curitiba, PR (Brazil)], e-mails:,


    Drilling is one of the most complex steps in petroleum exploration. The process is accomplished by rotating a drill bit to compress the rock formation. During drilling, a fluid is pumped into the well to lubricate and cool down the drill bit, to clean up the well, to avoid the formation fluid influx to the well and also to stabilize the borehole walls. Fluid circulation, however, can be interrupted for maintenance reasons and the drill pipe can be moved to remove the drill bit. The downward or upward movement of the drill pipe displaces the fluid within the well causing either under pressure (swab) or over pressure (surge), respectively. If the pressure at the well bore overcomes the formation fracture pressure, a loss of circulation can take place. On the other way round, the upward movement may reduce the pressure below the pore pressure and an inflow of fluid to the well (kick) can occur. An uncontrolled kick may cause a blowout with serious damages. The transient flow induced by the axial movement of the drill pipe is responsible for the pressure changes at the well bore. Nevertheless, the well bore cross section variation may modify the pressure change within the pipe. In this paper, the effects of diameter variation of the drilling well on the surge and swab pressures are investigated. The equations that represent the phenomenon (mass and momentum conservation) are discretized by the finite volume method. Despite its non-Newtonian properties, the fluid is considered Newtonian in this first work. The drill pipe is considered closed and the flow is assumed as single-phased, one-dimensional, isothermal, laminar, compressible and transient. A sensitivity analysis of the flow parameters is carried out. The cross-section changes cause the reflection of the pressure wave, and consequently pressure oscillations. (author)

  14. Proliferation of granulosa and thecal cells in germinal disc and non-disc regions during follicular growth in Japanese quail (Coturnix coturnix japonica): bromodeoxyuridine incorporation in situ. (United States)

    Yoshimura, Y; Okamoto, T; Tamura, T


    Proliferation of granulosa and thecal cells was analysed during ovarian follicular growth in laying Japanese quail. The birds were injected intraperitoneally with bromodeoxyuridine (BrdU) 10 or 4 h before ovulation, that is, before or after a preovulatory LH surge, respectively, and incorporation of BrdU by follicular tissues was detected immunocytochemically. Cells labelled with BrdU were seldom seen in the most immature follicles in the ovarian cortex, whereas many granulosa and thecal cells were labelled with BrdU in medium-sized white yolky follicles (approximately 13.3% and 14.4% in granulosa and theca layers, respectively). Ten and four hours before ovulation, the granulosa cells in the germinal disc and non-disc regions of the third largest yellow yolky follicle (F3) were labelled with BrdU (approximately 8.4% and 9.4% in germinal disc; 6.1% and 9.0% in the non-disc region), but only those in the germinal disc region were labelled (approximately 5.4% and 4.0%) in the largest yellow yolky follicle (F1). The percentage of thecal cells labelled with BrdU 4 h before ovulation was significantly higher than the percentage labelled 10 h before ovulation, and was higher in F3 (approximately 11.7%) than in F1 follicles (approximately 5.4%) 4 h before ovulation. These results show that proliferation of granulosa and thecal cells occurs in both germinal disc and non-disc regions in growing follicles, but when a follicle matures proliferation is reduced and in the case of granulosa cells it is restricted to the germinal disc region.

  15. Differential Diagnosis of a Follicular Carcinoma and Papillary Carcinoma of the Thyroid Gland Based on Sonographic Findings

    Energy Technology Data Exchange (ETDEWEB)

    Yi, Kyung Sik; Bae, Il Hun; Lee, Seung Young; Jeon, Min Hee [Chungbuk National University College of Medicine, Cheongju (Korea, Republic of)


    The purpose of this study was to evaluate and compare the sonographic findings of a conventional papillary carcinoma, follicular carcinoma and a follicular variant of a papillary carcinoma. A total of 308 nodules from 231 patients that were diagnosed with a papillary carcinoma and a follicular carcinoma by surgery after sonography were analyzed. The nodules consisted of a conventional papillary carcinoma (255, 83%), a follicular variant of a papillary carcinoma (25, 8%), and a follicualar carcinoma (28, 9%). We compared and analyzed the sonographic findings of each nodule for content, margin, echotexture, shape, calcification and halo sign. A conventional papillary carcinoma showed significant different sonographic findings than a follicular carcinoma and a follicular variant of a papillary carcinoma for an ill-defined or well-defined spiculated margin (63.1%), marked hypoechogenicity (85.9%) and microcalcification (49%). A follicular carcinoma showed a significant difference than a conventional papillary carcinoma for a well-defined smooth margin (92.9%), iso, hypo- or hyperechogenicity (89.3%), wider than tall shape (100%) and halo sign (82.1%). The follicular variant of a papillary carcinoma showed similar findings to a follicular carcinoma except for marked hypoechogenicity (44%, p = 0.006) and taller than wide shape (16%, p = 0.027). The follicular carcinoma and follicular variant of a papillary carcinoma showed similar sonographic findings, but findings of a conventional papillary carcinoma were different

  16. Perfluoroalkyl acid contamination of follicular fluid and its consequence for in vitro oocyte developmental competence. (United States)

    Petro, Evi M L; D'Hollander, Wendy; Covaci, Adrian; Bervoets, Lieven; Fransen, Erik; De Neubourg, Diane; De Pauw, Ingrid; Leroy, Jo L M R; Jorssen, Ellen P A; Bols, Peter E J


    Perfluoroalkyl acids (PFAAs) have been shown to induce negative effects in laboratory animals and in vitro experiments. Also, PFAAs have been detected in human tissues and body fluids. The ovarian follicle constitutes a fragile micro-environment where interactions between hormones, growth factors, the oocyte and surrounding somatic cells are essential to generate a fully competent oocyte. In vitro experiments suggest that PFAAs can influence this balance, but very scarce in vivo data are available to confirm this assumption. In fact, the potential PFAA-presence in the follicular micro-environment is currently unknown. Therefore, we investigated if PFAAs are present in human follicular fluid and if their presence could be a risk factor for in vivo exposed developing oocytes. Furthermore, we compared the PFAA-distribution within serum and follicular fluid. PFAAs were analyzed by LC/MS in follicular fluid (n=38) and serum (n=20) samples from women undergoing assisted reproductive technologies (ARTs). Statistical models were used to investigate PFAA-distribution in both body fluids, to compare this behavior with the distribution of lipophilic organic pollutants and to explore the relationship between patient characteristics, ART-results and follicular fluid contamination. Perfluorooctane sulfonate (PFOS) was the PFAA found in the highest concentration in follicular fluid [7.5 (0.1-30.4) ng/mL] and serum [7.6 (2.8-12.5) ng/mL]. A new variable, Principal Component 1, representing the overall PFAA-contamination of the follicular fluid samples, was associated with a higher fertilization rate (porganic pollutants as explanatory variables. To conclude, overall higher PFAA-contamination in the follicular micro-environment was associated with a higher chance of an oocyte to develop into a high quality embryo. Also, PFAAs have different distribution patterns between serum and follicular fluid compared to the lipophilic organic pollutants. Further research is of course crucial

  17. Cortisol concentrations in follicular fluid of 'low responder' patients. (United States)

    Bider, D; Shine, S; Tur-Kaspa, I; Levron, J; Dor, J


    The study was undertaken to examine any differences existing in total cortisol concentrations in the follicular fluid (FF) of pre-ruptured follicles between 'low responder' patients (group 1, n = 20) and 'good responder' patients (group 2, n = 15). The groups were defined according to how many oocytes had been retrieved during the previous in-vitro fertilization procedure (group 1: three or fewer; group 2: more than three) and total oestradiol concentration at previous in-vitro fertilization (IVF) (group 1: 500 pg/ml). All patients were aged 36-43 years (group 1 mean +/- SD: 38.2 +/- 4.7; group 2: 32.1 +/- 3.8 years) and were diagnosed with tubal or unexplained infertility. The total FF cortisol concentrations obtained in conjunction with an IVF procedure were assayed and related to oocyte fertilization. Follicular fluid was analysed for total cortisol content. Only follicles between 19 and 20 mm diameter were analysed in both groups. After aspiration of blood-free FF, total cortisol concentrations were measured by radioimmunoassay, designed for the quantitative measurement of cortisol, and related to oocyte fertilization. Total cortisol concentration in FF from fertilized oocytes was 9.7 +/- 0.6 microg/ml (mean +/- SD) in group 1 compared to 9.2 +/- 4.4 microg/ml in group 2 (not statistically significant). Total cortisol concentrations were not associated with oocyte fertilization and no difference between the groups was found in total cortisol concentrations in the FF of unfertilized oocytes or empty follicles.

  18. Effects of propylene glycol drenching before and after luteolysis on blood glucose, ovarian steroids and follicular dynamics in heifers. (United States)

    Umeki, A; Tanaka, T; Kamomae, H


    The effect of propylene glycol drenching on ovarian and hormonal dynamics was studied in heifers. Five cycling heifers were used twice (as control and treatment) with crossover design. After the confirmation of ovulation (day 0), the heifers in the treatment group received propylene glycol on days 6, 7 and 8 as an oral drench (250 ml of 90% propylene glycol). On day 10, prostaglandin F2α (PGF2α), 15 mg per head of dinoprost, was administered intramuscularly to induce luteal regression followed by the follicular phase and then propylene glycol was again administered twice daily (500 ml/day) on days 10, 11 and 12. Palpation per rectum and ovarian ultrasonography were performed every other day from days 0 to 10, and daily after PGF2α administration until the subsequent ovulation (second ovulation) for analysis of follicular and luteal dynamics. Blood samples were also collected every other day from days 0 to 10, and then at 6 h intervals after PGF2α administration until the second ovulation. For the samples taken at 6-h intervals after PGF2α administration, the concentrations of glucose showed clear daily fluctuations in both groups. Changes in the plasma concentration of glucose in the treatment group were significantly (P propylene glycol drenching in heifers. However, no significant changes in ovarian and hormonal dynamics were found under such metabolic conditions.

  19. Changes in large-scale chromatin structure and function during oogenesis: a journey in company with follicular cells. (United States)

    Luciano, Alberto M; Franciosi, Federica; Dieci, Cecilia; Lodde, Valentina


    The mammalian oocyte nucleus or germinal vesicle (GV) exhibits characteristic chromatin configurations, which are subject to dynamic modifications through oogenesis. Aim of this review is to highlight how changes in chromatin configurations are related to both functional and structural modifications occurring in the oocyte nuclear and cytoplasmic compartments. During the long phase of meiotic arrest at the diplotene stage, the chromatin enclosed within the GV is subjected to several levels of regulation. Morphologically, the chromosomes lose their individuality and form a loose chromatin mass. The decondensed configuration of chromatin then undergoes profound rearrangements during the final stages of oocyte growth that are tightly associated with the acquisition of meiotic and developmental competence. Functionally, the discrete stages of chromatin condensation are characterized by different level of transcriptional activity, DNA methylation and covalent histone modifications. Interestingly, the program of chromatin rearrangement is not completely intrinsic to the oocyte, but follicular cells exert their regulatory actions through gap junction mediated communications and intracellular messenger dependent mechanism(s). With this in mind and since oocyte growth mostly relies on the bidirectional interaction with the follicular cells, a connection between cumulus cells gene expression profile and oocyte developmental competence, according to chromatin configuration is proposed. This analysis can help in identifying candidate genes involved in the process of oocyte developmental competence acquisition and in providing non-invasive biomarkers of oocyte health status that can have important implications in treating human infertility as well as managing breeding schemes in domestic mammals.

  20. Hormonal, follicular and endometrial dynamics in letrozole-treated versus natural cycles in patients undergoing controlled ovarian stimulation

    Directory of Open Access Journals (Sweden)

    Brunengraber Lisa N


    Full Text Available Abstract The objective of this study was to compare letrozole-stimulated cycles to natural cycles in 208 patients undergoing intrauterine insemination (IUI between July of 2004 and January of 2007. Group I (n = 47 received cycle monitoring only (natural group, Group II (n = 125 received letrozole 2.5 mg/day on cycle days three to seven, and Group III (n = 36 received letrozole 5 mg/day on cycle days three to seven. There were no differences between the groups in endometrial thickness or P4 on the day of hCG. Estradiol levels had higher variation in the second half of the follicular phase in both letrozole-treated groups compared to the control group. Estradiol per preovulatory follicle was similar in both letrozole cycles to that observed in the natural cycles. LH was lower on the day of hCG administration in the letrozole 2.5 mg/day group vs. the natural group. In summary, letrozole results in some minor changes in follicular, hormonal and endometrial dynamics compared to natural cycles. Increased folliculogenesis and pregnancy rates were observed in the letrozole-treated groups compared to the natural group. These findings need to be confirmed in larger, prospective studies.

  1. Follicular Dowling Degos disease: A rare variant of an evolving dermatosis

    Directory of Open Access Journals (Sweden)

    Saurabh Singh


    Full Text Available Dowling Degos disease is a rare, reticulate pigmentary disorder with variable phenotypic expression that manifests as hyperpigmented macules and reticulate pigmentary anomaly of the flexures. Many variants of this condition and its overlap with other reticulate pigmentary disorders have been reported in the literature. We present here two cases of DDD with follicular localization, both clinically and histologically. It was associated with ichthyosis vulgaris in one case. Follicular DDD is an uncommon variant of this evolving dermatosis. Our report supports the possible role for disordered follicular keratinisation in its pathogenesis.

  2. Dependence between sea surge, river flow and precipitation in south and west Britain

    Directory of Open Access Journals (Sweden)

    C. Svensson


    Full Text Available Estuaries around Great Britain may be at heightened risk of flooding because of the simultaneous occurrence of extreme sea surge and river flow, both of which may be caused by mid-latitude cyclones. A measure especially suited for extremes was employed to estimate dependence between river flow and sea surge. To assist in the interpretation of why flow-surge dependence occurs in some areas and not in others, the dependence between precipitation and surge and between precipitation and river flow was also studied. Case studies of the meteorological situations leading to high surges and/or river flows were also carried out. The present study concerns catchments draining to the south and west coasts of Great Britain. Statistically significant dependence between river flow and daily maximum sea surge may be found at catchments spread along most of this coastline. However, higher dependence is generally found in catchments in hilly areas with a southerly to westerly aspect. Here, precipitation in south-westerly airflow, which is generally the quadrant of prevailing winds, will be enhanced orographically as the first higher ground is encountered. The sloping catchments may respond quickly to the abundant rainfall and the flow peak may arrive in the estuary on the same day as a large sea surge is produced by the winds and low atmospheric pressure associated with the cyclone. There are three regions where flow-surge dependence is strong: the western part of the English south coast, southern Wales and around the Solway Firth. To reduce the influence of tide-surge interaction on the dependence analysis, the dependence between river flow and daily maximum surge occurring at high tide was estimated. The general pattern of areas with higher dependence is similar to that using the daily maximum surge. The dependence between river flow and daily maximum sea surge is often strongest when surge and flow occur on the same day. The west coast from Wales and

  3. The "Ram Effect": A "Non-Classical" Mechanism for Inducing LH Surges in Sheep. (United States)

    Fabre-Nys, Claude; Chanvallon, Audrey; Dupont, Joëlle; Lardic, Lionel; Lomet, Didier; Martinet, Stéphanie; Scaramuzzi, Rex J


    During spring sheep do not normally ovulate but exposure to a ram can induce ovulation. In some ewes an LH surge is induced immediately after exposure to a ram thus raising questions about the control of this precocious LH surge. Our first aim was to determine the plasma concentrations of oestradiol (E2) E2 in anoestrous ewes before and after the "ram effect" in ewes that had a "precocious" LH surge (starting within 6 hours), a "normal" surge (between 6 and 28h) and "late» surge (not detected by 56h). In another experiment we tested if a small increase in circulating E2 could induce an LH surge in anoestrus ewes. The concentration of E2 significantly was not different at the time of ram introduction among ewes with the three types of LH surge. "Precocious" LH surges were not preceded by a large increase in E2 unlike "normal" surges and small elevations of circulating E2 alone were unable to induce LH surges. These results show that the "precocious" LH surge was not the result of E2 positive feedback. Our second aim was to test if noradrenaline (NA) is involved in the LH response to the "ram effect". Using double labelling for Fos and tyrosine hydroxylase (TH) we showed that exposure of anoestrous ewes to a ram induced a higher density of cells positive for both in the A1 nucleus and the Locus Coeruleus complex compared to unstimulated controls. Finally, the administration by retrodialysis into the preoptic area, of NA increased the proportion of ewes with an LH response to ram odor whereas treatment with the α1 antagonist Prazosin decreased the LH pulse frequency and amplitude induced by a sexually active ram. Collectively these results suggest that in anoestrous ewes NA is involved in ram-induced LH secretion as observed in other induced ovulators.

  4. Zinc Oxide Surge Arresters and HVDC 125kV-upgrade 500kV Converter Stations (United States)

    Shirakawa, Shingo; Kobayashi, Takayuki; Matsushita, Yoshinao; Sakai, Takehisa; Suzuki, Hironori; Ozaki, Yuzo

    Gapless Metal (Zinc) Oxide Surge Arresters for a.c. systems contribute to the insulation co-ordination based on the suppression of lightning surges and switching surges. These gapless metal oxide surge arresters using ZnO elements are effective to HVDC systems. This paper describes basic characteristics of ZnO (zinc oxide) elements for d.c. systems and applications of gapless surge arresters to HVDC 125kV frequency converters, HVDC 250kV, upgrade HVDC 500kV converter stations, and HVDC 500kV cables of Japan through the experience of developments and applications of gapless metal oxide surge arresters.

  5. Trefoil factor 3 is required for differentiation of thyroid follicular cells and acts as a context-dependent tumor suppressor. (United States)

    Abols, A; Ducena, K; Andrejeva, D; Sadovska, L; Zandberga, E; Vilmanis, J; Narbuts, Z; Tars, J; Eglitis, J; Pirags, V; Line, A


    Trefoil factor 3 (TFF3) is overexpressed in a variety of solid epithelial cancers, where it has been shown to promote migration, invasion, proliferation, survival and angiogenesis. On the contrary, in the majority of thyroid tumors, it is downregulated, yet its role in the development of thyroid cancer remains unknown. Here we show that TFF3 exhibits strong cytoplasmic staining of normal thyroid follicular cells and colloid and the staining is increased in hyperfunctioning thyroid nodules, while it is decreased in all thyroid cancers of follicular cell origin. By meta-analysis of gene expression datasets, we found that in the thyroid cancer, conversely to the breast cancer, the expression of TFF3 mRNA was downregulated by estrogen signaling and confirmed this by treating thyroid cancer cells with estradiol. Forced expression of TFF3 in anaplastic thyroid cancer cells resulted in decreased cell proliferation, clonal spheroid formation and entry into the S phase. Furthermore, it induced acquisition of epithelial-like cell morphology and expression of the differentiation markers of thyroid follicular cells and transcription factors implicated in the thyroid morphogenesis and function. Taken together, this study provides the first evidence that TFF3 may act as a tumor suppressor or an oncogene depending on the cellular context.

  6. In vitro and in vivo studies reveal that hamster oocyte meiotic arrest is maintained only transiently by follicular fluid, but persistently by membrana/cumulus granulosa cell contact. (United States)

    Racowsky, C; Baldwin, K V


    Studies were carried out with the golden Syrian hamster to investigate the capacity of follicular fluid to maintain oocyte meiotic arrest and to determine the importance of cumulus-membrana granulosa cell contact in the regulation of meiotic status. The follicular fluid studies were conducted by cytological assessment of meiotic stage up to 6 hr after transferring cumulus-free oocytes into antra of explanted "host" follicles in vitro or into follicles of anesthetized animals prior to the gonadotropin surge at proestrus in vivo. The cumulus-membrana granulosa contact studies were undertaken with explanted follicles in which the oocyte-cumulus complex was dislodged from the underlying membrana granulosa, released into the antrum, and subsequently allowed to reestablish contact during 6 hr of incubation within the follicle. The extent of recontact of the dislodged complex with the underlying membrana granulosa was assessed visually at the end of incubation and was classified as close, moderate, or none. These various degrees of contact typically involved the following number of cumulus cells, as determined by serial sectioning of a representative sample of follicles after dislodgement and subsequent incubation: close, 32.7 +/- 1.78; moderate, 9.0 +/- 2.1; and no contact, 0. After 6 hr of incubation either in vitro or in vivo, few transferred oocytes remained at the germinal vesicle (GV) stage (18.8 +/- 8.7 and 17.3 +/- 4.0% GV, respectively). However, time course experiments revealed that meiotic resumption was significantly delayed in transferred oocytes compared with either liberated oocytes, spontaneously maturing oocytes, or follicle-enclosed oocytes induced to mature by luteinizing hormone in vitro (after 4 hr, transferred, 31.3 +/- 6.0% GV; liberated, 0% GV; follicle-enclosed, 0% GV; after 6 hr, 0% transferred oocytes exhibited a GV). In the dislodgement studies, after 6 hr of incubation, 26% of complexes reestablished close contact with the underlying membrana

  7. Hybrid simulation of metal oxide surge-arrester thermal behaviour

    Energy Technology Data Exchange (ETDEWEB)

    Huang, L.; Raghuveer, M.R. [Manitoba Univ., Winnipeg, MB (Canada). Dept. of Electrical and Computer Engineering


    A finite-difference-based technique for simulating the thermal behaviour of a metal oxide surge arrester (MOSA) was described. The improved hybrid thermal modelling technique was claimed to accurately represent heat-transfer modes. Fin theory was used to represent arrester sheds. The proposed model, which relies on simple measurements at the arrester terminals, yields the temporal variation of temperature in a MOSA in both the axial and radial direction. The thermal behaviour of a MOSA under steady-state and transient conditions can be simulated using such a model under different environmental conditions. The accuracy of the modelling technique was demonstrated experimentally by measurements conducted on an arrester. 15 refs., 7 figs.

  8. Designs for surge immunity in critical electronic facilities (United States)

    Roberts, Edward F., Jr.


    In recent years, Federal Aviation Administration (FAA) embarked on a program replacing older tube type electronic equipment with newer solid state equipment. This replacement program dramatically increased the susceptibility of the FAA's facilities to lightning related damages. The proposal is presented of techniques which may be employed to lessen the susceptibility of new FAA electronic facility designs to failures resulting from lightning related surges and transients as well as direct strikes. The general concept espoused is one of a consistent system approach employing both perimeter and internal protection. It compares the technique presently employed to reduce electronic noise with other techniques which reduce noise while lowering susceptibility to lightning related damage. It is anticipated that these techniques will be employed in the design of an Air Traffic Control Tower in a high isokeraunic area. This facility would be subjected to rigorous monitoring over a multi-year period to provide quantitative data hopefully supporting the advantage of this design.

  9. Designs for surge immunity in critical electronic facilities (United States)

    Roberts, Edward F., Jr.


    In recent years, Federal Aviation Administration (FAA) embarked on a program replacing older tube type electronic equipment with newer solid state equipment. This replacement program dramatically increased the susceptibility of the FAA's facilities to lightning related damages. The proposal is presented of techniques which may be employed to lessen the susceptibility of new FAA electronic facility designs to failures resulting from lightning related surges and transients as well as direct strikes. The general concept espoused is one of a consistent system approach employing both perimeter and internal protection. It compares the technique presently employed to reduce electronic noise with other techniques which reduce noise while lowering susceptibility to lightning related damage. It is anticipated that these techniques will be employed in the design of an Air Traffic Control Tower in a high isokeraunic area. This facility would be subjected to rigorous monitoring over a multi-year period to provide quantitative data hopefully supporting the advantage of this design.

  10. SAPS onset timing during substorms and the westward traveling surge (United States)

    Mishin, Evgeny, V.


    We present multispacecraft observations in the magnetosphere and conjugate ionosphere of the onset time of subauroral polarization streams (SAPS) and tens of keV ring current injections on the duskside in three individual substorms. This is probably the first unequivocal determination of the substorm SAPS onset timing. The time lag between the SAPS and substorm onsets is much shorter than the gradient-curvature drift time of ˜10 keV ions in the plasmasphere. It seemingly depends on the propagation time of substorm-injected plasma from the dipolarization onset region to the plasmasphere, as well as on the SAPS position. These observations suggest that fast onset SAPS and ring current injections are causally related to the two-loop system of the westward traveling surge.

  11. Recent Trends of Technology of Zinc-Oxide Surge Arrester for Electric Power System

    Energy Technology Data Exchange (ETDEWEB)

    Kim, S.S.; Kim, K.U.; Cho, H.G. [Korea Electrotechnology Research Institute (Korea); Park, T.G. [Changwon National University (Korea); Park, S.H. [KEPCO (Korea)


    Metal-oxide surge arresters were developed in the late 1970s, and were immediately recognized as significant breakthrough in over-voltage protection of power system. Work was continued throughout the world on the design, development and application of metal-oxide surge arresters. (author). 6 refs., 1 fig., 6 tabs.

  12. Validating the calculated reliability and availability in Dutch storm surge barriers (and other infrastructural works)

    NARCIS (Netherlands)

    Kleijn van Willigen, G.K.; Meerveld, H. van


    The reliability and availability of the Dutch storm surge barriers are calculated by probabilistic risk assessment and various underlying risk analysis methods. These calculations, however, focus on the numerical probability of the storm surge barrier functioning adequately, and the implementation o


    Energy Technology Data Exchange (ETDEWEB)

    Robert J. Mckee; Danny M. Deffenbaugh


    This annual progress report describes the second year's technical progress in a three-year program. This report summarizes what is known about internal flows as surge precursors in centrifugal compressors and focuses on accessing factors that affect pre-surge detection. An attempt is made in this analysis to identify and quantify factors concerning compressor design and operations that affect the detection of pre-surge conditions. This progress report presents results from recent laboratory tests conducted during the course of this second year. This project is co-funded by the Gas Machinery Research Council (GMRC) and by Siemens Energy and Automation (Siemens). The most recently available measured pre-surge internal flow data is parameterized to help identify factors that affect the indications that a compressor is approaching surge. Theoretical arguments are applied to access the factors that influence surge precursors and surge initiation in different centrifugal compressors. This work is considered a step in accessing the factors that affect the success or limitations of pre-surge detection in natural gas pipeline compressors.

  14. Role of exogenous estrogen in initiation of estrus and induction of an LH surge (United States)

    Among cattle the LH surge that causes ovulation occurs shortly after the onset of a spontaneous estrus. In addition an injection of 100 'g of GnRH can induce an LH surge capable of inducing ovulation. We hypothesized that different preovulatory estradiol profiles would result in different ovulator...

  15. Extreme storm surges: a comparative study of frequency analysis approaches

    Directory of Open Access Journals (Sweden)

    Y. Hamdi


    Full Text Available In France, nuclear facilities were designed to very low probabilities of failure. Nevertheless, exceptional climatic events have given rise to surges much larger than observations (outliers and had clearly illustrated the potential to underestimate the extreme water levels calculated with the current statistical methods. The objective of the present work is to conduct a comparative study of three approaches including the Annual Maxima (AM, the Peaks-Over Threshold (POT and the r-Largest Order Statistics (r-LOS. These methods are illustrated in a real analysis case study. All the data sets were screened for outliers. Non-parametric tests for randomness, homogeneity and stationarity of time series were used. The shape and scale parameters stability plots, the mean excess residual life plot and the stability of the standard errors of return levels were used to select optimal thresholds and r values for the POT and r-LOS method, respectively. The comparison of methods was based on: (i the uncertainty degrees, (ii the adequacy criteria and tests and (iii the visual inspection. It was found that the r-LOS and POT methods have reduced the uncertainty on the distributions parameters and return level estimates and have systematically shown values of the 100 and 500 yr return levels smaller than those estimated with the AM method. Results have also shown that none of the compared methods has allowed a good fitting at the right tail of the distribution in the presence of outliers. As a perspective, the use of historical information was proposed in order to increase the representativity of outliers in data sets. Findings are of practical relevance not only to nuclear energy operators in France, for applications in storm surge hazard analysis and flood management, but also for the optimal planning and design of facilities to withstand extreme environmental conditions, with an appropriate level of risk.

  16. Extreme storm surges: a comparative study of frequency analysis approaches (United States)

    Hamdi, Y.; Bardet, L.; Duluc, C.-M.; Rebour, V.


    In France, nuclear facilities were designed around very low probabilities of failure. Nevertheless, some extreme climatic events have given rise to exceptional observed surges (outliers) much larger than other observations, and have clearly illustrated the potential to underestimate the extreme water levels calculated with the current statistical methods. The objective of the present work is to conduct a comparative study of three approaches to extreme value analysis, including the annual maxima (AM), the peaks-over-threshold (POT) and the r-largest order statistics (r-LOS). These methods are illustrated in a real analysis case study. All data sets were screened for outliers. Non-parametric tests for randomness, homogeneity and stationarity of time series were used. The shape and scale parameter stability plots, the mean excess residual life plot and the stability of the standard errors of return levels were used to select optimal thresholds and r values for the POT and r-LOS method, respectively. The comparison of methods was based on (i) the uncertainty degrees, (ii) the adequacy criteria and tests, and (iii) the visual inspection. It was found that the r-LOS and POT methods have reduced the uncertainty on the distribution parameters and return level estimates and have systematically shown values of the 100 and 500-year return levels smaller than those estimated with the AM method. Results have also shown that none of the compared methods has allowed a good fit at the right tail of the distribution in the presence of outliers. As a perspective, the use of historical information was proposed in order to increase the representativeness of outliers in data sets. Findings are of practical relevance, not only to nuclear energy operators in France, for applications in storm surge hazard analysis and flood management, but also for the optimal planning and design of facilities to withstand extreme environmental conditions, with an appropriate level of risk.

  17. Immunohistochemical patterns of follicular dendritic cell meshwork and Ki-67 in small B-cell lymphomas

    Institute of Scientific and Technical Information of China (English)



    Objective To identify the immunohistochemical patterns of follicular dendritic cell(FDC)meshwork and Ki-67labeling index in small B-cell lymphomas(SBLs) and their significance in differential diagnosis.Methods

  18. Regulation of B Cell to Plasma Cell Transition within the Follicular B Cell Response. (United States)

    Nera, K-P; Kyläniemi, M K; Lassila, O


    Persistent humoral immunity depends on the follicular B cell response and on the generation of somatically mutated high-affinity plasma cells and memory B cells. Upon activation by an antigen, cognately activated follicular B cells and follicular T helper (TFH ) cells initiate germinal centre (GC) reaction during which high-affinity effector cells are generated. The differentiation of activated follicular B cells into plasma cells and memory B cells is guided by complex selection events, both at the cellular and molecular level. The transition of B cell into a plasma cell during the GC response involves alterations in the microenvironment and developmental state of the cell, which are guided by cell-extrinsic signals. The developmental cell fate decisions in response to these signals are coordinated by cell-intrinsic gene regulatory network functioning at epigenetic, transcriptional and post-transcriptional levels.

  19. Population Pharmacokinetics of Ofatumumab in Patients With Chronic Lymphocytic Leukemia, Follicular Lymphoma, and Rheumatoid Arthritis

    DEFF Research Database (Denmark)

    Struemper, Herbert; Sale, Mark; Patel, Bela R;


    Ofatumumab is a human monoclonal antibody directed at CD20 approved for treatment of chronic lymphocytic leukemia. The population pharmacokinetics of intravenous ofatumumab were characterized in patients with relapsed/refractory chronic lymphocytic leukemia, relapsed/refractory follicular lymphoma...

  20. Preliminary findings suggest hidradenitis suppurativa may be due to defective follicular support

    DEFF Research Database (Denmark)

    Danby, F W; Jemec, G B E; Marsch, W Ch


    BACKGROUND: The initial pathology in hidradenitis suppurativa (HS)/acne inversa takes place in the folliculopilosebaceous unit (FPSU) and its surrounding tissue. The process involves follicular hyperkeratosis, inflammation and perifolliculitis. Identification of the exact origin of inflammation may...

  1. Insular carcinoma: a distinct de novo entity among follicular carcinomas of the thyroid gland. (United States)

    Pilotti, S; Collini, P; Mariani, L; Placucci, M; Bongarzone, I; Vigneri, P; Cipriani, S; Falcetta, F; Miceli, R; Pierotti, M A; Rilke, F


    We reclassified 720 nonmedullary invasive thyroid carcinomas diagnosed and treated between 1975 and 1993. Twenty-seven cases met the criteria of insular carcinoma and 29 cases those of widely invasive follicular carcinoma. Comparison of these histotypes with respect to pathologic stage and overall, relative, and visceral metastasis-free survival showed a significant association between histotype and pT and pN categories. In particular, pT4 (p AAA transversion at codon 61 of the N-RAS gene in insular carcinoma. These findings suggest that insular carcinoma represents a de novo entity distinct from widely invasive follicular carcinoma, that widely invasive follicular carcinoma has biologic characteristics more consistent with poorly differentiated than well-differentiated carcinomas, and that both insular carcinoma and widely invasive follicular carcinoma share similar molecular alterations.

  2. Identifying surging glaciers in the Central Karakoram for improved climate change impact assessment (United States)

    Paul, Frank; Bolch, Tobias; Mölg, Nico; Rastner, Philipp


    Several recent studies have investigated glacier changes in the Karakoram mountain range, a region where glaciers behave differently (mass gain and advancing tongues) compared to most other regions in the world. Attribution of this behaviour to climate change is challenging, as many glaciers in the Karakoram are of surge type and have actively surged in the recent past. The measured changes in length, area, volume or velocity in this region are thus depending on the time-period analysed and include non-climatic components. Hence, a proper analysis of climate change impacts on glaciers in this region requires a separation of the surging from the non-surging glaciers. This is challenging as the former often lack the typical surface characteristics such as looped moraines (e.g. when they are steep and small) and/or they merge (during a surge) with a larger non-surging glacier and create looped moraines on its surface. By analysing time series of satellite images that are available since 1961, the heterogeneous behaviour of glaciers in the Karakoram can be revealed. In this study, we have analysed changes in glacier terminus positions in the Karakoram over different time periods from 1961 to 2014 for several hundred glaciers using Corona KH-4 and KH-4B, Hexagon KH-9, Terra ASTER, and Landsat MSS, TM, ETM+ and OLI satellite data. For the last 15 years, high-speed animations of image time-series reveal details of glacier flow and surge dynamics that are otherwise difficult to detect. For example, several of the larger glaciers with surging tributaries (e.g. Panmah, Sarpo Laggo, Skamri, K2 glacier) are stationary and downwasting despite the mass contributions from the surging glaciers. The analysis of the entire time series reveals a complex pattern of changes through time with retreating, advancing, surging and stationary glaciers that are partly regionally clustered. While most of the non-surging glaciers show only small changes in terminus position (±100 m or less

  3. Artificial Neural Network forecasting of storm surge water levels at major estuarine ports to supplement national tide-surge models and improve port resilience planning (United States)

    French, Jon; Mawdsley, Robert; Fujiyama, Taku; Achuthan, Kamal


    Effective prediction of tidal storm surge is of considerable importance for operators of major ports, since much of their infrastructure is necessarily located close to sea level. Storm surge inundation can damage critical elements of this infrastructure and significantly disrupt port operations and downstream supply chains. The risk of surge inundation is typically approached using extreme value analysis, while short-term forecasting generally relies on coastal shelf-scale tide and surge models. However, extreme value analysis does not provide information on the duration of a surge event and can be sensitive to the assumptions made and the historic data available. Also, whilst regional tide and surge models perform well along open coasts, their fairly coarse spatial resolution means that they do not always provide accurate predictions for estuarine ports. As part of a NERC Environmental Risks to Infrastructure Innovation Programme project, we have developed a tool that is specifically designed to forecast the North Sea storm surges on major ports along the east coast of the UK. Of particular interest is the Port of Immingham, Humber estuary, which handles the largest volume of bulk cargo in the UK including major flows of coal and biomass for power generation. A tidal surge in December 2013, with an estimated return period of 760 years, partly flooded the port, damaged infrastructure and disrupted operations for several weeks. This and other recent surge events highlight the need for additional tools to supplement the national UK Storm Tide Warning Service. Port operators are also keen to have access to less computationally expensive forecasting tools for scenario planning and to improve their resilience to actual events. In this paper, we demonstrate the potential of machine learning methods based on Artificial Neural Networks (ANNs) to generate accurate short-term forecasts of extreme water levels at estuarine North Sea ports such as Immingham. An ANN is

  4. Directional Storm Surge in Enclosed Seas: The Red Sea, the Adriatic, and Venice

    Directory of Open Access Journals (Sweden)

    Carl Drews


    Full Text Available Storm surge is dependent on wind direction, with maximum surge heights occurring when strong winds blow onshore. It is less obvious what happens when a port city is situated at the end of a long narrow gulf, like Venice at the northwestern end of the Adriatic Sea. Does the narrow marine approach to the port city limit the dangerous wind direction to a span of only a few degrees? This modeling study shows that the response in surge height to wind direction is a sinusoidal curve for port cities at the end of a long inlet, as well as for cities exposed along a straight coastline. Surge height depends on the cosine of the angle between the wind direction and the major axis of the narrow gulf. There is no special protection from storm surge afforded by a narrow ocean-going approach to a port city.

  5. Quantification of Sediment Transport During Glacier Surges and its Impact on Landform Architecture

    DEFF Research Database (Denmark)

    Kjær, Kurt H.; Schomacker, Anders; Korsgaard, Niels Jákup

    Eos Trans. AGU, 89(53), Fall Meet. Suppl., Abstract C23A-0580 Multi-temporal DEMs (Digital Elevation Models) of glaciers and ice streams have successfully been used for extraction of changes in ice volume over time. In this study, we analysed DEMs of the Brúarjökull glacier forefield (Iceland......) for 1945, prior to the last surge in 1964, and for 2003 in order to assess the effect of the surge on the sediment architecture in the forefield. The pre- and post-surge DEMs allow direct quantification of the sediment volumes that were re-distributed in the forefield by the surging ice mass in 1964...... margin, where the impact of four surges is evident. Thus, the landscape at Brúarjökull is a product of multiple generations of superimposed landforms associated with extensive sediment transport through subglacial deformation....

  6. Determining Storm Surge Return Periods: The Use of Evidence of Historic Events

    DEFF Research Database (Denmark)

    Madsen, Kristine S.; Sørensen, Carlo Sass; Schmith, Torben

    Storm surges are a major concern for many coastal communities, and rising levels of surges is a key concern in relation to climate change. The sea level of a statistical 100-year or 1000-year storm surge event and similar statistical measures are used for spatial planning and emergency preparedness....... These statistics are very sensitive to the assessments of past events, and to future sea level change. The probability of a major storm surge from the Baltic Sea hitting the Copenhagen metropolitan area is officially determined by the Danish Coastal Authority based on tide gauge records. We have a long history......, but with the revised statistics using historic evidence, much larger events can be expected. Further, we assess the very large impact of sea level rise on the storm surge statistics. As an example, according to the official statistics of southern Copenhagen, the flooding of a present day 100 year event...

  7. Multivariate extreme value analysis of storm surges in SCS on peak over threshold method

    Directory of Open Access Journals (Sweden)

    Y. Luo


    Full Text Available We use a novel statistical approach-MGPD to analyze the joint probability distribution of storm surge events at two sites and present a warning method for storm surges at two adjacent positions in Beibu Gulf, using the sufficiently long field data on surge levels at two sites. The methodology also develops the procedure of application of MGPD, which includes joint threshold and Monte Carlo simulation, to handle multivariate extreme values analysis. By comparing the simulation result with analytic solution, it is shown that the relative error of the Monte Carlo simulation is less than 8.6 %. By running MGPD model based on long data at Beihai and Dongfang, the simulated potential surge results can be employed in storm surge warnings of Beihai and joint extreme water level predictions of two sites.

  8. Impact of Exogenous Gonadotropin Stimulation on Circulatory and Follicular Fluid Cytokine Profiles

    Directory of Open Access Journals (Sweden)

    N. Ellissa Baskind


    Full Text Available Background. The natural cycle is the prototype to which we aspire to emulate in assisted reproduction techniques. Increasing evidence is emerging that controlled ovarian hyperstimulation (COH with exogenous gonadotropins may be detrimental to oogenesis, embryo quality, and endometrial receptivity. This research aimed at assessing the impact of COH on the intrafollicular milieu by comparing follicular fluid (FF cytokine profiles during stimulated in vitro fertilization (IVF and modified natural cycle (MNC IVF. Methods. Ten women undergoing COH IVF and 10 matched women undergoing MNC IVF were recruited for this pilot study. 40 FF cytokine concentrations from individual follicles and plasma were measured by fluid-phase multiplex immunoassay. Demographic/cycle/cytokine data were compared and correlations between cytokines were computed. Results. No significant differences were found between COH and MNC groups for patient and cycle demographics, including outcome. Overall mean FF cytokine levels were higher in the MNC group for 29/40 cytokines, significantly so for leukaemia inhibitory factor and stromal cell-derived factor-1α. Furthermore, FF MNC cytokine correlations were significantly stronger than for COH data. Conclusions. These findings suggest that COH perturbs intrafollicular cytokine networks, in terms of both cytokine levels and their interrelationships. This may impact oocyte maturation/fertilization and embryo developmental competence.

  9. Postnatal lineage mapping of follicular melanocytes with the Tyr::CreER(T) (2) transgene. (United States)

    Harris, Melissa L; Pavan, William J


    One of the main advantages of using inducible and conditional transgenes to study pigment cell biology is that they allow for genetic manipulation within melanocytes after roles in general neural crest or melanoblast development have been fulfilled. Specifically, we focus here on the ability of the Tyr::CreER(T) (2) transgenic line to alter genes within follicular melanocytes postnatally. Using the Gt(ROSA)26Sor(tm1sor) reporter allele, we present in detail the expression and activity of Tyr::CreER(T) (2) when induced during hair morphogenesis and adult hair cycling. We find that despite similarities in expression pattern to endogenous TYR, Tyr::CreER(T) (2) is effective at targeting both undifferentiated and differentiated melanocytes within the hair follicle. We also find that Tyr::CreER(T) (2) provides the highest levels of recombination when induced during the early phases of hair growth. In conclusion, the descriptions provided here will guide future analyses of gene function within the melanocyte system of the hair follicle when using this Tyr::CreER(T) (2) transgene.

  10. Ethnic differences in skin physiology, hair follicle morphology and follicular penetration


    Luther, Natalie


    There is increasing evidence that different ethnic groups exhibit varieties in skin physiological parameters and penetration behaviour, although data available are inconsistent. Likewise variations in hair follicle morphology have been described although its influence on the follicular penetration process has not been investigated until now. Therefore, the aim of the present study was to investigate skin physiological parameters, the hair follicle morphology and the follicular and interce...

  11. A new dynamical index for classification of cold surge types over East Asia (United States)

    Park, Tae-Won; Ho, Chang-Hoi; Jeong, Jee-Hoon; Heo, Jin-Woo; Deng, Yi


    The cold surges over East Asia can be classified into wave-train type and blocking type according to their dynamic origins. In the present study, two dynamic indices are proposed to objectively identify cold surge types using potential temperature ( θ) on the dynamic tropopause at 2-potential vorticity units (2-PVU) surface. The two indices are designed to represent primary characteristics of the two types of cold surge. The wave-train index ( WI) is defined as a difference of anomalous θ on the 2-PVU surface between the western North Pacific and northeast China, which captures a southward (northward) intrusion of cold (warm) air mass related to the trough-ridge pattern. The blocking index ( BI) is defined as a difference of anomalous θ between the subarctic region and northeast China, which indicates air mass overturning related to a reversal of the usual meridional θ gradient commonly observed in the occurrence of blocking type cold surge. Composite analyses based on the distribution of the WI and BI clearly demonstrate the dynamic evolutions of corresponding cold surge types. The wave-train cold surge is associated with a southeastward expansion of the Siberian High and northerly wind near surface, which is caused by growing baroclinic waves. During the blocking cold surge, a geopotential height dipole indicating the subarctic blocking and deepening of East Asian coastal trough induces a southward expansion of the Siberian High and northeasterly wind. Compared to the wave-train type, the blocking cold surge exhibits a longer duration and stronger intensity. In the new framework of these dynamic indices, we can detect a third type of cold surge when both the wave-train and the blocking occur together. In addition, we can exclude the events that do not have the essential features of the upper tropospheric disturbances or the subarctic anticyclonic circulation, which are responsible for cold surge occurrence, using the new indices.

  12. Global reconstructed daily surge levels from the 20th Century Reanalysis (1871-2010) (United States)

    Cid, Alba; Camus, Paula; Castanedo, Sonia; Méndez, Fernando J.; Medina, Raúl


    Studying the effect of global patterns of wind and pressure gradients on the sea level variation (storm surge) is a key issue in understanding the recent climate change effect on the dynamical state of the ocean. The analysis of the spatial and temporal variability of storm surges from observations is a difficult task to accomplish since observations are not homogeneous in time, scarce in space, and moreover, their temporal coverage is limited. A recent global surge database developed by AVISO (DAC, Dynamic Atmospheric Correction) fulfilled the lack of data in terms of spatial coverage, but not regarding time extent, since it only includes the last two decades (1992-2014). In this work, we use the 20th Century Reanalysis V2 (20CR), which spans the years 1871 to 2010, to statistically reconstruct daily maximum surge levels at a global scale. A multivariate linear regression model is fitted between daily mean ERA-interim sea level pressure fields and daily maximum surge levels from DAC. Following, the statistical model is used to reconstruct daily surges using mean sea level pressure fields from 20CR. The verification of the statistical model shows good agreements between DAC levels and the reconstructed surge levels from the 20CR. The validation of the reconstructed surge with tide gauges, distributed throughout the domain, shows good accuracy both in terms of high correlations and small errors. A time series comparison is also depicted at specific tide gauges for the beginning of the 20th century, showing a high concordance. Therefore, this work provides to the scientific community, a daily database of maximum surge levels; which correspond to an extension of the DAC database, from 1871 to 2010. This database can be used to improve the knowledge on historical storm surge conditions, allowing the study of their temporal and spatial variability.

  13. Spatial distribution of erosion and deposition during a glacier surge: Brúarjökull, Iceland (United States)

    Korsgaard, Niels J.; Schomacker, Anders; Benediktsson, Ívar Örn; Larsen, Nicolaj K.; Ingólfsson, Ólafur; Kjær, Kurt H.


    Time-series of digital elevation models (DEMs) of the forefield of the Brúarjökull surge-type glacier in Iceland were used to quantify the volume of material that was mobilized by the 1963-1964 surge. The DEMs were produced by stereophotogrammetry on aerial photographs from before the surge (1961) and after (1988 and 2003). The analysis was performed on two DEMs of Difference (DoDs), i.e., a 1961-2003 DoD documenting the impact of the surge and a 1988-2003 DoD documenting the post-surge modification of the juvenile surging glacier landsystem. Combined with a digital geomorphological map, the DoDs allow us to quantify the impact of the surge on a landsystem scale down to individual landforms. A total of 34.2 ± 11.3 × 106 m3 of material was mobilized in the 30.7-km2 study area as a result of the most recent surge event. Of these, 17.4 ± 6.6 × 106 m3 of the material were eroded and 16.8 ± 4.7 × 106 m3 were deposited. More than half of the deposited volume was ice-cored landforms. This study demonstrates that although the total mobilized mass volume is high, the net volume gain of ice and sediment deposited as landforms in the forefield caused by the surge is low. Furthermore, deposition of new dead-ice from the 1963-1964 surge constitutes as much as 64% of the volume gain in the forefield. The 1988-2003 DoD is used to quantify the melt-out of this dead-ice and other paraglacial modification of the recently deglaciated forefield of Brúarjökull.

  14. Comparison of PUFA profiles in the blood and in follicular fluid and its association with follicular dynamics after PGF2α induced luteolysis in dairy cows

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    Branko Atanasov


    Full Text Available The objectives of the present study were to examine the fatty acid (FA profiles in serum and in the follicular fluid (FF and the association between polyunsaturated fatty acid level (PUFA and follicular growth dynamics following induced luteolysis in dairy cows. A total of 29 dairy cows (CL>25mm, follicle≈15mm at d0 (start of the experiment were submitted to ultrasound guided transvaginal follicular aspiration for FF collection from the largest follicle and were injected with 500 μg of cloprostenol. The cows were subdivided into Group A1 (n=11 and Group A2 (n=8 resuming follicular growth either from a secondary follicle less than or larger than 8.5mm, respectively, present at the moment of aspiration and Group A0 (n=10 not resuming follicular growth. Follicular development was monitored daily by ultrasonography until the next dominant follicle reached ≈15mm and was subsequently punctured in Group A1 and A2 (d1. Serum and FF samples for FA determination were taken at d0 from all cows and at d1 in Group A1 and A2. No differences were observed between the FA profile in serum nor in FF between sampling days. Regarding the PUFA levels, the serum linoleic acid (C18:2n6 levels at d0 and d1 were significantly higher than in FF, while alpha linolenic acid (C18:3n3 was lower in the serum than in FF, both at d0 and d1. At d0, a tendency for negative correlation between serum and the FF C18:2n6 with subsequent daily follicular growth rate was observed, while, at d1 there was a strong negative correlation between the serum C18:2n6 and daily growth rate (r=-0.71; p=0.0006. The present study revealed similarities of the FA profiles in the serum and in the FF and association between serum and FF PUFA content with the follicular dynamics after induced luteolysis.

  15. Storm surge and wave simulations in the Gulf of Mexico using a consistent drag relation for atmospheric and storm surge models

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    D. Vatvani


    Full Text Available To simulate winds and water levels, numerical weather prediction (NWP and storm surge models generally use the traditional bulk relation for wind stress, which is characterized by a wind drag coefficient. A still commonly used drag coefficient in those models, some of them were developed in the past, is based on a relation, according to which the magnitude of the coefficient is either constant or increases monotonically with increasing surface wind speed (Bender, 2007; Kim et al., 2008; Kohno and Higaki, 2006. The NWP and surge models are often tuned independently from each other in order to obtain good results. Observations have indicated that the magnitude of the drag coefficient levels off at a wind speed of about 30 m s−1, and then decreases with further increase of the wind speed. Above a wind speed of approximately 30 m s−1, the stress above the air-sea interface starts to saturate. To represent the reducing and levelling off of the drag coefficient, the original Charnock drag formulation has been extended with a correction term.

    In line with the above, the Delft3D storm surge model is tested using both Charnock's and improved Makin's wind drag parameterization to evaluate the improvements on the storm surge model results, with and without inclusion of the wave effects. The effect of waves on storm surge is included by simultaneously simulating waves with the SWAN model on identical model grids in a coupled mode. However, the results presented here will focus on the storm surge results that include the wave effects.

    The runs were carried out in the Gulf of Mexico for Katrina and Ivan hurricane events. The storm surge model was initially forced with H*wind data (Powell et al., 2010 to test the effect of the Makin's wind drag parameterization on the storm surge model separately. The computed wind, water levels and waves are subsequently compared with observation data. Based on the good

  16. Sex of bovine embryos may be related to mothers' preovulatory follicular testosterone. (United States)

    Grant, V J; Irwin, R J; Standley, N T; Shelling, A N; Chamley, L W


    Although the sex of the offspring in mammals is commonly viewed as a matter of chance (depending on whether an X or a Y chromosome-bearing spermatozoon reaches the ovum first), evolutionary biologists have shown that offspring sex ratios are often significantly related to maternal dominance, a characteristic that has been shown to be linked to testosterone in female mammals, including humans. Hence, we hypothesized that variations in female testosterone might be related to reproductive mechanisms associated with sex determination, with higher levels of follicular testosterone being associated with a greater likelihood of conceiving a male. To investigate this hypothesis we collected follicular fluid and cumulus-oocyte complexes from bovine antral follicles. Individual matched samples of follicular fluid were assayed for testosterone, whereas the oocytes were matured, fertilized, and cultured in vitro. The resultant embryos were sexed by PCR. The level of testosterone in the follicular fluid was then compared with sex of the embryo (n = 171). Results showed that follicular testosterone levels were significantly higher for subsequently male embryos (Mann-Whitney U = 2823; P [one-tailed] = 0.016). When we excluded embryos from follicles in which the estradiol-to-testosterone ratio was more than 1 (leaving a sample size of 135), the same result held (Mann-Whitney U = 1667; P [one-tailed] = 0.009). Thus, bovine ova that developed in follicular fluid with high concentrations of testosterone in vivo were significantly more likely to be fertilized by Y chromosome-bearing spermatozoa.

  17. MicroRNA Mediating Networks in Granulosa Cells Associated with Ovarian Follicular Development (United States)

    Zhang, Baoyun; Chen, Long; Feng, Guangde; Xiang, Wei; Zhang, Ke; Chu, Mingxing


    Ovaries, which provide a place for follicular development and oocyte maturation, are important organs in female mammals. Follicular development is complicated physiological progress mediated by various regulatory factors including microRNAs (miRNAs). To demonstrate the role of miRNAs in follicular development, this study analyzed the expression patterns of miRNAs in granulosa cells through investigating three previous datasets generated by Illumina miRNA deep sequencing. Furthermore, via bioinformatic analyses, we dissected the associated functional networks of the observed significant miRNAs, in terms of interacting with signal pathways and transcription factors. During the growth and selection of dominant follicles, 15 dysregulated miRNAs and 139 associated pathways were screened out. In comparison of different styles of follicles, 7 commonly abundant miRNAs and 195 pathways, as well as 10 differentially expressed miRNAs and 117 pathways in dominant follicles in comparison with subordinate follicles, were collected. Furthermore, SMAD2 was identified as a hub factor in regulating follicular development. The regulation of miR-26a/b on smad2 messenger RNA has been further testified by real time PCR. In conclusion, we established functional networks which play critical roles in follicular development including pivotal miRNAs, pathways, and transcription factors, which contributed to the further investigation about miRNAs associated with mammalian follicular development.

  18. An intra-thoracic follicular carcinoma of thyroid: An uncommon presentation. (United States)

    Kant, Surya; Srivastava, Anand; Kumar, Rahul; Verma, Ajay Kumar; Mishra, Anand Kumar; Husain, Nuzhat


    Follicular carcinoma of thyroid is the second most common type of carcinoma of thyroid, and it may metastasize to bone, lung, brain, and skin. However, the initial presentation of follicular carcinoma of the thyroid as a large intrathoracic mass without any symptoms of thyroid gland enlargement and dysfunction is very rare. We hereby report a case of a 50-year-old male who presented with chief complaints of chest and low back pain. Preliminary evaluation led to the provisional diagnosis of left-sided intrathoracic mass with vertebral metastasis which was suspected to be a case of bronchogenic carcinoma with distant metastasis. Surprisingly, transthoracic biopsy and histopathology revealed metastasis from follicular carcinoma of thyroid. This prompted us for a retrograde evaluation for a primary thyroid malignancy for which an ultrasound and contrast enhanced computed tomography (CECT) of the neck was done which confirmed the presence of a solitary thyroid nodule. Ultrasonography-guided fine-needle aspiration cytology of the nodule revealed follicular carcinoma of thyroid. Histopathological evaluation subsequent to total thyroidectomy revealed follicular carcinoma thyroid, further confirming the diagnosis. The patient was then referred to Department of Nuclear Medicine and Radiotherapy for radionuclide ablation and chemotherapy. We chose to report this case because of its rare presentation as a large intrathoracic mass and the retrograde diagnosis of follicular carcinoma of thyroid. To the best of our knowledge, this is the first report of such a rare case.

  19. Age and body size of captive hawksbill turtles at the onset of follicular development. (United States)

    Kawazu, Isao; Kino, Masakatsu; Maeda, Konomi; Teruya, Hideshi


    The aim of this study was to record the age and body size of 23 captive female hawksbill turtles at the onset of follicular development. The age, straight carapace length (SCL), and body mass (BM) of the turtles were recorded between 2006 and 2014 at follicular development (determined via ultrasonography) these parameters were 17.7 ± 1.7 years (range: 13-20 years), 77.7 ± 3.3 cm (73.3-83.5 cm), and 61.1 ± 8.0 kg (48.2-76.1 kg), respectively. When the year of the onset of follicular development was designated year 0, the increase in SCL in years -7-0 and 0-3 averaged 2.2 cm and 1.0 cm, respectively. Correspondingly, the increase in BM in years -7-0 and 0-3 averaged 5.0 kg and 2.2 kg, respectively. This is the first study to report the age and body size of captive female hawksbill turtles at the onset of follicular development, which indicates the beginning of sexual maturation. The reduction in growth after follicular development suggests that at the onset of sexual maturation, female hawksbills may utilize energy for follicular development rather than growth.

  20. FDG PET/CT predictive role in follicular lymphoma

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    Lopci, Egesta [University Hospital S. Orsola-Malpighi Alma Mater Studiorum, Nuclear Medicine Department, Bologna (Italy); IRCCS, Humanitas (Rozzano), Nuclear Medicine Department, Milan (Italy); Zanoni, Lucia; Fonti, Cristina; Santi, Ivan; Fanti, Stefano [University Hospital S. Orsola-Malpighi Alma Mater Studiorum, Nuclear Medicine Department, Bologna (Italy); Chiti, Arturo [IRCCS, Humanitas (Rozzano), Nuclear Medicine Department, Milan (Italy); Zinzani, Pier Luigi [University Hospital S. Orsola, Department of Hematology ' ' L. Seragnoli' ' , Bologna (Italy)


    We present findings concerning {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET) at end-treatment evaluation in follicular lymphoma (FL) in order to establish possible predictive factors for progression-free survival (PFS) and patient outcome. We retrospectively analysed data from 91 consecutive FL patients (M:F = 51:40, mean age 61) referred to our PET Unit at therapy completion: 38 with an indolent form (grade 1-2) and 53 with an aggressive FL (grade 3a and b) according to the World Health Organization (WHO) classification. A total of 148 FDG PET/CT scans were analysed and findings reported as positive or negative for disease. The overall response to treatment was assessed according to the revised International Workshop Criteria (IWC). The final outcome was defined as remission or disease by taking clinical, instrumental and histological data as standards of reference, with a mean follow-up period of 3 years (range 1-8). A statistical analysis was performed with respect to PFS and patient outcome for FDG PET result, tumour grading, Follicular Lymphoma International Prognostic Index (FLIPI), disease stage and number of relapses, on uni- and multivariate analyses, with p < 0.05 considered as significant. Overall patients presented a mean PFS of 35 months (range 3-86), with a relapse rate of 42%. At final outcome, remission was achieved in 67 of 91 patients (74%). Of the different predictive factors, only FDG PET result significantly correlated with patient outcome (p = 0.0002). PET/CT performance at the end of treatment was as follows: 100% sensitivity, 99% specificity, 89% positive predictive value and 100% negative predictive value. The Kaplan-Meier analysis demonstrated a statistically significant correlation with PFS for FDG PET (p < 0.0001), FLIPI score (0-1 versus {>=}2) (p = 0.0451) and number of relapses (none versus {>=}1) (p = 0.0058). These findings were confirmed at the univariate analysis, whereas at the multivariate analysis only

  1. [Follicular bronchiolitis: report of 3 cases and literature review]. (United States)

    Dai, J; Cai, H R; Li, Y; Meng, F Q; Wu, J Q


    Objective: To improve understanding of the characteristics of follicular bronchiolitis(FB). Methods: The clinical data of 3 patients with FB confirmed by thoracoscopic lung biopsy were retrospectively analyzed. A literature search was performed with "follicular bronchiolitis" as the key word in China Knowledge Resource Integrated Database, Wanfang and PubMed, Ovid Database. The time interval was from January 1947 to December 2015. Related articles of FB were retrieved and the clinical, radiographic characteristics and prognosis were analyzed. Results: Among the 3 patients, 1 was male and 2 were female, aging 32-55 years. Two patients were asymptomatic, and 1 patient presented with fever, cough and dyspnea. Two patients showed normal pulmonary ventilatory function with decreased diffusive function, and 1 patient showed normal pulmonary function. The predominant HRCT findings were bilateral multiple small nodules and cystic opacities, patchy ground-glass opacities, reticular opacities and traction bronchiectasis. The pathological examination by thoracoscopic biopsy revealed bronchiolar and peribronchiolar lymphoid follicles. All patients were treated with corticosteroids, with 2 patients receiving immunosuppressants. Follow-up HRCT after 1-2 months showed no improvement, and further follow-up HRCT after 2-4 years revealed no change in 2 patients while the other patient had increased pulmonary nodules and cystic opacities. Seventeen articles concerning FB with complete records were included in the literature review. A total of 64 patients were reported in these articles. The typical images were bilateral multiple small nodules and ground-glass opacities, reticular opacities, and cystic opacities. The majority of patients improved after treatment of corticosteroids and (or) immunosuppressants. But our 3 cases showed no improvement. Conclusions: FB is a rare small airway disease which has non-specific clinical manifestations and pulmonary function. The most common

  2. Quantification of Sediment Transport During Glacier Surges and its Impact on Landform Architecture (United States)

    Kjaer, K. H.; Schomacker, A.; Korsgaard, N. J.; Benediktsson, I. O.


    Multi-temporal DEMs (Digital Elevation Models) of glaciers and ice streams have successfully been used for extraction of changes in ice volume over time. In this study, we analysed DEMs of the Brúarjökull glacier forefield (Iceland) for 1945, prior to the last surge in 1964, and for 2003 in order to assess the effect of the surge on the sediment architecture in the forefield. The pre- and post-surge DEMs allow direct quantification of the sediment volumes that were re-distributed in the forefield by the surging ice mass in 1964. The surge-type glacier Brúarjökull has experienced six surges during the last four centuries; these are the largest surges known to have occurred in Iceland. During the most recent surge in 1963-64, the glacier advanced 8 km over a period of c. 3 months with a maximum ice flow velocity of 5 m/hr, and 700 km3 of ice were moved downglacier. The continued recession of Brúarjökull since the 1963-64 surge reveals a young landscape consisting of widely spaced and elongated bedrock hills interspaced with shallow sedimentary basins. The majority of the forefield is covered with a basal till sheet or glaciofluvial outwash fans. Mapping of the sediment thickness in the glacier forefield shows higher accumulation along ice marginal positions related to wedge formation during extremely rapid ice flow. Fast flow was sustained by overpressurized water causing sediment-bedrock decoupling beneath a thick sediment sequence that was coupled to the glacier. Elevation differences between the terrain surface in 1945 and 2003 confirm this scenario as huge quantities of sediment was eroded, deformed and transported during the last surge event. On the scale of individual landforms, it appears for a drumlin surface that is has been lowered 20 m from 1945-2003. Dead-ice melting can explain roughly 8 m of this lowering. Thus, the drumlin must have experienced 12 m of subglacial erosion during the 1964 surge. The imprint of at least four landform generations is

  3. Follicular targeting--a promising tool in selective dermatotherapy. (United States)

    Vogt, Annika; Mandt, Nathalie; Lademann, Juergen; Schaefer, Hans; Blume-Peytavi, Ulrike


    The penetration of topically applied compounds varies considerably in the different regions of the human body. The presence of hair follicles significantly contributes to this effect by an increase in surface area and a disruption of the epidermal barrier towards the lower parts of the hair follicle. The human hair follicle, hereby, serves not only as a reservoir, but also as a major entry point for topically applied compounds. Topical delivery of active compounds to specific targets within the skin may help reduce side-effects caused by unspecific reactions, and may help develop new strategies in the prevention and treatment of skin diseases. Various drug carrier and drug delivery systems are currently being investigated. The aim of these investigational efforts is to direct topically applied compounds to the different types of hair follicles and, ideally, to specific compartments and cell populations within the hair follicles. Follicular targeting offers opportunities for new developments, not only in hair therapy and in the treatment of hair follicle associated diseases but also in gene therapy and immunotherapy.

  4. Roxithromycin-loaded lipid nanoparticles for follicular targeting. (United States)

    Wosicka-Frąckowiak, Hanna; Cal, Krzysztof; Stefanowska, Justyna; Główka, Eliza; Nowacka, Magdalena; Struck-Lewicka, Wiktoria; Govedarica, Biljana; Pasikowska, Monika; Dębowska, Renata; Jesionowski, Teofil; Srčič, Stane; Markuszewski, Michał Jan


    Particulate drug carriers e.g. nanoparticles (NPs) have been shown to penetrate and accumulate preferentially in skin hair follicles creating high local concentration of a drug. In order to develop such a follicle targeting system we obtained and characterized solid lipid nanoparticles (SLN) loaded with roxithromycin (ROX). The mean particle size (172±2 nm), polydisperisty index (0.237±0.007), zeta potential (-31.68±3.10 mV) and incorporation efficiency (82.1±3.0%) were measured. The long term stability of ROX-loaded SLN suspensions was proved up to 26 weeks. In vitro drug release study was performed using apparatus 4 dialysis adapters. Skin irritation test conducted using the EpiDerm™ tissue model demonstrated no irritation potential for ROX-loaded SLN. Ex vivo human skin penetration studies, employing rhodamine B hexyl ester perchlorate (RBHE) as a fluorescent dye to label the particles, revealed fluorescence deep in the skin, specifically around the hair follicles up to over 1mm depth. The comparison of fluorescence intensities after application of RBHE solution and RBHE-labelled ROX-loaded SLN was done. Then cyanoacrylate follicular biopsies were obtained in vivo and analyzed for ROX content, proving the possibility of penetration to human pilosebaceous units and delivering ROX by using SLN with the size below 200 nm.

  5. Autologous and allogeneic hematopoietic stem cell transplantation in follicular lymphoma. (United States)

    Bhatt, V R; Armitage, J O


    High-dose chemotherapy and autologous stem cell transplantation (ASCT) improve survival in follicular lymphoma; however, relapse remains the most common cause of death. The lower risk of relapse with allogeneic SCT (alloSCT) is offset by a high transplant-related mortality (TRM). English articles indexed in the MEDLINE database were reviewed to discuss the role of graft purging, rituximab maintenance after ASCT, reduced-intensity conditioning (RIC) alloSCT, T-cell depletion, donor lymphocyte infusion (DLI) and alternate donor sources. Optimal salvage consolidation strategy may utilize ASCT following non-total body irradiation-based conditioning regimen in second remission. Rituximab maintenance after ASCT may improve molecular remission but is not yet shown to improve overall survival. RIC alloSCT permits its use in older and less-fit patients. Studies with T-cell depleted graft failed to reduce TRM despite a decline in graft-versus-host disease; however, these studies did demonstrate a therapeutic role of DLI in post-transplant relapses. In recent years, haploidentical and umbilical cord blood donors have emerged as alternative donor sources, with outcomes comparable to matched unrelated donor SCT. In the future, incorporation of novel therapeutic agents, improved risk-adapted treatment strategies, and advancement of transplant techniques may provide a better chance of survival.

  6. Follicular lymphoma (FL): Immunological tolerance theory in FL. (United States)

    García-Muñoz, Ricardo; Panizo, Carlos


    The ultimate cause of follicular lymphoma (FL) remains unknown. Remarkably, almost nothing is known about immunological tolerance mechanisms that might contribute to FL development. Immunological tolerance mechanisms, like other stimuli, also induce persistent changes of B cell receptors that induce genetic instability and molecular aberrations promoting the development of a neoplasm. Using the same method as Burnet, we provide a new perspective taking advantage of the comparison of a normal linear B cell differentiation process and FL development within the framework of clonal selection theory. We propose that FL is a malignancy of cells that acquire both translocation t(14;18) and self-BCR, inducing them to proliferate and mature, resistant to negative selection. Additional genetic damage induced by non-apoptotic tolerance mechanisms, such as receptor editing, may transform a self-reactive B cell with t(14;18) into an FL. The result of tolerogenic mechanisms and genetic aberrations is the survival of FL B cell clones with similar markers and homogenous gene expression signatures despite the different stages of maturation at which the molecular damage occurs. To antagonize further growth advantage due to self-antigen recognition and chronic activation of tolerance mechanisms in the apoptosis-resistant background of FL B cells, inhibitors of BCR signaling may be promising therapeutic options.

  7. Breast systemic follicular lymphoma in a man: a case report

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    La Mantia Elvira


    Full Text Available Abstract Introduction Breast involvement by non-Hodgkin lymphoma is particularly rare in men. We describe the case of a patient with a rapidly growing, painless gynecomastia-like nodule in the left breast. On ultrasonography, the nodule was suspicious for breast carcinoma. Case presentation A breast biopsy from a 54-year-old Caucasian man showed the morphoimmunophenotypical features of grade 3 follicular lymphoma. Moreover, fluorescence in situ hybridization analysis showed a t(14,18 translocation suggesting breast involvement by a systemic lymphoma rather than a primary breast lymphoma. The histological diagnosis was subsequently confirmed after nodule excision. Mediastinal and abdominal node involvement was then identified on computed tomography and positron emission tomography scans during staging examinations. Our patient was treated with chemotherapy. After three years our patient experienced a right retro-areolar relapse. He then received two further cycles of chemotherapy but developed a myeloid acute leukemia and, as a result of this, he subsequently died. Conclusions The rarity of breast lymphomas, especially in men, and the problems related to the therapeutic choices with these tumors require molecular techniques in association with classical histological diagnosis.

  8. Follicular helper T cell in immunity and autoimmunity

    Directory of Open Access Journals (Sweden)

    D. Mesquita Jr


    Full Text Available The traditional concept that effector T helper (Th responses are mediated by Th1/Th2 cell subtypes has been broadened by the recent demonstration of two new effector T helper cells, the IL-17 producing cells (Th17 and the follicular helper T cells (Tfh. These new subsets have many features in common, such as the ability to produce IL-21 and to express the IL-23 receptor (IL23R, the inducible co-stimulatory molecule ICOS, and the transcription factor c-Maf, all of them essential for expansion and establishment of the final pool of both subsets. Tfh cells differ from Th17 by their ability to home to B cell areas in secondary lymphoid tissue through interactions mediated by the chemokine receptor CXCR5 and its ligand CXCL13. These CXCR5+ CD4+ T cells are considered an effector T cell type specialized in B cell help, with a transcriptional profile distinct from Th1 and Th2 cells. The role of Tfh cells and its primary product, IL-21, on B-cell activation and differentiation is essential for humoral immunity against infectious agents. However, when deregulated, Tfh cells could represent an important mechanism contributing to exacerbated humoral response and autoantibody production in autoimmune diseases. This review highlights the importance of Tfh cells by focusing on their biology and differentiation processes in the context of normal immune response to infectious microorganisms and their role in the pathogenesis of autoimmune diseases.

  9. Emerging concepts in T follicular helper cell responses to malaria. (United States)

    Hansen, Diana S; Obeng-Adjei, Nyamekye; Ly, Ann; Ioannidis, Lisa J; Crompton, Peter D


    Antibody responses to malaria and candidate malaria vaccines are short-lived in children, leaving them susceptible to repeated malaria episodes. Because T follicular helper (TFH) cells provide critical help to B cells to generate long-lived antibody responses, they have become the focus of recent studies of Plasmodium-infected mice and humans. The emerging data converge on common themes, namely, that malaria-induced TH1 cytokines are associated with the activation of (i) T-like memory TFH cells with impaired B cell helper function, and (ii) pre-TFH cells that acquire Th1-like features (T-bet expression, IFN-γ production), which impede their differentiation into fully functional TFH cells, thus resulting in germinal center dysfunction and suboptimal antibody responses. Deeper knowledge of TFH cells in malaria could illuminate strategies to improve vaccines through modulating TFH cell responses. This review summarizes emerging concepts in TFH cell responses to malaria. Copyright © 2016. Published by Elsevier Ltd.

  10. Progesterone Upregulates Gene Expression in Normal Human Thyroid Follicular Cells

    Directory of Open Access Journals (Sweden)

    Ana Paula Santin Bertoni


    Full Text Available Thyroid cancer and thyroid nodules are more prevalent in women than men, so female sex hormones may have an etiological role in these conditions. There are no data about direct effects of progesterone on thyroid cells, so the aim of the present study was to evaluate progesterone effects in the sodium-iodide symporter NIS, thyroglobulin TG, thyroperoxidase TPO, and KI-67 genes expression, in normal thyroid follicular cells, derived from human tissue. NIS, TG, TPO, and KI-67 mRNA expression increased significantly after TSH 20 μUI/mL, respectively: 2.08 times, P<0.0001; 2.39 times, P=0.01; 1.58 times, P=0.0003; and 1.87 times, P<0.0001. In thyroid cells treated with 20 μUI/mL TSH plus 10 nM progesterone, RNA expression of NIS, TG, and KI-67 genes increased, respectively: 1.78 times, P<0.0001; 1.75 times, P=0.037; and 1.95 times, P<0.0001, and TPO mRNA expression also increased, though not significantly (1.77 times, P=0.069. These effects were abolished by mifepristone, an antagonist of progesterone receptor, suggesting that genes involved in thyroid cell function and proliferation are upregulated by progesterone. This work provides evidence that progesterone has a direct effect on thyroid cells, upregulating genes involved in thyroid function and growth.

  11. Follicular thyroid carcinoma mimicking meningioma: A case report

    Directory of Open Access Journals (Sweden)

    Krishnalatha Buandasan


    Full Text Available Follicular thyroid carcinoma (FTC is a well-differentiated tumor which resembles the normal microscopic pattern of the thyroid. Although intracranial metastasis to the brain is frequent in adults, metastasis from FTC is very rare. Dural metastases mimicking meningioma have been documented in the literature now and then. However, cases arising from a FTC are again very rare. We report the case of a middle-aged lady who presented with progressive, painless left eye proptosis. She was noted to have a non-axial proptosis with dystopia, compressive optic neuropathy and exposure keratitis. She also had a painless swelling over the occipital region. She was initially misdiagnosed to have multiple foci of meningioma based on magnetic resonance imaging findings. Subsequent histopathological examination revealed presence of FTC. She was euthyroid but was found to have multiple small thyroid nodules by ultrasonography. Hence, the definite diagnosis of all dural masses must be histological wherever possible and thyroid carcinoma should be considered as a potential primary tumour in such presentations.

  12. Reconnaissance Level Studies on a Storm Surge Barrier for Flood Risk Reduction in the Houston-Galveston Bay

    NARCIS (Netherlands)

    Jonkman, S.N.; Mooyaart, L.F.; Van Ledden, M.; Stoeten, K.J.; De Vries, P.A.L.; Lendering, K.T.; Van der Toorn, A.; Willems, A.


    The Houston - Galveston area is at significant risk from hurricane induced storm surges. This paper summarizes ongoing studies on flood risk reduction for the region. Firstly, based on a simplified probabilistic hurricane surge model , the return periods of surges within the bay have been estimated.

  13. A preliminary study on the intensity of cold wave storm surges of Laizhou Bay (United States)

    Li, Xue; Dong, Sheng


    Dike failure and marine losses are quite prominent in Laizhou Bay during the period of cold wave storm surges because of its open coastline to the north and flat topography. In order to evaluate the intensity of cold wave storm surge, the hindcast of marine elements induced by cold waves in Laizhou Bay from 1985 to 2004 is conducted using a cold wave storm surge-wave coupled model and the joint return period of extreme water level, concomitant wave height, and concomitant wind speed are calculated. A new criterion of cold wave storm surge intensity based on such studies is developed. Considering the frequency of cold wave, this paper introduces a Poisson trivariate compound reconstruction model to calculate the joint return period, which is closer to the reality. By using the newly defined cold wave storm surge intensity, the `cold wave grade' in meteorology can better describe the severity of cold wave storm surges and the warning level is well corresponding to different intensities of cold wave storm surges. Therefore, it provides a proper guidance to marine hydrological analysis, disaster prevention and marine structure design in Laizhou Bay.

  14. Microstructural evaluation of a varistor block utilized in high voltage surge arresters; Avaliacao microestrutural de um bloco varistor utilizado em para-raios de alta tensao

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, J.M. de; Dias, R.; Furtado, J.G. de M., E-mail: [Centro de Pesquisas de Energia Eletrica (CEPEL), Rio de Janeiro, RJ (Brazil); Assuncao, F.C.R. [Pontificia Univ. Catolica do Rio de Janeiro (PUC-Rio), RJ (Brazil)


    Varistor is a semiconductor ceramic device characterized to have a high non-linear electrical resistance, it is used as active element of surge arresters with purpose of protecting of electro-electronics systems. Its properties are directly dependents of chemical composition and microstructural characteristics, such as grain size, porosity, twins and phases distribution. This work has the objective to characterize microstructurally a commercial varistor block of ZnO used in high voltage surge arrest and from this characterization to infer aspects about of its electrical macroscopic performance. DRX and SEM-EDS were used for microstructural analysis. The microstructural evaluation allows pointing the critical points of microstructure and, suggest relevant aspects to the improvement of commercial varistor microstructure, optimizing the electrothermal behavior of the device. (author)

  15. Immunohistochemical expression of MMP-14 and MMP-2, and MMP-2 activity during human ovarian follicular development



    BACKGROUND: The aim of this study was to investigate the presence of MMP-14 and MMP-2 during human ovarian follicular development using immunohistochemistry, and the activity of MMP-2 in follicular fluid using zymography. METHODS: Ovarian tissue collected from the archives of the Department of Pathology was examined and medical records and histopathology were reviewed. Follicular fluids were collected at the IVF-department and analyzed using zymography. RESULTS: MMP-14 and MMP-2 were increasi...

  16. Slab entrainment and surge dynamics of the 2015 Valleé de la Sionne avalanches (United States)

    Köhler, Anselm; McElwaine, Jim; Sovilla, Betty


    On 3 February 2015 five avalanches were artificially released at the Valleé de la Sionne test site in the west of Switzerland. The dense parts of the avalanches were tracked by the GEODAR Mark 2 radar system at 111 Hz framerate with 0.75 m down slope resolution. The data show that these avalanche contain several internal surges and that the avalanche front is repeatedly overtaken by some of these surges. We show that these surges exist on different scale. While the major surges originates from secondary triggered slab releases and occur all over the avalanche. The minor surges are only found in the energetic part of a well developed powder snow avalanche. The mass of the major surges can be as huge as the initial released mass, this has a dramatic effect on the mass distribution inside the avalanche and effects the front velocity and run out. Furthermore, the secondary released snow slabs are an important entrainment mechanism and up to 50 percent of the mass entered the avalanche via slab entrainment. We analyse the dynamics of the leading edge and the minor surges in more detail using a simple one dimensional model with frictional resistance and quadratic velocity dependent drag. These models fit the data well for the start and middle of avalanche but cannot capture the slowing and overtaking of the minor surge. We find much higher friction coefficients to describe the surging. We propose that this data can only be explained by changes in the snow surface. These effects are not included in current models yet, but the data presented here will enable the development and verification of such models.

  17. The influence of coastal wetlands on hurricane surge in Corpus Christi, TX (United States)

    Ferreira, C.; Irish, J. L.; Olivera, F.


    The State of Texas has historically faced hurricane-related damage episodes, with Ike being the most recent example. It is expected that, in the future, hurricanes will intensify due to climate change causing greater surges, while the attenuating effect of wetlands on storm surges will also be modified due to sea level rise changes in wetland vegetation type and spatial location. Numerical analysis of storm surges is an important instrument to predict and simulate flooding extent and magnitude in coastal areas. Most operational surge models account for the influence of wetlands and other vegetation by momentum loss due to friction at the bottom and by reduction of imposed wind stress. A coupled hydrodynamic model (ADCIRC) and wave model (SWAN) was employed, and wetlands were characterized using Manning’s n, surface canopy, and surface roughness. The wetlands parameters were developed from: 1) the National Land Cover Dataset (NLCD) 1992 and 2001; 2) the National Wetlands Inventory (NWI) 2001. The calibrated coupled model for two historical hurricanes, Bret and Beulah, was used to simulate the storm surge for each scenario. Preliminary results for the sensitivity analyses, for hurricane Bret, comparing the scenarios with parameters developed from NLCD and NWI datasets with four hypothetical scenarios considering very high and low Manning’s n and wind stress (surface canopy) values showed that, for areas inside Nueces Bay, the storm surge high could vary up to four times depending on the parameter selection, for areas inside Corpus Christi Bay, the storm surge high varied around three times and behind the barrier island the storm surge high variation was less than three times. This study is a first step for an evaluation of the impact that sea level rise, climate changed wetlands, wetlands restoration, land use change, and wetlands degradation have on hurricane related surge elevation and extent in the city of Corpus Christi.

  18. A global record of large storm surges and loss of life (United States)

    Bouwer, Laurens; Jonkman, Sebastiaan


    Storm surges can cause very high numbers of loss of life (fatalities) in single events, and these events are expected to increase due to sea-level rise and increasing population in coastal zones. However, compared to fatalities from fresh water flooding, for storm surges these fatality numbers are not consistently recorded, and often neglected in scientific assessments. In order to assess the impacts of major coastal storm surge events at the global level, we have developed a record of these events and associated loss of life. Information was compiled from the EM-DAT database for the period 1900-2013, using the two key categories of "Tropical cyclone" and "Storm surge/coastal flood", complemented with other databases and sources of information, and records of observed surge levels. We find that globally, each year on average about 8,500 people are killed and 1.3 million people are affected by storm surges. The occurrence of very substantial loss of life (>10,000 persons) from single events has decreased over time, which is in contrast with the slight increasing trends in fatalities observed for fresh water flooding. Also, there is a consistent and strong decrease in event mortality, which is the fraction of the people exposed to surges that lose their life, for all global regions, except South-East Asia. Thus, reduction in vulnerability to loss of life over time plays a significant role in storm surge impacts. We also find that for the same coastal surge water level, mortality appears to have decreased over time, showing the robustness of this finding. This quantified decline can be attributed to risk reduction efforts over the last decades, including improved forecasting, early warning and evacuation, but also improved coastal protection. These results have important implications for assessment studies on current and projected future coastal flood risk, as historical mortality fractions may not be valid to assess impacts from future events.

  19. Developing an early warning system for storm surge inundation in the Philippines

    Directory of Open Access Journals (Sweden)

    J. Tablazon


    Full Text Available A storm surge is the sudden rise of sea water generated by an approaching storm, over and above the astronomical tides. This event imposes a major threat in the Philippine coastal areas, as manifested by Typhoon Haiyan on 8 November 2013 where more than 6000 people lost their lives. It has become evident that the need to develop an early warning system for storm surges is of utmost importance. To provide forecasts of the possible storm surge heights of an approaching typhoon, the Nationwide Operational Assessment of Hazards under the Department of Science and Technology (DOST-Project NOAH simulated historical tropical cyclones that entered the Philippine Area of Responsibility. Bathymetric data, storm track, central atmospheric pressure, and maximum wind speed were used as parameters for the Japan Meteorological Agency Storm Surge Model. The researchers calculated the frequency distribution of maximum storm surge heights of all typhoons under a specific Public Storm Warning Signal (PSWS that passed through a particular coastal area. This determines the storm surge height corresponding to a given probability of occurrence. The storm surge heights from the model were added to the maximum astronomical tide data from WXTide software. The team then created maps of probable area inundation and flood levels of storm surges along coastal areas for a specific PSWS using the results of the frequency distribution. These maps were developed from the time series data of the storm tide at 10 min intervals of all observation points in the Philippines. This information will be beneficial in developing early warnings systems, static maps, disaster mitigation and preparedness plans, vulnerability assessments, risk-sensitive land use plans, shoreline defense efforts, and coastal protection measures. Moreover, these will support the local government units' mandate to raise public awareness, disseminate information about storm surge hazards, and implement

  20. Impact of Low-Level Southerly Surges on Mixed Rossby Gravity Waves over the Central Pacific. (United States)

    Fukutomi, Y.


    This study examines dynamical impacts of lower-tropospheric southerly wind surges originating in midlatitudes of the Southern Hemisphere (SH) on the development of mixed Rossby gravity (MRG) waves over the central Pacific during June-August 1979-2012, through the statistical analysis of the JRA-55 products and NOAA outgoing long wave radiation data. The central Pacific MRG waves are identified by an extended EOF (EEOF) analysis on 2-8-day filtered daily 850-hPa meridional wind anomalies during June-August 1979-2012. Composite analysis based on the leading EEOF time coefficients is able to capture the development of the MRG waves associated with a southerly surge originating in the SH extratropics. As a weak clockwise gyre as a part of an off-equatorial easterly wavetrain moves eastward and southeastward from the off-equatorial eastern Pacific into the equatorial central Pacific, the southerly surge penetrates into the equatorial tropics at around 150W. Then, the clockwise gyre develops into a MRG-type gyre over the central Pacific. A transition from an easterly wave-type gyre into a MRG-type gyre occurs associated with the southerly surge. The southerly surge forms a cross-equatorial flow on the western flank of the MRG-type gyre. The gyre is amplified when the southerly surge reaches the equatorial tropics. At the same time, convection coupled with the MRG-type gyre is enhanced. The southerly surges are originated in the midlatitude South Pacific, and they are induced by synoptic-scale baroclinic disturbances propagating along the SH midlatitude westerly jet. An eddy vorticity budget analysis indicates that the southerly surge plays an important role in spinning up the MRG-type gyre through transient advection of absolute vorticiy. A case study of a MRG-wave event in mid-July 2006 also illustrates development of a MRG wave associated with the southerly surge and an easterly wave-to-MRG wave transition.

  1. Identification of storm surge events over the German Bight from atmospheric reanalysis and climate model data (United States)

    Befort, D. J.; Fischer, M.; Leckebusch, G. C.; Ulbrich, U.; Ganske, A.; Rosenhagen, G.; Heinrich, H.


    A new procedure for the identification of storm surge situations for the German Bight is developed and applied to reanalysis and global climate model data. This method is based on the empirical approach for estimating storm surge heights using information about wind speed and wind direction. Here, we hypothesize that storm surge events are caused by high wind speeds from north-westerly direction in combination with a large-scale wind storm event affecting the North Sea region. The method is calibrated for ERA-40 data, using the data from the storm surge atlas for Cuxhaven. It is shown that using information of both wind speed and direction as well as large-scale wind storm events improves the identification of storm surge events. To estimate possible future changes of potential storm surge events, we apply the new identification approach to an ensemble of three transient climate change simulations performed with the ECHAM5/MPIOM model under A1B greenhouse gas scenario forcing. We find an increase in the total number of potential storm surge events of about 12 % [(2001-2100)-(1901-2000)], mainly based on changes of moderate events. Yearly numbers of storm surge relevant events show high interannual and decadal variability and only one of three simulations shows a statistical significant increase in the yearly number of potential storm surge events between 1900 and 2100. However, no changes in the maximum intensity and duration of all potential events is determined. Extreme value statistic analysis confirms no frequency change of the most severe events.

  2. Identification of storm surge events over the German Bight from atmospheric reanalysis and climate model data

    Directory of Open Access Journals (Sweden)

    D. J. Befort


    Full Text Available A new procedure for the identification of storm surge situations for the German Bight is developed and applied to reanalysis and global climate model data. This method is based on the empirical approach for estimating storm surge heights using information about wind speed and wind direction. Here, we hypothesize that storm surge events are caused by high wind speeds from north-westerly direction in combination with a large-scale wind storm event affecting the North Sea region. The method is calibrated for ERA-40 data, using the data from the storm surge atlas for Cuxhaven. It is shown that using information of both wind speed and direction as well as large-scale wind storm events improves the identification of storm surge events. To estimate possible future changes of potential storm surge events, we apply the new identification approach to an ensemble of three transient climate change simulations performed with the ECHAM5/MPIOM model under A1B greenhouse gas scenario forcing. We find an increase in the total number of potential storm surge events of about 12 % [(2001–2100–(1901–2000], mainly based on changes of moderate events. Yearly numbers of storm surge relevant events show high interannual and decadal variability and only one of three simulations shows a statistical significant increase in the yearly number of potential storm surge events between 1900 and 2100. However, no changes in the maximum intensity and duration of all potential events is determined. Extreme value statistic analysis confirms no frequency change of the most severe events.

  3. Surge Capacity of Hospitals in Emergencies and Disasters With a Preparedness Approach: A Systematic Review. (United States)

    Sheikhbardsiri, Hojjat; Raeisi, Ahmad Reza; Nekoei-Moghadam, Mahmood; Rezaei, Fatemeh


    Surge capacity is one of the most important components of hospital preparedness for responding to emergencies and disasters. The ability to provide health and medical care during a sudden increase in the number of patients or victims of disasters is a main concern of hospitals. We aimed to perform a systematic review of hospital surge capacity in emergencies and disasters with a preparedness approach. A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The key words "surge," "surge capacity," "preparedness," "hospital emergency department," "hospital," "surge capability," "emergency," "hazard," "disaster," "catastrophe," "crisis," and "tragedy" were used in combination with the Boolean operators OR and AND. The Google Scholar, ISI Web of Science, Science Direct, PubMed, Scopus, Ovid, Pro Quest, and Wiley databases were searched. A total of 1008 articles were extracted and 17 articles were selected for final review of surge capacity based on the objective of the study. Seventeen studies (1 randomized controlled trial, 2 qualitative studies, and 14 cross-sectional studies) investigated the surge capacity of hospitals in emergencies and disasters to evaluate the best evidence to date. The results of selected articles indicated that there are various ways to increase the capacity of hospitals in 4 domains: staff, stuff, structure, and system. Surge capacity is a basic element of disaster preparedness programs. Results of the current study could help health field managers in hospitals to prepare for capacity-building based on surge capacity components to improve and promote hospital preparedness programs. (Disaster Med Public Health Preparedness. 2017;page 1 of 9).

  4. Thermal structure of Svalbard glaciers and implications for thermal switch models of glacier surging (United States)

    Sevestre, Heïdi; Benn, Douglas I.; Hulton, Nicholas R. J.; Bælum, Karoline


    Switches between cold- and warm-based conditions have long been invoked to explain surges of High Arctic glaciers. Here we compile existing and new data on the thermal regime of six glaciers in Svalbard to test the applicability of thermal switch models. Two of the large glaciers of our sample are water terminating while one is land terminating. All three have a well-known surge history. They have a thick basal layer of temperate ice, superimposed by cold ice. A cold terminus forms during quiescence but is mechanically removed by calving on tidewater glaciers. The other three glaciers are relatively small and are either entirely cold or have a diminishing warm core. All three bear evidence of former warm-based thermal regimes and, in two cases, surge-like behavior during the Little Ice Age. In Svalbard, therefore, three types of glaciers have switched from slow to fast flow: (1) small glaciers that underwent thermal cycles during and following the Little Ice Age (switches between cold- and warm-based conditions), (2) large terrestrial glaciers which remain warm based throughout the entire surge cycle but develop cold termini during quiescence, and (3) large tidewater glaciers that remain warm based throughout the surge cycle. Our results demonstrate that thermal switching cannot explain the surges of large glaciers in Svalbard. We apply the concept of enthalpy cycling to the spectrum of surge and surge-like behavior displayed by these glaciers and demonstrate that all Svalbard surge-type glaciers can be understood within a single conceptual framework.

  5. Association between the rate of the morning surge in blood pressure and cardiovascular events and stroke

    Institute of Scientific and Technical Information of China (English)

    LUO Yu; WANG Yan-li; WU Ying-biao; XU Yao; Geoffrey A.Head; Macgrathy Barry; LIANG Yu-lu


    Background The exaggerated surge in morning blood pressure (BP) that many patients experience upon awakening may be closely related to target organ damage and may be a predictor of cardiovascular complications.However,no previous studies have evaluated the rate of this surge independently of the evening period.It remains unclear whether the rate of increase experienced during the surge is a significant or independent determinant of cardiovascular events.Methods We randomly selected 340 ambulatory BP monitoring (ABPM) patients.All subjects without type 2 diabetes mellitus were divided into two groups:hypertensive group (n=170) and normotensive group (n=170).We analyzed ambulatory blood pressure recordings using a double logistic curve-fitting procedure to determine whether the magnitude of the surge in BP and heart rate (HR) in the morning is related to the level of BP in hypertensive individuals.We evaluated the association between the rate of the morning surge in systolic BP (SBP) and the incidence of myocardial infarction and stroke in normotensive and hypertensive subjects.Results Comparisons between hypertensive and normotensive subjects showed that the rates of the morning surges in SBP,mean BP (MBP),and diastolic BP (DBP) were greater in the hypertensive group (P <0.05) than in the normotensive group.The rate of morning surge in BP was found to be correlated with the daytime SBP (r=0.236,P <0.01),the difference between the day and night plateau (r=0.249,P <0.01),and the night SBP (r=-0.160,P <0.05),respectively.After controlling for age,sex,and mean systolic pressure within 24 hours (24 h SBP),the rate of morning surge in SBP was closely correlated with daytime SBP (r=0.463,P <0.001),night SBP (r=-0.173,P <0.05),and the difference between the day and night plateau (r=0.267,P <0.001).Logistic regression analysis revealed that the rate of morning surge in SBP was an independent determinant of myocardial infarction (OR=1.266,95% CI=1.153-1.389,P

  6. RET receptor expression in thyroid follicular epithelial cell-derived tumors. (United States)

    Bunone, G; Uggeri, M; Mondellini, P; Pierotti, M A; Bongarzone, I


    The RET proto-oncogene encodes a receptor tyrosine kinase for transforming growth factor-beta-related neurotrophic factors, which include GDNF and neurturin. The expression of RET proto-oncogene was detected in several tissues, such as spleen, thymus, lymph nodes, salivary gland, and spinal cord, and in several neural crest-derived cell lines. RET expression in the thyroid gland was reported to be restricted to neural crest-derived C cells. The presence of RET mRNA or protein has not yet been reported in thyroid follicular cells. We previously demonstrated the expression of oncogenic rearranged versions of RET in papillary thyroid carcinomas: tumors derived from thyroid follicular cells. To assess the expression of the normal RET proto-oncogene in follicular cells, we analyzed its expression in a panel of neoplasias originating from thyroid follicular epithelial cells: papillary carcinomas and both follicular adenomas and carcinomas. We also demonstrated the presence of RET normal transcripts in two follicular thyroid carcinoma lymph node metastases. Moreover, we found the presence of the RET/ELE1 transcript, the reciprocal complementary form of the oncogenic fusion transcript ELE1/RET, in a papillary thyroid carcinoma specimen expressing the RET/PTC3 oncogene, thus demonstrating that the RET promoter is active in those cells after rearrangement. Finally, we show that in a papillary carcinoma-derived cell line expressing the proto-RET receptor and the related GFRalpha2 co-receptor, GDNF treatment induced RET tyrosine phosphorylation and subsequent signal transduction pathway, indicating that RET could be active in thyroid follicular cells.

  7. Atypia of undetermined significance and follicular lesions of undetermined significance: sonographic assessment for prediction of the final diagnosis

    National Research Council Canada - National Science Library

    Kamaya, Aya; Lewis, Gloria Huang; Liu, Yi; Akatsu, Haruko; Kong, Christina; Desser, Terry S


    To determine whether radiologic assessment of thyroid nodules can potentially help guide clinical management after a cytologic diagnosis of atypia of undetermined significance or a follicular lesion...

  8. Smart Ultrasound Remote Guidance Experiment (SURGE) Preliminary Findings (United States)

    Hurst, Victor; Dulchavsky, Scott; Garcia, Kathleen; Sargsyan, Ashot; Ebert, Doug


    To date, diagnostic quality ultrasound images were obtained aboard the International Space Station (ISS) using the ultrasound of the Human Research Facility (HRF) rack in the Laboratory module. Through the Advanced Diagnostic Ultrasound in Microgravity (ADUM) and the Braslet-M Occlusion Cuffs (BRASLET SDTO) studies, non-expert ultrasound operators aboard the ISS have performed cardiac, thoracic, abdominal, vascular, ocular, and musculoskeletal ultrasound assessments using remote guidance from ground-based ultrasound experts. With exploration class missions to the lunar and Martian surfaces on the horizon, crew medical officers will necessarily need to operate with greater autonomy given communication delays (round trip times of up to 5 seconds for the Moon and 90 minutes for Mars) and longer periods of communication blackouts (due to orbital constraints of communication assets). The SURGE project explored the feasibility and training requirements of having non-expert ultrasound operators perform autonomous ultrasound assessments in a simulated exploration mission outpost. The project aimed to identify experience, training, and human factors requirements for crew medical officers to perform autonomous ultrasonography. All of these aims pertained to the following risks from the NASA Bioastronautics Road Map: 1) Risk 18: Major Illness and Trauna; 2) Risk 20) Ambulatory Care; 3) Risk 22: Medical Informatics, Technologies, and Support Systems; and 4) Risk 23: Medical Skill Training and Maintenance.

  9. Nivmar: a storm surge forecasting system for Spanish waters

    Directory of Open Access Journals (Sweden)

    Enrique Álvarez Fanjul


    Full Text Available In this paper, a storm surge prediction system for the Spanish Waters is presented. The system, named Nivmar, is based on the ocean circulation Hamsom model and on the harmonical prediction of tides computed from data measured by the tide gauge network Redmar, managed by Puertos del Estado. Nivmar is executed twice a day, running Hamsom forced by meteorological fields derived from the INM (Instituto Nacional de Meteorología operational application of Hirlam atmospheric model. Data from Redmar tide gauges is used to to forecast the tidal elevations, to validate the system and to perform data assimilation, correcting systematic errors in the mean sea level due to physicals processes that are not included in the ocean model (i. e. steric height. The forecast horizon is 48 hours. In order to validate the system with measured data from Redmar a very stormy 5 months period was selected. Results from this test (November 95 to March 96 are presented. Data from this experiment shown that Nivmar is able to correctly predict sea level in the region. A simple data assimilation scheme for sea level is described and results from its application are studied. Finally, special focus is made in future plans and potential developments and applications of the system.

  10. The effects of varying the interval from follicular wave emergence to progestin withdrawal on follicular dynamics and the synchrony of estrus in beef cattle. (United States)

    Utt, M D; Jousan, F D; Beal, W E


    The objective of this experiment was to examine the effects of varying the interval from follicular wave emergence to progestin (controlled internal drug-releasing insert, CIDR) withdrawal on follicular dynamics and the synchrony of estrus. A secondary objective was to assess the effects of causing the dominant follicle (DF) to develop in the presence or absence of a corpus luteum (CL) on follicular dynamics and the synchrony of estrus and ovulation. The experiment was designed as a 2 x 2 x 2 factorial arrangement of treatments with injection of GnRH or estradiol-17 beta and progesterone (E2 + P4) at treatment initiation, duration of CIDR treatment, and injection of PG (prostaglandin F2 alpha) or saline at the time of CIDR insertion as main effects. Estrous cycles (n = 49) in Angus cows were synchronized, and treatments commenced on d 6 to 8 of the estrous cycle. Cows were randomly assigned to receive a CIDR containing 1.9 g of P4 for 7 or 9 d. Approximately half the cows from each CIDR group received either GnRH (100 micrograms) or E2 + P4 (1 mg of E2 + 100 mg of P4) at CIDR insertion. Cows in GnRH or E2 + P4 groups were divided into those that received PG (37.5 mg) or saline at CIDR insertion. All cows received PG (25 mg) 1 d before CIDR removal. Daily ovarian events were monitored via ultrasound. The intervals from GnRH or E2 + P4 treatment to follicular wave emergence were 1.4 and 3.3 d, respectively (P 0.05). Altering the interval from follicular wave emergence to progestin removal or creating different luteal environments in which the DF developed caused differences in the size of the DF at CIDR removal and the timing of the onset of estrus, but it did not affect the synchrony of estrus or ovulation.

  11. Anti-ICOS Monoclonal Antibody MEDI-570 in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma Follicular Variant or Angioimmunoblastic T-cell Lymphoma (United States)


    Follicular Variant Peripheral T-Cell Lymphoma; Grade 1 Follicular Lymphoma; Grade 2 Follicular Lymphoma; Grade 3a Follicular Lymphoma; Recurrent Angioimmunoblastic T-cell Lymphoma; Recurrent Follicular Lymphoma; Recurrent Mature T- and NK-Cell Non-Hodgkin Lymphoma; Recurrent Mycosis Fungoides; Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma; Refractory Angioimmunoblastic T-cell Lymphoma; Refractory Follicular Lymphoma; Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Stage IB Mycosis Fungoides; Stage II Mycosis Fungoides; Stage III Cutaneous T-Cell Non-Hodgkin Lymphoma; Stage III Mycosis Fungoides; Stage IV Cutaneous T-Cell Non-Hodgkin Lymphoma; Stage IV Mycosis Fungoides

  12. Experimental Hydro-Mechanical Characterization of Full Load Pressure Surge in Francis Turbines (United States)

    Müller, A.; Favrel, A.; Landry, C.; Yamamoto, K.; Avellan, F.


    Full load pressure surge limits the operating range of hydro-electric generating units by causing significant power output swings and by compromising the safety of the plant. It appears during the off-design operation of hydraulic machines, which is increasingly required to regulate the broad integration of volatile renewable energy sources into the existing power network. The underlying causes and governing physical mechanisms of this instability were investigated in the frame of a large European research project and this paper documents the main findings from two experimental campaigns on a reduced scale model of a Francis turbine. The multi-phase flow in the draft tube is characterized by Particle Image Velocimetry, Laser Doppler Velocimetry and high-speed visualizations, along with synchronized measurements of the relevant hydro-mechanical quantities. The final result is a comprehensive overview of how the unsteady draft tube flow and the mechanical torque on the runner shaft behave during one mean period of the pressure oscillation, thus defining the unstable fluid-structure interaction responsible for the power swings. A discussion of the root cause is initiated, based on the state of the art. Finally, the latest results will enable a validation of recent RANS flow simulations used for determining the key parameters of hydro-acoustic stability models.

  13. Variation of Tower Footing Resistance on the Lightning Surge Propagation through Overhead Power Distribution Lines

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    MARIUT, E. L.


    Full Text Available This paper deals with the analysis of the effects of electromagnetic transients generated by lightning on power distribution lines, considering the influence of tower footing resistance variation. Both types of lightning stroke, direct and induced, are considered. The model of a 20 kV three-phase overhead power distribution line is performed considering a simple line circuit with triangle canopy and 50/8 mm2 Ol-Al conductors. The model of the power distribution line is done considering a Multistory tower model. New concepts regarding lightning assessment through Electromagnetic Transients program and Finite Element Method are implemented. The simulations are performed based on a time domain analysis, considering the lightning stroke as an electromagnetic perturbation within frequency range of 10-100 kHz. A contribution to value creation is the design of the Multistory tower model, used for electromagnetic transients analysis for medium voltage power distribution lines. Excepting previous research, current study was done by considering the variation of tower footing resistance of the tower, between 4-35 ohms. The novelty of the study is the analysis of the dependency determined by the variation of tower footing resistance on the lightning surge propagation through power distribution networks and subsequent consumers.

  14. Thyroid follicular carcinoma presenting as metastatic skin nodules

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    Asad Jehangir


    Full Text Available Background: Follicular thyroid cancer (FTC metastasizes most commonly to the lungs and non-cranial bones. Skull and skin are uncommon sites and usually manifest well after the diagnosis of primary malignancy. Metastasis to skull and skin as the presenting feature of FTC is infrequently reported in the literature. Case presentation: A 65-year-old Caucasian woman with a history of thyroid nodule presented with the complaint of rapidly growing skull nodules which had been present for 3 years but were stable previously. She denied any fevers, chills, history of trauma, or weight loss. She denied any history of smoking or head and neck irradiation. On physical examination, she had two non-tender gray cystic lesions – one on her left temporal region and the other on the right parietal region. Biopsy was consistent with metastatic FTC. Magnetic resonance imaging of the brain demonstrated 7.1×3.8 cm and 3.7×4.5 cm fairly homogeneous, enhancing, relatively well-defined masses centered in the posterior and left anterior lateral calvarium with intracranial and extracranial extensions but without any vasogenic edema or mass effect on the brain. Thyroid ultrasound showed numerous nodules in both lobes. The patient underwent a total thyroidectomy. Histopathological studies of the thyroid gland revealed a well-differentiated FTC in the left lobe. Then she underwent resection of the tumor in multiple stages. She did not have any recurrence of the FTC or metastases during the follow-up period and will be receiving radioactive iodine treatment. Conclusion: Bone and lung are the common sites of metastasis from FTC, but involvement of skull or skin is unusual, particularly as the presenting feature. Metastases from FTC should be in the differential of patients with new osteolytic hypervascular skull lesions or cutaneous lesions in head and neck area.

  15. Lightning arrester models enabling highly accurate lightning surge analysis; Koseidona kaminari surge kaiseki wo kano ni suru hiraiki model

    Energy Technology Data Exchange (ETDEWEB)

    Ueda, T. [Chubu Electric Power Co. Inc., Nagoya (Japan); Funabashi, T.; Hagiwara, T.; Watanabe, H. [Meidensha Corp., Tokyo (Japan)


    Introduced herein are a dynamic behavior model for lightning arresters designed for power stations and substations and a flashover model for a lightning arresting device designed for transmission, both developed by the author et al. The author et al base their zinc oxide type lightning arrester model on the conventional static V-I characteristics, and supplement them with difference in voltage between static and dynamic characteristics. The model is easily simulated using EMTP (Electromagnetic Transients Program) etc. There is good agreement between the results of calculation performed using this model and actually measured values. Lightning arresting devices for transmission have come into practical use, and their effectiveness is introduced on various occasions. For the proper application of such devices, an analysis model capable of faithfully describing the flashover characteristics of arcing horns installed in great numbers along transmission lines, and of lightning arresting devices for transmission, are required. The author et al have newly developed a flashover model for the devices and uses the model for the analysis of lightning surges. It is found that the actually measured values of discharge characteristics of lightning arresting devices for transmission agree well with the values calculated by use of the model. (NEDO)

  16. Developmental programming: Impact of prenatal testosterone treatment and postnatal obesity on ovarian follicular dynamics. (United States)

    Padmanabhan, V; Smith, P; Veiga-Lopez, A


    Prenatal testosterone (T) excess leads to reproductive dysfunctions in sheep with obesity exaggerating such defects. Developmental studies found ovarian reserve is similar in control and prenatal T sheep at fetal day 140, with prenatal T females showing increased follicular recruitment and persistence at 10 months of age (postpubertal). This study tested if prenatal T sheep show accelerated depletion prepubertally and if depletion of ovarian reserve would explain loss of cyclicity in prenatal T females and its amplification by postnatal obesity. Stereological examinations were performed at 5 (prepubertal, control and prenatal T) and 21 months (control, prenatal T and prenatal T obese, following estrus synchronization) of age. Obesity was induced by overfeeding from weaning. At 5 months, prenatal T females had 46% less primordial follicles than controls (P obesity did not exaggerate the impact of prenatal T on follicular recruitment indicating that compounding effects of obesity on loss of cyclicity females is not due to depletion of ovarian reserve. Assessment of follicular dynamics across several time points during the reproductive life span (this and earlier study combined) provides evidence supportive of a shift in follicular dynamics in prenatal T females from one of accelerated follicular depletion initiated prior to puberty to stockpiling of growing follicles after puberty, a time point critical in the development of the polycystic ovary syndrome phenotype.

  17. Phenotypes of the ovarian follicular basal lamina predict developmental competence of oocytes (United States)

    Irving-Rodgers, Helen F.; Morris, Stephanie; Collett, Rachael A.; Peura, Teija T.; Davy, Margaret; Thompson, Jeremy G.; Mason, Helen D.; Rodgers, Raymond J.


    BACKGROUND The ovarian follicular basal lamina underlies the epithelial membrana granulosa and maintains the avascular intra-follicular compartment. Additional layers of basal lamina occur in a number of pathologies, including pili annulati and diabetes. We previously found additional layers of follicular basal lamina in a significant percentage of healthy bovine follicles. We wished to determine if this phenomenon existed in humans, and if it was related to oocyte function in the bovine. METHODS AND RESULTS We examined follicles from human ovaries (n = 18) by electron microscopy and found that many follicles had additional layers of basal lamina. Oocytes (n = 222) from bovine follicles with normal or unusual basal laminas were isolated and their ability to undergo in vitro maturation, fertilization and culture to blastocyst was compared. Healthy bovine follicles with a single layer of basal lamina had oocytes with significantly (P < 0.01) greater developmental competence than healthy follicles with additional layers of follicular basal lamina (65% versus 28%). CONCLUSIONS These findings provide direct evidence that the phenotype of the follicular basal lamina is related to oocyte competence. PMID:19095662

  18. Immunohistochemical Detection of p75 Neurotrophin Receptor (p75-NTR) in Follicular and Plexiform Ameloblastoma (United States)

    Madhavan, Nirmal Ramadas; Mohan, Sunil Paramel; Kumar, Srichinthu Kenniyan


    Introduction Ameloblastoma holds a unique position among benign tumours by its locally destructive and invasive nature. Recently improvised molecular techniques helped researchers to unravel the myth behind such biologic behaviour. Though interesting findings have been delivered, the rhythmic correlation regarding the exact mechanism still remains lacking. Neurotrophins and their receptor mediated pathways play a crucial role in survival, death and differentiation of many neuroectoderm derived cells. With this background, the study has been aimed to investigate the expression of p75-NTR (Neurotrophin Receptor) in follicular and plexiform ameloblastoma. Aim To analyze the immunohistochemical expression pattern of p75-NTR in ameloblastoma and to compare the immunohistochemical expression pattern of p75-NTR among the histological types of ameloblastoma, follicular and plexiform patterns. Materials and Methods Total 22 ameloblastomas (12 follicular, 10 plexiform) were immuno-stained with anti-human p75-NTR mouse IgG monoclonal antibody and the pattern of staining is statistically analyzed. Results Only 11 (10 follicular, 1 plexiform) out of 22 ameloblastomas showed immuno-reactivity to p75-NTR. In ameloblastoma, only the peripheral pre-ameloblast like tall columnar cells showed reactivity whereas the stellate reticulum-like cells were immuno-negative. The staining pattern was membranous in the immuno-reactive cells. The results were studied with the downstream pathways from the literature and a possible mechanism has been proposed. Conclusion The expression pattern of p75-NTR was found to be more in follicular ameloblastoma than plexiform. PMID:27656566

  19. Some biochemical constituents in follicular fluid of indigenous cows of Assam

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    S. S. Deka


    Full Text Available Aim: Estimation of some biochemical constituents in follicular fluid of non-descript cows of Assam. Materials and Methods: Twenty five pairs of ovaries were collected from local slaughter house and the follicular fluid was aspirated from small (2-4 mm, medium (4-6 mm and large (6-9 mm follicles. Aspirated fluid samples were centrifuged at 4000 rpm for 20 min in a refrigerated centrifuge to remove granulosa cells and other cell debris. Supernatant was used for estimation of glucose, total protein, cholesterol, acid phosphatase and alkaline phosphatase. Data generated in the study were analyzed statiscally by SPSS (version 16.0. SPSS South Asia Pvt. Limited, Kacharakanahalli, Bangalore, 560043. Results: A non significant difference was recorded in case of total protein and cholesterol of follicular fluid of small, medium and large sized follicles of cow. However, the glucose level significantly (p<0.01 increased with the increase of follicular size where as the activity of acid phosphatase and alkaline phosphatase significantly (p<0.01 decreased with increase of size. Conclusion: Certain biochemical constituents and enzyme activities of follicular fluid changes with the growth of follicles in non-descript cows of Assam. The glucose concentration increased with the growth of the follicles while acid phosphatase and alkaline phosphatase levels had an inverse relation with the size of the ovarian follicles.

  20. Simultaneous Occurrence of Different Follicular Neoplasms within the Same Thyroid Gland

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    Şefika Burçak Polat


    Full Text Available Purpose: Neoplasms of the thyroid gland are classified according to the cells they originate from and commonly develop from cells of follicular origin. The most common differentiated thyroid cancers (DTC are papillary and follicular carcinomas. Coexistence of two different histological types of primary follicular thyroid neoplasm is a rare condition. There are previous reports of concomitant medullary and papillary thyroid cancers. However, there is scarce data about the simultaneous occurrence of the two different histological types of primary follicular thyroid tumors and this is the first study on that subject. Material and Method: From January 2007 to September 2014, our institutional database was reviewed for patients who underwent thyroid surgery for various indications. Medical records and cytopathology reports of those patients were examined retrospectively. Simultaneous neoplasms of follicular origin were noted. Results: A total of 3.700 patients were operated. Histopathological examination revealed a benign pattern in 2.686 (73% patients and a malignant pattern in 1.014 (27% patients. Among the patients with the diagnosis of DTC, only 20 (1.9% had a concomitant neoplasm within the same thyroid gland. Discussion: Such simultaneous tumors may be a part of a familial tumor syndrome or an unidentified novel gene mutation playing role in the pathogenesis of more than one type of tumor. Based on the current evidence, the synchronous occurrence of those neoplasms in a given patient is likely coincidental in the literature. Further studies on larger patient population with standardized genetic characterization are needed.