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Sample records for surface nis levels

  1. Microarray analysis of genes associated with cell surface NIS protein levels in breast cancer.

    Science.gov (United States)

    Beyer, Sasha J; Zhang, Xiaoli; Jimenez, Rafael E; Lee, Mei-Ling T; Richardson, Andrea L; Huang, Kun; Jhiang, Sissy M

    2011-10-11

    Na+/I- symporter (NIS)-mediated iodide uptake allows radioiodine therapy for thyroid cancer. NIS is also expressed in breast tumors, raising potential for radionuclide therapy of breast cancer. However, NIS expression in most breast cancers is low and may not be sufficient for radionuclide therapy. We aimed to identify biomarkers associated with NIS expression such that mechanisms underlying NIS modulation in human breast tumors may be elucidated. Published oligonucleotide microarray data within the National Center for Biotechnology Information Gene Expression Omnibus database were analyzed to identify gene expression tightly correlated with NIS mRNA level among human breast tumors. NIS immunostaining was performed in a tissue microarray composed of 28 human breast tumors which had corresponding oligonucleotide microarray data available for each tumor such that gene expression associated with cell surface NIS protein level could be identified. NIS mRNA levels do not vary among breast tumors or when compared to normal breast tissues when detected by Affymetrix oligonucleotide microarray platforms. Cell surface NIS protein levels are much more variable than their corresponding NIS mRNA levels. Despite a limited number of breast tumors examined, our analysis identified cysteinyl-tRNA synthetase as a biomarker that is highly associated with cell surface NIS protein levels in the ER-positive breast cancer subtype. Further investigation on genes associated with cell surface NIS protein levels within each breast cancer molecular subtype may lead to novel targets for selectively increasing NIS expression/function in a subset of breast cancers patients.

  2. Microarray analysis of genes associated with cell surface NIS protein levels in breast cancer

    Directory of Open Access Journals (Sweden)

    Richardson Andrea L

    2011-10-01

    Full Text Available Abstract Background Na+/I- symporter (NIS-mediated iodide uptake allows radioiodine therapy for thyroid cancer. NIS is also expressed in breast tumors, raising potential for radionuclide therapy of breast cancer. However, NIS expression in most breast cancers is low and may not be sufficient for radionuclide therapy. We aimed to identify biomarkers associated with NIS expression such that mechanisms underlying NIS modulation in human breast tumors may be elucidated. Methods Published oligonucleotide microarray data within the National Center for Biotechnology Information Gene Expression Omnibus database were analyzed to identify gene expression tightly correlated with NIS mRNA level among human breast tumors. NIS immunostaining was performed in a tissue microarray composed of 28 human breast tumors which had corresponding oligonucleotide microarray data available for each tumor such that gene expression associated with cell surface NIS protein level could be identified. Results and Discussion NIS mRNA levels do not vary among breast tumors or when compared to normal breast tissues when detected by Affymetrix oligonucleotide microarray platforms. Cell surface NIS protein levels are much more variable than their corresponding NIS mRNA levels. Despite a limited number of breast tumors examined, our analysis identified cysteinyl-tRNA synthetase as a biomarker that is highly associated with cell surface NIS protein levels in the ER-positive breast cancer subtype. Conclusions Further investigation on genes associated with cell surface NIS protein levels within each breast cancer molecular subtype may lead to novel targets for selectively increasing NIS expression/function in a subset of breast cancers patients.

  3. Oral vaccine of Lactococcus lactis harbouring pandemic H1N1 2009 haemagglutinin1 and nisP anchor fusion protein elevates anti-HA1 sIgA levels in mice.

    Science.gov (United States)

    Joan, Stella Siaw Xiu; Pui-Fong, Jee; Song, Adelene Ai-Lian; Chang, Li-Yen; Yusoff, Khatijah; AbuBakar, Sazaly; Rahim, Raha Abdul

    2016-05-01

    An oral lactococcal-based vaccine which haboured the haemagglutinin1 (HA1) antigen fused to nisP anchor protein for the purpose of surface displaying the HA1 antigen was developed against H1N1 virus. Recombinant L. lactis strains expressed HA1-nisP fusion proteins when induced with nisin, as confirmed through western blotting. However, immunofluorescense did not detect any surface-displayed proteins, suggesting that the protein was either unsuccessfully translocated or improperly displayed. Despite this, oral administration of recombinant L. lactis strains to BALB/c mice revealed that significant levels of anti-HA1 sIgA antibodies were detected in mice fecal suspension samples of mice group NZ9000 (pNZ:HN) when compared to the negative control NZ9000 (pNZ8048) group. Specific anti-HA1 sIgA antibodies were locally produced and live recombinant lactococcal vaccine was able to elicit humoral response of BALB/c mice despite unsuccessful surface display of the HA1 epitope.

  4. Hydrothermal assisted decoration of NiS2and CoS nanoparticles on the reduced graphene oxide nanosheets for sunlight driven photocatalytic degradation of azo dye: Effect of background electrolyte and surface charge.

    Science.gov (United States)

    Borthakur, Priyakshree; Das, Manash R

    2018-04-15

    The semiconductor NiS 2 nanoparticles with an average size of 10 ± 0.317 nm were successfully deposited on the reduced graphene oxide (rGO) sheets by simple hydrothermal method. The synthesized nanocomposite was characterized by various instrumental techniques like XRD, FTIR, FESEM, EDX, HRTEM, fluorescence spectrophotometer analysis. In this study we mainly focus on the determination of the surface potential values of NiS 2 -rGO and CoS-rGO nanocomposite under different experimental conditions and evaluated the photodegradation efficiency towards azo dye Congo Red (CR) molecule under natural sunlight irradiation. We found that the surface charge (zeta potential) of the both nanocomposite materials in presence of different inorganic ions salt solutions like NaCl, NaNO 3 , Na 2 SO 4 , MgCl 2 , CaCl 2 etc. is varied based on the polarizability of the ions as well as pH of the suspension. Different inorganic ions present in the catalyst suspension can alter the surface charge of the catalyst by forming a double layer around the molecule and thus change the electrostatic interaction between the dye molecule and the catalyst surface which change the degradation efficiency of the photocatalyst towards CR molecule. The photocatalytic efficiency of NiS 2 -rGO and CoS-rGO nanocomposite towards CR degradation was found to be 97.03% and 88.03% in 40 min, respectively under same experimental condition whereas NiS 2 and CoS nanoparticles without support exhibited photodegradation efficiency 57.89% and 50.52%, respectively. The observed improved photocatalytic activity of the metal sulfide-rGO nanocomposite results the presence of synergistic effect between the metal sulfide nanoparticles and the rGO sheets of the photocatalysts which inhibits the recombination rate of photogenerated electrons and holes. The mechanism of the degradation process was investigated by photoluminescence study in presence of terephthalic acid and also quenching experiment in presence of

  5. The EUCLID-NIS Mission

    Science.gov (United States)

    Balcells, M.

    Obtaining a measure of the baryonic acoustic oscillations (BAO) is among the top goals of cosmology in the beginning of the twenty-first century. Detection of BAOs offers the possibility to test the standard cosmological model, by providing strong constraints on the equation of state of dark energy. The EUCLID-NIS mission proposes to measure BAOs by mapping the 3D distribution of baryons at intermediate redshift, 1 micromirror devices (DMD) from Texas Instruments.

  6. Iodide handling disorders (NIS, TPO, TG, IYD).

    Science.gov (United States)

    Targovnik, Héctor M; Citterio, Cintia E; Rivolta, Carina M

    2017-03-01

    Iodide Handling Disorders lead to defects of the biosynthesis of thyroid hormones (thyroid dyshormonogenesis, TD) and thereafter congenital hypothyroidism (CH), the most common endocrine disease characterized by low levels of circulating thyroid hormones. The prevalence of CH is 1 in 2000-3000 live births. Prevention of CH is based on prenatal diagnosis, carrier identification, and genetic counseling. In neonates a complete diagnosis of TD should include clinical examination, biochemical thyroid tests, thyroid ultrasound, radioiodine or technetium scintigraphy and perchlorate discharge test (PDT). Biosynthesis of thyroid hormones requires the presence of iodide, thyroid peroxidase (TPO), a supply of hydrogen peroxide (DUOX system), an iodine acceptor protein, thyroglobulin (TG), and the rescue and recycling of iodide by the action of iodotyrosine deiodinase or iodotyrosine dehalogenase 1 (IYD or DEHAL1). The iodide transport is a two-step process involving transporters located either in the basolateral or apical membranes, sodium iodide symporter (NIS) and pendrin (PDS), respectively. TD has been linked to mutations in the solute carrier family 5, member 5 transporter (SLC5A5, encoding NIS), solute carrier family 26, member 4 transporter (SLC26A4, encoding PDS), TPO, DUOX2, DUOXA2, TG and IYD genes. These mutations produce a heterogeneous spectrum of CH, with an autosomal recessive inheritance. Thereafter, the patients are usually homozygous or compound heterozygous for the gene mutations and the parents, carriers of one mutation. In the last two decades, considerable progress has been made in identifying the genetic and molecular causes of TD. Recent advances in DNA sequencing technology allow the massive screening and facilitate the studies of phenotype variability. In this article we included the most recent data related to disorders caused by mutations in NIS, TPO, TG and IYD. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. The distribution of work performed on a NIS junction

    DEFF Research Database (Denmark)

    Santos, Jaime Eduardo Vieira da Silva Moutinho; Ribeiro, Pedro; Kirchner, Stefan

    2016-01-01

    results are based on an equivalence between the dynamics of the NIS junction and that of an assembly of two-level systems subjected to a circularly polarised field, for which we can determine the work-characteristic function exactly. The average work dissipated by the NIS junction, as well as its...... fluctuations, are determined. From the work characteristic function, we also compute the work probability-distribution and show that it does not have a Gaussian character. Our results allow for a direct experimental test of the Crooks–Tasaki fluctuation relation.......We propose an experimental setup to measure the work performed in a normal-metal/insulator/superconducting (NIS) junction, subjected to a voltage change and in contact with a thermal bath. We compute the performed work and argue that the associated heat release can be measured experimentally. Our...

  8. Constructing Multifunctional Metallic Ni Interface Layers in the g-C3N4Nanosheets/Amorphous NiS Heterojunctions for Efficient Photocatalytic H2Generation.

    Science.gov (United States)

    Wen, Jiuqing; Xie, Jun; Zhang, Hongdan; Zhang, Aiping; Liu, Yingju; Chen, Xiaobo; Li, Xin

    2017-04-26

    The construction of exceptionally robust and high-quality semiconductor-cocatalyst heterojunctions remains a grand challenge toward highly efficient and durable solar-to-fuel conversion. Herein, novel graphitic carbon nitride (g-C 3 N 4 ) nanosheets decorated with multifunctional metallic Ni interface layers and amorphous NiS cocatalysts were fabricated via a facile three-step process: the loading of Ni(OH) 2 nanosheets, high-temperature H 2 reduction, and further deposition of amorphous NiS nanosheets. The results demonstrated that both robust metallic Ni interface layers and amorphous NiS can be utilized as electron cocatalysts to markedly boost the visible-light H 2 evolution over g-C 3 N 4 semiconductor. The optimized g-C 3 N 4 -based photocatalyst containing 0.5 wt % Ni and 1.0 wt % NiS presented the highest hydrogen evolution of 515 μmol g -1 h -1 , which was about 2.8 and 4.6 times as much as those obtained on binary g-C 3 N 4 -1.0%NiS and g-C 3 N 4 -0.5%Ni, respectively. Apparently, the metallic Ni interface layers play multifunctional roles in enhancing the visible-light H 2 evolution, which could first collect the photogenerated electrons from g-C 3 N 4 , and then accelerate the surface H 2 -evolution reaction kinetics over amorphous NiS cocatalysts. More interestingly, the synergetic effects of metallic Ni and amorphous NiS dual-layer electron cocatalysts could also improve the TEOA-oxidation capacity through upshifting the VB levels of g-C 3 N 4 . Comparatively speaking, the multifunctional metallic Ni layers are dominantly favorable for separating and transferring photoexcited charge carriers from g-C 3 N 4 to amorphous NiS cocatalysts owing to the formation of Schottky junctions, whereas the amorphous NiS nanosheets are mainly advantageous for decreasing the thermodynamic overpotentials for surface H 2 -evolution reactions. It is hoped that the implantation of multifunctional metallic interface layers can provide a versatile approach to enhance the

  9. The Sodium Iodide Symporter (NIS) and Potential Regulators in Normal, Benign and Malignant Human Breast Tissue

    Science.gov (United States)

    Ryan, James; Curran, Catherine E.; Hennessy, Emer; Newell, John; Morris, John C.; Kerin, Michael J.; Dwyer, Roisin M.

    2011-01-01

    Introduction The presence, relevance and regulation of the Sodium Iodide Symporter (NIS) in human mammary tissue remains poorly understood. This study aimed to quantify relative expression of NIS and putative regulators in human breast tissue, with relationships observed further investigated in vitro. Methods Human breast tissue specimens (malignant n = 75, normal n = 15, fibroadenoma n = 10) were analysed by RQ-PCR targeting NIS, receptors for retinoic acid (RARα, RARβ), oestrogen (ERα), thyroid hormones (THRα, THRβ), and also phosphoinositide-3-kinase (PI3K). Breast cancer cells were treated with Retinoic acid (ATRA), Estradiol and Thyroxine individually and in combination followed by analysis of changes in NIS expression. Results The lowest levels of NIS were detected in normal tissue (Mean(SEM) 0.70(0.12) Log10 Relative Quantity (RQ)) with significantly higher levels observed in fibroadenoma (1.69(0.21) Log10RQ, pbreast tissue (1.18(0.07) Log10RQ, pbreast tissue, the highest level was detected in fibroadenoma. The data presented supports a role for retinoic acid and estradiol in mammary NIS regulation in vivo, and also highlights potential thyroidal regulation of mammary NIS mediated by thyroid hormones. PMID:21283523

  10. hNIS-IRES-eGFP Dual Reporter Gene Imaging

    Directory of Open Access Journals (Sweden)

    Jiantu Che

    2005-04-01

    Full Text Available The human and rodent sodium iodide symporters (NIS have recently been cloned and are being investigated as potential therapeutic and reporter genes. We have extended this effort by constructing an internal ribosomal entry site (IRES-linked human NIS (hNIS-enhanced green fluorescent protein (eGFP hybrid reporter gene for both nuclear and optical imaging. A self-inactivating retroviral vector, termed pQCNIG, containing hNIS-IRES-eGFP dual reporter gene, driven by a constitutive CMV promoter, was constructed and used to generate RG2-pQCNIG cells and RG2-pQCNIG tumors. 131I-iodide and 99mTcO4-pertechnetate accumulation studies plus fluorescence microscopy and intensity assays were performed in vitro, and gamma camera imaging studies in RG2-pQCNIG and RG2 tumor-bearing athymic rats were performed. RG2-pQCNIG cells expressed high levels of hNIS protein and showed high intensity of eGFP fluorescence compared with RG2 wild-type cells. RG2-pQCNIG cells accumulated Na131I and 99mTcO4– to a 50:1 and a 170:1 tissue/medium ratio at 10 min, compared with 0.8:1.2 tissue/medium ratio in wild-type RG2 cells. A significant correlation between radiotracer accumulation and eGFP fluorescence intensity was demonstrated. RG2-pQCNIG and RG2 tumors were readily differentiated by in vivo gamma camera imaging; radiotracer uptake increased in RG2-pQCNIG but declined in RG2 tumors over the 50-min imaging period. Stomach and thyroid were the major organs of radionuclide accumulation. The IRES-linked hNIS-eGFP dual reporter gene is functional and stable in transduced RG2-pQCNIG cells. Optical and nuclear imaging of tumors produced from these cell lines provides the opportunity to monitor tumor growth and response to therapy. These studies indicate the potential for a wider application of hNIS reporter imaging and translation into patient studies using radioisotopes that are currently available for human use for both SPECT and PET imaging.

  11. Training builds organizations in NIS.

    Science.gov (United States)

    1995-01-01

    The Centre for Development and Population Activities (CEDPA) has been using workshops to train nongovernmental organization (NGOs) managers in the Newly Independent States (NIS) of the former Soviet Union over the past year (1994). 7 were held in Ukraine and Moldova (with support from the Counterpart Foundation under an agreement with the US Agency for International Development), that covered skills for effective training and project proposal writing. The managers represented a variety of fields: environment, health, family planning, social services, consumer affairs, youth needs, women's programs, disabilities, education, and culture. Ralph Stone is CEDPA training director. Adrienne Allison, vice president of CEDPA, is a member of the Volunteer Executive Service Team (VEST), which conducts study tours to the area. A collaborative effort of the US government and the US private sector, VEST supports the development of the independent, civil, and services sectors of the new countries. In Washington, CEDPA conducted workshops on women's reproductive health (February and March) and on business policy and regulation (November and December) for Russians involved in family planning and small business development respectively. These were organized in conjunction with the University of California at Riverside and the Academy for Educational Development.

  12. Au-controlled enhancement of photoluminescence of NiS nanostructures synthesized via a microwave-assisted hydrothermal technique

    Energy Technology Data Exchange (ETDEWEB)

    Linganiso, Ella Cebisa [DST/CSIR Nanotech Innovation Centre, National Centre for Nano-structured Materials, Council for Scientific and Industrial Research, PO Box 395, Pretoria 0001 (South Africa); Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, Wits, 2050 Johannesburg (South Africa); Mwakikunga, Bonex Wakufwa, E-mail: bmwakikunga@csir.co.za [DST/CSIR Nanotech Innovation Centre, National Centre for Nano-structured Materials, Council for Scientific and Industrial Research, PO Box 395, Pretoria 0001 (South Africa); Department of Physics and Biochemical Sciences, The Polytechnic of the University of Malawi, Private Bag 303, Chichiri, Blantyre 0003 (Malawi); Mhlanga, Sabelo Dalton [Department of Applied Chemistry, University of Johannesburg, PO Box 17011, Doornfontein, 2028 Johannesburg (South Africa); Coville, Neil John [Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, Wits, 2050 Johannesburg (South Africa); DST/NRF Centre of Excellence in Strong Materials, University of the Witwatersrand, Private Bag 3, Wits, 2050 Johannesburg (South Africa)

    2014-11-15

    Nickel sulphide (NiS) nanostructures decorated with gold (Au) nanoparticles (NPs) were synthesized via a microwave-assisted hydrothermal technique. Binary phase NiS (α and β) crystalline nanostructures, bare, and decorated with Au NPs were obtained and confirmed by X-ray diffraction (XRD) studies. TEM analysis revealed that the NiS nanostructures were of various shapes. A quantum confinement effect was confirmed by the blue shift PL emissions and high optical energy band gap observed for the as-synthesized sample. A threefold light emission enhancement due to Au NP coatings was obtained when Au metal NP decoration concentrations was varied from 1% to 10%. These enhancements were attributed to the surface plasmon resonance (SPR) excitation of the surface decorated metal NPs which results in an increased rate of spontaneous emission. The PL enhancement factor was observed to vary at different NiS emissions as well as with the size of the Au NPs. The effect of metal NP decoration on the PL emission of NiS is to the best of our knowledge, presented for the first time. - Highlights: • Binary phase NiS decorated with gold nanoparticles. • Quantum confinement effect confirmed by PL analysis. • PL enhancement depending more on particle size distribution. • Effect of gold on NiS PL is to the best of our knowledge reported for the first time.

  13. SMOKING HABITS OF NIS PRESCHOOL CHILDREN'S PARENTS

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    Miodrag Vucic

    2007-10-01

    Full Text Available The greatest threat for the public health in Serbia is definitively smoking. 1,3 billion of people in the world are smokers and 4,9 million of death at the global level are direct consequences of smoking. If this smoking rhythm continues until 2020. the number of deaths caused by smoking will have been doubled. There are 4000 identified substances in the tobacco smoke, 50 of which have been proven to be carcinogenic. Nowdays, 14000 to 15000 young people in the developed countries and 68000-84000 in the underdeveloped contries begin to smoke. 700 millions of children, the half of the whole children population, are exposed to the passive smoking.The prevalence of smoking in Serbia, although reduced by 6,9% compared to 2000 is still very high and makes 33,6% of the whole population (38,1% of men and 29,9% of women.The aim of this study was to investigate the smoking habits of preschool children's parents, motivated by the fact that the children of that age are highly sensitive and susceptible to the toxic influence of tobacco smoke, but also to check the necessity for an aggressive public health programme implementation in the aimed populations.This research, as a cross-sectional stady, is carried out among preschool children's parents, children being 4 to 6 years old that attend nursery schools in Nis.The prevalence of smoking in preschool children's parents is extremely high, and makes 46% (45,1% of men and 46,9% of women. Having taken into consideration the parental role in upbringing and education of children, as well as the influence of passive smoking, the main conclusion is that the children's health is seriously endangered. Education, making new and maintaining already existing programmes and legal obligations considering smoking are significant steps for reducing smoking and promoting health.

  14. Effect of thyroid statuses on sodium/iodide symporter (NIS gene expression in the extrathyroidal tissues in mice

    Directory of Open Access Journals (Sweden)

    Harun-Or-Rashid

    2010-06-01

    Full Text Available Abstract Background Iodide that is essential for thyroid hormone synthesis is actively transported into the thyroid follicular cells via sodium/iodide symporter (NIS protein in vertebrates. It is well known that NIS expression in thyroid is regulated by the thyroid statuses mainly through thyroid stimulating hormone (TSH. Although NIS mRNA expressions in extrathyroidal tissues have been qualitatively reported, their regulation by thyroid statuses has not been well clarified. Methods Male ICR mice aged four weeks were assigned into three groups (control, hypothyroid, and hyperthyroid. Hypothyroid group of mice were treated with 0.02% methimazole in drinking water and hyperthyroid group of mice received intraperitoneal injection (4 μg L-T4 twice a week for four weeks. NIS mRNA expression levels in the tissues were evaluated using Northern blot hybridization and quantitative real-time RTPCR (qPCR. Additionally, end-point RTPCR for the thyroid follicular cell-characteristic genes (TSH receptor, TSHR; thyroid transcription factor-1, TTF1; and paired box gene 8, Pax8 was carried out. Results By Northern blot analysis, NIS mRNA was detected in thyroid and stomach. In addition to these organs, qPCR revealed the expression also in the submandibular gland, colon, testis, and lung. Expression of NIS mRNA in thyroid was significantly increased in hypothyroid and decreased in hyperthyroid group. Trends of NIS mRNA expression in extrathyroidal tissues were not in line with that in the thyroid gland in different thyroid statuses. Only in lung, NIS mRNA was regulated by thyroid statuses but in opposite way compared to the manner in the thyroid gland. There were no extrathyroidal tissues that expressed all three characteristic genes of thyroid follicular cells. Conclusions NIS mRNA expression in the thyroid gland was up-regulated in hypothyroid mice and was down-regulated in hyperthyroid mice, suggesting that NIS mRNA in the thyroid gland is regulated by

  15. IAEA co-ordinated technical support programme to the NIS

    International Nuclear Information System (INIS)

    Olsen, R.; Murakami, K.; Blacker, C.; Sharma, S.K.

    1999-01-01

    With most Newly Independent States (NIS) of the former Soviet Union becoming parties to the Non-Proliferation Treaty as Non-Nuclear Weapon States, there has been an acute need in these states for considerable assistance for the establishment of the necessary structure and resources to ensure that their commitments to non-proliferation are fully implemented in a timely manner. A number of IAEA Member States have offered and are now providing assistance to the NIS on a bilateral level to set up an appropriate State System of Accounting and Control (SSAC) which includes Import/Export Control and Physical Protection of Nuclear Material in each state. The IAEA and these Member States established the Co-ordinated Technical Support Programme (CTSP) to ensure that the support given to the NIS was done in a co-ordinated and transparent manner and to avoid duplication of effort. The IAEA has played a coordinating role for the past 5 years by helping to identify detailed needs in individual States, by providing a platform for Member States to identify areas where they could provide the optimum support, and in developing and preparing the Co-ordinated Technical Support Plans. The IAEA organises annual meetings in Vienna attended by all donor and recipient countries to review the focus and implementation status of the co-ordinated technical support activities. A position statement is made by each donor and recipient country, and views and experiences are exchanged. The contents of the CTSPs and the role of the Agency in monitoring the progress of the individual tasks are reviewed in this paper. A summary comparing the implementation status of the Programme by each country is presented. (author)

  16. Imaging of adenovirus-mediated expression of human sodium iodide symporter (hNIS) by 99mTcO4 scan in mice

    International Nuclear Information System (INIS)

    Lee, Won Woo; Moon, D. H.; Park, S. Y.; Jin, J.; Kim, S. J.; Lee, H.

    2002-01-01

    We have evaluated the feasibility of human sodium iodide symporter (hNIS) as a reporter gene by 99m TcO 4 scan in vivo. Recombinant adenovirus encoding hNIS (Rad-hNIS) gene was introduced to FRO cell. hNIS expression was assessed by western blot and 99m TcO 4 uptake in vitro. 99m TcO 4 scan were obtained in BALB/c mice 48 hrs post injection of Tris buffer, Rad-hNIS (1x10 9 or 2x10 8 pfu), or Rad-LacZ (1x10 9 pfu) via the tail vein (n=5-7 for each group). Biodistribution study and RT-PCR were performed. A series of 99m TcO 4 scans were obtained in 2 mice until 21 days post Rad-hNIS injection. FRO readily expressed hNIS protein and incorporated significantly higher level of 99m TcO 4 in vitro. With 99m TcO 4 scan, prominent hepatic uptake was observed only in the mice with 1x10 9 pfu of Rad-hNIS. Liver/lung ratio was increased in this group from 15 (5.7±2.5) till 60 min(6.7±3.6) (p 99m TcO 4 uptake (22.7±11.2 %ID/g) and hNIS mRNA expression were exclusively noticed in livers of this group. The persistent hepatic uptake was observed for up one week. NaClO 4 inhibited the hepatic uptake of 99m TcO 4 . hNIS holds a promising potential as an effective reporter gene for noninvasive/repeated imaging in combination with 99m TcO 4

  17. Towards a biochemical and structural characterisation of the sodium-iodide sym-porter (Nis)

    International Nuclear Information System (INIS)

    Darrouzet, E.; Marcellin, D.; Huc, S.; Quemeneur, E.; Pourcher, T.

    2006-01-01

    Iodide is essential for thyroid hormone biosynthesis in mammals, and therefore for the control of cell metabolism and the development of the central nervous system in the foetus and newborns, but is relatively scarce element in the environment. To ensure its accumulation, the thyroid gland has evolved a remarkably efficient system, the sodium-iodide sym-porter (NIS), that was first characterized at the molecular level 10 years ago (1). NIS is an intrinsic protein mainly located in the basolateral membrane of thyroid follicular cells where it actively transports iodide ions using the sodium gradient as a driving force (2,3). In addition, this transporter has been found in lactating mammary gland, stomach, and salivary glands, and its mRNA was detected in brain, ovaries, testis. To date, the physiological role of NIS in these organs is not yet identified (3,4).The capacity of NIS to mediate the accumulation of radioactive iodide has been exploited for many years in the diagnosis of thyroid cancer as well as for the detection and radiotherapy of derived metastases. Moreover, the presence of NIS in some breast tumours and the possibility to express it by targeted gene therapy in tumour cells where it is not naturally present could also widen its medical application (4-7). In case of accidental contamination, NIS would also be responsible for accumulation of radioisotopes in the thyroid and for their transfer to the milk and the newborn, eventually causing thyroid cancers. This has motivated our research program in the perspective of designing novel specific therapeutics. During the last decade, the gene encoding the thyroid NIS has been identified and sequenced in various species including rat, mouse and human (1, 8). It was also demonstrated that the protein expression and activity are highly regulated both at the transcriptional and post-translational levels (3). A preliminary topological mode could be drawn from the protein sequence. It proposes a general

  18. Controlled synthesis of NiS nanoparticle/CdS nanowire heterostructures via solution route and their optical properties

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Shancheng, E-mail: yansc@njupt.edu.cn [School of Geography and Biological Information, Nanjing University of Posts and Telecommunications, Nanjing 210046 (China); National Laboratory of Solid State Microstructures, School of Electronic Science and Engineering, Nanjing University, Nanjing 210093 (China); Shi, Yi [National Laboratory of Solid State Microstructures, School of Electronic Science and Engineering, Nanjing University, Nanjing 210093 (China); Sun, Litao [Key Lab of MEMS of Ministry of Education, Southeast University, Si Pai Lou 2, Nanjing 210096 (China); Xiao, Zhongdang; Sun, Bo [State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Si Pai Lou 2, Nanjing 210096 (China); Xu, Xin [School of Geography and Biological Information, Nanjing University of Posts and Telecommunications, Nanjing 210046 (China)

    2013-01-01

    Graphical abstract: The novel heterostructure of NiS nanoparticle (NP)/CdS nanowire (NW) was successfully fabricated by a two-step chemical solution method. The novel catalyst-assisted growth mechanism has been proposed according to the experimental results. Highlights: Black-Right-Pointing-Pointer We do not need the surface pretreatments to introduce groups' interconnectivity. Black-Right-Pointing-Pointer There are cation vacancies on the surface, which allows foreign ones to dissolve. Black-Right-Pointing-Pointer A novel catalyst-assisted growth mechanism of the heterostructure has been proposed. Black-Right-Pointing-Pointer In addition, no NiS NP/CdS NW heterostructure has been reported until now. - Abstract: In the present study, we have successfully synthesized the novel heterostructure of NiS nanoparticle (NP)/CdS nanowire (NW) through solution approach. The first step, CdS nanowires were synthesized by a convenient solvothermal route. Then, NiS nanoparticles were grown on the surface of CdS nanowires in a chemical solution of NiCl{sub 2}{center_dot}6H{sub 2}O and anhydrous ethanol at 200 Degree-Sign C. The new catalyst-assisted growth mechanism of the NiS NP/CdS NW heterostructure has been tentatively discussed on the basis of experimental results. A detailed study of the effect of experimental parameters, such as reaction time, reaction temperature, and reaction solvent are also studied. The as-prepared products are characterized by field-emission scan electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS), and their optical properties are measured by Raman spectra and PL spectra. Furthermore, using CdS nanowires and NiS NP/CdS NW heterostructure as examples, our study suggests that this general method can be employed for construction of other semiconductor heterostructures with novel properties.

  19. HCUP National (Nationwide) Inpatient Sample (NIS) - Restricted Access File

    Data.gov (United States)

    U.S. Department of Health & Human Services — The NIS is the largest publicly available all-payer inpatient care database in the United States. It contains data from approximately 8 million hospital stays each...

  20. Radiation Level Changes at RAM Package Surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Opperman, Erich [Washington Savannah River Company; Hawk, Mark B [ORNL; Kapoor, Ashok [U.S. Department of Energy, Office of Packaging and Transportation; Natali, Ronald [R. B. Natali Consulting, Inc.

    2010-01-01

    This paper will explore design considerations required to meet the regulations that limit radiation level variations at external surfaces of radioactive material (RAM) packages. The radiation level requirements at package surfaces (e.g. TS-R-1 paragraphs 531 and 646) invoke not only maximum radiation levels, but also strict limits on the allowable increase in the radiation level during transport. This paper will explore the regulatory requirements by quantifying the amount of near surface movement and/or payload shifting that results in a 20% increase in the radiation level at the package surface. Typical IP-2, IP-3, Type A and Type B packaging and source geometries will be illustrated. Variations in surface radiation levels are typically the result of changes in the geometry of the surface due to an impact, puncture or crush event, or shifting and settling of radioactive contents.

  1. Hexanuclear [Ni6L12] metallacrown framework consisting of NiS4 square-planar and NiS5 square-pyramidal building blocks

    NARCIS (Netherlands)

    Angamuthu, R.; Kooijman, H.; Lutz, M.; Spek, A.L.; Bouwman, E.

    2007-01-01

    The hexanuclear [Ni6L12] (2) wheel-type cluster adopts an unusual structural motif whereby four NiS4 square-planar and two NiS5 square-pyramidal units are conjoined by edge sharing; the NiS5 units resemble the Ni centre of the inactive state in the [NiFe] hydrogenase.

  2. MISR Level 2 Surface parameters V002

    Data.gov (United States)

    National Aeronautics and Space Administration — This Level 2 Land Surface product contains information on land directional reflectance properties,albedos(spectral & PAR integrated),FPAR,asssociated radiation...

  3. 'NiNis': Youth in Argentina who Neither Work nor Study. A Social Integration Deficit

    Directory of Open Access Journals (Sweden)

    Lidia de la Torre

    2017-01-01

    Full Text Available This study aims to assess the extent to which vulnerability in household material living conditions affects the institutional integration of young people of Argentina. We worked with a random sample of 4,855 youth aged between 18 and 25. It was observed that 66% of those who neither study nor work live in households having a low or very low socioeconomic status, with 4 out of 10 of these youth residing in shantytowns or slums and with half of them failing to complete high school. Harsh environments create a vicious circle of persistent passivity and isolation. However, the comparison between the NiNis and the working segment allowed us to conclude that similar household levels of socio-economic vulnerability are not necessarily sufficient to explain the situation of social disaffiliation found in these youth NiNis.

  4. Facile synthesis of NiS anchored carbon nanofibers for high-performance supercapacitors

    Science.gov (United States)

    Xu, Jinling; Zhang, Li; Xu, Guancheng; Sun, Zhipeng; Zhang, Chi; Ma, Xin; Qi, Chunling; Zhang, Lu; Jia, Dianzeng

    2018-03-01

    Transition metal sulfide compounds with carbon materials are promising for high-performance supercapacitors. Carbon nanofibers (CNFs) wrapped with NiS nanoparticles were herein obtained through electrospinning and calcination. NiS nanoparticles in composite nanofibers are covered by a layer of graphitic carbon, which not only increase the conductivity but also provide active regions for nanoparticle growth to prevent aggregation. The CNFs-NiS electrode has high specific capacity of 177.1 mAh g-1 at 1 A g-1 (0.41 mAh cm-2 at a current density of 2.3 mA cm-2) and long-term cycling stability, with 88.7% capacitance retention after 5000 cycles. The excellent electrochemical activity may be attributed to the accessible specific surface, unique porous structure of CNFs and high specific capacitance of NiS. In addition, the asymmetric supercapacitor has an enhanced volumetric energy density of 13.32 mWh cm-3 at a volumetric power density of 180 mW cm-3 and high cycling stability, with 89.5% capacitance retention after 5000 cycles. It also successfully lights up a light-emitting diode. The CNFs-NiS composite has significant potential applications in supercapacitor.

  5. HSP70-Inducible hNIS-IRES-eGFP Reporter Imaging: Response to Heat Shock

    Directory of Open Access Journals (Sweden)

    Jiantu Che

    2007-11-01

    Full Text Available A retroviral vector pQHSP70/hNIS-IRES-eGFP (pQHNIG70 was constructed containing the hNIS-IRES-eGFP dual-reporter genes under the control of an inducible human heat shock protein (HSP70 promoter and RG2-pQHSP70/hNIS-IRES-eGFP (RG2-pQHNIG70 transduced cells were generated. Heat-induced expression of both reporter genes in RG2-pQHNIG70 cells was validated by enhanced green fluorescent protein (eGFP fluorescence-activated cell sorter, in vitro radiotracer assays, and immunoblot and immunocytochemistry. A 2.2- to 6.1-fold (131I−, a 6.1- to 14.4-fold (99mTcO4−, and a 5.1- to 39-fold (fluorescence increase above baseline was observed in response to graded hyperthermia (39–43°C. Increases in eGFP fluorescence and radiotracer uptake were first noted at 6 hours, reached a maximum at 24 hours, and fell toward baseline at 72 hours. A stable ratio of radiotracer uptake to eGFP fluorescence and to heat shock protein (HSP70 protein was demonstrated over a wide range of expression levels, induced by different levels of heating. We also demonstrate that the local application of heat on RG2-pQHNIG70 xenografts can effectively induce hNIS and eGFP gene expression in vivo and that this expression can be efficiently visualized by fluorescence, scintigraphic, and micro–positron emission tomography imaging. Endogenous HSP70 protein and reporter expression was confirmed by postmortem tissue evaluations (immunoblot and immunohistochemistry. The pQHNIG70 reporter system can be used to study stress and drug responses in transduced cells and tissues.

  6. DEVELOPMENT OF A SCREENING APPROACH TO DETECT THYROID DISRUPTING CHEMICALS THAT INHIBIT THE HUMAN SODIUM IODIDE SYMPORTER (NIS)

    Data.gov (United States)

    U.S. Environmental Protection Agency — Data pertaining to a NIS-expressing cell line, hNIS-HEK293T-EPA, and its screening capabilities for determining inhibitors of NIS-mediated iodide uptake. This...

  7. The presence of modifiable residues in the core peptide part of precursor nisin is not crucial for precursor nisin interactions with NisB- and NisC.

    Directory of Open Access Journals (Sweden)

    Rustem Khusainov

    Full Text Available Precursor nisin is a model posttranslationally modified precursor lantibiotic that can be structurally divided into a leader peptide sequence and a modifiable core peptide part. The nisin core peptide clearly plays an important role in the precursor nisin-nisin modification enzymes interactions, since it has previously been shown that the construct containing only the nisin leader sequence is not sufficient to pull-down the nisin modification enzymes NisB and NisC. Serines and threonines in the core peptide part are the residues that NisB specifically dehydrates, and cysteines are the residues that NisC stereospecifically couples to the dehydrated amino acids. Here, we demonstrate that increasing the number of negatively charged residues in the core peptide part of precursor nisin, which are absent in wild-type nisin, does not abolish binding of precursor nisin to the modification enzymes NisB and NisC, but dramatically decreases the antimicrobial potency of these nisin mutants. An unnatural precursor nisin variant lacking all serines and threonines in the core peptide part and an unnatural precursor nisin variant lacking all cysteines in the core peptide part still bind the nisin modification enzymes NisB and NisC, suggesting that these residues are not essential for direct interactions with the nisin modification enzymes NisB and NisC. These results are important for lantibiotic engineering studies.

  8. Cloning of nis gene and Nisin purification from Lactococcus lactis ...

    African Journals Online (AJOL)

    The purified nisin by chloroform extraction was analyzed on 20% SDS-PAGE and gave sharp band at ~ 3.4 kDa. The 3 dimension structure of the purified Nisin was studied by CPHModels as pdb with chimera program. Keywords: Lactococcus lactis, nis cloning, 16S rRNA, chloroform extraction and SDS-PAGE

  9. Dėl žem. jeĩnis

    Directory of Open Access Journals (Sweden)

    Zigmas Zinkevičius

    2011-05-01

    Full Text Available CONCERNING SAMOGITIAN jeĩnis SummaryThe pronoun jeĩnis, -ė ʽhe, she’, noticed by V. Grinaveckis in a Samogitian dialect of Lithu­anian, is treated as an emphatic pronoun by the author of this paper. The pronoun originated on the basis of the epenthetic forms Acc. Sg. fem. jeĩnę and Instr. Sg. fem. jéine, used side by side with the regular dialect jeñję, jénje (= Standard Lith. Ją̃ją, ją́ja. The Nom. Sg. fem. jeĩnė (next to jeĩnę : jéine appeared according to the pattern kárvė : karvę : kárve; the Nom. Sg. masc. jeĩnis arose (next to jeĩnė according to the pattern medìnis : medìnė.

  10. Nursing Information System (NIS): A Tool for Qualitative Nursing ...

    African Journals Online (AJOL)

    Increasing health care cost, nurse shortages, high patient acuity and the need for more accuracy in care create the need for an effective Nursing Information System. This paper therefore highlights the relevance of NIS in enhancing professional growth and efficiency in nursing practice. It also opens up the anticipated ...

  11. Integrated NIS electron-tunnelling refrigerator/superconducting bolometer

    Energy Technology Data Exchange (ETDEWEB)

    Silverberg, R.F. [NASA/Goddard Space Flight Center, Laboratory for Experimental Cosmology, Greenbelt, MD 20771 (United States)]. E-mail: robert.silverberg@nasa.gov; Benford, D.J. [NASA/Goddard Space Flight Center, Laboratory for Experimental Cosmology, Greenbelt, MD 20771 (United States); Chen, T.C. [Global Science and Technology, Greenbelt, MD 20771 (United States); Chervenak, J. [NASA/Goddard Space Flight Center, Laboratory for Experimental Cosmology, Greenbelt, MD 20771 (United States); Finkbeiner, F. [SSAI, Greenbelt, MD 20771 (United States); Moseley, S.H. [NASA/Goddard Space Flight Center, Laboratory for Experimental Cosmology, Greenbelt, MD 20771 (United States); Duncan, W.D. [National Institute of Standards and Technology (NIST), 325 Broadway, Boulder, CO 80305 (United States); Miller, N.A. [National Institute of Standards and Technology (NIST), 325 Broadway, Boulder, CO 80305 (United States); Schmidt, D.R. [National Institute of Standards and Technology (NIST), 325 Broadway, Boulder, CO 80305 (United States); Ullom, J.N. [National Institute of Standards and Technology (NIST), 325 Broadway, Boulder, CO 80305 (United States)

    2006-04-15

    We describe progress in the development of a close-packed array of bolometers designed for use in photometric applications at millimeter wavelengths from ground-based telescopes. Each bolometer in the array will use a proximity-effect Transition Edge Sensor (TES) sensing element and each will have integrated Normal-Insulator-Superconductor (NIS) refrigerators to cool the bolometer below the thermal reservoir temperature. The NIS refrigerators and acoustic-phonon-mode-isolated bolometers are fabricated on silicon. The radiation absorbing element is mechanically suspended by four legs, whose dimensions are used to control and optimize the thermal conductance of the bolometer. Using the technology developed at NIST, we fabricate NIS refrigerators at the base of each of the suspension legs. The NIS refrigerators remove hot electrons by quantum-mechanical tunneling and are expected to cool the biased (10pW) bolometers to <170mK while the bolometers are inside a pumped {sup 3}He-cooled cryostat operating at {approx}280mK. This significantly lower temperature at the bolometer allows the detectors to approach background-limited performance despite the simple cryogenic system.

  12. Specificity and Application of the Lantibiotic Protease NisP

    Directory of Open Access Journals (Sweden)

    Manuel Montalbán-López

    2018-02-01

    Full Text Available Lantibiotics are ribosomally produced and posttranslationally modified peptides containing several lanthionine residues. They exhibit substantial antimicrobial activity against Gram-positive bacteria, including relevant pathogens. The production of the model lantibiotic nisin minimally requires the expression of the modification and export machinery. The last step during nisin maturation is the cleavage of the leader peptide. This liberates the active compound and is catalyzed by the cell wall-anchored protease NisP. Here, we report the production and purification of a soluble variant of NisP. This has enabled us to study its specificity and test its suitability for biotechnological applications. The ability of soluble NisP to cleave leaders from various substrates was tested with two sets of nisin variants. The first set was designed to investigate the influence of amino acid variations in the leader peptide or variations around the cleavage site. The second set was designed to study the influence of the lanthionine ring topology on the proteolytic efficiency. We show that the substrate promiscuity is higher than has previously been suggested. Our results demonstrate the importance of the arginine residue at the end of the leader peptide and the importance of lanthionine rings in the substrate for specific cleavage. Collectively, these data indicate that NisP is a suitable protease for the activation of diverse heterologously expressed lantibiotics, which is required to release active antimicrobial compounds.

  13. Surface-to-surface registration using level sets

    DEFF Research Database (Denmark)

    Hansen, Mads Fogtmann; Erbou, Søren G.; Vester-Christensen, Martin

    2007-01-01

    problem can be approximated by the image registration (IR) problem of the signed distance maps (SDMs) of the surfaces confined to some narrow band. By shrinking the narrow bands around the zero level sets the solution to the IR problem converges towards the S2SR problem. It is our hypothesis...... that this approach is more robust and less prone to fall into local minima than ordinary surface-to-surface registration. The IR problem is solved using the inverse compositional algorithm. In this paper, a set of 40 pelvic bones of Duroc pigs are registered to each other w.r.t. the Euclidean transformation...

  14. Methylation of sodium iodide symporter (NIS) gene in thyroid tumors

    OpenAIRE

    Ana Luiza Resende Galrão

    2011-01-01

    O iodo é transportado para a célula tireoideana através do simportador sódio-iodo (NIS). Estudo anterior de nosso grupo mostrou que a expressão do RNAm de NIS estava reduzida nos tecidos tumorais (T) tireoideanos quando comparada à dos tecidos não tumorais (NT) adjacentes. A metilação de ilhas CpG localizadas em promotores é um dos mecanismos epigenéticos que regula a expressão gênica. Já foi demonstrado que a metilação aberrante desempenha papel importante na tumorigênese humana, porém, estu...

  15. In situ preparation of NiS2/CoS2 composite electrocatalytic materials on conductive glass substrates with electronic modulation for high-performance counter electrodes of dye-sensitized solar cells

    Science.gov (United States)

    Li, Faxin; Wang, Jiali; Zheng, Li; Zhao, Yaqiang; Huang, Niu; Sun, Panpan; Fang, Liang; Wang, Lei; Sun, Xiaohua

    2018-04-01

    The electrocatalytic composite materials of honeycomb structure NiS2 nanosheets loaded with metallic CoS2 nanoparticles are in situ prepared on F doped SnO2 conductive glass (FTO) substrates used as counter electrodes of DSSCs through chemical bath deposition (CBD) and sulfidizing process. Single crystalline NiS2 honeycomb structure array lay a foundation for the large surface area of NiS2/CoS2 composite CEs. The formed NiS2/CoS2 nanointerface modulates electronic structure of composite CEs from the synergetic interactions between CoS2 nanoparticles and NiS2 nanosheets, which dramatically improves the electrocatalytic activity of NiS2/CoS2 composite CEs; Metallic CoS2 nanoparticles covering NiS2 nanosheets electrodes adjusts the electrodes' structure and then reduces the series resistance (Rs) and the Nernst diffusion resistance (Zw) of counter electrodes. The improvement of these areas greatly enhances the electrocatalytic performance of CEs and the short circuit current density (Jsc) and Fill factor (FF) of DSSCs. Impressively, the DSSC based on NiS2/CoS2-0.1 CE shows the best photovoltaic performance with photovoltaic conversion efficiency of 8.22%, which is 24.36% higher than that (6.61%) of the DSSC with Pt CE. And the NiS2/CoS2-0.1 CE also displays a good stability in the iodine based electrolyte. This work indicates that rational construction of composite electrocatalytic materials paves an avenue for high-performance counter electrodes of DSSCs.

  16. deNIS IIplus - computer-assisted crisis management system

    International Nuclear Information System (INIS)

    Corr, B.

    2007-01-01

    The management of catastrophes, as natural disasters or manmade disasters, will only be effective and successful if all relevant information is available in time for decision-makers. During previous large-scale disasters it became evident that information needed for the disaster management was only partially available and that there were fundamental deficits in regard to the flow of information between federal states (''Laender'') as well as communication problems between disaster response teams in the effected regions. On this account in summer 2001 the Federal Ministry of the Interior has decided to develop the ''German Emergency Preparedness Information System (deNIS)''. The aim of the enhanced version deNIS II plus is to built up a network for the civil and disaster response and to assist as an information and communication system for decision-makers of the Federal Government and the Laender Governments to better co-ordination relief and rescue teams in the event of a natural disaster or technical accident. Correspondingly the primary task of deNIS is to support the decision-making of disaster management authorities. (orig.)

  17. Enhanced iodide sequestration by 3-biphenyl-5,6-dihydroimidazo 2,1-b thiazole in sodium/iodide sym-porter (NIS)-expressing cells

    International Nuclear Information System (INIS)

    Lecat-Guillet, N.; Ambroise, Y.

    2008-01-01

    The ability of the sodium/iodide sym-porter (NIS) to take up iodide has long provided the basis for cyto-reductive gene therapy and cancer treatment with radio-iodide. One of the major limitations of this approach is that radio-iodide retention in NIS-expressing cells is not sufficient for their destruction. We identified and characterized a small organic molecule capable of increasing iodide retention in HEK293 cells permanently transfected with human NIS cDNA (hNIS-HEK293) and in the rat thyroid-derived cell line FRTL-5. In the presence of 3-biphenyl-4'-yl-5,6-dihydroimidazo[2,1-b)thiazole (ISA1), the transmembrane iodide concentration gradient was increased up to 4.5-fold. Our experiments indicate that the imidazo-thiazole derivative acts either by inhibiting anion efflux mechanisms, or by promoting the relocation of iodide into subcellular compartments. This new compound is not only an attractive chemical tool to investigate the mechanisms of iodide flux at the cellular level, but also opens promising perspectives in the treatment of cancer after NIS gene transfer. (authors)

  18. [Tooth macromorphological and ultrastructural analysis of osteological material from the medieval locality of St. Panteleimon Church in Nis].

    Science.gov (United States)

    Mitić, Nadica; Mitić, Aleksandar; Mitić, Vladimir; Savić, Vojin; Nikolić, Marija

    2010-01-01

    Analysis of macromorphological and ultrastructural tooth characteristics of osteological material from the medieval site of St. Pantaleimon Church in Nis provides us with insight on the life, nutrition and habits of medieval population, as well as the structure and composition of their teeth. The aim of this research, based on the tooth inspection of skeletal remains from the medieval site of St. Pantaleimon Church in Nis, was to analyze macromorphological characteristics, ultrastructure of the dental tissue of maxillary and mandibular molars, canines and incisors, as well as their chemical composition. Macromorphological and ultrastructural analysis of the dental tissue of osteological material dating from the 12th century included 1312 teeth with advanced abrasion. Macromorphological changes were detected by using a dental mirror, probe and radiography. After irrigation, the teeth were prepared using the standard procedure and analyzed by scanning electronic microscopy (JEOL-JSM-5300). Chemical analysis was done by expanded downscaling (EDS) method for Mg, P, Ca. The analysis detected second degree abrasions of all teeth in individuals aged 20-25 years. Third and fourth degree abrasions of teeth were detected in individuals aged over 40 years. Ultrastructural analysis showed a complete obliteration of dentin tubules and pulp of the lower incisors, the apposition of intratubular dentin inside the tubules, as well as extensive deformity and loss of dentin structure on molars with preserved pulp volume and nerve fiber calcification. The calcification of nerve fibers showed that the formation of intratubular dentin was proportional with the biological potential of pulp and the degree of abrasion, and inversely proportional with the size of dentin surface. Chemical analysis showed that in the analyzed teeth Ca composition was slightly lower than that in the control group, P composition was almost identical, while Mg composition was multiply increased in comparison to

  19. Sodium iodide symporter (NIS) in extrathyroidal malignancies: focus on breast and urological cancer

    International Nuclear Information System (INIS)

    Micali, Salvatore; Bulotta, Stefania; Puppin, Cinzia; Territo, Angelo; Navarra, Michele; Bianchi, Giampaolo; Damante, Giuseppe; Filetti, Sebastiano; Russo, Diego

    2014-01-01

    Expression and function of sodium iodide symporter (NIS) is requisite for efficient iodide transport in thyrocytes, and its presence in cancer cells allows the use of radioiodine as a diagnostic and therapeutic tool in thyroid neoplasia. Discovery of NIS expression in extrathyroidal tissues, including transformed cells, has opened a novel field of research regarding NIS-expressing extrathyroidal neoplasia. Indeed, expression of NIS may be used as a biomarker for diagnostic, prognostic, and therapeutic purposes. Moreover, stimulation of endogenous NIS expression may permit the radioiodine treatment of extrathyroidal lesions by concentrating this radioisotope. This review describes recent findings in NIS research in extrathyroidal malignancies, focusing on breast and urological cancer, emphasizing the most relevant developments that may have clinical impact. Given the recent progress in the study of NIS regulation as molecular basis for new therapeutic approaches in extrathyroidal cancers, particular attention is given to studies regarding the relationship between NIS and clinical-pathological aspects of the tumors and the regulation of NIS expression in the experimental models

  20. Sodium Iodide Symporter (NIS)-Mediated Radionuclide (131I, 188Re) Therapy of Liver Cancer After Transcriptionally Targeted Intratumoral in Vivo NIS Gene Delivery

    Science.gov (United States)

    Klutz, Kathrin; Willhauck, Michael J.; Wunderlich, Nathalie; Zach, Christian; Anton, Martina; Senekowitsch-Schmidtke, Reingard; Göke, Burkhard

    2011-01-01

    Abstract We reported the therapeutic efficacy of 131I in hepatocellular carcinoma (HCC) cells stably expressing the sodium iodide symporter (NIS) under the control of the tumor-specific α-fetoprotein (AFP) promoter. In the current study we investigated the efficacy of adenovirus-mediated in vivo NIS gene transfer followed by 131I and 188Re administration for the treatment of HCC xenografts. We used a replication-deficient adenovirus carrying the human NIS gene linked to the mouse AFP promoter (Ad5-AFP-NIS) for in vitro and in vivo NIS gene transfer. Functional NIS expression was confirmed by in vivo γ-camera imaging, followed by analysis of NIS protein and mRNA expression. Human HCC (HepG2) cells infected with Ad5-AFP-NIS concentrated 50% of the applied activity of 125I, which was sufficiently high for a therapeutic effect in an in vitro clonogenic assay. Four days after intratumoral injection of Ad5-AFP-NIS (3×109 plaque-forming units) HepG2 xenografts accumulated 14.5% injected dose (ID)/g 123I with an effective half-life of 13 hr (tumor-absorbed dose, 318 mGy/MBq 131I). In comparison, 9.2% ID/g 188Re was accumulated in tumors with an effective half-life of 12.8 hr (tumor-absorbed dose, 545 mGy/MBq). After adenovirus-mediated NIS gene transfer in HepG2 xenografts administration of a therapeutic dose of 131I or 188Re (55.5 MBq) resulted in a significant delay in tumor growth and improved survival without a significant difference between 188Re and 131I. In conclusion, a therapeutic effect of 131I and 188Re was demonstrated in HepG2 xenografts after tumor-specific adenovirus-mediated in vivo NIS gene transfer. PMID:21488714

  1. The sodium iodide symporter (NIS) and potential regulators in normal, benign and malignant human breast tissue.

    LENUS (Irish Health Repository)

    Ryan, James

    2011-01-01

    The presence, relevance and regulation of the Sodium Iodide Symporter (NIS) in human mammary tissue remains poorly understood. This study aimed to quantify relative expression of NIS and putative regulators in human breast tissue, with relationships observed further investigated in vitro.

  2. The iodide sym-porter (NIS): new perspectives in nuclear oncology

    International Nuclear Information System (INIS)

    Pourcher, Th.; Lindenthal, S.; Basquin, C.; Ferhat, O.; Marsault, R.; Carrier, P.; Koulibaly, M.; Bussiere, F.; Darcourt, J.

    2005-01-01

    The sodium iodide sym-porter (NIS) is the plasma membrane protein that mediates uptake of iodide in the thyroid and other organs such as the stomach and the salivary gland. The cloning of its cDNA allows the targeting of NIS expression into any cell using gene therapy. This enables iodide uptake and thus NIS can be used as reporter imaging for live animals. More intriguingly, this new technique has potential using radio-iodide therapy to selectively destroy tumour cells. These two approaches employ common techniques in nuclear medicine. Many experiments on cultured cells and on animals have been carried out; they established clearly the advantages of this genetically targeted radiotherapy. Recent studies employing this therapy on multiple myeloma cell lines implanted in mice or on hepato-carcinoma-bearing rats, resulted in important tumour remission. However, additional studies on NIS regulation and the use of alternative radioisotopes transported by NIS are required to further develop this promising approach. (author)

  3. Comparison of human sodium iodide symporter (hNIS) gene expression between lentiviral and adenoviral vectors in rat mesenchymal stem cell

    International Nuclear Information System (INIS)

    Park, So Yeon; Lee, Won Woo; Kim, Sung Jin; Lee, Heui Ran; Kim, Hyun Joo; Chung, June Key; Kim, Sang Eun

    2007-01-01

    Quantitative comparison of transgene expression within stem cells between lentivirus and adenovirus-mediated delivery systems has not been done. Here, we evaluated the human sodium iodide symporter (hNIS) gene expression in rat mesenchymal stem cell (rMSC) transduced by lentivirus or adenovirus, and compared the hNIS expression quantitatively between the two delivery systems. Lentiviral-mediated stably hNIS expressing rMSC (lenti-hNIS-rMSC) was constructed by cloning the hNIS gene into pLenti6/UbC/V5-DEST (Invitrogen) to obtain pLenti-hNIS, transducing rMSC with the pLenti-hNIS, and selecting with blasticidin for 3 weeks. Recombinant adenovirus expressing hNIS gene (Rad-hNIS) was produced by homologous recombination and Rad-hNIS transduced rMSC (adeno-hNIS-rMSC) was evaluated for the hNIS expression 48 hours post infection at MOI 1, 5, 20, 50, and 100. The hNIS expression in lenti-hNIS-rMSC or adeno-hNIS-rMSC was assessed by immunocytochemistry, western blot, and I-125 uptake. Immunocytochemistry using mono-clonal anti-hNIS antibody revealed that intensity of hNIS immunoreactivity in lenti-hNIS-rMSC was greater than that in adeno-hNIS-rMSC at MOl 20 but lower than that at MOl 50. Western blot analysis also showed that lenti-hNIS-rMSC was intermediate between adeno-hNIS-rMSCs at MOl 20 and 50 in hNIS expression. However in vitro I-125 uptake test demonstrated that iodide uptake in lenti-hNIS-rMSC (297046659 picomole/106 cells) was greater than that in adeno-hNIS-rMSC at MOI 100 (61682134 picomole/106 cells). These results suggest that lentivirus mediated hNIS expression is greater in terms of hNIS function but lower in terms of hNIS protein amount than adenovirus mediated hNIS expression 48 hours post infection. Stem cell tracking using hNIS as a reporter gene should be conducted in consideration of relative viral efficiency of transgene expression

  4. Fermi level on hydrogen terminated diamond surfaces

    Czech Academy of Sciences Publication Activity Database

    Rezek, Bohuslav; Saurer, C.; Nebel, C. E.; Stutzmann, M.; Ristein, J.; Ley, L.; Snidero, E.; Bergonzo, P.

    2003-01-01

    Roč. 82, č. 14 (2003), s. 2266-2268 ISSN 0003-6951 EU Projects: European Commission(XE) HPRN-CT-1999-00139 Grant - others:DFC(DE) NE524-2 Institutional research plan: CEZ:AV0Z1010914 Keywords : atomic force microscope(AFM) * Kelvin probe experiments * diamond surface Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 4.049, year: 2003

  5. Post-synthetic modification of tryptophan containing peptides via NIS mediation.

    Science.gov (United States)

    Gu, Chen-Xue; Bi, Qing-Wei; Gao, Chu-Kun; Wen, Jian; Zhao, Zhi-Gang; Chen, Zili

    2017-04-18

    A new efficient method was developed to provide modified tryptophan peptides through NIS (N-iodosuccinimide) mediated N 2 -selective coupling of a Trp unit with 1,2,3-triazoles, of which, the preliminary spectral properties were also studied.

  6. Kunsti rõõmus ja okkaline tee Omari küünis / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2008-01-01

    Naissaarel Omari küünis esietendus 7. juulil Nargen festivali raames Kristian Smedsi lavastus "Jumal on ilu" Oulus elanud kunstniku Vilho Lammi elust. Lavastus tugineb Paavo Rintala samanimelisele romaanile. Lavastuses osalevad peamiselt Soome Rahvusteatri näitlejad

  7. Human sodium iodide symporter (hNIS) in fibroadenoma breast--a immunohistochemical study.

    Science.gov (United States)

    Rai, Ruchi; Shrivastava, Ashutosh; Tandon, Ashwani; Godbole, Madan M; Kumar, Sandeep; Das, Vinita; Dwivedi, Varsha; Pal, Lily

    2011-02-01

    Human sodium iodide symporter (hNIS), responsible for the active transport of iodine is an integral plasma membrane glycoprotein present in the thyroid cells and extrathyroid tissues like breast and salivary glands. If its functional form is unequivocally shown in benign or malignant breast tissues, then it may serve as a basis for diagnosis and treatment using radioactive iodine. With an aim to analyze the hNIS expression in a distinct benign breast condition of fibroadenoma, biopsy proven fibroadenoma tissues, normal non-lactating breast tissue and biopsy proven infiltrating duct carcinoma tissues were examined for hNIS expression using immunohistochemistry. Out of 20 biopsy proven fibroadenoma tissues, 19 (95%) showed positivity for hNIS protein and only one was negative. Of these 10% were mildly positive, 50% cases were moderately positive and 35% showed intense positivity. None of the control tissue obtained from reduction mammoplasty specimens or normal breast tissues samples (5 cms away from the tumor) were positive, hNIS was also intensely positive in 9 out of 10 (90%) infiltrating duct carcinoma tissues and moderately positive in one case. These preliminary results show that hNIS was present in high frequency as demonstrated by immunohistochemistry in fibroadenoma breast.

  8. Recovery of NIS expression in thyroid cancer cells by overexpression of Pax8 gene

    International Nuclear Information System (INIS)

    Presta, Ivan; Filetti, Sebastiano; Russo, Diego; Arturi, Franco; Ferretti, Elisabetta; Mattei, Tiziana; Scarpelli, Daniela; Tosi, Emanuele; Scipioni, Angela; Celano, Marilena; Gulino, Alberto

    2005-01-01

    Recovery of iodide uptake in thyroid cancer cells by means of obtaining the functional expression of the sodium/iodide symporter (NIS) represents an innovative strategy for the treatment of poorly differentiated thyroid cancer. However, the NIS gene expression alone is not always sufficient to restore radioiodine concentration ability in these tumour cells. In this study, the anaplastic thyroid carcinoma ARO cells were stably transfected with a Pax8 gene expression vector. A quantitative RT-PCR was performed to assess the thyroid specific gene expression in selected clones. The presence of NIS protein was detected by Western blot and localized by immunofluorescence. A iodide uptake assay was also performed to verify the functional effect of NIS induction and differentiation switch. The clones overexpressing Pax8 showed the re-activation of several thyroid specific genes including NIS, Pendrin, Thyroglobulin, TPO and TTF1. In ARO-Pax8 clones NIS protein was also localized both in cell cytoplasm and membrane. Thus, the ability to uptake the radioiodine was partially restored, associated to a high rate of efflux. In addition, ARO cells expressing Pax8 presented a lower rate of cell growth. These finding demonstrate that induction of Pax8 expression may determine a re-differentiation of thyroid cancer cells, including a partial recovery of iodide uptake, fundamental requisite for a radioiodine-based therapeutic approach for thyroid tumours

  9. A two-step hydrothermal synthesis approach to synthesize NiCo2S4/NiS hollow nanospheres for high-performance asymmetric supercapacitors

    Science.gov (United States)

    Xu, Rui; Lin, Jianming; Wu, Jihuai; Huang, Miaoliang; Fan, Leqing; He, Xin; Wang, Yiting; Xu, Zedong

    2017-11-01

    In this work, a high-performance asymmetric supercapacitor device based on NiCo2S4/NiS hollow nanospheres as the positive electrode and the porous activated carbon as the negative electrode was successfully fabricated via a facile two-step hydrothermal synthesis approach. This NiCo2S4/NiS//activated carbon asymmetric supercapacitor achieved a high energy density of 43.7 Wh kg-1 at a power density of 160 W kg-1, an encouraging specific capacitance of 123 F g-1 at a current density of 1 mA cm-2, as well as a long-term performance with capacitance degradation of 5.2% after 3000 consecutive cycles at 1 mA cm-2. Moreover, the NiCo2S4/NiS electrode also demonstrated an excellent specific capacitance (1947.5 F g-1 at 3 mA cm-2) and an outstanding cycling stability (retaining 90.3% after 1000 cycles). The remarkable electrochemical performances may be attributed to the effect of NiS doping on NiCo2S4 which could enlarge the surface area and increase the surface roughness.

  10. Nuclear legislation in central and eastern europe and the NIS

    International Nuclear Information System (INIS)

    2003-01-01

    This study presents the current state of legislation and regulations governing the peaceful uses of nuclear energy in the central and eastern European countries (CEEC) and the New Independent States (NIS). It also contains information on the national bodies responsible for the regulation and control of nuclear energy. The nuclear energy sector has not escaped from the changes that have affected the political, economic and social climates over the past fifteen years. Under the former socialist regime, activities in this field came within the sole remit of the State administration. In the legal area, it had not been deemed necessary in most of these countries to enact laws guaranteeing democratic control of electronuclear programmes and establishing a clear distinction between activities promoting this source of energy and regulatory control, while ensuring that safety imperatives take priority over all other considerations. With the arrival of new political forces came the will to remedy this situation promptly by creating new regulatory structures and drafting legislative texts based on those used in western countries. This evolution was all the more necessary given that, at the same time, the new policy of accountability had revealed safety defects in numerous nuclear installations in these countries, thus rendering international assistance indispensable. From the legal point of view, the outcome of these years of effort is remarkably positive: almost all countries of Eastern Europe pursuing electronuclear programmes have established institutions capable of exercising efficient control over nuclear power plants and other installations. Accession to the international conventions which form the backbone of nuclear law has become widespread. Modern legislation is henceforth in place in almost all of these states. (author)

  11. What really separates us? Survey of attitudes of young people in the cities of Kikinda (Vojvodina), Nis, Bor (South and East Serbia), and Pristina, Pec, Prizren (Kosovo)

    OpenAIRE

    Bašić Goran

    2014-01-01

    The results of the survey point to a high level of agreement among youth aged between 15 and 25 years of age, high school and college students, employed and unemployed youth, men and women in the cities of Pec, Pristina, Prizren in Kosovo, and Bor, Kikinda, and Nis in Serbia, on whether the question of mutual cooperation is burdened by prejudice and events from the past, and that the possibility and the quality of cooperation is influenced by the attitudes ...

  12. Deteksi Natrium/Iodide Symporter (NIS pada Galur Sel Kanker Payudara SKBR3 dengan Imunositofluoresens

    Directory of Open Access Journals (Sweden)

    Aisyah Elliyanti

    2016-03-01

    Full Text Available SKBR-3 cell line is a breast cancer model for human epidermal growth factor receptor2 (HER2 positive. Only 50% of patients of this type have fully responded to chemotherapy. Natrium iodide symporter expression correlates with the uptake and ability of cells to accumulate radioiodine. The aim of this study was to examine natrium/iodide symporter (NIS expression and its distribution with and without epidermal growth factor (EGF treatment using immunocytofluoresence (ICF. This study was conducted at the Cell Culture Laboratory, Faculty of Medicine, Universitas Padjadjaran from September 2013 to April 2014. SKBR3 cells were cultured until 70% confluent. Cells were then divided into two groups: treatment group and control group. The treatment group was treated with EGF 50 ng/mL. Cells were incubated with primary antibody rabbit polyclonal antibody anti-NIS, and then were followed with secondary-antibody goat polyclonal antibody to rabbit. Data from the observation were then assessed semi-quantitatively. Natrium/iodide symporter was seen to be expressed and distributed in the cytoplasm. Cells induced by EGF showed significant increase in NIS expression in cytoplasm and its distribution in cell membrane. It is concluded that the SKBR3 cells express NIS in cytoplasm and that EGF induction increases NIS expression and distribution in cell membrane. This finding leads to a potential ability of breast cancer cells to uptake and accumulate radioiodine.

  13. Comparing the NIS vs. MRC and INCAT sensory scale through Rasch analyses.

    Science.gov (United States)

    Draak, Thomas H P; Vanhoutte, Els K; van Nes, Sonja I; Gorson, Kenneth C; Van der Pol, W-Ludo; Notermans, Nicolette C; Nobile-Orazio, Eduardo; Lewis, Richard A; Léger, Jean-Marc; Van den Bergh, Peter Y K; Lauria, Giuseppe; Bril, Vera; Katzberg, Hans; Lunn, Michael P T; Pouget, Jean; van der Kooi, Anneke J; Hahn, Angelika F; van den Berg, Leonard H; van Doorn, Pieter A; Cornblath, David R; Faber, Catharina G; Merkies, Ingemar S J

    2015-09-01

    We performed a comparison between Neuropathy Impairment Scale-sensory (NISs) vs. the modified Inflammatory Neuropathy Cause and Treatment sensory scale (mISS), and NIS-motor vs. the Medical Research Council sum score in patients with Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and IgM monoclonal gammopathy of undetermined significance-related polyneuropathy (MGUSP). The ordinal data were subjected to Rasch analyses, creating Rasch-transformed (RT)-intervals for all measures. Comparison between measures was based on validity/reliability with an emphasis on responsiveness (using the patient's level of change related to the individually obtained varying SE for minimum clinically important difference). Eighty stable patients (GBS: 30, CIDP: 30, and MGUSP: 20) were assessed twice (entry: two observers; 2-4 weeks later: one observer), and 137 newly diagnosed or relapsing patients (GBS: 55, CIDP: 59, and IgM-MGUSP: 23) were serially examined with 12 months follow-up. Data modifications were needed to improve model fit for all measures. The sensory and motor scales demonstrated approximately equal and acceptable validity and reliability scores. Responsiveness scores were poor but slightly higher in RT-mISS compared to RT-NISs. Responsiveness was equal for the RT-motor scales, but higher in GBS compared to CIDP; responsiveness was poor in patients with MGUSP, suggesting a longer duration of follow-up in the latter group of patients. © 2015 Peripheral Nerve Society.

  14. NiS1.97: A New Efficient Water Oxidation Catalyst for Photoelectrochemical Hydrogen Generation.

    Science.gov (United States)

    Bhosale, Reshma; Kelkar, Sarika; Parte, Golu; Fernandes, Rohan; Kothari, Dushyant; Ogale, Satishchandra

    2015-09-16

    NiS1.97, a sulfur-deficient dichalcogenide, in nanoscale form, is shown to be a unique and efficient photoelectrochemical (PEC) catalyst for H2 generation by water splitting. Phase pure NiS1.97 nanomaterial is obtained by converting nickel oxide into sulfide by controlled sulfurization method, which is otherwise difficult to establish. The defect states (sulfur vacancies) in this material increase the carrier density and in turn lead to favorable band line-up with respect to redox potential of water, rendering it to be an effective photoelectrochemical catalyst. The material exhibits a remarkable PEC performance of 1.25 mA/cm(2) vs NHE at 0.68 V in neutral pH, which is almost 1000 times superior as compared with that of the stoichiometric phase of NiS2. The latter is well-known to be a cocatalyst but not as a primary PEC catalyst.

  15. Au-controlled enhancement of photoluminescence of NiS nanostructures synthesized via a microwave-assisted hydrothermal technique

    CSIR Research Space (South Africa)

    Linganiso, EC

    2014-11-01

    Full Text Available Nickel sulphide (NiS) nanostructures decorated with gold (Au) nanoparticles (NPs) were synthesized via a microwave-assisted hydrothermal technique. Binary phase NiS (a and ß) crystalline nanostructures, bare, and decorated with Au NPs were obtained...

  16. Fabrication and characterization of multi-level hierarchical surfaces.

    Science.gov (United States)

    Bhushan, Bharat; Lee, Hyungoo

    2012-01-01

    A nanostructured surface may exhibit low adhesion or high adhesion depending upon fibrillar density, and it presents the possibility of realizing eco-friendly surface structures with desirable adhesion by mimicking the mechanics of fibrillar adhesive surfaces of biological systems. The current research uses a patterning technique to fabricate smart adhesion surfaces: one-, two- and three-level hierarchical synthetic adhesive structure surfaces with various fibrillar densities and diameters. The contact angles and contact angle hysteresis were measured to characterize the wettability. A conventional and a glass ball attached to an atomic force microscope (AFM) tip were used to obtain the adhesive forces via force-distance curves and to study the buckling behavior of a single fiber on the hierarchical structures.

  17. Direct detection of two different tumor-derived extracellular vesicles by SAM-AuNIs LSPR biosensor.

    Science.gov (United States)

    Thakur, Abhimanyu; Qiu, Guangyu; Ng, Siu-Pang; Guan, Jintao; Yue, Jianbo; Lee, Youngjin; Wu, Chi-Man Lawrence

    2017-08-15

    Extracellular vesicles (EVs) are abundant in various biological fluids including blood, saliva, urine, as well as extracellular milieu. Accumulating evidence has indicated that EVs, which contain functional proteins and small RNAs, facilitate intercellular communication between neighbouring cells, and are critical to maintain various physiological processes. In contrast, EV-derived toxic signals can spread out over the tissues adjacent to the injured area in certain diseases, including brain tumors and neurodegenerative disorders. This demands better characterization of EVs which can be employed for liquid biopsy clinically as well as for the study of intercellular signalling. Exosomes and microvesicles share a number of similar characteristics, but it is important to distinguish between these two types of EVs. Here, we report for the first time that our in-house developed Localized Surface Plasmon Resonance biosensor with self-assembly gold nanoislands (SAM-AuNIs) can be used to detect and distinguish exosomes from MVs isolated from A-549 cells, SH-SY5Y cells, blood serum, and urine from a lung cancer mouse model. Exosomes, compared with MVs, produced a distinguishable response to the bare LSPR biosensor without functionalization, suggesting a different biophysical interaction between exosomes and MVs with SAM AuNIs. This sensor attains the limit of detection to 0.194µg/ml, and the linear dynamic range covers 0.194-100µg/ml. This discovery not only reveals great insight into the distinctive membrane property of tumor-derived exosomes and MVs, but also facilitate the development of novel LSPR biosensors for direct detection and isolation of heterogeneous EVs. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. A siphon gage for monitoring surface-water levels

    Science.gov (United States)

    McCobb, T.D.; LeBlanc, D.R.; Socolow, R.S.

    1999-01-01

    A device that uses a siphon tube to establish a hydraulic connection between the bottom of an onshore standpipe and a point at the bottom of a water body was designed and tested for monitoring surface-water levels. Water is added to the standpipe to a level sufficient to drive a complete slug of water through the siphoning tube and to flush all air out of the system. The water levels in the standpipe and the water body equilibrate and provide a measurable static water surface in the standpipe. The siphon gage was designed to allow quick and accurate year-round measurements with minimal maintenance. Currently available devices for monitoring surface-water levels commonly involve time-consuming and costly installation and surveying, and the movement of reference points and the presence of ice cover in cold regions cause discontinuity and inaccuracy in the data collected. Installation and field testing of a siphon gage using 0.75-in-diameter polyethylene tubing at Ashumet Pond in Falmouth, Massachusetts, demonstrated that the siphon gage can provide long-term data with a field effort and accuracy equivalent to measurement of ground-water levels at an observation well.A device that uses a siphon tube to establish a hydraulic connection between the bottom of an onshore standpipe and a point at the bottom of a water body was designed and tested for monitoring surface-water levels. Water is added to the standpipe to a level sufficient to drive a complete slug of water through the siphoning tube and to flush all air out of the system. The water levels in the standpipe and the water body equilibrate and provide a measurable static water surface in the standpipe. The siphon gage was designed to allow quick and accurate year-round measurements with minimal maintenance. Currently available devices for monitoring surface-water levels commonly involve time-consuming and costly installation and surveying, and the movement of reference points and the presence of ice cover in cold

  19. Immobilized enzymes: understanding enzyme - surface interactions at the molecular level.

    Science.gov (United States)

    Hoarau, Marie; Badieyan, Somayesadat; Marsh, E Neil G

    2017-11-22

    Enzymes immobilized on solid supports have important and industrial and medical applications. However, their uses are limited by the significant reductions in activity and stability that often accompany the immobilization process. Here we review recent advances in our understanding of the molecular level interactions between proteins and supporting surfaces that contribute to changes in stability and activity. This understanding has been facilitated by the application of various surface-sensitive spectroscopic techniques that allow the structure and orientation of enzymes at the solid/liquid interface to be probed, often with monolayer sensitivity. An appreciation of the molecular interactions between enzyme and surface support has allowed the surface chemistry and method of enzyme attachement to be fine-tuned such that activity and stability can be greatly enhanced. These advances suggest that a much wider variety of enzymes may eventually be amenable to immobilization as green catalysts.

  20. Automatic Measurement of Low Level Contamination on Concrete Surfaces

    International Nuclear Information System (INIS)

    Tachibana, M.; Itoh, H.; Shimada, T.; Yanagihara, S.

    2002-01-01

    Automatic measurement of radioactivity is necessary for considering cost effectiveness in final radiological survey of building structures in decommissioning nuclear facilities. The RAPID (radiation measuring pilot device for surface contamination) was developed to be applied to automatic measurement of low level contamination on concrete surfaces. The RAPID has a capability to measure contamination with detection limit of 0.14 Bq/cm2 for 60Co in 30 seconds of measurement time and its efficiency is evaluated to be 5 m2/h in a normal measurement option. It was confirmed that low level contamination on concrete surfaces could be surveyed by the RAPID efficiently compared with direct measurement by workers through its actual application

  1. Origin of metallic surface core-level shifts

    DEFF Research Database (Denmark)

    Aldén, Magnus; Skriver, Hans Lomholt; Abrikosov, I. A.

    1995-01-01

    The unique property of the open 4f energy shell in the lanthanide metals is used to show that the initial-state energy shift gives an insufficient description of surface core-level shifts. Instead a treatment, which fully includes the final-state screening, account for the experimentally observed...

  2. Challenges/issues of NIS used in particle accelerator facilities

    Science.gov (United States)

    Faircloth, Dan

    2013-09-01

    High current, high duty cycle negative ion sources are an essential component of many high power particle accelerators. This talk gives an overview of the state-of-the-art sources used around the world. Volume, surface and charge exchange negative ion production processes are detailed. Cesiated magnetron and Penning surface plasma sources are discussed along with surface converter sources. Multicusp volume sources with filament and LaB6 cathodes are described before moving onto RF inductively coupled volume sources with internal and external antennas. The major challenges facing accelerator facilities are detailed. Beam current, source lifetime and reliability are the most pressing. The pros and cons of each source technology is discussed along with their development programs. The uncertainties and unknowns common to these sources are discussed. The dynamics of cesium surface coverage and the causes of source variability are still unknown. Minimizing beam emittance is essential to maximizing the transport of high current beams; space charge effects are very important. The basic physics of negative ion production is still not well understood, theoretical and experimental programs continue to improve this, but there are still many mysteries to be solved.

  3. Evaluation of hydrogen and oxygen impurity levels on silicon surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Kenny, M.J.; Wielunski, L.S.; Netterfield, R.P.; Martin, P.J.; Leistner, A. [Commonwealth Scientific and Industrial Research Organisation (CSIRO), Lindfield, NSW (Australia). Div. of Applied Physics

    1996-12-31

    This paper reports on surface analytical techniques used to quantify surface concentrations of impurities such as oxygen and hydrogen. The following analytical techniques were used: Rutherford and Backscattering, elastic recoil detection, time-of-flight SIMS, spectroscopic ellipsometry, x-ray photoelectron spectroscopy. The results have shown a spread in thickness of oxide layer, ranging from unmeasurable to 1.6 nm. The data must be considered as preliminary at this stage, but give some insight into the suitability of the techniques and a general idea of the significance of impurities at the monolayer level. These measurements have been carried out on a small number of silicon surfaces both semiconductor grade <111> crystalline material and silicon which has been used in sphere fabrication. 5 refs., 1 fig.

  4. Trace-level mercury removal from surface water

    International Nuclear Information System (INIS)

    Klasson, K.T.; Bostick, D.T.

    1998-01-01

    Many sorbents have been developed for the removal of mercury and heavy metals from waters; however, most of the data published thus far do not address the removal of mercury to the target levels represented in this project. The application to which these sorbents are targeted for use is the removal of mercury from microgram-per-liter levels to low nanogram-per-liter levels. Sorbents with thiouronium, thiol, amine, sulfur, and proprietary functional groups were selected for these studies. Mercury was successfully removed from surface water via adsorption onto Ionac SR-4 and Mersorb resins to levels below the target goal of 12 ng/L in batch studies. A thiol-based resin performed the best, indicating that over 200,000 volumes of water could be treated with one volume of resin. The cost of the resin is approximately $0.24 per 1,000 gal of water

  5. Surface drainage in leveled land: Implication of slope

    Directory of Open Access Journals (Sweden)

    Antoniony S. Winkler

    Full Text Available ABSTRACT In the lowlands of Rio Grande do Sul, land leveling is mostly carried out with no slope for the purpose of rice production. In this environment, soils with a low hydraulic conductivity are predominant owing to the presence of a practically impermeable B-horizon near the surface. Land leveling leads to soil accommodation resulting in the formation of depressions where water accumulates after heavy rainfalls, subsequently leading to problems with crops implanted in succession to rice, such as soybeans. The objective of this research was to quantify the areas and volumes of water accumulation in soil as a function of the slope of land leveling. Five typical leveled lowland areas were studied as a part of this research. The original areas presented slopes of 0, 0.20, 0.25, 0.28 and 0.40%, which were used to generate new digital elevation models with slopes between 0 and 0.5%. These newly generated digital models were used to map the depressions with surface water storage. In conclusion, land leveling with slopes higher than 0.1% is recommended to minimize problems with superficial water storage in rice fields.

  6. Sea level: measuring the bounding surfaces of the ocean.

    Science.gov (United States)

    Tamisiea, Mark E; Hughes, Chris W; Williams, Simon D P; Bingley, Richard M

    2014-09-28

    The practical need to understand sea level along the coasts, such as for safe navigation given the spatially variable tides, has resulted in tide gauge observations having the distinction of being some of the longest instrumental ocean records. Archives of these records, along with geological constraints, have allowed us to identify the century-scale rise in global sea level. Additional data sources, particularly satellite altimetry missions, have helped us to better identify the rates and causes of sea-level rise and the mechanisms leading to spatial variability in the observed rates. Analysis of all of the data reveals the need for long-term and stable observation systems to assess accurately the regional changes as well as to improve our ability to estimate future changes in sea level. While information from many scientific disciplines is needed to understand sea-level change, this review focuses on contributions from geodesy and the role of the ocean's bounding surfaces: the sea surface and the Earth's crust. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  7. Sea level: measuring the bounding surfaces of the ocean

    Science.gov (United States)

    Tamisiea, Mark E.; Hughes, Chris W.; Williams, Simon D. P.; Bingley, Richard M.

    2014-01-01

    The practical need to understand sea level along the coasts, such as for safe navigation given the spatially variable tides, has resulted in tide gauge observations having the distinction of being some of the longest instrumental ocean records. Archives of these records, along with geological constraints, have allowed us to identify the century-scale rise in global sea level. Additional data sources, particularly satellite altimetry missions, have helped us to better identify the rates and causes of sea-level rise and the mechanisms leading to spatial variability in the observed rates. Analysis of all of the data reveals the need for long-term and stable observation systems to assess accurately the regional changes as well as to improve our ability to estimate future changes in sea level. While information from many scientific disciplines is needed to understand sea-level change, this review focuses on contributions from geodesy and the role of the ocean's bounding surfaces: the sea surface and the Earth's crust. PMID:25157196

  8. MPC&A training needs of the NIS/Baltics States.

    Energy Technology Data Exchange (ETDEWEB)

    Beck, David Franklin; Stoy-McLeod, Carol L.

    2006-07-01

    This report serves to document contract deliverables considered to be of continuing interest associated with two workshops conducted as part of an initial assessment of Material Protection, Control, and Accounting (MPC&A) training needs of the Newly Independent and Baltic States (NIS/Baltics). These workshops were held in Kiev, Ukraine, ca. 2003-2004, with the assistance of personnel from the George Kuzmycz Training Center (GKTC) of the Kiev Institute of Nuclear Research (KINR). Because of the dominant role Ukraine plays in the region in terms of the nuclear industry, one workshop focused exclusively on Ukrainian training needs, with participants attending from twelve Ukrainian organizations (plus U.S. DOE/NNSA representatives). The second workshop included participation by a further ten countries from the NIS/Baltics region. In addition, the training needs data developed during the workshop were supplemented by the outcomes of surveys and studies conducted by the GKTC.

  9. SPECT Imaging for in vivo tracking of NIS containing stem cells

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Zhenghong

    2013-04-02

    Na+/I- symporter (NIS) gene as a reporter gene (imagene) for non-invasive imaging of infused stem cells distribution and persistence in vivo on small animal models. NIS is an intrinsic membrane glycoprotein that mediates active iodide (I-) uptake into normal thyroid follicular cells and other cells. The advantages of using NIS for non-invasive and repeated scintigraphic imaging in this application are: a) NIS is not a foreign gene and thus eliminate the immunoresponse problem; b) radiotracer or substrate for NIS is simply radioiodide (I-125, I- 123, I-124, and I-124) or [Tc-99m]-pertechnetate, no radiosynthesis is needed. It has been shown that NIS gene transfer can induce radioactive iodide uptake in a variety of cells and that xenografts expressing exogenous NIS could be imaged by non-invasive scintigraphic imaging. The specific aims are: 1.Determine the feasibility, stability and physiological effects of human NIS gene expression on human HSCs and MSCs in vitro. 2.Determine the engraftment of human HSC and MSC co-infused in NOD-SCID mice. 3.Transduce both a drug resistance gene and an imagene into bone marrow stem cells, and follow the dynamics of engraftment after selection in real time.

  10. Subsethood-product fuzzy neural inference system (SuPFuNIS).

    Science.gov (United States)

    Paul, S; Kumar, S

    2002-01-01

    A new subsethood-product fuzzy neural inference system (SuPFuNIS) is presented in this paper. It has the flexibility to handle both numeric and linguistic inputs simultaneously. Numeric inputs are fuzzified by input nodes which act as tunable feature fuzzifiers. Rule based knowledge is easily translated directly into a network architecture. Connections in the network are represented by Gaussian fuzzy sets. The novelty of the model lies in a combination of tunable input feature fuzzifiers; fuzzy mutual subsethood-based activation spread in the network; use of the product operator to compute the extent of firing of a rule; and a volume-defuzzification process to produce a numeric output. Supervised gradient descent is employed to train the centers and spreads of individual fuzzy connections. A subsethood-based method for rule generation from the trained network is also suggested. SuPFuNIS can be applied in a variety of application domains. The model has been tested on Mackey-Glass time series prediction, Iris data classification, Hepatitis medical diagnosis, and function approximation benchmark problems. We also use a standard truck backer-upper control problem to demonstrate how expert knowledge can be used to augment the network. The performance of SuPFuNIS compares excellently with other various existing models.

  11. Ab initio surface core-level shifts and surface segregation energies

    DEFF Research Database (Denmark)

    Aldén, Magnus; Skriver, Hans Lomholt; Johansson, Börje

    1993-01-01

    We have calculated the surface core-level energy shifts of the 4d and 5d transition metals by means of local-density theory and a Green’s-function technique based on the linear muffin-tin orbitals method. Final-state effects are included by treating the core-ionized atom as an impurity located...

  12. Matrix elements for level shifts and widths of hydrogenic levels in ion-surface interactions

    Energy Technology Data Exchange (ETDEWEB)

    Thumm, U.; Kuerpick, P.

    1996-05-01

    The authors present a derivation of basic one-electron matrix elements involved in the ion-metal surface scattering theory. Their method allows for the convenient generation of matrix elements for high principal quantum numbers of the projectile states and thus provides basic building blocks for the ab-initio description of highly charged ion-surface interactions. The matrix elements related to the energy shifts can be evaluated for an arbitrary one-dimensional potential therefore allowing the inclusion of electronic and nuclear self-image potentials. The authors extend these concepts to wave functions generated from an arbitrary one-dimensional surface potential and show applications to various surface potentials, projectile nuclear charges and hydrogenic levels.

  13. Surface core-level shifts for simple metals

    DEFF Research Database (Denmark)

    Aldén, Magnus; Skriver, Hans Lomholt; Johansson, Börje

    1994-01-01

    We have performed an ab initio study of the surface core-level binding energy shift (SCLS) for 11 of the simple metals by means of a Green’s-function technique within the tight-binding linear-muffin-tin-orbitals method. Initial- and final-state effects are included within the concept of complete....... We furthermore conclude that the unexpected negative sign of the SCLS in beryllium is predominantly an initial-state effect and is caused by the high electron density in this metal....

  14. Expression of the Na+/l- symporter (NIS is markedly decreased or absent in gastric cancer and intestinal metaplastic mucosa of Barrett esophagus

    Directory of Open Access Journals (Sweden)

    Wapnir Irene L

    2007-01-01

    Full Text Available Abstract Background The sodium/iodide symporter (NIS is a plasma membrane glycoprotein that mediates iodide (I- transport in the thyroid, lactating breast, salivary glands, and stomach. Whereas NIS expression and regulation have been extensively investigated in healthy and neoplastic thyroid and breast tissues, little is known about NIS expression and function along the healthy and diseased gastrointestinal tract. Methods Thus, we investigated NIS expression by immunohistochemical analysis in 155 gastrointestinal tissue samples and by immunoblot analysis in 17 gastric tumors from 83 patients. Results Regarding the healthy Gl tract, we observed NIS expression exclusively in the basolateral region of the gastric mucin-producing epithelial cells. In gastritis, positive NIS staining was observed in these cells both in the presence and absence of Helicobacter pylori. Significantly, NIS expression was absent in gastric cancer, independently of its histological type. Only focal faint NIS expression was detected in the direct vicinity of gastric tumors, i.e., in the histologically intact mucosa, the expression becoming gradually stronger and linear farther away from the tumor. Barrett mucosa with junctional and fundic-type columnar metaplasia displayed positive NIS staining, whereas Barrett mucosa with intestinal metaplasia was negative. NIS staining was also absent in intestinalized gastric polyps. Conclusion That NIS expression is markedly decreased or absent in case of intestinalization or malignant transformation of the gastric mucosa suggests that NIS may prove to be a significant tumor marker in the diagnosis and prognosis of gastric malignancies and also precancerous lesions such as Barrett mucosa, thus extending the medical significance of NIS beyond thyroid disease.

  15. Dynamics of gas-surface interactions atomic-level understanding of scattering processes at surfaces

    CERN Document Server

    Díez Muniño, Ricardo

    2013-01-01

    This book gives a representative survey of the state of the art of research on gas-surface interactions. It provides an overview of the current understanding of gas surface dynamics and, in particular, of the reactive and non-reactive processes of atoms and small molecules at surfaces. Leading scientists in the field, both from the theoretical and the experimental sides, write in this book about their most recent advances. Surface science grew as an interdisciplinary research area over the last decades, mostly because of new experimental technologies (ultra-high vacuum, for instance), as well as because of a novel paradigm, the ‘surface science’ approach. The book describes the second transformation which is now taking place pushed by the availability of powerful quantum-mechanical theoretical methods implemented numerically. In the book, experiment and theory progress hand in hand with an unprecedented degree of accuracy and control. The book presents how modern surface science targets the atomic-level u...

  16. Electrochemically induced transformation of NiS nanoparticles into Ni(OH)2 in KOH aqueous solution toward electrochemical capacitors

    International Nuclear Information System (INIS)

    Hou Linrui; Yuan Changzhou; Li Diankai; Yang Long; Shen Laifa; Zhang Fang; Zhang Xiaogang

    2011-01-01

    Highlights: → NiS is synthesized by means of the H 2 O/CS 2 interface under hydrothermal treatment. → NiS itself owns poor electrochemical capacitance in 2 M KOH solution. → NiS is electrochemically induced and transformed into electroactive Ni(OH) 2 . → Ni(OH) 2 is responsible for good energy storage of the NiS in the KOH solution. → The new formed Ni(OH) 2 delivers large energy density at high rates. - Abstract: Nickel sulfide nanoparticles (NPs) are first synthesized by virtue of a unique H 2 O/CS 2 interface under mild hydrothermal treatment. Electrochemical data reveals that the as-synthesized NiS NPs themselves own poor supercapacitive behavior at initial cyclic voltammetry (CV) cycles in 2 M KOH solution, while a specific capacitance of 893 F g -1 can be surprisingly obtained at a current density of 5 A g -1 just after continuous 320 CV cycles. X-ray diffraction and Fourier transform infrared techniques demonstrate that what is really responsible for the good electrochemical capacitance in the KOH aqueous solution is the new electrochemically formed Ni(OH) 2 phase, rather than NiS NPs themselves. The Ni(OH) 2 is slowly formed during the continuous CV cycling process, in which the electrochemically induced phase transformation from NiS to Ni(OH) 2 phase takes place. Furthermore, the new Ni(OH) 2 phase demonstrates the great ability of delivering large specific capacitance at high rates.

  17. Enhanced visible-light H2 evolution of g-C3N4 photocatalysts via the synergetic effect of amorphous NiS and cheap metal-free carbon black nanoparticles as co-catalysts

    Science.gov (United States)

    Wen, Jiuqing; Li, Xin; Li, Haiqiong; Ma, Song; He, Kelin; Xu, Yuehua; Fang, Yueping; Liu, Wei; Gao, Qiongzhi

    2015-12-01

    In this report, g-C3N4-based photocatalysts with dual co-catalysts of amorphous NiS and carbon black were firstly synthesized through a facile two-step process. The g-C3N4/carbon black/NiS composite photocatalyst were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), ultraviolet-visible spectroscopy (UV-vis), N2 adsorption, photoluminescence (PL) spectra and transient photocurrent responses. The photocatalytic activities for photocatalytic hydrogen evolution under visible light irradiation (λ ≥ 420 nm) were measured using an aqueous solution containing triethanolamine as an electron donor. Moreover, the results showed that the ternary g-C3N4 photocatalyst loaded by 0.5 wt% carbon black and 1.5 wt% NiS could achieve the highest H2-production rate of 992 μmol g-1 h-1 under visible-light irradiation (>420 nm), which is about 2.51 times higher than that of the corresponding binary g-C3N4/1.5% NiS photocatalyst. It is believed that the enhanced photocatalytic H2-evolution activities could be attributed to the excellent synergetic effect between the carbon black and NiS as co-catalysts on the surface of g-C3N4, leading to the improved visible light absorption, promoted charge separation and enhanced the following H2-evolution kinetics. This work would not only demonstrate the promising potentials of carbon black as co-catalyst for applications in visible-light H2 generation, but also offer a new insight into the construction of highly efficient and stable g-C3N4-based hybrid semiconductor nanocomposites with dual co-catalysts for diverse photocatalytic applications.

  18. Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: a role in NIS expression regulation?

    Directory of Open Access Journals (Sweden)

    Schlumberger Martin

    2002-12-01

    Full Text Available Abstract Background Sodium/iodide symporter (NIS is a key protein in iodide transport by thyroid cells and this activity is a prerequisite for effective radioiodide treatment of thyroid cancer. In the majority of thyroid cancers, however, iodide uptake is reduced, probably as a result of decreased NIS protein expression. Methods To identify the mechanisms that negatively affect NIS expression in thyroid tumors, we performed electrophoresis mobility shift assays and immunoblot analysis of nuclear protein extracts from normal and tumoral thyroid tissues from 14 unrelated patients. Results Two proteins closely related to the transcription factors AP2 and Sp1 were identified in the nuclear extracts. Expression of both AP2 and Sp1 in nuclear extracts from thyroid tumors was significantly higher than that observed in corresponding normal tissues. Conclusion These observations raise the possibility that NIS expression, and subsequently iodide transport, are reduced in thyroid tumors at least in part owing to alterations in the binding activity of AP2 and Sp1 transcription factors to NIS promoter.

  19. Reduced graphene oxide-induced recrystallization of NiS nanorods to nanosheets and the improved Na-storage properties.

    Science.gov (United States)

    Pan, Qin; Xie, Jian; Zhu, Tiejun; Cao, Gaoshao; Zhao, Xinbing; Zhang, Shichao

    2014-04-07

    Preparation of two-dimensional (2D) graphene-like materials is currently an emerging field in materials science since the discovery of single-atom-thick graphene prepared by mechanical cleavage. In this work, we proposed a new method to prepare 2D NiS, where reduced graphene oxide (rGO) was found to induce the recrystallization of NiS from nanorods to nanosheets in a hydrothermal process. The process and mechanism of recrystallization have been clarified by various characterization techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS) mapping, and X-ray photoelectron spectroscopy (XPS). The characterization of ex situ NiS/rGO products by SEM and EDS mapping indicates that the recrystallization of NiS from nanorods to nanosheets is realized actually through an exfoliation process, while the characterization of in situ NiS/rGO products by SEM, TEM, and EDS mapping reveals the exfoliation process. The XPS result demonstrates that hydrothermally assisted chemical bonding occurs between NiS and rGO, which induces the exfoliation of NiS nanorods into nanosheets. The obtained NiS/rGO composite shows promising Na-storage properties.

  20. Underwater and surface strategies of 200 m world level swimmers.

    Science.gov (United States)

    Veiga, Santiago; Roig, Andreu

    2016-01-01

    Pacing strategies of elite swimmers have been consistently characterised from the average lap velocities. In the present study, we examined the racing strategies of 200 m world class-level swimmers with regard to their underwater and surface lap components. The finals and semi-finals of the 200 m races at the 2013 World Swimming Championships (Barcelona, Spain) were analysed by an innovative image-processing system (InThePool® 2.0). Free swimming velocities of elite swimmers typically decreased throughout the 200 m race laps (-0.12 m · s(-1), 95% CI -0.11 to -0.14 m · s(-1), P = 0.001, η(2) = 0.81), whereas underwater velocities, which were faster than free swimming, were not meaningfully affected by the race progress (0.02 m · s(-1), -0.01 to 0.04 m · s(-1), P = 0.01, η(2) = 0.04). When swimming underwater, elite swimmers typically travelled less distance (-0.66 m, -0.83 to -0.49 m, P = 0.001, η(2) = 0.34) from the first to the third turn of the race, although underwater distances were maintained on the backstroke and butterfly races. These strategies allowed swimmers to maintain their average velocity in the last lap despite a decrease in the free swimming velocity. Elite coaches and swimmers are advised to model their racing strategies by considering both underwater and surface race components.

  1. Materijalna motivacija kao nosilac uspešne reorganizacije kompanije NIS (Material Motivation as the Holder of a Successful Reorganization on the Example of Company Nis

    Directory of Open Access Journals (Sweden)

    Radmila Stojanović

    2015-04-01

    Full Text Available For successful organization people are the primary development resource. Motivation and satisfaction of employees become the basis of modern organizations. Motivated employees today represent a strategic resource which gain a competitive advantage for the organization. If someone wants to motivate others, must first be able to motivate yourself. That means that if in organization exists motivated staff, there must be a motivated manager who will be able to launch employees. The aim of this paper is to emphasizes the importance of material motivation for successful business of a large company that had in the past significant organizational change. Through unstructured interviews were collected data on which was investigated the hypothesis that the material motivation of the most important holder for successful reorganization on the example of leading Serbian company for exploration, production and refining of oil and gas NIS. From the above it can be concluded that high-quality human resources management involves proper motivation system, that has been based on material incentives. In this paper, attention will be focused on monetary motivation and how a well-established system of material incentives can lead to the great success of the company that had a significant reorganization in the past. It will be shown in detail the system of material incentives and the positive results which obtained by this system, when it comes to the business of the company, which today is the most desirable employer in Serbia and the region. The paper should emphasize the benefits of a fair system of motivation which brings to an organization, but also to encourage further thinking to improve this aspect of motivation, which is a prerequisite for successful business and the basis for all other activities in the HRM. The analysis results indeed show that a system of material incentives in NIS is the holder of a successful reorganization, and the proof is the business

  2. Direct evidence of spin frustration in the fcc antiferromagnet NiS sub 2

    CERN Document Server

    Matsuura, M; Endoh, Y; Hirota, K; Yamada, K

    2002-01-01

    NiS sub 2 is a well-known Mott insulator with anomalous antiferromagnetic long-range order of coexistent type I (Q sub M =(1,0,0), T sub N sub 1 =40 K) and type II (Q sub M =(1/2,1/2,1/2), T sub N sub 2 =30 K). Extensive neutron-scattering measurements reveal that magnetism in NiS sub 2 is governed by geometrical spin frustration, resulting in magnetic diffuse scattering extending along the fcc zone boundary. Although the diffuse scattering exists at temperatures as high as 250 K (6T sub N sub 1), it disappears rapidly below T sub N sub 2 , associated with minor crystal distortion. We observed a clear energy gap in addition to the low-energy spin-wave excitation at significantly below 30 K, and obtain evidence that degeneracy due to the coexistence of the two types of antiferromagnetism is relieved in the ground state via the reduction in symmetry due to distortion. (orig.)

  3. Surface encapsulation process for managing low-level radioactive wastes

    International Nuclear Information System (INIS)

    Unger, S.L.; Telles, R.W.

    1986-01-01

    Current processes for low-level radioactive waste (LLRW) stabilization involve mixing contaminants with a fixative such as cement, asphalt, polyethylene, or vinyl monomers, and subsequently curing the mixtures in containers. These methods give rise to processing difficulties and yield products lacking performance to assure long-term LLRW immobilization. Mixing of LLRW into fixatives is impeded by viscous media and the curing reaction is inhibited by LLRW constituents. Product performance is affected by corrosion of the containers which ultimately expose the cured mixtures to environmental stresses. This process, termed the ''Surface Encapsulation Process,'' circumvents these problems. A thermosetting fixative is employed that mixes readily with LLRW and is highly insensitive to inhibition in curing. The agglomerated mixtures are further stabilized by encapsulation with seamless jackets of corrosion resistant plastic, such as polyethylene. In laboratory-scale investigations, feasibility of the technique was demonstrated for managing a broad spectrum of LLRW simulants including ion-exchange resins, beads, and glasses, and sodium salts. Products tested to date meet all relevant NRC and DOT regulations governing waste fixation. The high waste loadings of the products, use of commodity resins, and processing simplicity indicated our process would provide high performance LLRW stabilization at costs that are competitive to those for processes employing state-of-the-art fixatives. An economic analysis based on managing LLRW generated by commercial power plants (≅1,000 MeW) substantiates the competitive process costs advantages

  4. Experimental study on source efficiencies for estimating surface contamination level

    International Nuclear Information System (INIS)

    Ichiji, Takeshi; Ogino, Haruyuki

    2008-01-01

    Source efficiency was measured experimentally for various materials, such as metals, nonmetals, flooring materials, sheet materials and other materials, contaminated by alpha and beta emitter radioactive nuclides. Five nuclides, 147 Pm, 60 Co, 137 Cs, 204 Tl and 90 Sr- 90 Y, were used as the beta emitters, and one nuclide 241 Am was used as the alpha emitter. The test samples were prepared by placing drops of the radioactive standardized solutions uniformly on the various materials using an automatic quantitative dispenser system from Musashi Engineering, Inc. After placing drops of the radioactive standardized solutions, the test materials were allowed to dry for more than 12 hours in a draft chamber with a hood. The radioactivity of each test material was about 30 Bq. Beta rays or alpha rays from the test materials were measured with a 2-pi gas flow proportional counter from Aloka Co., Ltd. The source efficiencies of the metals, nonmetals and sheet materials were higher than 0.5 in the case of contamination by the 137 Cs, 204 Tl and 90 Sr- 90 Y radioactive standardized solutions, higher than 0.4 in the case of contamination by the 60 Co radioactive standardized solution, and higher than 0.25 in the case of contamination by the alpha emitter the 241 Am radioactive standardized solution. These values were higher than those given in Japanese Industrial Standards (JIS) documents. In contrast, the source efficiencies of some permeable materials were lower than those given in JIS documents, because source efficiency varies depending on whether the materials or radioactive sources are wet or dry. This study provides basic data on source efficiency, which is useful for estimating the surface contamination level of materials. (author)

  5. Ethylene oligomerization using nickel dithiolene complexes Ni(S2C2R2)2 (R=Ph, CF3) and the crystal structure of Ni[S2C2(CF3)2]2.

    Science.gov (United States)

    Wang, Kun; Patil, Abhimanyu O; Zushma, Stephen; McConnachie, Jonathan M

    2007-11-01

    Nickel bis(dithiolene) complexes have been known for over four decades, yet little is known regarding the chemistry of this important subclass of inorganic coordination complexes in olefin oligomerization or polymerization. We report here that Ni(S(2)C(2)R(2))(2) (R=Ph, CF(3)) are converted to active catalysts for ethylene oligomerization when activated with methylaluminoxane (MAO). The catalyst activity is comparable to some nickel coordination complexes with N-donor ligands under similar conditions. The products are mainly butenes and hexenes, with small amounts of higher oligomers. The product distribution pattern is consistent with a nickel hydride species being the active center, where fast beta-hydride elimination limits the products to mostly butenes and hexenes. The exact nature of the active center and the reaction mechanism remain to be investigated. In addition, we determined the crystal structure for Ni[S(2)C(2)(CF(3))(2)](2). The molecule crystallizes in the P2(1)/n space group and adopts a planar geometry with expected bond lengths and angles. Comparing this structure with that for the donor-acceptor complex with perylene reveals elongation of both the Ni-S and the S-C bonds in the latter, suggesting reduction of Ni[S(2)C(2)(CF(3))(2)](2) may have occurred in the latter.

  6. ¿Quiénes son los NiNis en México?

    OpenAIRE

    Eva O. Arceo Gómez; Raymundo M. Campos Vázquez

    2011-01-01

    El objetivo del presente trabajo es caracterizar a la población entre las edades de 15 a 29 años de edad en México que no estudia y no trabaja (NiNi). Utilizamos los Censos de Población de 1990, 2000 y 2010, la ENIGH para el periodo 1992‐2010 y la ENOE para el periodo 2005‐2010. Encontramos que la proporción de NiNis en la población ha disminuido para el periodo 1990‐2010 utilizando tanto el Censo como la ENIGH. Sin embargo, existen diferencias notables por sexo y para los últimos 10 años. Co...

  7. [Stradiņš, Jānis. Zinātnes un augstskolu sākonte Latvija] / Raimo Pullat

    Index Scriptorium Estoniae

    Pullat, Raimo, 1935-

    2011-01-01

    Arvustus:Stradiņš, Jānis. Zinātnes un augstskolu sākonte Latvija. (Rīga, 2009). J. Stradiņši monograafia on ulatuslik ja sisukas kokkuvõte Läti kultuuri ja teaduse ajaloost kuni 19. sajandi lõppkümnenditeni

  8. Treatment with rhenium-188-perrhenate and iodine-131 of NIS-expressing mammary cancer in a mouse model remarkably inhibited tumor growth

    International Nuclear Information System (INIS)

    Dadachova, Ekaterina; Nguyen, Andrew; Lin, Elaine Y.; Gnatovskiy, Leo; Lu, Ping; Pollard, Jeffrey W.

    2005-01-01

    Introduction: Novel therapeutic modalities are needed for breast cancer patients in whom standard treatments are not effective. Mammary gland sodium/iodide symporter has been identified as a molecular target in breast cancers in humans and in some transgenic mouse models. We report the results of a therapy study with 131 I - and 188 ReO 4 - of breast cancer in polyoma middle T oncoprotein (PyMT) transgenic mice endogenously expressing the Na + /I - symporter (NIS). Methods: PyMT mice (12-13 weeks old) with one palpable tumor of 0.5-0.8 cm in diameter were used. For the therapy studies, PyMT mice were (1) treated with two intraperitoneal injections of 1.5 mCi of 188 ReO 4 - 1 week apart, (2) pretreated for 1 week with 5 μg of triiodothyronine (T3) followed by two intraperitoneal injections of 1.5 mCi of 131 I - 1 week apart or (3) left untreated. The tumor and normal organ uptakes were assessed by scintigraphic imaging. The thyroid function of treated and control animals was evaluated at the completion of the study by measuring the T3/thyroxine (T4) ratio in their blood. Results: There was significant uptake of 131 I - and 188 ReO 4 - in the primary palpable tumors as well as in nonpalpable tumors, stomachs and thyroids. The tumor uptake after the second injection was 10 times lower in comparison with the first injection. Tumor growth was significantly inhibited in both the 131 I - and 188 ReO 4 - groups in comparison with the control group, and tumors in the 188 ReO 4 - group increased in size significantly less than in the 131 I - group. The T3/T4 ratios were calculated to be 27 and 25 for the control group and the 188 ReO 4 - group, respectively; for 131 I - , both the T3 and T4 levels were below detection limit, demonstrating much less effect on the thyroids of treatment with 188 ReO 4 - than with 131 I - . Conclusions: These results prove that NIS expression in breast tumors in animal models allows specific, efficient and safe treatment with a variety of

  9. Evaluation of the levels of phthalate ester plasticizers in surface ...

    African Journals Online (AJOL)

    The objective of this study was to determine the level of phthalate ester plasticizers in Ethiope River water samples. Gas chromatography (GC) coupled with mass spectrometer (MS) was used to evaluate the levels of dimethyl phthalate (DMP), diethyl phthalate (DEP), dibuthyl phthalate (DBP), diethylhexyl phthalate (DEHP), ...

  10. CHEMICAL REACTIONS ON ADSORBING SURFACE: KINETIC LEVEL OF DESCRIPTION

    Directory of Open Access Journals (Sweden)

    P.P.Kostrobii

    2003-01-01

    Full Text Available Based on the effective Hubbard model we suggest a statistical description of reaction-diffusion processes for bimolecular chemical reactions of gas particles adsorbed on the metallic surface. The system of transport equations for description of particles diffusion as well as reactions is obtained. We carry out the analysis of the contributions of all physical processes to the formation of diffusion coefficients and chemical reactions constants.

  11. GHRSST Level 4 ODYSSEA Mediterranean Sea Regional Foundation Sea Surface Temperature Analysis (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily on an operational basis at Ifremer/CERSAT...

  12. GHRSST Level 4 G1SST Global Foundation Sea Surface Temperature Analysis (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily on an operational basis by the JPL OurOcean...

  13. GHRSST Level 4 RAMSSA Australian Regional Foundation Sea Surface Temperature Analysis (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily on an operational basis at the Australian Bureau...

  14. GHRSST Level 4 GAMSSA Global Foundation Sea Surface Temperature Analysis (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily on an operational basis at the Australian Bureau...

  15. GHRSST Level 4 AVHRR_AMSR_OI Global Blended Sea Surface Temperature Analysis (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) global Level 4 sea surface temperature analysis produced daily on a 0.25 degree grid at the NOAA...

  16. GHRSST Level 4 EUR Mediterranean Sea Regional Foundation Sea Surface Temperature Analysis (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily by Ifremer/CERSAT (France) using optimal...

  17. GHRSST Level 4 OSPO Global Nighttime Foundation Sea Surface Temperature Analysis (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily on an operational basis at the Office of...

  18. GHRSST Level 4 MUR North America Regional Foundation Sea Surface Temperature Analysis (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced as a retrospective dataset at the JPL Physical...

  19. GHRSST Level 4 ODYSSEA Global Foundation Sea Surface Temperature Analysis (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily on an operational basis at Ifremer/CERSAT...

  20. GHRSST Level 4 K10_SST Global 1 meter Sea Surface Temperature Analysis (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily on an operational basis at the Naval...

  1. GHRSST Level 4 OSTIA Global Foundation Sea Surface Temperature Analysis (GDS versions 1 and 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily on an operational basis at the UK Met Office...

  2. GHRSST Level 4 OSPO Global Foundation Sea Surface Temperature Analysis (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily on an operational basis at the Office of...

  3. GHRSST Level 4 DMI_OI Global Foundation Sea Surface Temperature Analysis (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily on an operational basis by the Danish...

  4. GHRSST Level 4 ODYSSEA Eastern Central Pacific Regional Foundation Sea Surface Temperature Analysis (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily on an operational basis at Ifremer/CERSAT...

  5. GHRSST Level 4 MW_OI Global Foundation Sea Surface Temperature analysis (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) global Level 4 sea surface temperature analysis produced daily on a 0.25 degree grid at Remote Sensing...

  6. Radioactivity levels in surface water of lakes around Izmir / Turkey

    International Nuclear Information System (INIS)

    Doyurum, S.; Turkozu, D. A.; Aslani, M. A. A.; Aytas, S.; Eral, M.; Kaygun, A. K.

    2006-01-01

    Radioactivity presents in surface continental waters is mainly due to the presence of radioactive elements in the earth's crust, other artificial radionuclides have appeared due to such human activities as nuclear power plants, nuclear weapons testing and manufacture and use of radioactive sources It is well known that natural radionuclides can be effective as tracers for the different processes controlling the distribution of elements among dissolved and particulate phases in aquatic systems. The detection of high radionuclide concentrations was proposed as a public health problem in several areas and consequently studies into the risks of radionuclides were started in the 2000s. Especially, these radioactive substances in groundwater are an unwanted and involuntary risk factor from natural sources, not artificial sources. These radioactive substances include uranium, radon found in uranium series, and other radioactive substances such as radium and gross alpha. Uranium present in rock, soil, and natural materials, and is found in small quantities in air, water, and food that people always contact. In this project, lake water samples were collected from three lakes around Izmir-Turkey. In surface lake water samples, pH, mV and conductivity values were measured and alkaline content was determined titrimetrically. The uranium concentrations in the lake water samples were measured using uranium analyzer. The radioactivity concentrations related to gross radium isotopes, gross-? and gross-? activities in the surface lake water were determined. The correlation among some parameters for water samples and concentrations of uranium, activity concentration of gross radium isotopes, gross alpha and gross beta radioactivity are also discussed

  7. Evaluation of the Levels of phthalate Ester Plasticizers in Surface ...

    African Journals Online (AJOL)

    ADOWIE PERE

    Department of Environmental Management and Toxicology,. College of Science, Federal University of Petroleum ... Gas chromatography (GC) coupled with mass spectrometer (MS) was used to evaluate the levels of ... benefits required for the many applications such as tubing and hose products,personal care products,.

  8. Laser surface processing with controlled nitrogen-argon concentration levels for regulated surface life time

    Science.gov (United States)

    Obeidi, M. Ahmed; McCarthy, E.; Brabazon, D.

    2018-03-01

    Laser surface modification can be used to enhance the mechanical properties of a material, such as hardness, toughness, fatigue strength, and corrosion resistance. Surface nitriding is a widely used thermochemical method of surface modification, in which nitrogen is introduced into a metal or other material at an elevated temperature within a furnace. It is used on parts where there is a need for increased wear resistance, corrosion resistance, fatigue life, and hardness. Laser nitriding is a novel method of nitriding where the surface is heated locally by a laser, either in an atmosphere of nitrogen or with a jet of nitrogen delivered to the laser heated site. It combines the benefits of laser modification with those of nitriding. Recent work on high toughness tool steel samples has shown promising results due to the increased nitrogen gas impingement onto the laser heated region. Increased surface activity and nitrogen adsorption was achieved which resulted in a deeper and harder surface compared to conventional hardening methods. In this work, the effects of the laser power, pulse repetition frequency, and overlap percentage on laser surface treatment of 316 L SST steel samples with an argon-nitrogen jet will be presented. Resulting microstructure, phase type, microhardness, and wear resistance are presented.

  9. Monitoring sea level and sea surface temperature trends from ERS satellites

    DEFF Research Database (Denmark)

    Andersen, Ole Baltazar; Knudsen, Per; Beckley, B.

    2002-01-01

    Data from the two ESA satellites ERS-1 and ERS-2 are used in global and regional analysis of sea level and sea surface temperature trends over the last, 7.8 years. T he ERS satellites and in the future the ENVISAT satellite provide unique opportunity for monitoring both changes in sea level and sea...... surface temperature as these satellites are equipped with an altimeter to measure sea level height as well as an along track scanning radiometer (ATSR) to measure the sea surface temperature. Consistent increase in both sea level and sea surface temperatures are found in most parts of the Atlantic Ocean...

  10. LRAD surface monitoring results at TA-21

    International Nuclear Information System (INIS)

    Bounds, J.A.

    1995-01-01

    In August/September 1994, NIS-6 personnel used LRAD soil surface monitor technology to characterize the extent of alpha contamination on the surface of a parking lot adjacent to TA-21, LANL, known as Material Disposal Area B. This report documents that monitoring. Based on this survey, there is no reason for concern about significant contamination in the parking area as a whole, although unexpected small hot spots could exist between the grid points where monitoring was performed. However, the grouping of high readings on the east side of the parking area does point to possible contamination at the level of 100 dpm/100 cm 2 or less (above background). Further monitoring or remediation of this area seems appropriate. In addition, because this was an alpha survey, one cannot rule out contamination under the asphalt or possibly between layers if it was paved more than once

  11. Cancer du pénis: A propos de 6 cas avec Revue de la littérature

    Directory of Open Access Journals (Sweden)

    A. Nouri

    2012-03-01

    Conclusion: Le cancer du pénis semble rare au Maroc si l'on se réfère au faible nombre pris en charge au sein de notre CHU. Son pronostic carcinologique et fonctionnel (sexuel et urinaire dépend de la précocité de la prise en charge. La chirurgie d'exérèse avec curage ganglionnaire reste le traitement de référence.

  12. Mammals of the World: MaNIS as an example of data integration in a distributed network environment

    Directory of Open Access Journals (Sweden)

    Barbara R Stein

    2004-01-01

    Full Text Available Natural history collections are the authoritative source of knowledge about the identity, evolutionary relationships, and attributes of species with which we share this planet. As such, collections of research specimens play a central and critical role in the conservation and sustainable use of biodiversity. The potential contribution of specimen data to systematic, genomic, and ecological analyses is enormous, and will be orders of magnitude greater when information is made easily accessible via distributed networks compared with stand-alone database systems in use up to the present. The Mammal Networked Information System (MaNIS is a distributed database network that permits participating institutions to provide web-based global access to their collections data for research, education and informed decision-making. The simplicity of the network’s design ensures that any institution wishing to join MaNIS may do so at relatively little cost and with relatively little technical expertise. Although development of MaNIS and its underlying architecture relied on a number of key programming tasks and innovations, much of what the project can offer at this pivotal juncture is insight into its approach and a template by which other disciplines can engage in a similar process with equal success.

  13. A surface defects inspection method based on multidirectional gray-level fluctuation

    Directory of Open Access Journals (Sweden)

    Yunpeng Ma

    2017-05-01

    Full Text Available Machine vision inspection technology provides an efficient tool for surface defects inspection. However, because of the multiformity of surface defects, the existing machine vision methods for surface defects inspection are limited by application scenarios. In order to improve the versatility of algorithms, and to process various kinds of images more accurately, we propose a new adaptive method for surface defect detection, named neighborhood gray-level difference method using the multidirectional gray-level fluctuation. This method changes thresholds and step values by extracting gray-level-fluctuating condition of images, and then it uses the neighborhood gray-level difference to segment defects from background. Experimental results demonstrate the effectiveness of the proposed method for inspecting different surface defects. Compared with other methods, the proposed method can be applied to inspect various surface defects, and it can provide more accurate defect segmentation results.

  14. Sea level and turbidity controls on mangrove soil surface elevation change

    Science.gov (United States)

    Lovelock, Catherine E.; Fernanda Adame, Maria; Bennion, Vicki; Hayes, Matthew; Reef, Ruth; Santini, Nadia; Cahoon, Donald R.

    2015-01-01

    Increases in sea level are a threat to seaward fringing mangrove forests if levels of inundation exceed the physiological tolerance of the trees; however, tidal wetlands can keep pace with sea level rise if soil surface elevations can increase at the same pace as sea level rise. Sediment accretion on the soil surface and belowground production of roots are proposed to increase with increasing sea level, enabling intertidal habitats to maintain their position relative to mean sea level, but there are few tests of these predictions in mangrove forests. Here we used variation in sea level and the availability of sediments caused by seasonal and inter-annual variation in the intensity of La Nina-El Nino to assess the effects of increasing sea level on surface elevation gains and contributing processes (accretion on the surface, subsidence and root growth) in mangrove forests. We found that soil surface elevation increased with mean sea level (which varied over 250 mm during the study) and with turbidity at sites where fine sediment in the water column is abundant. In contrast, where sediments were sandy, rates of surface elevation gain were high, but not significantly related to variation in turbidity, and were likely to be influenced by other factors that deliver sand to the mangrove forest. Root growth was not linked to soil surface elevation gains, although it was associated with reduced shallow subsidence, and therefore may contribute to the capacity of mangroves to keep pace with sea level rise. Our results indicate both surface (sedimentation) and subsurface (root growth) processes can influence mangrove capacity to keep pace with sea level rise within the same geographic location, and that current models of tidal marsh responses to sea level rise capture the major feature of the response of mangroves where fine, but not coarse, sediments are abundant.

  15. Sea level and turbidity controls on mangrove soil surface elevation change

    Science.gov (United States)

    Lovelock, Catherine E.; Adame, Maria Fernanda; Bennion, Vicki; Hayes, Matthew; Reef, Ruth; Santini, Nadia; Cahoon, Donald R.

    2015-02-01

    Increases in sea level are a threat to seaward fringing mangrove forests if levels of inundation exceed the physiological tolerance of the trees; however, tidal wetlands can keep pace with sea level rise if soil surface elevations can increase at the same pace as sea level rise. Sediment accretion on the soil surface and belowground production of roots are proposed to increase with increasing sea level, enabling intertidal habitats to maintain their position relative to mean sea level, but there are few tests of these predictions in mangrove forests. Here we used variation in sea level and the availability of sediments caused by seasonal and inter-annual variation in the intensity of La Nina-El Nino to assess the effects of increasing sea level on surface elevation gains and contributing processes (accretion on the surface, subsidence and root growth) in mangrove forests. We found that soil surface elevation increased with mean sea level (which varied over 250 mm during the study) and with turbidity at sites where fine sediment in the water column is abundant. In contrast, where sediments were sandy, rates of surface elevation gain were high, but not significantly related to variation in turbidity, and were likely to be influenced by other factors that deliver sand to the mangrove forest. Root growth was not linked to soil surface elevation gains, although it was associated with reduced shallow subsidence, and therefore may contribute to the capacity of mangroves to keep pace with sea level rise. Our results indicate both surface (sedimentation) and subsurface (root growth) processes can influence mangrove capacity to keep pace with sea level rise within the same geographic location, and that current models of tidal marsh responses to sea level rise capture the major feature of the response of mangroves where fine, but not coarse, sediments are abundant.

  16. Assessment of surface contamination level in an operating uranium ore processing facility of Jaduguda, India

    International Nuclear Information System (INIS)

    Meena, J.S.; Patnaik, R.L.; Jha, V.N.; Sahoo, S.K.; Ravi, P.M.; Tripathi, R.M.

    2014-01-01

    Radiological concern of the occupational workers and the area is given priority over other safety issue in confirmation with the stipulated guideline of national regulatory agency (AERB/FEFCF/SG-2, 2007). The key concern from the radiological hazard evaluation point of view is air activity, external gamma level and surface contamination. Present investigations was carried out to ascertain the surface contamination level of uranium ore processing facility at Jaduguda, Jharkhand. For a low grade uranium ore processing industry surface contamination is a major concern in product precipitation and recovery section. In view of this, the ore processing plant can broadly be classified into three areas i.e. ion exchange area, precipitation and product recovery section and other areas. The monitoring results incorporate the level of surface contamination of the plant during the last five years. The geometric mean activity of surface contamination level was 31.1, 34.5 and 9.8 Bq dm -2 in ion exchange, product precipitation and recovery and other areas with GSD of 2, 2.5 and 1.9. In most of the cases the surface contamination level was well within the recommended limit of 100 Bq dm -2 for M class uranium compound. Occasional cases of surface contamination levels exceeding the recommended limit were addressed and areas were decontaminated. Based on the study, modification in the design feature of the surface of the finished product section was also suggested so that the decontamination procedure can be more effectively implemented

  17. Heavy metals levels in surface waters and sediments in an oilfield in ...

    African Journals Online (AJOL)

    Heavy metal levels in the surface waters and sediments from five sampling stations of the Bukuma oilfield, in the Niger Delta, Nigeria were investigated using the AAS technique after standard procedures of storage and extraction. Mean range (mg/l) in the surface waters varied from Zn (0.19 0.64); Pb (ND 0.60); Cd (ND ...

  18. Electron mobility on the surface of liquid Helium: influence of surface level atoms and depopulation of lowest subbands

    International Nuclear Information System (INIS)

    Grigoriev, P. D.; Dyugaev, A. M.; Lebedeva, E. V.

    2008-01-01

    The temperature dependence of electron mobility is examined. We calculate the contribution to the electron scattering rate from the surface level atoms (SLAs), proposed in [10]. This contribution is substantial at low temperatures T < 0.5, when the He vapor concentration is exponentially small. We also study the effect of depopulation of the lowest energy subband, which leads to an increase in the electron mobility at high temperature. The results explain certain long-standing discrepancies between the existing theory and experiment on electron mobility on the surface of liquid helium

  19. The assessment of different models to predict solar module temperature, output power and efficiency for Nis, Serbia

    International Nuclear Information System (INIS)

    Pantic, Lana S.; Pavlović, Tomislav M.; Milosavljević, Dragana D.; Radonjic, Ivana S.; Radovic, Miodrag K.; Sazhko, Galina

    2016-01-01

    Five different models for calculating solar module temperature, output power and efficiency for sunny days with different solar radiation intensities and ambient temperatures are assessed in this paper. Thereafter, modeled values are compared to the experimentally obtained values for the horizontal solar module in Nis, Serbia. The criterion for determining the best model was based on the statistical analysis and the agreement between the calculated and the experimental values. The calculated values of solar module temperature are in good agreement with the experimentally obtained ones, with some variations over and under the measured values. The best agreement between calculated and experimentally obtained values was for summer months with high solar radiation intensity. The nonlinear model for calculating the output power is much better than the linear model and at the same time predicts better the total electrical energy generated by the solar module during the day. The nonlinear model for calculating the solar module efficiency predicts the efficiency higher than the STC (Standard Test Conditions) value of solar module efficiency for all conditions, while the linear model predicts the solar module efficiency very well. This paper provides a simple and efficient guideline to estimate relevant parameters of a monocrystalline silicon solar module under the moderate-continental climate conditions. - Highlights: • Linear model for solar module temperature gives accurate predictions for August. • The nonlinear model better predicts the solar module power than the linear model. • For calculating solar module power for Nis we propose the nonlinear model. • For calculating solar model efficiency for Nis we propose adoption of linear model. • The adopted models can be used for calculations throughout the year.

  20. Implementation of multiple intelligences theory in the English language course syllabus at the University of Nis Medical School.

    Science.gov (United States)

    Bakić-Mirić, Natasa

    2010-01-01

    Theory of multiple intelligences (MI) is considered an innovation in learning the English language because it helps students develop all eight intelligences that, on the other hand, represent ways people understand the world around them, solve problems and learn. They are: verbal/linguistic, logical/mathematical, visual/spatial, bodily/kinaesthetic, musical/rhythmic, interpersonal, intrapersonal and naturalist. Also, by focusing on the problem-solving activities, teachers, by implementing theory of multiple intelligences, encourage students not only to build their existing language knowledge but also learn new content and skills. The objective of this study has been to determine the importance of implementation of the theory of multiple intelligences in the English language course syllabus at the University of Nis Medical School. Ways in which the theory of multiple intelligences has been implemented in the English language course syllabus particularly in one lecture for junior year students of pharmacy in the University of Nis Medical School. The English language final exam results from February 2009 when compared with the final exam results from June 2007 prior to the implementation of MI theory showed the following: out of 80 junior year students of pharmacy, 40 obtained grade 10 (outstanding), 16 obtained grade 9 (excellent), 11 obtained grade 8 (very good), 4 obtained grade 7 (good) and 9 obtained grade 6 (pass). No student failed. The implementation of the theory of multiple intelligences in the English language course syllabus at the University of Nis Medical School has had a positive impact on learning the English language and has increased students' interest in language learning. Genarally speaking, this theory offers better understanding of students' intelligence and greater appreciation of their strengths. It provides numerous opportunities for students to use and develop all eight intelligences not just the few they excel in prior to enrolling in a

  1. A Level Set Discontinuous Galerkin Method for Free Surface Flows - and Water-Wave Modeling

    DEFF Research Database (Denmark)

    Grooss, Jesper

    2005-01-01

    We present a discontinuous Galerkin method on a fully unstructured grid for the modeling of unsteady incompressible fluid flows with free surfaces. The surface is modeled by a level set technique. We describe the discontinuous Galerkin method in general, and its application to the flow equations...... equations in time are discussed. We investigate theory of di erential algebraic equations, and connect the theory to current methods for solving the unsteady fluid flow equations. We explore the use of a semi-implicit spectral deferred correction method having potential to achieve high temporal order....... The deferred correction method is applied on the fluid flow equations and show good results in periodic domains. We describe the design of a level set method for the free surface modeling. The level set utilize the high order accurate discontinuous Galerkin method fully and represent smooth surfaces very...

  2. Monitoring sea level and sea surface temperature trends from ERS satellites

    DEFF Research Database (Denmark)

    Andersen, Ole Baltazar; Knudsen, Per; Beckley, B.

    2002-01-01

    Data from the two ESA satellites ERS-1 and ERS-2 are used in global and regional analysis of sea level and sea surface temperature trends over the last, 7.8 years. T he ERS satellites and in the future the ENVISAT satellite provide unique opportunity for monitoring both changes in sea level and s...

  3. Origin of Fermi-level pinning at GaAs surfaces and interfaces

    Science.gov (United States)

    Colleoni, Davide; Miceli, Giacomo; Pasquarello, Alfredo

    2014-12-01

    Through first-principles simulation methods, we assign the origin of Fermi-level pinning at GaAs surfaces and interfaces to the bistability between the As-As dimer and two As dangling bonds, which transform into each other upon charge trapping. This defect is shown to be naturally formed both at GaAs surfaces upon oxygen deposition and in the near-interface substoichiometric oxide. Using electron-counting arguments, we infer that the identified defect occurs in opposite charge states. The Fermi-level pinning then results from the amphoteric nature of this defect which drives the Fermi level to its defect level. These results account for the experimental characterization at both GaAs surfaces and interfaces within a unified picture, wherein the role of As antisites is elucidated.

  4. Atomic layer deposition of NiS and its application as cathode material in dye sensitized solar cell

    Energy Technology Data Exchange (ETDEWEB)

    Mahuli, Neha [Center for Research in Nanotechnology and Sciences, Indian Institute of Technology Bombay, Powai, Mumbai 400076 (India); Sarkar, Shaibal K., E-mail: shaibal.sarkar@iitb.ac.in [Department of Energy Science and Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076 (India)

    2016-01-15

    Nickel sulfide (NiS) is grown by atomic layer deposition (ALD) using sequential exposures of bis(2,2,6,6-tetramethylheptane-3,5-dionate)nickel(II) [Ni(thd){sub 2}] and hydrogen sulfide (H{sub 2}S) at 175 °C. Complementary combinations of in situ and ex situ characterization techniques are used to understand the deposition chemistry and the nature of film growth. The saturated growth rate of ca. 0.21 Å per ALD cycle is obtained, which is constant within the ALD temperature window (175–250 °C). As deposited films on glass substrates are found polycrystalline without any preferred orientation. Electrical transport measurement reveals degenerative/semimetallic characteristics with a carrier concentration of ca. 9 × 10{sup 22} cm{sup −3} at room temperature. The ALD grown NiS thin film demonstrates high catalytic activity for the reduction of I{sup −}/I{sub 3}{sup −} electrolyte that opens its usage as cost-effective counter electrode in dye sensitized solar cells, replacing Pt.

  5. Manufacturing microsystems-on-a-chip with 5-level surface micromachining technology

    Energy Technology Data Exchange (ETDEWEB)

    Sniegowski, J.; Rodgers, M.S.

    1998-05-01

    An agile microsystem manufacturing technology has been developed that provides unprecedented 5 levels of independent polysilicon surface-micromachine films for the designer. Typical surface-micromachining processes offer a maximum of 3 levels, making this the most complex surface-micromachining process technology developed to date. Leveraged from the extensive infrastructure present in the microelectronics industry, the manufacturing method of polysilicon surface-micromachining offers similar advantages of high-volume, high-reliability, and batch-fabrication to microelectromechanical systems (MEMS) as has been accomplished with integrated circuits (ICs). These systems, comprised of microscopic-sized mechanical elements, are laying the foundation for a rapidly expanding, multi-billion dollar industry 2 which impacts the automotive, consumer product, and medical industries to name only a few.

  6. Influence of Amide/Amine vs Nis-Amide Coordination in Nickel Superoxide Dismutase

    Energy Technology Data Exchange (ETDEWEB)

    Neupane,K.; Shearer, J.

    2006-01-01

    Nickel superoxide dismutase (NiSOD) is a mononuclear nickel-containing metalloenzyme that catalyzes the disproportionation of superoxide by cycling between Ni{sup II} and Ni{sup III} oxidation states. In the reduced Ni{sup II} oxidation state, the metal center is ligated by two cysteinate sulfurs, one amide nitrogen, and one amine nitrogen (from the N-terminus), while in the oxidized Ni{sup III} state, an imidazole nitrogen coordinates to the metal center. Herein, we expand on a previous report in which we described a functional metallopeptide-based NiSOD model compound [Ni{sup II}(SOD{sup M1})] (SOD{sup M1} = H{sub 2}N-HCDLPCGVYDPA-COOH) by exploring how acylation of the N-terminus (producing [Ni{sup II}(SOD{sup M1}-Ac)]) influences the properties of the metallopeptide. Titration results, GPC data, and mass-spectrometry data demonstrate that Ni{sup II} coordinates to SOD{sup M1}-Ac in a 1:1 ratio, while variable pH studies show that Ni{sup II} coordination is strong at a pH of 7.5 and above but not observed below a pH of 6.2. This is higher than [Ni{sup II}(SOD{sup M1})] by {approx}1.0 pH unit consistent with bisamide ligation. Ni K-edge XAS demonstrates that the Ni{sup II} center is coordinated in a square-planar NiN{sub 2}S{sub 2} coordination environment with Ni-N distances of 1.846(4) {angstrom} and Ni-S distances of 2.174(3) {angstrom}. Comparison of the electronic absorption and CD spectrum of [Ni{sup II}(SOD{sup M1})] versus [Ni{sup II}(SOD{sup M1}-Ac)] in conjunction with time-dependent DFT calculations suggests a decrease in Ni covalency in the acylated versus unacylated metallopeptide. This decrease in covalency was also supported by DFT calculations and Ni L-edge XAS. [Ni{sup II}(SOD{sup M1}-Ac)] has a quasireversible Ni{sup II}/Ni{sup III} redox couple of 0.49(1) V vs Ag/AgCl, which represents a -0.2 V shift compared with [Ni{sup II}(SOD{sup M1})], while the peak separation suggests a change in the coordination environment upon oxidation (i.e., axial

  7. Tooth Surface Level Caries Progression in the Primary Dentition among Preschool Children.

    Science.gov (United States)

    Ismail, Amid I; Lim, Sungwoo; Tellez, Marisol

    2015-01-01

    The objective of this paper is to describe primary tooth surface level caries progression, over 2 years, based on the severity of the caries lesions. Data were collected from 790 low-income African-American preschool children in Detroit, Mich., USA. The caregivers of the children (aged 0-5 years) completed interviews and the dyad of child-caregiver completed dental examinations in 2002-2004 (baseline) and in 2004-2005 (follow-up). Caries were measured using the International Caries Detection and Assessment System (ICDAS). The caries status of tooth surfaces was classified into initial (ICDAS 1-2), moderate (ICDAS 3-4) and extensive (ICDAS 5-6) stages. Counts of tooth surfaces with progression, by baseline caries severity level, were used to compute rate ratios (RRs) relative to sound stages. RRs were also computed for type of tooth surfaces and frequency of intake of soda consumption at baseline. After adjusting for confounders, caries progression was more likely to occur in tooth surfaces with any baseline caries relative to sound surfaces. For surfaces with initial caries, the rate of progression to moderate caries was 9.6 times higher than that of sound surfaces. Surfaces with initial and moderate caries progressed to extensive caries 6.1 and 20.6 times, respectively, relative to sound surfaces. Baseline soda consumption was not associated with the RR of caries progression. In conclusion, the staging of caries identifies different progression risks and significant emphasis should be placed on secondary prevention of initial lesions as well as on primary prevention. © 2015 S. Karger AG, Basel.

  8. Gait Characteristics Associated with Trip-Induced Falls on Level and Sloped Irregular Surfaces

    Directory of Open Access Journals (Sweden)

    Andrew Merryweather

    2011-11-01

    Full Text Available Same level falls continue to contribute to an alarming number of slip/trip/fall injuries in the mining workforce. The objective of this study was to investigate how walking on different surface types and transverse slopes influences gait parameters that may be associated with a trip event. Gait analysis was performed for ten subjects on two orientations (level and sloped on smooth, hard surface (control and irregular (gravel, larger rocks surfaces. Walking on irregular surfaces significantly increased toe clearance compared to walking on the smooth surface. There was a significant (p < 0.05 decrease in cadence (steps/min, stride length (m, and speed (m/s from control to gravel to larger rocks. Significant changes in external rotation and increased knee flexion while walking on irregular surfaces were observed. Toe and heel clearance requirements increased on irregular surfaces, which may provide an explanation for trip-induced falls; however, the gait alterations observed in the experienced workers used as subjects would likely improve stability and recovery from a trip.

  9. Probability distribution for the Gaussian curvature of the zero level surface of a random function

    Science.gov (United States)

    Hannay, J. H.

    2018-04-01

    A rather natural construction for a smooth random surface in space is the level surface of value zero, or ‘nodal’ surface f(x,y,z)  =  0, of a (real) random function f; the interface between positive and negative regions of the function. A physically significant local attribute at a point of a curved surface is its Gaussian curvature (the product of its principal curvatures) because, when integrated over the surface it gives the Euler characteristic. Here the probability distribution for the Gaussian curvature at a random point on the nodal surface f  =  0 is calculated for a statistically homogeneous (‘stationary’) and isotropic zero mean Gaussian random function f. Capitalizing on the isotropy, a ‘fixer’ device for axes supplies the probability distribution directly as a multiple integral. Its evaluation yields an explicit algebraic function with a simple average. Indeed, this average Gaussian curvature has long been known. For a non-zero level surface instead of the nodal one, the probability distribution is not fully tractable, but is supplied as an integral expression.

  10. Feasibility of dual reporter gene in rat myoblast cell line using human sodium iodide symporter (hNIS) and enhanced green fluorescent protein (EGFP) gene

    International Nuclear Information System (INIS)

    Lee, Yong Jin; Lee, You La; Ahn, Sohn Joo; Choi, Chang Ik; Lee, Sang Woo; Ahn, Byeong Cheol; Lee, Jae Tae

    2007-01-01

    To develop a non-invasive combined imaging method of gamma camera and optical imaging to assess rat myoblast cell line, H9c2, we constructed retrovirus containing hNIS and EGFP gene, and transfected to rat myoblast cell and monitored hNIS and EGFP expression. Rat myoblast cell line, H9C2, was transfected with hNIS and EGFP gene using retrovirus (H9C2-NG). The expression of hNIS and EGFP gene was determined by RT-PCR and fluorescence microscopy, respectively. The uptake and efflux of I-125 were measured in the transfected and wild type cell lines. Each cell line was injected to 4 flank sites (H9c2: 1X107 or 2X107, H9C2-NG: 1X107 or 2X107) in nude mouse. Scintigraphic image was performed at 3h, 1 day after H9C2 and H9C2-NG cell inoculation. We performed gamma camera and animal PET imaging to evaluate NIS expression. Also, GFP image obtained using optical imaging system. The expression of hNIS and EGFP gene was confirmed by RT-PCR. In iodide uptake, H9C2-NG cells accumulated 274.52.2 pmol/ mg protein at 30 min. But wild type cell line did not uptake iodide. In fluorescent microscopy, H9C2-NG cells were highly fluorescent than that of H9C2 cells. In iodide efflux study, 50% of radioactivity flowed out during the first 10min. Scintigraphy showed increased uptake of Tc-99m in H9c2-NG than in H9C2 for 1 day. Also, H9C2-NG cells showed high signal-to-background fluorescent spots in animal body. In this study, NIS and EGFP reporter gene were successfully transfected by a retrovirus in myoblast cell line, and the transfected cell can be easily visualized in vivo. These results suggest that NIS and EGFP gene has an excellent feasibility as a reporter gene, and it can be used to monitor cell trafficking for monitoring

  11. Spatially-varying surface roughness and ground-level air quality in an operational dispersion model

    International Nuclear Information System (INIS)

    Barnes, M.J.; Brade, T.K.; MacKenzie, A.R.; Whyatt, J.D.; Carruthers, D.J.; Stocker, J.; Cai, X.; Hewitt, C.N.

    2014-01-01

    Urban form controls the overall aerodynamic roughness of a city, and hence plays a significant role in how air flow interacts with the urban landscape. This paper reports improved model performance resulting from the introduction of variable surface roughness in the operational air-quality model ADMS-Urban (v3.1). We then assess to what extent pollutant concentrations can be reduced solely through local reductions in roughness. The model results suggest that reducing surface roughness in a city centre can increase ground-level pollutant concentrations, both locally in the area of reduced roughness and downwind of that area. The unexpected simulation of increased ground-level pollutant concentrations implies that this type of modelling should be used with caution for urban planning and design studies looking at ventilation of pollution. We expect the results from this study to be relevant for all atmospheric dispersion models with urban-surface parameterisations based on roughness. -- Highlights: • Spatially variable roughness improved performance of an operational model. • Scenario modelling explored effect of reduced roughness on air pollution. • Reducing surface roughness can increase modelled ground-level pollution. • Damped vertical mixing outweighs increased horizontal advection in model study. • Result should hold for any model with a land-surface coupling based on roughness. -- Spatially varying roughness improves model simulations of urban air pollutant dispersion. Reducing roughness does not always decrease ground-level pollution concentrations

  12. Maps of the topography of water surface levels in the Danube Delta, between the main branches

    Directory of Open Access Journals (Sweden)

    BONDAR Constantin

    2016-12-01

    Full Text Available Within the project “Hydrological Monitoring of Wetland Areas Using SAR Techniques (Hydro-SAR”, concluded by the TERRASIGNA (Romania with the European Space Agency (ESA, the task of GeoEcoMar was to track and check the correlation of data provided by InSAR techniques with ground observations and measurements in the Danube Delta. Activities in the field and laboratory enabled elaboration of maps of vector fields for the water flow directions on the Danube Delta territory, based on the relief of the water surface levels at 450, 400, 350, 300, 250, 200, 150, 100, 50 and 0 cm, measured at Tulcea hydrologic station. In order to elaborate the maps of water surface levels, the altimetric stability of hydrometric gauges from the Danube Delta territorry was checked by establishing the Earth crust subsidence in each gauge location. Interpretation of recorded data shows a relative low subsidence rate for the location of the hydrometric gauge in Tulcea (observations recorded for the period 1858-2013 selected as hydrometric reference point, with the origin of the zero of the gauge situated at 0.57 m altitude relative to the Black Sea – Sulina reference system. The paper presents isoline maps of the water surface levels on the surface of the Danube Delta between the main distributaries (Chilia – Sulina – Sf. Gheorghe, for the above mentioned water surface levels.

  13. The persistence of gender and racial disparities in vascular lower extremity amputation: an examination of HCUP-NIS data (2002-2011).

    Science.gov (United States)

    Lefebvre, Kristin M; Chevan, Julia

    2015-02-01

    The purpose of this study was to examine trends in racial and gender disparities in the severity of lower extremity amputation among individuals with peripheral artery disease (PAD) over the period of a decade (2002-2011). This is a longitudinal secondary analysis of data from the Healthcare Utilization Project Nationwide Inpatient Survey (HCUP-NIS) for the years 2002-2011. Level of amputation was determined from ICD-9-CM procedure and coded as either transfemoral (TF) or transtibial (TT). The main predictors were gender and race; covariates including age, race, income, insurance status and presence of vascular disease were incorporated as control variables in regression analysis. A total 121,587 cases of non-traumatic dysvascular amputations were identified. Female gender (odds ratio (OR) 1.35; 95% confidence interval (CI) 1.32, 1.39) and black race (OR 1.17; 95% CI 1.12, 1.23) are both significantly associated with increased odds for receiving TF amputation with no change in these odds over the decade of study. Other covariates with significant associations with TF amputation level include increased age (OR 1.03; 95% CI 0.99, 1.09), low income (OR 1.21; 95% CI 1.15, 1.27), Medicaid insurance (OR 1.36; 95% CI 1.29, 1.44), Medicare insurance (OR 1.27; 95% CI 1.21, 1.32), and cerebrovascular disease (OR 2.12; 95% CI 2.03, 2.23). In conclusion, although overall rates of amputation have decreased, disparities in level of amputation related to female gender and black race have not significantly changed over time. Higher-level amputation has significant consequences from a quality-of-life, medical and economic perspective. © The Author(s) 2015.

  14. Information non précise sur la taille du pénis en République Démocratique du Congo: à propos de 21 sources

    Science.gov (United States)

    Mulenga, Philippe Cilundika; Kazadi, Alex Bukasa

    2016-01-01

    Introduction La taille du pénis constitue une préoccupation de beaucoup des gens actuellement et certains ne sont pas satisfaits de la dimension de leur pénis comme le montre l’étude de Tiggemann en 2008. Il existe relativement peu d'études sur le pénis en érection. Cela peut refléter les tabous culturels des chercheurs ou des médecins en interaction avec les hommes qui sont dans un état d’excitation sexuelle. Toutes fois, il est important pour les personnes qui annoncent des détails sur la taille du pénis d’annoncer d’abord les repères de la mesure du pénis puis ensuite donner les chiffres que proposent les chercheurs. Méthodes Notre enquête de type descriptif transversale s’est effectuée dans les deux grandes villes de la République Démocratique du Congo à savoir la ville de Kinshasa et la ville de Lubumbashi, pendant une période de deux ans soit de Mai 2014 à Mai 2016. Au total, 21 sources d’information ont constitué notre échantillon dont 8 à Kinshasa et 13 à Lubumbashi et nous avons trouvé cela suffisant car les sujets à caractère sexuel sont souvent rares chez nous. Les paramètres étudiés étaient: la nature de la source, la précision de la technique de la mesure, la présence de référence bibliographique, la longueur annoncée du pénis. Résultats La majorité des sources d’information sont faites des émissions de radio et de télévision (23,8%), ceci pourra s’expliquer par le fait que dans notre milieu il y a de plus en plus des chaines de radio et télévision et surtout dans les grandes villes. Concernant la précision de la technique de la mesure du pénis lors du partage du message sur la taille du pénis, l’étude nous montre que la majorité des sources d’information ne signale pas cela lorsqu’elles annoncent la taille du pénis au public soit 85,7%. Plusieurs sources ne déclarent pas les références bibliographiques (57,1%). Lorsqu’on regarde même les chiffres de la taille du pénis

  15. Molecular and structural characterisation of the human sodium/iodide symporter (h N.I.S.) C-terminus and the implication of this domain in the transporter regulation; Caracterisation moleculaire et structurale de l'extremite C-Terminale du co-transporteur sodium/iode humain (h N.I.S.): Implication de ce domaine dans la regulation du transporteur

    Energy Technology Data Exchange (ETDEWEB)

    Huc, S

    2007-12-15

    The human natrium iodide symporter (h N.I.S.) is an intrinsic membrane protein expressed in thyroid cells where it allows iodide uptake and accumulation. It is composed of thirteen transmembrane helices and its ninety- three amino acids long cytosolic C-terminus presents many potential post-translational regulatory sites. A first part of the PhD work has been dedicated to the expression in a bacterial system and to the purification of the cytosolic C-terminal fragment. Biochemical and structural characterisation have revealed that this C-terminus is very flexible but prone to dimerization. The fragment has also been used as a bait to test the interactions with PDZ domain proteins spotted on a membrane. Several proteins interacting with the (natrium/iodide symporter) N.I.S. C-terminus have thus been identified and the study of their implication in the protein regulation has been initiated. A second part of the work has underlined the existence of a N.I.S. fragment co-purified with the entire protein. This fragment has been found in cells in culture stably expressing N.I.S. and also in human thyroid extracts and in rodent thyroid cells. We observed that this fragment is spontaneously associated with the entire protein. It is composed of the last 131 amino acid of the protein and so comprises the last transmembrane domain and the C-terminal extremity. The expression of a truncated form of h N.I.S., lacking the last 131 amino acids, shows that this protein is not correctly addressed to the cell membrane and cells expressing this mutated symporter cannot accumulate iodide. However, our results show that the co-expression of the two N.I.S. parts, the truncated form lacking the last 131 amino acid, and the complementary C-terminal fragment, leads to cells presenting 10 % of the activity of cells expressing the whole N.I.S.. (author)

  16. The impact of accelerometer mounting methods on the level of vibrations recorded at ground surface

    Directory of Open Access Journals (Sweden)

    Krzysztof Czech

    2014-08-01

    Full Text Available The paper presents the results of field research based on the measurements of accelerations recorded at ground surface. The source of the vibration characterized by high repetition rate of pulse parameters was light falling weight deflectometer ZFG-01. Measurements of vibrations have been carried out using top quality high-precision measuring system produced by Brüel&Kiær. Accelerometers were mounted on a sandy soil surface at the measuring points located radially at 5-m and 10-m distances from the source of vibration. The paper analyses the impact that the method of mounting accelerometers on the ground has on the level of the recorded values of accelerations of vibrations. It has been shown that the method of attaching the sensor to the surface of the ground is crucial for the credibility of the performed measurements.[b]Keywords[/b]: geotechnics, surface vibrations, ground, vibration measurement

  17. Deep layer-resolved core-level shifts in the beryllium surface

    DEFF Research Database (Denmark)

    Aldén, Magnus; Skriver, Hans Lomholt; Johansson, Börje

    1993-01-01

    Core-level energy shifts for the beryllium surface region are calculated by means of a Green’s function technique within the tight-binding linear muffin-tin orbitals method. Both initial- and final-state effects in the core-ionization process are fully accounted for. Anomalously large energy shifts...

  18. Surface shift of the occupied and unoccupied 4f levels of the rare-earth metals

    DEFF Research Database (Denmark)

    Aldén, Magnus; Johansson, Börje; Skriver, Hans Lomholt

    1995-01-01

    The surface energy shifts of the occupied and unoccupied 4f levels for the lanthanide metals have been calculated from first principles by means of a Green’s-function technique within the tight-binding linear muffin-tin orbitals method. We use the concept of complete screening to identify the occ...

  19. Water level observations from Unmanned Aerial Vehicles for improving estimates of surface water-groundwater interaction

    DEFF Research Database (Denmark)

    Bandini, Filippo; Butts, Michael; Vammen Jacobsen, Torsten

    2017-01-01

    . However, traditional river gauging stations are normally spaced too far apart to capture spatial patterns in the water surface, while spaceborne observations have limited spatial and temporal resolution. UAVs (Unmanned Aerial Vehicles) can retrieve river water level measurements, providing: i) high...

  20. A comparative study of the phosphate levels in some surface and ...

    African Journals Online (AJOL)

    The levels of total phosphate in selected surface water and groundwater bodies from Manzini and Lubombo regions of Swaziland were determined using UV spectroscopic method. Samples were collected from three rivers (upstream and downstream of each), three industrial effluents, one reservoir, one pond, one tap water ...

  1. Monitoring the variability of sea level and surface circulation with satellite altimetry

    NARCIS (Netherlands)

    Volkov, Denis L. "Jr"

    2004-01-01

    Variability in the ocean plays an important role in determining global weather and climate conditions. The advent of satellite altimetry has significantly facilitated the study of the variability of sea level and surface circulation. Satellites provide high-quality regular and nearly global

  2. Levels of Cd, Hg and Zn in some surface waters from the Eastern ...

    African Journals Online (AJOL)

    Total trace metals levels - Cd, Hg and Zn, which may affect human health and the "health" of the aquatic ecosystem, were determined in the Umtata, Buffalo, Keiskamma and Tyume Rivers and in the Sandile and Umtata Dams. These elements were also determined in sediment samples from some of these surface waters.

  3. Severity of MIH findings at tooth surface level among German school children.

    Science.gov (United States)

    Petrou, M A; Giraki, M; Bissar, A-R; Wempe, C; Schäfer, M; Schiffner, U; Beikler, T; Schulte, A G; Splieth, C H

    2015-06-01

    This study was to investigate the distribution and clinical characteristics of teeth diagnosed with MIH at surface and defect type level in a cohort of German children. The study cohort included 242 children diagnosed with MIH which had been recorded during the compulsory dental school examinations of 20 German primary schools. The subjects had been enrolled by cluster sampling. All children attended the second to fourth grade (age 7-10 years, mean 8.1 ± 0.8). The children were examined by five calibrated examiners (kappa = 0.9) after tooth brushing. The recording comprised teeth, surfaces, type and severity of MIH defects and was conducted using a portable light, mirrors and cotton rolls. MIH was registered according to the EAPD criteria. Defects teeth were first permanent molars (71.4 %) followed by the maxillary central incisors (15.6 %). The most common defects were demarcated opacities (82.2 %), while the remaining 17.8 % of the affected teeth exhibited severe enamel defects. The most frequently affected surface in molars was the occlusal surface (72.4 %); in incisors, it was the buccal surface (73.5 %). There were no atypical restorations in the affected incisors. Different types of MIH defects at various surfaces of the same tooth were common. The number of affected tooth surfaces was positively correlated with the severity of MIH at child (p teeth. The knowledge of the intra-oral distribution and severity of MIH findings at the enamel surface level is important for assessing the treatment needs.

  4. Statistical analysis of global surface temperature and sea level using cointegration methods

    DEFF Research Database (Denmark)

    Schmidt, Torben; Johansen, Søren; Thejll, Peter

    2012-01-01

    Global sea levels are rising which is widely understood as a consequence of thermal expansion and melting of glaciers and land-based ice caps. Due to the lack of representation of ice-sheet dynamics in present-day physically-based climate models being unable to simulate observed sea level trends......, semi-empirical models have been applied as an alternative for projecting of future sea levels. There is in this, however, potential pitfalls due to the trending nature of the time series. We apply a statistical method called cointegration analysis to observed global sea level and land-ocean surface air...... temperature, capable of handling such peculiarities. We find a relationship between sea level and temperature and find that temperature causally depends on the sea level, which can be understood as a consequence of the large heat capacity of the ocean. We further find that the warming episode in the 1940s...

  5. Serum levels of vitamin A, visual function and ocular surface after bariatric surgery

    Directory of Open Access Journals (Sweden)

    Luana Paula Nogueira de Araújo BRANDÃO

    Full Text Available ABSTRACT BACKGROUND Bariatric surgery is the most effective treatment for severe obesity, but the surgery increases the risk of developing nutritional deficiencies, such as vitamin A deficiency. In human metabolism, vitamin A plays a role in vision. OBJECTIVE To evaluate serum vitamin A, visual function and ocular surface of patients undergoing bariatric surgery. METHODS A cross-sectional and analytical study was conduced with 28 patients undergoing bariatric surgery for at least 6 months. Ophthalmologic evaluation was done through color vision test, contrast sensitivity test, ocular surface tests and confocal microscopy, as well as vitamin A serum measurement. RESULTS Vertical sleeve gastrectomy was performed in seven (25.0% patients and Roux -en-Y gastric by-pass in 21 (75.0%. Mean serum vitamin A level was 1.7±0.5 µmoL/L. Most patients (60.7% had symptoms of dry eye. Five (17.9% patients had contrast sensitivity impairment and 18 (64.3% color vision changes. In the group of patients undergoing Roux -en-Y gastric by-pass , mean vitamin A levels were 1.8±0.6 µmoL/L, whereas they were 1.7±0.5 µmoL/L in patients submitted to the restrictive technique vertical sleeve gastrectomy . The analysis of the influence of serum levels of vitamin A in the visual function and ocular surface was performed by Pearson correlation test and there was no significant correlation between any of the variables and vitamin A. CONCLUSION There was no influence of the bariatric surgery technique used on serum vitamin A levels, on the visual function or on the ocular surface. Moreover, there was no correlation between serum levels of vitamin A and the visual function or the ocular surface changes.

  6. Serum levels of vitamin A, visual function and ocular surface after bariatric surgery.

    Science.gov (United States)

    Brandão, Luana Paula Nogueira de Araújo; Vilar, Lucio; Cavalcanti, Bernardo Menelau; Brandão, Pedro Henrique Amorim; Arantes, Tiago Eugênio Faria E; Campos, Josemberg Marins

    2017-01-01

    - Bariatric surgery is the most effective treatment for severe obesity, but the surgery increases the risk of developing nutritional deficiencies, such as vitamin A deficiency. In human metabolism, vitamin A plays a role in vision. - To evaluate serum vitamin A, visual function and ocular surface of patients undergoing bariatric surgery. - A cross-sectional and analytical study was conduced with 28 patients undergoing bariatric surgery for at least 6 months. Ophthalmologic evaluation was done through color vision test, contrast sensitivity test, ocular surface tests and confocal microscopy, as well as vitamin A serum measurement. - Vertical sleeve gastrectomy was performed in seven (25.0%) patients and Roux -en-Y gastric by-pass in 21 (75.0%). Mean serum vitamin A level was 1.7±0.5 µmoL/L. Most patients (60.7%) had symptoms of dry eye. Five (17.9%) patients had contrast sensitivity impairment and 18 (64.3%) color vision changes. In the group of patients undergoing Roux -en-Y gastric by-pass , mean vitamin A levels were 1.8±0.6 µmoL/L, whereas they were 1.7±0.5 µmoL/L in patients submitted to the restrictive technique vertical sleeve gastrectomy . The analysis of the influence of serum levels of vitamin A in the visual function and ocular surface was performed by Pearson correlation test and there was no significant correlation between any of the variables and vitamin A. - There was no influence of the bariatric surgery technique used on serum vitamin A levels, on the visual function or on the ocular surface. Moreover, there was no correlation between serum levels of vitamin A and the visual function or the ocular surface changes.

  7. Report on the degradation of the environment at the site of NIS Novi Sad oil refinery and remediation measures

    International Nuclear Information System (INIS)

    Pavlovic, P.; Pavlovic, M.; Ivankovic, M.; Sokolovic, S.

    2002-01-01

    Before the NATO bombing, Refinery had available 149 tanks for the storage of crude oil, intermediate and final products, additives etc. All tanks are placed within the impermeable embankments of concrete or soil and connected to the storm and oil sewerage systems which enables the monitoring and control of of oil leakage and storm waste. During the NATO bombing practically all processing units were either destroyed or damaged. The summary of damages inflicted to the processing units is given. During the NATO bombing campaign over 51% of the available storage capacity was destroyed and over 34% of it was severely damaged. A summary of available, destroyed and damaged tank capacities in the NIS Novi Sad Oil Refinery is given. (author)

  8. Identification of Potential Sodium Iodide Symporter (NIS) Inhibitors in ToxCast Phase1_v2 Chemical Library Using in vitro Radioactive Iodide Uptake (RAIU) Assay

    Science.gov (United States)

    Identification of Potential Sodium Iodide Symporter (NIS) Inhibitors in ToxCast Phase1_v2 Chemical Library Using in vitro Radioactive Iodide Uptake (RAIU) Assay Jun Wang1,2, Daniel R. Hallinger2, Ashley S. Murr2, Angela R. Buckalew1, Tammy E. Stoker2, Susan C. Laws21Oak Ridge In...

  9. The rhizoferrin biosynthetic gene in the fungal pathogen Rhizopus delemar is a novel member of the NIS gene family.

    Science.gov (United States)

    Carroll, Cassandra S; Grieve, Clark L; Murugathasan, Indu; Bennet, Andrew J; Czekster, Clarissa M; Liu, Huanting; Naismith, James; Moore, Margo M

    2017-08-01

    Iron is essential for growth and in low iron environments such as serum many bacteria and fungi secrete ferric iron-chelating molecules called siderophores. All fungi produce hydroxamate siderophores with the exception of Mucorales fungi, which secrete rhizoferrin, a polycarboxylate siderophore. Here we investigated the biosynthesis of rhizoferrin by the opportunistic human pathogen, Rhizopus delemar. We searched the genome of R. delemar 99-880 for a homologue of the bacterial NRPS-independent siderophore (NIS) protein, SfnaD, that is involved in biosynthesis of staphyloferrin A in Staphylococcus aureus. A protein was identified in R. delemar with 22% identity and 37% similarity with SfnaD, containing an N-terminal IucA/IucC family domain, and a C-terminal conserved ferric iron reductase FhuF-like transporter domain. Expression of the putative fungal rhizoferrin synthetase (rfs) gene was repressed by iron. The rfs gene was cloned and expressed in E.coli and siderophore biosynthesis from citrate and diaminobutane was confirmed using high resolution LC-MS. Substrate specificity was investigated showing that Rfs produced AMP when oxaloacetic acid, tricarballylic acid, ornithine, hydroxylamine, diaminopentane and diaminopropane were employed as substrates. Based on the production of AMP and the presence of a mono-substituted rhizoferrin, we suggest that Rfs is a member of the superfamily of adenylating enzymes. We used site-directed mutagenesis to mutate selected conserved residues predicted to be in the Rfs active site. These studies revealed that H484 is essential for Rfs activity and L544 may play a role in amine recognition by the enzyme. This study on Rfs is the first characterization of a fungal NIS enzyme. Future work will determine if rhizoferrin biosynthesis is required for virulence in Mucorales fungi. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Mapping Hydrophobicity on the Protein Molecular Surface at Atom-Level Resolution

    Science.gov (United States)

    Nicolau Jr., Dan V.; Paszek, Ewa; Fulga, Florin; Nicolau, Dan V.

    2014-01-01

    A precise representation of the spatial distribution of hydrophobicity, hydrophilicity and charges on the molecular surface of proteins is critical for the understanding of the interaction with small molecules and larger systems. The representation of hydrophobicity is rarely done at atom-level, as this property is generally assigned to residues. A new methodology for the derivation of atomic hydrophobicity from any amino acid-based hydrophobicity scale was used to derive 8 sets of atomic hydrophobicities, one of which was used to generate the molecular surfaces for 35 proteins with convex structures, 5 of which, i.e., lysozyme, ribonuclease, hemoglobin, albumin and IgG, have been analyzed in more detail. Sets of the molecular surfaces of the model proteins have been constructed using spherical probes with increasingly large radii, from 1.4 to 20 Å, followed by the quantification of (i) the surface hydrophobicity; (ii) their respective molecular surface areas, i.e., total, hydrophilic and hydrophobic area; and (iii) their relative densities, i.e., divided by the total molecular area; or specific densities, i.e., divided by property-specific area. Compared with the amino acid-based formalism, the atom-level description reveals molecular surfaces which (i) present an approximately two times more hydrophilic areas; with (ii) less extended, but between 2 to 5 times more intense hydrophilic patches; and (iii) 3 to 20 times more extended hydrophobic areas. The hydrophobic areas are also approximately 2 times more hydrophobicity-intense. This, more pronounced “leopard skin”-like, design of the protein molecular surface has been confirmed by comparing the results for a restricted set of homologous proteins, i.e., hemoglobins diverging by only one residue (Trp37). These results suggest that the representation of hydrophobicity on the protein molecular surfaces at atom-level resolution, coupled with the probing of the molecular surface at different geometric resolutions

  11. Statistical analysis of global surface air temperature and sea level using cointegration methods

    DEFF Research Database (Denmark)

    Schmith, Torben; Johansen, Søren; Thejll, Peter

    Global sea levels are rising which is widely understood as a consequence of thermal expansion and melting of glaciers and land-based ice caps. Due to physically-based models being unable to simulate observed sea level trends, semi-empirical models have been applied as an alternative for projecting...... radiative forcing as an explanatory variable, but unexpectedly find that the sea level does not depend on the forcing. We hypothesize that this is due to a long adjustment time scale of the ocean and show that the number of years of data needed to build statistical models that have the relationship expected...... of future sea levels. There is in this, however, potential pitfalls due to the trending nature of the time series. We apply a statistical method called cointegration analysis to observed global sea level and surface air temperature, capable of handling such peculiarities. We find a relationship between sea...

  12. Inhibition of miR-146b expression increases radioiodine-sensitivity in poorly differential thyroid carcinoma via positively regulating NIS expression

    Energy Technology Data Exchange (ETDEWEB)

    Li, Luchuan; Lv, Bin; Chen, Bo [Department of General Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012 (China); Guan, Ming [Department of General Surgery, Qihe People' s Hospital, Qihe, Shandong 251100 (China); Sun, Yongfeng [Department of General Surgery, Licheng District People' s Hospital, Jinan, Shandong 250115 (China); Li, Haipeng [Department of General Surgery, Caoxian People' s Hospital, Caoxian, Shandong 274400 (China); Zhang, Binbin; Ding, Changyuan; He, Shan [Department of General Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012 (China); Zeng, Qingdong, E-mail: qingdz0201@163.com [Department of General Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012 (China)

    2015-07-10

    Dedifferentiated thyroid carcinoma (DTC) with the loss of radioiodine uptake (RAIU) is often observed in clinical practice under radioiodine therapy, indicating the challenge for poor prognosis. MicroRNA (miRNA) has emerged as a promising therapeutic target in many diseases; yet, the role of miRNAs in RAIU has not been generally investigated. Based on recent studies about miRNA expression in papillary or follicular thyroid carcinomas, the expression profiles of several thyroid relative miRNAs were investigated in one DTC cell line, derived from normal DTC cells by radioiodine treatment. The top candidate miR-146b, with the most significant overexpression profiles in dedifferentiated cells, was picked up. Further research found that miR-146b could be negatively regulated by histone deacetylase 3 (HDAC3) in normal cells, indicating the correlation between miR-146b and Na{sup +}/I{sup −} symporter (NIS)-mediated RAIU. Fortunately, it was confirmed that miR-146b could regulate NIS expression/activity; what is more important, miR-146b interference would contribute to the recovery of radioiodine-sensitivity in dedifferentiated cells via positively regulating NIS. In the present study, it was concluded that NIS-mediated RAIU could be modulated by miR-146b; accordingly, miR-146b might serve as one of targets to enhance efficacy of radioactive therapy against poorly differential thyroid carcinoma (PDTC). - Highlights: • Significant upregulated miR-146b was picked up from thyroid relative miRNAs in DTC. • MiR-146b was negatively regulated by HDAC3 in normal thyroid carcinoma cells. • NIS activity and expression could be regulated by miR-146b in thyroid carcinoma. • MiR-146b inhibition could recover the decreased radioiodine-sensitivity of DTC cells.

  13. Estimation of surface UV levels based on Meteor-3/TOMS ozone data

    Energy Technology Data Exchange (ETDEWEB)

    Borisov, Y.A. [Central Aerological Observatory, Moscow (Russian Federation); Geogdzhaev, I.V. [Moscow Inst. of Physics and Technology, Moscow (Russian Federation); Khattatov, V.U. [Central Aerological Observatory, Moscow (Russian Federation)

    1995-12-31

    The major consequence of ozone layer depletion for the environment is an increase of harmful ultraviolet (UV) radiation on the Earth surface and in the upper ocean. This implies the importance of environmental UV monitoring. Since the direct global monitoring is not currently possible, indirect estimations of surface UV levels may be used based on satellite ozone data (Madronich, S. 1992). Total Ozone Mapping Spectrometer (TOMS) on board the METEOR-3 satellite provided regular set of data for such estimates. During the time of its operation (August, 1991 - December, 1994) the instrument registered several ozone hole events over Antarctica, when ozone levels dropped by as much as 60 % from their unperturbed values. Probably even more alarming ozone depletions were observed over highly populated regions of middle latitudes of northern hemisphere. Radiative transfer modeling was used to convert METEOR-3/TOMS daily ozone values into regional and global maps of biologically active UV. Calculations demonstrate the effect on surface UV levels produced by ozone hole over Antarctica and ozone depletions over the territory of Russia (March, 1994). UV contour lines deviate from the normal appearance which is determined by growing southward solar elevation. UV contour lines are almost perpendicular to the ozone ones in the ozone depletions areas. The 30 % ozone depletion, over Siberia caused more than 30 % increase in noontime erythemal UV levels, which is equivalent to 10-15 degrees southward latitude displacement. Higher UV radiation increases were found in ozone hole over South America (October 1992) equivalent to about 20 degrees southward displacement

  14. Two Surface-Tension Formulations For The Level Set Interface-Tracking Method

    International Nuclear Information System (INIS)

    Shepel, S.V.; Smith, B.L.

    2005-01-01

    The paper describes a comparative study of two surface-tension models for the Level Set interface tracking method. In both models, the surface tension is represented as a body force, concentrated near the interface, but the technical implementation of the two options is different. The first is based on a traditional Level Set approach, in which the surface tension is distributed over a narrow band around the interface using a smoothed Delta function. In the second model, which is based on the integral form of the fluid-flow equations, the force is imposed only in those computational cells through which the interface passes. Both models have been incorporated into the Finite-Element/Finite-Volume Level Set method, previously implemented into the commercial Computational Fluid Dynamics (CFD) code CFX-4. A critical evaluation of the two models, undertaken in the context of four standard Level Set benchmark problems, shows that the first model, based on the smoothed Delta function approach, is the more general, and more robust, of the two. (author)

  15. GHRSST Level 4 RTO Terra MODIS-AMSRE Night North America Regional Blended Sea Surface Temperature Analysis (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily on an operational basis at the JPL Physical...

  16. GHRSST Level 4 ODYSSEA North-Western Europe Regional Foundation Sea Surface Temperature Analysis (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily on an operational basis at Ifremer/CERSAT...

  17. GHRSST Level 4 MUR Global Foundation Sea Surface Temperature Analysis (v4.1) (GDS versions 1 and 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced as a retrospective dataset (four day latency) and...

  18. GHRSST Level 4 REMO_OI_SST_5km Regional Foundation Sea Surface Temperature Analysis (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature (SST) analysis produced daily on an operational basis by the...

  19. GHRSST Level 4 CMC0.2deg Global Foundation Sea Surface Temperature Analysis (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature (SST) analysis produced daily on an operational basis at the Canadian...

  20. GHRSST Level 4 DMI_OI North Sea and Baltic Sea Regional Foundation Sea Surface Temperature Analysis (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily on an operational basis by the Danish...

  1. GHRSST Level 4 RTO Aqua MODIS-AMSRE Night North America Regional Blended Sea Surface Temperature Analysis (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily on an operational basis at the JPL Physical...

  2. GHRSST Level 4 RTO Terra MODIS-AMSRE Day North America Regional Blended Sea Surface Temperature Analysis (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily on an operational basis at the JPL Physical...

  3. GHRSST Level 4 CMC0.1deg Global Foundation Sea Surface Temperature Analysis (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature (SST) analysis produced daily on an operational basis at the Canadian...

  4. GHRSST Level 4 MW_IR_OI Global Foundation Sea Surface Temperature analysis (GDS versions 1 and 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) global Level 4 sea surface temperature analysis produced daily on a 0.81 degree grid at Remote Sensing...

  5. GHRSST Level 4 RTO Aqua MODIS-AMSRE Day North America Regional Blended Sea Surface Temperature Analysis (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 4 sea surface temperature analysis produced daily on an operational basis at the JPL Physical...

  6. 6430.1A Compliance Matrix for 241-SY-101 Surface Level Rise Remediation Project

    International Nuclear Information System (INIS)

    ERHART, M.F.

    1999-01-01

    Tank 241-SY-101 (SY-101) has recently exhibited a steady waste surface level growth. A path forward to mitigate the SY-101 surface level growth issue has been developed. The project has been directed to install the necessary equipment to transfer 380-570m 3 (100,000-150,000 gallons) of waste from SY-101 to SY-102 before the waste elevation reached the region of the tank where the transition from a double to a single shell tank occurs. The purpose of this document is to record the design attributes of the RAPID mitigation system which fulfill the requirements specified in DOE order 6430.1A as it relates to the 241-SY-101 RAPID Mitigation System

  7. Site characterization field manual for near surface geologic disposal of low-level radioactive waste

    International Nuclear Information System (INIS)

    McCray, J.G.; Nowatzki, E.A.

    1985-01-01

    This field manual has been developed to aid states and regions to do a detailed characterization of a proposed near-surface low-level waste disposal site. The field manual is directed at planners, staff personnel and experts in one discipline to acquaint them with the requirements of other disciplines involved in site characterization. While it can provide a good review, it is not designed to tell experts how to do their job within their own discipline

  8. Carcinome épidermoide du pénis | Naim | Pan African Medical Journal

    African Journals Online (AJOL)

    , who consulted, 6 years before, for an ulcerated burgeoning in the anterior surface of the penile bleeding on contact, which extended along the penis, without involving the glans penis. Evolution was marked by tumor progression with ...

  9. Toward Improved Application of SMOS and Aquarius Level-2 Sea-surface Salinity Products

    Science.gov (United States)

    Zhang, Y.; Bayler, E. J.; Baker-Yeboah, S.

    2016-02-01

    A large numbers of quality flags and descriptors are associated with the various geophysical, retrieval and geometrical filters provided with Level-2 (swath) sea-surface salinity (SSS) data from the European Space Agency's (ESA) Soil Moisture - Ocean Salinity (SMOS) mission and the National Aeronautics and Space Administration's (NASA) Aquarius mission. The best application of the SSS data relies on completely understanding the impact on data quality from choices for the thresholds of the different filters available for the Level-2 products. Quick-look Level-3 (gridded) datasets generated directly from SMOS and Aquarius Level-2 products will improve the use of satellite SSS products in NOAA's data applications and in situ data comparisons, as well as for near-real-time data quality monitoring of Level-2 products. Consequently, NCEI generated 1×1 degree binned Level-3 SSS products from SMOS and Aquarius Level-2 data, minimizing latency to within 24 hours of Level-2 data availability. These satellite SSS products include SMOS monthly and 3-day (global coverage) means and Aquarius monthly and 7-day (global coverage) means. In this study, we compare the NCEI satellite binned Level-3 products to the JPL PODAAC official Aquarius and SMOS Barcelona Expert Center (BEC) Level-3 SSS products. Also, we present a comparison of the NCEI Level-3 SSS product with the NOAA/NCEI World Ocean Atlas (WOA) in situ gridded data. Results indicate consistency and a good match of NCEI-binned Level-3 SSS data with other datasets for open ocean areas, with some bias apparent in coastal and high-latitude regions.

  10. Potential energy surface and rovibrational energy levels of the H2-CS van der Waals complex.

    Science.gov (United States)

    Denis-Alpizar, Otoniel; Stoecklin, Thierry; Halvick, Philippe; Dubernet, Marie-Lise; Marinakis, Sarantos

    2012-12-21

    Owing to its large dipole, astrophysicists use carbon monosulfide (CS) as a tracer of molecular gas in the interstellar medium, often in regions where H(2) is the most abundant collider. Predictions of the rovibrational energy levels of the weakly bound complex CS-H(2) (not yet observed) and also of rate coefficients for rotational transitions of CS in collision with H(2) should help to interpret the observed spectra. This paper deals with the first goal, i.e., the calculation of the rovibrational energy levels. A new four-dimensional intermolecular potential energy surface for the H(2)-CS complex is presented. Ab initio potential energy calculations were carried out at the coupled-cluster level with single and double excitations and a perturbative treatment of triple excitations, using a quadruple-zeta basis set and midbond functions. The potential energy surface was obtained by an analytic fit of the ab initio data. The equilibrium structure of the H(2)-CS complex is found to be linear with the carbon pointing toward H(2) at the intermolecular separation of 8.6 a(o). The corresponding well depth is -173 cm(-1). The potential was used to calculate the rovibrational energy levels of the para-H(2)-CS and ortho-H(2)-CS complexes. The present work provides the first theoretical predictions of these levels. The calculated dissociation energies are found to be 35.9 cm(-1) and 49.9 cm(-1), respectively, for the para and ortho complexes. The second virial coefficient for the H(2)-CS pair has also been calculated for a large range of temperature. These results could be used to assign future experimental spectra and to check the accuracy of the potential energy surface.

  11. Wetland Ecohydrology: stochastic description of water level fluctuations across the soil surface

    Science.gov (United States)

    Tamea, S.; Muneepeerakul, R.; Laio, F.; Ridolfi, L.; Rodriguez-Iturbe, I.

    2009-12-01

    Wetlands provide a suite of social and ecological critical functions such as being habitats of disease-carrying vectors, providing buffer zones against hurricanes, controlling sediment transport, filtering nutrients and contaminants, and a repository of great biological diversity. More recently, wetlands have also been recognized as crucial for carbon storage in the context of global climate change. Despite such importance, quantitative approaches to many aspects of wetlands are far from adequate. Therefore, improving our quantitative understanding of wetlands is necessary to our ability to maintain, manage, and restore these invaluable environments. In wetlands, hydrologic factors and ecosystem processes interplay and generate unique characteristics and a delicate balance between biotic and abiotic elements. The main hydrologic driver of wetland ecosystems is the position of the water level that, being above or below ground, determines the submergence or exposure of soil. When the water level is above the soil surface, soil saturation and lack of oxygen causes hypoxia, anaerobic functioning of microorganisms and anoxic stress in plants, that might lead to the death of non-adapted organisms. When the water level lies below the soil surface, the ecosystem becomes groundwater-dependent, and pedological and physiological aspects play their role in the soil water balance. We propose here a quantitative description of wetland ecohydrology, through a stochastic process-based water balance, driven by a marked compound Poisson noise representing rainfall events. The model includes processes such as rainfall infiltration, evapotranspiration, capillary rise, and the contribution of external water bodies, which are quantified in a simple yet realistic way. The semi-analytical steady-state probability distributions of water level spanning across the soil surface are validated with data from the Everglades (Florida, USA). The model and its results allow for a quantitative

  12. Monitoring the variability of sea level and surface circulation with satellite altimetry

    Science.gov (United States)

    Volkov, Denis L. "Jr"

    2004-10-01

    Variability in the ocean plays an important role in determining global weather and climate conditions. The advent of satellite altimetry has significantly facilitated the study of the variability of sea level and surface circulation. Satellites provide high-quality regular and nearly global measurements enabling us to study the oceanic variability on the spatial scales from the size of an eddy to global, and on the temporal scales from weeks to interannual and longer. This thesis demonstrates how satellite altimetry measurements can be used to study the mesoscale, seasonal and interannual variability of sea level and surface circulation. Oceanic variability at these time scales is mainly induced by the variations of heat and fresh water fluxes (buoyancy fluxes) at air-sea interface, the variations of heat and salt budget due to the advection of water masses with different properties, eddy generation mechanisms due to the instability of oceanic currents, Rossby waves, etc. It is shown how the sea level in the extratropical North Atlantic Ocean was changing during the investigated time interval from 1993 to 2003. The mesoscale, seasonal and inter-annual modes of the variability are revealed, and the magnitude and relative contribution of each mode to the total variance is assessed. The inter-annual change of the sea surface height in the northern North Atlantic, measured with altimetry, is coupled with in situ observations along the transatlantic section AR7E, repeated almost every year from 1990 to 2003 in the framework of the WOCE (World Ocean Circulation Experiment) and CLIVAR (CLImate VARiability) hydrographic programs. This allowed interpreting the observed inter-annual change of sea level in terms of changes in the sea water properties and the distribution of water masses. A comparative analysis of changes observed in the extratropical North Atlantic and in the extratropical North Pacific is performed. The magnitudes, spatial patterns, and also trends of the

  13. Emotional responses during repeated sprint intervals performed on level, downhill and uphill surfaces.

    Science.gov (United States)

    Baron, Bertrand; Guilloux, Bertrand; Begue, Mylène; Uriac, Stéphane

    2015-01-01

    The purpose of this study was to test emotional responses during sprint intervals performed on a level, down and up surface. Fifty trained participants performed a maximal effort during a 60-m sprint and 10 repetitions of 60 m running sprints on a level, down and up surface on a 5.9% slope. Running speeds, emotional responses and heart rate were measured. Self-selected speeds were correlated with the rating of perceived exertion, the affective balance, the desire to stop and the resources needed for the task in all conditions whereas the pleasure, the desire to continue and the capacity to realise the task were correlated with speeds only during level and uphill running. Mean values of emotional parameters were significantly different (P emotional responses was just translated, i.e. most of the slope between the evolution of emotional parameters and the repetitions were not significantly different whereas Y-intercepts were different. Consented effort is highly correlated with the resources needed for the task (P < 0.001, r(2) = 0.72). We propose that the difference in the resources needed for the task between level, downhill and uphill running (F 2, 1499 = 166.5, P < 0.001, Eta(2) = 0.18) is the most important key that explains our results.

  14. Development, Characterization, and Optimization of Protein Level in Date Bars Using Response Surface Methodology

    Directory of Open Access Journals (Sweden)

    Muhammad Nadeem

    2012-01-01

    Full Text Available This project was designed to produce a nourishing date bar with commercial value especially for school going children to meet their body development requirements. Protein level of date bars was optimized using response surface methodology (RSM. Economical and underutilized sources, that is, whey protein concentrate and vetch protein isolates, were explored for protein supplementation. Fourteen date bar treatments were produced using a central composite design (CCD with 2 variables and 3 levels for each variable. Date bars were then analyzed for nutritional profile. Proximate composition revealed that addition of whey protein concentrate and vetch protein isolates improved the nutritional profile of date bars. Protein level, texture, and taste were considerably improved by incorporating 6.05% whey protein concentrate and 4.35% vetch protein isolates in date bar without affecting any sensory characteristics during storage. Response surface methodology was observed as an economical and effective tool to optimize the ingredient level and to discriminate the interactive effects of independent variables.

  15. Surface-type repository for low and intermediate level radioactive waste in the Republic of Croatia

    International Nuclear Information System (INIS)

    Kucar-Dragicevic, S.; Zarkovic, V.; Subasic, D.

    1995-01-01

    The low-level intermediate-level (LL/IL) radioactive waste repository siting and construction project is one of the activities related to establishing the rad waste management system in the Republic of Croatia. The repository project design is one in an array of project activities which also include the site selection procedure and public attitude issues. The prepared design documentation gives technical, safety and financial background relevant for making a final decision on the waste disposal type, and it includes the technological, mechanical, civil and financial documentation on the preliminary/basic design level. During the last few years, the preliminary design has been prepared and safety assessment conducted for the tunnel-type LL/IL rad waste repository. As the surface-type repository is one of alternatives for final disposal the design documentation for that repository type was prepared during 1994. (author)

  16. Reduction of Fermi level pinning and recombination at polycrystalline CdTe surfaces by laser irradiation

    Science.gov (United States)

    Simonds, Brian J.; Kheraj, Vipul; Palekis, Vasilios; Ferekides, Christos; Scarpulla, Michael A.

    2015-06-01

    Laser processing of polycrystalline CdTe is a promising approach that could potentially increase module manufacturing throughput while reducing capital expenditure costs. For these benefits to be realized, the basic effects of laser irradiation on CdTe must be ascertained. In this study, we utilize surface photovoltage spectroscopy (SPS) to investigate the changes to the electronic properties of the surface of polycrystalline CdTe solar cell stacks induced by continuous-wave laser annealing. The experimental data explained within a model consisting of two space charge regions, one at the CdTe/air interface and one at the CdTe/CdS junction, are used to interpret our SPS results. The frequency dependence and phase spectra of the SPS signal are also discussed. To support the SPS findings, low-temperature spectrally-resolved photoluminescence and time-resolved photoluminescence were also measured. The data show that a modest laser treatment of 250 W/cm2 with a dwell time of 20 s is sufficient to reduce the effects of Fermi level pinning at the surface due to surface defects.

  17. Reduction of Fermi level pinning and recombination at polycrystalline CdTe surfaces by laser irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Simonds, Brian J. [Electrical and Computer Engineering, University of Utah, Salt Lake City, Utah 84112 (United States); Kheraj, Vipul [Electrical and Computer Engineering, University of Utah, Salt Lake City, Utah 84112 (United States); Department of Applied Physics, S. V. National Institute of Technology, Surat 395 007 (India); Palekis, Vasilios; Ferekides, Christos [Electrical Engineering, University of South Florida, Tampa, Florida 33620 (United States); Scarpulla, Michael A., E-mail: scarpulla@eng.utah.edu [Electrical and Computer Engineering, University of Utah, Salt Lake City, Utah 84112 (United States); Materials Science and Engineering, University of Utah, Salt Lake City, Utah 84112 (United States)

    2015-06-14

    Laser processing of polycrystalline CdTe is a promising approach that could potentially increase module manufacturing throughput while reducing capital expenditure costs. For these benefits to be realized, the basic effects of laser irradiation on CdTe must be ascertained. In this study, we utilize surface photovoltage spectroscopy (SPS) to investigate the changes to the electronic properties of the surface of polycrystalline CdTe solar cell stacks induced by continuous-wave laser annealing. The experimental data explained within a model consisting of two space charge regions, one at the CdTe/air interface and one at the CdTe/CdS junction, are used to interpret our SPS results. The frequency dependence and phase spectra of the SPS signal are also discussed. To support the SPS findings, low-temperature spectrally-resolved photoluminescence and time-resolved photoluminescence were also measured. The data show that a modest laser treatment of 250 W/cm{sup 2} with a dwell time of 20 s is sufficient to reduce the effects of Fermi level pinning at the surface due to surface defects.

  18. Exceptionally crystalline and conducting acid doped polyaniline films by level surface assisted solution casting approach

    Energy Technology Data Exchange (ETDEWEB)

    Puthirath, Anand B.; Varma, Sreekanth J.; Jayalekshmi, S., E-mail: jayalekshmi@cusat.ac.in [Division for Research in Advanced Materials, Department of Physics, Cochin University of Science and Technology, Cochin, Kerala 682022 (India); Methattel Raman, Shijeesh [Nanophotonic and Optoelectronic Devices Laboratory, Department of Physics, Cochin University of Science and Technology, Cochin, Kerala 682022 (India)

    2016-04-18

    Emeraldine salt form of polyaniline (PANI) was synthesized by chemical oxidative polymerisation method using ammonium persulfate as oxidant. Resultant emeraldine salt form of PANI was dedoped using ammonia solution and then re-doped with camphor sulphonic acid (CSA), naphthaline sulphonic acid (NSA), hydrochloric acid (HCl), and m-cresol. Thin films of these doped PANI samples were deposited on glass substrates using solution casting method with m-cresol as solvent. A level surface was employed to get homogeneous thin films of uniform thickness. Detailed X-ray diffraction studies have shown that the films are exceptionally crystalline. The crystalline peaks observed in the XRD spectra can be indexed to simple monoclinic structure. FTIR and Raman spectroscopy studies provide convincing explanation for the exceptional crystallinity observed in these polymer films. FESEM and AFM images give better details of surface morphology of doped PANI films. The DC electrical conductivity of the samples was measured using four point probe technique. It is seen that the samples also exhibit quite high DC electrical conductivity, about 287 S/cm for CSA doped PANI, 67 S/cm for NSA doped PANI 65 S/cm for HCl doped PANI, and just below 1 S/cm for m-cresol doped PANI. Effect of using the level surface for solution casting is studied and correlated with the observed crystallinity.

  19. Self-consistent Green’s-function technique for bulk and surface impurity calculations: Surface core-level shifts by complete screening

    DEFF Research Database (Denmark)

    Aldén, M.; Abrikosov, I. A.; Johansson, B.

    1994-01-01

    of the frozen-core and atomic-sphere approximation but, in addition, includes the dipole contribution to the intersphere potential. Within the concept of complete screening, we identify the surface core-level binding-energy shift with the surface segregation energy of a core-ionized atom and use the Green......'s-function impurity technique in a comprehensive study of the surface core-level shifts (SCLS) of the 4d and 5d transition metals. In those cases, where observed data refer to single crystals, we obtain good agreement with experiment, whereas the calculations typically underestimate the measured shift obtained from...... a polycrystalline surface. Comparison is made with independent theoretical data for the surface core-level eigenvalue shift, and the much debated role of the so-called initial-and final-state contributions to the SCLS is discussed....

  20. Past and future sea-level change from the surface mass balance of glaciers

    Directory of Open Access Journals (Sweden)

    B. Marzeion

    2012-11-01

    Full Text Available We present estimates of sea-level change caused by the global surface mass balance of glaciers, based on the reconstruction and projection of the surface mass balance of all the individual glaciers of the world, excluding the ice sheets in Greenland and Antarctica. The model is validated using a leave-one-glacier-out cross-validation scheme against 3997 observed surface mass balances of 255 glaciers, and against 756 geodetically observed, temporally integrated volume and surface area changes of 341 glaciers. When forced with observed monthly precipitation and temperature data, the glaciers of the world are reconstructed to have lost mass corresponding to 114 ± 5 mm sea-level equivalent (SLE between 1902 and 2009. Using projected temperature and precipitation anomalies from 15 coupled general circulation models from the Coupled Model Intercomparison Project phase 5 (CMIP5 ensemble, they are projected to lose an additional 148 ± 35 mm SLE (scenario RCP26, 166 ± 42 mm SLE (scenario RCP45, 175 ± 40 mm SLE (scenario RCP60, or 217 ± 47 mm SLE (scenario RCP85 during the 21st century. Based on the extended RCP scenarios, glaciers are projected to approach a new equilibrium towards the end of the 23rd century, after having lost either 248 ± 66 mm SLE (scenario RCP26, 313 ± 50 mm SLE (scenario RCP45, or 424 ± 46 mm SLE (scenario RCP85. Up until approximately 2100, ensemble uncertainty within each scenario is the biggest source of uncertainty for the future glacier mass loss; after that, the difference between the scenarios takes over as the biggest source of uncertainty. Ice mass loss rates are projected to peak 2040 ∼ 2050 (RCP26, 2050 ∼ 2060 (RCP45, 2070 ∼ 2090 (RCP60, or 2070 ∼ 2100 (RCP85.

  1. Surface Water Connectivity, Flow Pathways and Water Level Fluctuation in a Cold Region Deltaic Ecosystem

    Science.gov (United States)

    Peters, D. L.; Niemann, O.; Skelly, R.; Monk, W. A.; Baird, D. J.

    2017-12-01

    The Peace-Athabasca Delta (PAD) is a 6000 km2 deltaic floodplain ecosystem of international importance (Wood Buffalo National Park, Ramsar Convention, UNESCO World Heritage, and SWOT satellite water level calibration/validation site). The low-relief floodplain formed at the confluence of the Peace, Athabasca and Birch rivers with Lake Athabasca. More than 1000 wetland and lake basins have varying degrees of connectivity to the main flow system. Hydroperiod and water storage is influenced by ice-jam and open-water inundations and prevailing semi-arid climate that control water drawdown. Prior studies have identified pathways of river-to-wetland floodwater connection and historical water level fluctuation/trends as a key knowledge gaps, limiting our knowledge of deltaic ecosystem status and potential hydroecological responses to climate change and upstream water alterations to flow contributions. To address this knowledge gap, surface elevation mapping of the PAD has been conducted since 2012 using aerial remote sensing Light Detection and Ranging (LiDAR), plus thousands of ground based surface and bathymetric survey points tied to Global Positioning System (GPS) were obtained. The elevation information was used to develop a high resolution digital terrain model to simulate and investigate surface water connectivity. Importantly, the surveyed areas contain a set of wetland monitoring sites where ground-based surface water connectivity, water level/depth, water quality, and aquatic ecology (eg, vegetation, macroinvertebrate and muskrat) have been examined. The goal of this presentation is to present an assessment of: i) surface water fluctuation and connectivity for PAD wetland sites; ii) 40+ year inter-annual hydroperiod reconstruction for a perched basin using a combination of field measurements, remote sensing estimates, and historical documents; and iii) outline an approach to integrate newly available hydro-bio-geophysical information into a novel, multi

  2. Surface-enhanced Raman scattering biosensor for DNA detection on nanoparticle island substrates

    DEFF Research Database (Denmark)

    Yuan, Scott Wu; Ho, Ho Pui; Lee, Rebecca K.Y.

    2009-01-01

    We present a study on the surface-enhanced Raman scattering (SERS) properties of Ag nanoparticle island substrates (NIS) and their applications for target oligonucleotide (OND) detection. It has been found that the surface nanostructure of NIS samples can be controlled with a good degree...... on the use of the detection OND with or without the gold nanoparticle (Au-NP). Our results confirm that, when the detection OND is coupled to the Au-NP, a better sensitivity for the target OND detection, in terms of a wider dynamic range and a lower detection limit (0:4 fM versus 1nM without Au-NP), would...

  3. Atomic Level Cleaning of Poly Methyl Methacrylate Residues from the Graphene Surface Using Radiolized Water at High Temperatures (Postprint)

    Science.gov (United States)

    2017-09-05

    AFRL-RX-WP-JA-2017-0321 ATOMIC LEVEL CLEANING OF POLY-METHYL- METHACRYLATE RESIDUES FROM THE GRAPHENE SURFACE USING RADIOLIZED WATER AT...COVERED (From - To) 9 March 2017 Interim 8 September 2014 – 9 February 2017 4. TITLE AND SUBTITLE ATOMIC LEVEL CLEANING OF POLY-METHYL- METHACRYLATE...graphene surfaces and can only provide atomically clean graphene surfaces in areas as large as ˜10-4 µm2. Here, we transfer CVD-grown graphene using

  4. The SMAP Level 4 Surface and Root-zone Soil Moisture (L4_SM) Product

    Science.gov (United States)

    Reichle, Rolf; Crow, Wade; Koster, Randal; Kimball, John

    2010-01-01

    The Soil Moisture Active and Passive (SMAP) mission is being developed by NASA for launch in 2013 as one of four first-tier missions recommended by the U.S. National Research Council Committee on Earth Science and Applications from Space in 2007. The primary science objectives of SMAP are to enhance understanding of land surface controls on the water, energy and carbon cycles, and to determine their linkages. Moreover, the high resolution soil moisture mapping provided by SMAP has practical applications in weather and seasonal climate prediction, agriculture, human health, drought and flood decision support. In this paper we describe the assimilation of SMAP observations for the generation of the planned SMAP Level 4 Surface and Root-zone Soil Moisture (L4_SM) product. The SMAP mission makes simultaneous active (radar) and passive (radiometer) measurements in the 1.26-1.43 GHz range (L-band) from a sun-synchronous low-earth orbit. Measurements will be obtained across a 1000 km wide swath using conical scanning at a constant incidence angle (40 deg). The radar resolution varies from 1-3 km over the outer 70% of the swath to about 30 km near the center of the swath. The radiometer resolution is 40 km across the entire swath. The radiometer measurements will allow high-accuracy but coarse resolution (40 km) measurements. The radar measurements will add significantly higher resolution information. The radar is however very sensitive to surface roughness and vegetation structure. The combination of the two measurements allows optimal blending of the advantages of each instrument. SMAP directly observes only surface soil moisture (in the top 5 cm of the soil column). Several of the key applications targeted by SMAP, however, require knowledge of root zone soil moisture (approximately top 1 m of the soil column), which is not directly measured by SMAP. The foremost objective of the SMAP L4_SM product is to fill this gap and provide estimates of root zone soil moisture

  5. Comparison pesticide residue levels in the surface of Bertam River in Cameron Highlands, Pahang

    Energy Technology Data Exchange (ETDEWEB)

    Haron, S. H., E-mail: ismail@ukm.edu.my; Ismail, B. S., E-mail: sthumaira@yahoo.com [School of Environmental and Natural Resource Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia 43600 UKM, Bangi, Selangor (Malaysia)

    2015-09-25

    The presence of pesticide residues in the surface water of Bertam River in the agricultural areas of Cameron Highlands in Pahang, Malaysia was monitored from May to October 2014. The sampling sites were located at 10 sampling points along the Bertam River in the vegetable planting areas. The extraction method of the pesticide (organophosphate/pyrethroid) from the river samples used solid phase extraction followed by gas chromatography (with electron capture detector, ECD). Insecticides, cypermethrin and chlorpyrifos were found in the surface water of Bertam River. High level concentrations of those insecticides in the river were observed during the period from May to October 2014, a period which included both seasons (wet and dry seasons). The highest concentration of 2.66 µg/mL and 1.23 µg/mL of cypermethrin was observed during the wet and dry seasons respectively. This could be due to the frequent usage of the above-mentioned insecticides coupled with contamination that could have originated from the application sites. Meanwhile, the lowest concentration detected in the surface water was chlorpyrifos (0.11 µg/mL and 0.17 µg/mL) during the dry and wet seasons, respectively.

  6. Comparison pesticide residue levels in the surface of Bertam River in Cameron Highlands, Pahang

    International Nuclear Information System (INIS)

    Haron, S. H.; Ismail, B. S.

    2015-01-01

    The presence of pesticide residues in the surface water of Bertam River in the agricultural areas of Cameron Highlands in Pahang, Malaysia was monitored from May to October 2014. The sampling sites were located at 10 sampling points along the Bertam River in the vegetable planting areas. The extraction method of the pesticide (organophosphate/pyrethroid) from the river samples used solid phase extraction followed by gas chromatography (with electron capture detector, ECD). Insecticides, cypermethrin and chlorpyrifos were found in the surface water of Bertam River. High level concentrations of those insecticides in the river were observed during the period from May to October 2014, a period which included both seasons (wet and dry seasons). The highest concentration of 2.66 µg/mL and 1.23 µg/mL of cypermethrin was observed during the wet and dry seasons respectively. This could be due to the frequent usage of the above-mentioned insecticides coupled with contamination that could have originated from the application sites. Meanwhile, the lowest concentration detected in the surface water was chlorpyrifos (0.11 µg/mL and 0.17 µg/mL) during the dry and wet seasons, respectively

  7. A case study on biomass burning aerosols: effects on aerosol optical properties and surface radiation levels

    Directory of Open Access Journals (Sweden)

    A. Arola

    2007-08-01

    Full Text Available In spring 2006, biomass burning aerosols from eastern Europe were transported extensively to Finland, and to other parts of northern Europe. They were observed as far as in the European Arctic. In the first part of this paper, temporal and spatial evolution and transport of these biomass burning aerosols are monitored with MODIS retrieved aerosol optical depth (AOD imagery at visible wavelengths (0.55 μm. Comparison of MODIS and AERONET AOD is conducted at Tõravere, Estonia. Then trajectory analyses, as well as MODIS Fire Mapper products are used to better understand the type and origin of the air masses. During the studied four-week period AOD values ranged from near zero up to 1.2 at 0.55 μm and the linear correlation between MODIS and AERONET was very high (~0.97. Temporal variability observed within this four-week period was also rather well explained by the trajectory analysis in conjunction with the fire detections produced by the MODIS Rapid Response System. In the second part of our study, the surface measurements of global and UV radiation at Jokioinen, Finland are used to study the effect of this haze episode on the levels of surface radiation. We found reductions up to 35% in noon-time surface UV irradiance (at 340 nm as compared to typical aerosol conditions. For global (total solar radiation, the reduction was always smaller, in line with the expected wavelength dependence of the aerosol effect.

  8. Realization of the ITS-90 over the Temperature Range 83 K to 693 K at the National Institute for Standards NIS-Egypt

    Science.gov (United States)

    Gamal, M.; Ali, K.; Moussa, M. R.

    2003-09-01

    The thermometry group of the National Institute for Standards (NIS) has realized the International Temperature Scale 1990 (ITS-90), as defined over the temperature range from 83 K to 2200 °C. This work concerns the temperature range from 83 K up to 693 K only. A brief review is given of the techniques and apparatus used, the source and purity of the fixed points in this range, cell designs and uncertainties of our realization.

  9. Low-Cost Alternative for the Measurement of Water Levels in Surface Water Streams

    Directory of Open Access Journals (Sweden)

    Luis E. PEÑA

    2017-11-01

    Full Text Available Flood risk management and water resources planning involve a deep knowledge of surface streams so that mitigation strategies and climate change adaptations can be implemented. Commercially, there is a wide range of technologies for the measurement of hydroclimatic variables; however, many of these technologies may not be affordable for institutions with limited budgets. This paper has two main objectives: 1 Present the design of an ultrasound-based water level measurement system, and 2 Propose a methodological alternative for the development of instruments, according to the needs of institutions conducting monitoring of surface waterbodies. To that end, the proposed methodology is based on selection processes defined according to the specific needs of each waterbody. The prototype was tested in real-world scale, with the potential to obtain accurate measurements. Lastly, we present the design of the ultrasound-based water level measurement instrument, which can be built at a low cost. Low-cost instruments can potentially contribute to the sustainable instrumental autonomy of environmental entities and help define measurement and data transmission standards based on the specific requirements of the monitoring.

  10. Fabrication of Surface Level Cu/Si Cp Nano composites by Friction Stir Processing Route

    International Nuclear Information System (INIS)

    Srinivasan, R. C.; Karunanithi, M.

    2015-01-01

    Friction stir processing (FSP) technique has been successfully employed as low energy consumption route to prepare copper based surface level nano composites reinforced with nano sized silicon carbide particles (Si Cp). The effect of FSP parameters such as tool rotational speed, processing speed, and tool tilt angle on microstructure and microhardness was investigated. Single pass FSP was performed based on Box-Behnken design at three factors in three levels. A cluster of blind holes 2 mm in diameter and 3 mm in depth was used as particulate deposition technique in order to reduce the agglomeration problem during composite fabrication. K-type thermocouples were used to measure temperature histories during FSP. The results suggest that the heat generation during FSP plays a significant role in deciding the microstructure and microhardness of the surface composites. Microstructural observations revealed a uniform dispersion of nano sized Si Cp without any agglomeration problem and well bonded with copper matrix at different process parameter combinations. X-ray diffraction study shows that no intermetallic compound was produced after processing. The microhardness of nano composites was remarkably enhanced and about 95% more than that of copper matrix

  11. Fabrication of Surface Level Cu/SiCp Nanocomposites by Friction Stir Processing Route

    Directory of Open Access Journals (Sweden)

    Cartigueyen Srinivasan

    2015-01-01

    Full Text Available Friction stir processing (FSP technique has been successfully employed as low energy consumption route to prepare copper based surface level nanocomposites reinforced with nanosized silicon carbide particles (SiCp. The effect of FSP parameters such as tool rotational speed, processing speed, and tool tilt angle on microstructure and microhardness was investigated. Single pass FSP was performed based on Box-Behnken design at three factors in three levels. A cluster of blind holes 2 mm in diameter and 3 mm in depth was used as particulate deposition technique in order to reduce the agglomeration problem during composite fabrication. K-type thermocouples were used to measure temperature histories during FSP. The results suggest that the heat generation during FSP plays a significant role in deciding the microstructure and microhardness of the surface composites. Microstructural observations revealed a uniform dispersion of nanosized SiCp without any agglomeration problem and well bonded with copper matrix at different process parameter combinations. X-ray diffraction study shows that no intermetallic compound was produced after processing. The microhardness of nanocomposites was remarkably enhanced and about 95% more than that of copper matrix.

  12. Surface feature characterization test plan: Conceptual design of a high level nuclear waste repository in salt

    International Nuclear Information System (INIS)

    1984-06-01

    This report presents the Surface Feature Characterization Test Plan for conceptual design. The Test Plan is part of the surface feature characterization program for conceptual design which will obtain information on site topography, hydrology, stratigraphy, and soil and rock engineering properties. The information will be obtained by the Geologic Project Manager (GPM). This Test Plan provides guidance to the GPM as to (1) the kinds of data to be collected, (2) anticipated methods, (3) the level of detail required, (4) interpretation to be made, and (5) the format for presentation. Based on this Test Plan and on conditions at the site that is selected, the GPM will develop an Activity Plan describing the methods to be used in obtaining the needed information. For each item of information, the Test Plan describes those facilities which require it for their design. The GPM can then determine the appropriate methods and level of effort for obtaining the information, taking into account its use and conditions at the selected site. 7 figs., 3 tabs

  13. Reduction Expansion Synthesis as Strategy to Control Nitrogen Doping Level and Surface Area in Graphene.

    Science.gov (United States)

    Canty, Russell; Gonzalez, Edwin; MacDonald, Caleb; Osswald, Sebastian; Zea, Hugo; Luhrs, Claudia C

    2015-10-16

    Graphene sheets doped with nitrogen were produced by the reduction-expansion (RES) method utilizing graphite oxide (GO) and urea as precursor materials. The simultaneous graphene generation and nitrogen insertion reactions are based on the fact that urea decomposes upon heating to release reducing gases. The volatile byproducts perform two primary functions: (i) promoting the reduction of the GO and (ii) providing the nitrogen to be inserted in situ as the graphene structure is created. Samples with diverse urea/GO mass ratios were treated at 800 °C in inert atmosphere to generate graphene with diverse microstructural characteristics and levels of nitrogen doping. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to study the microstructural features of the products. The effects of doping on the samples structure and surface area were studied by X-ray diffraction (XRD), Raman Spectroscopy, and Brunauer Emmet Teller (BET). The GO and urea decomposition-reduction process as well as nitrogen-doped graphene stability were studied by thermogravimetric analysis (TGA) coupled with mass spectroscopy (MS) analysis of the evolved gases. Results show that the proposed method offers a high level of control over the amount of nitrogen inserted in the graphene and may be used alternatively to control its surface area. To demonstrate the practical relevance of these findings, as-produced samples were used as electrodes in supercapacitor and battery devices and compared with conventional, thermally exfoliated graphene.

  14. Reduction Expansion Synthesis as Strategy to Control Nitrogen Doping Level and Surface Area in Graphene

    Directory of Open Access Journals (Sweden)

    Russell Canty

    2015-10-01

    Full Text Available Graphene sheets doped with nitrogen were produced by the reduction-expansion (RES method utilizing graphite oxide (GO and urea as precursor materials. The simultaneous graphene generation and nitrogen insertion reactions are based on the fact that urea decomposes upon heating to release reducing gases. The volatile byproducts perform two primary functions: (i promoting the reduction of the GO and (ii providing the nitrogen to be inserted in situ as the graphene structure is created. Samples with diverse urea/GO mass ratios were treated at 800 °C in inert atmosphere to generate graphene with diverse microstructural characteristics and levels of nitrogen doping. Scanning electron microscopy (SEM and transmission electron microscopy (TEM were used to study the microstructural features of the products. The effects of doping on the samples structure and surface area were studied by X-ray diffraction (XRD, Raman Spectroscopy, and Brunauer Emmet Teller (BET. The GO and urea decomposition-reduction process as well as nitrogen-doped graphene stability were studied by thermogravimetric analysis (TGA coupled with mass spectroscopy (MS analysis of the evolved gases. Results show that the proposed method offers a high level of control over the amount of nitrogen inserted in the graphene and may be used alternatively to control its surface area. To demonstrate the practical relevance of these findings, as-produced samples were used as electrodes in supercapacitor and battery devices and compared with conventional, thermally exfoliated graphene.

  15. PHOTOMETRIC STEREO SHAPE-AND-ALBEDO-FROM-SHADING FOR PIXEL-LEVEL RESOLUTION LUNAR SURFACE RECONSTRUCTION

    Directory of Open Access Journals (Sweden)

    W. C. Liu

    2017-07-01

    Full Text Available Shape and Albedo from Shading (SAfS techniques recover pixel-wise surface details based on the relationship between terrain slopes, illumination and imaging geometry, and the energy response (i.e., image intensity captured by the sensing system. Multiple images with different illumination geometries (i.e., photometric stereo can provide better SAfS surface reconstruction due to the increase in observations. Photometric stereo SAfS is suitable for detailed surface reconstruction of the Moon and other extra-terrestrial bodies due to the availability of photometric stereo and the less complex surface reflecting properties (i.e., albedo of the target bodies as compared to the Earth. Considering only one photometric stereo pair (i.e., two images, pixel-variant albedo is still a major obstacle to satisfactory reconstruction and it needs to be regulated by the SAfS algorithm. The illumination directional difference between the two images also becomes an important factor affecting the reconstruction quality. This paper presents a photometric stereo SAfS algorithm for pixel-level resolution lunar surface reconstruction. The algorithm includes a hierarchical optimization architecture for handling pixel-variant albedo and improving performance. With the use of Lunar Reconnaissance Orbiter Camera - Narrow Angle Camera (LROC NAC photometric stereo images, the reconstructed topography (i.e., the DEM is compared with the DEM produced independently by photogrammetric methods. This paper also addresses the effect of illumination directional difference in between one photometric stereo pair on the reconstruction quality of the proposed algorithm by both mathematical and experimental analysis. In this case, LROC NAC images under multiple illumination directions are utilized by the proposed algorithm for experimental comparison. The mathematical derivation suggests an illumination azimuthal difference of 90 degrees between two images is recommended to achieve

  16. Photometric Stereo Shape-And for Pixel-Level Resolution Lunar Surface Reconstruction

    Science.gov (United States)

    Liu, W. C.; Wu, B.

    2017-07-01

    Shape and Albedo from Shading (SAfS) techniques recover pixel-wise surface details based on the relationship between terrain slopes, illumination and imaging geometry, and the energy response (i.e., image intensity) captured by the sensing system. Multiple images with different illumination geometries (i.e., photometric stereo) can provide better SAfS surface reconstruction due to the increase in observations. Photometric stereo SAfS is suitable for detailed surface reconstruction of the Moon and other extra-terrestrial bodies due to the availability of photometric stereo and the less complex surface reflecting properties (i.e., albedo) of the target bodies as compared to the Earth. Considering only one photometric stereo pair (i.e., two images), pixel-variant albedo is still a major obstacle to satisfactory reconstruction and it needs to be regulated by the SAfS algorithm. The illumination directional difference between the two images also becomes an important factor affecting the reconstruction quality. This paper presents a photometric stereo SAfS algorithm for pixel-level resolution lunar surface reconstruction. The algorithm includes a hierarchical optimization architecture for handling pixel-variant albedo and improving performance. With the use of Lunar Reconnaissance Orbiter Camera - Narrow Angle Camera (LROC NAC) photometric stereo images, the reconstructed topography (i.e., the DEM) is compared with the DEM produced independently by photogrammetric methods. This paper also addresses the effect of illumination directional difference in between one photometric stereo pair on the reconstruction quality of the proposed algorithm by both mathematical and experimental analysis. In this case, LROC NAC images under multiple illumination directions are utilized by the proposed algorithm for experimental comparison. The mathematical derivation suggests an illumination azimuthal difference of 90 degrees between two images is recommended to achieve minimal error in

  17. Geothermal energy use in terms of a more balanced & sustainable urban-rural development of Southeast Serbia, with focus on Nis region

    Directory of Open Access Journals (Sweden)

    Jovanović Aleksandar

    2017-01-01

    Full Text Available The surrounding of Nis has been known for various geothermal manifestations (see Figure 3 and 4. The city itself has direct use of Nis Spa, where a couple of sites have been used for balneology and where heating systems have been installed. However, other local resources in Nis surrounding are little known. Also, Sokobanja has a long history of thermal waters 'use throughout its rich history, from the Antiquity throughout the middle ages and Turkish rule. This is also present in towns of Bela Palanka and Svrljig in South-East Serbian region surrounding Nis. These resources can be used for supplying the cities and villages with heat in the future. More importantly, communities in local towns in the region can be supported by more proficient use of geothermal potentials, as this idea supports the alleviated concentration of inhabitants in the region. It supports local renewable energy sources and a greater ration between potentials and actual use of geothermal sources, which tends to be very low in Serbian cities and rural places. In this paper, these resources are going to be presented, for the community in Serbia to have an insight and to be reminded of its potentials and significance for regional development and local resource utilization. Built heritage and urban-architectural wholes in some of these towns and in the villages, are neglected and geothermal resources in their vicinity underused. A more organized use of geothermal potentials can lead to their regenerations. It can support the idea of a more balanced rural-urban development of the region of Nis. However, geothermal energy can also be beneficial for future regional energy planning and cooperation between towns and villages in South-Eastern Serbian regions like Nis region. And this can be an important strategy in regional planning and energy planning for the future, once the economic crisis would stop to prevail in Serbia. The authors of this paper point out to the long

  18. In Situ Fabrication of CoS and NiS Nanomaterials Anchored on Reduced Graphene Oxide for Reversible Lithium Storage.

    Science.gov (United States)

    Tan, Yingbin; Liang, Ming; Lou, Peili; Cui, Zhonghui; Guo, Xiangxin; Sun, Weiwei; Yu, Xuebin

    2016-06-15

    CoS and NiS nanomaterials anchored on reduced graphene oxide (rGO) sheets, synthesized via combination of hydrothermal with sulfidation process, are studied as high-capacity anode materials for the reversible lithium storage. The obtained CoS nanofibers and NiS nanoparticles are uniformly dispersed on rGO sheets without aggregation, forming the sheet-on-sheet composite structure. Such nanoarchitecture can not only facilitate ion/electron transport along the interfaces, but also effectively prevent metal-sulfide nanomaterials aggregation during the lithium reactions. Both the rGO-supported CoS nanofibers (NFs) and NiS nanoparticles (NPs) show superior lithium storage performance. In particular, the CoS NFs-rGO electrodes deliver the discharge capacity as high as 939 mA h g(-1) after the 100th cycle at 100 mA g(-1) with Coulombic efficiency above 98%. This strategy for construction of such composite structure can also synthesize other metal-sulfide-rGO nanomaterials for high-capacity lithium-ion batteries.

  19. Exfoliated carbon nitride nanosheets decorated with NiS as an efficient noble-metal-free visible-light-driven photocatalyst for hydrogen evolution.

    Science.gov (United States)

    Lu, Yongtao; Chu, Dongmei; Zhu, Mingshan; Du, Yukou; Yang, Ping

    2015-07-14

    A binary composite composed of two dimensional (2D) ultrathin carbon nitride (C3N4) nanosheets and NiS nanoparticles was synthesized and applied as a noble-metal-free photocatalyst for hydrogen evolution under visible light irradiation. The ultrathin nanosheets of C3N4 were obtained by a facile liquid exfoliation method and used as 2D supports for the deposition of NiS nanoparticles. In the binary composite, the ultrathin C3N4 nanosheets acted as a visible light responding semiconductor, and the NiS nanoparticles served as a noble-metal-free cocatalyst. The binary composite with an optimized composition gave a hydrogen evolution rate comparable to that of Pt modified C3N4. Moreover, compared to bulk C3N4, the exfoliated C3N4 nanosheets distinctly improve the photocatalytic performance for hydrogen evolution. The photocatalytic results combined with photoelectrochemical experiments show that C3N4 with an ultrathin structure promotes the electron-hole separation and transportation during the process of the photoinduced hydrogen evolution. This study displays a facile method to build a low-cost but effective photocatalyst for hydrogen production under visible light irradiation.

  20. Synthesis of porous NiS thin films on Ni foam substrate via an electrodeposition route and its application in lithium-ion batteries

    International Nuclear Information System (INIS)

    Ruan, Hongcheng; Li, Yafeng; Qiu, Heyuan; Wei, Mingdeng

    2014-01-01

    Graphical abstract: The porous NiS thin films on Ni foam substrate were fabricated for the first time by an electrodeposition route and then used directly as an anode for lithium-ion batteries, which exhibited larger capacity and good cycle stability. -- Highlights: • The porous NiS on Ni foam substrate were fabricated by an electrodeposition route. • NiS/Ni thin films were used as the electrode material in lithium-ion batteries. • The cell fabricated by NiS/Ni exhibited larger capacity and good cycle stability. -- Abstract: Electrodeposition, a convenient approach, has been used for fabricating porous NiS thin films on Ni foam substrate. The obtained NiS/Ni thin films were characterized by scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy and energy dispersive spectrometry. Furthermore, the electrodeposited NiS/Ni thin films were first used as the anode for lithium-ion intercalation and exhibited large capacities and good cycling stability

  1. A Response Surface Methodology for Bi-Level Integrated System Synthesis (BLISS)

    Science.gov (United States)

    Altus, Troy David; Sobieski, Jaroslaw (Technical Monitor)

    2002-01-01

    The report describes a new method for optimization of engineering systems such as aerospace vehicles whose design must harmonize a number of subsystems and various physical phenomena, each represented by a separate computer code, e.g., aerodynamics, structures, propulsion, performance, etc. To represent the system internal couplings, the codes receive output from other codes as part of their inputs. The system analysis and optimization task is decomposed into subtasks that can be executed concurrently, each subtask conducted using local state and design variables and holding constant a set of the system-level design variables. The subtasks results are stored in form of the Response Surfaces (RS) fitted in the space of the system-level variables to be used as the subtask surrogates in a system-level optimization whose purpose is to optimize the system objective(s) and to reconcile the system internal couplings. By virtue of decomposition and execution concurrency, the method enables a broad workfront in organization of an engineering project involving a number of specialty groups that might be geographically dispersed, and it exploits the contemporary computing technology of massively concurrent and distributed processing. The report includes a demonstration test case of supersonic business jet design.

  2. Functional levels of floor surface roughness for the prevention of slips and falls: clean-and-dry and soapsuds-covered wet surfaces.

    Science.gov (United States)

    Kim, In-Ju; Hsiao, Hongwei; Simeonov, Peter

    2013-01-01

    Literature has shown a general trend that slip resistance performance improves with floor surface roughness. However, whether slip resistance properties are linearly correlated with surface topographies of the floors or what roughness levels are required for effective slip resistance performance still remain to be answered. This pilot study aimed to investigate slip resistance properties and identify functional levels of floor surface roughness for practical design applications in reducing the risk of slip and fall incidents. A theory model was proposed to characterize functional levels of surface roughness of floor surfaces by introducing a new concept of three distinctive zones. A series of dynamic friction tests were conducted using 3 shoes and 9 floor specimens under clean-and-dry as well as soapsuds-covered slippery wet environments. The results showed that all the tested floor-shoe combinations provided sufficient slip resistances performance under the clean-and-dry condition. A significant effect of floor type (surface roughness) on dynamic friction coefficient (DFC) was found in the soapsuds-covered wet condition. As compared to the surface roughness effects, the shoe-type effects were relatively small. Under the soapsuds-covered wet condition, floors with 50 μm in Ra roughness scale seemed to represent an upper bound in the functional range of floor surface roughness for slip resistance because further increase of surface roughness provided no additional benefit. A lower bound of the functional range for slip resistance under the soapsuds-covered wet condition was estimated from the requirement of DFC > 0.4 at Ra ≅ 17 μm. Findings from this study may have potential safety implications in the floor surface design for reducing slip and fall hazards. Published by Elsevier Ltd.

  3. EXPERIENCE WITH ROBOTIC LUMЕNIS CO LASER IN ENDOSCOPIC LARYNGEAL SURGERY

    Directory of Open Access Journals (Sweden)

    E. N. Novozhilova

    2014-01-01

    Full Text Available  2 The paper describes the first experience in using robotic CO laser at the Department of Head and Neck Tumors, Moscow City Cancer Hospital Sixty-Two. With advances in endoscopic techniques and anesthesiology, there have been new possibilities of usingdirect (rigid larygoscopy in conjunction with laser systems.The Lumеnis laser assembly consists of three interconnected components: a videocamera, an operating microscope, and directly CO laser. It includes a computer system that sets a program to perform an operation.The heart of the laser system is a scanning Digital Acu Blade micromanipulator. This unique assembly makes itpossible to control the area and depth of incision, to cut intricate shapes in relation to the surface anatomy, and to precisely control ablation and hemostasis. The effect of tissue carbonization during surgery is minimal at the expense of the physical characteristics and different modes of radiation. It is noted that this system allows organ-sparing treatment in cancer patients and their prompt rehabilitation after surgical interventions.

  4. Improving Limit Surface Search Algorithms in RAVEN Using Acceleration Schemes: Level II Milestone

    Energy Technology Data Exchange (ETDEWEB)

    Alfonsi, Andrea [Idaho National Laboratory (INL), Idaho Falls, ID (United States); Rabiti, Cristian [Idaho National Laboratory (INL), Idaho Falls, ID (United States); Mandelli, Diego [Idaho National Laboratory (INL), Idaho Falls, ID (United States); Cogliati, Joshua Joseph [Idaho National Laboratory (INL), Idaho Falls, ID (United States); Sen, Ramazan Sonat [Idaho National Laboratory (INL), Idaho Falls, ID (United States); Smith, Curtis Lee [Idaho National Laboratory (INL), Idaho Falls, ID (United States)

    2015-07-01

    , subject of the analysis. These methodologies are named, in the RAVEN environment, adaptive sampling strategies. These methodologies infer system responses from surrogate models constructed from already existing samples (produced using high fidelity simulations) and suggest the most relevant location (coordinate in the input space) of the next sampling point to be explored in the uncertain/parametric domain. When using those methodologies, it is possible to understand features of the system response with a small number of carefully selected samples. This report focuses on the development and improvement of the limit surface search. The limit surface is an important concept in system reliability analysis. Without going into the details, which will be covered later in the report, the limit surface could be briefly described as an hyper-surface in the system uncertainty/parametric space separating the regions leading to a prescribed system outcome. For example, if the uncertainty/parametric space is the one generated by the reactor power level and the duration of the batteries, the system is a nuclear power plant and the system outcome discriminating variable is the clad failure in a station blackout scenario, then the limit surface separates the combinations of reactor power level and battery duration that lead to clad failure from the ones that do not.

  5. Selection of replacement material for the failed surface level gauge wire in Hanford waste tanks

    International Nuclear Information System (INIS)

    Anantatmula, R.P.; Pitman, S.G.; Lund, A.L.

    1995-10-01

    Surface level gauges fabricated from AISI Type 316 stainless steel (316) wire failed after only a few weeks of operation in underground storage tanks at the Hanford Site. The wire failure was determined to be due to chloride ion assisted corrosion of the 316 wire. Radiation-induced breakdown of the polyvinyl chloride (PVC) riser liners is suspected to be the primary source of the chloride ions. An extensive literature search followed by expert concurrence was undertaken to select a replacement material for the wire. Platinum (Pt)-20 % Iridium (Ir) alloy was selected as the replacement material from tile candidate materials, P-20% Ir, Pt-1O% Rhodium (Rh), Pt-20%Rh and Hastelloy C-22. The selection was made on the basis of the alloy's immunity towards acidic and basic environments as well as its adequate tensile properties in the fully annealed state

  6. Selection of replacement material for the failed surface level gauge wire in Hanford waste tanks

    Energy Technology Data Exchange (ETDEWEB)

    Anantatmula, R.P. [Westinghouse Hanford Co., Richland, WA (United States); Pitman, S.G.; Lund, A.L. [Pacific Northwest Lab., Richland, WA (United States)

    1995-10-01

    Surface level gauges fabricated from AISI Type 316 stainless steel (316) wire failed after only a few weeks of operation in underground storage tanks at the Hanford Site. The wire failure was determined to be due to chloride ion assisted corrosion of the 316 wire. Radiation-induced breakdown of the polyvinyl chloride (PVC) riser liners is suspected to be the primary source of the chloride ions. An extensive literature search followed by expert concurrence was undertaken to select a replacement material for the wire. Platinum (Pt){minus}20 % Iridium (Ir) alloy was selected as the replacement material from tile candidate materials, P-20% Ir, Pt-1O% Rhodium (Rh), Pt-20%Rh and Hastelloy C-22. The selection was made on the basis of the alloy`s immunity towards acidic and basic environments as well as its adequate tensile properties in the fully annealed state.

  7. Facet personality and surface-level diversity as team mental model antecedents: implications for implicit coordination.

    Science.gov (United States)

    Fisher, David M; Bell, Suzanne T; Dierdorff, Erich C; Belohlav, James A

    2012-07-01

    Team mental models (TMMs) have received much attention as important drivers of effective team processes and performance. Less is known about the factors that give rise to these shared cognitive structures. We examined potential antecedents of TMMs, with a specific focus on team composition variables, including various facets of personality and surface-level diversity. Further, we examined implicit coordination as an important outcome of TMMs. Results suggest that team composition in terms of the cooperation facet of agreeableness and racial diversity were significantly related to team-focused TMM similarity. TMM similarity was also positively predictive of implicit coordination, which mediated the relationship between TMM similarity and team performance. Post hoc analyses revealed a significant interaction between the trust facet of agreeableness and racial diversity in predicting TMM similarity. Results are discussed in terms of facilitating the emergence of TMMs and corresponding implications for team-related human resource practices. (PsycINFO Database Record (c) 2012 APA, all rights reserved).

  8. Ab initio potential energy surface and vibration-rotation energy levels of beryllium monohydroxide.

    Science.gov (United States)

    Koput, Jacek

    2017-01-05

    The accurate potential energy surface of beryllium monohydroxide, BeOH, in its ground electronic state X 2A' has been determined from ab initio calculations using the coupled-cluster approach in conjunction with the correlation-consistent core-valence basis sets up to septuple-zeta quality. The higher-order electron correlation, scalar relativistic, and adiabatic effects were taken into account. The BeOH molecule was confirmed to be bent at equilibrium, with the BeOH angle of 141.2° and the barrier to linearity of 129 cm -1 . The vibration-rotation energy levels of the BeOH and BeOD isotopologues were predicted using a variational approach and compared with recent experimental data. The results can be useful in a further analysis of high-resolution vibration-rotation spectra of these interesting species. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  9. Ab initio potential energy surface and vibration-rotation energy levels of sulfur dioxide.

    Science.gov (United States)

    Koput, Jacek

    2017-05-05

    An accurate potential energy surface of sulfur dioxide, SO 2 , in its ground electronic state X∼ 1A1 has been determined from ab initio calculations using the coupled-cluster approach in conjunction with the correlation-consistent basis sets up to septuple-zeta quality. The results obtained with the conventional and explicitly correlated coupled-cluster methods are compared. The role of the core-electron correlation, higher-order valence-electron correlation, scalar relativistic, and adiabatic effects in determining the structure and dynamics of the SO 2 molecule is discussed. The vibration-rotation energy levels of the 32 SO 2 and 34 SO 2 isotopologues were predicted using a variational approach. It was shown that the inclusion of the aforementioned effects was mandatory to attain the "spectroscopic" accuracy. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  10. Modification of backfill material used in near surface disposal of low-level radwaste

    International Nuclear Information System (INIS)

    Gu Cunli; Liu Zhen; Fan Zhiwen; Xie Jianxun; Huang Yawen

    1993-01-01

    Clay has the merits of good airtightness and strong anti-permeability when it is used as backfill material in near-surface disposal of low-level radwaste, though its ion exchange capacity is not large. In order to increase its ability to retard nuclides, 9 kinds of 5 categories of additives have been used in the test for its modification. The results show that the anti-permeability of the mixed material decreases unnoticeably, while the distribution coefficients (K d ) for 60 Co, 134 Cs and 85 Sr are 4.8, 4.6, and 4.7 times that using pure clay respectively, when the amount of Ca-bentonite added is 10%. The migration of 60 Co, 134 Cs, and 85 Sr in the clay of different densities under dynamic conditions has been studied, and the retardation factor Rd, obtained

  11. Energy pumping analysis of skating motion in a half pipe and on a level surface

    International Nuclear Information System (INIS)

    Feng, Z C; Xin, Ming

    2015-01-01

    In this paper, an energy pumping mechanism for locomotion is analysed. The pumping is accomplished by exerting forces perpendicular to the direction of motion. The paper attempts to demonstrate an interesting application of the classical mechanics to two sporting events: a person skating in a half pipe and a person travelling on a level surface on a skateboard. The equations of motion based on simplified mechanical models are derived using the Lagrange mechanics. The energy-pumping phenomenon is revealed through numerical simulations with simple pumping actions. The result presented in this paper can be used as an interesting class project in undergraduate mechanics or physics courses. It also motivates potential new applications of energy pumping in many engineering fields. (paper)

  12. Low level chemiluminescence measurement of the binding of 8-methoxypsoralen to proteins and lymphocytic surfaces

    International Nuclear Information System (INIS)

    Lange, B.

    1980-01-01

    Photochemotherapy with 8-methoxypsoralen (8-MOP) and longwave ultraviolet light is beneficial in such different disorders like psoriasis, lichen planus, and mykosis fungoides. In contrast to a widely accepted hypothesis 8-MOP does not solely bind to nucleic acid, but also to certain proteins. The mechanism of this binding as well as the precise binding area are unknown. Therefore the UV-provoked reactions of 8-MOP with a lipid mixture, a glucosaminoglycan solution, a protein solution, and lymphocyte suspensions, respectively were investigated using low level chemiluminescence (LLCL). It was found an 8-MOP concentration-dependent decrease of LLCL intensity in the lymphocyte suspensions (10 3 to 10 4 cells/μl). This effect is result of the diminution of the photoactive 8-MOP content of the solution. 8-MOP binds quickly and in the course of a free radical reaction to lymphocytic surfaces and coincidentally loses its potency to start LLCL-detectable free radical chain responses. (author)

  13. Using the level set method in geodynamical modeling of multi-material flows and Earth's free surface

    NARCIS (Netherlands)

    Hillebrand, B.; Thieulot, C.; Geenen, T.; Van Den Berg, A. P.; Spakman, W.

    2014-01-01

    The level set method allows for tracking material surfaces in 2-D and 3-D flow modeling and is well suited for applications of multi-material flow modeling. The level set method utilizes smooth level set functions to define material interfaces, which makes the method stable and free of oscillations

  14. Environmental biotechnology for the eco-efficient decontamination of petroleum hydrocarbon polluted sites in the NIS

    International Nuclear Information System (INIS)

    Kerstin, S.; Andreas, P. L.; Hildegard, A.

    2005-01-01

    Full text : Pollution of soil and ground water with petroleum hydrocarbons is a major environmental problem in many oil producing regions of the New Independent States. Decontamination of these areas using conventional technologies based on physical, chemical and / or thermal pollutant removal would require major financial resources and represent a great economical burden for these regions. Thus, contaminated land management (CLM) has to focus on efficient yet low-cost strategies yielding the optimum ecological outcome. Approaching such eco-efficient, i.e ecologically sound and economically feasible solutions includes the consideration of technical, scientific and socio-economic aspects. A comprehensive risk assessment states the basis for these CLM strategies, which considers both technical (e.g. soil type, groundwater characteristics) and regional aspects (e.g. demographic and socio-economic details). This requires a holistic understanding of these capacious problems and its communication to and the involvement of the stakeholders. Such eco-efficient technologies that are suitable for the clean-up of soils and aquifers polluted with organic chemicals (e.g. crude oil and its derivatives) are offered by environmental biotechnology. Decontamination techniques such as bioremediation, based on the engineered promotion of the soil's intrinsic microbiological capability to recover from environmental stresses, are fit to re-establish acceptable environmental conditions on a reasonable time-scale while requiring comparably little resources. Bioremediation techniques may be applied after excavation of the polluted soil (ex situ) or on the site as is, leaving contaminated material in place (in situ). Surface, ex situ, treatment (biopiles, landfarming) facilitates the homogenous addition of additives such as surfactants, nutrients or pollutant degrading microorganisms. By contrast, in situ technologies (e.g. bioventing, biosparging) are, as they do not require soil

  15. Assessment of the SMAP Level-4 Surface and Root-Zone Soil Moisture Product Using In Situ Measurements

    NARCIS (Netherlands)

    Reichle, Rolf H.; De Lannoy, Gabrielle J. M.; Liu, Qing; Ardizzone, Joseph V.; Colliander, Andreas; Conaty, Austin; Crow, Wade; Jackson, Thomas J.; Jones, Lucas A.; Kimball, John S.; Koster, Randal D.; Mahanama, Sarith P.; Smith, Edmond B.; Berg, Aaron; Bircher, Simone; Bosch, David; Caldwell, Todd G.; Cosh, Michael; Holifield Collins, Chandra D.; Jensen, Karsten H.; Livingston, Stan; Lopez-baeza, Ernesto; Martínez-fernández, José; Mcnairn, Heather; Moghaddam, Mahta; Pacheco, Anna; Pellarin, Thierry; Prueger, John; Rowlandson, Tracy; Seyfried, Mark; Starks, Patrick; Su, Bob; Thibeault, Marc; Van Der Velde, Rogier; Walker, Jeffrey; Wu, Xiaoling; Zeng, Yijian

    2017-01-01

    The Soil Moisture Active Passive (SMAP) mission Level-4 Surface and Root-Zone Soil Moisture (L4_SM) data product is generated by assimilating SMAP L-band brightness temperature observations into the NASA Catchment land surface model. The L4_SM product is available from 31 March 2015 to present

  16. Level-one and -two SU(2) Wess-Zumino model on higher-genus Riemann surfaces

    International Nuclear Information System (INIS)

    Malik, R.P.; Behera, N.; Kaul, R.K.

    1991-01-01

    Level-one and -two SU(2) Wess-Zumino models are studied on higher-genus Riemann surfaces. Factorization properties under zero- and non-zero-homology pinching limits and modular invariance are exploited to ensure the correctness of correlators and characters of these models on any arbitrary-genus Riemann surfaces

  17. Prediction of protein retention times in hydrophobic interaction chromatography by robust statistical characterization of their atomic-level surface properties.

    NARCIS (Netherlands)

    Hanke, A.T.; Klijn, M.E.; Verhaert, P.D.; Wielen, van der L.; Ottens, M.; Eppink, M.H.M.; Sandt, van de E.J.A.X.

    2016-01-01

    The correlation between the dimensionless retention times (DRT) of proteins in hydrophobic interaction chromatography (HIC) and their surface properties were investigated. A ternary atomic-level hydrophobicity scale was used to calculate the distribution of local average hydrophobicity across the

  18. OMI/Aura Surface Reflectance Climatology Level 3 Global 0.5deg Lat/Lon Grid V003

    Data.gov (United States)

    National Aeronautics and Space Administration — The OMI Earth Surface Reflectance Climatology product, OMLER (Global 0.5deg Lat/Lon grid) which is based on Version 003 Level-1B top of atmosphere upwelling radiance...

  19. A Continuous Liquid-Level Sensor for Fuel Tanks Based on Surface Plasmon Resonance

    Directory of Open Access Journals (Sweden)

    Antonio M. Pozo

    2016-05-01

    Full Text Available A standard problem in large tanks at oil refineries and petrol stations is that water and fuel usually occupy the same tank. This is undesirable and causes problems such as corrosion in the tanks. Normally, the water level in tanks is unknown, with the problems that this entails. We propose herein a method based on surface plasmon resonance (SPR to detect in real time the interfaces in a tank which can simultaneously contain water, gasoline (or diesel and air. The plasmonic sensor is composed of a hemispherical glass prism, a magnesium fluoride layer, and a gold layer. We have optimized the structural parameters of the sensor from the theoretical modeling of the reflectance curve. The sensor detects water-fuel and fuel-air interfaces and measures the level of each liquid in real time. This sensor is recommended for inflammable liquids because inside the tank there are no electrical or electronic signals which could cause explosions. The sensor proposed has a sensitivity of between 1.2 and 3.5 RIU−1 and a resolution of between 5.7 × 10−4 and 16.5 × 10−4 RIU.

  20. Genus- and species-level identification of dermatophyte fungi by surface-enhanced Raman spectroscopy

    Science.gov (United States)

    Witkowska, Evelin; Jagielski, Tomasz; Kamińska, Agnieszka

    2018-03-01

    This paper demonstrates that surface-enhanced Raman spectroscopy (SERS) coupled with principal component analysis (PCA) can serve as a fast and reliable technique for detection and identification of dermatophyte fungi at both genus and species level. Dermatophyte infections are the most common mycotic diseases worldwide, affecting a quarter of the human population. Currently, there is no optimal method for detection and identification of fungal diseases, as each has certain limitations. Here, for the first time, we have achieved with a high accuracy, differentiation of dermatophytes representing three major genera, i.e. Trichophyton, Microsporum, and Epidermophyton. Two first principal components (PC), namely PC-1 and PC-2, gave together 97% of total variance. Additionally, species-level identification within the Trichophyton genus has been performed. PC-1 and PC-2, which are the most diagnostically significant, explain 98% of the variance in the data obtained from spectra of: Trichophyton rubrum, Trichophyton menatgrophytes, Trichophyton interdigitale and Trichophyton tonsurans. This study offers a new diagnostic approach for the identification of dermatophytes. Being fast, reliable and cost-effective, it has the potential to be incorporated in the clinical practice to improve diagnostics of medically important fungi.

  1. The association between amalgam dental surfaces and urinary mercury levels in a sample of Albertans, a prevalence study.

    Science.gov (United States)

    Dutton, Daniel J; Fyie, Ken; Faris, Peter; Brunel, Ludovic; Emery, Jc Herbert

    2013-08-29

    The objective of this study was to quantify the relationship between number of dental amalgam surfaces and urinary mercury levels. This study uses participant data from a large philanthropic chronic disease prevention program in Calgary, Alberta, Canada. Urine samples were analysed for mercury levels (measured in μg/g-creatinine). T-tests were used to determine if differences in urine mercury were statistically significant between persons with no dental amalgam surfaces and one or more dental amalgam surfaces. Linear regression was used to estimate the change in urinary mercury per amalgam surface. Urinary mercury levels were statistically significantly higher in participants with amalgam surfaces, with an average difference of 0.55 μg/g-creatinine. Per amalgam surface, we estimated an expected increase of 0.04 μg/g-creatinine. Measured urinary mercury levels were also statistically significantly higher in participants with dental amalgam surfaces following the oral administration of 2,3-dimercaptopropane-l-sulfonate (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA) which are used to mobilize mercury from the blood and tissues. Our estimates indicate that an individual with seven or more dental amalgam surfaces has 30% to 50% higher urinary mercury levels than an individual without amalgams. This is consistent with past literature that has identified seven amalgam surfaces as an unsafe level of exposure to mercury vapor. Our analysis suggests that continued use of silver amalgam dental fillings for restorative dentistry is a non-negligible, unnecessary source of mercury exposure considering the availability of composite resin alternatives.

  2. The association between amalgam dental surfaces and urinary mercury levels in a sample of Albertans, a prevalence study

    Science.gov (United States)

    2013-01-01

    Objective The objective of this study was to quantify the relationship between number of dental amalgam surfaces and urinary mercury levels. Methods This study uses participant data from a large philanthropic chronic disease prevention program in Calgary, Alberta, Canada. Urine samples were analysed for mercury levels (measured in μg/g-creatinine). T-tests were used to determine if differences in urine mercury were statistically significant between persons with no dental amalgam surfaces and one or more dental amalgam surfaces. Linear regression was used to estimate the change in urinary mercury per amalgam surface. Results Urinary mercury levels were statistically significantly higher in participants with amalgam surfaces, with an average difference of 0.55 μg/g-creatinine. Per amalgam surface, we estimated an expected increase of 0.04 μg/g-creatinine. Measured urinary mercury levels were also statistically significantly higher in participants with dental amalgam surfaces following the oral administration of 2,3-dimercaptopropane-l-sulfonate (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA) which are used to mobilize mercury from the blood and tissues. Discussion Our estimates indicate that an individual with seven or more dental amalgam surfaces has 30% to 50% higher urinary mercury levels than an individual without amalgams. This is consistent with past literature that has identified seven amalgam surfaces as an unsafe level of exposure to mercury vapor. Our analysis suggests that continued use of silver amalgam dental fillings for restorative dentistry is a non-negligible, unnecessary source of mercury exposure considering the availability of composite resin alternatives. PMID:23984857

  3. Molecular and structural characterisation of the human sodium/iodide symporter (h N.I.S.) C-terminus and the implication of this domain in the transporter regulation

    International Nuclear Information System (INIS)

    Huc, S.

    2007-12-01

    The human natrium iodide symporter (h N.I.S.) is an intrinsic membrane protein expressed in thyroid cells where it allows iodide uptake and accumulation. It is composed of thirteen transmembrane helices and its ninety- three amino acids long cytosolic C-terminus presents many potential post-translational regulatory sites. A first part of the PhD work has been dedicated to the expression in a bacterial system and to the purification of the cytosolic C-terminal fragment. Biochemical and structural characterisation have revealed that this C-terminus is very flexible but prone to dimerization. The fragment has also been used as a bait to test the interactions with PDZ domain proteins spotted on a membrane. Several proteins interacting with the (natrium/iodide symporter) N.I.S. C-terminus have thus been identified and the study of their implication in the protein regulation has been initiated. A second part of the work has underlined the existence of a N.I.S. fragment co-purified with the entire protein. This fragment has been found in cells in culture stably expressing N.I.S. and also in human thyroid extracts and in rodent thyroid cells. We observed that this fragment is spontaneously associated with the entire protein. It is composed of the last 131 amino acid of the protein and so comprises the last transmembrane domain and the C-terminal extremity. The expression of a truncated form of h N.I.S., lacking the last 131 amino acids, shows that this protein is not correctly addressed to the cell membrane and cells expressing this mutated symporter cannot accumulate iodide. However, our results show that the co-expression of the two N.I.S. parts, the truncated form lacking the last 131 amino acid, and the complementary C-terminal fragment, leads to cells presenting 10 % of the activity of cells expressing the whole N.I.S.. (author)

  4. Investigation of siting parameters for near surface disposal of low-level nuclear waste. Final report

    International Nuclear Information System (INIS)

    Schell, W.R.; Sanchez, A.L.; Thomas, E.D.

    1985-01-01

    A study was initiated in April 1984 to evaluate actual problems associated with and to recommend improvements for near surface disposal of low-level radioactive wastes in the State of Pennsylvania and the humid Northeast. The results of field measurements showed some vertical transport of 137 Cs and other fallout radionuclides in 210 Pb dated peat cores from the unsaturated zone. Under the natural acid rain conditions (pH 4.0), the most mobile radionuclide, 137 Cs, gave diffusion coefficients of 10 -7 to 10 -9 cm 2 /sec in the different organic rich soils. Both the upward and downward migration of radionuclides resulted from the hydrological cycle of evapotranspiration and precipitation which gave diffusive mixing of mobile radionuclides. The distribution coefficient, K/sub d/ values, for several radionuclides in the organic rich soils were found to be equal to or greater than those measured previously for inorganic clay and sediment matrices. To insure that radionuclides do not enter water supplies in the humid Northeast where pH 4.0 rain is encountered, a peat liner should be considered in the multibarrier design of repositories. 32 refs., 16 figs., 8 tabs

  5. Formation of halo-structures in oxygen isotopes through change of occupancy of levels near Fermi surface

    International Nuclear Information System (INIS)

    Bhattacharya, Rupayan

    2000-01-01

    Recently a new parametrisation of Skyrme interaction has been formulated in order to study the level inversions of A=9 isobars. The role of occupancy of 2s 1/2 level in determining the halo structures of O, N, C, B and Be nuclei was shown. A thorough investigation on the binding energies, rms charge, neutron and matter distribution and occupation probabilities of levels near the Fermi surface has been done in the present work

  6. Interpreting Changes in Surface EMG Amplitude During High-Level Fatiguing Contractions of the Brachioradialis

    National Research Council Canada - National Science Library

    Lowery, M

    2001-01-01

    ... to estimate muscle fatigue. In this paper, theoretical relationships between surface EMG amplitude measures and mean motor unit firing rates and muscle fiber conduction velocity (MFCV) are established...

  7. Impacts of Future Climate Change and Baltic Sea Level Rise on Groundwater Recharge, Groundwater Levels, and Surface Leakage in the Hanko Aquifer in Southern Finland

    Directory of Open Access Journals (Sweden)

    Samrit Luoma

    2014-11-01

    Full Text Available The impact of climate change and Baltic Sea level rise on groundwater resources in a shallow, unconfined, low-lying coastal aquifer in Hanko, southern Finland, was assessed using the UZF1 model package coupled with the three-dimensional groundwater flow model MODFLOW to simulate flow from the unsaturated zone through the aquifer. The snow and PET models were used to calculate the surface water availability for infiltration from the precipitation data used in UZF1. Infiltration rate, flow in the unsaturated zone and groundwater recharge were then simulated using UZF1. The simulation data from climate and sea level rise scenarios were compared with present data. The results indicated changes in recharge pattern during 2071–2100, with recharge occurring earlier in winter and early spring. The seasonal impacts of climate change on groundwater recharge were more significant, with surface overflow resulting in flooding during winter and early spring and drought during summer. Rising sea level would cause some parts of the aquifer to be under sea level, compromising groundwater quality due to intrusion of sea water. This, together with increased groundwater recharge, would raise groundwater levels and consequently contribute more surface leakage and potential flooding in the low-lying aquifer.

  8. Analysis of turbulence and surface growth models on the estimation of soot level in ethylene non-premixed flames

    Science.gov (United States)

    Yunardi, Y.; Munawar, Edi; Rinaldi, Wahyu; Razali, Asbar; Iskandar, Elwina; Fairweather, M.

    2018-02-01

    Soot prediction in a combustion system has become a subject of attention, as many factors influence its accuracy. An accurate temperature prediction will likely yield better soot predictions, since the inception, growth and destruction of the soot are affected by the temperature. This paper reported the study on the influences of turbulence closure and surface growth models on the prediction of soot levels in turbulent flames. The results demonstrated that a substantial distinction was observed in terms of temperature predictions derived using the k-ɛ and the Reynolds stress models, for the two ethylene flames studied here amongst the four types of surface growth rate model investigated, the assumption of the soot surface growth rate proportional to the particle number density, but independent on the surface area of soot particles, f ( A s ) = ρ N s , yields in closest agreement with the radial data. Without any adjustment to the constants in the surface growth term, other approaches where the surface growth directly proportional to the surface area and square root of surface area, f ( A s ) = A s and f ( A s ) = √ A s , result in an under- prediction of soot volume fraction. These results suggest that predictions of soot volume fraction are sensitive to the modelling of surface growth.

  9. One-level modeling for diagnosing surface winds over complex terrain. II - Applicability to short-range forecasting

    Science.gov (United States)

    Alpert, P.; Getenio, B.; Zak-Rosenthal, R.

    1988-01-01

    The Alpert and Getenio (1988) modification of the Mass and Dempsey (1985) one-level sigma-surface model was used to study four synoptic events that included two winter cases (a Cyprus low and a Siberian high) and two summer cases. Results of statistical verification showed that the model is not only capable of diagnosing many details of surface mesoscale flow, but might also be useful for various applications which require operative short-range prediction of the diurnal changes of high-resolution surface flow over complex terrain, for example, in locating wildland fires, determining the dispersion of air pollutants, and predicting changes in wind energy or of surface wind for low-level air flights.

  10. Urbanization increased metal levels in lake surface sediment and catchment topsoil of waterscape parks

    Energy Technology Data Exchange (ETDEWEB)

    Li, Hong-Bo [Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021 (China); Graduate University of Chinese Academy of Sciences, Beijing 100049 (China); Yu, Shen, E-mail: syu@iue.ac.cn [Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021 (China); Li, Gui-Lin [Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021 (China); Liu, Yi; Yu, Guang-Bin [Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021 (China); Graduate University of Chinese Academy of Sciences, Beijing 100049 (China); Deng, Hong [Department of Environmental Sciences, Tiantong National Station of Forest Ecosystem, Key Laboratory of Urbanization and Ecological Restoration, East China Normal University, Shanghai 200062 (China); Wu, Sheng-Chun [State Key Laboratory in Marine Pollution, Biology and Chemistry Department, City University of Hong Kong, Hong Kong (China); Wong, Ming-Hung [Croucher Institute for Environmental Sciences, Hong Kong Baptist University, Hong Kong (China)

    2012-08-15

    Lake surface sediment is mainly derived from topsoil in its catchment. We hypothesized that distribution of anthropogenic metals would be homogenous in lake surface sediment and the lake's catchment topsoil. Anthropogenic metal distributions (cadmium (Cd), copper (Cu), lead (Pb), and zinc (Zn)) in fourteen waterscape parks were investigated in surface sediments and catchment topsoils and possible source homogeneity was tested using stable Pb isotopic ratio analysis. The parks were located along an urbanization gradient consisting of suburban (SU), developing urban (DIU), developed urban (DDU), and central urban core (CUC) areas in Shanghai, China. Results indicated that surface lake sediments and catchment topsoils in the CUC parks were highly contaminated by the investigated anthropogenic metals. Total metal contents in surface sediment and topsoil gradually increased along the urbanization gradient from the SU to CUC areas. Generally, the surface sediments had greater total metal contents than their catchment topsoils. These results suggest that urbanization drives the anthropogenic metal enrichment in both surface sediment and its catchment topsoil in the waterscape parks. Soil fine particles (< 63 {mu}m) and surface sediments had similar enrichment ratios of metals, suggesting that surface runoff might act as a carrier for metals transporting from catchment to lake. Stable Pb isotope ratio analysis revealed that the major anthropogenic Pb source in surface sediment was coal combustion as in the catchment topsoil. Urbanization also correlated with chemical fractionation of metals in both surface sediment and catchment topsoil. From the SU to the CUC parks, amounts of labile metal fractions increased while the residual fraction of those metals remained rather constant. In short, urbanization in Shanghai drives anthropogenic metal distribution in environmental matrices and the sources were homogenous. -- Highlights: Black-Right-Pointing-Pointer Obvious

  11. Urbanization increased metal levels in lake surface sediment and catchment topsoil of waterscape parks

    International Nuclear Information System (INIS)

    Li, Hong-Bo; Yu, Shen; Li, Gui-Lin; Liu, Yi; Yu, Guang-Bin; Deng, Hong; Wu, Sheng-Chun; Wong, Ming-Hung

    2012-01-01

    Lake surface sediment is mainly derived from topsoil in its catchment. We hypothesized that distribution of anthropogenic metals would be homogenous in lake surface sediment and the lake's catchment topsoil. Anthropogenic metal distributions (cadmium (Cd), copper (Cu), lead (Pb), and zinc (Zn)) in fourteen waterscape parks were investigated in surface sediments and catchment topsoils and possible source homogeneity was tested using stable Pb isotopic ratio analysis. The parks were located along an urbanization gradient consisting of suburban (SU), developing urban (DIU), developed urban (DDU), and central urban core (CUC) areas in Shanghai, China. Results indicated that surface lake sediments and catchment topsoils in the CUC parks were highly contaminated by the investigated anthropogenic metals. Total metal contents in surface sediment and topsoil gradually increased along the urbanization gradient from the SU to CUC areas. Generally, the surface sediments had greater total metal contents than their catchment topsoils. These results suggest that urbanization drives the anthropogenic metal enrichment in both surface sediment and its catchment topsoil in the waterscape parks. Soil fine particles (< 63 μm) and surface sediments had similar enrichment ratios of metals, suggesting that surface runoff might act as a carrier for metals transporting from catchment to lake. Stable Pb isotope ratio analysis revealed that the major anthropogenic Pb source in surface sediment was coal combustion as in the catchment topsoil. Urbanization also correlated with chemical fractionation of metals in both surface sediment and catchment topsoil. From the SU to the CUC parks, amounts of labile metal fractions increased while the residual fraction of those metals remained rather constant. In short, urbanization in Shanghai drives anthropogenic metal distribution in environmental matrices and the sources were homogenous. -- Highlights: ► Obvious urbanization effect on metal

  12. Radionuclide transport modelling for a buried near surface low level radioactive waste

    International Nuclear Information System (INIS)

    Terzi, R.

    2004-01-01

    The disposal of radioactive waste, which is the last step of any radioactive waste management policy, has not yet been developed in Turkey. The existing legislation states only the discharge limits for the radioactive wastes to be discharged to the environment. The objective of this modelling study is to assist in safety assessment and selecting disposal site for gradually increasing non-nuclear radioactive wastes. This mathematical model has been developed for the environmental radiological assessment of near surface disposal sites for the low and intermediate level radioactive wastes. The model comprised of three main components: source term, geosphere transport and radiological assessment. Radiation dose for the babies (1 years age) and adults (≥17 years age) have been computed for the radionuclides Cesium 137 (Cs-137) and Strontium 90 (Sr-90), having the activity of 1.10 12 Becquerel(Bq), in radioactive waste through transport of radionuclide in liquid phase with the various pathways. The model consisted of first order ordinary differential equations was coded as a TCODE file in MATLAB program. The radiation dose to man for the realist case and low probability case have been calculated by using Runge-Kutta solution method in MATLAB programme for radionuclide transport from repository to soil layer and then to the ground water(saturated zone) through drinking water directly and consuming agricultural and animal products pathways in one year period. Also, the fatal cancer risk assessment has been made by taking into account the annual dose received by people. Various dose values for both radionuclides have been found which depended on distribution coefficient, retardation factor and dose conversion factors. The most important critical parameters on radiological safety assessment are the distribution coefficient in soil layer, seepage velocity in unsaturated zone and thickness of the unsaturated zone (soil zone). The highest radiation dose and average dose to

  13. Multiconfiguration Pair-Density Functional Theory and Complete Active Space Second Order Perturbation Theory. Bond Dissociation Energies of FeC, NiC, FeS, NiS, FeSe, and NiSe.

    Science.gov (United States)

    Sharkas, Kamal; Gagliardi, Laura; Truhlar, Donald G

    2017-12-07

    We investigate the performance of multiconfiguration pair-density functional theory (MC-PDFT) and complete active space second-order perturbation theory for computing the bond dissociation energies of the diatomic molecules FeC, NiC, FeS, NiS, FeSe, and NiSe, for which accurate experimental data have become recently available [Matthew, D. J.; Tieu, E.; Morse, M. D. J. Chem. Phys. 2017, 146, 144310-144320]. We use three correlated participating orbital (CPO) schemes (nominal, moderate, and extended) to define the active spaces, and we consider both the complete active space (CAS) and the separated-pair (SP) schemes to specify the configurations included for a given active space. We found that the moderate SP-PDFT scheme with the tPBE on-top density functional has the smallest mean unsigned error (MUE) of the methods considered. This level of theory provides a balanced treatment of the static and dynamic correlation energies for the studied systems. This is encouraging because the method is low in cost even for much more complicated systems.

  14. Core-level spectroscopic study of the evolution of the sulfur-passivated InP(001) surface during annealing

    International Nuclear Information System (INIS)

    Tian, Z.; Dharma-wardana, M.W.; Lu, Z.H.; Cao, R.; Lewis, L.J.

    1997-01-01

    Core-level photoemission spectroscopy and theoretical predictions of structure and spectra are used to study the fully S-covered InP(001) surface and its evolution during annealing. The theory predicts a number of stable structures besides the lowest-energy ground state which is the fully S-covered (2x2)-reconstructed structure, where the surface has two types of S atoms. On annealing, a fascinating sequence of structures unfolds from the fully S-covered ground state as the other stable structures become energetically accessible. The surface S atoms exchange with bulk P atoms on annealing, forming new strong S endash P bonds while dissociating preexisting S endash S dimers. The S endash P bonds are tilted with the P atoms just above the surface and there is only one type of S atom in the structure. The measured excitation energies and spectra agree with theoretical predictions of the core-level spectra for the (2x2) reconstruction and its evolution to partial S coverages. We conclude that the annealed surface around 700 K is most likely to be a (2x2) reconstructed surface with the surface cell containing two S endash P bonds, with just one type of S atom. copyright 1997 The American Physical Society

  15. What really separates us? Survey of attitudes of young people in the cities of Kikinda (Vojvodina, Nis, Bor (South and East Serbia, and Pristina, Pec, Prizren (Kosovo

    Directory of Open Access Journals (Sweden)

    Bašić Goran

    2014-01-01

    Full Text Available The results of the survey point to a high level of agreement among youth aged between 15 and 25 years of age, high school and college students, employed and unemployed youth, men and women in the cities of Pec, Pristina, Prizren in Kosovo, and Bor, Kikinda, and Nis in Serbia, on whether the question of mutual cooperation is burdened by prejudice and events from the past, and that the possibility and the quality of cooperation is influenced by the attitudes the receive in their primary social groups such as families and peers, and also by the attitudes they receive through education and media. At the same time, the possibilities to influence the social and political change aren’t big, and the youth have no desire to take the concrete civic or political initiatives. A certain perspective in cooperation the youth see in the European constellation and the good quality education. However, youth on both sides are not open to more intensive mutual meetings - the majority would not either host peers from the other communities gladly, nor they would respond to their invitation of hosting. They are not interested in cultural values of one another, but they do think respect of human rights should be guaranteed and they are ready for toleration of differences. The necessity of youth cooperation is important for overcoming the problems that citizens of Kosovo and Serbia are facing when it comes to exercising numerous rights, which from the perspective of individual freedoms collide with the concept of state reasons and "higher" interests. The regional stability depends on overcoming the issues that governments in Serbia and Kosovo have concerning Kosovo’s status, and also from setting a network of individual and group relations among the citizens. Youth should be the carriers of social and cultural changes. In the stated attitudes there is no direct objection to such processes, but fear of changes is clearly expressed because indirectly it can be

  16. Abdominal strengthening using the AbVice machine as measured by surface electromyographic activation levels.

    Science.gov (United States)

    Avedisian, Lori; Kowalsky, Don S; Albro, Richard C; Goldner, Daniel; Gill, Robert C

    2005-08-01

    Twenty-four college students served as subjects in a study that examined the effect of a prototypical abdominal muscle strengthening device (AbVice) compared with other devices currently on the market. The purpose of the present study was to investigate a prototypical device (AbVice) that incorporates contraction of the hamstring and gluteal musculature in conjunction with the abdominals, which may assist in decreasing activation of the hip flexors by allowing greater activity levels of the abdominal musculature via the theory of reflex inhibition, compared with other devices currently available on the market (AbRoller and AbRocker). The repeated-measures study included 17 women and 7 men who ranged in age from 20-23 years (mean +/- SD age, 21.3 +/- 1.5 years). Each subject underwent a single session of data collection during which they completed 10 repetitions of abdominal crunches per device. Subjects completed 4 different crunch sets (AbRocker, AbRoller, standard crunch, AbVice). Counterbalancing of the device was used to negate the effect of fatigue. Speed of repetitions was ensured via use of a metronome set at 40 b.min(-1) to permit similar contraction times and rest periods between repetitions. Rest between conditions was 3 minutes. Mean activation levels of surface electromyography (EMG) were recorded for each condition at the following locations on the right side of the body: rectus abdominis 2.5 cm superior to the umbilicus, rectus abdominis 2.5 cm inferior to the umbilicus, external oblique abdominis 1.0 cm medial to the anterior superior iliac spine, and external oblique abdominis less than 1.0 cm superior to the inguinal ligament. Mean (SD) activation was 1,165.21 mV (634.60 mV) with the AbVice, 242.92 mV (263.03 mV) with the AbRocker, 753.29 mV (514.80 mV) with the standard crunch, and 757.67 mV (542.85 mV) with the AbRoller. Broken down by sex, women had the following mean (SD) EMG values: 1,079.76 mV (705.02 mV) with the AbVice, 680.35 mV (535.35 m

  17. Main results of ten years co-operation with Nis in the field of physical protection of nuclear materials and nuclear facilities

    International Nuclear Information System (INIS)

    Salewski, P.; Gutschmidt, W.

    2001-01-01

    The Federal Republic of Germany (FRG), the Russian Federation (RF) and the New Independent States (NIS) have been working closely together since 1992 in the field of physical protection. The success of this co-operative work is based on mutually beneficial agreements between corresponding FRG and RF ministries. The main working points of these agreements were a) a mutual exchange of information and experience, and b) assistance in developing licensing and regulatory procedures and guidelines, and c) physical upgrades to Russian nuclear facilities. The first two points have been established by holding seminars, workshops and by on-site instruction. Upgrades of RF nuclear installations, financed by the FRG were performed at: the Bochvar Institute in Moscow, the Kurchatov Institute in Moscow and the Mayak reactor plant in Chelyabinsk. This paper will outline the progress made to date and the GRS procedure for achieving successful co-operation with its RF and NIS counterparts. The major results of ten years cooperation will be shown. The following document describes the experiences gained during the evaluation of security reports by GRS as an external expert organisation in contract with the Supervisory Authorities. (authors)

  18. Water transport by Na+-coupled cotransporters of glucose (SGLT1) and of iodide (NIS). The dependence of substrate size studied at high resolution

    DEFF Research Database (Denmark)

    Zeuthen, Thomas; Belhage, Bo; Zeuthen, Emil

    2005-01-01

    -analogue alpha-MDG (MW 194); using the larger sugar arbutin (MW 272) this number was reduced by a factor of at least 0.86+/-0.03 (15). For the human SGLT1 the respective numbers were 234+/-12 (18) and 0.85+/-0.8 (7). For NIS, 253+/-16 (12) water molecules were cotransported for each 2 Na+ and 1 thiocyanate (SCN......The relation between substrate and water transport was studied in Na+-coupled cotransporters of glucose (SGLT1) and of iodide (NIS) expressed in Xenopus oocytes. The water transport was monitored from changes in oocyte volume at a resolution of 20 pl, more than one order of magnitude better than...... of cotransport was changed by isosmotic application of substrate, by rapid changes in clamp voltage, or by poisoning. Transport of larger substrates gave rise to less water transport. For the rabbit SGLT1, 378+/-20 (n=18 oocytes) water molecules were cotransported along with the 2 Na+ ions and the glucose...

  19. BRAF V600E and decreased NIS and TPO expression are associated with aggressiveness of a subgroup of papillary thyroid microcarcinoma.

    Science.gov (United States)

    Bastos, André Uchimura; Oler, Gisele; Nozima, Bruno Heidi Nakano; Moysés, Raquel Ajub; Cerutti, Janete Maria

    2015-10-01

    Thyroid cancer incidence has dramatically increased worldwide over the last two decades. The rise is mostly due to an increased detection of small papillary thyroid carcinomas (PTCs) (≤20  mm), predominantly microPTC (≤10  mm). Although small tumors generally have an excellent outcome, a considerable percentage may have a more aggressive disease and worse prognosis. The clinical challenge is to preoperatively identify those tumors that are more likely to recur. To improve risk stratification and patient management, we sought to determine the prognostic value of BRAF V600E, NRAS or RET/PTC mutations in patients with PTC measuring TPO, TG, TSHR and PDS) and correlated with clinico-pathological findings that are predictors of recurrence. This study shows that tumors measuring ≤20  mm exhibited higher prevalence of BRAF V600E mutation, which correlated with aggressive histopathological parameters, higher risk of recurrence, and lower expression of NIS and TPO. Although this correlation was not found when microPTC were evaluated, we show that tumors measuring 7-10  mm, which were positive for BRAF mutation, presented more aggressive features and lower expression of NIS and TPO. We believe that our findings will help to decide the realistic usefulness of BRAF V600E mutation as a preoperative marker of poor prognosis in small PTC, primarily in microPTC. © 2015 European Society of Endocrinology.

  20. “GUERRA DE OLHARES”: EMULAÇÃO E AGUDEZA EM VÊNUS E ADÔNIS (1593, DE WILLIAM SHAKESPEARE

    Directory of Open Access Journals (Sweden)

    Lavinia Silvares

    2013-12-01

    Full Text Available Neste artigo, proponho investigar alguns aspectos da relação entre a emulação dos antigos e a produção da agudeza em Vênus e Adônis, de Shakespeare, publicado pela primeira vez em 1593, em Londres. Nesse poema narrativo, a emulação de uma passagem das Metamorfoses de Ovídio é explícita e marca o lugar de autoridade a partir do qual diversas técnicas retórico-poéticas de amplificação do tópico inventivo e elocutivo serão empregadas para efetuar a agudeza do poema. Assim, proponho discutir como se legitimam as novidades de matéria e estilo poético em Vênus e Adônis ao mesmo tempo em que se preservam, retoricamente, as relações de pertencimento à autoridade antiga imitada. Para esse propósito, refiro-me a um texto preceptivo da época, o Discurso comparativo, de Francis Meres, para discutir como se realiza a operação de associação dos “novos” poetas a autoridades antigas.

  1. Blood response to plasticized poly(vinyl chloride): dependence of fibrinogen adsorption on plasticizer selection and surface plasticizer level.

    Science.gov (United States)

    Zhao, X B; Courtney, J M

    2003-10-01

    The high level of plasticizer in plasticized poly(vinyl chloride) (PVC) ensures that plasticizer selection has an important influence on the suitability of PVC to function in blood-contacting applications. In this study, three types of plasticized PVC in sheet form, with di-(2-ethylhexyl)phthalate (DEHP), tri-(2-ethylhexyl)trimellitate (TEHTM) and n-butyryltri-n-hexyl citrate (BTHC) as plasticizer, were selected for assessment and single solute fibrinogen adsorption was utilized as an initial index of interactions with blood components. Fibrinogen adsorption behavior shows a strong dependence on the plasticizer selection, plasticizer level at the surface and the adsorption conditions, such as adsorption time and fibrinogen solution concentration. Results indicate that BTHC plasticized PVC possesses the lowest adsorption capacity in the three types of plasticized PVC, while TEHTM plasticized PVC seems to have the strongest reactivity in certain fibrinogen solution concentrations. The alteration of surface plasticizer level was achieved by a methanol-cleaning treatment with a variety of cleaning times and the fibrinogen adsorption on plasticized PVC decreases with the reduction of surface plasticizer level. The migration behavior of two phthalate esters (DEHP and TEHTM) was evaluated using UV-Spectrophotometer to determine the plasticizer level at the surfaces. In addition, the fibrinogen adsorption mechanism was examined with Freundlich adsorption modeling.

  2. Chemical bonding of water to metal surfaces studied with core-level spectroscopies

    DEFF Research Database (Denmark)

    Schiros, T.; Andersson, Klas Jerker; Pettersson, L.G.M.

    2010-01-01

    The nature of the contact layer of water on surfaces is of relevance for many practical fields, including corrosion, electrochemistry, environmental science and heterogeneous catalysis. Here we focus on the geometric and electronic structure of the water contact layer on transition metal surfaces......-specific information on the partial local density of states, local atomic structure, geometrical parameters and molecular orientation, allowing general principles for water-metal interaction to be derived....

  3. Derivation of Waste Acceptance Criteria for Low and Intermediate Level Waste in Surface Disposal Facility

    International Nuclear Information System (INIS)

    Gagner, L.; Voinis, S.

    2000-01-01

    In France, low- and intermediate-level radioactive wastes are disposed in a near-surface facility, at Centre de l'Aube disposal facility. This facility, which was commissioned in 1992, has a disposal capacity of one million cubic meters, and will be operated up to about 2050. It took over the job from Centre de la Manche, which was commissioned in 1969 and shut down in 1994, after having received about 520,000 cubic meters of wastes. The Centre de l'Aube disposal facility is designed to receive a many types of waste produced by nuclear power plants, reprocessing, decommissioning, as well as by the industry, hospitals and armed forces. The limitation of radioactive transfer to man and the limitation of personnel exposure in all situations considered plausible require limiting the total activity of the waste disposed in the facility as well as the activity of each package. The paper presents how ANDRA has derived the activity-related acceptance criteria, based on the safety analysis. In the French methodology, activity is considered as end-point for deriving the concentration limits per package, whereas it is the starting point for deriving the total activity limits. For the concentration limits (called here LMA) the approach consists of five steps: the determination of radionuclides important for safety with regards to operational and long-term safety, the use of relevant safety scenarios as a tool to derive quantitative limits, the setting of dose constraint per situation associated with scenarios, the setting of contribution factor per radionuclide, and the calculation of concentration activity limits. An exhaustive survey has been performed and has shown that the totality of waste packages which should be delivered by waste generators are acceptable in terms of activity limits in the Centre de l'Aube. Examples of concentration activity limits derived from this methodology are presented. Furthermore those limits have been accepted by the French regulatory body and

  4. Contamination levels of human pharmaceutical compounds in French surface and drinking water.

    Science.gov (United States)

    Mompelat, S; Thomas, O; Le Bot, B

    2011-10-01

    The occurrence of 20 human pharmaceutical compounds and metabolites from 10 representative therapeutic classes was analysed from resource and drinking water in two catchment basins located in north-west France. 98 samples were analysed from 63 stations (surface water and drinking water produced from surface water). Of the 20 human pharmaceutical compounds selected, 16 were quantified in both the surface water and drinking water, with 22% of the values above the limit of quantification for surface water and 14% for drinking water). Psychostimulants, non-steroidal anti-inflammatory drugs, iodinated contrast media and anxiolytic drugs were the main therapeutic classes of human pharmaceutical compounds detected in the surface water and drinking water. The results for surface water were close to results from previous studies in spite of differences in prescription rates of human pharmaceutical compounds in different countries. The removal rate of human pharmaceutical compounds at 11 water treatment units was also determined. Only caffeine proved to be resistant to drinking water treatment processes (with a minimum rate of 5%). Other human pharmaceutical compounds seemed to be removed more efficiently (average elimination rate of over 50%) by adsorption onto activated carbon and oxidation/disinfection with ozone or chlorine (not taking account of the disinfection by-products). These results add to the increasing evidence of the occurrence of human pharmaceutical compounds in drinking water that may represent a threat to human beings exposed to a cocktail of human pharmaceutical compounds and related metabolites and by-products in drinking water.

  5. Accurate high level ab initio-based global potential energy surface and dynamics calculations for ground state of CH2(+).

    Science.gov (United States)

    Li, Y Q; Zhang, P Y; Han, K L

    2015-03-28

    A global many-body expansion potential energy surface is reported for the electronic ground state of CH2 (+) by fitting high level ab initio energies calculated at the multireference configuration interaction level with the aug-cc-pV6Z basis set. The topographical features of the new global potential energy surface are examined in detail and found to be in good agreement with those calculated directly from the raw ab initio energies, as well as previous calculations available in the literature. In turn, in order to validate the potential energy surface, a test theoretical study of the reaction CH(+)(X(1)Σ(+))+H((2)S)→C(+)((2)P)+H2(X(1)Σg (+)) has been carried out with the method of time dependent wavepacket on the title potential energy surface. The total integral cross sections and the rate coefficients have been calculated; the results determined that the new potential energy surface can both be recommended for dynamics studies of any type and as building blocks for constructing the potential energy surfaces of larger C(+)/H containing systems.

  6. Atomic-Level Simulation Study of n-Hexane Pyrolysis on Silicon Carbide Surfaces.

    Science.gov (United States)

    Sajib, Md Symon Jahan; Samieegohar, Mohammadreza; Wei, Tao; Shing, Katherine

    2017-10-24

    Ethylene production plays a key role in the petrochemical industry. The severe operation conditions of ethylene thermal cracking, such as high-temperature and coke-formation, pose challenges for the development of new corrosion-resistant and coking-resistant materials for ethylene reactor radiant coils tubes (RCTs). We investigated the performance of ceramic materials such as silicon carbide (SiC) in severe pyrolysis conditions by using reactive force field molecular dynamics (ReaxFF MD) simulation method. Our results indicate that β-SiC surface remains fully stable at 1500 K, whereas increased temperature results in melted interface. At 2500 K, fully grown cross-linked-graphene-like polycyclic aromatic hydrocarbon coking structure on SiC surfaces was observed. Such coking was particularly severe in the carbon-side of the surface slab. The coking structures were mainly derived from surface atoms at the initial 3.0 ns, as a result of the loss of interfacial hydroxyl layer and further hydrothermal corrosion. The SiC substrate surface enhances the ethylene cracking rate and also leads to different intermediate-state compounds. Our fundamental research will have significant and broad impact on both petrochemical industry and academic research in materials science, petrochemistry, and combustion chemistry.

  7. Chemical bonding of water to metal surfaces studied with core-level spectroscopies

    International Nuclear Information System (INIS)

    Schiros, T.; Andersson, K.J.; Pettersson, L.G.M.; Nilsson, A.; Ogasawara, H.

    2010-01-01

    The nature of the contact layer of water on surfaces is of relevance for many practical fields, including corrosion, electrochemistry, environmental science and heterogeneous catalysis. Here we focus on the geometric and electronic structure of the water contact layer on transition metal surfaces and the interaction between the water monolayer and the surface. By combining synchrotron radiation-based X-ray photoelectron spectroscopy (XPS), X-ray absorption spectroscopy (XAS) and X-ray emission spectroscopy (XES) techniques with density functional theory (DFT) computational methods we obtain element-specific information on the partial local density of states, local atomic structure, geometrical parameters and molecular orientation, allowing general principles for water-metal interaction to be derived.

  8. Surface Plasmon Resonance Biosensor for Rapid Label-Free Detection of Microribonucleic Acid at Subfemtomole Level

    Czech Academy of Sciences Publication Activity Database

    Šípová, Hana; Zhang, S.-Ch.; Dudley, A.M.; Galas, D.; Wang, K.; Homola, Jiří

    2010-01-01

    Roč. 82, č. 24 (2010), s. 10110-10115 ISSN 0003-2700 R&D Projects: GA AV ČR KAN200670701 Institutional research plan: CEZ:AV0Z20670512 Keywords : surface plasmon resonance * microRNA * cancer diagnostics * biosensor Subject RIV: JB - Sensors, Measurment, Regulation Impact factor: 5.874, year: 2010

  9. Combination therapy and evaluation of therapeutic effect in hepatocellular carcinoma cell using triple reporter genes; containing for NIS, HSV1-sr39tk and GFP

    Energy Technology Data Exchange (ETDEWEB)

    Lee, You La; Lee, Yong Jin; Ahn, Sohn Joo; Ahn, Byeong Cheol; Lee, Sang Woo; Yoo, Jeong Soo; Lee, Jae Tae [Kyungpook National University, Daegu (Korea, Republic of)

    2007-07-01

    To identify therapeutic effect after combine Sodium Iodine Symporter (NIS) and Mutant Herpes-simplex virus type 1 sr39tk (HSV1-sr39tk) expression in hepatocellular carcinoma cell, we transfected triple gene and investigated the properties of these gene ability in hepatocellular carcinoma cell line. After making vector with gene encoding a fusion protein comprised of HSV1-sr39tk and green florescence protein (GFP), to make triple reporter genes NIS gene was further fused to the vector using IRES vector. The vector expressing triple reporter gene was transfected to the Huh-7 cell line using liposome. Functions of hNIS and HSV1-sr39tk expression were confirmed by radio iodine uptake with and without perchlorate and [3H]-penciclovir (3-H PCV) uptake, respectively. To evaluate therapeutic effect in vitro, GCV and I-131 was treated in Huh-7/NTG cell and dual therapy performed. An animal imaging acquired using Optix and microPET in vivo. I-125 uptake was increased up to 100-fold compare to that of non-transfected cells. The transfected cell accumulated H-3 PCV up to 53 times higher at 2 hour than that of non-transfected cells. With fluorescence microscopy, green fluorescence was detected in the transfected cell. In cytotoxic studies, the cell viability of Huh-7/NTG cell was decreased to 41 % of control cell at 10ug/ml GCV concentrations. The survival rate of the Huh-7/NTG cell treated with I-131 decreased up to 16%. In I-131 and GCV dual therapy, Huh-7/NTG cell survival rate decreased up to 4%. In animal studies, Huh-7/NTG tumors showed higher uptake of 18F-FHBG and I-124 than Huh-7 tumors. GFP signal is also higher in Huh-7/NTG tumor than control. We successfully constructed a vector with delivery two therapeutic genes and one reporter gene and transfected the vector to a Huh-7 cell. The hepatocellular carcinoma cell transfected with the vector can be treated with GCV and I-131. The effect of dual gene therapy could be easily assessed by the optical reporter gene imaging.

  10. Distribution of energy levels of quantum free particle on the Liouville surface and trace formulae

    International Nuclear Information System (INIS)

    Bleher, P.M.; Kosygin, D.V.; Sinai, Y.G.

    1995-01-01

    We consider the Weyl asymptotic formula [{E n ≤R 2 }=Area Q.R 2 /(4π)+n(R), for eigenvalues of the Laplace-Beltrami operator on a two-dimensional torus Q with a Liouville metric which is in a sense the most general case of an integrable metric. We prove that if the surface Q is non-degenerate then the remainder term n(R) has the form n(R)=R 1/2 θ(R), where θ(R) is an almost periodic function of the Besicovitch class B 1 , and the Fourier amplitudes and the Fourier frequencies of θ(R) can be expressed via lengths of closed geodesics on Q and other simple geometric characteristics of these geodesics. We prove then that if the surface Q is generic then the limit distribution of θ(R) has a density p(t), which is an entire function of t possessing an asymptotics on a real line, logp(t)∝-C ± t 4 as t→±∞. An explicit expression for the Fourier transform of p(t) via Fourier amplitudes of θ(R) is also given. We obtain the analogue of the Guillemin-Duistermaat trace formula for the Liouville surfaces and discuss its accuracy. (orig.)

  11. Optimization of meat level and processing conditions for development of chicken meat noodles using response surface methodology.

    Science.gov (United States)

    Khare, Anshul Kumar; Biswas, Asim Kumar; Balasubramanium, S; Chatli, Manish Kumar; Sahoo, Jhari

    2015-06-01

    Response surface methodology (RSM) is a mathematical and statistical technique for testing multiple process variables and their interactive, linear and quadratic effects, and useful in solving multivariable equations obtained from experiments simultaneously. In present study optimum meat level and processing conditions for development of shelf stable chicken meat noodles was determined using central composite design of response surface methodology (RSM). Effects of meat level (110-130 g); processing conditions such as steaming time (12-18 min) and drying time (7-9 h) on the water activity, yield, water absorption index, water solubility index, hardness, overall acceptability and total colour change of chicken noodles were investigated. The aim of present study was to optimize meat level and processing conditions for development of chicken noodles. The coefficients of determination, R(2) of all the response variables were higher than 0.8. Based on the response surface and superimposed plots, the optimum conditions such as 60 % meat level, 12 min steaming time and 9 h drying time for development of chicken noodles with desired sensory quality was obtained.

  12. The Department of Baltic Philology (1921–1940 established by Jānis Endzelīns at the University of Latvia

    Directory of Open Access Journals (Sweden)

    Sarma Kļaviņa

    2014-06-01

    Full Text Available The article is devoted to the history of the Department of Baltic Philology of the Faculty of Philology and Philosophy at the University of Latvia. The department was established in the academic year of 1920/1921 by professor Jānis Endzelīns, who also acted as head of the department throughout its existence. Using the documents available at the Latvian State Historical Archives and the Museum of the University of Latvia, as well as published memories, the article provides a characterization of the establishment process of this department as an unprecedented one among the universities around the globe. The article also describes study programmes and their development, students and graduates, academic personnel, international relations of the department and its reputation.

  13. DIFFERENCES IN BIOMECHANICAL PROPERTIES OF KNEE EXTENSOR REBOUND WITH THE DIFFERENT SURFACE ELASTICITY

    Directory of Open Access Journals (Sweden)

    Katarina Herodek

    2013-07-01

    Full Text Available The sample includes 40 subjects of both sexes: male (20 and female (20 population of students of the Faculty of Sport and Physical Education, University of Nis. The research involves the application of the rebound in gymnastics with two different heights (40 and 50cm on three different surfaces of elasticity: hard, demyelastic and elastic surface. The subject of the research were the dynamic parameters of movement laid down from Drop Jump (DJ with Myotest device and in the following parameters: height (in cm, power (in W/ kg, force (in N/ kg and speed (cm/ s. Using canonical-discrimination analysis showed no statistically significant differences in the performance jump of hard and demyelastic surface from a height 40 cm and 50 cm for men and women, thethe studied parameters (height, strength ,power and speed of the bounce . Revealed a statistically significant difference in performance with the elastic rebound surface elevations of 40 cm and 50 cm for men and women (p = 0.00. Of the examined parameters was obtained that there are significant differences in the Force reflection to the significance level of 98% (0.0255 and the power of reflection on the significance level of 100% (0.0009 in men. In women of the examined parameters was obtained a statistically significant difference in the strength of the rebound only from positions of 40cm and 50cm and 100% (0.0075.

  14. GHRSST Level 4 AVHRR_OI Global Blended Sea Surface Temperature Analysis (GDS version 2) from NCEI (GDS versions 1 and 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) global Level 4 sea surface temperature analysis produced daily on a 0.25 degree grid at the NOAA...

  15. GHRSST Level 2P Global Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-17 satellite produced by NAVO (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A global Group for High Resolution Sea Surface Temperature (GHRSST) Level 2P dataset based on multi-channel sea surface temperature (SST) retrievals generated in...

  16. GHRSST Level 2P Atlantic Regional Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-17 satellite (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A regional Level 2P Group for High Resolution Sea Surface Temperature (GHRSST) dataset for the Atlantic Ocean and nearby regions based on multi-channel sea surface...

  17. GHRSST Level 2P Global Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-17 satellite (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A global Level 2P Group for High Resolution Sea Surface Temperature (GHRSST) dataset based on multi-channel sea surface temperature (SST) retrievals from the...

  18. GHRSST Level 2P Atlantic Regional Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-16 satellite (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A regional Level 2P Group for High Resolution Sea Surface Temperature (GHRSST) dataset for the Atlantic Ocean and nearby regions based on multi-channel sea surface...

  19. GHRSST Level 2P Regional Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-18 satellite produced by NAVO (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A regional Group for High Resolution Sea Surface Temperature (GHRSST) Level 2P dataset based on multi-channel sea surface temperature (SST) retrievals generated in...

  20. GHRSST Level 2P Global Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-16 satellite (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A global Level 2P Group for High Resolution Sea Surface Temperature (GHRSST) dataset based on multi-channel sea surface temperature (SST) retrievals from the...

  1. Implications of long-term surface or near-surface storage of intermediate and low-level wastes in the UK

    International Nuclear Information System (INIS)

    Murray, N.; Vande Putte, D.; Ware, R.J.

    1986-02-01

    Various options for 200 year-long storage of all Low- and Intermediate-Level wastes generated to the year 2030 are considered. On-site storage and centralised storage have been examined and compared. The feasibility of storing some of the wastes in underground facilities that are convertible to repositories has been demonstrated, but it is shown that centralised, surface storage of wastes would be more economical. There appears to be little merit in storing Intermediate Level wastes in separate facilities that could be converted to repositories. Storage is shown to be more expensive than direct disposal, except if future costs are discounted by more than about 10%. With carefully designed stores and remote handling, the collective dose to operators could be limited to about 20-40 man Sv over the whole period of storage. (author)

  2. Long-range surface-plasmon-polariton excitation at the quantum level

    International Nuclear Information System (INIS)

    Ballester, D.; Tame, M. S.; Kim, M. S.; Lee, C.; Lee, J.

    2009-01-01

    We provide the quantum-mechanical description of the excitation of long-range surface-plasmon polaritons (LRSPPs) on thin metallic strips. The excitation process consists of an attenuated-reflection setup, where efficient photon-to-LRSPP wave-packet transfer is shown to be achievable. For calculating the coupling, we derive the first quantization of LRSPPs in the polaritonic regime. We study quantum statistics during propagation and characterize the performance of photon-to-LRSPP quantum state transfer for single-photons, photon-number states, and photonic coherent superposition states.

  3. Investigating oligonucleotide hybridization at subnanomolar level by surface plasmon resonance biosensor method

    Czech Academy of Sciences Publication Activity Database

    Vaisocherová, Hana; Zítová, Alice; Lachmanová, Markéta; Štepánek, J.; Králíková, Šárka; Liboska, Radek; Rejman, Dominik; Rosenberg, Ivan; Homola, Jiří

    2006-01-01

    Roč. 82, č. 4 (2006), s. 394-398 ISSN 0006-3525. [European Conference on the Spectroscopy of Biological Molecules - ECSBM 2005 /11./. Aschaffenburg, 03.09.2005-08.09.2005] R&D Projects: GA ČR(CZ) GA303/03/0249; GA ČR(CZ) GA102/03/0633; GA ČR(CZ) GA202/05/0628 Institutional research plan: CEZ:AV0Z20670512; CEZ:AV0Z40550506 Keywords : surface plasmon resonance * biosensors * optical sensors Subject RIV: BO - Biophysics Impact factor: 2.480, year: 2006

  4. Quartz exposure levels in the underground and surface coal mining industry

    Energy Technology Data Exchange (ETDEWEB)

    Ainsworth, S.M.; Gero, A.J.; Parobeck, P.S; Tomb, T.F. [US Mine Safety and Health Administration, Pittsburgh, PA (United States)

    1995-10-01

    Occupational quartz exposure data gathered from the Mine Safety and Health Adminsitration`s respirable dust enforcement program and a program to monitor quartz exposure in several mining occupations were compiled and analyzed to assess the status of quartz exposures in the coal mining industry. The analysis showed that, in underground mines, a substantial number of samples contained greater than 5% quartz. Occupations that showed a high frequency of excessive quartz exposure included the roof bolter, continuous miner operator, and continuous miner operator helper. In surface coal mines the highwall drill operator and helper, bulldozer operator, scraper operator, and truck driver were frequently exposed to high quartz concentrations.

  5. Mechanisms and rates of proton transfer to coordinated carboxydithioates: studies on [Ni(S2CR){PhP(CH2CH2PPh2)2}](+) (R = Me, Et, Bu(n) or Ph).

    Science.gov (United States)

    Alwaaly, Ahmed; Clegg, William; Henderson, Richard A; Probert, Michael R; Waddell, Paul G

    2015-02-21

    The complexes [Ni(S2CR)(triphos)]BPh4 (R = Me, Et, Bu(n) or Ph; triphos = PhP{CH2CH2PPh2}2) have been prepared and characterised. X-ray crystallography (for R = Et, Ph, C6H4Me-4, C6H4OMe-4 and C6H4Cl-4) shows that the geometry of the five-coordinate nickel in the cation is best described as distorted trigonal bipyramidal, containing a bidentate carboxydithioate ligand with the two sulfur atoms spanning axial and equatorial sites, the other axial site being occupied by the central phosphorus of triphos. The reactions of [Ni(S2CR)(triphos)](+) with mixtures of HCl and Cl(-) in MeCN to form equilibrium solutions containing [Ni(SH(S)CR)(triphos)](2+) have been studied using stopped-flow spectrophotometry. The kinetics show that proton transfer is slower than the diffusion-controlled limit and involves at least two coupled equilibria. The first step involves the rapid association between [Ni(S2CR)(triphos)](+) and HCl to form the hydrogen-bonded precursor, {[Ni(S2CR)(triphos)](+)HCl} (K) and this is followed by the intramolecular proton transfer (k) to produce [Ni(SH(S)CR)(triphos)](2+). In the reaction of [Ni(S2CMe)(triphos)](+) the rate law is consistent with the carboxydithioate ligand undergoing chelate ring-opening after protonation. It seems likely that chelate ring-opening occurs for all [Ni(S2CR)(triphos)](+), but only with [Ni(S2CMe)(triphos)](+) is the protonation step sufficiently fast that chelate ring-opening is rate-limiting. With all other systems, proton transfer is rate-limiting. DFT calculations indicate that protonation can occur at either sulfur atom, but only protonation at the equatorial sulfur results in chelate ring-opening. The ways in which protonation of either sulfur atom complicates the analyses and interpretation of the kinetics are discussed.

  6. Prediction of protein retention times in hydrophobic interaction chromatography by robust statistical characterization of their atomic-level surface properties.

    Science.gov (United States)

    Hanke, Alexander T; Klijn, Marieke E; Verhaert, Peter D E M; van der Wielen, Luuk A M; Ottens, Marcel; Eppink, Michel H M; van de Sandt, Emile J A X

    2016-03-01

    The correlation between the dimensionless retention times (DRT) of proteins in hydrophobic interaction chromatography (HIC) and their surface properties were investigated. A ternary atomic-level hydrophobicity scale was used to calculate the distribution of local average hydrophobicity across the proteins surfaces. These distributions were characterized by robust descriptive statistics to reduce their sensitivity to small changes in the three-dimensional structure. The applicability of these statistics for the prediction of protein retention behaviour was looked into. A linear combination of robust statistics describing the central tendency, heterogeneity and frequency of highly hydrophobic clusters was found to have a good predictive capability (R2  = 0.78), when combined a factor to account for protein size differences. The achieved error of prediction was 35% lower than for a similar model based on a description of the protein surface on an amino acid level. This indicates that a robust and mathematically simple model based on an atomic description of the protein surface can be used for the prediction of the retention behaviour of conformationally stable globular proteins with a well determined 3D structure in HIC. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:372-381, 2016. © 2016 American Institute of Chemical Engineers.

  7. Dexamethasone reduces cell surface levels of CD11b on human eosinophils

    Directory of Open Access Journals (Sweden)

    A. M. Das

    1997-01-01

    Full Text Available Overnight incubation of human eosinophils (Eøs with the glucocorticoid hormone dexamethasone (DEX; 0.1 μM resulted in lower expression of the CD11b, but not CD49d, antigen on their plasma membrane, as assessed by flow cytometry. DEX produced a consistent inhibitory effect (ranging from 16% to 20% when tested at a concentration of 0.1 μM. Eø stimulation with 100 ng/ml eotaxin produced an increase in CD11b (+26%, but not CD11c, levels and concomitantly a reduction (–25% on CD62L expression. The inhibition exerted by DEX upon CD11b levels was also evident following eotaxin upregulation, with a degree of inhibition similar to that seen on basal levels. These data highlight a novel mechanism of action by which glucocorticoid hormones may be effective in reducing Eø accumulation during allergic inflammation in man.

  8. Global Sea Surface Temperature and Sea Level Rise Estimation with Optimal Historical Time Lag Data

    Directory of Open Access Journals (Sweden)

    Mustafa M. Aral

    2016-11-01

    Full Text Available Prediction of global temperatures and sea level rise (SLR is important for sustainable development planning of coastal regions of the world and the health and safety of communities living in these regions. In this study, climate change effects on sea level rise is investigated using a dynamic system model (DSM with time lag on historical input data. A time-invariant (TI-DSM and time-variant dynamic system model (TV-DSM with time lag is developed to predict global temperatures and SLR in the 21st century. The proposed model is an extension of the DSM developed by the authors. The proposed model includes the effect of temperature and sea level states of several previous years on the current temperature and sea level over stationary and also moving scale time periods. The optimal time lag period used in the model is determined by minimizing a synthetic performance index comprised of the root mean square error and coefficient of determination which is a measure for the reliability of the predictions. Historical records of global temperature and sea level from 1880 to 2001 are used to calibrate the model. The optimal time lag is determined to be eight years, based on the performance measures. The calibrated model was then used to predict the global temperature and sea levels in the 21st century using a fixed time lag period and moving scale time lag periods. To evaluate the adverse effect of greenhouse gas emissions on SLR, the proposed model was also uncoupled to project the SLR based on global temperatures that are obtained from the Intergovernmental Panel on Climate Change (IPCC emission scenarios. The projected SLR estimates for the 21st century are presented comparatively with the predictions made in previous studies.

  9. Design and operational considerations of United States commercial nea-surface low-level radioactive waste disposal facilities

    International Nuclear Information System (INIS)

    Birk, Sandra M.

    1997-01-01

    Low-level radioactive waste disposal standards and techniques in the United States have evolved significantly since the early 1960's. Six commercial LLW disposal facilities(Barnwell, Richland, Ward Valley, Sierra Blanca, Wake County and Boyd County) operated and proposed between 1962 and 1997. This report summarizes each site's design and operational considerations for near-surface disposal of low-level radioactive waste. These new standards and mitigating efforts at closed facilities (Sheffield, Maxey Flats, Beatty and West Valley) have helped to ensure that the public has been safely protected from LLW. 15 refs

  10. Determination of low-level tritium concentrations in surface water and precipitation in the Czech Republic

    International Nuclear Information System (INIS)

    Maresova, Diana; Hanslik, Eduard; Sedlarova, Barbora; Juranova, Eva; Charles University, Prague

    2017-01-01

    Past tests of nuclear weapons in the atmosphere, nuclear energy facilities and tritium of natural origin are main sources of tritium in the environment. Thanks to its presence in environment and its favourable properties, tritium is used as a radiotracer. Since stopping of atmospheric nuclear tests, tritium in precipitation has been decreasing towards natural levels below 1 Bq l -1 and precise analyses of low level tritium activities are necessary. This paper focuses on tritium development at sites not influenced by any technogenic release of tritium in Elbe River basin (Bohemia) in the Czech Republic using liquid scintillation measurement with electrolytic enrichment. (author)

  11. Tropical Pacific sea-surface temperatures and preceding sea level pressure anomalies in the subtropical North Pacific

    Science.gov (United States)

    Anderson, Bruce T.

    2003-12-01

    The correspondence of sea-surface temperature (SST) anomalies to changes in antecedent large-scale sea level pressure anomalies is investigated using reanalysis data. By statistically examining linearly coupled precursor sea level pressure fields and subsequent SST fields for different lag periods, it is possible to isolate a precursor mode of sea level pressure (SLP) variability in the central subtropical North Pacific that precedes variations in the January-March El Niño/Southern Oscillation (ENSO) by approximately 12-15 months. A sea level pressure index, which captures the important characteristics of this precursor mode of variability, is developed and evaluated. It is shown that both analyzed and observed versions of the index are significantly correlated with the January-March ENSO one year later. The SLP index is then used to examine the evolution of the surface circulation and temperature structures leading up to mature ENSO events. Initially, the January-March subtropical North Pacific SLP anomalies are associated with changes in the intensity of the subtropical trade wind regime over the North Pacific, as well as with SST anomalies over the eastern equatorial Pacific and subtropical central Pacific. In agreement with the correlation statistics associated with the SLP and lagged NINO3.4 indices, both the sea level pressure field and the SST field subsequently develop ENSO-like structures over the course of the following year. Significant discussion of these results and pertinent areas of future research are provided within the broader context of the ENSO system.

  12. Created mangrove wetlands store belowground carbon and surface elevation change enables them to adjust to sea-level rise.

    Science.gov (United States)

    Krauss, Ken W; Cormier, Nicole; Osland, Michael J; Kirwan, Matthew L; Stagg, Camille L; Nestlerode, Janet A; Russell, Marc J; From, Andrew S; Spivak, Amanda C; Dantin, Darrin D; Harvey, James E; Almario, Alejandro E

    2017-04-21

    Mangrove wetlands provide ecosystem services for millions of people, most prominently by providing storm protection, food and fodder. Mangrove wetlands are also valuable ecosystems for promoting carbon (C) sequestration and storage. However, loss of mangrove wetlands and these ecosystem services are a global concern, prompting the restoration and creation of mangrove wetlands as a potential solution. Here, we investigate soil surface elevation change, and its components, in created mangrove wetlands over a 25 year developmental gradient. All created mangrove wetlands were exceeding current relative sea-level rise rates (2.6 mm yr -1 ), with surface elevation change of 4.2-11.0 mm yr -1 compared with 1.5-7.2 mm yr -1 for nearby reference mangroves. While mangrove wetlands store C persistently in roots/soils, storage capacity is most valuable if maintained with future sea-level rise. Through empirical modeling, we discovered that properly designed creation projects may not only yield enhanced C storage, but also can facilitate wetland persistence perennially under current rates of sea-level rise and, for most sites, for over a century with projected medium accelerations in sea-level rise (IPCC RCP 6.0). Only the fastest projected accelerations in sea-level rise (IPCC RCP 8.5) led to widespread submergence and potential loss of stored C for created mangrove wetlands before 2100.

  13. Created mangrove wetlands store belowground carbon and surface elevation change enables them to adjust to sea-level rise

    Science.gov (United States)

    Krauss, Ken W.; Cormier, Nicole; Osland, Michael J.; Kirwan, Matthew L.; Stagg, Camille L.; Nestlerode, Janet A.; Russell, Marc J.; From, Andrew; Spivak, Amanda C.; Dantin, Darrin D.; Harvey, James E.; Almario, Alejandro E.

    2017-01-01

    Mangrove wetlands provide ecosystem services for millions of people, most prominently by providing storm protection, food and fodder. Mangrove wetlands are also valuable ecosystems for promoting carbon (C) sequestration and storage. However, loss of mangrove wetlands and these ecosystem services are a global concern, prompting the restoration and creation of mangrove wetlands as a potential solution. Here, we investigate soil surface elevation change, and its components, in created mangrove wetlands over a 25 year developmental gradient. All created mangrove wetlands were exceeding current relative sea-level rise rates (2.6 mm yr−1), with surface elevation change of 4.2–11.0 mm yr−1 compared with 1.5–7.2 mm yr−1 for nearby reference mangroves. While mangrove wetlands store C persistently in roots/soils, storage capacity is most valuable if maintained with future sea-level rise. Through empirical modeling, we discovered that properly designed creation projects may not only yield enhanced C storage, but also can facilitate wetland persistence perennially under current rates of sea-level rise and, for most sites, for over a century with projected medium accelerations in sea-level rise (IPCC RCP 6.0). Only the fastest projected accelerations in sea-level rise (IPCC RCP 8.5) led to widespread submergence and potential loss of stored C for created mangrove wetlands before 2100.

  14. Contamination problems from glass beaker inner surface in low level Po-210 analysis

    Czech Academy of Sciences Publication Activity Database

    Kameník, Jan; Hölgye, Z.

    2010-01-01

    Roč. 283, č. 2 (2010), s. 493-495 ISSN 0236-5731 Institutional research plan: CEZ:AV0Z10480505 Keywords : Po-210 * Low-level analysis * Contamination Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 0.777, year: 2010

  15. Elevation of water table and various stratigraphic surfaces beneath e area low level waste disposal facility

    Energy Technology Data Exchange (ETDEWEB)

    Bagwell, Laura [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Bennett, Patti [; Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2017-11-02

    This memorandum describes work that supports revision of the Radiological Performance Assessment (PA) for the E Area Low Level Radioactive Waste Disposal Facility (LLRWDF). The work summarized here addresses portions of the PA Strategic Planning Team's recommendation #148b (Butcher and Phifer, 2016).

  16. Preferences of lame cows for type of surface and level of social contact in hospital pens

    DEFF Research Database (Denmark)

    Jensen, Margit Bak; Herskin, Mette S; Thomsen, Peter T.

    2015-01-01

    To investigate preferences of lame cows for flooring and level of social contact, 37 lame, lactating dairy cows (diagnosed with sole ulcer or white line disease) were housed individually for 6 d in experimental hospital pens, where they could choose between 2 equally sized areas (6m × 4.5m...

  17. Characterization of Drain Surface Water: Environmental Profile, Degradation Level and Geo-statistic Monitoring

    Directory of Open Access Journals (Sweden)

    Muhammad Waseem Mumtaz

    2015-12-01

    Full Text Available The physico-chemical characterization of the surface water. Samples was carried out collected from nine sampling points of drain passing by the territory of Hafizabad city, Punjab, Pakistan. The water of drain is used by farmers for irrigation purposes in nearby agricultural fields. Twenty water quality parameters were evaluated in three turns and the results obtained were compared with the National Environmental Quality Standards (NEQS municipal and industrial effluents prescribed limits. The highly significant difference (p0.05 was noted for temperature, pH, electrical conductivity, hardness, calcium, sodium, chemical oxygen demand and chloride among water samples from different sampling points. Furthermore, the experimental results of different water quality parameters studied at nine sampling points of the drain were used and interpolated in ArcGIS 9.3 environment system using kriging techniques to obtain calculated values for the remaining locations of the Drain.

  18. Accurate prediction of complex free surface flow around a high speed craft using a single-phase level set method

    Science.gov (United States)

    Broglia, Riccardo; Durante, Danilo

    2017-11-01

    This paper focuses on the analysis of a challenging free surface flow problem involving a surface vessel moving at high speeds, or planing. The investigation is performed using a general purpose high Reynolds free surface solver developed at CNR-INSEAN. The methodology is based on a second order finite volume discretization of the unsteady Reynolds-averaged Navier-Stokes equations (Di Mascio et al. in A second order Godunov—type scheme for naval hydrodynamics, Kluwer Academic/Plenum Publishers, Dordrecht, pp 253-261, 2001; Proceedings of 16th international offshore and polar engineering conference, San Francisco, CA, USA, 2006; J Mar Sci Technol 14:19-29, 2009); air/water interface dynamics is accurately modeled by a non standard level set approach (Di Mascio et al. in Comput Fluids 36(5):868-886, 2007a), known as the single-phase level set method. In this algorithm the governing equations are solved only in the water phase, whereas the numerical domain in the air phase is used for a suitable extension of the fluid dynamic variables. The level set function is used to track the free surface evolution; dynamic boundary conditions are enforced directly on the interface. This approach allows to accurately predict the evolution of the free surface even in the presence of violent breaking waves phenomena, maintaining the interface sharp, without any need to smear out the fluid properties across the two phases. This paper is aimed at the prediction of the complex free-surface flow field generated by a deep-V planing boat at medium and high Froude numbers (from 0.6 up to 1.2). In the present work, the planing hull is treated as a two-degree-of-freedom rigid object. Flow field is characterized by the presence of thin water sheets, several energetic breaking waves and plungings. The computational results include convergence of the trim angle, sinkage and resistance under grid refinement; high-quality experimental data are used for the purposes of validation, allowing to

  19. Imaging and Tuning Molecular Levels at the Surface of a Gated Graphene Device

    Science.gov (United States)

    2014-01-01

    Gate-controlled tuning of the charge carrier density in graphene devices provides new opportunities to control the behavior of molecular adsorbates. We have used scanning tunneling microscopy (STM) and spectroscopy (STS) to show how the vibronic electronic levels of 1,3,5-tris(2,2-dicyanovinyl)benzene molecules adsorbed onto a graphene/BN/SiO2 device can be tuned via application of a backgate voltage. The molecules are observed to electronically decouple from the graphene layer, giving rise to well-resolved vibronic states in dI/dV spectroscopy at the single-molecule level. Density functional theory (DFT) and many-body spectral function calculations show that these states arise from molecular orbitals coupled strongly to carbon–hydrogen rocking modes. Application of a back-gate voltage allows switching between different electronic states of the molecules for fixed sample bias. PMID:24746016

  20. The Sentinel-3 Surface Topography Mission (S-3 STM): Level 2 SAR Ocean Retracker

    Science.gov (United States)

    Dinardo, S.; Lucas, B.; Benveniste, J.

    2015-12-01

    The SRAL Radar Altimeter, on board of the ESA Mission Sentinel-3 (S-3), has the capacity to operate either in the Pulse-Limited Mode (also known as LRM) or in the novel Synthetic Aperture Radar (SAR) mode. Thanks to the initial results from SAR Altimetry obtained exploiting CryoSat-2 data, lately the interest by the scientific community in this new technology has significantly increased and consequently the definition of accurate processing methodologies (along with validation strategies) has now assumed a capital importance. In this paper, we present the algorithm proposed to retrieve from S-3 STM SAR return waveforms the standard ocean geophysical parameters (ocean topography, wave height and sigma nought) and the validation results that have been so far achieved exploiting the CryoSat-2 data as well as the simulated data. The inversion method (retracking) to extract from the return waveform the geophysical information is a curve best-fitting scheme based on the bounded Levenberg-Marquardt Least-Squares Estimation Method (LEVMAR-LSE). The S-3 STM SAR Ocean retracking algorithm adopts, as return waveform’s model, the “SAMOSA” model [Ray et al, 2014], named after the R&D project SAMOSA (led by Satoc and funded by ESA), in which it has been initially developed. The SAMOSA model is a physically-based model that offers a complete description of a SAR Altimeter return waveform from ocean surface, expressed in the form of maps of reflected power in Delay-Doppler space (also known as stack) or expressed as multilooked echoes. SAMOSA is able to account for an elliptical antenna pattern, mispointing errors in roll and yaw, surface scattering pattern, non-linear ocean wave statistics and spherical Earth surface effects. In spite of its truly comprehensive character, the SAMOSA model comes with a compact analytical formulation expressed in term of Modified Bessel functions. The specifications of the retracking algorithm have been gathered in a technical document (DPM

  1. An improved empirical dynamic control system model of global mean sea level rise and surface temperature change

    Science.gov (United States)

    Wu, Qing; Luu, Quang-Hung; Tkalich, Pavel; Chen, Ge

    2018-04-01

    Having great impacts on human lives, global warming and associated sea level rise are believed to be strongly linked to anthropogenic causes. Statistical approach offers a simple and yet conceptually verifiable combination of remotely connected climate variables and indices, including sea level and surface temperature. We propose an improved statistical reconstruction model based on the empirical dynamic control system by taking into account the climate variability and deriving parameters from Monte Carlo cross-validation random experiments. For the historic data from 1880 to 2001, we yielded higher correlation results compared to those from other dynamic empirical models. The averaged root mean square errors are reduced in both reconstructed fields, namely, the global mean surface temperature (by 24-37%) and the global mean sea level (by 5-25%). Our model is also more robust as it notably diminished the unstable problem associated with varying initial values. Such results suggest that the model not only enhances significantly the global mean reconstructions of temperature and sea level but also may have a potential to improve future projections.

  2. An improved empirical dynamic control system model of global mean sea level rise and surface temperature change

    Science.gov (United States)

    Wu, Qing; Luu, Quang-Hung; Tkalich, Pavel; Chen, Ge

    2017-03-01

    Having great impacts on human lives, global warming and associated sea level rise are believed to be strongly linked to anthropogenic causes. Statistical approach offers a simple and yet conceptually verifiable combination of remotely connected climate variables and indices, including sea level and surface temperature. We propose an improved statistical reconstruction model based on the empirical dynamic control system by taking into account the climate variability and deriving parameters from Monte Carlo cross-validation random experiments. For the historic data from 1880 to 2001, we yielded higher correlation results compared to those from other dynamic empirical models. The averaged root mean square errors are reduced in both reconstructed fields, namely, the global mean surface temperature (by 24-37%) and the global mean sea level (by 5-25%). Our model is also more robust as it notably diminished the unstable problem associated with varying initial values. Such results suggest that the model not only enhances significantly the global mean reconstructions of temperature and sea level but also may have a potential to improve future projections.

  3. TanDEM-X the Earth surface observation project from space level - basis and mission status

    Directory of Open Access Journals (Sweden)

    Jerzy Wiśniowski

    2015-03-01

    Full Text Available TanDEM-X is DLR (Deutsches Zentrum für Luft- und Raumfahrt the Earth surface observation project using high-resolution SAR interferometry. It opens a new era in space borne radar remote sensing. The system is based on two satellites: TerraSAR-X (TSX and TanDEM-X (TDX flying on the very close, strictly controlled orbits. This paper gives an overview of the radar technology and overview of the TanDEM-X mission concept which is based on several innovative technologies. The primary objective of the mission is to deliver a global digital elevation model (DEM with an unprecedented accuracy, which is equal to or surpass the HRTI-3 specifications (12 m posting, relative height accuracy ±2 m for slope < 20% and ±4 m for slope > 20% [8]. Beyond that, TanDEM-X provides a highly reconfigurable platform for the demonstration of new radar imaging techniques and applications.[b]Keywords[/b]: remote sensing, Bistatic SAR, digital elevation model (DEM, Helix formation, SAR interferomery, HRTI-3, synchronization

  4. Observation of core-level binding energy shifts between (100) surface and bulk atoms of epitaxial CuInSe{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, A.J. [Colorado School of Mines, Golden, CO (United States); Berry, G.; Rockett, A. [Univ. of Illinois, Urbana-Champaign, IL (United States)] [and others

    1997-04-01

    Core-level and valence band photoemission from semiconductors has been shown to exhibit binding energy differences between surface atoms and bulk atoms, thus allowing one to unambiguously distinguish between the two atomic positions. Quite clearly, surface atoms experience a potential different from the bulk due to the lower coordination number - a characteristic feature of any surface is the incomplete atomic coordination. Theoretical accounts of this phenomena are well documented in the literature for III-V and II-VI semiconductors. However, surface state energies corresponding to the equilibrium geometry of (100) and (111) surfaces of Cu-based ternary chalcopyrite semiconductors have not been calculated or experimental determined. These compounds are generating great interest for optoelectronic and photovoltaic applications, and are an isoelectronic analog of the II-VI binary compound semiconductors. Surface core-level binding energy shifts depend on the surface cohesive energies, and surface cohesive energies are related to surface structure. For ternary compound semiconductor surfaces, such as CuInSe{sub 2}, one has the possibility of variations in surface stoichiometry. Applying standard thermodynamical calculations which consider the number of individual surface atoms and their respective chemical potentials should allow one to qualitatively determine the magnitude of surface core-level shifts and, consequently, surface state energies.

  5. Effects of in-office and home bleaching gels on the surface mercury levels of dental amalgam.

    Science.gov (United States)

    Oskoee, Parnian Alizadeh; Kahnamoui, Mahdi Abed; Oskoee, Siavash Savadi; Zadfattah, Firooz; Pournaghi-Azar, Fatemeh

    2010-01-01

    The aim of this study was to evaluate the effect of different in-office and home bleaching gels on the surface mercury levels of dental amalgam. Sixty disk-shaped amalgam specimens (GS-80, SDI- Australia) were prepared and randomly divided into the following treatment groups: 1. Distilled water (control); 2. 15% home-bleach carbamide peroxide (Opalescence PF, Ultra dent, USA) applied for 6 h/day for 3 weeks; and 3. 35% in-office bleach carbamide peroxide (Opalescence Quick, Ultradent) applied for 30 min/week for 3 weeks. Levels of mercury were measured as weight percentages using an energy dispersive x-ray micro-analyzer detector connected to an electron microscope. Data was analyzed using one-way ANOVA and a post hoc Tukey tests (PP=0.71). However, both materials yielded significantly more mercury levels than that of the control group (Pamalgam in vitro.

  6. Investigation of Surface Pre-Treatment Methods for Wafer-Level Cu-Cu Thermo-Compression Bonding

    Directory of Open Access Journals (Sweden)

    Koki Tanaka

    2016-12-01

    Full Text Available To increase the yield of the wafer-level Cu-Cu thermo-compression bonding method, certain surface pre-treatment methods for Cu are studied which can be exposed to the atmosphere before bonding. To inhibit re-oxidation under atmospheric conditions, the reduced pure Cu surface is treated by H2/Ar plasma, NH3 plasma and thiol solution, respectively, and is covered by Cu hydride, Cu nitride and a self-assembled monolayer (SAM accordingly. A pair of the treated wafers is then bonded by the thermo-compression bonding method, and evaluated by the tensile test. Results show that the bond strengths of the wafers treated by NH3 plasma and SAM are not sufficient due to the remaining surface protection layers such as Cu nitride and SAMs resulting from the pre-treatment. In contrast, the H2/Ar plasma–treated wafer showed the same strength as the one with formic acid vapor treatment, even when exposed to the atmosphere for 30 min. In the thermal desorption spectroscopy (TDS measurement of the H2/Ar plasma–treated Cu sample, the total number of the detected H2 was 3.1 times more than the citric acid–treated one. Results of the TDS measurement indicate that the modified Cu surface is terminated by chemisorbed hydrogen atoms, which leads to high bonding strength.

  7. Body Surface Contamination Levels of Residents under Different Evacuation Scenarios after the Fukushima Daiichi Nuclear Power Plant Accident.

    Science.gov (United States)

    Ohba, Takashi; Hasegawa, Arifumi; Kohayagawa, Yoshitaka; Kondo, Hisayoshi; Suzuki, Gen

    2017-09-01

    Body surface contamination levels should be correlated with inhaled actual thyroid doses during evacuation following the Fukushima Daiichi nuclear power plant (FDNPP) accident. Evacuees and residents were screened for body surface contamination using a Geiger-Mueller survey meter. The authors obtained 7,539 individual screening data sheets as well as gamma-spectrometry data from measurements made on clothing of two subjects by using a germanium spectrometer. Body surface contamination levels were analyzed in four residential groups during two different periods: 12-14 and 15-17 March 2011. Contamination levels during 12-14 March in the Tomioka/Okuma/Futaba/Naraha group were very low, indicating that residents evacuated before the radioactive plume reached their towns on 12 March. In contrast, levels in the Namie and Minamisoma groups were higher than those in the other groups in both periods, indicating that these residents were exposed to plumes twice on 12 and 15-16 March. The plume on 12 March was enriched with short-lived radionuclides: averaged proportions of radioactivity (relative to I) from Te, I, and Cs measured in clothing from two subjects were 2.3, 1.1, and 0.1, respectively, after correction for physical decay by 12:00 on 12 March. These proportions are similar to those (relative to I) from Te and Cs in dust sampled by a high-volume air sampler in the zone 20 km from the FDNPP on 12 March: 1.9 and 0.1, respectively. These data indicate that the relative contribution to inhaled thyroid dose of short-lived radionuclides in radioactive plumes released on 12 March could be as much as 37.5% in 1-y-old children.

  8. Sea level height, sea surface temperature, and tuna yields in the Panama bight during El Niño

    Directory of Open Access Journals (Sweden)

    M. J. Pedraza

    2006-01-01

    Full Text Available Between 1988 and 1998, annual tuna landings at Buenaventura (Colombian Pacific are correlated with the sea surface temperature in the central Equatorial Pacific (r=0.78, p<0.05 and the sea level height at Buenaventura (r=0.76, p<0.05 and Balboa (Panama (r=0.79, p<0.05. Seasonal oceanic upwelling is forced by the Panama wind jet, which may favour oceanic fisheries such as tuna. Here we first apply a bivariate correlation method (Pyper and Peterman, 1994 and then a multivariate approach (principal components analysis or PCA to investigate the relationships of these environmental variables with landings. With the first method, we find that landing is best correlated with the sea surface temperature in the Niño 3 region, whereas the other relationships are less clear. In contrast, with PCA we find that PC1 explains 90.6% of the total variance and suggests that sea surface temperature plays a major role in determining tuna availability in the area (especially during El Niño events. Since PC2 is mainly correlated with sea level height at Balboa but only represents 6.8% of the total variance, we suggest that oceanic upwelling effects on tuna landings at Buenaventura are not significant at interannual scales.

  9. Highly Accurate Potential Energy Surface, Dipole Moment Surface, Rovibrational Energy Levels, and Infrared Line List for (32)S(16)O2 up to 8000 cm(exp -1)

    Science.gov (United States)

    Huang, Xinchuan; Schwenke, David W.; Lee, Timothy J.

    2014-01-01

    A purely ab initio potential energy surface (PES) was refined with selected (32)S(16)O2 HITRAN data. Compared to HITRAN, the root-mean-squares error (RMS) error for all J=0-80 rovibrational energy levels computed on the refined PES (denoted Ames-1) is 0.013 cm(exp -1). Combined with a CCSD(T)/aug-cc-pV(Q+d)Z dipole moment surface (DMS), an infrared (IR) line list (denoted Ames-296K) has been computed at 296K and covers up to 8,000 cm(exp -1). Compared to the HITRAN and CDMS databases, the intensity agreement for most vibrational bands is better than 85-90%. Our predictions for (34)S(16)O2 band origins, higher energy (32)S(16)O2 band origins and missing (32)S(16)O2 IR bands have been verified by most recent experiments and available HITRAN data. We conclude that the Ames-1 PES is able to predict (32/34)S(16)O2 band origins below 5500 cm(exp -1) with 0.01-0.03 cm(exp -1) uncertainties, and the Ames-296K line list provides continuous, reliable and accurate IR simulations. The Ka-dependence of both line position and line intensity errors is discussed. The line list will greatly facilitate SO2 IR spectral experimental analysis, as well as elimination of SO2 lines in high-resolution astronomical observations.

  10. County-Level Climate Uncertainty for Risk Assessments: Volume 14 Appendix M - Historical Surface Runoff.

    Energy Technology Data Exchange (ETDEWEB)

    Backus, George A.; Lowry, Thomas Stephen; Jones, Shannon M; Walker, La Tonya Nicole; Roberts, Barry L; Malczynski, Leonard A.

    2017-06-01

    This report uses the CMIP5 series of climate model simulations to produce country- level uncertainty distributions for use in socioeconomic risk assessments of climate change impacts. It provides appropriate probability distributions, by month, for 169 countries and autonomous-areas on temperature, precipitation, maximum temperature, maximum wind speed, humidity, runoff, soil moisture and evaporation for the historical period (1976-2005), and for decadal time periods to 2100. It also provides historical and future distributions for the Arctic region on ice concentration, ice thickness, age of ice, and ice ridging in 15-degree longitude arc segments from the Arctic Circle to 80 degrees latitude, plus two polar semicircular regions from 80 to 90 degrees latitude. The uncertainty is meant to describe the lack of knowledge rather than imprecision in the physical simulation because the emphasis is on unfalsified risk and its use to determine potential socioeconomic impacts. The full report is contained in 27 volumes.

  11. County-Level Climate Uncertainty for Risk Assessments: Volume 15 Appendix N - Forecast Surface Runoff.

    Energy Technology Data Exchange (ETDEWEB)

    Backus, George A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lowry, Thomas Stephen [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jones, Shannon M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Walker, La Tonya Nicole [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Roberts, Barry L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Malczynski, Leonard A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-05-01

    This report uses the CMIP5 series of climate model simulations to produce country- level uncertainty distributions for use in socioeconomic risk assessments of climate change impacts. It provides appropriate probability distributions, by month, for 169 countries and autonomous-areas on temperature, precipitation, maximum temperature, maximum wind speed, humidity, runoff, soil moisture and evaporation for the historical period (1976-2005), and for decadal time periods to 2100. It also provides historical and future distributions for the Arctic region on ice concentration, ice thickness, age of ice, and ice ridging in 15-degree longitude arc segments from the Arctic Circle to 80 degrees latitude, plus two polar semicircular regions from 80 to 90 degrees latitude. The uncertainty is meant to describe the lack of knowledge rather than imprecision in the physical simulation because the emphasis is on unfalsified risk and its use to determine potential socioeconomic impacts. The full report is contained in 27 volumes.

  12. Rapid detection of polychlorinated biphenyls at trace levels in real environmental samples by surface-enhanced Raman scattering.

    Science.gov (United States)

    Zhou, Qin; Zhang, Xian; Huang, Yu; Li, Zhengcao; Zhang, Zhengjun

    2011-01-01

    Detection of trace levels of persistent pollutants in the environment is difficult but significant. Organic pollutant homologues, due to their similar physical and chemical properties, are even more difficult to distinguish, especially in trace amounts. We report here a simple method to detect polychlorinated biphenyls (PCBs) in soil and distilled spirit samples by the surface-enhanced Raman scattering technique using Ag nanorod arrays as substrates. By this method, polychlorinated biphenyls can be detected to a concentration of 5 μg/g in dry soil samples within 1 minute. Furthermore, based on simulation and understanding of the Raman characteristics of PCBs, we recognized homologues of tetrachlorobiphenyl by using the surface-enhance Raman scattering method even in trace amounts in acetone solutions, and their characteristic Raman peaks still can be distinguished at a concentration of 10(-6) mol/L. This study provides a fast, simple and sensitive method for the detection and recognition of organic pollutants such as polychlorinated biphenyls.

  13. MEK Inhibition Leads To Lysosome-Mediated Na+/I- Symporter Protein Degradation In Human Breast Cancer Cells

    Science.gov (United States)

    Zhang, Zhaoxia; Beyer, Sasha; Jhiang, Sissy M

    2013-01-01

    The Na+/I- symporter (NIS) is a transmembrane glycoprotein that mediates active iodide uptake into thyroid follicular cells. NIS-mediated iodide uptake in thyroid cells is the basis for targeted radionuclide imaging and treatment of differentiated thyroid carcinomas and their metastases. Furthermore, NIS is expressed in many human breast tumors but not in normal non-lactating breast tissue, suggesting that NIS-mediated radionuclide uptake may also allow the imaging and targeted therapy of breast cancer. However, functional cell surface NIS expression is often low in breast cancer, making it important to uncover signaling pathways that modulate NIS expression at multiple levels, from gene transcription to post-translational processing and cell surface trafficking. In this study, we investigated NIS regulation in breast cancer by MEK (MAPK/ERK kinase) signaling, an important cell signaling pathway involved in oncogenic transformation. We found that MEK inhibition decreased NIS protein levels in all-trans retinoic acid (tRA)/hydrocortisone treated MCF-7 cells as well as human breast cancer cells expressing exogenous NIS. The decrease in NIS protein levels by MEK inhibition was not accompanied by a decrease in NIS mRNA or a decrease in NIS mRNA export from the nucleus to the cytoplasm. NIS protein degradation upon MEK inhibition was prevented by lysosome inhibitors, but not by proteasome inhibitors. Interestingly, NIS protein level was correlated with MEK/ERK activation in human breast tumors from a tissue microarray. Taken together, MEK activation appears to play an important role in maintaining NIS protein stability in human breast cancers. PMID:23404856

  14. High level theoretical study of binding and of the potential energy surface in benzene-hydride system

    Energy Technology Data Exchange (ETDEWEB)

    Coletti, Cecilia, E-mail: ccoletti@unich.it [Dipartimento di Scienze del Farmaco, Universita ' G. d' Annunzio' Chieti-Pescara, Via dei Vestini 31, 66100 Chieti (Italy); Re, Nazzareno [Dipartimento di Scienze del Farmaco, Universita ' G. d' Annunzio' Chieti-Pescara, Via dei Vestini 31, 66100 Chieti (Italy)

    2012-04-04

    Graphical abstract: In-plane minimum geometries for benzene-H{sup -} non-covalent adducts: linear adduct (left) with the hydride ion hydrogen bonded to one aromatic hydrogen; bifurcated adduct (right), with the hydride ion hydrogen bonded to two adjacent aromatic hydrogens. Highlights: Black-Right-Pointing-Pointer Theoretical study on covalent and non-covalent binding in benzene-hydride. Black-Right-Pointing-Pointer Two non-covalent stable adducts were characterized in the in-plane geometry. Black-Right-Pointing-Pointer Significant sections of the potential energy surface were determined. Black-Right-Pointing-Pointer Formation of a very stable C{sub 6}H{sub 7}{sup -} anion upon covalent binding to carbon. - Abstract: High level ab initio calculations were performed on the interaction of the hydride anion with benzene, a system of potential interest for modelling the interactions occurring in hydrogen rich planetary atmospheres. We investigated both non-covalent and covalent binding, exploring the complete basis set limit using highly correlated MP2 and CCSD(T) levels of theory. Two non-covalent minima on the potential energy surface have been characterized, and found to correspond to moderately strong hydrogen bonding interactions. To gain further insight on the nature of binding, the total interaction energy was decomposed into its physically meaningful components and selected sections of the potential energy surface were calculated. Moreover, we found that H{sup -} can easily covalently bind to one of the carbon atoms of benzene to form a stable C{sub 6}H{sub 7}{sup -} anion, a global minimum on the potential energy surface, characterized by a puckered geometry, with a carbon atom bending out of the benzene plane. A slightly less stable planar C{sub 6}H{sub 7}{sup -} structure was also identified, corresponding to the transition state for the flipping motion of the puckered species.

  15. Variability of Surface pollutants and aerosol concentration over Abu Dhabi, UAE - sources, transport and current levels

    Science.gov (United States)

    Phanikumar, Devulapalli V.; Basha, Ghouse; Ouarda, Taha B. M. J.

    2015-04-01

    In the view of recent economic, industrial, and rapid development, Abu Dhabi (24.4oN; 54.4oE; 27m msl) has become one of the most populated regions in the world despite of extreme heat, frequent dust storms, and with distinctive topography. The major sources of air pollution are from the dust and sand storms, greenhouse gas emissions, and to some extent from industrial pollution. In order to realize the accurate and comprehensive understanding of air quality and plausible sources over this region, we have made a detailed analysis of three years simultaneous measurements during 2011-13 of pollutants such as O3, SO2, NO2, CO, and PM10 concentrations. Diurnal variation of meteorological parameters such as temperature and wind speed/relative humidity clearly shows daytime maximum/minimum in summer followed by pre-monsoon, post-monsoon and winter. The prevailing winds over this region are mostly from northwesterly direction (Shamal wind). Diurnal wind pattern showed a clear contrast with the majority of the wind pattern during nighttime and early morning is from the westerly/northwesterly and daytime is from southwesterly/southeasterly directions. The diurnal pattern of O3 shows minimum during 08 LT and increases thereafter reaching maximum at 17 LT and decreases during nighttime. However, the diurnal pattern of SO2 and NO2 show a peak at ~ 08 LT and dip at ~ 14 LT during all the seasons with some variability in each season. On the other hand, the diurnal pattern of CO shows a peculiar picture of elevated levels during daytime peaking at ~ 10 LT (prominent in summer and post-monsoon) followed by a sharp decrease and minimum is ~14 LT. PM10 concentration has an early morning peak at ~ 02 LT and then decreases to a minimum value at ~11 LT and again increases in the afternoon hours (maximum at ~17 LT) depicting a forenoon-afternoon asymmetry. Monthly variation of PM10 shows maximum in pre-monsoon season and minimum in winter. Our observations show the diurnal pattern of

  16. Parameters Studies on Surface Initiated Rolling Contact Fatigue of Turnout Rails by Three-Level Unreplicated Saturated Factorial Design

    Directory of Open Access Journals (Sweden)

    Xiaochuan Ma

    2018-03-01

    Full Text Available Surface initiated rolling contact fatigue (RCF, mainly characterized by cracks and material stripping, is a common type of damage to turnout rails, which can not only shorten service life of turnout but also lead to poor running safety of vehicle. The rail surface initiated RCF of turnouts is caused by a long-term accumulation, the size and distribution of which are related to the dynamic parameters of the complicated vehicle-turnout system. In order to simulate the accumulation of rail damage, some random samples of dynamic parameters significantly influencing it should be input. Based on the three-level unreplicated saturated factorial design, according to the evaluation methods of H, P and B statistic values, six dynamic parameters that influence the rail surface initiated RCF in turnouts, namely running speed of vehicle, axle load, wheel-rail profiles, integral vertical track stiffness and wheel-rail friction coefficient, are obtained by selecting 13 dynamic parameters significantly influencing the dynamic vehicle-turnout interaction as the analysis factors, considering four dynamic response results, i.e., the normal wheel-rail contact force, longitudinal creep force, lateral creep force and wheel-rail contact patch area as the observed parameters. In addition, the rail surface initiated RCF behavior in turnouts under different wheel-rail creep conditions is analyzed, considering the relative motion of stock/switch rails. The results show that the rail surface initiated RCF is mainly caused by the tangential stress being high under small creep conditions, the normal and tangential stresses being high under large creep conditions, and the normal stress being high under pure spin creep conditions.

  17. Electrochemical separation and isotopic determination of thallium at the nanogram level by surface ionisation mass spectrometry

    International Nuclear Information System (INIS)

    Arden, J.W.

    1983-01-01

    A rapid low-blank procedure is described for the co-separation of thallium and lead by sequential cathodic and anodic electrodeposition from natural samples, especially complex natural silicates, for subsequent mass spectrometry. A micro anion-exchange procedure is also described for the separation of thallium and lead. Ion currents of 10 - 10 A can be obtained from 1 ng of thallium. The isotopic composition of 1 ng of thallium can be measured on a Faraday detector with a precision of 0.05-0.1%. The total procedural blank is 3 pg. By using stable isotope dilution, 0.2 ng of thallium can be measured with a precision of 0.6% with only a 2% blank correction. This allows the accurate determination of thallium in natural samples down to concentration levels of about 50 pg g - 1 . The detection limit is 50 fg. This procedure has been applied to meteorites and terrestrial rocks. The stable isotope dilution technique is suitable for geochemical, environmental and toxicological studies requiring a highly sensitive, accurate and precise method for the determination of thallium. (Auth.)

  18. Response of groundwater level and surface-water/groundwater interaction to climate variability: Clarence-Moreton Basin, Australia

    Science.gov (United States)

    Cui, Tao; Raiber, Matthias; Pagendam, Dan; Gilfedder, Mat; Rassam, David

    2017-08-01

    Understanding the response of groundwater levels in alluvial and sedimentary basin aquifers to climatic variability and human water-resource developments is a key step in many hydrogeological investigations. This study presents an analysis of groundwater response to climate variability from 2000 to 2012 in the Queensland part of the sedimentary Clarence-Moreton Basin, Australia. It contributes to the baseline hydrogeological understanding by identifying the primary groundwater flow pattern, water-level response to climate extremes, and the resulting dynamics of surface-water/groundwater interaction. Groundwater-level measurements from thousands of bores over several decades were analysed using Kriging and nonparametric trend analysis, together with a newly developed three-dimensional geological model. Groundwater-level contours suggest that groundwater flow in the shallow aquifers shows local variations in the close vicinity of streams, notwithstanding general conformance with topographic relief. The trend analysis reveals that climate variability can be quickly reflected in the shallow aquifers of the Clarence-Moreton Basin although the alluvial aquifers have a quicker rainfall response than the sedimentary bedrock formations. The Lockyer Valley alluvium represents the most sensitively responding alluvium in the area, with the highest declining (-0.7 m/year) and ascending (2.1 m/year) Sen's slope rates during and after the drought period, respectively. Different surface-water/groundwater interaction characteristics were observed in different catchments by studying groundwater-level fluctuations along hydrogeologic cross-sections. The findings of this study lay a foundation for future water-resource management in the study area.

  19. Response of groundwater level and surface-water/groundwater interaction to climate variability: Clarence-Moreton Basin, Australia

    Science.gov (United States)

    Cui, Tao; Raiber, Matthias; Pagendam, Dan; Gilfedder, Mat; Rassam, David

    2018-03-01

    Understanding the response of groundwater levels in alluvial and sedimentary basin aquifers to climatic variability and human water-resource developments is a key step in many hydrogeological investigations. This study presents an analysis of groundwater response to climate variability from 2000 to 2012 in the Queensland part of the sedimentary Clarence-Moreton Basin, Australia. It contributes to the baseline hydrogeological understanding by identifying the primary groundwater flow pattern, water-level response to climate extremes, and the resulting dynamics of surface-water/groundwater interaction. Groundwater-level measurements from thousands of bores over several decades were analysed using Kriging and nonparametric trend analysis, together with a newly developed three-dimensional geological model. Groundwater-level contours suggest that groundwater flow in the shallow aquifers shows local variations in the close vicinity of streams, notwithstanding general conformance with topographic relief. The trend analysis reveals that climate variability can be quickly reflected in the shallow aquifers of the Clarence-Moreton Basin although the alluvial aquifers have a quicker rainfall response than the sedimentary bedrock formations. The Lockyer Valley alluvium represents the most sensitively responding alluvium in the area, with the highest declining (-0.7 m/year) and ascending (2.1 m/year) Sen's slope rates during and after the drought period, respectively. Different surface-water/groundwater interaction characteristics were observed in different catchments by studying groundwater-level fluctuations along hydrogeologic cross-sections. The findings of this study lay a foundation for future water-resource management in the study area.

  20. Performance of backfill materials in near surface disposal facilities for low and intermediate level radwaste. Appendix 4: China (a)

    International Nuclear Information System (INIS)

    Cunli, G.; Yawen, H.; Zhiwen, F.; Anxi, C.; Xiuzhen, L.; Jinsheng, Z.

    2001-01-01

    Full text: Backfill material is an important component of a multi-barriered disposal facility for low and intermediate level radioactive waste. This appendix describes the work concerning 'performance study on engineering materials of shallow land disposal of low and intermediate level radwaste'. At the time of the CRP, China had planned to establish five regional disposal sites for low-and-intermediate level radioactive waste. According to the potential distribution of these sites, forty-three sampling points were selected through information survey and table discussion. After field survey and screening, eight of them were selected for further studies in laboratory. Basic physical and chemical properties of each sample were measured in laboratory. The results indicate that no one of the samples can individually function as the backfill material in a multi-barriered near surface facility. Then nine additives for adsorption modification were tested using a static method. Further adsorption tests were conducted: three additives screened out in previous experiment were evaluated using the static method. Results obtained show that the Kd values of mixtures of 90% NW-3 and 10% BC for Co-60, Cs-134 and Sr-85, compared with those of 100% NW-3, are 4.8, 4.6 and 4.7 times higher, respectively. Effects of contact time, pH of tracer solutions and radionuclide concentrations of tracer solutions on Kd values of three samples, NW-3, BC and 90% NW-3 with 10% BC, were also be evaluated using the static method. Column tests were performed to evaluate migration of Co-60, Cs-134 and Sr-85 in NW-3 columns with different densities. The column tests were carried out for 210 days. However, no breakthrough was obtained. Long term performance of backfill materials was assessed through natural analogue. We compared Chinese ancient tombs with near-surface low and intermediate level radioactive waste (LILW) disposal facilities. Both were designed based upon multi-barrier principle. Then three

  1. Process Control Plan for Tank 241-SY-101 Surface Level Rise Remediation

    International Nuclear Information System (INIS)

    ESTEY, S.D.

    1999-01-01

    The tank 241-SY-101 transfer system was conceived and designed to address the immediate needs presented by rapidly changing waste conditions in tank 241-SY-101. Within approximately the last year, the waste in this tank has exhibited unexpected behavior (Rassat et al. 1999) in the form of rapidly increasing crust growth. This growth has been brought about by a rapidly increasing rate of gas entrapment within the crust. It has been conceived that the lack of crust agitation beginning upon the advent of mixer pump operations may have set-up a more consolidated, gas impermeable barrier when compared to a crust regularly broken up by the prior buoyant displacement events within the tank. The interim goals of the project are to: (1) protect the mixer pump operability (2) begin releasing gas from the crust, and (3) begin dissolving the crust and solids in the slurry layer. The final goals of the project (Final State) are to solve both the level growth and BD-GRE safety issues in this tank by achieving a condition of the waste such that no active measures are required to safely store the waste, i.e., crust and non convective layer are mostly dissolved, and therefore the mixer pump will no longer be needed to prevent BD-GREs in excess of 100% LFL. Transfers (which are designed to create space in the tank) and dilution (which will dissolve the solids) will accomplish this. Dissolution of solids will result in a release of gas retained by those solids and remove that volume of solids as a future retention site

  2. Surface gas pollutants in Lhasa, a highland city of Tibet: current levels and pollution implications

    Science.gov (United States)

    Ran, L.; Lin, W. L.; Deji, Y. Z.; La, B.; Tsering, P. M.; Xu, X. B.; Wang, W.

    2014-05-01

    Through several years of development, the city of Lhasa has become one of the most populated and urbanized areas on the highest plateau in the world. In the process of urbanization, current and potential air quality issues have been gradually concerned. To investigate the current status of air pollution in Lhasa, various gas pollutants including NOx, CO, SO2 and O3 were continuously measured from June 2012 to May 2013 at an urban site (29.40° N, 91.08° E, 3650 m a.s.l.). The seasonal variations of primary gas pollutants exhibited a peak from November to January with a large variability. High concentrations of primary trace gases almost exclusively occurred under low wind speed and showed no distinct dependence on wind direction, implying local urban emissions to be predominant. A comparison of NO2, CO and SO2 concentrations in summer between 1998 and 2012 indicated a significant increase in emissions of these gas pollutants and a change in their intercorrelations, as a result of a substantial growth in the demand of energy consumption using fossil fuels instead of previously widely used biofuels. The pronounced diurnal double peaks of primary trace gases in all seasons suggested automobile exhaust to be a major emission source in Lhasa. The secondary gas pollutant O3 displayed an average diurnal cycle of a shallow flat peak for about 4-5 h in the afternoon and a minimum in the early morning. Nighttime O3 was sometimes completely consumed by the high level of NOx. Seasonally, the variations of O3 concentrations displayed a low valley in winter and a peak in spring. In autumn and winter, transport largely contributed to the observed O3 concentrations, given its dependence on wind speed and wind direction, while in spring and summer photochemistry played an important role. A more efficient buildup of O3 concentrations in the morning and a higher peak in the afternoon was found in summer 2012 than in 1998. An enhancement in O3 concentrations would be expected in the

  3. Surface gas pollutants in Lhasa, a highland city of Tibet - current levels and pollution implications

    Science.gov (United States)

    Ran, L.; Lin, W. L.; Deji, Y. Z.; La, B.; Tsering, P. M.; Xu, X. B.; Wang, W.

    2014-10-01

    Through several years of development, the city of Lhasa has become one of the most populated and urbanized areas on the highest plateau in the world. In the process of urbanization, current and potential air quality issues have been gradually concerned. To investigate the current status of air pollution in Lhasa, various gas pollutants including NOx, CO, SO2, and O3, were continuously measured from June 2012 to May 2013 at an urban site (29.40° N, 91.08° E, 3650 m a.s.l.). The seasonal variations of primary gas pollutants exhibited a peak from November to January with a large variability. High mixing ratios of primary trace gases almost exclusively occurred under low wind speed and showed no distinct dependence on wind direction, implying local urban emissions to be predominant. A comparison of NO2, CO, and SO2 mixing ratios in summer between 1998 and 2012 indicated a significant increase in emissions of these gas pollutants and a change in their intercorrelations, as a result of a substantial growth in the demand of energy consumption using fossil fuels instead of previously widely used biomass. The pronounced diurnal double peaks of primary trace gases in all seasons suggested automobile exhaust to be a major emission source in Lhasa. The secondary gas pollutant O3 displayed an average diurnal cycle of a shallow flat peak for about 4-5 h in the afternoon and a minimum in the early morning. Nighttime O3 was sometimes completely consumed by the high level of NOx. Seasonally, the variations of O3 mixing ratios displayed a low valley in winter and a peak in spring. In autumn and winter, transport largely contributed to the observed O3 mixing ratios, given its dependence on wind speed and wind direction, while in spring and summer photochemistry played an important role. A more efficient buildup of O3 mixing ratios in the morning and a higher peak in the afternoon was found in summer 2012 than in 1998. An enhancement in O3 mixing ratios would be expected in the

  4. Carbon Monoxide, Nitric Oxide, and Nitrogen Dioxide Levels in Gas Ovens Related to Surface Pinking of Cooked Beef and Turkey.

    Science.gov (United States)

    Cornforth; Rabovitser; Ahuja; Wagner; Hanson; Cummings; Chudnovsky

    1998-01-19

    Carbon monoxide (CO) and total nitrogen oxide (NO(x)()) levels were monitored during meat cookery with a standard Ovenpak and a new ultralow-NO(x)() (ULN) cyclonic gas burner. With the standard burner, CO varied from 103 to 152 ppm, NO(x)() was 1.3-10.7 ppm, and surface pinking was observed on both beef and turkey. The ULN burner at optimal efficiency produced only 6.7 ppm of CO and 1 ppm of NO(x)(), insufficient to cause surface pinking. To determine the relative contribution of CO and NO(x)() to pinking, trials were also conducted in an electric oven with various pure gases. Pinking was not observed with up to 149 ppm of CO or 5 ppm of NO. However, as little as 0.4 ppm of nitrogen dioxide (NO(2)) caused pinking of turkey rolls. Beef roasts were pink at >2.5 ppm of NO(2). Thus, pinking previously attributed to CO and NO in gas ovens is instead due to NO(2), which has much greater reactivity than NO with moisture at meat surfaces.

  5. Evidence of antibacterial activity on titanium surfaces through nanotextures

    Science.gov (United States)

    Seddiki, O.; Harnagea, C.; Levesque, L.; Mantovani, D.; Rosei, F.

    2014-07-01

    Nosocomial infections (Nis) are a major concern for public health. As more and more of the pathogens responsible for these infections are antibiotic resistant, finding new ways to overcome them is a major challenge for biomedical research. We present a method to reduce Nis spreading by hindering bacterial adhesion in its very early stage. This is achieved by reducing the contact interface area between the bacterium and the surface by nanoengineering the surface topography. In particular, we studied the Escheria Coli adhesion on titanium surfaces exhibiting different morphologies, that were obtained by a combination of mechanical polishing and chemical etching. Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM) characterization revealed that the titanium surface is modified at both micro- and nano-scale. X-ray Photoelectron Spectroscopy (XPS) revealed that the surfaces have the same composition before and after piranha treatment, consisting mainly of TiO2. Adhesion tests showed a significant reduction in bacterial accumulation on nanostructured surfaces that had the lowest roughness over large areas. SEM images acquired after bacterial culture on different titanium substrates confirmed that the polished titanium surface treated one hour in a piranha solution at a temperature of 25 °C has the lowest bacterial accumulation among all the surfaces tested. This suggests that the difference observed in bacterial adhesion between the different surfaces is due primarily to surface topography.

  6. Evidence of antibacterial activity on titanium surfaces through nanotextures

    International Nuclear Information System (INIS)

    Seddiki, O.; Harnagea, C.; Levesque, L.; Mantovani, D.; Rosei, F.

    2014-01-01

    Nosocomial infections (Nis) are a major concern for public health. As more and more of the pathogens responsible for these infections are antibiotic resistant, finding new ways to overcome them is a major challenge for biomedical research. We present a method to reduce Nis spreading by hindering bacterial adhesion in its very early stage. This is achieved by reducing the contact interface area between the bacterium and the surface by nanoengineering the surface topography. In particular, we studied the Escheria Coli adhesion on titanium surfaces exhibiting different morphologies, that were obtained by a combination of mechanical polishing and chemical etching. Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM) characterization revealed that the titanium surface is modified at both micro- and nano-scale. X-ray Photoelectron Spectroscopy (XPS) revealed that the surfaces have the same composition before and after piranha treatment, consisting mainly of TiO 2 . Adhesion tests showed a significant reduction in bacterial accumulation on nanostructured surfaces that had the lowest roughness over large areas. SEM images acquired after bacterial culture on different titanium substrates confirmed that the polished titanium surface treated one hour in a piranha solution at a temperature of 25 °C has the lowest bacterial accumulation among all the surfaces tested. This suggests that the difference observed in bacterial adhesion between the different surfaces is due primarily to surface topography.

  7. Evidence of antibacterial activity on titanium surfaces through nanotextures

    Energy Technology Data Exchange (ETDEWEB)

    Seddiki, O.; Harnagea, C. [INRS – Centre Énergie, Matériaux et Télécommunications, Boulevard Lionel-Boulet, Varennes, Québec J3X 1S2 (Canada); Levesque, L.; Mantovani, D. [Laboratory for Biomaterials and Bioengineering (CRC-I), Dept Min-Met-Materials Engineering and Research Center CHU-Quebec, Laval University, Quebec City (Canada); Rosei, F., E-mail: rosei@emt.inrs.ca [INRS – Centre Énergie, Matériaux et Télécommunications, Boulevard Lionel-Boulet, Varennes, Québec J3X 1S2 (Canada); Center for Self-Assembled Chemical Structures, McGill University, H3A 2K6 Montreal, Quebec (Canada)

    2014-07-01

    Nosocomial infections (Nis) are a major concern for public health. As more and more of the pathogens responsible for these infections are antibiotic resistant, finding new ways to overcome them is a major challenge for biomedical research. We present a method to reduce Nis spreading by hindering bacterial adhesion in its very early stage. This is achieved by reducing the contact interface area between the bacterium and the surface by nanoengineering the surface topography. In particular, we studied the Escheria Coli adhesion on titanium surfaces exhibiting different morphologies, that were obtained by a combination of mechanical polishing and chemical etching. Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM) characterization revealed that the titanium surface is modified at both micro- and nano-scale. X-ray Photoelectron Spectroscopy (XPS) revealed that the surfaces have the same composition before and after piranha treatment, consisting mainly of TiO{sub 2}. Adhesion tests showed a significant reduction in bacterial accumulation on nanostructured surfaces that had the lowest roughness over large areas. SEM images acquired after bacterial culture on different titanium substrates confirmed that the polished titanium surface treated one hour in a piranha solution at a temperature of 25 °C has the lowest bacterial accumulation among all the surfaces tested. This suggests that the difference observed in bacterial adhesion between the different surfaces is due primarily to surface topography.

  8. The status of pesticide pollution in surface waters (rivers and lakes) of Greece. Part I. Review on occurrence and levels

    International Nuclear Information System (INIS)

    Konstantinou, Ioannis K.; Hela, Dimitra G.; Albanis, Triantafyllos A.

    2006-01-01

    This review evaluates and summarizes the results of long-term research projects, monitoring programs and published papers concerning the pollution of surface waters (rivers and lakes) of Greece by pesticides. Pesticide classes mostly detected involve herbicides used extensively in corn, cotton and rice production, organophosphorus insecticides as well as the banned organochlorines insecticides due to their persistence in the aquatic environment. The compounds most frequently detected were atrazine, simazine, alachlor, metolachlor and trifluralin of the herbicides, diazinon, parathion methyl of the insecticides and lindane, endosulfan and aldrin of the organochlorine pesticides. Rivers were found to be more polluted than lakes. The detected concentrations of most pesticides follow a seasonal variation, with maximum values occurring during the late spring and summer period followed by a decrease during winter. Nationwide, in many cases the reported concentrations ranged in low ppb levels. However, elevated concentrations were recorded in areas of high pesticide use and intense agricultural practices. Generally, similar trends and levels of pesticides were found in Greek rivers compared to pesticide contamination in other European rivers. Monitoring of the Greek water resources for pesticide residues must continue, especially in agricultural regions, because the nationwide patterns of pesticide use are constantly changing. Moreover, emphasis should be placed on degradation products not sufficiently studied so far. - Information on pesticide pollution of surface waters in Greece is reviewed

  9. On the effect of different aerosol types on surface solar radiation levels over the region of Eastern Mediterranean

    Science.gov (United States)

    Alexandri, Georgia; Georgoulias, Aristeidis K.; Kourtidis, Konstantinos; Meleti, Charikleia; Balis, Dimitris

    2014-05-01

    In this work, we examine the direct effect of different aerosol types on the surface solar radiation (SSR) levels in the region of Eastern Mediterranean. Simulations with the Santa Barbara DISORT Atmospheric Radiative Transfer (SBDART) model were performed using ground and satellite-based data as input. An IDL tool that "feeds" SBDART with the appropriate input data was developed allowing us to simulate SSR with a time step of 1 hour. Level-2 aerosol optical depth, cloud optical depth, cloud fraction, effective droplet radius, cloud top pressure, precipitable water and surface albedo data from MODIS, as well as ozone total column data from Earth Probe TOMS and OMI satellite sensors, coarse resolution cloud data from the ISCCP and single scattering albedo, asymmetry factor and Angström exponent sunphotometric data from the AERONET are used in our radiative transfer simulations. Simulations are performed over selected spots within Eastern Mediterranean for clear, liquid cloud and ice cloud covered skies and for different aerosol types (maritime, dust, anthropogenic, fine-mode natural). The optical properties of aerosols were determined using a combination of satellite, ground-based, model and reanalysis products. The aerosol direct radiative effect is defined as the difference between simulations done with and without the presence of aerosols. This research has been financed by EPAN II and PEP under the national action "Bilateral, multilateral and regional R&T cooperations" (AEROVIS Sino-Greek project).

  10. Surface elevation change and susceptibility of different mangrove zones to sea-level rise on Pacific high islands of Micronesia

    Science.gov (United States)

    Krauss, K.W.; Cahoon, D.R.; Allen, J.A.; Ewel, K.C.; Lynch, J.C.; Cormier, N.

    2010-01-01

    Mangroves on Pacific high islands offer a number of important ecosystem services to both natural ecological communities and human societies. High islands are subjected to constant erosion over geologic time, which establishes an important source of terrigeneous sediment for nearby marine communities. Many of these sediments are deposited in mangrove forests and offer mangroves a potentially important means for adjusting surface elevation with rising sea level. In this study, we investigated sedimentation and elevation dynamics of mangrove forests in three hydrogeomorphic settings on the islands of Kosrae and Pohnpei, Federated States of Micronesia (FSM). Surface accretion rates ranged from 2.9 to 20.8 mm y-1, and are high for naturally occurring mangroves. Although mangrove forests in Micronesian high islands appear to have a strong capacity to offset elevation losses by way of sedimentation, elevation change over 61/2 years ranged from -3.2 to 4.1 mm y-1, depending on the location. Mangrove surface elevation change also varied by hydrogeomorphic setting and river, and suggested differential, and not uniformly bleak, susceptibilities among Pacific high island mangroves to sea-level rise. Fringe, riverine, and interior settings registered elevation changes of -1.30, 0.46, and 1.56 mm y-1, respectively, with the greatest elevation deficit (-3.2 mm y-1) from a fringe zone on Pohnpei and the highest rate of elevation gain (4.1 mm y-1) from an interior zone on Kosrae. Relative to sea-level rise estimates for FSM (0.8-1.8 mm y-1) and assuming a consistent linear trend in these estimates, soil elevations in mangroves on Kosrae and Pohnpei are experiencing between an annual deficit of 4.95 mm and an annual surplus of 3.28 mm. Although natural disturbances are important in mediating elevation gain in some situations, constant allochthonous sediment deposition probably matters most on these Pacific high islands, and is especially helpful in certain hydrogeomorphic zones

  11. Decreased blood hepatitis B surface antibody levels linked to e-waste lead exposure in preschool children

    International Nuclear Information System (INIS)

    Xu, Xijin; Chen, Xiaojuan; Zhang, Jian; Guo, Pi; Fu, Tingzao; Dai, Yifeng; Lin, Stanley L.; Huo, Xia

    2015-01-01

    Highlights: • Secondary exploratory analyses displayed a correlation of blood Pb to HBsAb levels. • Generalized linear mixed models were used to analyze two-phase data. • Children from an e-waste area had higher blood Pb levels and lower HBsAb titers. • Nearly 50% of Pb-exposed children fail to develop sufficient HBV immunity. • Different vaccination strategies are required for in e-waste areas. - Abstract: Lead (Pb) is a widespread environmental contaminant that can profoundly affect the immune system in vaccinated children. To explore the association between blood Pb and HBsAb levels in children chronically exposed to Pb, we measured hepatitis B surface antibody (HBsAb) titers, to reflect the immune response in the children of Guiyu, an electronic and electrical waste (e-waste) recycling area well known for environmental Pb contamination. We performed secondary exploratory analyses of blood Pb levels and plasma HBsAb titers in samples, taken in two phases between 2011 and 2012, from 590 children from Guiyu (exposed group) and Haojiang (reference group). Children living in the exposed area had higher blood Pb levels and lower HBsAb titers compared with children from the reference area. At each phase, generalized linear mixed models (GLMMs) showed that HBsAb titers were significantly negatively associated with child blood Pb levels. This work shows that a decreased immune response to hepatitis B vaccine and immune system might have potential harm to children with chronic Pb exposure. Importantly, nearly 50% of chronically exposed children failed to develop sufficient immunity to hepatitis in response to vaccination. Thus different vaccination strategies are needed for children living under conditions of chronic Pb exposure

  12. Decreased blood hepatitis B surface antibody levels linked to e-waste lead exposure in preschool children

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Xijin [Laboratory of Environmental Medicine and Developmental Toxicology, and Guangdong Provincial Key Laboratory of Infectious Diseases, Shantou University Medical College, Shantou 515041, Guangdong (China); Department of Cell Biology and Genetics, Shantou University Medical College, Shantou 515041, Guangdong (China); Chen, Xiaojuan; Zhang, Jian [Laboratory of Environmental Medicine and Developmental Toxicology, and Guangdong Provincial Key Laboratory of Infectious Diseases, Shantou University Medical College, Shantou 515041, Guangdong (China); Guo, Pi [Department of Public Health, Shantou University Medical College, Shantou 515041, Guangdong (China); Fu, Tingzao; Dai, Yifeng [Laboratory of Environmental Medicine and Developmental Toxicology, and Guangdong Provincial Key Laboratory of Infectious Diseases, Shantou University Medical College, Shantou 515041, Guangdong (China); Lin, Stanley L. [Department of Pathophysiology and Key Immunopathology Laboratory of Guangdong Province, Shantou University Medical College, Shantou 515041, Guangdong (China); Huo, Xia, E-mail: xhuo@stu.edu.cn [Laboratory of Environmental Medicine and Developmental Toxicology, and Guangdong Provincial Key Laboratory of Infectious Diseases, Shantou University Medical College, Shantou 515041, Guangdong (China)

    2015-11-15

    Highlights: • Secondary exploratory analyses displayed a correlation of blood Pb to HBsAb levels. • Generalized linear mixed models were used to analyze two-phase data. • Children from an e-waste area had higher blood Pb levels and lower HBsAb titers. • Nearly 50% of Pb-exposed children fail to develop sufficient HBV immunity. • Different vaccination strategies are required for in e-waste areas. - Abstract: Lead (Pb) is a widespread environmental contaminant that can profoundly affect the immune system in vaccinated children. To explore the association between blood Pb and HBsAb levels in children chronically exposed to Pb, we measured hepatitis B surface antibody (HBsAb) titers, to reflect the immune response in the children of Guiyu, an electronic and electrical waste (e-waste) recycling area well known for environmental Pb contamination. We performed secondary exploratory analyses of blood Pb levels and plasma HBsAb titers in samples, taken in two phases between 2011 and 2012, from 590 children from Guiyu (exposed group) and Haojiang (reference group). Children living in the exposed area had higher blood Pb levels and lower HBsAb titers compared with children from the reference area. At each phase, generalized linear mixed models (GLMMs) showed that HBsAb titers were significantly negatively associated with child blood Pb levels. This work shows that a decreased immune response to hepatitis B vaccine and immune system might have potential harm to children with chronic Pb exposure. Importantly, nearly 50% of chronically exposed children failed to develop sufficient immunity to hepatitis in response to vaccination. Thus different vaccination strategies are needed for children living under conditions of chronic Pb exposure.

  13. The role of surface and subsurface processes in keeping pace with sea level rise in intertidal wetlands of Moreton Bay, Queensland, Australia

    Science.gov (United States)

    Lovelock, Catherine E.; Bennion, Vicki; Grinham, Alistair; Cahoon, Donald R.

    2011-01-01

    Increases in the elevation of the soil surfaces of mangroves and salt marshes are key to the maintenance of these habitats with accelerating sea level rise. Understanding the processes that give rise to increases in soil surface elevation provides science for management of landscapes for sustainable coastal wetlands. Here, we tested whether the soil surface elevation of mangroves and salt marshes in Moreton Bay is keeping up with local rates of sea level rise (2.358 mm y-1) and whether accretion on the soil surface was the most important process for keeping up with sea level rise. We found variability in surface elevation gains, with sandy areas in the eastern bay having the highest surface elevation gains in both mangrove and salt marsh (5.9 and 1.9 mm y-1) whereas in the muddier western bay rates of surface elevation gain were lower (1.4 and -0.3 mm y-1 in mangrove and salt marsh, respectively). Both sides of the bay had similar rates of surface accretion (~7–9 mm y-1 in the mangrove and 1–3 mm y-1 in the salt marsh), but mangrove soils in the western bay were subsiding at a rate of approximately 8 mm y-1, possibly due to compaction of organic sediments. Over the study surface elevation increments were sensitive to position in the intertidal zone (higher when lower in the intertidal) and also to variation in mean sea level (higher at high sea level). Although surface accretion was the most important process for keeping up with sea level rise in the eastern bay, subsidence largely negated gains made through surface accretion in the western bay indicating a high vulnerability to sea level rise in these forests.

  14. NiS and MoS2 nanosheet co-modified graphitic C3N4 ternary heterostructure for high efficient visible light photodegradation of antibiotic.

    Science.gov (United States)

    Lu, Xuejun; Wang, Yu; Zhang, Xinyi; Xu, Guangqing; Wang, Dongmei; Lv, Jun; Zheng, Zhixiang; Wu, Yucheng

    2018-01-05

    The development of efficient solar driven catalytic system for the degradation of antibiotics has become increasingly important in environmental protection and remediation. Non-noble-metal NiS and MoS 2 nanosheet co-modified graphitic C 3 N 4 ternary heterostructure has been synthesized via a facile combination of hydrothermal and ultrasound method, and the ternary heterostructure has been utilized for photocatalytic degradation of antibiotic agents. The antibiotics of ciprofloxacin (CIP) and tetracycline hydrochloride (TC) were photodegraded by the hybrid under the visible light. The optimal photodegradation rate of the ternary heterostructure reaches about 96% after 2h irradiation, which is 2.1 times higher than that of pure g-C 3 N 4 for TC degradation. The photocatalytic degradation rates of the ternary heterostructure for both CIP and TC obey the pseudo-first-order kinetic model. The enhanced visible light adsorption and charge separation efficiency contribute to the photocatalytic performance of the ternary heterostructure. This work provides new insights and pathways by which efficient degradation of antibiotics can be achieved and will stimulate further studies in this important field. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. Allotment plan as a condition for sustainable development on the example of detailed regulation 'Stanko Vlasotinčanin' in Nis

    Directory of Open Access Journals (Sweden)

    Obradović Tanja

    2012-01-01

    Full Text Available In order to protect the environment and creation the conditions for a good and healthy life, the construction of buildings should be sustainable. It is essential that the entire process that includes planning, design and realization, be consistent with bioclimatic principles. Allotment plan should be an integral part of the planning process because it is an instrument to control the use of construction land and prevention the negative consequences that are created by uncontrolled action of the market. This paper analyzes the detailed regulation plan, 'Stanko Vlasotinčanin' in Nis with emphasis on the lack of plan allotment and (non application of bioclimatic principles in the planning. Performs a comparison with the detailed planning before 2003, ie. before the Law on planning and construction. Analyses the legislation relating to land use. Recommendations for amending the same, and the introduction of urban consolidation as a possible model of land development and implementation of spatial planning. It is concluded that it is necessary to undertake a number of different measures that are primarily related to the amendment and enforcement of legislation, the introduction of assessment of market value of land and the involvement and the willingness of experts and institutions for their implementation.

  16. Evaluation of pH Levels and Surface Roughness After Bleaching and Abrasion Tests of Eight Commercial Products.

    Science.gov (United States)

    Trentino, Ana Carolina; Soares, Ana Flavia; Duarte, Marco Antonio Hungaro; Ishikiriama, Sérgio Kiyoshi; Mondelli, Rafael Francisco Lia

    2015-07-01

    This in vitro study evaluated the effect of different bleaching protocols and the variation of pH levels of bleaching gels regarding roughness and wear of bovine enamel, after in-office bleaching protocols and brushing. Ninety fragments were randomly divided into nine groups: C, control; WHP15, 35% hydrogen peroxide (HP) (Whiteness HP, FGM) three gel applications of 15 min each, three sessions with 1 week intervals; WHP45, 35% HP (Whiteness HP) one application/45 min, three sessions with 1 week intervals; LPS, 35% HP (Lase Peroxide, DMC) plus hybrid light (HL) [light-emitting diode (LED)/diode laser], four applications/7 min 30 sec (6 min of HL activation), one session; LPSII, 25% HP (Lase Peroxide II, DMC) plus HL, four applications/7 min 30 sec (6 min of HL activation), one session; LPL, 15% HP (Lase Peroxide Light, DMC) four applications/7 min 30 sec (6 min of HL activation), one session; WO, 35% HP (Whitegold Office, Dentsply) three applications/15 min, three sessions with 1 week intervals; WBC40, 35% HP (Whiteness HP Blue Calcium, FGM) one application/40 min, three sessions with 1 week intervals; and WBC50, 20% HP (Whiteness HP Blue Calcium) one application/50 min, three sessions with 1 week intervals. The median pH values were determined utilizing a pH meter during the initial and final gel applications. A rugosimeter was utilized to evaluate the surface roughness (Ra) before and after bleaching and brushing (100,000 strokes), and the surface wear after brushing. For the results of the pH values, there was a decrease in the pH levels from the initial to the final bleaching time, except for the WBC50. The WO and WBC40 groups exhibited higher pH values. For the results of roughness and wear, there was an increase in surface roughness and wear among the groups. The pH values tended to decrease from the initial to the final bleaching. After tooth brushing, bleaching procedures with lower pH products provided a significant increase in

  17. Earth-abundant NiS co-catalyst modified metal-free mpg-C3N4/CNT nanocomposites for highly efficient visible-light photocatalytic H2 evolution.

    Science.gov (United States)

    Zhong, Yongming; Yuan, Jielin; Wen, Jiuqing; Li, Xin; Xu, Yuehua; Liu, Wei; Zhang, Shengsen; Fang, Yueping

    2015-11-07

    In the present work, the earth-abundant NiS co-catalyst modified mesoporous graphite-like C3N4 (mpg-C3N4)/CNT nanocomposites were prepared via a two-step strategy: the sol-gel method and the direct precipitation process. The mpg-C3N4/CNT/NiS composite photocatalysts were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), UV-vis absorption spectroscopy, photoluminescence spectroscopy (PL), photoelectrochemical (PEC) and electrochemical impedance spectra (EIS) experiments. The photocatalytic H2-production activity over the composite catalysts was also evaluated by using an aqueous solution containing triethanolamine under visible light (λ≥ 420 nm). The results showed that the loading of earth-abundant NiS co-catalysts onto metal-free mpg-C3N4/CNT nanocomposites can remarkably enhance their photocatalytic H2-production activity. The optimal loading amount of NiS on metal-free mpg-C3N4/CNT nanocomposites was about 1 wt%. The as-obtained mpg-C3N4/CNT/1% NiS ternary composite photocatalyst exhibits the best H2-evolution activity with the highest rate of about 521 μmol g(-1) h(-1) under visible light (λ≥ 420 nm), which is almost 148 times that of a pure mpg-C3N4/CNT sample. The enhanced photocatalytic activity can be mainly attributed to the synergistic effect of effectively promoted separation of photo-generated electron-hole pairs and enhanced H2-evolution kinetics. The co-loading of nanocarbon materials and earth-abundant co-catalysts onto metal-free mpg-C3N4 photocatalysts offers great potential for practical applications in photocatalytic H2 evolution under visible light illumination.

  18. Surface aerosol and rehabilitation properties of ground-level atmosphere in the mountains of the North Caucasus

    Science.gov (United States)

    Reps, Valentina; Efimenko, Natalia; Povolotskaya, Nina; Abramtsova, Anna; Ischenko, Dmitriy; Senik, Irina; Slepikh, Victor

    2017-04-01

    The rehabilitative properties (RP) of ground-level atmosphere (GA) of Russian resorts are considered as natural healing resources and received state legal protection [1]. Due to global urbanization the chemical composition and particle size distribution of the surface aerosol are changing rapidly. However, the influence of surface aerosol on the RP of GA has been insufficiently studied. At the resort region of the North Caucasus complex monitoring (aerosol, trace gases NOx, CO, O3, CH4; periodically - heavy metals) is performed at two high levels (860 masl - a park zone of a large mountain resort, 2070 masl - alpine grassland, the net station). The results of the measurements are used in programs of bioclimatic, landscape and medical monitoring to specify the influence of aerosol on rehabilitation properties of the environment and human adaptative reserves. The aerosol particles of size range 500-1000 nm are used as a marker of the pathogenic effect of aerosol [2]. In the conditions of regional urbanization and complicated mountain atmospheric circulation the influence of aerosol on RP of GA and the variability of heart rhythm with the volunteers at different heights were investigated. At the height of 860 masl (urbanized resort) there have been noticed aerosol variations in the range of 0,04-0,35 particles/cm3 (slightly aerosol polluted), in mountain conditions - background pollution aerosol level. The difference of bioclimatic conditions at the specified high-rise levels has been referred to the category of contrasts. The natural aero ionization ∑(N+)+(N-) varied from 960 ion/cm3 to 1460 ion/cm3 in the resort park (860 m); from 1295 ion/cm3 to 4850 ion/cm3 on the Alpine meadow (2070 m); from 1128 ion/cm3 to 3420 ion/cm3 - on the tested site near the edge of the pinewood (1720 m). In the group of volunteers the trip from low-hill terrain zone (860 m) to the lower zone of highlands (2070 m) caused the activation of neuro and humoral regulation, vegetative and

  19. High hepatitis B surface antigen levels predict insignificant fibrosis in hepatitis B e antigen positive chronic hepatitis B.

    Directory of Open Access Journals (Sweden)

    Wai-Kay Seto

    Full Text Available INTRODUCTION: There is no data on the relationship between hepatitis B surface antigen (HBsAg levels and liver fibrosis in hepatitis B e antigen (HBeAg-positive patients with chronic hepatitis B (CHB. METHODS: Serum HBsAg and HBV DNA levels in HBeAg-positive CHB patients with liver biopsies were analyzed. The upper limit of normal (ULN of alanine aminotransferase (ALT was 30 and 19 U/L for men and women respectively. Histologic assessment was based on Ishak fibrosis staging for fibrosis and Knodell histologic activity index (HAI for necroinflammation. RESULTS: 140 patients (65% male, median age 32.7 years were recruited. 56 (40% had ALT ≤2×ULN. 72 (51.4% and 42 (30% had fibrosis score ≤ 1 and necroinflammation grading ≤ 4 respectively. Patients with fibrosis score ≤ 1, when compared to patients with fibrosis score >1, had significantly higher median HBsAg levels (50,320 and 7,820 IU/mL respectively, p<0.001. Among patients with ALT ≤2×ULN, serum HBsAg levels achieved an area under receiver operating characteristic curve of 0.869 in predicting fibrosis score ≤ 1. HBsAg levels did not accurately predict necroinflammation score. HBsAg ≥ 25,000 IU/mL was independently associated with fibrosis score ≤ 1 (p=0.025, odds ratio 9.042.Using this cut-off HBsAg level in patients with ALT ≤2×ULN, positive and negative predictive values for predicting fibrosis score ≤ 1 were 92.7% and 60.0% respectively. HBV DNA levels had no association with liver histology. CONCLUSION: Among HBeAg-positive patients with ALT ≤2×ULN, high serum HBsAg levels can accurately predict fibrosis score ≤ 1, and could potentially influence decisions concerning treatment commencement and reduce the need for liver biopsy.

  20. Features, events, processes, and safety factor analysis applied to a near-surface low-level radioactive waste disposal facility

    Energy Technology Data Exchange (ETDEWEB)

    Stephens, M.E.; Dolinar, G.M.; Lange, B.A. [Atomic Energy of Canada Limited, Ontario (Canada)] [and others

    1995-12-31

    An analysis of features, events, processes (FEPs) and other safety factors was applied to AECL`s proposed IRUS (Intrusion Resistant Underground Structure) near-surface LLRW disposal facility. The FEP analysis process which had been developed for and applied to high-level and transuranic disposal concepts was adapted for application to a low-level facility for which significant efforts in developing a safety case had already been made. The starting point for this process was a series of meetings of the project team to identify and briefly describe FEPs or safety factors which they thought should be considered. At this early stage participants were specifically asked not to screen ideas. This initial list was supplemented by selecting FEPs documented in other programs and comments received from an initial regulatory review. The entire list was then sorted by topic and common issues were grouped, and issues were classified in three priority categories and assigned to individuals for resolution. In this paper, the issue identification and resolution process will be described, from the initial description of an issue to its resolution and inclusion in the various levels of the safety case documentation.

  1. Ab initio potential energy surface and vibration-rotation energy levels of silicon dicarbide, SiC2.

    Science.gov (United States)

    Koput, Jacek

    2016-10-05

    The accurate ground-state potential energy surface of silicon dicarbide, SiC2 , has been determined from ab initio calculations using the coupled-cluster approach. Results obtained with the conventional and explicitly correlated coupled-cluster methods were compared. The core-electron correlation, higher-order valence-electron correlation, and scalar relativistic effects were taken into account. The potential energy barrier to the linear SiCC configuration was predicted to be 1782 cm(-1) . The vibration-rotation energy levels of the SiC2 , (29) SiC2 , (30) SiC2 , and SiC(13) C isotopologues were calculated using a variational method. The experimental vibration-rotation energy levels of the main isotopologue were reproduced to high accuracy. In particular, the experimental energy levels of the highly anharmonic vibrational ν3 mode of SiC2 were reproduced to within 6.7 cm(-1) , up to as high as the v3  = 16 state. © 2016 Wiley Periodicals, Inc.

  2. Soil Moisture Active Passive (SMAP) Mission Level 4 Surface and Root Zone Soil Moisture (L4_SM) Product Specification Document

    Science.gov (United States)

    Reichle, Rolf H.; Ardizzone, Joseph V.; Kim, Gi-Kong; Lucchesi, Robert A.; Smith, Edmond B.; Weiss, Barry H.

    2015-01-01

    This is the Product Specification Document (PSD) for Level 4 Surface and Root Zone Soil Moisture (L4_SM) data for the Science Data System (SDS) of the Soil Moisture Active Passive (SMAP) project. The L4_SM data product provides estimates of land surface conditions based on the assimilation of SMAP observations into a customized version of the NASA Goddard Earth Observing System, Version 5 (GEOS-5) land data assimilation system (LDAS). This document applies to any standard L4_SM data product generated by the SMAP Project. The Soil Moisture Active Passive (SMAP) mission will enhance the accuracy and the resolution of space-based measurements of terrestrial soil moisture and freeze-thaw state. SMAP data products will have a noteworthy impact on multiple relevant and current Earth Science endeavors. These include: Understanding of the processes that link the terrestrial water, the energy and the carbon cycles, Estimations of global water and energy fluxes over the land surfaces, Quantification of the net carbon flux in boreal landscapes Forecast skill of both weather and climate, Predictions and monitoring of natural disasters including floods, landslides and droughts, and Predictions of agricultural productivity. To provide these data, the SMAP mission will deploy a satellite observatory in a near polar, sun synchronous orbit. The observatory will house an L-band radiometer that operates at 1.40 GHz and an L-band radar that operates at 1.26 GHz. The instruments will share a rotating reflector antenna with a 6 meter aperture that scans over a 1000 km swath.

  3. Relation between Mesophyll Surface Area, Photosynthetic Rate, and Illumination Level during Development for Leaves of Plectranthus parviflorus Henckel 1

    Science.gov (United States)

    Nobel, Park S.; Zaragoza, Lawrence J.; Smith, William K.

    1975-01-01

    The influence of illumination level during leaf development on the mesophyll cell surface area per unit leaf area (Ames/A), CO2 resistances, and the photosynthetic rate was determined for leaves of Plectranthus parviflorus Henckel. The relative importance of Ames/A versus CO2 resistances in accounting for observed changes in photosynthesis was quantitatively evaluated using equations based on analogies to electrical circuits. When the illumination during development was raised from 900 to 42,000 lux, the leaves more than tripled in thickness as the mesophyll cells increased in size and frequency, which caused Ames/A to go from 11 to 50. The net rate of photosynthesis at light saturation concomitantly increased 4-fold, reflecting a corresponding decrease in the total resistance for CO2 movement per unit leaf area. However, the CO2 resistance per unit area of mesophyll cells remained about 580 seconds per centimeter for leaves grown under 900 to 42,000 lux. Thus, for P. parviflorus, the increased photosynthetic rate for leaves developing under higher illuminations resulted from a higher Ames/A, not from changes in the CO2 resistances within individual mesophyll cells, expressed per unit area of cell surface. Results are discussed in terms of previously observed increases in thickness, internal leaf area, and photosynthetic rates for sun versus shade leaves on various plant species. PMID:16659211

  4. Ab initio potential energy surface and vibration-rotation energy levels of germanium dicarbide, GeC2.

    Science.gov (United States)

    Koput, Jacek

    2018-03-05

    The accurate ground-state potential energy surface of germanium dicarbide, GeC 2 , has been determined from ab initio calculations using the coupled-cluster approach. The core-electron correlation, higher-order valence-electron correlation, and scalar relativistic effects were taken into account. The potential energy surface of GeC 2 was shown to be extraordinarily flat near the T-shaped equilibrium configuration. The potential energy barrier to the linear CCGe configuration was predicted to be 1218 cm -1 . The vibration-rotation energy levels of some GeC 2 isotopologues were calculated using a variational method. The vibrational bending mode ν 3 was found to be highly anharmonic, with the fundamental wavenumber being only 58 cm -1 . Vibrational progressions due to this mode were predicted for the v1=1, v2=1, and v2=2 states of GeC 2 . © 2018 Wiley Periodicals, Inc. © 2018 Wiley Periodicals, Inc.

  5. Rapid Detection of Polychlorinated Biphenyls at Trace Levels in Real Environmental Samples by Surface-Enhanced Raman Scattering

    Directory of Open Access Journals (Sweden)

    Zhengjun Zhang

    2011-11-01

    Full Text Available Detection of trace levels of persistent pollutants in the environment is difficult but significant. Organic pollutant homologues, due to their similar physical and chemical properties, are even more difficult to distinguish, especially in trace amounts. We report here a simple method to detect polychlorinated biphenyls (PCBs in soil and distilled spirit samples by the surface-enhanced Raman scattering technique using Ag nanorod arrays as substrates. By this method, polychlorinated biphenyls can be detected to a concentration of 5 μg/g in dry soil samples within 1 minute. Furthermore, based on simulation and understanding of the Raman characteristics of PCBs, we recognized homologues of tetrachlorobiphenyl by using the surface-enhance Raman scattering method even in trace amounts in acetone solutions, and their characteristic Raman peaks still can be distinguished at a concentration of 10-6 mol/L. This study provides a fast, simple and sensitive method for the detection and recognition of organic pollutants such as polychlorinated biphenyls.

  6. The concept of an ACEX(R) cost-effective first level surface detector trigger in the Pierre Auger Observatory

    International Nuclear Information System (INIS)

    Szadkowski, Z.

    2005-01-01

    The paper describes the new design of the first level trigger for the surface array in the Pierre Auger Observatory. The previous design was tested in a small test segment called Engineering Array (EA). It confirmed full functionality and reliability of the PLD approach. However, because of the high price of the chips available at that time, a new cost-effective design was developed. Altera ( R) offered cost-effective family, which allows reducing the total budget of the electronics without compromise in the functionality. The here described concept of a splitting of data processing into two sub-channels implemented into the parallel working chips, the chips synchronization and the automatization of internal processing management, together with the fully pipelined AHDL code became the framework for the further implementation in the environmental condition of the Argentinian pampa

  7. Design and operational considerations of United States commercial near-surface low-level radioactive waste disposal facilities

    International Nuclear Information System (INIS)

    Birk, S.M.

    1997-10-01

    In accordance with the Low-Level Radioactive Waste Policy Amendments Act of 1985, states are responsible for providing for disposal of commercially generated low-level radioactive waste (LLW) within their borders. LLW in the US is defined as all radioactive waste that is not classified as spent nuclear fuel, high-level radioactive waste, transuranic waste, or by-product material resulting from the extraction of uranium from ore. Commercial waste includes LLW generated by hospitals, universities, industry, pharmaceutical companies, and power utilities. LLW generated by the country''s defense operations is the responsibility of the Federal government and its agency, the Department of Energy. The commercial LLRW disposal sites discussed in this report are located near: Sheffield, Illinois (closed); Maxey Flats, Kentucky (closed); Beatty, Nevada (closed); West Valley, New York (closed); Barnwell, South Carolina (operating); Richland, Washington (operating); Ward Valley, California, (proposed); Sierra Blanca, Texas (proposed); Wake County, North Carolina (proposed); and Boyd County, Nebraska (proposed). While some comparisons between the sites described in this report are appropriate, this must be done with caution. In addition to differences in climate and geology between sites, LLW facilities in the past were not designed and operated to today''s standards. This report summarizes each site''s design and operational considerations for near-surface disposal of low-level radioactive waste. The report includes: a description of waste characteristics; design and operational features; post closure measures and plans; cost and duration of site characterization, construction, and operation; recent related R and D activities for LLW treatment and disposal; and the status of the LLW system in the US

  8. MERRA 2D IAU Ocean Surface Diagnostic, Single Level, Time Avg 1-hr (2/3x1/2L1) V5.2.0

    Data.gov (United States)

    National Aeronautics and Space Administration — The MAT1NXOCN or tavg1_2d_ocn_Nx data product is the MERRA Data Assimilation System 2-Dimensional ocean surface single-level diagnostics that is time averaged...

  9. GHRSST Level 2P 1 m Depth Global Sea Surface Temperature from the Visible Infrared Imaging Radiometer Suite (VIIRS) on the Suomi NPP satellite (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A global Group for High Resolution Sea Surface Temperature (GHRSST) Level 2P dataset based on retrievals from the Visible Infrared Imaging Radiometer Suite (VIIRS)....

  10. Variations in uranium and radioactivity levels in surface and ground water at selected sites in British Columbia, April 1980 - March 1981

    International Nuclear Information System (INIS)

    1981-07-01

    This report summarizes field and analytical work carried out between April, 1980 and March, 1981 on a program to investigate uranium and radioactivity levels in potable surface and ground water in selected regions throughout British Columbia

  11. MERRA 2D IAU Ocean Surface Diagnostic, Single Level, Monthly Mean (2/3x1/2L1) V5.2.0

    Data.gov (United States)

    National Aeronautics and Space Administration — The MATMNXOCN or tavgM_2d_ocn_Nx data product is the MERRA Data Assimilation System 2-Dimensional ocean surface single-level diagnostics that is monthly mean...

  12. MERRA 2D IAU Ocean Surface Diagnostic, Single Level, Diurnal (2/3x1/2L1) V5.2.0

    Data.gov (United States)

    National Aeronautics and Space Administration — The MATUNXOCN or tavgU_2d_ocn_Nx data product is the MERRA Data Assimilation System 2-Dimensional ocean surface single-level diagnostics that is monthly mean...

  13. GHRSST Level 3P Global Subskin Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the MetOp-A satellite (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A global Level 3 Group for HIgh Resolution Sea Surface Temperature (GHRSST) dataset from the Advanced Very High Resolution Radiometer (AVHRR) on the MetOp-A platform...

  14. GHRSST Level 3C North Atlantic Regional (NAR) subskin Sea Surface Temperature from SNPP/VIIRS (GDS V2) produced by OSI SAF (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A regional Group for High Resolution Sea Surface Temperature (GHRSST) Level 3 Collated (L3C) dataset for the North Atlantic Region (NAR) based on retrievals from the...

  15. Muscle-tendon units localization and activation level analysis based on high-density surface EMG array and NMF algorithm

    Science.gov (United States)

    Huang, Chengjun; Chen, Xiang; Cao, Shuai; Zhang, Xu

    2016-12-01

    Objective. Some skeletal muscles can be subdivided into smaller segments called muscle-tendon units (MTUs). The purpose of this paper is to propose a framework to locate the active region of the corresponding MTUs within a single skeletal muscle and to analyze the activation level varieties of different MTUs during a dynamic motion task. Approach. Biceps brachii and gastrocnemius were selected as targeted muscles and three dynamic motion tasks were designed and studied. Eight healthy male subjects participated in the data collection experiments, and 128-channel surface electromyographic (sEMG) signals were collected with a high-density sEMG electrode grid (a grid consists of 8 rows and 16 columns). Then the sEMG envelopes matrix was factorized into a matrix of weighting vectors and a matrix of time-varying coefficients by nonnegative matrix factorization algorithm. Main results. The experimental results demonstrated that the weightings vectors, which represent invariant pattern of muscle activity across all channels, could be used to estimate the location of MTUs and the time-varying coefficients could be used to depict the variation of MTUs activation level during dynamic motion task. Significance. The proposed method provides one way to analyze in-depth the functional state of MTUs during dynamic tasks and thus can be employed on multiple noteworthy sEMG-based applications such as muscle force estimation, muscle fatigue research and the control of myoelectric prostheses. This work was supported by the National Nature Science Foundation of China under Grant 61431017 and 61271138.

  16. Long-term ambient air pollution exposure and risk of high blood pressure among citizens in Nis, Serbia.

    Science.gov (United States)

    Stanković, Aleksandra; Nikolić, Maja

    2016-01-01

    Epidemiological studies suggest that long-term exposure to air pollution increases the risk for high blood pressure (BP). The aim of our study is to evaluate any effects in BP in citizens exposed to long-term ambient air pollution. The subjects are 1136 citizens, aged 18-70 years, living for more than 5 years in the same home in the areas with a different level of air pollution. The air concentrations of black smoke and sulfur dioxide were determined in the period from 2001 to 2011. We measured systolic and diastolic BP and heart rate. Multivariate methods were used in the analysis. Alcohol consumption had the greatest influence on the incidence of hypertension as a risk factor (RR: 3.461; 95% CI: 1.72-6.93) and age had the least (RR: 1.23; 95% CI: 1.183-1.92). Exposure to air pollution increases risk for developing hypertension 2.5 times (95% CI: 1.46-4.49). Physical activity has proved to be statistically significant protective factor for the development of hypertension. Long-term exposure to low levels of main air pollutants is significantly associated with elevated risk of hypertension.

  17. Structure-based sampling and self-correcting machine learning for accurate calculations of potential energy surfaces and vibrational levels

    Science.gov (United States)

    Dral, Pavlo O.; Owens, Alec; Yurchenko, Sergei N.; Thiel, Walter

    2017-06-01

    We present an efficient approach for generating highly accurate molecular potential energy surfaces (PESs) using self-correcting, kernel ridge regression (KRR) based machine learning (ML). We introduce structure-based sampling to automatically assign nuclear configurations from a pre-defined grid to the training and prediction sets, respectively. Accurate high-level ab initio energies are required only for the points in the training set, while the energies for the remaining points are provided by the ML model with negligible computational cost. The proposed sampling procedure is shown to be superior to random sampling and also eliminates the need for training several ML models. Self-correcting machine learning has been implemented such that each additional layer corrects errors from the previous layer. The performance of our approach is demonstrated in a case study on a published high-level ab initio PES of methyl chloride with 44 819 points. The ML model is trained on sets of different sizes and then used to predict the energies for tens of thousands of nuclear configurations within seconds. The resulting datasets are utilized in variational calculations of the vibrational energy levels of CH3Cl. By using both structure-based sampling and self-correction, the size of the training set can be kept small (e.g., 10% of the points) without any significant loss of accuracy. In ab initio rovibrational spectroscopy, it is thus possible to reduce the number of computationally costly electronic structure calculations through structure-based sampling and self-correcting KRR-based machine learning by up to 90%.

  18. Farmācijas doktors profesors Jānis Maizīte - viens no farmācijas muzeja veidotājiem

    Directory of Open Access Journals (Sweden)

    Inta Vegnere

    2010-12-01

    Full Text Available Pagājušajā gadā vienam no pirmās Latvijas brīvvalsts laika ievērojamākajiem farmaceitiem profesoram Jānim Maizītem apritēja 125 gadi. Profesors allaž atradies tālaika farmaceitu sabiedriskās dzīves centrā, līdzcilvēki viņu dēvējuši par Latvijas farmaceitu dvēseli. Jānis Maizīte dzimis 1883. gada 10. maijā Liepas pagasta Leču mājās kalēja ģimenē. Izglītību ieguvis Liepas pagastskolā, pēc tam mācījies privātā vidusskolā Valmierā. 1898. gadā kā eksterns nokārtojis eksāmenu Rīgas Nikolaja ģimnāzijā. Vēlēdamies iepazīties ar farmāciju, Jānis Maizīte no 1898. līdz 1901. gadam strādājis par aptiekāra mācekli Vjazmas aptiekā. 1901. gadā Tērbatas Universitātē kā eksterns nokārtojis aptiekāra palīga eksāmenu. Pēc tam līdz 1904. gadam strādājis dažādās Krievijas aptiekās (Strahovā, Astrahaņā. 1904. gadā J. Maizīte iestājies Tērbatas Universitātes Medicīnas fakultātes Farmācijas nodaļā, kuru beidzis 1908. gadā, iegūstot provizora specialitāti. Pēc tam turpat iecelts par jaunāko laborantu (asistentu, bet 1914. gadā – par vecāko asistentu. 1909. gadā. J. Maizīte nokārtojis mutiskus un rakstiskus eksāmenus farmācijas maģistra grāda iegūšanai un profesora I. Kondakova vadībā uzsācis darbu pie maģistra disertācijas "Par pinēna halogēnhidrātiem un to pārvēršanos ciklēna un santēna tipu ogļūdeņražos". Bet sākoties I Pasaules karam, Jāni Maizīti iesauca aktīvajā karadienestā par rezerves farmaceitu, tāpēc viņš šo darbu nepaguva aizstāvēt. Tikai 1924. gadā darbu par maģistra disertācijas tēmu viņš publicēja kopā ar savu skolotāju.

  19. Analysis of different smoke plume products to remove potential bias between satellite AOD and surface level PM2.5

    Science.gov (United States)

    Nazmi, Chowdhury

    Satellite remote sensing has the potential for direct observation of aerosols based on the property of atmospheric reflection of sunlight due to particulate scattering. Since particle mass to some level of approximation is linearly related to the optical scattering coefficient of the particles, this implies that the total column integrated aerosol optical depth (AOD) measurements would also be connected to surface PM2.5 through a simple linear model. Unfortunately, a wide range of factors can greatly modify the AOD to PM2.5 relationship including such factors as: 1. Planetary Boundary Layer Height (PBLH) 2. Aerosol type 3. Meteorology such as wind speed, RH, temperature etc. 4. Aloft Plume Contamination which affects the satellite AOD without changing the surface PM2.5. While existing approaches using ancillary meteorology and CTM's have been made in an effort to extract PM2.5, little consideration has been focused on the 4th factor which clearly has the potential to bias the result by overestimating the PBL AOD by adding the Aloft Aerosol contribution. Our results study a number of potential smoke plume indicators. In particular, we show that the multi-year GOES-ASDTA smoke product, the NAAPS aerosol model and to a lesser extent, the OMI Aerosol data products can be used to get a useful smoke indicator (averaged over an extended area) that can significantly eliminate smoke contaminated cases. This is illustrated by improved regression results for conditions when linear behavior is expected to dominate. In motivating this study, it should be pointed out that even though the filtering process can be inexact and result in a large amount of data being removed from the analysis, further improvements in satellite observation technology such as GOES-R (multi-time aggregation) and better methods to perform single pixel type retrievals using better surface modelling will result in a very large gain in satellite AOD retrievals making it less problematic for additional

  20. COPING WITH AND MANAGING STRESS STYLES OF FRESHMEN PHYSICAL EDUCATION STUDENTS AT THE PE FACULTY IN NIS

    Directory of Open Access Journals (Sweden)

    Danica Pirsl

    2005-05-01

    Full Text Available Stress is frequently viewed as an enemy. This is a misconception. Stress is often neither positive nor negative. Selye referred to stress judged as "good" as eustress. Distress, on the other hand, is stress that results in negative responses. Unchecked negative stress can interfere with the physiological and psychological functioning of the body and may ultimately result in disease or disability. A stressor is any physical, psychological or environmental event, or condition that initiates the stress. The body responds with the same threestage process. This series of changes is known as the general adaptation syndrome (GAS. The three phases are alarm, resistance, and exhaustion. It is interesting to note that PE students form their own stress copying styles in the mental, emotional and physical areas. Results are enhanced activities, sense of control and high energy level. Both male and female students show similar patterns of behaviour in stressful situations but female students show more interest in sporting activities when in stress-related situation

  1. Preoperative shower revisited: can high topical antiseptic levels be achieved on the skin surface before surgical admission?

    Science.gov (United States)

    Edmiston, Charles E; Krepel, Candace J; Seabrook, Gary R; Lewis, Brian D; Brown, Kellie R; Towne, Jonathan B

    2008-08-01

    Skin asepsis is a sentinel strategy for reducing risk of surgical site infections. In this study, chlorhexidine gluconate (CHG) skin concentrations were determined after preoperative showering/skin cleansing using 4% CHG soap or 2% CHG-impregnated polyester cloth. Subjects were randomized to one of three shower (4% soap)/skin cleansing (2% cloth) groups (n = 20 per group): (group 1 A/B) evening, (group 2 A/B) morning, or (group 3 A/B) evening and morning. After showering or skin cleansing, volunteers returned to the investigator's laboratory where CHG skin surface concentrations were determined at five separate skin sites. CHG concentrations were compared with CHG minimal inhibitory concentration that inhibits 90% (MIC(90)) of staphylococcal skin isolates. CHG MIC(90) for 61 skin isolates was 4.8 parts per million (ppm). In group 1A, 4% CHG skin concentrations ranged from 17.2 to 31.6 ppm, and CHG concentrations were 361.5 to 589.5 ppm (p < 0.0001) in group 1B (2%). In group 2A (4%), CHG levels ranged from 51.6 to 119.6 ppm and 848.1 to 1,049.6 ppm in group 2B (2%), respectively (p < 0.0001). CHG levels ranged from 101.4 to 149.4 ppm in the 4% CHG group (group 3A) compared with 1,484.6 to 2,031.3 ppm in 2% CHG cloth (group 3B) group (p < 0.0001). Effective CHG levels were not detected in the 4% CHG group in selected sites in seven (35%) subjects in group 1A, three (15%) in group 2A, and five (25%) in group 3A. Effective CHG levels were achieved on most skin sites after using 4% CHG; gaps in antiseptic coverage were noted at selective sites even after repeated application. Use of the 2% CHG polyester cloth resulted in considerably higher skin concentrations with no gaps in antiseptic coverage. Effective decolonization of the skin before hospital admission can play an important role in reducing risk of surgical site infections.

  2. Surface radiological investigations of Trench 6 and low-level waste Line Leak Site 7. 4b at the Oak Ridge National Laboratory, Oak Ridge, Tennessee

    Energy Technology Data Exchange (ETDEWEB)

    Uziel, M.S.; Tiner, P.F.; Williams, J.K.

    1991-08-01

    A surface radiological investigation of Trench 6 and low-level radioactive waste (LLW) Line Leak Site 7.4b was conducted in July and August 1989 and January 1990 by the Measurement Applications and Development Group, Oak Ridge National Laboratory. The purposes of this survey were (1) to determine the presence, nature, and extent of surface radiological contamination and (2) to recommend interim corrective action to limit human exposures to radioactivity and minimize the potential for contaminant dispersion. Highest surface gamma levels encountered during the survey (39 mR/h) were found just south of the asphalt covering LLW Line Leak Site 7.4b. Elevated surface gamma levels (measuring 28 to 560 {mu}R/h) extended from this area to a width of 100 ft, westward 250 ft, and beyond the survey boundary. Beta-gamma levels up to 17 mrad/h measured on contact with the trunks of trees growing in the area southwest of Trench 6 suggest that three roots are reaching contamination deep within the ground. Since no gamma activity is associated with the trees or their leaves, the elevated beta levels are probably due to the uptake of residual {sup 90}Sr originating from the documented seepage at the Trench 6/Leak Site 7.4b area. Beta activity present in the leaf litter and surface soil indicate that decaying leaves are depositing measurable contaminants on the ground surface. Recommendations for corrective actions are included. 7 refs., 20 figs., 3 tabs.

  3. Surface water characteristics and trace metals level of the Bonny/New Calabar River Estuary, Niger Delta, Nigeria

    Science.gov (United States)

    Onojake, M. C.; Sikoki, F. D.; Omokheyeke, O.; Akpiri, R. U.

    2017-05-01

    Surface water samples from three stations in the Bonny/New Calabar River Estuary were analyzed for the physicochemical characteristics and trace metal level in 2011 and 2012, respectively. Results show pH ranged from 7.56 to 7.88 mg/L; conductivity, 33,489.00 to 33,592.00 µScm-1; salinity, 15.33 to 15.50 ‰; turbidity, 4.35 to 6.65 NTU; total dissolved solids, 22111.00 to 23263.00 gm-3; dissolved oxygen, 4.53 to 6.65 mg/L; and biochemical oxygen demand, 1.72 mg/L. The level of some trace metals (Ca, Mg, K, Zn, Pb, Cd, Co, Cr, Cu, Fe, Ni, and Na) were also analyzed by Atomic absorption spectrometry with K, Zn, and Co being statistically significant ( P < 0.05). The results were compared with USEPA and WHO Permissible Limits for water quality standards. It was observed that the water quality parameters in the Bonny Estuary show seasonal variation with higher values for pH, DO, BOD, temperature, and salinity during the dry season than wet season. Concentrations of trace metals such as Pb, Cd, Zn, Ni, and Cr were higher than stipulated limits by WHO (2006). The result of the Metal Pollution Index suggests that the river was slightly affected and therefore continuous monitoring is necessary to avert possible public health implications of these metals on consumers of water and seafood from the study area.

  4. The role of the meridional sea surface temperature gradient in controlling the Caribbean low-level jet

    Science.gov (United States)

    Maldonado, Tito; Rutgersson, Anna; Caballero, Rodrigo; Pausata, Francesco S. R.; Alfaro, Eric; Amador, Jorge

    2017-06-01

    The Caribbean low-level jet (CLLJ) is an important modulator of regional climate, especially precipitation, in the Caribbean and Central America. Previous work has inferred, due to their semiannual cycle, an association between CLLJ strength and meridional sea surface temperature (SST) gradients in the Caribbean Sea, suggesting that the SST gradients may control the intensity and vertical shear of the CLLJ. In addition, both the horizontal and vertical structure of the jet have been related to topographic effects via interaction with the mountains in Northern South America (NSA), including funneling effects and changes in the meridional geopotential gradient. Here we test these hypotheses, using an atmospheric general circulation model to perform a set of sensitivity experiments to examine the impact of both SST gradients and topography on the CLLJ. In one sensitivity experiment, we remove the meridional SST gradient over the Caribbean Sea and in the other, we flatten the mountains over NSA. Our results show that the SST gradient and topography have little or no impact on the jet intensity, vertical, and horizontal wind shears, contrary to previous works. However, our findings do not discount a possible one-way coupling between the SST and the wind over the Caribbean Sea through friction force. We also examined an alternative approach based on barotropic instability to understand the CLLJ intensity, vertical, and horizontal wind shears. Our results show that the current hypothesis about the CLLJ must be reviewed in order to fully understand the atmospheric dynamics governing the Caribbean region.

  5. Use of the discriminant Fourier-derived cepstrum with feature-level post-processing for surface electromyographic signal classification

    International Nuclear Information System (INIS)

    Chen, Xinpu; Zhu, Xiangyang; Zhang, Dingguo

    2009-01-01

    Myoelectrical pattern classification is a crucial part in multi-functional prosthesis control. This paper investigates a discriminant Fourier-derived cepstrum (DFC) and feature-level post-processing (FLPP) to discriminate hand and wrist motions using the surface electromyographic signal. The Fourier-derived cepstrum takes advantage of the Fourier magnitude or sub-band power energy of signals directly and provides flexible use of spectral information changing with different motions. Appropriate cepstral coefficients are selected by a proposed separability criterion to construct DFC features. For the post-processing, FLPP which combines features from several analysis windows is used to improve the feature performance further. In this work, two classifiers (a linear discriminant classifier and quadratic discriminant classifier) without hyper-parameter optimization are employed to simplify the training procedure and avoid the possible bias of feature evaluation. Experimental results of the 11-motion problem show that the proposed DFC feature outperforms traditional features such as time-domain statistics and autoregressive-derived cepstrum in terms of the classification accuracy, and it is a promising method for the multi-functionality and high-accuracy control of myoelectric prostheses

  6. C-Band Airport Surface Communications System Engineering-Initial High-Level Safety Risk Assessment and Mitigation

    Science.gov (United States)

    Zelkin, Natalie; Henriksen, Stephen

    2011-01-01

    This document is being provided as part of ITT's NASA Glenn Research Center Aerospace Communication Systems Technical Support (ACSTS) contract: "New ATM Requirements--Future Communications, C-Band and L-Band Communications Standard Development." ITT has completed a safety hazard analysis providing a preliminary safety assessment for the proposed C-band (5091- to 5150-MHz) airport surface communication system. The assessment was performed following the guidelines outlined in the Federal Aviation Administration Safety Risk Management Guidance for System Acquisitions document. The safety analysis did not identify any hazards with an unacceptable risk, though a number of hazards with a medium risk were documented. This effort represents an initial high-level safety hazard analysis and notes the triggers for risk reassessment. A detailed safety hazards analysis is recommended as a follow-on activity to assess particular components of the C-band communication system after the profile is finalized and system rollout timing is determined. A security risk assessment has been performed by NASA as a parallel activity. While safety analysis is concerned with a prevention of accidental errors and failures, the security threat analysis focuses on deliberate attacks. Both processes identify the events that affect operation of the system; and from a safety perspective the security threats may present safety risks.

  7. The role of surface and deep-level defects on the emission of tin oxide quantum dots

    International Nuclear Information System (INIS)

    Kumar, Vinod; Kumar, Vijay; Som, S; Ntwaeaborwa, O M; Swart, H C; Neethling, J H; Lee, Mike

    2014-01-01

    This paper reports on the role of surface and deep-level defects on the blue emission of tin oxide quantum dots (SnO 2 QDs) synthesized by the solution-combustion method at different combustion temperatures. X-ray diffraction studies showed the formation of a single rutile SnO 2 phase with a tetragonal lattice structure. High resolution transmission electron microscopy studies revealed an increase in the average dot size from 2.2 to 3.6 nm with an increase of the combustion temperature from 350 to 550 °C. A decrease in the band gap value from 3.37 to 2.76 eV was observed with the increase in dot size due to the quantum confinement effect. The photoluminescence emission was measured for excitation at 325 nm and it showed a broad blue emission band for all the combustion temperatures studied. This was due to the creation of various oxygen and tin vacancies/defects as confirmed by x-ray photoelectron spectroscopy data. The origin of the blue emission in the SnO 2 QDs is discussed with the help of an energy band diagram. (paper)

  8. Sea level rise, surface warming, and the weakened buffering ability of South China Sea to strong typhoons in recent decades.

    Science.gov (United States)

    Sun, Jingru; Oey, Leo; Xu, F-H; Lin, Y-C

    2017-08-07

    Each year, a number of typhoons in the western North Pacific pass through the Luzon Strait into South China Sea (SCS). Although the storms remain above a warm open sea, the majority of them weaken due to atmospheric and oceanic environments unfavorable for typhoon intensification in SCS, which therefore serves as a natural buffer that shields the surrounding coasts from potentially more powerful storms. This study examines how this buffer has changed over inter-decadal and longer time scales. We show that the buffer weakens (i.e. greater potential for more powerful typhoons) in negative Pacific Decadal Oscillation (PDO) years, as well as with sea-level-rise and surface warming, caused primarily by the deepening of the ocean's 26 °C isotherm Z 26 . A new Intensity Change Index is proposed to describe the typhoon intensity change as a function of Z 26 and other environmental variables. In SCS, the new index accounts for as high as 75% of the total variance of typhoon intensity change.

  9. Concentration Levels and Ecological Risks of Persistent Organic Pollutants in the Surface Sediments of Tianjin Coastal Area, China

    Directory of Open Access Journals (Sweden)

    Xiaoxia Lu

    2013-01-01

    Full Text Available Sediments were sampled from different surface water bodies in Tianjin coastal area, China, and persistent organic pollutants (POPs including polycyclic aromatic hydrocarbons (PAHs, organochlorine pesticides (OCPs, polychlorinated biphenyls (PCBs, and polybrominated diphenyl ethers (PBDEs were measured using GC/MS or GC/ECD. The purposes were to investigate the concentration levels of the POPs and to assess their ecological risks. The results showed that all the 16 priority PAHs were detected from the 10 sediments sampled with the total concentrations of the 16 PAHs ranging from 274.06 μg/kg to 2656.65 μg/kg, while the concentrations of the halogenated POPs were generally low except in the Dagu waste discharging river where the total concentrations of 24 OCPs, 35 PCBs, and 14 PBDEs were 3103.36 μg/kg, 87.31 μg/kg, and 13.88 μg/kg, respectively. In the studied sediments, PAHs exhibited risks to benthonic organisms; particularly the concentrations of naphthalene and/or acenaphthene exceeded their probable effect concentrations in several locations. In comparison, only in the Dagu waste discharging river, OCPs exhibited risks with the concentrations of heptachlor epoxide and lindane exceeding their probable effect concentrations. PCBs and PBDEs posed rare risks in the studied area.

  10. BAERLIN2014 – the influence of land surface types on and the horizontal heterogeneity of air pollutant levels in Berlin

    Directory of Open Access Journals (Sweden)

    B. Bonn

    2016-06-01

    -wise measurement of volatile organic compounds (VOCs at representative sites for traffic- and vegetation-affected sites. The quantification displayed notable horizontal heterogeneity of the short-lived gases and particle number concentrations. For example, baseline concentrations of the traffic-related chemical species CO and NO varied on average by up to ±22.2 and ±63.5 %, respectively, on the scale of 100 m around any measurement location. Airborne observations revealed the dominant source of elevated urban particulate number and mass concentrations being local, i.e., not being caused by long-range transport. Surface-based observations related these two parameters predominantly to traffic sources. Vegetated areas lowered the pollutant concentrations substantially with ozone being reduced most by coniferous forests, which is most likely caused by their reactive biogenic VOC emissions. With respect to the overall potential to reduce air pollutant levels, forests were found to result in the largest decrease, followed by parks and facilities for sports and leisure. Surface temperature was generally 0.6–2.1 °C lower in vegetated regions, which in turn will have an impact on tropospheric chemical processes. Based on our findings, effective future mitigation activities to provide a more sustainable and healthier urban environment should focus predominantly on reducing fossil-fuel emissions from traffic as well as on increasing vegetated areas.

  11. Effects of surface chromium depletion on localized corrosion of alloy 825 as a high-level nuclear waste container material

    International Nuclear Information System (INIS)

    Dunn, D.S.; Sridhar, N.; Cragnolino, G.A.

    1995-01-01

    Effects of the chromium-depleted, mill-finished surface on the localized corrosion resistance of alloy 825 (UNS N08825) were investigated. Tests were conducted in solutions based on the ground water at Yucca mountain, Nevada, but with a higher concentration of chloride. Results indicated that breakdown (E p ) and repassivation (E rp ) potentials for mill-finished surfaces were more active than those for polished surfaces. Potentiodynamic polarization tests indicated pits could be initiated on the chromium-depleted surface at potentials of 220 mV SCE in a solution containing 1,000 ppm Cl - at 95 C. Potentiostatic tests identified a similar pit initiation potential for the mill-finished surface. However, under longterm potentiostatic tests, a higher potential of 300 mV SCE was needed to sustain stable pit growth beyond the chromium-depleted layer. An increase in surface roughness also was observed to decrease localized corrosion resistance of the material

  12. Rendering of surface-geometries at job-generation level for camouflaging the layered nature of Additively Manufactured parts

    DEFF Research Database (Denmark)

    Pedersen, D. B.; Hansen, H. N.; Nielsen, J. S.

    2014-01-01

    ] It is proposed to camouflage these layers in order to produce parts with a better visual appeal, and to add functional surface structures. In order to generate such surface structures without adding a challenging computational overhead at job-generation, inspiration from Computer Generated Imaging (CGI) is found...

  13. AVHRR Pathfinder version 5.3 level 3 collated (L3C) global 4km sea surface temperature

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The AVHRR Pathfinder Version 5.3 (PFV53) L3C Sea Surface Temperature data set is a collection of global, twice-daily (Day and Night) 4km sea surface temperature...

  14. History of surface displacements at the Yellowstone Caldera, Wyoming, from leveling surveys and InSAR observations, 1923-2008

    Science.gov (United States)

    Dzurisin, Daniel; Wicks, Charles W.; Poland, Michael P.

    2012-01-01

    during June-July 1995 - the strongest swarm since 1985. Rather than a single deformation source as inferred from leveling surveys, the InSAR images revealed two distinct sources - one beneath each resurgent dome on the caldera floor. Subsequently, repeated GPS surveys (sometimes referred to as "campaign" surveys to distinguish them from continuous GPS observations) and InSAR images revealed a third deformation source beneath the north caldera rim. The north-rim source started to inflate in or about 1995, resulting in as much as 80 mm of surface uplift by 2000. Meanwhile, motion of the caldera floor changed from uplift to subsidence during 1997-8. The north rim area rose, while the entire caldera floor (including both domes) subsided until 2002, when both motions paused. Uplift in the northeast part of the caldera resumed in mid-2004 at a historically unprecedented rate of as much as 70 mm/yr, while the north rim area subsided at a lesser rate. Resurveys of the level line across the northeast part of the caldera in 2005 and 2007 indicated the greatest average uplift rate since the initial survey in 1923-53±3 mm/yr. Data from a nearby continuous GPS (CGPS) station showed that the uplift rate slowed to 40-50 mm/yr during 2007-8 and to near zero by September 2009. Following an intense earthquake swarm during January-February 2010, this one near the northwest caldera rim and the strongest since the 1985 swarm in the same general area, CGPS stations recorded the onset of subsidence throughout the entire caldera. Any viable model for the cause(s) of ground deformation at Yellowstone should account for (1) three distinct deformation sources and their association with both resurgent domes and the north caldera rim; (2) interplay among these sources, as suggested by the timing of major changes in deformation mode; (3) migration of the area of greatest subsidence or uplift from the northeast part of the caldera to the southwest part during 1992-95 and 1995-97, respectively; (4

  15. The impact of surface currents and sea level on the wave field evolution during St. Jude storm in the eastern Baltic Sea

    Directory of Open Access Journals (Sweden)

    Marili Viitak

    2016-07-01

    Full Text Available A third generation numerical wave model SWAN (Simulating WAves Nearshore was applied to study the spatio-temporal effect of surface currents and sea level height on significant wave height; and to describe the mechanisms responsible for wave–current interaction in the eastern Baltic Sea. Simulation results were validated by comparison with in situ wave measurements in deep and shallow water, carried out using the directional wave buoy and RDCP respectively, and with TerraSAR-X imagery. A hindcast period from 23 to 31 October 2013 included both a period of calm to moderate weather conditions and a severe North-European windstorm called St. Jude. The prevailing wind directions were southerly to westerly. Four simulations with SWAN were made: a control run with dynamical forcing by wind only; and simulations with additional inputs of surface currents and sea level, both separately and combined. A clear effect of surface currents and sea level on the wave field evolution was found. It manifested itself as an increase or decrease of significant wave height of up to 20%. The strength of the interaction was influenced by the propagation directions of waves and surface currents and the severity of weather conditions. An increase in the wave height was mostly seen in shallower waters and in areas where waves and surface currents were propagating in opposite directions. In deeper parts of the eastern Baltic Sea and in case of waves and surface currents propagating in the same direction a decrease occurred.

  16. Towards an atomic level understanding of niobia based catalysts and catalysis by combining the science of catalysis with surface science

    Directory of Open Access Journals (Sweden)

    Martin Schmal

    2009-06-01

    Full Text Available The science of catalysis and surface science have developed, independently, key information for understanding catalytic processes. One might argue: is there anything fundamental to be discovered through the interplay between catalysis and surface science? Real catalysts of monometallic and bimetallic Co/Nb2O5 and Pd-Co/Nb2O5 catalysts showed interesting selectivity results on the Fischer-Tropsch synthesis (Noronha et al. 1996, Rosenir et al. 1993. The presence of a noble metal increased the C+5 selectivity and decreased the methane formation depending of the reduction temperature. Model catalyst of Co-Pd supported on niobia and alumina were prepared and characterized at the atomic level, thus forming the basis for a comparison with "real" support materials. Growth, morphology and structure of both pure metal and alloy particles were studied. It is possible to support the strong metal support interaction suggested by studies on real catalysts via the investigation of model systems for niobia in comparison to alumina support in which this effect does not occur. Formation of Co2+ penetration into the niobia lattice was suggested on the basis of powder studies and can be fully supported on the basis of model studies. It is shown for both real catalysts and model systems that oxidation state of Co plays a key role in controlling the reactivity in Fischer-Tropsch reactions systems and that the addition of Pd is a determining factor for the stability of the catalyst. It is demonstrated that the interaction with unsaturated hydrocarbons depends strongly on the state of oxidation.As ciências da catálise e da superfície têm desenvolvido independentemente temas básicos para o entendimento de processos catalíticos. Pode-se até questionar se há ainda algo fundamental para ser descoberto através da interface entre catálise eciência da superfície? Catalisadores mono e bimetálicos de Co/Nb2O5 e Pd-Co/ Nb2O5 apresentaram resultados interessantes de

  17. Arctic Radiation Measurement in Column: Atmosphere-Surface (ARMCAS) MODIS Airborne Simulator (MAS) Level-1B Data Products

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of the Arctic Radiation Measurement in Column: Atmosphere-Surface (ARMCAS) experiment was to detect and differentiate between clouds, ice, and snow...

  18. NUMERICAL DESCRIPTION OF THE GROUNDWATER LEVELS CHANGE DUE TO THE RE- AND DISCHARGE OF THE ADJACENT SURFACE WATER BODIES – PROBLEMS AND CASE STUDIES

    Directory of Open Access Journals (Sweden)

    G. Trendafilov

    2012-03-01

    Full Text Available Numerical description of the groundwater levels change due to the re- and discharge of the adjacent surface water bodies – problems and case studies. The water exchange between the surface water bodies (rivers, lakes, seas, dams, etc. and adjacent water-bearing beds is possible if a hydraulic connection between them exists. The change of the levels of the first ones causes corresponding changes of the levels of the aquifers in the surrounding territories and vice versa. In many cases this interaction is the primary mechanism determining the groundwater regime. The aim of the present study is to examine the applicability of the most general possible analytical approach for quantitative description of the phenomena in the case of short-term changes with a significant magnitude (high waves of the level of the river of Maritsa in Plovdiv, Bulgaria. The study is performed through numerical simulations/calculations, with especially composed by the authors for this work computational programs.

  19. Brief communication "Global glacier volumes and sea level – small but systematic effects of ice below the surface of the ocean and of new local lakes on land"

    Directory of Open Access Journals (Sweden)

    W. Haeberli

    2013-05-01

    Full Text Available The potential contribution of glaciers and ice caps to sea level rise is usually calculated by comparing the estimated total ice volume with the surface area of the ocean. Part of this total ice volume, however, does not contribute to sea level rise because it is below the surface of the ocean or below the levels of future lakes on land. The present communication points to this so far overlooked phenomenon and provides a first order-of-magnitude estimate. It is shown that the effect is small (most likely about 1 to 6 cm sea level equivalent but systematic, could primarily affect earlier stages of global glacier vanishing, and should therefore be adequately considered. Now-available techniques of slope-related high-resolution glacier bed modelling have the potential to provide more detailed assessments in the future.

  20. Structural origin of Si-2p core-level shifts from Si(100)-c[4x2] surface: A spectral x-ray photoelectron diffraction study

    Energy Technology Data Exchange (ETDEWEB)

    Chen, X.; Tonner, B.P. [Univ. of Wisconsin, Milwaukee, WI (United States); Denlinger, J. [Univ. of Wisconsin, Milwaukee, WI (United States)][Ernest Orlando Lawrence Berkeley National Lab., CA (United States)] [and others

    1997-04-01

    The authors have performed angle-resolved x-ray photoelectron diffraction (XPD) from a Si(100)-c(4x2) surface to study the structural origin of Si-2p core-level shifts. In the experiment, the highly resolved surface Si-2p core-level spectra were measured as a fine grid of hemisphere and photon energies, using the SpectroMicroscopy Facility {open_quotes}ultraESCA{close_quotes} instrument. By carefully decomposing the spectra into several surface peaks, the authors are able to obtain surface-atom resolved XPD patterns. Using a multiple scattering analysis, they derived a detailed atomic model for the Si(100)-c(4x2) surface. In this model, the asymmetric dimers were found tilted by 11.5 plus/minus 2.0 degrees with bond length of 2.32 plus/minus 0.05{angstrom}. By matching model XPD patterns to experiment, the authors can identify which atoms in the reconstructed surface are responsible for specific photoemission lines in the 2p spectrum.

  1. Investigation of the extent of surface coating via mechanofusion with varying additive levels and the influences on bulk powder flow properties.

    Science.gov (United States)

    Zhou, Qi Tony; Qu, Li; Gengenbach, Thomas; Denman, John A; Larson, Ian; Stewart, Peter J; Morton, David A V

    2011-07-15

    The objective of this study was to investigate if the coating extent created by a mechanofusion process corresponded with observed changes in bulk powder properties. A fine lactose powder (approximate median diameter 20 μm) was dry coated with magnesium stearate using from 0.1 to 5% (w/w) content. An ultra-thin coating layer of magnesium stearate was anticipated, but previous attempts to determine such thin layers on these fine particles have had limited success, with poor resolution. In this study, the surface coating was examined using the state-of-the-art XPS and ToF-SIMS systems. The powder flow was characterized by Carr index and shear cell testing. XPS was successfully applied to demonstrate variations in surface coverage, as a function of additive levels, and indicated near complete coating coverage at additive levels of 1% (w/w) and above. ToF-SIMS results supported such coating coverage assessment, and indicated coating uniformly across the fine particle surfaces. The flow metrics employed could then be related to the coating coverage metrics. The mechanofusion process also modified the apparent surface roughness observed by SEM and BET. It was suggested that the changes in the surface chemical composition exerted a more evident and direct impact on the powder cohesion and flow characteristics than the changes in the surface morphological properties after the mechanofusion in this study. Copyright © 2011 Elsevier B.V. All rights reserved.

  2. CESARR V.2 manual: Computer code for the evaluation of surface storage of low and medium level radioactive waste

    International Nuclear Information System (INIS)

    Moya Rivera, J.A.; Bolado Lavin, R.

    1997-01-01

    CESARR (Code for the safety evaluation of low and medium level radioactive waste storage). This code was developed for the safety probabilistic evaluations in the facilities of low-and medium level radioactive waste storage

  3. The Effect of Using the Lakatosian Heuristic Method to Teach the Surface Area of a Cone on Students' Achievement According to Bloom's Taxonomy Levels

    Science.gov (United States)

    Dimitriou-Hadjichristou, Chrysoula; Ogbonnaya, Ugorji I.

    2015-01-01

    This paper reports a study on the effect of using the Lakatosian heuristic method to teach the surface area of a cone (SAC) on students' achievement according to Bloom's taxonomy levels. Two groups of students (experimental and control) participated in the study. The experimental group (n = 20) was taught using the Lakatosian heuristic method…

  4. Raising surface water levels in peat areas with dairy farming upscaling hydrological, agronomical and economic effects from farm-scale to local scale.

    NARCIS (Netherlands)

    Vos, de J.A.; Bakel, van P.J.T.; Hoving, I.E.; Smidt, R.A.

    2010-01-01

    Raising surface water levels in peat areas is a measure to reduce soil subsidence, to prevent decay of wooden foundations and to stimulate wet nature restoration and reduce greenhouse gas emissions. However, in these areas dairy farms are present and farming at wetter soils is difficult due to lower

  5. Estimating the Greenland ice sheet surface mass balance contribution to future sea level rise using the regional atmospheric climate model MAR

    NARCIS (Netherlands)

    Fettweis, X.; Franco, B.; Tedesco, M.; van Angelen, J.H.|info:eu-repo/dai/nl/325922470; Lenaerts, J.T.M.|info:eu-repo/dai/nl/314850163; van den Broeke, M.R.|info:eu-repo/dai/nl/073765643; Gallée, H.

    2013-01-01

    To estimate the sea level rise (SLR) originating from changes in surface mass balance (SMB) of the Greenland ice sheet (GrIS), we present 21st century climate projections obtained with the regional climate model MAR (Mod`ele Atmosph´erique R´egional), forced by output of three CMIP5 (Coupled Model

  6. Water levels and groundwater and surface-water exchanges in lakes of the northeast Twin Cities Metropolitan Area, Minnesota, 2002 through 2015

    Science.gov (United States)

    Jones, Perry M.; Trost, Jared J.; Erickson, Melinda L.

    2016-10-19

    OverviewThis study assessed lake-water levels and regional and local groundwater and surface-water exchanges near northeast Twin Cities Metropolitan Area lakes applying three approaches: statistical analysis, field study, and groundwater-flow modeling.  Statistical analyses of lake levels were completed to assess the effect of physical setting and climate on lake-level fluctuations of selected lakes. A field study of groundwater and surface-water interactions in selected lakes was completed to (1) estimate potential percentages of surface-water contributions to well water across the northeast Twin Cities Metropolitan Area, (2) estimate general ages for waters extracted from the wells, and (3) assess groundwater inflow to lakes and lake-water outflow to aquifers downgradient from White Bear Lake.  Groundwater flow was simulated using a steady-state, groundwater-flow model to assess regional groundwater and surface-water exchanges and the effects of groundwater withdrawals, climate, and other factors on water levels of northeast Twin Cities Metropolitan Area lakes.

  7. Long-term effects of surface coal mining on ground-water levels and quality in two small watersheds in eastern Ohio

    International Nuclear Information System (INIS)

    Cunningham, W.L.; Jones, R.L.

    1990-01-01

    Two small eastern Ohio watersheds surface mined for coal and reclaimed were studied during 1986-89. Water level and water quality data were compared with data from investigations conducted during 1976-83 to determine long-term effects of surface mining on the hydrologic system. Before mining, the watersheds were characterized by flatlying sedimentary rocks above clay beds underlying two major coal seams. Two aquifers overlay each under clay. Surface mining removed the upper aquifer, stripped the coal seam, and replaced the spoil, creating a new aquifer with hydraulic and chemical characteristics different from those of the original upper aquifer. Water levels were measured continuously in one well in each aquifer and every 2 months in other wells. Water levels in upper aquifers reached hydraulic equilibrium from 2 to 5 years after mining and, in middle aquifers, water levels increased more than 5 ft during mining; equilibrium occurred almost immediately thereafter. Water samples were collected from three upper aquifer wells, one middle-aquifer well, a seep from the upper aquifer, and the stream in each watershed. Samples were collected in 1986, 1987, 1988, and 1989. In both watersheds, sulfate replaced bicarbonate as the dominant anion in the upper aquifer after mining. In general, significant increases in concentrations of dissolved constituents in groundwater resulted from surface mining. The continued decrease in pH indicates that groundwater had not reached complete geochemical equilibrium in either watershed more than 8 years after mining ended

  8. Surface disposal of low-level and medium-level short-lived waste. How safe is the disposal facility in Dessel in the long term?

    International Nuclear Information System (INIS)

    2014-01-01

    A disposal facility for the disposal of low-level and medium-level short-lived waste is planned to be built on a site located in the community of Dessel (Belgium). The facility will consist of 34 modules, corresponding to a storage volume capacity of approximately 70,000 m3. The disposal concept includes waste containers that are encapsulated in a concrete box which is filled with mortar. Approximately 900 of these blocks, or monoliths, fit inside each module. The article discusses the Research and Development programme that has been conducted at the Belgian Nuclear Research Center SCK-CEN in conjunction with the development of this facility. Main emphasis is on the models that have been developed for predicting the long-term containment of the disposal facility.

  9. The use of image analysis for determination of surface deterioration level of improved alumina based materials subjected to cavitation

    Directory of Open Access Journals (Sweden)

    Dimitrijević M.M.

    2013-01-01

    Full Text Available Alumina based specimens having different content of alumina based fibers were investigated for possible application as cavitation resistant material. Cavitation damages of the alumina based specimens were tested by the modified vibratory cavitation set up. Erosion rates were measured based on the method developed for metallic samples, mass loss was measured during the experiment. Surface erosion was determined during the experiment simultaneously to mass loss measurements. Image Pro Plus Program was applied for surface analysis during testing. Results indicate that investigated material exhibit excellent mechanical properties and very good resistance to cavitation erosion. [Projekat Ministarstva nauke Republike Srbije, br. TR34011, br. TR35002 i br. III 45012

  10. Effect of Reynolds number and saturation level on gas diffusion in and out of a superhydrophobic surface

    Science.gov (United States)

    Ling, Hangjian; Katz, Joseph; Fu, Matthew; Hultmark, Marcus

    2017-12-01

    This experimental study investigates the effects of ambient pressure and Reynolds number on the volume of a plastron in a superhydrophobic surface (SHS) due to compression and gas diffusion. The hierarchical SHS consists of nanotextured, ˜100 μm wide spanwise grooves. Microscopic observations measure the time evolution of interface height and contact angle. The water tunnel tests are performed both without flow as well as in transitional and turbulent boundary layers at several Reynolds numbers. Particle image velocimetry is used for estimating the wall shear stress and calculating the momentum thickness for the SHSs under Cassie-Baxter (CB) and Wenzel states as well as a smooth wall at the same conditions. Holographic microscopy is used for determining the wall shear stress directly for one of the CB cases. The mass diffusion rate is calculated from changes to the plastron volume when the liquid is under- or supersaturated. For stationary water, the mass diffusion is slow. With increasing pressure, the interface is initially pinned and then migrates into the groove with high advancing contact angle. Upon subsequent decrease in pressure, the interface migrates upward at a shallow angle and, after being pinned to the tip corner, becomes convex. With flow and exposure to undersaturated liquid, the diffusion-induced wetting also involves pinned and downward migration states, followed by shrinkage of the plastron until it decreases below the resolution limit. The corresponding changes to the velocity profile indicate a transition from slight drag reduction to significant drag increase. In supersaturated water starting at a Wenzel state, a bubble grows from one of the bottom corners until it reaches the other side of the groove. Subsequently, dewetting involves upward migration of the interface, pinning to the tip corners, and formation of a convex interface. The diffusion rate increases with the level of under- or supersaturation and with the Reynolds number. A power

  11. Achieving Very Low Levels of Detection: An Improved Surface-Enhanced Raman Scattering Experiment for the Physical Chemistry Teaching Laboratory

    Science.gov (United States)

    McMillan, Brian G.

    2016-01-01

    This experiment was designed and successfully introduced to complement the nanochemistry taught to undergraduate students in a useful and interesting way. Colloidal Ag nanoparticles were synthesized by a simple, room-temperature method, and the resulting suspension was then used to study the surface-enhanced Raman scattering (SERS) of methylene…

  12. Estimating Greenland ice sheet surface mass balance contribution to future sea level rise using the regional atmospheric climate model MAR

    NARCIS (Netherlands)

    Fettweis, X.; Franco, B.; Tedesco, M.; van Angelen, J.H.; Lenaerts, J.T.M.; van den Broeke, M.R.; Gallee, H

    2012-01-01

    We report future projections of Surface Mass Balance (SMB) over the Greenland ice sheet (GrIS) obtained with the regional climate model MAR, forced by the outputs of three CMIP5 General Circulation Models (GCMs) when considering two different warming scenarios (RCP 4.5 and RCP 8.5). The GCMs

  13. Rendering of surface-geometries at job-generation level for camouflaging the layered nature of Additively Manufactured parts

    DEFF Research Database (Denmark)

    Pedersen, D. B.; Hansen, H. N.; Nielsen, J. S.

    2014-01-01

    The layered nature of Additive Manufactured parts, specifically those given from the Fused Deposition Modelling (FDM) process, exhibit a distinct surface definition. The origin of this is from the 2.5D deposition scheme, which leaves the seam between the individual layers clearly visible.[1...

  14. Surface plasmon resonance sensor with dispersionless microfluidics for direct detection of nucleic acids at the low femtomole level

    Czech Academy of Sciences Publication Activity Database

    Špringer, Tomáš; Piliarik, Marek; Homola, Jiří

    2010-01-01

    Roč. 145, č. 1 (2010), s. 588-591 ISSN 0925-4005 R&D Projects: GA AV ČR KAN200670701 Institutional research plan: CEZ:AV0Z20670512 Keywords : microfluidics * surface plasmon resonance * DNA detection Subject RIV: JB - Sensors, Measurment, Regulation Impact factor: 3.368, year: 2010

  15. Surface-Enhanced Resonance Raman Scattering and Visible Extinction Spectroscopy of Copper Chlorophyllin: An Upper Level Chemistry Experiment

    Science.gov (United States)

    Schnitzer, Cheryl S.; Reim, Candace Lawson; Sirois, John J.; House, Paul G.

    2010-01-01

    Advanced chemistry students are introduced to surface-enhanced resonance Raman scattering (SERRS) by studying how sodium copper chlorophyllin (CuChl) adsorbs onto silver colloids (CuChl/Ag) as a function of pH. Using both SERRS and visible extinction spectroscopy, the extent of CuChl adsorption and colloidal aggregation are monitored. Initially at…

  16. Water-level trends and potentiometric surfaces in the Nacatoch Aquifer in northeastern and southwestern Arkansas and in the Tokio Aquifer in southwestern Arkansas, 2014–15

    Science.gov (United States)

    Rodgers, Kirk D.

    2017-09-20

    The Nacatoch Sand in northeastern and southwestern Arkansas and the Tokio Formation in southwestern Arkansas are sources of groundwater for agricultural, domestic, industrial, and public use. Water-level altitudes measured in 51 wells completed in the Nacatoch Sand and 42 wells completed in the Tokio Formation during 2014 and 2015 were used to create potentiometric-surface maps of the two areas. Aquifers in the Nacatoch Sand and Tokio Formation are hereafter referred to as the Nacatoch aquifer and the Tokio aquifer, respectively.Potentiometric surfaces show that groundwater in the Nacatoch aquifer flows southeast toward the Mississippi River in northeastern Arkansas. Groundwater flow direction is towards the south and southeast in Hempstead, Little River, and Nevada Counties in southwestern Arkansas. An apparent cone of depression exists in southern Clark County and likely alters groundwater flow from a regional direction toward the depression.In southwestern Arkansas, potentiometric surfaces indicate that groundwater flow in the Tokio aquifer is towards the city of Hope. Northwest of Hope, an apparent cone of depression exists. In southwestern Pike, northwestern Nevada, and northeastern Hempstead Counties, an area of artesian flow (water levels are at or above land surface) exists.Water-level changes in wells were identified using two methods: (1) linear regression analysis of hydrographs from select wells with a minimum of 20 years of water-level data, and (2) a direct comparison between water-level measurements from 2008 and 2014–15 at each well. Of the six hydrographs analyzed in the Nacatoch aquifer, four indicated a decline in water levels. Compared to 2008 measurements, the largest rise in water levels was 35.14 feet (ft) in a well in Clark County, whereas the largest decline was 14.76 ft in a well in Nevada County, both located in southwestern Arkansas.Of the four hydrographs analyzed in the Tokio aquifer, one indicated a decline in water levels, while

  17. Observation of an electron band above the Fermi level in FeTe0.55Se0.45 from in-situ surface doping

    International Nuclear Information System (INIS)

    Zhang, P.; Ma, J.; Qian, T.; Richard, P.; Ding, H.; Xu, N.; Xu, Y.-M.; Fedorov, A. V.; Denlinger, J. D.; Gu, G. D.

    2014-01-01

    We used in-situ potassium (K) evaporation to dope the surface of the iron-based superconductor FeTe 0.55 Se 0.45 . The systematic study of the bands near the Fermi level confirms that electrons are doped into the system, allowing us to tune the Fermi level of this material and to access otherwise unoccupied electronic states. In particular, we observe an electron band located above the Fermi level before doping that shares similarities with a small three-dimensional pocket observed in the cousin, heavily electron-doped KFe 2−x Se 2 compound.

  18. Improved characterization of root zone soil moisture in land surface models by assimilation of groundwater level data. An example with TerrSysMP.

    Science.gov (United States)

    Hendricks Franssen, Harrie-Jan; Zhang, Hongjuan; Kurtz, Wolfgang; Kollet, Stefan; Vereecken, Harry

    2017-04-01

    Land surface model predictions are affected by uncertainty with respect to parameters, atmospheric forcings and process representation. Therefore, constraining land surface model predictions by assimilation of soil moisture data is of great interest, using techniques like the Ensemble Kalman Filter. Soil moisture is a key variable in land surface models linking the water and energy cycles. However, various studies found that assimilation of remotely sensed soil moisture content improved root zone soil moisture characterization only marginally. In addition, below densely vegetated areas measured remotely sensed soil moisture content is unreliable. In this study, we explored groundwater level data as an additional information source to be used in data assimilation to constrain root zone soil moisture characterization and land surface model predictions. In order to extract as much information as possible from groundwater level data we used the model TerrSysMP, which represents groundwater better than classical land surface models considering lateral subsurface flow, and fully coupled interactions between the vadose zone and groundwater. The assimilation of groundwater level data in integrated hydrological models like TerrSysMP is challenging. If groundwater level data are assimilated in terms of pressure information and used to update pressure in the vadose zone and aquifer, unrealistic updates may be generated in the upper vadose zone during (very) dry conditions as probability density functions of pressure are highly skewed. On the other hand, if groundwater level data are assimilated in terms of soil moisture values (equal to porosity in the aquifer) and used to update soil moisture in the vadose zone, under specific conditions which we will detail in the presentation updating also does not work well. We tested different data assimilation strategies in synthetic experiments and found that assimilating groundwater level data in terms of pressure, but updating model

  19. Possibility of 1-nm level localization of a single molecule with gap-mode surface-enhanced Raman scattering

    International Nuclear Information System (INIS)

    Choi, Han Kyu; Kim, Zee Hwan

    2015-01-01

    The electromagnetic (EM) enhancement mechanism of surface-enhanced Raman scattering (SERS) has been well established through 30 years of extensive investigation: molecules adsorbed on resonantly driven silver or gold nanoparticles (NPs) experience strongly enhanced field and thus show enhanced Raman scattering. Even stronger SERS enhancement is possible with a gap structure in which two or more NPs form assemblies with gap sizes of 1 nm or less. We have theoretically shown that the measurement of SERS angular distribution can reveal the position of a single molecule near the gap with 1-nm accuracy, even though the spatial extent of the enhanced field is ~10 nm. Real implementation of such experiment requires extremely well-defined (preferably a single crystal) dimeric junctions. Nevertheless, the experiment will provide spatial as well as frequency domain information on single-molecule dynamics at metallic surfaces

  20. Occupational levels of radiation exposure induce surface expression of interleukin-2 receptors in stimulated human peripheral blood lymphocytes

    International Nuclear Information System (INIS)

    Xu Yindong; Greenstock, C.L.; Trivedi, A.; Mitchel, R.E.J.

    1996-01-01

    Interleukin-2 (IL-2) is a cytokine responsible for a variety of immune and non-immune stimulatory and regulatory functions, including the activation and stimulation of cytotoxic cells able to recognize and kill human tumour cells and T-cell proliferation and differentiation. We show that low doses of radiation, in the range commonly received by atomic radiation workers or as a result of minor medical diagnostic procedures (0.25 to 10 mGy), stimulate the expression of IL-2 receptors (IL-2R) on the surface of peripheral blood lymphocytes (PBL) taken from normal human donors. This stimulated surface expression after in vitro irradiation is an indirect effect, resulting from the secretion into the medium of a soluble factor from the irradiated cells. This factor can also stimulate IL-2R surface expression in unirradiated cells. Consequently, radiation stimulation of IL-2R expression in a large population of PBL shows a triggered-type response rather than being proportional to dose. These results demonstrate that normal human cells can respond to doses of radiation in the range of common occupational or medical exposures. The data also demonstrate a possible defence mechanism against environmental stress by which a radiation-exposed cell can use an indirect signalling mechanism to communicate with and influence the biological processes in an unexposed cell. (orig.). With 1 fig., 4 tabs

  1. Differences in activity level between cownose rays (Rhinoptera bonasus) and Atlantic stingrays (Dasyatis sabina) are related to differences in heart mass, hemoglobin concentration, and gill surface area.

    Science.gov (United States)

    Grim, Jeffrey M; Ding, A Adam; Bennett, Wayne A

    2012-10-01

    Aquatic animals are faced with the challenge of extracting oxygen from water, a medium that is metabolically expensive to ventilate and that contains just a fraction of the oxygen concentration relative to air, yet the physiologies of fishes have evolved to support a wide range of activity levels in nature. Oxygen delivery components, including gill surface area (oxygen uptake), blood chemistry (oxygen transport), and the heart (system pump), have been positively correlated to activity level in teleost fishes, yet relatively little is known about how these components are related to activity in elasmobranches. The current study addresses this question by examining heart mass, hemoglobin concentration, hematocrit level, and gill surface area in wild-caught representatives of the benthic Atlantic stingray (Dasyatis sabina) and active cownose ray (Rhinoptera bonasus). Allometric scaling exponents are similar for all four measures between the study species. Heart mass, gill surfaces areas, and hemoglobin concentrations were 2.1 times, approximately 7.1 times, and 2.0 times higher, respectively, in active cownose rays, when compared to benthic Atlantic stingrays, after correcting for differences in body mass. When considered in the context of functional plasticity within the oxygen delivery systems of benthic and active species, data from the current study indicate that higher activity levels in cownose rays are supported by modifications that, at least in part, are likely to enhance oxygen uptake.

  2. Relict benthic foraminifera in surface sediments off central east coast of India as indicator of sea level changes

    Digital Repository Service at National Institute of Oceanography (India)

    Rana, S.S.; Nigam, R.; Panchang, R.

    of micropaleontologists, in: Recent developments in Indian micropaleontology, Special Volume no. 6, edited by P. Kundal, (Gondwana Geological Magazine, Nagpur) 2003, pp. 1-3. 3 Bruckner H, Late Quaternary shorelines in India, in: Late Quaternary sea level correlation...

  3. Clinical Characteristics and Correlation Analysis of Subjects with Chronic Hepatitis B Virus (HBV) Infection and Sustained Low Levels of Hepatitis B Surface Antigen (HBsAg)

    Science.gov (United States)

    Cheng, Jun; Dai, Yuzhu; Yan, Li; Zhou, Huajun; Xu, Xujian

    2018-01-01

    Background The aim of this study was to investigate the clinical characteristics of individuals with chronic hepatitis B virus (HBV) infection with persistent low levels of hepatitis B surface antigen (HBsAg) and to undertake a correlation analysis of the clinical characteristics. Material/Methods The study included 1,204 subjects with chronic HBV infection. Serum HBsAg, HBV envelope antigen (HBeAg), and HBV core antigen (HBcAg) levels were measured using the chemiluminescent microparticle immunoassay (CMIA) and the neutralization test. HBV DNA was measured using real-time fluorescence quantitative polymerase chain reaction (RT-FQ-PCR). Results There were 1,023 subjects in the high-level HBsAg group (HBsAg level ≥10 IU/mL) and 181 subjects in the low-level HBsAg group (HBsAg level HBV-M2), and the asymptomatic carrier (ASC) status was 98.34%. The low-level HBsAg group had a lower HBV DNA-positive rate compared with the high-level HBsAg group (40.33% vs. 75.07%), with a normal distribution across all age groups (P>0.05). The low-level HBsAg group included an older age group. A low-level of HBsAg was positively correlated with a low level of replication of HBV DNA (r=0.452). Conclusions The findings of this study showed that individuals with chronic HBV infection and sustained low-levels of HBsAg were an older population and had a lower level of replicating HBV DNA when compared with individuals with high levels of HBsAg, and the majority (93.7%) were also HBsAg and HBeAg and HBcAg-positive. PMID:29593208

  4. GHRSST Level 2P Global 1m Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the MetOp-B satellite produced by NAVO (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A global Group for High Resolution Sea Surface Temperature (GHRSST) Level 2P dataset based on multi-channel sea surface temperature (SST) retrievals generated in...

  5. GHRSST Level 2P Global 1m Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-19 satellite produced by NAVO (GDS versions 1 and 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A global Group for High Resolution Sea Surface Temperature (GHRSST) Level 2P dataset based on multi-channel sea surface temperature (SST) retrievals generated in...

  6. GHRSST Level 2P Global 1m Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-18 satellite produced by NAVO (GDS versions 1 and 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A global Group for High Resolution Sea Surface Temperature (GHRSST) Level 2P dataset based on multi-channel sea surface temperature (SST) retrievals generated in...

  7. GHRSST Level 2P Regional 1m Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-19 satellite produced by NAVO (GDS versions 1 and 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A regional Group for High Resolution Sea Surface Temperature (GHRSST) Level 2P dataset based on multi-channel sea surface temperature (SST) retrievals generated in...

  8. GHRSST Level 2P Global skin Sea Surface Temperature from the Infrared Atmospheric Sounding Interferometer (IASI) on the Metop-A satellite (GDS V2) produced by OSI SAF (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A global 1 km Group for High Resolution Sea Surface Temperature (GHRSST) Level 2P dataset based on multi-channel sea surface temperature (SST) retrievals generated...

  9. GHRSST Level 2P Global skin Sea Surface Temperature from the Infrared Atmospheric Sounding Interferometer (IASI) on the Metop-B satellite (GDS V2) produced by OSI SAF (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) Level 2P dataset based on multi-channel sea surface temperature (SST) retrievals generated in real-time...

  10. GHRSST Level 2P Global Skin Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the MetOp-A satellite produced by EUMETSAT (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A global 1 km Group for High Resolution Sea Surface Temperature (GHRSST) Level 2P dataset based on multi-channel sea surface temperature (SST) retrievals generated...

  11. GHRSST Level 2P Global 1m Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the MetOp-A satellite produced by NAVO (GDS versions 1 and 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A global Group for High Resolution Sea Surface Temperature (GHRSST) Level 2P dataset based on multi-channel sea surface temperature (SST) retrievals generated in...

  12. GHRSST Level 2P sub-skin Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on Metop satellites (currently Metop-A) (GDS V2) produced by OSI SAF (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A global 1 km Group for High Resolution Sea Surface Temperature (GHRSST) Level 2P dataset based on multi-channel sea surface temperature (SST) retrievals generated...

  13. GHRSST Level 2P sub-skin Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on Metop satellites (currently Metop-B) (GDS V2) produced by OSI SAF (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A global 1 km Group for High Resolution Sea Surface Temperature (GHRSST) Level 2P dataset based on multi-channel sea surface temperature (SST) retrievals generated...

  14. Coherence between interannual variability of sea level with some surface met-ocean parameters at Cochin, southwest coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Srinivas, K.

    Centre, Cochin - 682 014, Kerala, India [ E-mail: srinivas_kantha@rediffmail.com ; srinivas_kantha@yahoo.co.in ] Received 4 October 2001, revised 14 June 2002 The interannual coherence of some surface met-ocean parameters (viz. SST, air temperature....01354, 0.01968 and 0.01428 dyne/cm 2 , respectively. As the numerical values of the observed wind stress are small, the re- siduals (i.e. anomalies) are still smaller. Further, the seasonal signal component in the cross-shore and along-shore wind stress...

  15. CpG Oligodeoxynucleotides Enhance the Activities of CD8+Cytotoxic T-Lymphocytes Generated by Combined hMUC1 Vaccination and hNIS Radioiodine Gene Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, Yong Hyun; Choi, Yun; Kim, Chul Woo; Chung, June Key [Seoul National University College of Medicine, Seoul (Korea, Republic of); Lee, Jaetae [Kyungpook National University, Daegu (Korea, Republic of)

    2010-09-15

    The authors evaluated whether the cytotoxicity of CD8+CTLs generated by combined hMUC1 vaccination and hNIS radioiodine gene therapy was enhanced in the presence of CpG in an established tumor model. CMNF cells (CT26 cells expressing hMUC1, hNIS and Firefly luciferase) were transplanted into BALB/c mice. Four and 10 days later, tumor-bearing mice were immunized intramuscularly with pcDNA3.1 or pcDNA-hMUC1 or pcDNA-hMUC1+CpG, and subsequently administered PBS or {sup 131}I [five groups (seven mice/group): referred to as the pcDNA3.1+PBS, phMUC1+PBS, pcDNA3.1+{sup 131}I, phMUC1+{sup 131}I, and phMUC1+{sup 131}I+CpG groups]. The number of CD8+IFNr+ T cells of splenocytes as well as the number of CD8+IFNr+ T cells of splenocytes re-stimulated with CD11c+ cells was determined using FACS analysis. The activities of cytotoxic T cells (CTLs) from splenocytes were investigated. Marked tumor growth inhibition was observed in the phMUC1+{sup 131}I and phMUC1+{sup 131}I+CpG groups, but not in the other three single therapy groups. Particularly the number of CD8+IFN-{gamma}+ T cells of splenocytes was more increased in the phMUC1+{sup 131}I+CpG group than in the phMUC1+{sup 131}I group. The number of CD8+IFN-{gamma}+ T cells of splenocytes stimulated with CD11c+ cells was the most enhanced in the phMUC1+{sup 131}I+CpG group among the five groups. Concurrently, the activities of hMUC1-associated CTLs obtained from splenocytes in the phMUC1+{sup 131}I+CpG group were significantly greater than in the other four groups(pcDNA+PBS, phMUC1+PBS, pcDNA+{sup 131}I, phMUC1+{sup 131}I, and phMUC1+{sup 131}I+CpG, 16{+-}2%, 20{+-}1%, 30{+-}2%, 60{+-}2%, and 87{+-}2%, respectively, P<0.01). Our data suggest that adjuvant CpG ODNs can increase the killing activities of CTLs generated by combined hMUC1 DNA vaccination and hNIS radioiodine gene therapy.

  16. Study of silicon-silicon nitride interface properties on planar (1 0 0), planar (1 1 1) and textured surfaces using deep-level transient spectroscopy

    International Nuclear Information System (INIS)

    Gong, Chun; Simoen, Eddy; Posthuma, Niels E; Van Kerschaver, Emmanuel; Poortmans, Jef; Mertens, Robert

    2010-01-01

    Deep-level transient spectroscopy (DLTS) has been applied to metal-insulator-semiconductor (MIS) capacitors fabricated on planar (1 0 0), planar (1 1 1) orientations and textured n-type silicon wafers. Low frequency direct plasma-enhanced chemical vapour deposition Si-SiN x interface properties with and without plasma NH 3 pre-treatment, with and without rapid thermal annealing (RTA) have been investigated. It is shown that three different kinds of defect states are identified at the Si-SiN x interface. For the planar (1 0 0) surface, samples with plasma NH 3 pre-treatment plus RTA show the lowest DLTS signals, which suggests the lowest overall interface states density. For planar (1 1 1) Si surfaces, plasma NH 3 pre-treatment and RTA yield a small improvement. With the textured surface, the RTA step improves the surface passivation quality further but no obvious impact is found with plasma NH 3 pre-treatment. Energy-dependent electron capture cross sections were also measured by small-pulse DLTS. The capture cross sections depend strongly on the energy level and decrease towards the conduction band edge.

  17. Surface-enhanced Raman scattering detection of bacteria on microarrays at single cell levels using silver nanoparticles

    International Nuclear Information System (INIS)

    Zhou, Haibo; Yang, Danting; Mircescu, Nicoleta E.; Ivleva, Natalia P.; Schwarzmeier, Kathrin; Niessner, Reinhard; Haisch, Christoph; Wieser, Andreas; Schubert, Sören

    2015-01-01

    We describe a method for the synthesis of SERS-active silver nanoparticles (AgNPs) directly on the surface of bacteria (bacteria-AgNPs), specifically of E. coli cells. This straightforward strategy allows for the sensitive determination of bacteria on a microarray platform. Antibodies were used as selective receptors on the microarray surface. The Raman signal of bacteria-AgNPs is about 10 times higher than that obtained previously with microarrays based on mixing bacteria and AgNPs (bacteria+AgNPs). The optimum SERS enhancement of bacteria-AgNPs is obtained under 633-nm laser excitation, and this most likely is due to the plasmonic interaction of aggregated AgNPs. The method allows for an identification and quantification even of single E. coli bacteria. In our perception, this straightforward approach represents a most valuable tool for the detection of E. coli and, conceivably, of other bacteria, and thus has a large potential in environmental monitoring, medical diagnosis, and in food safety and quality control. (author)

  18. Lathe leveler

    Science.gov (United States)

    Lovelady, III, Michael W.J.

    2018-03-06

    A lathe leveler for centering a cutting tool in relation to a cylindrical work piece includes a first leveling arm having a first contact point disposed adjacent a distal end of the first leveling arm, a second leveling arm having a second contact point disposed adjacent a distal end of the second leveling arm, a leveling gage, and a leveling plate having a cutting tool receiving surface positioned parallel to a horizontal axis of the leveling gage and on a same plane as a midpoint of the first contact point and the second contact point. The leveling arms and leveling plate are dimensioned and configured such that the cutting tool receiving surface is centered in relation to the work piece when the first and second contact points are in contact with one of the inner surface and outer surface of the cylindrical work piece and the leveling gage is centered.

  19. Use of high resolution images of orbital surface of waterproofing with different levels of urban land: case Irati-PR

    Directory of Open Access Journals (Sweden)

    Paulo Costa de Oliveira Filho

    2012-11-01

    Full Text Available The objective of this research was to present a detailed diagnosis for use and occupation of urban land aimed at different levels of sealing, in a downtownIrati area of 14 blocks, totaling 0.23 km2, from the Quickbird satellite images with spatial resolution of 0.60 m, by the method of interpretation and vectorization on the screen followed by classification. The area occupied by the classes that represent the highest level of waterproof is 33,218% of the total study area, since the area occupied by classes representing less impermeable level is 22,488% of the same area. The results show that the study area is well sealed.

  20. vanA Gene Harboring Enterococcal and Non-enterococcal Isolates Expressing High Level Vancomycin and Teicoplanin Resistance Reservoired in Surface Waters.

    Science.gov (United States)

    Nakipoğlu, Mustafa; Yilmaz, Fadime; Icgen, Bulent

    2017-05-01

    Untreated wastewaters and treated effluents even after final disinfection contain antibiotic resistant bacteria and resistance genes before they are released into surface waters. A correlation between resistant bacteria and antibiotics in surface waters has been found, as have antibiotic resistance genes. Of particular interest are vancomycin-resistant enterococci harboring vanA gene that confers high level of resistance to glycopeptide antibiotics including teicoplanin. Therefore, in this study, river water samples were analysed to investigate vancomycin- and teicoplanin-resistant bacterial isolates harboring vanA gene. Out of 290, 15 surface water isolates displayed resistance to both antibiotics. These glycopeptide resistant enterococcal and non-enterococcal isolates, identified by 16S rRNA sequencing, were found to harbor vanA gene with sequence similarities of 50 % to 100 %. The presence of D-alanine-D-lactate ligase encoded by vanA gene was also shown for all vancomycin- and teicoplanin-resistant isolates through western blot analysis. Due to reuse of treated wastewater and release of untreated wastewaters to water bodies, antibiotic resistant bacteria and resistance genes are being introduced into surface waters and present human health risks. Therefore, surface waters are not only hot spots for vanA harboring enterococcal isolates but also non-enterococcal isolates due to gene dissemination and require special scientific consideration.

  1. Acceleration of Upper Trunk Coordination in Young Versus old Adults During Walking on the Level and Irregular Floor Surface Using MTx Sensor

    Directory of Open Access Journals (Sweden)

    Manijeh Soleimanifar

    2015-09-01

    Full Text Available Objectives: To evaluate the reliability of head and trunk acceleration measured by MTx sensors during walking on Level and Irregular surfaces and to compare the differences between healthy young and old adults. Methods: Participants were 20 young female university students and 20 non-faller elderly women in Iran, 2013. Two MTX sensors were used to measure head and trunk accelerations in the vertical (VT, anterior-posterior (AP, and medial-lateral (ML directions while participants walked on a 7-meter walkway.  Results: ICC values in young group were higher as compared to non- faller elderly group; ICC was greater than 0.7 for 89.47%(34.38 of variables in young group and for 60.52%(23.38 in non- faller. Intersession reliability for upper trunk coordination indices in regular surface and in young group showed highest values as compared with other conditions in both groups, whereas the lowest intersession reliability was found in irregular floor surface indices in non-faller elderly group. Discussion: The calculated ICC, SEM, CV%, MDC values suggest that the MTX sensors provide precise recordings and detect small changes in upper  trunk accelerometric parameters. ICC values were influenced by the age and the floor condition. In healthy young, all ICC values in regular surface were higher than 0.7. Floor condition effect was noticeable in elderly especially in ML direction. During walking on irregular surface, ML acceleration, velocity and harmonic  ratio in elderly showed lower repeatability.

  2. A Statistical Analysis of the Relationship between Brown Haze and Surface Air Pollution Levels on Respiratory Hospital Admissions in Auckland, New Zealand

    OpenAIRE

    Kim Natasha Dirks; James Scarfe; Nicholas Philip Talbot; Roger Marshall; Jennifer Anne Salmond

    2017-01-01

    Eleven years of hospital admissions data for Auckland, New Zealand for respiratory conditions are analyzed using a Poisson regression modelling approach, incorporating a spline function to represent time, based on a detailed record of haze events and surface air pollution levels over an eleven-year period, taking into account the daily average temperature and humidity, the day of the week, holidays and trends over time. NO2 was the only pollutant to show a statistically significant increase (...

  3. Insecticide-treated bed nets reduce plasma antibody levels and limit the repertoire of antibodies to Plasmodium falciparum variant surface antigens

    DEFF Research Database (Denmark)

    Askjaer, N; Maxwell, C; Chambo, W

    2001-01-01

    The use of insecticide-treated bed nets (ITN) has been documented to reduce malaria morbidity and mortality in areas with endemic malaria, but concerns have been raised that ITN usage could affect the acquisition of malaria immunity. Several lines of evidence have indicated that antibodies against...... variant surface antigens (VSA) are important in the development of naturally acquired immunity to Plasmodium falciparum malaria and may thus be good indicators of immune status. We have compared the levels of VSA antibodies in plasma from children who have used ITN for 4 years to levels in plasma from...

  4. Using LiDAR and remote microclimate loggers to downscale near-surface air temperatures for site-level studies

    Science.gov (United States)

    Andrew D. George; Frank R. Thompson; John. Faaborg

    2015-01-01

    A spatial mismatch exists between regional climate models and conditions experienced by individual organisms. We demonstrate an approach to downscaling air temperatures for site-level studies using airborne LiDAR data and remote microclimate loggers. In 2012-2013, we established a temperature logger network in the forested region of central Missouri, USA, and obtained...

  5. Performance assessment and licensing issues for United States commercial near-surface low-level radioactive waste disposal facilities

    International Nuclear Information System (INIS)

    Birk, S.M.

    1997-10-01

    The final objective of performance assessment for a near-surface LLW disposal facility is to demonstrate that potential radiological impacts for each of the human exposure pathways will not violate applicable standards. This involves determining potential pathways and specific receptor locations for human exposure to radionuclides; developing appropriate scenarios for each of the institutional phases of a disposal facility; and maintaining quality assurance and control of all data, computer codes, and documentation. The results of a performance assessment should be used to demonstrate that the expected impacts are expected to be less than the applicable standards. The results should not be used to try to predict the actual impact. This is an important distinction that results from the uncertainties inherent in performance assessment calculations. The paper discusses performance objectives; performance assessment phases; scenario selection; mathematical modeling and computer programs; final results of performance assessments submitted for license application; institutional control period; licensing issues; and related research and development activities

  6. Low-Computation Strategies for Extracting CO2 Emission Trends from Surface-Level Mixing Ratio Observations

    Science.gov (United States)

    Shusterman, A.; Kim, J.; Lieschke, K.; Newman, C.; Cohen, R. C.

    2017-12-01

    Global momentum is building for drastic, regulated reductions in greenhouse gas emissions over the coming decade. With this increasing regulation comes a clear need for increasingly sophisticated monitoring, reporting, and verification (MRV) strategies capable of enforcing and optimizing emissions-related policy, particularly as it applies to urban areas. Remote sensing and/or activity-based emission inventories can offer MRV insights for entire sectors or regions, but are not yet sophisticated enough to resolve unexpected trends in specific emitters. Urban surface monitors can offer the desired proximity to individual greenhouse gas sources, but due to the densely-packed nature of typical urban landscapes, surface observations are rarely representative of a single source. Most previous efforts to decompose these complex signals into their contributing emission processes have involved inverse atmospheric modeling techniques, which are computationally intensive and believed to depend heavily on poorly understood a priori estimates of error covariance. Here we present a number of transparent, low-computation approaches for extracting source-specific emissions estimates from signals with a variety of nearfield influences. Using observations from the first several years of the BErkeley Atmospheric CO2 Observation Network (BEACO2N), we demonstrate how to exploit strategic pairings of monitoring "nodes," anomalous wind conditions, and well-understood temporal variations to hone in on specific CO2 sources of interest. When evaluated against conventional, activity-based bottom-up emission inventories, these strategies are seen to generate quantitatively rigorous emission estimates. With continued application as the BEACO2N data set grows in time and space, these approaches offer a promising avenue for optimizing greenhouse gas mitigation strategies into the future.

  7. Computational studies at the density functional theory (DFT) level about the surface functionalization of hexagonal monolayers by chitosan monomer

    Science.gov (United States)

    Ebrahimi, Javad; Ahangari, Morteza Ghorbanzadeh; Jahanshahi, Mohsen

    2018-05-01

    Theoretical investigations based on density functional theory have been carried out to understand the underlying interactions between the chitosan monomer and several types of hexagonal monolayers consisting of pristine and defected graphene and boron-nitride nanosheets. Based on the obtained results, it was found that the type of the interaction for all the systems is of non-covalent nature and the chitosan monomer physically interacts with the surface of mentioned nanostructures. The interaction strength was evaluated by calculating the adsorption energies for the considered systems and it was found that the adsorption of chitosan monomer accompanies by the release of about -0.67 and -0.66 eV energy for pristine graphene and h-BN monolayer, respectively. The role of structural defect has also been considered by embedding a Stone-Wales defect within the structure of mentioned monolayers and it was found that the introduced defect enhances the interactions between the chitosan monomer and nanostructures. The role of dispersion interactions has also been taken into account and it was found that these long-range interactions play the dominating role in the attachment of chitosan monomer onto the graphene sheet, while having strong contribution together with the electrostatic interactions for the stabilization of chitosan onto the surface of h-BN monolayer. For all the cases, the adsorption of chitosan monomer did not change the inherent electronic properties of the nanostructures based on the results of charge transfer analysis and energy gap calculations. The findings of the present work would be very useful in future investigations to explore the potential applications of these hybrid materials in materials science and bio-related fields.

  8. Quantifying phosphorus levels in soils, plants, surface water, and shallow groundwater associated with bahiagrass-based pastures.

    Science.gov (United States)

    Sigua, Gilbert C; Hubbard, Robert K; Coleman, Samuel W

    2010-01-01

    Recent assessments of water quality status have identified eutrophication as one of the major causes of water quality 'impairment' not only in the USA but also around the world. In most cases, eutrophication has accelerated by increased inputs of phosphorus due to intensification of crop and animal production systems since the early 1990 s. Despite substantial measurements using both laboratory and field techniques, little is known about the spatial and temporal variability of phosphorus dynamics across landscapes, especially in agricultural landscapes with cow-calf operations. Critical to determining environmental balance and accountability is an understanding of phosphorus excreted by animals, phosphorus removal by plants, acceptable losses of phosphorus within the manure management and crop production systems into soil and waters, and export of phosphorus off-farm. Further research effort on optimizing forage-based cow-calf operations to improve pasture sustainability and protect water quality is therefore warranted. We hypothesized that properly managed cow-calf operations in subtropical agroecosystem would not be major contributors to excess loads of phosphorus in surface and ground water. To verify our hypothesis, we examined the comparative concentrations of total phosphorus among soils, forage, surface water, and groundwater beneath bahiagrass-based pastures with cow-calf operations in central Florida, USA. Soil samples were collected at 0-20; 20-40, 40-60, and 60-100 cm across the landscape (top slope, middle slope, and bottom slope) of 8 ha pasture in the fall and spring of 2004 to 2006. Forage availability and phosphorus uptake of bahiagrass were also measured from the top slope, middle slope, and bottom slope. Bi-weekly (2004-2006) groundwater and surface water samples were taken from wells located at top slope, middle slope, and bottom slope, and from the runoff/seepage area. Concentrations of phosphorus in soils, forage, surface water, and shallow

  9. Monitoring Water Surface and Level of a Reservoir Using Different Remote Sensing Approaches and Comparison with Dam Displacements Evaluated via GNSS

    Directory of Open Access Journals (Sweden)

    Claudia Pipitone

    2018-01-01

    Full Text Available Remote sensing allowed monitoring the reservoir water level by estimating its surface extension. Surface extension has been estimated using different approaches, employing both optical (Landsat 5 TM, Landsat 7 ETM+ SLC-Off, Landsat 8 OLI-TIRS and ASTER images and Synthetic Aperture Radar (SAR images (Cosmo SkyMed and TerraSAR-X. Images were characterized by different acquisition modes, geometric and spectral resolutions, allowing the evaluation of alternative and/or complementary techniques. For each kind of image, two techniques have been tested: The first based on an unsupervised classification and suitable to automate the process, the second based on visual matching with contour lines with the aim of fully exploiting the dataset. Their performances were evaluated by comparison with water levels measured in situ (r2 = 0.97 using the unsupervised classification, r2 = 0.95 using visual matching demonstrating that both techniques are suitable to quantify reservoir surface extension. However ~90% of available images were analyzed using the visual matching method, and just 37 images out of 58 using the other method. The evaluation of the water level from the water surface, using both techniques, could be easily extended to un-gauged reservoirs to manage the variations of the levels during normal operation. In addition, during the period of investigation, the use of Global Navigation Satellite System (GNSS allowed the estimation of dam displacements. The advantage of using as reference a GNSS permanent station positioned relatively far from the dam, allowed the exclusion of any interaction with the site deformations. By comparing results from both techniques, relationships between the orthogonal displacement component via GNSS, estimated water levels via remote sensing and in situ measurements were investigated. During periods of changing water level (April 2011–September 2011 and October 2011–March 2012, the moving average of displacement time

  10. [Jānis Keruss, Ineta Lipša, Inese Runce, Kaspars Zellis. Latvijas Universitātes Vēstures un filozofijas fakultātes vēsture padomju laikā: personības, struktūras, idejas (1944-1991)] / Kristine Wohlfart

    Index Scriptorium Estoniae

    Wohlfart, Kristine, 1968-

    2012-01-01

    Arvustus: Keruss, Jānis, Lipša, Ineta, Runce, Inese, Zellis, Kaspars. Latvijas Universitātes Vēstures un filozofijas fakultātes vēsture padomju laikā: personības, struktūras, idejas (1944-1991). (Riga. LU Akadēmiskais apgāds, 2010)

  11. Surface Electrical Stimulation for Treating Swallowing Disorders after Stroke: A Review of the Stimulation Intensity Levels and the Electrode Placements

    Directory of Open Access Journals (Sweden)

    Marziyeh Poorjavad

    2014-01-01

    Full Text Available Neuromuscular electrical stimulation (NMES for treating dysphagia is a relatively new therapeutic method. There is a paucity of evidence about the use of NMES in patients with dysphagia caused by stroke. The present review aimed to introduce and discuss studies that have evaluated the efficacy of this method amongst dysphagic patients following stroke with emphasis on the intensity of stimulation (sensory or motor level and the method of electrode placement on the neck. The majority of the reviewed studies describe some positive effects of the NMES on the neck musculature in the swallowing performance of poststroke dysphagic patients, especially when the intensity of the stimulus is adjusted at the sensory level or when the motor electrical stimulation is applied on the infrahyoid muscles during swallowing.

  12. Surface ozone and carbon monoxide levels observed at Oki, Japan: regional air pollution trends in East Asia.

    Science.gov (United States)

    Sikder, Helena Akhter; Suthawaree, Jeeranut; Kato, Shungo; Kajii, Yoshizumi

    2011-03-01

    Simultaneous ground-based measurements of ozone and carbon monoxide were performed at Oki, Japan, from January 2001 to September 2002 in order to investigate the O(3) and CO characteristics and their distributions. The observations revealed that O(3) and CO concentrations were maximum in springtime and minimum in the summer. The monthly averaged concentrations of O(3) and CO were 60 and 234 ppb in spring and 23 and 106 ppb in summer, respectively. Based on direction, 5-day isentropic backward trajectory analysis was carried out to determine the transport path of air masses, preceding their arrival at Oki. Comparison between classified results from present work and results from the year 1994-1996 was carried out. The O(3) and CO concentration results of classified air masses in our analysis show similar concentration trends to previous findings; highest in the WNW/W, lowest in N/NE and medium levels in NW. Moreover, O(3) levels are higher and CO levels are lower in the present study in all categories. Copyright © 2010 Elsevier Ltd. All rights reserved.

  13. LDRD final report : on the development of hybrid level-set/particle methods for modeling surface evolution during feature-scale etching and deposition processes

    International Nuclear Information System (INIS)

    McBride, Cory L.; Schmidt, Rodney Cannon; Musson, Lawrence Cale

    2005-01-01

    Two methods for creating a hybrid level-set (LS)/particle method for modeling surface evolution during feature-scale etching and deposition processes are developed and tested. The first method supplements the LS method by introducing Lagrangian marker points in regions of high curvature. Once both the particle set and the LS function are advanced in time, minimization of certain objective functions adjusts the LS function so that its zero contour is in closer alignment with the particle locations. It was found that the objective-minimization problem was unexpectedly difficult to solve, and even when a solution could be found, the acquisition of it proved more costly than simply expanding the basis set of the LS function. The second method explored is a novel explicit marker-particle method that we have named the grid point particle (GPP) approach. Although not a LS method, the GPP approach has strong procedural similarities to certain aspects of the LS approach. A key aspect of the method is a surface rediscretization procedure--applied at each time step and based on a global background mesh--that maintains a representation of the surface while naturally adding and subtracting surface discretization points as the surface evolves in time. This method was coded in 2-D, and tested on a variety of surface evolution problems by using it in the ChISELS computer code. Results shown for 2-D problems illustrate the effectiveness of the method and highlight some notable advantages in accuracy over the LS method. Generalizing the method to 3D is discussed but not implemented

  14. Low-level multicounter β/γ systems with external guards in surface and shallow underground laboratories

    International Nuclear Information System (INIS)

    Theodorsson, P.

    1997-01-01

    When weak samples are measured it is important that they can be given ample counting time in order to obtain satisfactory accuracy and that the background count rate can be checked well. This calls for a high counting capacity, which multidetectors can bring us. I will discuss development possibilities of low-level β/γ multidetector systems with an external anticosmic shield that will in many cases be operated in underground laboratories. These simple and low-cost system can frequently help us in increasing the number of detectors. Three concepts are combined in these systems: (1) multidetectors, (2) an external anticosmic (or guard) detector arrangement and (3) overburden shielding. (orig.)

  15. Low-level multicounter {beta}/{gamma} systems with external guards in surface and shallow underground laboratories

    Energy Technology Data Exchange (ETDEWEB)

    Theodorsson, P. [Iceland Univ. (Iceland). Science Inst.

    1997-03-01

    When weak samples are measured it is important that they can be given ample counting time in order to obtain satisfactory accuracy and that the background count rate can be checked well. This calls for a high counting capacity, which multidetectors can bring us. I will discuss development possibilities of low-level {beta}/{gamma} multidetector systems with an external anticosmic shield that will in many cases be operated in underground laboratories. These simple and low-cost system can frequently help us in increasing the number of detectors. Three concepts are combined in these systems: (1) multidetectors, (2) an external anticosmic (or guard) detector arrangement and (3) overburden shielding. (orig.)

  16. High levels of serum antibodies to merozoite surface protein 2 of Plasmodium falciparum are associated with reduced risk of clinical malaria in coastal Kenya.

    Science.gov (United States)

    Polley, Spencer D; Conway, David J; Cavanagh, David R; McBride, Jana S; Lowe, Brett S; Williams, Thomas N; Mwangi, Tabitha W; Marsh, Kevin

    2006-05-08

    The merozoite surface protein (MSP) 2 is a vaccine candidate antigen of Plasmodium falciparum that is polymorphic in natural populations. In a prospective cohort study in two coastal populations of Kenya using recombinant proteins derived from the two major allelic types of MSP2, high serum levels of IgG to MSP2 were associated with protection from clinical malaria. This protection was independent of that associated with antibodies to another vaccine candidate antigen (AMA1) in these populations. However, low antibody levels to MSP2 appeared to be associated with increased susceptibility to malaria within people who were parasite negative at the time of serum collection. These data suggest that an MSP2 based vaccine should be designed to induce high level antibody responses against the different MSP2 types present globally in P. falciparum populations and that MSP2 could be combined with other P. falciparum antigens to form a multi-component malaria vaccine.

  17. A level set methodology for predicting the effect of mask wear on surface evolution of features in abrasive jet micro-machining

    International Nuclear Information System (INIS)

    Burzynski, T; Papini, M

    2012-01-01

    A previous implementation of narrow-band level set methodology developed by the authors was extended to allow for the modelling of mask erosive wear in abrasive jet micro-machining (AJM). The model permits the prediction of the surface evolution of both the mask and the target simultaneously, by representing them as a hybrid and continuous mask–target surface. The model also accounts for the change in abrasive mass flux incident to both the target surface and, for the first time, the eroding mask edge, that is brought about by the presence of the mask edge itself. The predictions of the channel surface and eroded mask profiles were compared with measurements on channels machined in both glass and poly-methyl-methacrylate (PMMA) targets at both normal and oblique incidence, using tempered steel and elastomeric masks. A much better agreement between the predicted and measured profiles was found when mask wear was taken into account. Mask wear generally resulted in wider and deeper glass target profiles and wider PMMA target profiles, respectively, when compared to cases where no mask wear was present. This work has important implications for the AJM of complex MEMS and microfluidic devices that require longer machining times. (paper)

  18. High-Level Systemic Expression of Conserved Influenza Epitope in Plants on the Surface of Rod-Shaped Chimeric Particles

    Directory of Open Access Journals (Sweden)

    Natalia V. Petukhova

    2014-04-01

    Full Text Available Recombinant viruses based on the cDNA copy of the tobacco mosaic virus (TMV genome carrying different versions of the conserved M2e epitope from influenza virus A cloned into the coat protein (CP gene were obtained and partially characterized by our group previously; cysteines in the human consensus M2e sequence were changed to serine residues. This work intends to show some biological properties of these viruses following plant infections. Agroinfiltration experiments on Nicotiana benthamiana confirmed the efficient systemic expression of M2e peptides, and two point amino acid substitutions in recombinant CPs significantly influenced the symptoms and development of viral infections. Joint expression of RNA interference suppressor protein p19 from tomato bushy stunt virus (TBSV did not affect the accumulation of CP-M2e-ser recombinant protein in non-inoculated leaves. RT-PCR analysis of RNA isolated from either infected leaves or purified TMV-M2e particles proved the genetic stability of TMV‑based viral vectors. Immunoelectron microscopy of crude plant extracts demonstrated that foreign epitopes are located on the surface of chimeric virions. The rod‑shaped geometry of plant-produced M2e epitopes is different from the icosahedral or helical filamentous arrangement of M2e antigens on the carrier virus-like particles (VLP described earlier. Thereby, we created a simple and efficient system that employs agrobacteria and plant viral vectors in order to produce a candidate broad-spectrum flu vaccine.

  19. County-Level Climate Uncertainty for Risk Assessments: Volume 4 Appendix C - Historical Maximum Near-Surface Air Temperature.

    Energy Technology Data Exchange (ETDEWEB)

    Backus, George A.; Lowry, Thomas Stephen; Jones, Shannon M; Walker, La Tonya Nicole; Roberts, Barry L; Malczynski, Leonard A.

    2017-06-01

    This report uses the CMIP5 series of climate model simulations to produce country- level uncertainty distributions for use in socioeconomic risk assessments of climate change impacts. It provides appropriate probability distributions, by month, for 169 countries and autonomous-areas on temperature, precipitation, maximum temperature, maximum wind speed, humidity, runoff, soil moisture and evaporation for the historical period (1976-2005), and for decadal time periods to 2100. It also provides historical and future distributions for the Arctic region on ice concentration, ice thickness, age of ice, and ice ridging in 15-degree longitude arc segments from the Arctic Circle to 80 degrees latitude, plus two polar semicircular regions from 80 to 90 degrees latitude. The uncertainty is meant to describe the lack of knowledge rather than imprecision in the physical simulation because the emphasis is on unfalsified risk and its use to determine potential socioeconomic impacts. The full report is contained in 27 volumes.

  20. County-Level Climate Uncertainty for Risk Assessments: Volume 18 Appendix Q - Historical Maximum Near-Surface Wind Speed.

    Energy Technology Data Exchange (ETDEWEB)

    Backus, George A.; Lowry, Thomas Stephen; Jones, Shannon M; Walker, La Tonya Nicole; Roberts, Barry L; Malczynski, Leonard A.

    2017-06-01

    This report uses the CMIP5 series of climate model simulations to produce country- level uncertainty distributions for use in socioeconomic risk assessments of climate change impacts. It provides appropriate probability distributions, by month, for 169 countries and autonomous-areas on temperature, precipitation, maximum temperature, maximum wind speed, humidity, runoff, soil moisture and evaporation for the historical period (1976-2005), and for decadal time periods to 2100. It also provides historical and future distributions for the Arctic region on ice concentration, ice thickness, age of ice, and ice ridging in 15-degree longitude arc segments from the Arctic Circle to 80 degrees latitude, plus two polar semicircular regions from 80 to 90 degrees latitude. The uncertainty is meant to describe the lack of knowledge rather than imprecision in the physical simulation because the emphasis is on unfalsified risk and its use to determine potential socioeconom ic impacts. The full report is contained in 27 volumes.

  1. County-Level Climate Uncertainty for Risk Assessments: Volume 2 Appendix A - Historical Near-Surface Air Temperature.

    Energy Technology Data Exchange (ETDEWEB)

    Backus, George A.; Lowry, Thomas Stephen; Jones, Shannon M; Walker, La Tonya Nicole; Roberts, Barry L; Malczynski, Leonard A.

    2017-06-01

    This report uses the CMIP5 series of climate model simulations to produce country- level uncertainty distributions for use in socioeconomic risk assessments of climate change impacts. It provides appropriate probability distributions, by month, for 169 countries and autonomous-areas on temperature, precipitation, maximum temperature, maximum wind speed, humidity, runoff, soil moisture and evaporation for the historical period (1976-2005), and for decadal time periods to 2100. It also provides historical and future distributions for the Arctic region on ice concentration, ice thickness, age of ice, and ice ridging in 15-degree longitude arc segments from the Arctic Circle to 80 degrees latitude, plus two polar semicircular regions from 80 to 90 degrees latitude. The uncertainty is meant to describe the lack of knowledge rather than imprecision in the physical simulation because the emphasis is on unfalsified risk and its use to determine potential socioeconomic impacts. The full report is contained in 27 volumes.

  2. County-Level Climate Uncertainty for Risk Assessments: Volume 6 Appendix E - Historical Minimum Near-Surface Air Temperature.

    Energy Technology Data Exchange (ETDEWEB)

    Backus, George A.; Lowry, Thomas Stephen; Jones, Shannon M; Walker, La Tonya Nicole; Roberts, Barry L; Malczynski, Leonard A.

    2017-06-01

    This report uses the CMIP5 series of climate model simulations to produce country- level uncertainty distributions for use in socioeconomic risk assessments of climate change impacts. It provides appropriate probability distributions, by month, for 169 countries and autonomous-areas on temperature, precipitation, maximum temperature, maximum wind speed, humidity, runoff, soil moisture and evaporation for the historical period (1976-2005), and for decadal time periods to 2100. It also provides historical and future distributions for the Arctic region on ice concentration, ice thickness, age of ice, and ice ridging in 15-degree longitude arc segments from the Arctic Circle to 80 degrees latitude, plus two polar semicircular regions from 80 to 90 degrees latitude. The uncertainty is meant to describe the lack of knowledge rather than imprecision in the physical simulation because the emphasis is on unfalsified risk and its use to determine potential socioeconomic impacts. The full report is contained in 27 volumes.

  3. Surface Functionalization of g-C 3 N 4 : Molecular-Level Design of Noble-Metal-Free Hydrogen Evolution Photocatalysts

    KAUST Repository

    Chen, Yin

    2015-06-12

    A stable noble-metal-free hydrogen evolution photocatalyst based on graphite carbon nitride (g-C3N4) was developed by a molecular-level design strategy. Surface functionalization was successfully conducted to introduce a single nickel active site onto the surface of the semiconducting g-C3N4. This catalyst family (with less than 0.1 wt% of Ni) has been found to produce hydrogen with a rate near to the value obtained by using 3 wt% platinum as co-catalyst. This new catalyst also exhibits very good stability under hydrogen evolution conditions, without any evidence of deactivation after 24h. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Energy levels of a quantum particle on a cylindrical surface with non-circular cross-section in electric and magnetic fields

    Science.gov (United States)

    Cruz, Philip Christopher S.; Bernardo, Reginald Christian S.; Esguerra, Jose Perico H.

    2017-04-01

    We calculate the energy levels of a quantum particle on a cylindrical surface with non-circular cross-section in uniform electric and magnetic fields. Using separation of variables method and a change of independent variable, we show that the problem can be reduced to a one-dimensional Schrödinger equation for a periodic potential. The effects of varying the shape of the cross-section while keeping the same perimeter and the strengths of the electric and magnetic fields are investigated for elliptical, corrugated, and nearly-rectangular tubes with radial dimensions of the order of a nanometer. The geometric potential has minima at the angular positions where there is a significant amount of curvature. For the elliptical and corrugated tubes, it is shown that as the tube departs from the circular shape of cross-section the double-degeneracy between the energy levels is lifted. For the nearly-rectangular tube, it is shown that energy level crossings occur as the horizontal dimension of the tube is varied while keeping the same perimeter and radius of circular corners. The interplay between the curvature and the strength of the electric and magnetic fields determines the overall behavior of the energy levels. As the strength of the electric field increases, the overall potential gets skewed creating a potential well on the side corresponding to the more negative electric potential. The energy levels of the first few excited states approach more positive values while the ground state energy level approaches a more negative value. For large electric fields, all bound state energy levels tend to more negative values. The contribution of weak magnetic fields to the overall potential behaves in the same way as the electric field contribution but with its sign depending on the direction of the component of the momentum parallel to the cylindrical axis. Large magnetic fields lead to pairing of energy levels reminiscent of 2D Landau levels for the elliptical and nearly

  5. Energy levels of a quantum particle on a cylindrical surface with non-circular cross-section in electric and magnetic fields

    International Nuclear Information System (INIS)

    Cruz, Philip Christopher S.; Bernardo, Reginald Christian S.; Esguerra, Jose Perico H.

    2017-01-01

    We calculate the energy levels of a quantum particle on a cylindrical surface with non-circular cross-section in uniform electric and magnetic fields. Using separation of variables method and a change of independent variable, we show that the problem can be reduced to a one-dimensional Schrödinger equation for a periodic potential. The effects of varying the shape of the cross-section while keeping the same perimeter and the strengths of the electric and magnetic fields are investigated for elliptical, corrugated, and nearly-rectangular tubes with radial dimensions of the order of a nanometer. The geometric potential has minima at the angular positions where there is a significant amount of curvature. For the elliptical and corrugated tubes, it is shown that as the tube departs from the circular shape of cross-section the double-degeneracy between the energy levels is lifted. For the nearly-rectangular tube, it is shown that energy level crossings occur as the horizontal dimension of the tube is varied while keeping the same perimeter and radius of circular corners. The interplay between the curvature and the strength of the electric and magnetic fields determines the overall behavior of the energy levels. As the strength of the electric field increases, the overall potential gets skewed creating a potential well on the side corresponding to the more negative electric potential. The energy levels of the first few excited states approach more positive values while the ground state energy level approaches a more negative value. For large electric fields, all bound state energy levels tend to more negative values. The contribution of weak magnetic fields to the overall potential behaves in the same way as the electric field contribution but with its sign depending on the direction of the component of the momentum parallel to the cylindrical axis. Large magnetic fields lead to pairing of energy levels reminiscent of 2D Landau levels for the elliptical and nearly

  6. Multi-scale modeling study of the source contributions to near-surface ozone and sulfur oxides levels over California during the ARCTAS-CARB period

    Directory of Open Access Journals (Sweden)

    M. Huang

    2011-04-01

    Full Text Available Chronic high surface ozone (O3 levels and the increasing sulfur oxides (SOx = SO2+SO4 ambient concentrations over South Coast (SC and other areas of California (CA are affected by both local emissions and long-range transport. In this paper, multi-scale tracer, full-chemistry and adjoint simulations using the STEM atmospheric chemistry model are conducted to assess the contribution of local emission sourcesto SC O3 and to evaluate the impacts of transported sulfur and local emissions on the SC sulfur budgetduring the ARCTAS-CARB experiment period in 2008. Sensitivity simulations quantify contributions of biogenic and fire emissions to SC O3 levels. California biogenic and fire emissions contribute 3–4 ppb to near-surface O3 over SC, with larger contributions to other regions in CA. During a long-range transport event from Asia starting from 22 June, high SOx levels (up to ~0.7 ppb of SO2 and ~1.3 ppb of SO4 is observed above ~6 km, but they did not affect CA surface air quality. The elevated SOx observed at 1–4 km is estimated to enhance surface SOx over SC by ~0.25 ppb (upper limit on ~24 June. The near-surface SOx levels over SC during the flight week are attributed mostly to local emissions. Two anthropogenic SOx emission inventories (EIs from the California Air Resources Board (CARB and the US Environmental Protection Agency (EPA are compared and applied in 60 km and 12 km chemical transport simulations, and the results are compared withobservations. The CARB EI shows improvements over the National Emission Inventory (NEI by EPA, but generally underestimates surface SC SOx by about a factor of two. Adjoint sensitivity analysis indicated that SO2 levels at 00:00 UTC (17:00 local time at six SC surface sites were influenced by previous day maritime emissions over the

  7. Energy-level matching of Fe(III) ions grafted at surface and doped in bulk for efficient visible-light photocatalysts.

    Science.gov (United States)

    Liu, Min; Qiu, Xiaoqing; Miyauchi, Masahiro; Hashimoto, Kazuhito

    2013-07-10

    Photocatalytic reaction rate (R) is determined by the multiplication of light absorption capability (α) and quantum efficiency (QE); however, these two parameters generally have trade-off relations. Thus, increasing α without decreasing QE remains a challenging issue for developing efficient photocatalysts with high R. Herein, using Fe(III) ions grafted Fe(III) doped TiO2 as a model system, we present a novel method for developing visible-light photocatalysts with efficient R, utilizing the concept of energy level matching between surface-grafted Fe(III) ions as co-catalysts and bulk-doped Fe(III) ions as visible-light absorbers. Photogenerated electrons in the doped Fe(III) states under visible-light efficiently transfer to the surface grafted Fe(III) ions co-catalysts, as the doped Fe(III) ions in bulk produced energy levels below the conduction band of TiO2, which match well with the potential of Fe(3+)/Fe(2+) redox couple in the surface grafted Fe(III) ions. Electrons in the surface grafted Fe(III) ions efficiently cause multielectron reduction of adsorbed oxygen molecules to achieve high QE value. Consequently, the present Fe(III)-FexTi1-xO2 nanocomposites exhibited the highest visible-light R among the previously reported photocatalysts for decomposition of gaseous organic compounds. The high R can proceed even under commercial white-light emission diode irradiation and is very stable for long-term use, making it practically useful. Further, this efficient method could be applied in other wide-band gap semiconductors, including ZnO or SrTiO3, and may be potentially applicable for other photocatalysis systems, such as water splitting, CO2 reduction, NOx removal, and dye decomposition. Thus, this method represents a strategic approach to develop new visible-light active photocatalysts for practical uses.

  8. Improving the Accuracy of Extracting Surface Water Quality Levels (SWQLs) Using Remote Sensing and Artificial Neural Network: a Case Study in the Saint John River, Canada

    Science.gov (United States)

    Sammartano, G.; Spanò, A.

    2017-09-01

    Delineating accurate surface water quality levels (SWQLs) always presents a great challenge to researchers. Existing methods of assessing surface water quality only provide individual concentrations of monitoring stations without providing the overall SWQLs. Therefore, the results of existing methods are usually difficult to be understood by decision-makers. Conversely, the water quality index (WQI) can simplify surface water quality assessment process to be accessible to decision-makers. However, in most cases, the WQI reflects inaccurate SWQLs due to the lack of representative water samples. It is very challenging to provide representative water samples because this process is costly and time consuming. To solve this problem, we introduce a cost-effective method which combines the Landsat-8 imagery and artificial intelligence to develop models to derive representative water samples by correlating concentrations of ground truth water samples to satellite spectral information. Our method was validated and the correlation between concentrations of ground truth water samples and predicted concentrations from the developed models reached a high level of coefficient of determination (R2) > 0.80, which is trustworthy. Afterwards, the predicted concentrations over each pixel of the study area were used as an input to the WQI developed by the Canadian Council of Ministers of the Environment to extract accurate SWQLs, for drinking purposes, in the Saint John River. The results indicated that SWQL was observed as 67 (Fair) and 59 (Marginal) for the lower and middle basins of the river, respectively. These findings demonstrate the potential of using our approach in surface water quality management.

  9. G-6-PD level and surface nanoscopy: a novel approach in ergonomic stress management of female labours in Bengal suburbs performing manual material handling.

    Science.gov (United States)

    Ghosh, Subrata; Acharyya, Muktish; Bagchi, Anandi

    2009-12-01

    Strenous physical exercise like professional load bearing often produces oxidative stress, increasing post exercise Malondialdehyde (MDA) levels. To quantify the cellular dimension/profile of the said stress, nanoscopic observation of the erythrocyte surface was made by Atomic Forced Microscopy (AFM)/Lateral Forced Microscopy (LFM) and correspondingly the average roughness of the surface was measured. An attempt has been made to correlate the antioxidant vitamin mixture supplementation, endurance capacity, allied physiological parameters and blood glucose-6-phosphate dehydrogenase (G-6-PD) level and roughness-MDA correlation and thereby the deduced regression equation as crucial markers of performance related oxidative stress management in professional female load bearers. Three experimental groups A, B and placebo, each consisting of ten female workers (18-21 years old), were chosen. Group A was given 400 mg of vitamin E supplementation daily, while Group B was given a clinical mixture of vitamin E, vitamin C and beta-carotene daily in capsular form for a period of 28 days. The exercise- induced hike in the status of serum MDA was found to rise less significantly with vitamin supplementation. Further study showed that the supplementation was instrumental in reducing the basal MDA level. Endurance capacity, determined by bicycle ergometric method, was increased more significantly (p material handling.

  10. Surface dust wipes are the best predictors of blood leads in young children with elevated blood lead levels

    Energy Technology Data Exchange (ETDEWEB)

    Gulson, Brian, E-mail: brian.gulson@mq.edu.au [Graduate School of the Environment, Macquarie University, North Ryde NSW 2109 (Australia); CSIRO Earth Science and Resource Engineering, North Ryde NSW 2113 (Australia); Anderson, Phil [Information and Statistics Group, Australian Institute of Health and Welfare, Canberra ACT 2601 (Australia); Faculty of Health, University of Canberra, Canberra ACT 2601 (Australia); Taylor, Alan [Department of Psychology, Macquarie University, Sydney NSW 2109 (Australia)

    2013-10-15

    Background: As part of the only national survey of lead in Australian children, which was undertaken in 1996, lead isotopic and lead concentration measurements were obtained from children from 24 dwellings whose blood lead levels were ≥15 µg/dL in an attempt to determine the source(s) of their elevated blood lead. Comparisons were made with data for six children with lower blood lead levels (<10 µg/dL). Methods: Thermal ionisation and isotope dilution mass spectrometry were used to determine high precision lead isotopic ratios ({sup 208}Pb/{sup 206}Pb, {sup 207}Pb/{sup 206}Pb and {sup 206}Pb/{sup 204}Pb) and lead concentrations in blood, dust from floor wipes, soil, drinking water and paint (where available). Evaluation of associations between blood and the environmental samples was based on the analysis of individual cases, and Pearson correlations and multiple regression analyses based on the whole dataset. Results and discussion: The correlations showed an association for isotopic ratios in blood and wipes (r=0.52, 95% CI 0.19–0.74), blood and soil (r=0.33, 95% CI −0.05–0.62), and blood and paint (r=0.56, 95% CI 0.09–0.83). The regression analyses indicated that the only statistically significant relationship for blood isotopic ratios was with dust wipes (B=0.65, 95% CI 0.35–0.95); there were no significant associations for lead concentrations in blood and environmental samples. There is a strong isotopic correlation of soils and house dust (r=0.53, 95% CI 0.20–0.75) indicative of a common source(s) for lead in soil and house dust. In contrast, as with the regression analyses, no such association is present for bulk lead concentrations (r=−0.003, 95% CI −0.37–0.36), the most common approach employed in source investigations. In evaluation of the isotopic results on a case by case basis, the strongest associations were for dust wipes and blood. -- Highlights: • Children with elevated blood lead ≥15 µg/dL compared with a group with <10

  11. Surface dust wipes are the best predictors of blood leads in young children with elevated blood lead levels

    International Nuclear Information System (INIS)

    Gulson, Brian; Anderson, Phil; Taylor, Alan

    2013-01-01

    Background: As part of the only national survey of lead in Australian children, which was undertaken in 1996, lead isotopic and lead concentration measurements were obtained from children from 24 dwellings whose blood lead levels were ≥15 µg/dL in an attempt to determine the source(s) of their elevated blood lead. Comparisons were made with data for six children with lower blood lead levels ( 208 Pb/ 206 Pb, 207 Pb/ 206 Pb and 206 Pb/ 204 Pb) and lead concentrations in blood, dust from floor wipes, soil, drinking water and paint (where available). Evaluation of associations between blood and the environmental samples was based on the analysis of individual cases, and Pearson correlations and multiple regression analyses based on the whole dataset. Results and discussion: The correlations showed an association for isotopic ratios in blood and wipes (r=0.52, 95% CI 0.19–0.74), blood and soil (r=0.33, 95% CI −0.05–0.62), and blood and paint (r=0.56, 95% CI 0.09–0.83). The regression analyses indicated that the only statistically significant relationship for blood isotopic ratios was with dust wipes (B=0.65, 95% CI 0.35–0.95); there were no significant associations for lead concentrations in blood and environmental samples. There is a strong isotopic correlation of soils and house dust (r=0.53, 95% CI 0.20–0.75) indicative of a common source(s) for lead in soil and house dust. In contrast, as with the regression analyses, no such association is present for bulk lead concentrations (r=−0.003, 95% CI −0.37–0.36), the most common approach employed in source investigations. In evaluation of the isotopic results on a case by case basis, the strongest associations were for dust wipes and blood. -- Highlights: • Children with elevated blood lead ≥15 µg/dL compared with a group with <10 µg/dL. • High precision lead isotopic ratios in blood, house dust wipes, soil, water, paint. • Associations for isotopic measures of blood and dust, blood and

  12. Drivers of contaminant levels in surface water of China during 2000-2030: Relative importance for illustrative home and personal care product chemicals.

    Science.gov (United States)

    Zhu, Ying; Price, Oliver R; Kilgallon, John; Qi, Yi; Tao, Shu; Jones, Kevin C; Sweetman, Andrew J

    2018-03-21

    Water pollution are among the most critical problems in China and emerging contaminants in surface water have attracted rising attentions in recent years. There is great interest in China's future environmental quality as the national government has committed to a major action plan to improve surface water quality. This study presents methodologies to rank the importance of socioeconomic and environmental drivers to the chemical concentration in surface water during 2000-2030. A case study is conducted on triclosan, a home and personal care product (HPCP) ingredient. Different economic and discharge flow scenarios are considered. Urbanization and wastewater treatment connection rates in rural and urban areas are collected or projected for 2000-2030 for counties across China. The estimated usage increases from ca. 86 to 340 t. However, emissions decreases from 76 to 52 t during 2000-2030 under a modelled Organisation for Economic Co-operation (OECD) economic scenario because of the urbanization, migration and development of wastewater treatment plants/facilities (WWTPs). The estimated national median concentration of triclosan ranges 1.5-8.2 ng/L during 2000-2030 for different scenarios. It peaks in 2009 under the OECD and three of the Intergovernmental Panel on Climate Change (IPCC), A2, B1 and B2 economic scenarios, but in 2025 under A1 economic scenario. Population distribution and surface water discharge flow rates are ranked as the top two drivers to triclosan levels in surface water over the 30 years. The development of urban WWTPs was the most important driver during 2000-2010 and the development of rural works is projected to be the most important in 2011-2030. Projections suggest discharges of ingredients in HPCPs - controlled by economic growth - should be balanced by the major expenditure programme on wastewater treatment in China. Copyright © 2018 Elsevier Ltd. All rights reserved.

  13. A comparative study of reinitialization approaches of the level set method for simulating free-surface flows

    Energy Technology Data Exchange (ETDEWEB)

    Sufyan, Muhammad; Ngo, Long Cu; Choi, Hyoung Gwon [Seoul National University, Seoul (Korea, Republic of)

    2016-04-15

    Unstructured grids were used to compare the performance of a direct reinitialization scheme with those of two reinitialization approaches based on the solution of a hyperbolic Partial differential equation (PDE). The problems of moving interface were solved in the context of a finite element method. A least-square weighted residual method was used to discretize the advection equation of the level set method. The benchmark problems of rotating Zalesak's disk, time-reversed single vortex, and two-dimensional sloshing were examined. Numerical results showed that the direct reinitialization scheme performed better than the PDE-based reinitialization approaches in terms of mass conservation, dissipation and dispersion error, and computational time. In the case of sloshing, numerical results were found to be in good agreement with existing experimental data. The direct reinitialization approach consumed considerably less CPU time than the PDE-based simulations for 20 time periods of sloshing. This approach was stable, accurate, and efficient for all the problems considered in this study.

  14. French experience in design and construction of near-surface disposal facilities for low-level waste

    International Nuclear Information System (INIS)

    Jousselin, D.; Medal, G.; Augustin, X.; Wavrechin, B. de

    1993-01-01

    France disposes of all radioactive waste produced on its territory. Short-lived waste (with a half-life shorter than 30 years) are disposed of, since 1969 on the 'La Manche' disposal facility (CSM 'Centre de La Manche'). As this center will be saturated in 1994, ANDRA (French National Agency for Radioactive Waste Management) has undertaken in 1984 the studies and works necessary to the realization of a new disposal facility. TECHNICATOME was associated, since the beginning of those studies and was chosen by ANDRA as Prime Contractor for the new Radwaste Disposal Center. French conception was chosen by Spanish Authorities in 1987, ENRESA (Empresa Nacional de Residuos Radioactivos SA) selected the Cabril Site in the South of Spain as disposal of low and medium activity radwaste. TECHNICATOME was associated with this project, through a joint French-Spanish engineering team. Authority of North Carolina State (USA) decided in 1989 to build a low-level radioactive waste disposal facility and the contract has been awarded to CNSI (Chem Nuclear System Inc.) with a proposal based on the French experience. A french team ANDRA/TECHNICATOME/SGN is in charge of the design of the disposal facility

  15. Contemporary Surface Seasonal Oscillation and Vertical Deformation in Tibetan Plateau and Nepal Derived from the GPS, Leveling and GRACE Data

    Science.gov (United States)

    Shen, W.; Pan, Y.; Hwang, C.; Ding, H.

    2015-12-01

    We use 168 Continuous Global Positioning System (CGPS) stations distributed in the Tibetan Plateau (TP) and Nepal from lengths of 2.5 to 14 years to estimate the present-day velocity field in this area, including the horizontal and vertical deformations under the frame ITRF2008. We estimate and remove common mode errors in regional GPS time series using the principal component analysis (PCA), obtaining a time series with high signal to noise ratio. Following the maximum estimation analysis, a power law plus white noise stochastic model are adopted to estimate the velocity field. The highlight of Tibetan region is the crust vertical deformation. GPS vertical time series present seasonal oscillations caused by temporal mass loads, hence GRACE data from CSR are used to study the mass loads change. After removing the mass load deformations from GPS vertical rates, the results are improved. Leveling data about 48 years in this region are also used to estimate the rates of vertical movements. Our study suggests that the boundary of south Nepal is still sinking due to the fact that the India plate is crashing into the Eurasian plate. The uplift rates from south to north of TP reduce gradually. Himalayas region and north Nepal uplift around 6 mm/yr in average. The uplift rate along East TP in Qinhai is around 2.7 mm/yr in average. In contrast, the southeast of Tibetan Plateau, south Yunnan and Tarim in Xinjiang sink with different magnitudes. Our observation results suggest complicated mechanism of the mass migration in TP. This study is supported by National 973 Project China (grant Nos. 2013CB733302 and 2013CB733305), NSFC (grant Nos. 41174011, 41429401, 41210006, 41128003, 41021061).

  16. Alkaline Plume in the Aptian Sand Aquifer in the Context of Low-Level Radioactive Waste Surface Disposal

    Science.gov (United States)

    Cochepin, B.; Munier, I.; MADE, B.

    2017-12-01

    The storage vaults for low and intermediate-level short-lived radioactive waste in the East of France are settled on the Aptian sand layer. In the context of the periodic examination by the nuclear regulators, it has been recommended to assess more precisely the chemical conditions for a potential release of radionuclides in the underlying water table. In particular, this study aims at assessing the eventuality of spreading an alkaline plume in the Aptian sand pore water by the chemical degradation of the vault cementitious materials. The numerical approach developed for this purpose is supported by both experimental characterizations of tracers in the water table and results from preliminary numerical studies on the hydrology of the site and the hydraulic evolution of the storage. The results from these specific simulations were simplified in the reactive transport model to focus on the mechanistic description of the chemical processes taking place in the waste and vaults and on their consequences on the underlying water table. During the operating period of the disposal, the reactive transport modelling shows that the low water saturation in the vaults material and in the vadose zone prevents the aquifer from a significant increase of the water pH under the cement-based vaults. These results are in reasonable agreement with the pH regularly measured in the underlying water table. After storage closure, during the few hundred years of the monitoring period and furthermore beyond, the reactive transport modelling shows a noticeable release of hydroxyls and alkali ions under the disposal vaults and their spread downstream the storage site leading to pH values above 10. It is noteworthy that the pH is not buffered in the Aptian sands because of their low amount in clayey minerals. This effect is now considered for pH-sensitive radionuclide solutes in safety assessment calculations by weighting correspondingly their retention parameters.

  17. Distribution and levels of cell surface expression of CD33 and CD123 in acute myeloid leukemia

    Science.gov (United States)

    Ehninger, A; Kramer, M; Röllig, C; Thiede, C; Bornhäuser, M; von Bonin, M; Wermke, M; Feldmann, A; Bachmann, M; Ehninger, G; Oelschlägel, U

    2014-01-01

    Owing to the more recent positive results with the anti-CD33 immunotoxin gemtuzumab ozogamicin, therapy against acute myeloid leukemias (AMLs) targeting CD33 holds many promises. Here, CD33 and CD123 expression on AML blasts was studied by flow cytometry in a cohort of 319 patients with detailed information on French–American–British/World Health Organization (FAB/WHO) classification, cytogenetics and molecular aberrations. AMLs of 87.8% express CD33 and would therefore be targetable with anti-CD33 therapies. Additionally, 9.4% of AMLs express CD123 without concomitant CD33 expression. Thus, nearly all AMLs could be either targeted via CD33 or CD123. Simultaneous presence of both antigens was observed in 69.5% of patients. Most importantly, even AMLs with adverse cytogenetics express CD33 and CD123 levels comparable to those with favorable and intermediate subtypes. Some patient groups with unfavorable alterations, such as FMS-related tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutations, high FLT3-ITD mutant/wild-type ratios and monosomy 5 are even characterized by high expression of CD33 and CD123. In addition, blasts of patients with mutant nucleophosmin (NPM1) revealed significantly higher CD33 and CD123 expression pointing toward the possibility of minimal residual disease-guided interventions in mutated NPM1-positive AMLs. These results stimulate the development of novel concepts to redirect immune effector cells toward CD33- and CD123-expressing blasts using bi-specific antibodies or engineered T cells expressing chimeric antigen receptors. PMID:24927407

  18. Polybrominated Diphenyl Ethers (PBDEs) in Surface Soils across Five Asian Countries: Levels, Spatial Distribution, and Source Contribution.

    Science.gov (United States)

    Li, Wen-Long; Ma, Wan-Li; Jia, Hong-Liang; Hong, Wen-Jun; Moon, Hyo-Bang; Nakata, Haruhiko; Minh, Nguyen Hung; Sinha, Ravindra Kumar; Chi, Kai Hsien; Kannan, Kurunthachalam; Sverko, Ed; Li, Yi-Fan

    2016-12-06

    A total of 23 polybrominated diphenyl ether (PBDE) congeners were measured in soil samples collected in areas with no known point source [urban/rural/background (U/R/B) sites] and in areas with known point source [brominated flame retardant (BFR)-related industrial sites (F sites) and e-waste recycling sites (E sites)] across five Asian countries. The highest PBDE concentrations were found in BFR-related industrial and e-waste recycling sites. The concentrations of PBDEs in U/R/B sites decreased in the following order: urban > rural > background sites. Total PBDE concentrations were dominated by BDE-209, while BDE-17, -85, -138, -191, -204, and -205 were the least abundant compounds. In both urban sites and rural sites, the mean concentrations of total PBDEs (∑ 23 BDEs) in soils decreased in the following order: Japan > China > South Korea > India > Vietnam. The concentrations of PBDEs in soils were comparable with those reported in other studies. Among the three commercial PBDE mixtures, relatively large contributions of commercial penta-BDE were observed in Vietnam, whereas deca-BDE was the dominant form in mixtures contributing from 55.8 ± 2.5 to 100.0 ± 1.2% of the total PBDEs in soils collected from other four countries. Regression analysis suggested that local population density (PD) is a good indicator of PBDEs in soils of each country. Significant and positive correlation between soil organic content and PBDE level was observed in Chinese soil for most nondeca-BDE homologues with their usage stopped 10 years ago, indicating its important role in controlling the revolatilization of PBDEs from soil and changing the spatial trend of PBDE in soil from the primary distribution pattern to the secondary distribution pattern, especially when primary emission is ceased.

  19. Relations between total phosphorus and orthophosphorus concentrations and rainfall, surface-water discharge, and groundwater levels in Big Cypress Seminole Indian Reservation, Florida, 2014–16

    Science.gov (United States)

    McBride, W. Scott; Sifuentes, Dorothy F.

    2018-02-06

    nearby sites during the same period. Differences in concentrations can likely be explained by differences in sample collection methods, sampling locations, sample collection time, and the hydrology during sampling or by the number of samples collected. A major limitation of this study was the short duration of sample collection, which covers a limited range of hydrologic conditions within the BCSIR.The effect of surface-water and groundwater hydrologic conditions on TP and OP concentrations was assessed by using rainfall data and surface-water stage and discharge records. The highest TP and OP concentrations occurred during peak surface-water flows in the canals following long dry periods. Concentrations of TP and OP increased internal to the BCSIR in the western half of the BCSIR during wet periods, but increased concentrations tended to lag behind rainfall events, likely because control structures upstream of sampling sites do not release flows until the water levels in the canals reach predetermined levels. This pattern may indicate that bed sediments in the canals contain high concentrations of phosphorus that becomes resuspended during high flows or that phosphorus salts that had accumulated on dry land during dry periods are carried into the canals by runoff. The largest TP spikes usually occurred at the beginning of high-flow events, but then quickly tapered off even when flows remained high.Groundwater flows were assessed in the BCSIR by using groundwater level observations from two preexisting USGS monitoring well clusters, each characterized by a shallow well installed in the surficial aquifer system and a deeper well installed in the intermediate aquifer system. Groundwater levels were evaluated with respect to surface-water levels and discharge in the BCSIR during the period of surface-water sampling. During dry conditions water levels in canals were often higher than groundwater levels in the surficial aquifer, indicating the potential for surface water to

  20. Correlations of cave levels, stream terraces and planation surfaces along the River Mur-Timing of landscape evolution along the eastern margin of the Alps.

    Science.gov (United States)

    Wagner, Thomas; Fritz, Harald; Stüwe, Kurt; Nestroy, Othmar; Rodnight, Helena; Hellstrom, John; Benischke, Ralf

    2011-11-01

    The transition zone of the Eastern Alps to the Pannonian Basin provides one of the best sources of information on landscape evolution of the Eastern Alpine mountain range. The region was non-glaciated during the entire Pleistocene. Thus, direct influence of glacial carving as a landscape forming process can be excluded and relics of landforms are preserved that date back to at least the Late Neogene. In this study, we provide a correlation between various planation surfaces across the orogen-basin transition. In particular, we use stream terraces, planation surfaces and cave levels that cover a vertical spread of some 700 m. Our correlation is used to show that both sides of the transition zone uplifted together starting at least about 5 Ma ago. For our correlation we use recently published terrestrial cosmogenic nuclide (TCN) burial ages from cave sediments, new optically stimulated luminescence (OSL) ages of a stream terrace and U-Th ages from speleothems. Minimum age constraints of cave levels from burial ages of cave sediments covering the last ~ 4 Ma are used to place age constraints on surface features by parallelizing cave levels with planation surfaces. The OSL results for the top section of the type locality of the Helfbrunn terrace suggest an Early Würm development (80.5 ± 3.7 to 68.7 ± 4.0 ka). The terrace origin as a penultimate gravel deposit (in classical Alpine terminology Riss) is therefore questioned. U-series speleothem ages from caves nearby indicate formation during Marine Isotope Stages (MIS) 5c and 5a which are both interstadial warm periods. As OSL ages from the terrace also show a time of deposition during MIS 5a ending at the MIS 5/4 transition, this supports the idea of temperate climatic conditions at the time of deposition. In general, tectonic activity is interpreted to be the main driving force for the formation and evolution of these landforms, whilst climate change is suggested to be of minor importance. Obvious hiatuses

  1. Impact of the 2008 Global Recession on air quality over the United States: Implications for surface ozone levels from changes in NOx emissions

    Science.gov (United States)

    Tong, Daniel; Pan, Li; Chen, Weiwei; Lamsal, Lok; Lee, Pius; Tang, Youhua; Kim, Hyuncheol; Kondragunta, Shobha; Stajner, Ivanka

    2016-09-01

    Satellite and ground observations detected large variability in nitrogen oxides (NOx) during the 2008 economic recession, but the impact of the recession on air quality has not been quantified. This study combines observed NOx trends and a regional chemical transport model to quantify the impact of the recession on surface ozone (O3) levels over the continental United States. The impact is quantified by simulating O3 concentrations under two emission scenarios: business-as-usual (BAU) and recession. In the BAU case, the emission projection from the Cross-State Air Pollution Rule is used to estimate the "would-be" NOx emission level in 2011. In the recession case, the actual NO2 trends observed from Air Quality System ground monitors and the Ozone Monitoring Instrument on the Aura satellite are used to obtain "realistic" changes in NOx emissions. The model prediction with the recession effect agrees better with ground O3 observations over time and space than the prediction with the BAU emission. The results show that the recession caused a 1-2 ppbv decrease in surface O3 concentration over the eastern United States, a slight increase (0.5-1 ppbv) over the Rocky Mountain region, and mixed changes in the Pacific West. The gain in air quality benefits during the recession, however, could be quickly offset by the much slower emission reduction rate during the post-recession period.

  2. Impact of the 2008 Global Recession on Air Quality over the United States: Implications for Surface Ozone Levels from Changes in NOx Emissions

    Science.gov (United States)

    Tong, Daniel; Pan, Li; Chen, Weiwei; Lamsal, Lok; Lee, Pius; Tang, Youhua; Kim, Hyuncheol; Kondragunta, Shobha; Stajner, Ivanka

    2016-01-01

    Satellite and ground observations detected large variability in nitrogen oxides (NOx) during the 2008 economic recession, but the impact of the recession on air quality has not been quantified. This study combines observed NOx trends and a regional chemical transport model to quantify the impact of the recession on surface ozone (O3) levels over the continental United States. The impact is quantified by simulating O3 concentrations under two emission scenarios: business-as-usual (BAU) and recession. In the BAU case, the emission projection from the Cross-State Air Pollution Rule is used to estimate the would-be NOx emission level in 2011. In the recession case, the actual NO2 trends observed from Air Quality System ground monitors and the Ozone Monitoring Instrument on the Aura satellite are used to obtain realistic changes in NOx emissions. The model prediction with the recession effect agrees better with ground O3 observations over time and space than the prediction with the BAU emission. The results show that the recession caused a 12ppbv decrease in surface O3 concentration over the eastern United States, a slight increase (0.51ppbv) over the Rocky Mountain region, and mixed changes in the Pacific West. The gain in air quality benefits during the recession, however, could be quickly offset by the much slower emission reduction rate during the post-recession period.

  3. Relationship between interleukin 1α levels in the gingival crevicular fluid in health and in inflammatory periodontal disease and periodontal inflamed surface area: A correlative study.

    Science.gov (United States)

    Govindarajan, Kalaichelvi; Muthukumar, Santhanakrishnan; Rangarao, Suresh

    2015-01-01

    Periodontitis has been suggested as a source of inflammation for pathological changes in distant sites. Interleukin-1 alpha (IL-1α) has shown to have specific roles in inflammation, immunity, tissue breakdown, and tissue homeostasis. This study assessed the correlation of periodontal inflamed surface area (PISA) index with the gingival crevicular fluid (GCF) levels of IL-1α, which would be helpful in evaluating the validity of PISA index in terms of reflection of the disease. A total of 40 subjects were recruited for this study and 20 subjects with healthy gingiva (Group I) served as controls and 20 subjects served as cases with periodontitis (Group II). Samples of GCF were obtained from one site in each patient by placing color-coded, calibrated, volumetric microcapillary pipettes extracrevicularly, and subjected to ELISA test. There was a statistical significance for mean probing depth (PD) and periodontal epithelial surface area (PESA) (P periodontitis group correlating with higher IL-1α levels, which clearly indicates the validity of PISA index.

  4. Estimating the Greenland ice sheet surface mass balance contribution to future sea level rise using the regional atmospheric climate model MAR

    Directory of Open Access Journals (Sweden)

    X. Fettweis

    2013-03-01

    Full Text Available To estimate the sea level rise (SLR originating from changes in surface mass balance (SMB of the Greenland ice sheet (GrIS, we present 21st century climate projections obtained with the regional climate model MAR (Modèle Atmosphérique Régional, forced by output of three CMIP5 (Coupled Model Intercomparison Project Phase 5 general circulation models (GCMs. Our results indicate that in a warmer climate, mass gain from increased winter snowfall over the GrIS does not compensate mass loss through increased meltwater run-off in summer. Despite the large spread in the projected near-surface warming, all the MAR projections show similar non-linear increase of GrIS surface melt volume because no change is projected in the general atmospheric circulation over Greenland. By coarsely estimating the GrIS SMB changes from GCM output, we show that the uncertainty from the GCM-based forcing represents about half of the projected SMB changes. In 2100, the CMIP5 ensemble mean projects a GrIS SMB decrease equivalent to a mean SLR of +4 ± 2 cm and +9 ± 4 cm for the RCP (Representative Concentration Pathways 4.5 and RCP 8.5 scenarios respectively. These estimates do not consider the positive melt–elevation feedback, although sensitivity experiments using perturbed ice sheet topographies consistent with the projected SMB changes demonstrate that this is a significant feedback, and highlight the importance of coupling regional climate models to an ice sheet model. Such a coupling will allow the assessment of future response of both surface processes and ice-dynamic changes to rising temperatures, as well as their mutual feedbacks.

  5. Relationship between interleukin 1α levels in the gingival crevicular fluid in health and in inflammatory periodontal disease and periodontal inflamed surface area: A correlative study

    Directory of Open Access Journals (Sweden)

    Kalaichelvi Govindarajan

    2015-01-01

    Full Text Available Background: Periodontitis has been suggested as a source of inflammation for pathological changes in distant sites. Interleukin-1 alpha (IL-1α has shown to have specific roles in inflammation, immunity, tissue breakdown, and tissue homeostasis. This study assessed the correlation of periodontal inflamed surface area (PISA index with the gingival crevicular fluid (GCF levels of IL-1α, which would be helpful in evaluating the validity of PISA index in terms of reflection of the disease. Materials and Methods: A total of 40 subjects were recruited for this study and 20 subjects with healthy gingiva (Group I served as controls and 20 subjects served as cases with periodontitis (Group II. Samples of GCF were obtained from one site in each patient by placing color-coded, calibrated, volumetric microcapillary pipettes extracrevicularly, and subjected to ELISA test. Results: There was a statistical significance for mean probing depth (PD and periodontal epithelial surface area (PESA (P < 0.01, mean bleeding on probing and PISA, IL-1α (P < 0.01 and PESA (P < 0.05 in Group I. Statistical significance was found between PISA and IL-1α in Group I (P < 0.01. A positive correlation was found in Group II between mean PD and mean attachment loss (P < 0.01, PISA, IL-1α and PESA (P < 0.01, PISA and IL-1α levels (P < 0.01 which was statistically significant. Conclusion: The inflammatory burden index was statistically significant in the periodontitis group correlating with higher IL-1α levels, which clearly indicates the validity of PISA index.

  6. Effects of hypobaric Endurance Training on Graded Exercise Induced Lymphocyte Mobilization, Senescence and Their Surface Thiol Levels in Elite Male Athletes

    Directory of Open Access Journals (Sweden)

    Karim - Azali Alamdari

    2018-03-01

    Full Text Available The effects of each hypoxemic exercise session or overall training period still remains to be more elucidated in elite athletes. Therefore, we investigated the effects of hypobaric endurance training on lymphocytes mobilization and senescence and also their surface Thiol levels following to graded exercise test (GXT in elite male athletes. Fourty six volunteer subjects were randomized into normobaric control (NC, hypobaric control (HC, normobaric exercise (NE and hypobaric exercise (HE groups. The NE and HE groups were exposed to homeland (700 mmHg and 2800 meters above sea level (570 mmHg simulated barometric pressures respectively, while HC and NC groups were remained sedentary at the same conditions. The training was included on treadmill running for four weeks, five sessions/week, 45 min/ session. Each session was consisted of three-min warmed up period, three cycles of 10-min running at 65% maximal heart rate reserve (HRRmax interspersed with a three-min active recovery and three-min cool-down running period. Two GXTs were performed before (baseline and after the interventions and blood samples were collected three times at both occasions. In all groups, mobilization of CD8+lymphocytes and senescent phenotype population of their both CD4+ and CD8+ subsets were increased after both GXTs, however; these changes were reversed following to recovery period(P<0.05. Moreover, HE were decreased lymphocytes surface thiol levels before and after the second GXT (P<0.05.it can be concluded that HE has no additional benefits for elite athletes regarded to lymphocytes mobilization and senescence, however; it may render them to oxidative stress.  

  7. Levels and isomer profiles of Dechlorane Plus in the surface soils from e-waste recycling areas and industrial areas in South China

    Energy Technology Data Exchange (ETDEWEB)

    Yu Zhiqiang [State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environment and Resources, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640 (China); Lu Shaoyou; Gao Shutao; Wang Jingzhi [State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environment and Resources, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640 (China); Graduate School of the Chinese Academy of Sciences, Beijing 100039 (China); Li Huiru, E-mail: huiruli@gig.ac.c [State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environment and Resources, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640 (China); Zeng Xiangying; Sheng Guoying; Fu Jiamo [State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environment and Resources, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640 (China)

    2010-09-15

    Dechlorane Plus (DP) is a highly chlorinated flame retardant. Levels of DP were measured in surface soils from e-waste recycling areas and industrial areas in South China. Higher DP levels were found in e-waste recycling areas (undetectable-47.4 ng/g) than those in industrial areas (0.0336-4.65 ng/g) in South China. The highest DP concentration (3327 ng/g) was found at the e-waste recycling site in Qingyuan, while DP levels fell dramatically with increasing distance away from the recycling site, suggesting that the e-waste recycling activities are an important source of DP emissions. The mean ratios of anti-DP to total DP (f{sub anti}) for different sampling areas ranged from 0.58 to 0.76 and showed no significant difference from the ratio for the technical DP products (t-test, p > 0.05). Further intensive studies are needed to investigate the process of DP degradation and its degradation products. - High DP concentrations were found in the soils from e-waste recycling regions, and e-waste recycling was the major source of DP emissions in South China.

  8. Durability test of geomembrane liners presumed to avail near surface disposal facilities for low-level waste generated from research, industrial and medical facilities

    International Nuclear Information System (INIS)

    Nakata, Hisakazu; Amazawa, Hiroya; Sakai, Akihiro; Kurosawa, Ryohei; Sakamoto, Yoshiaki; Kanno, Naohiro; Kashima, Takahiro

    2014-02-01

    The Low-level Radioactive Waste Disposal Project Center will construct near surface disposal facilities for radioactive wastes from research, industrial and medical facilities. The disposal facilities consist of “concrete pit type” for low-level radioactive wastes and “trench type” for very low level radioactive wastes. As for the trench type disposal facility, two kinds of facility designs are on projects – one for a normal trench type disposal facility without any of engineered barriers and the other for a trench type disposal facility with geomembrane liners that could prevent from causing environmental effects of non radioactive toxic materials contained in the waste packages. The disposal facility should be designed taking basic properties of durability on geomembrane liners into account, for it is exposed to natural environment on a long-term basis. This study examined mechanical strength and permeability properties to assess the durability on the basis of an indoor accelerated exposure experiment targeting the liner materials presumed to avail the conceptual design so far. Its results will be used for the basic and detailed design henceforth by confirming the empirical degradation characteristic with the progress of the exposure time. (author)

  9. Novel application of satellite and in-situ measurements to map surface-level NO2 in the Great Lakes region

    Directory of Open Access Journals (Sweden)

    C. Mihele

    2011-11-01

    Full Text Available Ozone Monitoring Instrument (OMI tropospheric NO2 vertical column density data were used in conjunction with in-situ NO2 concentrations collected by permanently installed monitoring stations to infer 24 h surface-level NO2 concentrations at 0.1° (~11 km resolution. The region examined included rural and suburban areas, and the highly industrialised area of Windsor, Ontario, which is situated directly across the US-Canada border from Detroit, MI. Photolytic NO2 monitors were collocated with standard NO2 monitors to provide qualitative data regarding NOz interference during the campaign. The accuracy of the OMI-inferred concentrations was tested using two-week integrative NO2 measurements collected with passive monitors at 18 locations, approximating a 15 km grid across the region, for 7 consecutive two-week periods. When compared with these passive results, satellite-inferred concentrations showed an 18% positive bias. The correlation of the passive monitor and OMI-inferred concentrations (R=0.69, n=115 was stronger than that for the passive monitor concentrations and OMI column densities (R=0.52, indicating that using a sparse network of monitoring sites to estimate concentrations improves the direct utility of the OMI observations. OMI-inferred concentrations were then calculated for four years to show an overall declining trend in surface NO2 concentrations in the region. Additionally, by separating OMI-inferred surface concentrations by wind direction, clear patterns in emissions and affected down-wind regions, in particular around the US-Canada border, were revealed.

  10. Summertime state-level source-receptor relationships between nitrogen oxides emissions and surface ozone concentrations over the continental United States.

    Science.gov (United States)

    Tong, Daniel Q; Mauzerall, Denise L

    2008-11-01

    Interstate transport of ozone (O3) and its precursors can contribute substantially to state-level surface o3 concentrations, making it difficult for some states to meet the National Ambient Air Quality Standards (NAAQS) for O3 by limiting only their own emissions. We analyze the effect of interstate transport on surface O3 in each continental U.S. state in July 1996 using the community multiscale air quality (CMAQ) model. By examining the difference between a baseline simulation and perturbation simulations in which each state's nitrogen oxides (NOx) emissions are removed, we establish for the first time a summertime source-receptor matrix for all 48 continental states. We find that for 16 (20) states at least one neighboring state's NOx emissions are responsible for a larger increase in monthly mean peak 8 h (all-hour) O3 concentrations than the state's own emissions. For over 80% of the contiguous states, interstate transport is more importantthan local emissions for summertime peak O3 concentrations. Our source-receptor matrices indicate that the geographic range of the clean air interstate rule (CAIR) was sufficient to address interstate transport of O3 in most of the states included in the program. However, the exclusion of Texas, which has particularly large NOx emissions, from the CAIR O3 program left emission sources uncontrolled that contribute more than 1 ppbv to the July mean of peak 8 h O3 concentrations in over a dozen states.

  11. Spatio-Temporal Variability of Dissolved Metals in the Surface Waters of an Agroforestry Catchment with Low Levels of Anthropogenic Activity

    Science.gov (United States)

    Soto-Varela, Fátima; Rodríguez-Blanco, M. Luz; Mercedes Taboada-Castro, M.; Taboada-Castro, M. Teresa

    2017-12-01

    Evaluation of levels and spatial variations of metals in surface waters within a catchment are critical to understanding the extent of land-use impact on the river system. The aims of this study were to investigate the spatial and temporal variations of five dissolved metals (Al, Fe, Mn, Cu and Zn) in surface waters of a small agroforestry catchment (16 km2) in NW Spain. The land uses include mainly forests (65%) and agriculture (pastures: 26%, cultivation: 4%). Stream water samples were collected at four sampling sites distributed along the main course of the Corbeira stream (Galicia, NW Spain) between the headwaters and the catchment outlet. The headwater point can be considered as pristine environment with natural metal concentrations in waters because of the absence of any agricultural activity and limited accessibility. Metal concentrations were determined by ICP-MS. The results showed that metal concentrations were relatively low (Fe > Al > Mn > Zn > Cu), suggesting little influence from agricultural activities in the area. Mn and Zn did not show significant differences between sampling points along main stream, while for Fe and Cu significant differences were found between the headwaters and all other points. Al tended to decrease from the headwaters to the catchment outlet.

  12. A novel multi-level IC-compatible surface microfabrication technology for MEMS with independently controlled lateral and vertical submicron transduction gaps

    Science.gov (United States)

    Cicek, Paul-Vahe; Elsayed, Mohannad; Nabki, Frederic; El-Gamal, Mourad

    2017-11-01

    An above-IC compatible multi-level MEMS surface microfabrication technology based on a silicon carbide structural layer is presented. The fabrication process flow provides optimal electrostatic transduction by allowing the creation of independently controlled submicron vertical and lateral gaps without the need for high resolution lithography. Adopting silicon carbide as the structural material, the technology ensures material, chemical and thermal compatibility with modern semiconductor nodes, reporting the lowest peak processing temperature (i.e. 200 °C) of all comparable works. This makes this process ideally suited for integrating capacitive-based MEMS directly above standard CMOS substrates. Process flow design and optimization are presented in the context of bulk-mode disk resonators, devices that are shown to exhibit improved performance with respect to previous generation flexural beam resonators, and that represent relatively complex MEMS structures. The impact of impending improvements to the fabrication technology is discussed.

  13. Using Nano-mechanics and Surface Acoustic Wave (SAW) for Disease Monitoring and Diagnostics at a Cellular Level in Red Blood Cells

    Science.gov (United States)

    Sivanantha, Ninnuja; Ma, Charles; Collins, David J.; Sesen, Muhsincan; Brenker, Jason; Coppel, Ross L.; Neild, Adrian; Alan, Tuncay

    A popular approach to monitoring diseases and their diagnosis is through biological, pathological or immunological characterization. However, at a cellular level progression of certain diseases manifests itself through mechanical effects as well. Here, we present a method which exploits localised flow; surface acoustic wave (SAW) induced acoustic streaming in a 9 μL droplet to characterize the adhesive properties of red blood cells (healthy, gluteraldehyde treated and malaria infected) in approximately 50 seconds. Our results show a 79% difference in cell mobilization between healthy malaria infected RBCs (and a 39% difference between healthy and treated ones), indicating that the method can serve as a platform for rapid clinical diagnosis; where separation of two or more different cell populations in a mixed solution is desirable. It can also act as a key biomarker for monitoring some diseases offering quantitative measures of disease progression and response to therapy.

  14. Cosmic-muon intensity measurement and overburden estimation in a building at surface level and in an underground facility using two BC408 scintillation detectors coincidence counting system.

    Science.gov (United States)

    Zhang, Weihua; Ungar, Kurt; Liu, Chuanlei; Mailhot, Maverick

    2016-10-01

    A series of measurements have been recently conducted to determine the cosmic-muon intensities and attenuation factors at various indoor and underground locations for a gamma spectrometer. For this purpose, a digital coincidence spectrometer was developed by using two BC408 plastic scintillation detectors and an XIA LLC Digital Gamma Finder (DGF)/Pixie-4 software and card package. The results indicate that the overburden in the building at surface level absorbs a large part of cosmic ray protons while attenuating the cosmic-muon intensity by 20-50%. The underground facility has the largest overburden of 39 m water equivalent, where the cosmic-muon intensity is reduced by a factor of 6. The study provides a cosmic-muon intensity measurement and overburden assessment, which are important parameters for analysing the background of an HPGe counting system, or for comparing the background of similar systems. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. ANDRA's Centre de l'Aube: Design, construction, operation of a state of the art surface disposal facility for low and intermediate level waste

    International Nuclear Information System (INIS)

    Potier, J.M.

    2001-01-01

    The ANDRA's Centre de I'Aube disposal facility for low and intermediate level radioactive waste may be considered as a state-of-the-art repository. Since its implementation in the early nineties, the French facility has been used as a model by many countries worldwide for the surface disposal of radioactive waste. The disposal concept developed by ANDRA, the French Radioactive Waste Management Agency, consists of a multiple-barrier system designed to isolate radioactivity and provide protection to the public and to the environment. Waste operations at ANDRA's Centre de I'Aube are largely automated to ensure better protection to site workers. The paper reviews all aspects of the repository implementation: siting, design, construction, operation and future closure, and environmental monitoring. (author)

  16. Impact and Suggestion of Column-to-Surface Vertical Correction Scheme on the Relationship between Satellite AOD and Ground-Level PM2.5 in China

    Directory of Open Access Journals (Sweden)

    Wei Gong

    2017-10-01

    Full Text Available As China is suffering from severe fine particle pollution from dense industrialization and urbanization, satellite-derived aerosol optical depth (AOD has been widely used for estimating particulate matter with an aerodynamic diameter less than 2.5 μm (PM2.5. However, the correlation between satellite AOD and ground-level PM2.5 could be influenced by aerosol vertical distribution, as satellite AOD represents the entire column, rather than just ground-level concentration. Here, a new column-to-surface vertical correction scheme is proposed to improve separation of the near-surface and elevated aerosol layers, based on the ratio of the integrated extinction coefficient within 200–500 m above ground level (AGL, using the Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP aerosol profile products. There are distinct differences in climate, meteorology, terrain, and aerosol transmission throughout China, so comparisons between vertical correction via CALIOP ratio and planetary boundary layer height (PBLH were conducted in different regions from 2014 to 2015, combined with the original Pearson coefficient between satellite AOD and ground-level PM2.5 for reference. Furthermore, the best vertical correction scheme was suggested for different regions to achieve optimal correlation with PM2.5, based on the analysis and discussion of regional and seasonal characteristics of aerosol vertical distribution. According to our results and discussions, vertical correction via PBLH is recommended in northwestern China, where the PBLH varies dramatically, stretching or compressing the surface aerosol layer; vertical correction via the CALIOP ratio is recommended in northeastern China, southwestern China, Central China (excluding summer, North China Plain (excluding Beijing, and the spring in the southeast coast, areas that are susceptible to exogenous aerosols and exhibit the elevated aerosol layer; and original AOD without vertical correction is

  17. Influence of nonuniformity of the submerged perforated sheet on steam demand leveling on the evaporation surface of a VVER steam generator

    Science.gov (United States)

    Blinkov, V. N.; Elkin, I. V.; Emelianov, D. A.; Melikhov, V. I.; Melikhov, O. I.; Nerovnov, A. A.; Nikonov, S. M.; Parfenov, Y. V.

    2016-01-01

    The results of a calculation and experimental research of the influence of nonuniformity of the submerged perforated sheet on steam demand leveling on the evaporation surface are published in the current article. A short description of the PGV test facility and a measuring system whose test section is a transverse "cut" of an actual PGV-1000 steam generator with the internals is presented. The methods of experimental starts are explained and instrumentations are described. A uniformly perforated sheet with the flow section of 5.7% and a nonuniformly perforated sheet with the flow section of 4.3% on the cold half and 8.1% on the hot half were used in the experiments. The system pressure was approximately 7 MPa, the inlet steam flow rate was varied between 4.23 and 7.94 t/h, i.e., the steam velocity on the evaporation surface was 0.15-0.29 m/s. The experimental results were analyzed with (1) the engineering method based on estimating the flow rates of steam on hot and cold half by the experimental values of the pressure drop on submerged list and (2) the STEG code, which was developed for three-dimensional mathematical modeling of the two-phase thermohydraulics in the heat exchanger volume and upgraded. It was established that changing the perforation from a uniform to a nonuniform one increases the residual nonuniformity coefficient, which characterizes the flow of steam from the hot side to the cold side under the sheet. However, the steam separation becomes worse because of a high local residual nonuniformity coefficients near the border of two plates with different perforation levels.

  18. Effect of low-level CO2 laser radiation on the inhibition of smooth-surface caries (in-vitro study)

    Science.gov (United States)

    Boran, Thomas L.; Zakariasen, Kenneth L.

    1990-06-01

    The application of lasers in dentistry is not a new concept. Lasers have been used in various areas of dental research over the last two decades. However, recent technological development and research findings indicate that widespread clinical application of lasers will occur shortly. Many of the early studies discovered that high levels of laser radiation were detrimental to the vitality of the dental pulp. This has led researchers to investigate whether low level laser radiation would have positive effects on the various components of the dental hard tissues. This study examined the anti-carious effect of low level C02 laser radiation on smooth surface enamel. Fifty extracted third molars were selected and covered in acid resistant varnish except for two windows on the buccal surface just above the CEJ. The windows measured 1.5 x 1.5 mm with one window designated as the control and the other experimental. In each experiment the Pfizer Model 10-C laser system was used. The teeth were divided into two groups. In group I, the experimental window was lased with 1.2 watts at 0.1 seconds with a 1.5 mm focal spot. In Group II, the experimental window was lased with 2.4 watts at 0. 1 seconds with a 1.5 mm focal spot. Both groups were exposed for 12 days in a demineralizing solution (2.2 mM Ca, 2.2 mM P0 ,50 mM acetic acid, 5 ppmF-@ constant pH -4.3). The resulting lesions were sectioned to approximately 80 im thickness using a hard tissue microtome. Each section was examined by taking polarized light photomicrographs after imbibition in H20 medium. Results of the study suggested a significant reduction in the lesion size in both experiments, all exposures being within the biological safe zone of temperature elevation to the surrounding vital tissues, e.g. the dental pulp and periodontal tissue. Further research will be required to determine the level of CO2 laser radiation which will provide the maximum anti-carious effect.

  19. Correlation between E. coli levels and the presence of foodborne pathogens in surface irrigation water: Establishment of a sampling program.

    Science.gov (United States)

    Truchado, Pilar; Hernandez, Natalia; Gil, Maria I; Ivanek, Renata; Allende, Ana

    2018-01-01

    To establish the association between microbial indicators and the presence of foodborne pathogens in irrigation water, Escherichia coli was enumerated using two quantification methods (plate counts and PMA-qPCR) and presence/absence of pathogenic microorganisms, including five strains from the Shiga toxigenic E. coli (O157:H7, O26, O103, O111 and O145) and Salmonella spp. were evaluated. The results confirmed that surface water can be considered a microbial hazard when used for irrigation. The levels of viable E. coli were very similar to those of cultivable E. coli, except for irrigation water obtained from water reservoirs. Comparison between the E. coli counts in samples positive and negative for the presence of pathogenic bacteria for the evaluated water sources identified E. coli level of 2.35 log cfu/100 mL as a cut-off able to correctly predict positive and negative samples with 93% sensitivity and 66% specificity, respectively. Thus, for the samples with levels of E. coli under 2.35 log cfu/100 mL (e.g., 2.24 log cfu/100 mL) there was a 90% probability that the samples were not contaminated with pathogenic microorganism in locations with similar prevalence. E. coli levels in irrigation water were affected by the ambient temperature confirming that water source and climate conditions should be taken into account by growers when designing a sampling program and the frequency of the monitoring to make a better and more efficient use of their resources. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Impact of high-level sport practice on anal incontinence in a healthy young female population.

    Science.gov (United States)

    Vitton, Véronique; Baumstarck-Barrau, Karine; Brardjanian, Sarah; Caballe, Isabelle; Bouvier, Michel; Grimaud, Jean-Charles

    2011-05-01

    Regular physical activity usually confers health benefits, but high-level sport may induce harmful outcomes, such as pelvic floor dysfunction. Urinary incontinence (UI) was previously documented, but few data are available about anal incontinence (AI) in female athletes. Our aim was to determine the role of high-level sport practice on AI in a young, healthy female population. In this cross-sectional study, we included women aged 18-40 years. Self-administered questionnaires were delivered to each female volunteer. Two groups were defined: (1) intensive sport (IS) group: high-level sport (>8 hours weekly), and (2) nonintensive sport (NIS) group: all other subjects. Of the 393 women enrolled, 169 were in the IS group and 224 were in the NIS group. Women of the IS group were significantly younger than the others (21.74±4.28 vs. 24.87±5.61 years, pAI was statistically higher in the IS group than in the NIS group (14.8% vs. 4.9%, p=0.001), as was UI (33.1% vs. 18.3%, p=0.001). Multivariate analysis showed that IS practice (odds ratio [OR] 2.99, 95% confidence interval [CI] 1.29-6.87, p=0.010) and body mass index (BMI) (OR 1.14, 95% CI 1.01-1.28, p=0.033) were significantly linked to AI when taking into account major confounding factors (age and births). In the IS group, AI was mainly represented by loss of flatus in 84%. High-level sport appears to be a significant independent risk factor for AI in healthy young women. These results suggest that preventive measures, such as pelvic floor muscle training, may be proposed for this young population.

  1. GHRSST Level 2P North Atlantic Regional Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-19 satellite produced by NEODAAS (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Level 2P swath-based Group for High Resolution Sea Surface Temperature (GHRSST) dataset for the North Atlantic area from the Advanced Very High Resolution...

  2. GHRSST Level 2P North Atlantic Regional Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-18 satellite produced by NEODAAS (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Level 2P swath-based Group for High Resolution Sea Surface Temperature (GHRSST) dataset for the North Atlantic area from the Advanced Very High Resolution...

  3. GHRSST Level 2P North Atlantic Regional Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-17 satellite produced by NEODAAS (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Level 2P swath-based Group for High Resolution Sea Surface Temperature (GHRSST) dataset for the North Atlantic area from the Advanced Very High Resolution...

  4. GHRSST Level 3C sub-skin Sea Surface Temperature from the Geostationary Operational Environmental Satellites (GOES 13) Imager in East position (GDS V2) produced by OSI SAF (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A regional Group for High Resolution Sea Surface Temperature (GHRSST) Level 3 Collated (L3C) dataset for the America Region (AMERICAS) based on retrievals from the...

  5. Comparison of surface vacuum ultraviolet emissions with resonance level number densities. II. Rare-gas plasmas and Ar-molecular gas mixtures

    Energy Technology Data Exchange (ETDEWEB)

    Boffard, John B., E-mail: jboffard@wisc.edu; Lin, Chun C. [Department of Physics, University of Wisconsin, Madison, Wisconsin 53706 (United States); Wang, Shicong; Wendt, Amy E. [Department of Electrical and Computer Engineering, University of Wisconsin, Madison, Wisconsin 53706 (United States); Culver, Cody [Materials Science Program, University of Wisconsin, Madison, Wisconsin 53706 (United States); Radovanov, Svetlana; Persing, Harold [Applied Materials Inc., Gloucester, Massachusetts 01939 (United States)

    2015-03-15

    Vacuum ultraviolet (VUV) emissions from excited plasma species can play a variety of roles in processing plasmas, including damaging the surface properties of materials used in semiconductor processing. Depending on their wavelength, VUV photons can easily transmit thin upper dielectric layers and affect the electrical characteristics of the devices. Despite their importance, measuring VUV fluxes is complicated by the fact that few materials transmit at VUV wavelengths, and both detectors and windows are easily damaged by plasma exposure. The authors have previously reported on measuring VUV fluxes in pure argon plasmas by monitoring the concentrations of Ar(3p{sup 5}4s) resonance atoms that produce the VUV emissions using noninvasive optical emission spectroscopy in the visible/near-infrared wavelength range [Boffard et al., J. Vac. Sci. Technol., A 32, 021304 (2014)]. Here, the authors extend this technique to other rare-gases (Ne, Kr, and Xe) and argon-molecular gas plasmas (Ar/H{sub 2}, Ar/O{sub 2}, and Ar/N{sub 2}). Results of a model for VUV emissions that couples radiation trapping and the measured rare-gas resonance level densities are compared to measurements made with both a calibrated VUV photodiode and a sodium salicylate fluorescence detection scheme. In these more complicated gas mixtures, VUV emissions from a variety of sources beyond the principal resonance levels of the rare gases are found to contribute to the total VUV flux.

  6. The safety case in support of the license application of the surface repository of low-level waste in Dessel, Belgium

    International Nuclear Information System (INIS)

    Wacquier, William; Cool, Wim

    2014-01-01

    The modern concept of the safety case, developed by the OECD/NEA for geological repositories of high- and medium-level waste has been successfully applied by ONDRAF/ NIRAS for a surface repository for Category A waste (i.e. low-level waste) in Belgium in the current project phase 2006-2012. This resulted in the submission on 31 January 2013 by ONDRAF/NIRAS of an application for a 'construction and operation license' to the safety authorities. The benefits of using the notion of the safety case have been that: i) safety has been incorporated in an integrated manner within all assessment basis, design and safety assessment activities; ii) the process of development of the license application has gained in clarity and traceability; iii) the documentation of the license application contains multiple lines of argumentation for safety rather than argumentation based only on quantitative radiological impact calculations. To offer a comprehensive view on the safety argumentation and its development, it has been found useful to develop the argumentation not only along a safety statements structure but also along the safety report structure. (authors)

  7. Biodegradation of hydrocarbon mixtures in surface waters at environmentally relevant levels - Effect of inoculum origin on kinetics and sequence of degradation.

    Science.gov (United States)

    Birch, Heidi; Hammershøj, Rikke; Comber, Mike; Mayer, Philipp

    2017-10-01

    Biodegradation is a dominant removal process for many organic pollutants, and biodegradation tests serve as tools for assessing their environmental fate within regulatory risk assessment. In simulation tests, the inoculum is not standardized, varying in microbial quantity and quality, thereby potentially impacting the observed biodegradation kinetics. In this study we investigated the effect of inoculum origin on the biodegradation kinetics of hydrocarbons for five inocula from surface waters varying in urbanization and thus expected pre-exposure to petroleum hydrocarbons. A new biodegradation method for testing mixtures of hydrophobic chemicals at trace concentrations was demonstrated: Aqueous solutions containing 9 hydrocarbons were generated by passive dosing and diluted with surface water resulting in test systems containing native microorganisms exposed to test substances at ng-μg/L levels. Automated Headspace Solid Phase Microextraction coupled to GC-MS was applied directly to these test systems to determine substrate depletion relative to abiotic controls. Lag phases were generally less than 8 days. First order rate constants were within one order of magnitude for each hydrocarbon in four of the five waters but lower in water from a rural lake. The sequence of degradation between the 9 hydrocarbons showed similar patterns in the five waters indicating the potential for using selected hydrocarbons for benchmarking between biodegradation tests. Degradation half-times were shorter than or within one order of magnitude of BioHCwin predictions for 8 of 9 hydrocarbons. These results showed that location choice is important for biodegradation kinetics and can provide a relevant input to aquatic exposure and fate models. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Radioactivity levels of 238U and 232Th, the α and β activities and associated dose rates from surface soil in Ulu Tiram, Malaysia

    International Nuclear Information System (INIS)

    Abdul Rahman, A.T.; Ramli, A.T.

    2007-01-01

    A survey was carried out to determine terrestrial gamma radiation dose rates, the concentration level of 238 U and 232 Th and α and β activities for the surface soil in Ulu Tiram, Malaysia. A 125 measurements were performed using a NaI(Tl) gamma-ray detector with crystal size of 1' x 1' on 15 soil samples collected from the site area about 102 km 2 . 238 U and 232 Th concentrations were determined in soils by using hyper pure germanium (HPGe) gamma-ray spectrometry. The activity of α and β from the surface soil was counted by using alpha beta counting system. The average value of 238 U and 232 Th concentrations in soil samples collected are 3.63±0.39 ppm within the range of 1.74±0.20 to 4.58±0.48 and 43.00±2.31 ppm within the range of 10.68±0.76 to 82.10±4.01 ppm, respectively. The average estimate of α and β activity in soil samples collected are 0.65±0.09 Bq x g -1 and 0.68±0.08 Bq x g -1 , respectively. The average of terrestrial gamma-radiation dose rates measured in Ulu Tiram was found to be 200 nGy x h -1 , within the range of 96 to 409 nGy x h -1 . The population weighted outdoor annual effective dose was 1.2 mSv. (author)

  9. A Statistical Analysis of the Relationship between Brown Haze and Surface Air Pollution Levels on Respiratory Hospital Admissions in Auckland, New Zealand

    Directory of Open Access Journals (Sweden)

    Kim Natasha Dirks

    2017-11-01

    Full Text Available Eleven years of hospital admissions data for Auckland, New Zealand for respiratory conditions are analyzed using a Poisson regression modelling approach, incorporating a spline function to represent time, based on a detailed record of haze events and surface air pollution levels over an eleven-year period, taking into account the daily average temperature and humidity, the day of the week, holidays and trends over time. NO2 was the only pollutant to show a statistically significant increase (p = 0.009 on the day of the haze event for the general population. Ambient concentrations of CO, NO and NO2 were significantly associated with admissions with an 11-day lag period for the 0–14 year age group and a 5–7 day lag period for the 65+ year age group. A 3-day lag period was found for the 15–64 year age group for CO, NO and PM10. Finally, the incidence of brown haze was linked to significant increases in hospital admissions. A lag period of 5 days was recorded between haze and subsequent increases in admissions for the 0–14 year age group and the 65+ group and an 11-day lag for the 15–64 year age group. The results provide the first statistical link between Auckland brown haze events, surface air pollution and respiratory health. Medical institutions and practitioners could benefit from improved capacity to predict Auckland’s brown haze events in order prepare for the likely increases in respiratory admissions over the days ahead.

  10. AVHRR Pathfinder Version 5.2 Level 3 Collated (L3C) Global 4km Sea Surface Temperature for 1981-2012

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The AVHRR Pathfinder Version 5.2 Sea Surface Temperature data set (PFV52) is a collection of global, twice-daily 4km sea surface temperature data produced in a...

  11. Changing serum levels of quantitative hepatitis B surface antigen and hepatitis B virus DNA in hepatitis B virus surface antigen carriers: A follow-up study of an elderly cohort

    Directory of Open Access Journals (Sweden)

    Yuan-Hung Kuo

    2015-02-01

    Full Text Available This study was to elucidate longitudinally quantitative changes of hepatitis B virus (HBV surface antigen (HBsAg and HBV DNA in elder HBsAg carriers in a community. Among 1002 residents screened for HBsAg in 2005, 405 responded to this follow-up study in 2010. Fifty-nine (14.6% were HBsAg carriers in 2005; HBsAg quantification and HBV DNA were measured. HBsAg quantification (cutoff 1600 IU/mL and HBV DNA (cutoff 2000 IU/mL were combined to stratify the participants between two screens. A total of 30 men and 29 women with a mean age of 63.9 ± 7.9 years were enrolled. Quantitative levels of HBsAg and HBV DNA were significantly correlated in 2005 (r = 0.509, p < 0.001 and 2010 (r = 0.777, p < 0.001. Concentrations of HBsAg (IU/mL significantly decreased from 2.2 ± 1.0 log in 2005 to 1.7 ± 1.5 log in 2010 (p < 0.001. The level of HBsAg was decreased in 48 (81.4% individuals and HBsAg was undetectable in eight (13.6%. The annual incidence of HBsAg clearance was 2.7%. These 59 HBsAg carriers in 2005 were divided into four groups: low HBsAg low HBV DNA (n = 32, high HBsAg low HBV DNA (n = 5, low HBsAg high HBV DNA (n = 12 and high HBsAg high HBV DNA (n = 10. All 32 individuals in the low HBsAg low HBV DNA group were still in that group in 2010, whereas only two of the high HBsAg high HBV DNA group became inactive. As with a younger cohort in hospital, HBsAg quantification was still well correlated with HBV DNA in elderly HBsAg carriers in the community. Lower levels of both HBsAg and HBV DNA might represent an inactive HBV infection.

  12. Improved exploration of fishery resources through the integration of remotely sensed merged sea level anomaly, chlorophyll concentration, and sea surface temperature

    Science.gov (United States)

    Priya, R. Kanmani Shanmuga; Balaguru, B.; Ramakrishnan, S.

    2013-10-01

    The capabilities of evolving satellite remote sensing technology, combined with conventional data collection techniques, provide a powerful tool for efficient and cost effective management of living marine resources. Fishes are the valuable living marine resources producing food, profit and pleasure to the human community. Variations in oceanic condition play a role in natural fluctuations of fish stocks. The Satellite Altimeter derived Merged Sea Level Anomaly(MSLA) results in the better understanding of ocean variability and mesosclae oceanography and provides good possibility to reveal the zones of high dynamic activity. This study comprised the synergistic analysis of signatures of SEAWIFS derived chlorophyll concentration, National Oceanic and Atmospheric Administration-Advanced Very High Resolution Radiometer(NOAA-AVHRR) derived Sea Surface Temperature and the monthly Merged Sea Level Anomaly data derived from Topex/Poseidon, Jason-1 and ERS-1 Altimeters for the past 7 years during the period from 1998 to 2004. The overlapping Chlorophyll, SST and MSLA were suggested for delineating Potential Fishing Zones (PFZs). The Chlorophyll and SST data set were found to have influenced by short term persistence from days to week while MSLA signatures of respective features persisted for longer duration. Hence, the study used Altimeter derived MSLA as an index for long term variability detection of fish catches along with Chlorophyll and SST images and the maps showing PFZs of the study area were generated. The real time Fishing statistics of the same duration were procured from FSI Mumbai. The catch contours were generated with respect to peak spectra of chlorophyll variation and trough spectra of MSLA and SST variation. The vice- a- versa patterns were observed in the poor catch contours. The Catch Per Unit Effort (CPUE) for each fishing trail was calculated to normalize the fish catch. Based on the statistical analysis the actual CPUEs were classified at each

  13. Isolation, identification, and media optimization of high-level cellulase production by Bacillus sp. BCCS A3, in a fermentation system using response surface methodology.

    Science.gov (United States)

    Kazemi, Aboozar; Rasoul-Amini, Sara; Shahbazi, Maryam; Safari, Azam; Ghasemi, Younes

    2014-01-01

    Cellulases are important glycosyl hydrolase enzymes, which break down cellulose to β-glucose. They have been used widely in biotechnological processing such as bioethanol production. In this work we studied maximizing cellulase production by Bacillus sp. BCCS A3 using response surface methodology (RSM). A good result was attained with these conditions (% w/v): tryptone 0.1, Na₂PO₄ 0.25, (NH₄)₂SO₄ 0.2, MgSO₄ · 7H₂O 0.005, CaCl₂ 0.005, KH₂PO₄ 0.1, NaCl 0.1, sodium carboxymethylcellulose (CMC) 0.75, and pH 9. The cellulase activity in optimized medium was 49.80 U/ml. Moreover, high level of enzyme production was obtained by using fermentor system (50.30 U/ml). Thus, according to the obtained results, this statistical method provided quick identification and integration of key medium details for Bacillus sp. BCCS A3, leading to more cellulase production.

  14. Surface expression and subunit specific control of steady protein levels by the Kv7.2 helix A-B linker.

    Directory of Open Access Journals (Sweden)

    Paloma Aivar

    Full Text Available Kv7.2 and Kv7.3 are the main components of the neuronal voltage-dependent M-current, which is a subthreshold potassium conductance that exerts an important control on neuronal excitability. Despite their predominantly intracellular distribution, these channels must reach the plasma membrane in order to control neuronal activity. Thus, we analyzed the amino acid sequence of Kv7.2 to identify intrinsic signals that may control its surface expression. Removal of the interlinker connecting helix A and helix B of the intracellular C-terminus produces a large increase in the number of functional channels at the plasma membrane. Moreover, elimination of this linker increased the steady-state amount of protein, which was not associated with a decrease of protein degradation. The magnitude of this increase was inversely correlated with the number of helix A - helix B linkers present in the tetrameric channel assemblies. In contrast to the remarkable effect on the amount of Kv7.2 protein, removal of the Kv7.2 linker had no detectable impact on the steady-state levels of Kv7.3 protein.

  15. Plantar pressure differences among adults with mild flexible flatfoot, severe flexible flatfoot and normal foot when walking on level surface, walking upstairs and downstairs.

    Science.gov (United States)

    Zhai, Jun Na; Wang, Jue; Qiu, Yu Sheng

    2017-04-01

    [Purpose] This study observed the plantar pressure between flexible flatfoot and normal foot on different walking conditions to find out if flexible flatfoot needs the treatment and how the plantar pressure change while walking upstairs and downstairs. [Subjects and Methods] Fifteen adults with mild flexible flatfoot, fifteen adults with severe flexible flatfoot and fifteen adults with normal foot were examined while walking on a level surface, walking up and down 10 cm and 20 cm stairs. The max force and the arch index were acquired using the RSscan system. The repeated measures ANOVA was performed to analyze the data. [Results] Compared with normal foot, both max force and arch index of severe flatfoot were significantly increased on different walking conditions. When walking down 10 cm and 20 cm stairs, the plantar data of both normal foot and flatfoot were significantly increased. [Conclusion] The plantar pressure of severe flexible flatfoot were significantly larger than that of normal foot on different walking conditions. In addition, the arches of both normal foot and flatfoot were obviously deformed when walking downstairs. It is therefore necessary to be treated for severe flexible flatfoot to prevent further deformation.

  16. Virus-like particle production with yeast: ultrastructural and immunocytochemical insights into Pichia pastoris producing high levels of the Hepatitis B surface antigen

    Directory of Open Access Journals (Sweden)

    Adnan Ahmad

    2011-06-01

    Full Text Available Abstract Background A protective immune response against Hepatitis B infection can be obtained through the administration of a single viral polypeptide, the Hepatitis B surface antigen (HBsAg. Thus, the Hepatitis B vaccine is generated through the utilization of recombinant DNA technology, preferentially by using yeast-based expression systems. However, the polypeptide needs to assemble into spherical particles, so-called virus-like particles (VLPs, to elicit the required protective immune response. So far, no clear evidence has been presented showing whether HBsAg assembles in vivo inside the yeast cell into VLPs or later in vitro during down-stream processing and purification. Results High level production of HBsAg was carried out with recombinant Pichia pastoris using the methanol inducible AOX1 expression system. The recombinant vaccine was isolated in form of VLPs after several down-stream steps from detergent-treated cell lysates. Search for the intracellular localization of the antigen using electron microscopic studies in combination with immunogold labeling revealed the presence of HBsAg in an extended endoplasmic reticulum where it was found to assemble into defined multi-layered, lamellar structures. The distance between two layers was determined as ~6 nm indicating that these lamellas represent monolayers of well-ordered HBsAg subunits. We did not find any evidence for the presence of VLPs within the endoplasmic reticulum or other parts of the yeast cell. Conclusions It is concluded that high level production and intrinsic slow HBsAg VLP assembly kinetics are leading to retention and accumulation of the antigen in the endoplasmic reticulum where it assembles at least partly into defined lamellar structures. Further transport of HBsAg to the Golgi apparatus is impaired thus leading to secretory pathway disfunction and the formation of an extended endoplasmic reticulum which bulges into irregular cloud-shaped formations. As VLPs were

  17. GHRSST Level 3C North Atlantic Regional (NAR) subskin Sea Surface Temperature from Metop/AVHRR (GDS V2) produced by OSI SAF (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) dataset for the North Atlantic Region (NAR) derived from the Advanced Very High Resolution Radiometer...

  18. GHRSST Level 2P North Atlantic Regional Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-16 satellite (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for HIgh Resolution Sea Surface Temperature (GHRSST) dataset for the North Atlantic Region (NAR) from the Advanced Very High Resolution Radiometer (AVHRR) on...

  19. GHRSST Level 2P North Atlantic Regional Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-17 satellite (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) dataset for the North Atlantic Region (NAR) from the Advanced Very High Resolution Radiometer (AVHRR) on...

  20. GHRSST Level 2P North Atlantic Regional Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-18 satellite (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for HIgh Resolution Sea Surface Temperature (GHRSST) dataset for the North Atlantic Region (NAR) from the Advanced Very High Resolution Radiometer (AVHRR) on...

  1. GHRSST Level 3P North Atlantic Regional Subskin Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on NOAA-19 (GDS version 1)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for HIgh Resolution Sea Surface Temperature (GHRSST) dataset for the North Atlantic Region (NAR) from the Advanced Very High Resolution Radiometer (AVHRR) on...

  2. GHRSST Level 3C North Atlantic Regional Subskin Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on NOAA-19 (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A Group for High Resolution Sea Surface Temperature (GHRSST) dataset for the North Atlantic Region (NAR) from the Advanced Very High Resolution Radiometer (AVHRR) on...

  3. GHRSST Level 3U Global Subskin Sea Surface Temperature from the WindSat Polarimetric Radiometer on the Coriolis satellite (GDS version 2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The WindSat Polarimetric Radiometer, launched on January 6, 2003 aboard the Department of Defense Coriolis satellite, was designed to measure the ocean surface wind...

  4. A study of angle-resolved photoemission extended fine structure as applied to the Ni 3p, Cu 3s, and Cu 3p core levels of the respective clean (111) surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Huff, W.R.A.; Moler, E.J.; Kellar, S.A. [Lawrence Berkeley National Lab., CA (United States)] [and others

    1997-04-01

    The first non-s initial state angle-resolved photoemission extended fine structure (ARPEFS) study of clean surfaces for the purpose of further understanding the technique is reported. The surface structure sensitivity of ARPEFS applied to clean surfaces and to arbitrary initial states is studied using normal photoemission data taken from the Ni 3p core levels of a Ni(111) single crystal and the Cu 3s and the Cu 3p core-levels of a Cu(111) single crystal. The Fourier transforms of these clean surface data are dominated by backscattering. Unlike the s initial state data, the p initial state data show a peak in the Fourier transform corresponding to in-plane scattering from the six nearest-neighbors to the emitter. Evidence was seen for single-scattering events from in the same plane as the emitters and double-scattering events. Using a newly developed, multiple-scattering calculation program, ARPEFS data from clean surfaces and from p initial states can be modeled to high precision. Although there are many layers of emitters when measuring photoemission from a clean surface, test calculations show that the ARPEFS signal is dominated by photoemission from atoms in the first two crystal layers. Thus, ARPEFS applied to clean surfaces is sensitive to surface reconstruction. The known contraction of the first two Cu(111) layers is confirmed. The best-fit calculation for clean Ni(111) indicates an expansion of the first two layers. To better understand the ARPEFS technique, the authors studied s and non-s initial state photoemission from clean metal surfaces.

  5. Acute mental disorders and short and long term morbidity in patients with third degree flame burn: A population-based outcome study of 96,451 patients from the Nationwide Inpatient Sample (NIS) database (2001-2011).

    Science.gov (United States)

    Mahendraraj, Krishnaraj; Durgan, Diane M; Chamberlain, Ronald S

    2016-12-01

    Although burn patients with preexisting mood disorders have been shown to have diminished clinical recovery, acute mental disorders (AMD) are often unrecognized despite a link with post-traumatic stress disorder and social maladjustment later on. This study assessed the clinical profile of a large cohort of burn patients who developed AMD compared to those with chronic mental illness (CMI) and those without mental health problems to assess the impact of AMI on burn outcomes. Admission data on 96,451 patients with third degree flame burns was abstracted from the Nationwide Inpatient Sample (NIS) Database from 2001 to 2011. AMD was defined as adjustment disorder (ICD-10 codes F43.2-F43.29) and acute stress disorder (F43.0), while CMI was defined as major depressive disorder (F33.0-F33.9) and bipolar disorder (F31.0-F31.9). Data was compared across three subgroups: AMD, CMI, and patients without any mood disorders. Categorical variables were compared using the Chi-square test, and continuous variables were compared using Student t-test and analysis of variance (ANOVA). Multivariate analysis using the "backward Wald" method was performed to calculate odds ratios (OR) and determine independent factors which increased the risk of developing AMD after burn. 979 (1%) burn patients were diagnosed with AMD, compared to 5971 (6.2%) with CMI and 89,501 (92.8%) without mood disorders at the time of the burn. Patients with AMD were significantly younger, predominantly male and Caucasian. Patients with AMD had a higher frequency of multiple third-degree burn sites. AMD patients had a significantly longer length of hospitalization and shorter actuarial survival. More AMD patients lacked social or family support, suffered from alcoholism or illicit drug abuse, and had a history of psychological trauma or self-inflicted injuries compared to other groups. After burn, 4.9% of AMD patients developed burn wound infections, 5.0% had nutritional deficiencies, 1.7% had skin graft failure

  6. Analysis of surface leaching processes in vitrified high-level nuclear wastes using in-situ raman imaging and atomistic modeling. 1998 annual progress report

    International Nuclear Information System (INIS)

    Clark, D.E.; Simmons, J.H.

    1998-01-01

    'The research objective was to test and develop optical methods for real-time, remote and in-situ testing of corrosion processes on the surface of vitrified nuclear wastes. This report summarizes the research conducted in the first 1.5 years of a 3 year grant. At this point, the authors have identified the conditions for optimal tests and demonstrated that both IR reflection and Raman spectroscopies can be used to determine the dealkalization process in the surface of simple glasses in real time.'

  7. Physiological response of Pichia pastoris GS115 to methanol-induced high level production of the Hepatitis B surface antigen: catabolic adaptation, stress responses, and autophagic processes.

    Science.gov (United States)

    Vanz, Ana Leticia; Lünsdorf, Heinrich; Adnan, Ahmad; Nimtz, Manfred; Gurramkonda, Chandrasekhar; Khanna, Navin; Rinas, Ursula

    2012-08-08

    Pichia pastoris is an established eukaryotic host for the production of recombinant proteins. Most often, protein production is under the control of the strong methanol-inducible aox1 promoter. However, detailed information about the physiological alterations in P. pastoris accompanying the shift from growth on glycerol to methanol-induced protein production under industrial relevant conditions is missing. Here, we provide an analysis of the physiological response of P. pastoris GS115 to methanol-induced high-level production of the Hepatitis B virus surface antigen (HBsAg). High product titers and the retention of the protein in the endoplasmic reticulum (ER) are supposedly of major impact on the host physiology. For a more detailed understanding of the cellular response to methanol-induced HBsAg production, the time-dependent changes in the yeast proteome and ultrastructural cell morphology were analyzed during the production process. The shift from growth on glycerol to growth and HBsAg production on methanol was accompanied by a drastic change in the yeast proteome. In particular, enzymes from the methanol dissimilation pathway started to dominate the proteome while enzymes from the methanol assimilation pathway, e.g. the transketolase DAS1, increased only moderately. The majority of methanol was metabolized via the energy generating dissimilatory pathway leading to a corresponding increase in mitochondrial size and numbers. The methanol-metabolism related generation of reactive oxygen species induced a pronounced oxidative stress response (e.g. strong increase of the peroxiredoxin PMP20). Moreover, the accumulation of HBsAg in the ER resulted in the induction of the unfolded protein response (e.g. strong increase of the ER-resident disulfide isomerase, PDI) and the ER associated degradation (ERAD) pathway (e.g. increase of two cytosolic chaperones and members of the AAA ATPase superfamily) indicating that potential degradation of HBsAg could proceed via the

  8. Physiological response of Pichia pastoris GS115 to methanol-induced high level production of the Hepatitis B surface antigen: catabolic adaptation, stress responses, and autophagic processes

    Science.gov (United States)

    2012-01-01

    Background Pichia pastoris is an established eukaryotic host for the production of recombinant proteins. Most often, protein production is under the control of the strong methanol-inducible aox1 promoter. However, detailed information about the physiological alterations in P. pastoris accompanying the shift from growth on glycerol to methanol-induced protein production under industrial relevant conditions is missing. Here, we provide an analysis of the physiological response of P. pastoris GS115 to methanol-induced high-level production of the Hepatitis B virus surface antigen (HBsAg). High product titers and the retention of the protein in the endoplasmic reticulum (ER) are supposedly of major impact on the host physiology. For a more detailed understanding of the cellular response to methanol-induced HBsAg production, the time-dependent changes in the yeast proteome and ultrastructural cell morphology were analyzed during the production process. Results The shift from growth on glycerol to growth and HBsAg production on methanol was accompanied by a drastic change in the yeast proteome. In particular, enzymes from the methanol dissimilation pathway started to dominate the proteome while enzymes from the methanol assimilation pathway, e.g. the transketolase DAS1, increased only moderately. The majority of methanol was metabolized via the energy generating dissimilatory pathway leading to a corresponding increase in mitochondrial size and numbers. The methanol-metabolism related generation of reactive oxygen species induced a pronounced oxidative stress response (e.g. strong increase of the peroxiredoxin PMP20). Moreover, the accumulation of HBsAg in the ER resulted in the induction of the unfolded protein response (e.g. strong increase of the ER-resident disulfide isomerase, PDI) and the ER associated degradation (ERAD) pathway (e.g. increase of two cytosolic chaperones and members of the AAA ATPase superfamily) indicating that potential degradation of HBsAg could

  9. Levels of antibody to conserved parts of Plasmodium falciparum merozoite surface protein 1 in Ghanaian children are not associated with protection from clinical malaria

    DEFF Research Database (Denmark)

    Dodoo, D; Theander, T G; Kurtzhals, J A

    1999-01-01

    The 19-kDa conserved C-terminal part of the Plasmodium falciparum merozoite surface protein 1 (PfMSP119) is a malaria vaccine candidate antigen, and human antibody responses to PfMSP119 have been associated with protection against clinical malaria. In this longitudinal study carried out in an are...

  10. Tilt optimized flip uniformity (TOFU) RF pulse for uniform image contrast at low specific absorption rate levels in combination with a surface breast coil at 7 Tesla

    NARCIS (Netherlands)

    van Kalleveen, Irene M. L.; Boer, VO; Luijten, Peter R.; Klomp, DWJ

    Purpose: Going to ultrahigh field MRI (e. g., 7 Tesla [ T]), the nonuniformity of the B_1 field and the increased radiofrequency (RF) power deposition become challenging. While surface coils improve the power efficiency in B_1, its field remains nonuniform. In this work, an RF pulse was designed

  11. Alkanols and chlorophenols cause different physiological adaptive responses on the level of cell surface properties and membrane vesicle formation in Pseudomonas putida DOT-T1E.

    Science.gov (United States)

    Baumgarten, Thomas; Vazquez, José; Bastisch, Christian; Veron, Wilfried; Feuilloley, Marc G J; Nietzsche, Sandor; Wick, Lukas Y; Heipieper, Hermann J

    2012-01-01

    In order to cope with the toxicity imposed by the exposure to environmental hydrocarbons, many bacteria have developed specific adaptive responses such as modifications in the cell envelope. Here we compared the influence of n-alkanols and chlorophenols on the surface properties of the solvent-tolerant bacterium Pseudomonas putida DOT-T1E. In the presence of toxic concentrations of n-alkanols, this strain significantly increased its cell surface charge and hydrophobicity with changes depending on the chain length of the added n-alkanols. The adaptive response occurred within 10 min after the addition of the solvent and was demonstrated to be of physiological nature. Contrary to that, chlorophenols of similar hydrophobicity and potential toxicity as the corresponding alkanols caused only minor effects in the surface properties. To our knowledge, this is the first observation of differences in the cellular adaptive response of bacteria to compound classes of quasi equal hydrophobicity and toxicity. The observed adaptation of the physico-chemical surface properties of strain DOT-T1E to the presence of alkanols was reversible and correlated with changes in the composition of the lipopolysaccharide content of the cells. The reaction is explained by previously described reactions allowing the release of membrane vesicles that was demonstrated for cells affected by 1-octanol and heat shock, whereas no membrane vesicles were released after the addition of chlorophenols.

  12. Generic E. coli levels in surface and nontraditional irrigation water in the mid Atlantic in relation to FSMA water quality standards: A CONSERVE study

    Science.gov (United States)

    Introduction: The use of surface (pond and river) and nontraditional (reclaimed wastewater, produce wash water) irrigation water (SNIW) could reduce stress on ground water resources. However, it is essential to understand how these irrigation sources may influence the microbiological safety of fresh...

  13. Understanding the molecular-level chemistry of water plasmas and the effects of surface modification and deposition on a selection of oxide substrates

    Science.gov (United States)

    Trevino, Kristina J.

    2011-12-01

    This dissertation first examines electrical discharges used to study wastewater samples for contaminant detection and abatement. Two different water samples contaminated with differing concentrations of either methanol (MeOH) or methyl tert-butyl ether (MTBE) were used to follow breakdown mechanisms. Emission from CO* was used to monitor the contaminant and for molecular breakdown confirmation through actinometric OES as it can only arise from the carbon-based contaminant in either system. Detection was achieved at concentrations as low as 0.01 ppm, and molecular decomposition was seen at a variety of plasma parameters. This dissertation also explores the vibrational (thetaV), rotational (thetaR) and translational (thetaT) temperatures for a range of diatomic species in different plasma systems. For the majority of the plasma species studied, thetaV are much higher than thetaR and thetaT. This suggests that more energy is partitioned into the vibrational degrees of freedom in our plasmas. The thetaR reported are significantly lower in all the plasma systems studied and this is a result of radical equilibration to the plasma gas temperature. thetaT values show two characteristics; (1) they are less than the thetaV and higher than the theta R and (2) show varying trends with plasma parameters. Radical energetics were examined through comparison of thetaR, thetaT, and thetaV, yielding significant insight on the partitioning of internal and kinetic energies in plasmas. Correlations between energy partitioning results and corresponding radical surface scattering coefficients obtained using our imaging of radicals interacting with surfaces (IRIS) technique are also presented. Another aspect of plasma process chemistry, namely surface modification via plasma treatment, was investigated through characterization of metal oxides (SiOxNy, nat-SiO2, and dep-SiO2) following their exposure to a range of plasma discharges. Here, emphasis was placed on the surface wettability

  14. Analysis of Surface Leaching Processes in Vitrified High-Level Nuclear Wastes Using In-Situ Raman Imaging and Atomistic Modeling - Final Report

    International Nuclear Information System (INIS)

    Simmons, Joseph H.

    2001-01-01

    The in situ analysis of surface conditions of vitrified nuclear wastes can provide an important check of the burial status of radioactive objects without risk of radiation exposure. Raman spectroscopy was initially chosen as the most promising method for testing the surface conditions of glasses undergoing chemical corrosion, and was used extensively during the first year. However, it was determined that infrared reflection spectroscopy was better suited to this particular need and was used for the remaining two years to investigate the surface corrosion behavior of model silicate glasses for extension to nuclear waste glasses. The developed methodology is consistent with the known theory of optical propagation of dielectric media and uses the Kramers-Kronig formalism. The results show that it is possible to study the corrosion of glass by analyzing the glass surface using reflection fast Fourier infrared measurements and the newly developed ''dispersion analysis method.'' The data show how this analysis can be used to monitor the corrosion behavior of vitrified waste glasses over extended periods of storage

  15. Analysis of Surface Leaching Processes in Vitrified High-Level Nuclear Wastes Using In-Situ Raman Imaging and Atomistic Modeling - Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, Joseph H.

    2001-04-24

    The in situ analysis of surface conditions of vitrified nuclear wastes can provide an important check of the burial status of radioactive objects without risk of radiation exposure. Raman spectroscopy was initially chosen as the most promising method for testing the surface conditions of glasses undergoing chemical corrosion, and was used extensively during the first year. However, it was determined that infrared reflection spectroscopy was better suited to this particular need and was used for the remaining two years to investigate the surface corrosion behavior of model silicate glasses for extension to nuclear waste glasses. The developed methodology is consistent with the known theory of optical propagation of dielectric media and uses the Kramers-Kronig formalism. The results show that it is possible to study the corrosion of glass by analyzing the glass surface using reflection fast Fourier infrared measurements and the newly developed ''dispersion analysis method.'' The data show how this analysis can be used to monitor the corrosion behavior of vitrified waste glasses over extended periods of storage.

  16. Effect of the electrostatic surface potential on the oligomerization of full-length human recombinant prion protein at single-molecule level

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Bin; Xu, Bingqian, E-mail: bxu@engr.uga.edu [Single Molecule Study Laboratory, College of Engineering and Nanoscale Science, and Engineering Center, University of Georgia, Athens, Georgia 30605 (United States); Lou, Zhichao [Single Molecule Study Laboratory, College of Engineering and Nanoscale Science, and Engineering Center, University of Georgia, Athens, Georgia 30605 (United States); College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 210016 (China); Zhang, Haiqian [College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 210016 (China)

    2016-03-21

    The electrostatic surface potential (ESP) of prion oligomers has critical influences on the aggregating processes of the prion molecules. The atomic force microscopy (AFM) and structural simulation were combined to investigate the molecular basis of the full-length human recombinant prion oligomerization on mica surfaces. The high resolution non-intrusive AFM images showed that the prion oligomers formed different patterns on mica surfaces at different buffer pH values. The basic binding units for the large oligomers were determined to be prion momoners (Ms), dimers (Ds), and trimers (Ts). The forming of the D and T units happened through the binding of hydrophobic β-sheets of the M units. In contrast, the α-helices of these M, D, and T units were the binding areas for the formation of large oligomers. At pH 4.5, the binding units M, D, and T showed clear polarized ESP distributions on the surface domains, while at pH 7.0, they showed more evenly distributed ESPs. Based on the conformations of oligomers observed from AFM images, the D and T units were more abundantly on mica surface at pH 4.5 because the ESP re-distribution of M units helped to stabilize these larger oligomers. The amino acid side chains involved in the binding interfaces were stabilized by hydrogen bonds and electrostatic interactions. The detailed analysis of the charged side chains at pH 4.5 indicated that the polarized ESPs induced the aggregations among M, D, and T to form larger oligomers. Therefore, the hydrogen bonds and electrostatic interactions worked together to form the stabilized prion oligomers.

  17. Effect of the electrostatic surface potential on the oligomerization of full-length human recombinant prion protein at single-molecule level

    Science.gov (United States)

    Wang, Bin; Lou, Zhichao; Zhang, Haiqian; Xu, Bingqian

    2016-03-01

    The electrostatic surface potential (ESP) of prion oligomers has critical influences on the aggregating processes of the prion molecules. The atomic force microscopy (AFM) and structural simulation were combined to investigate the molecular basis of the full-length human recombinant prion oligomerization on mica surfaces. The high resolution non-intrusive AFM images showed that the prion oligomers formed different patterns on mica surfaces at different buffer pH values. The basic binding units for the large oligomers were determined to be prion momoners (Ms), dimers (Ds), and trimers (Ts). The forming of the D and T units happened through the binding of hydrophobic β-sheets of the M units. In contrast, the α-helices of these M, D, and T units were the binding areas for the formation of large oligomers. At pH 4.5, the binding units M, D, and T showed clear polarized ESP distributions on the surface domains, while at pH 7.0, they showed more evenly distributed ESPs. Based on the conformations of oligomers observed from AFM images, the D and T units were more abundantly on mica surface at pH 4.5 because the ESP re-distribution of M units helped to stabilize these larger oligomers. The amino acid side chains involved in the binding interfaces were stabilized by hydrogen bonds and electrostatic interactions. The detailed analysis of the charged side chains at pH 4.5 indicated that the polarized ESPs induced the aggregations among M, D, and T to form larger oligomers. Therefore, the hydrogen bonds and electrostatic interactions worked together to form the stabilized prion oligomers.

  18. Effect of surface passivation by SiN/SiO{sub 2} of AlGaN/GaN high-electron mobility transistors on Si substrate by deep level transient spectroscopy method

    Energy Technology Data Exchange (ETDEWEB)

    Gassoumi, Malek, E-mail: malek.gassoumi@fsm.rnu.tn; Mosbahi, Hana; Zaidi, Mohamed Ali [Universite deMonastir, Laboratoire de Micro-Optoelectroniques et Nanostructures, Faculte des Sciences de Monastir (Tunisia); Gaquiere, Christophe [Universite des Sciences et Technologies de Lille, Institut d' Electronique de Microelectronique et de Nanotechnologie IEMN, Departement hyperfrequences et Semiconducteurs (France); Maaref, Hassen [Universite deMonastir, Laboratoire de Micro-Optoelectroniques et Nanostructures, Faculte des Sciences de Monastir (Tunisia)

    2013-07-15

    Device performance and defects in AlGaN/GaN high-electron mobility transistors have been correlated. The effect of SiN/SiO{sub 2} passivation of the surface of AlGaN/GaN high-electron mobility transistors on Si substrates is reported on DC characteristics. Deep level transient spectroscopy (DLTS) measurements were performed on the device after the passivation by a (50/100 nm) SiN/SiO{sub 2} film. The DLTS spectra from these measurements showed the existence of the same electron trap on the surface of the device.

  19. Ice Surfaces

    Science.gov (United States)

    Shultz, Mary Jane

    2017-05-01

    Ice is a fundamental solid with important environmental, biological, geological, and extraterrestrial impact. The stable form of ice at atmospheric pressure is hexagonal ice, Ih. Despite its prevalence, Ih remains an enigmatic solid, in part due to challenges in preparing samples for fundamental studies. Surfaces of ice present even greater challenges. Recently developed methods for preparation of large single-crystal samples make it possible to reproducibly prepare any chosen face to address numerous fundamental questions. This review describes preparation methods along with results that firmly establish the connection between the macroscopic structure (observed in snowflakes, microcrystallites, or etch pits) and the molecular-level configuration (detected with X-ray or electron scattering techniques). Selected results of probing interactions at the ice surface, including growth from the melt, surface vibrations, and characterization of the quasi-liquid layer, are discussed.

  20. A lateral flow immunoassay for rapid evaluation of vitellogenin levels in plasma and surface mucus of the copper redhorse (Moxostoma hubbsi).

    Science.gov (United States)

    Maltais, Domynick; Roy, Robert L

    2007-08-01

    We tested a lateral flow immunoassay (LFIA) for detecting vitellogenin (VTG) in plasma and surface mucus of copper redhorse, Moxostoma hubbsi, a threatened fish species. The LFIA detected VTG in samples from estradiol-induced fish, though there was no reaction in samples from noninduced individuals. The minimum detection range was 0.08 to 0.60 microg VTG/ml, comparable to other methods. The LFIA has the potential to detect exposure to estrogenic endocrine-disrupting chemicals.