WorldWideScience

Sample records for surface mre drivers

  1. Dysfunctional MreB inhibits chromosome segregation in Escherichia coli

    DEFF Research Database (Denmark)

    Kruse, Thomas; Møller-Jensen, Jakob; Løbner-Olesen, Anders

    2003-01-01

    The mechanism of prokaryotic chromosome segregation is not known. MreB, an actin homolog, is a shape-determining factor in rod-shaped prokaryotic cells. Using immunofluorescence microscopy we found that MreB of Escherichia coli formed helical filaments located beneath the cell surface. Flow...... cytometric and cytological analyses indicated that MreB-depleted cells segregated their chromosomes in pairs, consistent with chromosome cohesion. Overexpression of wild-type MreB inhibited cell division but did not perturb chromosome segregation. Overexpression of mutant forms of MreB inhibited cell...... division, caused abnormal MreB filament morphology and induced severe localization defects of the nucleoid and of the oriC and terC chromosomal regions. The chromosomal terminus regions appeared cohered in both MreB-depleted cells and in cells overexpressing mutant forms of MreB. Our observations indicate...

  2. The morphogenetic MreBCD proteins of Escherichia coli form an essential membrane-bound complex

    DEFF Research Database (Denmark)

    Kruse, Torben; Bork-Jensen, J.; Gerdes, Kenn

    2005-01-01

    . subtilis and C. crescentus, the mreB gene is essential. However, in E. coli, mreB was inferred not to be essential. Using a tight, conditional gene depletion system, we systematically investigated whether the E. coli mreBCD-encoded components were essential. We found that cells depleted of mreBCD became......D. In contrast, MreB and MreD did not interact in this assay. Thus, we conclude that the E. coli MreBCD form an essential membrane-bound complex. Curiously, MreB did not form cables in cell depleted for MreC, MreD or RodA, indicating a mutual interdependency between MreB filament morphology and cell shape. Based......MreB proteins of Escherichia coli, Bacillus subtilis and Caulobacter crescentus form actin-like cables lying beneath the cell surface. The cables are required to guide longitudinal cell wall synthesis and their absence leads to merodiploid spherical and inflated cells prone to cell lysis. In B...

  3. Field Evaluation of Improved MRE (Meal, Ready-to-Eat), MRE VII, and MRE IV

    Science.gov (United States)

    1987-01-01

    BEVERAGE 8.3 o. 08 ORANGE FLAVORED BEVERAGE 8.3 0. 12 CANDY TOOTSIE ROLL 8. 7 0.09 VANILLA CARAMEL 8.2 0.18 M&M’ S 8.9 o. 08 OTHER HOT SAUCE...ORANGE FLAVORED BEVERAGE 8.0 0.13 CANDY CARAMEL 8. 5 0.15 VANILLA FUDGE BAR 7.3 o. 25 OTHER HOT SAUCE 8.2 0.18 * 8 oz. entree 34 TABLE 12...BEVERAGES COCOA COFFEE CANDY CHOCOLATE FUDGE BAR CARAMEL VANILLA FUDGE CHOCOLATE TOFFEE BAR TABLE 12 Acceptability Ratings of MRE IV (Continued

  4. Evidence for Distinct Functions of MRE11 in Arabidopsis Meiosis

    Science.gov (United States)

    Šamanić, Ivica; Simunić, Juraj; Riha, Karel; Puizina, Jasna

    2013-01-01

    The evolutionary conserved Mre11/Rad50/Nbs1 complex functions as one of the guardians of genome integrity in eukaryotes; it is required for the double-strand break repair, meiosis, DNA checkpoint, and telomere maintenance. To better understand the role of the MRE11 gene in Arabidopsis, we performed comparative analysis of several mre11 alleles with respect to genome stability and meiosis. The mre11-4 and mre11-2 alleles presumably produce truncated MRE11 proteins composed of the first 499 and 529 amino acids, respectively. Although the putative MRE11 truncated proteins differ only by 30 amino acids, the mutants exhibited strikingly different phenotypes in regards to growth morphology, genome stability and meiosis. While the mre11-2 mutants are fully fertile and undergo normal meiosis, the mre11-4 plants are sterile due to aberrant repair of meiotic DNA breaks. Structural homology analysis suggests that the T-DNA insertion in the mre11-4 allele probably disrupted the putative RAD50 interaction and/or homodimerization domain, which is assumed to be preserved in mre11-2 allele. Intriguingly, introgression of the atm-2 mutant plant into the mre11-2 background renders the double mutant infertile, a phenotype not observed in either parent line. This data indicate that MRE11 partially compensates for ATM deficiency in meiosis of Arabidopsis. PMID:24205310

  5. Assessing Resource Assessment for MRE (Invited)

    Science.gov (United States)

    Hanson, H. P.; Bozec, A.; Duerr, A. S.; Rauchenstein, L. T.

    2010-12-01

    The Southeast National Marine Renewable Energy Center at Florida Atlantic University is concerned with marine renewable energy (MRE) recovery from the Florida Current using marine hydrokinetic technology and, in the future, from the thermocline in the Florida Straits via ocean thermal energy conversion. Although neither concept is new, technology improvements and the evolution of policy now warrant optimism for the future of these potentially rich resources. In moving toward commercial-scale deployments of energy-generating systems, an important first step is accurate and unembellished assessment of the resource itself. In short, we must ask: how much energy might be available? The answer to this deceptively simple question depends, of course, on the technology itself - system efficiencies, for example - but it also depends on a variety of other limiting factors such as deployment strategies, environmental considerations, and the overall economics of MRE in the context of competing energy resources. While it is universally agreed that MRE development must occur within a framework of environmental stewardship, it is nonetheless inevitable that there will be trade-offs between absolute environmental protection and realizing the benefits of MRE implementation. As with solar-energy and wind-power technologies, MRE technologies interact with the environment in which they are deployed. Ecological, societal, and even physical resource concerns all require investigation and, in some cases, mitigation. Moreover, the converse - how will the environment affect the equipment? - presents technical challenges that have confounded the seagoing community forever. Biofouling, for example, will affect system efficiency and create significant maintenance and operations issues. Because this will also affect the economics of MRE, nonlinear interactions among the limiting factors complicate the overall issue of resource assessment significantly. While MRE technology development is

  6. Functional Interactions Between Sae2 and the Mre11 Complex

    Science.gov (United States)

    Kim, Hee-Sook; Vijayakumar, Sangeetha; Reger, Mike; Harrison, Jacob C.; Haber, James E.; Weil, Clifford; Petrini, John H. J.

    2008-01-01

    The Mre11 complex functions in double-strand break (DSB) repair, meiotic recombination, and DNA damage checkpoint pathways. Sae2 deficiency has opposing effects on the Mre11 complex. On one hand, it appears to impair Mre11 nuclease function in DNA repair and meiotic DSB processing, and on the other, Sae2 deficiency activates Mre11-complex-dependent DNA-damage-signaling via the Tel1–Mre11 complex (TM) pathway. We demonstrate that SAE2 overexpression blocks the TM pathway, suggesting that Sae2 antagonizes Mre11-complex checkpoint functions. To understand how Sae2 regulates the Mre11 complex, we screened for sae2 alleles that behaved as the null with respect to Mre11-complex checkpoint functions, but left nuclease function intact. Phenotypic characterization of these sae2 alleles suggests that Sae2 functions as a multimer and influences the substrate specificity of the Mre11 nuclease. We show that Sae2 oligomerizes independently of DNA damage and that oligomerization is required for its regulatory influence on the Mre11 nuclease and checkpoint functions. PMID:18245357

  7. Identification of Plasmodium falciparum DNA Repair Protein Mre11 with an Evolutionarily Conserved Nuclease Function.

    Directory of Open Access Journals (Sweden)

    Sugith Babu Badugu

    Full Text Available The eukaryotic Meiotic Recombination protein 11 (Mre11 plays pivotal roles in the DNA damage response (DDR. Specifically, Mre11 senses and signals DNA double strand breaks (DSB and facilitates their repair through effector proteins belonging to either homologous recombination (HR or non-homologous end joining (NHEJ repair mechanisms. In the human malaria parasite Plasmodium falciparum, HR and alternative-NHEJ have been identified; however, little is known about the upstream factors involved in the DDR of this organism. In this report, we identify a putative ortholog of Mre11 in P. falciparum (PfalMre11 that shares 22% sequence similarity to human Mre11. Homology modeling reveals striking structural resemblance of the predicted PfalMre11 nuclease domain to the nuclease domain of Saccharomyces cerevisiae Mre11 (ScMre11. Complementation analyses reveal functional conservation of PfalMre11 nuclease activity as demonstrated by the ability of the PfalMre11 nuclease domain, in conjunction with the C-terminal domain of ScMre11, to functionally complement an mre11 deficient yeast strain. Functional complementation was virtually abrogated by an amino acid substitution in the PfalMre11 nuclease domain (D398N. PfalMre11 is abundant in the mitotically active trophozoite and schizont stages of P. falciparum and is up-regulated in response to DNA damage, suggesting a role in the DDR. PfalMre11 exhibits physical interaction with PfalRad50. In addition, yeast 2-hybrid studies show that PfalMre11 interacts with ScRad50 and ScXrs2, two important components of the well characterized Mre11-Rad50-Xrs2 complex which is involved in DDR signaling and repair in S. cerevisiae, further supporting a role for PfalMre11 in the DDR. Taken together, these findings provide evidence that PfalMre11 is an evolutionarily conserved component of the DDR in Plasmodium.

  8. 6 CFR 37.17 - Requirements for the surface of the driver's license or identification card.

    Science.gov (United States)

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Requirements for the surface of the driver's license or identification card. 37.17 Section 37.17 Domestic Security DEPARTMENT OF HOMELAND SECURITY... specifically ISO/IEC 19794-5:2005(E) Information technology—Biometric Data Interchange Formats—Part 5: Face...

  9. Driver`s behavior and the motion of motorized wheelchair when driving over rough surfaces; Dansa nado fuseichi sokoji no dendo kurumaisu no undo to join no kyodo

    Energy Technology Data Exchange (ETDEWEB)

    Enomoto, A.; Yokomori, M.; Yamaguchi, S. [Meijo University, Aichi (Japan)

    1997-10-01

    We analyzed about the motion of motorized wheelchairs and the driver`s behavior when passing over the small obstacles in place of the rough surface road or the gateway of house and road by experiment. The tested two type wheelchairs are the front wheel drive and the rear wheel drive. The lean angle of head and the pulse rate of driver, the feeling for stability and the yaw angle and the roll angle of the wheelchair bodies, and the deflection angle of front wheels of rear drive. 4 refs., 11 figs., 1 tab.

  10. Modeling driver stop/run behavior at the onset of a yellow indication considering driver run tendency and roadway surface conditions.

    Science.gov (United States)

    Elhenawy, Mohammed; Jahangiri, Arash; Rakha, Hesham A; El-Shawarby, Ihab

    2015-10-01

    The ability to model driver stop/run behavior at signalized intersections considering the roadway surface condition is critical in the design of advanced driver assistance systems. Such systems can reduce intersection crashes and fatalities by predicting driver stop/run behavior. The research presented in this paper uses data collected from two controlled field experiments on the Smart Road at the Virginia Tech Transportation Institute (VTTI) to model driver stop/run behavior at the onset of a yellow indication for different roadway surface conditions. The paper offers two contributions. First, it introduces a new predictor related to driver aggressiveness and demonstrates that this measure enhances the modeling of driver stop/run behavior. Second, it applies well-known artificial intelligence techniques including: adaptive boosting (AdaBoost), random forest, and support vector machine (SVM) algorithms as well as traditional logistic regression techniques on the data in order to develop a model that can be used by traffic signal controllers to predict driver stop/run decisions in a connected vehicle environment. The research demonstrates that by adding the proposed driver aggressiveness predictor to the model, there is a statistically significant increase in the model accuracy. Moreover the false alarm rate is significantly reduced but this reduction is not statistically significant. The study demonstrates that, for the subject data, the SVM machine learning algorithm performs the best in terms of optimum classification accuracy and false positive rates. However, the SVM model produces the best performance in terms of the classification accuracy only. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Nanoporozni polimeri iz prepletenih polimernih mrež

    OpenAIRE

    Utroša, Petra

    2017-01-01

    Prepletene polimerne mreže (ang. »interpenetrating polymer networks«, IPN) predstavljajo posebno vrsto vsestransko uporabnih večkomponentnih polimernih sistemov. Gre za preplet dveh polimernih mrež, ki med seboj nista kovalentno povezani. Tak material vsebuje mikro domene obeh polimernih komponent in tako deloma ohrani lastnosti obeh polimerov. Sinteza IPN običajno poteka v dveh zaporednih reakcijah, z ustreznim izborom monomerov pa je možna tudi sinteza v enem koraku. Pri tem je potrebno...

  12. Different roles of the Mre11 complex in the DNA damage response in Aspergillus nidulans.

    Science.gov (United States)

    Semighini, Camile P; von Zeska Kress Fagundes, Márcia Regina; Ferreira, Joseane Cristina; Pascon, Renata Castiglioni; de Souza Goldman, Maria Helena; Goldman, Gustavo Henrique

    2003-06-01

    The Mre11-Rad50-Nbs1 protein complex has emerged as a central player in the cellular DNA damage response. Mutations in scaANBS1, which encodes the apparent homologue of human Nbs1 in Aspergillus nidulans, inhibit growth in the presence of the anti-topoisomerase I drug camptothecin. We have used the scaANBS1 cDNA as a bait in a yeast two-hybrid screening and report the identification of the A. nidulans Mre11 homologue (mreA). The inactivated mreA strain was more sensitive to several DNA damaging and oxidative stress agents. Septation in A. nidulans is dependent not only on the uvsBATR gene, but also on the mre11 complex. scaANBS1 and mreA genes are both involved in the DNA replication checkpoint whereas mreA is specifically involved in the intra-S-phase checkpoint. ScaANBS1 also participates in G2-M checkpoint control upon DNA damage caused by MMS. In addition, the scaANBS1 gene is also important for ascospore viability, whereas mreA is required for successful meiosis in A. nidulans. Consistent with this view, the Mre11 complex and the uvsCRAD51 gene are highly expressed at the mRNA level during the sexual development.

  13. The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication

    International Nuclear Information System (INIS)

    Mathew, Shomita S.; Bridge, Eileen

    2007-01-01

    Adenovirus type 5 (Ad5) relocalizes and degrades the host DNA repair protein Mre11, and efficiently initiates viral DNA replication. Mre11 associates with Ad E4 mutant DNA replication centers and is important for concatenating viral genomes. We have investigated the role of Mre11 in the E4 mutant DNA replication defect. RNAi-mediated knockdown of Mre11 dramatically rescues E4 mutant DNA replication in cells that do or do not concatenate viral genomes, suggesting that Mre11 inhibits DNA replication independent of genome concatenation. The mediator of DNA damage checkpoint 1 (Mdc1) protein is involved in recruiting and sustaining Mre11 at sites of DNA damage following ionizing radiation. We observe foci formation by Mdc1 in response to viral infection, indicating that this damage response protein is activated. However, knockdown of Mdc1 does not prevent Mre11 from localizing at viral DNA replication foci or rescue E4 mutant DNA replication. Our results are consistent with a model in which Mre11 interferes with DNA replication when it is localized at viral DNA replication foci

  14. Post-transcriptional regulation of MRE11 expression in muscle-invasive bladder tumours.

    Science.gov (United States)

    Martin, Rebecca M; Kerr, Martin; Teo, Mark T W; Jevons, Sarah J; Koritzinsky, Marianne; Wouters, Bradly G; Bhattarai, Selina; Kiltie, Anne E

    2014-02-28

    Predictive assays are needed to help optimise treatment in muscle-invasive bladder cancer, where patients can be treated by either cystectomy or radical radiotherapy. Our finding that low tumour MRE11 expression is predictive of poor response to radiotherapy but not cystectomy was recently independently validated. Here we investigated further the mechanism underlying low MRE11 expression seen in poorly-responding patients. MRE11 RNA and protein levels were measured in 88 bladder tumour patient samples, by real-time PCR and immunohistochemistry respectively, and a panel of eight bladder cancer cell lines was screened for MRE11, RAD50 and NBS1 mRNA and protein expression. There was no correlation between bladder tumour MRE11 protein and RNA scores (Spearman's rho 0.064, p=0.65), suggesting MRE11 is controlled post-transcriptionally, a pattern confirmed in eight bladder cancer cell lines. In contrast, NBS1 and RAD50 mRNA and protein levels were correlated (p=0.01 and p=0.03, respectively), suggesting primary regulation at the level of transcription. MRE11 protein levels were correlated with NBS1 and RAD50 mRNA and protein levels, implicating MRN complex formation as an important determinant of MRE11 expression, driven by RAD50 and NBS1 expression. Our findings of the post-transcriptional nature of the control of MRE11 imply that any predictive assays used in patients need to be performed at the protein level rather than the mRNA level.

  15. Integracija digitalne radio-difuzne mreže mobilne televizije i ćelijske mreže treće generacije

    Directory of Open Access Journals (Sweden)

    Milan Manojle Šunjevarić

    2013-02-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 U radu su prikazani rezultati istraživanja mogućnosti za integraciju radio-difuznih mreža za mobilnu televiziju i ćelijskih mreža treće generacije (3G. Analizirani su trendovi u pogledu razvoja usluge mobilne televizije, i dosadašnja istraživanja koja imaju za cilj traženje optimalnih načina za integraciju različitih tipova mreža. U radu su analizirane postojeće tehnologije za mobilnu televiziju, s posebnim osvrtom na DVB-H (Digital Video Broadcasting - Handheld tehnologiju. Analizirani su preduslovi, razlozi i mogućnosti za integraciju DVB-H i 3G mreže UMTS (Universal Mobile Telecommunications System, a zaključci ovih analiza su potkrepljeni rezultatima praktičnog rada. Na osnovu svih ovih istraživanja donesen je zaključak o opravdanosti realizacije hibridne DVB-H/UMTS mreže.

  16. A Qualitative Study of Soldier Perceptions of the Relative Importance of MRE Portion Size and Variety

    National Research Council Canada - National Science Library

    Bell, R

    1999-01-01

    .... Bliss, Biggs Army Airfield, and Fort Leonard Wood during 1997 to understand how soldiers perceive Meal, Ready-to-Eat portion size and MRE variety and to begin to determine what types of trade offs...

  17. The actin-like MreB cytoskeleton organizes viral DNA replication in bacteria.

    Science.gov (United States)

    Muñoz-Espín, Daniel; Daniel, Richard; Kawai, Yoshikazu; Carballido-López, Rut; Castilla-Llorente, Virginia; Errington, Jeff; Meijer, Wilfried J J; Salas, Margarita

    2009-08-11

    Little is known about the organization or proteins involved in membrane-associated replication of prokaryotic genomes. Here we show that the actin-like MreB cytoskeleton of the distantly related bacteria Escherichia coli and Bacillus subtilis is required for efficient viral DNA replication. Detailed analyses of B. subtilis phage ϕ29 showed that the MreB cytoskeleton plays a crucial role in organizing phage DNA replication at the membrane. Thus, phage double-stranded DNA and components of the ϕ29 replication machinery localize in peripheral helix-like structures in a cytoskeleton-dependent way. Importantly, we show that MreB interacts directly with the ϕ29 membrane-protein p16.7, responsible for attaching viral DNA at the cell membrane. Altogether, the results reveal another function for the MreB cytoskeleton and describe a mechanism by which viral DNA replication is organized at the bacterial membrane.

  18. TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres.

    Science.gov (United States)

    Porro, Antonio; Feuerhahn, Sascha; Lingner, Joachim

    2014-02-27

    Telomeres protect chromosome ends from being recognized as sites of DNA damage. Upon telomere shortening or telomere uncapping induced by loss of telomeric repeat-binding factor 2 (TRF2), telomeres elicit a DNA-damage response leading to cellular senescence. Here, we show that following TRF2 depletion, the levels of the long noncoding RNA TERRA increase and LSD1, which binds TERRA, is recruited to telomeres. At uncapped telomeres, LSD1 associates with MRE11, one of the nucleases implicated in the processing of 3' telomeric G overhangs, and we show that LSD1 is required for efficient removal of these structures. The LSD1-MRE11 interaction is reinforced in vivo following TERRA upregulation in TRF2-deficient cells and in vitro by TERRA-mimicking RNA oligonucleotides. Furthermore, LSD1 enhances the nuclease activity of MRE11 in vitro. Our data indicate that recruitment of LSD1 to deprotected telomeres requires MRE11 and is promoted by TERRA. LSD1 stimulates MRE11 catalytic activity and nucleolytic processing of uncapped telomeres. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  19. Drivers of Antarctic sea-ice expansion and Southern Ocean surface cooling over the past four decades

    Science.gov (United States)

    Purich, Ariaan; England, Matthew

    2017-04-01

    Despite global warming, total Antarctic sea-ice coverage has increased overall during the past four decades. In contrast, the majority of CMIP5 models simulate a decline. In addition, Southern Ocean surface waters have largely cooled, in stark contrast to almost all historical CMIP5 simulations. Subantarctic Surface Waters have cooled and freshened while waters to the north of the Antarctic Circumpolar Current have warmed and increased in salinity. It remains unclear as to what extent the cooling and Antarctic sea-ice expansion is due to natural variability versus anthropogenic forcing; due for example to changes in the Southern Annular Mode (SAM). It is also unclear what the respective role of surface buoyancy fluxes is compared to internal ocean circulation changes, and what the implications are for longer-term climate change in the region. In this presentation we will outline three distinct drivers of recent Southern Ocean surface trends that have each made a significant contribution to regional cooling: (1) wind-driven surface cooling and sea-ice expansion due to shifted westerly winds, (2) teleconnections of decadal variability from the tropical Pacific, and (3) surface cooling and ice expansion due to large-scale Southern Ocean freshening, most likely driven by SAM-related precipitation trends over the open ocean. We will also outline the main reasons why climate models for the most part miss these Southern Ocean cooling trends, despite capturing overall trends in the SAM.

  20. Effects of MreB paralogs on poly-γ-glutamic acid synthesis and cell morphology in Bacillus amyloliquefaciens.

    Science.gov (United States)

    Gao, Weixia; Zhang, Zhongxiong; Feng, Jun; Dang, Yulei; Quan, Yufen; Gu, Yanyan; Wang, Shufang; Song, Cunjiang

    2016-09-01

    Actin-like MreB paralogs play important roles in cell shape maintenance, cell wall synthesis and the regulation of the D,L-endopeptidases, CwlO and LytE. The gram-positive bacteria, Bacillus amyloliquefaciens LL3, is a poly-γ-glutamic acid (γ-PGA) producing strain that contains three MreB paralogs: MreB, Mbl and MreBH. In B. amyloliquefaciens, CwlO and LytE can degrade γ-PGA. In this study, we aimed to test the hypothesis that modulating transcript levels of MreB paralogs would alter the synthesis and degradation of γ-PGA. The results showed that overexpression or inhibition of MreB, Mbl or MreBH had distinct effects on cell morphology and the molecular weight of the γ-PGA products. In fermentation medium, cells of mreB inhibition mutant were 50.2% longer than LL3, and the γ-PGA titer increased by 55.7%. However, changing the expression level of mbl showed only slight effects on the morphology, γ-PGA molecular weight and titer. In the mreBH inhibition mutant, γ-PGA production and its molecular weight increased by 56.7% and 19.4%, respectively. These results confirmed our hypothesis that suppressing the expression of MreB paralogs might reduce γ-PGA degradation, and that improving the cell size could strengthen γ-PGA synthesis. This is the first report of enhanced γ-PGA production via suppression of actin-like MreB paralogs. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  1. Nastup i oglašavanje na društvenim mrežama

    OpenAIRE

    Posavec, Ana

    2016-01-01

    Kontinuirano pojavljivanje novih društvenih mreža i platformi za komunikaciju dokazuje da ovaj fenomen nije samo modni trend, nego sadašnjost i budućnost komunikacije. Već na samom početku razvoja društvenih mreža, to su prepoznali mnogi brandovi. Danas je snažna digitalna prisutnost neophodna za održavanje uspješne tvrtke. U ovom se radu opisuju društvene mreže i oglašavanje na njima. Osim teorijskog dijela, ovaj rad sadrži praktični dio gdje su opisani koraci pri kreiranju oglasa na Faceboo...

  2. Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model.

    Science.gov (United States)

    Balestrini, Alessia; Nicolas, Laura; Yang-Lott, Katherine; Guryanova, Olga A; Levine, Ross L; Bassing, Craig H; Chaudhuri, Jayanta; Petrini, John H J

    2016-02-01

    The Mre11 complex (Mre11, Rad50, and Nbs1) occupies a central node of the DNA damage response (DDR) network and is required for ATM activation in response to DNA damage. Hypomorphic alleles of MRE11 and NBS1 confer embryonic lethality in ATM-deficient mice, indicating that the complex exerts ATM-independent functions that are essential when ATM is absent. To delineate those functions, a conditional ATM allele (ATM(flox)) was crossed to hypomorphic NBS1 mutants (Nbs1(ΔB/ΔB) mice). Nbs1(ΔB/ΔB) Atm(-/-) hematopoietic cells derived by crossing to vav(cre) were viable in vivo. Nbs1(ΔB/ΔB) Atm(-/-) (VAV) mice exhibited a pronounced defect in double-strand break repair and completely penetrant early onset lymphomagenesis. In addition to repair defects observed, fragile site instability was noted, indicating that the Mre11 complex promotes genome stability upon replication stress in vivo. The data suggest combined influences of the Mre11 complex on DNA repair, as well as the responses to DNA damage and DNA replication stress. A novel mouse model was developed, by combining a vav(cre)-inducible ATM knockout mouse with an NBS1 hypomorphic mutation, to analyze ATM-independent functions of the Mre11 complex in vivo. These data show that the DNA repair, rather than DDR signaling functions of the complex, is acutely required in the context of ATM deficiency to suppress genome instability and lymphomagenesis. ©2015 American Association for Cancer Research.

  3. Multiple kernel SVR based on the MRE for remote sensing water depth fusion detection

    Science.gov (United States)

    Wang, Jinjin; Ma, Yi; Zhang, Jingyu

    2018-03-01

    Remote sensing has an important means of water depth detection in coastal shallow waters and reefs. Support vector regression (SVR) is a machine learning method which is widely used in data regression. In this paper, SVR is used to remote sensing multispectral bathymetry. Aiming at the problem that the single-kernel SVR method has a large error in shallow water depth inversion, the mean relative error (MRE) of different water depth is retrieved as a decision fusion factor with single kernel SVR method, a multi kernel SVR fusion method based on the MRE is put forward. And taking the North Island of the Xisha Islands in China as an experimentation area, the comparison experiments with the single kernel SVR method and the traditional multi-bands bathymetric method are carried out. The results show that: 1) In range of 0 to 25 meters, the mean absolute error(MAE)of the multi kernel SVR fusion method is 1.5m,the MRE is 13.2%; 2) Compared to the 4 single kernel SVR method, the MRE of the fusion method reduced 1.2% (1.9%) 3.4% (1.8%), and compared to traditional multi-bands method, the MRE reduced 1.9%; 3) In 0-5m depth section, compared to the single kernel method and the multi-bands method, the MRE of fusion method reduced 13.5% to 44.4%, and the distribution of points is more concentrated relative to y=x.

  4. Magnetic resonance elastography (MRE) of the human brain: technique, findings and clinical applications

    Science.gov (United States)

    Hiscox, Lucy V.; Johnson, Curtis L.; Barnhill, Eric; McGarry, Matt D. J.; Huston 3rd, John; van Beek, Edwin J. R.; Starr, John M.; Roberts, Neil

    2016-12-01

    Neurological disorders are one of the most important public health concerns in developed countries. Established brain imaging techniques such as magnetic resonance imaging (MRI) and x-ray computerised tomography (CT) have been essential in the identification and diagnosis of a wide range of disorders, although usually are insufficient in sensitivity for detecting subtle pathological alterations to the brain prior to the onset of clinical symptoms—at a time when prognosis for treatment is more favourable. The mechanical properties of biological tissue provide information related to the strength and integrity of the cellular microstructure. In recent years, mechanical properties of the brain have been visualised and measured non-invasively with magnetic resonance elastography (MRE), a particularly sensitive medical imaging technique that may increase the potential for early diagnosis. This review begins with an introduction to the various methods used for the acquisition and analysis of MRE data. A systematic literature search is then conducted to identify studies that have specifically utilised MRE to investigate the human brain. Through the conversion of MRE-derived measurements to shear stiffness (kPa) and, where possible, the loss tangent (rad), a summary of results for global brain tissue and grey and white matter across studies is provided for healthy participants, as potential baseline values to be used in future clinical investigations. In addition, the extent to which MRE has revealed significant alterations to the brain in patients with neurological disorders is assessed and discussed in terms of known pathophysiology. The review concludes by predicting the trends for future MRE research and applications in neuroscience.

  5. Zaštita računarskih mreža / Protection of computer networks

    Directory of Open Access Journals (Sweden)

    Milojko Jevtović

    2005-09-01

    Full Text Available U radu su obrađene metode napada, oblici ugrožavanja i vrste pretnji kojima su izložene računarske mreže, kao i moguće metode i tehnička rešenja za zaštitu mreža. Analizirani su efekti pretnji kojima mogu biti izložene računarske mreže i informacije koje se preko njih prenose. Opisana su određena tehnička rešenja koja obezbeđuju potreban nivo zaštite računarskih mreža, kao i mere za zaštitu informacija koje se preko njih prenose. Navedeni su standardi koji se odnose na metode i procedure kriptozaštite informacija u računarskim mrežama. U radu je naveden primer zaštite jedne lokalne računarske mreže. / In this paper different methods of attacks, threats and different forms of dangers to the computer networks are described. The possible models and technical solutions for networks protection are also given. The effects of threats directed to the computer networks and their information are analyzed certain technical solutions that provide necessary protection level of the computer networks as well as measures for information protection are also described. The standards for methods and security procedure for the information in computer networks are enlisted. There is also an example of protecting one local data network (in this paper.

  6. Uporaba simulacijskega modeliranja in metod mrežnega programiranja za primer peke kruha

    OpenAIRE

    Duh, Mojca

    2010-01-01

    Diplomsko delo temelji na razvoju simulacijskega modela za pridelavo pšenice in nadaljnjo peko kruha ter aplikaciji metod mrežnega programiranja projekta peko kruha. Simulacijski model bo temeljil na tehnološki karti, katera bo osnova za ekonomsko analizo te dopolnilne dejavnosti. Vzporedno se bo na istem primeru aplicirala metoda mrežnega programiranja in sicer metoda CPM in PERT metoda. Pri metodi CPM bodo prikazani podatki o najzgodnejših in najpoznejših rokih dogodkov. Pri metodi PERT pri...

  7. MotAB-like machinery drives the movement of MreB filaments during bacterial gliding motility.

    Science.gov (United States)

    Fu, Guo; Bandaria, Jigar N; Le Gall, Anne Valérie; Fan, Xue; Yildiz, Ahmet; Mignot, Tâm; Zusman, David R; Nan, Beiyan

    2018-03-06

    MreB is a bacterial actin that is important for cell shape and cell wall biosynthesis in many bacterial species. MreB also plays crucial roles in Myxococcus xanthus gliding motility, but the underlying mechanism remains unknown. Here we tracked the dynamics of single MreB particles in M. xanthus using single-particle tracking photoactivated localization microscopy. We found that a subpopulation of MreB particles moves rapidly along helical trajectories, similar to the movements of the MotAB-like gliding motors. The rapid MreB motion was stalled in the mutants that carried truncated gliding motors. Remarkably, M. xanthus MreB moves one to two orders of magnitude faster than its homologs that move along with the cell wall synthesis machinery in Bacillus subtilis and Escherichia coli , and this rapid movement was not affected by the inhibitors of cell wall biosynthesis. Our results show that in M. xanthus , MreB provides a scaffold for the gliding motors while the gliding machinery drives the movement of MreB filaments, analogous to the interdependent movements of myosin motors and actin in eukaryotic cells.

  8. An innovative MRE absorber with double natural frequencies for wide frequency bandwidth vibration absorption

    International Nuclear Information System (INIS)

    Sun, Shuaishuai; Yang, Jian; Li, Weihua; Alici, Gursel; Deng, Huaxia; Du, Haiping; Yan, Tianhong

    2016-01-01

    A new design of adaptive tuned vibration absorber was proposed in this study for vibration reduction. The innovation of the new absorber is the adoption of the eccentric mass on the top of the multilayered magnetorheological elastomer (MRE) structure so that this proposed absorber has two vibration modes: one in the torsional direction and the other in translational direction. This property enables the absorber to expand its effective bandwidth and to be more capable of reducing the vibrations especially dealing with those vibrations with multi-frequencies. The innovative MRE absorber was designed and tested on a horizontal vibration table. The test results illustrate that the MRE absorber realized double natural frequencies, both of which are controllable. Inertia’s influence on the dynamic behavior of the absorber is also investigated in order to guide the design of the innovative MRE absorber. Additionally, the experimentally obtained natural frequencies coincide with the theoretical data, which sufficiently verifies the feasibility of this new design. The last part in terms of the vibration absorption ability also proves that both of these two natural frequencies play a great role in absorbing vibration energy. (paper)

  9. Meteorological Drivers of West Antarctic Ice Sheet and Ice Shelf Surface Melt

    Science.gov (United States)

    Scott, R. C.; Nicolas, J. P.; Bromwich, D. H.; Norris, J. R.; Lubin, D.

    2017-12-01

    We identify synoptic patterns and surface energy balance components driving warming and surface melting on the West Antarctic Ice Sheet (WAIS) and ice shelves using reanalysis and satellite remote sensing data from 1973-present. We have developed a synoptic climatology of atmospheric circulation patterns during the summer melt season using k-means cluster and composite analysis of daily 700-mb geopotential height and near-surface air temperature and wind fields from the ECMWF ERA-Interim reanalysis. Surface melt occurrence is detected in satellite passive microwave brightness temperature observations (K-band, horizontal polarization) beginning with the NASA Nimbus-5 Electrically Scanning Microwave Radiometer (ESMR) and continuing with its more familiar descendants SMMR, SSM/I and SSMIS. To diagnose synoptic precursors and physical processes driving surface melt we combine the circulation climatology and multi-decadal records of cloud cover with surface radiative fluxes from the Extended AVHRR Polar Pathfinder (APP-x) project. We identify three distinct modes of regional summer West Antarctic warming since 1979 involving anomalous ridging over West Antarctica (WA) and the Amundsen Sea (AS). During the 1970s, ESMR data reveal four extensive melt events on the Ross Sea sector of the WAIS also linked to AS blocking. We therefore define an Amundsen Sea Blocking Index (ASBI). The ASBI and synoptic circulation pattern occurrence frequencies are correlated with the tropical Pacific (ENSO) and high latitude Southern Annular Mode (SAM) indices and the West Antarctic melt index. Surface melt in WA is favored by enhanced downwelling infrared and turbulent sensible heat fluxes associated with intrusions of warm, moist marine air. Consistent with recent findings from the Atmospheric Radiation Measurement (ARM) West Antarctic Radiation Experiment (AWARE), marine advection to the Ross sector is favored by El Niño conditions in the tropical Pacific and a negative SAM. We also find

  10. Surface covering of downed logs: drivers of a neglected process in dead wood ecology.

    Directory of Open Access Journals (Sweden)

    Mats Dynesius

    2010-10-01

    Full Text Available Many species use coarse woody debris (CWD and are disadvantaged by the forestry-induced loss of this resource. A neglected process affecting CWD is the covering of the surfaces of downed logs caused by sinking into the ground (increasing soil contact, mostly covering the underside of the log, and dense overgrowth by ground vegetation. Such cover is likely to profoundly influence the quality and accessibility of CWD for wood-inhabiting organisms, but the factors affecting covering are largely unknown. In a five-year experiment we determined predictors of covering rate of fresh logs in boreal forests and clear-cuts. Logs with branches were little covered because they had low longitudinal ground contact. For branchless logs, longitudinal ground contact was most strongly related to estimated peat depth (positive relation. The strongest predictor for total cover of branchless logs was longitudinal ground contact. To evaluate the effect on cover of factors other than longitudinal ground contact, we separately analyzed data from only those log sections that were in contact with the ground. Four factors were prominent predictors of percentage cover of such log sections: estimated peat depth, canopy shade (both increasing cover, potential solar radiation calculated from slope and slope aspect, and diameter of the log (both reducing cover. Peat increased cover directly through its low resistance, which allowed logs to sink and soil contact to increase. High moisture and low temperatures in pole-ward facing slopes and under a canopy favor peat formation through lowered decomposition and enhanced growth of peat-forming mosses, which also proved to rapidly overgrow logs. We found that in some boreal forests, peat and fast-growing mosses can rapidly cover logs lying on the ground. When actively introducing CWD for conservation purposes, we recommend that such rapid covering is avoided, thereby most likely improving the CWD's longevity as habitat for many

  11. Uporaba metod mrežnega planiranja na primeru peke vrtankov

    OpenAIRE

    Madžarič, Karla

    2010-01-01

    Raziskava temelji na uporabi metod mrežnega planiranja za primer peke vrtankov. Uporabljeni sta bili dve metodi, in sicer "Critical Path Method" (CPM metoda) in "Program Evaluation and Rewiew Technique" (PERT metoda). S pomočjo omenjenih metod je bil cilj prikazati organizirano načrtovanje in definiranje časovnega zaporedja dejavnosti, nazorno prikazati medsebojne povezave med dejavnostmi in oceniti čas, potreben za izvedbo celotnega projekta ter posameznih aktivnosti pri peki vrtankov. Rezul...

  12. Natural transformation occurs independently of the essential actin-like MreB cytoskeleton in Legionella pneumophila.

    Science.gov (United States)

    Juan, Pierre-Alexandre; Attaiech, Laetitia; Charpentier, Xavier

    2015-11-03

    Natural transformation is the process by which bacteria can actively take up and integrate exogenous DNA thereby providing a source of genetic diversity. Under specific growth conditions the coordinated expression of several genes--a situation referred to as "competence"--allows bacteria to assemble a highly processive and dedicated system that can import high molecular weight DNA. Within the cell these large imported DNA molecules are protected from degradation and brought to the chromosome for recombination. Here, we report elevated expression of mreB during competence in the Gram-negative pathogen Legionella pneumophila. Interestingly a similar observation had previously been reported in the distantly-related Gram-positive organism Bacillus subtilis. MreB is often viewed as the bacterial actin homolog contributing to bacterial morphogenesis by coordinating peptidoglycan-synthesising complexes. In addition MreB is increasingly found to be involved in a growing number of processes including chromosome segregation and motor-driven motility. Using genetic and pharmacological approaches, we examined the possible role of MreB during natural transformation in L. pneumophila. Our data show that natural transformation does not require MreB dynamics and exclude a direct role of MreB filaments in the transport of foreign DNA and its recombination in the chromosome.

  13. MRE: a web tool to suggest foreign enzymes for the biosynthesis pathway design with competing endogenous reactions in mind

    KAUST Repository

    Kuwahara, Hiroyuki

    2016-04-29

    To rationally design a productive heterologous biosynthesis system, it is essential to consider the suitability of foreign reactions for the specific endogenous metabolic infrastructure of a host. We developed a novel web server, called MRE, which, for a given pair of starting and desired compounds in a given chassis organism, ranks biosynthesis routes from the perspective of the integration of new reactions into the endogenous metabolic system. For each promising heterologous biosynthesis pathway, MRE suggests actual enzymes for foreign metabolic reactions and generates information on competing endogenous reactions for the consumption of metabolites. These unique, chassis-centered features distinguish MRE from existing pathway design tools and allow synthetic biologists to evaluate the design of their biosynthesis systems from a different angle. By using biosynthesis of a range of high-value natural products as a case study, we show that MRE is an effective tool to guide the design and optimization of heterologous biosynthesis pathways. The URL of MRE is http://www.cbrc.kaust.edu.sa/mre/.

  14. Effects of frequency- and direction-dependent elastic materials on linearly elastic MRE image reconstructions

    International Nuclear Information System (INIS)

    Perreard, I M; Weaver, J B; Paulsen, K D; Pattison, A J; McGarry, M D J; Doyley, M; Barani, Z; Van Houten, E E

    2010-01-01

    The mechanical model commonly used in magnetic resonance elastography (MRE) is linear elasticity. However, soft tissue may exhibit frequency- and direction-dependent (FDD) shear moduli in response to an induced excitation causing a purely linear elastic model to provide an inaccurate image reconstruction of its mechanical properties. The goal of this study was to characterize the effects of reconstructing FDD data using a linear elastic inversion (LEI) algorithm. Linear and FDD phantoms were manufactured and LEI images were obtained from time-harmonic MRE acquisitions with variations in frequency and driving signal amplitude. LEI responses to artificially imposed uniform phase shifts in the displacement data from both purely linear elastic and FDD phantoms were also evaluated. Of the variety of FDD phantoms considered, LEI appeared to tolerate viscoelastic data-model mismatch better than deviations caused by poroelastic and anisotropic mechanical properties in terms of visual image contrast. However, the estimated shear modulus values were substantially incorrect relative to independent mechanical measurements even in the successful viscoelastic cases and the variations in mean values with changes in experimental conditions associated with uniform phase shifts, driving signal frequency and amplitude were unpredictable. Overall, use of LEI to reconstruct data acquired in phantoms with FDD material properties provided biased results under the best conditions and significant artifacts in the worst cases. These findings suggest that the success with which LEI is applied to MRE data in tissue will depend on the underlying mechanical characteristics of the tissues and/or organs systems of clinical interest.

  15. Germline variants in MRE11/RAD50/NBN complex genes in childhood leukemia

    International Nuclear Information System (INIS)

    Mosor, Maria; Ziółkowska-Suchanek, Iwona; Nowicka, Karina; Dzikiewicz-Krawczyk, Agnieszka; Januszkiewicz–Lewandowska, Danuta; Nowak, Jerzy

    2013-01-01

    The MRE11, RAD50, and NBN genes encode proteins of the MRE11-RAD50-NBN (MRN) complex involved in cellular response to DNA damage and the maintenance of genome stability. In our previous study we showed that the germline p.I171V mutation in NBN may be considered as a risk factor in the development of childhood acute lymphoblastic leukemia (ALL) and some specific haplotypes of that gene may be associated with childhood leukemia. These findings raise important questions about the role of mutations in others genes of the MRN complex in childhood leukemia. The aim of this study was to answer the question whether MRE11 and RAD50 alterations may be associated with childhood ALL or AML. We estimated the frequency of constitutional mutations and polymorphisms in selected regions of MRE11, RAD50, and NBN in the group of 220 children diagnosed with childhood leukemias and controls (n=504/2200). The analysis was performed by specific amplification of region of interest by PCR and followed by multi-temperature single-strand conformation polymorphism (PCR-MSSCP) technique. We performed two molecular tests to examine any potential function of the detected the c.551+19G>A SNP in RAD50 gene. To our knowledge, this is the first analysis of the MRE11, RAD50 and NBN genes in childhood leukemia. The frequency of either the AA genotype or A allele of RAD50-rs17166050 were significantly different in controls compared to leukemia group (ALL+AML) (p<0.0019 and p<0.0019, respectively). The cDNA analysis of AA or GA genotypes carriers has not revealed evidence of splicing abnormality of RAD50 pre-mRNA. We measured the allelic-specific expression of G and A alleles at c.551+19G>A and the statistically significant overexpression of the G allele has been observed. Additionally we confirmed the higher incidence of the p.I171V mutation in the leukemia group (7/220) than among controls (12/2400) (p<0.0001). The formerly reported sequence variants in the RAD50 and MRE11 gene may not constitute a

  16. Drivers of contaminant levels in surface water of China during 2000-2030: Relative importance for illustrative home and personal care product chemicals.

    Science.gov (United States)

    Zhu, Ying; Price, Oliver R; Kilgallon, John; Qi, Yi; Tao, Shu; Jones, Kevin C; Sweetman, Andrew J

    2018-03-21

    Water pollution are among the most critical problems in China and emerging contaminants in surface water have attracted rising attentions in recent years. There is great interest in China's future environmental quality as the national government has committed to a major action plan to improve surface water quality. This study presents methodologies to rank the importance of socioeconomic and environmental drivers to the chemical concentration in surface water during 2000-2030. A case study is conducted on triclosan, a home and personal care product (HPCP) ingredient. Different economic and discharge flow scenarios are considered. Urbanization and wastewater treatment connection rates in rural and urban areas are collected or projected for 2000-2030 for counties across China. The estimated usage increases from ca. 86 to 340 t. However, emissions decreases from 76 to 52 t during 2000-2030 under a modelled Organisation for Economic Co-operation (OECD) economic scenario because of the urbanization, migration and development of wastewater treatment plants/facilities (WWTPs). The estimated national median concentration of triclosan ranges 1.5-8.2 ng/L during 2000-2030 for different scenarios. It peaks in 2009 under the OECD and three of the Intergovernmental Panel on Climate Change (IPCC), A2, B1 and B2 economic scenarios, but in 2025 under A1 economic scenario. Population distribution and surface water discharge flow rates are ranked as the top two drivers to triclosan levels in surface water over the 30 years. The development of urban WWTPs was the most important driver during 2000-2010 and the development of rural works is projected to be the most important in 2011-2030. Projections suggest discharges of ingredients in HPCPs - controlled by economic growth - should be balanced by the major expenditure programme on wastewater treatment in China. Copyright © 2018 Elsevier Ltd. All rights reserved.

  17. Functional Interplay of the Mre11 Nuclease and Ku in the Response to Replication-Associated DNA Damage ▿

    Science.gov (United States)

    Foster, Steven S.; Balestrini, Alessia; Petrini, John H. J.

    2011-01-01

    The Mre11 complex is a central component of the DNA damage response, with roles in damage sensing, molecular bridging, and end resection. We have previously shown that in Saccharomyces cerevisiae, Ku70 (yKu70) deficiency reduces the ionizing radiation sensitivity of mre11Δ mutants. In this study, we show that yKu70 deficiency suppressed the camptothecin (CPT) and methyl methanesulfonate (MMS) sensitivity of nuclease-deficient mre11-3 and sae2Δ mutants in an Exo1-dependent manner. CPT-induced G2/M arrest, γ-H2AX persistence, and chromosome breaks were elevated in mre11-3 mutants. These outcomes were reduced by yKu70 deficiency. Given that the genotoxic effects of CPT are manifest during DNA replication, these data suggest that Ku limits Exo1-dependent double-strand break (DSB) resection during DNA replication, inhibiting the initial processing steps required for homology-directed repair. We propose that Mre11 nuclease- and Sae2-dependent DNA end processing, which initiates DSB resection prevents Ku from engaging DSBs, thus promoting Exo1-dependent resection. In agreement with this idea, we show that Ku affinity for binding to short single-stranded overhangs is much lower than for blunt DNA ends. Collectively, the data define a nonhomologous end joining (NHEJ)-independent, S-phase-specific function of the Ku heterodimer. PMID:21876003

  18. Izložba na mreži – ATLASES: Poetics, Politics, and Performance

    OpenAIRE

    Frančula, Nedjeljko

    2013-01-01

    ATLASES: Poetics, Politics, and Performance je izložba na mreži atlasa iz Specijalne zbirke i Škole geografskih znanosti (Special Collections and School of Geographical Sciences) Sveučilišta u Bristolu (http://uobatlases.net/). Uključeni su atlasi od 1570. do približno 1970. godine. Izložba obuhvaća četiri tematske cjeline. Renaissance Theatres sadrži slavne i manje poznate atlase od kraja 16. do sredine 17. stoljeća., među ostalim, Orteliusov atlas iz 1574., Camdenov iz 1610., Speedov iz...

  19. Mre11 nuclease and C-terminal tail-mediated DDR functions are required for initiating yeast telomere healing.

    Science.gov (United States)

    Bhattacharyya, M K; Matthews, K M; Lustig, A J

    2008-08-01

    Mre11 is a central factor in creating an optimal substrate for telomerase loading and elongation. We have used a G2/M synchronized telomere-healing assay as a tool to separate different functions of Mre11 that are not apparent in null alleles. An analysis of healing efficiencies of several mre11 alleles revealed that both nuclease and C-terminal mutations led to a loss of healing. Interestingly, trans-complementation of the 49 amino acid C-terminal deletion (DeltaC49) and the D16A mutant, deficient in nuclease activity and partially defective in MRX complex formation, restores healing. DeltaC49 provokes Rad53 phosphorylation after treatment with the radiomimetic agent MMS exclusively through the Tel1 pathway, suggesting that a Tel1-mediated function is initiated through the C-terminal tail.

  20. Estimating carbon flux phenology with satellite-derived land surface phenology and climate drivers for different biomes: a synthesis of AmeriFlux observations.

    Science.gov (United States)

    Zhu, Wenquan; Chen, Guangsheng; Jiang, Nan; Liu, Jianhong; Mou, Minjie

    2013-01-01

    Carbon Flux Phenology (CFP) can affect the interannual variation in Net Ecosystem Exchange (NEE) of carbon between terrestrial ecosystems and the atmosphere. In this study, we proposed a methodology to estimate CFP metrics with satellite-derived Land Surface Phenology (LSP) metrics and climate drivers for 4 biomes (i.e., deciduous broadleaf forest, evergreen needleleaf forest, grasslands and croplands), using 159 site-years of NEE and climate data from 32 AmeriFlux sites and MODIS vegetation index time-series data. LSP metrics combined with optimal climate drivers can explain the variability in Start of Carbon Uptake (SCU) by more than 70% and End of Carbon Uptake (ECU) by more than 60%. The Root Mean Square Error (RMSE) of the estimations was within 8.5 days for both SCU and ECU. The estimation performance for this methodology was primarily dependent on the optimal combination of the LSP retrieval methods, the explanatory climate drivers, the biome types, and the specific CFP metric. This methodology has a potential for allowing extrapolation of CFP metrics for biomes with a distinct and detectable seasonal cycle over large areas, based on synoptic multi-temporal optical satellite data and climate data.

  1. Estimating carbon flux phenology with satellite-derived land surface phenology and climate drivers for different biomes: a synthesis of AmeriFlux observations.

    Directory of Open Access Journals (Sweden)

    Wenquan Zhu

    Full Text Available Carbon Flux Phenology (CFP can affect the interannual variation in Net Ecosystem Exchange (NEE of carbon between terrestrial ecosystems and the atmosphere. In this study, we proposed a methodology to estimate CFP metrics with satellite-derived Land Surface Phenology (LSP metrics and climate drivers for 4 biomes (i.e., deciduous broadleaf forest, evergreen needleleaf forest, grasslands and croplands, using 159 site-years of NEE and climate data from 32 AmeriFlux sites and MODIS vegetation index time-series data. LSP metrics combined with optimal climate drivers can explain the variability in Start of Carbon Uptake (SCU by more than 70% and End of Carbon Uptake (ECU by more than 60%. The Root Mean Square Error (RMSE of the estimations was within 8.5 days for both SCU and ECU. The estimation performance for this methodology was primarily dependent on the optimal combination of the LSP retrieval methods, the explanatory climate drivers, the biome types, and the specific CFP metric. This methodology has a potential for allowing extrapolation of CFP metrics for biomes with a distinct and detectable seasonal cycle over large areas, based on synoptic multi-temporal optical satellite data and climate data.

  2. A numerical framework for interstitial fluid pressure imaging in poroelastic MRE.

    Directory of Open Access Journals (Sweden)

    Likun Tan

    Full Text Available A numerical framework for interstitial fluid pressure imaging (IFPI in biphasic materials is investigated based on three-dimensional nonlinear finite element poroelastic inversion. The objective is to reconstruct the time-harmonic pore-pressure field from tissue excitation in addition to the elastic parameters commonly associated with magnetic resonance elastography (MRE. The unknown pressure boundary conditions (PBCs are estimated using the available full-volume displacement data from MRE. A subzone-based nonlinear inversion (NLI technique is then used to update mechanical and hydrodynamical properties, given the appropriate subzone PBCs, by solving a pressure forward problem (PFP. The algorithm was evaluated on a single-inclusion phantom in which the elastic property and hydraulic conductivity images were recovered. Pressure field and material property estimates had spatial distributions reflecting their true counterparts in the phantom geometry with RMS errors around 20% for cases with 5% noise, but degraded significantly in both spatial distribution and property values for noise levels > 10%. When both shear moduli and hydraulic conductivity were estimated along with the pressure field, property value error rates were as high as 58%, 85% and 32% for the three quantities, respectively, and their spatial distributions were more distorted. Opportunities for improving the algorithm are discussed.

  3. The role of the Mre11–Rad50–Nbs1 complex in double-strand break repair—facts and myths

    International Nuclear Information System (INIS)

    Takeda, Shunichi; Hoa, Nguyen Ngoc; Sasanuma, Hiroyuki

    2016-01-01

    Homologous recombination (HR) initiates double-strand break (DSB) repair by digesting 5′-termini at DSBs, the biochemical reaction called DSB resection, during which DSBs are processed by nucleases to generate 3′ single-strand DNA. Rad51 recombinase polymerizes along resected DNA, and the resulting Rad51–DNA complex undergoes homology search. Although DSB resection by the Mre11 nuclease plays a critical role in HR in Saccharomyces cerevisiae, it remains elusive whether DSB resection by Mre11 significantly contributes to HR-dependent DSB repair in mammalian cells. Depletion of Mre11 decreases the efficiency of DSB resection only by 2- to 3-fold in mammalian cells. We show that although Mre11 is required for efficient HR-dependent repair of ionizing-radiation–induced DSBs, Mre11 is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines. Moreover, a 2- to 3-fold decrease in DSB resection has virtually no impact on the efficiency of HR. Thus, although a large number of researchers have reported the vital role of Mre11-mediated DSB resection in HR, the role may not explain the very severe defect in HR in Mre11-deficient cells, including their lethality. We here show experimental evidence for the additional roles of Mre11 in (i) elimination of chemical adducts from DSB ends for subsequent DSB repair, and (ii) maintaining HR intermediates for their proper resolution

  4. E3 Ligase cIAP2 Mediates Downregulation of MRE11 and Radiosensitization in Response to HDAC Inhibition in Bladder Cancer.

    Science.gov (United States)

    Nicholson, Judith; Jevons, Sarah J; Groselj, Blaz; Ellermann, Sophie; Konietzny, Rebecca; Kerr, Martin; Kessler, Benedikt M; Kiltie, Anne E

    2017-06-01

    The MRE11/RAD50/NBS1 (MRN) complex mediates DNA repair pathways, including double-strand breaks induced by radiotherapy. Meiotic recombination 11 homolog (MRE11) is downregulated by histone deacetylase inhibition (HDACi), resulting in reduced levels of DNA repair in bladder cancer cells and radiosensitization. In this study, we show that the mechanism of this downregulation is posttranslational and identify a C-terminally truncated MRE11, which is formed after HDAC inhibition as full-length MRE11 is downregulated. Truncated MRE11 was stabilized by proteasome inhibition, exhibited a decreased half-life after treatment with panobinostat, and therefore represents a newly identified intermediate induced and degraded in response to HDAC inhibition. The E3 ligase cellular inhibitor of apoptosis protein 2 (cIAP2) was upregulated in response to HDAC inhibition and was validated as a new MRE11 binding partner whose upregulation had similar effects to HDAC inhibition. cIAP2 overexpression resulted in downregulation and altered ubiquitination patterns of MRE11 and mediated radiosensitization in response to HDAC inhibition. These results highlight cIAP2 as a player in the DNA damage response as a posttranscriptional regulator of MRE11 and identify cIAP2 as a potential target for biomarker discovery or chemoradiation strategies in bladder cancer. Cancer Res; 77(11); 3027-39. ©2017 AACR . ©2017 American Association for Cancer Research.

  5. The North Atlantic marine reservoir effect in the Early Holocene: Implications for defining and understanding MRE values

    Energy Technology Data Exchange (ETDEWEB)

    Ascough, P.L. [School of Geography and Geosciences, Irvine Building, University of St. Andrews, St. Andrews, Fife KY16 9AL (United Kingdom)]. E-mail: pla1@st-andrews.ac.uk; Cook, G.T. [Scottish Universities Environmental Research Centre, Scottish Enterprise Technology Park, Rankine Avenue, East Kilbride G75 OQF (United Kingdom); Dugmore, A.J. [Institute of Geography, School of GeoSciences, University of Edinburgh, Edinburgh EH8 9XP (United Kingdom); Scott, E.M. [Department of Statistics, University of Glasgow, Glasgow G12 8QQ (United Kingdom)

    2007-06-15

    The marine reservoir effect (MRE) is a {sup 14}C age offset between the oceanic and atmospheric carbon reservoirs. The MRE is neither spatially nor temporally constant and values may deviate significantly from the global model average provided by the Marine04 curve. Such a deviation is calculated as a {delta}R value and modern (pre-bomb) values show considerable spatial variations. There is also considerable evidence for temporal variability linked to paleoenvironmental changes identified in paleoclimatic proxy records. Seven new {delta}R values are presented for the North Atlantic, relating to the period c. 8430-3890 cal. BP (c. 6480-1940 BC). These were obtained from {sup 14}C analysis of multiple samples of terrestrial and marine material derived from seven individual archaeological deposits from Mainland Scotland, the Outer Hebrides and the Orkney Isles. The {delta}R values vary between 143 {+-} 20 {sup 14}C yr and -100 {+-} 15 {sup 14}C yr with the positive values all occurring in the earlier period (8430-5060 cal. BP), and the negative values all coming from later deposits (4820-3890 cal. BP). The nature of MRE values and the potential for spatial and temporal variation in values is the subject of current research interest and these data are placed in the context of (i) other estimates for UK coastal waters and (ii) important questions concerning current approaches to quantifying the MRE.

  6. Realizacija računarske mreže vojnomedicinske akademije / Medical military academy information system management

    Directory of Open Access Journals (Sweden)

    Miroslav Stojanović

    2005-01-01

    Full Text Available Vojnomedicinska akademija (VMA u Beogradu danas se ne može zamisliti bez kvalitetnog informacionog sistema, koji se najčešće razvija u sistemu računarske mreže. Cilj ovoga rada je da prikaže smernice i definiše neka rešenja u implementaciji buduće računarske mreže VMA. Težište rada je na implementaciji prva tri nivoa OSI modela jedne složene i kompleksne mreže kakva bi trebalo da bude računarska mreža VMA. / The Medical Military Academy (MMA in Belgrade cannot be imagined without a high-quality information system implemented in a corresponding computer network. The aim of this study is to show guidelines and possible solutions in implementing a computer network in to the MMA in the future. The main part of this study describes the implementation of the first three levels of the OSI model into the complex MMA computer network.

  7. Mimivirus reveals Mre11/Rad50 fusion proteins with a sporadic distribution in eukaryotes, bacteria, viruses and plasmids.

    Science.gov (United States)

    Yoshida, Takashi; Claverie, Jean-Michel; Ogata, Hiroyuki

    2011-09-07

    The Mre11/Rad50 complex and the homologous SbcD/SbcC complex in bacteria play crucial roles in the metabolism of DNA double-strand breaks, including DNA repair, genome replication, homologous recombination and non-homologous end-joining in cellular life forms and viruses. Here we investigated the amino acid sequence of the Mimivirus R555 gene product, originally annotated as a Rad50 homolog, and later shown to have close homologs in marine microbial metagenomes. Our bioinformatics analysis revealed that R555 protein sequence is constituted from the fusion of an N-terminal Mre11-like domain with a C-terminal Rad50-like domain. A systematic database search revealed twelve additional cases of Mre11/Rad50 (or SbcD/SbcC) fusions in a wide variety of unrelated organisms including unicellular and multicellular eukaryotes, the megaplasmid of a bacterium associated to deep-sea hydrothermal vents (Deferribacter desulfuricans) and the plasmid of Clostridium kluyveri. We also showed that R555 homologs are abundant in the metagenomes from different aquatic environments and that they most likely belong to aquatic viruses. The observed phyletic distribution of these fusion proteins suggests their recurrent creation and lateral gene transfers across organisms. The existence of the fused version of protein sequences is consistent with known functional interactions between Mre11 and Rad50, and the gene fusion probably enhanced the opportunity for lateral transfer. The abundance of the Mre11/Rad50 fusion genes in viral metagenomes and their sporadic phyletic distribution in cellular organisms suggest that viruses, plasmids and transposons played a crucial role in the formation of the fusion proteins and their propagation into cellular genomes.

  8. Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer.

    Science.gov (United States)

    Brandt, Simone; Samartzis, Eleftherios P; Zimmermann, Anne-Katrin; Fink, Daniel; Moch, Holger; Noske, Aurelia; Dedes, Konstantin J

    2017-01-10

    BRCA1/2-deficient ovarian carcinomas are recognized as target for Poly (ADP-ribose) polymerase (PARP) inhibitors. BRCA1 and BRCA2 proteins are involved in homologous recombination repair of double-strand DNA breaks. The relevance of other homologous recombination repair proteins, e.g. MRE11, RAD50, NBS1 (MRN complex) in ovarian carcinomas is unclear. The objective of this study was to investigate the prevalence of lack of MRE11, RAD50, NBS1 protein detection in epithelial ovarian cancer (EOC). A tissue microarray (TMA) with 134 EOC was immunohistochemically evaluated for MRE11, RAD50 and NBS1. Data was analysed for associations with clinicopathological parameters, histological subtype, patient overall survival and mismatch repair (MMR) protein status. Sensitivity towards the PARP inhibitor BMN673 was tested in two ovarian cancer cell lines (TOV-21 and OVTOKO) using colony formation assays. Lack of MRN complex protein detection was seen in 41% (55/134) of EOC and was more frequent in low-grade (57.6%; 19/33) than in high-grade EOC (18.8%; 36/101; n = 134; p = 0.04). There was an association with the ovarian carcinoma subtype (60.3%; 35/58 lack of detection in type I versus 26.3%; 20/76 in type II; n = 134; p lack of MRE11, RAD50, NBS1 protein detection in type I human ovarian carcinomas is observed in EOC and our data suggests further investigation regarding sensitivity to PARP-inhibition in tumours lacking MRE11 expression.

  9. Mimivirus reveals Mre11/Rad50 fusion proteins with a sporadic distribution in eukaryotes, bacteria, viruses and plasmids

    Directory of Open Access Journals (Sweden)

    Ogata Hiroyuki

    2011-09-01

    Full Text Available Abstract Background The Mre11/Rad50 complex and the homologous SbcD/SbcC complex in bacteria play crucial roles in the metabolism of DNA double-strand breaks, including DNA repair, genome replication, homologous recombination and non-homologous end-joining in cellular life forms and viruses. Here we investigated the amino acid sequence of the Mimivirus R555 gene product, originally annotated as a Rad50 homolog, and later shown to have close homologs in marine microbial metagenomes. Results Our bioinformatics analysis revealed that R555 protein sequence is constituted from the fusion of an N-terminal Mre11-like domain with a C-terminal Rad50-like domain. A systematic database search revealed twelve additional cases of Mre11/Rad50 (or SbcD/SbcC fusions in a wide variety of unrelated organisms including unicellular and multicellular eukaryotes, the megaplasmid of a bacterium associated to deep-sea hydrothermal vents (Deferribacter desulfuricans and the plasmid of Clostridium kluyveri. We also showed that R555 homologs are abundant in the metagenomes from different aquatic environments and that they most likely belong to aquatic viruses. The observed phyletic distribution of these fusion proteins suggests their recurrent creation and lateral gene transfers across organisms. Conclusions The existence of the fused version of protein sequences is consistent with known functional interactions between Mre11 and Rad50, and the gene fusion probably enhanced the opportunity for lateral transfer. The abundance of the Mre11/Rad50 fusion genes in viral metagenomes and their sporadic phyletic distribution in cellular organisms suggest that viruses, plasmids and transposons played a crucial role in the formation of the fusion proteins and their propagation into cellular genomes.

  10. Preslikavanje parametara kvaliteta usluga na protokole ATM mreža / Quality of service mapping to ATM network protocols

    Directory of Open Access Journals (Sweden)

    Milojko Jevtović

    2005-11-01

    Full Text Available Preslikavanje parametara kvaliteta usluga (Quality of Service - QoS jedan je od bitnih elemenata u koncepciji ATM (Asynchronous Transfer Mode širokopojasnih mreža. U radu su opisani parametri QoS-a (verovatnoće pogrešnih ramova i ćelija, propusni opseg, kašnjenje ćelija, varijacija kašnjenja koji se preslikavaju na protokole ATM mreža. Preslikavanje se izvodi između korisničkog i aplikacionog QoS-a, a aplikacioni QoS se preslikava na QoS prenosa i komutacije, odnosno na ATM protokole, tzv. protokole ATM adaptacionog sloja i, konačno, preslikava se (mapira na ATM mrežne performanse (ATM sloj. Analiza procesa preslikavanja parametara kvaliteta usluga značajna je sa stanovišta korisnika usluga ATM mreža pri izboru klasa usluga koje će koristiti u komunikaciji preko date ATM mreže. / Quality of service mapping is one of the crucial elements in ATM concept of wide networks. In this paper QoS parameters mapping to ATM network protocols are described. Mapping is made between QoS user and QoS application, and application QoS is mapped to QoS transfer and commutation i.e. to ATM protocols - ATM adaptation layer protocols and finally it is mapped to ATM network performances. Analysis of this QoS mapping parameters process is very important for ATM users when they are choosing classes of service that can be used in communication process through ATM network.

  11. Mre11 Deficiency in Arabidopsis Is Associated with Chromosomal Instability in Somatic Cells and Spo11-Dependent Genome Fragmentation during Meiosis

    Science.gov (United States)

    Puizina, Jasna; Siroky, Jiri; Mokros, Petr; Schweizer, Dieter; Riha, Karel

    2004-01-01

    The Mre11/Rad50/Nbs1 complex is involved in many aspects of chromosome metabolism. Aberrant function of the complex is associated with defects in the DNA checkpoint, double-strand break repair, meiosis, and telomere maintenance. In this article, we report the consequences of Mre11 dysfunction for the stability of mitotic and meiotic chromosomes in Arabidopsis thaliana. Although plants homozygous for a T-DNA insertion in a conserved region of the MRE11 gene are viable, they exhibit growth defects and are infertile. Analysis of mitotic chromosomes prepared from the mutant plants revealed abundant dicentric chromosomes and chromosomal fragments. Fluorescence in situ hybridization showed that anaphase bridges are often formed by homologous chromosome arms. The frequency of chromosome fusions was not reduced in mre11 ku70 double mutants, suggesting that plants possess DNA end-joining activities independent of the Ku70/80 and Mre11 complexes. Cytogenetic examination of pollen mother cells revealed massive chromosome fragmentation and the absence of synapsis in the initial stages of meiosis. The fragmentation was substantially suppressed in mre11 spo11-1 double mutants, indicating that Mre11 is required for repair but not for the induction of Spo11-dependent meiotic DNA breaks in Arabidopsis. PMID:15258261

  12. In silico characterization and Molecular modeling of double-strand break repair protein MRE11 from Phoenix dactylifera v deglet nour.

    Science.gov (United States)

    Rekik, Imen; Chaabene, Zayneb; Grubb, C Douglas; Drira, Noureddine; Cheour, Foued; Elleuch, Amine

    2015-11-05

    DNA double-strand breaks (DSBs) are highly cytotoxic and mutagenic. MRE11 plays an essential role in repairing DNA by cleaving broken ends through its 3' to 5' exonuclease and single-stranded DNA endonuclease activities. The present study aimed to in silico characterization and molecular modeling of MRE11 from Phoenix dactylifera L cv deglet nour (DnMRE11) by various bioinformatic approaches. To identify DnMRE11 cDNA, assembled contigs from our cDNA libraries were analysed using the Blast2GO2.8 program. The DnMRE11 protein length was 726 amino acids. The results of HUMMER show that DnMRE11 is formed by three domains: the N-terminal core domain containing the nuclease and capping domains, the C-terminal half containing the DNA binding and coiled coil region. The structure of DnMRE11 is predicted using the Swiss-Model server, which contains the nuclease and capping domains. The obtained model was verified with the structure validation programs such as ProSA and QMEAN servers for reliability. Ligand binding studies using COACH indicated the interaction of DnMRE11 protein with two Mn(2+) ions and dAMP. The ConSurf server predicted that residues of the active site and Nbs binding site have high conservation scores between plant species. A model structure of DnMRE11 was constructed and validated with various bioinformatics programs which suggested the predicted model to be satisfactory. Further validation studies were conducted by COACH analysis for active site ligand prediction, and revealed the presence of six ligands binding sites and two ligands (2 Mn(2+) and dAMP).

  13. Bezbednost i zaštita telekomunikacionih širokopojasnih ATM mreža / Security and protection in the broadband ATM telecommunication networks

    Directory of Open Access Journals (Sweden)

    Milojko V. Jevtović

    2009-10-01

    Full Text Available U radu je prikazana analiza problema bezbednosti i zaštite telekomunikacionih širokopojasnih ATM mreža. Analizirane su brojne moguće pretnje i oblici ugrožavanja širokopojasnih mreža i navedeni zahtevi za bezbednost i zaštitu mreža. Obrađena je koncepcija bezbednosnih mehanizama. Analizirane su bezbednosne mrežne usluge i opisan bezbednosni model ATM mreža. Navedeni su problemi koji se javljaju pri realizaciji bezbednosnih mera i zaštite u komunikaciji preko ATM mreža. / Security of communications over broadband ATM networks is analyzed in this paper. Attacks on ATM networks (faber tapping, SONET (Synchronous Optical network drop/add multiplexor attacks, eavesdropping, spoofing, virtual channel stealing, service denial, traffic analysis, protocol weaknesses, ILMI (Integrated Local Management Interface attacks, PNNI (Private Network to Network Interface attacks, model of ATM and ATM security framework are described. Some problems occurring within security and protection realization in the communication over ATM networks are also specified.

  14. Experimental and Analytical Research on Resonance Phenomena of Vibrating Head with MRE Regulating Element

    Science.gov (United States)

    Miedzińska, D.; Gieleta, R.; Osiński, J.

    2015-02-01

    A vibratory pile hammer (VPH) is a mechanical device used to drive steel piles as well as tube piles into soil to provide foundation support for buildings or other structures. In order to increase the stability and the efficiency of the VPH work in the over-resonance frequency, a new VPH construction was developed at the Military University of Technology. The new VPH contains a system of counter-rotating eccentric weights, powered by hydraulic motors, and designed in such a way that horizontal vibrations cancel out, while vertical vibrations are transmitted into the pile. This system is suspended in the static parts by the adaptive variable stiffness pillows based on a smart material, magnetorheological elastomer (MRE), whose rheological and mechanical properties can be reversibly and rapidly controlled by an external magnetic field. The work presented in the paper is a part of the modified VPH construction design process. It concerns the experimental research on the vibrations during the piling process and the analytical analyses of the gained signal. The results will be applied in the VPH control system.

  15. Drivers and Effects of Groundwater-Surface Water Interaction in the Karstic Lower Flint River Basin, Southwestern Georgia, USA

    Science.gov (United States)

    Rugel, K.; Golladay, S. W.; Jackson, C. R.; Rasmussen, T. C.; Dowd, J. F.; Mcdowell, R. J.

    2017-12-01

    Groundwater provides the majority of global water resources for domestic and agricultural usage while contributing vital surface water baseflows which support healthy aquatic ecosystems. Understanding the extent and magnitude of hydrologic connectivity between groundwater and surface water components in karst watersheds is essential to the prudent management of these hydraulically-interactive systems. We examined groundwater and surface water connectivity between the Upper Floridan Aquifer (UFA) and streams in the Lower Flint River Basin (LFRB) in southwestern Georgia where development of agricultural irrigation intensified over the past 30 years. An analysis of USGS streamflow data for the pre- and post-irrigation period showed summer baseflows in some Lower Flint River tributaries were reduced by an order of magnitude in the post-irrigation period, reiterating the strong hydraulic connection between these streams and the underlying aquifer. Large and fine-scale monitoring of calcium, nitrate, specific conductance and stable isotopes (δ18O and δD) on 50 km of Ichawaynochaway Creek, a major tributary of the Lower Flint, detected discrete groundwater-surface water flow paths which accounted for 42% of total groundwater contributions in the 50 km study reach. This presentation will highlight a new analysis using the metadata EPA Reach File (1) and comparing stream reach and instream bedrock joint azimuths with stream geochemical results from previous field study. Our findings suggested that reaches with NNW bearing may be more likely to display enhanced groundwater-surface water connectivity. Our results show that local heterogeneity can significantly affect water budgets and quality within these watersheds, making the use of geomorphological stream attributes a valuable tool to water resource management for the prediction and protection of vulnerable regions of hydrologic connectivity in karst catchments.

  16. Modelling hydrological changes in surface in relation with anthropogenic drivers and consequences on human health and local economic

    Science.gov (United States)

    Sandoz, Alain; Leblond, Agnès; Boutron, Olivier

    2016-04-01

    of the watershed. The modeling also performed to simulate a change in rainfall locally to measure hydrological and environmental consequences. According to these scenarios, it was possible to map the potential areas of mosquitoes breeding sites (presence / absence of mosquitoes) and their impact on urban populations in terms of health risks and nuisance. This territory represents many interests for decision-makers interested in issues of governance and renaturation. To improve the inclusion of better water governance and territories, as well as facilitate dynamic annealing, it might be necessary to help decision-makers having a better knowledge of the impact of human drivers on water management on the territory. This increased knowledge would also enable local decision-makers to improve their awareness of the heritage and biodiversity of wetlands. This project was funded by the French Ministry of Ecology, Sustainable Development and Energy as part of the projects Water and Territories.

  17. Patterns and Drivers of Vertical Distribution of the Ciliate Community from the Surface to the Abyssopelagic Zone in the Western Pacific Ocean.

    Science.gov (United States)

    Zhao, Feng; Filker, Sabine; Xu, Kuidong; Huang, Pingping; Zheng, Shan

    2017-01-01

    The deep sea is one of the largest but least understood ecosystems on earth. Knowledge about the diversity and distribution patterns as well as drivers of microbial eukaryote (including ciliates) along the water column, particularly below the photic zone, is scarce. In this study, we investigated the diversity of pelagic ciliates, the main group of marine microeukaryotes, their vertical distribution from the surface to the abyssopelagic zone, as well as their horizontal distribution over a distance of 1,300 km in the Western Pacific Ocean, using high-throughput DNA and cDNA (complementary DNA) sequencing. No distance-decay relationship could be detected along the horizontal scale; instead, a distinct vertical distribution within the ciliate communities was revealed. The alpha diversity of the ciliate communities in the deep chlorophyll maximum (DCM) and the 200 m layer turned out to be significantly higher compared with the other water layers. The ciliate communities in the 200 m water layer appeared to be more similar to those in deeper layers from 1,000 m to about 5,000 m than to the surface and DCM ciliate communities. Dominant species in the bathypelagic and abyssopelagic zone, particularly some parasites, were also detected in the 200 m layer, but were almost absent in the surface layer. The 200 m layer, therefore, seems to be an important "species bank" for deep ocean layers. Statistical analyses further revealed significant effects of temperature and chlorophyll a on the partitioning of ciliate diversity, indicating that environmental factors are a stronger force in shaping marine pelagic ciliate communities than the geographic distance.

  18. A theory for narrow-banded radio bursts at Uranus - MHD surface waves as an energy driver

    Science.gov (United States)

    Farrell, W. M.; Curtis, S. A.; Desch, M. D.; Lepping, R. P.

    1992-01-01

    A possible scenario for the generation of the narrow-banded radio bursts detected at Uranus by the Voyager 2 planetary radio astronomy experiment is described. In order to account for the emission burstiness which occurs on time scales of hundreds of milliseconds, it is proposed that ULF magnetic surface turbulence generated at the frontside magnetopause propagates down the open/closed field line boundary and mode-converts to kinetic Alfven waves (KAW) deep within the polar cusp. The oscillating KAW potentials then drive a transient electron stream that creates the bursty radio emission. To substantiate these ideas, Voyager 2 magnetometer measurements of enhanced ULF magnetic activity at the frontside magnetopause are shown. It is demonstrated analytically that such magnetic turbulence should mode-convert deep in the cusp at a radial distance of 3 RU.

  19. [Results of the introduction of the "mre Netzwerk Nordwest" quality certification for nursing homes in Bonn].

    Science.gov (United States)

    Braubach, A; Scherholz-Schlösser, G; Thole, S; Daniels-Haardt, I; Heyer, I

    2014-04-01

    The Commission for Hospital Hygiene and Infection Prevention of the Robert Koch Institute (KRINKO) published a Recommendation for Prevention of Infection in Nursing Homes in 2005 [Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut (KRINKO)]. The recommended measures for infection control of multidrug-resistant pathogens (MRP) are well known in most institutions. The "mre-Netzwerk Nordwest" quality certification is new, and was implemented by the KRINKO recommendation on a standardized basis for the first time in 2012 in Bonn, Germany. This study describes the first results of this initiative. The certification contains guidelines based on the above-mentioned KRINKO recommendation and a survey on the status of infections and antibiotic therapies. Nursing homes in Bonn were asked to fulfill a list of ten criteria. The process was supervised by the local health authority and evaluated. Of 38 nursing homes in Bonn, 19 acquired the certification. The survey showed that 1.4% of the residents were treated with antibiotics. Four pathogens were identified as MRP, but did not belong to the classic spectrum. In all, 42% of infections were treated with beta-lactams and 8% with quinolones. The evaluation showed that at least ten urinary tract catheters were removed because of the certification and a related re-evaluation of the indication was made by the treating physician. Implementation of the certification was assessed as positive, although it involves additional investments. The application of the approach was considered feasible as compared with other regions. The portion of antibiotic therapy use and partly that of other drugs was comparable to the findings of Wischnewski et al., Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 54(11):1147-1152, 2011. Re-assessing the indication for urinary tract catheters might have a positive influence on the prevention of infections. The certification can trigger the exchange of

  20. Tradeoffs of vertical-cavity surface emitting lasers modeling for the development of driver circuits in short distance optical links

    Science.gov (United States)

    Sialm, Gion; Erni, Daniel; Vez, Dominique; Kromer, Christian; Ellinger, Frank; Bona, Gian-Luca; Morf, Thomas; Jäckel, Heinz

    2005-10-01

    In short-distance optical links, the development of driving circuits for vertical-cavity surface-emitting lasers (VCSELs) requires precise and computationally efficient VCSEL models. A small-signal model of a VCSEL is computationally efficient and simple to implement; however, it does not take into account the nonlinear output behavior of the VCSEL. In contrast, VCSEL models that are highly based on first principles cannot be implemented in standard circuit device simulators, because the simulation of eye diagrams becomes too time consuming. We present another approach using VCSEL models, which are based on the 1-D rate equations. Our analysis shows that they combine efficient extraction and short simulation time with an accurate calculation of eye diagrams over a wide range of ambient temperatures. As different implementations of the rate equations exist, tradeoffs between three different versions are presented and compared with measured GaAs oxide-confined VCSELs. The first model has a linear and the second a logarithmic function of the gain versus the carrier density. The third model considers the additional transport time for carriers to reach the active region with quantum wells. For parameter extraction, a minimum set of parameters is identified, which can be determined from fundamental measurements.

  1. Virtuelne privatne mreže - moguće rešenje pouzdanih komunikacija / Virtual private networks: Possible solution of reliable communications

    Directory of Open Access Journals (Sweden)

    Marinko Smiljanić

    2008-04-01

    Full Text Available U radu su prikazane osnovne karakteristike virtuelnih privatnih mreža (VPN - Virtual Private Networks. Analizirane su VPN mreže na drugom i trećem sloju sistema otvorenog za povezivanje (OSI - Open System Interconnection. Objašnjena je realizacija internet protokola (IP - Internet Protocol VPN mreže i VPN mreže u okruženju višestruke komutacije labela (MPLS - Multi-Protocol Label Switching. Posebna pažnja posvećena je sigurnosti MPLS VPN mreža, naročito sa stanovišta upotrebe u funkcionalnim sistemima veza, kao što je sistem veza Vojske. / In this paper the basic characteristics of the VPN networks are presented. The VPN networks on the second and the third level of the OSI reference model are analyzed. The realization of the IP VPN and VPN networks within MPLS environment is presented as well. Security in MPLS networks is one of the most important characteristics, especially in military communication systems, which is shown in the second part of this paper.

  2. Simulacija rada optičke mreže pomoću simulatora ns-2 / Simulation of optical network operation using simulator ns-2

    Directory of Open Access Journals (Sweden)

    Milovan Kostadinović-Dišović

    2007-04-01

    Full Text Available Optički multipleks zasnovan na talasnoj dužini nosioca OWDM1 je tehnologija mreža identifikovana kao odgovarajuća buduća širokopojasna mrežna okruženja sa dokazanim mogućnostima u pogledu odgovora na povećane zahteve navedenih mreža i kratkom vremenu za uspostavljanje komunikacija. Buduće optičke širokopojasne mreže OWAN2 zahtevaju stvaranje odgovarajućih mrežnih protokola i algoritama koji treba da odgovore na promenljive operativne zahteve. / Optical wavelength division multiplexing (WDM3 networking technology has been identified as a suitable candidate for future wide area network (WAN4 environments, due to its potential ability to meet rising demands of high bandwidth and low latency communication. Networking protocols and algorithms are being developed to meet the changing operational requirements in future optical WANs (OWAN.

  3. Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI+ cells and tumors containing a mutation of MRE11

    DEFF Research Database (Denmark)

    Rodriguez, Rene; Hansen, Lasse Tengbjerg; Phear, Geraldine

    2008-01-01

    PURPOSE: DNA synthesis inhibitors and damaging agents are widely used in cancer therapy; however, sensitivity of tumors to such agents is highly variable. The response of tumor cells in culture to these agents is strongly influenced by the status of DNA damage response pathways. Here, we attempt...... is not a direct result of MMR, p53, or p21 status. However MMR-deficient cell lines containing an intronic frameshift mutation of MRE11 show greatest sensitivity to these agents. Increased sensitivity to this combination is also evident in vivo as thymidine enhances irinotecan-induced growth suppression of MMR......-deficient tumors carrying the MRE11 mutation in mouse xenografts. CONCLUSION: Irinotecan-thymidine combinations may be particularly effective when targeted to MSI+ tumors containing this readily detectable MRE11 mutation....

  4. Analiza protokola kvaliteta usluga telekomunikacionih mreža / Analysis of quality of service protocols in telecommunication networks

    Directory of Open Access Journals (Sweden)

    Milojko Jevtović

    2003-05-01

    Full Text Available Protokoli kvaliteta usluga (Quality of Service - QoS sadašnjih i budućih telekomunikacionih mreža razvijeni su, pored ostalog, sa ciljem da podrže različite klase usluga (Class of Service - CoS komunikaciju u realnom vremenu, kao i prenos multimedijalnih poruka preko paketskih IP (Internet Protocol mreža. U raduje dat pregled karakteristika tih protokola i ocena njihovih konkretnih mogućnosti u obezbeđenju kvaliteta usluga unutar sistema ('s vrha do dna', tj. vertikalno u OSI arhitekturi kao i 'horizontalno' odnosno s kraja na kraj veze, tj. između izvora i odredišta. / Today's and future telecommunication networks must enable transmission throughout heterogeneous environment, using different Quality of Service protocols, Quality of Service protocols use a variety of complementary mechanisms to enable deterministic end-to-end different data delivery. The analysis of these protocols and their efficiency in providing QoS and CoS has been given in this paper.

  5. Primerjava fizikalnih modelov Adblue tekočine pri SCR sistemih ter vpliv mrež različnih gostot

    OpenAIRE

    Milošič, Teo

    2013-01-01

    Diplomska naloga predstavlja primerjavo fizikalnih modelov Adblue tekočine pri SCR sistemih. AdBlue tekočina je enkrat obravnavana kot več-komponentna zmes (vodna raztopina uree – UWS), drugič kot eno-komponentna zmes (voda), primerjava pa je pokazala vpliv izbire modela na rezultate CFD simulacije. Izvedena je bila tudi primerjava računskih mrež različnih gostot in s tem predstavljen vpliv velikosti celice računske mreže na rezultate. Simulacije in analize so bile narejene s programskim pake...

  6. Assessment of in vivo laser ablation using MR elastography with an inertial driver.

    Science.gov (United States)

    Chen, Jun; Woodrum, David A; Glaser, Kevin J; Murphy, Matthew C; Gorny, Krzysztof; Ehman, Richard

    2014-07-01

    To evaluate the feasibility of using MR Elastography (MRE) to monitor tissue coagulation extent during in vivo percutaneous laser ablation of the liver. A novel inertial acoustic driver was developed to apply mechanical waves via the ablation instrument. Ablation testing was performed in live juvenile female pigs under anesthesia in a 1.5-T whole-body MRI scanner. The inertial driver produced suitable mechanical wave fields in the liver before, during, and after the laser ablation. During 2-min ablations using 4.5-, 7.5- and 15-W laser power, the stiffness of the lesions changed substantially in response to laser heating, indicative of protein denaturation. After a lethal thermal dose (2-min, 15-W) ablation, lesion stiffness was significantly greater than the baseline values (P W) ablations (64.4% vs. 22.5%, P = 0.009). MRE was shown capable of measuring tissue stiffness changes due to in vivo laser ablation. If confirmed through additional studies, this technology may be useful in clinical tumor ablation to monitor the spatial extent of tissue coagulation. Copyright © 2013 Wiley Periodicals, Inc.

  7. MRE11-deficiency associated with improved long-term disease free survival and overall survival in a subset of stage III colon cancer patients in randomized CALGB 89803 trial.

    Directory of Open Access Journals (Sweden)

    Thomas Pavelitz

    Full Text Available Colon cancers deficient in mismatch repair (MMR may exhibit diminished expression of the DNA repair gene, MRE11, as a consequence of contraction of a T11 mononucleotide tract. This study investigated MRE11 status and its association with prognosis, survival and drug response in patients with stage III colon cancer.Cancer and Leukemia Group B 89803 (Alliance randomly assigned 1,264 patients with stage III colon cancer to postoperative weekly adjuvant bolus 5-fluorouracil/leucovorin (FU/LV or irinotecan+FU/LV (IFL, with 8 year follow-up. Tumors from these patients were analyzed to determine stability of a T11 tract in the MRE11 gene. The primary endpoint was overall survival (OS, and a secondary endpoint was disease-free survival (DFS. Non-proportional hazards were addressed using time-dependent covariates in Cox analyses.Of 625 tumor cases examined, 70 (11.2% exhibited contraction at the T11 tract in one or both MRE11 alleles and were thus predicted to be deficient in MRE11 (dMRE11. In pooled treatment analyses, dMRE11 patients showed initially reduced DFS and OS but improved long-term DFS and OS compared with patients with an intact MRE11 T11 tract. In the subgroup of dMRE11 patients treated with IFL, an unexplained early increase in mortality but better long-term DFS than IFL-treated pMRE11 patients was observed.Analysis of this relatively small number of patients and events showed that the dMRE11 marker predicts better prognosis independent of treatment in the long-term. In subgroup analyses, dMRE11 patients treated with irinotecan exhibited unexplained short-term mortality. MRE11 status is readily assayed and may therefore prove to be a useful prognostic marker, provided that the results reported here for a relatively small number of patients can be generalized in independent analyses of larger numbers of samples.ClinicalTrials.gov NCT00003835.

  8. Mre11 and Blm-Dependent Formation of ALT-Like Telomeres in Ku-Deficient Ustilago maydis.

    Directory of Open Access Journals (Sweden)

    Eun Young Yu

    2015-10-01

    Full Text Available A subset of human cancer cells uses a specialized, aberrant recombination pathway known as ALT to maintain telomeres, which in these cells are characterized by complex aberrations including length heterogeneity, high levels of unpaired C-strand, and accumulation of extra-chromosomal telomere repeats (ECTR. These phenotypes have not been recapitulated in any standard budding or fission yeast mutant. We found that eliminating Ku70 or Ku80 in the yeast-like fungus Ustilago maydis results initially in all the characteristic telomere aberrations of ALT cancer cells, including C-circles, a highly specific marker of ALT. Subsequently the ku mutants experience permanent G2 cell cycle arrest, accompanied by loss of telomere repeats from chromosome ends and even more drastic accumulation of very short ECTRs (vsECTRs. The deletion of atr1 or chk1 rescued the lethality of the ku mutant, and "trapped" the telomere aberrations in the early ALT-like stage. Telomere abnormalities are telomerase-independent, but dramatically suppressed by deletion of mre11 or blm, suggesting major roles for these factors in the induction of the ALT pathway. In contrast, removal of other DNA damage response and repair factors such as Rad51 has disparate effects on the ALT phenotypes, suggesting that these factors process ALT intermediates or products. Notably, the antagonism of Ku and Mre11 in the induction of ALT is reminiscent of their roles in DSB resection, in which Blm is also known to play a key role. We suggest that an aberrant resection reaction may constitute an early trigger for ALT telomeres, and that the outcomes of ALT are distinct from DSB because of the unique telomere nucleoprotein structure.

  9. Mre11 and Blm-Dependent Formation of ALT-Like Telomeres in Ku-Deficient Ustilago maydis.

    Science.gov (United States)

    Yu, Eun Young; Pérez-Martín, José; Holloman, William K; Lue, Neal F

    2015-10-01

    A subset of human cancer cells uses a specialized, aberrant recombination pathway known as ALT to maintain telomeres, which in these cells are characterized by complex aberrations including length heterogeneity, high levels of unpaired C-strand, and accumulation of extra-chromosomal telomere repeats (ECTR). These phenotypes have not been recapitulated in any standard budding or fission yeast mutant. We found that eliminating Ku70 or Ku80 in the yeast-like fungus Ustilago maydis results initially in all the characteristic telomere aberrations of ALT cancer cells, including C-circles, a highly specific marker of ALT. Subsequently the ku mutants experience permanent G2 cell cycle arrest, accompanied by loss of telomere repeats from chromosome ends and even more drastic accumulation of very short ECTRs (vsECTRs). The deletion of atr1 or chk1 rescued the lethality of the ku mutant, and "trapped" the telomere aberrations in the early ALT-like stage. Telomere abnormalities are telomerase-independent, but dramatically suppressed by deletion of mre11 or blm, suggesting major roles for these factors in the induction of the ALT pathway. In contrast, removal of other DNA damage response and repair factors such as Rad51 has disparate effects on the ALT phenotypes, suggesting that these factors process ALT intermediates or products. Notably, the antagonism of Ku and Mre11 in the induction of ALT is reminiscent of their roles in DSB resection, in which Blm is also known to play a key role. We suggest that an aberrant resection reaction may constitute an early trigger for ALT telomeres, and that the outcomes of ALT are distinct from DSB because of the unique telomere nucleoprotein structure.

  10. Examination of Supplemental Driver Training and Online Basic Driver Education

    Science.gov (United States)

    2012-06-01

    This report describes supplemental driver training programs and online basic driver education. It coves supplemental driver training that : focused on knowledge and skills beyond those normally found in traditional driver education delivered in the U...

  11. Online driver's license renewal.

    Science.gov (United States)

    2015-09-01

    The Kentucky Department of Vehicle Regulation is exploring the possibility of developing and implementing online : drivers license renewal. The objective of this project was to: 1) evaluate online drivers license and REAL ID renewal : programs ...

  12. Technology and teen drivers.

    Science.gov (United States)

    Lee, John D

    2007-01-01

    The rapid evolution of computing, communication, and sensor technology is likely to affect young drivers more than others. The distraction potential of infotainment technology stresses the same vulnerabilities that already lead young drivers to crash more frequently than other drivers. Cell phones, text messaging, MP3 players, and other nomadic devices all present a threat because young drivers may lack the spare attentional capacity for vehicle control and the ability to anticipate and manage hazards. Moreover, young drivers are likely to be the first and most aggressive users of new technology. Fortunately, emerging technology can also support safe driving. Electronic stability control, collision avoidance systems, intelligent speed adaptation, and vehicle tracking systems can all help mitigate the threats to young drivers. However, technology alone is unlikely to make young drivers safer. One promising approach to tailoring technology to teen drivers is to extend proven methods for enhancing young driver safety. The success of graduated drivers license programs (GDL) and the impressive safety benefit of supervised driving suggest ways of tailoring technology to the needs of young drivers. To anticipate the effects of technology on teen driving it may be useful to draw an analogy between the effects of passengers and the effects of technology. Technology can act as a teen passenger and undermine safety or it can act as an adult passenger and enhance safety. Rapidly developing technology may have particularly large effects on teen drivers. To maximize the positive effects and minimize the negative effects will require a broad range of industries to work together. Ideally, vehicle manufacturers would work with infotainment providers, insurance companies, and policy makers to craft new technologies so that they accommodate the needs of young drivers. Without such collaboration young drivers will face even greater challenges to their safety as new technologies emerge.

  13. Photodetachment of free hexahalogenometallate doubly charged anions in the gas phase: [ML6]2-, (M=Re, Os, Ir, Pt; L=Cl and Br)

    International Nuclear Information System (INIS)

    Wang, X.; Wang, L.

    1999-01-01

    We report the first observation and photodetachment photoelectron spectroscopic study of a series of hexahalogenometallates dianions MCl 6 2- (M=Re, Os, Ir, and Pt) and MBr 6 2- (M=Re, Ir, and Pt) in the gas phase. All of these species were found to be stable as free gaseous doubly charged anions. Photoelectron spectra of all the dianions were obtained at several detachment photon energies. The photon-energy-dependent spectra clearly revealed the dianion nature of these species and allowed the repulsive Coulomb barriers to be estimated. The binding energies of the second excess electron in MCl 6 2- (M=Re, Os, Ir, Pt) were determined to be 0.46 (5), 0.46 (5), 0.82 (5), and 1.58 (5) eV, respectively, and those in MBr 6 2- (M=Re, Ir, Pt) to be 0.76 (6), 0.96 (6), and 1.52 (6) eV, respectively. A wealth of electronic structure information about these metal complexes were obtained and low-lying and highly-excited electronic states of the corresponding singly charged anions were observed. Detachment from metal d orbitals or ligand orbitals were observed and could be clearly distinguished; detachments from the metal d-orbitals all occur at low binding energies whereas those from the ligand-dominated orbitals all take place at rather high binding energies. We also found a remarkable correlation between electron affinities measured in vacuo and the redox potentials obtained in the solution phase of these species. copyright 1999 American Institute of Physics

  14. Early diagnosis and severity assessment of acute pancreatitis (AP) using MR elastography (MRE) with spin-echo echo-planar imaging.

    Science.gov (United States)

    Shi, Yu; Liu, Ying; Liu, Yan-Qing; Gao, Feng; Li, Jia-Hui; Li, Qiu-Ju; Guo, Qi-Yong

    2017-11-01

    To evaluate the accuracy of magnetic resonance elastography (MRE) in comparison to contrast-enhanced computed tomography (CE-CT) for early diagnosis and prediction of severity in acute pancreatitis (AP). This cross-sectional prospective study included 76 patients with suspected AP who underwent both CE-CT and 3.0T MRE within 24 hours of hospital admission. Pancreatic stiffness, CT severity index (CTSI), Acute Physiology and Chronic Health Evaluation (APACHE)-II, and Bedside Index for Severity in AP (BISAP) scores were comparatively evaluated using data from the first 24 hours of admission, and diagnosis and severity of AP were confirmed according to the revised Atlanta Classification (2012). The accuracy of MRE for predicting disease severity was compared with that of CE-CT and the clinical scoring systems using area under the receiver-operating curve (AUC) analysis. AP was confirmed in 56/76 patients (73.7%). Pancreatic stiffness values of >1.47 kPa showed significantly better diagnostic performance than CE-CT (AUC: 0.993 vs. 0.818, P AP. The accuracy of pancreatic stiffness >2.47 kPa was comparable to that of the CTSI, APACHE-II and BISAP scores for predicting severe AP (accuracy = 85.5%, 75.0%, 88.2%, and 78.9%, respectively). The pairwise comparisons were not significant after Bonferroni correction (P AP. We recommend MRE at hospital admission for initial evaluation of AP. 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:1311-1319. © 2017 International Society for Magnetic Resonance in Medicine.

  15. Comparison of mass concentrations determined with personal respirable coal mine dust samplers operating at 1.2 liters per minute and the Casella 113A gravimetric sampler (MRE).

    Science.gov (United States)

    Treaftis, H N; Gero, A J; Kacsmar, P M; Tomb, T F

    1984-12-01

    Measuring respirable dust concentrations in coal mine environments is currently done using approved personal respirable dust sampling equipment operating at a flow rate of 2.0 liters per minute (Lpm). Measurements made with approved coal mine dust sampling equipment are converted to equivalent concentrations that would be obtained with a Mining Research Establishment (MRE) instrument known as the Casella 113A gravimetric sampler, using a conversion factor of 1.38. NIOSH has recently recommended that coal mine dust samplers (CMDS) used to measure respirable dust levels in mine environments be operated at 1.2 Lpm and measured concentrations be multiplied by 0.91 to obtain an equivalent MRE concentration. The purpose of this recommendation is to reduce systematic error caused by the variation in mine dust distributions. This paper presents and discusses data collected in the laboratory and in underground coal mines to evaluate the recommended 1.2 Lpm flow rate and 0.91 conversion factor. Comparative measurements were obtained in the laboratory with the CMDS operating at 2.0 and 1.2 liters per minute and the MRE, using aerosols of coal and limestone dust of varying particle size distribution. Similar comparative measurements were made in a number of underground coal mines at locations with environments having particle size distributions representative of different underground mining operations. It was concluded from this study that there is no significant change in the variability associated with the constant factor used to convert respirable dust measurements, obtained with approved respirable CMDS, to equivalent MRE measurements when the flow rate of the CMDS is reduced from 2.0 to 1.2 Lpm.

  16. Does tumorigenesis select for or against mutations of the DNA repair-associated genes BRCA2 and MRE11?: Considerations from somatic mutations in microsatellite unstable (MSI gastrointestinal cancers

    Directory of Open Access Journals (Sweden)

    Elghalbzouri-Maghrani Elhaam

    2006-01-01

    Full Text Available Abstract Background The BRCA2 and MRE11 proteins participate in the repair of double-strand DNA breaks by homologous recombination. Germline BRCA2 mutations predispose to ovarian, breast and pancreatic cancer, while a germline MRE11 mutation is associated with an ataxia telangiectasia-like disorder. Somatic mutations of BRCA2 are rare in typical sporadic cancers. In tumors having microsatellite instability (MSI, somatic truncating mutations in a poly [A] tract of BRCA2 are reported on occasion. Results We analyzed gastrointestinal MSI cancers by whole gene BRCA2 sequencing, finding heterozygous truncating mutations in seven (47% of 15 patients. There was no cellular functional defect in RAD51 focus-formation in three heterozygously mutated lines studied, although other potential functions of the BRCA2 protein could still be affected. A prior report of mutations in primary MSI tumors affecting the IVS5-(5–15 poly [T] tract of the MRE11 gene was confirmed and extended by analysis of the genomic sequence and protein expression in MSI cancer cell lines. Statistical analysis of the published MRE11 mutation rate in MSI tumors did not provide evidence for a selective pressure favoring biallelic mutations at this repeat. Conclusion Perhaps conflicting with common suspicions, the data are not compatible with selective pressures during tumorigenesis promoting the functional loss of BRCA2 and MRE11 in MSI tumors. Instead, these data fit closely with an absence of selective pressures acting on BRCA2 and MRE11 gene status during tumorigenesis.

  17. Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma

    Directory of Open Access Journals (Sweden)

    Gascoyne Randy D

    2009-11-01

    Full Text Available Abstract Background Translocations are hallmarks of non-Hodgkin lymphoma (NHL genomes. Because lymphoid cell development processes require the creation and repair of double stranded breaks, it is not surprising that disruption of this type of DNA repair can cause cancer. The members of the MRE11-RAD50-NBS1 (MRN complex and BLM have central roles in maintenance of DNA integrity. Severe mutations in any of these genes cause genetic disorders, some of which are characterized by increased risk of lymphoma. Methods We surveyed the genetic variation in these genes in constitutional DNA of NHL patients by means of gene re-sequencing, then conducted genetic association tests for susceptibility to NHL in a population-based collection of 797 NHL cases and 793 controls. Results 114 SNPs were discovered in our sequenced samples, 61% of which were novel and not previously reported in dbSNP. Although four variants, two in RAD50 and two in NBS1, showed association results suggestive of an effect on NHL, they were not significant after correction for multiple tests. Conclusion These results suggest an influence of RAD50 and NBS1 on susceptibility to diffuse large B-cell lymphoma and marginal zone lymphoma. Larger association and functional studies could confirm such a role.

  18. National Driver Register (NDR) -

    Data.gov (United States)

    Department of Transportation — Information regarding individuals who have had their driver licenses revoked, suspended or otherwise denied for cause, or who have been convicted of certain traffic...

  19. Criteria for driver impairment

    NARCIS (Netherlands)

    Brookhuis, K.A.; De Waard, D.; Fairclough, S.H

    2003-01-01

    Most traffic accidents can be attributed to driver impairment, e.g. inattention, fatigue, intoxication, etc. It is now technically feasible to monitor and diagnose driver behaviour with respect to impairment with the aid of a limited number of in-vehicle sensors. However, a valid framework for the

  20. DNA double strand break repair in mammalian cells: role of MRE11 and BLM proteins at the initiation of Non Homologous End Joining (NHEJ)

    International Nuclear Information System (INIS)

    Grabarz, Anastazja

    2011-01-01

    DNA double strand breaks (DSBs) are highly cytotoxic lesions, which can lead to genetic rearrangements. Two pathways are responsible for repairing these lesions: homologous recombination (HR) and non homologous end joining (NHEJ). In our laboratory, an intrachromosomal substrate has been established in order to measure the efficiency and the fidelity of NHEJ in living cells (Guirouilh-Barbat 2004). This approach led us to identify a KU-independent alternative pathway, which uses micro homologies in the proximity of the junction to accomplish repair - the alternative NHEJ (Guirouilh-Barbat 2004, Guirouilh-Barbat et Rass 2007). The goal of my thesis consisted in identifying and characterising major actors of this pathway. In the absence of KU, alternative NHEJ would be initiated by ssDNA resection of damaged ends. We showed that the nuclease activity of MRE11 is necessary for this mechanism. MRE11 overexpression leads to a two fold stimulation of NHEJ efficiency, while the extinction of MRE11 by siRNA results in a two fold decrease. Our results demonstrate that the proteins RAD50 and CtIP act in the same pathway as MRE11. Moreover, in cells deficient for XRCC4, MIRIN - an inhibitor of the MRN complex - leads to a decrease in repair efficiency, implicating MRE11 in alternative NHEJ. We also showed that MRE11 can act in an ATM-dependent and independent manner (Rass et Grabarz Nat Struct Mol Biol 2009). The initiation of break resection needs to be pursued by a more extensive degradation of DNA, which is accomplished in yeast by the proteins Exo1 and Sgs1/Dna2. In human cells, in vitro studies have recently proposed a similar model of a two-step break resection. We chose to elucidate the role of one of the human homologs of Sgs1 - the RecQ helicase BLM - in the resection process. Our experiments show, that he absence of BLM decreases the efficiency of end joining by NHEJ, accompanied by an increase in error-prone events, especially long-range deletions (≥200 nt). This

  1. The heat-inducible essential response regulator WalR positively regulates transcription of sigI, mreBH and lytE in Bacillus subtilis under heat stress.

    Science.gov (United States)

    Huang, Wan-Zhen; Wang, Jyun-Jhih; Chen, Hui-Ju; Chen, Jung-Tze; Shaw, Gwo-Chyuan

    2013-12-01

    The actin homolog MreBH governs cell morphogenesis of Bacillus subtilis through localization of the cell wall hydrolase LytE. The alternative sigma factor SigI of B. subtilis coordinately regulates transcription of mreBH and lytE. Transcription of sigI, mreBH and lytE is heat-inducible. The essential response regulator WalR (YycF) plays a key role in coordinating cell wall metabolism with cell proliferation. We now demonstrate that mreBH is a new member of the WalR regulon. We also found that WalR can positively and directly regulate sigI transcription under heat stress through a binding site located upstream of the σ(I) promoter of sigI. In addition, we found that a WalR binding site located upstream of the SigI binding site in the regulatory region of lytE is important for lytE expression under heat stress. Moreover, we found that walR is a new member of the heat shock stimulon of B. subtilis. WalR appears to coordinately and positively regulate transcription of sigI, mreBH and lytE under heat stress. Finally, our work shows for the first time that WalR can stimulate activities of σ(I) promoters under heat stress. Copyright © 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

  2. Drivers of Collaborative Advantage

    DEFF Research Database (Denmark)

    Weihe, Gudrid

    , the antecedents of collaborative advantage are theoretically examined, and the organizational competences contributing to collaborative success are identified. The conclusion is that operational processes and social dynamics are vital drivers of collaborative advantage. Another significant conclusion...

  3. Driver behavior in traffic.

    Science.gov (United States)

    2012-02-01

    Existing traffic analysis and management tools do not model the ability of drivers to recognize their environment and respond to it with behaviors that vary according to the encountered driving situation. The small body of literature on characterizin...

  4. General oilfield driver improvement

    International Nuclear Information System (INIS)

    Johnson, G.

    1997-01-01

    The general oilfield driver improvement (GODI) course was discussed. The course is offered to truckers in the oil and gas industry to help reduce accidents and injuries. Oilfield trucking is one of the most accident and injury prone sectors in the Alberta economy. This paper presented Heck's Trucking company's experience in sending its employees on the course. Drivers were taught (1) the National safety code requirements, (2) Commercial Vehicle Safety Alliance requirements, (3) occupational health and safety concerns, (4) vehicle dimension and GVW restrictions, (5) hours of service regulations, (6) log book and pre-trip inspection requirements, (7) workplace hazardous material information, and (8) transportation of dangerous goods. Overall, the course was judged to provide excellent training before sending drivers into the field. The employee, the customer, and the company, all stand to benefit from having rigorous and uniform standards for all drivers in the oil and gas industry

  5. Drug use among drivers

    Science.gov (United States)

    1975-02-01

    Randomly selected drivers were stopped at times and places of previous fatal crashes in Lincoln, Nebraska, and Dade County (Miami), Florida. Breath, urnine, blood, and lip swab samples were requested, for later analysis for drugs and medications. A c...

  6. Internet driver education study.

    Science.gov (United States)

    2010-05-01

    Incorporating technology through online courses, including drivers education (DE), is the wave of the future for : learning. While many states allow online DE as an accepted method of learning, Wisconsin currently only allows it on a : limited bas...

  7. Mass drivers. 3: Engineering

    Science.gov (United States)

    Arnold, W.; Bowen, S.; Cohen, S.; Fine, K.; Kaplan, D.; Kolm, M.; Kolm, H.; Newman, J.; Oneill, G. K.; Snow, W.

    1979-01-01

    The last of a series of three papers by the Mass-Driver Group of the 1977 Ames Summer Study is presented. It develops the engineering principles required to implement the basic mass-driver. Optimum component mass trade-offs are derived from a set of four input parameters, and the program used to design a lunar launcher. The mass optimization procedures is then incorporated into a more comprehensive mission optimization program called OPT-4, which evaluates an optimized mass-driver reaction engine and its performance in a range of specified missions. Finally, this paper discusses, to the extent that time permitted, certain peripheral problems: heating effects in buckets due to magnetic field ripple; an approximate derivation of guide force profiles; the mechanics of inserting and releasing payloads; the reaction mass orbits; and a proposed research and development plan for implementing mass drivers.

  8. Variations in Mre11/Rad50/Nbs1 status and DNA damage-induced S-phase arrest in the cell lines of the NCI60 panel

    Directory of Open Access Journals (Sweden)

    Eastman Alan

    2011-05-01

    Full Text Available Abstract Background The Mre11/Rad50/Nbs1 (MRN complex is a regulator of cell cycle checkpoints and DNA repair. Defects in MRN can lead to defective S-phase arrest when cells are damaged. Such defects may elicit sensitivity to selected drugs providing a chemical synthetic lethal interaction that could be used to target therapy to tumors with these defects. The goal of this study was to identify these defects in the NCI60 panel of cell lines and identify compounds that might elicit selective cytotoxicity. Methods We screened the NCI60 panel in search of cell lines that express low levels of MRN proteins, or that fail to arrest in S-phase in response to the topisomerase I inhibitor SN38. The NCI COMPARE program was used to discover compounds that preferentially target cells with these phenotypes. Results HCT116 cells were initially identified as defective in MRN and S phase arrest. Transfection with Mre11 also elevated Rad50 and Nbs1, and rescued the defective S-phase arrest. Cells of the NCI60 panel exhibited a large range of protein expression but a strong correlation existed between Mre11, Rad50 and Nbs1 consistent with complex formation determining protein stability. Mre11 mRNA correlated best with protein level suggesting it was the primary determinant of the overall level of the complex. Three other cell lines failed to arrest in response to SN38, two of which also had low MRN. However, other cell lines with low MRN still arrested suggesting low MRN does not predict an inability to arrest. Many compounds, including a family of benzothiazoles, correlated with the failure to arrest in S phase. The activity of benzothiazoles has been attributed to metabolic activation and DNA alkylation, but we note several cell lines in which sensitivity does not correlate with metabolism. We propose that the checkpoint defect imposes an additional mechanism of sensitivity on cells. Conclusions We have identified cells with possible defects in the MRN complex

  9. Coincident resection at both ends of random, γ-induced double-strand breaks requires MRX (MRN, Sae2 (Ctp1, and Mre11-nuclease.

    Directory of Open Access Journals (Sweden)

    James W Westmoreland

    2013-03-01

    Full Text Available Resection is an early step in homology-directed recombinational repair (HDRR of DNA double-strand breaks (DSBs. Resection enables strand invasion as well as reannealing following DNA synthesis across a DSB to assure efficient HDRR. While resection of only one end could result in genome instability, it has not been feasible to address events at both ends of a DSB, or to distinguish 1- versus 2-end resections at random, radiation-induced "dirty" DSBs or even enzyme-induced "clean" DSBs. Previously, we quantitatively addressed resection and the role of Mre11/Rad50/Xrs2 complex (MRX at random DSBs in circular chromosomes within budding yeast based on reduced pulsed-field gel electrophoretic mobility ("PFGE-shift". Here, we extend PFGE analysis to a second dimension and demonstrate unique patterns associated with 0-, 1-, and 2-end resections at DSBs, providing opportunities to examine coincidence of resection. In G2-arrested WT, Δrad51 and Δrad52 cells deficient in late stages of HDRR, resection occurs at both ends of γ-DSBs. However, for radiation-induced and I-SceI-induced DSBs, 1-end resections predominate in MRX (MRN null mutants with or without Ku70. Surprisingly, Sae2 (Ctp1/CtIP and Mre11 nuclease-deficient mutants have similar responses, although there is less impact on repair. Thus, we provide direct molecular characterization of coincident resection at random, radiation-induced DSBs and show that rapid and coincident initiation of resection at γ-DSBs requires MRX, Sae2 protein, and Mre11 nuclease. Structural features of MRX complex are consistent with coincident resection being due to an ability to interact with both DSB ends to directly coordinate resection. Interestingly, coincident resection at clean I-SceI-induced breaks is much less dependent on Mre11 nuclease or Sae2, contrary to a strong dependence on MRX complex, suggesting different roles for these functions at "dirty" and clean DSB ends. These approaches apply to resection at

  10. OLDER DRIVERS AND ADAS

    Directory of Open Access Journals (Sweden)

    Ragnhild J. DAVIDSE

    2006-01-01

    Next, based on the available literature, relevant ADAS are discussed in terms of their availability, their effects on safety and the willingness of older drivers to use and buy them. One of the conclusions is that only very few of the types of support that are thought to be most beneficial to the safety of older drivers are provided by the ADAS that are currently available.

  11. Drivers license display system

    Science.gov (United States)

    Prokoski, Francine J.

    1997-01-01

    Carjackings are only one of a growing class of law enforcement problems associated with increasingly violent crimes and accidents involving automobiles plays weapons, drugs and alcohol. Police traffic stops have become increasingly dangerous, with an officer having no information about a vehicle's potentially armed driver until approaching him. There are 15 million alcoholics in the US and 90 percent of them have drivers licenses. Many of them continue driving even after their licenses have ben revoked or suspended. There are thousands of unlicensed truck drivers in the country, and also thousands who routinely exceed safe operating periods without rest; often using drugs in an attempt to stay alert. MIKOS has developed the Drivers License Display Systems to reduce these and other related risks. Although every state requires the continuous display of vehicle registration information on every vehicle using public roads, no state yet requires the display of driver license information. The technology exists to provide that feature as an add-on to current vehicles for nominal cost. An initial voluntary market is expected to include: municipal, rental, and high value vehicles which are most likely to be mis-appropriated. It is anticipated that state regulations will eventually require such systems in the future, beginning with commercial vehicles, and then extending to high risk drivers and eventually all vehicles. The MIKOS system offers a dual-display approach which can be deployed now, and which will utilize all existing state licenses without requiring standardization.

  12. Graduated Driver Licensing

    Science.gov (United States)

    Bates, Lyndel J.; Allen, Siobhan; Armstrong, Kerry; Watson, Barry; King, Mark J.; Davey, Jeremy

    2014-01-01

    Graduated driver licensing (GDL) aims to gradually increase the exposure of new drivers to more complex driving situations and typically consists of learner, provisional and open licence phases. The first phase, the learner licence, is designed to allow novice drivers to obtain practical driving experience in lower risk situations. The learner licence can delay licensure, encourage novice drivers to learn under supervision, mandate the number of hours of practice required to progress to the next phase and encourage parental involvement. The second phase, the provisional licence, establishes various driving restrictions and thereby reduces exposure to situations of higher risk, such as driving at night, with passengers or after drinking alcohol. Parental involvement with a GDL system appears essential in helping novices obtain sufficient practice and in enforcing compliance with restrictions once the new driver obtains a provisional licence. Given the significant number of young drivers involved in crashes within Oman, GDL is one countermeasure that may be beneficial in reducing crash risk and involvement for this group. PMID:25364543

  13. Licensing procedures for older drivers.

    Science.gov (United States)

    2013-09-01

    This study examined the driver licensing procedures in all 50 States as they apply to the older (65+) driver. A literature review examined reports of possible declines in older driver capabilities and the ability of a driver licensing agency to scree...

  14. Pathogenic Chlamydia Lack a Classical Sacculus but Synthesize a Narrow, Mid-cell Peptidoglycan Ring, Regulated by MreB, for Cell Division.

    Directory of Open Access Journals (Sweden)

    George Liechti

    2016-05-01

    Full Text Available The peptidoglycan (PG cell wall is a peptide cross-linked glycan polymer essential for bacterial division and maintenance of cell shape and hydrostatic pressure. Bacteria in the Chlamydiales were long thought to lack PG until recent advances in PG labeling technologies revealed the presence of this critical cell wall component in Chlamydia trachomatis. In this study, we utilize bio-orthogonal D-amino acid dipeptide probes combined with super-resolution microscopy to demonstrate that four pathogenic Chlamydiae species each possess a ≤ 140 nm wide PG ring limited to the division plane during the replicative phase of their developmental cycles. Assembly of this PG ring is rapid, processive, and linked to the bacterial actin-like protein, MreB. Both MreB polymerization and PG biosynthesis occur only in the intracellular form of pathogenic Chlamydia and are required for cell enlargement, division, and transition between the microbe's developmental forms. Our kinetic, molecular, and biochemical analyses suggest that the development of this limited, transient, PG ring structure is the result of pathoadaptation by Chlamydia to an intracellular niche within its vertebrate host.

  15. Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation

    Science.gov (United States)

    Vallerga, María Belén; Mansilla, Sabrina F.; Federico, María Belén; Bertolin, Agustina P.; Gottifredi, Vanesa

    2015-01-01

    After UV irradiation, DNA polymerases specialized in translesion DNA synthesis (TLS) aid DNA replication. However, it is unclear whether other mechanisms also facilitate the elongation of UV-damaged DNA. We wondered if Rad51 recombinase (Rad51), a factor that escorts replication forks, aids replication across UV lesions. We found that depletion of Rad51 impairs S-phase progression and increases cell death after UV irradiation. Interestingly, Rad51 and the TLS polymerase polη modulate the elongation of nascent DNA in different ways, suggesting that DNA elongation after UV irradiation does not exclusively rely on TLS events. In particular, Rad51 protects the DNA synthesized immediately before UV irradiation from degradation and avoids excessive elongation of nascent DNA after UV irradiation. In Rad51-depleted samples, the degradation of DNA was limited to the first minutes after UV irradiation and required the exonuclease activity of the double strand break repair nuclease (Mre11). The persistent dysregulation of nascent DNA elongation after Rad51 knockdown required Mre11, but not its exonuclease activity, and PrimPol, a DNA polymerase with primase activity. By showing a crucial contribution of Rad51 to the synthesis of nascent DNA, our results reveal an unanticipated complexity in the regulation of DNA elongation across UV-damaged templates. PMID:26627254

  16. A Role for BLM in Double-Strand Break Repair Pathway Choice: Prevention of CtIP/Mre11-Mediated Alternative Nonhomologous End-Joining

    Directory of Open Access Journals (Sweden)

    Anastazja Grabarz

    2013-10-01

    Full Text Available The choice of the appropriate double-strand break (DSB repair pathway is essential for the maintenance of genomic stability. Here, we show that the Bloom syndrome gene product, BLM, counteracts CtIP/MRE11-dependent long-range deletions (>200 bp generated by alternative end-joining (A-EJ. BLM represses A-EJ in an epistatic manner with 53BP1 and RIF1 and is required for ionizing-radiation-induced 53BP1 focus assembly. Conversely, in the absence of 53BP1 or RIF1, BLM promotes formation of A-EJ long deletions, consistent with a role for BLM in DSB end resection. These data highlight a dual role for BLM that influences the DSB repair pathway choice: (1 protection against CtIP/MRE11 long-range deletions associated with A-EJ and (2 promotion of DNA resection. These antagonist roles can be regulated, according to cell-cycle stage, by interacting partners such as 53BP1 and TopIII, to avoid unscheduled resection that might jeopardize genome integrity.

  17. Effects of Initial Drivers and Land Use on WRF Modeling for Near-Surface Fields and Atmospheric Boundary Layer over the Northeastern Tibetan Plateau

    Directory of Open Access Journals (Sweden)

    Junhua Yang

    2016-01-01

    Full Text Available To improve the simulation performance of mesoscale models in the northeastern Tibetan Plateau, two reanalysis initial datasets (NCEP FNL and ERA-Interim and two MODIS (Moderate-Resolution Imaging Spectroradiometer land-use datasets (from 2001 and 2010 are used in WRF (Weather Research and Forecasting modeling. The model can reproduce the variations of 2 m temperature (T2 and 2 m relative humidity (RH2, but T2 is overestimated and RH2 is underestimated in the control experiment. After using the new initial drive and land use data, the simulation precision in T2 is improved by the correction of overestimated net energy flux at surface and the RH2 is improved due to the lower T2 and larger soil moisture. Due to systematic bias in WRF modeling for wind speed, we design another experiment that includes the Jimenez subgrid-scale orography scheme, which reduces the frequency of low wind speed and increases the frequency of high wind speed and that is more consistent with the observation. Meanwhile, the new drive and land-use data lead to lower boundary layer height and influence the potential temperature and wind speed in both the lower atmosphere and the upper layer, while the impact on water vapor mixing ratio is primarily concentrated in the lower atmosphere.

  18. Biogeochemical and microbial variation across 5500 km of Antarctic surface sediment implicates organic matter as a driver of benthic community structure

    Directory of Open Access Journals (Sweden)

    Deric R Learman

    2016-03-01

    Full Text Available Western Antarctica, one of the fastest warming locations on Earth, is a unique environment that is underexplored with regards to biodiversity. Although pelagic microbial communities in the Southern Ocean and coastal Antarctic waters have been well studied, there are fewer investigations of benthic communities and most have a focused geographic range. We sampled surface sediment from 24 sites across a 5,500 km region of Western Antarctica (covering the Ross Sea to the Weddell Sea to examine relationships between microbial communities and sediment geochemistry. Sequencing of the 16S and 18S rRNA genes showed microbial communities in sediments from the Antarctic Peninsula (AP and Western Antarctica (WA, including the Ross, Amundsen, and Bellingshausen Seas, could be distinguished by correlations with organic matter concentrations and stable isotope fractionation (total organic carbon; TOC, nitrogen, and δ13C. Overall, samples from the AP were higher in nutrient content (TOC, nitrogen, and NH4+ and communities in these samples had higher relative abundances of operational taxonomic units (OTUs classified as the diatom, Chaetoceros, a marine cercozoan and four OTUs classified as Cytophaga or Flavobacteria. As these OTUs were strongly correlated with TOC, the data suggests the diatoms could be a source of organic matter and the Bacteroidetes and cercozoan are grazers that consume the organic matter. Additionally, samples from WA have lower nutrients and were dominated by Thaumarchaeota, which could be related to their known ability to thrive as lithotrophs. This study documents the largest analysis of benthic microbial communities to date in the Southern Ocean, representing almost half the continental shoreline of Antarctica, and documents trophic interactions and coupling of pelagic and benthic communities. Our results indicate potential modifications in carbon sequestration processes related to change in community composition, identifying a

  19. Beginning teenage drivers

    Science.gov (United States)

    2010-01-01

    Teen drivers have the highest crash risk of any age group. Per mile traveled, they have the highest involvement rates in all types of crashes, from those involving only property damage to those that are fatal. The problem is worst among 16 year-olds,...

  20. Simulators in driver training.

    NARCIS (Netherlands)

    2009-01-01

    In 2010, about 150 driving simulators were being used for the basic driver training in the Netherlands. According to theories about how people learn, simulator training has both advantages and disadvantages. In order to be able to learn something from a simulator, its technical quality must be

  1. In Your Drivers' Hands.

    Science.gov (United States)

    Wright, Jim

    1993-01-01

    New federal rules mandate drug and alcohol testing for all school district employees who are required to have a commercial driver's license. Describes the major elements of a testing program and the types of testing required. Recommends building support for the testing program by involving employee labor leaders, board members, and a cross-section…

  2. distance bus drivers

    African Journals Online (AJOL)

    Kathryn van Boom

    N Rugbeer, 1 M Sport Science; N Neveling, 1 MSc Med;. T Sandla, 1 BTech Biokinetics. 1 Department of Sport, Rehabilitation and Dental Science, Tshwane. University of Technology, Pretoria, South Africa ... excessive stress along the kinetic chain and affect the driver's personal and social life.[2] A study in Ghana revealed ...

  3. Space Age Driver Education

    Science.gov (United States)

    Gray, Walter W.

    1970-01-01

    Describes experimental Driver and Traffic Safety Education Center--a project involving a five-phase instructional program, a variety of teaching innovations, and a specially-constructed facility which includes a classroom building, multiple car driving range, simulators, communications equipment, and the most recent electronic teaching devices.…

  4. Measuring and Ranking Value Drivers

    NARCIS (Netherlands)

    M.M. Akalu

    2002-01-01

    textabstractAnalysis of the strength of value drivers is crucial to understand their influence in the process of free cash flow generation. The paper addresses the issue of value driver measurement and ranking. The research reveals that, value drivers have similar pattern across industries.

  5. Driver feedback mobile APP

    Energy Technology Data Exchange (ETDEWEB)

    Soriguera Marti, F.; Miralles Miquel, E.

    2016-07-01

    This paper faces the human factor in driving and its consequences for road safety. It presents the concepts behind the development of a smartphone app capable of evaluating drivers’ performance. The app provides feedback to the driver in terms of a grade (between 0 and 10) depending on the aggressiveness and risks taken while driving. These are computed from the cumulative probability distribution function of the jerks (i.e. the time derivative of acceleration), which are measured using the smartphones’ accelerometer. Different driving contexts (e.g. urban, freeway, congestion, etc.) are identified applying cluster analysis to the measurements, and treated independently. Using regression analysis, the aggressiveness indicator is related to the drivers' safety records and to the probability of having an accident, through the standard DBQ - Driving Behavior Questionnaire. Results from a very limited pilot test show a strong correlation between the 99th percentile of the jerk measurements and the DBQ results. A linear model is fitted. This allows quantifying the safe driving behavior only from smartphone measurements. Finally, this indicator is translated into a normalized grade and feedback to the driver. This feedback will challenge the driver to train and to improve his performance. The phone will be blocked while driving and will incorporate mechanisms to prevent bad practices, like competition in aggressive driving. The app is intended to contribute to the improvement of road safety, one of the major public health problems, by tackling the human factor which is the trigger of the vast majority of traffic accidents. Making explicit and quantifying risky behaviors is the first step towards a safer driving. (Author)

  6. Automobile Driver Fingerprinting

    Directory of Open Access Journals (Sweden)

    Enev Miro

    2016-01-01

    Full Text Available Today’s automobiles leverage powerful sensors and embedded computers to optimize efficiency, safety, and driver engagement. However the complexity of possible inferences using in-car sensor data is not well understood. While we do not know of attempts by automotive manufacturers or makers of after-market components (like insurance dongles to violate privacy, a key question we ask is: could they (or their collection and later accidental leaks of data violate a driver’s privacy? In the present study, we experimentally investigate the potential to identify individuals using sensor data snippets of their natural driving behavior. More specifically we record the in-vehicle sensor data on the controllerarea- network (CAN of a typical modern vehicle (popular 2009 sedan as each of 15 participants (a performed a series of maneuvers in an isolated parking lot, and (b drove the vehicle in traffic along a defined ~ 50 mile loop through the Seattle metropolitan area. We then split the data into training and testing sets, train an ensemble of classifiers, and evaluate identification accuracy of test data queries by looking at the highest voted candidate when considering all possible one-vs-one comparisons. Our results indicate that, at least among small sets, drivers are indeed distinguishable using only incar sensors. In particular, we find that it is possible to differentiate our 15 drivers with 100% accuracy when training with all of the available sensors using 90% of driving data from each person. Furthermore, it is possible to reach high identification rates using less than 8 minutes of training data. When more training data is available it is possible to reach very high identification using only a single sensor (e.g., the brake pedal. As an extension, we also demonstrate the feasibility of performing driver identification across multiple days of data collection

  7. Education and driver-training

    Directory of Open Access Journals (Sweden)

    Andrej Justinek

    1999-12-01

    Full Text Available The characteristics of the driver are manifested in his/her behaviour. For safe driving one must have a driver's knowledge. The contents of educational material are determined by law, and are both theoretical and practical, yet frequently they do not suffice to meet the requirements of safe driving. In this paper, the author suggests that, in the training of drivers, more educational elements should be included, such a would have  an effective influence on the driver's moti ves and attitudes. The driver's motives - which may result in incorrect driving­ are diverse: most often, the default is overspeeding, even though the drivers always over-estimate the potential time gain. In fact, over-fast driving is a way of satisfying other, different needs; and, above all, it is a form of compensation for unsettled life problems, and at the same time an indication of the driver's personal inability to cope with stress.

  8. Are professional drivers less sleepy than non-professional drivers?

    Science.gov (United States)

    Anund, Anna; Ahlström, Christer; Fors, Carina; Åkerstedt, Torbjörn

    2018-01-01

    Objective It is generally believed that professional drivers can manage quite severe fatigue before routine driving performance is affected. In addition, there are results indicating that professional drivers can adapt to prolonged night shifts and may be able to learn to drive without decreased performance under high levels of sleepiness. However, very little research has been conducted to compare professionals and non-professionals when controlling for time driven and time of day. Method The aim of this study was to use a driving simulator to investigate whether professional drivers are more resistant to sleep deprivation than non-professional drivers. Differences in the development of sleepiness (self-reported, physiological and behavioral) during driving was investigated in 11 young professional and 15 non-professional drivers. Results Professional drivers self-reported significantly lower sleepiness while driving a simulator than non-professional drivers. In contradiction, they showed longer blink durations and more line crossings, both of which are indicators of sleepiness. They also drove faster. The reason for the discrepancy in the relation between the different sleepiness indicators for the two groups could be due to more experience to sleepiness among the professional drivers or possibly to the faster speed, which might unconsciously have been used by the professionals to try to counteract sleepiness. Conclusion Professional drivers self-reported significantly lower sleepiness while driving a simulator than non-professional drivers. However, they showed longer blink durations and more line crossings, both of which are indicators of sleepiness, and they drove faster.

  9. Heavy ion driver technology

    International Nuclear Information System (INIS)

    Keefe, D.

    1988-09-01

    Major differences between fusion drivers and traditional accelerators include the following. The final beam current needed (/approximately/20 kA in a short pulse) is very much larger for a driver; such beams are dominated by repulsive space-charge effects since, even at 10 GeV, the ions are non-relativistic (v/c = 0.3). Also, the optical quality of the beams (called emittance by accelerator people) must be extremely good to ensure a suitably small focal spot at the pellet. Two schemes, one with a rf linac and storage rings, the other with a single-pass current-amplifying induction linac, are under study, the latter exclusively in the US. The induction linac approach lends itself to an examination in a sequence of scaled-down laboratory experiments since the most difficulties are expected to occur at the low energy end. Experiments and simulation have centered on a study of the transverse and longitudinal control of space-charge-dominated beams which are best described in terms of a non-neutral plasma rather than the traditional single-particle dynamics picture. An understanding of the high-current instability limits is required for arriving at a safe driver design. The final on-target beam current is so high that it must be carried in 16 separate focusing channels leading into the combustion chamber. While the energy deposition of the ions is expected to be entirely classical, there is a wealth of plasma physics phenomena to be explored (by theory and simulation) in the final propagation of these beams through the low-density gas in the chamber and in the environment of the hot target; it is important that none of these could result in a significant portion of the beam missing the focal spot. 13 refs., 9 figs., 1 tab

  10. Drivers for Welfare Innovation

    DEFF Research Database (Denmark)

    Wegener, Charlotte

    2015-01-01

    on the empirical material, the paper proposes a ‘driver’ model for context sensitive research of innovation in welfare workplaces. The model involves three elements which can be regarded as drivers for innovation: i) craft (i.e. professional skills and knowledge), ii) levers (i.e. experiments and adjustment......Innovation has become a key goal towards which teaching and workplace learning needs to be directed. Now perceived as germane and even necessary in almost all kinds of welfare work, the innovation potential in everyday practices and ways of allowing for employer creativity have become a highly...

  11. Driver Distraction in Public Transport

    OpenAIRE

    YOUNG, K; SALMON, P; REGAN MICHAEL, M

    2007-01-01

    There is converging evidence that driver distraction is a contributing factor in car crashes, in Australia and overseas. Surprisingly, no known previous research has attempted to identify and assess the potentially distracting activities undertaken by the drivers of public passenger vehicles. This paper describes research undertaken on this issue. The research was partitioned into three phases: an analysis of the functions and tasks currently undertaken by public passenger vehicle drivers; th...

  12. Random drivers for all sizes

    International Nuclear Information System (INIS)

    Olsen, R.N.; Untermyer, S. II; Miller, H.; Lung, J.

    1976-01-01

    This paper discusses two new Random Drivers built by NNC. The smaller machine, Mini Random Driver, is designed to give high sensitivity for small samples (10 mg Pu). The larger machine, Jumbo Random Driver, is designed to assay material in large containers including 200 1 (55 gal) waste barrels and large filters. These systems can assay uranium or plutonium in either active or passive modes. A description of each instrument with calibration results is presented

  13. A new method for quantifying and modeling large scale surface water inundation dynamics and key drivers using multiple time series of Earth observation and river flow data. A case study for Australia's Murray-Darling Basin

    Science.gov (United States)

    Heimhuber, Valentin; Tulbure, Mirela G.; Broich, Mark

    2017-04-01

    Periodically inundated surface water (SW) areas such as floodplains are hotspots of biodiversity and provide a broad range of ecosystem services but have suffered alarming declines in recent history. Large scale flooding events govern the dynamics of these areas and are a critical component of the terrestrial water cycle, but their propagation through river systems and the corresponding long term SW dynamics remain poorly quantified on continental or global scales. In this research, we used an unprecedented Landsat-based time series of SW maps (1986-2011), to develop statistical inundation models and quantify the role of driver variables across the Murray-Darling Basin (MDB) (1 million square-km), which is Australia's bread basket and subject to competing demands over limited water resources. We fitted generalized additive models (GAM) between SW extent as the dependent variable and river flow data from 68 gauges, spatial time series of rainfall (P; interpolated gauge data), evapotranspiration (ET; AWRA-L land surface model) and soil moisture (SM; active passive microwave satellite remote sensing) as predictor variables. We used a fully directed and connected river network (Australian Geofabric) in combination with ancillary data, to develop a spatial modeling framework consisting of 18,521 individual modeling units. We then fitted individual models for all modeling units, which were made up of 10x10 km grid cells split into floodplain, floodplain-lake and non-floodplain areas, depending on the type of water body and its hydrologic connectivity to a gauged river. We applied the framework to quantify flood propagation times for all major river and floodplain systems across the MDB, which were in good accordance with observed travel times. After incorporating these flow lag times into the models, average goodness of fit was high across floodplains and floodplain-lake modeling units (r-squared > 0.65), which were primarily driven by river flow, and lower for non

  14. Drivers of Collaborative Advantage

    DEFF Research Database (Denmark)

    Weihe, Gudrid

    Drawing upon extant alliance literature, this article substantiates the argument that we need to look beyond mere structural and formative aspects of cooperation in order to fully understand the performance antecedents of public-private partnerships. Currently, scholarly work on operational......, the antecedents of collaborative advantage are theoretically examined, and the organizational competences contributing to collaborative success are identified. The conclusion is that operational processes and social dynamics are vital drivers of collaborative advantage. Another significant conclusion...... is that public management research can benefit from drawing upon existing alliance research. Alliance scholars have during the past couple of decades accumulated an impressive amount of knowledge on different aspects of inter-firm cooperation, and therefore the learning potential for public management scholars...

  15. Analiza tačnosti visina bosanskohercegovačke trigonometrijske mreže pomoću GPS/EGM podataka : Accuracy analyses of B&H trigonometric network heights by GPS/EGM data

    Directory of Open Access Journals (Sweden)

    Medžida Mulić

    2012-06-01

    Full Text Available Dostupnost savremenih globalnih geoidnih modela kao i 3D koordinata u globalnom koordinatnom referentnom sistemu omogućava anlazu tačnosti ortometrijskih visina trionometrijske mreže. Rad pokazuje preliminarne rezultate analize tačnosti visina trigonometrijske mreže u Bosni i Hercegovini, a na osnovu usporedbe visina izračunatih korištenjem GPS visina i EGM geoidnih modela. Preliminarni rezultati ukazuju na postojanje grubih pogrešaka u visinama trigonometrijskih tačaka BiH trigonometrijske mreže. : Analysis of the accuracy of the orthometric heights of the old trigonometric points are posible since the global accurate models of geoid as well as 3D coordinates in the global coordinate system became available. Preliminary results of the heights accuracy analyze in the old trigonometric network in the in Bosnia and Herzegovina are shown in this paper. The analyze has done by comparing the orthometric heights calculated using by GPS height and the modern global geoid models EGM, with the old official heights of trigonometric points. The results indicate the existence of blunders among the heights in the old trigonometric network of Bosnia and Herzegovina.

  16. Zaštita računarskih mreža Ministarstva odbrane i Vojske Srbije primenom virtuelnog honeyneta / Security of computer network of the Ministry of Defence and the Serbian Armed Forces using virtual honeynets

    Directory of Open Access Journals (Sweden)

    Zoran Bobar

    2009-07-01

    Full Text Available U ovom radu obrađena je zaštita računarskih mreža u Ministarstvu odbrane i Vojsci Srbije primenom virtuelnog honeyneta. Zaštita je obrađena sa aspekta arhitekture računarskih mreža koje imaju pristup internetu. Predloženi koncept primene virtuelnog honeyneta uzima u obzir dostignuća nauke u ovoj oblasti u svetu, ostale primenjene metode i tehnike zaštite, mogućnosti i potrebe korisnika i elemente delova računarskog sistema Ministarstva odbrane i Vojske koji bi mogli biti meta napada sa udaljenih mesta globalne (internet mreže. / This paper covers the proposed solution for security of computer network in the Ministry of Defence and the Serbian Armed Forces using virtual honeynets. The security is covered from the aspect of the architecture of computer networks with Internet access. The proposed usage of virtual honeynets for protection takes into account the accomplishments of science in this field as well as security methods and techniques, users' needs and opportunities along with the computer network components of the MoD and the SAF that can be targets for attack.

  17. A holistic perspective on corporate sustainability drivers

    NARCIS (Netherlands)

    Lozano, Rodrigo|info:eu-repo/dai/nl/36412380X

    2015-01-01

    Since company boards are increasingly discussing 'sustainability', it becomes necessary to examine the nature of sustainability drivers. Most approaches to corporate sustainability drivers have focused either on internal or external drivers. This paper is aimed at providing a more holistic

  18. A holistic perspective on corporate sustainability drivers

    NARCIS (Netherlands)

    Lozano, R.

    2013-01-01

    Since company boards are increasingly discussing 'sustainability', it becomes necessary to examine the nature of sustainability drivers. Most approaches to corporate sustainability drivers have focused either on internal or external drivers. This paper is aimed at providing a more holistic

  19. Heavy-ion driver design and scaling

    International Nuclear Information System (INIS)

    Bieri, R.; Monsler, M.; Meier, W.; Stewart, L.

    1992-01-01

    Parametric models for scaling heavy-ion driver designs are described. Scaling of target performance and driver cost is done for driver parameters including driver energy, number of beams, type of superconductor used in focusing magnets, maximum magnetic field allowed at the superconducting windings, linear quadrupole array packing fraction mass, and ion charge state. The cumulative accelerator voltage and beam currents are determined from the Maschke limits on beam current for each choice of driver energy and post-acceleration pulse duration. The heavy-ion driver is optimized over the large available driver parameter space. Parametric studies and the choice of a base driver model are described in a companion paper

  20. Are professional drivers less sleepy than non-professional drivers?

    OpenAIRE

    Anund, Anna; Ahlström, Christer; Fors, Carina; Åkerstedt, Torbjorn

    2018-01-01

    Objective It is generally believed that professional drivers can manage quite severe fatigue before routine driving performance is affected. In addition, there are results indicating that professional drivers can adapt to prolonged night shifts and may be able to learn to drive without decreased performance under high levels of sleepiness. However, very little research has been conducted to compare professionals and non-professionals when controlling for time driven and time of day. Method Th...

  1. Innovation Driver Nanoelectronics

    Science.gov (United States)

    Lakner, Hubert

    2013-03-01

    When addressing the global societal challenges most solutions will require Nano electronics and Smart Systems - therefore innovation today is mainly based on nanoelectronics which has become one of the most important key enabling technologies and innovation drivers. Nanoelectronics has been extended by other microtechnologies. This results in additional functionalities. The combination of analog and digital electronics, the integration of sensors and actuators, of power devices and rf components on wafer level makes it possible to shrink shoebox sized systems to the size of a matchbox. But there is no innovation without research. Europe (Germany) is top in invention but poor in commercialization - many good ideas fail when going from research to production within the so-called Valley of Death. To overcome this, a clear strategy is necessary. Silicon Saxony, the big Saxonian cluster on micro- and nanoelectronics is presented as a best practice example: clear focus, addressing whole value chains and establishing joint technology platforms has led to a remarkable commercial success in the Dresden area.

  2. Older-driver foot movements.

    Science.gov (United States)

    2017-07-01

    This study explored how drivers 60 and older control the accelerator and brake while driving and parking. It built upon : the findings of a study documenting the prevalence and characteristics associated with pedal misapplication crashes : (Lococo, S...

  3. Roundabout design and elderly drivers.

    Science.gov (United States)

    2011-10-01

    Many drivers are apprehensive to accept a roundabout as a viable form of intersection, but their : safety and mobility benefits are increasing their popularity among designers. This thesis is an indepth study of a specific approach at a roundabout in...

  4. Alcohol and older drivers' crashes.

    Science.gov (United States)

    2014-09-01

    Researchers have examined the effects of alcohol consumption : on older adults functioning, and some have : addressed alcohols effects on older drivers crash risk. : Generally, the findings have shown that alcohol is less : likely to be a fa...

  5. Teen driver cell phone blocker.

    Science.gov (United States)

    2012-02-01

    This study was a randomized control intervention to measure the effectiveness of a cellular phone control device : that communicates with the vehicles of teen drivers to deny them access to their phone while driving for the : purpose of reducing dist...

  6. Adaptive object placement for augmented reality use in driver assistance systems

    OpenAIRE

    Bordes, Lucie; Breckon, Toby P.; Katramados, Ioannis; Kheyrollahi, Alireza

    2011-01-01

    We present an approach for adaptive object placement for Augmented Reality (AR) use in driver assistance systems. Combined vanishing point and road surface detection enable the real-time adaptive emplacement of AR objects within a drivers' natural field of view for on-road information display. This work combines both automotive vision and multimedia production aspects of real-time visual engineering.

  7. 49 CFR 380.109 - Driver testing.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Driver testing. 380.109 Section 380.109....109 Driver testing. (a) Testing methods. The driver-student must pass knowledge and skills tests in... LCV driver-instructor. (d) Guidance for testing methods and proficiency determinations. Motor carriers...

  8. Locomotor diseases among male long-haul truck drivers and other professional drivers

    DEFF Research Database (Denmark)

    Jensen, Anker; Kaerlev, Linda; Tüchsen, Finn

    2007-01-01

    -249) and for other truck drivers (SHR: 130, 95% CI: 108-156) compared to bus drivers (SHR: 110, 95% CI: 79-149). All drivers had high SHR for lesions of the ulnar nerve (SHR: 159, 95% CI: 119-207), especially bus drivers (SHR: 197, 95% CI: 116-311). Long-haul truck drivers had high SHRs for synovitis and bursitis...

  9. Synoptic and meteorological drivers of extreme ozone concentrations over Europe

    Science.gov (United States)

    Otero, Noelia Felipe; Sillmann, Jana; Schnell, Jordan L.; Rust, Henning W.; Butler, Tim

    2016-04-01

    The present work assesses the relationship between local and synoptic meteorological conditions and surface ozone concentration over Europe in spring and summer months, during the period 1998-2012 using a new interpolated data set of observed surface ozone concentrations over the European domain. Along with local meteorological conditions, the influence of large-scale atmospheric circulation on surface ozone is addressed through a set of airflow indices computed with a novel implementation of a grid-by-grid weather type classification across Europe. Drivers of surface ozone over the full distribution of maximum daily 8-hour average values are investigated, along with drivers of the extreme high percentiles and exceedances or air quality guideline thresholds. Three different regression techniques are applied: multiple linear regression to assess the drivers of maximum daily ozone, logistic regression to assess the probability of threshold exceedances and quantile regression to estimate the meteorological influence on extreme values, as represented by the 95th percentile. The relative importance of the input parameters (predictors) is assessed by a backward stepwise regression procedure that allows the identification of the most important predictors in each model. Spatial patterns of model performance exhibit distinct variations between regions. The inclusion of the ozone persistence is particularly relevant over Southern Europe. In general, the best model performance is found over Central Europe, where the maximum temperature plays an important role as a driver of maximum daily ozone as well as its extreme values, especially during warmer months.

  10. Examination of supplemental driver training and online basic driver education courses : traffic tech.

    Science.gov (United States)

    2012-08-01

    The first six months of unsupervised driving are the most : hazardous in a novice drivers driving experience. Most : States adopted graduated driver licensing (GDL) systems : to give novice drivers experience in a protective environment, : gradual...

  11. Key drivers of airline loyalty

    Science.gov (United States)

    Dolnicar, Sara; Grabler, Klaus; Grün, Bettina; Kulnig, Anna

    2011-01-01

    This study investigates drivers of airline loyalty. It contributes to the body of knowledge in the area by investigating loyalty for a number of a priori market segments identified by airline management and by using a method which accounts for the multi-step nature of the airline choice process. The study is based on responses from 687 passengers. Results indicate that, at aggregate level, frequent flyer membership, price, the status of being a national carrier and the reputation of the airline as perceived by friends are the variables which best discriminate between travellers loyal to the airline and those who are not. Differences in drivers of airline loyalty for a number of segments were identified. For example, loyalty programs play a key role for business travellers whereas airline loyalty of leisure travellers is difficult to trace back to single factors. For none of the calculated models satisfaction emerged as a key driver of airline loyalty. PMID:27064618

  12. UWB dual burst transmit driver

    Science.gov (United States)

    Dallum, Gregory E [Livermore, CA; Pratt, Garth C [Discovery Bay, CA; Haugen, Peter C [Livermore, CA; Zumstein, James M [Livermore, CA; Vigars, Mark L [Livermore, CA; Romero, Carlos E [Livermore, CA

    2012-04-17

    A dual burst transmitter for ultra-wideband (UWB) communication systems generates a pair of precisely spaced RF bursts from a single trigger event. An input trigger pulse produces two oscillator trigger pulses, an initial pulse and a delayed pulse, in a dual trigger generator. The two oscillator trigger pulses drive a gated RF burst (power output) oscillator. A bias driver circuit gates the RF output oscillator on and off and sets the RF burst packet width. The bias driver also level shifts the drive signal to the level that is required for the RF output device.

  13. Schoolbus driver performance can be improved with driver training ...

    African Journals Online (AJOL)

    In South Africa (SA), the school transport industry provides millions of children with a means of travelling to and from school. The industry has, however, been reported to be plagued by widespread safety concerns. The consequent road traffic incidents have often been attributed to driver factors, including driving in excess of ...

  14. Driver style and driver skills – clustering drivers differing in their potential danger in traffic

    DEFF Research Database (Denmark)

    Martinussen, Laila Marianne; Møller, Mette; Prato, Carlo Giacomo

    , annual mileage and accident involvement. 3908 drivers aged 18–84 participated in the survey. The results suggested that the drivers have good insight into their own driving ability, as the driving skill level mirrored the frequency of aberrant driving behaviors. K-means cluster analysis revealed four...... distinct clusters that differed in the frequency of aberrant driving behavior and driving skills, as well as individual characteristics and driving related factors such as annual mileage, accident frequency and number of tickets and fines. Thus, two sub-groups were identified as more unsafe than the two...

  15. Drivers and Limits for Transport

    DEFF Research Database (Denmark)

    Kristensen, Niels Buus; Nielsen, Thomas A. Sick; Gudmundsson, Henrik

    This report summarizes key outcomes of the study ’Drivers and Limits’ that was supported for the period 2009-2013 by a research grant from the Danish Strategic Research Council. The project investigated - for the empirical context of Denmark - key driving forces behind transport growth, as well...

  16. Driver Psychology during Automated Platooning

    NARCIS (Netherlands)

    Heikoop, D.D.

    2017-01-01

    With the rapid increase in vehicle automation technology, the call for understanding how humans behave while driving in an automated vehicle becomes more urgent. Vehicles that have automated systems such as Lane Keeping Assist (LKA) or Adaptive Cruise Control (ACC) not only support drivers in their

  17. Synthesis, characterization and biological evaluation of novel neutral fac-M(CO){sub 3}(SNO) complexes (M=Re, {sup 99m}Tc) bearing the o-methoxyphenylpiperazine moiety

    Energy Technology Data Exchange (ETDEWEB)

    Chiotellis, A. [Institute of Radioisotopes, Radiodiagnostic Products, National Centre for Scientific Research ' Demokritos' , 15310 Ag. Paraskevi, Athens (Greece); Tsoukalas, C., E-mail: ctsoukal@rrp.demokritos.gr [Institute of Radioisotopes, Radiodiagnostic Products, National Centre for Scientific Research ' Demokritos' , 15310 Ag. Paraskevi, Athens (Greece); Pelecanou, M. [Institute of Biology, National Centre for Scientific Research ' Demokritos' , 15310 Ag. Paraskevi, Athens (Greece); Pirmettis, I.; Papadopoulos, M. [Institute of Radioisotopes, Radiodiagnostic Products, National Centre for Scientific Research ' Demokritos' , 15310 Ag. Paraskevi, Athens (Greece)

    2012-06-15

    The synthesis, characterization and biological evaluation of two new neutral tricarbonyl fac-M(CO){sub 3}(SNO) (M=Re, {sup 99m}Tc) bearing o-methoxyphenylpiperazine as pharmacophore and S-functionalized cysteine or penicillamine as chelators are reported. Competition binding tests showed good affinity for the 5-HT{sub 1A} receptor (8 and 54 nM for 4a and 4b, respectively). Biodistribution studies in healthy animals showed high initial blood and liver uptake, fast blood and tissue depuration and negligible brain uptake. - Graphical abstract: Two new neutral tricarbonyl fac-M(CO){sub 3}(SNO) (M=Re, {sup 99m}Tc) bearing o-methoxyphenylpiperazine as pharmacophore and S-functionalized cysteine or penicillamine as chelator were synthesized, characterized and evaluated as possible 5-HT{sub 1A} receptor imaging agents. Highlights: Black-Right-Pointing-Pointer S-functionalized cysteine or penicillamine for the 5-HT{sub 1A} receptors are reported. Black-Right-Pointing-Pointer Novel rhenium and technetium-99m tricarbonyl complexes were synthesized and characterized. Black-Right-Pointing-Pointer Competition binding tests showed good affinity for the 5-HT{sub 1A} receptors. Black-Right-Pointing-Pointer The {sup 99m}Tc complexes showed adequate features but negligible brain uptake in mice.

  18. Older drivers' foot movements : traffic tech.

    Science.gov (United States)

    2017-07-01

    This study explored how older drivers use their accelerator and : brake pedals, to identify characteristics that could pose an increased : risk of a pedal application error. The study also explored whether : driver-vehicle fit was related to these ch...

  19. Free electron laser as a fusion driver

    International Nuclear Information System (INIS)

    Prosnitz, D.; Schlitt, L.

    1981-01-01

    The Free Electron Laser (FEL) is shown to be a potentially attractive solution to the problem of finding a suitable short wavelength fusion driver. The design of a 3 MJ, 250 nm FEL fusion driver is discussed

  20. Feasibility study on evaluating driver education curriculum.

    Science.gov (United States)

    2009-04-01

    One way to attempt to reduce the problem of teen driving crashes is professional driver education. However, despite the : seemingly universal appeal of driver education, scientific evaluations have indicated that such programs generally do not : prod...

  1. Improving driver safety with behavioral countermeasures.

    Science.gov (United States)

    2011-09-30

    "The purpose of this project was to provide MDOT with insight regarding the effectiveness of potential implementations of behavioral countermeasures for increasing driver safety in Michigan. The Center for Driver Evaluation, Education, and Research a...

  2. Managing drivers of innovation in construction networks

    NARCIS (Netherlands)

    Bossink, B.A.G.

    2004-01-01

    Various drivers of construction innovation are distinguished and classified in four distinctive categories: environmental pressure, technological capability, knowledge exchange, and boundary spanning. Innovation drivers in these categories are active at the transfirm, intrafirm, and interfirm level

  3. 49 CFR 396.13 - Driver inspection.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS INSPECTION, REPAIR, AND MAINTENANCE § 396.13 Driver inspection. Before driving a motor vehicle, the driver shall: (a) Be satisfied that the motor vehicle is in safe operating condition; (b) Review the last driver vehicle inspection...

  4. Factors Contributing to Crashes among Young Drivers

    Directory of Open Access Journals (Sweden)

    Lyndel J. Bates

    2014-08-01

    Full Text Available Young drivers are the group of drivers most likely to crash. There are a number of factors that contribute to the high crash risk experienced by these drivers. While some of these factors are intrinsic to the young driver, such as their age, gender or driving skill, others relate to social factors and when and how often they drive. This article reviews the factors that affect the risk of young drivers crashing to enable a fuller understanding of why this risk is so high in order to assist in developing effective countermeasures.

  5. Visualization drivers for Geant4

    International Nuclear Information System (INIS)

    Beretvas, Andy

    2005-01-01

    This document is on Geant 4 visualization tools (drivers), evaluating pros and cons of each option, including recommendations on which tools to support at Fermilab for different applications. Four visualization drivers are evaluated. They re OpenGL, HepRep, DAWN and VRML. They all have good features, OpenGL provides graphic output with out an intermediate file. HepRep provides menus to assist the user. DAWN provides high quality plots and even for large files produces output quickly. VRML uses the smallest disk space for intermediate files. Large experiments at Fermilab will want to write their own display. They should proceed to make this display graphics independent. Medium experiment will probably want to use HepRep because of it's menu support. Smaller scale experiments will want to use OpenGL in the spirit of having immediate response, good quality output and keeping things simple

  6. Visualization drivers for Geant4

    Energy Technology Data Exchange (ETDEWEB)

    Beretvas, Andy; /Fermilab

    2005-10-01

    This document is on Geant4 visualization tools (drivers), evaluating pros and cons of each option, including recommendations on which tools to support at Fermilab for different applications. Four visualization drivers are evaluated. They are OpenGL, HepRep, DAWN and VRML. They all have good features, OpenGL provides graphic output without an intermediate file. HepRep provides menus to assist the user. DAWN provides high quality plots and even for large files produces output quickly. VRML uses the smallest disk space for intermediate files. Large experiments at Fermilab will want to write their own display. They should proceed to make this display graphics independent. Medium experiment will probably want to use HepRep because of it's menu support. Smaller scale experiments will want to use OpenGL in the spirit of having immediate response, good quality output and keeping things simple.

  7. Advancing the integration of spatial data to map human and natural drivers on coral reefs.

    Science.gov (United States)

    Wedding, Lisa M; Lecky, Joey; Gove, Jamison M; Walecka, Hilary R; Donovan, Mary K; Williams, Gareth J; Jouffray, Jean-Baptiste; Crowder, Larry B; Erickson, Ashley; Falinski, Kim; Friedlander, Alan M; Kappel, Carrie V; Kittinger, John N; McCoy, Kaylyn; Norström, Albert; Nyström, Magnus; Oleson, Kirsten L L; Stamoulis, Kostantinos A; White, Crow; Selkoe, Kimberly A

    2018-01-01

    A major challenge for coral reef conservation and management is understanding how a wide range of interacting human and natural drivers cumulatively impact and shape these ecosystems. Despite the importance of understanding these interactions, a methodological framework to synthesize spatially explicit data of such drivers is lacking. To fill this gap, we established a transferable data synthesis methodology to integrate spatial data on environmental and anthropogenic drivers of coral reefs, and applied this methodology to a case study location-the Main Hawaiian Islands (MHI). Environmental drivers were derived from time series (2002-2013) of climatological ranges and anomalies of remotely sensed sea surface temperature, chlorophyll-a, irradiance, and wave power. Anthropogenic drivers were characterized using empirically derived and modeled datasets of spatial fisheries catch, sedimentation, nutrient input, new development, habitat modification, and invasive species. Within our case study system, resulting driver maps showed high spatial heterogeneity across the MHI, with anthropogenic drivers generally greatest and most widespread on O'ahu, where 70% of the state's population resides, while sedimentation and nutrients were dominant in less populated islands. Together, the spatial integration of environmental and anthropogenic driver data described here provides a first-ever synthetic approach to visualize how the drivers of coral reef state vary in space and demonstrates a methodological framework for implementation of this approach in other regions of the world. By quantifying and synthesizing spatial drivers of change on coral reefs, we provide an avenue for further research to understand how drivers determine reef diversity and resilience, which can ultimately inform policies to protect coral reefs.

  8. Advancing the integration of spatial data to map human and natural drivers on coral reefs

    Science.gov (United States)

    Gove, Jamison M.; Walecka, Hilary R.; Donovan, Mary K.; Williams, Gareth J.; Jouffray, Jean-Baptiste; Crowder, Larry B.; Erickson, Ashley; Falinski, Kim; Friedlander, Alan M.; Kappel, Carrie V.; Kittinger, John N.; McCoy, Kaylyn; Norström, Albert; Nyström, Magnus; Oleson, Kirsten L. L.; Stamoulis, Kostantinos A.; White, Crow; Selkoe, Kimberly A.

    2018-01-01

    A major challenge for coral reef conservation and management is understanding how a wide range of interacting human and natural drivers cumulatively impact and shape these ecosystems. Despite the importance of understanding these interactions, a methodological framework to synthesize spatially explicit data of such drivers is lacking. To fill this gap, we established a transferable data synthesis methodology to integrate spatial data on environmental and anthropogenic drivers of coral reefs, and applied this methodology to a case study location–the Main Hawaiian Islands (MHI). Environmental drivers were derived from time series (2002–2013) of climatological ranges and anomalies of remotely sensed sea surface temperature, chlorophyll-a, irradiance, and wave power. Anthropogenic drivers were characterized using empirically derived and modeled datasets of spatial fisheries catch, sedimentation, nutrient input, new development, habitat modification, and invasive species. Within our case study system, resulting driver maps showed high spatial heterogeneity across the MHI, with anthropogenic drivers generally greatest and most widespread on O‘ahu, where 70% of the state’s population resides, while sedimentation and nutrients were dominant in less populated islands. Together, the spatial integration of environmental and anthropogenic driver data described here provides a first-ever synthetic approach to visualize how the drivers of coral reef state vary in space and demonstrates a methodological framework for implementation of this approach in other regions of the world. By quantifying and synthesizing spatial drivers of change on coral reefs, we provide an avenue for further research to understand how drivers determine reef diversity and resilience, which can ultimately inform policies to protect coral reefs. PMID:29494613

  9. Mass Driver Two - Cryogenic module

    Science.gov (United States)

    Fine, K.; Williams, F.; Mongeau, P.; Kolm, H.

    1979-01-01

    The cryogenic module of Mass Driver Two comprises a 3.25 inch (82.55 mm) OD bucket with two 44 kilo-ampere-turn coils made with .028 inch (.71 mm) diam niobium-titanium multi-filamentary cable in a copper matrix, impregnated with lead alloy for thermal inertia, as well as the service station to refrigerate, energize and eject the bucket. The station is housed in a six inch flanged pyrex cross which connects to the four inch pyrex tube of the mass driver itself. The bucket is refrigerated by being forced against a copper braid cradle attached to the bottom of a liquid helium reservoir which protrudes into the cross from above. The bucket is energized inductively by turning off two superconducting coils which are also attached to the helium reservoir, and which have maintained the correct flux linkage through the bucket coils during their cool-down through the critical temperature. Once charging is completed, the clamping pressure is released and the bucket is injected into the mass driver by means of two normal-conductor pulse coils surrounding the horizontal branches of the cross.

  10. Driving fatigue in professional drivers: a survey of truck and taxi drivers.

    Science.gov (United States)

    Meng, Fanxing; Li, Shuling; Cao, Lingzhi; Li, Musen; Peng, Qijia; Wang, Chunhui; Zhang, Wei

    2015-01-01

    Fatigue among truck drivers has been studied extensively; however, less is known regarding the fatigue experience of taxi drivers in heavily populated metropolitan areas. This study aimed to compare the differences and similarities between truck and taxi driver fatigue to provide implications for the fatigue management and education of professional drivers. A sample of 274 truck drivers and 286 taxi drivers in Beijing was surveyed via a questionnaire, which included items regarding work characteristics, fatigue experience, accident information, attitude toward fatigue, and methods of counteracting fatigue. Driver fatigue was prevalent among professional drivers, and it was even more serious for taxi drivers. Taxi drivers reported more frequent fatigue experiences and were involved in more accidents. Among the contributing factors to fatigue, prolonged driving time was the most important factor identified by both driver groups. Importantly, the reason for the engagement in prolonged driving was neither due to the lack of awareness concerning the serious outcome of fatigue driving nor because of their poor detection of fatigue. The most probable reason was the optimism bias, as a result of which these professional drivers thought that fatigue was more serious for other drivers than for themselves, and they thought that they were effective in counteracting the effect of fatigue on their driving performance. Moreover, truck drivers tended to employ methods that require stopping to counteract fatigue, whereas taxi drivers preferred methods that were simultaneous with driving. Although both driver groups considered taking a nap as one of the most effective means to address fatigue, this method was not commonly used. Interestingly, these drivers were aware that the methods they frequently used were not the most effective means to counteract fatigue. This study provides knowledge on truck and taxi drivers' characteristics in fatigue experience, fatigue attitude, and

  11. Assessment of early onset of driver fatigue using multimodal fatigue measures in a static simulator.

    Science.gov (United States)

    Jagannath, M; Balasubramanian, Venkatesh

    2014-07-01

    Driver fatigue is an important contributor to road accidents. This paper reports a study that evaluated driver fatigue using multimodal fatigue measures, i.e., surface electromyography (sEMG), electroencephalography (EEG), seat interface pressure, blood pressure, heart rate and oxygen saturation level. Twenty male participants volunteered in this study by performing 60 min of driving on a static simulator. Results from sEMG showed significant physical fatigue (ρ fatigue. This will help us understand the influence of physical and mental fatigue on driver during monotonous driving. Copyright © 2014 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  12. Atrial fibrillation driver mechanisms: Insight from the isolated human heart.

    Science.gov (United States)

    Csepe, Thomas A; Hansen, Brian J; Fedorov, Vadim V

    2017-01-01

    Although there have been great technological advances in the treatment of atrial fibrillation (AF), current therapies remain limited due to a narrow understanding of AF mechanisms in the human heart. This review will highlight our recent studies on explanted human hearts where we developed and employed a novel functional-structural mapping approach by integrating high-resolution simultaneous endo-epicardial and panoramic optical mapping with 3D gadolinium-enhanced MRI to define the spatiotemporal characteristics of AF drivers and their structural substrates. The results allow us to postulate that the primary mechanism of AF maintenance in human hearts is a limited number of localized intramural microanatomic reentrant AF drivers anchored to heart-specific 3D fibrotically insulated myobundle tracks, which may remain hidden to clinical single-surface electrode mapping. We suggest that ex vivo human heart studies, by using an integrated 3D functional and structural mapping approach, will help to reveal defining features of AF drivers as well as validate and improve clinical approaches to detect and target these AF drivers in patients with cardiac diseases. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Dominant drivers of business students

    Directory of Open Access Journals (Sweden)

    Radu Cătălina

    2017-07-01

    Full Text Available Taibi Kahler wrote in 1974 a theory about five main drivers that could explain people’s motivation and a series of positive and negative behavior patterns: Be Strong, Be Perfect, Hurry Up, Try Hard and Please People. Of course, we consider there is no absolute positive or negative behavior, since (1 everything needs to be analyzed by taking into account the context and (2 any behavior pattern can mean a series of advantages as long as people understand their own values, beliefs, attitudes and behaviors. It would be interesting to link Kahler’s drivers to the educational process, in order to be able to adapt our courses and our teaching styles to students’ requirements and also to the requirements in the labor market. Our paper is built on literature review and a questionnaire applied to a sample of 607 students in Bucharest University of Economic Studies, Romania. Information was processed with Microsoft Excel 2013, in order to look at the main working styles our students have, at the main explanations for the differences between them and in order to test a series of hypotheses. We were interested to look at the main traits of the current generation of students in our university: dominant drivers, roles of managers and specialists, the attractiveness of the entrepreneurial career path, etc. and at a series of patterns (i.e. gender-related differences. We consider results of this study are useful both for teaching and research purposes. In terms of teaching, we plan to adapt our educational methods in order to improve the educational process.

  14. Mass drivers. 1: Electrical design

    Science.gov (United States)

    Arnold, W.; Bowen, S.; Fine, K.; Kaplan, D.; Kolm, M.; Kolm, H.; Newman, J.; Oneill, G. K.; Snow, W.

    1979-01-01

    A mass driver is an electrical device used to accelerate payloads of any material to a high velocity. Small vehicles (called buckets) containing superconducting coils carry the payloads. These buckets are accelerated by pulsed magnetic fields, timed by information on their position, and are guided by induced magnetic fields set up in a surrounding guideway. Upon reaching the correct velocity, the buckets release their payloads, then they are slowed for recirculation to be reused. A rationale is presented that leads to a relatively simple and near-optimum design, as well as basic programs for calculating acceleration. The transverse oscillation frequencies are found to be invariant to guideway transverse dimensions.

  15. Recent developments in mass drivers

    Science.gov (United States)

    Oneill, G. K.

    1981-01-01

    In the past eight months a new mass driver concept has been explored through calculation and inductance model verification. It retains the linear synchronous principle and freedom from arcs, plasmas or physical contact between the accelerated bucket and accelerator. However, it discards passive magnetic flight and obtains transverse focussing from strong off-axis restoring forces produced by drive coils operating in a pull-only mode. This paper gives the reasoning on which the new concept is based, and applies the concept to a lunar catapult design.

  16. Drivers of sustainable future mobility

    DEFF Research Database (Denmark)

    Sigurdardottir, Sigrun Birna

    by bicycle were related to positive cycling experience, willingness to accept car restrictions, negative attitudes towards cars, and bicycle-oriented future vision, but are negatively related to car ownership norms. Attitudinal constructs are related to individual characteristics, such as gender, residential...... the semantic content of the data, to create a data driven conceptual model. Three segments of pre-drivers were identified: car enthusiasts, who would like to be early car users, car pragmatists, who would like to have the license at an early stage and a car at a later stage, and car sceptics, who are late...

  17. Nonmagnetic driver for piezoelectric actuators

    DEFF Research Database (Denmark)

    Ekhtiari, Marzieh

    2014-01-01

    Piezoelectric actuator drive aims to enable reliable motor performance in strong magnetic fields for magnetic res- onance imaging and computed tomography treatment tables. There are technical limitations in operation of these motors and drive systems related to magnetic interference. Piezoelectric...... actuators. Therefore, piezoelectric transformer-based power converters are used for driving piezoelectric actuator drive motor in the presence of high electromagnetic field....... actuator drive is the only form-fit continuous drive solution currently available for the development of high performance nonmagnetic motors. In this research focus will be on the non magnetic compact high efficiency driver for the piezo actuators and on employing energy recovery from the capacitive...

  18. Monitoring Car Drivers' Condition Using Image Processing

    Science.gov (United States)

    Adachi, Kazumasa; Yamamto, Nozomi; Yamamoto, Osami; Nakano, Tomoaki; Yamamoto, Shin

    We have developed a car driver monitoring system for measuring drivers' consciousness, with which we aim to reduce car accidents caused by drowsiness of drivers. The system consists of the following three subsystems: an image capturing system with a pulsed infrared CCD camera, a system for detecting blinking waveform by the images using a neural network with which we can extract images of face and eye areas, and a system for measuring drivers' consciousness analyzing the waveform with a fuzzy inference technique and others. The third subsystem extracts three factors from the waveform first, and analyzed them with a statistical method, while our previous system used only one factor. Our experiments showed that the three-factor method we used this time was more effective to measure drivers' consciousness than the one-factor method we described in the previous paper. Moreover, the method is more suitable for fitting parameters of the system to each individual driver.

  19. Risk factors affecting fatal bus accident severity: Their impact on different types of bus drivers.

    Science.gov (United States)

    Feng, Shumin; Li, Zhenning; Ci, Yusheng; Zhang, Guohui

    2016-01-01

    While the bus is generally considered to be a relatively safe means of transportation, the property losses and casualties caused by bus accidents, especially fatal ones, are far from negligible. The reasons for a driver to incur fatalities are different in each case, and it is essential to discover the underlying risk factors of bus fatality severity for different types of drivers in order to improve bus safety. The current study investigates the underlying risk factors of fatal bus accident severity to different types of drivers in the U.S. by estimating an ordered logistic model. Data for the analysis are retrieved from the Buses Involved in Fatal Accidents (BIFA) database from the USA for the years 2006-2010. Accidents are divided into three levels by counting their equivalent fatalities, and the drivers are classified into three clusters by the K-means cluster analysis. The analysis shows that some risk factors have the same impact on different types of drivers, they are: (a) season; (b) day of week; (c) time period; (d) number of vehicles involved; (e) land use; (f) manner of collision; (g) speed limit; (h) snow or ice surface condition; (i) school bus; (j) bus type and seating capacity; (k) driver's age; (l) driver's gender; (m) risky behaviors; and (n) restraint system. Results also show that some risk factors only have impact on the "young and elder drivers with history of traffic violations", they are: (a) section type; (b) number of lanes per direction; (c) roadway profile; (d) wet road surface; and (e) cyclist-bus accident. Notably, history of traffic violations has different impact on different types of bus drivers. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Mass Driver Two - A status report

    Science.gov (United States)

    Snow, W. R.; Dunbar, R. S.; Kubby, J. A.; Oneill, G. K.

    1982-01-01

    The current status of Mass Driver Two, a linear synchronous motor for accelerating payloads or reaction mass, is discussed. Mass Driver Two combines all the essential elements of an operational mass driver with the exception of bucket recirculation and payload handling. These essential elements include: magnetic flight, vacuum environment, superconducting bucket coils, high acceleration (nominally 500 g's), optical position sensing and electronic triggering, power circuitry similar to that of a flight article, and regenerative braking. Mass Driver Two is operated on a single shot basis.

  1. Effect of freeway level of service and driver education on truck driver stress : phase 1.

    Science.gov (United States)

    2012-08-01

    This research primarily deals with truck driver stress and its nature, stressors, and their mutual relationship. During the : study, the different demands of driving that are related to roads, vehicle, traffic conditions, driver predisposition to : s...

  2. Driving experiences of disabled drivers.

    Science.gov (United States)

    Prasad, R S; Hunter, J; Hanley, J

    2006-05-01

    To study the influence of non-standard controls on return to driving after disability, including prevalence of accidents/retraining difficulties. Postal questionnaires sent within two years of assessment to 972 disabled drivers seen over a three-year period. Scottish Driving Assessment Service. All patients considered capable of driving after assessment during the study period. Five hundred and eighty-nine people (61 %) replied who were representative of the total population (mean age 55 years, range 19-87); 73% were male and 70% were disabled for up to two years. Overall 79% respondents had returned to driving (highest reported success with standard manual car (86%) and lowest using left foot to accelerate and brake (66%) (chi2 = 16.6, P = 0.005)). A significantly higher proportion of the 30 patients (6.5%) admitting to accidents and 25 (5.4%) to problems with retraining were using non-standard driving techniques, especially the use of hand controls. Disabled drivers returning to drive using non-familiar controls had lower success and a higher proportion of accidents and/or problems with retraining than people using conventional controls. If confirmed in larger studies this may have implications for policy-makers as well as specialist practitioners.

  3. Factors associated with self-reported driver sleepiness and incidents in city bus drivers

    NARCIS (Netherlands)

    Anund, A.; Ihlström, J.; Fors, C.; Kecklund, L.G.; Filtness, A.J.

    2016-01-01

    Driver fatigue has received increased attention during recent years and is now considered to be a major contributor to approximately 15-30% of all crashes. However, little is known about fatigue in city bus drivers. It is hypothesized that city bus drivers suffer from sleepiness, which is due to a

  4. Driver Anger Scale (DAS Among Car Drivers: How Serious Are They?

    Directory of Open Access Journals (Sweden)

    Ambak Kamarudin

    2017-01-01

    Full Text Available Nowadays, anger while driving on the road is a crucial issue in Malaysia. The anger of driver may lead to traffic crashes. Road accident issue is an important agenda in every country. Driver behaviour and attitude such as impatience, hasty and hot-tempered on the road has become one of the causes in road accidents. Uncontrolled anger will affect the behavior of oneself during driving and could cause an individual to display aggressive attitude. Therefore, this study is aimed to identify contributing factor in anger of drivers and evaluate the Driver Anger Scale (DAS in Batu Pahat, Johor. In addition, this study also analyzes the relationship between driver anger and the factor of DAS. Cross sectional study method was conducted in this study by distributing 250 questionnaires to car drivers. The data collectied was analyzed by descriptive, chi-square test, correlation and regression analysis using Statistical Package for Social Sciences (SPSS version 20.0. The findings show that the discourtesy was reported as the most dominant factor contributing to driver anger. As a recommendation, to overcome driver anger issue, the authorities should prepare an action plan, promote and nurture public to practice good driving behaviour. Moreover, curriculum and driver training lesson should be improved to create better attitude among drivers. Drivers also should change their driving attitude by becoming safe drivers and exhibiting defensive driving skills on the road.

  5. Prediction of Driver's Intention of Lane Change by Augmenting Sensor Information Using Machine Learning Techniques.

    Science.gov (United States)

    Kim, Il-Hwan; Bong, Jae-Hwan; Park, Jooyoung; Park, Shinsuk

    2017-06-10

    Driver assistance systems have become a major safety feature of modern passenger vehicles. The advanced driver assistance system (ADAS) is one of the active safety systems to improve the vehicle control performance and, thus, the safety of the driver and the passengers. To use the ADAS for lane change control, rapid and correct detection of the driver's intention is essential. This study proposes a novel preprocessing algorithm for the ADAS to improve the accuracy in classifying the driver's intention for lane change by augmenting basic measurements from conventional on-board sensors. The information on the vehicle states and the road surface condition is augmented by using an artificial neural network (ANN) models, and the augmented information is fed to a support vector machine (SVM) to detect the driver's intention with high accuracy. The feasibility of the developed algorithm was tested through driving simulator experiments. The results show that the classification accuracy for the driver's intention can be improved by providing an SVM model with sufficient driving information augmented by using ANN models of vehicle dynamics.

  6. Exploring drivers of wetland hydrologic fluxes across parameters and space

    Science.gov (United States)

    Jones, C. N.; Cheng, F. Y.; Mclaughlin, D. L.; Basu, N. B.; Lang, M.; Alexander, L. C.

    2017-12-01

    Depressional wetlands provide diverse ecosystem services, ranging from critical habitat to the regulation of landscape hydrology. The latter is of particular interest, because while hydrologic connectivity between depressional wetlands and downstream waters has been a focus of both scientific research and policy, it remains difficult to quantify the mode, magnitude, and timing of this connectivity at varying spatial and temporary scales. To do so requires robust empirical and modeling tools that accurately represent surface and subsurface flowpaths between depressional wetlands and other landscape elements. Here, we utilize a parsimonious wetland hydrology model to explore drivers of wetland water fluxes in different archetypal wetland-rich landscapes. We validated the model using instrumented sites from regions that span North America: Prairie Pothole Region (south-central Canada), Delmarva Peninsula (Mid-Atlantic Coastal Plain), and Big Cypress Swamp (southern Florida). Then, using several national scale datasets (e.g., National Wetlands Inventory, USFWS; National Hydrography Dataset, USGS; Soil Survey Geographic Database, NRCS), we conducted a global sensitivity analysis to elucidate dominant drivers of simulated fluxes. Finally, we simulated and compared wetland hydrology in five contrasting landscapes dominated by depressional wetlands: prairie potholes, Carolina and Delmarva bays, pocosins, western vernal pools, and Texas coastal prairie wetlands. Results highlight specific drivers that vary across these regions. Largely, hydroclimatic variables (e.g., PET/P ratios) controlled the timing and magnitude of wetland connectivity, whereas both wetland morphology (e.g., storage capacity and watershed size) and soil characteristics (e.g., ksat and confining layer depth) controlled the duration and mode (surface vs. subsurface) of wetland connectivity. Improved understanding of the drivers of wetland hydrologic connectivity supports enhanced, region

  7. Vehicle and driver scheduling for public transit.

    Science.gov (United States)

    2009-08-01

    The problem of driver scheduling involves the construction of a legal set of shifts, including allowance : of overtime, which cover the blocks in a particular vehicle schedule. A shift is the work scheduled to be performed by : a driver in one day, w...

  8. Cedar Avenue driver assist system evaluation report.

    Science.gov (United States)

    2011-12-01

    This paper summarizes an evaluation of the Driver Assist System (DAS) used by the Minnesota Valley Transit Authority (MTVA) for bus shoulder operations. The DAS is a GPS-based technology suite that provides lane-position feedback to the driver via a ...

  9. Functional Bus Driver-Pupil Passenger Relationships.

    Science.gov (United States)

    Farmer, Ernest

    1987-01-01

    Successful school bus drivers bring much more than mechanical know-how to the job. They develop good rapport with students while acting to bring undesirable student behavior under control. Drivers must also show an interest in students' welfare and have a good sense of humor. (MLH)

  10. Traffic Safety through Driver Assistance and Intelligence

    Directory of Open Access Journals (Sweden)

    Heiner Bubb

    2011-05-01

    BMW, Daimler, Audi, Citroen, Lexus, VW, Opel, Peugeot, Renault, Chevrolet, Saab and Bosch. Both the contributions of research work concerning driving behavior analysis and driver assistance systems have to be aligned with a permanently updated interaction within the system of driver, vehicle and road traffic environment.

  11. Impact Driver With Integral Sliding Hammer

    Science.gov (United States)

    Wallace, Bilby J.

    1987-01-01

    Tool combines impact driver with sliding dead-blow hammer. Used for any purpose for which ordinary impact driver used; tightening fasteners or driving starter holes for drill. Tool protects user from accidental injury and surrounding equipment from damage that might occur from ordinary arm-wielded hammer. Especially useful in underwater work.

  12. Physics at an upgraded Fermilab proton driver

    Energy Technology Data Exchange (ETDEWEB)

    Geer, S.; /Fermilab

    2005-07-01

    In 2004 the Fermilab Long Range Planning Committee identified a new high intensity Proton Driver as an attractive option for the future, primarily motivated by the recent exciting developments in neutrino physics. Over the last few months a physics study has developed the physics case for the Fermilab Proton Driver. The potential physics opportunities are discussed.

  13. 49 CFR 177.816 - Driver training.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Driver training. 177.816 Section 177.816... Information and Regulations § 177.816 Driver training. (a) In addition to the training requirements of § 177... employee who will operate a motor vehicle has been trained in the applicable requirements of 49 CFR parts...

  14. Driver citation/carrier data relationship project

    Science.gov (United States)

    1996-09-01

    The Driver/Carrier Relationship Project was commissioned to address three issues. The first was to determine if drivers of commercial motor vehicles get tickets at a different rate, depending on the carrier that they are working for. The second issue...

  15. Driver electronic device use in 2013.

    Science.gov (United States)

    2015-04-01

    The percentage of drivers text-messaging or visibly manipulating : hand-held devices increased from 1.5 percent in : 2012 to 1.7 percent in 2013; however, this was not a statistically : significant increase. Driver hand-held cell phone : use decrease...

  16. Frictional Dermatosis in a Courier Driver

    OpenAIRE

    Wollina, Uwe; Tchernev, Georgi; Lotti, Torello

    2017-01-01

    Frictional hypermelanosis is an uncommon finding in Caucasians. We report the unusual case of 56-year-old male courier driver who developed linear and patchy hypermelanosis of the back caused by the driver's seat. Histology has included other pathologies. Treatment of the asymptomatic hyper pigmentation was not warranted.

  17. About Assessment Criteria of Driver's Accidental Abilities

    Science.gov (United States)

    Lobanova, Yuliya I.; Glushko, Kirill V.

    2016-01-01

    The article points at the importance of studying the human factor as a cause of accidents of drivers, especially in loosely structured traffic situations. The description of the experiment on the measurement of driver's accidental abilities is given. Under accidental ability is meant the capability to ensure the security of driving as a behavior…

  18. BDC 500 branch driver controller

    CERN Document Server

    Dijksman, A

    1981-01-01

    This processor has been designed for very fast data acquisition and date pre-processing. The dataway and branch highway speeds have been optimized for approximately 1.5 mu sec. The internal processor cycle is approximately 0.8 mu sec. The standard version contains the following functions (slots): crate controller type A1; branch highway driver including terminator; serial I/O port (TTY, VDU); 24 bit ALU and 24 bit program counter; 16 bit memory address counter and 4 word stack; 4k bit memory for program and/or data; battery backup for the memory; CNAFD and crate LAM display; request/grant logic for time- sharing operation of several BDCs. The free slots can be equipped with e.g. extra RAM, computer interfaces, hardware multiplier/dividers, etc. (0 refs).

  19. The drivers of plant diversity

    DEFF Research Database (Denmark)

    Jensen, Kristine Engemann

    , and these results highlight that even large-scale vegetation patterns can be influenced by climate change and anthropogenic pressures. In Paper III we investigate how sampling bias in botanical dataset can influence patterns of species richness and parameter estimation from statistical analyses. We test...... moredistinct. Climate change, forest fires, and forest loss were identified as the most important drivers of forest alpha and beta diversity change over time. In Paper VI we utilize a new concept in community ecology, dark diversity, to quantify the effect of present and historical environmental factors...... on species diversity in the European Alps using monitoring data from the Alps Vegetation Database. We identified grassland and rocky habitats to have the highest dark diversity intensified by high human influence. We conclude that dark diversity is a valuable conservation tool that can guide conservation...

  20. High-acceleration mass drivers

    Science.gov (United States)

    Oneill, G. K.; Kolm, H. H.

    1979-01-01

    High-acceleration mass drivers are discussed including the MD2 model of axial geometry, with individually powered drive coils of 13.1 cm diameter. Timing is derived through the interruption of light beams by the moving armature (bucket). Electric power is provided by the resonant discharge of sector capacitor banks through silicon-controlled rectifiers in a two-phase, quadrature circuit. The bucket flies in vacuum, guided by passive dynamic eddy-current magnetic forces, those currents flowing in strip conductors lining the inside of a nonconducting vacuum pipe. Quantitative measurements are obtained with a solid bucket carrying two superconducting coils with a current density of 25 kA/sq cm. A cryogenic station for cooling the bucket to liquid helium temperature is connected to the vacuum pipe.

  1. Square pulse linear transformer driver

    Science.gov (United States)

    Kim, A. A.; Mazarakis, M. G.; Sinebryukhov, V. A.; Volkov, S. N.; Kondratiev, S. S.; Alexeenko, V. M.; Bayol, F.; Demol, G.; Stygar, W. A.

    2012-04-01

    The linear transformer driver (LTD) technological approach can result in relatively compact devices that can deliver fast, high current, and high-voltage pulses straight out of the LTD cavity without any complicated pulse forming and pulse compression network. Through multistage inductively insulated voltage adders, the output pulse, increased in voltage amplitude, can be applied directly to the load. The usual LTD architecture [A. A. Kim, M. G. Mazarakis, V. A. Sinebryukhov, B. M. Kovalchuk, V. A. Vizir, S. N Volkov, F. Bayol, A. N. Bastrikov, V. G. Durakov, S. V. Frolov, V. M. Alexeenko, D. H. McDaniel, W. E. Fowler, K. LeCheen, C. Olson, W. A. Stygar, K. W. Struve, J. Porter, and R. M. Gilgenbach, Phys. Rev. ST Accel. Beams 12, 050402 (2009)PRABFM1098-440210.1103/PhysRevSTAB.12.050402; M. G. Mazarakis, W. E. Fowler, A. A. Kim, V. A. Sinebryukhov, S. T. Rogowski, R. A. Sharpe, D. H. McDaniel, C. L. Olson, J. L. Porter, K. W. Struve, W. A. Stygar, and J. R. Woodworth, Phys. Rev. ST Accel. Beams 12, 050401 (2009)PRABFM1098-440210.1103/PhysRevSTAB.12.050401] provides sine shaped output pulses that may not be well suited for some applications like z-pinch drivers, flash radiography, high power microwaves, etc. A more suitable power pulse would have a flat or trapezoidal (rising or falling) top. In this paper, we present the design and first test results of an LTD cavity that generates such a type of output pulse by including within its circular array a number of third harmonic bricks in addition to the main bricks. A voltage adder made out of a square pulse cavity linear array will produce the same shape output pulses provided that the timing of each cavity is synchronized with the propagation of the electromagnetic pulse.

  2. Stability analysis of automobile driver steering control

    Science.gov (United States)

    Allen, R. W.

    1981-01-01

    In steering an automobile, the driver must basically control the direction of the car's trajectory (heading angle) and the lateral deviation of the car relative to a delineated pathway. A previously published linear control model of driver steering behavior which is analyzed from a stability point of view is considered. A simple approximate expression for a stability parameter, phase margin, is derived in terms of various driver and vehicle control parameters, and boundaries for stability are discussed. A field test study is reviewed that includes the measurement of driver steering control parameters. Phase margins derived for a range of vehicle characteristics are found to be generally consistent with known adaptive properties of the human operator. The implications of these results are discussed in terms of driver adaptive behavior.

  3. Reducing risky driver behaviour through the implementation of a driver risk management system

    Directory of Open Access Journals (Sweden)

    Rose Luke

    2014-11-01

    Full Text Available South Africa has one of the highest incidences of road accidents in the world. Most accidents are avoidable and are caused by driver behaviour and errors. The purpose of this article was to identify the riskiest driver behaviours in commercial fleets in South Africa, to determine the business impact of such behaviour, to establish a framework for the management of risky driver behaviour and to test the framework by applying a leading commercial driver behaviour management system as a case study. The case study comprised three South African commercial fleets. Using data from these fleets, critical incident triangles were used to determine the ratio data of risky driver behaviour to near-collisions and collisions. Based on managing the riskiest driver behaviours as causes of more serious incidents and accidents, the results indicated that through the implementation of an effective driver risk management system, risky incidents were significantly reduced.

  4. Driver drowsiness detection using multimodal sensor fusion

    Science.gov (United States)

    Andreeva, Elena O.; Aarabi, Parham; Philiastides, Marios G.; Mohajer, Keyvan; Emami, Majid

    2004-04-01

    This paper proposes a multi-modal sensor fusion algorithm for the estimation of driver drowsiness. Driver sleepiness is believed to be responsible for more than 30% of passenger car accidents and for 4% of all accident fatalities. In commercial vehicles, drowsiness is blamed for 58% of single truck accidents and 31% of commercial truck driver fatalities. This work proposes an innovative automatic sleep-onset detection system. Using multiple sensors, the driver"s body is studied as a mechanical structure of springs and dampeners. The sleep-detection system consists of highly sensitive triple-axial accelerometers to monitor the driver"s upper body in 3-D. The subject is modeled as a linear time-variant (LTV) system. An LMS adaptive filter estimation algorithm generates the transfer function (i.e. weight coefficients) for this LTV system. Separate coefficients are generated for the awake and asleep states of the subject. These coefficients are then used to train a neural network. Once trained, the neural network classifies the condition of the driver as either awake or asleep. The system has been tested on a total of 8 subjects. The tests were conducted on sleep-deprived individuals for the sleep state and on fully awake individuals for the awake state. When trained and tested on the same subject, the system detected sleep and awake states of the driver with a success rate of 95%. When the system was trained on three subjects and then retested on a fourth "unseen" subject, the classification rate dropped to 90%. Furthermore, it was attempted to correlate driver posture and sleepiness by observing how car vibrations propagate through a person"s body. Eight additional subjects were studied for this purpose. The results obtained in this experiment proved inconclusive which was attributed to significant differences in the individual habitual postures.

  5. Parent-taught driver education in Texas : a comparative evaluation

    Science.gov (United States)

    2007-04-01

    An evaluation of the Parent-Taught Driver Education (PTDE) program in Texas was conducted using three different research techniques: (1) focus groups with driver education instructors, teen drivers, and their parents; (2) statewide mail survey of you...

  6. Square pulse linear transformer driver

    Directory of Open Access Journals (Sweden)

    A. A. Kim

    2012-04-01

    Full Text Available The linear transformer driver (LTD technological approach can result in relatively compact devices that can deliver fast, high current, and high-voltage pulses straight out of the LTD cavity without any complicated pulse forming and pulse compression network. Through multistage inductively insulated voltage adders, the output pulse, increased in voltage amplitude, can be applied directly to the load. The usual LTD architecture [A. A. Kim, M. G. Mazarakis, V. A. Sinebryukhov, B. M. Kovalchuk, V. A. Vizir, S. N Volkov, F. Bayol, A. N. Bastrikov, V. G. Durakov, S. V. Frolov, V. M. Alexeenko, D. H. McDaniel, W. E. Fowler, K. LeCheen, C. Olson, W. A. Stygar, K. W. Struve, J. Porter, and R. M. Gilgenbach, Phys. Rev. ST Accel. Beams 12, 050402 (2009PRABFM1098-440210.1103/PhysRevSTAB.12.050402; M. G. Mazarakis, W. E. Fowler, A. A. Kim, V. A. Sinebryukhov, S. T. Rogowski, R. A. Sharpe, D. H. McDaniel, C. L. Olson, J. L. Porter, K. W. Struve, W. A. Stygar, and J. R. Woodworth, Phys. Rev. ST Accel. Beams 12, 050401 (2009PRABFM1098-440210.1103/PhysRevSTAB.12.050401] provides sine shaped output pulses that may not be well suited for some applications like z-pinch drivers, flash radiography, high power microwaves, etc. A more suitable power pulse would have a flat or trapezoidal (rising or falling top. In this paper, we present the design and first test results of an LTD cavity that generates such a type of output pulse by including within its circular array a number of third harmonic bricks in addition to the main bricks. A voltage adder made out of a square pulse cavity linear array will produce the same shape output pulses provided that the timing of each cavity is synchronized with the propagation of the electromagnetic pulse.

  7. SUBJECTIVE METHODS FOR ASSESSMENT OF DRIVER DROWSINESS

    Directory of Open Access Journals (Sweden)

    Alina Mashko

    2017-12-01

    Full Text Available The paper deals with the issue of fatigue and sleepiness behind the wheel, which for a long time has been of vital importance for the research in the area of driver-car interaction safety. Numerous experiments on car simulators with diverse measurements to observe human behavior have been performed at the laboratories of the faculty of the authors. The paper provides analysis and an overview and assessment of the subjective (self-rating and observer rating methods for observation of driver behavior and the detection of critical behavior in sleep deprived drivers using the developed subjective rating scales.

  8. Intelligent Speed Adaptation for involuntary drivers

    DEFF Research Database (Denmark)

    Agerholm, Niels; Tradisauskas, Nerius; Juhl, Jens

    2012-01-01

    and warning, the ISA had an incentive in the form of rewards for speeding avoidance and social control - the latter, however, did not work sufficiently. When a key ID was used, the proportion of speeding was low while driving with ISA. Without key ID there was virtually no change in driving behaviour...... regardless of ISA. Also, a statistical model showed that drivers sensitive to ISA sped significantly less in baseline than insensitive dri- vers. Moreover, on the basis of questionnaires it was found that drivers could be categorised as either green drivers (not positive to speeding) or red (more positive...

  9. Optimizing the Universal Robots ROS driver

    DEFF Research Database (Denmark)

    Andersen, Thomas Timm

    In this report I will examine both the current and the possible performance of one of the most popular robotics platforms in research, the Universal Robot manipulator. I will solely focus on the ROS based approaches and show how the current driver can be improved. I will look at performance...... improvement both in terms of faster reaction as well as making it possible to control the robot using either ros_control or ordinary joint speed commands, which is required for many types of sensory based control like visual servoing. The developed driver is compared to the drivers already existing in the ROS...

  10. Camera-based driver assistance systems

    Science.gov (United States)

    Grimm, Michael

    2013-04-01

    In recent years, camera-based driver assistance systems have taken an important step: from laboratory setup to series production. This tutorial gives a brief overview on the technology behind driver assistance systems, presents the most significant functionalities and focuses on the processes of developing camera-based systems for series production. We highlight the critical points which need to be addressed when camera-based driver assistance systems are sold in their thousands, worldwide - and the benefit in terms of safety which results from it.

  11. Tarantula: Killing driver bugs before they hatch

    DEFF Research Database (Denmark)

    Lawall, Julia Laetitia; Muller, Gilles; Urunuela, Richard

    2005-01-01

    The Linux operating system is undergoing continual evolution. Evolution in the kernel and generic driver modules often triggers the need for corresponding evolutions in specific device drivers. Such collateral evolutions are tedious, because of the large number of device drivers, and error......-prone, because of the complexity of the code modifications involved. We propose an automatic tool, Tarantula, to aid in this process. In this paper, we examine some recent evolutions in Linux and the collateral evolutions they trigger, and assess the corresponding requirements on Tarantula....

  12. Assessing the relationship between the Driver Behavior Questionnaire and the Driver Skill Inventory: Revealing sub-groups of drivers

    DEFF Research Database (Denmark)

    Martinussen, Laila Marianne; Møller, Mette; Prato, Carlo Giacomo

    2014-01-01

    by frequency of aberrant driving behaviors and level of driving skills), as well as to test whether the sub-groups differ in characteristics such as age, gender, annual mileage and accident involvement. Furthermore, the joint analysis of the two instruments was used to test drivers’ assessment of their own...... self-reported driving skills and whether the reported skill level was reflected in the reported aberrant driving behaviors. 3908 drivers aged 18–84 participated in the survey. K-means cluster analysis revealed four distinct sub-groups that differed in driving skills and frequency of aberrant driving......The Driver Behavior Questionnaire and the Driver Skill Inventory are two of the most frequently used measures of self-reported driving style and driving skill. The motivation behind the present study was to identify sub-groups of drivers that potentially act dangerously in traffic (as measured...

  13. Child passengers and driver culpability in fatal crashes by driver gender.

    Science.gov (United States)

    Maasalo, Ida; Lehtonen, Esko; Pekkanen, Jami; Summala, Heikki

    2016-07-03

    Studies based on accident statistics generally suggest that the presence of a passenger reduces adult drivers' accident risk. However, passengers have been reported to be a source of distraction in a remarkable portion of distraction-related crashes. Although the effect of passengers on driving performance has been studied extensively, few studies have focused on how a child passenger affects the driver.  A child in a car is a potential distractor for parents, especially for mothers of small children, who often suffer from sleep deficit. The aim of this study was to examine how the presence of child passengers of different ages is associated with a higher driver culpability, which was expected due to child-related distraction and fatigue. The analysis was based on the comprehensive data of fatal crashes studied in-depth by multidisciplinary road accident investigation teams in Finland during 1988-2012. Teams determine the primary party who had the most crucial effect on the origin of the event. We define the primary party as culpable and the others involved as nonculpable drivers. The culpability rate was defined as the percentage of culpable drivers and rates were compared for drivers with a child/teen passenger aged 0-17 years (N = 348), with an adult passenger without children (N = 324), and when driving alone (N = 579), grouped by child age and driver gender.  Drivers with specific risk-related behavior (substantial speeding, driving when intoxicated, unbelted, or without a license) were excluded from the analyses, in order to make the drivers with and without children comparable. Only drivers 26-47 years old were included, representing parents with children 0-9 years of age. Male drivers were less often culpable with 0- to 17-year-old passengers in the car than alone or with adults. This was not the case with female drivers. The gender difference in culpability was most marked with small children age 0-4 years. Female drivers' culpability rate with a 0

  14. A study of at-fault older drivers in light-vehicle crashes in Singapore.

    Science.gov (United States)

    Chin, Hoong Chor; Zhou, Mo

    2018-03-01

    A number of studies on motor vehicle crashes have suggested that older drivers are more likely to be at-fault compared to younger drivers. The objective of this paper is to identify factors that contribute to older drivers (aged 65 and above) being at fault in light vehicle crashes in Singapore. Based on 3 years of crash data, the calibrated binary logit model shows that older drivers are more likely to be at fault during peak periods and festive seasons between November to February, as well as at gore areas of expressways, intersections. Curb lanes of multi-lane roads and single-lane roads are also found to increase the odds of older drivers being at fault. Furthermore, older drivers appear to have more problems on roads with wet surfaces and speed limits of 60 km/h and 70 km/h. In the light of an aging population in Singapore, it is imperative that more targeted countermeasures be taken from multiple perspectives to lower such risks. Copyright © 2018 Elsevier Ltd. All rights reserved.

  15. Heavy-ion driver parametric studies and choice of a base 5 mega-joule driver design

    International Nuclear Information System (INIS)

    Bieri, R.; Meier, W.

    1992-01-01

    Parametric studies to optimize heavy-ion driver designs are described and an optimized 5 MJ driver design is described. Parametric studies are done on driver parameters including driver energy, number of beams, type of superconductor used in focusing magnets, maximum magnetic field allowed at the superconducting windings, axial quadrupole field packing fraction, ion mass, and ion charge state. All modeled drivers use the maximum beam currents allowed by the Maschke limits; driver scaling is described in a companion paper. The optimized driver described is conservative and cost effective. The base driver direct costs are only $120/Joule, and the base driver uses no recirculation, beam combination, or beam separation. The low driver cost achieved is due, in part, to the use of compact Nb 3 Sn quadrupole arrays, but results primarily from optimization over the large, multi-dimensional, parameter space available for heavy-ion drivers

  16. Driver ASICs for Advanced Deformable Mirrors Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The program leverages on our extensive expertise in developing high-performance driver ASICs for deformable mirror systems and seeks to expand the capacities of the...

  17. Linear Transformer Drivers for Propulsion and Power

    Data.gov (United States)

    National Aeronautics and Space Administration — Explore a variant of the linear transformer driver (LTD) concept being developed by Sandia Laboratories and University of Michigan, with the following differences:...

  18. Drug involvement of fatally injured drivers

    Science.gov (United States)

    2010-11-01

    While data focusing on the danger of driving under the influence : of alcohol is readily available and often cited, less is : known or discussed about drivers under the influence of : other drugs. The Fatality Analysis Reporting System (FARS), : a ce...

  19. The importance of sight for drivers

    Directory of Open Access Journals (Sweden)

    Alicja Pas-Wyroślak

    2013-06-01

    Full Text Available Sight is the basic sense for drivers. Condition of the eye determines correct, comfortable and safe performance of the work as drivers. This article presents various factors influencing the sight condition. There are two groups of factors, external (environment, the kind and time of work, stress caused by work and internal (systemic and local disorders. All these factors can reduce significantly visual functions, such as visual acuity, field of vision, color vision, strereoscopic vision, twilight vision and glare sensitivity. There are also presented actual requirements for drivers and causes of the car accidents in various age groups. Impairments in vision functions can be dangerous for both the driver and other road users. Med Pr 2013;64(3:419–425

  20. Administration of Driver and Traffic Safety Education.

    Science.gov (United States)

    Huffman, Warren J.; Thompson, Adelbert F.

    1981-01-01

    Several arguments for and against driver education and safety programs in the schools are summarized. The validity of the statistics used by opponents is questioned and evidence in support of such programs are outlined. (JMF)

  1. Understanding & modeling bus transit driver availability.

    Science.gov (United States)

    2014-07-01

    Bus transit agencies are required to hire extraboard (i.e. back-up) operators to account for unexpected absences. Incorrect sizing of extra driver workforce is problematic for a number of reasons. Overestimating the appropriate number of extraboard o...

  2. Symbol signing design for older drivers

    Science.gov (United States)

    1997-07-01

    This project evaluated the effectiveness of symbol traffic signs for young, middle-aged and elderly drivers. Daytime legibility distance and comprehension of 85 symbols in the Manual on Uniform Traffic Control Devices (MUTCD) were measured. Legibilit...

  3. Understanding Collateral Evolution in Linux Device Drivers

    DEFF Research Database (Denmark)

    Padioleau, Yoann; Lawall, Julia Laetitia; Muller, Gilles

    2006-01-01

    , as any changes in the interfaces exported by the kernel and driver support libraries can trigger a large number of adjustments in dependent drivers. These adjustments, which we refer to as collateral evolutions, may be complex, entailing substantial code reorganizations. As to our knowledge there exist...... no tools to help in this process, collateral evolution is thus time consuming and error prone.In this paper, we present a qualitative and quantitative assessment of collateral evolution in Linux device driver code. We provide a taxonomy of evolutions and collateral evolutions, and use an automated patch......-analysis tool that we have developed to measure the number of evolutions and collateral evolutions that affect device drivers between Linux versions 2.2 and 2.6. In particular, we find that from one version of Linux to the next, collateral evolutions can account for up to 35% of the lines modified in such code....

  4. Driver education program status report : software system.

    Science.gov (United States)

    1981-01-01

    In April of 1980, a joint decision between Research Council personnel and representatives of the Department of Education was reached, and a project was undertaken by the Research Council to provide a software system to process the annual Driver Educa...

  5. Assessing the needs of Delaware's older drivers.

    Science.gov (United States)

    2007-06-01

    In light of Delawares growing population age 60 and older (60+), it is important to plan for the : states projected increase in older drivers. Information from the United States Census Bureau : (2005) indicates that Delaware is projected to hav...

  6. Experimental testing of designated driver cues

    Science.gov (United States)

    2000-07-27

    In theory, the designated-driver concept holds great promise for reducing the incidences of drunk driving. It is simple, inexpensive, almost universally recognized, and generally positively regarded by the U.S. population as a means for avoiding drun...

  7. Driver circuit for solid state light sources

    Science.gov (United States)

    Palmer, Fred; Denvir, Kerry; Allen, Steven

    2016-02-16

    A driver circuit for a light source including one or more solid state light sources, a luminaire including the same, and a method of so driving the solid state light sources are provided. The driver circuit includes a rectifier circuit that receives an alternating current (AC) input voltage and provides a rectified AC voltage. The driver circuit also includes a switching converter circuit coupled to the light source. The switching converter circuit provides a direct current (DC) output to the light source in response to the rectified AC voltage. The driver circuit also includes a mixing circuit, coupled to the light source, to switch current through at least one solid state light source of the light source in response to each of a plurality of consecutive half-waves of the rectified AC voltage.

  8. Availability, Strengths and Limitations of US State Driver?s License Data for Obesity Research

    OpenAIRE

    Littenberg, Benjamin; Lubetkin, Derek

    2016-01-01

    Objectives:?Driver?s license records in the United States typically contain age, sex, height, weight, and home address. By combining the body mass index (calculated from the reported height and weight) and address information, researchers can explore and quantify the relationships between obesity and specific environmental features surrounding the place of residence. We report here our experience obtaining those data and the current state of driver?s license data as an epidemiological resourc...

  9. Global account management strategies: Drivers and outcomes

    OpenAIRE

    Linda Hui Shi; J Chris White; Shaoming Zou; S Tamer Cavusgil

    2010-01-01

    Global account management (GAM) has become a vital part of many multinational enterprises’ global marketing. Yet little is known about successful GAM strategies. In this study, we conceptualize GAM strategies, and develop and empirically test an integrated theoretical model that links GAM strategies to their drivers and outcomes. We find that: (1) global strategic priority and globalization are significant drivers of four GAM strategies – inter-country coordination, inter-organizational coord...

  10. Vehicle Dynamics Approach to Driver Warning

    OpenAIRE

    Ghoneim, Youssef A.

    2013-01-01

    This paper discusses a concept for enhanced active safety by introducing a driver warning system based on vehicle dynamics that predicts a potential loss of control condition prior to stability control activation. This real-time warning algorithm builds on available technologies such as the Electronic Stability Control (ESC). The driver warning system computes several indices based on yaw rate, side-slip velocity, and vehicle understeer using ESC sensor suite. An arbitrator block arbitrates b...

  11. Electron cloud considerations for HIF drivers

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, R.H., E-mail: rhcohen@lbl.gov [Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94550 (United States); Heavy Ion Fusion Science Virtual National Laboratory (United States)

    2014-01-01

    We review some previous results on electron-cloud dynamics and accumulation and the impact of electron clouds on ion beam dynamics, and assess these in the context of a magnetic-quadrupole-based heavy-ion fusion driver. We present a new analysis which exploits analytic solution of linearized envelope equations between accelerating gaps to derive a set of mapping equations which we use to extrapolate from previously obtained particle-simulation results for a beam transport system to an HIF driver.

  12. Drugged drivers in Norway with benzodiazepine detections.

    Science.gov (United States)

    Skurtveit, Svetlana; Abotnes, Bjørg; Christophersen, Asbjørg S

    2002-01-24

    Norwegian drugged drivers with benzodiazepine (BZD) detections have been studied with regard to drug use pattern and rearrest rate. During 1995, 3343 drivers were apprehended by the police in Norway due to the suspicion of influence by drugs. Blood samples from all drivers were sent to the National Institute of Forensic Toxicology (NIFT). The samples were analysed using a standard program covering the most commonly abused drugs on the marked in Norway. BZDs, representing some of the most frequently detected drugs, were found in approximately 30% (n = 1051) of the cases, represented by 14% (n = 150) female and 86% (n = 901) male drivers. In 8% of the cases, one BZD only was detected, half of these cases with one BZD could reflect therapeutic use. One or more BZDs were combined with illegal drug(s) (73%), other prescribed drugs (10%), and/or alcohol (24%). 62% of the drivers with BZD detections, had earlier been arrested for the same offence, or six cases per rearrested driver. The frequency of earlier arrests were lower for female (34%) than for male (67%) drivers. Alcohol was most frequently found for those arrested for the first time before 1992, while BZD or illegal drugs were most frequently found for those with their first arrest during 1992-1995. Our study shows that apprehended drivers using BZD are mainly represented by drug abusers due to frequent multi-drug use, blood concentrations representing doses above therapeutic levels and high rearrest rate for the same offence. A treatment program or other reactions, are thus necessary in addition to fines, prison penalty and suspension of driving licence.

  13. Physics at a New Fermilab Proton Driver

    OpenAIRE

    Geer, S.

    2006-01-01

    In 2004, motivated by the recent exciting developments in neutrino physics, the Fermilab Long Range Planning Committee identified a new high intensity Proton Driver as an attractive option for the future. At the end of 2004 the APS ``Study on the Physics of Neutrinos'' concluded that the future U.S. neutrino program should have, as one of its components, ``A proton driver in the megawatt class or above and neutrino superbeam with an appropriate very large detector capable of observing CP viol...

  14. A 21-amino acid peptide from the cysteine cluster II of the family D DNA polymerase from Pyrococcus horikoshii stimulates its nuclease activity which is Mre11-like and prefers manganese ion as the cofactor.

    Science.gov (United States)

    Shen, Yulong; Tang, Xiao-Feng; Yokoyama, Hideshi; Matsui, Eriko; Matsui, Ikuo

    2004-01-01

    Family D DNA polymerase (PolD) is a new type of DNA polymerase possessing polymerization and 3'-5' exonuclease activities. Here we report the characterization of the nuclease activity of PolD from Pyrococcus horikoshii. By site-directed mutagenesis, we verified that the putative Mre11-like nuclease domain in the small subunit (DP1), predicted according to computer analysis and structure inference reported previously, is the catalytic domain. We show that D363, H365 and H454 are the essential residues, while D407, N453, H500, H563 and H565 are critical residues for the activity. We provide experimental evidence demonstrating that manganese, rather than magnesium, is the preferable metal ion for the nuclease activity of PolD. We also show that DP1 alone is insufficient to perform full catalysis, which additionally requires the formation of the PolD complex and manganese ion. We found that a 21 amino acid, subunit-interacting peptide of the sequence from cysteine cluster II of the large subunit (DP2) stimulates the exonuclease activity of DP1 and the internal deletion mutants of PolD lacking the 21-aa sequence. This indicates that the putative zinc finger motif of the cysteine cluster II is deeply involved in the nucleolytic catalysis.

  15. Kampanje mjerenja apsolutnog i relativnog ubrzanja sile teže u „Osnovnoj gravimetrijskoj mreži Bosne i Hercegovine“ : Measurement campaign of absolute and relative gravity in "Basic gravimetric network of Bosnia and Herzegovina"

    Directory of Open Access Journals (Sweden)

    Hasumana Abaza

    2014-12-01

    Full Text Available Mjerenje apsolutnog ubrzanja sile Zemljine teže u Bosni i Hercegovini izvršeno je na četiri stanice, a u okviru projekta “Izgradnja kapaciteta za unapređenje zemljišne administracije i procedura u Bosni i Hercegovini“. Mjerenje relativnog ubrzanja sile Zemljine teže također je završeno u Osnovnoj gravimetrijskoj mreži BiH na 60 tačaka, te je izvršeno povezivanje sa stanicama na kojim je mjereno apsolutno ubrzanje sile teže. Do sada urađen posao je odlična osnova za nastavak radova na regionalnom gravimetrijskom premjeru na putu ka konačnom cilju određivanja geoida za teritoriju BiH. : Absolute gravity measurements in Bosnia and Herzegovina were carried out at four stations within the project "Capacity building for improving land administration and procedures in Bosnia and Herzegovina“ - CILAP. Relative gravity measurements were also completed in the primary gravimetric network of Bosnia and Herzegovina at 60 points, followed by connecting points with absolute gravity data. So far, completed work is an excellent basis for continuing on regional gravity measurements and determining the geoid for the territory of Bosnia and Herzegovina.

  16. Effects of Defensive Vehicle Handling on Novice Driver Safety : Phase 3. Data Analysis and Results

    Science.gov (United States)

    2010-09-01

    This project evaluates the effectiveness of a multistage driver education program for Montanas young : drivers. A total of 347 teenaged drivers who had completed high school driver education agreed to participate. : These drivers were randomly spl...

  17. Important information for drivers in France

    CERN Multimedia

    2012-01-01

    From 1 July 2012, any driver of a motorised road vehicle, excluding two- or three-wheeled vehicles whose engine capacity does not exceed 50cm3, must be in possession of a breathalyser in full working order. With effect from 1 November 2012*, drivers failing to produce a breathalyser run the risk of being served with an 11 euro fine. A breathalyser is used to measure the alcohol content in the motorist's breath. The permissible level of alcohol for drivers is less than 0.5 g of alcohol per litre of blood, or 0.25 mg of alcohol per litre of air exhaled. The obligation to have a breathalyser on board the vehicle also applies to all drivers on the French part of the CERN site. All vehicles belonging to or leased by the Organization must also carry a breathalyser together with all the requisite documentation (cf. Operational Circular No. 4). Drivers of privately owned vehicles can obtain breathalysers from car accessory dealers, service stations or pharmacies, etc. Drivers of vehicles belonging to or l...

  18. Knowledge of Tyre Pressures and Tyre Care among Vehicle Drivers ...

    African Journals Online (AJOL)

    The purpose of this study was to evaluate the knowledge of normal tyre pressures and tyre care among motor vehicle drivers in Benin City. Three hundred and one drivers were interviewed consisting of 273 males and 28 females. There were 100 private and 201 commercial drivers. Of the 100 private drivers 67 use brand ...

  19. Workshop on transport for a common ion driver

    Energy Technology Data Exchange (ETDEWEB)

    Olson, C.C. [Sandia National Labs., Albuquerque, NM (United States); Lee, E. [Lawrence Berkeley Lab., CA (United States); Langdon, B. [Lawrence Livermore National Lab., CA (United States)

    1994-12-31

    This report contains research in the following areas related to beam transport for a common ion driver: multi-gap acceleration; neutralization with electrons; gas neutralization; self-pinched transport; HIF and LIF transport, and relevance to common ion driver; LIF and HIF reactor concepts and relevance to common ion driver; atomic physics for common ion driver; code capabilities and needed improvement.

  20. Estimating total manoeuvring time of drivers using Gamma ...

    African Journals Online (AJOL)

    The ages of drivers, service period of vehicles, and pavement conditions were also obtained by interviewing the drivers. A model of cumul-ative response times of driver-vehicle-road interaction developed indicated that TMT was contributed by the interactions of driver perception-reaction time, steering time and vehicle ...

  1. Assessing drivers' response during automated driver support system failures with non-driving tasks.

    Science.gov (United States)

    Shen, Sijun; Neyens, David M

    2017-06-01

    With the increase in automated driver support systems, drivers are shifting from operating their vehicles to supervising their automation. As a result, it is important to understand how drivers interact with these automated systems and evaluate their effect on driver responses to safety critical events. This study aimed to identify how drivers responded when experiencing a safety critical event in automated vehicles while also engaged in non-driving tasks. In total 48 participants were included in this driving simulator study with two levels of automated driving: (a) driving with no automation and (b) driving with adaptive cruise control (ACC) and lane keeping (LK) systems engaged; and also two levels of a non-driving task (a) watching a movie or (b) no non-driving task. In addition to driving performance measures, non-driving task performance and the mean glance duration for the non-driving task were compared between the two levels of automated driving. Drivers using the automated systems responded worse than those manually driving in terms of reaction time, lane departure duration, and maximum steering wheel angle to an induced lane departure event. These results also found that non-driving tasks further impaired driver responses to a safety critical event in the automated system condition. In the automated driving condition, driver responses to the safety critical events were slower, especially when engaged in a non-driving task. Traditional driver performance variables may not necessarily effectively and accurately evaluate driver responses to events when supervising autonomous vehicle systems. Thus, it is important to develop and use appropriate variables to quantify drivers' performance under these conditions. Copyright © 2017 Elsevier Ltd and National Safety Council. All rights reserved.

  2. Climate drivers of regionally synchronous fires in the inland northwest (1651-1900)

    Science.gov (United States)

    Emily K. Heyerdahl; Donald McKenzie; Lori D. Daniels; Amy E. Hessl; Jeremy S. Littell; Nathan J. Mantua

    2008-01-01

    We inferred climate drivers of regionally synchronous surface fires from 1651 to 1900 at 15 sites with existing annually accurate fire-scar chronologies from forests dominated by ponderosa pine or Douglas-fir in the inland Northwest (interior Oregon,Washington and southern British Columbia).Years with widespread fires (35 years with fire at 7 to 11 sites) had warm...

  3. Hydrochloric acid: an overlooked driver of environmental change.

    Science.gov (United States)

    Evans, Chris D; Monteith, Don T; Fowler, David; Cape, J Neil; Brayshaw, Susan

    2011-03-01

    Research on the ecosystem impacts of acidifying pollutants, and measures to control them, has focused almost exclusively on sulfur (S) and nitrogen (N) compounds. Hydrochloric acid (HCl), although emitted by coal burning, has been overlooked as a driver of ecosystem change because most of it was considered to redeposit close to emission sources rather than in remote natural ecosystems. Despite receiving little regulatory attention, measures to reduce S emissions, and changes in energy supply, have led to a 95% reduction in United Kingdom HCl emissions within 20 years. Long-term precipitation, surface water, and soil solution data suggest that the near-disappearance of HCl from deposition could account for 30-40% of chemical recovery from acidification during this time, affecting both near-source and remote areas. Because HCl is highly mobile in reducing environments, it is a more potent acidifier of wetlands than S or N, and HCl may have been the major driver of past peatland acidification. Reduced HCl loadings could therefore have affected the peatland carbon cycle, contributing to increases in dissolved organic carbon leaching to surface waters. With many regions increasingly reliant on coal for power generation, HCl should be recognized as a potentially significant constituent of resulting emissions, with distinctive ecosystem impacts.

  4. Redesign of Transjakarta Bus Driver's Cabin

    Science.gov (United States)

    Mardi Safitri, Dian; Azmi, Nora; Singh, Gurbinder; Astuti, Pudji

    2016-02-01

    Ergonomic risk at work stations with type Seated Work Control was one of the problems faced by Transjakarta bus driver. Currently “Trisakti” type bus, one type of bus that is used by Transjakarta in corridor 9, serving route Pinang Ranti - Pluit, gained many complaints from drivers. From the results of Nordic Body Map questionnaires given to 30 drivers, it was known that drivers feel pain in the neck, arms, hips, and buttocks. Allegedly this was due to the seat position and the button/panel bus has a considerable distance range (1 meter) to be achieved by drivers. In addition, preliminary results of the questionnaire using Workstation Checklist identified their complaints about uncomfortable cushion, driver's seat backrest, and the exact position of the AC is above the driver head. To reduce the risk level of ergonomics, then did research to design the cabin by using a generic approach to designing products. The risk analysis driver posture before the design was done by using Rapid Upper Limb Assessment (RULA), Rapid Entire Body Assessment (REBA), and Quick Exposure Checklist (QEC), while the calculation of the moment the body is done by using software Mannequin Pro V10.2. Furthermore, the design of generic products was done through the stages: need metric-matrix, house of quality, anthropometric data collection, classification tree concept, concept screening, scoring concept, design and manufacture of products in the form of two-dimensional. While the design after design risk analysis driver posture was done by using RULA, REBA, and calculation of moments body as well as the design visualized using software 3DMax. From the results of analysis before the draft design improvements cabin RULA obtained scores of 6, REBA 9, and the result amounted to 57.38% QEC and moment forces on the back is 247.3 LbF.inch and on the right hip is 72.9 LbF.in. While the results of the proposed improvements cabin design RULA obtained scores of 3, REBA 4, and the moment of force on

  5. [Occupational stress situation analysis of different types of train drivers].

    Science.gov (United States)

    Zhou, Wenhui; Gu, Guizhen; Wu, Hui; Yu, Shanfa

    2014-11-01

    To analyze the status of occupational stress in different types of train drivers. By using cluster sampling method, a cross-sectional study was conducted in 1 339 train drivers (including 289 passenger train drivers, 637 freight trains drivers, 339 passenger shunting train drivers, and 74 high speed rail drivers) from a Railway Bureau depot. The survey included individual factors, occupational stress factors, stress response factors and stress mitigating factors. The occupational stress factors, stress response factors and mitigating factors were measured by the revised effort-reward imbalance (ERI) model questionnaires and occupational stress measurement scale. By using the method of covariance analysized the difference of occupational stress factors of all types train drivers, the method of Stepwise regression was used to analyze the effection (R(2)) of occupational stress factors and stress mitigating factors on stress response factors. Covariance analysis as covariates in age, education level, length of service and marital status showed that the scores of ERI (1.58 ± 0.05), extrinsic effort (19.88 ± 0.44), rewards (23.43 ± 0.43), intrinsic effort (17.86 ± 0.36), physical environment (5.70 ± 0.22), social support (30.51 ± 0.88) and daily tension (10.27 ± 0.38 ) of high speed rail drivers were higher than other drivers (F values were 6.06, 11.32, 7.05, 13.25, 5.20, 9.48 and 6.14 respectively, P train drivers were higher than other drivers (F values were 4.33 and 5.50 respectively, P train drivers was high speed rail drivers (R(2) = 0.64), passenger train drivers (R(2) = 0.44), passenger shunting train drivers (R(2) = 0.39), freight trains drivers (R(2) = 0.38); job satisfaction of train drivers was high speed rail drivers (R(2) = 0.68), passenger train drivers (R(2) = 0.62), freight trains drivers (R(2) = 0.43), passenger shunting train drivers(R(2) = 0.38); to daily tension of train drivers was high speed rail drivers (R(2) = 0.54), passenger train

  6. Railway suicide: the psychological effects on drivers.

    Science.gov (United States)

    Farmer, R; Tranah, T; O'Donnell, I; Catalan, J

    1992-05-01

    People have jumped (or fallen) in front of trains on the London Underground system in increasing numbers throughout the twentieth century. During the past decade there have been about 100 such incidents each year, of which around 90 would involve the train driver witnessing his train strike the person on the track. Most are suicides or attempts at suicide. They represent major unexpected and violent events in the lives of the train drivers and it might be expected that some of them would respond by developing a post-traumatic stress reaction of the type identified by Horowitz (1976) or other adverse psychological reactions or both. The research reported in this paper was designed to characterize the range of responses of drivers to the experiences of killing or injuring members of the public during the course of their daily work. It was found that 16.3% of the drivers involved in incidents did develop post-traumatic stress disorder and that other diagnoses, e.g. depression and phobic states, were present in 39.5% of drivers when interviewed one month after the incident.

  7. Visual problems of new malaysian drivers.

    Science.gov (United States)

    Haliza, Am; Md Muziman Syah, Mms; Norliza, Mf

    2010-01-01

    The objective of this study was to determine the prevalence of poor visual acuity, colour blindness and visual field defect of new Malaysian drivers. A total of 3717 new drivers (50.2% males and 49.8% females) age 19±6 years, voluntarily participated in this study. Standard optometric apparatus such as LogMAR Charts, Ishihara plates and HandHeld Bernell Perimeter were used and standard procedures were applied. The visual examination showed 6.7% (n=250) of subjects achieved less than 0.3 LogMAR with better eye whilst 2.2% (n=83) had failed the Ishihara Test (2.1% males and 0.1% females). Most of the affected drivers were deutranopia. Only 2094 subjects had their visual field using a mobile Handheld Bernell Perimeter. 1.72% (n=36) subjects have less than 120 degrees of peripheral field of vision. The visual status among new Malaysian drivers needs to be taken seriously to ensure safe driving. Other factors such as colour vision and visual field screening have to be considered seriously when evaluating the visual performance of a driver. Good visual performance is indispensible for safe driving.

  8. Driver's Behavior Modeling Using Fuzzy Logic

    Directory of Open Access Journals (Sweden)

    Sehraneh Ghaemi

    2010-01-01

    Full Text Available In this study, we propose a hierarchical fuzzy system for human in a driver-vehicle-environment system to model takeover by different drivers. The driver's behavior is affected by the environment. The climate, road and car conditions are included in fuzzy modeling. For obtaining fuzzy rules, experts' opinions are benefited by means of questionnaires on effects of parameters such as climate, road and car conditions on driving capabilities. Also the precision, age and driving individuality are used to model the driver's behavior. Three different positions are considered for driving and decision making. A fuzzy model called Model I is presented for modeling the change of steering angle and speed control by considering time distances with existing cars in these three positions, the information about the speed and direction of car, and the steering angle of car. Also we obtained two other models based on fuzzy rules called Model II and Model III by using Sugeno fuzzy inference. Model II and Model III have less linguistic terms than Model I for the steering angle and direction of car. The results of three models are compared for a driver who drives based on driving laws.

  9. A radiation tolerant 5 Gb/s Laser Driver in 130 nm CMOS technology

    Science.gov (United States)

    Mazza, G.; Rivetti, A.; Moreira, P.; Wyllie, K.; Soos, C.; Troska, J.; Gui, P.

    2012-01-01

    The GigaBit Transceiver (GBT) project aims at the design of a radiation tolerant chip set for high speed optical data transmission. The chipset includes the GigaBit Laser Driver (GBLD), a radiation tolerant ASIC designed in a standard CMOS 130 nm technology. The GBLD is a laser driver designed to work to up to 5 Gb/s and capable to drive both Vertical Cavity Surface Emitting Lasers (VCSELs) and Edge Emitting Lasers (EELs). The GBLD can provide a modulation current up to 24 mA and a bias current up to 43 mA with the pre-emphasis function to compensate for external capacitive load.

  10. Determinants and Drivers of Infectious Disease Threat Events in Europe.

    Science.gov (United States)

    Semenza, Jan C; Lindgren, Elisabet; Balkanyi, Laszlo; Espinosa, Laura; Almqvist, My S; Penttinen, Pasi; Rocklöv, Joacim

    2016-04-01

    Infectious disease threat events (IDTEs) are increasing in frequency worldwide. We analyzed underlying drivers of 116 IDTEs detected in Europe during 2008-2013 by epidemic intelligence at the European Centre of Disease Prevention and Control. Seventeen drivers were identified and categorized into 3 groups: globalization and environment, sociodemographic, and public health systems. A combination of >2 drivers was responsible for most IDTEs. The driver category globalization and environment contributed to 61% of individual IDTEs, and the top 5 individual drivers of all IDTEs were travel and tourism, food and water quality, natural environment, global trade, and climate. Hierarchical cluster analysis of all drivers identified travel and tourism as a distinctly separate driver. Monitoring and modeling such disease drivers can help anticipate future IDTEs and strengthen control measures. More important, intervening directly on these underlying drivers can diminish the likelihood of the occurrence of an IDTE and reduce the associated human and economic costs.

  11. Linear transformer driver for pulse generation

    Science.gov (United States)

    Kim, Alexander A; Mazarakis, Michael G; Sinebryukhov, Vadim A; Volkov, Sergey N; Kondratiev, Sergey S; Alexeenko, Vitaly M; Bayol, Frederic; Demol, Gauthier; Stygar, William A

    2015-04-07

    A linear transformer driver includes at least one ferrite ring positioned to accept a load. The linear transformer driver also includes a first power delivery module that includes a first charge storage devices and a first switch. The first power delivery module sends a first energy in the form of a first pulse to the load. The linear transformer driver also includes a second power delivery module including a second charge storage device and a second switch. The second power delivery module sends a second energy in the form of a second pulse to the load. The second pulse has a frequency that is approximately three times the frequency of the first pulse. The at least one ferrite ring is positioned to force the first pulse and the second pulse to the load by temporarily isolating the first pulse and the second pulse from an electrical ground.

  12. Analysis of driver performance under reduced visibility

    Science.gov (United States)

    Kaeppler, W. D.

    1982-01-01

    Mathematical models describing vehicle dynamics as well as human behavior may be useful in evaluating driver performance and in establishing design criteria for vehicles more compatible with man. In 1977, a two level model of driver steering behavior was developed, but its parameters were identified for clear visibility conditions only. Since driver performance degrades under conditions of reduced visibility, e.g., fog, the two level model should be investigated to determine its applicability to such conditions. The data analysis of a recently performed driving simulation experiment showed that the model still performed reasonably well under fog conditions, although there was a degradation in its predictive capacity during fog. Some additional parameters affecting anticipation and lag time may improve the model's performance for reduced visibility conditions.

  13. Drivers and moderators of business decline

    Directory of Open Access Journals (Sweden)

    Marius Pretorius

    2010-12-01

    Full Text Available Purpose: Reports of business failure elicit various reactions, while research in this domain often appears to be limited by a lack of access to information about failure and by the negativity that surrounds it. Those who have experienced failure do not readily talk about it, or they disappear from the radar screen of researchers. Yet failure is preceded by decline which, when focused on strategically, can reduce eventual failures if early action is taken. The main purpose of this study is to develop a conceptual framework or typology of the drivers and moderators of business decline. Design/methodology/approach: After applying the "grounded theory" approach to the academic literature on decline and failure, a conceptual framework for the variables that drive and moderate business decline is proposed. Findings: The study proposes that decline has three core drivers, three peripheral drivers and four moderators. The core drivers identified are: resource munificence; leadership as origin; and causality (strategic versus operational origin of decline. The three peripheral drivers are: unique preconditions; continuous decisions impact; and extremes dichotomy. The study describes four moderators of the drivers: life cycle stage; stakeholder perspective; quantitative versus qualitative nature of signs and causes; and finally the age and size effects. Research limitations/implications: The proposed conceptual framework is based on literature only, although it has found support during discussions with practitioners. It is proposed to readers of this journal for scrutiny and validation. Practical implications: Strategists need to understand what drives decline in order to act timeously; practitioners who have an insight into the moderators with their impacts could make better decisions in response to decline in organisations and possibly avoid business failure. Originality/Value: Understanding business decline is still a huge theoretical challenge, which

  14. 'The best drivers in the world'

    DEFF Research Database (Denmark)

    Fynbo, Lars; Järvinen, Margaretha Maria

    2011-01-01

    The paper analyses risk behaviour as described by a group of convicted drink-drivers. Risk assessment is seen as a part of a complicated process reflecting moral values in specific socio-cultural settings and within a specific framework of time. The respondents’ retrospective accounts of their dr......The paper analyses risk behaviour as described by a group of convicted drink-drivers. Risk assessment is seen as a part of a complicated process reflecting moral values in specific socio-cultural settings and within a specific framework of time. The respondents’ retrospective accounts...

  15. Visual Problems of New Malaysian Drivers

    OpenAIRE

    Haliza, AM; Md Muziman Syah, MMS; Norliza, MF

    2010-01-01

    Purpose: The objective of this study was to determine the prevalence of poor visual acuity, colour blindness and visual field defect of new Malaysian drivers. Methods: A total of 3717 new drivers (50.2% males and 49.8% females) age 19±6 years, voluntarily participated in this study. Standard optometric apparatus such as LogMAR Charts, Ishihara plates and HandHeld Bernell Perimeter were used and standard procedures were applied. Results: The visual examination showed 6.7% (n=250) of subjects a...

  16. Enhancing digital driver models: identification of distinct postural strategies used by drivers.

    Science.gov (United States)

    Kyung, Gyouhyung; Nussbaum, Maury A; Babski-Reeves, Kari L

    2010-03-01

    Driver workspace design and evaluation is, in part, based on assumed driving postures of users and determines several ergonomic aspects of a vehicle, such as reach, visibility and postural comfort. Accurately predicting and specifying standard driving postures, hence, are necessary to improve the ergonomic quality of the driver workspace. In this study, a statistical clustering approach was employed to reduce driving posture simulation/prediction errors, assuming that drivers use several distinct postural strategies when interacting with automobiles. 2-D driving postures, described by 16 joint angles, were obtained from 38 participants with diverse demographics (age, gender) and anthropometrics (stature, body mass) and in two vehicle classes (sedans and SUVs). Based on the proximity of joint angle sets, cluster analysis yielded three predominant postural strategies in each vehicle class (i.e. 'lower limb flexed', 'upper limb flexed' and 'extended'). Mean angular differences between clusters ranged from 3.8 to 52.4 degrees for the majority of joints, supporting the practical relevance of the distinct clusters. The existence of such postural strategies should be considered when utilising digital human models (DHMs) to enhance and evaluate driver workspace design ergonomically and proactively. STATEMENT OF RELEVANCE: This study identified drivers' distinct postural strategies, based on actual drivers' behaviours. Such strategies can facilitate accurate positioning of DHMs and hence help design ergonomic driver workspaces.

  17. An application of the driver behavior questionnaire to Chinese carless young drivers.

    Science.gov (United States)

    Zhang, Qian; Jiang, Zuhua; Zheng, Dongpeng; Wang, Yifan; Man, Dong

    2013-01-01

    Carless young drivers refers to those drivers aged between 18 and 25 years who have a driver's license but seldom have opportunities to practice their driving skills because they do not have their own cars. Due to China's lower private car ownership, many young drivers turn into carless young drivers after licensure, and the safety issue associated with them has become a matter of great concern in China. Because few studies have examined the driving behaviors of these drivers, this study aims to utilize the Driver Behavior Questionnaire (DBQ) to investigate the self-reported driving behaviors of Chinese carless young drivers. A total of 523 Chinese carless young drivers (214 females, 309 males) with an average age of 21.91 years completed a questionnaire including the 27-item DBQ and demographics. The data were first randomized into 2 subsamples for factor analysis and then combined together for the following analyses. Both an exploratory factor analysis (EFA, n = 174) and a confirmatory factor analysis (CFA, n = 349) were performed to investigate the factor structure of the DBQ. Correlation analysis was conducted to examine the relationships between the demographics and the DBQ scales' variables. Multivariate linear regression and logistic regression were performed to investigate the prediction of the DBQ scales and crash involvement in the previous year. The EFA produced a 4-factor structure identified as errors, violations, attention lapses, and memory lapses, and the CFA revealed a good model fit after the removal of one item with a low factor loading and the permission of the error covariance between some items. The Chinese carless young drivers reported a comparatively low level of aberrant driving behaviors. The 3 most frequently reported behaviors were all lapses and the 3 least were all violations. Gender was the only significant predictor of the 2 lapses scales and lifetime mileage was the only significant predictor of the violations scale. Only the

  18. TMACS Test Procedure TP009: Acromag Driver

    International Nuclear Information System (INIS)

    Washburn, S.J.

    1994-01-01

    The TMACS Software Project Test Procedures translate the project's acceptance criteria into test steps. Software releases are certified when the affected Test Procedures are successfully performed and the customers authorize installation of these changes. This Test Procedure tests the TMACS Acromag Software Driver (Bridge Code)

  19. Driver Performance Model: 1. Conceptual Framework

    National Research Council Canada - National Science Library

    Heimerl, Joseph

    2001-01-01

    ...'. At the present time, no such comprehensive model exists. This report discusses a conceptual framework designed to encompass the relationships, conditions, and constraints related to direct, indirect, and remote modes of driving and thus provides a guide or 'road map' for the construction and creation of a comprehensive driver performance model.

  20. Clear roads' safety effect on elderly drivers.

    Science.gov (United States)

    2011-10-01

    Driving on roads that are covered with ice or snow is hazardous for all drivers, but there may be : disproportionally high risks for certain age groups on certain road types and different winter : maintenance practices may also have a greater influen...

  1. Drivers of Diversification in Individual Life Courses

    DEFF Research Database (Denmark)

    Hernandez-Pacheco, Raisa; Steiner, Ulrich K

    2017-01-01

    Heterogeneity in life courses among individuals of a population influences the speed of adaptive evolutionary processes, but it is less clear how biotic and abiotic environmental fluctuations influence such heterogeneity. We investigate principal drivers of variability in sequence of stages durin...

  2. ITER driver blanket, European Community design

    International Nuclear Information System (INIS)

    Simbolotti, G.; Zampaglione, V.; Ferrari, M.; Gallina, M.; Mazzone, G.; Nardi, C.; Petrizzi, L.; Rado, V.; Violante, V.; Daenner, W.; Lorenzetto, P.; Gierszewski, P.; Grattarola, M.; Rosatelli, F.; Secolo, F.; Zacchia, F.; Caira, M.; Sorabella, L.

    1993-01-01

    Depending on the final decision on the operation time of ITER (International Thermonuclear Experimental Reactor), the Driver Blanket might become a basic component of the machine with the main function of producing a significant fraction (close to 0.8) of the tritium required for the ITER operation, the remaining fraction being available from external supplies. The Driver Blanket is not required to provide reactor relevant performance in terms of tritium self-sufficiency. However, reactor relevant reliability and safety are mandatory requirements for this component in order not to significantly afftect the overall plant availability and to allow the ITER experimental program to be safely and successfully carried out. With the framework of the ITER Conceptual Design Activities (CDA, 1988-1990), a conceptual design of the ITER Driver Blanket has been carried out by ENEA Fusion Dept., in collaboration with ANSALDO S.p.A. and SRS S.r.l., and in close consultation with the NET Team and CFFTP (Canadian Fusion Fuels Technology Project). Such a design has been selected as EC (European Community) reference design for the ITER Driver Blanket. The status of the design at the end of CDA is reported in the present paper. (orig.)

  3. CARess, a gentle touch informs the driver

    DEFF Research Database (Denmark)

    Trento, Stefano; Götzen, Amalia De; Serafin, Stefania

    2014-01-01

    A prototype of Human Machine Interface (HMI) used to de- liver information to the driver in cars is described in this paper. The de- livery of information is based on the Informative Interruptive Cue (IIC) approach. The interface is a matrix of 4 x 3 vibrating motors, controlled through a real-ti...

  4. Innovation drivers and barriers in food processing

    NARCIS (Netherlands)

    Fortuin, F.T.J.M.; Omta, S.W.F.

    2009-01-01

    Purpose - The food processing industry, confronted with increased global competition and more stringent customer demands, is pressurized to improve the pace and quality of its innovation processes. This paper aims to find out what factors constitute the main drivers and barriers to innovation and to

  5. Driver behavior at urban roads in China

    NARCIS (Netherlands)

    Li, J.; van Zuylen, H.J.; van der Horst, E.

    2014-01-01

    Driver behavior in China shows remarkable differences from that in western countries. In this study, six focus groups were organized to investigate Chinese drivers’ attitudes, expectations, intended actions, their preferences, and habits in different situations in urban areas. The outcomes show that

  6. Entrepreneurial aspirations, motivations, and their drivers

    NARCIS (Netherlands)

    S.J.A. Hessels (Jolanda); A.M. van Gelderen (Marco); A.R. Thurik (Roy)

    2008-01-01

    textabstractSeveral drivers of entrepreneurial aspirations and entrepreneurial motivations are investigated using country-level data from the Global Entrepreneurship Monitor (GEM) for the years 2005 and 2006. We estimate a two-equation model explaining aspirations using motivations and socioeconomic

  7. Entrepreneurial aspirations, motivations, and their drivers

    NARCIS (Netherlands)

    Hessels, J.; van Gelderen, M.W.; Thurik, A.R.

    2008-01-01

    Several drivers of entrepreneurial aspirations and entrepreneurial motivations are investigated using country-level data from the Global Entrepreneurship Monitor (GEM) for the years 2005 and 2006. We estimate a two-equation model explaining aspirations using motivations and socioeconomic variables,

  8. Federally Mandated Testing of Bus Drivers.

    Science.gov (United States)

    Wright, Jim

    1993-01-01

    Proposed rules by the U.S. Department of Transportation (DOT) for drug and alcohol testing of school bus drivers are expected to be implemented by early 1994. DOT regulations are very specific. School districts need to decide whether to establish their own program or contract with a full-service drug-testing firm. Explains the seven major elements…

  9. Math on the Job. Taxi Driver.

    Science.gov (United States)

    Ohio State Univ., Columbus. National Center for Research in Vocational Education.

    This booklet is intended to help mainstreamed mentally retarded, emotionally disturbed, or learning disabled high school students acquire a basic understanding of the responsibilities and working conditions of taxi drivers and to practice basic math skills necessary in the occupation. The first section provides a brief introduction to the…

  10. Advanced Competencies for School Bus Drivers.

    Science.gov (United States)

    Illinois State Board of Education, Springfield.

    Four units are provided for formal classroom instruction in advanced competencies for school bus drivers in Illinois. Units cover passenger control, accidents and emergencies, detecting hazards, and first aid. Each unit contains some or all of the following components: table of contents; a list of objectives; informative material, including an…

  11. Driver Education for Motorcycle Operation. Final Report.

    Science.gov (United States)

    Council, Forrest M.; And Others

    A three-year pilot project was conducted to evaluate the feasibility of implementing a statewide off-road motorcycle training program for beginning drivers in North Carolina. The first year of the program involved approximately 422 students from five locations, the second year involved seven sites across the State. The three basic criteria for the…

  12. 29 CFR 782.4 - Drivers' helpers.

    Science.gov (United States)

    2010-07-01

    ... interstate or foreign commerce, because, in the case of an accident or other emergency and in other respects... accidents occur, they help the driver in obtaining aid and protect the vehicle from oncoming traffic. (c) In... commerce within the meaning of the Motor Carrier Act. (Ispass v. Pyramid Motor Freight Corp., 152 F. (2d...

  13. Reduced Component Count RGB LED Driver

    NARCIS (Netherlands)

    De Pedro, I.; Ackermann, B.

    2008-01-01

    The goal of this master thesis is to develop new drive and contrololutions, for creating white light from mixing the light of different-color LEDs, aiming at a reduced component count resulting in less space required by the electronics and lower cost. It evaluates the LED driver concept proposed in

  14. Deregulation and Macroeconomic Drivers Of Foreign Direct ...

    African Journals Online (AJOL)

    Deregulation and Macroeconomic Drivers Of Foreign Direct Investment In Nigerian Agriculture (1970 -2009): An Econometric Analysis. ... The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader). If you would like more ...

  15. Invoking Device Driver from .NET Managed Code

    Directory of Open Access Journals (Sweden)

    Xie Peng

    2016-01-01

    Full Text Available It’s a real problem to visit a low-level device driver from a high-level application based on the .NET platform managed code in software developing practice .This paper concerns how to solve it by a runtime interoperation services provided by Microsoft .NET Common Language Runtime (CLR .A real world example is given in the end.

  16. Licensing procedures and older drivers : traffic tech.

    Science.gov (United States)

    2013-09-01

    People 65 and older are the fastest growing demographic : group in the United States. This is cause for concern given : that the youngest and oldest drivers have the highest crash : rates per unit of distance traveled, with rates increasing for : old...

  17. Driver electronic device use in 2008

    Science.gov (United States)

    2009-09-01

    The 2008 hand-held cell phone use rate translates into 812,000 vehicles being driven by someone using a hand-held cell phone at any given daylight moment.1 It also translates into an estimated 11 percent of the vehicles whose drivers were using some ...

  18. Improving safety of teenage and young adult drivers in Kansas.

    Science.gov (United States)

    2013-12-01

    Statistics show that young drivers have higher motor vehicle crash rates compared to other age groups. This study investigated : characteristics, contributory causes, and factors which increase injury severity of young driver crashes in Kansas by com...

  19. A UNIX device driver for a Translink II Transputer board

    International Nuclear Information System (INIS)

    Wiley, J.C.

    1991-01-01

    A UNIX device driver for a TransLink II Transputer board is described. A complete listing of the code is presented. The device driver allows a transputer array to be used with the A/UX operating system

  20. Development of a statistical method for predicting human driver decisions.

    Science.gov (United States)

    2015-09-01

    As autonomous vehicles enter the fleet, there will be a long period when these vehicles will have to interact with : human drivers. One of the challenges for autonomous vehicles is that human drivers do not communicate their : decisions well. However...

  1. 77 FR 76167 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-12-26

    ... applications. The notices of applications stated in detail the qualifications, experience, and medical... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... annual medical certification to the employer for retention in the driver's qualification file and retains...

  2. 77 FR 56262 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-09-12

    ... of applications stated in detail the qualifications, experience, and medical condition of each... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... the employer for retention in the driver's qualification file and retains a copy of the certification...

  3. 76 FR 9861 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-02-22

    ... applications. The notices of applications stated in detail the qualifications, experience, and medical...; FMCSA- 25246] Qualification of Drivers; Exemption Applications; Vision AGENCY: Federal Motor Carrier... annual medical certification to the employer for retention in the driver's qualification file and retains...

  4. 77 FR 74734 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-12-17

    .... The notices of applications stated in detail the qualifications, experience, and medical condition of... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... annual medical certification to the employer for retention in the driver's qualification file and retains...

  5. Driver ASICs for Advanced Deformable Mirrors, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The overall goal of the SBIR program is to develop a new Application Specified Integrated Circuit (ASIC) driver to be used in driver electronics of a deformable...

  6. The effect of passengers on teen driver behavior : traffic tech.

    Science.gov (United States)

    2012-04-01

    A number of studies have shown that passengers substantially : increase the risk of crashes for young, novice drivers. : This increased risk may result from distractions that young : passengers create for drivers. Alternatively, the presence : of pas...

  7. The Effect of Passengers on Teen Driver Behavior

    Science.gov (United States)

    2012-04-01

    A number of studies have shown that passengers substantially increase the risk of crashes for young, novice drivers. This increased risk may result from distractions that young passengers create for drivers. Alternatively, the presence of passengers ...

  8. Methodology to evaluate teen driver training programs : [brief].

    Science.gov (United States)

    2014-03-01

    In the United States, teenage drivers are more at risk of being involved in crashes than : any other age group. Statistics reveal a clear need for improving teenagers driving : skills, judgment and behavior. Driver education programs are a crucial...

  9. 78 FR 78479 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-12-26

    ...-0192] Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier... insulin- treated diabetes mellitus (ITDM) operating commercial motor vehicles (CMVs) in interstate... individual assessment of drivers with diabetes mellitus, and be consistent with the criteria described in...

  10. 77 FR 70530 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2012-11-26

    ...-0348] Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of applications for exemption from the diabetes... revision must provide for individual assessment of drivers with diabetes mellitus, and be consistent with...

  11. 78 FR 12809 - Qualification of Drivers; Application for Exemptions; Hearing

    Science.gov (United States)

    2013-02-25

    ... interstate commerce, if he is granted an exemption. Zachary Rietz Mr. Reitz holds a driver's license from the... commerce, if granted an exemption. Bryon Smith Mr. Smith holds a driver's license from the state of...

  12. Driver education practices in selected states : traffic tech.

    Science.gov (United States)

    2011-07-01

    Teen drivers have the highest crash rate per mile driven of any : age group (Williams, Ferguson, & Wells, 2005). Immaturity and : inexperience are two explanations for why novice teen drivers : have such a high crash risk (Arnett, 1992; Mayhew, Simps...

  13. Issuance of driver licenses and identification cards to prisoners.

    Science.gov (United States)

    2010-06-01

    In 2009, the Oregon Legislature passed House Bill 2489, requiring the Oregon Driver and Motor Vehicle (DMV) Services Division and the Department of Corrections (DOC) to enter into agreements and adopt rules to assist offenders in obtaining a driver l...

  14. 2007 motor vehicle occupant safety survey : driver education and graduated driver licensing

    Science.gov (United States)

    2008-12-01

    This Research Note summarizes selected results from the 2007 MVOSS. It focuses primarily on information collected regarding driver education and GDL. This was a new module introduced in 2007. The data are weighted to yield national estimates.

  15. Odds of fault and factors for out-of-state drivers in crashes in four states of the USA.

    Science.gov (United States)

    Harootunian, Kristine; Lee, Brian H Y; Aultman-Hall, Lisa

    2014-11-01

    Drivers outside their country of residence are at a safety disadvantage when compared to native counterparts. This research aimed to (1) investigate if out-of-state drivers in the United States experienced the same vulnerabilities as foreign drivers, and (2) examine the relations of out-of-state crashes to various human and environmental factors. Crash data from Florida, Maine, Minnesota, and Nevada was analyzed to model fault using logistic regressions. Univariate regressions showed that out-of-state drivers had increased odds of fault, ranging from 17% to 92%, for a single-vehicle crash compared to in-state drivers in all states except Florida, where there was no difference between groups. Odds were elevated for out-of-state drivers in two-vehicle crashes by 3% to 19% in all states except Florida and Minnesota, where, again, there was no difference between groups. Human and environmental factors such as age, sex, driving conditions, and seasons were examined with multivariate regressions for in- and out-of-state groups separately, and their odds ratios were compared. For single-vehicle crashes age, sex, road grade, surface condition, light conditions, and day of week were factors that increased at least one of the two groups' odds of fault in all states. Sex, surface condition, and light conditions increased the odds of fault for at least one of the groups in two-vehicle crashes in all four states. Factors that consistently increased odds of fault for both single- and two-vehicle crashes were males, non-vehicle owners, curves, and inclement weather. Although there were several factors in each state that increased odds of fault for out-of-state drivers, no factors consistently increased odds of fault for out-of-state drivers across all four states. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. Cardiovascular Risk Factors of Taxi Drivers.

    Science.gov (United States)

    Elshatarat, Rami Azmi; Burgel, Barbara J

    2016-06-01

    In the United States (U.S.), cardiovascular disease (CVD) is a major leading cause of death. Despite the high mortality rate related to CVD, little is known about CVD risk factors among urban taxi drivers in the U.S. A cross-sectional design was used to identify the predictors of high cardiovascular risk factors among taxi drivers. Convenience sampling method was used to recruit 130 taxi drivers. A structured questionnaire was used to obtain the data. The sample was male (94 %), age mean (45 ± 10.75) years, married (54 %), born outside of the USA (55 %), had some college or below (61.5 %), night drivers (50.8 %), and driving on average 9.7 years and 41 h/week. About 79 % of them were eligible for CVD prevention, and 35.4 % had high CVD risk factors (4-9 risk factors). A CVD high-risk profile had a significant relationship with the subjects who were ≥55 years old; had hypertension, diabetes, or hyperlipidemia; were drinking alcohol ≥2 times/week; and had insufficient physical activity. Subjects who worked as a taxi driver for more than 10 years (OR 4.37; 95 % CI 1.82, 10.50) and had mental exertion from cab driving >5 out of 10 (OR 2.63; 95 % CI 1.05, 6.57) were more likely to have a CVD high-risk profile. As a conclusion, system-level or worksite interventions include offering healthy food at taxi dispatching locations, creating a work culture of frequent walking breaks, and interventions focusing on smoking, physical activity, and weight management. Improving health insurance coverage for this group of workers is recommended.

  17. An evidence-based review: distracted driver.

    Science.gov (United States)

    Llerena, Luis E; Aronow, Kathy V; Macleod, Jana; Bard, Michael; Salzman, Steven; Greene, Wendy; Haider, Adil; Schupper, Alex

    2015-01-01

    Cell phone use and texting are prevalent within society and have thus pervaded the driving population. This technology is a growing concern within the confines of distracted driving, as all diversions from attention to the road have been shown to increase the risk of crashes. Adolescent, inexperienced drivers, who have the greatest prevalence of texting while driving, are at a particularly higher risk of crashes because of distraction. Members of the Injury Control Violence Prevention Committee of the Eastern Association for the Surgery of Trauma performed a PubMed search of articles related to distracted driving and cell phone use as a distractor of driving between 2000 and 2013. A total of 19 articles were found to merit inclusion as evidence in the evidence-based review. These articles provided evidence regarding the relationship between distracted driving and crashes, cell phone use contributing to automobile accidents, and/or the relationship between driver experience and automobile accidents. (Adjust methods/results sections to the number of articles that correctly corresponds to the number of references, as well as the methodology for reference inclusion.) Based on the evidence reviewed, we can recommend the following. All drivers should minimize all in-vehicle distractions while on the road. All drivers should not text or use any touch messaging system (including the use of social media sites such as Facebook and Twitter) while driving. Younger, inexperienced drivers should especially not use cell phones, texting, or any touch messaging system while driving because they pose an increased risk for death and injury caused by distractions while driving.

  18. Advanced driver assistance systems for teen drivers: Teen and parent impressions, perceived need, and intervention preferences.

    Science.gov (United States)

    Weiss, Eve; Fisher Thiel, Megan; Sultana, Nahida; Hannan, Chloe; Seacrist, Thomas

    2018-02-28

    From the advent of airbags to electronic stability control, technological advances introduced into automobile design have significantly reduced injury and death from motor vehicle crashes. These advances are especially pertinent among teen drivers, a population whose leading cause of death is motor vehicle crashes. Recently developed advanced driver assistance systems (ADAS) have the potential to compensate for skill deficits and reduce overall crash risk. Yet, ADAS is only effective if drivers are willing to use it. Limited research has been conducted on the suitability of ADAS for teen drivers. The goal of this study is to identify teen drivers' perceived need for ADAS, receptiveness to in-vehicle technology, and intervention preferences. The long-term goal is to understand public perceptions and barriers to ADAS use and to help determine how these systems must evolve to meet the needs of the riskiest driving populations. Three focus groups (N = 24) were conducted with licensed teen drivers aged 16-19 years and 2 focus groups with parents of teen drivers (N = 12). Discussion topics included views on how ADAS might influence driving skills and behaviors; trust in technology; and data privacy. Discussions were transcribed; the team used conventional content analysis and open coding methods to identify 12 coding domains and code transcripts with NVivo 10. Interrater reliability testing showed moderate to high kappa scores. Overall, participants recognized potential benefits of ADAS, including improved safety and crash reduction. Teens suggested that ADAS is still developing and therefore has potential to malfunction. Many teens reported a greater trust in their own driving ability over vehicle technology. They expressed that novice drivers should learn to drive on non-ADAS-equipped cars and that ADAS should be considered a supplemental aid. Many teens felt that overreliance on ADAS may increase distracted driving or risky behaviors among teens. Parents also

  19. Inertial confinement fusion driver enhancements: Final focusing systems and compact heavy-ion driver designs

    International Nuclear Information System (INIS)

    Bieri, R.L.

    1991-01-01

    Required elements of an inertial confinement fusion power plant are modeled and discussed. A detailed analysis of two critical elements of candidate drivers is done, and new component designs are proposed to increase the credibility and feasibility of each driver system. An analysis of neutron damage to the final elements of a laser focusing system is presented, and multilayer -- dielectric mirrors are shown to have damage lifetimes which axe too short to be useful in a commercial power plant. A new final-focusing system using grazing incidence metal mirrors to protect sensitive laser optics is designed and shown to be effective in extending the lifetime of the final focusing system. The reflectivities and damage limits of grazing incidence metal mirrors are examined in detail, and the required mirror sizes are shown to be compatible with the beam sizes and illumination geometries currently envisioned for laser drivers. A detailed design and analysis is also done for compact arrays of superconducting magnetic quadrupoles, which are needed in a multi-beam heavy-ion driver. The new array model is developed in more detail than some previous conceptual designs and models arrays which are more compact than arrays scaled from existing single -- quadrupole designs. The improved integrated model for compact arrays is used to compare the effects of various quadrupole array design choices on the size and cost of a heavy-ion driver. Array design choices which significantly affect the cost of a heavy-ion driver include the choice of superconducting material and the thickness of the collar used to support the winding stresses. The effect of these array design choices on driver size and cost is examined and the array model is used to estimate driver cost savings and performance improvements attainable with aggressive quadrupole array designs with high-performance superconductors

  20. Child passengers and driver culpability in fatal crashes by driver gender

    OpenAIRE

    Maasalo, Ida; Lehtonen, Esko; Pekkanen, Jami; Summala, Heikki

    2016-01-01

    AbstractObjective: Studies based on accident statistics generally suggest that the presence of a passenger reduces adult drivers' accident risk. However, passengers have been reported to be a source of distraction in a remarkable portion of distraction related crashes. Although the effect of passengers on driving performance has been studied extensively, few studies have focused on how a child passenger affects the driver. A child in a car is a potential distractor for parents, especially for...

  1. Influences of Vehicle Size and Mass and Selected Driver Factors on Odds of Driver Fatality

    OpenAIRE

    Padmanaban, Jeya

    2003-01-01

    Research was undertaken to determine vehicle size parameters influencing driver fatality odds, independent of mass, in two-vehicle collisions. Forty vehicle parameters were evaluated for 1,500 vehicle groupings. Logistic regression analyses show driver factors (belt use, age, drinking) collectively contribute more to fatality odds than vehicle factors, and that mass is the most important vehicular parameter influencing fatality odds for all crash configurations. In car crashes, other vehicle ...

  2. Monitoring the driver's activity using 3D information

    OpenAIRE

    Peláez Coronado, Gustavo Adolfo

    2016-01-01

    Driver supervision is crucial in safety systems for the driver. It is important to monitor the driver to understand his necessities, patterns of movements and behaviour under determined circumstances. The availability of an accurate tool to supervise the driver’s behaviour allows multiple objectives to be achieved such as the detection of drowsiness (analysing the head movements and blinking pattern) and distraction (estimating where the driver is looking by studying the head and eyes positio...

  3. Research on Taxi Driver Strategy Game Evolution with Carpooling Detour

    OpenAIRE

    Zhang, Wei; He, Ruichun; Ma, Changxi; Gao, Mingxia

    2018-01-01

    For the problem of taxi carpooling detour, this paper studies driver strategy choice with carpooling detour. The model of taxi driver strategy evolution with carpooling detour is built based on prospect theory and evolution game theory. Driver stable strategies are analyzed under the conditions of complaint mechanism and absence of mechanism, respectively. The results show that passenger’s complaint mechanism can effectively decrease the phenomenon of driver refusing passengers with carpoolin...

  4. DriverFinder: A Gene Length-Based Network Method to Identify Cancer Driver Genes

    Directory of Open Access Journals (Sweden)

    Pi-Jing Wei

    2017-01-01

    Full Text Available Integration of multi-omics data of cancer can help people to explore cancers comprehensively. However, with a large volume of different omics and functional data being generated, there is a major challenge to distinguish functional driver genes from a sea of inconsequential passenger genes that accrue stochastically but do not contribute to cancer development. In this paper, we present a gene length-based network method, named DriverFinder, to identify driver genes by integrating somatic mutations, copy number variations, gene-gene interaction network, tumor expression, and normal expression data. To illustrate the performance of DriverFinder, it is applied to four cancer types from The Cancer Genome Atlas including breast cancer, head and neck squamous cell carcinoma, thyroid carcinoma, and kidney renal clear cell carcinoma. Compared with some conventional methods, the results demonstrate that the proposed method is effective. Moreover, it can decrease the influence of gene length in identifying driver genes and identify some rare mutated driver genes.

  5. Schoolbus driver performance can be improved with driver training, safety incentivisation, and vehicle roadworthy modifications

    Directory of Open Access Journals (Sweden)

    A van Niekerk

    2017-03-01

    Full Text Available In South Africa (SA, the school transport industry provides millions of children with a means of travelling to and from school. The industry has, however, been reported to be plagued by widespread safety concerns. The consequent road traffic incidents have often been attributed to driver factors, including driving in excess of legal speeds or at inappropriate speeds; driving while under the influence of alcohol, while sleepy or fatigued; or driving without using protective equipment for vehicle occupants. There are currently very few SA interventions that specifically target this important industry role-player. The Safe Travel to School Programme was recently implemented by a national child safety agency, with a focus on driver road safety awareness, defensive driver training, eye- testing, vehicle roadworthy inspections with selected upgrades, incentives for safe performance, and implementation of a vehicle telematics tracking system with regular, individual driving behaviour information updates. This quasi-experimental study offers an evaluation of the initial impact on safety performance of this telematics-based driver and vehicle safety intervention in terms of speeding, acceleration, braking, cornering, and time-of-day driving, and compares the school transport driver performance with that of general motorists. Despite concerns that some school transport vehicles are used for multiple purposes outside of school transport duties, at night, and for longer distances, overall these vehicles recorded lower percentages of speeding, lower harsh braking, and lower average harsh cornering and acceleration than general drivers.

  6. 75 FR 32983 - Commercial Driver's License (CDL) Standards: Exemption

    Science.gov (United States)

    2010-06-10

    ...-28480] Commercial Driver's License (CDL) Standards: Exemption AGENCY: Federal Motor Carrier Safety... commercial driver's license (CDL) as required by current regulations. FMCSA reviewed NAAA's application for... demonstrate alternatives its members would employ to ensure that their commercial motor vehicle (CMV) drivers...

  7. Non-planar driver's side rearview mirrors: A survey of mirror types and european driver experience and a driver behavior study on the influence of experience and driver age on gap acceptance and vehicle detection (final report)

    NARCIS (Netherlands)

    Vos, A.P. de

    2000-01-01

    Some European drivers have been using different types of convex, driver-side rear-view mirrors which provide a wider field-of-view than flat mirrors, but produce a minified image. With a minified image, some drivers may have difficulty judging distances and approach speeds. To assess the potential

  8. The importance of heavy vehicle driver education in South Africa

    CSIR Research Space (South Africa)

    Magazi, L

    2015-07-01

    Full Text Available and the age and experience of the drivers considered before a Professional Drivers Permit (PrDP) license issued to the driver. Formal institutions such as Further Education and Training (FET) colleges needs to, in future play a bigger role in the issuing...

  9. Prevalence of Psychoactive Drug Use by Taxi Drivers in Nigeria ...

    African Journals Online (AJOL)

    Aim: To ascertain the prevalence and nature of psychoactive drug use amongst taxi drivers in Nigeria. Materials and Method: A total of 192 taxi drivers in Enugu, South East Nigeria was studied using a questionnaire. Information obtained from the questionnaire included socio-demographic characteristics of the drivers, ...

  10. 18- to 24-year-olds : young drivers.

    NARCIS (Netherlands)

    2016-01-01

    The fatality rate (fatalities per distance travelled) of young drivers (18- to 24-year-olds) is more than five times higher than that of drivers between the ages of 30 and 59 years. The fatality rate of young males is even as much as ten times higher. The high risk of young drivers is due to both

  11. Mandatory Driver Training and Road Safety: The Quebec Experience.

    Science.gov (United States)

    Potvin, Louise; And Others

    1988-01-01

    1983 legislation making driver training courses mandatory for any person in Quebec seeking a first driver's license had no effect on the risk of accident or the mortality/morbidity rate for newly licensed drivers over 18. However, since 1983 more women under 18 are becoming licensed, and their risks may be increased. (Author/BJV)

  12. Driver's anger state identification by using facial expression in ...

    African Journals Online (AJOL)

    Preventive safety system of vehicle is highlighted to reduce the number of traffic accidents. Driver's state adaptive driving safety system may be one of candidates of the safety system. Identifying driver's psychosomatic states is indispensable to establish those safety systems. Anger of driver state is often seen in traffic ...

  13. Driver medical review practices across the United States : traffic tech.

    Science.gov (United States)

    2017-04-01

    There were 38.4 million licensed older drivers in 2014a 31% : increase from 10 years earlier (2005). Furthermore, older drivers as : a percentage of all licensed drivers increased from 15% in 2005 to : 18% in 2014 (National Center for Statistics a...

  14. Different drivers create spatial vegetation cover and vertical structure ...

    African Journals Online (AJOL)

    Important drivers of woody cover in African savannas are rainfall, soil and nutrients, and disturbance factors, such as fire and herbivory. However, very little is known about how these drivers influence woody cover at specific height classes. The main aim of this study was to identify which of these drivers are the best ...

  15. Pattern of Eye Diseases among Commercial Intercity Vehicle Drivers ...

    African Journals Online (AJOL)

    Objective: To determine the pattern of eye diseases among commercial intercity vehicle drivers (CIVDs) in Ilorin, Nigeria. Design: A cross-sectional descriptive study. Methodology: Out of the estimated 450 drivers operating in the five major motor parks for CIVDs in Ilorin, 399 consecutive drivers participated in the study.

  16. High frequency MOSFET gate drivers technologies and applications

    CERN Document Server

    Zhang, Zhiliang

    2017-01-01

    This book describes high frequency power MOSFET gate driver technologies, including gate drivers for GaN HEMTs, which have great potential in the next generation of switching power converters. Gate drivers serve as a critical role between control and power devices.

  17. Licensing and Other Controls of the Drinking Driver.

    Science.gov (United States)

    Waller, Patricia F.

    Driver licensing, the only state program with the opportunity for routine personal contact with every driver, has unmatched potential for both general and specific countermeasures to the problem of drunk driving. General countermeasures apply to large groups of drivers prior to the occurrence of any infraction. They may be considered basically…

  18. Traffic safety issues in North Dakota : phase II : driver knowledge, attitude, behavior and beliefs : focus group : young male drivers

    Science.gov (United States)

    2008-10-01

    Traffic safety is a widespread social concern. Tackling the problem requires understanding the people : who are driving. This includes information about driver behavior, but also about perceptions these drivers : hold regarding their driving. North D...

  19. A COOPERATIVE ASSISTANCE SYSTEM BETWEEN VEHICLES FOR ELDERLY DRIVERS

    Directory of Open Access Journals (Sweden)

    Naohisa HASHIMOTO

    2009-01-01

    Full Text Available This paper proposes a new concept of elderly driver assistance systems, which performs the assistance by cooperative driving between two vehicles, and describes some experiments with elderly drivers. The assistance consists of one vehicle driven by an elderly driver called a guest vehicle and the other driven by a assisting driver called a host vehicle, and the host vehicle assists or escorts the guest vehicle through the inter-vehicle communications. The functions of the systems installed on a single-seat electric vehicle are highly evaluated by subjects of elderly drivers in virtual streets on a test track.

  20. The driver landscape of sporadic chordoma.

    Science.gov (United States)

    Tarpey, Patrick S; Behjati, Sam; Young, Matthew D; Martincorena, Inigo; Alexandrov, Ludmil B; Farndon, Sarah J; Guzzo, Charlotte; Hardy, Claire; Latimer, Calli; Butler, Adam P; Teague, Jon W; Shlien, Adam; Futreal, P Andrew; Shah, Sohrab; Bashashati, Ali; Jamshidi, Farzad; Nielsen, Torsten O; Huntsman, David; Baumhoer, Daniel; Brandner, Sebastian; Wunder, Jay; Dickson, Brendan; Cogswell, Patricia; Sommer, Josh; Phillips, Joanna J; Amary, M Fernanda; Tirabosco, Roberto; Pillay, Nischalan; Yip, Stephen; Stratton, Michael R; Flanagan, Adrienne M; Campbell, Peter J

    2017-10-12

    Chordoma is a malignant, often incurable bone tumour showing notochordal differentiation. Here, we defined the somatic driver landscape of 104 cases of sporadic chordoma. We reveal somatic duplications of the notochordal transcription factor brachyury (T) in up to 27% of cases. These variants recapitulate the rearrangement architecture of the pathogenic germline duplications of T that underlie familial chordoma. In addition, we find potentially clinically actionable PI3K signalling mutations in 16% of cases. Intriguingly, one of the most frequently altered genes, mutated exclusively by inactivating mutation, was LYST (10%), which may represent a novel cancer gene in chordoma.Chordoma is a rare often incurable malignant bone tumour. Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations in LYST, a potential novel cancer gene in chordoma.

  1. Identifying driver mutations in sequenced cancer genomes

    DEFF Research Database (Denmark)

    Raphael, Benjamin J; Dobson, Jason R; Oesper, Layla

    2014-01-01

    High-throughput DNA sequencing is revolutionizing the study of cancer and enabling the measurement of the somatic mutations that drive cancer development. However, the resulting sequencing datasets are large and complex, obscuring the clinically important mutations in a background of errors, noise......, and random mutations. Here, we review computational approaches to identify somatic mutations in cancer genome sequences and to distinguish the driver mutations that are responsible for cancer from random, passenger mutations. First, we describe approaches to detect somatic mutations from high-throughput DNA...... sequencing data, particularly for tumor samples that comprise heterogeneous populations of cells. Next, we review computational approaches that aim to predict driver mutations according to their frequency of occurrence in a cohort of samples, or according to their predicted functional impact on protein...

  2. Data fusion for driver behaviour analysis.

    Science.gov (United States)

    Carmona, Juan; García, Fernando; Martín, David; Escalera, Arturo de la; Armingol, José María

    2015-10-14

    A driver behaviour analysis tool is presented. The proposal offers a novel contribution based on low-cost hardware and advanced software capabilities based on data fusion. The device takes advantage of the information provided by the in-vehicle sensors using Controller Area Network Bus (CAN-BUS), an Inertial Measurement Unit (IMU) and a GPS. By fusing this information, the system can infer the behaviour of the driver, providing aggressive behaviour detection. By means of accurate GPS-based localization, the system is able to add context information, such as digital map information, speed limits, etc. Several parameters and signals are taken into account, both in the temporal and frequency domains, to provide real time behaviour detection. The system was tested in urban, interurban and highways scenarios.

  3. Drivers of Changes in Product Development Rules

    DEFF Research Database (Denmark)

    Christiansen, John K.; Varnes, Claus J.

    2015-01-01

    the relationship between the uses of structured rule-based approaches to manage product development, but little is known about what makes these rules change. This is the first study to uncover the multitude of drivers that stimulate change in product development rules and to suggest sets of moderators......Purpose: - The purpose of this research is to investigate the drivers that induce companies to change their rules for managing product development. Most companies use a form of rule-based management approach, but surprisingly little is known about what makes companies change these rules...... 10 years based on three rounds of interviews with 40 managers. Findings: - Previous research has assumed that the dynamics of product development rules are based on internal learning processes, and that increasingly competent management will stimulate the implementation of newer and more complex rule...

  4. Electromagnetic propulsion alternatives. [in mass drivers

    Science.gov (United States)

    Kolm, H.; Fine, K.; Mongeau, P.; Williams, F.

    1979-01-01

    Mass drivers can serve to propel massive objects by expelling any available material as reaction mass, however, mass driver engines have several limitations such as relatively large payload size and dynamic stability problems. A number of alternative acceleration mechanisms exist which offer advantages for certain applications, such as higher acceleration at a sacrifice in efficiency, smaller possible size and decreased complexity at a sacrifice in service life, etc. The alternative concepts include several variants of the railgun, a family of superconducting slingshot oscillators, a momentum transformer, an impulse induction motor, and a family of hybrid synchronous accelerators. A potential application of considerable interest is the earth-based launching of space cargo or nuclear waste by using off-peak generating capacity to accelerate one ton cargo cylinders at intervals of several minutes.

  5. Driver steering model for closed-loop steering function analysis

    Science.gov (United States)

    Bolia, Pratiksh; Weiskircher, Thomas; Müller, Steffen

    2014-05-01

    In this paper, a two level preview driver steering control model for the use in numerical vehicle dynamics simulation is introduced. The proposed model is composed of cascaded control loops: The outer loop is the path following layer based on potential field framework. The inner loop tries to capture the driver's physical behaviour. The proposed driver model allows easy implementation of different driving situations to simulate a wide range of different driver types, moods and vehicle types. The expediency of the proposed driver model is shown with the help of developed driver steering assist (DSA) function integrated with a conventional series production (Electric Power steering System with rack assist servo unit) system. With the help of the DSA assist function, the driver is prevented from over saturating the front tyre forces and loss of stability and controllability during cornering. The simulation results show different driver reactions caused by the change in the parameters or properties of the proposed driver model if the DSA assist function is activated. Thus, the proposed driver model is useful for the advanced driver steering and vehicle stability assist function evaluation in the early stage of vehicle dynamics handling and stability evaluation.

  6. Older drivers' risks of at-fault motor vehicle collisions.

    Science.gov (United States)

    Ichikawa, Masao; Nakahara, Shinji; Taniguchi, Ayako

    2015-08-01

    In aging societies, increasing numbers of older drivers are involved in motor vehicle collisions (MVCs), and preserving their safety is a growing concern. In this study, we focused on whether older drivers were more likely to cause MVCs and injuries than drivers in other age groups. To do so we compared at-fault MVC incidence and resulting injury risks by drivers' ages, using data from Japan, a country with a rapidly aging population. The at-fault MVC incidence was calculated based on distance traveled made for non-commercial purposes, and the injury risks posed to at-fault drivers and other road users per at-fault MVCs. We used MVC data for 2010 from the National Police Agency of Japan and driving exposure data from the Nationwide Person Trip Survey conducted by a Japanese governmental ministry in 2010. The at-fault MVC incidence showed a U-shaped curve across the drivers' ages, where teenage and the oldest drivers appeared to be the highest risk groups in terms of causing MVCs, and the incidence was higher for female drivers after age 25. The injury risk older drivers posed to other vehicle occupants because of their at-fault MVCs was lower than for drivers in other age groups, while their own injury risk appeared much higher. As the number of older drivers is increasing, efforts to reduce their at-fault MVCs appear justified. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Success drivers of sports crowdfunding campaigns

    OpenAIRE

    Brochado, A.

    2017-01-01

    Crowdfunding combines social networking with microfinance in a method of financing new ventures that has become increasingly popular. Crowdfunding offers entrepreneurs an opportunity to find a large number of investors for projects, but many campaigns tend to remain unfunded. This study’s main objective was to access the main success drivers of crowdfunded projects, focusing, in particular, on sports projects. The dataset comprised 4,952 donationand rewards-based projects launched in three pl...

  8. Drivers of productivity in Vietnamese SMEs

    DEFF Research Database (Denmark)

    Calza, Elisa; Goedhuys, Micheline; Trifkovic, Neda

    2017-01-01

    innovation (product and process) and other variables related to technological capabilities, international standards are still conducive to higher productivity, through improved management practices associated with their adoption. In line with the requirement of continuous improvement implied by most......Using a rich panel dataset of SMEs active in the manufacturing sector in Viet Nam, this paper investigates the drivers of firm productivity, focusing on the role played by international management standards certification. We develop and test the hypothesis that, controlling for technological...

  9. CORRUPTION IN FOOTBALL: MECHANISMS, ACTORS AND DRIVERS

    OpenAIRE

    Stranden, Ole; Fjeldsgård, Espen

    2016-01-01

    Master thesis Business Administration - University of Agder 2016 Corruption has existed since the beginning of time, and the first documented case of corruption related to sport took place 388 years BC. Several previous studies and research conclude that corruption appears in sport, and that it is a major problem. However, there are relatively few studies emphasising the main actors, mechanisms and drivers and that seek to find feasible solutions on how to prevent and decrease corruption i...

  10. Review of advanced driver assistance systems (ADAS)

    Science.gov (United States)

    Ziebinski, Adam; Cupek, Rafal; Grzechca, Damian; Chruszczyk, Lukas

    2017-11-01

    New cars can be equipped with many advanced safety solutions. Airbags, seatbelts and all of the essential passive safety parts are standard equipment. Now cars are often equipped with new advanced active safety systems that can prevent accidents. The functions of the Advanced Driver Assistance Systems are still growing. A review of the most popular available technologies used in ADAS and descriptions of their application areas are discussed in this paper.

  11. Multiprogrammation fast branch driver for microcomputer MICRAL

    International Nuclear Information System (INIS)

    Kaiser, Josef; Lacroix, Jean.

    1975-01-01

    This branch driver allows in association with the FIFO memories of the microcomputer Micral, very fast exchanges with the 7 crates of a CAMAC branch. A CAMAC programm (command, test, read, write) is loaded in the 1K FIFO buffer of the Micral before execution time and executed in sequence at a rate of 1,5μs per CAMAC command. After programm execution, data may be transferred directly on a magnetic tape [fr

  12. Laser dazzling impacts on car driver performance

    Science.gov (United States)

    Steinvall, Ove; Sandberg, Stig; Hörberg, Ulf; Persson, Rolf; Berglund, Folke; Karslsson, Kjell; Öhgren, Johan; Yu, Zhaohua; Söderberg, Per

    2013-10-01

    A growing problem for the Police and Security Forces has been to prevent potentially hostile individuals to pass a checkpoint, without using lethatl violence. Therefore the question has been if there is a laser or any other strong light source that could be used as a warning and dazzling device, without lethal or long term effects. To investigate the possibilities a field trial has been performed at a motor-racing track. A green CW laser with an irradiance on the eye of maximum 0.5 MPE, as defined by ICNIRP [1] and the ANZI standard [2], was used as a dazzle source. Ten drivers have been driving with dipped headlights through a course of three lines with orange cones. In every line there has been only one gate wide enough to pass without hitting the cones. The time through the course, the choice of gates and the number of cones hit have been measured. For every second trial drive through the track, the driver was exposed to the laser dazzler. The background illuminances ranged from a thousand lux in daylight to about ten millilux in darkness. The protective effect of the sun-visor of the car was investigated. The drives visual system was carefully examined before and after experimental driving and a few weeks after the experimental driving to verify that no pathological effects, that could potentially be induced by the laser exposure, pre-existed or occurred after the laser exposure. An analysis of variance for a within subjects design has been used for evaluation. It was found that green laser light can have an obvious warning effect in daylight. Dazzling does reduce the drivers ability to make judgments and manouver the car in twilight and darkness. A sun-visor can reduce the glare and give the driver an improved control, but that perception can be unjustified. No damage to the visual system was observed.

  13. Vehicle Dynamics Approach to Driver Warning

    Directory of Open Access Journals (Sweden)

    Youssef A. Ghoneim

    2013-01-01

    Full Text Available This paper discusses a concept for enhanced active safety by introducing a driver warning system based on vehicle dynamics that predicts a potential loss of control condition prior to stability control activation. This real-time warning algorithm builds on available technologies such as the Electronic Stability Control (ESC. The driver warning system computes several indices based on yaw rate, side-slip velocity, and vehicle understeer using ESC sensor suite. An arbitrator block arbitrates between the different indices and determines the status index of the driving vehicle. The status index is compared to predetermined stability levels which correspond to high and low stability levels. If the index exceeds the high stability level, a warning signal (haptic, acoustic, or visual is issued to alert the driver of a potential loss of control and ESC activation. This alert will remain in effect until the index is less than the low stability level at which time the warning signal will be terminated. A vehicle speed advisory algorithm is integrated with the warning algorithm to provide a desired vehicle speed of a vehicle traveling on a curve. Simulation results and vehicle tests were conducted to illustrate the effectiveness of the warning algorithm.

  14. Advances of energy drivers at Osaka

    International Nuclear Information System (INIS)

    Kato, Yoshiaki; Nakai, Sadao; Yamanaka, Chiyoe.

    1979-01-01

    The energy driver development at the Institute of Laser Engineering (ILE), Osaka University, comprises three fields; glass, laser, carbon dioxide laser, and relativistic electron beam. The development of reliable glass lasers has been the main program at ILE. The GEKKO 12 module program was carried out in the fiscal years from 1977 to 1979 in order to develop various laser components and subsystems which are necessary to construct a 20 kJ GEKKO 12 glass laser. The measured gain coefficient of the 200 mm disk amplifier was 0.10/cm corresponding to the αD product of 4.0. The expected peak output power of the system was 2 TW at 0.1 ns and 0.9 kJ at 1 ns. The recent advances in coating techniques will enable to operate this system over 1.3 kJ per beam at 3 ns. Carbon dioxide lasers have been developed as efficient high energy lasers to study the wave length scaling of implosion process. The design and construction of the 10 kJ LEKKO 8 laser system are in progress. Relativistic electron beam machines, being the most cost-effective driver, have been studied to control pulsed power and to investigate electron beam plasma interaction. As the future plans of ILE, the construction of a 100 kJ energy driver from 1958 to 1987 for scientific break-even experiments is considered. (Kato, T.)

  15. Underlying substance abuse problems in drunk drivers.

    Science.gov (United States)

    Snenghi, Rossella; Forza, Giovanni; Favretto, Donata; Sartore, Daniela; Rodinis, Silvia; Terranova, Claudio; Nalesso, Alessandro; Montisci, Massimo; Ferrara, Santo Davide

    2015-01-01

    The aim of this study was to investigate polydrug use in drunk drivers. The experimental study was conducted on 2,072 drunk drivers undergoing a driving license reissue protocol at the Department of Legal Medicine of Padova University Hospital in the period between January 2011 and December 2012. The study protocol involved anamnesis, clinical examination, toxicological history, and toxicological analyses on multiple biological samples. One thousand eight hundred seventy-seven subjects (90.6%) were assessed as fit to drive, and 195 (9.5%) were declared unfit. Among those unfit, 32 subjects (1.6%) were declared unfit due to recent use of an illicit drug (time span drive after completeness of the protocol was established in 1.2% of cases for alcohol disorders and in 5.7% of cases for illicit drug abuse; only one subject was included in both subgroups. Cocaine was the most widely used substance, followed by cannabis, opiates, and psychotropic pharmaceutical drugs. The application of the protocol presented in this study allowed the identification of underlying polydrug use in drunk drivers. The study led to the identification of 6.8% unfit subjects on the basis of alcohol disorders and/or drug abuse, compared to 1.2% of identifiable unfitness if the protocol were limited to the mere assessment of alcohol consumption. The frequent association of alcohol and cocaine is different from other patterns of use in North Europe countries.

  16. Multiple-Unit MRE Leak Detector

    National Research Council Canada - National Science Library

    Litman, Neal

    2000-01-01

    ... testing configuration, materials handling and data collection, and cost benefits. This STP uses the baseline leak detection system, ATC-3, and determine the impact of such variables as pouch temperature and cartoning...

  17. Subsistence Meal Ready to Eat (MRE)

    Science.gov (United States)

    1993-04-01

    UHT ) milk which requires no refrigeration. Granted warm UHT milk is not very palatable but it remains useable without constant cooling. Technology...pork or 1 pound of salt fish; 1 pound of bread or flour; 1 pint of milk or payment of 1/72 dollars, and 1 quart of cider or spruce beer; 3 pints of...DOD sources. Outreach programs of this nature are still in their infancy. 8 NEW TECHNOLOGY- UHT , Radiation, Electric Shock. Much has changed since the

  18. Mandatory Physician Reporting of At-Risk Drivers: The Older Driver Example.

    Science.gov (United States)

    Agimi, Yll; Albert, Steven M; Youk, Ada O; Documet, Patricia I; Steiner, Claudia A

    2017-01-09

    In a number of states, physicians are mandated by state law to report at-risk drivers to licensing authorities. Often these patients are older adult drivers who may exhibit unsafe driving behaviors, have functional/cognitive impairments, or are diagnosed with conditions such as Alzheimer's disease and/or seizure disorders. The hypothesis that mandatory physician reporting laws reduce the rate of crash-related hospitalizations among older adult drivers was tested. Using retrospective data (2004-2009), this study identified 176,066 older driver crash-related hospitalizations, from the State Inpatient Databases. Three age-specific negative binomial generalized estimating equation models were used to estimate the effect of physician reporting laws on state's incidence rate of crash-related hospitalizations among older drivers. No evidence was found for an independent association between mandatory physician reporting laws and a lower crash hospitalization rate among any of the age groups examined. The main predictor of interest, mandatory physician reporting, failed to explain any significant variation in crash hospitalization rates, when adjusting for other state-specific laws and characteristics. Vision testing at in-person license renewal was a significant predictor of lower crash hospitalization rate, ranging from incidence rate ratio of 0.77 (95% confidence interval 0.62-0.94) among 60- to 64-year olds to 0.83 (95% confidence interval 0.67-0.97) among 80- to 84-year olds. Physician reporting laws and age-based licensing requirements are often at odds with older driver's need to maintain independence. This study examines this balance and finds no evidence of the benefits of mandatory physician reporting requirements on driver crash hospitalizations, suggesting that physician mandates do not yet yield significant older driver safety benefits, possibly to the detriment of older driver's well-being and independence. © The Author 2017. Published by Oxford University

  19. Driver sleepiness on YouTube: A content analysis.

    Science.gov (United States)

    Hawkins, A N; Filtness, A J

    2017-02-01

    Driver sleepiness is a major contributor to severe crashes and fatalities on our roads. Many people continue to drive despite being aware of feeling tired. Prevention relies heavily on education campaigns as it is difficult to police driver sleepiness. The video sharing social media site YouTube is extremely popular, particularly with at risk driver demographics. Content and popularity of uploaded videos can provide insight into the quality of publicly accessible driver sleepiness information. The purpose of this research was to answer two questions; firstly, how prevalent are driver sleepiness videos on YouTube? And secondly, what are the general characteristics of driver sleepiness videos in terms of (a) outlook on driver sleepiness, (b) tone, (c) countermeasures to driver sleepiness, and, (d) driver demographics. Using a keywords search, 442 relevant videos were found from a five year period (2nd December 2009-2nd December 2014). Tone, outlook, and countermeasure use were thematically coded. Driver demographic and video popularity data also were recorded. The majority of videos portrayed driver sleepiness as dangerous. However, videos that had an outlook towards driver sleepiness being amusing were viewed more often and had more mean per video comments and likes. Humorous videos regardless of outlook, were most popular. Most information regarding countermeasures to deal with driver sleepiness was accurate. Worryingly, 39.8% of videos with countermeasure information contained some kind of ineffective countermeasure. The use of humour to convey messages about the dangers of driver sleepiness may be a useful approach in educational interventions. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Fusion of optimized indicators from Advanced Driver Assistance Systems (ADAS) for driver drowsiness detection.

    Science.gov (United States)

    Daza, Iván García; Bergasa, Luis Miguel; Bronte, Sebastián; Yebes, Jose Javier; Almazán, Javier; Arroyo, Roberto

    2014-01-09

    This paper presents a non-intrusive approach for monitoring driver drowsiness using the fusion of several optimized indicators based on driver physical and driving performance measures, obtained from ADAS (Advanced Driver Assistant Systems) in simulated conditions. The paper is focused on real-time drowsiness detection technology rather than on long-term sleep/awake regulation prediction technology. We have developed our own vision system in order to obtain robust and optimized driver indicators able to be used in simulators and future real environments. These indicators are principally based on driver physical and driving performance skills. The fusion of several indicators, proposed in the literature, is evaluated using a neural network and a stochastic optimization method to obtain the best combination. We propose a new method for ground-truth generation based on a supervised Karolinska Sleepiness Scale (KSS). An extensive evaluation of indicators, derived from trials over a third generation simulator with several test subjects during different driving sessions, was performed. The main conclusions about the performance of single indicators and the best combinations of them are included, as well as the future works derived from this study.

  1. Fusion of Optimized Indicators from Advanced Driver Assistance Systems (ADAS for Driver Drowsiness Detection

    Directory of Open Access Journals (Sweden)

    Iván G. Daza

    2014-01-01

    Full Text Available This paper presents a non-intrusive approach for monitoring driver drowsiness using the fusion of several optimized indicators based on driver physical and driving performance measures, obtained from ADAS (Advanced Driver Assistant Systems in simulated conditions. The paper is focused on real-time drowsiness detection technology rather than on long-term sleep/awake regulation prediction technology. We have developed our own vision system in order to obtain robust and optimized driver indicators able to be used in simulators and future real environments. These indicators are principally based on driver physical and driving performance skills. The fusion of several indicators, proposed in the literature, is evaluated using a neural network and a stochastic optimization method to obtain the best combination. We propose a new method for ground-truth generation based on a supervised Karolinska Sleepiness Scale (KSS. An extensive evaluation of indicators, derived from trials over a third generation simulator with several test subjects during different driving sessions, was performed. The main conclusions about the performance of single indicators and the best combinations of them are included, as well as the future works derived from this study.

  2. Work fatigue in urban bus drivers

    Directory of Open Access Journals (Sweden)

    Teresa Makowiec-Dąbrowska

    2015-10-01

    Full Text Available Background: Bus drivers are a special group of professional drivers who are at a very high risk of fatigue. The aim of the study was to examine whether the driver’s subjective assessment of fatigue allows for the determination of its level and identification of its causes. Material and Methods: The study group comprised 45 randomly selected bus drivers (mean age – 43.7±7.9 years, period of employment as drivers – 14.7±8.6 years. Examinations were performed in all subjects four times – before and after work on the “easy” route (outside the city center, small traffic intensity and before and after work on the “difficult” route (city center, heavy traffic. The fatigue test questionnaire, based on the list of symptoms of fatigue prepared by the Japan Research Committee of Fatigue, was used in the study. Results: The rating of fatigue after the work was significantly higher than that before the work. The profile of fatigue after work was not influenced by the type of route, but the assessment of most symptoms of fatigue reached a higher level after the “difficult” routes and the differences were statistically significant for 7 symptoms. Only the ratings of leg fatigue, feeling of heaviness, and the necessity to squint eyes and gaze with effort reached the higher levels after driving the “easy” routes. It has been found that the level of fatigue was significantly correlated with the job characteristics (driving time, the length of the route, number of stops, etc. and with the abundance of food ingested and type of beverage (coffee vs. others drunk prior to driving. Conclusions: The questionnaire used in our study to assess the subjective feeling of fatigue has proved to be a sensitive and useful tool for indicating the level and causes of fatigue. The relationship between the symptoms of fatigue and the characteristics of job and lifestyle shows that actions must be taken by both the employers and employees to prevent fatigue

  3. Environmental Drivers of Variation in Bleaching Severity of Acropora Species during an Extreme Thermal Anomaly

    OpenAIRE

    Mia O. Hoogenboom; Mia O. Hoogenboom; Grace E. Frank; Grace E. Frank; Tory J. Chase; Tory J. Chase; Saskia Jurriaans; Saskia Jurriaans; Mariana Álvarez-Noriega; Mariana Álvarez-Noriega; Katie Peterson; Kay Critchell; Kathryn L. E. Berry; Kathryn L. E. Berry; Kathryn L. E. Berry

    2017-01-01

    High sea surface temperatures caused global coral bleaching during 2015–2016. During this thermal stress event, we quantified within- and among-species variability in bleaching severity for critical habitat-forming Acropora corals. The objective of this study was to understand the drivers of spatial and species-specific variation in the bleaching susceptibility of these corals, and to evaluate whether bleaching susceptibility under extreme thermal stress was consistent with that observed duri...

  4. A learning-based autonomous driver: emulate human driver's intelligence in low-speed car following

    Science.gov (United States)

    Wei, Junqing; Dolan, John M.; Litkouhi, Bakhtiar

    2010-04-01

    In this paper, an offline learning mechanism based on the genetic algorithm is proposed for autonomous vehicles to emulate human driver behaviors. The autonomous driving ability is implemented based on a Prediction- and Cost function-Based algorithm (PCB). PCB is designed to emulate a human driver's decision process, which is modeled as traffic scenario prediction and evaluation. This paper focuses on using a learning algorithm to optimize PCB with very limited training data, so that PCB can have the ability to predict and evaluate traffic scenarios similarly to human drivers. 80 seconds of human driving data was collected in low-speed (car-following scenarios. In the low-speed car-following tests, PCB was able to perform more human-like carfollowing after learning. A more general 120 kilometer-long simulation showed that PCB performs robustly even in scenarios that are not part of the training set.

  5. X3 expansion tube driver gas spectroscopy and temperature measurements

    Science.gov (United States)

    Parekh, V.; Gildfind, D.; Lewis, S.; James, C.

    2017-11-01

    The University of Queensland's X3 facility is a large, free-piston driven expansion tube used for super-orbital and high Mach number scramjet aerothermodynamic studies. During recent development of new scramjet test flow conditions, experimentally measured shock speeds were found to be significantly lower than that predicted by initial driver performance calculations. These calculations were based on ideal, isentropic compression of the driver gas and indicated that loss mechanisms, not accounted for in the preliminary analysis, were significant. The critical determinant of shock speed is peak driver gas sound speed, which for a given gas composition depends on the peak driver gas temperature. This temperature may be inaccurately estimated if an incorrect fill temperature is assumed, or if heat losses during driver gas compression are significant but not accounted for. For this study, the ideal predicted peak temperature was 3750 K, without accounting for losses. However, a much lower driver temperature of 2400 K is suggested based on measured experimental shock speeds. This study aimed to measure initial and peak driver gas temperatures for a representative X3 operating condition. Examination of the transient temperatures of the driver gas and compression tube steel wall during the initial fill process showed that once the filling process was complete, the steady-state driver gas temperature closely matched the tube wall temperature. Therefore, while assuming the gas is initially at the ambient laboratory temperature is not a significant source of error, it can be entirely mitigated by simply monitoring tube wall temperature. Optical emission spectroscopy was used to determine the driver gas spectra after diaphragm rupture; the driver gas emission spectrum exhibited a significant continuum radiation component, with prominent spectral lines attributed to contamination of the gas. A graybody approximation of the continuum suggested a peak driver gas temperature of

  6. Deep Learning-Based Gaze Detection System for Automobile Drivers Using a NIR Camera Sensor.

    Science.gov (United States)

    Naqvi, Rizwan Ali; Arsalan, Muhammad; Batchuluun, Ganbayar; Yoon, Hyo Sik; Park, Kang Ryoung

    2018-02-03

    A paradigm shift is required to prevent the increasing automobile accident deaths that are mostly due to the inattentive behavior of drivers. Knowledge of gaze region can provide valuable information regarding a driver's point of attention. Accurate and inexpensive gaze classification systems in cars can improve safe driving. However, monitoring real-time driving behaviors and conditions presents some challenges: dizziness due to long drives, extreme lighting variations, glasses reflections, and occlusions. Past studies on gaze detection in cars have been chiefly based on head movements. The margin of error in gaze detection increases when drivers gaze at objects by moving their eyes without moving their heads. To solve this problem, a pupil center corneal reflection (PCCR)-based method has been considered. However, the error of accurately detecting the pupil center and corneal reflection center is increased in a car environment due to various environment light changes, reflections on glasses surface, and motion and optical blurring of captured eye image. In addition, existing PCCR-based methods require initial user calibration, which is difficult to perform in a car environment. To address this issue, we propose a deep learning-based gaze detection method using a near-infrared (NIR) camera sensor considering driver head and eye movement that does not require any initial user calibration. The proposed system is evaluated on our self-constructed database as well as on open Columbia gaze dataset (CAVE-DB). The proposed method demonstrated greater accuracy than the previous gaze classification methods.

  7. Using shadow page cache to improve isolated drivers performance.

    Science.gov (United States)

    Zheng, Hao; Dong, Xiaoshe; Wang, Endong; Chen, Baoke; Zhu, Zhengdong; Liu, Chengzhe

    2015-01-01

    With the advantage of the reusability property of the virtualization technology, users can reuse various types and versions of existing operating systems and drivers in a virtual machine, so as to customize their application environment. In order to prevent users' virtualization environments being impacted by driver faults in virtual machine, Chariot examines the correctness of driver's write operations by the method of combining a driver's write operation capture and a driver's private access control table. However, this method needs to keep the write permission of shadow page table as read-only, so as to capture isolated driver's write operations through page faults, which adversely affect the performance of the driver. Based on delaying setting frequently used shadow pages' write permissions to read-only, this paper proposes an algorithm using shadow page cache to improve the performance of isolated drivers and carefully study the relationship between the performance of drivers and the size of shadow page cache. Experimental results show that, through the shadow page cache, the performance of isolated drivers can be greatly improved without impacting Chariot's reliability too much.

  8. Truck Drivers And Risk Of STDs Including HIV

    Directory of Open Access Journals (Sweden)

    Bansal R.K

    1995-01-01

    Full Text Available Research Question: Whether long distance truck drivers are at a higher risk of contracting and transmitting STDs including HIV? Objectives: i To study the degree of knowledge of HIV and AIDS among long- distance truck drivers. ii Assess their sexual behaviour including condom use. iii Explore their prevailing social influences and substance abuse patterns. iv Explore their treatment seeking bahaviour as regards STDs. v Deduce their risk of contracting and transmitting STDs including HIV. Study Design: Cross- sectional interview. Setting: Transport Nagar, Indore (M.P Participants: 210 senior drivers (First drivers and 210 junior drivers (Second drivers. Study Variables: Extra-Marital sexual intercourse, condom usage, past and present history of STDs, treatment and counseling, substance abuse, social â€" cultural milieu. Outcome Variables: Risk of contraction of STDs. Statistical Analysis: Univariate analysis. Results: 94% of the drivers were totally ignorant about AIDS. 82.9% and 43.8 % of the senior and junior drivers had a history of extra- marital sex and of these only 2 regularly used condoms. 13.8% and 3.3 % of the senior and junior drivers had a past or present history suggestive of STD infection. Alcohol and Opium were regularly used by them. Conclusion: The studied drivers are at a high risk of contracting and transmitting STDs including HIV.

  9. Static Anthropometric Characteristics of Bangladeshi Vehicle Driver: A Case Study.

    Science.gov (United States)

    Halder, P K; Sarker, E

    2016-01-01

    Background. Inappropriate design of sitting furniture and working equipment causes the serious musculoskeletal injuries and various pains as well as reducing working efficiency. Uncomfortable sitting posture in prolonged driving in Bangladesh is an issue to be solved immediately. Therefore, anthropometric databank of user population is significantly essential for the suitable dimensional design for avoiding these remarkable problems. Methods. This study analyses the anthropometric data of the Bangladeshi male vehicle driver aged between 30 and 60 years. A total of 210 Bangladeshi healthy drivers are considered for 15 anthropometric measurements and compared with the similar anthropometrics of other nationalities. Results. The mean stature and sitting height erect of Bangladeshi driver are 1645 mm and 843 mm, respectively. The mean of body mass index (BMI) of the drivers is 26.09 kg/m(2), which indicates that the drivers are overweight. The mean stature of Bangladeshi driver is 17 mm shorter than the driver of Korea and 115 mm shorter than the driver of Iran. Conclusion. There are substantial differences between the body dimensions of Bangladeshi driver and similar dimensions of other countries. In comparison, Bangladeshi driver is found to be the shortest compared with the sample of other nationalities.

  10. Sensory properties and drivers of liking for Greek yogurts.

    Science.gov (United States)

    Desai, N T; Shepard, L; Drake, M A

    2013-01-01

    Greek yogurt is currently the largest growing sector in the dairy industry. Because no standard of identity exists for Greek yogurts in the United States, and they can be made by a variety of methods, variability in sensory properties is expected. Knowledge of consumer perception and specific drivers of liking will be useful information for product developers. The objective of this study was to document the sensory properties of commercial Greek yogurts and to determine drivers of liking through descriptive profiling and consumer testing. Flavor and texture attributes of commercial Greek yogurts (n = 24) were evaluated in triplicate by a trained descriptive sensory panel. An online survey (n = 520) was used to collect consumer usage and attitude information for Greek yogurts before consumer acceptance testing. Consumer acceptance testing (n = 155) was then conducted on commercial Greek yogurts (n = 10). Univariate and multivariate statistical analyses were used for data analysis. Sensory properties of yogurt differed with fat content and manufacture (Greek vs. fortified Greek). Full-fat yogurts were characterized by firmness and denseness, whereas low- and non-fat yogurts lacked firmness, denseness, cohesiveness, and, after stirring, viscosity. Fortified Greek yogurts generally had more surface shine and jiggle and lower denseness compared with traditional Greek yogurts. Fewer flavor differences were observed among yogurts compared with texture differences. Fortified Greek yogurts displayed a burnt/beefy flavor not documented in traditional Greek yogurts, but this flavor was not evident in all fortified Greek yogurts. Consumer preferred Greek yogurts with firm, dense texture, moderate sweet aromatic, milkfat and dairy sour flavors, and moderate sour taste. Consumers were aware of the increased protein content of Greek yogurts but generally unaware of differences between strained and fortified Greek yogurts; both strained Greek and fortified Greek yogurts received

  11. The prevalence of drugs in injured drivers.

    Science.gov (United States)

    Drummer, Olaf H; Kourtis, Irene; Beyer, Jochen; Tayler, Penny; Boorman, Martin; Gerostamoulos, Dimitri

    2012-02-10

    In mid 2009 Victoria introduced compulsory drug testing of blood taken from all injured drivers taken to hospital. Δ(9)-Tetrahydrocannabinol (THC), methylamphetamine (MA) and 3,4-methylenedioxy-methylamphetamine (MDMA) are prohibited and if drivers are positive to any amount an automatic penalty is enforced. Laboratory screens were conducted on preserved blood using ELISA testing for cannabis metabolite and methylamphetamines and a fully validated LC-MS/MS method for 105 drugs including THC, amphetamines, opioids, benzodiazepines, antidepressants and antipsychotics and a number of other psychoactive substances using a minimum of two transitions per drug. Conventional GC-testing for ethanol was used to screen and quantify the presence of alcohol. 1714 drivers were tested and showed alcohol in 29% (≥ 0.01 g/100mL) and drugs in 35%. The positive rate for the three drugs prohibited by legislation was 12.5%. The prevalence of THC, MA and MDMA was 9.8%, 3.1%, and 0.8%, respectively. The range of THC concentrations in blood was 2-42 ng/mL (median 7) of which 70% had a concentration of 10 ng/mL or higher. The range of concentrations for MA and MDMA was 0.02-0.4 and 0.03-0.3mg/L (median for both drugs was 0.05 mg/L). Drugs of any type were detected in 35% of cases. The other drugs were largely prescribed drugs such as the antidepressants (9.3%) and benzodiazepines (8.9%). Neither 6-acetylmorphine nor cocaine (or benzoylecgonine) was detected in these cases. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  12. Global drivers, sustainable manufacturing and systems ergonomics.

    Science.gov (United States)

    Siemieniuch, C E; Sinclair, M A; Henshaw, M J deC

    2015-11-01

    This paper briefly explores the expected impact of the 'Global Drivers' (such as population demographics, food security; energy security; community security and safety), and the role of sustainability engineering in mitigating the potential effects of these Global Drivers. The message of the paper is that sustainability requires a significant input from Ergonomics/Human Factors, but the profession needs some expansion in its thinking in order to make this contribution. Creating a future sustainable world in which people experience an acceptable way of life will not happen without a large input from manufacturing industry into all the Global Drivers, both in delivering products that meet sustainability criteria (such as durability, reliability, minimised material requirement and low energy consumption), and in developing sustainable processes to deliver products for sustainability (such as minimum waste, minimum emissions and low energy consumption). Appropriate changes are already being implemented in manufacturing industry, including new business models, new jobs and new skills. Considerable high-level planning around the world is in progress and is bringing about these changes; for example, there is the US 'Advanced Manufacturing National Program' (AMNP)', the German 'Industrie 4.0' plan, the French plan 'la nouvelle France industrielle' and the UK Foresight publications on the 'Future of Manufacturing'. All of these activities recognise the central part that humans will continue to play in the new manufacturing paradigms; however, they do not discuss many of the issues that systems ergonomics professionals acknowledge. This paper discusses a number of these issues, highlighting the need for some new thinking and knowledge capture by systems ergonomics professionals. Among these are ethical issues, job content and skills issues. Towards the end, there is a summary of knowledge extensions considered necessary in order that systems ergonomists can be fully

  13. Drivers for animal welfare policies in Europe.

    Science.gov (United States)

    Dalla Villa, P; Matthews, L R; Alessandrini, B; Messori, S; Migliorati, G

    2014-04-01

    The European region has been, and remains, a global leader in the development of animal welfare policies. The region has a great diversity of cultures and religions, different levels of socio-economic development, and varied legislation, policies and practices. Nevertheless, there are common drivers for animal welfare policy based on a history of animal welfare ethics and obligations to animal users and society in general. A unifying goal of countries in the region is to achieve sustainable compliance with the World Organisation for Animal Health (OIE) standards on animal health and welfare. Ethics isthe overarching driver, supported by the actions of governmental, inter-governmental and non-governmental activities, markets and trade, science and knowledge. Historically, organisations involved in promoting animal welfare have tended to act in isolation. For example, non-governmental organisations (NGOs) have run campaigns to influence retailers and the welfare policies of their farmer suppliers. Increasingly, different organisations with common or complementary goals are working together. For example, competent authorities, inter-governmental bodies and NGOs have combined their efforts to address dog population control across several countries in the region. Also, animal welfare is becoming integrated into the corporate social responsibility targets of private companies. Science and knowledge, as drivers and tools, are assisting with the harmonisation of welfare standards, e.g. by providing a common basis for measuring welfare impacts through animal-based measures and widespread sharing of this information. Current trends suggest that there will be greater collaboration among the organisations driving change, and increasing convergence of animal welfare strategies and welfare assessment tools. The result will be increased harmonisation of animal welfare standards throughout the region.

  14. Depicting CH4 fluxes and drivers dynamics

    Science.gov (United States)

    Dengel, S.; Billesbach, D. P.; Hughes, H.; Humphreys, E.; Lee, J.; Noormets, A.; Verfaillie, J. G.

    2016-12-01

    Since the advancement in CH4 eddy covariance flux measurements, monitoring of CH4 emissions is becoming more widespread. Since CH4 fluxes are not as predictable or as easily interpretable as CO2 fluxes, understanding their emission patterns often still challenging. As these are spatially (ecosystem and latitudinal) and temporal very divers and often event based, a better understanding or interpretation of results is required. An improvement in understanding does also increase the reliability of gap-filling methods as annual greenhouse gas budgets rely on high quality data. There are generalised additive models (Wood 2001) that can easily be applied to sites, models where a relationship between the response variable, in this case CH4 and explanatory variables (drivers) is established. Relevant for CH4flux dynamics are the smoothing function that is applied, where each predictor variable is separated into sections and a polynomial function fitted. On the one hand such models are rarely used as they are difficult to interpret since no parameter values are retuned. On the other hand, such models are very good for prediction and explanatory analysis in estimating the functional nature of a response. Applying such models to CH4 eddy flux data does improve our understanding of the dynamics of CH4 emissions and the respective meteorological drivers. Furthermore, such models combined with tree models (interactions between the explanatory variables), can visualise precise dynamics and easily applied to individual sites. These models are simple tools in understanding of these complex fluxes, as they can include a variety of drivers, and their relevance tested by the model. Model input variables should be as independent as possible (avoiding cross-correlation), avoiding redundant inputs, as models should follow the principle of parsimony of being simple but not too simple. Wood SN (2001). mgcv: GAMs and generalized ridge regression for R. R news.

  15. Effects of planar and non-planar driver-side mirrors on age-related discomfort-glare responses

    Science.gov (United States)

    Lockhart, Thurmon E.; Atsumi, Bunji; Ghosh, Arka; Mekaroonreung, Haruetai; Spaulding, Jeremy

    2010-01-01

    In this study, we evaluated subjective nighttime discomfort-glare responses on three different types of planar and non-planar driver-side mirrors on two age groups. Fifty-six individuals (28 young [18–35 years] and 28 old [65 years and over]) participated in this experiment. Subjective discomfort-glare rating scores on three different types of driver-side mirrors were assessed utilizing De Boer's rating scale in a controlled nighttime driving environment (laboratory ambient illuminant level—l lux with headlight turned off). Three driver-side mirrors included planar “flat mirror”: radius of curvature 242650.92 mm, reflectivity 0.60114, and surface reflectance 0.60568; “curved mirror”: radius of curvature 1433.3 mm, reflectivity 0.21652, and surface reflectance 0.58092; “blue mirror”: radius of curvature 1957.1 mm, reflectivity 0.25356, and surface reflectance 0.54585. The results indicated that with the same glare level (as measured by angle of incidence and illuminance in front of the eyes), older adults reported worse feelings of glare than their younger counterparts. Furthermore, the results indicated that both young and older adults reported worse feelings of glare for planar driver-side mirror than non-planar driver-side mirrors. These results suggest that older adults' criterion of discomfort-glare is more sensitive than their younger counterparts, and importantly, the non-planar driver-side mirrors can be beneficial in terms of reducing nighttime discomfort-glare for both the young and the elderly. PMID:20582252

  16. Drowsy Driver Detection via Steering Wheel

    Directory of Open Access Journals (Sweden)

    Herlina ABDUL RAHIM

    2010-09-01

    Full Text Available The main purpose of this project is to produce a safety system especially for fatigue car driver so as to prevent from accidents. The statistic on road fatality shows that human error constitute of 64.84 % road accidents fatality and 17.4 % due to technical factors. These systems encompassed the approach of hand pressure applied on the steering wheel. The steering will be installed with pressure sensors. At the same time these sensors can be used to measure gripping force while driving.

  17. Driver reactions on ecological feedback via different HMI modalities

    OpenAIRE

    Staubach, Maria; Kassner, Astrid; Fricke, Nicola; Schießl, Caroline; Brockmann, Martin; Kuck, Detlef

    2012-01-01

    Nowadays there already exists a large amount of driving-related information displayed in the dashboard and thus additional information concerning ecological driving might enlarge the workload of the driver further. This raises the question whether the presentation of additional ecologic information via the haptic channel is more efficient and comfortable for the driver compared to a visual presentation. Previous studies proved the impact of driver feedback systems on the reduction of fuel con...

  18. Driving Rehabilitation Programs for Older Drivers in the United States

    OpenAIRE

    Betz, Marian E.; Dickerson, Anne; Coolman, Tyler; Davis, Elin Schold; Jones, Jacqueline; Schwartz, Robert

    2014-01-01

    The objective of this study was to describe the services, referral and reporting practices, and barriers to utilization of driver rehabilitation programs (DRPs) for older drivers. Identified through two national association databases, 204 driver rehabilitation programs completed an online survey. DRP availability varies, with a median of one program per 64,151 older adults (range: 1,006–676,981). The median cost for a complete evaluation was $400; 36% of DRPs reported no third-party reimburse...

  19. Taxi driver seat belt wearing in Nanjing, China.

    Science.gov (United States)

    Routley, Virginia; Ozanne-Smith, Joan; Qin, Yu; Wu, Ming

    2009-01-01

    To determine and validate patterns of seat belt use and attitudes of taxi drivers on wearing a seat belt following national and provincial seat belt legislation in 2004-2005. Roadside daylight seat belt observation and interview survey methods were used, as well as observations from inside taxis during routine trips and a taxi driver focus group. The setting was Nanjing, Jiangsu Province, PR China in April of 2006 and 2007. Prevalence of seat belt use and attitudes to wearing a seat belt were determined, as were vehicle and driver characteristics, and comparisons with other motor-vehicle driver's seat belt use and attitudes. Taxi drivers interviewed were predominantly male and aged 30-39 years. They spent more hours per week in their vehicles and had more driving experience than other drivers. Over half (56.2%) of taxi drivers interviewed reported that they always wore seat belts, while observation of taxi drivers showed lower wearing rates (i.e., roadside observation was 43.8%, and observation from inside taxis was 36.2%). Belt tampering was a practice of 12-15% of taxi drivers. "Fine avoidance, safety, high speed and long trips" were given as important reasons for wearing and "feeling trapped and uncomfortable" for not wearing. Seat belt reminder signs in taxis were common (82.6% of taxis), but did not appear to impact on driver seat belt use. The four research methods found taxi drivers to have consistently low "correct wearing" rates. As in several other countries, taxi drivers are particularly resistant to seat belt use. Innovative strategies, including occupational health and safety approaches, may be required to achieve increased levels of seat belt use.

  20. Artefacts of questionnaire-based psychological testing of drivers

    Directory of Open Access Journals (Sweden)

    Anna Łuczak

    2014-06-01

    Full Text Available Background: The purpose of this article is to draw attention to a significant role of social approval variable in the qustionnairebased diagnosis of drivers' psychological aptitude. Material and Methods: Three questionnaires were used: Formal Characteristics of Behavior - Temperament Inventory (FCB-TI, Eysenck Personality Questionnaire (EPQ-R(S and Impulsiveness Questionnaire (Impulsiveness, Venturesomeness, Empathy - IVE. Three groups of drivers were analyzed: professional "without crashes" (N = 46, nonprofessional "without crashes" (N = 75, and nonprofessional "with crashes" (N = 75. Results: Nonprofessional drivers "without crashes" significantly stood up against other drivers. Their personality profile, indicating a significantly utmost perseveration, emotional reactivity, neuroticism, impulsiveness and the lowest endurance did not fit in to the requirements to be met by drivers. The driver safety profile was characteristic of professional drivers (the lowest level of perseveration, impulsiveness and neuroticism and the highest level of endurance. Similar profile occurred among nonprofessional drivers - the offenders of road crashes. Compared to the nonprofessional "without crashes" group, professional drivers and offenders of road crashes were also characterized by a significantly higher score on the Lie scale, determining the need for social approval. This is likely to result from the study procedure according to which the result of professional drivers testing had an impact on a possible continuity of their job and that of nonprofessional drivers "with crashes" decided about possible recovery of the driving license. Conclusions: The variable of social approval can be a significant artifact in the study of psychological drivers' testing and reduce the reliability of the results of questionnaire methods. Med Pr 2014;65(3:373–385

  1. Simulator performance differences between experienced and novice bus drivers.

    OpenAIRE

    Dorn, Lisa; Stannard, Jenny

    2006-01-01

    In order to combat the problem of novice bus driver risk, a bus simulator was developed to improve decision-making at hazards that are most often associated with bus crashes. If the simulator is capable of discriminating between novice and experienced bus drivers then it can be argued that it is a valid tool for bus driver training to improve road safety. The purpose of this study then is to investigate whether there are significant differences between experienced and novice bus d...

  2. Processes, Performance Drivers and ICT Tools in Human Resources Management

    OpenAIRE

    Oškrdal Václav; Pavlíček Antonín; Jelínková Petra

    2011-01-01

    This article presents an insight to processes, performance drivers and ICT tools in human resources (HR) management area. On the basis of a modern approach to HR management, a set of business processes that are handled by today’s HR managers is defined. Consequently, the concept of ICT-supported performance drivers and their relevance in the area of HR management as well as the relationship between HR business processes, performance drivers and ICT tools are defined. The theoretical outcomes ...

  3. Occupational health risks and intervention strategies for US taxi drivers.

    Science.gov (United States)

    Murray, Kate E; Buul, Abdimalik; Aden, Rasheed; Cavanaugh, Alyson M; Kidane, Luwam; Hussein, Mikaiil; Eastman, Amelia; Checkoway, Harvey

    2017-12-02

    Research has shown that taxi drivers are at risk for numerous health concerns, such as low back and leg pain, linked to their highly sedentary occupation, long work hours and stressors related to the job (e.g. low income, safety threats). The goal of this study was to explore occupational health risks and opportunities for health interventions with taxi drivers using community-based participatory research (CBPR) methods. A mixed methods approach included first a convenience sample of 19 East African taxi drivers participating in focus group discussions. Second, a convenience sample of 75 current taxi drivers (M age = 45.7 years) and 25 non-driver comparison participants (M age = 40.3 years) were recruited to complete a structured self-reported questionnaire and objective measures of health. Health education was provided alongside the research to address common health concerns and to ensure mutual benefit and an action orientation. The focus groups described numerous health concerns that drivers attributed to their occupation, including chronic pain, sleep deprivation, cardiovascular disease, diabetes, kidney disease and eye problems, as the most common. Participants offered ideas for health interventions that include workplace reform and driver education. Quantitative data indicate that 44% of drivers reported their health as 'fair' or 'poor'. Drivers were more likely to report musculoskeletal pain, less sleep, more fatigue and less physical activity as compared to non-drivers. The majority of drivers reported financial and job dissatisfaction. The research provides data to inform targeted health interventions that support the health and safety of taxi drivers. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  4. Driver support in congestion. An assessment of user needs and impacts on driver and traffic flow

    NARCIS (Netherlands)

    van Driel, Cornelie

    2007-01-01

    Mobility is a key factor for modern societies. However, it also brings about problems, such as congestion, accidents and pollution. High expectations rest on in-vehicle systems to contribute to solving these problems. These so-called driver support systems use advanced information and communication

  5. Sitting biomechanics, part II: optimal car driver's seat and optimal driver's spinal model.

    Science.gov (United States)

    Harrison, D D; Harrison, S O; Croft, A C; Harrison, D E; Troyanovich, S J

    2000-01-01

    Driving has been associated with signs and symptoms caused by vibrations. Sitting causes the pelvis to rotate backwards and the lumbar lordosis to reduce. Lumbar support and armrests reduce disc pressure and electromyographically recorded values. However, the ideal driver's seat and an optimal seated spinal model have not been described. To determine an optimal automobile seat and an ideal spinal model of a driver. Information was obtained from peer-reviewed scientific journals and texts, automotive engineering reports, and the National Library of Medicine. Driving predisposes vehicle operators to low-back pain and degeneration. The optimal seat would have an adjustable seat back incline of 100 degrees from horizontal, a changeable depth of seat back to front edge of seat bottom, adjustable height, an adjustable seat bottom incline, firm (dense) foam in the seat bottom cushion, horizontally and vertically adjustable lumbar support, adjustable bilateral arm rests, adjustable head restraint with lordosis pad, seat shock absorbers to dampen frequencies in the 1 to 20 Hz range, and linear front-back travel of the seat enabling drivers of all sizes to reach the pedals. The lumbar support should be pulsating in depth to reduce static load. The seat back should be damped to reduce rebounding of the torso in rear-end impacts. The optimal driver's spinal model would be the average Harrison model in a 10 degrees posterior inclining seat back angle.

  6. Car drivers' perceptions of electronic stability control (ESC) systems.

    Science.gov (United States)

    Vadeby, Anna; Wiklund, Mats; Forward, Sonja

    2011-05-01

    As a way to reduce the number of car crashes different in-car safety devices are being introduced. In this paper one such application is being investigated, namely the electronic stability control system (ESC). The study used a survey method, including 2000 private car drivers (1000 driving a car with ESC and 1000 driving a car without ESC). The main objective was to investigate the effect of ESC on driver behaviour. Results show that drivers report that they drive even more carelessly when they believe that they have ESC, than when they do not. Men are more risk prone than women and young drivers more than older drivers. Using the theory of planned behaviour the results show that attitude, subjective norm and perceived control explain between 62% and 67% of driver's variation of intentions to take risks. When descriptive norm was added to the model a small but statistically significant increase was found. The study also shows that more than 35% erroneously believe that their car is equipped with an ESC system. These findings may suggest that driver behaviour could reduce the positive effect ESC has on accidents. It also shows that drivers who purchase a new car are not well informed about what kind of safety devices the car is equipped with. These findings highlight the need for more targeted information to drivers. Copyright © 2010 Elsevier Ltd. All rights reserved.

  7. A 5 Gb/s Radiation Tolerant Laser Driver

    CERN Document Server

    Amaral, L; Da Silva, S; Mazza, G; Meroli, S; Moreira, P; Rivetti, A; Troska, J; Wyllie, K

    2009-01-01

    A laser driver for data transmission at 5 Gb/s has been developed as a part of the Giga Bit Transceiver (GBT) project. The Giga Bit Laser Driver (GBLD) targets High Energy Physics (HEP) applications for which radiation tolerance is mandatory. The GBLD ASIC can drive both VCSELs and some types of edge emitting lasers. It is essentially composed of two drivers capable of sinking up to 12 mA each from the load at a maximum data rate of 5 Gb/s, and of a current sink for the laser bias current. The laser driver include also pre-emphasis and duty cycle control capabilities.

  8. Systems analysis for modular versus multi-beam HIF drivers

    International Nuclear Information System (INIS)

    Meier, W.R.; Logan, B.G.

    2004-01-01

    Previous modeling for HIF drivers concentrated on designs in which 100 or more beams are grouped in an array and accelerated through a common set of induction cores. The total beam energy required by the target is achieved by the combination of final ion energy, current per beam and number of beams. Economic scaling favors a large number of small (∼1 cm dia.) beams. An alternative architecture has now been investigated, which we refer to as a modular driver. In this case, the driver is subdivided into many (>10) independent accelerators with one or many beams each. A key objective of the modular driver approach is to be able to demonstrate all aspects of the driver (source-to-target) by building a single, lower cost module compared to a full-scale, multi-beam driver. We consider and compare several design options for the modular driver including single-beam designs with solenoid instead of quadrupole magnets in order to transport the required current per module in a single beam, solenoid/quad combinations, and multi-beam, all-quad designs. The drivers are designed to meet the requirements of the hybrid target, which can accommodate a larger spot size than the distributed radiator target that was used for the Robust Point Design. We compare the multi-beam and modular driver configuration for a variety and assumptions and identify key technology advances needed for the modular design

  9. Improving drivers' knowledge of road rules using digital games.

    Science.gov (United States)

    Li, Qing; Tay, Richard

    2014-04-01

    Although a proficient knowledge of the road rules is important to safe driving, many drivers do not retain the knowledge acquired after they have obtained their licenses. Hence, more innovative and appealing methods are needed to improve drivers' knowledge of the road rules. This study examines the effect of game based learning on drivers' knowledge acquisition and retention. We find that playing an entertaining game that is designed to impart knowledge of the road rules not only improves players' knowledge but also helps them retain such knowledge. Hence, learning by gaming appears to be a promising learning approach for driver education. Copyright © 2013 Elsevier Ltd. All rights reserved.

  10. 77 FR 10607 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2012-02-22

    ...-2011-0367] Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor... diabetes mellitus (ITDM) from operating commercial motor vehicles (CMVs) in interstate commerce. The...). [[Page 10608

  11. The licensing and safety of older drivers in Britain.

    Science.gov (United States)

    Mitchell, Christopher G B Kit

    2013-01-01

    Driving licence holding in Britain is increasing for older people, particularly older women. Licence holding by men aged 40-69 has saturated at about 90%, and for women aged 30-59 at about 78%. Drivers begin to surrender licences after age 70. By age 90, 38% of women and 25% of men who held a licence at age 70 have surrendered their licences. The paper shows the numbers of car drivers of different ages killed and injured in accidents since 1975 and the fatality and casualty rates per driver and per mile driven. The safety of older drivers is improving faster than that of younger age groups. The number of car driver fatalities aged 70 and over was highest between 1990 and 2004, and has subsequently reduced by almost 40%. For drivers aged 80 and over, the peak was in 2004 and the number has subsequently reduced by almost 50%. The paper uses demographic projections, forecast licence holding and the trends in fatality rates to project the numbers of fatalities for drivers of different ages in Britain. This shows that fatalities among older drivers aged are likely to continue to reduce. Fatality rates for older road users are increased by the fragility of older persons. This disguises the fact that the accident involvement rate for older drivers does not increase with age until after age 75 or 80. Copyright © 2012. Published by Elsevier Ltd.

  12. Testing a structural model of young driver willingness to uptake Smartphone Driver Support Systems.

    Science.gov (United States)

    Kervick, Aoife A; Hogan, Michael J; O'Hora, Denis; Sarma, Kiran M

    2015-10-01

    There is growing interest in the potential value of using phone applications that can monitor driver behaviour (Smartphone Driver Support Systems, 'SDSSs') in mitigating risky driving by young people. However, their value in this regard will only be realised if young people are willing to use this technology. This paper reports the findings of a study in which a novel structural model of willingness to use SDSSs was tested. Grounded in the driver monitoring and Technology Acceptance (TA) research literature, the model incorporates the perceived risks and gains associated with potential SDSS usage and additional social cognitive factors, including perceived usability and social influences. A total of 333 smartphone users, aged 18-24, with full Irish driving licenses completed an online questionnaire examining willingness or Behavioural Intention (BI) to uptake a SDSS. Following exploratory and confirmatory factor analyses, structural equation modelling indicated that perceived gains and social influence factors had significant direct effects on BI. Perceived risks and social influence also had significant indirect effects on BI, as mediated by perceived gains. Overall, this model accounted for 72.5% of the variance in willingness to uptake SDSSs. Multi-group structural models highlighted invariance of effects across gender, high and low risk drivers, and those likely or unlikely to adopt novel phone app technologies. These findings have implications for our understanding of the willingness of young drivers to adopt and use SDSSs, and highlight potential factors that could be targeted in behavioural change interventions seeking to improve usage rates. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Data and methods for studying commercial motor vehicle driver fatigue, highway safety and long-term driver health.

    Science.gov (United States)

    Stern, Hal S; Blower, Daniel; Cohen, Michael L; Czeisler, Charles A; Dinges, David F; Greenhouse, Joel B; Guo, Feng; Hanowski, Richard J; Hartenbaum, Natalie P; Krueger, Gerald P; Mallis, Melissa M; Pain, Richard F; Rizzo, Matthew; Sinha, Esha; Small, Dylan S; Stuart, Elizabeth A; Wegman, David H

    2018-03-09

    This article summarizes the recommendations on data and methodology issues for studying commercial motor vehicle driver fatigue of a National Academies of Sciences, Engineering, and Medicine study. A framework is provided that identifies the various factors affecting driver fatigue and relating driver fatigue to crash risk and long-term driver health. The relevant factors include characteristics of the driver, vehicle, carrier and environment. Limitations of existing data are considered and potential sources of additional data described. Statistical methods that can be used to improve understanding of the relevant relationships from observational data are also described. The recommendations for enhanced data collection and the use of modern statistical methods for causal inference have the potential to enhance our understanding of the relationship of fatigue to highway safety and to long-term driver health. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

  14. Driver fatigue through nightshifts in succession

    Energy Technology Data Exchange (ETDEWEB)

    Mabbott, N.; Lloyd, B. [ARRB Group Ltd., Leederville, WA (United States)

    2005-07-01

    Coal Services (Health and Safety Trust) funded ARRB Transport Research Ltd. to investigate fatigue and performance of truck drivers over consecutive shifts. The main questions were to assess: What is the most important contributor to acute fatigue in mining? Is it length of shift or is it time of day? What is the limit of successive day or night shifts before chronic fatigue affects operator performance in open cut mines? The project methodology included utilising ARRB Fatigue Monitoring Devices in eight haul trucks, testing 24 subjects over several weeks. Each subject filled in a Fatigue Risk Questionnaire on lifestyle and health. Operators worked a 14 night, 1 day off, 13 day roster of 12-hour shifts in a fly-in, fly-out operation with excellent opportunities for restorative sleep between shifts. A total of 3,500 hours of real-time data was collected, representing the first set of objective, real-time driver performance data for Australian mining. The major finding within this study is the combined influence of circadian rhythms and individual variability on performance. The lifestyle habits and the health of individuals have a profound effect on operator performance as shown by the strong positive correlation between high fatigue risk scores from the Fatigue Risk Questionnaire and poor performance. An individualistic approach would appear to have the best chance of reducing high potential incidents due to fatigue through successive nightshifts. 9 refs., 14 figs.

  15. Cognitive compatibility of motorcyclists and car drivers.

    Science.gov (United States)

    Walker, Guy H; Stanton, Neville A; Salmon, Paul M

    2011-05-01

    Incompatibility between different types of road user is a problem that previous research has shown to be resistant to a range of interventions. Cars and motorcycles are particularly prone to this. Insight is provided in this paper by a naturalistic method using concurrent verbal protocols and an automatic, highly reliable semantic network creation tool. The method shows how the same road situation is interpreted differently by car drivers and motorcyclists in ways congruent with wider accident rates. Analysis of the structure and content of the semantic networks reveals a greater degree of cognitive compatibility on faster roads such as motorways, but evidence of more critical incompatibilities on country roads and junctions. Both of these road types are implicated in helping to activate cognitive schema which in turn generate stereotypical behaviors unfavourable to the anticipation of motorcyclists by car drivers. The results are discussed in terms of practical measures such as road signs which warn of events behind as well as in front, cross-mode training and the concept of route driveability. Copyright © 2010 Elsevier Ltd. All rights reserved.

  16. Induction linac drivers: Prospects for the future

    International Nuclear Information System (INIS)

    Keefe, D.

    1989-01-01

    This review is intended to place in perspective our current view of the parameter ranges for induction linac drivers that lead to attractive scenarios for civilian electrical power plants; there is a surprising degree of choice (a factor of 2 or so in most parameters) before any significant impact on the cost of energy results. The progress and goals of the US heavy-ion fusion accelerator research (HIFAR) program are reviewed. The step between the realization of the HIFAR goals and a full-scale driver is seen to be very large indeed and will require one or more significant intermediate steps which can be justified only by a commitment to advance the HIF method towards a true fusion goal. Historial anomalies in the way that fusion programs for both military and civilian applications are administered will need to be resolved; the absence of any presently perceived energy crisis results in little current sense of urgency to develop vigorous long-term energy solutions. (orig.)

  17. Inertially confined fusion using heavy ion drivers

    International Nuclear Information System (INIS)

    Herrmannsfeldt, W.B.; Bangerter, R.O.; Bock, R.; Hogan, W.J.; Lindl, J.D.

    1991-10-01

    The various technical issues of HIF will be briefly reviewed in this paper. It will be seen that there are numerous areas in common in all the approaches to HIF. In the recent International Symposium on Heavy Ion Inertial Fusion, the attendees met in specialized workshop sessions to consider the needs for research in each area. Each of the workshop groups considered the key questions of this report: (1) Is this an appropriate time for international collaboration in HIF? (2) Which problems are most appropriate for such collaboration? (3) Can the sharing of target design information be set aside until other driver and systems issues are better resolved, by which time it might be supposed that there could be a relaxation of classification of target issues? (4) What form(s) of collaboration are most appropriate, e.g., bilateral or multilateral? (5) Can international collaboration be sensibly attempted without significant increases in funding for HIF? The authors of this report share the conviction that collaboration on a broad scale is mandatory for HIF to have the resources, both financial and personnel, to progress to a demonstration experiment. Ultimately it may be possible for a single driver with the energy, power, focusibility, and pulse shape to satisfy the needs of the international community for target physics research. Such a facility could service multiple experimental chambers with a variety of beam geometries and target concepts

  18. Inertially confined fusion using heavy ion drivers

    Energy Technology Data Exchange (ETDEWEB)

    Herrmannsfeldt, W.B. [Stanford Linear Accelerator Center, Menlo Park, CA (United States); Bangerter, R.O. [Lawrence Berkeley Lab., CA (United States); Bock, R. [Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (Germany); Hogan, W.J.; Lindl, J.D. [Lawrence Livermore National Lab., CA (United States)

    1991-10-01

    The various technical issues of HIF will be briefly reviewed in this paper. It will be seen that there are numerous areas in common in all the approaches to HIF. In the recent International Symposium on Heavy Ion Inertial Fusion, the attendees met in specialized workshop sessions to consider the needs for research in each area. Each of the workshop groups considered the key questions of this report: (1) Is this an appropriate time for international collaboration in HIF? (2) Which problems are most appropriate for such collaboration? (3) Can the sharing of target design information be set aside until other driver and systems issues are better resolved, by which time it might be supposed that there could be a relaxation of classification of target issues? (4) What form(s) of collaboration are most appropriate, e.g., bilateral or multilateral? (5) Can international collaboration be sensibly attempted without significant increases in funding for HIF? The authors of this report share the conviction that collaboration on a broad scale is mandatory for HIF to have the resources, both financial and personnel, to progress to a demonstration experiment. Ultimately it may be possible for a single driver with the energy, power, focusibility, and pulse shape to satisfy the needs of the international community for target physics research. Such a facility could service multiple experimental chambers with a variety of beam geometries and target concepts.

  19. Inertially confined fusion using heavy ion drivers

    Energy Technology Data Exchange (ETDEWEB)

    Herrmannsfeldt, W.B. (Stanford Linear Accelerator Center, Menlo Park, CA (United States)); Bangerter, R.O. (Lawrence Berkeley Lab., CA (United States)); Bock, R. (Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (Germany)); Hogan, W.J.; Lindl, J.D. (Lawrence Livermore National Lab., CA (United States))

    1991-10-01

    The various technical issues of HIF will be briefly reviewed in this paper. It will be seen that there are numerous areas in common in all the approaches to HIF. In the recent International Symposium on Heavy Ion Inertial Fusion, the attendees met in specialized workshop sessions to consider the needs for research in each area. Each of the workshop groups considered the key questions of this report: (1) Is this an appropriate time for international collaboration in HIF (2) Which problems are most appropriate for such collaboration (3) Can the sharing of target design information be set aside until other driver and systems issues are better resolved, by which time it might be supposed that there could be a relaxation of classification of target issues (4) What form(s) of collaboration are most appropriate, e.g., bilateral or multilateral (5) Can international collaboration be sensibly attempted without significant increases in funding for HIF The authors of this report share the conviction that collaboration on a broad scale is mandatory for HIF to have the resources, both financial and personnel, to progress to a demonstration experiment. Ultimately it may be possible for a single driver with the energy, power, focusibility, and pulse shape to satisfy the needs of the international community for target physics research. Such a facility could service multiple experimental chambers with a variety of beam geometries and target concepts.

  20. Experiments and prospects for induction linac drivers

    International Nuclear Information System (INIS)

    Keefe, D.

    1986-05-01

    In the last three years, the US program in Heavy Ion Fusion has concentrated on understanding the induction linac approach to a power-plant driver. In this method it is important that the beam current be maximized throughout the accelerator. Consequently, it is crucial to understand the space-charge limit in the AG transport system in the linac and, also, to achieve current amplification during acceleration to keep pace with the kinematical increase of this limit with energy. Experimental results on both these matters and also on the use of multiple beams (inside the same accelerating structure) will be described. A new examination of the most attractive properties of the induction linac for a fusion driver has clearly pointed to the advantage of using heavy ions with a charge-state greater than unity - perhaps q = 3 may be an optimum. This development places even greater importance on understanding space-charge limits and mechanisms for emittance growth; also, it will require a new emphasis on the development of a suitable ion source

  1. Convenience food products. Drivers for consumption.

    Science.gov (United States)

    Brunner, Thomas A; van der Horst, Klazine; Siegrist, Michael

    2010-12-01

    Convenience is one of the big trends in the food business. The demand for convenience food products is steadily increasing; therefore, understanding convenience food consumption is an important issue. Despite being vital properties of convenience food, saving time and effort have not been very successful constructs for predicting convenience food consumption. To examine a wide range of possible drivers for convenience food consumption, the present study uses a convenience food frequency questionnaire that asks about consumption behavior. A paper-and-pencil questionnaire was sent out to a representative sample of people in German-speaking Switzerland and yielded N = 918 complete datasets from persons mainly responsible for buying and preparing food in the household. The various convenience food products could be categorized into four groups, which we labeled as highly processed food items, moderately processed food items, single components, and salads. Fifteen drivers were found to have a significant impact either on total convenience consumption or on one of the identified categories. Strong predictors were age, concern about naturalness, nutrition knowledge, and cooking skills. Copyright © 2010 Elsevier Ltd. All rights reserved.

  2. Induction linac drivers: Prospects for the future

    International Nuclear Information System (INIS)

    Keefe, D.

    1988-06-01

    This review is intended to place in perspective our current view of the parameter ranges for induction linac drivers that lead to attractive scenarios for civilian electrical power plants; there is a surprising degree of choice (a factor of two or so in most parameters) before any significant impact on the cost of energy results. The progress and goals of the US Heavy Ion Accelerator Research (HIFAR) program are reviewed. The step between the realization of the HIFAR goals and a full-scale driver is seen to be very large indeed and will require one or more significant intermediate steps which can be justified only by a commitment to advance the HIF method towards a true fusion goal. Historical anomalies in the way that fusion programs for both military and civilian applications are administered will need to be resolved; the absence of any presently perceived energy crisis results in little current sense of urgency to develop vigorous long-term energy solutions. 12 refs., 3 figs., 1 tab

  3. Emergence of multiple ocean ecosystem drivers in a large ensemble suite with an Earth system model

    Science.gov (United States)

    Rodgers, K. B.; Lin, J.; Frölicher, T. L.

    2015-06-01

    Marine ecosystems are increasingly stressed by human-induced changes. Marine ecosystem drivers that contribute to stressing ecosystems - including warming, acidification, deoxygenation and perturbations to biological productivity - can co-occur in space and time, but detecting their trends is complicated by the presence of noise associated with natural variability in the climate system. Here we use large initial-condition ensemble simulations with an Earth system model under a historical/RCP8.5 (representative concentration pathway 8.5) scenario over 1950-2100 to consider emergence characteristics for the four individual and combined drivers. Using a 1-standard-deviation (67% confidence) threshold of signal to noise to define emergence with a 30-year trend window, we show that ocean acidification emerges much earlier than other drivers, namely during the 20th century over most of the global ocean. For biological productivity, the anthropogenic signal does not emerge from the noise over most of the global ocean before the end of the 21st century. The early emergence pattern for sea surface temperature in low latitudes is reversed from that of subsurface oxygen inventories, where emergence occurs earlier in the Southern Ocean. For the combined multiple-driver field, 41% of the global ocean exhibits emergence for the 2005-2014 period, and 63% for the 2075-2084 period. The combined multiple-driver field reveals emergence patterns by the end of this century that are relatively high over much of the Southern Ocean, North Pacific, and Atlantic, but relatively low over the tropics and the South Pacific. For the case of two drivers, the tropics including habitats of coral reefs emerges earliest, with this driven by the joint effects of acidification and warming. It is precisely in the regions with pronounced emergence characteristics where marine ecosystems may be expected to be pushed outside of their comfort zone determined by the degree of natural background variability

  4. Comparison of older and younger novice driver crash rates: Informing the need for extended Graduated Driver Licensing restrictions.

    Science.gov (United States)

    Curry, Allison E; Metzger, Kristina B; Williams, Allan F; Tefft, Brian C

    2017-11-01

    Few previous studies have directly compared crash rates of older and younger novice drivers. To inform discussion about whether Graduated Driver Licensing (GDL) policies that are applied in the US for younger novice drivers should be applied to older novice drivers, we conducted a longitudinal study to examine overall, nighttime, and multiple passenger crash rates over the initial four years of licensure differ for novice drivers licensed at different ages. Using data from the New Jersey Traffic Safety Outcomes (NJ-TSO) data warehouse, we selected all NJ drivers who obtained their initial intermediate driver's license from 2006 through 2014 and had at least one month of follow-up from the date of licensure to study end or death (n=1,034,835). Novice drivers were grouped based on age at licensure: age 17; 18-20; 21-24; and 25 or older. We estimated monthly rates for overall crashes (per 10,000 licensed drivers) as well as: late night crashes (11:01 p.m.-4:59 a.m.); early night crashes (9:00 p.m.-11:00 p.m.); and multiple passenger crashes (two or more passengers). Average monthly rates were calculated for specific relevant time periods and Poisson regression models were used to compare rates: (1) between novice driver groups with the same time since licensure; (2) over the first 48 months of licensure within each novice driver group; and (3) between same-aged 21-year-old drivers with varying lengths of licensure. Although initial (three months post-licensure) overall crash rates of novice NJ drivers age 21 and older were higher than rates of same-aged experienced drivers, they were substantially lower than initial rates for 17- to 20-year-old novice drivers, who are licensed under GDL policies. Moreover, older novice drivers experience much less steep crash reductions over the first year of licensure than younger novice drivers. Nighttime crash rates among the 21- to 24-year old and aged 25 and older novice driver groups were stable over the first year of licensure

  5. How Drivers Respond to Alarms Adapted to Their Braking Behaviour?

    Science.gov (United States)

    Abe, Genya; Itoh, Makoto

    Determining appropriate alarm timing for Forward Collision Warning Systems (FCWS) may play an important role in enhancing system acceptance by drivers. It is not always true that a common alarm trigger logic is suitable for all drivers, because presented alarms may be differently viewed for each driver, i.e., paying attention or requiring appropriate actions. The current study focused on adaptive alarm timing which was adjusted in response to braking behaviour for collision avoidance for the individual. In Experiment I, the braking performance of individual driver was measured repeatedly to assess the variation of each performance. We utilised the following two indices: elapsed time from the deceleration of the lead car to release of the accelerator (accelerator release time) and elapsed time to application of the brakes (braking response time). Two alarm timings were then determined based on these two indices: (i) the median of the accelerator release time of the driver and (ii) the median of the braking response time of the driver. Experiment II compared the two alarm timings for each driver in order to investigate which timing is more appropriate for enhancing driver trust in the driver-adaptive FCWS and the system effectiveness. The results showed that the timing of the accelerator release time increased the trust ratings more than the timing of braking response. The timing of the braking response time induced a longer response time to application of the brakes. Moreover, the degree to which the response time was longer depended on alarm timing preference of the driver. The possible benefit and drawback of driver-adaptive alarm timing are discussed.

  6. Truck Drivers' Use of the Internet: A Mobile Health Lifeline.

    Science.gov (United States)

    Heaton, Karen; Combs, Bryan; Griffin, Russell

    2017-06-01

    Because of their social isolation, irregular and unpredictable schedules, limited access to health care, and long periods of travel, long-haul truckers may benefit from the use of mobile health applications on Internet-capable devices. The purpose of this study was to determine Internet access and usage among a sample of long-haul truck drivers. In this cross-sectional study, truck drivers completed a pencil and paper survey with questions on demographics, work and health histories, and Internet access and usage for both personal and job reasons. A total of 106 truck drivers were recruited from trucking industry trade shows, by word of mouth, and directly from trucking companies. Overall, the truck drivers' use of the Internet was limited. Their usage for personal and job-related reasons differed. Social connectivity and access to health and wellness information were important during personal usage time. Job-related Internet use was highly practical, and applied to seeking information for directions and maps, fuel stops and pricing, and communicating with employers or transmitting documents. Age and experience were associated with Internet use. Younger, less-experienced drivers used the Internet more than older, experienced drivers. Targeted mobile health messaging may be a useful tool to inform truck drivers of health conditions and plans, and may provide links to primary care providers needing to monitor or notify drivers of diagnostic results or treatment plans.

  7. Functionally Assessing Candidate Drivers Advances Precision Cancer Medicine.

    Science.gov (United States)

    Scott, Kenneth L; Powers, Scott

    2016-08-08

    The complexity of genomic alterations in cancer has made it difficult to identify oncogenic drivers for the development of targeted therapies. The study by Berger et al. in this issue of Cancer Cell demonstrates that high-throughput functional profiling can uncover impactful mutations and oncogenic driver alleles. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. Drivers of Sales Innovation in Business-To-Business Firms

    DEFF Research Database (Denmark)

    Ritter, Thomas; Geersbro, Jens

    2014-01-01

    This paper defines the term sales innovation, offers an operationalization of the concept, and discusses antecedents of sales innovation in terms of important internal and external drivers. An empirical analysis of 409 B2B firms identifies the internal drivers of sales innovation as increased top...

  9. Comprehensive Characterization of Cancer Driver Genes and Mutations

    NARCIS (Netherlands)

    Bailey, Matthew H.; Tokheim, Collin; Porta-Pardo, Eduard; Sengupta, Sohini; Bertrand, Denis; Weerasinghe, Amila; Colaprico, Antonio; Wendl, Michael C.; Kim, Jaegil; Reardon, Brendan; Ng, Patrick Kwok Shing; Jeong, Kang Jin; Cao, Song; Wang, Zixing; Gao, Jianjiong; Gao, Qingsong; Wang, Fang; Liu, Eric Minwei; Mularoni, Loris; Rubio-Perez, Carlota; Nagarajan, Niranjan; Cortés-Ciriano, Isidro; Zhou, Daniel Cui; Liang, Wen Wei; Hess, Julian M.; Yellapantula, Venkata D.; Tamborero, David; Gonzalez-Perez, Abel; Suphavilai, Chayaporn; Ko, Jia Yu; Khurana, Ekta; Park, Peter J.; Van Allen, Eliezer M.; Liang, Han; Caesar-Johnson, Samantha J.; Demchok, John A.; Felau, Ina; Kasapi, Melpomeni; Ferguson, Martin L.; Hutter, Carolyn M.; Sofia, Heidi J.; Tarnuzzer, Roy; Wang, Zhining; Yang, Liming; Zenklusen, Jean C.; Zhang, Jiashan (Julia); Chudamani, Sudha; Liu, Jia; Lolla, Laxmi; Naresh, Rashi; Pihl, Todd; Sun, Qiang; Wan, Yunhu; Wu, Ye; Cho, Juok; DeFreitas, Timothy; Frazer, Scott; Gehlenborg, Nils; Getz, Gad; Heiman, David I.; Kim, Jaegil; Lawrence, Michael S.; Lin, Pei; Meier, Sam; Noble, Michael S.; Saksena, Gordon; Voet, Doug; Zhang, Hailei; Bernard, Brady; Chambwe, Nyasha; Dhankani, Varsha; Knijnenburg, Theo; Kramer, Roger; Leinonen, Kalle; Liu, Yuexin; Miller, Michael; Reynolds, Sheila; Shmulevich, Ilya; Thorsson, Vesteinn; Zhang, Wei; Akbani, Rehan; Broom, Bradley M.; Hegde, Apurva M.; Ju, Zhenlin; Kanchi, Rupa S.; Korkut, Anil; Li, Jun; Liang, Han; Ling, Shiyun; Liu, Wenbin; Lu, Yiling; Mills, Gordon B.; Ng, Kwok Shing; Rao, Arvind; Ryan, Michael; Wang, Jing; Weinstein, John N.; Zhang, Jiexin; Abeshouse, Adam; Armenia, Joshua; Chakravarty, Debyani; Chatila, Walid K.; de Bruijn, Ino; Gao, Jianjiong; Gross, Benjamin E.; Heins, Zachary J.; Kundra, Ritika; La, Konnor; Ladanyi, Marc; Luna, Augustin; Nissan, Moriah G.; Ochoa, Angelica; Phillips, Sarah M.; Reznik, Ed; Sanchez-Vega, Francisco; Sander, Chris; Schultz, Nikolaus; Sheridan, Robert; Sumer, S. Onur; Sun, Yichao; Taylor, Barry S.; Wang, Jioajiao; Zhang, Hongxin; Anur, Pavana; Peto, Myron; Spellman, Paul; Benz, Christopher; Stuart, Joshua M.; Wong, Christopher K.; Yau, Christina; Hayes, D. Neil; Parker, Joel S.; Wilkerson, Matthew D.; Ally, Adrian; Balasundaram, Miruna; Bowlby, Reanne; Brooks, Denise; Carlsen, Rebecca; Chuah, Eric; Dhalla, Noreen; Holt, Robert; Jones, Steven J.M.; Kasaian, Katayoon; Lee, Darlene; Ma, Yussanne; Marra, Marco A.; Mayo, Michael; Moore, Richard A.; Mungall, Andrew J.; Mungall, Karen; Robertson, A. Gordon; Sadeghi, Sara; Schein, Jacqueline E.; Sipahimalani, Payal; Tam, Angela; Thiessen, Nina; Tse, Kane; Wong, Tina; Berger, Ashton C.; Beroukhim, Rameen; Cherniack, Andrew D.; Cibulskis, Carrie; Gabriel, Stacey B.; Gao, Galen F.; Ha, Gavin; Meyerson, Matthew; Schumacher, Steven E.; Shih, Juliann; Kucherlapati, Melanie H.; Kucherlapati, Raju S.; Baylin, Stephen; Cope, Leslie; Danilova, Ludmila; Bootwalla, Moiz S.; Lai, Phillip H.; Maglinte, Dennis T.; Van Den Berg, David J.; Weisenberger, Daniel J.; Auman, J. Todd; Balu, Saianand; Bodenheimer, Tom; Fan, Cheng; Hoadley, Katherine A.; Hoyle, Alan P.; Jefferys, Stuart R.; Jones, Corbin D.; Meng, Shaowu; Mieczkowski, Piotr A.; Mose, Lisle E.; Perou, Amy H.; Perou, Charles M.; Roach, Jeffrey; Shi, Yan; Simons, Janae V.; Skelly, Tara; Soloway, Matthew G.; Tan, Donghui; Veluvolu, Umadevi; Fan, Huihui; Hinoue, Toshinori; Laird, Peter W.; Shen, Hui; Zhou, Wanding; Bellair, Michelle; Chang, Kyle; Covington, Kyle; Creighton, Chad J.; Dinh, Huyen; Doddapaneni, Harsha Vardhan; Donehower, Lawrence A.; Drummond, Jennifer; Gibbs, Richard A.; Glenn, Robert; Hale, Walker; Han, Yi; Hu, Jianhong; Korchina, Viktoriya; Lee, Sandra; Lewis, Lora; Li, Wei; Liu, Xiuping; Morgan, Margaret; Morton, Donna; Muzny, Donna; Santibanez, Jireh; Sheth, Margi; Shinbrot, Eve; Wang, Linghua; Wang, Min; Wheeler, David; Xi, Liu; Zhao, Fengmei; Hess, Julian; Appelbaum, Elizabeth L.; Bailey, Matthew; Cordes, Matthew G.; Ding, Li; Fronick, Catrina C.; Fulton, Lucinda A.; Fulton, Robert S.; Kandoth, Cyriac; Mardis, Elaine R.; McLellan, Michael D.; Miller, Christopher A.; Schmidt, Heather K.; Wilson, Richard K.; Crain, Daniel; Curley, Erin; Gardner, Johanna; Lau, Kevin; Mallery, David; Morris, Scott; Paulauskis, Joseph; Penny, Robert; Shelton, Candace; Shelton, Troy; Sherman, Mark; Thompson, Eric; Yena, Peggy; Bowen, Jay; Gastier-Foster, Julie M.; Gerken, Mark; Leraas, Kristen M.; Lichtenberg, Tara M.; Ramirez, Nilsa C.; Wise, Lisa; Zmuda, Erik; Corcoran, Niall; Costello, Tony; Hovens, Christopher; Carvalho, Andre L.; de Carvalho, Ana C.; Fregnani, José H.; Longatto-Filho, Adhemar; Reis, Rui M.; Scapulatempo-Neto, Cristovam; Silveira, Henrique C.S.; Vidal, Daniel O.; Burnette, Andrew; Eschbacher, Jennifer; Hermes, Beth; Noss, Ardene; Singh, Rosy; Anderson, Matthew L.; Castro, Patricia D.; Ittmann, Michael; Huntsman, David; Kohl, Bernard; Le, Xuan; Thorp, Richard; Andry, Chris; Duffy, Elizabeth R.; Lyadov, Vladimir; Paklina, Oxana; Setdikova, Galiya; Shabunin, Alexey; Tavobilov, Mikhail; McPherson, Christopher; Warnick, Ronald; Berkowitz, Ross; Cramer, Daniel; Feltmate, Colleen; Horowitz, Neil; Kibel, Adam; Muto, Michael; Raut, Chandrajit P.; Malykh, Andrei; Barnholtz-Sloan, Jill S.; Barrett, Wendi; Devine, Karen; Fulop, Jordonna; Ostrom, Quinn T.; Shimmel, Kristen; Wolinsky, Yingli; Sloan, Andrew E.; De Rose, Agostino; Giuliante, Felice; Goodman, Marc; Karlan, Beth Y.; Hagedorn, Curt H.; Eckman, John; Harr, Jodi; Myers, Jerome; Tucker, Kelinda; Zach, Leigh Anne; Deyarmin, Brenda; Hu, Hai; Kvecher, Leonid; Larson, Caroline; Mural, Richard J.; Somiari, Stella; Vicha, Ales; Zelinka, Tomas; Bennett, Joseph; Iacocca, Mary; Rabeno, Brenda; Swanson, Patricia; Latour, Mathieu; Lacombe, Louis; Têtu, Bernard; Bergeron, Alain; McGraw, Mary; Staugaitis, Susan M.; Chabot, John; Hibshoosh, Hanina; Sepulveda, Antonia; Su, Tao; Wang, Timothy; Potapova, Olga; Voronina, Olga; Desjardins, Laurence; Mariani, Odette; Roman-Roman, Sergio; Sastre, Xavier; Stern, Marc Henri; Cheng, Feixiong; Signoretti, Sabina; Berchuck, Andrew; Bigner, Darell; Lipp, Eric; Marks, Jeffrey; McCall, Shannon; McLendon, Roger; Secord, Angeles; Sharp, Alexis; Behera, Madhusmita; Brat, Daniel J.; Chen, Amy; Delman, Keith; Force, Seth; Khuri, Fadlo; Magliocca, Kelly; Maithel, Shishir; Olson, Jeffrey J.; Owonikoko, Taofeek; Pickens, Alan; Ramalingam, Suresh; Shin, Dong M.; Sica, Gabriel; Van Meir, Erwin G.; Zhang, Hongzheng; Eijckenboom, Wil; Gillis, Ad; Korpershoek, Esther; Looijenga, Leendert; Oosterhuis, Wolter; Stoop, Hans; van Kessel, Kim E.; Zwarthoff, Ellen C.; Calatozzolo, Chiara; Cuppini, Lucia; Cuzzubbo, Stefania; DiMeco, Francesco; Finocchiaro, Gaetano; Mattei, Luca; Perin, Alessandro; Pollo, Bianca; Chen, Chu; Houck, John; Lohavanichbutr, Pawadee; Hartmann, Arndt; Stoehr, Christine; Stoehr, Robert; Taubert, Helge; Wach, Sven; Wullich, Bernd; Kycler, Witold; Murawa, Dawid; Wiznerowicz, Maciej; Chung, Ki; Edenfield, W. Jeffrey; Martin, Julie; Baudin, Eric; Bubley, Glenn; Bueno, Raphael; De Rienzo, Assunta; Richards, William G.; Kalkanis, Steven; Mikkelsen, Tom; Noushmehr, Houtan; Scarpace, Lisa; Girard, Nicolas; Aymerich, Marta; Campo, Elias; Giné, Eva; Guillermo, Armando López; Van Bang, Nguyen; Hanh, Phan Thi; Phu, Bui Duc; Tang, Yufang; Colman, Howard; Evason, Kimberley; Dottino, Peter R.; Martignetti, John A.; Gabra, Hani; Juhl, Hartmut; Akeredolu, Teniola; Stepa, Serghei; Hoon, Dave; Ahn, Keunsoo; Kang, Koo Jeong; Beuschlein, Felix; Breggia, Anne; Birrer, Michael; Bell, Debra; Borad, Mitesh; Bryce, Alan H.; Castle, Erik; Chandan, Vishal; Cheville, John; Copland, John A.; Farnell, Michael; Flotte, Thomas; Giama, Nasra; Ho, Thai; Kendrick, Michael; Kocher, Jean Pierre; Kopp, Karla; Moser, Catherine; Nagorney, David; O'Brien, Daniel; O'Neill, Brian Patrick; Patel, Tushar; Petersen, Gloria; Que, Florencia; Rivera, Michael; Roberts, Lewis; Smallridge, Robert; Smyrk, Thomas; Stanton, Melissa; Thompson, R. Houston; Torbenson, Michael; Yang, Ju Dong; Zhang, Lizhi; Brimo, Fadi; Ajani, Jaffer A.; Gonzalez, Ana Maria Angulo; Behrens, Carmen; Bondaruk, Jolanta; Broaddus, Russell; Czerniak, Bogdan; Esmaeli, Bita; Fujimoto, Junya; Gershenwald, Jeffrey; Guo, Charles; Lazar, Alexander J.; Logothetis, Christopher; Meric-Bernstam, Funda; Moran, Cesar; Ramondetta, Lois; Rice, David; Sood, Anil; Tamboli, Pheroze; Thompson, Timothy; Troncoso, Patricia; Tsao, Anne; Wistuba, Ignacio; Carter, Candace; Haydu, Lauren; Hersey, Peter; Jakrot, Valerie; Kakavand, Hojabr; Kefford, Richard; Lee, Kenneth; Long, Georgina; Mann, Graham; Quinn, Michael; Saw, Robyn; Scolyer, Richard; Shannon, Kerwin; Spillane, Andrew; Stretch, Jonathan; Synott, Maria; Thompson, John; Wilmott, James; Al-Ahmadie, Hikmat; Chan, Timothy A.; Ghossein, Ronald; Gopalan, Anuradha; Levine, Douglas A.; Reuter, Victor; Singer, Samuel; Singh, Bhuvanesh; Tien, Nguyen Viet; Broudy, Thomas; Mirsaidi, Cyrus; Nair, Praveen; Drwiega, Paul; Miller, Judy; Smith, Jennifer; Zaren, Howard; Park, Joong Won; Hung, Nguyen Phi; Kebebew, Electron; Linehan, W. Marston; Metwalli, Adam R.; Pacak, Karel; Pinto, Peter A.; Schiffman, Mark; Schmidt, Laura S.; Vocke, Cathy D.; Wentzensen, Nicolas; Worrell, Robert; Yang, Hannah; Moncrieff, Marc; Goparaju, Chandra; Melamed, Jonathan; Pass, Harvey; Botnariuc, Natalia; Caraman, Irina; Cernat, Mircea; Chemencedji, Inga; Clipca, Adrian; Doruc, Serghei; Gorincioi, Ghenadie; Mura, Sergiu; Pirtac, Maria; Stancul, Irina; Tcaciuc, Diana; Albert, Monique; Alexopoulou, Iakovina; Arnaout, Angel; Bartlett, John; Engel, Jay; Gilbert, Sebastien; Parfitt, Jeremy; Sekhon, Harman; Thomas, George; Rassl, Doris M.; Rintoul, Robert C.; Bifulco, Carlo; Tamakawa, Raina; Urba, Walter; Hayward, Nicholas; Timmers, Henri; Antenucci, Anna; Facciolo, Francesco; Grazi, Gianluca; Marino, Mirella; Merola, Roberta; de Krijger, Ronald; Gimenez-Roqueplo, Anne Paule; Piché, Alain; Chevalier, Simone; McKercher, Ginette; Birsoy, Kivanc; Barnett, Gene; Brewer, Cathy; Farver, Carol; Naska, Theresa; Pennell, Nathan A.; Raymond, Daniel; Schilero, Cathy; Smolenski, Kathy; Williams, Felicia; Morrison, Carl; Borgia, Jeffrey A.; Liptay, Michael J.; Pool, Mark; Seder, Christopher W.; Junker, Kerstin; Omberg, Larsson; Dinkin, Mikhail; Manikhas, George; Alvaro, Domenico; Bragazzi, Maria Consiglia; Cardinale, Vincenzo; Carpino, Guido; Gaudio, Eugenio; Chesla, David; Cottingham, Sandra; Dubina, Michael; Moiseenko, Fedor; Dhanasekaran, Renumathy; Becker, Karl Friedrich; Janssen, Klaus Peter; Slotta-Huspenina, Julia; Abdel-Rahman, Mohamed H.; Aziz, Dina; Bell, Sue; Cebulla, Colleen M.; Davis, Amy; Duell, Rebecca; Elder, J. Bradley; Hilty, Joe; Kumar, Bahavna; Lang, James; Lehman, Norman L.; Mandt, Randy; Nguyen, Phuong; Pilarski, Robert; Rai, Karan; Schoenfield, Lynn; Senecal, Kelly; Wakely, Paul; Hansen, Paul; Lechan, Ronald; Powers, James; Tischler, Arthur; Grizzle, William E.; Sexton, Katherine C.; Kastl, Alison; Henderson, Joel; Porten, Sima; Waldmann, Jens; Fassnacht, Martin; Asa, Sylvia L.; Schadendorf, Dirk; Couce, Marta; Graefen, Markus; Huland, Hartwig; Sauter, Guido; Schlomm, Thorsten; Simon, Ronald; Tennstedt, Pierre; Olabode, Oluwole; Nelson, Mark; Bathe, Oliver; Carroll, Peter R.; Chan, June M.; Disaia, Philip; Glenn, Pat; Kelley, Robin K.; Landen, Charles N.; Phillips, Joanna; Prados, Michael; Simko, Jeffry; Smith-McCune, Karen; VandenBerg, Scott; Roggin, Kevin; Fehrenbach, Ashley; Kendler, Ady; Sifri, Suzanne; Steele, Ruth; Jimeno, Antonio; Carey, Francis; Forgie, Ian; Mannelli, Massimo; Carney, Michael; Hernandez, Brenda; Campos, Benito; Herold-Mende, Christel; Jungk, Christin; Unterberg, Andreas; von Deimling, Andreas; Bossler, Aaron; Galbraith, Joseph; Jacobus, Laura; Knudson, Michael; Knutson, Tina; Ma, Deqin; Milhem, Mohammed; Sigmund, Rita; Godwin, Andrew K.; Madan, Rashna; Rosenthal, Howard G.; Adebamowo, Clement; Adebamowo, Sally N.; Boussioutas, Alex; Beer, David; Giordano, Thomas; Mes-Masson, Anne Marie; Saad, Fred; Bocklage, Therese; Landrum, Lisa; Mannel, Robert; Moore, Kathleen; Moxley, Katherine; Postier, Russel; Walker, Joan; Zuna, Rosemary; Feldman, Michael; Valdivieso, Federico; Dhir, Rajiv; Luketich, James; Pinero, Edna M.Mora; Quintero-Aguilo, Mario; Carlotti, Carlos Gilberto; Dos Santos, Jose Sebastião; Kemp, Rafael; Sankarankuty, Ajith; Tirapelli, Daniela; Catto, James; Agnew, Kathy; Swisher, Elizabeth; Creaney, Jenette; Robinson, Bruce; Shelley, Carl Simon; Godwin, Eryn M.; Kendall, Sara; Shipman, Cassaundra; Bradford, Carol; Carey, Thomas; Haddad, Andrea; Moyer, Jeffey; Peterson, Lisa; Prince, Mark; Rozek, Laura; Wolf, Gregory; Bowman, Rayleen; Fong, Kwun M.; Yang, Ian; Korst, Robert; Rathmell, W. Kimryn; Fantacone-Campbell, J. Leigh; Hooke, Jeffrey A.; Kovatich, Albert J.; Shriver, Craig D.; DiPersio, John; Drake, Bettina; Govindan, Ramaswamy; Heath, Sharon; Ley, Timothy; Van Tine, Brian; Westervelt, Peter; Rubin, Mark A.; Lee, Jung Il; Aredes, Natália D.; Mariamidze, Armaz; Lawrence, Michael S.; Godzik, Adam; Lopez-Bigas, Nuria; Stuart, Josh; Wheeler, David; Getz, Gad; Chen, Ken; Lazar, Alexander J.; Mills, Gordon B.; Karchin, Rachel; Ding, Li

    2018-01-01

    Identifying molecular cancer drivers is critical for precision oncology. Multiple advanced algorithms to identify drivers now exist, but systematic attempts to combine and optimize them on large datasets are few. We report a PanCancer and PanSoftware analysis spanning 9,423 tumor exomes (comprising

  10. China-US-Japan workshop on laser plasma and drivers

    International Nuclear Information System (INIS)

    1994-01-01

    Organized by China Institute of Applied Physics and Computational Mathematics (IMPCM) and other 5 organizations, China-US-Japan Workshop on Laser Plasma and Drivers, LPD'94, was held on October 17-21, 1994 at Fragrant Hill Hotel, Beijing, China. Main topics includes: target and plasma physics, ICF Experiments, ICF drivers, etc.. More than 50 pieces of papers are included in the proceedings

  11. 78 FR 8689 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-02-06

    ... detail the qualifications, experience, and medical condition of each applicant for an exemption from the... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... annual medical certification to the employer for retention in the driver's qualification file and retains...

  12. 77 FR 74733 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-12-17

    ... detail the qualifications, experience, and medical condition of each applicant for an exemption from the... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... medical certification to the employer for retention in the driver's qualification file and retains a copy...

  13. 78 FR 16762 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-03-18

    ... qualifications, experience, and medical condition of each applicant for an exemption from the vision requirements...; FMCSA- 2010-0372; FMCSA-2011-0010] Qualification of Drivers; Exemption Applications; Vision AGENCY... the employer for retention in the driver's qualification file and retains a copy of the certification...

  14. 78 FR 10250 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-02-13

    .... The notices of applications stated in detail the qualifications, experience, and medical condition of... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... certification to the employer for retention in the driver's qualification file and retains a copy of the...

  15. 78 FR 51268 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-08-20

    ... qualifications, experience, and medical condition of each applicant for an exemption from the vision requirements... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... the employer for retention in the driver's qualification file and retains a copy of the certification...

  16. 77 FR 10606 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-02-22

    ... applications. The notices of applications stated in detail the qualifications, experience, and medical...-27897; FMCSA-2009-0291; FMCSA-2009-0321] Qualification of Drivers; Exemption Applications; Vision AGENCY... annual medical certification to the employer for retention in the driver's qualification file and retains...

  17. 78 FR 16761 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-03-18

    ... qualifications, experience, and medical condition of each applicant for an exemption from the vision requirements... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... in the driver's qualification file and retains a copy of the certification on his/her person while...

  18. 77 FR 36338 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-06-18

    ... stated in detail the qualifications, experience, and medical condition of each applicant for an exemption...-2009-0206; FMCSA-2010-0050; FMCSA-2010-0082] Qualification of Drivers; Exemption Applications; Vision... in the driver's qualification file and retains a copy of the certification on his/her person while...

  19. 76 FR 44653 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-07-26

    .... The notices of applications stated in detail the qualifications, experience, and medical condition of... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... medical certification to the employer for retention in the driver's qualification file and retains a copy...

  20. 77 FR 48590 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-08-14

    ... notices of applications. The notices of applications stated in detail the qualifications, experience, and...; FMCSA-2010-0114] Qualification of Drivers; Exemption Applications; Vision AGENCY: Federal Motor Carrier... annual medical certification to the employer for retention in the driver's qualification file and retains...

  1. 75 FR 50799 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-08-17

    .... The Notices of applications stated in detail the qualifications, experience, and medical condition of...-0174] Qualification of Drivers; Exemption Applications; Vision AGENCY: Federal Motor Carrier Safety... medical certification to the employer for retention in the driver's qualification file and retains a copy...

  2. 76 FR 15361 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-03-21

    ... detail the qualifications, experience, and medical condition of each applicant for an exemption from the... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... medical certification to the employer for retention in the driver's qualification file and retains a copy...

  3. 78 FR 30954 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-05-23

    ... detail the qualifications, experience, and medical condition of each applicant for an exemption from the...-26066; 2008- 0231] Qualification of Drivers; Exemption Applications; Vision AGENCY: Federal Motor... certification to the employer for retention in the driver's qualification file and retains a copy of the...

  4. 78 FR 63292 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-10-23

    .... The notices of applications stated in detail the qualifications, experience, and medical condition of... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... in the driver's qualification file and retains a copy of the certification on his/her person while...

  5. 76 FR 44652 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-07-26

    ... detail the qualifications, experience, and medical condition of each applicant for an exemption from the...-27897; FMCSA-2009-0054; FMCSA-2009-0086; FMCSA- 2009-0121] Qualification of Drivers; Exemption... retention in the driver's qualification file and retains a copy of the certification on his/her person while...

  6. 78 FR 65032 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-10-30

    ... detail the qualifications, experience, and medical condition of each applicant for an exemption from the... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... certification to the employer for retention in the driver's qualification file and retains a copy of the...

  7. 75 FR 20881 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-04-21

    ... applications. The Notices of applications stated in detail the qualifications, experience, and medical...-2007-0017; FMCSA-2007-0071] Qualification of Drivers; Exemption Applications; Vision AGENCY: Federal... medical certification to the employer for retention in the driver's qualification file and retains a copy...

  8. 76 FR 53708 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-08-29

    ... qualifications, experience, and medical condition of each applicant for an exemption from the vision requirements...-27897; FMCSA-2009-0154] Qualification of Drivers; Exemption Applications; Vision AGENCY: Federal Motor... in the driver's qualification file and retains a copy of the certification on his/her person while...

  9. 76 FR 49531 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-08-10

    .... The notices of applications stated in detail the qualifications, experience, and medical condition of...-2003-15268; FMCSA- 2007-2733] Qualification of Drivers; Exemption Applications; Vision AGENCY: Federal... in the driver's qualification file and retains a copy of the certification on his/her person while...

  10. 76 FR 78729 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-12-19

    .... The notices of applications stated in detail the qualifications, experience, and medical condition of...-15268; FMCSA- 2003-16241; FMCSA-2005-22194] Qualification of Drivers; Exemption Applications; Vision... in the driver's qualification file and retains a copy of the certification on his/her person while...

  11. 76 FR 79760 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-12-22

    ... of applications stated in detail the qualifications, experience, and medical condition of each... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... certification to the employer for retention in the driver's qualification file and retains a copy of the...

  12. 76 FR 9865 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-02-22

    ... detail the qualifications, experience, and medical condition of each applicant for an exemption from the... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... the employer for retention in the driver's qualification file and retains a copy of the certification...

  13. 77 FR 3554 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-01-24

    .... The notices of applications stated in detail the qualifications, experience, and medical condition of...] Qualification of Drivers; Exemption Applications; Vision AGENCY: Federal Motor Carrier Safety Administration... retention in the driver's qualification file and retains a copy of the certification on his/her person while...

  14. 76 FR 70210 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-11-10

    ... detail the qualifications, experience, and medical condition of each applicant for an exemption from the...-22194; FMCSA- 2007-27897; FMCSA-2007-28695; FMCSA-2009-0206] Qualification of Drivers; Exemption... annual medical certification to the employer for retention in the driver's qualification file and retains...

  15. 75 FR 52063 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-08-24

    ... notices of applications. The notices of applications stated in detail the qualifications, experience, and... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... in the driver's qualification file and retains a copy of the certification on his/her person while...

  16. 76 FR 29026 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-05-19

    ... applications. The notices of applications stated in detail the qualifications, experience, and medical...-14504; FMCSA- 2008-0231; FMCSA-2008-0398] Qualification of Drivers; Exemption Applications; Vision... medical certification to the employer for retention in the driver's qualification file and retains a copy...

  17. 76 FR 12216 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-03-04

    ... detail the qualifications, experience, and medical condition of each applicant for an exemption from the...-12844; FMCSA- 2005-20027; FMCSA-2006-25246] Qualification of Drivers; Exemption Applications; Vision... the employer for retention in the driver's qualification file and retains a copy of the certification...

  18. 76 FR 78728 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-12-19

    ... detail the qualifications, experience, and medical condition of each applicant for an exemption from the... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... in the driver's qualification file and retains a copy of the certification on his/her person while...

  19. 78 FR 57679 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-09-19

    .... The notices of applications stated in detail the qualifications, experience, and medical condition of...; FMCSA- 2006-26653; FMCSA-2007-0071; FMCSA-2008-0398] Qualification of Drivers; Exemption Applications... retention in the driver's qualification file and retains a copy of the certification on his/her person while...

  20. 75 FR 19674 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-04-15

    ... applications. The notices of applications stated in detail the qualifications, experience, and medical...; FMCSA-2005-22727; FMCSA-2007-0017; FMCSA- 2007-0071; FMCSA-2008-0021] Qualification of Drivers... in the driver's qualification file and retain a copy of the certification on his/her person while...

  1. 75 FR 80887 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-12-23

    ... qualifications, experience, and medical condition of each applicant for an exemption from the vision requirements... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... annual medical certification to the employer for retention in the driver's qualification file and retains...

  2. 75 FR 27622 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-05-17

    ... applications. The notices of applications stated in detail the qualifications, experience, and medical...-24015; FMCSA-2007-0071; FMCSA-2008-0021] Qualification of Drivers; Exemption Applications; Vision AGENCY... the employer for retention in the driver's qualification file and retains a copy of the certification...

  3. 76 FR 66123 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-10-25

    .... The notices of applications stated in detail the qualifications, experience, and medical condition of... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... the employer for retention in the driver's qualification file and retains a copy of the certification...

  4. 77 FR 76166 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-12-26

    ... of applications stated in detail the qualifications, experience, and medical condition of each...; FMCSA- 2002-12294; FMCSA-2006-24783 FMCSA-2006-26066] Qualification of Drivers; Exemption Applications... annual medical certification to the employer for retention in the driver's qualification file and retains...

  5. 78 FR 62938 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-10-22

    ... notices of applications. ] The notices of applications stated in detail the qualifications, experience... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... in the driver's qualification file and retains a copy of the certification on his/her person while...

  6. 75 FR 64396 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-10-19

    ... qualifications, experience, and medical condition of each applicant for an exemption from the vision requirements...; FMCSA- 2008-0231; FMCSA-2008-0266] Qualification of Drivers; Exemption Applications; Vision AGENCY... the employer for retention in the driver's qualification file and retains a copy of the certification...

  7. 78 FR 67462 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-11-12

    .... The notices of applications stated in detail the qualifications, experience, and medical condition of... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... in the driver's qualification file and retains a copy of the certification on his/her person while...

  8. 75 FR 38602 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-07-02

    ... qualifications, experience, and medical condition of each applicant for an exemption from the vision requirements...-0021] Qualification of Drivers; Exemption Applications; Vision AGENCY: Federal Motor Carrier Safety... medical certification to the employer for retention in the driver's qualification file and retains a copy...

  9. 77 FR 10604 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-02-22

    ... detail the qualifications, experience, and medical condition of each applicant for an exemption from the...] Qualification of Drivers; Exemption Applications; Vision AGENCY: Federal Motor Carrier Safety Administration... medical certification to the employer for retention in the driver's qualification file and retains a copy...

  10. 77 FR 40946 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-07-11

    ... of applications stated in detail the qualifications, experience, and medical condition of each...-0082] Qualification of Drivers; Exemption Applications; Vision AGENCY: Federal Motor Carrier Safety... the employer for retention in the driver's qualification file and retains a copy of the certification...

  11. 78 FR 32708 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-05-31

    .... The notices of applications stated in detail the qualifications, experience, and medical condition of... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... in the driver's qualification file and retains a copy of the certification on his/her person while...

  12. 78 FR 74223 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-12-10

    ... the qualifications, experience, and medical condition of each applicant for an exemption from the... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... medical certification to the employer for retention in the driver's qualification file and retains a copy...

  13. 78 FR 64280 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-10-28

    ... notices of applications. The notices of applications stated in detail the qualifications, experience, and...; FMCSA- 2003-15892; FMCSA-2005-21711] Qualification of Drivers; Exemption Applications; Vision AGENCY... retention in the driver's qualification file and retains a copy of the certification on his/her person while...

  14. 75 FR 27623 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-05-17

    ... detail the qualifications, experience, and medical condition of each applicant for an exemption from the...; FMCSA- 2000-7165; FMCSA-2000-7363; FMCSA-2004-17195; FMCSA-2006-23773] Qualification of Drivers... medical certification to the employer for retention in the driver's qualification file and retains a copy...

  15. 76 FR 64171 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-10-17

    ... qualifications, experience, and medical condition of each applicant for an exemption from the vision requirements...; FMCSA- 2006-26066; FMCSA-2007-27897; FMCSA-2007-28695; FMCSA-2009-0154] Qualification of Drivers... in the driver's qualification file and retains a copy of the certification on his/her person while...

  16. 76 FR 55467 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-09-07

    ... qualifications, experience, and medical condition of each applicant for an exemption from the vision requirements...-21254; FMCSA-2007-27897] Qualification of Drivers; Exemption Applications; Vision AGENCY: Federal Motor... the employer for retention in the driver's qualification file and retains a copy of the certification...

  17. 75 FR 79079 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-12-17

    ... applications. The notices of applications stated in detail the qualifications, experience, and medical...-12294; FMCSA-2000-7363; FMCSA-2000-7165; FMCSA-2000-8203; FMCSA-1998-3637] Qualification of Drivers... the employer for retention in the driver's qualification file and retains a copy of the certification...

  18. 77 FR 26816 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-05-07

    .... The notices of applications stated in detail the qualifications, experience, and medical condition of...-0021] Qualification of Drivers; Exemption Applications; Vision AGENCY: Federal Motor Carrier Safety... medical certification to the employer for retention in the driver's qualification file and retains a copy...

  19. 78 FR 797 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-01-04

    ... of applications stated in detail the qualifications, experience, and medical condition of each... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... certification to the employer for retention in the driver's qualification file and retains a copy of the...

  20. 77 FR 40945 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-07-11

    ... applications. The notices of applications stated in detail the qualifications, experience, and medical...-24783; FMCSA-2008-0021; FMCSA-2010-0050; FMCSA-2010-0114] Qualification of Drivers; Exemption... annual medical certification to the employer for retention in the driver's qualification file and retains...

  1. 75 FR 8184 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-02-23

    ... notices of applications stated in detail the qualifications, experience, and medical condition of each...-22194; FMCSA-2007-27897] Qualification of Drivers; Exemption Applications; Vision AGENCY: Federal Motor... medical certification to the employer for retention in the driver's qualification file and retain a copy...

  2. 78 FR 26106 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-05-03

    ... stated in detail the qualifications, experience, and medical condition of each applicant for an exemption...-0340; FMCSA-2009-0054; FMCSA-2011-0024] Qualification of Drivers; Exemption Applications; Vision AGENCY... in the driver's qualification file and retains a copy of the certification on his/her person while...

  3. 78 FR 51269 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-08-20

    ... notices of applications. The notices of applications stated in detail the qualifications, experience, and...; FMCSA- 2010-0354; FMCSA-2010-0413] Qualification of Drivers; Exemption Applications; Vision AGENCY... retention in the driver's qualification file and retains a copy of the certification on his/her person while...

  4. 78 FR 57677 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-09-19

    ... applications. The notices of applications stated in detail the qualifications, experience, and medical...; FMCSA- 2005-20027; FMCSA-2005-20560] Qualification of Drivers; Exemption Applications; Vision AGENCY... annual medical certification to the employer for retention in the driver's qualification file and retains...

  5. 76 FR 55469 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2011-09-07

    ... detail the qualifications, experience, and medical condition of each applicant for an exemption from the... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Vision... medical certification to the employer for retention in the driver's qualification file and retains a copy...

  6. Drivers and Interpretations of Doctoral Education Today: National Comparisons

    DEFF Research Database (Denmark)

    Andres, Lesley; Bengtsen, Søren Smedegaard; Castano, Liliana Del Pilar Gallego

    2015-01-01

    In the last decade, doctoral education has undergone a sea change with several global trends increasingly apparent. Drivers of change include massification and professionalization of doctoral education and the introduction of quality assurance systems. The impact of these drivers, and the forms...

  7. 78 FR 22602 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2013-04-16

    ... supported by the applicants' possession of valid commercial driver's licenses (CDLs) or non-CDLs to operate... histories. Camille Myers stated the importance of standardized visual testing for all drivers when licenses... enable these individuals to operate commercial motor vehicles (CMVs) in interstate commerce without...

  8. Older drivers and ADAS : which systems improve road safety?

    NARCIS (Netherlands)

    Davidse, R.J.

    2006-01-01

    In the coming decades, the number of older drivers that experiences difficulties in traffic as a result of functional limitations will strongly increase. Advanced Driver Assistance Systems (ADAS) could resolve some of these difficulties, by providing personal assistance in a road environment that

  9. Highly automated driving, secondary task performance, and driver state.

    Science.gov (United States)

    Merat, Natasha; Jamson, A Hamish; Lai, Frank C H; Carsten, Oliver

    2012-10-01

    A driving simulator study compared the effect of changes in workload on performance in manual and highly automated driving. Changes in driver state were also observed by examining variations in blink patterns. With the addition of a greater number of advanced driver assistance systems in vehicles, the driver's role is likely to alter in the future from an operator in manual driving to a supervisor of highly automated cars. Understanding the implications of such advancements on drivers and road safety is important. A total of 50 participants were recruited for this study and drove the simulator in both manual and highly automated mode. As well as comparing the effect of adjustments in driving-related workload on performance, the effect of a secondary Twenty Questions Task was also investigated. In the absence of the secondary task, drivers' response to critical incidents was similar in manual and highly automated driving conditions. The worst performance was observed when drivers were required to regain control of driving in the automated mode while distracted by the secondary task. Blink frequency patterns were more consistent for manual than automated driving but were generally suppressed during conditions of high workload. Highly automated driving did not have a deleterious effect on driver performance, when attention was not diverted to the distracting secondary task. As the number of systems implemented in cars increases, an understanding of the implications of such automation on drivers' situation awareness, workload, and ability to remain engaged with the driving task is important.

  10. Vehicle handling aspects by drivers with special needs

    NARCIS (Netherlands)

    Hekstra, A.; Kempeneers, R.

    1999-01-01

    The requirements and assessment criteria to determine the medical fitness to drive and the driving skills of the European driver are outlined in the driving licence directive (91/439/EEG). All drivers must comply to these criteria. An expert judgement on compliance is made at least once for each

  11. Discovery of cancer common and specific driver gene sets

    Science.gov (United States)

    2017-01-01

    Abstract Cancer is known as a disease mainly caused by gene alterations. Discovery of mutated driver pathways or gene sets is becoming an important step to understand molecular mechanisms of carcinogenesis. However, systematically investigating commonalities and specificities of driver gene sets among multiple cancer types is still a great challenge, but this investigation will undoubtedly benefit deciphering cancers and will be helpful for personalized therapy and precision medicine in cancer treatment. In this study, we propose two optimization models to de novo discover common driver gene sets among multiple cancer types (ComMDP) and specific driver gene sets of one certain or multiple cancer types to other cancers (SpeMDP), respectively. We first apply ComMDP and SpeMDP to simulated data to validate their efficiency. Then, we further apply these methods to 12 cancer types from The Cancer Genome Atlas (TCGA) and obtain several biologically meaningful driver pathways. As examples, we construct a common cancer pathway model for BRCA and OV, infer a complex driver pathway model for BRCA carcinogenesis based on common driver gene sets of BRCA with eight cancer types, and investigate specific driver pathways of the liquid cancer lymphoblastic acute myeloid leukemia (LAML) versus other solid cancer types. In these processes more candidate cancer genes are also found. PMID:28168295

  12. The effect of one additional driver mutation on tumor progression

    Science.gov (United States)

    Reiter, Johannes G; Bozic, Ivana; Allen, Benjamin; Chatterjee, Krishnendu; Nowak, Martin A

    2013-01-01

    Tumor growth is caused by the acquisition of driver mutations, which enhance the net reproductive rate of cells. Driver mutations may increase cell division, reduce cell death, or allow cells to overcome density-limiting effects. We study the dynamics of tumor growth as one additional driver mutation is acquired. Our models are based on two-type branching processes that terminate in either tumor disappearance or tumor detection. In our first model, both cell types grow exponentially, with a faster rate for cells carrying the additional driver. We find that the additional driver mutation does not affect the survival probability of the lesion, but can substantially reduce the time to reach the detectable size if the lesion is slow growing. In our second model, cells lacking the additional driver cannot exceed a fixed carrying capacity, due to density limitations. In this case, the time to detection depends strongly on this carrying capacity. Our model provides a quantitative framework for studying tumor dynamics during different stages of progression. We observe that early, small lesions need additional drivers, while late stage metastases are only marginally affected by them. These results help to explain why additional driver mutations are typically not detected in fast-growing metastases. PMID:23396615

  13. Risk factors for road traffic accidents among drivers of public ...

    African Journals Online (AJOL)

    This study aimed to determine the prevalence and risk factors for self reported RTA among drivers of educational institutions and make suggestions to promote safer driving. A cross sectional population study of motor vehicle drivers from the College of Medicine, University of Ibadan and University College Hospital (UCH)

  14. [Taxi driver--film portrait of the insomniac].

    Science.gov (United States)

    Skårderud, Finn

    2009-09-10

    Martin Scorsese's film "Taxi Driver" from 1976 is a cinematic masterpiece. The main character cannot sleep. His condition is caused by inner restlessness and external commotion. The film shows us New York City's brutal nightlife through the distorted mind of a taxi driver.

  15. Drug use disorders among long distance commercial vehicle drivers ...

    African Journals Online (AJOL)

    Substance use disorder occur among long distance commercial vehicle drivers, and there is a need to develop a system that identifies substance use disorders and provides treatment for drug users as part of a holistic approach against drugged-driving. Keywords: Drug-use disorders, long-distance commercial drivers, ...

  16. Graduated driver licensing. [previously called: The graduated driving licence.

    NARCIS (Netherlands)

    2006-01-01

    Young novice drivers have a very high risk of being involved in a road crash. In the United States (US), Canada, Australia and New Zealand this problem has been tackled by first letting learner drivers gain driving experience under safe conditions before allowing them to take the driving test. The

  17. Real time PCI display driver based on VxWorks

    International Nuclear Information System (INIS)

    Liu Weiyue; Wang Yanfang; Liu Songqiang

    2002-01-01

    A kind of real time display driver is introduced. The driver is designed for S3 ViRGE/DX on VxWorks. What described mainly are registers of S3 ViRGE/DX, structure of the software, PCI, hardware graphics acceleration and the chip clocks. The design is compatible with UGL

  18. Illinois School Bus Driver Instructional Program. Trainee Guide. Revised.

    Science.gov (United States)

    Illinois State Board of Education, Springfield.

    This trainee guide contains six units of materials for use by those studying to become school bus drivers in the State of Illinois. Covered in the units are the following topics: school bus driver role and responsibility, passenger control, first aid, driving fundamentals, accidents and emergencies, and detecting hazards. Each unit contains a…

  19. 49 CFR 383.51 - Disqualification of drivers.

    Science.gov (United States)

    2010-10-01

    ... parking violation) arising in connection with a fatal accident 60 days 60 days 120 days 120 days. (6... less than 120 days No less than 1 year. (4) The driver fails to have sufficient space to drive... driver fails to negotiate a crossing because of insufficient undercarriage clearance * * * No less than...

  20. Knowledge, Attitude and Practice of Commercial Drivers in Dar es ...

    African Journals Online (AJOL)

    Purpose: The objective of this study was, first, to assess the knowledge, attitude and practice of commercial drivers in Dar es Salaam with regard to medicines that impair driving, and second, to evaluate the adequacy of antihistamine label information. Methods: Drivers were interviewed using a questionnaire after obtaining ...

  1. Priming Drivers before Handover in Semi-Autonomous Cars

    NARCIS (Netherlands)

    van der Heiden, R.M.A.; Iqbal, Shamsi T.; Janssen, C.P.

    2017-01-01

    Semi-autonomous vehicles occasionally require control to be handed over to the driver in situations where the vehicle is unable to operate safely. Currently, such handover requests require the driver to take control almost instantaneously. We investigate how auditory pre-alerts that occur well

  2. Improvements in Symbol Sign Design To Aid Older Drivers

    Science.gov (United States)

    1995-08-01

    Studies have shown that older drivers have higher rates of accidents, injuries, and fatalities on a per-mile-driven basis. A major cause of roadway accidents for older drivers is failure to heed traffic signs. Previous research found that older drive...

  3. Teen driver support system (TDSS) field operational test : final report.

    Science.gov (United States)

    2015-11-01

    Although teen drivers make up a small percentage of the U.S. driving population, they are at an especially high risk : of being involved in a crash. Factors that contribute to teen drivers risk include their lack of experience and their : tendency...

  4. 76 FR 17475 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2011-03-29

    ...-0058] Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier... individuals for exemption from the prohibition against persons with insulin-treated diabetes mellitus (ITDM... must provide for individual assessment of drivers with diabetes mellitus, and be consistent with the...

  5. Kantian Critique as a possible Driver for Planned Change

    DEFF Research Database (Denmark)

    Petersen, Martin Lund; Bordum, Anders

    In this article it is revealed that planned change approaches operate with multiple drivers for change, but often neglect critique as a relevant driver for change. This is in contradistinction to approaches within the social sciences, where critique is often seen as a relevant approach to creatin...

  6. 78 FR 64267 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-10-28

    ...-0184] Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier... against persons with insulin- treated diabetes mellitus (ITDM) operating commercial motor vehicles (CMVs... drivers with diabetes mellitus, and be consistent with the criteria described in section 4018 of the...

  7. 78 FR 50482 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-08-19

    ...-0183] Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier... individuals for exemption from the prohibition against persons with insulin-treated diabetes mellitus (ITDM... revision must provide for individual assessment of drivers with diabetes mellitus, and be consistent with...

  8. 76 FR 72031 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2011-11-21

    ...-0301] Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier... individuals for exemption from the prohibition against persons with insulin-treated diabetes mellitus (ITDM...).\\1\\ The revision must provide for individual assessment of drivers with diabetes mellitus, and be...

  9. 77 FR 59447 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2012-09-27

    ...-0281] Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier... individuals for exemption from the prohibition against persons with insulin-treated diabetes mellitus (ITDM... drivers with diabetes mellitus, and be consistent with the criteria described in section 4018 of the...

  10. 77 FR 3549 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2012-01-24

    ...-0368] Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier... individuals for exemption from the prohibition against persons with insulin-treated diabetes mellitus (ITDM...\\ The revision must provide for individual assessment of drivers with diabetes mellitus, and be...

  11. 78 FR 65034 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-10-30

    ...-0190] Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier... against persons with insulin- treated diabetes mellitus (ITDM) operating commercial motor vehicles (CMVs... drivers with diabetes mellitus, and be consistent with the criteria described in section 4018 of the...

  12. 76 FR 79756 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2011-12-22

    ...-0326] Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier... individuals for exemption from the prohibition against persons with insulin-treated diabetes mellitus (ITDM...).\\1\\ The revision must provide for individual assessment of drivers with diabetes mellitus, and be...

  13. 77 FR 17111 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2012-03-23

    ...-0042] Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier... individuals for exemption from the prohibition against persons with insulin-treated diabetes mellitus (ITDM... revision must provide for individual assessment of drivers with diabetes mellitus, and be consistent with...

  14. 77 FR 18302 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2012-03-27

    ...-0043] Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier... individuals for exemption from the prohibition against persons with insulin-treated diabetes mellitus (ITDM... for individual assessment of drivers with diabetes mellitus, and be consistent with the criteria...

  15. 78 FR 50486 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-08-19

    ...-0182] Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier... individuals for exemption from the prohibition against persons with insulin-treated diabetes mellitus (ITDM... revision must provide for individual assessment of drivers with diabetes mellitus, and be consistent with...

  16. 78 FR 16758 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2013-03-18

    ...-0012] Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier... individuals for exemption from the prohibition against persons with insulin-treated diabetes mellitus (ITDM... individual assessment of drivers with diabetes mellitus, and be consistent with the criteria described in...

  17. 77 FR 48587 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2012-08-14

    ...-0217] Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier... individuals for exemption from the prohibition against persons with insulin-treated diabetes mellitus (ITDM... drivers with diabetes mellitus, and be consistent with the criteria described in section 4018 of the...

  18. Design and validation of advanced driver assistance systems

    NARCIS (Netherlands)

    Gietelink, O.J.

    2007-01-01

    This thesis presents new tools and methods for the design and validation of advanced driver assistance systems (ADASs). ADASs aim to improve driving comfort and traffic safety by assisting the driver in recognizing and reacting to potentially dangerous traffic situations. A major challenge in

  19. 75 FR 38597 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2010-07-02

    ... and willingness of the driver to monitor blood glucose level on an ongoing basis. Until the Agency... they include the following: (1) That each individual submit a quarterly monitoring checklist completed... qualification file, or keep a copy in his/her driver's qualification file if he/she is self- employed. The...

  20. 76 FR 78718 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2011-12-19

    ... diabetic condition, including the individual ability and willingness of the driver to monitor blood glucose... they include the following: (1) That each individual submit a quarterly monitoring checklist completed... qualification file, or keep a copy in his/her driver's qualification file if he/she is self- employed. The...

  1. Influencing Driver Behavior on Nigerian Roads | Ogwude | Journal ...

    African Journals Online (AJOL)

    This paper argues that influencing driver behavior is a major strategy for improving safe road usage in Nigeria. It uses the findings of a recent study conducted by the author to show the facets of driver behavior which contribute to incidence of road crashes and should therefore be controlled. As these factors derive from the ...

  2. Driver Aid and Education Test Project. Final Report.

    Science.gov (United States)

    Shadis, W.; Soucek, S. J.

    A driver education project tested the hypothesis that measurable improvements in fleet fuel economy can be achieved by driver awareness training in fuel-efficient driving techniques and by a manifold vacuum gauge, used individually or in combination with each other. From April 1976 through December 1977 data were collected in the Las Vegas,…

  3. TRENDS AND ISSUES IN SAFE DRIVER ASSISTANCE SYSTEMS

    Directory of Open Access Journals (Sweden)

    Sadayuki TSUGAWA

    2006-01-01

    Full Text Available In recent years, ITS projects in Japan, Europe and the US have been characterized by a strong emphasis on safe driver assistance systems designed to prevent traffic accidents. As it has become clear that eradicating accidents will be impossible by means of vehicle passive safety and single-vehicle active safety efforts alone, research and development of systems for preventing accidents through road-vehicle cooperation and vehicle-vehicle cooperation have been promoted in Japan (ASV, AHS, Europe (PReVENT, SAFESPOT and the US (VII. The key to such technology is road-to-vehicle communications and inter-vehicle communications. On the other hand, a number of driver assistance systems have been brought to market, including lidar-based forward collision warnings, ACC, lane keeping support and drowsiness warnings, but their penetration rates in Japan are extremely low. Furthermore, one major challenge is that safe driver assistance systems based on road-vehicle and vehicle-vehicle cooperation are premised upon a high penetration rate. Finally, we introduce a system for improving driver acceptance of safe driver assistance systems based on driver monitoring and forward monitoring as well as cooperative driver assistance systems for elderly drivers, an issue now receiving attention in Japan.

  4. The definition of and drivers of new product performance

    DEFF Research Database (Denmark)

    Jespersen, Kristina Risom; Juhl, Hans Jørn

    In the last three decades academic research on new product development has tried to identify the drivers of new product development performance. This body of research is characterised by a vast amount of different definitions of both the drivers of new product performance and the performance...

  5. School Bus Drivers Can Give Your Special Kids Special Help.

    Science.gov (United States)

    Land, Imogene

    1984-01-01

    The state of Oklahoma recently published a school bus driver manual on transporting handicapped students. Yearly inservice training sessions are recommended to teach school bus drivers communication skills, use of special equipment for physically handicapped students, and preparation for emergencies. (MLF)

  6. 76 FR 5324 - Hours of Service of Drivers

    Science.gov (United States)

    2011-01-31

    ... material to the FMCSA staff at the session for inclusion in the public docket, FMCSA- 2004-19608. The... driver goes beyond the 10th hour. 1a. For example, on days in which the driver both picks up and delivers...

  7. Drinking driver and traffic safety project. Volume 1

    Science.gov (United States)

    1972-05-01

    This is the final report of a four-year study of drinking drivers. On the basis of analyses of over 4,000 cases (approximately 1400 of whom were driver's license applicants who had no convictions for drunk-driving, and the remainder had been convicte...

  8. Defensive Tips in the War against Drunk Drivers.

    Science.gov (United States)

    Penkivich, Robert R.

    The purpose of this book, written by a retired law enforcement officer, is to educate the public about drunk drivers, drinking drivers, and high-speed driving, in an effort to prevent injury, death, and suffering. It is intended to be an instructional manual and a practical, common-sense survival guide for the average individual. National…

  9. Taxi 'sugar daddies' and taxi queens: Male taxi driver attitudes ...

    African Journals Online (AJOL)

    Media reports are emerging on the phenomenon of young girls who travel with older mini-bus taxi drivers, and who are thought to have sex with the drivers in exchange for gifts and money. The extent to which such relationships might facilitate unsafe sexual practices and increased risks for both the men and the young ...

  10. Improved power quality based high brightness LED lamp driver ...

    African Journals Online (AJOL)

    This paper deals with a power factor corrected (PFC) improved power quality based LED lamp driver. The proposed driver consists of a PFC Cuk DC-DC converter which operates in continuous conduction mode (CCM) to improve the power quality at input AC mains. The design, modeling and simulation of an 18W LED (six ...

  11. The role of simulation in the assessment of older drivers.

    NARCIS (Netherlands)

    Sommer, Sascha; Rothermel, Stefan; Henriksson, Per; de Waard, Dick; Brookhuis, Karel; Sommer, Sascha; Verwey, Willem B.

    2003-01-01

    Within the project AGILE an assessment system for ageing drivers is developed. A multi-tier procedure including simulator-based diagnostic tests is will be created. Objective driver performance measurement, design of risky scenarios to test performance limits and high face validity are benefits of

  12. Driver Compliance with Traffic Signal Indications in Two Ghanaian ...

    African Journals Online (AJOL)

    Driver response to signal indications was monitored at a selected number of signalised intersections and signal-controlled pedestrian crossings within the Kumasi and Accra metropolitan areas. The objective of the study was to establish the scale of red-light running among drivers in the two cities. Out of 189,628 vehicle ...

  13. Study of human interface for narrow road drive assist system considered characteristic of driver; Driver no tokusei wo koryoshita kyoro soko shien system no human interface no kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    Ikeda, A. [Subaru Research Center Co., Tokyo (Japan); Amada, N.; Kawashima, H. [Keio University, Tokyo (Japan)

    1997-10-01

    The measurement of driver`s watching point, driving time on narrow road and the evaluation of stress etc. were conducted in order to construct the narrow road drive assist system using the stereo image recognition system. Consequently, the driver`s thinking process, stress factor and the indispensable information for this system were clarified. 4 refs., 8 figs., 3 tabs.

  14. The drivers of the nuclear renaissance

    International Nuclear Information System (INIS)

    Dias, Marcio Soares; Mattos, Joao Roberto Loureiro de

    2008-01-01

    The renaissance of the nuclear option for generating electric energy is stimulated by its economic competitiveness and its social and environmental benefits. Presently, nuclear energy is a key component to the rapid expansion of world electricity consumption. Drivers of the nuclear renaissance are: the growth of public acceptance as result of the historic demonstration of safety; the economic competitiveness in the costs of generation; the incorporation of innovations and technological advances with impacts on main barriers like the reducing of the capital investments and technological solutions for destination of the radioactive wastes. The nuclear retaken already affects the international Uranium market with records of negotiated volumes and a rise of prices. Brazil as detainer of some of the biggest reserves of Uranium in the world has much to profit with this retaken. (author)

  15. Laser drivers for inertial confinement fusion

    International Nuclear Information System (INIS)

    Holzrichter, J.F.

    1983-01-01

    Inertial Confinement Fusion (ICF) is the technology that we are developing to access the vast stored energy potential of deuterium fuel located in the world's water supply. This form of fusion is accomplished by compressing and heating small volumes of D-T fuel to very high temperatures (greater than 100M 0 C) and to very high densities (greater than 1000 times the normal liquid density). Under these fuel conditions, a thermonuclear reaction can occur, leading to a net energy release compared to the energy used to heat the fuel initially. To accomplish the condition where fusion reactions begin, effective drivers are required. These are lasers or particle beam accelerators which can provide greater than 10 14 W/cm 2 over millimeter scale targets with an appropriately programmed intensity vs time. At present, we are using research lasers to obtain an understanding of the physics and engineering of fuel compression

  16. FRIB driver linac vacuum model and benchmarks

    CERN Document Server

    Durickovic, Bojan; Kersevan, Roberto; Machicoane, Guillaume

    2014-01-01

    The Facility for Rare Isotope Beams (FRIB) is a superconducting heavy-ion linear accelerator that is to produce rare isotopes far from stability for low energy nuclear science. In order to achieve this, its driver linac needs to achieve a very high beam current (up to 400 kW beam power), and this requirement makes vacuum levels of critical importance. Vacuum calculations have been carried out to verify that the vacuum system design meets the requirements. The modeling procedure was benchmarked by comparing models of an existing facility against measurements. In this paper, we present an overview of the methods used for FRIB vacuum calculations and simulation results for some interesting sections of the accelerator. (C) 2013 Elsevier Ltd. All rights reserved.

  17. The CMS Tracker Readout Front End Driver

    CERN Document Server

    Foudas, C.; Ballard, D.; Church, I.; Corrin, E.; Coughlan, J.A.; Day, C.P.; Freeman, E.J.; Fulcher, J.; Gannon, W.J.F.; Hall, G.; Halsall, R.N.J.; Iles, G.; Jones, J.; Leaver, J.; Noy, M.; Pearson, M.; Raymond, M.; Reid, I.; Rogers, G.; Salisbury, J.; Taghavi, S.; Tomalin, I.R.; Zorba, O.

    2004-01-01

    The Front End Driver, FED, is a 9U 400mm VME64x card designed for reading out the Compact Muon Solenoid, CMS, silicon tracker signals transmitted by the APV25 analogue pipeline Application Specific Integrated Circuits. The FED receives the signals via 96 optical fibers at a total input rate of 3.4 GB/sec. The signals are digitized and processed by applying algorithms for pedestal and common mode noise subtraction. Algorithms that search for clusters of hits are used to further reduce the input rate. Only the cluster data along with trigger information of the event are transmitted to the CMS data acquisition system using the S-LINK64 protocol at a maximum rate of 400 MB/sec. All data processing algorithms on the FED are executed in large on-board Field Programmable Gate Arrays. Results on the design, performance, testing and quality control of the FED are presented and discussed.

  18. Rotavirus vaccination in Europe: drivers and barriers.

    Science.gov (United States)

    Parez, N; Giaquinto, C; Du Roure, C; Martinon-Torres, F; Spoulou, V; Van Damme, P; Vesikari, T

    2014-05-01

    Rotavirus gastroenteritis is a vaccine-preventable disease that confers a high medical and economic burden in more developed countries and can be fatal in less developed countries. Two vaccines with high efficacy and good safety profiles were approved and made available in Europe in 2006. We present an overview of the status of rotavirus vaccination in Europe. We discuss the drivers (including high effectiveness and effect of universal rotavirus vaccination) and barriers (including low awareness of disease burden, perception of unfavourable cost-effectiveness, and potential safety concerns) to the implementation of universal rotavirus vaccination in Europe. By February, 2014, national universal rotavirus vaccination had been implemented in Belgium, Luxembourg, Austria, Finland, Greece, Luxembourg, Norway, and the UK. Four other German states have issued recommendations and reimbursement is provided by sickness funds. Other countries were at various stages of recommending or implementing universal rotavirus vaccination. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. Active gated imaging in driver assistance system

    Science.gov (United States)

    Grauer, Yoav

    2014-04-01

    In this paper, we shall present the active gated imaging system (AGIS) in relation to the automotive field. AGIS is based on a fast-gated camera and pulsed illuminator, synchronized in the time domain to record images of a certain range of interest. A dedicated gated CMOS imager sensor and near infra-red (NIR) pulsed laser illuminator, is presented in this paper to provide active gated technology. In recent years, we have developed these key components and learned the system parameters, which are most beneficial to nighttime (in all weather conditions) driving in terms of field of view, illumination profile, resolution, and processing power. We shall present our approach of a camera-based advanced driver assistance systems (ADAS) named BrightEye™, which makes use of the AGIS technology in the automotive field.

  20. Conceptualizing distal drivers in land use competition

    DEFF Research Database (Denmark)

    Niewhöner, Jörg; Nielsen, Jonas Ø; Gasparri, Gasparri

    2016-01-01

    This introductory chapter explores the notion of ‘distal drivers’ in land use competition. Research has moved beyond proximate causes of land cover and land use change to focus on the underlying drivers of these dynamics. We discuss the framework of telecoupling within human–environment systems...... as a first step to come to terms with the increasingly distal nature of driving forces behind land use practices. We then expand the notion of distal as mainly a measure of Euclidian space to include temporal, social, and institutional dimensions. This understanding of distal widens our analytical scope...... for the analysis of land use competition as a distributed process to consider the role of knowledge and power, technology, and different temporalities within a relational or systemic analysis of practices of land use competition. We conclude by pointing toward the historical and social contingency of land use...

  1. Power Plant Retirements: Trends and Possible Drivers

    Energy Technology Data Exchange (ETDEWEB)

    Mills, Andrew D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Wiser, Ryan H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Seel, Joachim [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2017-11-29

    This paper synthesizes available data on historical and planned power plant retirements. Specifically, we present data on historical generation capacity additions and retirements over time, and the types of plants recently retired and planned for retirement. We then present data on the age of plants that have recently retired or that have plans to retire. We also review the characteristics of plants that recently retired or plan to retire vs. those that continue to operate, focusing on plant size, age, heat rate, and SO2 emissions. Finally, we show the level of recent thermal plant retirements on a regional basis and correlate those data with a subset of possible factors that may be contributing to retirement decisions. This basic data synthesis cannot be used to precisely estimate the relative magnitude of retirement drivers. Nor do we explore every possible driver for retirement decisions. Moreover, future retirement decisions may be influenced by different factors than those that have affected past decisions. Nonetheless, it is clear that recently retired plants are relatively old, and that plants with stated planned retirement dates are—on average—no younger. We observe that retired plants are smaller, older, less efficient, and more polluting than operating plants. Based on simple correlation graphics, the strongest predictors of regional retirement differences appear to include SO2 emissions rates (for coal), planning reserve margins (for all thermal units), variations in load growth or contraction (for all thermal units), and the age of older thermal plans (for all thermal units). Additional apparent predictors of regional retirements include the ratio of coal to gas prices and delivered natural gas prices. Other factors appear to have played lesser roles, including the penetration variable renewable energy (VRE), recent non-VRE capacity additions, and whether the region hosts an ISO/RTO.

  2. Numerical simulation of vehicular traffic for non-ideal drivers.

    Science.gov (United States)

    Domínguez, Laura; Amador, Carlos

    2004-03-01

    Numerical simulations of vehicular traffic based on cellular automatae have provided a description of the more relevant experimentally observed properties of the system. Rules for drivers behaviour, though, are highly idealized. In this work we have included rules to mimic the different personalities of drivers: lane changers, passers, over-cautious drivers, tail-gaters, etc. Also we have adopted rules specific to the behaviour of drivers in Mexico City. The whole space of parameters is studied and conclusions are drawn for the effect of this variability on overall vehicular flow. As a further application of the model we study the effect of "shoulder of the road" drivers (who pass congested traffic and return to the main road afterwards) on overall vehicular flow.

  3. Research on Taxi Driver Strategy Game Evolution with Carpooling Detour

    Directory of Open Access Journals (Sweden)

    Wei Zhang

    2018-01-01

    Full Text Available For the problem of taxi carpooling detour, this paper studies driver strategy choice with carpooling detour. The model of taxi driver strategy evolution with carpooling detour is built based on prospect theory and evolution game theory. Driver stable strategies are analyzed under the conditions of complaint mechanism and absence of mechanism, respectively. The results show that passenger’s complaint mechanism can effectively decrease the phenomenon of driver refusing passengers with carpooling detour. When probability of passenger complaint reaches a certain level, the stable strategy of driver is to take carpooling detour passengers. Meanwhile, limiting detour distance and easing traffic congestion can decrease the possibility of refusing passengers. These conclusions have a certain guiding significance to formulating taxi policy.

  4. [The clinical analysis of 51 taxi drivers with peptic ulcer].

    Science.gov (United States)

    Luo, Wen-wen; Zhao, Jie; Fu, Yun-xian; Ma, A-huo

    2012-02-01

    To explore the main pathogenic factor causing the peptic ulcer of taxi drivers, which provide the basis for its prevention. 98 taxi drivers were inspected by electronic endoscopy, according to the inspection all cases were divided into ulcers group and normal group. Then various factors were statuses by the logistic regression analysis according to the results of questionnaire. The prevalence of peptic ulcer of taxi drivers was 52.0%, and logistic regression analysis showed that dining time, taste spicy, meals temperature, smoking,alcohol, mental stress, HP infection and stomach health knowledge were statistically significant (P taxi drivers. By emphasis on diet and lifestyle adjustments, stress regulation on the basis of eradication of HP infection will help the prevention and treatment of peptic ulcer of the taxi driver.

  5. Driver face recognition as a security and safety feature

    Science.gov (United States)

    Vetter, Volker; Giefing, Gerd-Juergen; Mai, Rudolf; Weisser, Hubert

    1995-09-01

    We present a driver face recognition system for comfortable access control and individual settings of automobiles. The primary goals are the prevention of car thefts and heavy accidents caused by unauthorized use (joy-riders), as well as the increase of safety through optimal settings, e.g. of the mirrors and the seat position. The person sitting on the driver's seat is observed automatically by a small video camera in the dashboard. All he has to do is to behave cooperatively, i.e. to look into the camera. A classification system validates his access. Only after a positive identification, the car can be used and the driver-specific environment (e.g. seat position, mirrors, etc.) may be set up to ensure the driver's comfort and safety. The driver identification system has been integrated in a Volkswagen research car. Recognition results are presented.

  6. Influences of vehicle size and mass and selected driver factors on odds of driver fatality.

    Science.gov (United States)

    Padmanaban, Jeya

    2003-01-01

    Research was undertaken to determine vehicle size parameters influencing driver fatality odds, independent of mass, in two-vehicle collisions. Forty vehicle parameters were evaluated for 1,500 vehicle groupings. Logistic regression analyses show driver factors (belt use, age, drinking) collectively contribute more to fatality odds than vehicle factors, and that mass is the most important vehicular parameter influencing fatality odds for all crash configurations. In car crashes, other vehicle parameters with statistical significance had a second order effect compared to mass. In light truck-to-car crashes, "vehicle type-striking vehicle is light truck" was the most important parameter after mass, followed by vehicle height and bumper height, with second order effect. To understand the importance of "vehicle type" variable, further investigation of vehicle "stiffness" and other passenger car/light truck differentiating parameters is warranted.

  7. Opportunities for career advancement found to be very important to truckload drivers

    Science.gov (United States)

    1993-02-01

    This study was conducted to determine what contributes and detracts from job satisfaction for drivers as a means of addressing the driver turnover/retention issue. One factor is that drivers' perception : of the opportunities for advancement within t...

  8. Investigating obesity among professional drivers: the high risk professional driver study.

    Science.gov (United States)

    Rosso, Gian Luca; Perotto, Massimo; Feola, Mauro; Bruno, Graziella; Caramella, Michele

    2015-02-01

    The aim of this study is to detect the main individual and transportation factors associated with obesity and its prevalence among Italian professional drivers (PDs). We performed a cross-sectional questionnaire survey. Data from PDs (n = 497) were used for analyses. Sixty-one percent of participants were either overweight or obese according to their body mass index. Predictive factors for obesity were traveling more than 40,000 miles per year (odds ratio [OR] 4.20, confidence interval [CI] 1.41-12.56) and hours spent behind the wheel per day (OR 1.27, CI 1.02-1.58). Bus drivers had half the risk of being obese compared to truck drivers (OR 0.45, CI 0.23-0.87). An inverse association was detected between educational attainment and obesity (OR 0.32, CI 0.11-0.90). PDs with high number of driving hours per day, miles driven per year, and low educational level should be subject to special educational programs to reduce and prevent obesity. © 2015 Wiley Periodicals, Inc.

  9. Continuous traffic flow modeling of driver support systems in multiclass traffic with intervehicle communication and drivers in the loop

    NARCIS (Netherlands)

    Tampere, C.; Hoogendoorn, S.P.; van Arem, Bart

    2009-01-01

    This paper presents a continuous traffic-flow model for the explorative analysis of advanced driver-assistance systems (ADASs). Such systems use technology (sensors and intervehicle communication) to support the task of the driver, who retains full control over the vehicle. Based on a review of

  10. Age, gender, mileage and the DBQ: The validity of the Driver Behavior Questionnaire in different driver groups

    DEFF Research Database (Denmark)

    Martinussen, Laila Marianne; Hakamies-Blomqvist, Liisa; Møller, Mette

    2013-01-01

    The Driver Behavior Questionnaire (DBQ) is one of the most widely used instruments for measuring selfreported driving behaviors. Despite the popularity of the DBQ, the applicability of the DBQ in different driver groups has remained mostly unexamined. The present study measured aberrant driving...

  11. 78 FR 76757 - Regulatory Guidance on Hours of Service of Drivers Rest Break Requirement; Drivers Who Become...

    Science.gov (United States)

    2013-12-19

    ... Service of Drivers Rest Break Requirement; Drivers Who Become Ineligible for the ``Short-Haul'' Exception... guidance. SUMMARY: This regulatory guidance addresses application of the 30- minute break rule to... exempt from the break rule, but who occasionally exceed the short haul distance or time limits. Such...

  12. Global drivers effect in multi-annual variability of runoff

    Directory of Open Access Journals (Sweden)

    Fendeková Miriam

    2014-09-01

    Full Text Available Changes in runoff parameters are very important for Slovakia, where stream-flow discharges, being supplied by precipitation and groundwater runoff, are preferentially influenced by climatic conditions. Therefore, teleconnections between runoff parameters, climate parameters and global atmospheric drivers such as North Atlantic Oscillation, Southern Pacific Oscillation, Quasi-biennial oscillation and solar activity were studied in the Nitra River Basin, Slovakia. Research was mostly based on records of 80 years (1931-2010 for discharges and baseflow, and 34 years for groundwater heads. Methods of autocorrelation, spectral analysis, cross-correlation and coherence function were used. Results of auto- correllograms for discharges, groundwater heads and base flow values showed a very distinct 11-year and 21-year periodicity. Spectrogram analysis documented the 11-year, 7.8-year, 3.6-year and 2.4-year periods in the discharge, precipitation and air temperature time series. The same cycles except of 11-years were also identified in the long-term series of the North Atlantic Oscillation and Southern Pacific Oscillation indices. The cycle from approximately 2.3 to 2.4-years is most likely connected with Quasi-biennial oscillation. The close negative correlation between the North Atlantic Oscillation winter index and the hydrological surface and groundwater parameters can be used for their prediction within the same year and also for one year in advance.

  13. Drivers of water quality variability in northern coastal Ecuador.

    Science.gov (United States)

    Levy, Karen; Hubbard, Alan E; Nelson, Kara L; Eisenberg, Joseph N S

    2009-03-15

    Microbiological safety of water is commonly measured using indicator organisms, but the spatiotemporal variability of these indicators can make interpretation of data difficult. Here, we systematically explore the variability in Escherichia coil concentrations in surface source and household drinking water in a rural Ecuadorian village over one year. We observed more variability in water quality on an hourly basis (up to 2.4 log difference) than on a daily (2.2 log difference) or weekly basis (up to 1.8 log difference). E. coli counts were higher in the wet season than in the dry season for source (0.42 log difference, p < 0.0001) and household (0.11 log difference, p = 0.077) samples. In the wet season, a 1 cm increase in weekly rainfall was associated with a 3% decrease (p = 0.006) in E. coli counts in source samples and a 6% decrease (p = 0.012) in household samples. Each additional person in the river when source samples were collected was associated with a 4% increase (p = 0.026) in E. coil counts in the wet season. Factors affecting household water quality included rainfall, water source, and covering the container. The variability can be understood as a combination of environmental (e.g., seasonal and soil processes) and other drivers (e.g., human river use, water practices, and sanitation), each working at different time scales.

  14. Cognitive basis about risk level classifications for the self-assessment of older drivers

    OpenAIRE

    Choi, Seong Youl; Lee, Jae Shin

    2017-01-01

    [Purpose] This study analyzed the cognitive functions according to risk level for the Driver 65 Plus measure, and examined the cognitive basis of self-assessment for screening the driving risk of elderly drivers. [Subjects and Methods] A total of 46 older drivers with a driver?s license participated in this study. All participants were evaluated with Driver 65 Plus. They were classified into three groups of ?safe,? ?caution? and ?stop,? and examined for cognitive functions with Trail Making T...

  15. [Health reasons for work disability among municipal transport drivers].

    Science.gov (United States)

    Szubert, Zuzanna; Sobala, Wojciech

    2005-01-01

    The health condition of public transport drivers is one of the factors playing a role in assuring safety of passengers taking use of this kind of transportation means. Therefore, the assessment of pathologies occurring in this occupational group is essential from the prevention point of view. Drivers employed in the municipal transport system are at particular risk. The aim of the study was to define health reasons of work disability among bus and tram drivers in general and to indicate pathologies responsible for disabilities in particular. The study covered 940 drivers (including 788 men and 152 women) employed in a municipal transportation enterprise during the years 1996-2000. Bus (30%) and tram (22%) drivers as well as transport service workers (48%), aged over 45 years, but under the retirement age, were eligible for the study. The analysis of temporary work disability during a five-year period was based on sickness absence, sickness absence rate and the average duration of sickness absence. The analysis revealed that diseases of the circulatory system form the major group of pathologies responsible for total sickness absence among bus drivers (43%), tram drivers (27%) and transport service workers (27%). These disease are also a leading cause of earlier retirement. They mostly include ischemic heart disease in bus drivers and hypertension in tram drivers. Cancers (pleura, kidney and eye) were responsible for 9% of sickness absence in the group of male tram drivers, whereas endocrine, nutritional and metabolic diseases and immunity disorders (diabetes, disorders of thyroid gland) in 16% of female tram drivers. Diseases of the musculoskeletal system were major causes of sickness absence among female tram drivers (24%), whereas malignant and benign neoplasms of breast and uterine myoma in 24% of female transport service workers. The results of the analysis are in agreement with the literature findings and provide explicit evidence that employment in the

  16. Spatial clustering and meteorological drivers of summer ozone in Europe

    Science.gov (United States)

    Carro-Calvo, Leopoldo; Ordóñez, Carlos; García-Herrera, Ricardo; Schnell, Jordan L.

    2017-10-01

    We have applied the k-means clustering technique on a maximum daily 8-h running average near-surface ozone (MDA8 O3) gridded dataset over Europe at 1° × 1° resolution for summer 1998-2012. This has resulted in a spatial division of nine regions where ozone presents coherent spatiotemporal patterns. The role of meteorology in the variability of ozone at different time scales has been investigated by using daily meteorological fields from the NCEP-NCAR meteorological reanalysis. In the five regions of central-southern Europe ozone extremes (exceedances of the summer 95th percentile) occur mostly under anticyclonic circulation or weak sea level pressure gradients which trigger elevated temperatures and the recirculation of air masses. In the four northern regions extremes are associated with high-latitude anticyclones that divert the typical westerly flow at those latitudes and cause the advection of aged air masses from the south. The impact of meteorology on the day-to-day variability of ozone has been assessed by means of two different types of multiple linear models. These include as predictors meteorological fields averaged within the regions (;region-based; approach) or synoptic indices indicating the degree of resemblance between the daily meteorological fields over a large domain (25°-70° N, 35° W - 35° E) and their corresponding composites for extreme ozone days (;index-based; approach). With the first approach, a reduced set of variables, always including daily maximum temperature within the region, explains 47-66% of the variability (adjusted R2) in central-southern Europe, while more complex models are needed to explain 27-49% of the variability in the northern regions. The index-based approach yields better results for the regions of northern Europe, with adjusted R2 = 40-57%. Finally, both methodologies have also been applied to reproduce the interannual variability of ozone, with the best models explaining 66-88% of the variance in central

  17. Interannual drivers of the seasonal cycle of CO2 in the Southern Ocean

    Science.gov (United States)

    Gregor, Luke; Kok, Schalk; Monteiro, Pedro M. S.

    2018-04-01

    concentrations. In regions of low chlorophyll a concentrations, wind stress and sea surface temperature emerged as stronger drivers of ΔpCO2. In summary we propose that sub-decadal variability is explained by summer drivers, while winter variability contributes to the long-term changes associated with the SAM. This approach is a useful framework to assess the drivers of ΔpCO2 but would greatly benefit from improved estimates of ΔpCO2 and a longer time series.

  18. Discriminating Drivers through Human Factor and Behavioral Difference

    Directory of Open Access Journals (Sweden)

    Ju Seok Oh

    2011-05-01

    Full Text Available Since Greenwood and Woods' (1919 study in tendency of accident, many researchers have insisted that various human factors (sensation seeking, anger, anxiety are highly correlated with reckless driving and traffic accidents. Oh and Lee (2011 designed the Driving Behavior Determinants Questionnaire, a psychological tool to predict danger level of drivers and discriminate them into three groups (normal, unintentionally reckless, and intentionally reckless by their characteristics, attitude, and expected reckless behavior level. This tool's overall accuracy of discrimination was 70%. This study aimed to prove that the discrimination reflects the behavioral difference of drivers. Twenty-four young drivers were requested to react to the visual stimuli (tests for subjective speed sense, simple visual reaction time, and left turning at own risk. The results showed no differences in subjective speed sense among the driver groups, which means drivers' excessive speeding behaviors occur due to intention based on personality and attitude, not because of sensory disorders. In addition, there were no differences in simple reaction time among driver groups. However, the results of the ‘Left turning at drivers’ own risk task” revealed significant group differences. All reckless drivers showed a greater degree of dangerous left turning behaviors than the normal group did.

  19. Does automatic transmission improve driving behavior in older drivers?

    Science.gov (United States)

    Selander, Helena; Bolin, Ingrid; Falkmer, Torbjörn

    2012-01-01

    Most older drivers continue to drive as they age. To maintain safe and independent transport, mobility is important for all individuals, but especially for older drivers. The objective of this study was to investigate whether automatic transmission, compared with manual transmission, may improve the driving behavior of older drivers. In total, 31 older drivers (mean age 75.2 years) and 32 younger drivers - used as a control group (mean age 39.2 years) - were assessed twice on the same fixed route; once in a car with manual transmission and once in a car with automatic transmission. The cars were otherwise identical. The driving behavior was assessed with the Ryd On-Road Assessment driving protocol. Time to completion of left turns (right-hand side driving) and the impact of a distraction task were measured. The older group had more driving errors than the younger group, in both the manual and the automatic transmission car. However, and contrary to the younger drivers, automatic transmission improved the older participants' driving behavior as demonstrated by safer speed adjustment in urban areas, greater maneuvering skills, safer lane position and driving in accordance with the speed regulations. Switching to automatic transmission may be recommended for older drivers as a means to maintain safe driving and thereby the quality of their transport mobility. Copyright © 2011 S. Karger AG, Basel.

  20. Lower back pain and absenteeism among professional public transport drivers.

    Science.gov (United States)

    Kresal, Friderika; Roblek, Vasja; Jerman, Andrej; Meško, Maja

    2015-01-01

    Drivers in public transport are subjected to lower back pain. The reason for the pain is associated with the characteristics of the physical position imposed on the worker while performing the job. Lower back pain is the main cause of absenteeism among drivers. The present study includes 145 public transport drivers employed as professional drivers for an average of 14.14 years. Analysis of the data obtained in the study includes the basic descriptive statistics, χ(2) test and multiple regression analysis. Analysis of the incidence of lower back pain showed that the majority of our sample population suffered from pain in the lower back. We found that there are no statistically significant differences between the groups formed by the length of service as a professional driver and incidence of lower back pain; we were also interested in whether or not the risk factors of lower back pain affects the absenteeism of city bus drivers. Analysis of the data has shown that the risk factors of pain in the lower part of the spine do affect the absenteeism of city bus drivers.