WorldWideScience

Sample records for support structures selected

  1. Effect of adding support structures for overhanging part on fatigue strength in selective laser melting.

    Science.gov (United States)

    Kajima, Yuka; Takaichi, Atsushi; Nakamoto, Takayuki; Kimura, Takahiro; Kittikundecha, Nuttaphon; Tsutsumi, Yusuke; Nomura, Naoyuki; Kawasaki, Akira; Takahashi, Hidekazu; Hanawa, Takao; Wakabayashi, Noriyuki

    2018-02-01

    Selective laser melting (SLM) technology was recently introduced to fabricate dental prostheses. However, the fatigue strength of clasps in removable partial dentures prepared by SLM still requires improvement. In this study, we attempted to improve the fatigue strength of clasps by adding support structures for overhanging parts, which can generally be manufactured at an angle to be self-supporting. The results show that the fatigue strength of the supported specimens was more than twice that of unsupported specimens. Electron back-scattered diffraction analysis revealed that the supported specimens exhibited lower kernel average misorientation values than the unsupported specimens, which suggested that the support structure reduced the residual strain during the SLM process and helped to prevent micro-cracks led by thermal distortion. In addition, the supported specimens cooled more rapidly, thereby forming a finer grain size compared to that of the unsupported specimens, which contributed to improving the fatigue strength. The results of this study suggest that the fatigue strength of overhanging parts can be improved by intentionally adding support structures. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Evaluation of mechanical properties in metal wire mesh supported selective catalytic reduction (SCR) catalyst structures

    Science.gov (United States)

    Rajath, S.; Siddaraju, C.; Nandakishora, Y.; Roy, Sukumar

    2018-04-01

    The objective of this research is to evaluate certain specific mechanical properties of certain stainless steel wire mesh supported Selective catalytic reduction catalysts structures wherein the physical properties of the metal wire mesh and also its surface treatments played vital role thereby influencing the mechanical properties. As the adhesion between the stainless steel wire mesh and the catalyst material determines the bond strength and the erosion resistance of catalyst structures, surface modifications of the metal- wire mesh structure in order to facilitate the interface bonding is therefore very important to realize enhanced level of mechanical properties. One way to enhance such adhesion properties, the stainless steel wire mesh is treated with the various acids, i.e., chromic acid, phosphoric acid including certain mineral acids and combination of all those in various molar ratios that could generate surface active groups on metal surface that promotes good interface structure between the metal- wire mesh and metal oxide-based catalyst material and then the stainless steel wire mesh is dipped in the glass powder slurry containing some amount of organic binder. As a result of which the said catalyst material adheres to the metal-wire mesh surface more effectively that improves the erosion profile of supported catalysts structure including bond strength.

  3. Design of Offshore Wind Turbine Support Structures: Selected topics in the field of geotechnical engineering

    DEFF Research Database (Denmark)

    Bakmar, Christian LeBlanc

    .D. thesis was to enable low-cost and low-risk support structures to be designed in order to improve the economic feasibility of future offshore wind farms. The research work was divided in the following four selected research topics in the field of geotechnical engineering, relating to the monopile......Breaking the dependence on fossil fuels offers many opportunities for strengthened competitiveness, technological development and progress. Offshore wind power is a domestic, sustainable and largely untapped energy resource that provides an alternative to fossil fuels, reduces carbon emissions......, and decreases the economic and supply risks associated with reliance on imported fuels. Today, the modern offshore wind turbine offers competitive production prices for renewable energy and is therefore a key technology in achieving the energy and climate goals of the future. The overall aim of this Ph...

  4. [Selection of occlusal scheme on the basis of pressure distribution on supporting structures under complete dentures].

    Science.gov (United States)

    Nagao, Kan; Kawano, Fumiaki; Ichikawa, Tetsuo

    2004-12-01

    In case of making complete dentures, we have to consider not only denture stability but also the restoration of aesthetics and function such as mastication and speech. However these are contradictory theoretically from the point of view of denture stability, and it is very difficult to satisfy both requirements in the case of a patient who has poor upper and lower alveolar ridges. We investigated the effect of artificial posterior teeth form and occlusal scheme on the distribution of pressure on supporting structures under complete dentures during mastication with upper and lower edentulous simulators. In this report, a guideline for the selection of occlusal scheme for complete dentures, based on our previous investigations, is described. The occlusal scheme remarkably affected the distribution of pressure under simulated complete dentures, as shown by comparing the distribution of pressure using two different occlusal schemes:fully balanced occlusion and lingualized occlusion. However other factors such as posterior teeth form and position affect the distribution of pressure as well, and are related to each other. Therefore, not only occlusal scheme but also posterior artificial teeth form has to be considered, and the form of posterior teeth should be carefully and comprehensively decided when making complete dentures.

  5. The Impact of the Support System’s Kinematic Structure on Selected Kinematic and Dynamic Quantities of an Experimental Crane

    Directory of Open Access Journals (Sweden)

    Trąbka Arkadiusz

    2014-12-01

    Full Text Available This paper presents a comparative analysis of two kinematic structures of the support system (with supports with bilateral and unilateral constraints, which were used in an experimental model of a crane. The computational model was developed by using the ADAMS software. The impact of the kinematic structure of the support system on selected kinematic and dynamic values that were recorded during the slewing motion was analysed. It was found, among other things, that an increased number of degrees of freedom of the support system leads to multiple distortions of time characteristics of kinematic and dynamic quantities.

  6. Structural Evolution under Reaction Conditions of Supported (NH43HPMo11VO40 Catalysts for the Selective Oxidation of Isobutane

    Directory of Open Access Journals (Sweden)

    Fangli Jing

    2015-03-01

    Full Text Available When using heteropolycompounds in the selective oxidation of isobutane to methacrolein and methacrylic acid, both the keeping of the primary structure (Keggin units and the presence of acidic sites are necessary to obtain the desired products. The structural evolution of supported (NH43HPMo11VO40 (APMV catalysts under preliminary thermal oxidizing and reducing treatments was investigated. Various techniques, such as TGA/DTG (Thermo-Gravimetric Analysis/Derivative Thermo-Gravimetry, H2-TPR (Temperature Programed Reduction, in situ XRD (X-Ray Diffraction and XPS (X-ray Photoelectron Spectroscopy, were applied. It was clearly evidenced that the thermal stability and the reducibility of the Keggin units are improved by supporting 40% APMV active phase on Cs3PMo12O40 (CPM. The partial degradation of APMV takes place depending on temperature and reaction conditions. The decomposition of ammonium cations (releasing NH3 leads to the formation of vacancies favoring cationic exchanges between vanadium coming from the active phase and cesium coming from the support. In addition, the vanadium expelled from the Keggin structure is further reduced to V4+, species, which contributes (with Mo5+ to activate isobutane. The increase in reducibility of the supported catalyst is assumed to improve the catalytic performance in comparison with those of unsupported APMV.

  7. Pragmatic, consensus-based minimum standards and structured interview to guide the selection and development of cancer support group leaders: a protocol paper.

    Science.gov (United States)

    Pomery, Amanda; Schofield, Penelope; Xhilaga, Miranda; Gough, Karla

    2017-06-30

    Across the globe, peer support groups have emerged as a community-led approach to accessing support and connecting with others with cancer experiences. Little is known about qualities required to lead a peer support group or how to determine suitability for the role. Organisations providing assistance to cancer support groups and their leaders are currently operating independently, without a standard national framework or published guidelines. This protocol describes the methods that will be used to generate pragmatic consensus-based minimum standards and an accessible structured interview with user manual to guide the selection and development of cancer support group leaders. We will: (A) identify and collate peer-reviewed literature that describes qualities of support group leaders through a systematic review; (B) content analyse eligible documents for information relevant to requisite knowledge, skills and attributes of group leaders generally and specifically to cancer support groups; (C) use an online reactive Delphi method with an interdisciplinary panel of experts to produce a clear, suitable, relevant and appropriate structured interview comprising a set of agreed questions with behaviourally anchored rating scales; (D) produce a user manual to facilitate standard delivery of the structured interview; (E) pilot the structured interview to improve clinical utility; and (F) field test the structured interview to develop a rational scoring model and provide a summary of existing group leader qualities. The study is approved by the Department Human Ethics Advisory Group of The University of Melbourne. The study is based on voluntary participation and informed written consent, with participants able to withdraw at any time. The results will be disseminated at research conferences and peer review journals. Presentations and free access to the developed structured interview and user manual will be available to cancer agencies. © Article author(s) (or their

  8. Selective structural source identification

    Science.gov (United States)

    Totaro, Nicolas

    2018-04-01

    In the field of acoustic source reconstruction, the inverse Patch Transfer Function (iPTF) has been recently proposed and has shown satisfactory results whatever the shape of the vibrating surface and whatever the acoustic environment. These two interesting features are due to the virtual acoustic volume concept underlying the iPTF methods. The aim of the present article is to show how this concept of virtual subsystem can be used in structures to reconstruct the applied force distribution. Some virtual boundary conditions can be applied on a part of the structure, called virtual testing structure, to identify the force distribution applied in that zone regardless of the presence of other sources outside the zone under consideration. In the present article, the applicability of the method is only demonstrated on planar structures. However, the final example show how the method can be applied to a complex shape planar structure with point welded stiffeners even in the tested zone. In that case, if the virtual testing structure includes the stiffeners the identified force distribution only exhibits the positions of external applied forces. If the virtual testing structure does not include the stiffeners, the identified force distribution permits to localize the forces due to the coupling between the structure and the stiffeners through the welded points as well as the ones due to the external forces. This is why this approach is considered here as a selective structural source identification method. It is demonstrated that this approach clearly falls in the same framework as the Force Analysis Technique, the Virtual Fields Method or the 2D spatial Fourier transform. Even if this approach has a lot in common with these latters, it has some interesting particularities like its low sensitivity to measurement noise.

  9. Fuel assembly supporting structure

    International Nuclear Information System (INIS)

    Aisch, F.W.; Fuchs, H.P.; Knoedler, D.; Steinke, A.; Steven, J.

    1976-01-01

    For use in forming the core of a pressurized-water reactor, a fuel assembly supporting structure for holding a bundle of interspaced fuel rods, is formed by interspaced end pieces having holes in which the end portions of control rod guide tubes are inserted, fuel rod spacer grids being positioned by these guide tubes between the end pieces. The end pieces are fastened to the end portions of the guide tubes, to integrate the supporting structure, and in the case of at least one of the end pieces, this is done by means which releases that end piece from the guide tubes when the end pieces receive an abnormal thrust force directed towards each other and which would otherwise place the guide tubes under a compressive stress that would cause them to buckle. The spacer grids normally hold the fuel rods interspaced by distances determined by nuclear physics, and buckling of the control rod guide tubes can distort the fuel rod spacer grids with consequent dearrangement of the fuel rod interspacing. A sudden loss of pressure in a pressurized-water reactor pressure vessel can result in the pressurized coolant in the vessel discharging from the vessel at such high velocity as to result in the abnormal thrust force on the end pieces of each fuel assembly, which could cause buckling of the control rod guide tubes when the end pieces are fixed to them in the normal rigid and unyielding manner

  10. Evaluation of selected environmental decision support software

    International Nuclear Information System (INIS)

    Sullivan, T.M.; Moskowitz, P.D.; Gitten, M.

    1997-06-01

    Decision Support Software (DSS) continues to be developed to support analysis of decisions pertaining to environmental management. Decision support systems are computer-based systems that facilitate the use of data, models, and structured decision processes in decision making. The optimal DSS should attempt to integrate, analyze, and present environmental information to remediation project managers in order to select cost-effective cleanup strategies. The optimal system should have a balance between the sophistication needed to address the wide range of complicated sites and site conditions present at DOE facilities, and ease of use (e.g., the system should not require data that is typically unknown and should have robust error checking of problem definition through input, etc.). In the first phase of this study, an extensive review of the literature, the Internet, and discussions with sponsors and developers of DSS led to identification of approximately fifty software packages that met the preceding definition

  11. Selected topics in nuclear structure

    International Nuclear Information System (INIS)

    1994-01-01

    The collection of abstracts on selected topics in nuclear structure are given. Special attention pays to collective excitations and high-spin states of nuclei, giant resonance structure, nuclear reaction mechanisms and so on

  12. Aseismatic supporting structures

    International Nuclear Information System (INIS)

    Ogasawara, Hideo; Tachi, Yasuo

    1988-01-01

    As one of the large subjects for putting FBRs to practical use, the increase of the economical efficiency is pointed out, and for this purpose, the reduction of the construction cost by the simplification of system and the rationalization of equipment structures becomes an important target of development. The operational condition of FBR cooling system is high temperature above 500 deg C at core exit, and low pressure below 6 kg-cm 2 g. Consequently, the effect of earthquake load in the structural strength design is relatively large, accordingly the reduction of earthquake load is effective from the viewpoint of structural rationalization. Hitachi Ltd. considered that earthquake isolation is an effective means to reduce earthquake response, and has examined the effect and feasibility of introducing earthquake isolation into FBR plants for three years from 1984. In this study, the mechanical characteristics and endurance of the system suitable to the earthquake isolation of FBRs were examined, the effect of reducing earthquake response by earthquake isolation was grasped, and the effect of plant rationalization brought about by the reduction of earthquake input was examined. The summary of these studies is shown. (Kako, I.)

  13. Selected topics in nuclear structure

    International Nuclear Information System (INIS)

    Solov'ev, V.G.; Gromov, K.Ya.; Malov, L.A.; Shilov, V.M.

    1994-01-01

    The Fourth International Conference on selected topics in nuclear structure was held at Dubna in July 1994 on recent experimental and theoretical investigations in nuclear structure. Topics discussed were the following: nuclear structure at low-energy excitations (collective quasiparticle phenomena, proton-neutron interactions, microscopic and phenomenological theories of nuclear structure; nuclear structure studies with charged particles. heavy ions, neutrons and photons; nuclei at high angular momenta and superdeformation, structure and decay properties of giant resonances, charge-exchange resonances and β-decay; semiclassical approach of large amplitude collective motion and structure of hot nuclei

  14. Selected topics in nuclear structure

    Energy Technology Data Exchange (ETDEWEB)

    Solov` ev, V G; Gromov, K Ya; Malov, L A; Shilov, V M

    1994-12-31

    The Fourth International Conference on selected topics in nuclear structure was held at Dubna in July 1994 on recent experimental and theoretical investigations in nuclear structure. Topics discussed were the following: nuclear structure at low-energy excitations (collective quasiparticle phenomena, proton-neutron interactions, microscopic and phenomenological theories of nuclear structure; nuclear structure studies with charged particles). heavy ions, neutrons and photons; nuclei at high angular momenta and superdeformation, structure and decay properties of giant resonances, charge-exchange resonances and {beta}-decay; semiclassical approach of large amplitude collective motion and structure of hot nuclei.

  15. Opportunity structures for selective exposure

    DEFF Research Database (Denmark)

    Skovsgaard, Morten; Shehata, Adam; Strömbäck, Jesper

    2016-01-01

    Abstract The transition from low-choice to high-choice media environments has raised new concerns about selective exposure. In this context, two types of selective media exposure are relevant. One is selectivity based on political ideological preferences, the other selectivity based on political...... interest. Evidence for both has been found primarily in an American context, while there is less research on European countries. This is problematic, as the opportunity structures for different forms of selectivity vary across media environments. Against this background, the purpose of this study...

  16. Decision support system to select cover systems

    International Nuclear Information System (INIS)

    Bostick, K.V.

    1995-01-01

    The objective of this technology is to provide risk managers with a defensible, objective way to select capping alternatives for remediating radioactive and mixed waste landfills. The process of selecting containment cover technologies for mixed waste landfills requires consideration of many complex and interrelated technical, regulatory, and economic issues. A Decision Support System (DSS) is needed to integrate the knowledge of experts from scientific, engineering, and management disciplines to help in selecting the best capping practice for the site

  17. Large coil program support structure conceptual design

    International Nuclear Information System (INIS)

    Litherland, P.S.

    1977-01-01

    The purpose of the Large Coil Program (LCP) is to perform tests on both pool boiling and force cooled superconducting toroidal field coils. The tests will attempt to approximate conditions anticipated in an ignition tokamak. The test requirements resulted in a coil support design which accommodates up to six (6) test coils and is mounted to a structure capable of resisting coil interactions. The steps leading to the present LCP coil support structure design, details on selected structural components, and the basic assembly sequence are discussed

  18. Selected topics in nuclear structure

    International Nuclear Information System (INIS)

    Stachura, Z.

    1984-09-01

    19. winter school in Zakopane was devoted to selected topics in nuclear structure such as: production of spin resonances, heavy ions reactions and their applications to the investigation of high spin states, octupole deformations, excited states and production of new elements etc. The experimental data are ofen compared with theoretical predictions. Report contains 28 papers. (M.F.W.)

  19. A review of methods supporting supplier selection

    NARCIS (Netherlands)

    de Boer, L.; Labro, Eva; Morlacchi, Pierangela

    2001-01-01

    this paper we present a review of decision methods reported in the literature for supporting the supplier selection process. The review is based on an extensive search in the academic literature. We position the contributions in a framework that takes the diversity of procurement situations in terms

  20. Proposal for structure of the national system for support of sustainable tourism and a methodology of rating of selected tourist services

    Directory of Open Access Journals (Sweden)

    Michal Burian

    2005-01-01

    Full Text Available This thesis is focused on preparation of basic elements of the National System for Support of Sustainable Tourism in the Czech Republic and on development of a methodology for ranking of selected tourist services from the sustainable point of view. Its result is planned to be used as a basis for real decisions potentially taken by the Czech government in near future.The first part analyses and summarises existing approaches worldwide to sustainable tourism, potential benefits and different impacts of tourism in order to specify possible measures avoiding unwanted impacts later on. The need to change towards sutainability in tourism is based on analysis of different policies and documents and a summary of duties of the Czech government (national ones and international ones. There is also a list of the best experiences available how to promote, support and encourage development of sustainable tourism based on analysis of the World Tourism Organisation studies and recommendations, existing EMS systems like ISO, EU ecolabel or methods, approaches, criteria and indicators used by different labels.Next part defines neccessary elements for successful system functioning in the Czech Republic, based on existing and working governmental and non-governmental structures not forgetting such important activities like information, education, marketing and motivation and sets expected responsibilities and roles of different potential partners participating on the system implementation.Unfortunately, there is no one certified tourist business in Czechia according to ISO, EMAS or EU flower before end of October 2004. Main reasons are price, missing benefits and motivations for businesses. Therefore an self-assesment questionnaire for a small-scale accommodation is developed. This fits with the „easy to understand, easy to answer“. This option is missing in the country and it is understood as a prestep to more sophisticated methods of measurment. The main

  1. Selection of support structure materials for irradiation experiments in the HFIR [High Flux Isotope Reactor] at temperatures up to 500 degrees C

    International Nuclear Information System (INIS)

    Farrell, K.; Longest, A.W.

    1990-01-01

    The key factor in the design of capsules for irradiation of test specimens in the High Flux Isotope Reactor at preselected temperatures up to 500 degree C utilizing nuclear heating is a narrow gas-filled gap which surrounds the specimens and controls the transfer of heat from the specimens through the wall of a containment tube to the reactor cooling water. Maintenance of this gap to close tolerances is dependent on the characteristics of the materials used to support the specimens and isolate them from the water. These support structure materials must have low nuclear heating rates, high thermal conductivities, and good dimensional stabilities under irradiation. These conditions are satisfied by certain aluminum alloys. One of these alloys, a powder metallurgy product containing a fine dispersion of aluminum oxide, is no longer manufactured. A new alloys of this type, with the trade name DISPAL, is determined to be a suitable substitute. 23 refs., 13 figs., 3 tabs

  2. Support Schemes and Ownership Structures

    DEFF Research Database (Denmark)

    Ropenus, Stephanie; Schröder, Sascha Thorsten; Costa, Ana

    , Denmark, France and Portugal. Another crucial aspect for the diffusion of the mCHP technology is possible ownership structures. These may range from full consumer ownership to ownership by utilities and energy service companies, which is discussed in Section 6. Finally, a conclusion (Section 7) wraps up......In recent years, fuel cell based micro‐combined heat and power has received increasing attention due to its potential contribution to energy savings, efficiency gains, customer proximity and flexibility in operation and capacity size. The FC4Home project assesses technical and economic aspects...... of support scheme simultaneously affects risk and technological development, which is the focus of Section 4. Subsequent to this conceptual overview, Section 5 takes a glance at the national application of support schemes for mCHP in practice, notably in the three country cases of the FC4Home project...

  3. Palladium nanoparticles supported on fibrous-structured silica nanospheres (KCC-1): An efficient and selective catalyst for the transfer hydrogenation of alkenes

    KAUST Repository

    Qureshi, Ziyauddin; Sarawade, Pradip; Albert, Matthias; D'Elia, Valerio; Hedhili, Mohamed Nejib; Kö hler, Klaus; Basset, Jean-Marie

    2015-01-01

    An efficient palladium catalyst supported on fibrous silica nanospheres (KCC-1) has been developed for the hydrogenation of alkenes and α,β-unsaturated carbonyl compounds, providing excellent yields of the corresponding products with remarkable chemoselectivity. Comparison (high-resolution TEM, chemisorption) with analogous mesoporous (MCM-41, SBA-15) silica-supported Pd nanocatalysts prepared under identical conditions, demonstrates the advantage of employing the fibrous KCC-1 morphology versus traditional supports because it ensures superior accessibility of the catalytically active cores along with excellent Pd dispersion at high metal loading. This morphology ultimately leads to higher catalytic activity for the KCC-1-supported nanoparticles. The protocol developed for hydrogenation is advantageous and environmentally benign owing to the use of HCOOH as a source of hydrogen, water as a solvent, and because of efficient catalyst recyclability and durability. The recycled catalyst has been analyzed by XPS spectroscopy and TEM showing only minor changes in the oxidation state of Pd and in the morphology after the reaction, thus confirming the robustness of the catalyst.

  4. Palladium nanoparticles supported on fibrous-structured silica nanospheres (KCC-1): An efficient and selective catalyst for the transfer hydrogenation of alkenes

    KAUST Repository

    Qureshi, Ziyauddin

    2015-01-09

    An efficient palladium catalyst supported on fibrous silica nanospheres (KCC-1) has been developed for the hydrogenation of alkenes and α,β-unsaturated carbonyl compounds, providing excellent yields of the corresponding products with remarkable chemoselectivity. Comparison (high-resolution TEM, chemisorption) with analogous mesoporous (MCM-41, SBA-15) silica-supported Pd nanocatalysts prepared under identical conditions, demonstrates the advantage of employing the fibrous KCC-1 morphology versus traditional supports because it ensures superior accessibility of the catalytically active cores along with excellent Pd dispersion at high metal loading. This morphology ultimately leads to higher catalytic activity for the KCC-1-supported nanoparticles. The protocol developed for hydrogenation is advantageous and environmentally benign owing to the use of HCOOH as a source of hydrogen, water as a solvent, and because of efficient catalyst recyclability and durability. The recycled catalyst has been analyzed by XPS spectroscopy and TEM showing only minor changes in the oxidation state of Pd and in the morphology after the reaction, thus confirming the robustness of the catalyst.

  5. Performance of pile supported sign structures : [brief].

    Science.gov (United States)

    2015-05-01

    Sign structures in Wisconsin are typically supported by drilled shaft foundations or spread : footing foundations. However, when the soil conditions are not suitable to be supported on : drilled shafts or spread footings, a group of piles could suppo...

  6. Selective hydrogenation of citral over supported Pt catalysts: insight into support effects

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xiaofeng [Missouri University of Science and Technology, Department of Chemical and Biochemical Engineering (United States); Hu, Weiming; Deng, Baolin [University of Missouri, Department of Civil and Environmental Engineering (United States); Liang, Xinhua, E-mail: liangxin@mst.edu [Missouri University of Science and Technology, Department of Chemical and Biochemical Engineering (United States)

    2017-04-15

    Highly dispersed platinum (Pt) nanoparticles (NPs) were deposited on various substrates by atomic layer deposition (ALD) in a fluidized bed reactor at 300 °C. The substrates included multi-walled carbon nanotubes (MWCNTs), silica gel (SiO{sub 2}), commercial γ-Al{sub 2}O{sub 3}, and ALD-prepared porous Al{sub 2}O{sub 3} particles (ALD-Al{sub 2}O{sub 3}). The results of TEM analysis showed that ~1.3 nm Pt NPs were highly dispersed on all different supports. All catalysts were used for the reaction of selective hydrogenation of citral to unsaturated alcohols (UA), geraniol, and nerol. Both the structure and acidity of supports affected the activity and selectivity of Pt catalysts. Pt/SiO{sub 2} showed the highest activity due to the strong acidity of SiO{sub 2} and the conversion of citral reached 82% after 12 h with a selectivity of 58% of UA. Pt/MWCNTs showed the highest selectivity of UA, which reached 65% with a conversion of 38% due to its unique structure and electronic effect. The cycling experiments indicated that Pt/MWCNTs and Pt/ALD-Al{sub 2}O{sub 3} catalysts were more stable than Pt/SiO{sub 2}, as a result of the different interactions between the Pt NPs and the supports.

  7. Selected topics in nuclear structure

    International Nuclear Information System (INIS)

    Faessler, A.

    1990-01-01

    Today's dream of nuclear structure physics is to calculate the properties of nuclei starting from Quantum-Chromodynamics (QCD). However, we are definitely not able to do that today and may be even in the future one would wish only to show in principle that this is possible. It probably will never be a daily approach to study excitation energies, transitions probabilities and other properties of nuclei. This paper discusses the possibility of coming from the shore of QCD to the other side of the river, to nuclear structure, not in one great arch buy like medieval bridges in several arches grounded each solidly on pillars going down to the river floor and by that connecting theory with the solid ground of experiments. The first arch is meant to connect QCD and the nucleon-nucleon phase shifts with the help to the nucleon-nucleon phase shifts with the experimentally fitted effective interactions for the final model spaces used in nuclear structure calculations. This is at the moment still by far the weakest arch although a large amount of work and ideas have been invested since about the middle of the 60's to derive a theory of effective interactions and to establish the connection of the effective interaction fitted to nuclear structure data with the bare interaction between nucleons in the vacuum. The last arch is connecting the effective nucleon-nucleon interaction with nuclear structure properties

  8. Support system of a structure on a support base

    International Nuclear Information System (INIS)

    Arene, G.; Renaux, C.; Minguet, J.L.; Chantot, H.

    1984-01-01

    Two series of strips are fixed to the structure to be supported and to the base to define each one a closed convex envelope; the strips are flexible in the radial direction with regard to the envelope. The two series of strips are connected by a treillis of rigid bars set to form juxtaposed V or X. A good transversal rigidity and a certain radial flexibility are obtained. The invention can be applied to a fast neutron nuclear reactor, the reactor comprising a vertical axis vessel filled with liquid metal; the vessel rests on a support foundation by means of the support system proposed by the invention. The support system allows the supported structure to resist the effects of an eventual earthquake and brutal temperature variations [fr

  9. Outranking methods in support of supplier selection

    NARCIS (Netherlands)

    de Boer, L.; van der Wegen, Leonardus L.M.; Telgen, Jan

    1998-01-01

    Initial purchasing decisions such as make-or-buy decisions and supplier selection are decisions of strategic importance to companies. The nature of these decisions usually is complex and unstructured. Management Science techniques might be helpful tools for this kind of decision making problems. So

  10. Towards Automatic Decentralized Control Structure Selection

    DEFF Research Database (Denmark)

    for decentralized control is determined automatically, and the resulting decentralized control structure is automatically tuned using standard techniques. Dynamic simulation of the resulting process system gives immediate feedback to the process design engineer regarding practical operability of the process......A subtask in integration of design and control of chemical processes is the selection of a control structure. Automating the selection of the control structure enables sequential integration of process and controld esign. As soon as the process is specified or computed, a structure....... The control structure selection problem is formulated as a special MILP employing cost coefficients which are computed using Parseval's theorem combined with RGA and IMC concepts. This approach enables selection and tuning of large-scale plant-wide decentralized controllers through efficient combination...

  11. Towards Automatic Decentralized Control Structure Selection

    DEFF Research Database (Denmark)

    Jørgensen, John Bagterp; Jørgensen, Sten Bay

    2000-01-01

    for decentralized control is determined automatically, and the resulting decentralized control structure is automatically tuned using standard techniques. Dynamic simulation of the resulting process system gives immediate feedback to the process design engineer regarding practical operability of the process......A subtask in integration of design and control of chemical processes is the selection of a control structure. Automating the selection of the control structure enables sequential integration of process and control design. As soon as the process is specified or computed, a structure....... The control structure selection problem is formulated as a special MILP employing cost coefficients which are computed using Parseval's theorem combined with RGA and IMC concepts. This approach enables selection and tuning of large-scale plant-wide decentralized controllers through efficient combination...

  12. Cryogenic structural material and design of support structures for the Large Helical Device

    International Nuclear Information System (INIS)

    Nishimura, Arata; Imagawa, Shinsaku; Tamura, Hitoshi

    1997-01-01

    This paper describes a short history of material selection for the cryogenic support structures for the Large Helical Device (LHD) which has superconducting coils. Since the support structures are cooled down to 4.4 K together with the coils, SUS 316 was chosen because of its stable austenitic phase, sufficient mechanical properties at cryogenic temperature and good weldability. Also, outlines of the design and fabrication processes of the support structures are summarized. On the design of the support structures, a deformation analysis was carried out to maintain the proper magnetic field during operation. Afterwards, a stress analysis was performed. During machining and assembling, tolerance was noticed to keep coil positions accurate. Special welding grooves and fabrication processes were considered and achieved successfully. Finally, a cryogenic supporting post which sustains the cryogenic structures and superconducting coils is presented. CFRP was used in this specially developed supporting post to reduce the heat conduction from ambient 300 K structures. (author)

  13. Organizational Structures that Support Internal Program Evaluation

    Science.gov (United States)

    Lambur, Michael T.

    2008-01-01

    This chapter explores how the structure of large complex organizations such as Cooperative Extension affects their ability to support internal evaluation of their programs and activities. Following a literature review of organizational structure and its relation to internal evaluation capacity, the chapter presents the results of interviews with…

  14. Core support structure for nuclear power plants

    International Nuclear Information System (INIS)

    Steinkamp, E.; Tautz, J.; Ries, H.

    1979-01-01

    A core support structure for nuclear power plants includes a grid of mutually crossing bridges and a support ring surrounding the grid and connected to ends of the outer bridges of the grid, the grid being formed of profile rod crosses having legs of given length, respective legs of pairs of adjacent crosses abutting one another endwise to form together a side of the smallest mesh opening of the grid, and weld means for securing the profile rod crosses to one another at the mutually abutting ends of the legs thereof; and method of producing the foregoing core support structure

  15. Effect of support conditions on structural response under dynamic loading

    International Nuclear Information System (INIS)

    Akram, T.; Memon, S.A.

    2008-01-01

    In design practice, dynamic structural analysis is carried out with base of structure considered as fixed; this means that foundation is placed on rock like soil material. While conducting this type of analyses the role of foundation and soil behaviour is totally neglected. The actions in members and loads transferred at foundation level obtained in this manner do not depict the true structural behaviour. FEM (Finite Element Methods) analysis where both superstructure and foundation soil are coupled together is quite complicated and expensive for design environments. A simplified model is required to depict dynamic response of structures with foundations based on flexible soils. The primary purpose of this research is to compare the superstructure dynamic responses of structural systems with fixed base to that of simple soil model base. The selected simple soil model is to be suitable for use in a design environment to give more realistic results. For this purpose building models are idealized with various heights and structural systems in both 2D (Two Dimensional) and 3D (Three Dimensional) space. These models are then provided with visco-elastic supports representing three soil bearing capacities and the analysis results are compared to that of fixed supports models. The results indicate that fixed support system underestimates natural time period of the structures. Dynamic behavior and force response of visco-elastic support is different from fixed support model. Fixed support models result in over designed base columns and under designed beams. (author)

  16. Simultaneous topology optimization of structures and supports

    DEFF Research Database (Denmark)

    Buhl, Thomas

    2002-01-01

    supported areas. The method is applied to compliance minimization and mechanism design. In the case of mechanism design, the large displacements of the mechanism are modelled using geometrically nonlinear FE-analysis. Examples with minimization of the compliance demonstrate the effects of using variable......The purpose of this paper is to demonstrate a method for and the benefits of simultaneously designing structure and support distribution using topology optimization. The support conditions are included in the topology optimization by introducing, a new set of design variables that represents...... cost of supports in a design domain. Other examples show that more efficient mechanisms are obtained by introducing the support conditions in the topology optimization problem....

  17. Structuring AHP-based maintenance policy selection

    NARCIS (Netherlands)

    Goossens, Adriaan; Basten, Robertus Johannes Ida; Hummel, J. Marjan; van der Wegen, Leonardus L.M.

    2015-01-01

    We aim to structure the maintenance policy selection process for ships, using the Analytic Hierarchy Process (AHP). Maintenance is an important contributor to reach the intended life-time of capital technical assets, and it is gaining increasing interest and relevance. A maintenance policy is a

  18. Alignment of the MSGC barrel support structure

    International Nuclear Information System (INIS)

    Kari, Tammi; Miikka, Kotamaki; Tommi, Vanhala; Antti, Onnela

    1999-01-01

    The MSGC barrel is a sub-part of the tracking system of the CMS experiment at the LHC. The mechanical support structure of the MSGC barrel consists of ladder-like support beams carrying the detector modules and of four disks supporting the ladders. The required alignment precision of the modules, a few tens of micrometers, is designed to be obtained by precise part manufacture and by careful measurement of the alignment during the assembly of the structure. In the paper the use of digital photogrammetry for the measurement of the alignment of the disks and for the structural verification is presented. Digital photogrammetry was chosen from a number of potential methods after a careful evaluation. The use of photogrammetry for the structural verification of a prototype is presented. The displacements were measured both of unloaded and loaded disk by using photogrammetry and linear displacement transducers for verification. The displacements obtained from the two measurement methods corresponded well, not only to each other, but also to the results given by finite element analysis. The structural verification will be done and the alignment procedure will be tested with a full-sized prototype of a half of the MSGC barrel. Preparations for the photogrammetry measurements are presented and the design of the required supplementary equipment is shown. (authors)

  19. Alignment of the MSGC barrel support structure

    Energy Technology Data Exchange (ETDEWEB)

    Kari, Tammi; Miikka, Kotamaki; Tommi, Vanhala [HIP, Helsinki Institute of Physics, CERN/EP, Geneva (Switzerland); Antti, Onnela [CERN, Conseil Europeen pour la recherche nucleaire, Laboratoire europeen pour la physique des particules, Geneve (Switzerland)

    1999-07-01

    The MSGC barrel is a sub-part of the tracking system of the CMS experiment at the LHC. The mechanical support structure of the MSGC barrel consists of ladder-like support beams carrying the detector modules and of four disks supporting the ladders. The required alignment precision of the modules, a few tens of micrometers, is designed to be obtained by precise part manufacture and by careful measurement of the alignment during the assembly of the structure. In the paper the use of digital photogrammetry for the measurement of the alignment of the disks and for the structural verification is presented. Digital photogrammetry was chosen from a number of potential methods after a careful evaluation. The use of photogrammetry for the structural verification of a prototype is presented. The displacements were measured both of unloaded and loaded disk by using photogrammetry and linear displacement transducers for verification. The displacements obtained from the two measurement methods corresponded well, not only to each other, but also to the results given by finite element analysis. The structural verification will be done and the alignment procedure will be tested with a full-sized prototype of a half of the MSGC barrel. Preparations for the photogrammetry measurements are presented and the design of the required supplementary equipment is shown. (authors)

  20. Community-oriented support and research structures

    Energy Technology Data Exchange (ETDEWEB)

    Attig, Norbert; Eickermann, Thomas; Gibbon, Paul; Lippert, Thomas, E-mail: th.lippert@fz-juelich.d [Institute for Advanced Simulation, Juelich Supercomputing Centre, Forschungszentrum Juelich, 52425 Juelich (Germany)

    2009-07-01

    Coordinated by the Partnership for Advanced Computing in Europe (PRACE) Europe is restructuring and strengthening its high-performance computing infrastructure with the aim to create a model HPC ecosystem. At the tip of the pyramid, up to six centres are envisaged that will operate systems of the highest performance class. The HPC Research Infrastructure (HPC-RI) will comprise European, national and regional centres. Science communities are integral partners, strong links will include Grid and Cloud users. The HPC-RI strives at providing scientists all over Europe, on the one hand, with unlimited and independent access to state-of-the-art computer resources in all performance classes and, on the other hand, with a world-class pan-European competence and support network. While the hardware-oriented buildup of the infrastructure is making progress, high-quality user support and software development in the upcoming era of unprecedented parallelism and exascale on the horizon have become the imminent challenges. This has been clearly recognized by the European Commission, who will issue calls for proposals to fund petascale software development in summer 2009. Although traditional support structures are well established in Europe's major supercomputing centres, it is questionable if these structures are able to meet the challenges of the future: in general, support structures are based on cross-disciplinary computer science and mathematics teams; disciplinary computational science support usually is given in an ad-hoc, project-oriented manner. In this paper, we describe our approach to establish a suitable support structure-Simulation Laboratories (SL). SLs are currently being established at the Juelich Supercomputing Centre of the Forschungszentrum Juelich (FZJ) and at the Steinbuch Centre for Computing (SCC) of the Karlsruhe Institute for Technology (KIT) in Germany. While SLs are community-oriented, i.e. each SL focusses on a specific community, they are

  1. Community-oriented support and research structures

    International Nuclear Information System (INIS)

    Attig, Norbert; Eickermann, Thomas; Gibbon, Paul; Lippert, Thomas

    2009-01-01

    Coordinated by the Partnership for Advanced Computing in Europe (PRACE) Europe is restructuring and strengthening its high-performance computing infrastructure with the aim to create a model HPC ecosystem. At the tip of the pyramid, up to six centres are envisaged that will operate systems of the highest performance class. The HPC Research Infrastructure (HPC-RI) will comprise European, national and regional centres. Science communities are integral partners, strong links will include Grid and Cloud users. The HPC-RI strives at providing scientists all over Europe, on the one hand, with unlimited and independent access to state-of-the-art computer resources in all performance classes and, on the other hand, with a world-class pan-European competence and support network. While the hardware-oriented buildup of the infrastructure is making progress, high-quality user support and software development in the upcoming era of unprecedented parallelism and exascale on the horizon have become the imminent challenges. This has been clearly recognized by the European Commission, who will issue calls for proposals to fund petascale software development in summer 2009. Although traditional support structures are well established in Europe's major supercomputing centres, it is questionable if these structures are able to meet the challenges of the future: in general, support structures are based on cross-disciplinary computer science and mathematics teams; disciplinary computational science support usually is given in an ad-hoc, project-oriented manner. In this paper, we describe our approach to establish a suitable support structure-Simulation Laboratories (SL). SLs are currently being established at the Juelich Supercomputing Centre of the Forschungszentrum Juelich (FZJ) and at the Steinbuch Centre for Computing (SCC) of the Karlsruhe Institute for Technology (KIT) in Germany. While SLs are community-oriented, i.e. each SL focusses on a specific community, they are structured

  2. Structural integrity of graphite core support structures of HTTR

    International Nuclear Information System (INIS)

    Inagaki, Yoshiyuki; Iyoku, Tatsuo; Toyota, Junji; Sato, Sadao; Shiozawa, Shusaku

    1990-02-01

    The graphite core support structures (GCSSs) of the HTTR (High Temperature Engineering Test Reactor) are an arrangement of graphite blocks and posts that support the core and provide a lower plenum and a hot-leg path for the primary coolant. The GCSSs are designed not to be replaced by new items during plant life time (about twenty years). To maintain structural integrity of the GCSSs, conservative design has been made sufficiently on the basis of structural tests. The present study confirmed that reactor safety was still maintained even if failure and destruction of the GCSSs is supposed to occur. The GCSSs are fabricated under strict quality control and the observation and surveillance programs are planed to examine the structual integrity of the GCSSs during an operation. This paper describes the concept of design and quality control and summarizes structural tests, observation and surveillance programs. (author)

  3. Direction selective structural-acoustic coupled radiator

    Science.gov (United States)

    Seo, Hee-Seon; Kim, Yang-Hann

    2005-04-01

    This paper presents a method of designing a structural-acoustic coupled radiator that can emit sound in the desired direction. The structural-acoustic coupled system is consisted of acoustic spaces and wall. The wall composes two plates and an opening, and the wall separates one space that is highly reverberant and the other that is unbounded without any reflection. An equation is developed that predicts energy distribution and energy flow in the two spaces separated by the wall, and its computational examples are presented including near field acoustic characteristics. To design the directional coupled radiator, Pareto optimization method is adapted. An objective is selected to maximize radiation power on a main axis and minimize a side lobe level and a subjective is selected direction of the main axis and dimensions of the walls geometry. Pressure and intensity distribution of the designed radiator is also presented.

  4. Selective optical transmission in anisotropic multilayers structure

    International Nuclear Information System (INIS)

    Ouchani, N.; Bria, D.; Nougaoui, A.; Merad, A.E.

    2007-08-01

    We developed a Green's function method to study theoretically a single-defect photonic crystal composed of anisotropic dielectric materials. This structure can trap light of a given frequency range and filter only a certain frequency light with a very high quality. It is shown that the defect modes appear as peaks in the transmission spectrum. Their intensities and frequency positions depend on the incidence angle and the orientation of the principal axes of layers consisting of the superlattice and the layer defect. Our structure offers a great variety of possibilities for creating and controlling the number and transmitted intensities of defect modes. It can be a good candidate for realizing a selective electromagnetic filter. In addition to this filtration process, the defective anisotropic photonic crystal can be used to switch the modes when appropriate geometry is selected. (author)

  5. Structural analysis of support structure for ITER vacuum vessel

    International Nuclear Information System (INIS)

    Takeda, Nobukazu; Ohmori, Junji; Nakahira, Masataka

    2004-12-01

    ITER vacuum vessel (VV) is a safety component confining radioactive materials such as tritium and activated dust. An independent VV support structure with multiple flexible plates located at the bottom of VV lower port is proposed. This independent concept has two advantages: (1) thermal load due to the temperature deference between VV and the lower temperature components such as TF coil becomes lower and (2) the other components such as TF coil is categorized as a non-safety component because of its independence from VV. Stress analyses have been performed to assess the integrity of the VV support structure using a precisely modeled VV structure. As a result, (1) the maximum displacement of the VV corresponding to the relative displacement between VV and TF coil is found to be 15 mm, much less than the current design value of 100 mm, and (2) the stresses of the whole VV system including VV support are estimated to be less than the allowable ones defined by ASME Section III Subsection NF, respectively. Based on these assessments, the feasibility of the proposed independent VV support has been verified as a VV support. (author)

  6. Optimum Tower Crane Selection and Supporting Design Management

    Directory of Open Access Journals (Sweden)

    Hyo Won Sohn

    2014-08-01

    Full Text Available To optimize tower crane selection and supporting design, lifting requirements (as well as stability should be examined, followed by a review of economic feasibility. However, construction engineers establish plans based on data provided by equipment suppliers since there are no tools with which to thoroughly examine a support design's suitability for various crane types, and such plans lack the necessary supporting data. In such cases it is impossible to optimize a tower crane selection to satisfy lifting requirements in terms of cost, and to perform lateral support and foundation design. Thus, this study is intended to develop an optimum tower crane selection and supporting design management method based on stability. All cases that are capable of generating an optimization of approximately 3,000 ˜ 15,000 times are calculated to identify the candidate cranes with minimized cost, which are examined. The optimization method developed in the study is expected to support engineers in determining the optimum lifting equipment management.

  7. Structural studies of supported tin catalysts

    Science.gov (United States)

    Nava, Noel; Viveros, Tomás

    1999-11-01

    Tin oxide was supported on aluminium oxide, titanium oxide, magnesium oxide and silicon oxide, and the resulting interactions between the components in the prepared samples and after reduction were characterized by Mössbauer spectroscopy. It was observed that in the oxide state, tin is present as SnO2 on alumina, magnesia and silica, but on titania tin occupies Ti sites in the structure. After hydrogen treatment at high temperatures, tin is reduced from Sn(4) to Sn(2) on alumina and titania; it is reduced from Sn(4) to Sn(0) on silica, and is practically not reduced on magnesia. These results reveal the degree of interaction between tin and the different supports studied.

  8. Structural studies of supported tin catalysts

    International Nuclear Information System (INIS)

    Nava, Noel; Viveros, Tomas

    1999-01-01

    Tin oxide was supported on aluminium oxide, titanium oxide, magnesium oxide and silicon oxide, and the resulting interactions between the components in the prepared samples and after reduction were characterized by Moessbauer spectroscopy. It was observed that in the oxide state, tin is present as SnO 2 on alumina, magnesia and silica, but on titania tin occupies Ti sites in the structure. After hydrogen treatment at high temperatures, tin is reduced from Sn(4) to Sn(2) on alumina and titania; it is reduced from Sn(4) to Sn(0) on silica, and is practically not reduced on magnesia. These results reveal the degree of interaction between tin and the different supports studied

  9. Frequency Selective Surface for Structural Health Monitoring

    Science.gov (United States)

    Norlyana Azemi, Saidatul; Mustaffa, Farzana Hazira Wan; Faizal Jamlos, Mohd; Abdullah Al-Hadi, Azremi; Soh, Ping Jack

    2018-03-01

    Structural health monitoring (SHM) technologies have attained attention to monitor civil structures. SHM sensor systems have been used in various civil structures such as bridges, buildings, tunnels and so on. However the previous sensor for SHM is wired and encounter with problem to cover large areas. Therefore, wireless sensor was introduced for SHM to reduce network connecting problem. Wireless sensors for Structural Health monitoring are new technology and have many advantages to overcome the drawback of conventional and wired sensor. This project proposed passive wireless SHM sensor using frequency selective surface (FSS) as an alternative to conventional sensors. The electromagnetic wave characteristic of FSS will change by geometrical changes of FSS due to mechanical strain or structural failure. The changes feature is used as a sensing function without any connecting wires. Two type of design which are circular ring and square loop along with the transmission and reflection characteristics of SHM using FSS were discussed in this project. A simulation process has shown that incident angle characteristics can be use as a data for SHM application.

  10. Support for argument structures review and assessment

    International Nuclear Information System (INIS)

    Cyra, Lukasz; Gorski, Janusz

    2011-01-01

    Argument structures are commonly used to develop and present cases for safety, security and for other properties of systems. Such structures tend to grow excessively, which causes problems with their review and assessment. Two issues are of particular interest: (1) systematic and explicit assessment of the compelling power of an argument, and (2) communication of the result of such an assessment to relevant recipients. The paper presents a solution to these problems. The method of Visual Assessment of Arguments (VAA), being this solution, is based on the Dempster-Shafer theory of evidence applied to the assessment of the strength of arguments, and a visual mechanism of issuing and presenting assessments, supported by the so-called opinion triangle. In the paper we explain theoretical grounding for the method and provide guidance on its application. The results of some validation experiments are also presented.

  11. Liquid metal systems development: reactor vessel support structure evaluation

    International Nuclear Information System (INIS)

    McEdwards, J.A.

    1981-01-01

    Results of an evaluation of support structures for the reactor vessel are reported. The U ring, box ring, integral ring, tee ring and tangential beam supports were investigated. The U ring is the recommended vessel support structure configuration

  12. Dynamic structural disorder in supported nanoscale catalysts

    International Nuclear Information System (INIS)

    Rehr, J. J.; Vila, F. D.

    2014-01-01

    We investigate the origin and physical effects of “dynamic structural disorder” (DSD) in supported nano-scale catalysts. DSD refers to the intrinsic fluctuating, inhomogeneous structure of such nano-scale systems. In contrast to bulk materials, nano-scale systems exhibit substantial fluctuations in structure, charge, temperature, and other quantities, as well as large surface effects. The DSD is driven largely by the stochastic librational motion of the center of mass and fluxional bonding at the nanoparticle surface due to thermal coupling with the substrate. Our approach for calculating and understanding DSD is based on a combination of real-time density functional theory/molecular dynamics simulations, transient coupled-oscillator models, and statistical mechanics. This approach treats thermal and dynamic effects over multiple time-scales, and includes bond-stretching and -bending vibrations, and transient tethering to the substrate at longer ps time-scales. Potential effects on the catalytic properties of these clusters are briefly explored. Model calculations of molecule-cluster interactions and molecular dissociation reaction paths are presented in which the reactant molecules are adsorbed on the surface of dynamically sampled clusters. This model suggests that DSD can affect both the prefactors and distribution of energy barriers in reaction rates, and thus can significantly affect catalytic activity at the nano-scale

  13. Dynamic structural disorder in supported nanoscale catalysts

    Energy Technology Data Exchange (ETDEWEB)

    Rehr, J. J.; Vila, F. D. [Department of Physics, University of Washington, Seattle, Washington 98195 (United States)

    2014-04-07

    We investigate the origin and physical effects of “dynamic structural disorder” (DSD) in supported nano-scale catalysts. DSD refers to the intrinsic fluctuating, inhomogeneous structure of such nano-scale systems. In contrast to bulk materials, nano-scale systems exhibit substantial fluctuations in structure, charge, temperature, and other quantities, as well as large surface effects. The DSD is driven largely by the stochastic librational motion of the center of mass and fluxional bonding at the nanoparticle surface due to thermal coupling with the substrate. Our approach for calculating and understanding DSD is based on a combination of real-time density functional theory/molecular dynamics simulations, transient coupled-oscillator models, and statistical mechanics. This approach treats thermal and dynamic effects over multiple time-scales, and includes bond-stretching and -bending vibrations, and transient tethering to the substrate at longer ps time-scales. Potential effects on the catalytic properties of these clusters are briefly explored. Model calculations of molecule-cluster interactions and molecular dissociation reaction paths are presented in which the reactant molecules are adsorbed on the surface of dynamically sampled clusters. This model suggests that DSD can affect both the prefactors and distribution of energy barriers in reaction rates, and thus can significantly affect catalytic activity at the nano-scale.

  14. Influence of Support Configurations on the Characteristics of Selective Laser-Melted Inconel 718

    Science.gov (United States)

    Nadammal, Naresh; Kromm, Arne; Saliwan-Neumann, Romeo; Farahbod, Lena; Haberland, Christoph; Portella, Pedro Dolabella

    2018-03-01

    Samples fabricated using two different support configurations by following identical scan strategies during selective laser melting of superalloy Inconel 718 were characterized in this study. Characterization methods included optical microscopy, electron back-scattered diffraction and x-ray diffraction residual stress measurement. For the scan strategy considered, microstructure and residual stress development in the samples were influenced by the support structures. However, crystallographic texture intensity and the texture components formed within the core part of the samples were almost independent of the support. The formation of finer grains closer to the support as well as within the columnar grain boundaries resulted in randomization and texture intensity reduction by nearly half for the sample built on a lattice support. Heat transfer rates dictated by the support configurations in addition to the scan strategy influenced the microstructure and residual stress development in selective laser-melted Inconel 718 samples.

  15. NRC safety research in support of regulation. Selected highlights

    International Nuclear Information System (INIS)

    1986-05-01

    The report presents selected highlights of how research has contributed to the regulatory effort. It explains the research role of the NRC and nuclear safety research contributions in the areas of: pressure vessel integrity, piping, small- and large-break loss-of-coolant accidents, hydrogen and containment, source term analysis, seismic hazards and high-level waste management. The report also provides a summary of current and future research directions in support of regulation

  16. Road Network Selection Based on Road Hierarchical Structure Control

    Directory of Open Access Journals (Sweden)

    HE Haiwei

    2015-04-01

    Full Text Available A new road network selection method based on hierarchical structure is studied. Firstly, road network is built as strokes which are then classified into hierarchical collections according to the criteria of betweenness centrality value (BC value. Secondly, the hierarchical structure of the strokes is enhanced using structural characteristic identification technique. Thirdly, the importance calculation model was established according to the relationships among the hierarchical structure of the strokes. Finally, the importance values of strokes are got supported with the model's hierarchical calculation, and with which the road network is selected. Tests are done to verify the advantage of this method by comparing it with other common stroke-oriented methods using three kinds of typical road network data. Comparision of the results show that this method had few need to semantic data, and could eliminate the negative influence of edge strokes caused by the criteria of BC value well. So, it is better to maintain the global hierarchical structure of road network, and suitable to meet with the selection of various kinds of road network at the same time.

  17. System for selecting relevant information for decision support.

    Science.gov (United States)

    Kalina, Jan; Seidl, Libor; Zvára, Karel; Grünfeldová, Hana; Slovák, Dalibor; Zvárová, Jana

    2013-01-01

    We implemented a prototype of a decision support system called SIR which has a form of a web-based classification service for diagnostic decision support. The system has the ability to select the most relevant variables and to learn a classification rule, which is guaranteed to be suitable also for high-dimensional measurements. The classification system can be useful for clinicians in primary care to support their decision-making tasks with relevant information extracted from any available clinical study. The implemented prototype was tested on a sample of patients in a cardiological study and performs an information extraction from a high-dimensional set containing both clinical and gene expression data.

  18. Selective oxidation of propylene to acrolein by silica-supported bismuth molybdate catalysts

    DEFF Research Database (Denmark)

    Duc, Duc Truong; Ha, Hanh Nguyen; Fehrmann, Rasmus

    2011-01-01

    Silica-supported bismuth molybdate catalysts have been prepared by impregnation, structurally characterized and examined as improved catalysts for the selective oxidation of propylene to acrolein. Catalysts with a wide range of loadings (from 10 to 90 wt%) of beta bismuth molybdate (β-Bi2Mo2O9) w...

  19. Design of a far infrared interferometer diagnostic support structure

    International Nuclear Information System (INIS)

    Brooksby, C.A.; Rice, B.W.; Peebles, W.A.

    1987-10-01

    The Far Infrared Interferometer (FIR) diagnostic will operate in the 119 to 400 micron range to measure the plasma electron density on the Microwave Tokamak Experiment (MTX) being set up at LLNL. This diagnostic is a multi-channel system which incorporates a long elliptically shaped beam that passes through the plasma and is imaged onto an array of 14 detectors that are located on a table above the machine. The reference beam is brought around the machine and mixed with the plasma beam onto the detectors. The density is measured by a phase shift between these beams and is, therefore, very sensitive to path length changes between the two beam paths due to motion of the support structure. The design goal for allowable phase shifts caused by changes in the path length due to structure movement is 1/50th of a wavelength (2.4 to 8 microns). The structure needs to maintain this stability during the 0.5 second plasma shot. The structure is approximately 5 meters tall to support the optics table above the machine. In order to reduce the structure motion to the required level the forces acting on it were evaluated. The forces evaluated were eddy currents from the pulsed electromagnetic fields, the ambient ground motion, and the floor movement as the magnets are pulsed. The designs for similar diagnostic interferometers on other tokamaks were also reviewed to evaluate the forces and motions that might cause such small deflections in the support structure. Our structure is somewhat unique in that it is designed for operation in relatively large pulsed magnetic fields (100 to 7000 gauss) arising from the air core transformer of MTX. The design chosen incorporates a very rigid structure with high resistive and non-conductive materials. The choice of materials selected is discussed with reference to their response to expected forces. 14 refs., 10 figs

  20. Relating performance of thin-film composite forward osmosis membranes to support layer formation and structure

    KAUST Repository

    Tiraferri, Alberto; Yip, Ngai Yin; Phillip, William A.; Schiffman, Jessica D.; Elimelech, Menachem

    2011-01-01

    the technology to the point that it is commercially viable. Here, a systematic investigation of the influence of thin-film composite membrane support layer structure on forward osmosis performance is conducted. The membranes consist of a selective polyamide

  1. Structure-specific selection of earthquake ground motions for the reliable design and assessment of structures

    DEFF Research Database (Denmark)

    Katsanos, E. I.; Sextos, A. G.

    2018-01-01

    A decision support process is presented to accommodate selecting and scaling of earthquake motions as required for the time domain analysis of structures. Code-compatible suites of seismic motions are provided being, at the same time, prequalified through a multi-criterion approach to induce...... was subjected to numerous suites of motions that were highly ranked according to both the proposed approach (δsv–sc) and the conventional one (δconv), that is commonly used for earthquake records selection and scaling. The findings from numerous linear response history analyses reveal the superiority...

  2. Artificial Intelligence Support for Landing Site Selection on Mars

    Science.gov (United States)

    Rongier, G.; Pankratius, V.

    2017-12-01

    Mars is a key target for planetary exploration; a better understanding of its evolution and habitability requires roving in situ. Landing site selection is becoming more challenging for scientists as new instruments generate higher data volumes. The involved engineering and scientific constraints make site selection and the anticipation of possible onsite actions into a complex optimization problem: there may be multiple acceptable solutions depending on various goals and assumptions. Solutions must also account for missing data, errors, and potential biases. To address these problems, we propose an AI-informed decision support system that allows scientists, mission designers, engineers, and committees to explore alternative site selection choices based on data. In particular, we demonstrate first results of an exploratory case study using fuzzy logic and a simulation of a rover's mobility map based on the fast marching algorithm. Our system computes favorability maps of the entire planet to facilitate landing site selection and allows a definition of different configurations for rovers, science target priorities, landing ellipses, and other constraints. For a rover similar to NASA's Mars 2020 rover, we present results in form of a site favorability map as well as four derived exploration scenarios that depend on different prioritized scientific targets, all visualizing inherent tradeoffs. Our method uses the NASA PDS Geosciences Node and the NASA/ICA Integrated Database of Planetary Features. Under common assumptions, the data products reveal Eastern Margaritifer Terra and Meridiani Planum to be the most favorable sites due to a high concentration of scientific targets and a flat, easily navigable surface. Our method also allows mission designers to investigate which constraints have the highest impact on the mission exploration potential and to change parameter ranges. Increasing the elevation limit for landing, for example, provides access to many additional

  3. Selection of a tool to support decision making for site selection for high level waste - 15010

    International Nuclear Information System (INIS)

    Madeira, J.G.; Alvim, A.C.M.; Martins, V.B.; Monteiro, N.A.

    2015-01-01

    The aim of this paper is to create a panel comparing some of the key decision-making support tools used in situations with the characteristics of the problem of selecting suitable areas for constructing a final deep geologic repository. The tools presented in this work are also well-known and with easy implementation. The decision making process in issues of this kind is, in general, complex due to its multi-criteria nature and the conflicting opinions of various of stakeholders. Thus a comprehensive study was performed with the literature on this subject, specifically documents of the International Atomic Energy Agency - IAEA, regarding the importance of the criteria involved in the decision making process. Therefore, we highlighted 6 judgments attributes for selecting an adequate support tool: -) transparency and reliability, -) subjectivity, -) updating and adapting, -) multi-criteria analysis, -) ease of deployment, and -) application time. We have selected the following key decision-making support tools: AHP, Delphi, Brainstorm, Nominal Group Technique, and AHP-Delphi. Finally, the AHP-Delphi method has demonstrated to be more appropriate for managing the inherent multiple attributes to the problem proposed

  4. Response of two structures supported on common foundation

    International Nuclear Information System (INIS)

    Joshi, M.H.; Kulkarni, M.R.; Subramanian, K.V.; Palekar, S.M.; Warudkar, A.S.

    1995-01-01

    The present paper describes a parametric study of structure-structure interaction. The parameter's selected are stiffness and mass of the structures and stiffness of foundation medium. The paper concludes that in case of weak soils structures do interact through the common foundation and for rock-like foundation conditions there is no interaction between the structures. (author). 1 fig., 6 tabs

  5. Selective Mutism Questionnaire: Measurement Structure and Validity

    Science.gov (United States)

    Letamendi, Andrea M.; Chavira, Denise A.; Hitchcock, Carla A.; Roesch, Scott C.; Shipon-Blum, Elisa; Stein, Murray B.

    2008-01-01

    The psychometric properties of the Selective Mutism Questionnaire (SMQ) are evaluated using a clinical sample of children with selective mutism (SM). The study shows that SMQ is useful in determining the severity of a child's nonspeaking behaviors, the scope of these behaviors and necessary follow up assessment.

  6. The Selective Mutism Questionnaire: Measurement Structure and Validity

    Science.gov (United States)

    Letamendi, Andrea M.; Chavira, Denise A.; Hitchcock, Carla A.; Roesch, Scott C.; Shipon-Blum, Elisa; Stein, Murray B.; Roesch, Scott C.

    2010-01-01

    Objective To evaluate the factor structure, reliability, and validity of the 17-item Selective Mutism Questionnaire. Method Diagnostic interviews were administered via telephone to 102 parents of children identified with selective mutism (SM) and 43 parents of children without SM from varying U.S. geographic regions. Children were between the ages of 3 and 11 inclusive and comprised 58% girls and 42% boys. SM diagnoses were determined using the Anxiety Disorders Interview Schedule for Children - Parent Version (ADIS-C/P); SM severity was assessed using the 17-item Selective Mutism Questionnaire (SMQ); and behavioral and affective symptoms were assessed using the Child Behavior Checklist (CBCL). An exploratory factor analysis (EFA) was conducted to investigate the dimensionality of the SMQ and a modified parallel analysis procedure was used to confirm EFA results. Internal consistency, construct validity, and incremental validity were also examined. Results The EFA yielded a 13-item solution consisting of three factors: a) Social Situations Outside of School, b) School Situations, and c) Home and Family Situations. Internal consistency of SMQ factors and total scale ranged from moderate to high. Convergent and incremental validity were also well supported. Conclusions Measure structure findings are consistent with the 3-factor solution found in a previous psychometric evaluation of the SMQ. Results also suggest that the SMQ provides useful and unique information in the prediction of SM phenomenon beyond other child anxiety measures. PMID:18698268

  7. Parameters selection in gene selection using Gaussian kernel support vector machines by genetic algorithm

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    In microarray-based cancer classification, gene selection is an important issue owing to the large number of variables and small number of samples as well as its non-linearity. It is difficult to get satisfying results by using conventional linear statistical methods. Recursive feature elimination based on support vector machine (SVM RFE) is an effective algorithm for gene selection and cancer classification, which are integrated into a consistent framework. In this paper, we propose a new method to select parameters of the aforementioned algorithm implemented with Gaussian kernel SVMs as better alternatives to the common practice of selecting the apparently best parameters by using a genetic algorithm to search for a couple of optimal parameter. Fast implementation issues for this method are also discussed for pragmatic reasons. The proposed method was tested on two representative hereditary breast cancer and acute leukaemia datasets. The experimental results indicate that the proposed method performs well in selecting genes and achieves high classification accuracies with these genes.

  8. A support structure for biomimetic applications

    DEFF Research Database (Denmark)

    Vogel, Jörg; Perry, Mark; Hansen, Jesper Søndergaard

    2009-01-01

    Water filtration on the basis of aquaporin molecules incorporated in an artificial lipid bilayer requires a microporous support membrane. We describe a new microfabrication method based on CO2-laser ablation to generate support membranes with homogeneous apertures ranging from 300 mu m down to 84...... to visualize and analyse these bulges. The overall area covered so far has been 4 cm(2) but upscaling to larger footprints, e. g. square metres, is currently being investigated....

  9. Structural Analysis of Cabinet Support under Static and Seismic Loads

    International Nuclear Information System (INIS)

    Jung, Kwangsub; Lee, Sangjin; Oh, Jinho

    2014-01-01

    The cabinet support consists of frames including steel channels and steel square tubes. Four tap holes for screw bolts are located on the support frame of a steel channel to fix the cabinet on the support. The channels and square tubes are assembled by welded joints. The cabinet supports are installed on the outer walls of the reactor concrete island. The KEPIC code, MNF, is used for the design of the cabinet support. In this work, the structural integrity of the cabinet support is analyzed under consideration of static and seismic loads. A 3-D finite element model of the cabinet support was developed. The structural integrity of the cabinet support under postulated service loading conditions was evaluated through a static analysis, modal analysis, and response spectrum analysis. From the structural analysis results, it was concluded that the structural integrity of the cabinet support is guaranteed

  10. Supported polytertiary amines: highly efficient and selective SO2 adsorbents.

    Science.gov (United States)

    Tailor, Ritesh; Abboud, Mohamed; Sayari, Abdelhamid

    2014-01-01

    Tertiary amine containing poly(propyleneimine) second (G2) and third (G3) generation dendrimers as well as polyethyleneimine (PEI) were developed for the selective removal of SO2. N-Alkylation of primary and secondary amines into tertiary amines was confirmed by FTIR and NMR analysis. Such modified polyamines were impregnated on two nanoporous supports, namely, SBA-15PL silica with platelet morphology and ethanol-extracted pore-expanded MCM-41 (PME) composite. In the presence of 0.1% SO2/N2 at 23 °C, the uptake of modified PEI, G2, and G3 supported on SBA-15PL was 2.07, 2.35, and 1.71 mmol/g, respectively; corresponding to SO2/N ratios of 0.22, 0.4, and 0.3. Under the same conditions, the SO2 adsorption capacity of PME-supported modified PEI and G3 was significantly higher, reaching 4.68 and 4.34 mmol/g, corresponding to SO2/N ratios of 0.41 and 0.82, respectively. The working SO2 adsorption capacity decreased with increasing temperature, reflecting the exothermic nature of the process. The adsorption capacity of these materials was enhanced dramatically in the presence of humidity in the gas mixture. FTIR data before SO2 adsorption and after adsorption and regeneration did not indicate any change in the materials. Nonetheless, the SO2 working capacity decreased in consecutive adsorption/regeneration cycles due to evaporation of impregnated polyamines, rather than actual deactivation. FTIR and (13)C and (15)N CP-MAS NMR of fresh and SO2 adsorbed modified G3 on PME confirmed the formation of a complexation adduct.

  11. The Structure and Validity of the Multidimensional Social Support Questionnaire

    Science.gov (United States)

    Hardesty, Patrick H.; Richardson, George B.

    2012-01-01

    The factor structure and concurrent validity of the Multidimensional Social Support Questionnaire, a brief measure of perceived social support for use with adolescents, was examined. Findings suggest that four dimensions of perceived social support may yield more information than assessments of the unitary construct of support. (Contains 8 tables…

  12. Probing of RNA structures in a positive sense RNA virus reveals selection pressures for structural elements

    Science.gov (United States)

    Watters, Kyle E; Choudhary, Krishna; Aviran, Sharon; Perry, Keith L

    2018-01-01

    Abstract In single stranded (+)-sense RNA viruses, RNA structural elements (SEs) play essential roles in the infection process from replication to encapsidation. Using selective 2′-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq) and covariation analysis, we explore the structural features of the third genome segment of cucumber mosaic virus (CMV), RNA3 (2216 nt), both in vitro and in plant cell lysates. Comparing SHAPE-Seq and covariation analysis results revealed multiple SEs in the coat protein open reading frame and 3′ untranslated region. Four of these SEs were mutated and serially passaged in Nicotiana tabacum plants to identify biologically selected changes to the original mutated sequences. After passaging, loop mutants showed partial reversion to their wild-type sequence and SEs that were structurally disrupted by mutations were restored to wild-type-like structures via synonymous mutations in planta. These results support the existence and selection of virus open reading frame SEs in the host organism and provide a framework for further studies on the role of RNA structure in viral infection. Additionally, this work demonstrates the applicability of high-throughput chemical probing in plant cell lysates and presents a new method for calculating SHAPE reactivities from overlapping reverse transcriptase priming sites. PMID:29294088

  13. Structural Integrity Evaluation of the KALIMER-600 Reactor Core Support Structure

    International Nuclear Information System (INIS)

    Park, Chang Gyu; Kim, Jong Bum; Lee, Jae Han

    2005-01-01

    KALIMER-600(Korea Advanced LIquid MEtal Reactor, 600MWe) is a pool type sodium-cooled liquid metal reactor. Since the normal operating temperature of KALIMER-600 is 545 .deg. C, the reactor structures in the hot pool region are designed and evaluated according to the elevated temperature design rules such as the ASME Boiler and Pressure Vessel Code Section III, Subsection NH. Since the core support structure of KALIMER-600 is in the cold pool region under 400 .deg. C, a high temperature inelastic behavior is not expected. Thus the stress and fatigue limits are the main concerns to assure the structural design integrity following the ASME Subsection NG. In this paper, the evaluations of the stress and fatigue damage for the core support structure of KALIMER-600 are carrried out in the case of a normal operation condition using the rules of ASME Subsection NG. To obtain the stress values, a heat transfer analysis and a stress analysis under a combined loading condition are performed. From the stress distribution results, the critical sections are selected and the stress and fatigue limits are evaluated for the selected regions

  14. Future Contract Selection by Term Structure Analysis

    Directory of Open Access Journals (Sweden)

    Vasco Grossmann

    2017-07-01

    Full Text Available In futures markets, a single asset is generally represented by several contracts with different maturities. The selection of specific contracts is an inevitable task that also creates new opportunities, especially in terms of speculative trading. Evaluating immediate and upcoming trading costs for all considered contracts might lead to a significantly improved performance. Among that, even possible market inefficiencies might be taken into consideration. This research introduces and evaluates a new algorithm for the contract selection. The results are benchmarked and compared with established methods using a Monte Carlo simulation on different commodity and index futures.

  15. Geographical data structures supporting regional analysis

    International Nuclear Information System (INIS)

    Edwards, R.G.; Durfee, R.C.

    1978-01-01

    In recent years the computer has become a valuable aid in solving regional environmental problems. Over a hundred different geographic information systems have been developed to digitize, store, analyze, and display spatially distributed data. One important aspect of these systems is the data structure (e.g. grids, polygons, segments) used to model the environment being studied. This paper presents eight common geographic data structures and their use in studies of coal resources, power plant siting, population distributions, LANDSAT imagery analysis, and landuse analysis

  16. A support structure for biomimetic applications

    International Nuclear Information System (INIS)

    Vogel, J; Perry, M; Hansen, J S; Bolinger, P-Y; Nielsen, C H; Geschke, O

    2009-01-01

    Water filtration on the basis of aquaporin molecules incorporated in an artificial lipid bilayer requires a microporous support membrane. We describe a new microfabrication method based on CO 2 -laser ablation to generate support membranes with homogeneous apertures ranging from 300 µm down to 84 µm in diameter. They are arranged in arrays with the densest packaging having a perforation level of up to 60%. The apertures are surrounded by a smooth bulge that is formed by melted material ejected from the aperture during laser ablation. Polydimethylsiloxane (PDMS) replicas were used to visualize and analyse these bulges. The overall area covered so far has been 4 cm 2 but upscaling to larger footprints, e.g. square metres, is currently being investigated

  17. ESF GROUND SUPPORT - STRUCTURAL STEEL ANALYSIS

    Energy Technology Data Exchange (ETDEWEB)

    T. Misiak

    1996-06-26

    The purpose and objective of this analysis are to expand the level of detail and confirm member sizes for steel sets included in the Ground Support Design Analysis, Reference 5.20. This analysis also provides bounding values and details and defines critical design attributes for alternative configurations of the steel set. One possible configuration for the steel set is presented. This analysis covers the steel set design for the Exploratory Studies Facility (ESF) entire Main Loop 25-foot diameter tunnel.

  18. Support structure for reactor core constituent element

    International Nuclear Information System (INIS)

    Aida, Yasuhiko.

    1993-01-01

    A connection pipe having an entrance nozzle inserted therein as a reactor core constituent element is protruded above the upper surface of a reactor core support plate. A through hole is disposed to the protruding portion of the connection pipe. The through hole and a through hole disposed to the reactor core support plate are connected by a communication pipe. A shear rod is disposed in a horizontal portion at the inside of the communication pipe and is supported by a spring horizontally movably. Further, a groove is disposed at a position of the entrance nozzle opposing to the shear rod. The shear rod is urged out of the communication pipe by the pressure of the high pressure plenum and the top end portion of the shear rod is inserted to the groove of the entrance nozzle during operation. Accordingly, the shear rod is positioned in a state where it is extended from the through hole of the communication pipe to the groove of the entrance nozzle. This can mechanically constrain the rising of the reactor core constituent elements by the shear rod upon occurrence of earthquakes. (I.N.)

  19. Self-centering connections for traffic sign supporting structures.

    Science.gov (United States)

    2015-03-01

    Steel structures supporting traffic sign panels are designed as intended to dissipate energy by : yielding structural members during severe wind loading (ex. strong hurricanes). Yielding results : in inelastic deformations, which are permanent damage...

  20. Structural Implications for Selective Targeting of PARPs.

    Science.gov (United States)

    Steffen, Jamin D; Brody, Jonathan R; Armen, Roger S; Pascal, John M

    2013-12-20

    Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that use NAD(+) as a substrate to synthesize polymers of ADP-ribose (PAR) as post-translational modifications of proteins. PARPs have important cellular roles that include preserving genomic integrity, telomere maintenance, transcriptional regulation, and cell fate determination. The diverse biological roles of PARPs have made them attractive therapeutic targets, which have fueled the pursuit of small molecule PARP inhibitors. The design of PARP inhibitors has matured over the past several years resulting in several lead candidates in clinical trials. PARP inhibitors are mainly used in clinical trials to treat cancer, particularly as sensitizing agents in combination with traditional chemotherapy to reduce side effects. An exciting aspect of PARP inhibitors is that they are also used to selectivity kill tumors with deficiencies in DNA repair proteins (e.g., BRCA1/2) through an approach termed "synthetic lethality." In the midst of the tremendous efforts that have brought PARP inhibitors to the forefront of modern chemotherapy, most clinically used PARP inhibitors bind to conserved regions that permits cross-selectivity with other PARPs containing homologous catalytic domains. Thus, the differences between therapeutic effects and adverse effects stemming from pan-PARP inhibition compared to selective inhibition are not well understood. In this review, we discuss current literature that has found ways to gain selectivity for one PARP over another. We furthermore provide insights into targeting other domains that make up PARPs, and how new classes of drugs that target these domains could provide a high degree of selectivity by affecting specific cellular functions. A clear understanding of the inhibition profiles of PARP inhibitors will not only enhance our understanding of the biology of individual PARPs, but may provide improved therapeutic options for patients.

  1. Selected topic in nuclear structure. V. 1

    International Nuclear Information System (INIS)

    Broda, R.; Stachura, Z.; Styczen, J.

    1985-01-01

    A report of recent experiments performed in different laboratories and a review of fundamental problems of nuclear physics connected with study of nuclear structure, that had just been solved are presented. The proceedings contain 33 articles. (M.F.-W.)

  2. The development of the design method of nuclear piping system supported by elasto-plastic support structures (Part 1)

    International Nuclear Information System (INIS)

    Endo, R.; Murota, M.; Kawahata, J.-I.; Sato, T.; Mekomoto, Y.; Takayama, Y.; Kobayashi, H.; Hirose, J.

    1993-01-01

    The conventional aseismic design method of nuclear piping system is very conservative because of the accumulation of various safety factors in the design process, and nuclear piping systems are thought to have a large safety margin. Considering this situation, we promoted research to further rationalize nuclear power plants by reducing the amount of support structures and reducing the piping seismic response through vibration energy absorption resulting from the elasto-plastic behavior of piping support structures. The research has the following three stages. In the first stage, we select conventional piping support structures in Japanese light-water reactors that exhibit elasto-plastic behavior, and study the displacement dependency and the vibration frequency dependency on the stiffness and the energy absorption by testing their model. In the second stage, we make a piping test model with support structures whose characteristics have already been obtained, and perform vibration tests on a shaking table. In this way, we analyze the piping vibration characteristics by sinusoidal wave sweep tests and the piping response characteristics by seismic wave vibration tests, when the support structures are in an elasto-plastic condition. In the third stage, a general method is developed to evaluate the characteristics of the support structures obtained in the tests and it is applied to the evaluation of the characteristics of general support structures. A simplified analysis method is developed to evaluate the piping seismic response using the piping model test result. To expand the results mentioned above, we are developing a seismic design method of piping systems that allows support structures to have elasto-plastic behaviour. This paper reports the results of experiments conducted under the joint research program of Japanese electric power companies with support elements in the first stage and those with piping models in the second stage

  3. Organizational structure features supporting knowledge management processes

    OpenAIRE

    Claver-Cortés, Enrique; Zaragoza Sáez, Patrocinio del Carmen; Pertusa-Ortega, Eva

    2007-01-01

    Purpose – The idea that knowledge management can be a potential source of competitive advantage has gained strength in the last few years. However, a number of business actions are needed to generate an appropriate environment and infrastructure for knowledge creation, transfer and application. Among these actions there stands out the design of an organizational structure, the link of which with knowledge management is the main concern here. More specifically, the present paper has as its aim...

  4. Auto type-selection of constant supporting in nuclear power stations

    International Nuclear Information System (INIS)

    Liu Hu; Wang Fujun; Liu Wei; Li Zhaoqing

    2013-01-01

    To solve the type-selection of constant supporting in nuclear power stations, combining the characteristics of constant supporting which can adjust in the certain scope and the rules of load-displacement, the requirements and process for the type-selection of constant supporting is proposed, and the process of type-selection is optimized by Visual Basic. After inputting of the known parameters, the process can automatically select the most economical and reasonable constant supporting by array and function. (authors)

  5. SADA: Ecological Risk Based Decision Support System for Selective Remediation

    Science.gov (United States)

    Spatial Analysis and Decision Assistance (SADA) is freeware that implements terrestrial ecological risk assessment and yields a selective remediation design using its integral geographical information system, based on ecological and risk assessment inputs. Selective remediation ...

  6. Selection of power market structure using the analytic hierarchy process

    International Nuclear Information System (INIS)

    Subhes Bhattacharyya; Prasanta Kumar Dey

    2003-01-01

    Selection of a power market structure from the available alternatives is an important activity within an overall power sector reform program. The evaluation criteria for selection are both subjective as well as objective in nature and the selection of alternatives is characterised by their conflicting nature. This study demonstrates a methodology for power market structure selection using the analytic hierarchy process, a multiple attribute decision- making technique, to model the selection methodology with the active participation of relevant stakeholders in a workshop environment. The methodology is applied to a hypothetical case of a State Electricity Board reform in India. (author)

  7. NSF tandem stack support structure deflection characteristics

    International Nuclear Information System (INIS)

    Cook, J.

    1979-12-01

    Results are reported of load tests carried out on the glass legs of the insulating stack of the 30 MV tandem Van de Graaff accelerator now under construction at Daresbury Laboratory. The tests to investigate the vulnerability of the legs when subjected to tensile stresses were designed to; establish the angle of rotation of the pads from which the stresses in the glass legs may be calculated, proof-test the structure and at the same time reveal any asymmetry in pad rotations or deflections, and to confirm the validity of the computer design analysis. (UK)

  8. Structuring supplemental materials in support of reproducibility.

    Science.gov (United States)

    Greenbaum, Dov; Rozowsky, Joel; Stodden, Victoria; Gerstein, Mark

    2017-04-05

    Supplements are increasingly important to the scientific record, particularly in genomics. However, they are often underutilized. Optimally, supplements should make results findable, accessible, interoperable, and reusable (i.e., "FAIR"). Moreover, properly off-loading to them the data and detail in a paper could make the main text more readable. We propose a hierarchical organization for supplements, with some parts paralleling and "shadowing" the main text and other elements branching off from it, and we suggest a specific formatting to make this structure explicit. Furthermore, sections of the supplement could be presented in multiple scientific "dialects", including machine-readable and lay-friendly formats.

  9. Modelling verb selection within argument structure constructions

    NARCIS (Netherlands)

    Matusevych, Yevgen; Alishahi, Afra; Backus, Albert

    2017-01-01

    This article looks into the nature of cognitive associations between verbs and argument structure constructions (ASCs). Existing research has shown that distributional and semantic factors affect speakers' choice of verbs in ASCs. A formal account of this theory has been proposed by Ellis,

  10. Animal behaviour and algal camouflage jointly structure predation and selection.

    Science.gov (United States)

    Start, Denon

    2018-05-01

    Trait variation can structure interactions between individuals, thus shaping selection. Although antipredator strategies are an important component of many aquatic systems, how multiple antipredator traits interact to influence consumption and selection remains contentious. Here, I use a common larval dragonfly (Epitheca canis) and its predator (Anax junius) to test for the joint effects of activity rate and algal camouflage on predation and survival selection. I found that active and poorly camouflaged Epitheca were more likely to be consumed, and thus, survival selection favoured inactive and well-camouflaged individuals. Notably, camouflage dampened selection on activity rate, likely by reducing attack rates when Epitheca encountered a predator. Correlational selection is therefore conferred by the ecological interaction of traits, rather than by opposing selection acting on linked traits. I suggest that antipredator traits with different adaptive functions can jointly structure patterns of consumption and selection. © 2018 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2018 European Society For Evolutionary Biology.

  11. [Functional characteristics of flexible supporting structures for heart valve bioprosthesis].

    Science.gov (United States)

    Dobrova, N B; Agafonov, A V; Barbarash, L S; Zavalishin, N N; Neniukov, A K

    1984-01-01

    Hydraulic characteristics of heart valve bioprostheses mounted on supporting structures of various rigidity have been studied under physiologic conditions. An actual mobility of the supporting structures made of different polymers is determined. Static and dynamic components of the support displacements have been shown to develop as the bioprosthesis is under the load, the dynamic component being strongly dependent upon the rigidity of fastening the bioprosthesis on the axis. It is noted that considerable improvements in hydraulic characteristics of bioprostheses are achieved through the use of flexible supporting structures.

  12. Metallic and Non-Metallic Materials for the Primary Support Structure

    International Nuclear Information System (INIS)

    RA Wolf; RP Corson

    2006-01-01

    The primary support structure (PSS) is required for mechanical support of reactor module (RM) components and mounting of the RM to the spacecraft. The PSS would provide support and accept all loads associated with dynamic (e. g., launch and maneuvering) or thermally induced loading. Prior to termination of NRPCT involvement in Project Prometheus, the NRPCT Mechanical Systems team developed preliminary finite element models to gain a basic understanding of the behavior of the structure, but optimization of the models, specification of the final design, and materials selection were not completed. The Space Plant Materials team had evaluated several materials for potential use in the primary support structure, namely titanium alloys, beryllium, aluminum alloys and carbon-carbon composites. The feasibility of application of each material system was compared based on mass, stiffness, thermal expansion, and ease of fabrication. Due to insufficient data on environmental factors, such as temperatures and radiation, and limited modeling support, a final materials selection was not made

  13. Towards a Tool for Computer Supported Structuring of Products

    DEFF Research Database (Denmark)

    Hansen, Claus Thorp

    1997-01-01

    . However, a product possesses not only a component structure but also various organ structures which are superimposed on the component structure. The organ structures carry behaviour and make the product suited for its life phases.Our long-term research goal is to develop a computer-based system...... that is capable of supporting synthesis activities in engineering design, and thereby also support handling of various organ structures. Such a system must contain a product model, in which it is possible to describe and manipulate both various organ structures and the component structure.In this paper we focus...... on the relationships between organ structures and the component structure. By an analysis of an existing product it is shown that a component may contribute to more than one organ. A set of organ structures is identified and their influence on the component strucute is illustrated....

  14. Child Support Payment: A Structural Model of Predictive Variables.

    Science.gov (United States)

    Wright, David W.; Price, Sharon J.

    A major area of concern in divorced families is compliance with child support payments. Aspects of the former spouse relationship that are predictive of compliance with court-ordered payment of child support were investigated in a sample of 58 divorced persons all of whom either paid or received child support. Structured interviews and…

  15. Selection of powered roof support for weak coal roof

    Energy Technology Data Exchange (ETDEWEB)

    Ramayya, M.S.V.; Sudhakar, L. [Singareni Collieries Co. Ltd., Kothagudem (India)

    2002-04-01

    Singareni Collieries Company Ltd (SCCL) introduced mechanised longwall mining in 1983. The first few faces were worked with conventional and immediate forward supports (IFS), with capacities in the range of 360 to 450 t. These under capacity supports increased from abutment loads and there was breakage of roof in front of the supports which resulted in closure of powered roof supports, followed by face cavities. The cavities were more frequent and were difficult to negotiate especially in case of IFS supports. Subsequently, support capacity was increased at Padmavati Khani (PVK) mine and at GDK.10a and GKD.9LFP Inclines where the roof is composed of weak, coal, shale and clay. Problems related to failure of hydraulics/legs etc., which are repairable have occurred; though the problems are not totally eliminated, there was definite improvement in strata control with these higher capacity supports. Monitoring of supports was conducted all through the working of longwall panels. The data generated while working these longwall faces were analysed to study the suitability of other types of powered roof supports, namely 2 legged shield supports/4 legged supports for improved strata control. The analysis and practical experiences suggest that in weak, coaly, shale and clay roofs 2 legged shield supports offer better roof control. 4 refs., 4 figs.

  16. Model structure selection in convolutive mixtures

    DEFF Research Database (Denmark)

    Dyrholm, Mads; Makeig, S.; Hansen, Lars Kai

    2006-01-01

    The CICAAR algorithm (convolutive independent component analysis with an auto-regressive inverse model) allows separation of white (i.i.d) source signals from convolutive mixtures. We introduce a source color model as a simple extension to the CICAAR which allows for a more parsimonious represent......The CICAAR algorithm (convolutive independent component analysis with an auto-regressive inverse model) allows separation of white (i.i.d) source signals from convolutive mixtures. We introduce a source color model as a simple extension to the CICAAR which allows for a more parsimonious...... representation in many practical mixtures. The new filter-CICAAR allows Bayesian model selection and can help answer questions like: ’Are we actually dealing with a convolutive mixture?’. We try to answer this question for EEG data....

  17. Examining the Support Peer Supporters Provide Using Structural Equation Modeling: Nondirective and Directive Support in Diabetes Management.

    Science.gov (United States)

    Kowitt, Sarah D; Ayala, Guadalupe X; Cherrington, Andrea L; Horton, Lucy A; Safford, Monika M; Soto, Sandra; Tang, Tricia S; Fisher, Edwin B

    2017-12-01

    Little research has examined the characteristics of peer support. Pertinent to such examination may be characteristics such as the distinction between nondirective support (accepting recipients' feelings and cooperative with their plans) and directive (prescribing "correct" choices and feelings). In a peer support program for individuals with diabetes, this study examined (a) whether the distinction between nondirective and directive support was reflected in participants' ratings of support provided by peer supporters and (b) how nondirective and directive support were related to depressive symptoms, diabetes distress, and Hemoglobin A1c (HbA1c). Three hundred fourteen participants with type 2 diabetes provided data on depressive symptoms, diabetes distress, and HbA1c before and after a diabetes management intervention delivered by peer supporters. At post-intervention, participants reported how the support provided by peer supporters was nondirective or directive. Confirmatory factor analysis (CFA), correlation analyses, and structural equation modeling examined the relationships among reports of nondirective and directive support, depressive symptoms, diabetes distress, and measured HbA1c. CFA confirmed the factor structure distinguishing between nondirective and directive support in participants' reports of support delivered by peer supporters. Controlling for demographic factors, baseline clinical values, and site, structural equation models indicated that at post-intervention, participants' reports of nondirective support were significantly associated with lower, while reports of directive support were significantly associated with greater depressive symptoms, altogether (with control variables) accounting for 51% of the variance in depressive symptoms. Peer supporters' nondirective support was associated with lower, but directive support was associated with greater depressive symptoms.

  18. Spectrally-Selective Photonic Structures for PV Applications

    Directory of Open Access Journals (Sweden)

    Benedikt Bläsi

    2010-01-01

    Full Text Available We review several examples of how spectrally-selective photonic structures may be used to improve solar cell systems. Firstly, we introduce different spectrally-selective structures that are based on interference effects. Examples shown include Rugate filter, edge filter and 3D photonic crystals such as artificial opals. In the second part, we discuss several examples of photovoltaic (PV concepts that utilize spectral selectivity such as fluorescence collectors, upconversion systems, spectrum splitting concepts and the intermediate reflector concept. The potential of spectrally selective filters in the context of solar cells is discussed.

  19. APT/LEDA RFQ and support frame structural analysis

    International Nuclear Information System (INIS)

    Ellis, S.

    1997-01-01

    This report documents structural analysis of the Accelerator Production of Tritium Low Energy Demonstration Accelerator (APT/LEDA) Radio Frequency Quadrupole (RFQ) accelerator structure and its associated support frame. This work was conducted for the Department of Energy in support of the APT/LEDA. Structural analysis of the RFQ was performed to quantify stress levels and deflections due to both vacuum loading and gravity loading. This analysis also verified the proposed support scheme geometry and quantified interface loads. This analysis also determined the necessary stiffness and strength requirements of the RFQ support frame verifying the conceptual design geometry and allowing specification of individual frame elements. Complete structural analysis of the frame was completed subsequently. This report details structural analysis of the RFQ assembly with regard to gravity and vacuum loads only. Thermally induced stresses from the Radio Frequency (RF) surface resistance heating were not considered

  20. Nuclear fuel assembly incorporating primary and secondary structural support members

    International Nuclear Information System (INIS)

    Carlson, W.R.; Gjertsen, R.K.; Miller, J.V.

    1987-01-01

    A nuclear fuel assembly, comprising: (a) an upper end structure; (b) a lower end structure; (c) elongated primary structural members extending longitudinally between and rigidly interconnecting the upper and lower end structures, the upper and lower end structures and primary structural members together forming a rigid structural skeleton of the fuel assembly; (d) transverse grids supported on the primary structural members at axially spaced locations therealong between the upper and lower end structures; (e) fuel rods extending through and supported by the grids between the upper and lower end structures so as to extend in generally side-by-side spaced relation to one another and to the primary structural members; and (f) elongated secondary structural members extending longitudinally between but unconnected with the upper and lower end structures, the secondary structural members extending through and rigidly interconnected with the grids to extend in generally side-by-side spaced relation to one another, to the fuel rods and to the primary structural members so as to bolster the stiffness of the structural skeleton of the fuel assembly

  1. A novel selection method of seismic attributes based on gray relational degree and support vector machine.

    Directory of Open Access Journals (Sweden)

    Yaping Huang

    Full Text Available The selection of seismic attributes is a key process in reservoir prediction because the prediction accuracy relies on the reliability and credibility of the seismic attributes. However, effective selection method for useful seismic attributes is still a challenge. This paper presents a novel selection method of seismic attributes for reservoir prediction based on the gray relational degree (GRD and support vector machine (SVM. The proposed method has a two-hierarchical structure. In the first hierarchy, the primary selection of seismic attributes is achieved by calculating the GRD between seismic attributes and reservoir parameters, and the GRD between the seismic attributes. The principle of the primary selection is that these seismic attributes with higher GRD to the reservoir parameters will have smaller GRD between themselves as compared to those with lower GRD to the reservoir parameters. Then the SVM is employed in the second hierarchy to perform an interactive error verification using training samples for the purpose of determining the final seismic attributes. A real-world case study was conducted to evaluate the proposed GRD-SVM method. Reliable seismic attributes were selected to predict the coalbed methane (CBM content in southern Qinshui basin, China. In the analysis, the instantaneous amplitude, instantaneous bandwidth, instantaneous frequency, and minimum negative curvature were selected, and the predicted CBM content was fundamentally consistent with the measured CBM content. This real-world case study demonstrates that the proposed method is able to effectively select seismic attributes, and improve the prediction accuracy. Thus, the proposed GRD-SVM method can be used for the selection of seismic attributes in practice.

  2. Manufacture and installation of JET MKII divertor support structure

    International Nuclear Information System (INIS)

    Celentano, G.; Altmann, H.; Macklin, B.; Miele, P.; Pick, M.A.; Tait, J.; Moletta, L.; Romagnolo, A.; Shaw, R.

    1995-01-01

    The water cooled support structure, comprising twenty-four modules is the main component of the JET MKII divertor system. It is to be installed in the vacuum vessel with high accuracy with respect to the magnetic center and the other in-vessel components. The paper describes the design and manufacturing cycle including the required tolerances, the assembly and installation method and the material production process required to ensure the accuracy and reliability of the MKII support structure system. The water cooling holes, machined into the support structure require the procurement of special material to prevent risks of leaks inside the vacuum vessel

  3. System for Selection of Relevant Information for Decision Support

    Czech Academy of Sciences Publication Activity Database

    Kalina, Jan; Seidl, L.; Zvára, K.; Grünfeldová, H.; Slovák, Dalibor; Zvárová, Jana

    2013-01-01

    Roč. 1, č. 1 (2013), s. 46-46 ISSN 1805-8698. [EFMI 2013 Special Topic Conference. 17.04.2013-19.04.2013, Prague] Institutional support: RVO:67985807 Keywords : decision support system * web-service * information extraction * high-dimension * gene expressions Subject RIV: IN - Informatics, Computer Science

  4. The development of design method of nuclear piping system supported by elasto-plastic support structures (part 2)

    International Nuclear Information System (INIS)

    Endo, R.; Murota, M.; Kawabata, J-I.; Hirose, J.; Nekomoto, Y.; Takayama, Y.; Kobayashi, H.

    1995-01-01

    The conventional seismic design method of nuclear piping system is very conservative because of the accumulation of various safety factors in the design process, and nuclear piping systems are thought to have a large safety margin. Considering this situations, research program was promoted to furthermore rationalize nuclear power plants by reducing the amount of support structures and reducing the piping's seismic response through vibration energy absorption resulting from the elasto-plastic behavior of piping support structures. The research had the following three stages. In the first stage, we selected conventional piping support structures in light-water reactors that exhibited elasto-plastic behavior, and studied the effect of displacement and the vibration frequency on the stiffness and on the energy absorption by testing these models. In the second stage, vibration tests were performed using piping models with support structures on shaking tables. The piping vibration characteristics were clarified by sinusoidal sweep tests and the piping response characteristics by seismic wave vibration tests when the support structures were in an elasto-plastic condition. In the third stage, a general method was developed to evaluate the characteristics of a variety of support structures in the tests. A simplified analysis method was also developed to evaluate the piping seismic response using the piping model test result. To expand the results mentioned above, we also established a new seismic design method of piping systems that allowed support structures to have elasto-plastic behavior. This paper reports the newly developed seismic design method based on the results of experiments conducted under the joint research program of Japanese electric power companies (The Japan Atomic Power Co., Hokkaido EPC, Tohoku EPC, Tokyo EPC, Chubu EPC, Hokuriku EPC, Kansai EPC, Chugoku EPC, Shikoku EPC, Kyushu EPC) and nuclear plant makers (Hitachi Ltd., Toshiba Co., MHI Ltd., HEC Ltd

  5. Supporting domain experts to select and configure precise compliance rules

    NARCIS (Netherlands)

    Ramezani, E.; Fahland, D.; Aalst, van der W.M.P.; Lohmann, N.; Song, M.; Wohed, P.

    2014-01-01

    Compliance specifications concisely describe selected aspects of what a business operation should adhere to. To enable automated techniques for compliance checking, it is important that these requirements are specified correctly and precisely, describing exactly the behavior intended. Although there

  6. Risk and uncertainty in the structure of management decision support

    International Nuclear Information System (INIS)

    Valeca, Serban Constantin

    2002-01-01

    The monograph is structured into five chapters addressing the following subject matters: 1 - The risk descriptor implied by the power systems with nuclear injection; 1.1 - Concepts and operators for describing the nuclear power risk; 1.2 - Risk approach in a holistic conception; 2 - Modelling the risk in the frame of re-engineering concept; 2.1 - Defining and interpreting the power re-engineering; 2.2 - Managerial re-engineering of power production systems; 3 - Informatics system of managing the power objectives with nuclear injection; 3.1 - Informatics systems for risk at the level of CANDU - 600 nuclear plant; 3.2. - Expert function structure applicable to the management of power objectives with nuclear injection; 4 - Assisting support in the operation of nuclear facilities; 4.1 - Assisting support system for nuclear plant operation; 4.2 - Program products for dedicated drivers; 5 - The management decision activities at the level of power systems with nuclear injection; 5.1 - Preliminaries in making power decision; 5.2 - Applications of decision models of sustainable power systems with nuclear injection; 5.3 - Re-engineering of power decision in the frame of maximal utility theory. The successful application of re-engineering concept is based on knowledge and managing capacity of design leadership and its ability of dealing the error generating sources. The main stages of implementing successfully the re-engineering are: - Replacing the pollution processes instead of adjusting measures; - Raising the designer responsibility by radical innovation of processes' architecture; - Re-designing the processes by basic changes at the level of the management functions and structures; - Raising the personnel professionalism by motivation as optimal way of improving the workers mentalities; - Accurate definition of objectives in the frame of re-engineering program; - Application of re-engineering in industrial units starting from the management level; - Selecting as general

  7. Enhanced Activity and Selectivity of Carbon Nanofiber Supported Pd Catalysts for Nitrite Reduction

    KAUST Repository

    Shuai, Danmeng; Choe, Jong Kwon; Shapley, John R.; Werth, Charles J.

    2012-01-01

    Pd-based catalyst treatment represents an emerging technology that shows promise to remove nitrate and nitrite from drinking water. In this work we use vapor-grown carbon nanofiber (CNF) supports in order to explore the effects of Pd nanoparticle size and interior versus exterior loading on nitrite reduction activity and selectivity (i.e., dinitrogen over ammonia production). Results show that nitrite reduction activity increases by 3.1-fold and selectivity decreases by 8.0-fold, with decreasing Pd nanoparticle size from 1.4 to 9.6 nm. Both activity and selectivity are not significantly influenced by Pd interior versus exterior CNF loading. Consequently, turnover frequencies (TOFs) among all CNF catalysts are similar, suggesting nitrite reduction is not sensitive to Pd location on CNFs nor Pd structure. CNF-based catalysts compare favorably to conventional Pd catalysts (i.e., Pd on activated carbon or alumina) with respect to nitrite reduction activity and selectivity, and they maintain activity over multiple reduction cycles. Hence, our results suggest new insights that an optimum Pd nanoparticle size on CNFs balances faster kinetics with lower ammonia production, that catalysts can be tailored at the nanoscale to improve catalytic performance for nitrite, and that CNFs hold promise as highly effective catalyst supports in drinking water treatment. © 2012 American Chemical Society.

  8. Enhanced Activity and Selectivity of Carbon Nanofiber Supported Pd Catalysts for Nitrite Reduction

    KAUST Repository

    Shuai, Danmeng

    2012-03-06

    Pd-based catalyst treatment represents an emerging technology that shows promise to remove nitrate and nitrite from drinking water. In this work we use vapor-grown carbon nanofiber (CNF) supports in order to explore the effects of Pd nanoparticle size and interior versus exterior loading on nitrite reduction activity and selectivity (i.e., dinitrogen over ammonia production). Results show that nitrite reduction activity increases by 3.1-fold and selectivity decreases by 8.0-fold, with decreasing Pd nanoparticle size from 1.4 to 9.6 nm. Both activity and selectivity are not significantly influenced by Pd interior versus exterior CNF loading. Consequently, turnover frequencies (TOFs) among all CNF catalysts are similar, suggesting nitrite reduction is not sensitive to Pd location on CNFs nor Pd structure. CNF-based catalysts compare favorably to conventional Pd catalysts (i.e., Pd on activated carbon or alumina) with respect to nitrite reduction activity and selectivity, and they maintain activity over multiple reduction cycles. Hence, our results suggest new insights that an optimum Pd nanoparticle size on CNFs balances faster kinetics with lower ammonia production, that catalysts can be tailored at the nanoscale to improve catalytic performance for nitrite, and that CNFs hold promise as highly effective catalyst supports in drinking water treatment. © 2012 American Chemical Society.

  9. Selective control of attention supports the positivity effect in aging.

    Directory of Open Access Journals (Sweden)

    Laura K Sasse

    Full Text Available There is emerging evidence for a positivity effect in healthy aging, which describes an age-specific increased focus on positive compared to negative information. Life-span researchers have attributed this effect to the selective allocation of cognitive resources in the service of prioritized emotional goals. We explored the basic principles of this assumption by assessing selective attention and memory for visual stimuli, differing in emotional content and self-relevance, in young and old participants. To specifically address the impact of cognitive control, voluntary attentional selection during the presentation of multiple-item displays was analyzed and linked to participants' general ability of cognitive control. Results revealed a positivity effect in older adults' selective attention and memory, which was particularly pronounced for self-relevant stimuli. Focusing on positive and ignoring negative information was most evident in older participants with a generally higher ability to exert top-down control during visual search. Our findings highlight the role of controlled selectivity in the occurrence of a positivity effect in aging. Since the effect has been related to well-being in later life, we suggest that the ability to selectively allocate top-down control might represent a resilience factor for emotional health in aging.

  10. Selective control of attention supports the positivity effect in aging.

    Science.gov (United States)

    Sasse, Laura K; Gamer, Matthias; Büchel, Christian; Brassen, Stefanie

    2014-01-01

    There is emerging evidence for a positivity effect in healthy aging, which describes an age-specific increased focus on positive compared to negative information. Life-span researchers have attributed this effect to the selective allocation of cognitive resources in the service of prioritized emotional goals. We explored the basic principles of this assumption by assessing selective attention and memory for visual stimuli, differing in emotional content and self-relevance, in young and old participants. To specifically address the impact of cognitive control, voluntary attentional selection during the presentation of multiple-item displays was analyzed and linked to participants' general ability of cognitive control. Results revealed a positivity effect in older adults' selective attention and memory, which was particularly pronounced for self-relevant stimuli. Focusing on positive and ignoring negative information was most evident in older participants with a generally higher ability to exert top-down control during visual search. Our findings highlight the role of controlled selectivity in the occurrence of a positivity effect in aging. Since the effect has been related to well-being in later life, we suggest that the ability to selectively allocate top-down control might represent a resilience factor for emotional health in aging.

  11. Seismic structural response analysis for multiple support excitation

    International Nuclear Information System (INIS)

    Shaw, D.E.

    1975-01-01

    In the seismic analysis of nuclear power plant equipment such as piping systems situations often arise in which piping systems span between adjacent structures or between different elevations in the same structure. Owing to the differences in the seismic time history response of different structures or different elevations of the same structure, the input support motion will differ for different supports. The concept of a frequency dependent participation factor and rotational response spectra accounting for phase differences between support excitations is developed by using classical equations of motion to formulate the seismic response of a structure subjected to multiple support excitation. The essence of the method lies in describing the seismic excitation of a multiply excited structure in terms of translational and rotational spectra used at every support and a frequency dependent spatial distribution function derived from the phase relationships of the different support time histories. In this manner it is shown that frequency dependent participation factors can be derived from the frequency dependent distribution functions. Examples are shown and discussed relative to closed form solutions and the state-of-the-art techniques presently being used for the solution of problems of multiply excited structures

  12. Learners' experiences of learning support in selected Western Cape schools

    Directory of Open Access Journals (Sweden)

    Olaniyi Bojuwoye

    2014-01-01

    Full Text Available The study explored Western Cape primary and secondary school learners' experiences regarding the provision and utilization of support services for improving learning. A qualitative interpretive approach was adopted and data gathered through focus group interviews involving 90 learners. Results revealed that learners received and utilized various forms of learning support from their schools, teachers, and peers. The learning support assisted in meeting learners' academic, social and emotional needs by addressing barriers to learning, creating conducive learning environments, enhancing learners' self-esteem and improving learners' academic performance.

  13. Fatigue risks in the connections of sign support structures.

    Science.gov (United States)

    2013-05-01

    This research effort develops a reliability-based approach for prescribing inspection intervals for mast-arm sign support : structures corresponding to user-specified levels of fatigue-induced fracture risk. The resulting level of risk for a : partic...

  14. Hybrid feature selection for supporting lightweight intrusion detection systems

    Science.gov (United States)

    Song, Jianglong; Zhao, Wentao; Liu, Qiang; Wang, Xin

    2017-08-01

    Redundant and irrelevant features not only cause high resource consumption but also degrade the performance of Intrusion Detection Systems (IDS), especially when coping with big data. These features slow down the process of training and testing in network traffic classification. Therefore, a hybrid feature selection approach in combination with wrapper and filter selection is designed in this paper to build a lightweight intrusion detection system. Two main phases are involved in this method. The first phase conducts a preliminary search for an optimal subset of features, in which the chi-square feature selection is utilized. The selected set of features from the previous phase is further refined in the second phase in a wrapper manner, in which the Random Forest(RF) is used to guide the selection process and retain an optimized set of features. After that, we build an RF-based detection model and make a fair comparison with other approaches. The experimental results on NSL-KDD datasets show that our approach results are in higher detection accuracy as well as faster training and testing processes.

  15. Indicial response test for the support post structure of VHTR

    International Nuclear Information System (INIS)

    Futakawa, Masatoshi; Kikuchi, Kenji; Tachibana, Katsumi; Muto, Yasushi

    1985-11-01

    Fuel blocks and removable reflector blocks, which constitute a core of VHTR, are supported by support posts. Each support post is in contact with a hot plenum block at the top end and with a lower plenum block at the bottom end through hemispherical seats to absorb a relative displacement generated by the lateral movement of both blocks by means of small inclination or rotation of support posts. Indicial response tests have been carried out by using a specified one-dimensional vibration model in order to estimate the effects of the support post length, the mass of hot plenum block and the hemispherical radii of both support and post seat on the vibrational characteristics in the support post structure. Futhermore the experimental results have been compared with the analytical ones obtained from the Lagrange's equation. The following are the conclusions derived. (1) The hemispherical radii of support post and post seat have a large effect on the frequency of vibration in the support post structure. (2) The frequency of vibration in the support post structure is predictable using the Lagrange's equation. (author)

  16. Development of piping support structure design software based on PDMS

    International Nuclear Information System (INIS)

    Tang Yongtao; Guan Hui; Su Rongfu; Huang Wei; Mao Huihui

    2014-01-01

    In order to enhance the efficiency of nuclear power process system piping support design, the veracity of interface with support, piping and anchor, and decrease the clash between supports and other disciplines, developed piping support structure design software NPHS based on PDMS independently. That achieved the seamless integration of PDMS and NPHS by method of embedded development, reduce the size of program code, improve the running efficiency; That predigested the 3D modeling and information storage for support parts, that increased the support database opening and maintenance using the special mechanism and configuration of database. The support modeling efficiency due to setting of the connection key point of support parts is improved. Practices in several real nuclear power projects proved that NPHS software is provided with such outstanding performances: quick running, strong stability, accurate data, easy to operate and maintain, and output results satisfied the engineering requirements. (authors)

  17. Creating a Structured Support System for Postsecondary Success

    Science.gov (United States)

    White, Carol Cutler

    2018-01-01

    For numerous reasons, it can be difficult for foster youth to succeed in postsecondary education. This chapter offers insight into state-level policies and programs, community college programs dedicating to supporting foster youth, and a framework for creating a structured support system to increase student success.

  18. Selective Ring Opening of 1-Methylnaphthalene Over NiW-Supported Catalyst Using Dealuminated Beta Zeolite.

    Science.gov (United States)

    Kim, Eun-Sang; Lee, You-Jin; Kim, Jeong-Rang; Kim, Joo-Wan; Kim, Tae-Wan; Chae, Ho-Jeong; Kim, Chul-Ung; Lee, Chang-Ha; Jeong, Soon-Yong

    2016-02-01

    Nanoporous Beta zeolite was dealuminated by weak acid treatment for reducing the acidity. Bi-functional catalysts were prepared using commercial Beta zeolites and the dealuminated zeolites for acidic function, NiW for metallic function. 1-Methylnaphthalene was selected as a model compound for multi-ring aromatics in heavy oil, and its selective ring opening reaction has been investigated using the prepared bi-functional catalysts with different acidity in fixed bed reaction system. The dealuminated Beta zeolites, which crystal structure and nanoporosity were maintained, showed the higher SiO2/Al2O3 ratio and smaller acidity than their original zeolite. NiW-supported catalyst using the dealuminated Beta zeolite with SiO2/Al203 mole ratio of 55 showed the highest performance for the selective ring opening. The acidity of catalyst seemed to play an important role as active sites for the selective ring opening of 1-methylnaphthalene but there should be some optimum catalyst acidity for the reaction. The acidity of Beta zeolite could be controlled by the acid treatment and the catalyst with the optimum acidity for the selective ring opening could be prepared.

  19. Integrated Multidisciplinary Constrained Optimization of Offshore Support Structures

    International Nuclear Information System (INIS)

    Haghi, Rad; Molenaar, David P; Ashuri, Turaj; Van der Valk, Paul L C

    2014-01-01

    In the current offshore wind turbine support structure design method, the tower and foundation, which form the support structure are designed separately by the turbine and foundation designer. This method yields a suboptimal design and it results in a heavy, overdesigned and expensive support structure. This paper presents an integrated multidisciplinary approach to design the tower and foundation simultaneously. Aerodynamics, hydrodynamics, structure and soil mechanics are the modeled disciplines to capture the full dynamic behavior of the foundation and tower under different environmental conditions. The objective function to be minimized is the mass of the support structure. The model includes various design constraints: local and global buckling, modal frequencies, and fatigue damage along different stations of the structure. To show the usefulness of the method, an existing SWT-3.6-107 offshore wind turbine where its tower and foundation are designed separately is used as a case study. The result of the integrated multidisciplinary design optimization shows 12.1% reduction in the mass of the support structure, while satisfying all the design constraints

  20. Design and Analysis of Muon Beam Stop Support Structures

    Energy Technology Data Exchange (ETDEWEB)

    Okafor, Udenna [Northern Illinois Univ., DeKalb, IL (United States)

    2015-01-01

    The primary objective of this thesis is to design and analyze support structures to be used in the installation, test and final positioning of the MBS throughout the life of the Mu2e experiment. There several requirements for the MBS imposed by both the scope of the experiment and, other components within the DS bore. The functions of the MBS are: 1. To limit the induced rates in the Tracker, the Calorimeter and the Cosmic Ray Veto due to backsplash-and-secondary interactions, and 2. To reduce radiation levels external to the Detector solenoid. The structures used in supporting the MBS will also adhere to requirements imposed by its functions. These requirements are critical to the support structures and affect design decisions. Other requirements critical to the design are imposed by the weight, positional tolerance and assembly procedure of the MBS, and also, the magnetic field and vacuum dose rate of the DS bore. A detailed breakdown of how each requirement affects the structural design can be found in chapter 2. Chapter 3 describes the design of each support structure and its attachment to the MBS while chapter 4 describes the results from structural analysis of the support structures. Chapter 5 describes evaluation for the design through testing and calculations while the conclusion in chapter 6 reports the current status at the time of this thesis submission with a plan for future work to be completed until final design and installation.

  1. Single-Atom Catalyst of Platinum Supported on Titanium Nitride for Selective Electrochemical Reactions.

    Science.gov (United States)

    Yang, Sungeun; Kim, Jiwhan; Tak, Young Joo; Soon, Aloysius; Lee, Hyunjoo

    2016-02-05

    As a catalyst, single-atom platinum may provide an ideal structure for platinum minimization. Herein, a single-atom catalyst of platinum supported on titanium nitride nanoparticles were successfully prepared with the aid of chlorine ligands. Unlike platinum nanoparticles, the single-atom active sites predominantly produced hydrogen peroxide in the electrochemical oxygen reduction with the highest mass activity reported so far. The electrocatalytic oxidation of small organic molecules, such as formic acid and methanol, also exhibited unique selectivity on the single-atom platinum catalyst. A lack of platinum ensemble sites changed the reaction pathway for the oxygen-reduction reaction toward a two-electron pathway and formic acid oxidation toward direct dehydrogenation, and also induced no activity for the methanol oxidation. This work demonstrates that single-atom platinum can be an efficient electrocatalyst with high mass activity and unique selectivity. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Criteria for the selection of PEC primary circuit structural material

    International Nuclear Information System (INIS)

    Antoni, R.; Brunori, G.; Maesa, S.; Scibona, G.; Tomassetti, G.

    1977-01-01

    The choice of the structural materials is generally a compromise between the project requirements, the characteristics (mechanical and environmental) of the materials and the available technology to construct the various parts of the components. The criteria of selection of structural materials for the primary circuit of fast reactor are reported. The criteria concern both general and utilization aspects

  3. TFTR Inner Support Structure final assembly and installation

    International Nuclear Information System (INIS)

    Rocco, R.E.; Brown, G.; Carglia, G.; Heitzenroeder, P.; Koenig, F.; Mookerjee, S.; Raugh, J.

    1983-01-01

    The Inner Support Structure (ISS) of the TFTR provides a specific level of restraint to the net centering force and overturning moment produced by the Toroidal Field (TF) coils and to the vertical forces produced by the Inner Poloidal Field (PF) coils. This is accomplished consistent with the need for four radial dielectric breaks running the entire length of the ISS to prevent eddy current loops. A brief description of the major components, method of manufacture and material selection of the ISS and PF coils is presented. Particular attention is given to the integration of the PF coils and the ISS components into the total assembly and the installation of strain gauges and crack monitors on the ISS. The requirements of no gaps at the interfaces of the ISS teeth at all three horizontal planes is discussed. The problem encountered with achieving the no gap requirement and the successful resolution of this problem, including its impact on installation of the ISS, is also discussed. The installation of the ISS, including setting in position, preloading with TF coil clips, and final tensioning of the tension bars is discussed. A brief description of the lower and upper lead stem splicing operation is presented. Subsequent to the final assembly, electrical tests were performed prior to and after installation on the TFTR machine. An overview of the tests and their results is presented

  4. Structure for common access and support of fuel cell stacks

    Science.gov (United States)

    Walsh, Michael M.

    2000-01-01

    A structure provides common support and access to multiple fuel cells externally mounted thereto. The structure has openings leading to passages defined therein for providing the access. Various other fuel cell power system components are connected at the openings, such as reactant and coolant sources.

  5. Rules for selection of computer system to support customer relationships management

    Directory of Open Access Journals (Sweden)

    Dorota Buchnowska

    2012-12-01

    Full Text Available The number of support systems for business management on the Polish market is increasing. Because of that, enterprises are facing a more and more difficult dilemma: which solution to choose? This paper will present stages of the selection process of applications for customer relationships management support, discuss selection criteria and present a decision making tool for the selection of management support system, allowing for multi-faceted and impartial comparison of business applications.

  6. Supporting farmers in maintaining and selecting seeds of local varieties

    NARCIS (Netherlands)

    Almekinders, C.J.M.; Louwaars, N.P.

    2009-01-01

    This book addresses strategies and approaches through which professionals can support informal seed supply, and link these with the conservation and use of the huge genetic resource base of crops and local varieties. The aim of all the strategies, case studies and reflections on experiences

  7. Learners' experiences of learning support in selected Western Cape ...

    African Journals Online (AJOL)

    The learning support assisted in meeting learners' academic, social and emotional needs by addressing barriers to learning, creating conducive learning environments, enhancing learners' self-esteem and improving learners' academic performance. Keywords: academic needs; academic performance; barriers to learning; ...

  8. Schwann Cell Glycogen Selectively Supports Myelinated Axon Function

    Science.gov (United States)

    Brown, Angus M; Evans, Richard D; Black, Joel; Ransom, Bruce R

    2012-01-01

    Objectives Interruption of energy supply to peripheral axons is a cause of axon loss. We determined if glycogen was present in mammalian peripheral nerve, and if it supported axon conduction during aglycemia. Methods We used biochemical assay and electron microscopy to determine the presence of glycogen, and electrophysiology to monitor axon function. Results Glycogen was present in sciatic nerve, its concentration varying directly with ambient [glucose]. Electron microscopy detected glycogen granules primarily in myelinating Schwann cell cytoplasm and these diminished after exposure to aglycemia. During aglycemia, conduction failure in large myelinated axons (A fibers) mirrored the time-course of glycogen loss. Latency to CAP failure was directly related to nerve glycogen content at aglycemia onset. Glycogen did not benefit the function of slow-conducting, small diameter unmyelinated axons (C fibers) during aglycemia. Blocking glycogen breakdown pharmacologically accelerated CAP failure during aglycemia in A fibers, but not in C fibers. Lactate was as effective as glucose in supporting sciatic nerve function, and was continuously released into the extracellular space in the presence of glucose and fell rapidly during aglycemia. Interpretation Our findings indicated that glycogen is present in peripheral nerve, primarily in myelinating Schwann cells, and exclusively supports large diameter, myelinated axon conduction during aglycemia. Available evidence suggests that peripheral nerve glycogen breaks down during aglycemia and is passed, probably as lactate, to myelinated axons to support function. Unmyelinated axons are not protected by glycogen and are more vulnerable to dysfunction during periods of hypoglycemia. PMID:23034913

  9. Five Novel Selection Policies for N2R Network Structures

    DEFF Research Database (Denmark)

    Pedersen, Jens Myrup; Riaz, Muhammad Tahir; Madsen, Ole Brun

    2006-01-01

    This paper shows how 5 new selection policies can be applied to N2R structures. For each number of nodes, a selection policy determines which topology is chosen. Compared to approaches taken previously, the policies proposed in this paper allow us to choose structures which are significantly easi...... to implement, while having only slightly longer distances. The 5 policies reflect different trade-offs between distances and ease of implementation, and two of them explore the potentials of using N2R(p; q; r) instead of N2R(p; q) structures....

  10. STRUCTURE RATIONALIZATION OF TANK CARS SUPPORT DEVICES FOR FLUIDS

    Directory of Open Access Journals (Sweden)

    M. V. Pavliuchenkov

    2014-01-01

    Full Text Available Purpose. Improvement of fluid tank cars structure due to development of new tank bracket support structures and their materials consumption decrease. Methodology. The investigations to search the optimal design of the support structure were conducted in order to solve such problem. At the first stage patent and bibliographic analysis of technical solutions was done, the advantages and disadvantages were revealed and new design options were proposed, the most efficient design was determined. The next step is objective function making for determining its optimal parameters, imposition of restrictions, acquisition of objective function approximation and restrictions in the form of polynomials. At the third stage numerical implementation of function optimization was proposed, optimal design parameters were determined with graphical method. Results methods have coincided. Findings. The most efficient design of support structure was determined; its optimum geometrical dimensions were described. Originality. The author provides the mathematical formulation of optimal design of tank car supports using the minimum materials consumption criteria. The graphic and numerical methods were used during the investigations. Practical value. The author proposed the finite-element models of tank car with different design execution of bracket support structures, which allow estimating the VAT of structure.

  11. Selection and Participation in Higher Education: University Selection in Support of Student Success and Diversity of Participation

    Science.gov (United States)

    Palmer, Nigel; Bexley, Emmaline; James, Richard

    2011-01-01

    A range of imperatives underpin university selection practices. These include demonstrating merit based on prior academic achievement and supporting successful graduate outcomes in the professions and in broader fields of endeavour. They also include improving diversity of participation and equality of educational opportunity. Selection for…

  12. Selecting effective persuasive strategies in behavior change support systems: Third International Workshop on Behavior Change Support Systems (BCSS 2015)

    NARCIS (Netherlands)

    Kelders, Saskia Marion; Kulyk, Olga Anatoliyivna; van Gemert-Pijnen, Julia E.W.C.; Oinas-Kukkonen, Harri; Kelders, Saskia; Kulyk, Olga; van Gemert-Pijnen, Lisette; Oinas-Kukkonen, Harri

    2015-01-01

    The Third International Workshop on Behavior Change Support Systems provides a place to discuss recent advances in BCSS research. The selected papers show that research into behavior change support systems is expanding: not only by trying to reach more and other people, but also by expanding the

  13. Database system selection for marketing strategies support in information systems

    Directory of Open Access Journals (Sweden)

    František Dařena

    2007-01-01

    Full Text Available In today’s dynamically changing environment marketing has a significant role. Creating successful marketing strategies requires large amount of high quality information of various kinds and data types. A powerful database management system is a necessary condition for marketing strategies creation support. The paper briefly describes the field of marketing strategies and specifies the features that should be provided by database systems in connection with these strategies support. Major commercial (Oracle, DB2, MS SQL, Sybase and open-source (PostgreSQL, MySQL, Firebird databases are than examined from the point of view of accordance with these characteristics and their comparison in made. The results are useful for making the decision before acquisition of a database system during information system’s hardware architecture specification.

  14. Atomic structure of graphene supported heterogeneous model catalysts

    International Nuclear Information System (INIS)

    Franz, Dirk

    2017-04-01

    Graphene on Ir(111) forms a moire structure with well defined nucleation centres. Therefore it can be utilized to create hexagonal metal cluster lattices with outstanding structural quality. At diffraction experiments these 2D surface lattices cause a coherent superposition of the moire cell structure factor, so that the measured signal intensity scales with the square of coherently scattering unit cells. This artificial signal enhancement enables the opportunity for X-ray diffraction to determine the atomic structure of small nano-objects, which are hardly accessible with any experimental technique. The uniform environment of every metal cluster makes the described metal cluster lattices on graphene/Ir(111) an attractive model system for the investigation of catalytic, magnetic and quantum size properties of ultra-small nano-objects. In this context the use of x-rays provides a maximum of flexibility concerning the possible sample environments (vacuum, selected gases, liquids, sample temperature) and allows in-situ/operando measurements. In the framework of the present thesis the structure of different metal clusters grown by physical vapor deposition in an UHV environment and after gas exposure have been investigated. On the one hand the obtained results will explore many aspects of the atomic structure of these small metal clusters and on the other hand the presented results will proof the capabilities of the described technique (SXRD on cluster lattices). For iridium, platinum, iridium/palladium and platinum/rhodium the growth on graphene/Ir(111) of epitaxial, crystalline clusters with an ordered hexagonal lattice arrangement has been confirmed using SXRD. The clusters nucleate at the hcp sites of the moire cell and bind via rehybridization of the carbon atoms (sp"2 → sp"3) to the Ir(111) substrate. This causes small displacements of the substrate atoms, which is revealed by the diffraction experiments. All metal clusters exhibit a fcc structure, whereupon

  15. Ceramic-supported thin PVA pervaporation membranes combining high flux and high selectivity : contradicting the flux-selectivity paradigm

    NARCIS (Netherlands)

    Peters, T.A.; Poeth, C.H.S.; Benes, N.E.; Buijs, H.C.W.M.; Vercauteren, F.F.; Keurentjes, J.T.F.

    2006-01-01

    Thin, high-flux and highly selective cross-linked poly(vinyl)alcohol waterselective layers have been prepared on top of hollow fibre ceramic supports. The supports consist of an alpha-Al2O3 hollow fibre substrate and an intermediate gamma-Al2O3 layer, which provides a sufficiently smooth surface for

  16. Evaluating Restorative Justice Circles of Support and Accountability: Can Social Support Overcome Structural Barriers?

    Science.gov (United States)

    Bohmert, Miriam Northcutt; Duwe, Grant; Hipple, Natalie Kroovand

    2018-02-01

    In a climate in which stigmatic shaming is increasing for sex offenders as they leave prison, restorative justice practices have emerged as a promising approach to sex offender reentry success and have been shown to reduce recidivism. Criminologists and restorative justice advocates believe that providing ex-offenders with social support that they may not otherwise have is crucial to reducing recidivism. This case study describes the expressive and instrumental social support required and received, and its relationship to key outcomes, by sex offenders who participated in Circles of Support and Accountability (COSAs), a restorative justice, reentry program in Minnesota. In-depth interviews with re-entering sex offenders and program volunteers revealed that 75% of offenders reported weak to moderate levels of social support leaving prison, 70% reported receiving instrumental support in COSAs, and 100% reported receiving expressive support. Findings inform work on social support, structural barriers, and restorative justice programming during sex offender reentry.

  17. Selective maintenance of multi-state systems with structural dependence

    International Nuclear Information System (INIS)

    Dao, Cuong D.; Zuo, Ming J.

    2017-01-01

    This paper studies the selective maintenance problem for multi-state systems with structural dependence. Each component can be in one of multiple working levels and several maintenance actions are possible to a component in a maintenance break. The components structurally form multiple hierarchical levels and dependence groups. A directed graph is used to represent the precedence relations of components in the system. A selective maintenance optimization model is developed to maximize the system reliability in the next mission under time and cost constraints. A backward search algorithm is used to determine the assembly sequence for a selective maintenance scenario. The maintenance model helps maintenance managers in determining the best combination of maintenance activities to maximize the probability of successfully completing the next mission. Examples showing the use of the proposed method are presented. - Highlights: • A selective maintenance model for multi-state systems is proposed considering both economic and structural dependence. • Structural dependence is modeled as precedence relationship when disassembling components for maintenance. • Resources for disassembly and maintenance are evaluated using a backward search algorithm. • Maintenance strategies with and without structural dependence are analyzed. • Ignoring structural dependence may lead to over-estimation of system reliability.

  18. The optimum support design selection by using AHP method for the main haulage road in WLC Tuncbilek colliery

    Energy Technology Data Exchange (ETDEWEB)

    Yavuz, M.; Iphar, M.; Once, G.

    2008-03-15

    The engineers can frequently encounter with the situation to select the optimum option among the alternatives related with mining operations. The optimum choice can be selected by the experienced engineers taking into consideration their judgement and intuition. However, decision-making methods can offer to the engineers to support their optimum selection for a particular application in the scientific way. The Analytical Hierarchy Process (AHP) is one of the multi attribute decision-making (MADM) methods utilizing structured pair-wise comparisons. This paper presents an application of the AHP method to the selection of the optimum support design for the main transport road, which has been planned for deep coal seam panels of Western Lignite Corporation (WLC) Tuncbilek in Turkeiy. The methodology considers eight main objectives, namely: four different displacement values for determined history locations, factor of safety (FOS), cost, labour and applicability factor for the selection of support design. The displacements and stress values were obtained by using the finite difference program FLAC(3D) as the numerical studies have been widely used by the engineers examining the response of any opening in underground, in advance. After carrying out several numerical models for different support design, the AHP method was incorporated to evaluate these support designs according to the pre-determined criteria. The result of this study shows that such AHP application can assist the engineers to effectively evaluate the support system alternatives for an underground mine.

  19. Vertical load analysis of cylindrical ACS support structures

    International Nuclear Information System (INIS)

    Kennedy, J.M.; Belytschko, T.B.

    1984-01-01

    A new concept in LMFBR design ACS (above-core structures) supports which has generated some interest is to use a single large radius cylinder. The advantages of a single cylinder are reduced cost of fabrication, increased lateral stiffness, which enhances seismic resistance, and easier access to the fuel. However, the performance of these support structures when submitted to vertical loads from the core area may be substantially different, for the buckling and postbuckling behavior of a cylinder differs substantially from that of cylindrical beams. In this paper, a comparative analysis of an old prototypical support by 4 columns is compared with a cylindrical support. It is assumed that the single cylinder replaces the 4 columns in the original design. The dimensions of the two designs are compared

  20. Stress analysis on a PWR pressure vessel support structure

    International Nuclear Information System (INIS)

    Cruz, J.R.B.; Mattar Neto, M.; Jesus Miranda, C.A. de.

    1992-01-01

    The paper presents the stress analysis of a research PWR vessel support structure. Different geometries and thermal boundary conditions are evaluated. The finite element analysis is performed using ANSYS program. The ASME Section III criteria are applied for the stress verification and the following points are discussed: stress classification and linearization; jurisdictional boundary between ASME Subsection NB (Class 1 Components) and Subsection NF (Component Supports). (author)

  1. New Insight into Carbon Nanotube Electronic Structure Selectivity

    Energy Technology Data Exchange (ETDEWEB)

    Sumpter, Bobby G [ORNL; Meunier, Vincent [ORNL; Jiang, Deen [ORNL

    2009-01-01

    The fundamental role of aryl diazonium salts for post synthesis selectivity of carbon nanotubes is investigated using extensive electronic structure calculations. The resulting understanding for diazonium salt based selective separation of conducting and semiconducting carbon nanotubes shows how the primary contributions come from the interplay between the intrinsic electronic structure of the carbon nanotubes and that of the anion of the salt. We demonstrate how the electronic transport properties change upon the formation of charge transfer complexes and upon their conversion into covalently attached functional groups. Our results are found to correlate well with experiments and provide for the first time an atomistic description for diazonium salt based chemical separation of carbon nanotubes

  2. Self-supporting rhombic infill structures for additive manufacturing

    DEFF Research Database (Denmark)

    Wu, Jun; Wang, Charlie C.L.; Zhang, Xiaoting

    2016-01-01

    Recent work has demonstrated that the interior material layout of a 3D model can be designed to make a fabricated replica satisfy application-specific demands on its physical properties, such as resistance to external loads. A widely used practice to fabricate such models is by layer-based additive...... manufacturing (AM), which however suffers from the problem of adding and removing interior supporting structures. In this paper, we present a novel method for generating application-specific infill structures on rhombic cells so that the resultant structures can automatically satisfy manufacturing requirements...... on overhang-angle and wall-thickness. Additional supporting structures can be avoided entirely in our framework. To achieve this, we introduce the usage of an adaptive rhombic grid, which is built from an input surface model. Starting from the initial sparse set of rhombic cells, via numerical optimization...

  3. Superconducting magnetic energy storage apparatus structural support system

    Science.gov (United States)

    Withers, Gregory J.; Meier, Stephen W.; Walter, Robert J.; Child, Michael D.; DeGraaf, Douglas W.

    1992-01-01

    A superconducting magnetic energy storage apparatus comprising a cylindrical superconducting coil; a cylindrical coil containment vessel enclosing the coil and adapted to hold a liquid, such as liquefied helium; and a cylindrical vacuum vessel enclosing the coil containment vessel and located in a restraining structure having inner and outer circumferential walls and a floor; the apparatus being provided with horizontal compression members between (1) the coil and the coil containment vessel and (2) between the coil containment vessel and the vacuum vessel, compression bearing members between the vacuum vessel and the restraining structure inner and outer walls, vertical support members (1) between the coil bottom and the coil containment vessel bottom and (2) between the coil containment vessel bottom and the vacuum vessel bottom, and external supports between the vacuum vessel bottom and the restraining structure floor, whereby the loads developed by thermal and magnetic energy changes in the apparatus can be accommodated and the structural integrity of the apparatus be maintained.

  4. A model selection support system for numerical simulations of nuclear thermal-hydraulics

    International Nuclear Information System (INIS)

    Gofuku, Akio; Shimizu, Kenji; Sugano, Keiji; Yoshikawa, Hidekazu; Wakabayashi, Jiro

    1990-01-01

    In order to execute efficiently a dynamic simulation of a large-scaled engineering system such as a nuclear power plant, it is necessary to develop intelligent simulation support system for all phases of the simulation. This study is concerned with the intelligent support for the program development phase and is engaged in the adequate model selection support method by applying AI (Artificial Intelligence) techniques to execute a simulation consistent with its purpose and conditions. A proto-type expert system to support the model selection for numerical simulations of nuclear thermal-hydraulics in the case of cold leg small break loss-of-coolant accident of PWR plant is now under development on a personal computer. The steps to support the selection of both fluid model and constitutive equations for the drift flux model have been developed. Several cases of model selection were carried out and reasonable model selection results were obtained. (author)

  5. Selective small-molecule inhibition of an RNA structural element

    Energy Technology Data Exchange (ETDEWEB)

    Howe, John A.; Wang, Hao; Fischmann, Thierry O.; Balibar, Carl J.; Xiao, Li; Galgoci, Andrew M.; Malinverni, Juliana C.; Mayhood, Todd; Villafania, Artjohn; Nahvi, Ali; Murgolo, Nicholas; Barbieri, Christopher M.; Mann, Paul A.; Carr, Donna; Xia, Ellen; Zuck, Paul; Riley, Dan; Painter, Ronald E.; Walker, Scott S.; Sherborne, Brad; de Jesus, Reynalda; Pan, Weidong; Plotkin, Michael A.; Wu, Jin; Rindgen, Diane; Cummings, John; Garlisi, Charles G.; Zhang, Rumin; Sheth, Payal R.; Gill, Charles J.; Tang, Haifeng; Roemer , Terry (Merck)

    2015-09-30

    Riboswitches are non-coding RNA structures located in messenger RNAs that bind endogenous ligands, such as a specific metabolite or ion, to regulate gene expression. As such, riboswitches serve as a novel, yet largely unexploited, class of emerging drug targets. Demonstrating this potential, however, has proven difficult and is restricted to structurally similar antimetabolites and semi-synthetic analogues of their cognate ligand, thus greatly restricting the chemical space and selectivity sought for such inhibitors. Here we report the discovery and characterization of ribocil, a highly selective chemical modulator of bacterial riboflavin riboswitches, which was identified in a phenotypic screen and acts as a structurally distinct synthetic mimic of the natural ligand, flavin mononucleotide, to repress riboswitch-mediated ribB gene expression and inhibit bacterial cell growth. Our findings indicate that non-coding RNA structural elements may be more broadly targeted by synthetic small molecules than previously expected.

  6. Nonlinear structural damage detection using support vector machines

    Science.gov (United States)

    Xiao, Li; Qu, Wenzhong

    2012-04-01

    An actual structure including connections and interfaces may exist nonlinear. Because of many complicated problems about nonlinear structural health monitoring (SHM), relatively little progress have been made in this aspect. Statistical pattern recognition techniques have been demonstrated to be competitive with other methods when applied to real engineering datasets. When a structure existing 'breathing' cracks that open and close under operational loading may cause a linear structural system to respond to its operational and environmental loads in a nonlinear manner nonlinear. In this paper, a vibration-based structural health monitoring when the structure exists cracks is investigated with autoregressive support vector machine (AR-SVM). Vibration experiments are carried out with a model frame. Time-series data in different cases such as: initial linear structure; linear structure with mass changed; nonlinear structure; nonlinear structure with mass changed are acquired.AR model of acceleration time-series is established, and different kernel function types and corresponding parameters are chosen and compared, which can more accurate, more effectively locate the damage. Different cases damaged states and different damage positions have been recognized successfully. AR-SVM method for the insufficient training samples is proved to be practical and efficient on structure nonlinear damage detection.

  7. Seismic Dynamic Damage Characteristics of Vertical and Batter Pile-supported Wharf Structure Systems

    Directory of Open Access Journals (Sweden)

    Li Jiren

    2015-10-01

    Full Text Available Considering a typical steel pipe pile-supported wharf as the research object, finite element analytical models of batter and vertical pile structures were established under the same construction site, service, and geological conditions to investigate the seismic dynamic damage characteristics of vertical and batter pile-supported wharf structures. By the numerical simulation and the nonlinear time history response analysis of structure system and the moment–axial force relation curve, we analyzed the dynamic damage characteristics of the two different structures of batter and vertical piles under different seismic ground motions to provide reasonable basis and reference for designing and selecting a pile-supported wharf structure. Results showed that the axial force of batter piles was dominant in the batter pile structure and that batter piles could effectively bear and share seismic load. Under the seismic ground motion with peak ground acceleration (PGA of 350 Gal and in consideration of the factors of the design requirement of horizontal displacement, the seismic performance of the batter pile structure was better than that of the vertical pile structure. Under the seismic ground motion with a PGA of 1000 Gal, plastic failure occurred in two different structures. The contrastive analysis of the development of plastic damage and the absorption and dissipation for seismic energy indicated that the seismic performance of the vertical pile structure was better than that of the batter pile structure.

  8. Training set optimization under population structure in genomic selection.

    Science.gov (United States)

    Isidro, Julio; Jannink, Jean-Luc; Akdemir, Deniz; Poland, Jesse; Heslot, Nicolas; Sorrells, Mark E

    2015-01-01

    Population structure must be evaluated before optimization of the training set population. Maximizing the phenotypic variance captured by the training set is important for optimal performance. The optimization of the training set (TRS) in genomic selection has received much interest in both animal and plant breeding, because it is critical to the accuracy of the prediction models. In this study, five different TRS sampling algorithms, stratified sampling, mean of the coefficient of determination (CDmean), mean of predictor error variance (PEVmean), stratified CDmean (StratCDmean) and random sampling, were evaluated for prediction accuracy in the presence of different levels of population structure. In the presence of population structure, the most phenotypic variation captured by a sampling method in the TRS is desirable. The wheat dataset showed mild population structure, and CDmean and stratified CDmean methods showed the highest accuracies for all the traits except for test weight and heading date. The rice dataset had strong population structure and the approach based on stratified sampling showed the highest accuracies for all traits. In general, CDmean minimized the relationship between genotypes in the TRS, maximizing the relationship between TRS and the test set. This makes it suitable as an optimization criterion for long-term selection. Our results indicated that the best selection criterion used to optimize the TRS seems to depend on the interaction of trait architecture and population structure.

  9. Relating performance of thin-film composite forward osmosis membranes to support layer formation and structure

    KAUST Repository

    Tiraferri, Alberto

    2011-02-01

    Osmotically driven membrane processes have the potential to treat impaired water sources, desalinate sea/brackish waters, and sustainably produce energy. The development of a membrane tailored for these processes is essential to advance the technology to the point that it is commercially viable. Here, a systematic investigation of the influence of thin-film composite membrane support layer structure on forward osmosis performance is conducted. The membranes consist of a selective polyamide active layer formed by interfacial polymerization on top of a polysulfone support layer fabricated by phase separation. By systematically varying the conditions used during the casting of the polysulfone layer, an array of support layers with differing structures was produced. The role that solvent quality, dope polymer concentration, fabric layer wetting, and casting blade gate height play in the support layer structure formation was investigated. Using a 1M NaCl draw solution and a deionized water feed, water fluxes ranging from 4 to 25Lm-2h-1 with consistently high salt rejection (>95.5%) were produced. The relationship between membrane structure and performance was analyzed. This study confirms the hypothesis that the optimal forward osmosis membrane consists of a mixed-structure support layer, where a thin sponge-like layer sits on top of highly porous macrovoids. Both the active layer transport properties and the support layer structural characteristics need to be optimized in order to fabricate a high performance forward osmosis membrane. © 2010 Elsevier B.V.

  10. Research success and structured support: Developing early career ...

    African Journals Online (AJOL)

    This article discusses the programme structure, participants' evaluation of the year-long intervention and longitudinal data from a follow-up study conducted in 2008. It is evident in studies conducted in South Africa (Geber 2006) and elsewhere (Sorcinelli 2000) that support including mentoring and coaching is necessary for ...

  11. Structural damage in masonry : Developing diagnostic decision support

    NARCIS (Netherlands)

    De Vent, I.A.E.

    2011-01-01

    This thesis deals with the diagnosis of structural damage in traditional masonry: cracks, deformations and tilts. Establishing the cause of this type of damage can be difficult. This research project has aimed to improve and facilitate the diagnostic process by offering support in the initial phase

  12. Effect of chemically reduced palladium supported catalyst on sunflower oil hydrogenation conversion and selectivity

    Directory of Open Access Journals (Sweden)

    Abdulmajid Alshaibani

    2017-02-01

    Full Text Available Catalytic hydrogenation of sunflower oil was studied in order to improve the conversion and to reduce the trans-isomerization selectivity. The hydrogenation was performed using Pd–B/γ-Al2O3 prepared catalyst and Pd/Al2O3 commercial catalyst under similar conditions. The Pd–B/γ-Al2O3 catalyst was prepared by wet impregnation and chemical reduction processes. It was characterized by Brunauer–Emmett–Teller surface area analysis (BET, X-ray powder diffraction (XRD, scanning electron microscopy (SEM, and transmission electron microscopy (TEM. The result of sunflower oil hydrogenation on Pd–B/γ-Al2O3 catalyst showed a 17% higher conversion and a 23% lower trans-isomerization selectivity compared to the commercial Pd/Al2O3 catalyst. The chemical reduction of palladium supported catalyst using potassium borohydride (KBH4 has affected the Pd–B/γ-Al2O3 catalyst’s structure and particle size. These most likely influenced its catalytic performance toward higher conversion and lower trans-isomerization selectivity.

  13. Discourse, Paragraph, and Sentence Structure in Selected Philippine Languages. Final Report. Volume II, Sentence Structure.

    Science.gov (United States)

    Longacre, Robert E.

    Volume II of "Discourse, Paragraph, and Sentence Structure in Selected Philippine Languages" begins with an explanation of certain assumptions and postulates regarding sentence structure. A detailed treatment of systems of sentence structure and the parameters of such systems follows. Data in the various indigenous languages are…

  14. Structural Characteristics of Bimetallic Catalysts Supported on Nano-Ceria

    Directory of Open Access Journals (Sweden)

    J. F. Bozeman

    2011-01-01

    Full Text Available Cu-Pt bimetal catalysts supported on nanocrystalline CeO2 (nano-ceria are synthesized via the low-cost sol-gel approach followed by impregnation processing. The average particle size of the catalytic composites is 63 nm. Ceria nanopowders sequentially impregnated in copper solution and then in Pt solution transformed into Pt-skin-structured Cu-Pt/ceria nanocomposite, based on the surface elemental and bulk compositional analyses. The ceria supporter has a fluorite structure, but the structure of Cu and Pt catalytic contents, not detected by X-ray diffraction spectroscopy due to the low loading level, is yet conclusive. The bimetallic catalytic nanocomposites may potentially serve as sulfur-tolerant anode in solid oxide fuel cells.

  15. Argumentative SOX Compliant and Quality Decision Support Intelligent Expert System over the Suppliers Selection Process

    Directory of Open Access Journals (Sweden)

    Jesus Angel Fernandez Canelas

    2013-01-01

    Full Text Available The objective of this paper is to define a decision support system over SOX (Sarbanes-Oxley Act compatibility and quality of the Suppliers Selection Process based on Artificial Intelligence and Argumentation Theory knowledge and techniques. The present SOX Law, in effect nowadays, was created to improve financial government control over US companies. This law is a factor standard out United States due to several factors like present globalization, expansion of US companies, or key influence of US stock exchange markets worldwide. This paper constitutes a novel approach to this kind of problems due to following elements: (1 it has an optimized structure to look for the solution, (2 it has a dynamic learning method to handle court and control gonvernment bodies decisions, (3 it uses fuzzy knowledge to improve its performance, and (4 it uses its past accumulated experience to let the system evolve far beyond its initial state.

  16. Decision support for selecting exportable nuclear technology using the analytic hierarchy process: A Korean case

    International Nuclear Information System (INIS)

    Lee, Deok Joo; Hwang, Jooho

    2010-01-01

    The Korean government plans to increase strategically focused R and D investment in some promising nuclear technology areas to create export opportunities of technology in a global nuclear market. The purpose of this paper is to present a decision support process for selecting promising nuclear technology with the perspective of exportability by using the AHP based on extensive data gathered from nuclear experts in Korea. In this study, the decision criteria for evaluating the export competitiveness of nuclear technologies were determined, and a hierarchical structure for the decision-making process was systematically developed. Subsequently relative weights of decision criteria were derived using AHP methodology and the export competitiveness of nuclear technology alternatives was quantified to prioritize them. We discuss the implications of our results with a viewpoint toward national nuclear technology policy.

  17. Catalyst support structure, catalyst including the structure, reactor including a catalyst, and methods of forming same

    Science.gov (United States)

    Van Norman, Staci A.; Aston, Victoria J.; Weimer, Alan W.

    2017-05-09

    Structures, catalysts, and reactors suitable for use for a variety of applications, including gas-to-liquid and coal-to-liquid processes and methods of forming the structures, catalysts, and reactors are disclosed. The catalyst material can be deposited onto an inner wall of a microtubular reactor and/or onto porous tungsten support structures using atomic layer deposition techniques.

  18. Structural Support of High-Performance Athletes' Education: Supporting Dual Careers in Greece

    Science.gov (United States)

    Pavlidis, George; Gargalianos, Dimitris

    2014-01-01

    This article describes how the current Greek sport-education context seems to offer relatively poor dual-career support in comparison to other available structures in the world. This results in additional obstacles for Greek athletes who wish to educate themselves and an ambiguous prospect for their future. Consequently, the Greek…

  19. Scope and selection of structures subject to aging management review

    International Nuclear Information System (INIS)

    Mendoza, G.; Diaz, A.; Viais, J.; Carmona, M.; Santander, L.

    2014-10-01

    The purpose of this work is to determine the structures included within the scope of license renewal based on the performance of the functions and select those intended for aging management review; one purpose is to show the methodology used to establish the structure and structural components that are subject to a review of aging management, within the framework of license renewal rule. This is through the application of different types of structures and structural components related and unrelated to safety located in the rooms of the reactor building where there are components of the reactor core isolation cooling system (Rcic), these structures are poured concrete, concrete block, structural steel, shielding walls, attached metal, pile foundations, etc.; other non- security related , such as: 1) inherent characteristics not related to security that protect the equipment related to the safety of the missiles, that is, walls, low walls, dikes, doors, etc., which also provide flood barriers to structures, systems and components related to safety, 2 ) whipping restrictions on non- security, shields mitigation jet, vent panels , etc. that are designed and installed to protect equipment related with the safety of the effects of a broken line of high energy. Only rooms where there are components of the Rcic 68 structures within the scope were identified. (Author)

  20. Atomic structure of graphene supported heterogeneous model catalysts

    Energy Technology Data Exchange (ETDEWEB)

    Franz, Dirk

    2017-04-15

    Graphene on Ir(111) forms a moire structure with well defined nucleation centres. Therefore it can be utilized to create hexagonal metal cluster lattices with outstanding structural quality. At diffraction experiments these 2D surface lattices cause a coherent superposition of the moire cell structure factor, so that the measured signal intensity scales with the square of coherently scattering unit cells. This artificial signal enhancement enables the opportunity for X-ray diffraction to determine the atomic structure of small nano-objects, which are hardly accessible with any experimental technique. The uniform environment of every metal cluster makes the described metal cluster lattices on graphene/Ir(111) an attractive model system for the investigation of catalytic, magnetic and quantum size properties of ultra-small nano-objects. In this context the use of x-rays provides a maximum of flexibility concerning the possible sample environments (vacuum, selected gases, liquids, sample temperature) and allows in-situ/operando measurements. In the framework of the present thesis the structure of different metal clusters grown by physical vapor deposition in an UHV environment and after gas exposure have been investigated. On the one hand the obtained results will explore many aspects of the atomic structure of these small metal clusters and on the other hand the presented results will proof the capabilities of the described technique (SXRD on cluster lattices). For iridium, platinum, iridium/palladium and platinum/rhodium the growth on graphene/Ir(111) of epitaxial, crystalline clusters with an ordered hexagonal lattice arrangement has been confirmed using SXRD. The clusters nucleate at the hcp sites of the moire cell and bind via rehybridization of the carbon atoms (sp{sup 2} → sp{sup 3}) to the Ir(111) substrate. This causes small displacements of the substrate atoms, which is revealed by the diffraction experiments. All metal clusters exhibit a fcc structure

  1. Support System Model for Value based Group Decision on Roof System Selection

    Directory of Open Access Journals (Sweden)

    Christiono Utomo

    2011-02-01

    Full Text Available A group decision support system is required on a value-based decision because there are different concern caused by differing preferences, experiences, and background. It is to enable each decision-maker to evaluate and rank the solution alternatives before engaging into negotiation with other decision-makers. Stakeholder of multi-criteria decision making problems usually evaluates the alternative solution from different perspective, making it possible to have a dominant solution among the alternatives. Each stakeholder needs to identify the goals that can be optimized and those that can be compromised in order to reach an agreement with other stakeholders. This paper presents group decision model involving three decision-makers on the selection of suitable system for a building’s roof. The objective of the research is to find an agreement options model and coalition algorithms for multi person decision with two main preferences of value which are function and cost. The methodology combines value analysis method using Function Analysis System Technique (FAST; Life Cycle Cost analysis, group decision analysis method based on Analytical Hierarchy Process (AHP in a satisfying options, and Game theory-based agent system to develop agreement option and coalition formation for the support system. The support system bridges theoretical gap between automated design in construction domain and automated negotiation in information technology domain by providing a structured methodology which can lead to systematic support system and automated negotiation. It will contribute to value management body of knowledge as an advanced method for creativity and analysis phase, since the practice of this knowledge is teamwork based. In the case of roof system selection, it reveals the start of the first negotiation round. Some of the solutions are not an option because no individual stakeholder or coalition of stakeholders desires to select it. The result indicates

  2. Performance of structured lipids incorporating selected phenolic and ascorbic acids.

    Science.gov (United States)

    Gruczynska, Eliza; Przybylski, Roman; Aladedunye, Felix

    2015-04-15

    Conditions applied during frying require antioxidant which is stable at these conditions and provides protection for frying oil and fried food. Novel structured lipids containing nutraceuticals and antioxidants were formed by enzymatic transesterification, exploring canola oil and naturally occurring antioxidants such as ascorbic and selected phenolic acids as substrates. Lipozyme RM IM lipase from Rhizomucor miehei was used as biocatalyst. Frying performance and oxidative stability of the final transesterification products were evaluated. The novel lipids showed significantly improved frying performance compared to canola oil. Oxidative stability assessment of the structured lipids showed significant improvement in resistance to oxidative deterioration compared to original canola oil. Interestingly, the presence of ascorbic acid in an acylglycerol structure protected α-tocopherol against thermal degradation, which was not observed for the phenolic acids. Developed structured lipids containing nutraceuticals and antioxidants may directly affect nutritional properties of lipids also offering nutraceutical ingredients for food formulation. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Shape-Selection of Thermodynamically Stabilized Colloidal Pd and Pt Nanoparticles Controlled via Support Effects

    DEFF Research Database (Denmark)

    Ahmadi, M.; Behafarid, F.; Holse, Christian

    2015-01-01

    Colloidal chemistry, in combination with nanoparticle (NP)/support epitaxial interactions is used here to synthesize shape-selected and thermodynamically stable metallic NPs over a broad range of NP sizes. The morphology of three-dimensional palladium and platinum NPs supported on TiO2(110) was i......Colloidal chemistry, in combination with nanoparticle (NP)/support epitaxial interactions is used here to synthesize shape-selected and thermodynamically stable metallic NPs over a broad range of NP sizes. The morphology of three-dimensional palladium and platinum NPs supported on TiO2...... rows and was found to be responsible for the shape control. The ability of synthesizing thermally stable shape-selected metal NPs demonstrated here is expected to be of relevance for applications in the field of catalysis, since the activity and selectivity of NP catalysts has been shown to strongly...

  4. Control structure selection for energy integrated distillation column

    DEFF Research Database (Denmark)

    Hansen, J.E.; Jørgensen, Sten Bay

    1998-01-01

    This paper treats a case study on control structure selection for an almost binary distillation column. The column is energy integrated with a heat pump in order to transfer heat from the condenser to the reboiler. This integrated plant configuration renders the possible control structures somewhat...... different from what is usual for binary distillation columns. Further the heat pump enables disturbances to propagate faster through the system. The plant has six possible actuators of which three must be used to stabilize the system. Hereby three actuators are left for product purity control. An MILP...

  5. Supporting undergraduate nursing students through structured personal tutoring: Some reflections.

    Science.gov (United States)

    Watts, Tessa E

    2011-02-01

    Support is imperative for nursing students worldwide as they face the many challenges associated with learning and working. Moreover enhancing student retention is an increasing concern for institutions across the globe. The personal tutor is a frequently hidden yet potentially significant figure in many students' experience of higher education. This paper offers some critical reflections on a structured approach to personal tutoring within an undergraduate nursing programme in a research focused Welsh university. Structured personal tutoring can provide an organised, coherent and proactive support system throughout students' educational programmes. However the approach changes the shape of personal tutoring and has the potential to increase academics' workloads and with it costs. Copyright © 2010 Elsevier Ltd. All rights reserved.

  6. Structural features of subtype-selective EP receptor modulators.

    Science.gov (United States)

    Markovič, Tijana; Jakopin, Žiga; Dolenc, Marija Sollner; Mlinarič-Raščan, Irena

    2017-01-01

    Prostaglandin E2 is a potent endogenous molecule that binds to four different G-protein-coupled receptors: EP1-4. Each of these receptors is a valuable drug target, with distinct tissue localisation and signalling pathways. We review the structural features of EP modulators required for subtype-selective activity, as well as the structural requirements for improved pharmacokinetic parameters. Novel EP receptor subtype selective agonists and antagonists appear to be valuable drug candidates in the therapy of many pathophysiological states, including ulcerative colitis, glaucoma, bone healing, B cell lymphoma, neurological diseases, among others, which have been studied in vitro, in vivo and in early phase clinical trials. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  7. Seismic Base Isolators For A Silo Supporting Structure

    Directory of Open Access Journals (Sweden)

    Bîtcă Daniel

    2015-05-01

    Full Text Available A 3000 tones capacity silo, located in a seismic area with ground acceleration ag = 0,20g and TC =1,0s, was designed in a classical solution The supporting structure has an octagonal shape in planview, and columns with “Maltese cross sections”. The main lateral resisting system is made up of centric bracings with cross-section class I.

  8. Design integration of favorable geometry, structural support and containment

    International Nuclear Information System (INIS)

    Purcell, J.A.; McGehee, G.A.

    1991-07-01

    In designs for fissile processes at Savannah River site, different approaches have been used to provide engineered margins of safety for criticality with containment and seismic resistance as additional requirements. These requirements are frequently at odds in engineered systems. This paper proposes a plan to take advantage of vessels with favorable geometry to provide seismic resistance and to support a glovebox for containment. Thin slab tanks, small diameter pencil tanks, annular tanks, and other novel designs have been used for criticality safety. The requirement for DBE seismic resistance and rigid control of dimensions leads the designer to consider annular tanks for meeting these requirements. The high strength of annular tanks may logically be used to support secondary containment. Hands-on access to all instruments, piping etc. within containment can be provided through gloveports, thus a specialized glovebox. This paper examines the advantages of using an annular tank design to provide favorable geometry, structural support and containment

  9. Tethered and Polymer Supported Bilayer Lipid Membranes: Structure and Function

    Directory of Open Access Journals (Sweden)

    Jakob Andersson

    2016-05-01

    Full Text Available Solid supported bilayer lipid membranes are model systems to mimic natural cell membranes in order to understand structural and functional properties of such systems. The use of a model system allows for the use of a wide variety of analytical tools including atomic force microscopy, impedance spectroscopy, neutron reflectometry, and surface plasmon resonance spectroscopy. Among the large number of different types of model membranes polymer-supported and tethered lipid bilayers have been shown to be versatile and useful systems. Both systems consist of a lipid bilayer, which is de-coupled from an underlying support by a spacer cushion. Both systems will be reviewed, with an emphasis on the effect that the spacer moiety has on the bilayer properties.

  10. Decision support systems in water and wastewater treatment process selection and design: a review.

    Science.gov (United States)

    Hamouda, M A; Anderson, W B; Huck, P M

    2009-01-01

    The continuously changing drivers of the water treatment industry, embodied by rigorous environmental and health regulations and the challenge of emerging contaminants, necessitates the development of decision support systems for the selection of appropriate treatment trains. This paper explores a systematic approach to developing decision support systems, which includes the analysis of the treatment problem(s), knowledge acquisition and representation, and the identification and evaluation of criteria controlling the selection of optimal treatment systems. The objective of this article is to review approaches and methods used in decision support systems developed to aid in the selection, sequencing of unit processes and design of drinking water, domestic wastewater, and industrial wastewater treatment systems. Not surprisingly, technical considerations were found to dominate the logic of the developed systems. Most of the existing decision-support tools employ heuristic knowledge. It has been determined that there is a need to develop integrated decision support systems that are generic, usable and consider a system analysis approach.

  11. Selective Hydrogenation of Biomass-derived Furfural over Supported Ni3Sn2 Alloy: Role of Supports

    Directory of Open Access Journals (Sweden)

    Rodiansono Rodiansono

    2016-03-01

    Full Text Available A highly active and selective hydrogenation of biomass-derived furfural into furfuryl alcohol was achieved using supported single phase Ni3Sn2 alloy catalysts. Various supports such as active carbon (AC, g-Al2O3, Al(OH3, ZnO, TiO2, ZrO2, MgO, Li-TN, and SiO2 have been employed in order to understand the role of the support on the formation of Ni3Sn2 alloy phase and its catalytic performance. Supported Ni3Sn2 alloy catalysts were synthesised via a simple hydrothermal treatment of the mixture of aqueous solution of nickel chloride hexahydrate and ethanol solution of tin(II chloride dihydrate in presence of ethylene glycol at 423 K for 24 h followed by H2 treatment at 673 K for 1.5 h, then characterised by using ICP-AES, XRD, H2- and N2-adsorption. XRD profiles of samples showed that the Ni3Sn2 alloy phases are readily formed during hydrothermal processes and become clearly observed at 2θ = 43-44o after H2 treatment. The presence of Ni3Sn2 alloy species that dispersed on the supports is believed to play a key role in highly active and selective hydrogenation of biomass-derived furfural towards furfuryl alcohol. Ni3Sn2 on TiO2 and ZnO supports exhibited much lower reaction temperature to achieved >99% yield of furfuryl alcohol product compared with other supports. The effects of loading amount of Ni-Sn, reaction conditions (temperature and time profile on the activity and selectivity towards the desired product are systematically discussed. Copyright © 2016 BCREC GROUP. All rights reserved Received: 10th November 2015; Revised: 31st December 2015; Accepted: 5th January 2016 How to Cite: Rodiansono, R., Astuti, M.D., Khairi, S., Shimazu, S. (2016. Selective Hydrogenation of Biomass-derived Furfural over Supported Ni3Sn2 Alloy: Role of Supports. Bulletin of Chemical Reaction Engineering & Catalysis, 11 (1: 1-9. (doi:10.9767/bcrec.11.1.393.1-9 Permalink/DOI: http://dx.doi.org/10.9767/bcrec.11.1.393.1-9

  12. Quantification of Structural Isomers via Mode-Selective Irmpd

    Science.gov (United States)

    Polfer, Nicolas C.

    2016-06-01

    Mixtures of structural isomers can pose a challenge for vibrational ion spectroscopy. In cases where particular structures display diagnostic vibrations, these structures can be selectively "burned away". In ion traps, the ion population can be subjected to multiple laser shots, in order to fully deplete a particular structure, in effect allowing a quantification of this structure. Protonated para-amino benzoic acid (PABA) serves as an illustrative example. PABA is known to preferentially exist in the N-protonated (N-prot) form in solution, but in the gas phase it is energetically favorable in the O-protonated (O-prot) form. As shown in Figure 1, the N-prot structure can be kinetically trapped in the gas phase when sprayed from non-protic solvent, whereas the O-prot structure is obtained when sprayed from protic solvents, analogous to results by others [1,2]. y parking the light source on the diagnostic 3440 wn mode, the percentage of the O-prot structure can be determined, and by default the remainder is assumed to adopt the N-prot structure. It will be shown that the relative percentages of O-prot vs N-prot are highly dependent on the solvent mixture, going from close to 0% O-prot in non-protic solvents, to 99% in protic solvents. Surprisingly, water behaves much more like a non-protic solvent than methanol. It is observed that the capillary temperature, which aids droplet desolvation by black-body radiation in the ESI source, is critical to promote the appearance of O-prot structures. These results are consistent with the picture that a protic bridge mechanism is at play to facilitate proton transfer, and thus allow conversion from N-prot to O-prot, but that this mechanism is subject to appreciable kinetic barriers on the timescale of solvent evaporation. 1. J. Phys. Chem. A 2011, 115, 7625. 2. Anal. Chem. 2012, 84, 7857.

  13. Making Plant-Support Structures From Waste Plant Fiber

    Science.gov (United States)

    Morrow, Robert C.; < oscjmocl. < attjew K/; {ertzbprm. A,amda; Ej (e. Cjad); Hunt, John

    2006-01-01

    Environmentally benign, biodegradable structures for supporting growing plants can be made in a process based on recycling of such waste plant fiber materials as wheat straw or of such derivative materials as paper and cardboard. Examples of structures that can be made in this way include plant plugs, pots, planter-lining mats, plant fences, and root and shoot barriers. No chemical binders are used in the process. First, the plant material is chopped into smaller particles. The particles are leached with water or steam to remove material that can inhibit plant growth, yielding a fibrous slurry. If the desired structures are plugs or sheets, then the slurry is formed into the desired shapes in a pulp molding subprocess. If the desired structures are root and shoot barriers, pots, or fences, then the slurry is compression-molded to the desired shapes in a heated press. The processed materials in these structures have properties similar to those of commercial pressboard, but unlike pressboard, these materials contain no additives. These structures have been found to withstand one growth cycle, even when wet

  14. Radiators in hydronic heating installations structure, selection and thermal characteristics

    CERN Document Server

    Muniak, Damian Piotr

    2017-01-01

    This book addresses key design and computational issues related to radiators in hydronic heating installations. A historical outline is included to highlight the evolution of radiators and heating technologies. Further, the book includes a chapter on thermal comfort, which is the decisive factor in selecting the ideal heating system and radiator type. The majority of the book is devoted to an extensive discussion of the types and kinds of radiators currently in use, and to identifying the reasons for the remarkable diversity of design solutions. The differences between the solutions are also addressed, both in terms of the effects of operation and of the thermal comfort that needs to be ensured. The book then compares the advantages and disadvantages of each solution, as well as its potential applications. A detailed discussion, supported by an extensive theoretical and mathematical analysis, is presented of the computational relations that are used in selecting the radiator type. The dynamics of radiator hea...

  15. SELECTIVE HYDROGENATION OF CINNAMALDEHYDE WITH Pt AND Pt-Fe CATALYSTS: EFFECTS OF THE SUPPORT

    Directory of Open Access Journals (Sweden)

    A.B. da Silva

    1998-06-01

    Full Text Available Low-temperature reduced TiO2-supported Pt and Pt-Fe catalysts are much more active and selective for the liquid–phase hydrogenation of cinnamaldehyde to unsaturated cinnamyl alcohol than the corresponding carbon-supported catalysts. High-temperature reduced catalysts, where the SMSI effect should be present, are almost inactive for this reaction. There is at present no definitive explanation for this effect but an electronic metal-support interaction is most probably involved.

  16. Innovating science communication: the structure supporting ATLAS Education & Outreach

    Science.gov (United States)

    Goldfarb, Steven; Marcelloni, Claudia; Shaw, Kate; ATLAS Experiment

    2016-04-01

    The ATLAS Education & Outreach project has, over the years, developed a strong reputation for supporting innovation. Animated event displays, musical CDs, 3d movies, 3-storey murals, photo books, data sonifications, multi-media art installations, pub slams, masterclasses, documentaries, pop-up books, LEGO® models, and virtual visits are among the many diverse methods being exploited to communicate to the world the goals and accomplishments of the ATLAS Experiment at CERN. This variety of creativity and innovation does not pop out of a vacuum. It requires underlying motivation by the collaboration to communicate with the public; freedom and encouragement to do so in a creative manner; and a support structure for developing, implementing and promoting these activities. The ATLAS Outreach project has built this support structure on a well-defined communication plan, high-quality content, and effective delivery platforms. Most importantly, implementation of the program has been based on the effective engagement of the participating institutes and other key partners, not only to leverage modest human resources and funding, but also to take advantage of the rich imagination and inspiration of a diverse, global human collaboration. We present our current plan, on-going activities, and a few more fun innovations for the future.

  17. Ancestral informative marker selection and population structure visualization using sparse Laplacian eigenfunctions.

    Directory of Open Access Journals (Sweden)

    Jun Zhang

    Full Text Available Identification of a small panel of population structure informative markers can reduce genotyping cost and is useful in various applications, such as ancestry inference in association mapping, forensics and evolutionary theory in population genetics. Traditional methods to ascertain ancestral informative markers usually require the prior knowledge of individual ancestry and have difficulty for admixed populations. Recently Principal Components Analysis (PCA has been employed with success to select SNPs which are highly correlated with top significant principal components (PCs without use of individual ancestral information. The approach is also applicable to admixed populations. Here we propose a novel approach based on our recent result on summarizing population structure by graph laplacian eigenfunctions, which differs from PCA in that it is geometric and robust to outliers. Our approach also takes advantage of the priori sparseness of informative markers in the genome. Through simulation of a ring population and the real global population sample HGDP of 650K SNPs genotyped in 940 unrelated individuals, we validate the proposed algorithm at selecting most informative markers, a small fraction of which can recover the similar underlying population structure efficiently. Employing a standard Support Vector Machine (SVM to predict individuals' continental memberships on HGDP dataset of seven continents, we demonstrate that the selected SNPs by our method are more informative but less redundant than those selected by PCA. Our algorithm is a promising tool in genome-wide association studies and population genetics, facilitating the selection of structure informative markers, efficient detection of population substructure and ancestral inference.

  18. The Choice Is Yours: The Role of Cognitive Processes for IT-Supported Idea Selection

    DEFF Research Database (Denmark)

    Seeber, Isabella; Weber, Barbara; Maier, Ronald

    2018-01-01

    of selection direction and selection type. A laboratory experiment using eye-tracking will investigate variations in selection type and selection direction. Moreover, the experiment will test the effects on the decision-making process and the number and quality of ideas in a filtered set. Findings will provide......The selection of good ideas out of hundreds or even thousands has proven to be the next big challenge for organizations that conduct open idea contests for innovation. Cognitive load and attention loss hinder crowds to effectively run their idea selection process. Facilitation techniques...... for the reduction and clarification of ideas could help with such problems, but have not yet been researched in crowd settings that are prevalent in idea contests. This research-in-progress paper aims to contribute to this research gap by investigating IT-supported selection techniques that differ in terms...

  19. Parameter Selection Method for Support Vector Regression Based on Adaptive Fusion of the Mixed Kernel Function

    Directory of Open Access Journals (Sweden)

    Hailun Wang

    2017-01-01

    Full Text Available Support vector regression algorithm is widely used in fault diagnosis of rolling bearing. A new model parameter selection method for support vector regression based on adaptive fusion of the mixed kernel function is proposed in this paper. We choose the mixed kernel function as the kernel function of support vector regression. The mixed kernel function of the fusion coefficients, kernel function parameters, and regression parameters are combined together as the parameters of the state vector. Thus, the model selection problem is transformed into a nonlinear system state estimation problem. We use a 5th-degree cubature Kalman filter to estimate the parameters. In this way, we realize the adaptive selection of mixed kernel function weighted coefficients and the kernel parameters, the regression parameters. Compared with a single kernel function, unscented Kalman filter (UKF support vector regression algorithms, and genetic algorithms, the decision regression function obtained by the proposed method has better generalization ability and higher prediction accuracy.

  20. MASS TRANSFER IN PORE STRUCTURES OF SUPPORTED CATALYSTS

    Directory of Open Access Journals (Sweden)

    F.R.C. Silva

    1997-09-01

    Full Text Available The effects of gas-solid interaction and mass transfer in fixed-bed systems of supported catalysts were analyzed for g -Al2O3 (support and Cu/g -Al2O3 (catalyst systems. Evaluations of the mass transfer coefficients in the macropores and of the diffusivity in the micropores, as formed by the crystallite agglomerates of the metallic phases, were obtained. Dynamic experiments with gaseous tracers permitted the quantification of the parameters based on models for these two pore structures. With a flow in a range of 18 cm3 s-1 to 39.98 cm3 s-1 at 45oC, 65oC and 100oC, mass transfer coefficients km =4.33x10-4 m s-1 to 7.38x10-4 m s-1 for macropore structures and diffusivities Dm =1.29x10-11 m2 s-1 to 5.35x10-11 m2 s-1 for micropore structures were estimated

  1. The Mixed Waste Management Facility: Technology selection and implementation plan, Part 2, Support processes

    International Nuclear Information System (INIS)

    Streit, R.D.; Couture, S.A.

    1995-03-01

    The purpose of this document is to establish the foundation for the selection and implementation of technologies to be demonstrated in the Mixed Waste Management Facility, and to select the technologies for initial pilot-scale demonstration. Criteria are defined for judging demonstration technologies, and the framework for future technology selection is established. On the basis of these criteria, an initial suite of technologies was chosen, and the demonstration implementation scheme was developed. Part 1, previously released, addresses the selection of the primary processes. Part II addresses process support systems that are considered ''demonstration technologies.'' Other support technologies, e.g., facility off-gas, receiving and shipping, and water treatment, while part of the integrated demonstration, use best available commercial equipment and are not selected against the demonstration technology criteria

  2. Structure coefficients and strategy selection in multiplayer games.

    Science.gov (United States)

    McAvoy, Alex; Hauert, Christoph

    2016-01-01

    Evolutionary processes based on two-player games such as the Prisoner's Dilemma or Snowdrift Game are abundant in evolutionary game theory. These processes, including those based on games with more than two strategies, have been studied extensively under the assumption that selection is weak. However, games involving more than two players have not received the same level of attention. To address this issue, and to relate two-player games to multiplayer games, we introduce a notion of reducibility for multiplayer games that captures what it means to break down a multiplayer game into a sequence of interactions with fewer players. We discuss the role of reducibility in structured populations, and we give examples of games that are irreducible in any population structure. Since the known conditions for strategy selection, otherwise known as [Formula: see text]-rules, have been established only for two-player games with multiple strategies and for multiplayer games with two strategies, we extend these rules to multiplayer games with many strategies to account for irreducible games that cannot be reduced to those simpler types of games. In particular, we show that the number of structure coefficients required for a symmetric game with [Formula: see text]-player interactions and [Formula: see text] strategies grows in [Formula: see text] like [Formula: see text]. Our results also cover a type of ecologically asymmetric game based on payoff values that are derived not only from the strategies of the players, but also from their spatial positions within the population.

  3. ASH structure alignment package: Sensitivity and selectivity in domain classification

    Directory of Open Access Journals (Sweden)

    Toh Hiroyuki

    2007-04-01

    Full Text Available Abstract Background Structure alignment methods offer the possibility of measuring distant evolutionary relationships between proteins that are not visible by sequence-based analysis. However, the question of how structural differences and similarities ought to be quantified in this regard remains open. In this study we construct a training set of sequence-unique CATH and SCOP domains, from which we develop a scoring function that can reliably identify domains with the same CATH topology and SCOP fold classification. The score is implemented in the ASH structure alignment package, for which the source code and a web service are freely available from the PDBj website http://www.pdbj.org/ASH/. Results The new ASH score shows increased selectivity and sensitivity compared with values reported for several popular programs using the same test set of 4,298,905 structure pairs, yielding an area of .96 under the receiver operating characteristic (ROC curve. In addition, weak sequence homologies between similar domains are revealed that could not be detected by BLAST sequence alignment. Also, a subset of domain pairs is identified that exhibit high similarity, even though their CATH and SCOP classification differs. Finally, we show that the ranking of alignment programs based solely on geometric measures depends on the choice of the quality measure. Conclusion ASH shows high selectivity and sensitivity with regard to domain classification, an important step in defining distantly related protein sequence families. Moreover, the CPU cost per alignment is competitive with the fastest programs, making ASH a practical option for large-scale structure classification studies.

  4. Vessel supporting structure for liquid metal cooled nuclear reactors

    International Nuclear Information System (INIS)

    Mahe, Armel; Jullien, Georges

    1974-01-01

    The supporting structure described is for a liquid metal cooled nuclear reactor, the vessel being of the type suspended to the end slab of the reactor. It includes a ring connected at one of its two ends to a single shell and at the other end to two shells. One of these three shells connected to the lower end of the ring forms the upper part of the vessel to be supported. The two other shells are embedded in two sperate parts of the slab. The ring and shell assembly is housed in an annular space provided in the end slab and separating it into two parts, namely a central part and a peripheral part [fr

  5. Structural support system for a superconducting magnet coil

    International Nuclear Information System (INIS)

    Meuser, R.B.

    1977-01-01

    The purpose of the ESCAR (Experimental Superconducting Accelerator Ring) project, now under way at the Lawrence Berkeley Laboratory, is to gather data and experience in the design and operation of a relatively small synchrotron employing superconducting magnets. Such data are essential to ensure that the design of future large accelerators may proceed in a knowledgeable and responsible manner. One of the many engineering problems associated with a superconducting magnet is the design of the coil suspension system. The coil, maintained at the temperature of liquid helium, must be held rigidly by a structure that does not conduct too much heat into the liquid helium system. The suspension system used on the ESCAR magnets is described. Topics covered include the coil support system requirements, ESCAR magnet support system, and operating experience

  6. Structural analysis of Wendelstein 7-X magnet weight supports

    International Nuclear Information System (INIS)

    Egorov, Konstantin; Bykov, Victor; Schauer, Felix; van Eeten, Paul

    2009-01-01

    The Wendelstein 7-X (W7-X) optimized stellarator is presently under construction at the Max-Planck-Institut fuer Plasmaphysik in Greifswald. The goal of W7-X is to verify that the advanced stellarator magnetic confinement concept is a viable option for a fusion reactor. The W7-X coil system consisting of 70 superconducting coils of seven different types is supported by a massive central support structure (CSS), and thermally protected by the cryostat. The magnet system's weight is borne by supports (cryo-legs) which are bolted to the cold CSS. They reach down through the cryostat wall to the warm machine base which means that a small thermal conductivity is important to keep thermal losses at an acceptable level. Therefore, the design of the cryo-legs incorporates glass-reinforced plastic (GRP) tubes which are shrink-fitted into stainless steel flanges at the ends. In order to ensure free thermal shrinkage of the magnet system and to reduce stresses in the cryo-legs, sliding and rotating bearings are used as interfaces to the machine base. Tie rods between the machine base and the warm ends of the cryo-legs prevent toroidal movements of the magnet system with respect to the torus axis. Nevertheless, significant deformation of the CSS during operation results in tilting of the cryo-legs in such a way that toroidal movements of the whole magnet system take place. The number of cryo-legs and their stiffness are chosen such that the toroidal movement is kept within an acceptable range. All these restrictions, as well as requirements concerning simplicity and ease of assembly, make the cryo-leg design and structural analysis quite a complex and challenging task. The paper presents an overview of structural analyses of the W7-X magnet system with cryo-legs, local analyses of a cryo-leg under design loads, and FE simulation of the cryo-leg mechanical test.

  7. Data structures supporting multi-region adaptive isogeometric analysis

    Science.gov (United States)

    Perduta, Anna; Putanowicz, Roman

    2018-01-01

    Since the first paper published in 2005 Isogeometric Analysis (IGA) has gained strong interest and found applications in many engineering problems. Despite the advancement of the method, there are still far fewer software implementations comparing to Finite Element Method. The paper presents an approach to the development of data structures that can support multi-region IGA with local mesh refinement (patch-based) and possible application in IGA-FEM models. The purpose of this paper is to share original design concepts, that authors have created while developing an IGA package, which other researchers may find beneficial for their own simulation codes.

  8. Structural basis for AMPA receptor activation and ligand selectivity

    DEFF Research Database (Denmark)

    Hogner, A; Kastrup, Jette Sandholm Jensen; Jin, R

    2002-01-01

    Glutamate is the principal excitatory neurotransmitter within the mammalian CNS, playing an important role in many different functions in the brain such as learning and memory. In this study, a combination of molecular biology, X-ray structure determinations, as well as electrophysiology...... with Br-HIBO and ACPA have allowed us to explain the molecular mechanism behind this selectivity and to identify key residues for ligand recognition. The agonists induce the same degree of domain closure as AMPA, except for Br-HIBO, which shows a slightly lower degree of domain closure. An excellent...

  9. Structural adaptations to diverse fighting styles in sexually selected weapons.

    Science.gov (United States)

    McCullough, Erin L; Tobalske, Bret W; Emlen, Douglas J

    2014-10-07

    The shapes of sexually selected weapons differ widely among species, but the drivers of this diversity remain poorly understood. Existing explanations suggest weapon shapes reflect structural adaptations to different fighting styles, yet explicit tests of this hypothesis are lacking. We constructed finite element models of the horns of different rhinoceros beetle species to test whether functional specializations for increased performance under species-specific fighting styles could have contributed to the diversification of weapon form. We find that horns are both stronger and stiffer in response to species-typical fighting loads and that they perform more poorly under atypical fighting loads, which suggests weapons are structurally adapted to meet the functional demands of fighting. Our research establishes a critical link between weapon form and function, revealing one way male-male competition can drive the diversification of animal weapons.

  10. An Optimization Model For Strategy Decision Support to Select Kind of CPO’s Ship

    Science.gov (United States)

    Suaibah Nst, Siti; Nababan, Esther; Mawengkang, Herman

    2018-01-01

    The selection of marine transport for the distribution of crude palm oil (CPO) is one of strategy that can be considered in reducing cost of transport. The cost of CPO’s transport from one area to CPO’s factory located at the port of destination may affect the level of CPO’s prices and the number of demands. In order to maintain the availability of CPO a strategy is required to minimize the cost of transporting. In this study, the strategy used to select kind of charter ships as barge or chemical tanker. This study aims to determine an optimization model for strategy decision support in selecting kind of CPO’s ship by minimizing costs of transport. The select of ship was done randomly, so that two-stage stochastic programming model was used to select the kind of ship. Model can help decision makers to select either barge or chemical tanker to distribute CPO.

  11. NegGOA: negative GO annotations selection using ontology structure.

    Science.gov (United States)

    Fu, Guangyuan; Wang, Jun; Yang, Bo; Yu, Guoxian

    2016-10-01

    Predicting the biological functions of proteins is one of the key challenges in the post-genomic era. Computational models have demonstrated the utility of applying machine learning methods to predict protein function. Most prediction methods explicitly require a set of negative examples-proteins that are known not carrying out a particular function. However, Gene Ontology (GO) almost always only provides the knowledge that proteins carry out a particular function, and functional annotations of proteins are incomplete. GO structurally organizes more than tens of thousands GO terms and a protein is annotated with several (or dozens) of these terms. For these reasons, the negative examples of a protein can greatly help distinguishing true positive examples of the protein from such a large candidate GO space. In this paper, we present a novel approach (called NegGOA) to select negative examples. Specifically, NegGOA takes advantage of the ontology structure, available annotations and potentiality of additional annotations of a protein to choose negative examples of the protein. We compare NegGOA with other negative examples selection algorithms and find that NegGOA produces much fewer false negatives than them. We incorporate the selected negative examples into an efficient function prediction model to predict the functions of proteins in Yeast, Human, Mouse and Fly. NegGOA also demonstrates improved accuracy than these comparing algorithms across various evaluation metrics. In addition, NegGOA is less suffered from incomplete annotations of proteins than these comparing methods. The Matlab and R codes are available at https://sites.google.com/site/guoxian85/neggoa gxyu@swu.edu.cn Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  12. Design and structural analysis of support structure for ITER vacuum vessel

    International Nuclear Information System (INIS)

    Takeda, Nobukazu; Ohmori, Junji; Nakahira, Masataka; Shibanuma, Kiyoshi

    2004-01-01

    The International Thermonuclear Experimental Reactor (ITER) vacuum vessel (VV) is a safety component confining radioactive materials such as tritium and activated dust. An independent VV support structure with multiple flexible plates located at the bottom of VV lower port is proposed as a new concept, which is deferent from the current design, i.e., the VV support is directly connected to the toroidal coils (TF coils). This independent concept has two advantages comparing to the current one: (1) thermal load due to the temperature deference between VV and TF coils becomes lower and (2) the TF coils are categorized as non-safety components because of its independence from VV. Stress Analyses have been performed to assess the integrity of the VV support structure using a precisely modeled VV structure. As a result, (1) the maximum displacement of the VV corresponding to the relative displacement between VV and TF coils is found to be 15 mm, much less than the current design clearance of 100 mm, and (2) the stresses of the whole VV system including VV support are estimated to be less than the allowable ones defined by ASME Section III Subsection NF, respectively. Based on these assessments, the feasibility of the proposed independent VV support has been verified as a VV support. (author)

  13. Using support vector machines to improve elemental ion identification in macromolecular crystal structures

    Energy Technology Data Exchange (ETDEWEB)

    Morshed, Nader [University of California, Berkeley, CA 94720 (United States); Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Echols, Nathaniel, E-mail: nechols@lbl.gov [Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Adams, Paul D., E-mail: nechols@lbl.gov [Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); University of California, Berkeley, CA 94720 (United States)

    2015-05-01

    A method to automatically identify possible elemental ions in X-ray crystal structures has been extended to use support vector machine (SVM) classifiers trained on selected structures in the PDB, with significantly improved sensitivity over manually encoded heuristics. In the process of macromolecular model building, crystallographers must examine electron density for isolated atoms and differentiate sites containing structured solvent molecules from those containing elemental ions. This task requires specific knowledge of metal-binding chemistry and scattering properties and is prone to error. A method has previously been described to identify ions based on manually chosen criteria for a number of elements. Here, the use of support vector machines (SVMs) to automatically classify isolated atoms as either solvent or one of various ions is described. Two data sets of protein crystal structures, one containing manually curated structures deposited with anomalous diffraction data and another with automatically filtered, high-resolution structures, were constructed. On the manually curated data set, an SVM classifier was able to distinguish calcium from manganese, zinc, iron and nickel, as well as all five of these ions from water molecules, with a high degree of accuracy. Additionally, SVMs trained on the automatically curated set of high-resolution structures were able to successfully classify most common elemental ions in an independent validation test set. This method is readily extensible to other elemental ions and can also be used in conjunction with previous methods based on a priori expectations of the chemical environment and X-ray scattering.

  14. Tuning the Electronic Structure of Titanium Oxide Support to Enhance the Electrochemical Activity of Platinum Nanoparticles

    KAUST Repository

    Shi, Feifei

    2013-09-11

    Two times higher activity and three times higher stability in methanol oxidation reaction, a 0.12 V negative shift of the CO oxidation peak potential, and a 0.07 V positive shift of the oxygen reaction potential compared to Pt nanoparticles on pristine TiO2 support were achieved by tuning the electronic structure of the titanium oxide support of Pt nanoparticle catalysts. This was accomplished by adding oxygen vacancies or doping with fluorine. Experimental trends are interpreted in the context of an electronic structure model, showing an improvement in electrochemical activity when the Fermi level of the support material in Pt/TiOx systems is close to the Pt Fermi level and the redox potential of the reaction. The present approach provides guidance for the selection of the support material of Pt/TiOx systems and may be applied to other metal-oxide support materials, thus having direct implications in the design and optimization of fuel cell catalyst supports. © 2013 American Chemical Society.

  15. The age structure of selected countries in the ESCAP region.

    Science.gov (United States)

    Hong, S

    1982-01-01

    The study objective was to examine the age structure of selected countries in the Economic and Social Commission for Asia and the Pacific (ESCAP) region, using available data and frequently applied indices such as the population pyramid, aged-child ratio, and median age. Based on the overall picture of the age structure thus obtained, age trends and their implication for the near future were arrived at. Countries are grouped into 4 types based on the fertility and mortality levels. Except for Japan, Hong Kong, and Singapore, the age structure in the 18 ESCAP region countries changed comparatively little over the 1950-80 period. The largest structural change occurred in Singapore, where the proportion of children under age 15 in the population declined significantly from 41-27%, while that of persons 65 years and older more than doubled. This was due primarily to the marked decline in fertility from a total fertility rate (TFR) of 6.7-1.8 during the period. Hong Kong also had a similar major transformation during the same period: the proportion of the old age population increased 2 1/2 times, from 2.5-6.3%. The age structures of the 18 ESCAP countries varied greatly by country. 10 countries of the 2 high fertility and mortality types showed a similar young age structural pattern, i.e., they have higher dependency ratios, a higher proportion of children under 15 years, a lower proportion of population 65 years and older, lower aged-child ratios, and younger median ages than the average countries in the less developed regions of the world. With minimal changes over the 1950-80 period, the gap between these countries and the average of the less developed regions widened. Unlike these 10 (mostly South Asian) countries, moderately low fertility and mortality countries (China, Korea, and Sri Lanka) are located between the world average and the less developed region in most of the indices, particularly during the last decade. Although their rate of population aging is not

  16. Structural analysis under the Blanket Comparison and Selection Study

    International Nuclear Information System (INIS)

    Majumdar, S.

    1985-01-01

    Structural design procedures followed in the Blanket Comparison and Selection Study are briefly reviewed. The American Society of Mechanical Engineers Boilers and Pressure Vessels Code, Section III, Code Case N47 has been used as a design guide. Its relevance to fusion reactor applications, however, is open to question and needs to be evaluated in the future. The primary structural problem encountered in tokamak blanket designs is the high thermal stress due to surface heat flux, with fatigue being an additional concern for pulsed systems. The conflicting requirements of long erosion life and high surface heat flux capability imply that some form of stress relief in the first-wall region will be necessary. Simplified stress and fatigue crack growth analyses are presented to show that the use of orthogonally grooved first wall may be a potential solution for mitigating the thermal stress problem. A comparison of three structural alloys on the basis of both grooved and nongrooved first-wall designs is also presented. Other structural problems encountered in tokamak designs include stresses due to plasma disruptions, and magnetohydrodynamic (MHD) pressure drop in liquid-metal-cooled systems. In particular, it is shown that the maximum stress in the side wall of a uniform duct generated by MHD pressure drop cannot be reduced by increasing the wall thickness or by decreasing the span. In contract to tokamak blankets, tandem mirror blankets are far less severely stressed because of a much lower surface heat flux, coolant pressure, and also because of their axisymmetric geometry. Both blankets, however, will require detailed structural dynamics analysis to verify their ability to withstand seismic loadings if the heavy 17Li-83Pb is used as a coolant

  17. Software development to support decision making in the selection of nursing diagnoses and interventions for children and adolescents.

    Science.gov (United States)

    Silva, Kenya de Lima; Évora, Yolanda Dora Martinez; Cintra, Camila Santana Justo

    2015-01-01

    to report the development of a software to support decision-making for the selection of nursing diagnoses and interventions for children and adolescents, based on the nomenclature of nursing diagnoses, outcomes and interventions of a university hospital in Paraiba. a methodological applied study based on software engineering, as proposed by Pressman, developed in three cycles, namely: flow chart construction, development of the navigation interface, and construction of functional expressions and programming development. the software consists of administrative and nursing process screens. The assessment is automatically selected according to age group, the nursing diagnoses are suggested by the system after information is inserted, and can be indicated by the nurse. The interventions for the chosen diagnosis are selected by structuring the care plan. the development of this tool used to document the nursing actions will contribute to decision-making and quality of care.

  18. Software development to support decision making in the selection of nursing diagnoses and interventions for children and adolescents

    Directory of Open Access Journals (Sweden)

    Kenya de Lima Silva

    2015-10-01

    Full Text Available Objective: to report the development of a software to support decision-making for the selection of nursing diagnoses and interventions for children and adolescents, based on the nomenclature of nursing diagnoses, outcomes and interventions of a university hospital in Paraiba.Method: a methodological applied study based on software engineering, as proposed by Pressman, developed in three cycles, namely: flow chart construction, development of the navigation interface, and construction of functional expressions and programming development.Result: the software consists of administrative and nursing process screens. The assessment is automatically selected according to age group, the nursing diagnoses are suggested by the system after information is inserted, and can be indicated by the nurse. The interventions for the chosen diagnosis are selected by structuring the care plan.Conclusion: the development of this tool used to document the nursing actions will contribute to decision-making and quality of care.

  19. Sol-gel synthesis of iron catalysers supported on silica and titanium for selectively oxidising methane to formaldehyde

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Guerrero Fajardo

    2008-01-01

    Full Text Available Iron materials supported on silica were prepared by the sol-gel method for evaluating catalytic activity in selective o-xidation of methane to formaldehyde. Four catalysts were prepared, one corresponding to the silica support (catalyst 1S, another to the titanium support (catalyst 1T and two more having 0.5% weight iron loads, one for the silica su-pport (catalyst 2FS and the last one the titanium support (catalyst 2FT. The higher BET areas were 659 and 850 m2/g for catalysts 1S and 2FS, respectively while catalysts 1T and 2FT displayed areas of 65 and 54 m2/g, respec-tively. Scanning and transmission electronic microscopy displayed an amorphous structure in the silica-supported materials while titanium-supported materials displayed dense materials having defined structure. X-ray diffraction confirmed the silica’s amorphous structure in 1S and 2FS catalysts and displayed the 1T and 2FT catalysts’ anatase structure. The programmed temperature reduction for the 1S and 2FS catalysts did not display reducible species, while displaying hydrogen consumption peaks related to Fe3O4 reduction to α-Fe via FexO route for 1T and 2FT ca-talysts. The electronic spectroscopy X-ray photo confirmed the Fe(III specie as having 710.6 e.V binding energy for both 2FS and 2FT catalysts. Catalytic activity was carried out at atmospheric pressure in a quartz reactor, reaction mixture as CH4/O2/N2 =7.5/1/4 at 400-800°C temperature range. The reaction products were analysed by gas chromatography on Hayesep R and T columns using 5Å molecular screening. The best response for selective oxida-tion of methane to formaldehyde was displayed by the 2FS catalyst with 3.4% mol methane conversion at 650°C, 11.9% mol formaldehyde selectivity and 0.0211 g HCHO/Kg catalyst yield.

  20. An information offering system for operation support based on plant functional structure

    International Nuclear Information System (INIS)

    Ohga, Yukiharu; Seki, Hiroshi

    1995-01-01

    A plant information offering system was proposed to support operators in their selection and confirmation of the required information for plant operation under transient conditions in nuclear power plants. The system features include an automatic selection method for information and a dialog input method. The former selects plant information in response to plant status changes and operators' demands. The selection is performed based on the knowledge and data as structured by the plant functional structure; i.e. a means-ends abstraction hierarchy model. In the latter, both speech and CRT touch inputs are transformed into words in Japanese to realize an arbitrary input mode combination. The words are analyzed as a sentence before transforming them into a demand for related programs. A prototype system was evaluated using a BWR simulator, assuming abnormal transients such as loss of feedwater. The contents of the offered information were checked based on emergency operation guidelines. It was confirmed that appropriate information items are automatically selected in real time. Answers are generated in reply to the operators' demands. They include information added to reflect the plant conditions. As for dialog, simple and quick input is realized by combining speech and CRT touch according to the operating situation. (author)

  1. Proposed Project Selection Method for Human Support Research and Technology Development (HSR&TD)

    Science.gov (United States)

    Jones, Harry

    2005-01-01

    The purpose of HSR&TD is to deliver human support technologies to the Exploration Systems Mission Directorate (ESMD) that will be selected for future missions. This requires identifying promising candidate technologies and advancing them in technology readiness until they are acceptable. HSR&TD must select an may of technology development projects, guide them, and either terminate or continue them, so as to maximize the resulting number of usable advanced human support technologies. This paper proposes an effective project scoring methodology to support managing the HSR&TD project portfolio. Researchers strongly disagree as to what are the best technology project selection methods, or even if there are any proven ones. Technology development is risky and outstanding achievements are rare and unpredictable. There is no simple formula for success. Organizations that are satisfied with their project selection approach typically use a mix of financial, strategic, and scoring methods in an open, established, explicit, formal process. This approach helps to build consensus and develop management insight. It encourages better project proposals by clarifying the desired project attributes. We propose a project scoring technique based on a method previously used in a federal laboratory and supported by recent research. Projects are ranked by their perceived relevance, risk, and return - a new 3 R's. Relevance is the degree to which the project objective supports the HSR&TD goal of developing usable advanced human support technologies. Risk is the estimated probability that the project will achieve its specific objective. Return is the reduction in mission life cycle cost obtained if the project is successful. If the project objective technology performs a new function with no current cost, its return is the estimated cash value of performing the new function. The proposed project selection scoring method includes definitions of the criteria, a project evaluation

  2. Decision support model for selecting and evaluating suppliers in the construction industry

    Directory of Open Access Journals (Sweden)

    Fernando Schramm

    2012-12-01

    Full Text Available A structured evaluation of the construction industry's suppliers, considering aspects which make their quality and credibility evident, can be a strategic tool to manage this specific supply chain. This study proposes a multi-criteria decision model for suppliers' selection from the construction industry, as well as an efficient evaluation procedure for the selected suppliers. The model is based on SMARTER (Simple Multi-Attribute Rating Technique Exploiting Ranking method and its main contribution is a new approach to structure the process of suppliers' selection, establishing explicit strategic policies on which the company management system relied to make the suppliers selection. This model was applied to a Civil Construction Company in Brazil and the main results demonstrate the efficiency of the proposed model. This study allowed the development of an approach to Construction Industry which was able to provide a better relationship among its managers, suppliers and partners.

  3. Earthquake-proof supporting structure in reactor vessel

    International Nuclear Information System (INIS)

    Sakurai, Akio; Sekine, Katsuhisa; Madokoro, Manabu; Katoono, Shin-ichi; Konno, Mutsuo; Suzuki, Takuro.

    1990-01-01

    Conventional earthquake-proof structure comprises a vessel vibration stopper integrated to a reactor vessel, powder for restricting the horizontal displacements, a safety vessel surrounds the outer periphery of the reactor vessel and a safety vessel vibration stopper integrated therewith, which are fixed to buildings. However, there was a problem that a great amount of stresses are generated in the base of the reactor vessel vibration stopper due to reaction of the powders which restrict thermal expansion. In order to remarkably reduce the reaction of the powers, powders are charged into a spaces formed between each of the reactor vessel vibration stopper, the safety vessel vibration stopper and the flexible member disposed between them. According to this constitution, the reactor vessel vibration stopper does not undergo a great reaction of the powers upon thermal expansion of the reactor vessel to moderate the generated stresses, maintain the strength and provide earthquake-proof supporting function. (N.H.)

  4. Validation of spectral methods for the seismic analysis of multi-supported structures

    International Nuclear Information System (INIS)

    Viola, B.

    1999-01-01

    There are many methodologies for the seismic analysis of buildings. When a seism occurs, structures such piping systems in nuclear power plants are subjected to motions that may be different at each support point. Therefore it is necessary to develop methods that take into account the multi-supported effect. In a first time, a bibliography analysis on the different methods that exist has been carried out. The aim was to find a particular method applicable to the study of piping systems. The second step of this work consisted in developing a program that may be used to test and make comparisons on different selected methods. So spectral methods have the advantage to give an estimation of the maximum values for strain in the structure, in reduced calculation time. The time history analysis is used as the reference for the tests. (author)

  5. A Diagnostic Decision Support System for BMP Selection in Small Urban Watersheds

    Science.gov (United States)

    Wang, Y.; Montas, H. J.; Leisnham, P.; Shirmohammadi, A.; Brubaker, K. L.; Reiling, S.

    2013-12-01

    Overall water quality in the United States has improved since the establishment of the Clean Water Act in 1972. While waste water and other point source discharge treatments are expanding and improving in quality, non-point source pollution remains a problem. Best Management Practices (BMPs) are structural and nonstructural methods to mitigate these problems. Much attention has focused on non-point source pollutants in rural areas, where agricultural activities increase the nutrients (fertilizers), toxics (pesticides), and sediments in surface water. Urban and suburban areas also suffer from severe water quantity and quality problems, largely due to stormwater. Low Impact Development (LID), a series of spatially distributed and engineered small-scale hydrologic controls, is an appropriate approach to reduce flow rate and improve urban stormwater quality before it discharges into surface water bodies. This research sought to develop a Diagnostic Decision Support System (DDSS) for urban BMP/LID selection. The process-based hydrologic model, Soil and Water Assessment Tool (SWAT), was used to simulate the hydrologic processes and to estimate related water quality variables. A logic based simple method was developed to identify the critical water quality and quantity hotspots using the SWAT outputs for multiple Hydrologic Response Units (HRUs) within the study watershed. The DDSS consisted of two parts: a Diagnostic Expert System (DES), which identifies the most likely reasons for excessive pollutants; and a Prescriptive Expert System (PES), which selects the best set of spatially distributed BMPs. The DDSS is tested in Watts Branch, a small urban subwatershed in metropolitan Washington D.C. A SWAT model for the watershed was calibrated and validated first. The DDSS was then applied. The final selected series of BMPs was simulated again in the SWAT model for a ten-year period to quantify their effectiveness. The identified hotspots, possible reasons, and BMP solutions

  6. Supporting and structuring "contributing student pedagogy" in Computer Science curricula

    Science.gov (United States)

    Falkner, Katrina; Falkner, Nickolas J. G.

    2012-12-01

    Contributing student pedagogy (CSP) builds upon social constructivist and community-based learning principles to create engaging and productive learning experiences. What makes CSP different from other, related, learning approaches is that it involves students both learning from and also explicitly valuing the contributions of other students. The creation of such a learning community builds upon established educational psychology that encourages deep learning, reflection and engagement. Our school has recently completed a review and update of its curriculum, incorporating student content-creation and collaboration into the design of key courses across the curriculum. Our experiences, based on several years of experimentation and development, support CSP-based curriculum design to reinforce the value of the student perspective, the clear description of their own transformative pathway to knowledge and the importance of establishing student-to-student networks in which students are active and willing participants. In this paper, we discuss the tools and approaches that we have employed to guide, support and structure student collaboration across a range of courses and year levels. By providing an account of our intentions, our approaches and tools, we hope to provide useful and transferrable knowledge that can be readily used by other academics who are considering this approach.

  7. Evaluation of novel supports for selective and efficient enrichment of phosphorylated peptides

    CSIR Research Space (South Africa)

    Bensadek, D

    2011-06-01

    Full Text Available A series of novel emulsion based supports MagReSynTM TiO 2 (A-D) were evaluated using 32P labelled phosphopeptides and nano LC-MS/MS. The performance of MagReSynTM TiO 2 (D) was found to be significantly better in terms of selectivity and specificity...

  8. The Role of Language in the Selection of Entrepreneurial Opportunities for Societal Support

    NARCIS (Netherlands)

    Steinberg, Philip; Urbig, Diemo; Procher, Vivien D.; Dana, Leo-Paul

    2017-01-01

    The evaluation and selection of entrepreneurial opportunities for societal support often takes place in a global and, thereby, foreign language context. While previous research demonstrated that foreign language use influences individuals’ decision-making, our knowledge on the impact of foreign

  9. Highly Selective Continuous Gas-Phase Methoxycarbonylation of Ethylene with Supported Ionic Liquid Phase (SILP) Catalysts

    DEFF Research Database (Denmark)

    Khokarale, Santosh Govind; Garcia Suárez, Eduardo José; Fehrmann, Rasmus

    2017-01-01

    Supported ionic liquid phase (SILP) technology was applied for the first time to the Pd-catalyzed continuous, gas-phase methoxycarbonylation of ethylene to selectively produce methyl propanoate (MP) in high yields. The influence of catalyst and reaction parameters such as, for example, ionic liquid...

  10. Gold Supported on Graphene Oxide: An Active and Selective Catalyst for Phenylacetylene Hydrogenations at Low Temperatures

    DEFF Research Database (Denmark)

    Shao, Lidong; Huang, Xing; Teschner, Detre

    2014-01-01

    A constraint to industrial implementation of gold-catalyzed alkyne hydrogenation is that the catalytic activity was always inferior to those of other noble metals. In this work, gold was supported on graphene oxide (Au/GO) and used in a hydrogenation application. A 99% selectivity toward styrene...

  11. Selective Reduction of Nitrite to Nitrogen with Carbon-Supported Pd-AOT Nanoparticles

    NARCIS (Netherlands)

    Perez-Coronado, A. M.; Calvo, L.; Baeza, J.A.; Palomar, J.; Lefferts, L.; Rodriguez, J-C.; Gilarranz, M.A.

    2017-01-01

    The catalytic reduction of nitrite in water with hydrogen has been studied using a new strategy to control selectivity. The catalysts used are based on size-controlled Pd-AOT nanoparticles, synthesized via sodium bis[2-ethylhexyl] sulfosuccinate (AOT)/isooctane reverse microemulsion, supported on

  12. Unprecedented Selective Oxidation of Styrene Derivatives using a Supported Iron Oxide Nanocatalyst in Aqueous Medium

    Science.gov (United States)

    Iron oxide nanoparticles supported on mesoporous silica-type materials have been successfully utilized in the aqueous selective oxidation of alkenes under mild conditions using hydrogen peroxide as a green oxidant. Catalysts could be easily recovered after completion of the reac...

  13. Development of decision support system for employee selection using Adaptive Neuro Fuzzy Inference System

    Directory of Open Access Journals (Sweden)

    ‘Azzam Abdullah

    2018-01-01

    Full Text Available The number of children day care is increasing from year to year. Children day care is categorized as service industry that help parents in caring and educate children. This type of service industry plays a substitute for the family at certain hours, usually during work hours. The common problems in this industry is related to the employee performance. Most of employees have a less understanding about the whole job. Some employees only perform a routine task, i.e. feeding, cleaning and putting the child to sleep. The role in educating children is not performed as well as possible. Therefore, the employee selection is an important process to solve a children day care problem. An effective decision support system is required to optimize the employee selection process. Adaptive neuro fuzzy inference system (ANFIS is used to develop the decision support system for employee selection process. The data used to build the system is the historical data of employee selection process in children day care. The data shows the characteristic of job applicant that qualified and not qualified. From that data, the system can perform a learning process and give the right decision. The system is able to provide the right decision with an error of 0,00016249. It means that the decision support system that developed using ANFIS can give the right recommendation for employee selection process.

  14. Population structure, migration, and diversifying selection in the Netherlands

    Science.gov (United States)

    Abdellaoui, Abdel; Hottenga, Jouke-Jan; Knijff, Peter de; Nivard, Michel G; Xiao, Xiangjun; Scheet, Paul; Brooks, Andrew; Ehli, Erik A; Hu, Yueshan; Davies, Gareth E; Hudziak, James J; Sullivan, Patrick F; van Beijsterveldt, Toos; Willemsen, Gonneke; de Geus, Eco J; Penninx, Brenda W J H; Boomsma, Dorret I

    2013-01-01

    Genetic variation in a population can be summarized through principal component analysis (PCA) on genome-wide data. PCs derived from such analyses are valuable for genetic association studies, where they can correct for population stratification. We investigated how to capture the genetic population structure in a well-characterized sample from the Netherlands and in a worldwide data set and examined whether (1) removing long-range linkage disequilibrium (LD) regions and LD-based SNP pruning significantly improves correlations between PCs and geography and (2) whether genetic differentiation may have been influenced by migration and/or selection. In the Netherlands, three PCs showed significant correlations with geography, distinguishing between: (1) North and South; (2) East and West; and (3) the middle-band and the rest of the country. The third PC only emerged with minimized LD, which also significantly increased correlations with geography for the other two PCs. In addition to geography, the Dutch North–South PC showed correlations with genome-wide homozygosity (r=0.245), which may reflect a serial-founder effect due to northwards migration, and also with height (♂: r=0.142, ♀: r=0.153). The divergence between subpopulations identified by PCs is partly driven by selection pressures. The first three PCs showed significant signals for diversifying selection (545 SNPs - the majority within 184 genes). The strongest signal was observed between North and South for the functional SNP in HERC2 that determines human blue/brown eye color. Thus, this study demonstrates how to increase ancestry signals in a relatively homogeneous population and how those signals can reveal evolutionary history. PMID:23531865

  15. Spectroscopic evidence for origins of size and support effects on selectivity of Cu nanoparticle dehydrogenation catalysts.

    Science.gov (United States)

    Witzke, M E; Dietrich, P J; Ibrahim, M Y S; Al-Bardan, K; Triezenberg, M D; Flaherty, D W

    2017-01-03

    Selective dehydrogenation catalysts that produce acetaldehyde from bio-derived ethanol can increase the efficiency of subsequent processes such as C-C coupling over metal oxides to produce 1-butanol or 1,3-butadiene or oxidation to acetic acid. Here, we use in situ X-ray absorption spectroscopy and steady state kinetics experiments to identify Cu δ+ at the perimeter of supported Cu clusters as the active site for esterification and Cu 0 surface sites as sites for dehydrogenation. Correlation of dehydrogenation and esterification selectivities to in situ measures of Cu oxidation states show that this relationship holds for Cu clusters over a wide-range of diameters (2-35 nm) and catalyst supports and reveals that dehydrogenation selectivities may be controlled by manipulating either.

  16. A framework to support decision making in the selection of sustainable drainage system design alternatives.

    Science.gov (United States)

    Wang, Mingming; Sweetapple, Chris; Fu, Guangtao; Farmani, Raziyeh; Butler, David

    2017-10-01

    This paper presents a new framework for decision making in sustainable drainage system (SuDS) scheme design. It integrates resilience, hydraulic performance, pollution control, rainwater usage, energy analysis, greenhouse gas (GHG) emissions and costs, and has 12 indicators. The multi-criteria analysis methods of entropy weight and Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) were selected to support SuDS scheme selection. The effectiveness of the framework is demonstrated with a SuDS case in China. Indicators used include flood volume, flood duration, a hydraulic performance indicator, cost and resilience. Resilience is an important design consideration, and it supports scheme selection in the case study. The proposed framework will help a decision maker to choose an appropriate design scheme for implementation without subjectivity. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Assessing diabetes support in adolescents: factor structure of the Modified Diabetes Social Support Questionnaire (M-DSSQ-Family)

    NARCIS (Netherlands)

    Malik, J.A.; Koot, H.M.

    2011-01-01

    Objectives: To determine the underlying factor structure of diabetes specific support using a modified diabetes family social support questionnaire, the M-DSSQ-Family, in one half of a sample of adolescents with type 1 diabetes, confirm it in the second half, test invariance in factor structure

  18. Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors

    Czech Academy of Sciences Publication Activity Database

    Pachl, Petr; Fábry, Milan; Rosenberg, Ivan; Šimák, Ondřej; Řezáčová, Pavlína; Brynda, Jiří

    2014-01-01

    Roč. 70, February (2014), s. 461-470 ISSN 0907-4449 R&D Projects: GA ČR GA203/09/0820 Institutional support: RVO:68378050 ; RVO:61388963 Keywords : 5′(3′)-deoxyribonucleotidases * enzyme inhibition * hydrolases * structure-based drug design Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 7.232, year: 2013

  19. A Lightweight Structure Redesign Method Based on Selective Laser Melting

    Directory of Open Access Journals (Sweden)

    Li Tang

    2016-11-01

    Full Text Available The purpose of this paper is to present a new design method of lightweight parts fabricated by selective laser melting (SLM based on the “Skin-Frame” and to explore the influence of fabrication defects on SLM parts with different sizes. Some standard lattice parts were designed according to the Chinese GB/T 1452-2005 standard and manufactured by SLM. Then these samples were tested in an MTS Insight 30 compression testing machine to study the trends of the yield process with different structure sizes. A set of standard cylinder samples were also designed according to the Chinese GB/T 228-2010 standard. These samples, which were made of iron-nickel alloy (IN718, were also processed by SLM, and then tested in the universal material testing machine INSTRON 1346 to obtain their tensile strength. Furthermore, a lightweight redesigned method was researched. Then some common parts such as a stopper and connecting plate were redesigned using this method. These redesigned parts were fabricated and some application tests have already been performed. The compression testing results show that when the minimum structure size is larger than 1.5 mm, the mechanical characteristics will hardly be affected by process defects. The cylinder parts were fractured by the universal material testing machine at about 1069.6 MPa. These redesigned parts worked well in application tests, with both the weight and fabrication time of these parts reduced more than 20%.

  20. Tribological behavior of Ti6Al4V cellular structures produced by Selective Laser Melting.

    Science.gov (United States)

    Bartolomeu, F; Sampaio, M; Carvalho, O; Pinto, E; Alves, N; Gomes, J R; Silva, F S; Miranda, G

    2017-05-01

    Additive manufacturing (AM) technologies enable the fabrication of innovative structures with complex geometries not easily manufactured by traditional processes. Regarding metallic cellular structures with tailored/customized mechanical and wear performance aiming to biomedical applications, Selective Laser Melting (SLM) is a remarkable solution for their production. Focusing on prosthesis and implants, in addition to a suitable Young's modulus it is important to assess the friction response and wear resistance of these cellular structures in a natural environment. In this sense, five cellular Ti6Al4V structures with different open-cell sizes (100-500µm) were designed and produced by SLM. These structures were tribologicaly tested against alumina using a reciprocating sliding ball-on-plate tribometer. Samples were submerged in Phosphate Buffered Saline (PBS) fluid at 37°C, in order to mimic in some extent the human body environment. The results showed that friction and wear performance of Ti6Al4V cellular structures is influenced by the structure open-cell size. The higher wear resistance was obtained for structures with 100µm designed open-cell size due to the higher apparent area of contact to support tribological loading. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Innovative economic structuressupport for development of urban systems

    Directory of Open Access Journals (Sweden)

    Florin Marian Buhociu

    2013-12-01

    Full Text Available Training and development of urban systems (US is a main direction of territorial and regional development which requires multiple studies, including those of economic background. They should aim to highlight, on the one hand, the economic potential of geographical areas making up the urban system and secondly to assess development trends you need to focus their own resources and those that are to be attracted to getting a economic trend upward in that area. It is therefore very important a zonal configuration of the urban system by following the joint capitalization of existing human and material resources, including by building synergy effect to be achieved following the joint evolution of settlements in the US. Along with the development of US is required, from the economical point of view, to implement new forms of economic structures to directly potentate the development of the area through constant cooperation, innovation and transfer of know-how. Romania currently has seven major urban centers that were selected and were assigned the role of growth poles. There were also 13 designated urban growth poles, including Galati and Braila. Urban agglomeration formed by the two municipalities, located at a distance from each other of about 25 km, is the second largest in the country after Bucharest. There is currently underway specialized documentation to achieve an optimal configuration for US Galati-Braila. From the economic point of view in the respective area can be implemented new development structures of cluster (Porter, M.E.,2000 type aimed at achieving the competitiveness poles and which will constitute the true engine of economic development. These two new structures of economic development are characterized by the fact that they allow and provide the necessary conditions to attract the systems and modern technologies to build local innovation systems that can be integrated into similar systems at regional and even national level. It is

  2. Designing a Decision Support System (DSS for Supplier Selection in Multiple Discount Environment

    Directory of Open Access Journals (Sweden)

    Marzieh Shahrezaee

    2012-09-01

    Full Text Available This research aims at developing original components of Decision Support System (DSS in order to support the evaluation and selection of suppliers in multi products having limited capacity. To achieve this purpose, researchers have proposed three different models based on which suppliers allow selecting their own desired type of discount. Firstly based on the performed studies, some criteria have been suggested for evaluating the suppliers’ capability. These criteria will be selected by the buyer with respect to the purchase condition and type of the industry, and their importance level will be determined. Then based on multi-criteria decision models, evaluation of all the suppliers will be done. In this study fuzzy numbers are applied so as to translate qualitative criteria into quantitative one. Suppliers have been ranked according to the scores they have gained and the selection share of each from the whole quantity has been determined based on the multi-objective mathematical model. The existing model has exerted practical ways such as taking loans with determined interest as well as certain variables in order to compensate the shortage of budget the buyer encounters with. Outputs, which are, the selective suppliers and orders assigned to each of them are also to be considered by using Genetic Algorithm in MATLAB software for three parts in Emersan Company accordingly.

  3. Selecting Products Considering the Regret Behavior of Consumer: A Decision Support Model Based on Online Ratings

    Directory of Open Access Journals (Sweden)

    Xia Liang

    2018-05-01

    Full Text Available With the remarkable promotion of e-commerce platforms, consumers increasingly prefer to purchase products online. Online ratings facilitate consumers to choose among products. Thus, to help consumers effectively select products, it is necessary to provide decision support methods for consumers to trade online. Considering the decision makers are bounded rational, this paper proposes a novel decision support model for product selection based on online ratings, in which the regret aversion behavior of consumers is formulated. Massive online ratings provided by experienced consumers for alternative products associated with several evaluation attributes are obtained by software finders. Then, the evaluations of alternative products in format of stochastic variables are conducted. To select a desirable alternative product, a novel method is introduced to calculate gain and loss degrees of each alternative over others. Considering the regret behavior of consumers in the product selection process, the regret and rejoice values of alternative products for consumer are computed to obtain the perceived utility values of alternative products. According to the prior order of the evaluation attributes provided by the consumer, the prior weights of attributes are determined based on the perceived utility values of alternative products. Furthermore, the overall perceived utility values of alternative products are obtained to generate a ranking result. Finally, a practical example from Zol.com.cn for tablet computer selection is used to demonstrate the feasibility and practically of the proposed model.

  4. Generalized structural equations improve sexual-selection analyses.

    Directory of Open Access Journals (Sweden)

    Sonia Lombardi

    Full Text Available Sexual selection is an intense evolutionary force, which operates through competition for the access to breeding resources. There are many cases where male copulatory success is highly asymmetric, and few males are able to sire most females. Two main hypotheses were proposed to explain this asymmetry: "female choice" and "male dominance". The literature reports contrasting results. This variability may reflect actual differences among studied populations, but it may also be generated by methodological differences and statistical shortcomings in data analysis. A review of the statistical methods used so far in lek studies, shows a prevalence of Linear Models (LM and Generalized Linear Models (GLM which may be affected by problems in inferring cause-effect relationships; multi-collinearity among explanatory variables and erroneous handling of non-normal and non-continuous distributions of the response variable. In lek breeding, selective pressure is maximal, because large numbers of males and females congregate in small arenas. We used a dataset on lekking fallow deer (Dama dama, to contrast the methods and procedures employed so far, and we propose a novel approach based on Generalized Structural Equations Models (GSEMs. GSEMs combine the power and flexibility of both SEM and GLM in a unified modeling framework. We showed that LMs fail to identify several important predictors of male copulatory success and yields very imprecise parameter estimates. Minor variations in data transformation yield wide changes in results and the method appears unreliable. GLMs improved the analysis, but GSEMs provided better results, because the use of latent variables decreases the impact of measurement errors. Using GSEMs, we were able to test contrasting hypotheses and calculate both direct and indirect effects, and we reached a high precision of the estimates, which implies a high predictive ability. In synthesis, we recommend the use of GSEMs in studies on

  5. Printability Study of Bioprinted Tubular Structures Using Liquid Hydrogel Precursors in a Support Bath

    Directory of Open Access Journals (Sweden)

    Houzhu Ding

    2018-03-01

    Full Text Available Microextrusion-based bioprinting within a support bath material is an emerging additive manufacturing paradigm for complex three-dimensional (3D tissue construct fabrication. Although a support bath medium enables arbitrary in-process geometries to be printed, a significant challenge lies in preserving the shape fidelity upon the extraction of the support bath material. Based on the bioprinting in a support bath paradigm, this paper advances quantitative analyses to systematically determine the printability of cell-laden liquid hydrogel precursors towards filament-based tissue constructs. First, a yield stress nanoclay material is judiciously selected as the support bath medium owing to its insensitivity to temperature and ionic variations that are considered in the context of the current gelatin-alginate bio-ink material formulation. Furthermore, phenomenological observations for the rheology-mediated print outcomes enable the compositions for the bio-ink material (10% gelatin, 3% alginate, in tandem with the support bath medium (4% nanoclay, 0.5% CaCl2, to be identified. To systematically evaluate the performance outcomes for bioprinting within a support bath, this paper advances an experimental parametric study to optimize the 3D structural shape fidelity by varying parameters such as the layer height, extrusion flowrate, printing temperature, and printhead speed, towards fabricating complex 3D structures with the stabilization of the desired shape outcome. Specifically, it is found that the layer height and printhead speed are determinant parameters for the extent of successive layer fusion. Moreover, maintenance of an optimal bath temperature is identified as a key parameter for establishing the printability for the hydrogel bio-ink. Studying this effect is enabled by the custom design of a PID temperature control system with integration with the bioprinter for real-time precision control of the support bath temperature. In order to qualify

  6. New approach to the design of core support structures for large LMFBR plants

    International Nuclear Information System (INIS)

    Burelbach, J.P.; Kann, W.J.; Pan, Y.C.; Saiveau, J.G.; Seidensticker, R.W.

    1984-01-01

    The paper describes an innovative design concept for a LMFBR Core Support Structure. A hanging Core Support Structure is described and analyzed. The design offers inherent safety features, constructibility advantages, and potential cost reductions

  7. THE PROJECT OF THE EXPERT SYSTEM TO SUPPORTING OF SELECTION OF PARTS AND ASSEMBLIES OF MACHINES

    Directory of Open Access Journals (Sweden)

    Sebastian RZYDZIK

    2014-06-01

    Full Text Available This paper the design of the expert system that supports mechanical engineer in the process of selecting the parts and assemblies was presented. In the description of the proposed expert system, was made reference to the general form of such systems, that consist of such components as: user interface, inference engine, knowledge base and database. It also, scenario that describes the steps of the use of the proposed expert system was presented. Finally, an example of the use the expert system during the selection of the components of the drive system was shown.

  8. Clinical Decision Support Tools for Selecting Interventions for Patients with Disabling Musculoskeletal Disorders

    DEFF Research Database (Denmark)

    Gross, Douglas P; Armijo-Olivo, Susan; Shaw, William S

    2016-01-01

    Purpose We aimed to identify and inventory clinical decision support (CDS) tools for helping front-line staff select interventions for patients with musculoskeletal (MSK) disorders. Methods We used Arksey and O'Malley's scoping review framework which progresses through five stages: (1) identifying...... the research question; (2) identifying relevant studies; (3) selecting studies for analysis; (4) charting the data; and (5) collating, summarizing and reporting results. We considered computer-based, and other available tools, such as algorithms, care pathways, rules and models. Since this research crosses...

  9. Rubber bearing and bitumen infill support system for seismic protection of nuclear power plant structures

    International Nuclear Information System (INIS)

    Ahmed, K.M.

    1981-01-01

    The prestressed concrete pressure vessel (PCPV) for the AGR is of cylindrical type. The whole of the reactor primary circuit is contained within the PCPV vault and includes the reactor core and support structures, boilers and gas circulators. The PCPV is essentially free standing on its foundation raft. In order to transmit gravitational and seismic loads between the PCPV and the foundation raft, a support system is used which consists of concentric rings of neoprene pads and a thin annulus of bitumen infill. In order to assess the importance of both stiffness and damping of the PCPV support system on the overall AGR response, detailed parametric studies were carried out using time-history dynamic analysis in conjunction with the modal superposition technique. The effects of both stiffness and damping are compared in terms of the maximum dynamic response (maximum accelerations and maximum relative displacements) and also floor response spectra at various locations on the nuclear island. It is clearly apparent from these investigations that for an appropriate range of structures on the nuclear island (such as the PCPV and its internals), greater reduction in seismic loading can be achieved by proper selection of stiffnesses and damping of the PCPV support system without resorting to strengthening techniques. (orig./HP)

  10. Fabrication variables affecting the structure and properties of supported carbon molecular sieve membranes for hydrogen separation

    KAUST Repository

    Briceñ o, Kelly; Montané , Daniel; Garcia-Valls, Ricard; Iulianelli, Adolfo; Basile, Angelo

    2012-01-01

    A high molecular weight polyimide (Matrimid) was used as a precursor for fabricating supported carbon molecular sieve membranes without crack formation at 550-700°C pyrolysis temperature. A one-step polymer (polyimide) coating method as precursor of carbon layer was used without needing a prior modification of a TiO 2 macroporous support. The following fabrication variables were optimized and studied to determine their effect on the carbon structure: polymeric solution concentration, solvent extraction, heating rate and pyrolysis temperature. Two techniques (Thermogravimetric analysis and Raman spectroscopy) were used to determine these effects on final carbon structure. Likewise, the effect of the support was also reported as an additional and important variable in the design of supported carbon membranes. Atomic force microscopy and differential scanning calorimetry quantified the degree of influence. Pure gas permeation tests were performed using CH 4, CO, CO 2 and H 2. The presence of a molecular sieving mechanism was confirmed after defects were plugged with PDMS solution at 12wt%. Gas selectivities higher than Knudsen theoretical values were reached with membranes obtained over 650°C, showing as best values 4.46, 4.70 and 10.62 for H 2/N 2, H 2/CO and H 2/CH 4 ratio, respectively. Permeance values were over 9.82×10 -9mol/(m 2Pas)during pure hydrogen permeation tests. © 2012 Elsevier B.V.

  11. Fabrication variables affecting the structure and properties of supported carbon molecular sieve membranes for hydrogen separation

    KAUST Repository

    Briceño, Kelly

    2012-10-01

    A high molecular weight polyimide (Matrimid) was used as a precursor for fabricating supported carbon molecular sieve membranes without crack formation at 550-700°C pyrolysis temperature. A one-step polymer (polyimide) coating method as precursor of carbon layer was used without needing a prior modification of a TiO 2 macroporous support. The following fabrication variables were optimized and studied to determine their effect on the carbon structure: polymeric solution concentration, solvent extraction, heating rate and pyrolysis temperature. Two techniques (Thermogravimetric analysis and Raman spectroscopy) were used to determine these effects on final carbon structure. Likewise, the effect of the support was also reported as an additional and important variable in the design of supported carbon membranes. Atomic force microscopy and differential scanning calorimetry quantified the degree of influence. Pure gas permeation tests were performed using CH 4, CO, CO 2 and H 2. The presence of a molecular sieving mechanism was confirmed after defects were plugged with PDMS solution at 12wt%. Gas selectivities higher than Knudsen theoretical values were reached with membranes obtained over 650°C, showing as best values 4.46, 4.70 and 10.62 for H 2/N 2, H 2/CO and H 2/CH 4 ratio, respectively. Permeance values were over 9.82×10 -9mol/(m 2Pas)during pure hydrogen permeation tests. © 2012 Elsevier B.V.

  12. Electronic structure and physicochemical properties of selected penicillins

    Science.gov (United States)

    Soriano-Correa, Catalina; Ruiz, Juan F. Sánchez; Raya, A.; Esquivel, Rodolfo O.

    Traditionally, penicillins have been used as antibacterial agents due to their characteristics and widespread applications with few collateral effects, which have motivated several theoretical and experimental studies. Despite the latter, their mechanism of biological action has not been completely elucidated. We present a theoretical study at the Hartree-Fock and density functional theory (DFT) levels of theory of a selected group of penicillins such as the penicillin-G, amoxicillin, ampicillin, dicloxacillin, and carbenicillin molecules, to systematically determine the electron structure of full ?-lactam antibiotics. Our results allow us to analyze the electronic properties of the pharmacophore group, the aminoacyl side-chain, and the influence of the substituents (R and X) attached to the aminoacyl side-chain at 6? (in contrast with previous studies focused at the 3? substituents), and to corroborate the results of previous studies performed at the semiempirical level, solely on the ?-lactam ring of penicillins. Besides, several density descriptors are determined with the purpose of analyzing their link to the antibacterial activity of these penicillin compounds. Our results for the atomic charges (fitted to the electrostatic potential), the bond orders, and several global reactivity descriptors, such as the dipole moments, ionization potential, hardness, and the electrophilicity index, led us to characterize: the active sites, the effect of the electron-attracting substituent properties and their physicochemical features, which altogether, might be important to understand the biological activity of these type of molecules.

  13. Degeneracy-driven self-structuring dynamics in selective repertoires.

    Science.gov (United States)

    Atamas, Sergei P; Bell, Jonathan

    2009-08-01

    Numerous biological interactions, such as interactions between T cell receptors or antibodies with antigens, interactions between enzymes and substrates, or interactions between predators and prey are often not strictly specific. In such less specific, or "sloppy," systems, referred to here as degenerate systems, a given unit of a diverse resource (antigens, enzymatic substrates, prey) is at risk of being recognized and consumed by multiple consumers (lymphocytes, enzymes, predators). In this study, we model generalized degenerate consumer-resource systems of Lotka-Volterra and Verhulst types. In the degenerate systems of Lotka-Volterra, there is a continuum of types of consumer and resource based on variation of a single trait (characteristic, or preference). The consumers experience competition for a continuum of resource types. This non-local interaction system is modeled with partial differential-integral equations and shows spontaneous self-structuring of the consumer population that depends on the degree of interaction degeneracy between resource and consumer, but does not mirror the distribution of resource. We also show that the classical Verhulst (i.e. logistic) single population model can be generalized to a degenerate model, which shows qualitative behavior similar to that in the degenerate Lotka-Volterra model. These results provide better insight into the dynamics of selective systems in biology, suggesting that adaptation of degenerate repertoires is not a simple "mirroring" of the environment by the "fittest" elements of population.

  14. Support structures for optical components in the Laser Demonstration Facility

    International Nuclear Information System (INIS)

    Finucane, R.G.

    1985-01-01

    The laser system in the Laser Demonstration Facility is mounted on an array of 108 support columns. This milestone report describes the design, analyses, testing, fabrication, installation, and performance characteristics of these supports

  15. Highly selective oxidative dehydrogenation of ethane with supported molten chloride catalysts

    Energy Technology Data Exchange (ETDEWEB)

    Gaertner, C.A.; Veen, A.C. van; Lercher, J.A. [Technische Univ. Muenchen (Germany). Catalysis Research Center

    2011-07-01

    Ethene production is one of the most important transformations in chemical industry, given that C{sub 2}H{sub 4} serves as building block for many mass-market products. Besides conventional thermal processes like steam cracking of ethane, ethane can be produced selectively by catalytic processes. One of the classes of catalysts that have been reported in literature as active and highly selective for the oxidative dehydrogenation of ethane is that of supported molten chloride catalysts, containing an alkali chloride overlayer on a solid support. This work deals with fundamental aspects of the catalytic action in latter class of catalysts. Results from kinetic reaction studies are related to observations in detailed characterization and lead to a comprehensive mechanistic understanding. Of fundamental importance towards mechanistic insights is the oxygen storage capacity of the catalysts that has been determined by transient step experiments. (orig.)

  16. A decision support tool for sustainable supplier selection in manufacturing firms

    Directory of Open Access Journals (Sweden)

    Ifeyinwa Orji

    2014-10-01

    Full Text Available Purpose: Most original equipment manufacturers (OEMs are strategically involved in supplier base rationalization and increased consciousness of sustainable development thus, reinforcing need for accurately considering sustainability in supplier selection to improve organizational performance. In real industrial case, imprecise data, ambiguity of human judgment, uncertainty among sustainability factors and the need to capture all subjective and objective criteria are unavoidable and pose huge challenge to accurately incorporate sustainability factors into supplier selection.Methodology: This study develops a model based on integrated multi- criteria decision making (MCDM methods to solve such problems. The developed model applies Fuzzy logic, DEMATEL and TOPSIS to effectively analyze the interdependencies between sustainability criteria and to select the best sustainable supplier in fuzzy environment while capturing all subjective and objective criteria. A case study is illustrated to test the proposed model in a gear manufacturing company, an OEM to provide insights and for practical applications.Findings: Results show that social factors of sustainability ranks as the most important in supplier selection. However, the most influential sustainability sub- criteria are work safety (WS and quality.Originality/Value: The model is capable of capturing all subjective and objective criteria in fuzzy environment to accurately incorporate sustainability factors in supplier selection. It is decision support tool relevant for providing insights to managers while implementing sustainable supplier selection.

  17. Single Pot Selective Hydrogenation of Furfural to 2-Methylfuran Over Carbon Supported Iridium Catalysts

    KAUST Repository

    Date, Nandan S; Hengne, Amol Mahalingappa; Huang, Kuo-Wei; Chikate, Rajeev C.; Rode, C. V.

    2018-01-01

    Various iridium supported carbon catalysts were prepared and screened for direct hydrogenation of furfural (FFR) to 2-methyl furan (2-MF). Amongest these, 5% Ir/C showed excellent results with complete FFR conversion and highest selectivity of 95% to 2-MF at very low H2 pressure of 100 psig. Metallic (Iro) and oxide ( IrO2) phases of Ir catalyzed first step hydrogenation involving FFR to FAL and subsequent hydrogenation to 2-MF,respecively. This was confirmed by XPS analysis and some controlled experiments. At low temperature of 140 oC, almost equal selectivities of FAL (42%) and 2-MF (43%) were observed, while higher temperature (220oC) favored selective hydrodeoxygenation. At optimized temperature, 2-MF formed selectively while higher pressure and higher catalyst loading favored ring hydrogenation of furfural rather than side chain hydrogenation. With combination of several control experimental results and detailed catalyst characterization, a plausible reaction pathway has been proposed for selective formation of 2-MF. The selectivity to various other products in FFR hydrogenation can be manipulated by tailoring the reaction conditions over the same catalyst.

  18. Single Pot Selective Hydrogenation of Furfural to 2-Methylfuran Over Carbon Supported Iridium Catalysts

    KAUST Repository

    Date, Nandan S

    2018-03-20

    Various iridium supported carbon catalysts were prepared and screened for direct hydrogenation of furfural (FFR) to 2-methyl furan (2-MF). Amongest these, 5% Ir/C showed excellent results with complete FFR conversion and highest selectivity of 95% to 2-MF at very low H2 pressure of 100 psig. Metallic (Iro) and oxide ( IrO2) phases of Ir catalyzed first step hydrogenation involving FFR to FAL and subsequent hydrogenation to 2-MF,respecively. This was confirmed by XPS analysis and some controlled experiments. At low temperature of 140 oC, almost equal selectivities of FAL (42%) and 2-MF (43%) were observed, while higher temperature (220oC) favored selective hydrodeoxygenation. At optimized temperature, 2-MF formed selectively while higher pressure and higher catalyst loading favored ring hydrogenation of furfural rather than side chain hydrogenation. With combination of several control experimental results and detailed catalyst characterization, a plausible reaction pathway has been proposed for selective formation of 2-MF. The selectivity to various other products in FFR hydrogenation can be manipulated by tailoring the reaction conditions over the same catalyst.

  19. Nutritional and cultural aspects of plant species selection for a controlled ecological life support system

    Science.gov (United States)

    Hoff, J. E.; Howe, J. M.; Mitchell, C. A.

    1982-01-01

    The feasibility of using higher plants in a controlled ecological life support system is discussed. Aspects of this system considered important in the use of higher plants include: limited energy, space, and mass, and problems relating to cultivation and management of plants, food processing, the psychological impact of vegetarian diets, and plant propagation. A total of 115 higher plant species are compared based on 21 selection criteria.

  20. A life cycle framework to support materials selection for Ecodesign: A case study on biodegradable polymers

    International Nuclear Information System (INIS)

    Ribeiro, I.; Peças, P.; Henriques, E.

    2013-01-01

    Highlights: • Life cycle framework to support material selection in Ecodesign. • Early design stage estimates and sensitivity analyses based on process-based models. • Sensitivity analysis to product geometry, industrial context and EoL scenarios. • Cost and environmental performance comparison – BDP vs. fossil based polymers. • Best alternatives mapping integrating cost and environmental performances. - Abstract: Nowadays society compels designers to develop more sustainable products. Ecodesign directs product design towards the goal of reducing environmental impacts. Within Ecodesign, materials selection plays a major role on product cost and environmental performance throughout its life cycle. This paper proposes a comprehensive life cycle framework to support Ecodesign in material selection. Dealing with new materials and technologies in early design stages, process-based models are used to represent the whole life cycle and supply integrated data to assess material alternatives, considering cost and environmental dimensions. An integrated analysis is then proposed to support decision making by mapping the best alternative materials according to the importance given to upstream and downstream life phases and to the environmental impacts. The proposed framework is applied to compare the life cycle performance of injection moulded samples made of four commercial biodegradable polymers with different contents of Thermo Plasticized Starch and PolyLactic Acid and a common fossil based polymer, Polypropylene. Instead of labelling materials just as “green”, the need to fully capture all impacts in the whole life cycle was shown. The fossil based polymer is the best economic alternative, but polymers with higher content of Thermo Plasticized Starch have a better environmental performance. However, parts geometry and EoL scenarios play a major role on the life cycle performance of candidate materials. The selection decision is then supported by mapping

  1. Clonality, genetic diversity and support for the diversifying selection hypothesis in natural populations of a flower-living yeast.

    Science.gov (United States)

    Herrera, C M; Pozo, M I; Bazaga, P

    2011-11-01

    Vast amounts of effort have been devoted to investigate patterns of genetic diversity and structuring in plants and animals, but similar information is scarce for organisms of other kingdoms. The study of the genetic structure of natural populations of wild yeasts can provide insights into the ecological and genetic correlates of clonality, and into the generality of recent hypotheses postulating that microbial populations lack the potential for genetic divergence and allopatric speciation. Ninety-one isolates of the flower-living yeast Metschnikowia gruessii from southeastern Spain were DNA fingerprinted using amplified fragment length polymorphism (AFLP) markers. Genetic diversity and structuring was investigated with band-based methods and model- and nonmodel-based clustering. Linkage disequilibrium tests were used to assess reproduction mode. Microsite-dependent, diversifying selection was tested by comparing genetic characteristics of isolates from bumble bee vectors and different floral microsites. AFLP polymorphism (91%) and genotypic diversity were very high. Genetic diversity was spatially structured, as shown by amova (Φ(st)  = 0.155) and clustering. The null hypothesis of random mating was rejected, clonality seeming the prevailing reproductive mode in the populations studied. Genetic diversity of isolates declined from bumble bee mouthparts to floral microsites, and frequency of five AFLP markers varied significantly across floral microsites, thus supporting the hypothesis of diversifying selection on clonal lineages. Wild populations of clonal fungal microbes can exhibit levels of genetic diversity and spatial structuring that are not singularly different from those shown by sexually reproducing plants or animals. Microsite-dependent, divergent selection can maintain high local and regional genetic diversity in microbial populations despite extensive clonality. © 2011 Blackwell Publishing Ltd.

  2. Two different mechanisms support selective attention at different phases of training.

    Science.gov (United States)

    Itthipuripat, Sirawaj; Cha, Kexin; Byers, Anna; Serences, John T

    2017-06-01

    Selective attention supports the prioritized processing of relevant sensory information to facilitate goal-directed behavior. Studies in human subjects demonstrate that attentional gain of cortical responses can sufficiently account for attention-related improvements in behavior. On the other hand, studies using highly trained nonhuman primates suggest that reductions in neural noise can better explain attentional facilitation of behavior. Given the importance of selective information processing in nearly all domains of cognition, we sought to reconcile these competing accounts by testing the hypothesis that extensive behavioral training alters the neural mechanisms that support selective attention. We tested this hypothesis using electroencephalography (EEG) to measure stimulus-evoked visual responses from human subjects while they performed a selective spatial attention task over the course of ~1 month. Early in training, spatial attention led to an increase in the gain of stimulus-evoked visual responses. Gain was apparent within ~100 ms of stimulus onset, and a quantitative model based on signal detection theory (SDT) successfully linked the magnitude of this gain modulation to attention-related improvements in behavior. However, after extensive training, this early attentional gain was eliminated even though there were still substantial attention-related improvements in behavior. Accordingly, the SDT-based model required noise reduction to account for the link between the stimulus-evoked visual responses and attentional modulations of behavior. These findings suggest that training can lead to fundamental changes in the way attention alters the early cortical responses that support selective information processing. Moreover, these data facilitate the translation of results across different species and across experimental procedures that employ different behavioral training regimes.

  3. Two different mechanisms support selective attention at different phases of training

    Science.gov (United States)

    Cha, Kexin; Byers, Anna; Serences, John T.

    2017-01-01

    Selective attention supports the prioritized processing of relevant sensory information to facilitate goal-directed behavior. Studies in human subjects demonstrate that attentional gain of cortical responses can sufficiently account for attention-related improvements in behavior. On the other hand, studies using highly trained nonhuman primates suggest that reductions in neural noise can better explain attentional facilitation of behavior. Given the importance of selective information processing in nearly all domains of cognition, we sought to reconcile these competing accounts by testing the hypothesis that extensive behavioral training alters the neural mechanisms that support selective attention. We tested this hypothesis using electroencephalography (EEG) to measure stimulus-evoked visual responses from human subjects while they performed a selective spatial attention task over the course of ~1 month. Early in training, spatial attention led to an increase in the gain of stimulus-evoked visual responses. Gain was apparent within ~100 ms of stimulus onset, and a quantitative model based on signal detection theory (SDT) successfully linked the magnitude of this gain modulation to attention-related improvements in behavior. However, after extensive training, this early attentional gain was eliminated even though there were still substantial attention-related improvements in behavior. Accordingly, the SDT-based model required noise reduction to account for the link between the stimulus-evoked visual responses and attentional modulations of behavior. These findings suggest that training can lead to fundamental changes in the way attention alters the early cortical responses that support selective information processing. Moreover, these data facilitate the translation of results across different species and across experimental procedures that employ different behavioral training regimes. PMID:28654635

  4. Final report WP 4.2 : Support Structure Concepts for Deep Water Sites: Deliverable D4.2.8 (WP4: offshore foundations and support structures)

    NARCIS (Netherlands)

    De Vries, W.E.; Vemula, N.K.; Passon, P.; Fischer, T.; Kaufer, D.; Matha, D.; Schmidt, B.; Vorpahl, F.

    2011-01-01

    With the number of offshore wind farms rapidly increasing, in a wide variety of site conditions and using different turbine sizes, the need for alternative support structures other than the conventional monopile structure is apparent and several projects have been realised using other support

  5. Decision Support for Personalized Cloud Service Selection through Multi-Attribute Trustworthiness Evaluation

    Science.gov (United States)

    Ding, Shuai; Xia, Chen-Yi; Zhou, Kai-Le; Yang, Shan-Lin; Shang, Jennifer S.

    2014-01-01

    Facing a customer market with rising demands for cloud service dependability and security, trustworthiness evaluation techniques are becoming essential to cloud service selection. But these methods are out of the reach to most customers as they require considerable expertise. Additionally, since the cloud service evaluation is often a costly and time-consuming process, it is not practical to measure trustworthy attributes of all candidates for each customer. Many existing models cannot easily deal with cloud services which have very few historical records. In this paper, we propose a novel service selection approach in which the missing value prediction and the multi-attribute trustworthiness evaluation are commonly taken into account. By simply collecting limited historical records, the current approach is able to support the personalized trustworthy service selection. The experimental results also show that our approach performs much better than other competing ones with respect to the customer preference and expectation in trustworthiness assessment. PMID:24972237

  6. DECISION SUPPORT CONCEPT TO MANAGEMENT OF CONSTRUCTION PROJECTS - PROBLEM OF CONSTRUCTION SITE SELECTION

    Directory of Open Access Journals (Sweden)

    Nikša Jajac

    2013-02-01

    Full Text Available The aim of this paper is to present Decision Support Concept (DSC for management of construction projects. Focus of our research is in application of multicritera methods (MCM to decision making in planning phase of construction projects (related to the problem of construction sites selection. The problem is identified as a significant one from many different aspects such as economic aspect, civil engineering aspect, etc. what indicates the necessity for evaluation of multiple sites by several different criteria. Therefore, DSC for construction site selection based on PROMETHEE method is designed. In order to define the appropriate criteria, their weights and preference functions for the concept, three groups of stakeholders are involved (investors, construction experts and experts for real estate market in its design. AHP method has been used for determination of criteria weights. The model has been tested on the problem of site selection for construction of residential-commercial building in four largest cities in Croatia.

  7. Structural Bioinformatics-Based Prediction of Exceptional Selectivity of p38 MAP Kinase Inhibitor PH-797804

    Energy Technology Data Exchange (ETDEWEB)

    Xing, Li; Shieh, Huey S.; Selness, Shaun R.; Devraj, Rajesh V.; Walker, John K.; Devadas, Balekudru; Hope, Heidi R.; Compton, Robert P.; Schindler, John F.; Hirsch, Jeffrey L.; Benson, Alan G.; Kurumbail, Ravi G.; Stegeman, Roderick A.; Williams, Jennifer M.; Broadus, Richard M.; Walden, Zara; Monahan, Joseph B.; Pfizer

    2009-07-24

    PH-797804 is a diarylpyridinone inhibitor of p38{alpha} mitogen-activated protein (MAP) kinase derived from a racemic mixture as the more potent atropisomer (aS), first proposed by molecular modeling and subsequently confirmed by experiments. On the basis of structural comparison with a different biaryl pyrazole template and supported by dozens of high-resolution crystal structures of p38{alpha} inhibitor complexes, PH-797804 is predicted to possess a high level of specificity across the broad human kinase genome. We used a structural bioinformatics approach to identify two selectivity elements encoded by the TXXXG sequence motif on the p38{alpha} kinase hinge: (i) Thr106 that serves as the gatekeeper to the buried hydrophobic pocket occupied by 2,4-difluorophenyl of PH-797804 and (ii) the bidentate hydrogen bonds formed by the pyridinone moiety with the kinase hinge requiring an induced 180{sup o} rotation of the Met109-Gly110 peptide bond. The peptide flip occurs in p38{alpha} kinase due to the critical glycine residue marked by its conformational flexibility. Kinome-wide sequence mining revealed rare presentation of the selectivity motif. Corroboratively, PH-797804 exhibited exceptionally high specificity against MAP kinases and the related kinases. No cross-reactivity was observed in large panels of kinase screens (selectivity ratio of >500-fold). In cellular assays, PH-797804 demonstrated superior potency and selectivity consistent with the biochemical measurements. PH-797804 has met safety criteria in human phase I studies and is under clinical development for several inflammatory conditions. Understanding the rationale for selectivity at the molecular level helps elucidate the biological function and design of specific p38{alpha} kinase inhibitors.

  8. Case study: highly loaded MSE bridge supporting structure, Syncrude NMAPS conveyor overpasses

    Energy Technology Data Exchange (ETDEWEB)

    Scherger, B.; Brockbank, B. [Reinforced Earth Company Ltd., Edmonton, AB (Canada); Mimura, W. [Syncrude Canada Ltd., Edmonton, AB (Canada)

    2005-07-01

    A crusher and conveyor system was constructed at the Mildred Lake Oil Sands Mine near Fort McMurray, Alberta in order to facilitate ore delivery from Syncrude's North Mine. As part of this North Mine Auxiliary Production System (NMAPS), Syncrude Canada and their consultant Cosyn Technology identified the need for 3 overpasses over conveyors in the North Mine in order to provide unrestricted crossing over the operating conveyor system for the heavy hauler trucks and light vehicle mine traffic. The overpasses were designed to support the dead load of the granular fill and the live load of two loaded heavy hauler trucks, with a design load for each loaded hauler of 670 900 kg. This paper reviewed various aspects of the design from planning, structure selection, and overall stability and bearing capacity considerations. The different designs in the 3 new overpasses accommodated foundation and loading requirements. The designs ranged from the use of precast one-piece reinforced concrete arches, Mechanically Stabilized Earth (MSE) bridge abutment technology, and a combination of the two. The MSE retaining walls directly supported the bridge superstructure without the use of piles or other deep structural foundations. The design was challenging because of the significant vertical stresses transferred onto the wall. All 3 overpasses also used MSE walls for the supporting end wing walls. The main focus of this paper was on the heavily loaded MSE walls supporting the bridge abutment style overpasses. This structure has illustrated the capability of properly designed MSE wall structures with steel soil reinforcement and reinforced precast concrete face panels to successfully carry bridge footing pressure loadings up to 545 kPa. It was concluded that this case has good potential for use in future bridge projects in both the industrial and highway sectors. 2 refs., 7 figs.

  9. Genetic structure and signatures of selection in grey reef sharks (Carcharhinus amblyrhynchos).

    Science.gov (United States)

    Momigliano, P; Harcourt, R; Robbins, W D; Jaiteh, V; Mahardika, G N; Sembiring, A; Stow, A

    2017-09-01

    With overfishing reducing the abundance of marine predators in multiple marine ecosystems, knowledge of genetic structure and local adaptation may provide valuable information to assist sustainable management. Despite recent technological advances, most studies on sharks have used small sets of neutral markers to describe their genetic structure. We used 5517 nuclear single-nucleotide polymorphisms (SNPs) and a mitochondrial DNA (mtDNA) gene to characterize patterns of genetic structure and detect signatures of selection in grey reef sharks (Carcharhinus amblyrhynchos). Using samples from Australia, Indonesia and oceanic reefs in the Indian Ocean, we established that large oceanic distances represent barriers to gene flow, whereas genetic differentiation on continental shelves follows an isolation by distance model. In Australia and Indonesia differentiation at nuclear SNPs was weak, with coral reefs acting as stepping stones maintaining connectivity across large distances. Differentiation of mtDNA was stronger, and more pronounced in females, suggesting sex-biased dispersal. Four independent tests identified a set of loci putatively under selection, indicating that grey reef sharks in eastern Australia are likely under different selective pressures to those in western Australia and Indonesia. Genetic distances averaged across all loci were uncorrelated with genetic distances calculated from outlier loci, supporting the conclusion that different processes underpin genetic divergence in these two data sets. This pattern of heterogeneous genomic differentiation, suggestive of local adaptation, has implications for the conservation of grey reef sharks; furthermore, it highlights that marine species showing little genetic differentiation at neutral loci may exhibit patterns of cryptic genetic structure driven by local selection.

  10. Prediction of Protein Structural Class Based on Gapped-Dipeptides and a Recursive Feature Selection Approach

    Directory of Open Access Journals (Sweden)

    Taigang Liu

    2015-12-01

    Full Text Available The prior knowledge of protein structural class may offer useful clues on understanding its functionality as well as its tertiary structure. Though various significant efforts have been made to find a fast and effective computational approach to address this problem, it is still a challenging topic in the field of bioinformatics. The position-specific score matrix (PSSM profile has been shown to provide a useful source of information for improving the prediction performance of protein structural class. However, this information has not been adequately explored. To this end, in this study, we present a feature extraction technique which is based on gapped-dipeptides composition computed directly from PSSM. Then, a careful feature selection technique is performed based on support vector machine-recursive feature elimination (SVM-RFE. These optimal features are selected to construct a final predictor. The results of jackknife tests on four working datasets show that our method obtains satisfactory prediction accuracies by extracting features solely based on PSSM and could serve as a very promising tool to predict protein structural class.

  11. Health of women: associations among life events, social support, and personality for selected patient groups.

    Science.gov (United States)

    Norlander, T; Dahlin, A; Archer, T

    2000-02-01

    This study examined the effects of life events, social support, personality traits, and siblings' birth-order on the health of women. 199 middle-class participants were included. 95 women, randomly assigned from four different patient groups, were compared with a control group of 96 randomly selected women without any special health problems. They completed a questionnaire which included questions regarding family background, health, different life events, social support, and signs of disease and a projective test, the Sivik Psychosomatism Test. Analysis indicated that report of negative life events was associated with more physical symptoms than positive life events and that the patient groups reported more negative life events and less social support than the control group.

  12. Average and local structure of selected metal deuterides

    Energy Technology Data Exchange (ETDEWEB)

    Soerby, Magnus H.

    2005-07-01

    The main topic of this thesis is improved understanding of site preference and mutual interactions of deuterium (D) atoms in selected metallic metal deuterides. The work was partly motivated by reports of abnormally short D-D distances in RENiInD1.33 compounds (RE = rear-earth element; D-D {upsilon} square root 1.6 Aa) which show that the so-called Switendick criterion that demands a D-D separation of at least 2 Aa, is not a universal rule. The work is experimental and heavily based on scattering measurements using x-rays (lab and synchrotron) and neutrons. In order to enhance data quality, deuterium is almost exclusively used instead of natural hydrogen in sample preparations. The data-analyses are in some cases taken beyond ''conventional'' analysis of the Bragg scattering, as the diffuse scattering contains important information on D-D distances in disordered deuterides (Paper 3 and 4). A considerable part of this work is devoted to determination of the crystal structure of saturated Zr2Ni deuteride, Zr2NiD-4.8. The structure remained unsolved when only a few months remained of the scholarship. The route to the correct structure was found in the last moment. In Chapter II this winding road towards the structure determination is described; an interesting exercise in how to cope with triclinic superstructures of metal hydrides. The solution emerged by combining data from synchrotron radiation powder x-ray diffraction (SR-PXD), powder neutron diffraction (PND) and electron diffraction (ED). The triclinic crystal structure, described in space group P1 , is fully ordered with composition Zr4Ni2D9 (Zr2NiD4.5). The unit cell is doubled as compared to lower Zr2Ni deuterides due to a deuterium superstructure: asuper = a, bsuper = b - c, csuper = b + c. The deviation from higher symmetry is very small. The metal lattice is pseudo-I-centred tetragonal and the deuterium lattice is pseudo-C-centred monoclinic. The deuterium site preference in Zr2Ni

  13. Average and local structure of selected metal deuterides

    International Nuclear Information System (INIS)

    Soerby, Magnus H.

    2004-01-01

    The main topic of this thesis is improved understanding of site preference and mutual interactions of deuterium (D) atoms in selected metallic metal deuterides. The work was partly motivated by reports of abnormally short D-D distances in RENiInD1.33 compounds (RE = rear-earth element; D-D Υ square root 1.6 Aa) which show that the so-called Switendick criterion that demands a D-D separation of at least 2 Aa, is not a universal rule. The work is experimental and heavily based on scattering measurements using x-rays (lab and synchrotron) and neutrons. In order to enhance data quality, deuterium is almost exclusively used instead of natural hydrogen in sample preparations. The data-analyses are in some cases taken beyond ''conventional'' analysis of the Bragg scattering, as the diffuse scattering contains important information on D-D distances in disordered deuterides (Paper 3 and 4). A considerable part of this work is devoted to determination of the crystal structure of saturated Zr2Ni deuteride, Zr2NiD-4.8. The structure remained unsolved when only a few months remained of the scholarship. The route to the correct structure was found in the last moment. In Chapter II this winding road towards the structure determination is described; an interesting exercise in how to cope with triclinic superstructures of metal hydrides. The solution emerged by combining data from synchrotron radiation powder x-ray diffraction (SR-PXD), powder neutron diffraction (PND) and electron diffraction (ED). The triclinic crystal structure, described in space group P1 , is fully ordered with composition Zr4Ni2D9 (Zr2NiD4.5). The unit cell is doubled as compared to lower Zr2Ni deuterides due to a deuterium superstructure: asuper = a, bsuper = b - c, csuper = b + c. The deviation from higher symmetry is very small. The metal lattice is pseudo-I-centred tetragonal and the deuterium lattice is pseudo-C-centred monoclinic. The deuterium site preference in Zr2Ni deuterides at 1 bar D2 and

  14. Assessing diabetes support in adolescents: factor structure of the modified Diabetes Social Support Questionnaire (DSSQ-Friends)

    NARCIS (Netherlands)

    Malik, J.A.; Koot, H.M.

    2012-01-01

    Aims To determine the underlying factor structure of friends' enacted support behaviours for adolescents with Type 1 diabetes, confirm it in a second sample, delineate distinctive aspects of friends' support and test the reliability of resulting scale. Methods The study included a total of 434

  15. Promising SiC support for Pd catalyst in selective hydrogenation of acetylene to ethylene

    Science.gov (United States)

    Guo, Zhanglong; Liu, Yuefeng; Liu, Yan; Chu, Wei

    2018-06-01

    In this study, SiC supported Pd nanoparticles were found to be an efficient catalyst in acetylene selective hydrogenation reaction. The ethylene selectivity can be about 20% higher than that on Pd/TiO2 catalyst at the same acetylene conversion at 90%. Moreover, Pd/SiC catalyst showed a stable catalytic life at 65 °C with 80% ethylene selectivity. With the detailed characterization using temperature-programmed reduction (H2-TPR), powder X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), N2 adsorption/desorption analysis, CO-chemisorption and thermo-gravimetric analysis (TGA), it was found that SiC owns a lower surface area (22.9 m2/g) and a broad distribution of meso-/macro-porosity (from 5 to 65 nm), which enhanced the mass transfer during the chemical process at high reaction rate and decreased the residence time of ethylene on catalyst surface. Importantly, SiC support has the high thermal conductivity, which favored the rapid temperature homogenization through the catalyst bed and inhabited the over-hydrogenation of acetylene. The surface electronic density of Pd on Pd/SiC catalyst was higher than that on Pd/TiO2, which could promote desorption of ethylene from surface of the catalyst. TGA results confirmed a much less coke deposition on Pd/SiC catalyst.

  16. Selection of physiological parameters for optoelectronic system supporting behavioral therapy of autistic children

    Science.gov (United States)

    Landowska, A.; Karpienko, K.; Wróbel, M.; Jedrzejewska-Szczerska, M.

    2014-11-01

    In this article the procedure of selection of physiological parameters for optoelectronic system supporting behavioral therapy of autistic children is proposed. Authors designed and conducted an experiment in which a group of 30 health volunteers (16 females and 14 males) were examined. Under controlled conditions people were exposed to a stressful situation caused by the picture or sound (1kHz constant sound, which was gradually silenced and finished with a shot sound). For each of volunteers, a set of physiological parameters were recorded, including: skin conductance, heart rate, peripheral temperature, respiration rate and electromyography. The selected characteristics were measured in different locations in order to choose the most suitable one for the designed therapy supporting system. The bio-statistical analysis allowed us to discern the proper physiological parameters that are most associated to changes due to emotional state of a patient, such as: skin conductance, temperatures and respiration rate. This allowed us to design optoelectronic sensors network for supporting behavioral therapy of children with autism.

  17. Surface science study of selective ethylene epoxidation catalyzed by the Ag(110) surface: Structural sensitivity

    International Nuclear Information System (INIS)

    Campbell, C.T.

    1984-01-01

    The selective oxidation of ethylene to ethylene epoxide (C 2 H 4 +1/2O 2 →C 2 H 4 O) over Ag is the simplest example of kinetically controlled, selective heterogeneous catalysis. We have studied the steady-state kinetics and selectivity of this reaction for the first time on a clean, well-characterized Ag(110) surface by using a special apparatus which allows rapid (approx.20 s) transfer between a high-pressure catalytic microreactor and an ultrahigh vacuum surface analysis (AES, XPS, LEED, TDS) chamber. The effects of temperature and reactant pressures upon the rate and selectivity are virtually identical on Ag(110) and supported, high surface area Ag catalysts. The absolute specific rate (per Ag surface atom) is, however, some 100-fold higher for Ag(110) than for high surface area catalysts. This is related to the well-known structural sensitivity of this reaction. It is postulated that a small percentage of (110) planes (or [110]-like sites) are responsible for most of the catalytic activity of high surface area catalysts. The high activity of the (110) plane is attributed to its high sticking probability for dissociative oxygen adsorption, since the rate of ethylene epoxidation is shown in a related work [Ref. 1: C. T. Campbell and M. T. Paffett, Surf. Sci. (in press)] to be proportional to the coverage of atomically adsorbed oxygen at constant temperature and ethylene pressure

  18. Survival Prediction and Feature Selection in Patients with Breast Cancer Using Support Vector Regression

    Directory of Open Access Journals (Sweden)

    Shahrbanoo Goli

    2016-01-01

    Full Text Available The Support Vector Regression (SVR model has been broadly used for response prediction. However, few researchers have used SVR for survival analysis. In this study, a new SVR model is proposed and SVR with different kernels and the traditional Cox model are trained. The models are compared based on different performance measures. We also select the best subset of features using three feature selection methods: combination of SVR and statistical tests, univariate feature selection based on concordance index, and recursive feature elimination. The evaluations are performed using available medical datasets and also a Breast Cancer (BC dataset consisting of 573 patients who visited the Oncology Clinic of Hamadan province in Iran. Results show that, for the BC dataset, survival time can be predicted more accurately by linear SVR than nonlinear SVR. Based on the three feature selection methods, metastasis status, progesterone receptor status, and human epidermal growth factor receptor 2 status are the best features associated to survival. Also, according to the obtained results, performance of linear and nonlinear kernels is comparable. The proposed SVR model performs similar to or slightly better than other models. Also, SVR performs similar to or better than Cox when all features are included in model.

  19. Properties of Neurons in External Globus Pallidus Can Support Optimal Action Selection

    Science.gov (United States)

    Bogacz, Rafal; Martin Moraud, Eduardo; Abdi, Azzedine; Magill, Peter J.; Baufreton, Jérôme

    2016-01-01

    The external globus pallidus (GPe) is a key nucleus within basal ganglia circuits that are thought to be involved in action selection. A class of computational models assumes that, during action selection, the basal ganglia compute for all actions available in a given context the probabilities that they should be selected. These models suggest that a network of GPe and subthalamic nucleus (STN) neurons computes the normalization term in Bayes’ equation. In order to perform such computation, the GPe needs to send feedback to the STN equal to a particular function of the activity of STN neurons. However, the complex form of this function makes it unlikely that individual GPe neurons, or even a single GPe cell type, could compute it. Here, we demonstrate how this function could be computed within a network containing two types of GABAergic GPe projection neuron, so-called ‘prototypic’ and ‘arkypallidal’ neurons, that have different response properties in vivo and distinct connections. We compare our model predictions with the experimentally-reported connectivity and input-output functions (f-I curves) of the two populations of GPe neurons. We show that, together, these dichotomous cell types fulfil the requirements necessary to compute the function needed for optimal action selection. We conclude that, by virtue of their distinct response properties and connectivities, a network of arkypallidal and prototypic GPe neurons comprises a neural substrate capable of supporting the computation of the posterior probabilities of actions. PMID:27389780

  20. BIM-Based Decision Support System for Material Selection Based on Supplier Rating

    Directory of Open Access Journals (Sweden)

    Abiola Akanmu

    2015-12-01

    Full Text Available Material selection is a delicate process, typically hinged on a number of factors which can be either cost or environmental related. This process becomes more complicated when designers are faced with several material options of building elements and each option can be supplied by different suppliers whose selection criteria may affect the budgetary and environmental requirements of the project. This paper presents the development of a decision support system based on the integration of building information models, a modified harmony search algorithm and supplier performance rating. The system is capable of producing the cost and environmental implications of different material combinations or building designs. A case study is presented to illustrate the functionality of the developed system.

  1. Decision support tool for used oil regeneration technologies assessment and selection.

    Science.gov (United States)

    Khelifi, Olfa; Dalla Giovanna, Fabio; Vranes, Sanja; Lodolo, Andrea; Miertus, Stanislav

    2006-09-01

    Regeneration is the most efficient way of managing used oil. It saves money by preventing costly cleanups and liabilities that are associated with mismanagement of used oil, it helps to protect the environment and it produces a technically renewable resource by enabling an indefinite recycling potential. There are a variety of processes and licensors currently offering ways to deal with used oils. Selecting a regeneration technology for used oil involves "cross-matching" key criteria. Therefore, the first prototype of spent oil regeneration (SPORE), a decision support tool, has been developed to help decision-makers to assess the available technologies and select the preferred used oil regeneration options. The analysis is based on technical, economical and environmental criteria. These criteria are ranked to determine their relative importance for a particular used oil regeneration project. The multi-criteria decision analysis (MCDA) is the core of the SPORE using the PROMETHEE II algorithm.

  2. A decision-making support system to select forages according to environmental conditions in Colombia

    Directory of Open Access Journals (Sweden)

    Blanca Aurora Arce Barboza

    2013-07-01

    Full Text Available Low food supply is a major problem affecting a large percentage of the livestock population in Colombia and is largely associated to inappropriate choice of forage species; and thus not well adapted to the environmental conditions of a specific region. To mitigate this problem, without incurring increasing costs associated to changing environmental conditions, it is possible to match the adaptive capacity of species to the environment in which they grow. A decision support system was developed to select suitable forage species for a given environment. The system is based on the use of existing information about requirements of the species rather than specific experimentation. From the information gathered, a database was generated and implemented on ASP.NET in C # and SQL Server database. This system allows users to search and select pastures and forage species for specific soil and climatic conditions of a particular farm or region, through a user-friendly web platform.

  3. Structural analysis of TFTR TF coils and support structure for 6 Tesla operation

    International Nuclear Information System (INIS)

    Zatz, I.J.; Cargulia, G.; Lontai, L.

    1995-01-01

    The Tokamak Fusion Test Reactor (TFTR), which has been on line since December 1982, has successfully operated at its design Toroidal Field (TF) of 5.2 Tesla. Analysis of test data has indicated that the measured peak D-D neutron power in supershots may be scaled to the fourth power of TF field. Increasing the TF field to 6 Tesla provides the opportunity to explore the possibility of improving the D-T fusion yield, with the use of tritium. This increase in TF field from 5.2 to 6.0 Tesla increases the centering force by 33% and the out-of-plane force by 15% over previous peak operating levels. To examine the impact of the increase in loads on the TF coil, case and supporting structure, finite element analyses (FEA) were performed with and without the presence of loose bolts in the TF case. Note that the loose bolts comprise a fraction of the total number of bolts fastening the TF case sidewalls to the inner and outer rings of the case. Extensive analysis was performed using the FEA results in conjunction with supplementary calculations. Results are presented for the TF case, bolts, copper conductors, insulation, and supporting structure which indicate that the TF coils can successfully operate at 6 Tesla for a reasonable number of pulses

  4. Built structure identification in wildland fire decision support

    Science.gov (United States)

    David E. Calkin; Jon D. Rieck; Kevin D. Hyde; Jeffrey D. Kaiden

    2011-01-01

    Recent ex-urban development within the wildland interface has significantly increased the complexity and associated cost of federal wildland fire management in the United States. Rapid identification of built structures relative to probable fire spread can help to reduce that complexity and improve the performance of incident management teams. Approximate structure...

  5. Student Computer Use: Its Organizational Structure and Institutional Support.

    Science.gov (United States)

    Juska, Arunas; Paris, Arthur E.

    1993-01-01

    Examines the structure of undergraduate computing at a large private university, including patterns of use, impact of computer ownership and gender, and the bureaucratic structure in which usage is embedded. The profile of computer use uncovered in a survey is compared with reports offered by the institution and the trade press. (10 references)…

  6. A model of Piron's preparation-question structures in Ludwig's selection structures

    Science.gov (United States)

    Cattaneo, Gianpiero; Nisticò, Giuseppe

    1993-03-01

    We give a model of the basic Jauch-Piron (JP) approach to quantum physics, i.e., of “preparation-question structure” (with four basic axioms and without axioms C, P, A), in terms of Ludwig's “selection structure”; in the latter structure the primitive notion of “individual sample” of a physical entity is formally described (without making reference to any probability concept). Once we interpret Piron's concept of “question” in Ludwig's context of a selection structure, we find that there is no difficulty in formalizing notions such as “performable together questions”; moreover, results such as “ α ˜˜= α” or “( αδ Β)˜= α ˜▽ Β˜” can be formally proved. We develop the theory along the lines of the JP approach; the set of JP propositions is derived and it turns out to be a complete lattice, as happens in Piron's theory, but with a different physical interpretation of the lattice operations. Finally, we study some connections between the standard Ludwig foundation and our approach.

  7. Silver nanoparticles supported on alumina-​a highly efficient and selective nanocatalyst for imine reduction

    DEFF Research Database (Denmark)

    Poreddy, Raju; Garcia-Suarez, Eduardo J.; Riisager, Anders

    2014-01-01

    in the synthesis of secondary amines from primary amines in a tandem reaction protocol (oxidation–imination–reduction) using air and molecular hydrogen as oxidizing and reducing agents, respectively. The reported synthesis is performed under mild reaction conditions, which complies with the demands of modern...... organic synthesis. Due to the mild reaction conditions and high conversion as well as high selectivity, we consider that the utilization of silver nanoparticles supported on alumina represents an attractive and environmentally friendly alternative to the current synthesis of N-alkyl amines....

  8. Selected Examples of LDRD Projects Supporting Test Ban Treaty Verification and Nonproliferation

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Al-Ayat, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Walter, W. R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-02-23

    The Laboratory Directed Research and Development (LDRD) Program at the DOE National Laboratories was established to ensure the scientific and technical vitality of these institutions and to enhance the their ability to respond to evolving missions and anticipate national needs. LDRD allows the Laboratory directors to invest a percentage of their total annual budget in cutting-edge research and development projects within their mission areas. We highlight a selected set of LDRD-funded projects, in chronological order, that have helped provide capabilities, people and infrastructure that contributed greatly to our ability to respond to technical challenges in support of test ban treaty verification and nonproliferation.

  9. Nuclear R and D program in Indonesia and selection of future research reactor to support it

    International Nuclear Information System (INIS)

    Baiquni, A.; Subki, I.

    1981-01-01

    The nuclear R and D program selection decision is described as a phased program, each phase having its specific objective. The elements of each phase are identified and related with the objective, from which the activities of each element are also broadly outlined. To support the nuclear R and D program and to realize the objectives in each phase, the research facilities are also developed. A new nuclear development center housing a multipurpose reactor (MPR) and various laboratories are also described. The choice of the MPR and its criteria are also described briefly

  10. TOOL SUPPORT OF DECISION-MAKING AT SELECTION AND PERFORMANCE APPRAISAL TAKING INTO ACCOUNT MOTIVATION

    Directory of Open Access Journals (Sweden)

    Vadim Alexandrovich Lomazov

    2013-10-01

    Full Text Available The purpose of work consists in development of methods of information and algorithmic support of decision-making at an assessment and personnel selection taking into account motivation. The methods of a multicriteria assessment of alternatives and expert technologies are used as researching tools. The main result of the presented work is creation of the mathematical model that allows estimating a motivational orientation in the actions of the staff and job applicants. The scope of results of the work is the sphere of theoretical and applied questions of human resource management of the organizations.DOI: http://dx.doi.org/10.12731/2218-7405-2013-8-31

  11. Linear and nonlinear surface spectroscopy of supported size selected metal clusters and organic adsorbates

    Energy Technology Data Exchange (ETDEWEB)

    Thaemer, Martin Georg

    2012-03-08

    The spectroscopic investigation of supported size selected metal clusters over a wide wavelength range plays an important role for understanding their outstanding catalytic properties. The challenge which must be overcome to perform such measurements is the difficult detection of the weak spectroscopic signals from these samples. As a consequence, highly sensitive spectroscopic methods are applied, such as surface Cavity Ringdown Spectroscopy and surface Second Harmonic Generation Spectroscopy. The spectroscopic apparatus developed is shown to have a sensitivity which is high enough to detect sub-monolayer coverages of adsorbates on surfaces. In the measured spectra of small supported silver clusters of the sizes Ag{sub 4}2, Ag{sub 2}1, Ag{sub 9}, and Ag atoms a stepwise transition from particles with purely metallic character to particles with molecule-like properties can be observed within this size range.

  12. Interface Pattern Selection Criterion for Cellular Structures in Directional Solidification

    Science.gov (United States)

    Trivedi, R.; Tewari, S. N.; Kurtze, D.

    1999-01-01

    The aim of this investigation is to establish key scientific concepts that govern the selection of cellular and dendritic patterns during the directional solidification of alloys. We shall first address scientific concepts that are crucial in the selection of interface patterns. Next, the results of ground-based experimental studies in the Al-4.0 wt % Cu system will be described. Both experimental studies and theoretical calculations will be presented to establish the need for microgravity experiments.

  13. A Decision Support Concept for a construction design project – selecting the type of glass façade

    Directory of Open Access Journals (Sweden)

    Franjo Šimić

    2017-01-01

    Full Text Available The paper describes research into the possibility of developing a concept for supporting decisions in planning construction projects (one of the most important stages of construction project management. The focus is on supporting decisions in selecting the type of and solution for the glass façade in the main design. Materials and types of soluteons for a glass façade were analyzed and alternative solutions were obtained. The concept was developed in that it included relevant stakeholders in the decision-making process during the construction design. These stakeholders were the investor, architect, and construction contractor. The analysis was carried out and a hierarchical structure of objectives was formed as a goal tree. The criteria at the last hierarchical level were used to evaluate alternative solutions for the glass façade, and their weights were determined by all stakeholders using the AHP method (Analytic Hierarchy Process. Using PROMETHEE (Preference Ranking Method for Enrichment Evaluation, a comparison of alternative solutions for the glass façade was conducted and the alternatives were ranked according to the priorities for inclusion into the main design. The concept was tested by selecting a type of glass façade on a residential-commercial building in the city of Rijeka, Croatia.

  14. Evaluation of a prototype decision support system for selecting trench cap designs

    International Nuclear Information System (INIS)

    Paige, G.B.; Stone, J.J.; Lane, L.J.

    1996-01-01

    A computer-based prototype decision support system (PDSS) to assist the risk manager in selecting an appropriate trench cap design for waste disposal sites is evaluated. The selection of the open-quotes bestclose quotes design among feasible alternatives requires consideration of multiple and often conflicting objectives. The methodology used in the selection process consists of. selecting and parameterizing decision variables, using data, simulation models, or expert opinion; selecting feasible trench cap design alternatives; ordering the decision variables and ranking the design alternatives. The simulation models incorporated in the PDSS are the Hydrologic Evaluation of Landfill Performance (HELP) model which is used to simulate the trench cap water balance and the Chemicals, Runoff, and Erosion from Agricultural Management Systems (CREAMS) erosion component that is used to simulate trench cap erosion. The decision model is based on multi-objective decision theory and uses a unique approach to order the decision variables and rank the design alternatives. The PDSS is evaluated using the Hill Air Force Base landfill cover demonstration project. The water balance and surface erosion of four alternative landfill cover designs were monitored for a 4-yr period. Two of the cover designs were used to calibrate and test the simulation models. The results of the PDSS, using both data from all four designs and long-term simulations from two of the designs, illustrate the relative advantages of each of the cover designs and which cover is the open-quotes bestclose quotes alternative for a given set of criteria and a particular importance order of those decision criteria. 22 refs., 6 figs., 4 tabs

  15. Elmo Bumpy Torus proof of principle, Phase II: Title 1 report. Volume IX. Support structure

    International Nuclear Information System (INIS)

    Conlee, J.L.

    1982-01-01

    The EBT-P support structure provides structural support for the 36 mirror coil magnets, magnet protection system, the toroidal vessel, and much of the device ancillary equipment. The structure is comprised of a primary support and a superstructure. The primary support is a reinforced concrete ring located directly inboard of the torus and is supported by nine columns. The toroidal vessel and the mirror coil magnets are cantilevered from the ring with the centerline of the torus located eight feet above the floor. The superstructure is an aluminum truss structure that rests on the concrete ring. The superstructure provides support for the device ancillary equipment. Engineering drawings of the support structure are given

  16. Application of a collaborative modelling and strategic fuzzy decision support system for selecting appropriate resilience strategies for seaport operations

    Directory of Open Access Journals (Sweden)

    Andrew John

    2014-06-01

    Full Text Available The selection of an appropriate resilience investment strategy to optimize the operational efficiency of a seaport is a challenging task given that many criteria need to be considered and modelled under an uncertain environment. The design of such a complex decision system consists of many subjective and imprecise parameters contained in different quantitative and qualitative forms. This paper proposes a fuzzy multi-attribute decision making methodology for the selection of an appropriate resilience investment strategy in a succinct and straightforward manner. The decision support model allows for a collaborative modelling of the system by multiple analysts in a group decision making process. Fuzzy analytical hierarchy process (FAHP was utilized to analyse the complex structure of the system to obtain the weights of all the criteria while fuzzy technique for order of preference by similarity to ideal solution (TOPSIS was employed to facilitate the ranking process of the resilience strategies. Given that it is often financially difficult to invest in all the resilience strategies, it is envisaged that the proposed approach could provide decision makers with a flexible and transparent tool for selecting appropriate resilience strategies aimed at increasing the resilience of seaport operations.

  17. Effective work-life balance support for various household structures

    NARCIS (Netherlands)

    Brummelhuis, L.L. ten; Lippe, T. van der

    2010-01-01

    Today’s workforce encompasses a wide variety of employees with specifi c needs and resources when it comes to balancing work and life roles. Our study explores whether various types of work-life balance support measures improve employee helping behavior and performance among single employees,

  18. Operating System Support for Shared Hardware Data Structures

    Science.gov (United States)

    2013-01-31

    2.1.4 Systolic Priority Queues . . . . . . . . . . . . . . . . . . . . . . . . . 16 2.1.5 Abstract Datatype Processors...intelligent software support is necessary to achieve good perfor- mance from HWDSs in the presence of overflow and sharing. 2.1.5 Abstract Datatype ...abstract datatype processors, which accelerate data types with mechanisms and performance similar to HWDSs. Abstract datatype instructions can reduce

  19. Light alkane (mixed feed selective dehydrogenation using bi-metallic zeolite supported catalyst

    Directory of Open Access Journals (Sweden)

    Zeeshan Nawaz

    2009-12-01

    Full Text Available Light alkanes are the important intermediates of many refinery processes and their catalytic dehydrogenation gives corresponding alkenes. The aim behind this experimentation is to investigate reaction behavior of mixed alkanes during direct catalytic dehydrogenation and emphasis has been given to enhance propene. Bi-metallic zeolite supported catalyst Pt-Sn/ZSM-5 was prepared by sequentional impregnation method and characterized by BET, EDS and XRD. Direct dehydrogenation reaction is highly endothermic and its conversion is thermodynamically limited. Results showed that the increase in temperature increases the conversion to some extent but there is no overall effect on selectivity of propene. Increase in time-on-stream (TOS remarkably improves propene selectivity at the expense of lower conversion. The performances of bi-metallic zeolite based catalyst largely affected by coke deposition. The presence of butane and ethane adversely affected propane conversion. Optimum propene selectivity is about 48 %, obtained at 600 oC and time-on-stream 10 h.

  20. OPEN SPATIAL DECISION SUPPORT SYSTEM: CASE FOR RADIOACTIVE WASTE DISPOSAL SITE SELECTION

    Directory of Open Access Journals (Sweden)

    Dario Perković

    2012-07-01

    Full Text Available In recent years the scientific and professional circles frequently discussed about radioactive waste and site selection for radioactive waste disposal. This issue will be further updated with accession of Republic of Croatia to the European Union and the only issue is politicized view of the fact that nuclear power plant Krško Croatia shares with neighbouring Republic of Slovenia. All the necessary studies have been made and these are attended by experts from different areas. Also, all Croatian residents should be familiar with this subject matter in a manner accessible to the general public through all available media. There are some questions: What are the institutions have taken on the issue of informing the public and can it be enough? When selecting a suitable site, with many parameters, the basic element is suitable geological formation, although the landfill must be socially acceptable. Well established methods used in the selection of eligible areas are multicriteria decision analysis (MCDA, geographic information system (GIS and combined GIS-MCDA method. The application of these methods is of great help in making decisions about the location of disposal of radioactive waste. Presentation of results, designed in the form of an open spatial decision support system, could help in education and informing the general public (the paper is published in Croatian.

  1. Feature Selection and Parameter Optimization of Support Vector Machines Based on Modified Artificial Fish Swarm Algorithms

    Directory of Open Access Journals (Sweden)

    Kuan-Cheng Lin

    2015-01-01

    Full Text Available Rapid advances in information and communication technology have made ubiquitous computing and the Internet of Things popular and practicable. These applications create enormous volumes of data, which are available for analysis and classification as an aid to decision-making. Among the classification methods used to deal with big data, feature selection has proven particularly effective. One common approach involves searching through a subset of the features that are the most relevant to the topic or represent the most accurate description of the dataset. Unfortunately, searching through this kind of subset is a combinatorial problem that can be very time consuming. Meaheuristic algorithms are commonly used to facilitate the selection of features. The artificial fish swarm algorithm (AFSA employs the intelligence underlying fish swarming behavior as a means to overcome optimization of combinatorial problems. AFSA has proven highly successful in a diversity of applications; however, there remain shortcomings, such as the likelihood of falling into a local optimum and a lack of multiplicity. This study proposes a modified AFSA (MAFSA to improve feature selection and parameter optimization for support vector machine classifiers. Experiment results demonstrate the superiority of MAFSA in classification accuracy using subsets with fewer features for given UCI datasets, compared to the original FASA.

  2. Mechanical frequency selectivity of an artificial basilar membrane using a beam array with narrow supports

    International Nuclear Information System (INIS)

    Kim, Sangwon; Jang, Jongmoon; Choi, Hongsoo; Song, Won Joon; Jang, Jeong Hun

    2013-01-01

    The study presented in this paper assessed the frequency selectivity of an artificial basilar membrane (ABM) constructed using a piezoelectric beam array with narrow supports. Three ABM samples were constructed. Each ABM contained 16 beams with various lengths in a one-dimensional array. To experimentally assess the frequency selectivity of the ABM, mechanical vibration induced either by an electrical or an acoustic stimulus was measured with a scanning laser-Doppler vibrometer. The electro-mechanical and acousto-mechanical transfer functions were defined for the same purpose. The tonotopy of each beam array was visualized by post-processing the experimental results. Finite element analyses were conducted to numerically compute the resonance frequencies, identify the associated vibrational modes, and evaluate the harmonic responses of the beams. The influence of the residual stresses existing in the beams was reflected in the geometric models by introducing three different levels of arc-shaped lateral deformations in the beams. The harmonic analyses revealed that each beam of the ABM samples presented independent band-pass characteristics. The experiments and simulations commonly showed a frequency selectivity of the fabricated ABMs in the range of 2–20 kHz. Therefore, the device is suitable for development of a totally implantable artificial cochlea, implementing a mechanical frequency analyzer. This work is part of research to develop a prototype of a totally implantable artificial cochlea. (paper)

  3. Improving breast cancer classification with mammography, supported on an appropriate variable selection analysis

    Science.gov (United States)

    Pérez, Noel; Guevara, Miguel A.; Silva, Augusto

    2013-02-01

    This work addresses the issue of variable selection within the context of breast cancer classification with mammography. A comprehensive repository of feature vectors was used including a hybrid subset gathering image-based and clinical features. It aimed to gather experimental evidence of variable selection in terms of cardinality, type and find a classification scheme that provides the best performance over the Area Under Receiver Operating Characteristics Curve (AUC) scores using the ranked features subset. We evaluated and classified a total of 300 subsets of features formed by the application of Chi-Square Discretization, Information-Gain, One-Rule and RELIEF methods in association with Feed-Forward Backpropagation Neural Network (FFBP), Support Vector Machine (SVM) and Decision Tree J48 (DTJ48) Machine Learning Algorithms (MLA) for a comparative performance evaluation based on AUC scores. A variable selection analysis was performed for Single-View Ranking and Multi-View Ranking groups of features. Features subsets representing Microcalcifications (MCs), Masses and both MCs and Masses lesions achieved AUC scores of 0.91, 0.954 and 0.934 respectively. Experimental evidence demonstrated that classification performance was improved by combining image-based and clinical features. The most important clinical and image-based features were StromaDistortion and Circularity respectively. Other less important but worth to use due to its consistency were Contrast, Perimeter, Microcalcification, Correlation and Elongation.

  4. Selective attention supports working memory maintenance by modulating perceptual processing of distractors.

    Science.gov (United States)

    Sreenivasan, Kartik K; Jha, Amishi P

    2007-01-01

    Selective attention has been shown to bias sensory processing in favor of relevant stimuli and against irrelevant or distracting stimuli in perceptual tasks. Increasing evidence suggests that selective attention plays an important role during working memory maintenance, possibly by biasing sensory processing in favor of to-be-remembered items. In the current study, we investigated whether selective attention may also support working memory by biasing processing against irrelevant and potentially distracting information. Event-related potentials (ERPs) were recorded while subjects (n = 22) performed a delayed-recognition task for faces and shoes. The delay period was filled with face or shoe distractors. Behavioral performance was impaired when distractors were congruent with the working memory domain (e.g., face distractor during working memory for faces) relative to when distractors were incongruent with the working memory domain (e.g., face distractor during shoe working memory). If attentional biasing against distractor processing is indeed functionally relevant in supporting working memory maintenance, perceptual processing of distractors is predicted to be attenuated when distractors are more behaviorally intrusive relative to when they are nonintrusive. As such, we predicted that perceptual processing of distracting faces, as measured by the face-sensitive N170 ERP component, would be reduced in the context of congruent (face) working memory relative to incongruent (shoe) working memory. The N170 elicited by distracting faces demonstrated reduced amplitude during congruent versus incongruent working memory. These results suggest that perceptual processing of distracting faces may be attenuated due to attentional biasing against sensory processing of distractors that are most behaviorally intrusive during working memory maintenance.

  5. Integral Public Activities as a Support to the Site Selection Process for LILW Repository

    International Nuclear Information System (INIS)

    Zeleznik, N.; Kralj, M.

    2008-01-01

    The first site selection process for low and intermediate level radioactive waste (LILW) repository took place between 1990 and 1993 in Slovenia was stopped unsuccessfully with very strong public opposition at local level, followed by political withdrawal on national level. As one of the consequences ARAO started to develop new approach to the site selection based also on the findings from sociology, psychology and other human sciences. The recommendations on public involvement and transparency were so strong that ARAO started with first limited public relation (PR) activities which later grew to the PR process which supports all technical activities in ARAO. Presently the PR process covers communication, information and research activities and assures careful planning, prompt responds and involvement of the highest responsible persons at ARAO. Integral public relation activities are divided in several parts. Majority of activities support the on-going site selection process where activities are presently focused on functioning of local partnerships developed as a basic communication tool to involve as much citizens and public as possible on local level. Presently two local partnerships are working in Krsko and Brezice community with clear role to enhance public involvement according to Aarchus convention. Each of the partnerships is organized in a specific way adjusted to the local needs. Communication activities are organized also for different other projects and are preparing the necessary basis for the work with different groups of stake holders and in different situations. As a foundation very broad information material, such as books, leaflets, reports, magazines, video cassettes, CD and DVD on the radioactive waste management is prepared and used for different purposes. We also try to be proactive with web pages and have a well organized visitors' center. Improvement of public relation process is achieved through constant survey and feed-back information

  6. An ArcGIS decision support tool for artificial reefs site selection (ArcGIS ARSS)

    Science.gov (United States)

    Stylianou, Stavros; Zodiatis, George

    2017-04-01

    Although the use and benefits of artificial reefs, both socio-economic and environmental, have been recognized with research and national development programmes worldwide their development is rarely subjected to a rigorous site selection process and the majority of the projects use the traditional (non-GIS) approach, based on trial and error mode. Recent studies have shown that the use of Geographic Information Systems, unlike to traditional methods, for the identification of suitable areas for artificial reefs siting seems to offer a number of distinct advantages minimizing possible errors, time and cost. A decision support tool (DSS) has been developed based on the existing knowledge, the multi-criteria decision analysis techniques and the GIS approach used in previous studies in order to help the stakeholders to identify the optimal locations for artificial reefs deployment on the basis of the physical, biological, oceanographic and socio-economic features of the sites. The tool provides to the users the ability to produce a final report with the results and suitability maps. The ArcGIS ARSS support tool runs within the existing ArcMap 10.2.x environment and for the development the VB .NET high level programming language has been used along with ArcObjects 10.2.x. Two local-scale case studies were conducted in order to test the application of the tool focusing on artificial reef siting. The results obtained from the case studies have shown that the tool can be successfully integrated within the site selection process in order to select objectively the optimal site for artificial reefs deployment.

  7. Protein structure and ionic selectivity in calcium channels: Selectivity filter size, not shape, matters

    OpenAIRE

    Malasics, Attila; Gillespie, Dirk; Nonner, Wolfgang; Henderson, Douglas; Eisenberg, Bob; Boda, Dezső

    2009-01-01

    Calcium channels have highly charged selectivity filters (4 COO− groups) that attract cations in to balance this charge and minimize free energy, forcing the cations (Na+ and Ca2+) to compete for space in the filter. A reduced model was developed to better understand the mechanism of ion selectivity in calcium channels. The charge/space competition (CSC) mechanism implies that Ca2+ is more efficient in balancing the charge of the filter because it provides twice the charge as Na+ while occupy...

  8. Unusual lipid structures selectively reduce the toxicity of amphotericin B

    International Nuclear Information System (INIS)

    Janoff, A.S.; Boni, L.T.; Popescu, M.C.

    1988-01-01

    Ribbon-like structures result when amphotericin B interacts with lipid in an aqueous environment. At high ratios of amphotericin to lipid these structures, which are lipid-stabilized amphotericin aggregates, become prevalent resulting in a dramatic attenuation of amphotericin-mediated mammalian cell, but not fungal cell, toxicity. Studies utilizing freeze-etch electron microscopy, differential scanning calorimetry, 31 P NMR, x-ray diffraction, and optical spectroscopy revealed that this toxicity attenuation is related to the macromolecular structure of the complexes in a definable fashion. It is likely that amphotericin in this specific form will have a much improved therapeutic utility

  9. Protein structure and ionic selectivity in calcium channels: selectivity filter size, not shape, matters.

    Science.gov (United States)

    Malasics, Attila; Gillespie, Dirk; Nonner, Wolfgang; Henderson, Douglas; Eisenberg, Bob; Boda, Dezso

    2009-12-01

    Calcium channels have highly charged selectivity filters (4 COO(-) groups) that attract cations in to balance this charge and minimize free energy, forcing the cations (Na(+) and Ca(2+)) to compete for space in the filter. A reduced model was developed to better understand the mechanism of ion selectivity in calcium channels. The charge/space competition (CSC) mechanism implies that Ca(2+) is more efficient in balancing the charge of the filter because it provides twice the charge as Na(+) while occupying the same space. The CSC mechanism further implies that the main determinant of Ca(2+) versus Na(+) selectivity is the density of charged particles in the selectivity filter, i.e., the volume of the filter (after fixing the number of charged groups in the filter). In this paper we test this hypothesis by changing filter length and/or radius (shape) of the cylindrical selectivity filter of our reduced model. We show that varying volume and shape together has substantially stronger effects than varying shape alone with volume fixed. Our simulations show the importance of depletion zones of ions in determining channel conductance calculated with the integrated Nernst-Planck equation. We show that confining the protein side chains with soft or hard walls does not influence selectivity.

  10. Evaluation Problem versus Selection Problem in Organizational Structures

    NARCIS (Netherlands)

    S.S. Ficco (Stefano); V.A. Karamychev (Vladimir)

    2005-01-01

    textabstractWe consider a hierarchical organization with two fully rational agents. The goal of the organization is that of selecting the best alternative out of several available, and agents are heterogenous in the accuracy with which they screen the alternatives. We show that, if internal

  11. Electronic structure of graphene- and BN-supported phosphorene

    Science.gov (United States)

    Davletshin, Artur R.; Ustiuzhanina, Svetlana V.; Kistanov, Andrey A.; Saadatmand, Danial; Dmitriev, Sergey V.; Zhou, Kun; Korznikova, Elena A.

    2018-04-01

    By using first-principles calculations, the effects of graphene and boron nitride (BN) substrates on the electronic properties of phosphorene are studied. Graphene-supported phosphorene is found to be metallic, while the BN-supported phosphorene is a semiconductor with a moderate band gap of 1.02 eV. Furthermore, the effects of the van der Waals interactions between the phosphorene and graphene or BN layers by means of the interlayer distance change are investigated. It is shown that the interlayer distance change leads to significant band gap size modulations and direct-indirect band gap transitions in the phosphorene-BN heterostructure. The presented band gap engineering of phosphorene may be a powerful technique for the fabrication of high-performance phosphorene-based nanodevices.

  12. Experimental study of flow patterns near tube support structures

    International Nuclear Information System (INIS)

    Rummens, H.E.C.; Turner, C.W.

    1994-07-01

    Extensive blockage of broached support plates in steam generators has occurred at the Bruce A Nuclear Generating Station (NGS), forcing unit derating in 1988 March. Blockage has also been found on the lower broached plates of the Pickering B and Point Lepreau NGSs. Water chemistry and operating conditions are known to influence fouling directly. We suspect that flow patterns also play a role, that these patterns are influenced by the geometry of steam generator (SG) components, and that particularly the broached plate design actively creates an environment favorable to deposition. Experiments are in progress to examine the flow patterns near various tube supports: the broached plate, two types of lattice bars, and the formed bars. Preliminary tests in an air/water loop with 1/2- and 7-tube SG mockups containing the tube supports have been completed. Flow patterns were visualized using injected air bubbles. Local velocities and turbulence levels were measured using a laser technique, which confirmed observations of flow recirculation and stagnation. Axial pressure profiles were measured to determine overall resistance coefficients, and to identify local pressure extremes. Some visualization tests were also carried out on an artificially fouled broached plate. Based on results to date, several deposition mechanisms are proposed: deposition of particles in stagnant regions, deposition of solubles due to flashing in low-pressure regions, and deposition in smaller channels due to steam migration toward larger channels. A qualitative assessment of the tube support designs based on these mechanisms implies that the relative resistances to fouling are: (WORST) broach plate << lattice bars << formed bars (BEST). As the air/water simulation shows only hydraulic flow patterns, further tests will be done in a simple liquid/vapor Freon loop to examine thermal effects. (author). 3 refs., 10 figs

  13. Effective work-life balance support for various household structures

    OpenAIRE

    Brummelhuis, L.L. ten; Lippe, T. van der

    2010-01-01

    Today’s workforce encompasses a wide variety of employees with specifi c needs and resources when it comes to balancing work and life roles. Our study explores whether various types of work-life balance support measures improve employee helping behavior and performance among single employees, employees with a partner, and employees with a partner and children. Using a sample of 482 employees at 24 organizations, the results showed that the organization’s work-family culture improved work perf...

  14. Content Consumption and Hierarchical Structures of Web-Supported Courses

    Science.gov (United States)

    Hershkovitz, Arnon; Hardof-Jaffe, Sharon; Nachmias, Rafi

    2014-01-01

    This study presents an empirical investigation of the relationship between the hierarchical structure of content delivered to students within a Learning Management System (LMS) and its actual consumption. To this end, campus-wide data relating to 1,203 courses were collected from the LMS' servers and were subsequently analyzed using data mining…

  15. Probabilistic structural analysis methods for select space propulsion system components

    Science.gov (United States)

    Millwater, H. R.; Cruse, T. A.

    1989-01-01

    The Probabilistic Structural Analysis Methods (PSAM) project developed at the Southwest Research Institute integrates state-of-the-art structural analysis techniques with probability theory for the design and analysis of complex large-scale engineering structures. An advanced efficient software system (NESSUS) capable of performing complex probabilistic analysis has been developed. NESSUS contains a number of software components to perform probabilistic analysis of structures. These components include: an expert system, a probabilistic finite element code, a probabilistic boundary element code and a fast probability integrator. The NESSUS software system is shown. An expert system is included to capture and utilize PSAM knowledge and experience. NESSUS/EXPERT is an interactive menu-driven expert system that provides information to assist in the use of the probabilistic finite element code NESSUS/FEM and the fast probability integrator (FPI). The expert system menu structure is summarized. The NESSUS system contains a state-of-the-art nonlinear probabilistic finite element code, NESSUS/FEM, to determine the structural response and sensitivities. A broad range of analysis capabilities and an extensive element library is present.

  16. Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

    International Nuclear Information System (INIS)

    Deng, Xiaoyi; Gujjar, Ramesh; El Mazouni, Farah; Kaminsky, Werner; Malmquist, Nicholas A.; Goldsmith, Elizabeth J.; Rathod, Pradipsinh K.; Phillips, Margaret A.

    2009-01-01

    Malaria remains a major global health burden and current drug therapies are compromised by resistance. Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) was validated as a new drug target through the identification of potent and selective triazolopyrimidine-based DHODH inhibitors with anti-malarial activity in vivo. Here we report x-ray structure determination of PfDHODH bound to three inhibitors from this series, representing the first of the enzyme bound to malaria specific inhibitors. We demonstrate that conformational flexibility results in an unexpected binding mode identifying a new hydrophobic pocket on the enzyme. Importantly this plasticity allows PfDHODH to bind inhibitors from different chemical classes and to accommodate inhibitor modifications during lead optimization, increasing the value of PfDHODH as a drug target. A second discovery, based on small molecule crystallography, is that the triazolopyrimidines populate a resonance form that promotes charge separation. These intrinsic dipoles allow formation of energetically favorable H-bond interactions with the enzyme. The importance of delocalization to binding affinity was supported by site-directed mutagenesis and the demonstration that triazolopyrimidine analogs that lack this intrinsic dipole are inactive. Finally, the PfDHODH-triazolopyrimidine bound structures provide considerable new insight into species-selective inhibitor binding in this enzyme family. Together, these studies will directly impact efforts to exploit PfDHODH for the development of anti-malarial chemotherapy.

  17. Ni–Sn-Supported ZrO2 Catalysts Modified by Indium for Selective CO2 Hydrogenation to Methanol

    KAUST Repository

    Hengne, Amol Mahalingappa

    2018-04-02

    Ni and NiSn supported on zirconia (ZrO2) and on indium (In)-incorporated zirconia (InZrO2) catalysts were prepared by a wet chemical reduction route and tested for hydrogenation of CO2 to methanol in a fixed-bed isothermal flow reactor at 250 °C. The mono-metallic Ni (5%Ni/ZrO2) catalysts showed a very high selectivity for methane (99%) during CO2 hydrogenation. Introduction of Sn to this material with the following formulation 5Ni5Sn/ZrO2 (5% Ni-5% Sn/ZrO2) showed the rate of methanol formation to be 0.0417 μmol/(gcat·s) with 54% selectivity. Furthermore, the combination NiSn supported on InZrO2 (5Ni5Sn/10InZrO2) exhibited a rate of methanol formation 10 times higher than that on 5Ni/ZrO2 (0.1043 μmol/(gcat·s)) with 99% selectivity for methanol. All of these catalysts were characterized by X-ray diffraction, high-resolution transmission electron microscopy (HRTEM), scanning transmission electron microscopy (STEM), X-ray photoelectron spectroscopy, CO2-temperature-programmed desorption, and density functional theory (DFT) studies. Addition of Sn to Ni catalysts resulted in the formation of a NiSn alloy. The NiSn alloy particle size was kept in the range of 10–15 nm, which was evidenced by HRTEM study. DFT analysis was carried out to identify the surface composition as well as the structural location of each element on the surface in three compositions investigated, namely, Ni28Sn27, Ni18Sn37, and Ni37Sn18 bimetallic nanoclusters, and results were in agreement with the STEM and electron energy-loss spectroscopy results. Also, the introduction of “Sn” and “In” helped improve the reducibility of Ni oxide and the basic strength of catalysts. Considerable details of the catalytic and structural properties of the Ni, NiSn, and NiSnIn catalyst systems were elucidated. These observations were decisive for achieving a highly efficient formation rate of methanol via CO2 by the H2 reduction process with high methanol selectivity.

  18. Design and heat load analysis of support structure of CR superconducting dipole magnet for FAIR

    International Nuclear Information System (INIS)

    Zhu Yinfeng; Wu Songtao; Wu Weiyue; Xu Houchang; Liu Changle

    2008-01-01

    In order to meet the requirement of the Collector ring (CR) dipole superconducting magnet of FAIR in the process of operation, meanwhile, and to ensure the heat loads coming from the support structures to be lower than the design demands, the 3D models of support structures have been constructed with CATIA, then the calculation of low-temperature heat-load and the structure analysis have been done with ANSYS, the support structure material, 316LN+G10, is decided according to the heat-load calculation and the structure optimization, these results are necessary for manufacturing the formal magnet. (authors)

  19. Structure and magnetic properties of nickel nanoparticles preparedby selective leaching

    Czech Academy of Sciences Publication Activity Database

    Michalcová, A.; Svobodová, P.; Nováková, R.; Len, A.; Heczko, Oleg; Vojtěch, D.; Marek, I.; Novák, P.

    2014-01-01

    Roč. 137, Dec (2014), s. 221-224 ISSN 0167-577X R&D Projects: GA ČR(CZ) GA14-03044S Institutional support: RVO:68378271 Keywords : nanoparticles * magnetic materials * metals and alloys * route * size Subject RIV: JG - Metallurgy Impact factor: 2.489, year: 2014

  20. Light scattering measurements supporting helical structures for chromatin in solution.

    Science.gov (United States)

    Campbell, A M; Cotter, R I; Pardon, J F

    1978-05-01

    Laser light scattering measurements have been made on a series of polynucleosomes containing from 50 to 150 nucleosomes. Radii of gyration have been determined as a function of polynucleosome length for different ionic strength solutions. The results suggest that at low ionic strength the chromatin adopts a loosely helical structure rather than a random coil. The helix becomes more regular on increasing the ionic strength, the dimension resembling those proposed by Finch and Klug for their solenoid model.

  1. ALICE's main austenitic stainless steel support structure (the Space Frame)

    CERN Multimedia

    Maximilien Brice

    2006-01-01

    This structure is constructed to hold the large volume detectors, such as the Time Projection Chamber, Transition Radiation Detector and Time of Flight inside the ALICE solenoid magnet. After the final assembly at CERN, two large mobile cranes were needed for the job of lifting and turning the 14 tonne frame onto its side. Once shifted, it was placed in Building SX2, one of the surface assembly areas designated for ALICE.

  2. Numerical evaluation of micro-structural parameters of porous supports in metal-supported solid oxide fuel cells

    DEFF Research Database (Denmark)

    Reiss, Georg; Frandsen, Henrik Lund; Brandstätter, Wilhelm

    2014-01-01

    Metallic supported Solid Oxide Fuel Cells (SOFCs) are considered as a durable and cost effective alternative to the state-of-the-art ceramic supported cell designs. In order to understand the mass and charge transport in the metal-support of this new type of cell a novel technique involving X......-ray tomography and micro-structural modelling is presented in this work. The simulation technique comprises a novel treatment of the boundary conditions, which leads to more accurate effective transport parameters compared to those, which can be achieved with the conventional homogenisation procedures....... Furthermore, the porosity distribution in the metal-support was determined, which provided information about the inhomogeneous nature of the material. In addition to that, transport parameters for two identified, different dense layers of the metal-support are evaluated separately. The results...

  3. Tunable and selective hydrogenation of furfural to furfuryl alcohol and cyclopentanone over Pt supported on biomass-derived porous heteroatom doped carbon.

    Science.gov (United States)

    Liu, Xiuyun; Zhang, Bo; Fei, Benhua; Chen, Xiufang; Zhang, Junyi; Mu, Xindong

    2017-09-21

    The search for and exploitation of efficient catalytic systems for selective conversion of furfural into various high value-added chemicals remains a huge challenge for green synthesis in the chemical industry. Here, novel Pt nanoparticles supported on bamboo shoot-derived porous heteroatom doped carbon materials were designed as highly active catalysts for controlled hydrogenation of furfural in aqueous media. The porous heteroatom doped carbon supported Pt catalysts were endowed with a large surface area with a hierarchical porous structure, a high content of nitrogen and oxygen functionalities, a high dispersion of the Pt nanoparticles, good water dispersibility and reaction stability. Benefiting from these features, the novel Pt catalysts displayed a high activity and controlled tunable selectivity for furfural hydrogenation to produce furfuryl alcohol and cyclopentanone in water. The product selectivity could be easily modulated by controlling the carbonization temperature of the porous heteroatom doped carbon support and the reaction conditions (temperature and H 2 pressure). Under mild conditions (100 °C, 1 MPa H 2 ), furfuryl alcohol was obtained in water with complete conversion of the furfural and an impressive furfuryl alcohol selectivity of >99% in the presence of Pt/NC-BS-500. A higher reaction temperature, in water, favored rearrangement of the furfural (FFA) with Pt/NC-BS-800 as the catalyst, which resulted in a high cyclopentanone yield of >76% at 150 °C and 3 MPa H 2 . The surface properties and pore structure of the heteroatom doped carbon support, adjusted using the carbonization temperature, might determine the interactions between the Pt nanoparticles, carbon support and catalytic reactants in water, which in turn could have led to a good selectivity control. The effect of different reaction temperatures and reaction times on the product selectivity was also explored. Combined with exploration of the distribution of the reaction products, a

  4. Looking forward, not back: Supporting structuralism in the present.

    Science.gov (United States)

    McKenzie, Kerry

    2016-10-01

    The view that the fundamental kind properties are intrinsic properties enjoys reflexive endorsement by most metaphysicians of science. But ontic structural realists deny that there are any fundamental intrinsic properties at all. Given that structuralists distrust intuition as a guide to truth, and given that we currently lack a fundamental physical theory that we could consult instead to order settle the issue, it might seem as if there is simply nowhere for this debate to go at present. However, I will argue that there exists an as-yet untapped resource for arguing for ontic structuralism - namely, the way that fundamentality is conceptualized in our most fundamental physical frameworks. By arguing that physical objects must be subject to the 'Goldilock's principle' if they are to count as fundamental at all, I argue that we can no longer view the majority of properties defining them as intrinsic. As such, ontic structural realism can be regarded as the most promising metaphysics for fundamental physics, and that this is so even though we do not yet claim to know precisely what that fundamental physics is. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. A new support structure for high field magnets

    International Nuclear Information System (INIS)

    Bish, P.S.; Caspi, S.; Dietderich, D.R.; Gourlay, S.A.; Hafalia, R.R.; Hannaford, R.; Lietzke, A.F.; Liggins, N.; McInturff, A.D.; Sabbi, G.L.; Scanlan, R.M.; O'Neill, J.; Swanson, J.H

    2001-01-01

    Pre-stress of superconducting magnets can be applied directly through the magnet yoke structure. We have replaced the collar functionality in our 14 Tesla R and D Nb 3 Sn dipole magnets with an assembly procedure based on an aluminum shell and bladders. Bladders, placed between the coil pack and surrounding yoke inside the shell, are pressurized up to 10 ksi [70 MPa] to create an interference gap. Keys placed into the interference gap replace the bladder functionality. Following the assembly, the bladders are deflated and removed. Strain gauges mounted directly on the shell are used to monitor the stress of the entire magnet structure, thereby providing a high degree of pre-stress control without the need for high tolerances. During assembly, a force of 8.2 x 10 5 lbs/ft [12 MN/m] is generated by the bladders and the stress in the 1.57 inch [40mm] aluminum shell reaches 20.3 ksi [140 MPa]. During cool-down the thermal expansion difference between shell and yoke generates an additional compressive force of 6.85 x 10 5 lbs/ft [10 MN/m], corresponding to a final stress in the shell of 39.2 ksi [270 MPa]. Pre-stress conditions are sufficient for 16 T before the coils separate at the bore. Bladders have now been used in the assembly and disassembly of two 14 T magnets. This paper describes the magnet structure, assembly procedure and test results

  6. [Preparation and structural analysis of diatomite-supported SPFS flocculant].

    Science.gov (United States)

    Zheng, Huai-li; Fang, Hui-li; Jiang, Shao-jie; Yang, Chun; Ma, Jiang-ya; Zhang, Zhao-qing

    2011-07-01

    In the presetn study, polymerized ferric sulphate (PFS) flocculant was prepared and tested. In the preparation of PFS flocculant, industrial by-product ferrous sulfate heptahydrate (FeSO4.7H2O) was reused as the main material. By composition with diatomite and drying up at certain temperature in vacuum drying oven, solid PFS flocculant was produced. Structural characteristics of the new flocculant product were examined through infrared spectroscopy and scanning electron microscopy (SEM), which showed that by compositing with diatomite, new group bridging emerged in the structure of PFS, which made the bond of groups stronger. In addition, part of the metalic contents in diatomite was polymerized with PFS, the product of which was polymerized ferric complex. Furthermore, the absorbing and agglomerating capacity of the diatomite carrier was significant. Considering the factors listed above, the new solid polymerized ferric sulphate (SPFS) flocculant was characterized with a larger molecule structure and enhanced absorbing, bridging and rolling sweep capacities. Through orthogonal experiment, optimum conditions of synthesis were as follows: the ratio of FeSO4.7H2O/diatomite in weight was 43/1, the reaction time is 1 h and the reaction temperature is 55 degrees C. By wastewater treatment experiment, it was found that the synthetic products showed good flocculation performance in the treatment of domestic sewage, the removal of COD was 80.00% and the removal of turbidity was 99.98%.

  7. Pelamis WEC - main body structural design and materials selection

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, C.

    2003-07-01

    This report summarises the results of a study evaluating the potential use of rolled steel, glass reinforced plastic, wood-epoxy laminate, and different forms of concrete as primary structural materials for the Pelamis Wave Energy Converter (WEC) as part of a strategy to refine the design by highlighting cost savings for long-term manufacture. Details are given of the drawing up of a load spectrum in order to assess the candidate structures, the choice of glass reinforced plastic, concrete, and steel for further evaluation based on preliminary screening, the assessment of the material requirements for each candidate structure, and cost estimates. The advantages of the use of concrete are discussed and recommendations are presented.

  8. Earthquake-proof support structures for the recycling pump in FBR type reactors

    International Nuclear Information System (INIS)

    Nakagawa, Masaki; Shigeta, Masayuki.

    1984-01-01

    Purpose: To improve the earthquake proofness of the recycling pump for use in FBR type reactors upon earthquake by reducing the vibration response of the pump. Constitution: The outer casing of a recycle pump suspended into liquid sodium is extended to the portion that penetrates a reactor core support structures. Support structures surrounding the outer side of the recycling pump are disposed with a gap not restraining the free thermal deformations of the recycling pump to the inside of the partition wall structures and the portion of the recycling pump penetrating the reator core support structures, to integrate the support structures with the reactor core support structures. Accordingly, there are no interferences between the recycling pump and the support structures with respect to the thermal deformations that change gradually with time. Upon vibrating under the rapidly changing external forces of earthquakes, however, the pressure resulted to the liquid in the gap due to the vibrations of the recycling pump is transmitted with no escape to the support structures, the recycling pump and the support structures integrally resist the vibrations thereby enabling to reduce the vibrations in the recycling pumps. (Horiuchi, T.)

  9. Decision support system of e-book provider selection for library using Simple Additive Weighting

    Science.gov (United States)

    Ciptayani, P. I.; Dewi, K. C.

    2018-01-01

    Each library has its own criteria and differences in the importance of each criterion in choosing an e-book provider for them. The large number of providers and the different importance levels of each criterion make the problem of determining the e-book provider to be complex and take a considerable time in decision making. The aim of this study was to implement Decision support system (DSS) to assist the library in selecting the best e-book provider based on their preferences. The way of DSS works is by comparing the importance of each criterion and the condition of each alternative decision. SAW is one of DSS method that is quite simple, fast and widely used. This study used 9 criteria and 18 provider to demonstrate how SAW work in this study. With the DSS, then the decision-making time can be shortened and the calculation results can be more accurate than manual calculations.

  10. Alkaline ionic liquids applied in supported ionic liquid catalyst for selective hydrogenation of citral to citronellal

    Directory of Open Access Journals (Sweden)

    Eero eSalminen

    2014-02-01

    Full Text Available The challenge in preparation of ionic liquids containing a strong alkaline anion is to identify a suitable cation which can tolerate the harsh conditions induced by the anion. In this study, a commercial quaternary ammonium compound (quat benzalkonium [ADBA] (alkyldimethylbenzylammonium was used as a cation in the synthesis of different alkaline ionic liquids. In fact, the precursor, benzalkonium chloride, is a mixture of alkyldimethylbenzylammonium chlorides of various alkyl chain lengths and is commonly used in the formulation of various antiseptic products. The prepared ionic liquids were utilized as Supported Ionic Liquid Catalysts (SILCAs. Typically, a SILCA contains metal nanoparticles, enzymes or metal complexes in an ionic liquid layer which is immobilized on a solid carrier material such as an active carbon cloth (ACC. The catalysts were applied in the selective hydrogenation of citral to citronellal which is an important perfumery chemical. Interestingly, 70 % molar yield towards citronellal was achieved over a catalyst containing the alkaline ionic liquid benzalkonium methoxide.

  11. Alkaline ionic liquids applied in supported ionic liquid catalyst for selective hydrogenation of citral to citronellal

    Science.gov (United States)

    Salminen, Eero; Virtanen, Pasi; Mikkola, Jyri-Pekka

    2014-01-01

    The challenge in preparation of ionic liquids containing a strong alkaline anion is to identify a suitable cation which can tolerate the harsh conditions induced by the anion. In this study, a commercial quaternary ammonium compound (quat) benzalkonium [ADBA] (alkyldimethylbenzylammonium) was used as a cation in the synthesis of different alkaline ionic liquids. In fact, the precursor, benzalkonium chloride, is a mixture of alkyldimethylbenzylammonium chlorides of various alkyl chain lengths and is commonly used in the formulation of various antiseptic products. The prepared ionic liquids were utilized as Supported Ionic Liquid Catalysts (SILCAs). Typically, a SILCA contains metal nanoparticles, enzymes, or metal complexes in an ionic liquid layer which is immobilized on a solid carrier material such as an active carbon cloth (ACC). The catalysts were applied in the selective hydrogenation of citral to citronellal which is an important perfumery chemical. Interestingly, 70% molar yield toward citronellal was achieved over a catalyst containing the alkaline ionic liquid benzalkonium methoxide. PMID:24790972

  12. Customer relationship management. Part 3. Selection and implementation. Support of marketing, sales and service contacts

    International Nuclear Information System (INIS)

    Kramer, K.; Van Rheenen, F.; Jonkman, F.

    2000-01-01

    Customer Relationship Management (CRM) is an approach in which differentiated marketing strategies and programmes are developed based on systematically collected information about individual customers. CRM aims at establishing sustainable and profitable customer relationships. The customer information systems presently used in energy companies no longer support the required CRM processes. However, before an organisation decides to buy a new CRM software package, it should first think hard about the strategy it wants to adopt. Does it opt for Operational Excellence, Product Leadership or Customer Intimacy? The company's knowledge about the behaviour of its customers is of major importance especially when the company wants to adopt the Customer Intimacy strategy. Only when the company has established which customer data it has and wants to have, can the right systems be chosen. The selection of a CRM package and its implementation is discussed in this article

  13. Consideration in selecting crops for the human-rated life support system: a Linear Programming model

    Science.gov (United States)

    Wheeler, E. F.; Kossowski, J.; Goto, E.; Langhans, R. W.; White, G.; Albright, L. D.; Wilcox, D.; Henninger, D. L. (Principal Investigator)

    1996-01-01

    A Linear Programming model has been constructed which aids in selecting appropriate crops for CELSS (Controlled Environment Life Support System) food production. A team of Controlled Environment Agriculture (CEA) faculty, staff, graduate students and invited experts representing more than a dozen disciplines, provided a wide range of expertise in developing the model and the crop production program. The model incorporates nutritional content and controlled-environment based production yields of carefully chosen crops into a framework where a crop mix can be constructed to suit the astronauts' needs. The crew's nutritional requirements can be adequately satisfied with only a few crops (assuming vitamin mineral supplements are provided) but this will not be satisfactory from a culinary standpoint. This model is flexible enough that taste and variety driven food choices can be built into the model.

  14. Highly selective formation of imines catalyzed by silver nanoparticles supported on alumina

    DEFF Research Database (Denmark)

    Mielby, Jerrik Jørgen; Poreddy, Raju; Engelbrekt, Christian

    2014-01-01

    The oxidative dehydrogenation of alcohols to aldehydes catalyzed by Ag nanoparticles supported on Al2O3 was studied. The catalyst promoted the direct formation of imines by tandem oxidative dehydrogenation and condensation of alcohols and amines. The reactions were performed under mild conditions......-2 in the gas phase. The use of an efficient and selective Ag catalyst for the oxidative dehydrogenation of alcohol in the presence of amines gives a new green reaction protocol for imine synthesis. (C) 2014, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B...... and afforded the imines in high yield (up to 99%) without any byproducts other than H2O. The highest activity was obtained over 5 wt% Ag/Al2O3 in toluene with air as oxidant. The reactions were also performed under oxidant-free conditions where the reaction was driven to the product side by the production of H...

  15. Decision Support System for Determining Scholarship Selection using an Analytical Hierarchy Process

    Science.gov (United States)

    Puspitasari, T. D.; Sari, E. O.; Destarianto, P.; Riskiawan, H. Y.

    2018-01-01

    Decision Support System is a computer program application that analyzes data and presents it so that users can make decision more easily. Determining Scholarship Selection study case in Senior High School in east Java wasn’t easy. It needed application to solve the problem, to improve the accuracy of targets for prospective beneficiaries of poor students and to speed up the screening process. This research will build system uses the method of Analytical Hierarchy Process (AHP) is a method that solves a complex and unstructured problem into its group, organizes the groups into a hierarchical order, inputs numerical values instead of human perception in comparing relative and ultimately with a synthesis determined elements that have the highest priority. The accuracy system for this research is 90%.

  16. Structural Perspectives of Insulin Receptor Isoform-Selective Insulin Analogs

    Czech Academy of Sciences Publication Activity Database

    Jiráček, Jiří; Žáková, Lenka

    2017-01-01

    Roč. 8, Jul 27 (2017), č. článku 167. ISSN 1664-2392 R&D Projects: GA ČR GA15-19018S Institutional support: RVO:61388963 Keywords : insulin receptor * insulin binding * analog * diabetes * glucose Subject RIV: CE - Biochemistry OBOR OECD: Biochemistry and molecular biology Impact factor: 3.675, year: 2016 http://journal.frontiersin.org/article/10.3389/fendo.2017.00167/full

  17. Structural evaluation report of piping and support structure for design-changed hot-water layer system

    International Nuclear Information System (INIS)

    Ryu, Jeong Soo

    1998-05-01

    After hot-water layer system had been installed, the verification tests to reduce the radiation level at the top of reactor pool were performed many times. The major goal of this report is to assess the structural integrity on the piping and the support structures of design-changed hot-water layer system. The piping stress analysis was performed by using ADLPIPE program for the pump suction line and the pump discharge line subjected to dead weight, pressure, thermal expansion and seismic loadings. The stress analysis of the support structure was carried out using the reaction forces obtained from the piping stress analysis. The results of structural evaluation for the pipings and the support structures showed that the structural acceptance criteria were satisfied, in compliance with ASME, subsection ND for the piping and subsection NF for the support structures. Therefore based on the results of the analysis and the design, the structural integrity on the piping and the support structures of design-changed hot-water system was proved. (author). 9 refs., 9 tabs., 14 figs

  18. Changes in population structures of the major species in selected ...

    African Journals Online (AJOL)

    The study was carried out in six satellite lakes by making investigations on fish collected from experimental and artisanal fisheries. The fishes were analysed for length frequencies, weight and numbers caught to determine the population structure of the fishes. Indiscriminate fishing by deploying illegal gears and increased ...

  19. The influence of phase transfer catalyst structure on reaction selectivity

    International Nuclear Information System (INIS)

    Demlov, Eh.V.

    1995-01-01

    A concise review is given of systematic studies which are concerned with the tuning of regio, frequentio-, chemo-, and diastereoselectivity by the structure or type of phase transfer catalyst. Use of MEI as an alkylating agent is described. Refs. 36, figs. 11

  20. [Age-related characteristics of structural support for ovarian function].

    Science.gov (United States)

    Koval'skiĭ, G B

    1984-12-01

    Histoenzymological assay was used to investigate various structures of the ovaries of rats of two groups aged 3-4 and 12-14 months during estral cycle. The activity of 3 beta-, 17 beta- and 20 alpha-steroid dehydrogenases, glucose-6-phosphate dehydrogenase, NAD and NADP-diaphorases, esterase, acid and alkaline phosphatases was studied. It has been shown that transport alterations in the microcirculation including the hematofollicular barrier play, the leading part in age-dependent depression of reproductive and endocrine functions. Ageing rats demonstrated no linkage between endothelial, thecal and granular cells, which points to the injury of the histophysiological mechanisms of the follicular system integration.

  1. Inclusion of social indicators in decision support tools for the selection of sustainable site remediation options.

    Science.gov (United States)

    Cappuyns, Valérie

    2016-12-15

    Sustainable remediation requires a balanced decision-making process in which environmental, economic and social aspects of different remediation options are all considered together and the optimum remediation solution is selected. More attention has been paid to the evaluation of environmental and economic aspects, in particular to reduce the human and environmental risks and the remediation costs, to the exclusion of social aspects of remediation. This paper investigates how social aspects are currently considered in sustainability assessments of remediation projects. A selection of decision support tools (DSTs), used for the sustainability assessment of a remediation project, is analyzed to define how social aspects are considered in those tools. The social indicator categories of the Sustainable Remediation Forum - United Kingdom (SuRF-UK), are used as a basis for this evaluation. The consideration of social aspects in the investigated decision support tools is limited, but a clear increase is noticed in more recently developed tools. Among the five social indicator categories defined by SuRF-UK to facilitate a holistic consideration of social aspects of a remediation project only "Human health and safety" is systematically taken into account. "Neighbourhood and locality" is also often addressed, mostly emphasizing the potential disturbance caused by the remediation activities. However, the evaluation of 'Ethics and Equality', Communities and community involvement', and 'Uncertainty and evidence' is often neglected. Nevertheless, concrete examples can be found in some of the investigated tools. Specific legislation, standard procedures, and guidelines that have to be followed in a region or country are mainly been set up in the context of protecting human and ecosystem health, safety and prevention of nuisance. However, they sometimes already include some of the aspects addressed by the social indicators. In this perspective the use of DST to evaluate the

  2. A new support structure for high field magnets

    CERN Document Server

    Hafalia, R R; Caspi, S; Dietderich, D R; Gourlay, S A; Hannaford, R; Lietzke, A F; Liggins, N; McInturff, A D; Sabbi, G L; Scanlan, R M; O'Neill, J; Swanson, J H

    2002-01-01

    Pre-stress of superconducting magnets can be applied directly through the magnet yoke structure. We have replaced the collar functionality in our 14 Tesla R&D Nb//3Sn dipole magnets with an assembly procedure based on an aluminum shell and bladders. Bladders, placed between the coil pack and surrounding yoke inside the shell, are pressurized up to 10 ksi left bracket 70 MPa right bracket to create an interference gap. Keys placed into the interference gap replace the bladder functionality. Following the assembly, the bladders are deflated and removed. Strain gauges mounted directly on the shell are used to monitor the stress of the entire magnet structure, thereby providing a high degree of pre-stress control without the need for high tolerances. During assembly, a force of 8.2 multiplied by 10**5 lbs /ft left bracket 12 MN/m right bracket is generated by the bladders and the stress in the 1.57 double prime left bracket 40 mm right bracket aluminum shell reaches 20.3 ksi left bracket 140 MPa right bracket...

  3. Modelling of nuclide migration for support of the site selection for near surface repository in Lithuania

    International Nuclear Information System (INIS)

    Kilda, R.; Poskas, P.; Ragaisis, V.

    2006-01-01

    Construction of the near surface repository (NSR) for disposal of short-lived low-and intermediate-level waste (LILW) is planned in Lithuania. Reference design of the repository was prepared. Site selection process is going on. Environmental Impact Assessment (EIA) Program and Report were prepared and are under review by regulators. Releases of radionuclides to water pathway and potential human exposure after closure of the NSR have been assessed for support of the site selection for NSR installation. Two candidate sites were taken under consideration. The assessments have been performed following ISAM methodology recommended by IAEA for safety assessments of near surface disposal facilities. The conceptual design of NSR as well as peculiarities of geological and hydro-geological environment relevant to each candidate site is taken into account. The results of the analysis as part of EIA Report are presented in the paper. It is demonstrated that estimated impact of potential radionuclide migration for both candidate sites is below dose constrain established by regulations of Lithuania. (author)

  4. Decision Support Model for Selection Technologies in Processing of Palm Oil Industrial Liquid Waste

    Science.gov (United States)

    Ishak, Aulia; Ali, Amir Yazid bin

    2017-12-01

    The palm oil industry continues to grow from year to year. Processing of the palm oil industry into crude palm oil (CPO) and palm kernel oil (PKO). The ratio of the amount of oil produced by both products is 30% of the raw material. This means that 70% is palm oil waste. The amount of palm oil waste will increase in line with the development of the palm oil industry. The amount of waste generated by the palm oil industry if it is not handled properly and effectively will contribute significantly to environmental damage. Industrial activities ranging from raw materials to produce products will disrupt the lives of people around the factory. There are many alternative technologies available to process other industries, but problems that often occur are difficult to implement the most appropriate technology. The purpose of this research is to develop a database of waste processing technology, looking for qualitative and quantitative criteria to select technology and develop Decision Support System (DSS) that can help make decisions. The method used to achieve the objective of this research is to develop a questionnaire to identify waste processing technology and develop the questionnaire to find appropriate database technology. Methods of data analysis performed on the system by using Analytic Hierarchy Process (AHP) and to build the model by using the MySQL Software that can be used as a tool in the evaluation and selection of palm oil mill processing technology.

  5. BLProt: Prediction of bioluminescent proteins based on support vector machine and relieff feature selection

    KAUST Repository

    Kandaswamy, Krishna Kumar

    2011-08-17

    Background: Bioluminescence is a process in which light is emitted by a living organism. Most creatures that emit light are sea creatures, but some insects, plants, fungi etc, also emit light. The biotechnological application of bioluminescence has become routine and is considered essential for many medical and general technological advances. Identification of bioluminescent proteins is more challenging due to their poor similarity in sequence. So far, no specific method has been reported to identify bioluminescent proteins from primary sequence.Results: In this paper, we propose a novel predictive method that uses a Support Vector Machine (SVM) and physicochemical properties to predict bioluminescent proteins. BLProt was trained using a dataset consisting of 300 bioluminescent proteins and 300 non-bioluminescent proteins, and evaluated by an independent set of 141 bioluminescent proteins and 18202 non-bioluminescent proteins. To identify the most prominent features, we carried out feature selection with three different filter approaches, ReliefF, infogain, and mRMR. We selected five different feature subsets by decreasing the number of features, and the performance of each feature subset was evaluated.Conclusion: BLProt achieves 80% accuracy from training (5 fold cross-validations) and 80.06% accuracy from testing. The performance of BLProt was compared with BLAST and HMM. High prediction accuracy and successful prediction of hypothetical proteins suggests that BLProt can be a useful approach to identify bioluminescent proteins from sequence information, irrespective of their sequence similarity. 2011 Kandaswamy et al; licensee BioMed Central Ltd.

  6. Chemiluminescence evidence supporting the selective role of ligands in the permanganate oxidation of micropollutants.

    Science.gov (United States)

    Roderick, Mark S; Adcock, Jacqui L; Terry, Jessica M; Smith, Zoe M; Parry, Samuel; Linton, Stuart M; Thornton, Megan T; Barrow, Colin J; Francis, Paul S

    2013-10-10

    The selective increase in the oxidation rate of certain organic compounds with permanganate in the presence of environmental "ligands" and reduced species has been ascribed to the different reactivity of the target compounds toward Mn(III), which bears striking similarities to recent independent investigations into the use of permanganate as a chemiluminescence reagent. In spite of the importance of Mn(III) in the light-producing pathway, the dependence of the oxidation mechanism for any given compound on this intermediate could not be determined solely through the emission intensity. However, target compounds susceptible to single-electron oxidation by Mn(III) (such as bisphenol A and triclosan) can be easily distinguished by the dramatic increase in chemiluminescence intensity when a permanganate reagent containing high, stable concentrations of Mn(III) is used. The differences are accentuated under the low pH conditions that favor the chemiluminescence emission due to the greater reactivity of Mn(III) and the greater influence of complexing agents. This study supports the previously postulated selective role of ligands and reducing agents in permanganate oxidations and demonstrates a new approach to explore the chemistry of environmental manganese redox processes.

  7. BLProt: Prediction of bioluminescent proteins based on support vector machine and relieff feature selection

    KAUST Repository

    Kandaswamy, Krishna Kumar; Pugalenthi, Ganesan; Hazrati, Mehrnaz Khodam; Kalies, Kai-Uwe; Martinetz, Thomas

    2011-01-01

    Background: Bioluminescence is a process in which light is emitted by a living organism. Most creatures that emit light are sea creatures, but some insects, plants, fungi etc, also emit light. The biotechnological application of bioluminescence has become routine and is considered essential for many medical and general technological advances. Identification of bioluminescent proteins is more challenging due to their poor similarity in sequence. So far, no specific method has been reported to identify bioluminescent proteins from primary sequence.Results: In this paper, we propose a novel predictive method that uses a Support Vector Machine (SVM) and physicochemical properties to predict bioluminescent proteins. BLProt was trained using a dataset consisting of 300 bioluminescent proteins and 300 non-bioluminescent proteins, and evaluated by an independent set of 141 bioluminescent proteins and 18202 non-bioluminescent proteins. To identify the most prominent features, we carried out feature selection with three different filter approaches, ReliefF, infogain, and mRMR. We selected five different feature subsets by decreasing the number of features, and the performance of each feature subset was evaluated.Conclusion: BLProt achieves 80% accuracy from training (5 fold cross-validations) and 80.06% accuracy from testing. The performance of BLProt was compared with BLAST and HMM. High prediction accuracy and successful prediction of hypothetical proteins suggests that BLProt can be a useful approach to identify bioluminescent proteins from sequence information, irrespective of their sequence similarity. 2011 Kandaswamy et al; licensee BioMed Central Ltd.

  8. Allocating structure to function: the strong links between neuroplasticity and natural selection

    Directory of Open Access Journals (Sweden)

    Michael L Anderson

    2014-01-01

    Full Text Available A central question in brain evolution is how species-typical behaviors, and the neural function-structure mappings supporting them, can be acquired and inherited. Advocates of brain modularity, in its different incarnations across scientific subfields, argue that natural selection must target domain-dedicated, separately modifiable neural subsystems, resulting in genetically-specified functional modules. In such modular systems, specification of neuron number and functional connectivity are necessarily linked. Mounting evidence, however, from allometric, developmental, comparative, systems-physiological, neuroimaging and neurological studies suggests that brain elements are used and reused in multiple functional systems. This variable allocation can be seen in short-term neuromodulation, in neuroplasticity over the lifespan and in response to damage. We argue that the same processes are evident in brain evolution. Natural selection must preserve behavioral functions that may co-locate in variable amounts with other functions. In genetics, the uses and problems of pleiotropy, the re-use of genes in multiple networks have been much discussed, but this issue has been sidestepped in neural systems by the invocation of modules. Here we highlight the interaction between evolutionary and developmental mechanisms to produce distributed and overlapping functional architectures in the brain. These adaptive mechanisms must be robust to perturbations that might disrupt critical information processing and action selection, but must also recognize useful new sources of information arising from internal genetic or environmental variability, when those appear. These contrasting properties of robustness and evolvability have been discussed for the basic organization of body plan and fundamental cell physiology. Here we extend them to the evolution and development, evo-devo, of brain structure.

  9. Engineering review of the core support structure of the Gas Cooled Fast Breeder Reactor

    International Nuclear Information System (INIS)

    1978-09-01

    The review of the core support structure of the gas cooled fast breeder reactor (GCFR) covered such areas as the design criteria, the design and analysis of the concepts, the development plan, and the projected manufacturing costs. Recommendations are provided to establish a basis for future work on the GCFR core support structure

  10. Top-down beta rhythms support selective attention via interlaminar interaction: a model.

    Directory of Open Access Journals (Sweden)

    Jung H Lee

    Full Text Available Cortical rhythms have been thought to play crucial roles in our cognitive abilities. Rhythmic activity in the beta frequency band, around 20 Hz, has been reported in recent studies that focused on neural correlates of attention, indicating that top-down beta rhythms, generated in higher cognitive areas and delivered to earlier sensory areas, can support attentional gain modulation. To elucidate functional roles of beta rhythms and underlying mechanisms, we built a computational model of sensory cortical areas. Our simulation results show that top-down beta rhythms can activate ascending synaptic projections from L5 to L4 and L2/3, responsible for biased competition in superficial layers. In the simulation, slow-inhibitory interneurons are shown to resonate to the 20 Hz input and modulate the activity in superficial layers in an attention-related manner. The predicted critical roles of these cells in attentional gain provide a potential mechanism by which cholinergic drive can support selective attention.

  11. Which species? A decision-support tool to guide plant selection in stormwater biofilters

    Science.gov (United States)

    Payne, Emily G. I.; Pham, Tracey; Deletic, Ana; Hatt, Belinda E.; Cook, Perran L. M.; Fletcher, Tim D.

    2018-03-01

    Plant species are diverse in form, function and environmental response. This provides enormous potential for designing nature-based stormwater treatment technologies, such as biofiltration systems. However, species can vary dramatically in their pollutant-removal performance, particularly for nitrogen removal. Currently, there is a lack of information on how to efficiently select from the vast palette of species. This study aimed to identify plant traits beneficial to performance and create a decision-support tool to screen species for further testing. A laboratory experiment using 220 biofilter columns paired plant morphological characteristics with nitrogen removal and water loss for 20 Australian native species and two lawn grasses. Testing was undertaken during wet and dry conditions, for two biofilter designs (saturated zone and free-draining). An extensive root system and high total biomass were critical to the effective removal of total nitrogen (TN) and nitrate (NO3-), driven by high nitrogen assimilation. The same characteristics were key to performance under dry conditions, and were associated with high water use for Australian native plants; linking assimilation and transpiration. The decision-support tool uses these scientific relationships and readily-available information to identify the morphology, natural distribution and stress tolerances likely to be good predictors of plant nitrogen and water uptake.

  12. Plate-impact loading of cellular structures formed by selective laser melting

    International Nuclear Information System (INIS)

    Winter, R E; Cotton, M; Harris, E J; Maw, J R; Chapman, D J; Eakins, D E; McShane, G

    2014-01-01

    Porous materials are of great interest because of improved energy absorption over their solid counterparts. Their properties, however, have been difficult to optimize. Additive manufacturing has emerged as a potential technique to closely define the structure and properties of porous components, i.e. density, strut width and pore size; however, the behaviour of these materials at very high impact energies remains largely unexplored. We describe an initial study of the dynamic compression response of lattice materials fabricated through additive manufacturing. Lattices consisting of an array of intersecting stainless steel rods were fabricated into discs using selective laser melting. The resulting discs were impacted against solid stainless steel targets at velocities ranging from 300 to 700 m s −1 using a gas gun. Continuum CTH simulations were performed to identify key features in the measured wave profiles, while 3D simulations, in which the individual cells were modelled, revealed details of microscale deformation during collapse of the lattice structure. The validated computer models have been used to provide an understanding of the deformation processes in the cellular samples. The study supports the optimization of cellular structures for application as energy absorbers. (paper)

  13. Perivascular adipose tissue: more than just structural support.

    Science.gov (United States)

    Szasz, Theodora; Webb, R Clinton

    2012-01-01

    PVAT (perivascular adipose tissue) has recently been recognized as a novel factor in vascular biology, with implications in the pathophysiology of cardiovascular disease. Composed mainly of adipocytes, PVAT releases a wide range of biologically active molecules that modulate vascular smooth muscle cell contraction, proliferation and migration. PVAT exerts an anti-contractile effect in various vascular beds which seems to be mediated by an as yet elusive PVRF [PVAT-derived relaxing factor(s)]. Considerable progress has been made on deciphering the nature and mechanisms of action of PVRF, and the PVRFs proposed until now are reviewed here. However, complex pathways seem to regulate PVAT function and more than one mechanism is probably responsible for PVAT actions in vascular biology. The present review describes our current knowledge on the structure and function of PVAT, with a focus on its role in modulating vascular tone. Potential involvements of PVAT dysfunction in obesity, hypertension and atherosclerosis will be highlighted.

  14. Filtered selection coupled with support vector machines generate a functionally relevant prediction model for colorectal cancer

    Directory of Open Access Journals (Sweden)

    Gabere MN

    2016-06-01

    Full Text Available Musa Nur Gabere,1 Mohamed Aly Hussein,1 Mohammad Azhar Aziz2 1Department of Bioinformatics, King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 2Colorectal Cancer Research Program, Department of Medical Genomics, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia Purpose: There has been considerable interest in using whole-genome expression profiles for the classification of colorectal cancer (CRC. The selection of important features is a crucial step before training a classifier.Methods: In this study, we built a model that uses support vector machine (SVM to classify cancer and normal samples using Affymetrix exon microarray data obtained from 90 samples of 48 patients diagnosed with CRC. From the 22,011 genes, we selected the 20, 30, 50, 100, 200, 300, and 500 genes most relevant to CRC using the minimum-redundancy–maximum-relevance (mRMR technique. With these gene sets, an SVM model was designed using four different kernel types (linear, polynomial, radial basis function [RBF], and sigmoid.Results: The best model, which used 30 genes and RBF kernel, outperformed other combinations; it had an accuracy of 84% for both ten fold and leave-one-out cross validations in discriminating the cancer samples from the normal samples. With this 30 genes set from mRMR, six classifiers were trained using random forest (RF, Bayes net (BN, multilayer perceptron (MLP, naïve Bayes (NB, reduced error pruning tree (REPT, and SVM. Two hybrids, mRMR + SVM and mRMR + BN, were the best models when tested on other datasets, and they achieved a prediction accuracy of 95.27% and 91.99%, respectively, compared to other mRMR hybrid models (mRMR + RF, mRMR + NB, mRMR + REPT, and mRMR + MLP. Ingenuity pathway analysis was used to analyze the functions of the 30 genes selected for this model and their potential association with CRC: CDH3, CEACAM7, CLDN1, IL8, IL6R, MMP1

  15. Artificial neural network models: A decision support tool for enhancing seedling selection in sugarcane

    Science.gov (United States)

    Currently, sugarcane selection begins at the seedling stage with visual selection for cane yield and other yield-related traits. Although subjective and inefficient, visual selection remains the primary method for selection. Visual selection is inefficient because of the confounding effect of genoty...

  16. Microstructural and mineralogical characterization of selected shales in support of nuclear waste repository studies

    International Nuclear Information System (INIS)

    Lee, S.Y.; Hyder, L.K.; Alley, P.D.

    1988-01-01

    Five shales were examined as part of the Sedimentary Rock Program evaluation of this medium as a potential host for a US civilian nuclear waste repository. The units selected for characterization were the Chattanooga Shale from Fentress County, Tennessee; the Pierre Shale from Gregory County, South Dakota; the Green River Formation from Garfield County, Colorado; and the Nolichucky Shale and Pumpkin Valley Shale from Roane County, Tennessee. The micromorphology and structure of the shales were examined by petrographic, scanning electron, and high-resolution transmission electron microscopy. Chemical and mineralogical compositions were studied through the use of energy-dispersive x-ray, neutron activation, atomic absorption, thermal, and x-ray diffraction analysis techniques. 18 refs., 12 figs., 2 tabs

  17. WikiD : A WikiEngine Supporting Structured Data

    CERN Multimedia

    CERN. Geneva; Young, Jeffrey

    2005-01-01

    Ward Cunningham describes a wiki as "the simplest online database that could possibly work". The cost of this simplicity is that wikis are generally limited to a single collection containing a single kind of record (viz. WikiMarkupLanguage records). WikiD extends the Wiki model to support multiple collections containing arbitrary schemas of XML records with minimal additional complexity. WikiD is essentially a lightweight framework combining: * Open-source implementations of various loosely-coupled open-standard protocols (e.g. OpenURL, SRW/U, SRW Update, OAI-PMH, RSS) * An open-source version-controlled database. * A set of bootstrap collections. * XSL Stylesheets to render collection-level open-standard protocol responses into HTML for human consumption. Automated processes can ignore the stylesheet reference and use the open-standard protocol responses directly. Possible applications for WikiD include collaborative maintenance of registries, thesauri, taxonomies, reviews, and documentation. In addition to ...

  18. Figure-ground mechanisms provide structure for selective attention.

    Science.gov (United States)

    Qiu, Fangtu T; Sugihara, Tadashi; von der Heydt, Rüdiger

    2007-11-01

    Attention depends on figure-ground organization: figures draw attention, whereas shapes of the ground tend to be ignored. Recent research has revealed mechanisms for figure-ground organization in the visual cortex, but how these mechanisms relate to the attention process remains unclear. Here we show that the influences of figure-ground organization and volitional (top-down) attention converge in single neurons of area V2 in Macaca mulatta. Although we found assignment of border ownership for attended and for ignored figures, attentional modulation was stronger when the attended figure was located on the neuron's preferred side of border ownership. When the border between two overlapping figures was placed in the receptive field, responses depended on the side of attention, and enhancement was generally found on the neuron's preferred side of border ownership. This correlation suggests that the neural network that creates figure-ground organization also provides the interface for the top-down selection process.

  19. Intragranular cellular segregation network structure strengthening 316L stainless steel prepared by selective laser melting

    Energy Technology Data Exchange (ETDEWEB)

    Zhong, Yuan; Liu, Leifeng [Department of Materials and Environmental Chemistry, Arrhenius Laboratory, Stockholm University, 10691 Stockholm (Sweden); Wikman, Stefan [Fusion for Energy, Torres Diagonal Litoral B3, Josep Pla 2, 08019 Barcelona (Spain); Cui, Daqing [Department of Materials and Environmental Chemistry, Arrhenius Laboratory, Stockholm University, 10691 Stockholm (Sweden); Shen, Zhijian, E-mail: shen@mmk.su.se [Department of Materials and Environmental Chemistry, Arrhenius Laboratory, Stockholm University, 10691 Stockholm (Sweden)

    2016-03-15

    A feasibility study was performed to fabricate ITER In-Vessel components by Selective Laser Melting (SLM) supported by Fusion for Energy (F4E). Almost fully dense 316L stainless steel (SS316L) components were prepared from gas-atomized powder and with optimized SLM processing parameters. Tensile tests and Charpy-V tests were carried out at 22 °C and 250 °C and the results showed that SLM SS316L fulfill the RCC-MR code. Microstructure characterization reveals the presence of hierarchical macro-, micro- and nano-structures in as-built samples that were very different from SS316L microstructures prepared by other established methods. The formation of a characteristic intragranular cellular segregation network microstructure appears to contribute to the increase of yield strength without losing ductility. Silicon oxide nano-inclusions were formed during the SLM process that generated a micro-hardness fluctuation in the building direction. The combined influence of a cellular microstructure and the nano-inclusions constraints the size of ductile dimples to nano-scale. The crack propagation is hindered by a pinning effect that improves the defect-tolerance of the SLM SS316L. This work proves that it was possible to manufacture SS316L with properties suitable for ITER First Wall panels. Further studies on irradiation properties of SLM SS316L and manufacturing of larger real-size components are needed. - Highlights: • The mechanical properties of SS316L made by selective laser melting fulfill RCC-MR. • SLM SS316L consists hierarchical structures of high heterogeneity. • Silicon rich oxide nano-inclusions are formed unexpectedly during SLM process. • Cellular structure and oxide nano-inclusions strengthen SLM SS316L.

  20. Reliability of ultrasound for measurement of selected foot structures.

    Science.gov (United States)

    Crofts, G; Angin, S; Mickle, K J; Hill, S; Nester, C J

    2014-01-01

    Understanding the relationship between the lower leg muscles, foot structures and function is essential to explain how disease or injury may relate to changes in foot function and clinical pathology. The aim of this study was to investigate the inter-operator reliability of an ultrasound protocol to quantify features of: rear, mid and forefoot sections of the plantar fascia (PF); flexor hallucis brevis (FHB); flexor digitorum brevis (FDB); abductor hallucis (AbH); flexor digitorum longus (FDL); flexor hallucis longus (FHL); tibialis anterior (TA); and peroneus longus and brevis (PER). A sample of 6 females and 4 males (mean age 29.1 ± 7.2 years, mean BMI 25.5 ± 4.8) was recruited from a university student and staff population. Scans were obtained using a portable Venue 40 musculoskeletal ultrasound system (GE Healthcare UK) with a 5-13 MHz wideband linear array probe with a 12.7 mm × 47.1mm footprint by two operators in the same scanning session. Intraclass Correlation Coefficients (ICC) values for muscle thickness (ICC range 0.90-0.97), plantar fascia thickness (ICC range 0.94-0.98) and cross sectional muscle measurements (ICC range 0.91-0.98) revealed excellent inter-operator reliability. The limits of agreement, relative to structure size, ranged from 9.0% to 17.5% for muscle thickness, 11.0-18.0% for plantar fascia, and 11.0-26.0% for cross sectional area measurements. The ultrasound protocol implemented in this work has been shown to be reliable. It therefore offers the opportunity to quantify the structures concerned and better understand their contributions to foot function. Crown Copyright © 2013. Published by Elsevier B.V. All rights reserved.

  1. Selected Aspects of Computer Modeling of Reinforced Concrete Structures

    Directory of Open Access Journals (Sweden)

    Szczecina M.

    2016-03-01

    Full Text Available The paper presents some important aspects concerning material constants of concrete and stages of modeling of reinforced concrete structures. The problems taken into account are: a choice of proper material model for concrete, establishing of compressive and tensile behavior of concrete and establishing the values of dilation angle, fracture energy and relaxation time for concrete. Proper values of material constants are fixed in simple compression and tension tests. The effectiveness and correctness of applied model is checked on the example of reinforced concrete frame corners under opening bending moment. Calculations are performed in Abaqus software using Concrete Damaged Plasticity model of concrete.

  2. Coexistence of structured populations with size-based prey selection

    DEFF Research Database (Denmark)

    Hartvig, Martin; Andersen, Ken Haste

    2013-01-01

    Abstract Species with a large adult-offspring size ratio and a preferred predator–prey mass ratio undergo ontogenetic trophic niche shift(s) throughout life. Trophic interactions between such species vary throughout life, resulting in different species-level interaction motifs depending on the ma......Abstract Species with a large adult-offspring size ratio and a preferred predator–prey mass ratio undergo ontogenetic trophic niche shift(s) throughout life. Trophic interactions between such species vary throughout life, resulting in different species-level interaction motifs depending...... on the maximum adult sizes and population size distributions. We explore the assembly and potential for coexistence of small communities where all species experience ontogenetic trophic niche shifts. The life-history of each species is described by a physiologically structured model and species identity...... there is a large scope for coexistence of two species, the scope for coexistence of three species is limited and we conclude that further trait differentiation is required for coexistence of more species-rich size-structured communities....

  3. [Incentive for Regional Risk Selection in the German Risk Structure Compensation Scheme].

    Science.gov (United States)

    Wende, Danny

    2017-10-01

    The introduction of the new law GKV-FQWG strengthens the competition between statutory health insurance. If incentives for risk selection exist, they may force a battle for cheap customers. This study aims to document and discuss incentives for regional risk selection in the German risk structure compensation scheme. Identify regional autocorrelation with Moran's l on financial parameters of the risk structure compensation schema. Incentives for regional risk selection do indeed exist. The risk structure compensation schema reduces 91% of the effect and helps to reduce risk selection. Nevertheless, a connection between regional situation and competition could be shown (correlation: 69.5%). Only the integration of regional control variables into the risk compensation eliminates regional autocorrelation. The actual risk structure compensation is leading to regional inequalities and as a consequence to risk selection and distortion in competition. © Georg Thieme Verlag KG Stuttgart · New York.

  4. Selected Aspects of Agro-structural Change within the Alps

    Directory of Open Access Journals (Sweden)

    Thomas Streifeneder

    2009-07-01

    Full Text Available La région couverte par la Convention alpine a connu un recul important des exploitations agricoles (– 40 % entre 1980 et 2000. Des régions stables (Autriche, Suisse côtoient des régions profondément transformées (Italie, Slovénie. Les modifications agrostructurelles ont conduit à des bouleversements majeurs dans les structures de fonctionnement (agrandissement des exploitations, abandon de surface agricole utile, partages diversifiés des types socio-économiques d’exploitations. Cela résulte de divers facteurs, qu’ils soient culturels (l’attachement aux traditions agricoles, l’identification de la société au monde agricole, politico-agricoles (Politique Agricole Commune, OMC ou économiques (opportunités de revenus non-agricoles et fonctionnels (taille des exploitations. Au-delà des différenciations nationales et régionales majeures au sein de l’arc alpin (abandon d’exploitations modéré à fort, les exploitations agricoles affrontent les mêmes enjeux en ce qui concerne les transformations des structures agricoles (ex : abandon d’exploitation et augmentation de la taille des exploitations restantes. En comparaison avec la moyenne à l’échelle alpine de l’évolution du nombre d’exploitations et des surfaces agricoles utiles (1980-2000, on peut observer des tendances modérées (Autriche/Suisse/Allemagne, dynamiques (Italie/Slovénie ou non corrélées (France.The Alpine region registered a substantial abandonment of farms (-40% between 1980 and 2000. Both Alpine regions with a relatively stable situation (AT, CH and regions with significant agricultural changes (IT, SI exist next to each other. The agro-structural change has led to profound changes in operational structures (enlargement of farms, abandonment of utilised agricultural areas, varying shares of socio-economic farm types. This resulted from various cultural (e.g. relatedness to agricultural traditions, identification of the society with

  5. Additive Manufacturing of Overhang Structures Using Moisture-Cured Silicone with Support Material

    Directory of Open Access Journals (Sweden)

    Mohan Muthusamy

    2018-04-01

    Full Text Available Additive manufacturing (AM of soft materials has a wide variety of applications, such as customized or wearable devices. Silicone is one popular material for these applications given its favorable material properties. However, AM of silicone parts with overhang structures remains challenging due to the soft nature of the material. Overhang structures are the areas where there is no underlying structure. Typically, a support material is used and built in the underlying space so that the overhang structures can be built upon it. Currently, there is no support structure that has been used for AM of silicone. The goal of this study is to develop an AM process to fabricate silicone parts with overhang structures. We first identified and confirmed poly-vinyl alcohol (PVA, a water-soluble material, as a suitable support material for silicone by evaluating the adhesion strength between silicone and PVA. Process parameters for the support material, including critical overhang angle and minimum infill density for the support material, are identified. However, overhang angle alone is not the only determining factor for support material. As silicone is a soft material, it deflects due to its own weight when the height of the overhang structure increases. A finite element model is developed to estimate the critical overhang height paired with different overhang angles to determine whether the use of support material is needed. Finally, parts with overhang structures are printed to demonstrate the capability of the developed process.

  6. Structural assessments of plate type support system for APR1400 reactor

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Anh Tung; Namgung, Ihn, E-mail: inamgung@kings.ac.kr

    2017-04-01

    Highlights: • This paper investigates plate-type support structure for the reactor vessel of the APR 1400. • The tall column supports of APR1400 reactor challenges in seismic and severe accident events. • A plate-type support of reactor vessel was proposed and evaluated based on ASME code. • The plate-type support was assessed to show its higher rigidity than column-type. - Abstract: This paper investigates an alternative form of support structure for the reactor vessel of the APR 1400. The current reactor vessel adopts a four-column support arrangement locating on the cold legs of the vessel. Although having been successfully designed, the tall column structure challenges in seismic events. In addition, for the mitigation of severe accident consequences, the columns inhibit ex-vessel coolant flow, hence the elimination of the support columns proposes extra safety advantages. A plate-type support was proposed and evaluated for the adequacy of meeting the structural stiffness by Finite Element Analysis (FEA) approach. ASME Boiler and Pressure Vessel Code was used to verify the design. The results, which cover thermal and static structural analysis, show stresses are within allowable limits in accordance with the design code. Even the heat conduction area is increased for the plate-type of support system, the results showed that the thermal stresses are within allowable limits. A comparison of natural frequencies and mode shapes for column support and plate-type support were presented as well which showed higher fundamental frequencies for the plate-type support system resulting in greater rigidity of the support system. From the outcome of this research, the plate-type support is proven to be an alternative to current APR column type support design.

  7. Final Report: Evaluation of Tools and Metrics to Support Employer Selection of Health Plans.

    Science.gov (United States)

    Mattke, Soeren; Van Busum, Kristin R; Martsolf, Grant R

    2014-01-01

    The Patient Protection and Affordable Care Act (ACA) places strong emphasis on quality of care as a means to improve outcomes for Americans and promote the financial sustainability of our health care system. Included in the ACA are new disclosure requirements that require health plans to provide a summary of benefits and coverage that accurately describes the benefits under the plan or coverage. These requirements are intended to support employers' procurement of high-value health coverage for their employees. This study attempts to help employers understand the structural differences between health plans and the performance dimensions along which plans can differ, as well as to educate employers about available tools that can be used to evaluate plan options. The study also discusses the extent to which these and other tools or resources are used by employers to inform choices between health plans.

  8. Sol-gel synthesis of iron catalysers supported on silica and titanium for selectively oxidising methane to formaldehyde

    OpenAIRE

    Carlos Alberto Guerrero Fajardo; Francisco José Sánchez Castellanos; Anne Cécile Roger; Claire Courson

    2010-01-01

    Iron materials supported on silica were prepared by the sol-gel method for evaluating catalytic activity in selective o-xidation of methane to formaldehyde. Four catalysts were prepared, one corresponding to the silica support (catalyst 1S), another to the titanium support (catalyst 1T) and two more having 0.5% weight iron loads, one for the silica su-pport (catalyst 2FS) and the last one the titanium support (catalyst 2FT). The higher BET areas were 659 and 850 m2/g for catalysts 1S and 2FS,...

  9. Selective visualization of gene structure with ultraviolet light

    International Nuclear Information System (INIS)

    Wang, Z.; Becker, M.M.

    1988-01-01

    The ability of the ultraviolet (UV) footprinting technique to detect chromatin has been investigated in vitro. Two basic types of chromatin, a phased nucleosome and a phased nucleosome containing a phased H1 protein, have been reconstituted onto a cloned 5S ribosomal RNA gene from sea urchin. The histone-DNA interactions in each complex have been probed with exonuclease III, DNase I, dimethyl sulfate, and UV light. Whereas DNase I and exonuclease III readily detect interactions between histones and DNA, UV light and dimethyl sulfate do not. In contrast to histone-DNA interactions, we demonstrate that intimate sequence-specific contacts between the same sea urchin 5S DNA and the Xenopus laevis transcription factor IIIA (TFIIIA) are readily detected with UV light. Since the sensitivity of UV light for TFIIIA contacts is similar to its sensitivity for other regulatory protein-DNA contacts, these studies demonstrate the feasibility of using UV light to selectively visualize regulatory protein-DNA interactions in vivo with little or no interference from histone-DNA interactions

  10. Forecast of hourly global horizontal irradiance based on structured Kernel Support Vector Machine: A case study of Tibet area in China

    International Nuclear Information System (INIS)

    Jiang, He; Dong, Yao

    2017-01-01

    Highlights: • The structured variable selection in Kernel SVM is implemented using two ways. • The two-way interaction model is considered to enforce Heredity Principle. • SVMIC is used to select the kernel parameter in proposed approaches. • Simple and fast computations algorithms are derived. - Abstract: Various applications of forecasting effective global horizontal irradiance play increasingly vital role in grid-connected photovoltaic installations, but suffer from forecasting inaccuracy and prohibitively expensive computational cost. Although Support Vector Machine (SVM) is one of the most powerful forecasting approaches, it does not provide an interpretable model. This motivates penalized variable selection methods to be introduced to SVM to select important variables. However, in some forecasting problems, there are some underlying logic or hierarchical structure such as heredity principle among the variables. Penalized Kernel SVM approaches do not take heredity principles into consideration when enforcing sparsity. This paper investigates structural variable selection in Kernel SVM based approach which pursues heredity principle and sparsity simultaneously. To achieve heredity principle, both optimization and procedure based structural variable selection approaches are studied in the Kernel SVM. Computationally, we derive fast and simple-to-implement algorithms to perform structural variable selection and solar irradiance forecasting. Furthermore, Support Vector Machines Information Criterion is utilized to select the kernel parameters to guarantee the model consistency. Real data experiments directly reveal that our proposed KSVM-SVS based approach following heredity principle delivers superior performances in terms of forecasting accuracy comparing with other competitors.

  11. Considering Future Potential Regarding Structural Diversity in Selection of Forest Reserves.

    Directory of Open Access Journals (Sweden)

    Johanna Lundström

    Full Text Available A rich structural diversity in forests promotes biodiversity. Forests are dynamic and therefore it is crucial to consider future structural potential when selecting reserves, to make robust conservation decisions. We analyzed forests in boreal Sweden based on 17,599 National Forest Inventory (NFI plots with the main aim to understand how effectiveness of reserves depends on the time dimension in the selection process, specifically by considering future structural diversity. In the study both the economic value and future values of 15 structural variables were simulated during a 100 year period. To get a net present structural value (NPSV, a single value covering both current and future values, we used four discounting alternatives: (1 only considering present values, (2 giving equal importance to values in each of the 100 years within the planning horizon, (3 applying an annual discount rate considering the risk that values could be lost, and (4 only considering the values in year 100. The four alternatives were evaluated in a reserve selection model under budget-constrained and area-constrained selections. When selecting young forests higher structural richness could be reached at a quarter of the cost over almost twice the area in a budget-constrained selection compared to an area-constrained selection. Our results point to the importance of considering future structural diversity in the selection of forest reserves and not as is done currently to base the selection on existing values. Targeting future values increases structural diversity and implies a relatively lower cost. Further, our results show that a re-orientation from old to young forests would imply savings while offering a more extensive reserve network with high structural qualities in the future. However, caution must be raised against a drastic reorientation of the current old-forest strategy since remnants of ancient forests will need to be prioritized due to their role for

  12. Classification of Alzheimer's disease patients with hippocampal shape wrapper-based feature selection and support vector machine

    Science.gov (United States)

    Young, Jonathan; Ridgway, Gerard; Leung, Kelvin; Ourselin, Sebastien

    2012-02-01

    It is well known that hippocampal atrophy is a marker of the onset of Alzheimer's disease (AD) and as a result hippocampal volumetry has been used in a number of studies to provide early diagnosis of AD and predict conversion of mild cognitive impairment patients to AD. However, rates of atrophy are not uniform across the hippocampus making shape analysis a potentially more accurate biomarker. This study studies the hippocampi from 226 healthy controls, 148 AD patients and 330 MCI patients obtained from T1 weighted structural MRI images from the ADNI database. The hippocampi are anatomically segmented using the MAPS multi-atlas segmentation method, and the resulting binary images are then processed with SPHARM software to decompose their shapes as a weighted sum of spherical harmonic basis functions. The resulting parameterizations are then used as feature vectors in Support Vector Machine (SVM) classification. A wrapper based feature selection method was used as this considers the utility of features in discriminating classes in combination, fully exploiting the multivariate nature of the data and optimizing the selected set of features for the type of classifier that is used. The leave-one-out cross validated accuracy obtained on training data is 88.6% for classifying AD vs controls and 74% for classifying MCI-converters vs MCI-stable with very compact feature sets, showing that this is a highly promising method. There is currently a considerable fall in accuracy on unseen data indicating that the feature selection is sensitive to the data used, however feature ensemble methods may overcome this.

  13. Structure-based prediction of subtype selectivity of histamine H3 receptor selective antagonists in clinical trials.

    Science.gov (United States)

    Kim, Soo-Kyung; Fristrup, Peter; Abrol, Ravinder; Goddard, William A

    2011-12-27

    Histamine receptors (HRs) are excellent drug targets for the treatment of diseases, such as schizophrenia, psychosis, depression, migraine, allergies, asthma, ulcers, and hypertension. Among them, the human H(3) histamine receptor (hH(3)HR) antagonists have been proposed for specific therapeutic applications, including treatment of Alzheimer's disease, attention deficit hyperactivity disorder (ADHD), epilepsy, and obesity. However, many of these drug candidates cause undesired side effects through the cross-reactivity with other histamine receptor subtypes. In order to develop improved selectivity and activity for such treatments, it would be useful to have the three-dimensional structures for all four HRs. We report here the predicted structures of four HR subtypes (H(1), H(2), H(3), and H(4)) using the GEnSeMBLE (GPCR ensemble of structures in membrane bilayer environment) Monte Carlo protocol, sampling ∼35 million combinations of helix packings to predict the 10 most stable packings for each of the four subtypes. Then we used these 10 best protein structures with the DarwinDock Monte Carlo protocol to sample ∼50 000 × 10(20) poses to predict the optimum ligand-protein structures for various agonists and antagonists. We find that E206(5.46) contributes most in binding H(3) selective agonists (5, 6, 7) in agreement with experimental mutation studies. We also find that conserved E5.46/S5.43 in both of hH(3)HR and hH(4)HR are involved in H(3)/ H(4) subtype selectivity. In addition, we find that M378(6.55) in hH(3)HR provides additional hydrophobic interactions different from hH(4)HR (the corresponding amino acid of T323(6.55) in hH(4)HR) to provide additional subtype bias. From these studies, we developed a pharmacophore model based on our predictions for known hH(3)HR selective antagonists in clinical study [ABT-239 1, GSK-189,254 2, PF-3654746 3, and BF2.649 (tiprolisant) 4] that suggests critical selectivity directing elements are: the basic proton

  14. Diel habitat selection of largemouth bass following woody structure installation in Table Rock Lake, Missouri

    Science.gov (United States)

    Harris, J.M.; Paukert, Craig P.; Bush, S.C.; Allen, M.J.; Siepker, Michael

    2018-01-01

    Largemouth bass Micropterus salmoides (Lacepède) use of installed habitat structure was evaluated in a large Midwestern USA reservoir to determine whether or not these structures were used in similar proportion to natural habitats. Seventy largemouth bass (>380 mm total length) were surgically implanted with radio transmitters and a subset was relocated monthly during day and night for one year. The top habitat selection models (based on Akaike's information criterion) suggest largemouth bass select 2–4 m depths during night and 4–7 m during day, whereas littoral structure selection was similar across diel periods. Largemouth bass selected boat docks at twice the rate of other structures. Installed woody structure was selected at similar rates to naturally occurring complex woody structure, whereas both were selected at a higher rate than simple woody structure. The results suggest the addition of woody structure may concentrate largemouth bass and mitigate the loss of woody habitat in a large reservoir.

  15. Do brain image databanks support understanding of normal ageing brain structure? A systematic review

    International Nuclear Information System (INIS)

    Dickie, David Alexander; Job, Dominic E.; Wardlaw, Joanna M.; Poole, Ian; Ahearn, Trevor S.; Staff, Roger T.; Murray, Alison D.

    2012-01-01

    To document accessible magnetic resonance (MR) brain images, metadata and statistical results from normal older subjects that may be used to improve diagnoses of dementia. We systematically reviewed published brain image databanks (print literature and Internet) concerned with normal ageing brain structure. From nine eligible databanks, there appeared to be 944 normal subjects aged ≥60 years. However, many subjects were in more than one databank and not all were fully representative of normal ageing clinical characteristics. Therefore, there were approximately 343 subjects aged ≥60 years with metadata representative of normal ageing, but only 98 subjects were openly accessible. No databank had the range of MR image sequences, e.g. T2*, fluid-attenuated inversion recovery (FLAIR), required to effectively characterise the features of brain ageing. No databank supported random subject retrieval; therefore, manual selection bias and errors may occur in studies that use these subjects as controls. Finally, no databank stored results from statistical analyses of its brain image and metadata that may be validated with analyses of further data. Brain image databanks require open access, more subjects, metadata, MR image sequences, searchability and statistical results to improve understanding of normal ageing brain structure and diagnoses of dementia. (orig.)

  16. Characterization of structure and function of ZS-9, a K+ selective ion trap.

    Directory of Open Access Journals (Sweden)

    Fiona Stavros

    Full Text Available Hyperkalemia, a condition in which serum potassium ions (K+ exceed 5.0 mmol/L, is a common electrolyte disorder associated with substantial morbidity. Current methods of managing hyperkalemia, including organic polymer resins such as sodium polystyrene sulfonate (SPS, are poorly tolerated and/or not effective. Sodium zirconium cyclosilicate (ZS-9 is under clinical development as an orally administered, non-absorbed, novel, inorganic microporous zirconium silicate compound that selectively removes excess K+ in vivo. The development, structure and ion exchange properties of ZS-9 and its hypothesized mechanism of action are described. Based on calculation of the interatomic distances between the atoms forming the ZS-9 micropores, the size of the pore opening was determined to be ∼ 3 Å (∼ diameter of unhydrated K+. Unlike nonspecific organic polymer resins like SPS, the ZS-9 K+ exchange capacity (KEC was unaffected by the presence of calcium (Ca2+ or magnesium ions (Mg2+ and showed>25-fold selectivity for K+ over either Ca2+ or Mg2+. Conversely, the selectivity of SPS for K+ was only 0.2-0.3 times its selectivity for Ca2+ or Mg2+in mixed ionic media. It is hypothesized that the high K+ specificity of ZS-9 is attributable to the chemical composition and diameter of the micropores, which possibly act in an analogous manner to the selectivity filter utilized by physiologic K+ channels. This hypothesized mechanism of action is supported by the multi-ion exchange studies. The effect of pH on the KEC of ZS-9 was tested in different media buffered to mimic different portions of the human gastrointestinal tract. Rapid K+ uptake was observed within 5 minutes - mainly in the simulated small intestinal and large intestinal fluids, an effect that was sustained for up to 1 hour. If approved, ZS-9 will represent a novel, first-in-class therapy for hyperkalemia with improved capacity, selectivity, and speed for entrapping K+ when compared to currently

  17. Decision support for the selection of reference sites using 137Cs as a soil erosion tracer

    Directory of Open Access Journals (Sweden)

    L. Arata

    2017-08-01

    Full Text Available The classical approach of using 137Cs as a soil erosion tracer is based on the comparison between stable reference sites and sites affected by soil redistribution processes; it enables the derivation of soil erosion and deposition rates. The method is associated with potentially large sources of uncertainty with major parts of this uncertainty being associated with the selection of the reference sites. We propose a decision support tool to Check the Suitability of reference Sites (CheSS. Commonly, the variation among 137Cs inventories of spatial replicate reference samples is taken as the sole criterion to decide on the suitability of a reference inventory. Here we propose an extension of this procedure using a repeated sampling approach, in which the reference sites are resampled after a certain time period. Suitable reference sites are expected to present no significant temporal variation in their decay-corrected 137Cs depth profiles. Possible causes of variation are assessed by a decision tree. More specifically, the decision tree tests for (i uncertainty connected to small-scale variability in 137Cs due to its heterogeneous initial fallout (such as in areas affected by the Chernobyl fallout, (ii signs of erosion or deposition processes and (iii artefacts due to the collection, preparation and measurement of the samples; (iv finally, if none of the above can be assigned, this variation might be attributed to turbation processes (e.g. bioturbation, cryoturbation and mechanical turbation, such as avalanches or rockfalls. CheSS was exemplarily applied in one Swiss alpine valley where the apparent temporal variability called into question the suitability of the selected reference sites. In general we suggest the application of CheSS as a first step towards a comprehensible approach to test for the suitability of reference sites.

  18. Investigating energy-based pool structure selection in the structure ensemble modeling with experimental distance constraints: The example from a multidomain protein Pub1.

    Science.gov (United States)

    Zhu, Guanhua; Liu, Wei; Bao, Chenglong; Tong, Dudu; Ji, Hui; Shen, Zuowei; Yang, Daiwen; Lu, Lanyuan

    2018-05-01

    The structural variations of multidomain proteins with flexible parts mediate many biological processes, and a structure ensemble can be determined by selecting a weighted combination of representative structures from a simulated structure pool, producing the best fit to experimental constraints such as interatomic distance. In this study, a hybrid structure-based and physics-based atomistic force field with an efficient sampling strategy is adopted to simulate a model di-domain protein against experimental paramagnetic relaxation enhancement (PRE) data that correspond to distance constraints. The molecular dynamics simulations produce a wide range of conformations depicted on a protein energy landscape. Subsequently, a conformational ensemble recovered with low-energy structures and the minimum-size restraint is identified in good agreement with experimental PRE rates, and the result is also supported by chemical shift perturbations and small-angle X-ray scattering data. It is illustrated that the regularizations of energy and ensemble-size prevent an arbitrary interpretation of protein conformations. Moreover, energy is found to serve as a critical control to refine the structure pool and prevent data overfitting, because the absence of energy regularization exposes ensemble construction to the noise from high-energy structures and causes a more ambiguous representation of protein conformations. Finally, we perform structure-ensemble optimizations with a topology-based structure pool, to enhance the understanding on the ensemble results from different sources of pool candidates. © 2018 Wiley Periodicals, Inc.

  19. Both Epistasis and Diversifying Selection Drive the Structural Evolution of the Ebola Virus Glycoprotein Mucin-Like Domain.

    Science.gov (United States)

    Ibeh, Neke; Nshogozabahizi, Jean Claude; Aris-Brosou, Stéphane

    2016-06-01

    Throughout the last 3 decades, Ebola virus (EBOV) outbreaks have been confined to isolated areas within Central Africa; however, the 2014 variant reached unprecedented transmission and mortality rates. While the outbreak was still under way, it was reported that the variant leading up to this outbreak evolved faster than previous EBOV variants, but evidence for diversifying selection was undetermined. Here, we test this selection hypothesis and show that while previous EBOV outbreaks were preceded by bursts of diversification, evidence for site-specific diversifying selection during the emergence of the 2014 EBOV clade is weak. However, we show strong evidence supporting an interplay between selection and correlated evolution (epistasis), particularly in the mucin-like domain (MLD) of the EBOV glycoprotein. By reconstructing ancestral structures of the MLD, we further propose a structural mechanism explaining how the substitutions that accumulated between 1918 and 1969 distorted the MLD, while more recent epistatic substitutions restored part of the structure, with the most recent substitution being adaptive. We suggest that it is this complex interplay between weak selection, epistasis, and structural constraints that has shaped the evolution of the 2014 EBOV variant. The role that selection plays in the emergence of viral epidemics remains debated, particularly in the context of the 2014 EBOV outbreak. Most critically, should such evidence exist, it is generally unclear how this relates to function and increased virulence. Here, we show that the viral lineage leading up to the 2014 outbreak underwent a complex interplay between selection and correlated evolution (epistasis) in a protein region that is critical for immune evasion. We then reconstructed the three-dimensional structure of this domain and showed that the initial mutations in this lineage deformed the structure, while subsequent mutations restored part of the structure. Along this mutational path, the

  20. Enhanced photocatalytic activity of supported TiO{sub 2} by selective surface modification of zeolite Y

    Energy Technology Data Exchange (ETDEWEB)

    Guesh, Kiros [Chemistry-Department, Addis Ababa University, P.O. Box 1176, Addis Ababa (Ethiopia); Mizan-Tepi University, P.O. Box 260, Mizan-Teferi (Ethiopia); Márquez-Álvarez, Carlos [Instituto de Catálisis y Petroleoquímica, CSIC, c/Marie Curie 2, 28049 Madrid (Spain); Chebude, Yonas [Chemistry-Department, Addis Ababa University, P.O. Box 1176, Addis Ababa (Ethiopia); Díaz, Isabel, E-mail: idiaz@icp.csic.es [Chemistry-Department, Addis Ababa University, P.O. Box 1176, Addis Ababa (Ethiopia); Instituto de Catálisis y Petroleoquímica, CSIC, c/Marie Curie 2, 28049 Madrid (Spain)

    2016-08-15

    Highlights: • XPS analysis confirmed that 50% of the Al was removed from the surface of zeolite Y. • Loaded TiO{sub 2} on the treated zeolites showed 12 times higher TORm than the parent zeolite. • Supported TiO{sub 2} showed very low leaching of TiO{sub 2} nanoparticles than non supported. - Abstract: Zeolite Y was treated using ammonium acetate and ammonium fluoride sequentially. As a consequence the aluminum from the surface was selectively removed. Then, loading with TiO{sub 2} (20 wt%) led to a final photocatalyst. The samples were characterized by X-ray diffraction (XRD), elemental analysis (ICP-OES), N{sub 2} adsorption, diffuse reflectance UV–vis spectroscopy (DRS), photoluminescence spectroscopy (PL), and X-ray photoelectron spectroscopy (XPS). It was found that 50% of the Al atoms were removed from the surface of the zeolite without affecting the framework structure. The TiO{sub 2}/treated zeolite sample yielded 92% photocatalytic degradation of 10 ppm methyl orange (MO), a model pollutant, while the TiO{sub 2}/parent zeolite converted only 7.6%. The mass normalized turnover rate (TOR{sub m}) of the treated zeolite loaded with TiO{sub 2} was about 12 times higher than that of the parent zeolite loaded with the same amount of TiO{sub 2} precursor. This higher photocatalytic activity of the TiO{sub 2} supported on treated zeolite can be attributed to a more efficient interaction of the TiO{sub 2} with the zeolite leading to higher adsorption capacity. Reusability of the photocatalysts was assessed by performing three consecutive reaction cycles that showed no significant loss of photocatalytic activity.

  1. Model structure learning: A support vector machine approach for LPV linear-regression models

    NARCIS (Netherlands)

    Toth, R.; Laurain, V.; Zheng, W-X.; Poolla, K.

    2011-01-01

    Accurate parametric identification of Linear Parameter-Varying (LPV) systems requires an optimal prior selection of a set of functional dependencies for the parametrization of the model coefficients. Inaccurate selection leads to structural bias while over-parametrization results in a variance

  2. Further HTGR core support structure reliability studies. Interim report No. 1

    International Nuclear Information System (INIS)

    Platus, D.L.

    1976-01-01

    Results of a continuing effort to investigate high temperature gas cooled reactor (HTGR) core support structure reliability are described. Graphite material and core support structure component physical, mechanical and strength properties required for the reliability analysis are identified. Also described are experimental and associated analytical techniques for determining the required properties, a procedure for determining number of tests required, properties that might be monitored by special surveillance of the core support structure to improve reliability predictions, and recommendations for further studies. Emphasis in the study is directed towards developing a basic understanding of graphite failure and strength degradation mechanisms; and validating analytical methods for predicting strength and strength degradation from basic material properties

  3. Column Selection for Biomedical Analysis Supported by Column Classification Based on Four Test Parameters.

    Science.gov (United States)

    Plenis, Alina; Rekowska, Natalia; Bączek, Tomasz

    2016-01-21

    This article focuses on correlating the column classification obtained from the method created at the Katholieke Universiteit Leuven (KUL), with the chromatographic resolution attained in biomedical separation. In the KUL system, each column is described with four parameters, which enables estimation of the FKUL value characterising similarity of those parameters to the selected reference stationary phase. Thus, a ranking list based on the FKUL value can be calculated for the chosen reference column, then correlated with the results of the column performance test. In this study, the column performance test was based on analysis of moclobemide and its two metabolites in human plasma by liquid chromatography (LC), using 18 columns. The comparative study was performed using traditional correlation of the FKUL values with the retention parameters of the analytes describing the column performance test. In order to deepen the comparative assessment of both data sets, factor analysis (FA) was also used. The obtained results indicated that the stationary phase classes, closely related according to the KUL method, yielded comparable separation for the target substances. Therefore, the column ranking system based on the FKUL-values could be considered supportive in the choice of the appropriate column for biomedical analysis.

  4. Voltammetric electronic tongue and support vector machines for identification of selected features in Mexican coffee.

    Science.gov (United States)

    Domínguez, Rocio Berenice; Moreno-Barón, Laura; Muñoz, Roberto; Gutiérrez, Juan Manuel

    2014-09-24

    This paper describes a new method based on a voltammetric electronic tongue (ET) for the recognition of distinctive features in coffee samples. An ET was directly applied to different samples from the main Mexican coffee regions without any pretreatment before the analysis. The resulting electrochemical information was modeled with two different mathematical tools, namely Linear Discriminant Analysis (LDA) and Support Vector Machines (SVM). Growing conditions (i.e., organic or non-organic practices and altitude of crops) were considered for a first classification. LDA results showed an average discrimination rate of 88% ± 6.53% while SVM successfully accomplished an overall accuracy of 96.4% ± 3.50% for the same task. A second classification based on geographical origin of samples was carried out. Results showed an overall accuracy of 87.5% ± 7.79% for LDA and a superior performance of 97.5% ± 3.22% for SVM. Given the complexity of coffee samples, the high accuracy percentages achieved by ET coupled with SVM in both classification problems suggested a potential applicability of ET in the assessment of selected coffee features with a simpler and faster methodology along with a null sample pretreatment. In addition, the proposed method can be applied to authentication assessment while improving cost, time and accuracy of the general procedure.

  5. An Expert System for Supporting the Design and Selection of Mechanical Equipment for Recreational Crafts

    Directory of Open Access Journals (Sweden)

    T. Gonciarz

    2014-06-01

    Full Text Available Expert Systems can be defined as computer programs, whose main task is to simulate a human expert, usually in a narrow field of expertise. Expert Systems have experienced tremendous growth and popularity since their commercial introduction in the early 1970’s. Today, Expert Systems are used in business, science, engineering, manufacturing and other engineering applications such as planning, scheduling, diagnosing equipment failures and are used in almost every stage of the manufacturing process and also in medicine and many other fields. Expert Systems belong to the field of artificial intelligence. An intelligent computer program that uses knowledge and inference procedures to solve problems that are difficult enough to require significant human expertise for the solution. The purpose of this paper is to present an Expert System which assists with the design of yachts and supports the selection of mechanical equipment for yachts and includes knowledge in the field of yachting engineering. Using the presented Expert System reduces the time during the design and production preparation process.

  6. LITERATURE REVIEWS TO SUPPORT ION EXCHANGE TECHNOLOGY SELECTION FOR MODULAR SALT PROCESSING

    International Nuclear Information System (INIS)

    King, W.

    2007-01-01

    This report summarizes the results of literature reviews conducted to support the selection of a cesium removal technology for application in a small column ion exchange (SCIX) unit supported within a high level waste tank. SCIX is being considered as a technology for the treatment of radioactive salt solutions in order to accelerate closure of waste tanks at the Savannah River Site (SRS) as part of the Modular Salt Processing (MSP) technology development program. Two ion exchange materials, spherical Resorcinol-Formaldehyde (RF) and engineered Crystalline Silicotitanate (CST), are being considered for use within the SCIX unit. Both ion exchange materials have been studied extensively and are known to have high affinities for cesium ions in caustic tank waste supernates. RF is an elutable organic resin and CST is a non-elutable inorganic material. Waste treatment processes developed for the two technologies will differ with regard to solutions processed, secondary waste streams generated, optimum column size, and waste throughput. Pertinent references, anticipated processing sequences for utilization in waste treatment, gaps in the available data, and technical comparisons will be provided for the two ion exchange materials to assist in technology selection for SCIX. The engineered, granular form of CST (UOP IE-911) was the baseline ion exchange material used for the initial development and design of the SRS SCIX process (McCabe, 2005). To date, in-tank SCIX has not been implemented for treatment of radioactive waste solutions at SRS. Since initial development and consideration of SCIX for SRS waste treatment an alternative technology has been developed as part of the River Protection Project Waste Treatment Plant (RPP-WTP) Research and Technology program (Thorson, 2006). Spherical RF resin is the baseline media for cesium removal in the RPP-WTP, which was designed for the treatment of radioactive waste supernates and is currently under construction in Hanford, WA

  7. LITERATURE REVIEWS TO SUPPORT ION EXCHANGE TECHNOLOGY SELECTION FOR MODULAR SALT PROCESSING

    Energy Technology Data Exchange (ETDEWEB)

    King, W

    2007-11-30

    This report summarizes the results of literature reviews conducted to support the selection of a cesium removal technology for application in a small column ion exchange (SCIX) unit supported within a high level waste tank. SCIX is being considered as a technology for the treatment of radioactive salt solutions in order to accelerate closure of waste tanks at the Savannah River Site (SRS) as part of the Modular Salt Processing (MSP) technology development program. Two ion exchange materials, spherical Resorcinol-Formaldehyde (RF) and engineered Crystalline Silicotitanate (CST), are being considered for use within the SCIX unit. Both ion exchange materials have been studied extensively and are known to have high affinities for cesium ions in caustic tank waste supernates. RF is an elutable organic resin and CST is a non-elutable inorganic material. Waste treatment processes developed for the two technologies will differ with regard to solutions processed, secondary waste streams generated, optimum column size, and waste throughput. Pertinent references, anticipated processing sequences for utilization in waste treatment, gaps in the available data, and technical comparisons will be provided for the two ion exchange materials to assist in technology selection for SCIX. The engineered, granular form of CST (UOP IE-911) was the baseline ion exchange material used for the initial development and design of the SRS SCIX process (McCabe, 2005). To date, in-tank SCIX has not been implemented for treatment of radioactive waste solutions at SRS. Since initial development and consideration of SCIX for SRS waste treatment an alternative technology has been developed as part of the River Protection Project Waste Treatment Plant (RPP-WTP) Research and Technology program (Thorson, 2006). Spherical RF resin is the baseline media for cesium removal in the RPP-WTP, which was designed for the treatment of radioactive waste supernates and is currently under construction in Hanford, WA

  8. Determinants of capital structure: An empirical study of companies from selected post-transition economies

    Directory of Open Access Journals (Sweden)

    Sasho Arsov

    2016-06-01

    Full Text Available The goal of this paper is to examine if there are any determinants that systematically influence the capital structure of the companies in the Balkan countries and to determine if any of the existing capital structure theories are relevant in their case. We apply a panel regression on a sample consisting of the largest and most frequently traded joint-stock companies from four countries. The results show that the larger companies and those with higher fixed asset investments exhibit higher leverage, while the more profitable companies and those with more tangible assets use less debt financing. Other variables, such as the concentration of company ownership, the riskiness of its operating profits and the effective tax rates have not been found statistically significant. These results, supported by the robustness tests, have confirmed our expectation that the managers in these countries do not set specific target leverage ratios, but instead follow a particular order in the selection of the sources of financing. In other words, the companies behave in accordance with the pecking order theory, which is a confirmation of our initial hypothesis. The governments of these countries should put more effort on stimulating the use of other sources of financing to relieve the possible excessive company dependence on the banking sector.

  9. Population structure of a widespread species under balancing selection: the case of Arbutus unedo L.

    Directory of Open Access Journals (Sweden)

    Xabier eSantiso

    2016-01-01

    Full Text Available Arbutus unedo L. is an evergreen shrub with a circum-Mediterranean distribution that also reaches the Eurosiberian region in northern Iberia, Atlantic France, and a disjunct population in southern Ireland. Due to the variety of climatic conditions across its distribution range, the populations of A. unedo were expected to display local adaptation. Conversely, common garden experiments revealed that diverse genotypes from a range of provenances produce similar phenotypes through adaptive plasticity, suggesting the action of stabilizing selection across its climatically heterogeneous range. Nonetheless, since an uniform response might also result from extensive gene flow, we have inferred the population structure of A. unedo and assessed whether its extended and largely one-dimensional range influences gene flow with the help of AFLP genotypes for 491 individuals from 19 populations covering the whole range of the species. As we had anticipated, gene flow is restricted in A. unedo, providing further support to the hypothesis that stabilizing selection is the most likely explanation for the homogeneous phenotypes along the range. The Euro-Siberian populations were not particularly isolated from the Mediterranean. Instead, there was a distinct genetic divide between the populations around the Mediterranean Sea and those sampled along Atlantic coasts from northern Africa up to Ireland. This genetic structure suggests the action of historic rather than biogeographic factors as it seems consistent with a scenario of independent glacial refugia in the Atlantic and Mediterranean portions of the range of A. unedo. Genetic exchange was likewise restricted within each set of populations. Nevertheless, IBD was stronger, and FST increased faster with distance, along the Atlantic, suggesting that gene flow might be larger among Mediterranean populations. Genetic diversity was significantly lower in NW Iberia and Ireland than in other populations whereas

  10. Population Structure of a Widespread Species under Balancing Selection: The Case of Arbutus unedo L.

    Science.gov (United States)

    Santiso, Xabier; Lopez, Lua; Retuerto, Rubén; Barreiro, Rodolfo

    2015-01-01

    Arbutus unedo L. is an evergreen shrub with a circum-Mediterranean distribution that also reaches the Eurosiberian region in northern Iberia, Atlantic France, and a disjunct population in southern Ireland. Due to the variety of climatic conditions across its distribution range, the populations of A. unedo were expected to display local adaptation. Conversely, common garden experiments revealed that diverse genotypes from a range of provenances produce similar phenotypes through adaptive plasticity, suggesting the action of stabilizing selection across its climatically heterogeneous range. Nonetheless, since a uniform response might also result from extensive gene flow, we have inferred the population structure of A. unedo and assessed whether its extended and largely one-dimensional range influences gene flow with the help of AFLP genotypes for 491 individuals from 19 populations covering the whole range of the species. As we had anticipated, gene flow is restricted in A. unedo, providing further support to the hypothesis that stabilizing selection is the most likely explanation for the homogeneous phenotypes along the range. The Euro-Siberian populations were not particularly isolated from the Mediterranean. Instead, there was a distinct genetic divide between the populations around the Mediterranean Sea and those sampled along Atlantic coasts from northern Africa up to Ireland. This genetic structure suggests the action of historic rather than biogeographic factors as it seems consistent with a scenario of independent glacial refugia in the Atlantic and Mediterranean portions of the range of A. unedo. Genetic exchange was likewise restricted within each set of populations. Nevertheless, isolation-by-distance (IBD) was stronger, and F ST increased faster with distance, along the Atlantic, suggesting that gene flow might be larger among Mediterranean populations. Genetic diversity was significantly lower in NW Iberia and Ireland than in other populations whereas

  11. The structure of occupational health nurses' support for return-to-work to workers with depression.

    Science.gov (United States)

    Hatanaka, Junko

    2016-07-29

    The present study aimed to explore the structure of occupational health nurses' support for return-to-work to workers with depression. Semi-structured interviews were conducted with 10 occupational health nurses who support workers returning to work. Data were analyzed using the Modified Grounded Theory Approach. The qualitatively analyzed data was grouped into 9 categories. The support for return-to-work was divided into 3 periods: (1) the first priority for recovery, (2) preparation for return-to-work, and (3) adaptation to work. There were indirect supports to workers such as "environmental arrangement for medical treatment," "connection," and "support form parties concerned about workers," and direct supports such as "readiness for medical treatment," "overcoming social and psychological problems," and "working life independence. " Direct support was facilitated by "construction of the relationship. " The occupational health nurses' philosophy was to support "profitable return-to-work for both the worker and the employer. " These processes were "support of confidence recovery process " to regain confidence lost through absence from work because of depression and to accomplish a smooth return-to-work. There were problems in each period corresponding to the return-to-work conditions, and occupational health nurses supported the employees in overcoming each problem. Moreover, it was said that cooperation with the parties concerned in the office would greatly influence the success or failure in the return-to-work support, and it was thought that direct supports and indirect supports to employees with respect to adjustment with the parties concerned in the office were necessary. The structure of occupational health nurses' supports was to support the confidence recovery process of workers by indirect and direct support at each period of return-to-work.

  12. Comparative Structural Analysis of ERa and ERb Bound to Selective Estrogen Agonists and Antagonists

    National Research Council Canada - National Science Library

    Greene, Geoffrey

    2001-01-01

    ...) complexed with receptor-selective estrogens and antiestrogens (SERMs) The crystallographic structures of ERalpha and ERbeta ligand binding domains complexed with cis-R,R-diethyl-tetrahydrochrysene-2,8-diol (R,R-THC...

  13. Comparative Structural Analysis of ERa and ERb Bound to Selective Estrogen Agonists and Antagonists

    National Research Council Canada - National Science Library

    Greene, Geoggrey

    2000-01-01

    ...) complexed with receptor-selective estrogens and antiestrogens (SERMs). The crystallographic structures of ERalpha and ERbeta ligand binding domains complexed with cis- R,R-diethyl-tetrahydrochrysene-2, 8 -diol (R,R-THC...

  14. Support structure concept for integration of ITER diagnostics in the port cell

    Energy Technology Data Exchange (ETDEWEB)

    Udintsev, V.S., E-mail: victor.udintsev@iter.org [ITER Organization, Route de Vinon sur Verdon, 13115 St. Paul-Lez-Durance (France); Portalès, M.; Giacomin, T.; Darcourt, O.; Direz, M.-F.; Martins, J.P.; Penot, C.; Arumugam, A.P.; Drevon, J.-M.; Friconneau, J.P.; Levesy, B.; Maquet, P.; Patel, K.M.; Pitcher, C.S. [ITER Organization, Route de Vinon sur Verdon, 13115 St. Paul-Lez-Durance (France); Popova, E. [Russian Federation Domestic Agency, Moscow (Russian Federation); Proust, M. [ITER Organization, Route de Vinon sur Verdon, 13115 St. Paul-Lez-Durance (France); Ronden, D.M.S. [DIFFER, Nieuwegein (Netherlands); Walker, C.I.; Walsh, M.J.; Watts, C. [ITER Organization, Route de Vinon sur Verdon, 13115 St. Paul-Lez-Durance (France)

    2013-10-15

    Highlights: ► An interspace support structure to support the diagnostic systems from the back of the upper and equatorial port plugs to the biological shield plug. ► Port cell support structures are foreseen to handle the equipment in the port cell. ► Both ISS and PCSS will be supported by means of RH rail system. ► The structures will be positioned with a certain tolerance. ► The proposed concepts are found to fulfil the needs for support of the diagnostics in ITER. -- Abstract: Development of the diagnostics for ITER tokamak, which is presently under construction by several international partners at Cadarache in France, is a major challenge because of severe environment, strict engineering requirements, and the need for high reliability in the measurements. The diagnostic systems in the upper, equatorial and lower port cells on ITER are designed to be integrated within the interspace and port cell support structures. These structures are interfacing with remote handling rail system for the cask operations, thus facilitating the removal and installation of the diagnostics in the port and hence minimizing time for working close to the tokamak. In this paper, the challenges associated with the integration of the diagnostics in the port interspace and port cell, as well as their solutions will be addressed and presented. The interspace and the port cell support structures, as well as their interfaces with the biological shield, will be discussed.

  15. Earthquake analysis with nonlinear soil-structure interaction and nonlinear supports of components

    International Nuclear Information System (INIS)

    Hansson, V.

    1990-01-01

    For the determination of the seismic response of a structure the soil-structure interaction in most cases is modelled by a mass-spring-damper-system. Normally design concepts for components and piping are based on linear calculations and stress limitations. A concept for a reactor building for the HTR 100 consisted of a relatively high structure compared with the dimensions of the foundation. The structure was comparatively deep embedded in the soil, so here the embedment influences significantly the soil-structure interaction. The assembly of reactor vessel, heat exchanger and circulators has a height of about 37 m. Supports are arranged at different levels. Due to temperature deformations of the vessel and of the support constructions small gaps at the supports may only be avoided by complicated constructions of the supports. Nonlinear analyses were performed for soil, building and component with all supports. The finite element analyses used time histories. In order to describe the radiation damping the hysteresis of the soil with 1 percent material damping was considered. Nonlinearities in the interface of soil and foundation and due to gaps and friction at the supports were taken into account. The stiffness of the support constructions influences reactions and accelerations to a high extent. Properly chosen stiffnesses of the support constructions lead to a behaviour similar to linear elastic behaviour. 13 figs

  16. The structured ancestral selection graph and the many-demes limit.

    Science.gov (United States)

    Slade, Paul F; Wakeley, John

    2005-02-01

    We show that the unstructured ancestral selection graph applies to part of the history of a sample from a population structured by restricted migration among subpopulations, or demes. The result holds in the limit as the number of demes tends to infinity with proportionately weak selection, and we have also made the assumptions of island-type migration and that demes are equivalent in size. After an instantaneous sample-size adjustment, this structured ancestral selection graph converges to an unstructured ancestral selection graph with a mutation parameter that depends inversely on the migration rate. In contrast, the selection parameter for the population is independent of the migration rate and is identical to the selection parameter in an unstructured population. We show analytically that estimators of the migration rate, based on pairwise sequence differences, derived under the assumption of neutrality should perform equally well in the presence of weak selection. We also modify an algorithm for simulating genealogies conditional on the frequencies of two selected alleles in a sample. This permits efficient simulation of stronger selection than was previously possible. Using this new algorithm, we simulate gene genealogies under the many-demes ancestral selection graph and identify some situations in which migration has a strong effect on the time to the most recent common ancestor of the sample. We find that a similar effect also increases the sensitivity of the genealogy to selection.

  17. Asymmetric actuating structure generates negligible influence on the supporting base for high performance scanning probe microscopies

    Science.gov (United States)

    Yi Yan, Gang; Bin Liu, Yong; Hua Feng, Zhi

    2014-02-01

    An asymmetric actuating structure generating negligible influence on the supporting base for high performance scanning probe microscopies is proposed in this paper. The actuator structure consists of two piezostacks, one is used for actuating while the other is for counterbalancing. In contrast with balanced structure, the two piezostacks are installed at the same side of the supporting base. The effectiveness of the structure is proved by some experiments with the actuators fixed to the free end of a cantilever. Experimental results show that almost all of the vibration modes of the cantilever are suppressed effectively at a wide frequency range of 90 Hz-10 kHz.

  18. Validity of a structured method of selecting abstracts for a plastic surgical scientific meeting

    NARCIS (Netherlands)

    van der Steen, LPE; Hage, JJ; Kon, M; Monstrey, SJ

    In 1999, the European Association of Plastic Surgeons accepted a structured method to assess and select the abstracts that are submitted for its yearly scientific meeting. The two criteria used to evaluate whether such a selection method is accurate were reliability and validity. The authors

  19. Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors - A Structural Perspective of Ligands and Mutants

    DEFF Research Database (Denmark)

    Harpsøe, Kasper; Isberg, Vignir; Tehan, Benjamin G

    2015-01-01

    modulators. In this analysis, we make the first comprehensive structural comparison of all metabotropic glutamate receptors, placing selective negative allosteric modulators and critical mutants into the detailed context of the receptor binding sites. A better understanding of how the different m......Glu allosteric modulator binding modes relates to selective pharmacological actions will be very valuable for rational design of safer drugs....

  20. TRUSSELATOR - On-Orbit Fabrication of High Performance Support Structures for Solar Arrays, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The Trusselator technology will enable on-orbit fabrication of support structures for high-power solar arrays and large antennas, achieving order-of-magnitude...

  1. Grain structure evolution in Inconel 718 during selective electron beam melting

    Energy Technology Data Exchange (ETDEWEB)

    Helmer, H.; Bauereiß, A., E-mail: Andreas.Bauereiss@fau.de; Singer, R.F.; Körner, C.

    2016-06-21

    Selective electron beam melting (SEBM) is an additive manufacturing method where complex parts are built from metal powders in layers of typically 50 µm. An electron beam is used for heating (about 900 °C building temperature) and selective melting of the material. The grain structure evolution is a result of the complex thermal and hydrodynamic conditions in the melt pool. We show how different scanning strategies can be used to produce either a columnar grain structure with a high texture in building direction or an equiaxed fine grained structure. Numerical simulations of the selective melting process are applied to study the fundamental mechanisms responsible for differing grain structures. It is shown, that the direction of the thermal gradient during solidification can be altered by scanning strategies to acquire either epitaxial growth or stray grains. We show that it is possible to locally alter the grain structure of a part, thus allowing tailoring of the mechanical properties.

  2. Development and Application of an Evaluation Method for the Supporting Structure

    International Nuclear Information System (INIS)

    Lee, Young Ho; Lee, Kang Hee; Kim, Jae Yong; Yoon, Kyung Ho; Kim, Hyung Kyu

    2009-01-01

    A dual cooled fuel (i.e. annular fuel) has both internal and external cooling which would allow a substantial increase in power density and safety margins compared to a solid fuel in operating PWR plants. When considering the sufficient cross-sectional area of the internal cooling channel and an acceptable amount of fuel pellet, the diameter of an outer tube should be increased for applying the compatible design concept of the dual cooled fuel to current operating PWRs. However, this results in a narrow gap between a dual cooled fuel rod and its supporting structure due to a fixed fuel assembly size. As all the fuel rods should be supported with safety and reliability for operating periods, any kinds of supporting structures should be installed in a dual cooled fuel assembly. Consequently, the positions of supporting structures around the dual cooled fuel rod should be modified from the rod-to-rod center to subchannel regions of grid structure and their shapes are designed and improved based on the advantages of current spacer grid technologies. Even though the vibration characteristics of the dual cooled fuel rod itself were not systematically evaluated, the characteristics of designed supporting structures and their wear resistances should be evaluated at the initial development stage. In this study, the evaluation method for the characteristics of designed supporting structures is developed by using a new test rig and compared with the analytical results. The final objective is to develop the evaluation method of their fretting wear resistances which accommodates the various shape of supporting structures without actual Zirconium supporting structures

  3. Deliverable D74.2. Probabilistic analysis methods for support structures

    DEFF Research Database (Denmark)

    Gintautas, Tomas

    2018-01-01

    Relevant Description: Report describing the probabilistic analysis for offshore substructures and results attained. This includes comparison with experimental data and with conventional design. Specific targets: 1) Estimate current reliability level of support structures 2) Development of basis...... for probabilistic calculations and evaluation of reliability for offshore support structures (substructures) 3) Development of a probabilistic model for stiffness and strength of soil parameters and for modeling geotechnical load bearing capacity 4) Comparison between probabilistic analysis and deterministic...

  4. A group-based spatial decision support system for wind farm site selection in Northwest Ohio

    International Nuclear Information System (INIS)

    Gorsevski, Pece V.; Cathcart, Steven C.; Mirzaei, Golrokh; Jamali, Mohsin M.; Ye, Xinyue; Gomezdelcampo, Enrique

    2013-01-01

    The purpose of this paper is to demonstrate the benefits of applying a spatial decision support system (SDSS) framework for evaluating the suitability for wind farm siting in Northwest Ohio. The multiple criteria evaluation (MCE) prototype system is intended for regional planning but also for promoting group decision making that could involve participants with different interests in the development of decision alternatives. The framework integrates environmental and economic criteria and builds a hierarchy for wind farm siting using weighted linear combination (WLC) techniques and GIS functionality. The SDSS allows the multiple participants to interact and develop an understanding of the spatial data for assigning importance values to each factor. The WLC technique is used to combine the assigned values with map layers, which are standardized using fuzzy set theory, to produce individual suitability maps. The maps created by personal preferences from the participants are aggregated for producing a group solution using the Borda method. Sensitivity analysis is performed on the group solution to examine how small changes in the factor weights affect the calculated suitability scores. The results from the sensitivity analysis are intended to aid understanding of compromised solutions through changes in the input data from the participant's perspective. - Highlights: ► We present a prototype tool that we developed for wind farm site selection. ► Multiple participants rank the factors for promoting group-based decision making. ► The factors are aggregated by WLC technique to generate maps from participants. ► Group-based solution uses Borda method to aggregate the maps from participants. ► Sensitivity analysis is performed on the group solution to examine solution affects

  5. Structural Study and Modification of Support Layer for Forward Osmosis Membranes

    KAUST Repository

    Shi, Meixia

    2016-06-01

    Water scarcity is a serious global issue, due to the increasing population and developing economy, and membrane technology is an essential way to address this problem. Forward osmosis (FO) is an emerging membrane process, due to its low energy consumption (not considering the draw solute regeneration). A bottleneck to advance this technology is the design of the support layer for FO membranes to minimize the internal concentration polarization. In this dissertation, we focus on the structural study and modification of the support layer for FO membranes. Firstly, we digitally reconstruct different membrane morphologies in 3D and propose a method for predicting performance in ultrafiltration operations. Membranes with analogous morphologies are later used as substrate for FO membranes. Secondly, we experimentally apply substrates with different potentially suitable morphologies as an FO support layer. We investigate their FO performance after generating a selective polyamide layer on the top, by interfacial polymerization. Among the different substrates we include standard asymmetric porous membranes prepared from homopolymers, such as polysulfone. Additionally block copolymer membrane and Anodisc alumina membrane are chosen based on their exceptional structures, with cylindrical pores at least in part. 3D digitally reconstructed porous substrates, analogous to those investigated for ultrafiltration, are then used to model the performance in FO operation. Finally, we analyze the effect of intermediate layers between the porous substrate and the interfacial polymerized layer. We investigate two materials including chitosan and hydrogel. The main results are the following. Pore-scale modeling for digital membrane generation effectively predicts the velocity profile in different layers of the membrane and the performance in UF experiments. Flow simulations confirm the advantage of finger-like substrates over sponge-like ones, when high water permeance is sought

  6. Influence of material selection on the structural behavior of a wave energy converter

    Directory of Open Access Journals (Sweden)

    Cândida M. S. P. Malça

    2014-09-01

    Full Text Available In the last decades, the world energy demand has raised significantly. Concerning this fact, wave energy should be considered as a valid alternative for electricity production. Devices suitable to harness this kind of renewable energy source and convert it into electricity are not yet commercially competitive. This paper is focused on the selection and analysis of different types of elastic materials and their influence on the structural behavior of a wave energy converter (WEC. After a brief characterization of the device, a tridimensional computer aided design (3D CAD numerical model was built and several finite element analyses (FEA were performed through a commercial finite element code. The main components of the WEC, namely the buoy, supporting cables and hydraulic cylinder were simulated assuming different materials. The software used needs, among other parameters, the magnitude of the resultant hydrodynamic forces acting upon the floating buoy obtained from a WEC time domain simulator (TDS which was built based on the WEC dynamic model previously developed. The Von Mises stress gradients and displacement fields determined by the FEA demonstrated that, regardless of the WEC component, the materials with low Young's modulus seems to be unsuitable for this kind of application. The same is valid for the material yield strength since materials with a higher yield strength lead to a better structural behavior of WEC components because lower stress and displacement values were obtained. The developed 3D CAD numerical model showed to be suitable to analyze different combinations of structural conditions. They could depend of different combinations of buoy position and resultant hydrodynamic forces acting upon the buoy, function of the specific sea wave parameters found on the deployment site.

  7. Monte Carlo simulation - a powerful tool to support experimental activities in structure reliability

    International Nuclear Information System (INIS)

    Yuritzinn, T.; Chapuliot, S.; Eid, M.; Masson, R.; Dahl, A.; Moinereau, D.

    2003-01-01

    Monte-Carlo Simulation (MCS) can have different uses in supporting structure reliability investigations and assessments. In this paper we focus our interest on the use of MCS as a numerical tool to support the fitting of the experimental data related to toughness experiments. (authors)

  8. Tuning the Electronic Structure of Titanium Oxide Support to Enhance the Electrochemical Activity of Platinum Nanoparticles

    KAUST Repository

    Shi, Feifei; Baker, L. Robert; Hervier, Antoine; Somorjai, Gabor A.; Komvopoulos, Kyriakos

    2013-01-01

    on pristine TiO2 support were achieved by tuning the electronic structure of the titanium oxide support of Pt nanoparticle catalysts. This was accomplished by adding oxygen vacancies or doping with fluorine. Experimental trends are interpreted in the context

  9. Prototype of a diagnostic decision support tool for structural damage in masonry

    NARCIS (Netherlands)

    De Vent, I.A.E.

    2011-01-01

    This prototype of a diagnostic decision support tool for structural damage in traditional masonry is the result of a PhD research project. The research project has aimed to improve and facilitate the diagnostic process by offering support in the initial phase in which hypotheses are generated. The

  10. Stress analysis of LOFT containment vessel attachments for the mainsteam and feedwater piping support structures

    International Nuclear Information System (INIS)

    Finicle, D.P.

    1977-01-01

    The LOFT Containment Vessel attachments for the Mainsteam and Feedwater Piping Support Structures have been analyzed for operating and faulted loading conditions. This report contains the analysis of the connections to the containment vessel for the most current design and loading. Also contained in this report is the analysis of the piping supports

  11. Experimental Studies of Turbulent Intensity around a Tidal Turbine Support Structure

    Directory of Open Access Journals (Sweden)

    Stuart Walker

    2017-04-01

    Full Text Available Tidal stream energy is a low-carbon energy source. Tidal stream turbines operate in a turbulent environment, and the effect of the structure between the turbine and seabed on this environment is not fully understood. An experimental study using 1:72 scale models based on a commercial turbine design was carried out to study the support structure influence on turbulent intensity around the turbine blades. The study was conducted using the wave-current tank at the Laboratory of Maritime Engineering (LABIMA, University of Florence. A realistic flow environment (ambient turbulent intensity = 11% was established. Turbulent intensity was measured upstream and downstream of a turbine mounted on two different support structures (one resembling a commercial design, the other the same with an additional vertical element, in order to quantify any variation in turbulence and performance between the support structures. Turbine drive power was used to calculate power generation. Acoustic Doppler velocimetry (ADV was used to record and calculate upstream and downstream turbulent intensity. In otherwise identical conditions, performance variation of only 4% was observed between two support structures. Turbulent intensity at 1, 3 and 5 blade diameters, both upstream and downstream, showed variation up to 21% between the two cases. The additional turbulent structures generated by the additional element of the second support structure appears to cause this effect, and the upstream propagation of turbulent intensity is believed to be permitted by surface waves. This result is significant for the prediction of turbine array performance.

  12. Selecting highly structure-specific antibodies using structured synthetic mimics of the cystine knot protein sclerostin

    NARCIS (Netherlands)

    Back, J.W.; Frisch, C.; Van Pee, K.; Boschert, V.; van Vught, R.; Puijk, W.; Mueller, T. D.; Knappik, A.; Timmerman, P.

    2012-01-01

    Antibodies directed against specific regions of a protein have traditionally been raised against full proteins, protein domains or simple unstructured peptides, containing contiguous stretches of primary sequence. We have used a new approach of selecting antibodies against restrained peptides

  13. Calcium oxide supported gold nanoparticles as catalysts for the selective epoxidation of styrene by t-butyl hydroperoxide.

    Science.gov (United States)

    Dumbre, Deepa K; Choudhary, Vasant R; Patil, Nilesh S; Uphade, Balu S; Bhargava, Suresh K

    2014-02-01

    Gold nanoparticles are deposited on basic CaO supports as catalysts for the selective conversion of styrene into styrene oxide. Synthetic methods, gold loading and calcination temperatures are varied to permit an understanding of their influence on gold nanoparticle size, the presence of cationic gold species and the nature of interaction between the gold nanoparticles and the CaO support. Based on these studies, optimal conditions are designed to make the Au/CaO catalyst efficient for the selective epoxidation of styrene. Copyright © 2013 Elsevier Inc. All rights reserved.

  14. The Acceptance of Universalism: The Importance of Selected Aspects of School Structure.

    Science.gov (United States)

    Martin, Robert A.

    This report describes a study that investigated empirically the relationships between selected aspects of the organizational structure of elementary schools and the extent to which students endorsed the norm of universalism. Four aspects of structure were studied: degree of departmentalization, school enrollment, student-teacher ratio, and extent…

  15. The structure of XIAP BIR2: understanding the selectivity of the BIR domains

    Energy Technology Data Exchange (ETDEWEB)

    Lukacs, Christine, E-mail: cmlukacs230@gmail.com; Belunis, Charles; Crowther, Robert; Danho, Waleed; Gao, Lin; Goggin, Barry; Janson, Cheryl A.; Li, Shirley; Remiszewski, Stacy; Schutt, Andrew [Hoffmann-La Roche, 340 Kingsland Street, Nutley, NJ 07110 (United States); Thakur, Manish K.; Singh, Saroj K.; Swaminathan, Srinivasan; Pandey, Rajat; Tyagi, Rajiv; Gosu, Ramachandraiah; Kamath, Ajith V. [Jubilant Biosys Ltd, Bangalore (India); Kuglstatter, Andreas, E-mail: cmlukacs230@gmail.com [Hoffmann-La Roche, 340 Kingsland Street, Nutley, NJ 07110 (United States)

    2013-09-01

    The high-resolution crystal structures of apo and peptide-bound XIAP BIR2 are presented and compared with BIR3 structures to understand their selectivity. This crystal system can be used to determine the structures of BIR2–inhibitor complexes. XIAP, a member of the inhibitor of apoptosis family of proteins, is a critical regulator of apoptosis. Inhibition of the BIR domain–caspase interaction is a promising approach towards treating cancer. Previous work has been directed towards inhibiting the BIR3–caspase-9 interaction, which blocks the intrinsic apoptotic pathway; selectively inhibiting the BIR2–caspase-3 interaction would also block the extrinsic pathway. The BIR2 domain of XIAP has successfully been crystallized; peptides and small-molecule inhibitors can be soaked into these crystals, which diffract to high resolution. Here, the BIR2 apo crystal structure and the structures of five BIR2–tetrapeptide complexes are described. The structural flexibility observed on comparing these structures, along with a comparison with XIAP BIR3, affords an understanding of the structural elements that drive selectivity between BIR2 and BIR3 and which can be used to design BIR2-selective inhibitors.

  16. Rigidly framed earth retaining structures thermal soil structure interaction of buildings supporting unbalanced lateral earth pressures

    CERN Document Server

    Aboumoussa, Walid

    2014-01-01

    Structures placed on hillsides often present a number of challenges and a limited number of economical choices for site design. An option sometimes employed is to use the building frame as a retaining element, comprising a Rigidly Framed Earth Retaining Structure (RFERS). The relationship between temperature and earth pressure acting on RFERS, is explored in this monograph through a 4.5 year monitoring program of a heavily instrumented in service structure. The data indicated that the coefficient of earth pressure behind the monitored RFERS had a strong linear correlation with temperature. The study also revealed that thermal cycles, rather than lateral earth pressure, were the cause of failure in many structural elements. The book demonstrates that depending on the relative stiffness of the retained soil mass and that of the structural frame, the developed lateral earth pressure, during thermal expansion, can reach magnitudes several times larger than those determined using classical earth pressure theories....

  17. Selectable high-yield recombinant protein production in human cells using a GFP/YFP nanobody affinity support.

    Science.gov (United States)

    Schellenberg, Matthew J; Petrovich, Robert M; Malone, Christine C; Williams, R Scott

    2018-03-25

    Recombinant protein expression systems that produce high yields of pure proteins and multi-protein complexes are essential to meet the needs of biologists, biochemists, and structural biologists using X-ray crystallography and cryo-electron microscopy. An ideal expression system for recombinant human proteins is cultured human cells where the correct translation and chaperone machinery are present. However, compared to bacterial expression systems, human cell cultures present several technical challenges to their use as an expression system. We developed a method that utilizes a YFP fusion-tag to generate recombinant proteins using suspension-cultured HEK293F cells. YFP is a dual-function tag that enables direct visualization and fluorescence-based selection of high expressing clones for and rapid purification using a high-stringency, high-affinity anti-GFP/YFP nanobody support. We demonstrate the utility of this system by expressing two large human proteins, TOP2α (340 KDa dimer) and a TOP2β catalytic core (260 KDa dimer). This robustly and reproducibly yields >10 mg/L liter of cell culture using transient expression or 2.5 mg/L using stable expression. Published 2018. This article is a US Government work and is in the public domain in the USA.

  18. Analytical Support for Selecting the Best Investment Project in the Presence of Fuzzy Data

    Directory of Open Access Journals (Sweden)

    Kotsyuba Oleksiy S.

    2017-12-01

    Full Text Available The article is dedicated to the problem of optimal choice in the field of real investments in case of fuzzy estimates of financial and economic parameters. The general methodological basis of the research is an integrated approach to solving decision-making problems under conditions of uncertainty, conflict, and risk generated by them, based on the game theory, proposed by R. I. Trukhayev. In recent decades, it has been actively developed in papers by the followers of the scientific school of riskology under the leadership of V. V. Vitlinsky. One of the system-forming components of the above integration and game methodology is the classifier of information situations (there singled out seven of them. In this case, the description of possible states of the economic environment by a fuzzy set (a subset corresponds to the seventh information situation. An attempt was made to develop a methodical apparatus for the task of selecting the best investment project from a variety of alternative projects in the presence of fuzzy data. As a result, a model based on the use of convolutions of local criteria is formulated. In accordance with the accepted methodological guidelines, the structure of the generalized (integral indicator of the economic attractiveness (efficiency of real investment provides for three hierarchical levels: 1 the level of detailed criteria in terms of partial criteria (financial effect, profitability, payback period, 2 the level of partial criteria, 3 the level presenting the very generalized indicator. In the basic version of the proposed model, among the possible techniques (methods for aggregating indicators detailing the aspects of fuzzy estimates of partial criteria, the preference is given to the method by which they are joined by a combined, additive and multiplicative convolution.

  19. Multi-criteria decision making support tool for freight integrators: selecting the most sustainable alternative

    Directory of Open Access Journals (Sweden)

    G. Simongáti

    2010-03-01

    Full Text Available Sustainable development has turned into a daily concept by now. Similarly, sustainable transport also appears increasingly often, primarily in transport policy and strategic plans. However, it would be equally important if we could apply this aspect for certain activities such as haulage and forwarding that are a part of transport. Today, forwarders select an optimal alternative concerning only the criteria related to the economic effectiveness of the transport task. In many cases, shippers are not aware neither of the concept of sustainable transport nor of harmful effects they generate. Hence, although there is a concept of ‘freight integrator’, only very few are able to meet the requirements laid down for it. No widespread method has been developed yet to compare transportation options. A similar situation can be faced discussing a traditional, purely economic approach and a theoretical modern aspect that would be in accordance with the principles of sustainable transport. The model that was developed at the Department of Aircraft and Ships of Budapest University of Technology and Economics was designed specifically to compare various options in terms of sustainability. The indicators as the elements of decision-making criteria applied in the model were derived from the indicators used for assessing the transport sector but modified according to the requirements of the decision-making task for a freight integrator. Finally, such sustainable performance index of certain alternatives is determined by two fundamentally different aggregation methods as ‘fineness index’. This article presents the model structure and application using a concrete example.

  20. Preliminary design of offshore wind turbine support structures : The importance of proper mode shape estimation

    NARCIS (Netherlands)

    Van der Male, P.

    2013-01-01

    Offshore wind turbines are highly exposed to timevarying loads. For support structures, estimation of the fatigue damage during the lifetime of the structure is an essential design aspect. This already applies for the preliminary design stage. In determining the dynamic amplification in the

  1. Maternal Structure and Autonomy Support in Conversations about the Past: Contributions to Children's Autobiographical Memory

    Science.gov (United States)

    Cleveland, Emily Sutcliffe; Reese, Elaine

    2005-01-01

    The authors examined the contributions of maternal structure and autonomy support to children's collaborative and independent reminiscing. Fifty mother-child dyads discussed past experiences when the children were 40 and 65 months old. Children also discussed past events with an experimenter at each age. Maternal structure and autonomy support…

  2. Steady-state response of periodically supported structures to a moving load

    NARCIS (Netherlands)

    Metrikine, A.V.; Wolfert, A.R.M.; Vrouwenvelder, A.C.W.M.

    1999-01-01

    Steady-state vibrations of periodically supported structures under a moving load are analytically investigated. The following three structures are considered: an overhead power line for a train, a long suspended bridge and a railway track. The study is based on the application of so-called

  3. Review. Supporting problem structuring with computer-based tools in participatory forest planning

    Energy Technology Data Exchange (ETDEWEB)

    Hujala, T.; Khadka, C.; Wolfslehner, B.; Vacik, H.

    2013-09-01

    Aim of study: This review presents the state-of-art of using computerized techniques for problem structuring (PS) in participatory forest planning. Frequency and modes of using different computerized tool types and their contribution for planning processes as well as critical observations are described, followed by recommendations on how to better integrate PS with the use of forest decision support systems. Area of study: The reviewed research cases are from Asia, Europe, North-America, Africa and Australia. Material and methods: Via Scopus search and screening of abstracts, 32 research articles from years 2002-2011 were selected for review. Explicit and implicit evidence of using computerized tools for PS was recorded and assessed with content-driven qualitative analysis. Main results: GIS and forest-specific simulation tools were the most prevalent software types whereas cognitive modelling software and spreadsheet and calculation tools were less frequently used, followed by multi-criteria and interactive tools. The typical use type was to provide outputs of simulation–optimization or spatial analysis to negotiation situations or to compile summaries or illustrations afterwards; using software during group negotiation to foster interaction was observed only in a few cases. Research highlights: Expertise in both decision support systems and group learning is needed to better integrate PS and computerized decision analysis. From the knowledge management perspective, it is recommended to consider how the results of PS —e.g. conceptual models— could be stored into a problem perception database, and how PS and decision making could be streamlined by retrievals from such systems. (Author)

  4. Review. Supporting problem structuring with computer-based tools in participatory forest planning

    Directory of Open Access Journals (Sweden)

    T. Hujala

    2013-07-01

    Full Text Available Aim of study: This review presents the state-of-art of using computerized techniques for problem structuring (PS in participatory forest planning. Frequency and modes of using different computerized tool types and their contribution for planning processes as well as critical observations are described, followed by recommendations on how to better integrate PS with the use of forest decision support systems.Area of study: The reviewed research cases are from Asia, Europe, North-America, Africa and Australia.Materials and methods: Via Scopus search and screening of abstracts, 32 research articles from years 2002–2011 were selected for review. Explicit and implicit evidence of using computerized tools for PS was recorded and assessed with content-driven qualitative analysis.Main results: GIS and forest-specific simulation tools were the most prevalent software types whereas cognitive modelling software and spreadsheet and calculation tools were less frequently used, followed by multi-criteria and interactive tools. The typical use type was to provide outputs of simulation–optimization or spatial analysis to negotiation situations or to compile summaries or illustrations afterwards; using software during group negotiation to foster interaction was observed only in a few cases.Research highlights: Expertise in both decision support systems and group learning is needed to better integrate PS and computerized decision analysis. From the knowledge management perspective, it is recommended to consider how the results of PS – e.g. conceptual models – could be stored into a problem perception database, and how PS and decision making could be streamlined by retrievals from such systems.Keywords: facilitated modeling; group negotiation; knowledge management; natural resource management; PSM; soft OR; stakeholders.

  5. The Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor Selectivity

    Energy Technology Data Exchange (ETDEWEB)

    MacPherson, Iain S.; Kirubakaran, Sivapriya; Gorla, Suresh Kumar; Riera, Thomas V.; D’Aquino, J. Alejandro; Zhang, Minjia; Cuny, Gregory D.; Hedstrom, Lizbeth (BWH); (Brandeis)

    2010-03-29

    Cryptosporidium parvum is a potential biowarfare agent, an important AIDS pathogen, and a major cause of diarrhea and malnutrition. No vaccines or effective drug treatment exist to combat Cryptosporidium infection. This parasite relies on inosine 5{prime}-monophosphate dehydrogenase (IMPDH) to obtain guanine nucleotides, and inhibition of this enzyme blocks parasite proliferation. Here, we report the first crystal structures of CpIMPDH. These structures reveal the structural basis of inhibitor selectivity and suggest a strategy for further optimization. Using this information, we have synthesized low-nanomolar inhibitors that display 10{sup 3} selectivity for the parasite enzyme over human IMPDH2.

  6. Graduating to Postdoc: Information-Sharing in Support of Organizational Structures and Needs

    Science.gov (United States)

    Keller, Richard M.; Lucas, Paul J.; Compton, Michael M.; Stewart, Helen J.; Baya, Vinod; DelAlto, Martha

    1999-01-01

    The deployment of information-sharing systems in large organizations can significantly impact existing policies and procedures with regard to authority and control over information. Unless information-sharing systems explicitly support organizational structures and needs, these systems will be rejected summarily. The Postdoc system is a deployed Web-based information-sharing system created specifically to address organizational needs. Postdoc contains various organizational support features including a shared, globally navigable document space, as well as specialized access control, distributed administration, and mailing list features built around the key notion of hierarchical group structures. We review successes and difficulties in supporting organizational needs with Postdoc

  7. Regression analysis of pulsed eddy current signals for inspection of steam generator tube support structures

    International Nuclear Information System (INIS)

    Buck, J.; Underhill, P.R.; Mokros, S.G.; Morelli, J.; Krause, T.W.; Babbar, V.K.; Lepine, B.

    2015-01-01

    Nuclear steam generator (SG) support structure degradation and fouling can result in damage to SG tubes and loss of SG efficiency. Conventional eddy current technology is extensively used to detect cracks, frets at supports and other flaws, but has limited capabilities in the presence of multiple degradation modes or fouling. Pulsed eddy current (PEC) combined with principal components analysis (PCA) and multiple linear regression models was examined for the inspection of support structure degradation and SG tube off-centering with the goal of extending results to include additional degradation modes. (author)

  8. Strength Analysis of a Large-Size Supporting Structure for an Offshore Wind Turbine

    Directory of Open Access Journals (Sweden)

    Niklas Karol

    2017-04-01

    Full Text Available The offshore wind power industry is the branch of electric energy production from renewable sources which is most intensively developed in EU countries. At present, there is a tendency to install larger-power wind turbines at larger distances from the seashore, on relatively deep waters. Consequently, technological solutions for new supporting structures intended for deeper water regions are undergoing rapid development now. Various design types are proposed and analysed, starting from gravitational supports (GBS, through monopiles and 3D frame structures (jackets, tripods, and ending with floating and submerged supports anchored to the seabed by flexible connectors, including TLP type solutions.

  9. Effects of supporting structures on dynamic response of nuclear power plant equipment and piping systems

    International Nuclear Information System (INIS)

    Stoykovich, M.

    1982-01-01

    This paper presents the evaluation of the effects of supporting structures in dynamic analysis of equipment or piping systems, which involves formulations for determining reduced stiffness and mass matrices associated with the number of degrees of freedom corresponding to the support nodal points of a finite element model. Also, evaluation of a composite damping matrix associated with different damping properties of supporting structures, equipment, and piping systems is considered. Determination of spring constants, effective masses and mass moments of inertia, and damping values as fractions of critical damping on the basis of the theory of rigid bases on the surfaces of an elastic halfspace is demonstrated

  10. Rate and selectivity modification in Fischer-Tropsch synthesis over charcoal supported molybdenum by forced concentration cycling

    International Nuclear Information System (INIS)

    Dun, J.W.; Gulari, E.

    1985-01-01

    Forced concentration cycling of the feed between pure CO and pure H/sub 2/ was used to successfully change both the selectivities and reactivities of promoted and unpromoted charcoal supported molybdenum catalysts in Fischer-Tropsch synthesis. It was found that with the unpromoted catalyst the rate enhancement increases with temperature and selectivity shifts towards methane. At the lower temperatures concentration cycling increases selectivity to ethane and higher hydrocarbons to levels only achievable with promised catalysts. Periodic operation with the potassium promoted catalyst results in small rate enhancements but the olefin to paraffin ratio is dramatically changed without changing the carbon number distribution

  11. Degradation and Reinforcement of Industrial Gas Tank Support Structures. Thirty-Year Long Monitoring

    Science.gov (United States)

    Krentowski, Janusz R.; Knyziak, Piotr

    2017-10-01

    An analysis of reinforced concrete supporting structures of more than a dozen liquid gas tanks mounted on tower support structures located at different sites on Poland’s territory is presented. Stability testing of the degraded structures was carried out over a period of 30 years and pointed out significant defects that prevented safe operation of the tanks containing hazardous medium. Analysing complex stress states, as well as displacements of shell structure components, the authors developed a concept of strengthening the structures. Initial repair works, which had been carried out without proper supervision, failed to meet the mandatory requirements and were not compatible with the original design solutions. After several years of operation of the reinforced structures, their degradation states were assessed again. The next stage of repair works was carried out under the supervision of the authors together with authorized representatives of the investors.

  12. De Novo generation of molecular structures using optimization to select graphs on a given lattice

    DEFF Research Database (Denmark)

    Bywater, R.P.; Poulsen, Thomas Agersten; Røgen, Peter

    2004-01-01

    A recurrent problem in organic chemistry is the generation of new molecular structures that conform to some predetermined set of structural constraints that are imposed in an endeavor to build certain required properties into the newly generated structure. An example of this is the pharmacophore...... model, used in medicinal chemistry to guide de novo design or selection of suitable structures from compound databases. We propose here a method that efficiently links up a selected number of required atom positions while at the same time directing the emergent molecular skeleton to avoid forbidden...... positions. The linkage process takes place on a lattice whose unit step length and overall geometry is designed to match typical architectures of organic molecules. We use an optimization method to select from the many different graphs possible. The approach is demonstrated in an example where crystal...

  13. Seismic reliability assessment of RC structures including soil–structure interaction using wavelet weighted least squares support vector machine

    International Nuclear Information System (INIS)

    Khatibinia, Mohsen; Javad Fadaee, Mohammad; Salajegheh, Javad; Salajegheh, Eysa

    2013-01-01

    An efficient metamodeling framework in conjunction with the Monte-Carlo Simulation (MCS) is introduced to reduce the computational cost in seismic reliability assessment of existing RC structures. In order to achieve this purpose, the metamodel is designed by combining weighted least squares support vector machine (WLS-SVM) and a wavelet kernel function, called wavelet weighted least squares support vector machine (WWLS-SVM). In this study, the seismic reliability assessment of existing RC structures with consideration of soil–structure interaction (SSI) effects is investigated in accordance with Performance-Based Design (PBD). This study aims to incorporate the acceptable performance levels of PBD into reliability theory for comparing the obtained annual probability of non-performance with the target values for each performance level. The MCS method as the most reliable method is utilized to estimate the annual probability of failure associated with a given performance level in this study. In WWLS-SVM-based MCS, the structural seismic responses are accurately predicted by WWLS-SVM for reducing the computational cost. To show the efficiency and robustness of the proposed metamodel, two RC structures are studied. Numerical results demonstrate the efficiency and computational advantages of the proposed metamodel for the seismic reliability assessment of structures. Furthermore, the consideration of the SSI effects in the seismic reliability assessment of existing RC structures is compared to the fixed base model. It shows which SSI has the significant influence on the seismic reliability assessment of structures.

  14. Developing an efficient decision support system for non-traditional machine selection: an application of MOORA and MOOSRA

    Directory of Open Access Journals (Sweden)

    Asis Sarkar

    2015-01-01

    Full Text Available The purpose of this paper is to find out an efficient decision support method for non-traditional machine selection. It seeks to analyze potential non-traditional machine selection attributes with a relatively new MCDM approach of MOORA and MOOSRA method. The use of MOORA and MOOSRA method has been adopted to tackle subjective evaluation of information collected from an expert group. An example case study is shown here for better understanding of the said selection module which can be effectively applied to any other decision-making scenario. The method is not only computationally very simple, easily comprehensible, and robust, but also believed to have numerous subjective attributes. The rankings are expected to provide good guidance to the managers of an organization to select a feasible non-traditional machine. It shall also provide a good insight for the non-traditional machine manufacturer who might encourage research work concerning non-traditional machine selection.

  15. Instructional support and implementation structure during elementary teachers' science education simulation use

    Science.gov (United States)

    Gonczi, Amanda L.; Chiu, Jennifer L.; Maeng, Jennifer L.; Bell, Randy L.

    2016-07-01

    This investigation sought to identify patterns in elementary science teachers' computer simulation use, particularly implementation structures and instructional supports commonly employed by teachers. Data included video-recorded science lessons of 96 elementary teachers who used computer simulations in one or more science lessons. Results indicated teachers used a one-to-one student-to-computer ratio most often either during class-wide individual computer use or during a rotating station structure. Worksheets, general support, and peer collaboration were the most common forms of instructional support. The least common instructional support forms included lesson pacing, initial play, and a closure discussion. Students' simulation use was supported in the fewest ways during a rotating station structure. Results suggest that simulation professional development with elementary teachers needs to explicitly focus on implementation structures and instructional support to enhance participants' pedagogical knowledge and improve instructional simulation use. In addition, research is needed to provide theoretical explanations for the observed patterns that should subsequently be addressed in supporting teachers' instructional simulation use during professional development or in teacher preparation programs.

  16. Probabilistic Structural Analysis Methods (PSAM) for select space propulsion system structural components

    Science.gov (United States)

    Cruse, T. A.

    1987-01-01

    The objective is the development of several modular structural analysis packages capable of predicting the probabilistic response distribution for key structural variables such as maximum stress, natural frequencies, transient response, etc. The structural analysis packages are to include stochastic modeling of loads, material properties, geometry (tolerances), and boundary conditions. The solution is to be in terms of the cumulative probability of exceedance distribution (CDF) and confidence bounds. Two methods of probability modeling are to be included as well as three types of structural models - probabilistic finite-element method (PFEM); probabilistic approximate analysis methods (PAAM); and probabilistic boundary element methods (PBEM). The purpose in doing probabilistic structural analysis is to provide the designer with a more realistic ability to assess the importance of uncertainty in the response of a high performance structure. Probabilistic Structural Analysis Method (PSAM) tools will estimate structural safety and reliability, while providing the engineer with information on the confidence that should be given to the predicted behavior. Perhaps most critically, the PSAM results will directly provide information on the sensitivity of the design response to those variables which are seen to be uncertain.

  17. Probabilistic Structural Analysis Methods for select space propulsion system structural components (PSAM)

    Science.gov (United States)

    Cruse, T. A.; Burnside, O. H.; Wu, Y.-T.; Polch, E. Z.; Dias, J. B.

    1988-01-01

    The objective is the development of several modular structural analysis packages capable of predicting the probabilistic response distribution for key structural variables such as maximum stress, natural frequencies, transient response, etc. The structural analysis packages are to include stochastic modeling of loads, material properties, geometry (tolerances), and boundary conditions. The solution is to be in terms of the cumulative probability of exceedance distribution (CDF) and confidence bounds. Two methods of probability modeling are to be included as well as three types of structural models - probabilistic finite-element method (PFEM); probabilistic approximate analysis methods (PAAM); and probabilistic boundary element methods (PBEM). The purpose in doing probabilistic structural analysis is to provide the designer with a more realistic ability to assess the importance of uncertainty in the response of a high performance structure. Probabilistic Structural Analysis Method (PSAM) tools will estimate structural safety and reliability, while providing the engineer with information on the confidence that should be given to the predicted behavior. Perhaps most critically, the PSAM results will directly provide information on the sensitivity of the design response to those variables which are seen to be uncertain.

  18. Selectivity in ligand binding to uranyl compounds: A synthetic, structural, thermodynamic and computational study

    Energy Technology Data Exchange (ETDEWEB)

    Arnold, John [Univ. of California, Berkeley, CA (United States)

    2015-01-21

    The uranyl cation (UO₂²⁺) is the most abundant form of uranium on the planet. It is estimated that 4.5 billion tons of uranium in this form exist in sea water. The ability to bind and extract the uranyl cation from aqueous solution while separating it from other elements would provide a limitless source of nuclear fuel. A large body of research concerns the selective recognition and extraction of uranyl. A stable molecule, the cation has a linear O=U=O geometry. The short U-O bonds (1.78 Å) arise from the combination of uranium 5f/6d and oxygen 2p orbitals. Due to the oxygen moieties being multiply bonded, these sites were not thought to be basic enough for Lewis acidic coordination to be a viable approach to sequestration. The goal of this research is thus to broaden the coordination chemistry of the uranyl ion by studying new ligand systems via synthetic, structural, thermodynamic and computational methods. It is anticipated that this fundamental science will find use beyond actinide separation technologies in areas such as nuclear waste remediation and nuclear materials. The focus of this study is to synthesize uranyl complexes incorporating amidinate and guanidinate ligands. Both synthetic and computational methods are used to investigate novel equatorial ligand coordination and how this affects the basicity of the oxo ligands. Such an understanding will later apply to designing ligands incorporating functionalities that can bind uranyl both equatorially and axially for highly selective sequestration. Efficient and durable chromatography supports for lanthanide separation will be generated by (1) identifying robust peptoid-based ligands capable of binding different lanthanides with variable affinities, and (2) developing practical synthetic methods for the attachment of these ligands to Dowex ion exchange resins.

  19. Selectivity in ligand binding to uranyl compounds: A synthetic, structural, thermodynamic and computational study

    International Nuclear Information System (INIS)

    Arnold, John

    2015-01-01

    The uranyl cation (UO 2 2+ ) is the most abundant form of uranium on the planet. It is estimated that 4.5 billion tons of uranium in this form exist in sea water. The ability to bind and extract the uranyl cation from aqueous solution while separating it from other elements would provide a limitless source of nuclear fuel. A large body of research concerns the selective recognition and extraction of uranyl. A stable molecule, the cation has a linear O=U=O geometry. The short U-O bonds (1.78 Å) arise from the combination of uranium 5f/6d and oxygen 2p orbitals. Due to the oxygen moieties being multiply bonded, these sites were not thought to be basic enough for Lewis acidic coordination to be a viable approach to sequestration. The goal of this research is thus to broaden the coordination chemistry of the uranyl ion by studying new ligand systems via synthetic, structural, thermodynamic and computational methods. It is anticipated that this fundamental science will find use beyond actinide separation technologies in areas such as nuclear waste remediation and nuclear materials. The focus of this study is to synthesize uranyl complexes incorporating amidinate and guanidinate ligands. Both synthetic and computational methods are used to investigate novel equatorial ligand coordination and how this affects the basicity of the oxo ligands. Such an understanding will later apply to designing ligands incorporating functionalities that can bind uranyl both equatorially and axially for highly selective sequestration. Efficient and durable chromatography supports for lanthanide separation will be generated by (1) identifying robust peptoid-based ligands capable of binding different lanthanides with variable affinities, and (2) developing practical synthetic methods for the attachment of these ligands to Dowex ion exchange resins.

  20. The gender gap in student engagement: The role of teachers' autonomy support, structure, and involvement.

    Science.gov (United States)

    Lietaert, Sofie; Roorda, Debora; Laevers, Ferre; Verschueren, Karine; De Fraine, Bieke

    2015-12-01

    The gender gap in education in favour of girls is a widely known phenomenon. Boys generally have higher dropout rates, obtain lower grades, and show lower engagement. Insight into factors related to these academic outcomes could help to address the gender gap. This study investigated, for Dutch language classes, (1) how boys and girls differ in behavioural engagement, (2) which teacher support dimensions (autonomy support, structure, involvement) may explain gender differences in engagement (mediation hypothesis), and (3) whether and which of these teacher support dimensions matter more for boys' as opposed to girls' engagement (moderation or differential effects hypothesis). A total of 385 Grade 7 students and their 15 language teachers participated in this study. Teacher support was assessed through student reports. Student engagement was measured using student, teacher, and observer reports. By means of structural equation modelling, the mediating role of the teacher support dimensions for gender differences in behavioural engagement was tested. The potential differential role of the teacher support dimensions for boys' and girls' engagement was investigated through multigroup analysis. Boys were less engaged than girls and reported lower support from their teacher. Autonomy support and involvement partially mediated the relationship between gender and behavioural engagement. Autonomy support was demonstrated to be a protective factor for boys' engagement but not for girls'. Structure and involvement contributed equally to engagement for both sexes. Although involvement and autonomy support partly explained the gender gap in engagement (mediation hypothesis), more support was found for differential effects of autonomy support on boys' versus girls' engagement (differential effects hypothesis). © 2015 The British Psychological Society.

  1. A structural design of the multi-ringed seismic support for PCPV

    International Nuclear Information System (INIS)

    Muto, Kiyoshi; Ujiie, Koji.

    1979-01-01

    This report describes the multi-ringed cylindrical support newly developed as the supporting structure for a Prestressed Concrete Pressure Vessel. This support is composed of several thin cylinders of concentric circles, which are made of reinforced concrete or steel reinforced concrete. The characteristics of the support is such that it can allow two contradictory conditions to occur. That is, it can follow smoothly the radial displacement of PCPV induced by inner pressure, inner heat and etc. At the same time, it has enough rigidity to bear the earthquake forces from PCPV and to transmit them to the ground with certainty. The shape, characteristics and structural design of the support are described hereunder. (author)

  2. Selection and hydroponic growth of potato cultivars for bioregenerative life support systems

    Science.gov (United States)

    Molders, K.; Quinet, M.; Decat, J.; Secco, B.; Dulière, E.; Pieters, S.; van der Kooij, T.; Lutts, S.; Van Der Straeten, D.

    2012-07-01

    As part of the ESA-funded MELiSSA program, Ghent University and the Université catholique de Louvain investigated the suitability, growth and development of four potato cultivars in hydroponic culture under controlled conditions with the aim to incorporate such cultivation system in an Environmental Control and Life Support System (ECLSS). Potato plants can fulfill three major functions in an ECLSS in space missions: (a) fixation of CO2 and production of O2, (b) production of tubers for human nutrition and (c) production of clean water after condensation of the water vapor released from the plants by transpiration. Four cultivars (Annabelle, Bintje, Desiree and Innovator) were selected and grown hydroponically in nutrient film technique (NFT) gullies in a growth chamber under controlled conditions. The plant growth parameters, tuber harvest parameters and results of tuber nutritional analysis of the four cultivars were compared. The four potato cultivars grew well and all produced tubers. The growth period lasted 127 days for all cultivars except for Desiree which needed 145 days. Annabelle (1.45 kg/m2) and Bintje (1.355 kg/m2) were the best performing of the four cultivars. They also produced two times more tubers than Desiree and Innovator. Innovator produced the biggest tubers (20.95 g/tuber) and Desiree the smallest (7.67 g/tuber). The size of Annabelle and Bintje potatoes were intermediate. Bintje plants produced the highest total biomass in term of DW. The highest non-edible biomass was produced by Desiree, which showed both the highest shoot and root DW. The manual length and width measurements were also used to predict the total tuber mass. The energy values of the tubers remained in the range of the 2010 USDA and Souci-Fachmann-Kraut food composition databases. The amount of Ca determined was slightly reduced compared to the USDA value, but close to the Souci-Fachmann-Kraut value. The concentration of Cu, Zn and P were high compared to both databases

  3. IT vendor selection model by using structural equation model & analytical hierarchy process

    Science.gov (United States)

    Maitra, Sarit; Dominic, P. D. D.

    2012-11-01

    Selecting and evaluating the right vendors is imperative for an organization's global marketplace competitiveness. Improper selection and evaluation of potential vendors can dwarf an organization's supply chain performance. Numerous studies have demonstrated that firms consider multiple criteria when selecting key vendors. This research intends to develop a new hybrid model for vendor selection process with better decision making. The new proposed model provides a suitable tool for assisting decision makers and managers to make the right decisions and select the most suitable vendor. This paper proposes a Hybrid model based on Structural Equation Model (SEM) and Analytical Hierarchy Process (AHP) for long-term strategic vendor selection problems. The five steps framework of the model has been designed after the thorough literature study. The proposed hybrid model will be applied using a real life case study to assess its effectiveness. In addition, What-if analysis technique will be used for model validation purpose.

  4. Kin groups and trait groups: population structure and epidemic disease selection.

    Science.gov (United States)

    Fix, A G

    1984-10-01

    A Monte Carlo simulation based on the population structure of a small-scale human population, the Semai Senoi of Malaysia, has been developed to study the combined effects of group, kin, and individual selection. The population structure resembles D.S. Wilson's structured deme model in that local breeding populations (Semai settlements) are subdivided into trait groups (hamlets) that may be kin-structured and are not themselves demes. Additionally, settlement breeding populations are connected by two-dimensional stepping-stone migration approaching 30% per generation. Group and kin-structured group selection occur among hamlets the survivors of which then disperse to breed within the settlement population. Genetic drift is modeled by the process of hamlet formation; individual selection as a deterministic process, and stepping-stone migration as either random or kin-structured migrant groups. The mechanism for group selection is epidemics of infectious disease that can wipe out small hamlets particularly if most adults become sick and social life collapses. Genetic resistance to a disease is an individual attribute; however, hamlet groups with several resistant adults are less likely to disintegrate and experience high social mortality. A specific human gene, hemoglobin E, which confers resistance to malaria, is studied as an example of the process. The results of the simulations show that high genetic variance among hamlet groups may be generated by moderate degrees of kin-structuring. This strong microdifferentiation provides the potential for group selection. The effect of group selection in this case is rapid increase in gene frequencies among the total set of populations. In fact, group selection in concert with individual selection produced a faster rate of gene frequency increase among a set of 25 populations than the rate within a single unstructured population subject to deterministic individual selection. Such rapid evolution with plausible rates of

  5. Intragranular cellular segregation network structure strengthening 316L stainless steel prepared by selective laser melting

    Science.gov (United States)

    Zhong, Yuan; Liu, Leifeng; Wikman, Stefan; Cui, Daqing; Shen, Zhijian

    2016-03-01

    A feasibility study was performed to fabricate ITER In-Vessel components by Selective Laser Melting (SLM) supported by Fusion for Energy (F4E). Almost fully dense 316L stainless steel (SS316L) components were prepared from gas-atomized powder and with optimized SLM processing parameters. Tensile tests and Charpy-V tests were carried out at 22 °C and 250 °C and the results showed that SLM SS316L fulfill the RCC-MR code. Microstructure characterization reveals the presence of hierarchical macro-, micro- and nano-structures in as-built samples that were very different from SS316L microstructures prepared by other established methods. The formation of a characteristic intragranular cellular segregation network microstructure appears to contribute to the increase of yield strength without losing ductility. Silicon oxide nano-inclusions were formed during the SLM process that generated a micro-hardness fluctuation in the building direction. The combined influence of a cellular microstructure and the nano-inclusions constraints the size of ductile dimples to nano-scale. The crack propagation is hindered by a pinning effect that improves the defect-tolerance of the SLM SS316L. This work proves that it was possible to manufacture SS316L with properties suitable for ITER First Wall panels. Further studies on irradiation properties of SLM SS316L and manufacturing of larger real-size components are needed.

  6. Response spectra for differential motion of structures supports during earthquakes in Egypt

    Directory of Open Access Journals (Sweden)

    Mohamed I.S. Elmasry

    2012-12-01

    Full Text Available Differential motions of ground supports of stiff structures with large plan dimensions and separate foundations under earthquakes were studied by researchers during the last few decades. Such a type of structural response was previously underestimated. The importance of studying such a response comes up from the fact that usually the structures affected are of strategic importance such as bridges. During their expected life, structures may experience vibrations excited by ground waves of short wavelengths during near-source earthquakes, or during amplified earthquake signals, during explosions, or during vibrations induced from nearby strong vibration sources. This is the case when the differential motion of supports becomes considerable. This paper aims to review the effects of seismic signal variations along the structures dimensions with emphasis on Egypt as a case study. The paper shows some patterns of the damage imposed by such differential motion. A replication of the differential motion in the longitudinal direction is applied on a frame bridge model. The resulting straining actions show the necessity for considering the differential motion of supports in the design of special structures in Egypt. Finally, response spectra for the differential motion of supports, based on the available data from previous earthquakes in Egypt, is derived and proposed for designers to include in the design procedure when accounting for such type of structural response, and especially in long-span bridges.

  7. Design of the core support and restraint structures for FFTF and CRBRP

    International Nuclear Information System (INIS)

    Sutton, H.G.; Rylatt, J.A.

    1977-12-01

    This paper presents and compares the design and fabrication of the FFTF and CRBRP reactor structures which support and restrain the reactor core assemblies. The fabrication of the core support structure (CSS) for the FFTF reactor was completed October 1972 and this paper discusses how the fabrication problems encountered with the FFTF were avoided in the subsequent design of the CRBR CSS. The radial core restraint structure of the FFTF was designed and fabricated such that an active system could replace the present passive system which is segmented and relies on the CSS core barrel for total structure integrity to maintain core geometry. The CRBR core restraint structure is designed for passive restraint only, and this paper discusses how the combined strengths of the restraint structure former rings and the CSS core barrel are utilized to maintain core geometry. Whereas the CSS for the FFTF interfaces directly with the reactor core assemblies, the CRBR CSS does not. A comparison is made on how intermediate structures in CRBR (inlet modules) provide the necessary design interfaces for supporting and providing flow distribution to the reactor core assemblies. A discussion is given on how the CRBR CSS satisfied the design requirements of the Equipment Specification, including thermal transient, dynamic and seismic loadings, and results of flow distribution testing that supported the CRBR design effort. The approach taken to simplify fabrication of the CRBR components, and a novel 20 inch deep narrow gap weld joint in the CSS are described

  8. Selective Aerobic Oxidation of 5-Hydroxymethylfurfural in Water Over Solid Ruthenium Hydroxide Catalysts with Magnesium-Based Supports

    DEFF Research Database (Denmark)

    Gorbanev, Yury; Kegnæs, Søren; Riisager, Anders

    2011-01-01

    Solid catalyst systems comprised of ruthenium hydroxide supported on magnesium-based carrier materials (spinel, magnesium oxide and hydrotalcite) were investigated for the selective, aqueous aerobic oxidation of the biomass-derived chemical 5-hydroxymethylfurfural into 2,5-furandicarboxylic acid...

  9. Fine-tuning of electromembrane extraction selectivity using 18-crown-6 ethers as supported liquid membrane modifiers

    Czech Academy of Sciences Publication Activity Database

    Šlampová, Andrea; Kubáň, Pavel; Boček, Petr

    2014-01-01

    Roč. 35, č. 23 (2014), s. 3317-3320 ISSN 0173-0835 R&D Projects: GA ČR(CZ) GA13-05762S Institutional support: RVO:68081715 Keywords : 18-Crown-6 ethers * electromembrane extraction * inorganic cations * selectivity modification Subject RIV: CB - Analytical Chemistry, Separation Impact factor: 3.028, year: 2014

  10. Application of AHP method for optimal selection of the IT system supporting business operations in the logistics enterprise

    Directory of Open Access Journals (Sweden)

    Anna Baj-Rogowska

    2015-12-01

    The paper consists of three parts. The first one includes an overview of IT systems supporting the logistics management in a company. Then a theoretical background of the Analytic Hierarchy Process is presented as the basis for deliberations contained in the third part, which offers a way to solve the problem of IT system selection that can be used by any logistics company.

  11. LIQUID PHASE SELECTIVE OXIDATION OF ETHYLBENZENE OVER ACTIVATED AL2O3 SUPPORTED V2O5 CATALYST

    Science.gov (United States)

    Acetophenone, a very useful industrial chemical for fragrance and flavoring agent and a solvent for plastics and resins, is usually produced as a byproduct of phenol production from cumeme. Aluminia supported vandium oxide catalyst is now explored for the selective oxidation of e...

  12. Analysis of an Interactive Technology Supported Problem-Based Learning STEM Project Using Selected Learning Sciences Interest Areas (SLSIA)

    Science.gov (United States)

    Kumar, David Devraj

    2017-01-01

    This paper reports an analysis of an interactive technology-supported, problem-based learning (PBL) project in science, technology, engineering and mathematics (STEM) from a Learning Sciences perspective using the Selected Learning Sciences Interest Areas (SLSIA). The SLSIA was adapted from the "What kinds of topics do ISLS [International…

  13. Selected Aircraft Throttle Controller With Support Of Fuzzy Expert Inference System

    Directory of Open Access Journals (Sweden)

    Żurek Józef

    2014-12-01

    Full Text Available The paper describes Zlin 143Lsi aircraft engine work parameters control support method – hourly fuel flow as a main factor under consideration. The method concerns project of aircraft throttle control support system with use of fuzzy logic (fuzzy inference. The primary purpose of the system is aircraft performance optimization, reducing flight cost at the same time and support proper aircraft engine maintenance. Matlab Software and Fuzzy Logic Toolbox were used in the project. Work of the system is presented with use of twenty test samples, five of them are presented graphically. In addition, system control surface, included in the paper, supports system all work range analysis.

  14. Investigation on Mechanical Properties’ Anisotropy of Rod Units in Lattice Structures Fabricated by Selective Laser Melting

    Directory of Open Access Journals (Sweden)

    Jing Chenchen

    2017-01-01

    Full Text Available Lattice structure with high strength and low mass using selective laser melting (SLM has been a hot topic. However, there are some problems in the fabrication of lattice structure by SLM. Rod unit is the basic component of lattice structure and its performance affects the whole structure. It is necessary to investigate the influence of selective laser melting on rod unit’s mechanical properties. A series of rod units with different inclination angle and diameter were fabricated by SLM in this research. And the mechanical properties of these units were measured by tensile test. The results show that the rod units with different diameters and inclination angles have good mechanical properties and show no difference. It is a good news for lattice structure designing for there is no necessary to consider the mechanical properties’ anisotropy of rod units.

  15. IMPROVEMENT OF THE SUPPORTING STRUCTURE OF PLATFORM CAR FOR HIGHER EFFICIENCY OF CONTAINER TRANSPORTATIONS

    Directory of Open Access Journals (Sweden)

    A. O. Lovska

    2017-02-01

    Full Text Available Purpose. The article is aimed to improve supporting structures of the platform car to increase the efficiency of container transportations. Methodology. In order to achieve the objective, the strength investigations of the universal platform car of the model 13-401 were conducted, strength reserves of the supporting elements were defined, and more optimal profiles of basic longitudinal beams of the frame in terms of the minimum material capacity were proposed. Decision correctness was confirmed by the strength calculation of the platform car supporting structure at basic loading operational modes and fatigue taking into account the research database of 107 cycles. It has been proposed to equip a platform car with swing fitting stops for fastening containers on the frame, which allows transportation of 20ft and 40ft containers. In order to improve container transportation efficiency along international transport corridors running through Ukraine, a platform car of articulated type has been designed on the base of the improved platform car structure. The mathematical simulation of dynamic loads of the platform car with containers (two 1CC containers at operational loading modes has been carried out, the maximum accelerations influencing the support structure have been defined, and their multiple values have been considered in computer simulation of the strength of the platform car of articulated type. Findings. The support structure of the platform car of articulated type on the basis of the standard platform car has been developed. Refined values of dynamic loads influencing supporting structure the platform car of articulated type with containers at operational loading modes have been obtained; the maximum equivalent stresses in the platform car support structure have been defined. Originality and practical value. A mathematical model of displacements for a platform car of articulated type with containers at operational loading modes of

  16. Factor Structure and Measurement Invariance of the Need-Supportive Teaching Style Scale for Physical Education.

    Science.gov (United States)

    Liu, Jing-Dong; Chung, Pak-Kwong

    2017-08-01

    The purpose of the current study was to examine the factor structure and measurement invariance of a scale measuring students' perceptions of need-supportive teaching (Need-Supportive Teaching Style Scale in Physical Education; NSTSSPE). We sampled 615 secondary school students in Hong Kong, 200 of whom also completed a follow-up assessment two months later. Factor structure of the scale was examined through exploratory structural equation modeling (ESEM). Further, nomological validity of the NSTSSPE was evaluated by examining the relationships between need-supportive teaching style and student satisfaction of psychological needs. Finally, four measurement models-configural, metric invariance, scalar invariance, and item uniqueness invariance-were assessed using multiple group ESEM to test the measurement invariance of the scale across gender, grade, and time. ESEM results suggested a three-factor structure of the NSTSSPE. Nomological validity was supported, and weak, strong, and strict measurement invariance of the NSTSSPE was evidenced across gender, grade, and time. The current study provides initial psychometric support for the NSTSSPE to assess student perceptions of teachers' need-supportive teaching style in physical education classes.

  17. Structural analysis of vacuum vessel and blanket support system for International Thermonuclear Experimental Reactor (ITER)

    International Nuclear Information System (INIS)

    Kitamura, Kazunori; Koizumi, Kouichi; Takatsu, Hideyuki; Tada, Eisuke; Shimane, Hideo.

    1996-11-01

    Structural analyses of vacuum vessel and blanket support system have been performed to examine their integrated structural behavior under the design loads and to assess their structural feasibility, with two kinds of three-dimensional (3-D) FEM models; a detailed model with 18deg sector region to investigate the detailed mechanical behaviors of the blanket and vessel components under the several symmetric loads, and a 180deg torus model with relatively coarser meshes to assess the structural responses under the asymmetric VDE load. The analytical results obtained by both models were also compared for the several symmetric loads to check the equivalent mechanical stiffness of the 180deg torus model. As the results, most of the vessel and blanket components have sufficient mechanical integrities with the stress level below the allowable limit of the materials, while the lower parts of inboard/outboard back plate need to be reinforced by increasing the thickness and/or mounting a toroidal ring support at the lower edge of the back plate. Two types of eigenvalue analyses were also conducted with the 180deg torus model to investigate natural frequencies of the vessel torus support system and to assess the mechanical integrity of the elastic stability under the asymmetric VDE load. Analytical results show that the mechanical stiffness of the vessel gravity support should be higher in the view point of a seismic response, and that those of the blanket support structures should also be increased for the buckling strength against the VDE vertical force. (author)

  18. Evaluation of the Impact of the EU Structural Support on the Competitiveness of Lithuanian Economics

    Directory of Open Access Journals (Sweden)

    Rita Remeikiene

    2016-06-01

    Full Text Available Increasing amounts of the EU structural support in Lithuania require theoretical and practical research to disclose the determinants that have a significant impact on the competitiveness of Lithuanian economics. The purpose of this article is to evaluate the impact of the EU structural support on the competitiveness of Lithuanian economics. The methods of the research include systematic and comparative analysis of the scientific literature, expert evaluation and linear regression. The research disclosed the main determinants of country’s competitiveness. The results have revealed that EU structural support has the most significant impact on Lithuanian engineering and technological infrastructure. The impact of the support on country’s macroeconomic, scientific and social environment can also be considered as significant. The EU structural support has medium strong impact on education and business environment conditions in Lithuania. It has been established that, in the field of business advancement, Lithuanian should be rated as medium competitive. Hence, the increase in country’s competitiveness by employing EU structural funds should be treated as one of priority aims. In addition, responsible authorities should perform with higher efficiency seeking for higher competitiveness of the country.

  19. Selecting Relevant Information for Medical Decision Support with Application in Cardiology

    Czech Academy of Sciences Publication Activity Database

    Kalina, Jan; Seidl, L.; Grünfeldová, H.; Slovák, Dalibor; Zvárová, Jana

    2013-01-01

    Roč. 9, č. 1 (2013), s. 2-6 ISSN 1801-5603 R&D Projects: GA MŠk(CZ) 1M06014 Institutional support: RVO:67985807 Keywords : decision support system * web-service * information extraction * high dimension * gene expressions Subject RIV: IN - Informatics, Computer Science http://www.ejbi.org/img/ejbi/2013/1/Kalina_en.pdf

  20. Plasticity of the Binding Site of Renin: Optimized Selection of Protein Structures for Ensemble Docking.

    Science.gov (United States)

    Strecker, Claas; Meyer, Bernd

    2018-05-02

    Protein flexibility poses a major challenge to docking of potential ligands in that the binding site can adopt different shapes. Docking algorithms usually keep the protein rigid and only allow the ligand to be treated as flexible. However, a wrong assessment of the shape of the binding pocket can prevent a ligand from adapting a correct pose. Ensemble docking is a simple yet promising method to solve this problem: Ligands are docked into multiple structures, and the results are subsequently merged. Selection of protein structures is a significant factor for this approach. In this work we perform a comprehensive and comparative study evaluating the impact of structure selection on ensemble docking. We perform ensemble docking with several crystal structures and with structures derived from molecular dynamics simulations of renin, an attractive target for antihypertensive drugs. Here, 500 ns of MD simulations revealed binding site shapes not found in any available crystal structure. We evaluate the importance of structure selection for ensemble docking by comparing binding pose prediction, ability to rank actives above nonactives (screening utility), and scoring accuracy. As a result, for ensemble definition k-means clustering appears to be better suited than hierarchical clustering with average linkage. The best performing ensemble consists of four crystal structures and is able to reproduce the native ligand poses better than any individual crystal structure. Moreover this ensemble outperforms 88% of all individual crystal structures in terms of screening utility as well as scoring accuracy. Similarly, ensembles of MD-derived structures perform on average better than 75% of any individual crystal structure in terms of scoring accuracy at all inspected ensembles sizes.

  1. Ultrasonic imaging of tube/support structure of power plant steam generators

    International Nuclear Information System (INIS)

    Saniie, J.; Nagle, D.T.

    1987-01-01

    The corrosion and erosion of steam generator tubing in nuclear power plants can present problems of both safety and economics. In steam generators, the inconel tubes are fit loosely through holes drilled in carbon steel support plates. Corrosion is of particular concern with such tube/support plate structures. Non-protective magnetite can build up on the inner surface of the support plate holes, and allowed to continue unchecked, will fill the gap, eventually denting and fracturing the tube walls. Therefore, periodic nondestructive inspection can be valuable in characterizing corrosion and can be used in evaluating the effectiveness of chemical treatments used to control or reduce corrosion. Presently, they are investigating the feasibility and practicality of using ultrasound in routing testing for gap measurement, for evaluating the corrosion and assessing the degree of denting. The tube/support structure can be modeled as a multilayer, reverberant target, which when tested with ultrasound results in two sets of reverberating echoes [1]. One set corresponds to the tube wall and the other to the support plate. These echoes must be decomposed and identified in order to evaluate the tube/support structure. This report presents experimental results along with a discussion of various measurements and processing techniques for decomposing and interpreting tube/support echoes at different stages of corrosion

  2. 3D Bearing Capacity of Structured Cells Supported on Cohesive Soil: Simplified Analysis Method

    Directory of Open Access Journals (Sweden)

    Martínez-Galván Sergio Antonio

    2013-06-01

    Full Text Available In this paper a simplified analysis method to compute the bearing capacity of structured cell foundations subjected to vertical loading and supported in soft cohesive soil is proposed. A structured cell is comprised by a top concrete slab structurally connected to concrete external walls that enclose the natural soil. Contrary to a box foundation it does not include a bottom slab and hence, the soil within the walls becomes an important component of the structured cell. This simplified method considers the three-dimensional geometry of the cell, the undrained shear strength of cohesive soils and the existence of structural continuity between the top concrete slab and the surrounding walls, along the walls themselves and the walls structural joints. The method was developed from results of numerical-parametric analyses, from which it was found that structured cells fail according to a punching-type mechanism.

  3. Population structure and strong divergent selection shape phenotypic diversification in maize landraces.

    Science.gov (United States)

    Pressoir, G; Berthaud, J

    2004-02-01

    To conserve the long-term selection potential of maize, it is necessary to investigate past and present evolutionary processes that have shaped quantitative trait variation. Understanding the dynamics of quantitative trait evolution is crucial to future crop breeding. We characterized population differentiation of maize landraces from the State of Oaxaca, Mexico for quantitative traits and molecular markers. Qst values were much higher than Fst values obtained for molecular markers. While low values of Fst (0.011 within-village and 0.003 among-villages) suggest that considerable gene flow occurred among the studied populations, high levels of population differentiation for quantitative traits were observed (ie an among-village Qst value of 0.535 for kernel weight). Our results suggest that although quantitative traits appear to be under strong divergent selection, a considerable amount of gene flow occurs among populations. Furthermore, we characterized nonproportional changes in the G matrix structure both within and among villages that are consequences of farmer selection. As a consequence of these differences in the G matrix structure, the response to multivariate selection will be different from one population to another. Large changes in the G matrix structure could indicate that farmers select for genes of major and pleiotropic effect. Farmers' decision and selection strategies have a great impact on phenotypic diversification in maize landraces.

  4. Structural insights into human peroxisome proliferator activated receptor delta (PPAR-delta selective ligand binding.

    Directory of Open Access Journals (Sweden)

    Fernanda A H Batista

    Full Text Available Peroxisome proliferator activated receptors (PPARs δ, α and γ are closely related transcription factors that exert distinct effects on fatty acid and glucose metabolism, cardiac disease, inflammatory response and other processes. Several groups developed PPAR subtype specific modulators to trigger desirable effects of particular PPARs without harmful side effects associated with activation of other subtypes. Presently, however, many compounds that bind to one of the PPARs cross-react with others and rational strategies to obtain highly selective PPAR modulators are far from clear. GW0742 is a synthetic ligand that binds PPARδ more than 300-fold more tightly than PPARα or PPARγ but the structural basis of PPARδ:GW0742 interactions and reasons for strong selectivity are not clear. Here we report the crystal structure of the PPARδ:GW0742 complex. Comparisons of the PPARδ:GW0742 complex with published structures of PPARs in complex with α and γ selective agonists and pan agonists suggests that two residues (Val312 and Ile328 in the buried hormone binding pocket play special roles in PPARδ selective binding and experimental and computational analysis of effects of mutations in these residues confirms this and suggests that bulky substituents that line the PPARα and γ ligand binding pockets as structural barriers for GW0742 binding. This analysis suggests general strategies for selective PPARδ ligand design.

  5. Multi-atlas pancreas segmentation: Atlas selection based on vessel structure.

    Science.gov (United States)

    Karasawa, Ken'ichi; Oda, Masahiro; Kitasaka, Takayuki; Misawa, Kazunari; Fujiwara, Michitaka; Chu, Chengwen; Zheng, Guoyan; Rueckert, Daniel; Mori, Kensaku

    2017-07-01

    Automated organ segmentation from medical images is an indispensable component for clinical applications such as computer-aided diagnosis (CAD) and computer-assisted surgery (CAS). We utilize a multi-atlas segmentation scheme, which has recently been used in different approaches in the literature to achieve more accurate and robust segmentation of anatomical structures in computed tomography (CT) volume data. Among abdominal organs, the pancreas has large inter-patient variability in its position, size and shape. Moreover, the CT intensity of the pancreas closely resembles adjacent tissues, rendering its segmentation a challenging task. Due to this, conventional intensity-based atlas selection for pancreas segmentation often fails to select atlases that are similar in pancreas position and shape to those of the unlabeled target volume. In this paper, we propose a new atlas selection strategy based on vessel structure around the pancreatic tissue and demonstrate its application to a multi-atlas pancreas segmentation. Our method utilizes vessel structure around the pancreas to select atlases with high pancreatic resemblance to the unlabeled volume. Also, we investigate two types of applications of the vessel structure information to the atlas selection. Our segmentations were evaluated on 150 abdominal contrast-enhanced CT volumes. The experimental results showed that our approach can segment the pancreas with an average Jaccard index of 66.3% and an average Dice overlap coefficient of 78.5%. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Research and Design of Fixed Photovoltaic Support Structure Based on SAP2000

    Directory of Open Access Journals (Sweden)

    Wang Xingxing

    2018-01-01

    Full Text Available In the solar photovoltaic power station project, PV support is one of the main structures, and fixed photovoltaic PV support is one of the most commonly used stents. For the the actual demand in a Japanese photovoltaic power, SAP2000 finite element analysis software is used in this paper, based on Japanese Industrial Standard (JIS C 8955-2011, describing the system of fixed photovoltaic support structure design and calculation method and process. The results show that: (1 according to the general requirements of 4 rows and 5 columns fixed photovoltaic support, the typical permanent load of the PV support is 4679.4 N, the wind load being 1.05 kN/m2, the snow load being 0.89 kN/m2 and the seismic load is 5877.51 N; (2 by theoretical calculation of the two ends extended beam model, the beam span under the rail is determined 2200 mm; (3 by the way of using the single factor experiment, through the calculation and analysis of SAP2000, the three best supporting points of the support of the W stent are determined; (4 by comprehensive simulation, the optimal parameters for the rail, beam, support and bolt are 60× 60× 1.0, 60× 60× 1.0, 40× 50× 2.0, and M10 respectively.

  7. Highly selective hydrogenation of furfural to furfuryl alcohol over Pt nanoparticles supported on g-C3N4 nanosheets catalysts in water

    OpenAIRE

    Chen, Xiufang; Zhang, Ligang; Zhang, Bo; Guo, Xingcui; Mu, Xindong

    2016-01-01

    Graphitic carbon nitride nanosheets were investigated for developing effective Pt catalyst supports for selective hydrogenation of furfural to furfuryl alcohol in water. The nanosheets with an average thickness of about 3 nm were synthesized by a simple and green method through thermal oxidation etching of bulk g-C3N4 in air. Combined with the unique feature of nitrogen richness and locally conjugated structure, the g-C3N4 nanosheets with a high surface area of 142?m2 g?1 were demonstrated to...

  8. Conceptual Design of a Floating Support Structure and Mooring System for a Vertical Axis Wind Turbine

    DEFF Research Database (Denmark)

    Berthelsen, Petter Andreas; Fylling, Ivar; Vita, Luca

    2012-01-01

    This paper deals with the conceptual design of a floating support structure and mooring system for a 5MW vertical axis offshore wind turbine. The work is carried out as part of the DeepWind project, where the main objective is to investigate the feasibility of a floating vertical axis offshore wind...... turbine. The DeepWind concept consists of a Darrieus rotor mounted on a spar buoy support structure. The conceptual design is carried out in an iterative process, involving the different subcomponents. The present work is part of the first design iteration and the objective is to find a feasible floating...... support structure and mooring system for the DeepWind concept. The conceptual design is formulated as an optimization problem: Starting with an initial configuration, the optimization procedure tries to find a cheaper solution while satisfying a set of design requirements. This approach utilizes available...

  9. Plasma turbulence. Structure formation, selection rule, dynamic response and dynamics transport

    International Nuclear Information System (INIS)

    Ito, Sanae I.

    2010-01-01

    The five-year project of Grant-in-Aid for Specially Promoted Research entitled general research on the structure formation and selection rule in plasma turbulence had brought many outcomes. Based on these outcomes, the Grant-in-Aid for Scientific Research (S) program entitled general research on dynamic response and dynamic transport in plasma turbulence has started. In the present paper, the state-of-the-art of the research activities on the structure formation, selection rule and dynamics in plasma turbulence are reviewed with reference to outcomes of these projects. (author)

  10. Seismic response analysis of structural system subjected to multiple support excitation

    International Nuclear Information System (INIS)

    Wu, R.W.; Hussain, F.A.; Liu, L.K.

    1978-01-01

    In the seismic analysis of a multiply supported structural system subjected to nonuniform excitations at each support point, the single response spectrum, the time history, and the multiple response spectrum are the three commonly employed methods. In the present paper the three methods are developed, evaluated, and the limitations and advantages of each method assessed. A numerical example has been carried out for a typical piping system. Considerably smaller responses have been predicted by the time history method than that by the single response spectrum method. This is mainly due to the fact that the phase and amplitude relations between the support excitations are faithfully retained in the time history method. The multiple response spectrum prediction has been observed to compare favourably with the time history method prediction. Based on the present evaluation, the multiple response spectrum method is the most efficient method for seismic response analysis of structural systems subjected to multiple support excitation. (Auth.)

  11. MATHEMATICAL AND INFORMATION SUPPORT FOR CALCULATION AND DESIGN OF TUBE GAS HEATERS LOCATED IN STRUCTURES

    Directory of Open Access Journals (Sweden)

    CHORNOMORETS H. Y.

    2016-02-01

    Full Text Available Raising of problem. For the design and construction of tube gas heaters in building structures to need solve the problems of analysis and synthesis of such heating system. The mathematical model of this system is consists of: mathematical model of the tube gas heater, mathematical model of heat distribution in the building structure and corresponding boundary conditions. To solve the tasks of analysis and synthesis must be appropriate mathematical and information support. Purpose. The purpose of this paper is to describe the developed mathematical and information support that solve the problems of analysis and synthesis of heating systems with gas tube heaters, located in building constructions.Conclusion. Mathematical support includes the development of algorithms and software for the numerical solution of problems analysis and synthesis heating system. Information support includes all the necessary parameters characterizing the thermal properties of materials which used in the heating system, and the parameters characterizing the heat exchange between the coolant and components of the heating system. It was developed algorithms for solving problems of analysis and synthesis heating system with tube gas heater located in structures to use evolutionary search algorithm and software. It was made experimental study and was obtained results allow to calculate the heat transfer from the gas-air mixture to the boundary surface of the building structure. This results and computation will provide full information support for solving problems of analysis and synthesis of the heating system. Was developed mathematical and software support, which allows to solve the problems of analysis and synthesis heating systems with gas tube heaters, located in building structures. Tube gas heaters located in the building structures allows with small capital expenditures to provide space heating. Is necessary to solve the problems of analysis (calculation and

  12. The Ecological Dynamics of Natural Selection: Traits and the Coevolution of Community Structure.

    Science.gov (United States)

    McPeek, Mark A

    2017-05-01

    Natural selection has both genetic and ecological dynamics. The fitnesses of individuals change with their ecological context, and so the form and strength of selective agents change with abiotic factors and the phenotypes and abundances of interacting species. I use standard models of consumer-resource interactions to explore the ecological dynamics of natural selection and how various trait types influence these dynamics and the resulting structure of a community of coevolving species. Evolutionary optima favored by natural selection depend critically on the abundances of interacting species, and the traits of species can undergo dynamic cycling in limited areas of parameter space. The ecological dynamics of natural selection can also drive shifts from one adaptive peak to another, and these ecologically driven adaptive peak shifts are fundamental to the dynamics of niche differentiation. Moreover, this ecological differentiation is fostered in more productive and more benign environments where species interactions are stronger and where the selection gradients generated by species interactions are stronger. Finally, community structure resulting from coevolution depends fundamentally on the types of traits that underlie species interactions. The ecological dynamics of the process cannot be simplified, neglected, or ignored if we are to build a predictive theory of natural selection.

  13. Space-planning and structural solutions of low-rise buildings: Optimal selection methods

    Science.gov (United States)

    Gusakova, Natalya; Minaev, Nikolay; Filushina, Kristina; Dobrynina, Olga; Gusakov, Alexander

    2017-11-01

    The present study is devoted to elaboration of methodology used to select appropriately the space-planning and structural solutions in low-rise buildings. Objective of the study is working out the system of criteria influencing the selection of space-planning and structural solutions which are most suitable for low-rise buildings and structures. Application of the defined criteria in practice aim to enhance the efficiency of capital investments, energy and resource saving, create comfortable conditions for the population considering climatic zoning of the construction site. Developments of the project can be applied while implementing investment-construction projects of low-rise housing at different kinds of territories based on the local building materials. The system of criteria influencing the optimal selection of space-planning and structural solutions of low-rise buildings has been developed. Methodological basis has been also elaborated to assess optimal selection of space-planning and structural solutions of low-rise buildings satisfying the requirements of energy-efficiency, comfort and safety, and economical efficiency. Elaborated methodology enables to intensify the processes of low-rise construction development for different types of territories taking into account climatic zoning of the construction site. Stimulation of low-rise construction processes should be based on the system of approaches which are scientifically justified; thus it allows enhancing energy efficiency, comfort, safety and economical effectiveness of low-rise buildings.

  14. Three-dimensional structure of Au nanoparticles supported on amorphous silica and carbon substrates

    International Nuclear Information System (INIS)

    Bruma, A; Li, Z Y

    2012-01-01

    Scanning Transmission Electron Microscope (STEM) has been employed to study the three-dimensional structure of gold (Au) nanoparticles deposited by means of thermal evaporation in high vacuum on amorphous silica (a-SiO 2 ) and amorphous carbon (a-C) supports. By performing quantitative analysis on the evolution of the high angle annular dark field (HAADF) images, we studied the influence of the nature and the temperature of support on the growth mode of gold nanoparticles.

  15. Selective alkane activation with single-site atoms on amorphous support

    Science.gov (United States)

    Hock, Adam S.; Schweitzer, Neil M.; Miller, Jeffrey T.; Hu, Bo

    2015-11-24

    The present invention relates generally to catalysts and methods for use in olefin production. More particularly, the present invention relates to novel amorphously supported single-center, Lewis acid metal ions and use of the same as catalysts.

  16. Temporally selective attention supports speech processing in 3- to 5-year-old children.

    Science.gov (United States)

    Astheimer, Lori B; Sanders, Lisa D

    2012-01-01

    Recent event-related potential (ERP) evidence demonstrates that adults employ temporally selective attention to preferentially process the initial portions of words in continuous speech. Doing so is an effective listening strategy since word-initial segments are highly informative. Although the development of this process remains unexplored, directing attention to word onsets may be important for speech processing in young children who would otherwise be overwhelmed by the rapidly changing acoustic signals that constitute speech. We examined the use of temporally selective attention in 3- to 5-year-old children listening to stories by comparing ERPs elicited by attention probes presented at four acoustically matched times relative to word onsets: concurrently with a word onset, 100 ms before, 100 ms after, and at random control times. By 80 ms, probes presented at and after word onsets elicited a larger negativity than probes presented before word onsets or at control times. The latency and distribution of this effect is similar to temporally and spatially selective attention effects measured in adults and, despite differences in polarity, spatially selective attention effects measured in children. These results indicate that, like adults, preschool aged children modulate temporally selective attention to preferentially process the initial portions of words in continuous speech. Copyright © 2011 Elsevier Ltd. All rights reserved.

  17. Supported sub-nanometer Ta oxide clusters as model catalysts for the selective epoxidation of cyclooctene

    KAUST Repository

    Zwaschka, Gregor; Rondelli, Manuel; Krause, Maximilian; Rö tzer, Marian David; Hedhili, Mohamed N.; Heiz, Ulrich; Basset, Jean-Marie; Schweinberger, Florian; D'Elia, Valerio

    2018-01-01

    The preparation of organic ligands-free, isolated tantalum oxide atoms (Ta1) and small clusters (Tan>1) on flat silicate supports was accomplished by ultra-high vacuum (UHV) techniques followed by oxidation in air. The resulting surface complexes were thoroughly characterized and tested as supported catalysts for the epoxidation of cycloalkenes. The observed catalytic performance highlights the potential of the applied method for the production of active catalysts and the study of well-defined, ligand-free metal oxide moieties.

  18. Supported sub-nanometer Ta oxide clusters as model catalysts for the selective epoxidation of cyclooctene

    KAUST Repository

    Zwaschka, Gregor

    2018-01-22

    The preparation of organic ligands-free, isolated tantalum oxide atoms (Ta1) and small clusters (Tan>1) on flat silicate supports was accomplished by ultra-high vacuum (UHV) techniques followed by oxidation in air. The resulting surface complexes were thoroughly characterized and tested as supported catalysts for the epoxidation of cycloalkenes. The observed catalytic performance highlights the potential of the applied method for the production of active catalysts and the study of well-defined, ligand-free metal oxide moieties.

  19. Structural Stability of Light-harvesting Protein LH2 Adsorbed on Mesoporous Silica Supports.

    Science.gov (United States)

    Shibuya, Yuuta; Itoh, Tetsuji; Matsuura, Shun-ichi; Yamaguchi, Akira

    2015-01-01

    In the present study, we examined the reversible thermal deformation of the membrane protein light-harvesting complex LH2 adsorbed on mesoporous silica (MPS) supports. The LH2 complex from Thermochromatium tepidum cells was conjugated to MPS supports with a series of pore diameter (2.4 to 10.6 nm), and absorption spectra of the resulting LH2/MPS conjugates were observed over a temperature range of 273 - 313 K in order to examine the structure of the LH2 adsorbed on the MPS support. The experimental results confirmed that a slight ellipsoidal deformation of LH2 was induced by adsorption on the MPS supports. On the other hand, the structural stability of LH2 was not perturbed by the adsorption. Since the pore diameter of MPS support did not influence the structural stability of LH2, it could be considered that the spatial confinement of LH2 in size-matches pore did not improve the structural stability of LH2.

  20. Polarization Selectivity of Artificial Anisotropic Structures Based on DNA-Like Helices

    International Nuclear Information System (INIS)

    Semchenko, I. V.; Khakhomov, S. A.; Balmakov, A. P.

    2010-01-01

    Currently, 2D and 3D structures of different symmetries can be formed from DNA molecules. The electromagnetic properties of this new natural chiral material can be changed by metalizing DNA. Spatial structures of this type can be used in nanotechnology to prepare metamaterials for the far-UV region. It is shown by the example of an octahedron and a cube composed of DNA-like helices that these structures may exhibit polarization selectivity to electromagnetic radiation. In addition, it is suggested that the effect of the polarization selectivity of DNA-like artificial structures may also occur in the soft X-ray region for all living organisms in nature due to the universal DNA form.

  1. Thermal–structural analysis of ITER triangular support for dominant load verification

    International Nuclear Information System (INIS)

    Kim, Yu-Gyeong; Hwang, Jong-Hyun; Jung, Yung-Jin; Kim, Hyun-Soo; Ahn, Hee-Jae

    2014-01-01

    Highlights: • The load combination method is introduced to thermal–structural analysis for contradictive loads occurred simultaneously. • The one-way coupling analysis also conducted for thermal–structural analysis and its validity is checked by comparing with the load combination. • The dominant load for triangular support bracket is determined as the baking condition. - Abstract: The triangular support is located on the lower inner shell of vacuum vessel of ITER, which should be designed to withstand various loads such as nuclear heat, coolant pressure and so on. The appropriateness of its design is evaluated under the dominant load that could represent the most conservative condition among the design loads. In order to decide the dominant load, a valid method for thermal–structural analysis is firstly verified considering contradictory behaviors between heat and structural loads. In this paper, two approaches; one-way coupling and load combination, are introduced for thermal–structural analysis. The one-way coupling is a method generally used but has a limit to apply on contradictory conditions. The load combination could give a proper solution since it evaluates each load independently and then adds up each result linearly. Based on the results of each case, structural analysis for another load case, baking condition with incident, is conducted to find out which load is dominant for triangular support. Consequently, it is found that the baking condition is the dominant load for triangular support bracket. The proposed load combination method gives a physically reasonable solution which can be used as a reference for checking the validity of other thermal–structural analysis. It is expected that these results could be applied for manufacturing design of the triangular support under various load conditions

  2. Thermal–structural analysis of ITER triangular support for dominant load verification

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yu-Gyeong, E-mail: aspirany@hhi.co.kr [Hyundai Heavy Industries Co., Ltd., 1000, Bangeojinsunhwando-ro, Dong-gu, Ulsan (Korea, Republic of); Hwang, Jong-Hyun; Jung, Yung-Jin [Hyundai Heavy Industries Co., Ltd., 1000, Bangeojinsunhwando-ro, Dong-gu, Ulsan (Korea, Republic of); Kim, Hyun-Soo; Ahn, Hee-Jae [National Fusion Research Institute, 113 Gwahangno, Yuseong-gu, Daejeon-si (Korea, Republic of)

    2014-12-15

    Highlights: • The load combination method is introduced to thermal–structural analysis for contradictive loads occurred simultaneously. • The one-way coupling analysis also conducted for thermal–structural analysis and its validity is checked by comparing with the load combination. • The dominant load for triangular support bracket is determined as the baking condition. - Abstract: The triangular support is located on the lower inner shell of vacuum vessel of ITER, which should be designed to withstand various loads such as nuclear heat, coolant pressure and so on. The appropriateness of its design is evaluated under the dominant load that could represent the most conservative condition among the design loads. In order to decide the dominant load, a valid method for thermal–structural analysis is firstly verified considering contradictory behaviors between heat and structural loads. In this paper, two approaches; one-way coupling and load combination, are introduced for thermal–structural analysis. The one-way coupling is a method generally used but has a limit to apply on contradictory conditions. The load combination could give a proper solution since it evaluates each load independently and then adds up each result linearly. Based on the results of each case, structural analysis for another load case, baking condition with incident, is conducted to find out which load is dominant for triangular support. Consequently, it is found that the baking condition is the dominant load for triangular support bracket. The proposed load combination method gives a physically reasonable solution which can be used as a reference for checking the validity of other thermal–structural analysis. It is expected that these results could be applied for manufacturing design of the triangular support under various load conditions.

  3. Structural Modeling of Variables Related to Parental Support in Mexican Children's Perfomance on Reading and Writing

    Science.gov (United States)

    Bazan-Ramirez, Aldo; Castellanos-Simons, Doris; Lopez-Valenzuela, Mercedes

    2010-01-01

    This paper aims at analysing the structural relationships among some latent and observed variables related to the assessment of written language performance in 139 fourth grade students of Elementary School selected from nine public schools of the northwest of Mexico. Questionnaires were also applied to the children's parents and teachers. The…

  4. Selective Preparation of trans-Carveol over Ceria Supported Mesoporous Materials MCM-41 and SBA-15

    Directory of Open Access Journals (Sweden)

    Nariman F. Salakhutdinov

    2013-05-01

    Full Text Available Ce-modified mesoporous silica materials MCM-41 and SBA-15, namely 32 wt % Ce–Si–MCM-41, 16 wt % Ce–H–MCM-41 and 20 wt % Ce–Si–SBA-15, were prepared, characterized and studied in the selective preparation of trans-carveol by α-pinene oxide isomerization. The characterizations of these catalysts were performed using scanning electron microscopy, X-ray photoelectron spectroscopy, nitrogen adsorption and FTIR pyridine adsorption. Selective preparation of trans-carveol was carried out in the liquid phase in a batch reactor. The activity and the selectivity of catalyst were observed to be influenced by their acidity, basicity and morphology of the mesoporous materials. The formation of trans-carveol is moreover strongly influenced by the basicity of the used solvent and in order to achieve high yields of this desired alcohol it is necessary to use polar basic solvent.

  5. Social justice in education: how the function of selection in educational institutions predicts support for (non)egalitarian assessment practices

    Science.gov (United States)

    Autin, Frédérique; Batruch, Anatolia; Butera, Fabrizio

    2015-01-01

    Educational institutions are considered a keystone for the establishment of a meritocratic society. They supposedly serve two functions: an educational function that promotes learning for all, and a selection function that sorts individuals into different programs, and ultimately social positions, based on individual merit. We study how the function of selection relates to support for assessment practices known to harm vs. benefit lower status students, through the perceived justice principles underlying these practices. We study two assessment practices: normative assessment—focused on ranking and social comparison, known to hinder the success of lower status students—and formative assessment—focused on learning and improvement, known to benefit lower status students. Normative assessment is usually perceived as relying on an equity principle, with rewards being allocated based on merit and should thus appear as positively associated with the function of selection. Formative assessment is usually perceived as relying on corrective justice that aims to ensure equality of outcomes by considering students’ needs, which makes it less suitable for the function of selection. A questionnaire measuring these constructs was administered to university students. Results showed that believing that education is intended to select the best students positively predicts support for normative assessment, through increased perception of its reliance on equity, and negatively predicts support for formative assessment, through reduced perception of its ability to establish corrective justice. This study suggests that the belief in the function of selection as inherent to educational institutions can contribute to the reproduction of social inequalities by preventing change from assessment practices known to disadvantage lower-status student, namely normative assessment, to more favorable practices, namely formative assessment, and by promoting matching beliefs in justice

  6. Social justice in education: how the function of selection in educational institutions predicts support for (non)egalitarian assessment practices.

    Science.gov (United States)

    Autin, Frédérique; Batruch, Anatolia; Butera, Fabrizio

    2015-01-01

    Educational institutions are considered a keystone for the establishment of a meritocratic society. They supposedly serve two functions: an educational function that promotes learning for all, and a selection function that sorts individuals into different programs, and ultimately social positions, based on individual merit. We study how the function of selection relates to support for assessment practices known to harm vs. benefit lower status students, through the perceived justice principles underlying these practices. We study two assessment practices: normative assessment-focused on ranking and social comparison, known to hinder the success of lower status students-and formative assessment-focused on learning and improvement, known to benefit lower status students. Normative assessment is usually perceived as relying on an equity principle, with rewards being allocated based on merit and should thus appear as positively associated with the function of selection. Formative assessment is usually perceived as relying on corrective justice that aims to ensure equality of outcomes by considering students' needs, which makes it less suitable for the function of selection. A questionnaire measuring these constructs was administered to university students. Results showed that believing that education is intended to select the best students positively predicts support for normative assessment, through increased perception of its reliance on equity, and negatively predicts support for formative assessment, through reduced perception of its ability to establish corrective justice. This study suggests that the belief in the function of selection as inherent to educational institutions can contribute to the reproduction of social inequalities by preventing change from assessment practices known to disadvantage lower-status student, namely normative assessment, to more favorable practices, namely formative assessment, and by promoting matching beliefs in justice principles.

  7. Fatigue assessment of central support structure coil jacket of 4.5 MJ SMES

    International Nuclear Information System (INIS)

    Akhter, Javed; Bhunia, Uttam; Mondal, Bidhan Chandra; Nandi, Chinmay; Pal, Gautam; Saha, Subimal

    2013-01-01

    The Superconducting coil of 4.5 SMES will be of sector-toroidal type with 8 sectors. The maximum coil current will be 1200 Amperes. During its life time the SMES will be subjected to several cycles of charging and discharging. Thus the structural assessment of coil central support structure and the Liquid Helium Jacket, which comprises of the stress analysis and the fatigue life assessment, is a critical part of the design. In this paper fatigue life assessment of the 4.5 MJ SMES coil central support structure and the Liquid Helium Jacket together with the related stress analysis is presented. Coupled electromagnetic and Structural analysis using the commercial finite element analysis package ANSYS is performed. Considering the cyclic symmetry of the coil assembly, only 1/8th of the assembly is modelled. (author)

  8. Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors

    Energy Technology Data Exchange (ETDEWEB)

    Katz, Jason D.; Haidle, Andrew; Childers, Kaleen K.; Zabierek, Anna A.; Jewell, James P.; Hou, Yongquan; Altman, Michael D.; Szewczak, Alexander; Chen, Dapeng; Harsch, Andreas; Hayashi, Mansuo; Warren, Lee; Hutton, Michael; Nuthall, Hugh; Su, Hua-Poo; Munshi, Sanjeev; Stanton, Matt G.; Davies, Ian W.; Munoz, Ben; Northrup, Alan (Merck)

    2017-01-01

    The initial structure activity relationships around an isoindoline uHTS hit will be described. Information gleaned from ligand co-crystal structures allowed for rapid refinements in both MARK potency and kinase selectivity. These efforts allowed for the identification of a compound with properties suitable for use as an in vitro tool compound for validation studies on MARK as a viable target for Alzheimer’s disease.

  9. An innovative bio-engineering retaining structure for supporting unstable soil

    Directory of Open Access Journals (Sweden)

    Gianluca Bella

    2017-04-01

    Full Text Available The paper presents a new prefabricated bio-engineering structure for the support of unstable soil. This prefabricated structure is made of a steel frame which is completely filled with soil and a face made of tree trunks among which scions or autochthonous bushes are planted. Due to the difficulties in interpreting the complex interaction between soil and structure during the installation and lifetime, an in situ test was carried out in order to evaluate the state of stress in the steel frame and to understand the global behavior of the structure under service loads. On the basis of the obtained results, a procedure for checking the structure safety was proposed and discussed. An easy design method was developed during the research. Moreover, the use of this type of prefabricated structure shows several advantages, such as good performances in terms of stabilizing effects, and easy assembly and transport.

  10. A Customizable MR Brain Imaging Atlas of Structure and Function for Decision Support.

    Science.gov (United States)

    U., Sinha; S., El-Saden; G., Duckwiler; L., Thompson; S., Ardekani; H., Kangarloo

    2003-01-01

    We present a MR brain atlas for structure and function (diffusion weighted images). The atlas is customizable for contrast and orientation to match the current patient images. In addition, the atlas also provides normative values of MR parameters. The atlas is designed on informatics principles to provide context sensitive decision support at the time of primary image interpretation. Additional support for diagnostic interpretation is provided by a list of expert created most relevant ‘Image Finding Descriptors’ that will serve as cues to the user. The architecture of the atlas module is integrated into the image workflow of a radiology department to provide support at the time of primary diagnosis. PMID:14728244

  11. High-Temperature Superconductors as Electromagnetic Deployment and Support Structures in Spacecraft. [NASA NIAC Phase I

    Science.gov (United States)

    Getliffe, Gwendolyn V.; Inamdar, Niraj K.; Masterson, Rebecca; Miller, David W.

    2012-01-01

    This report, concluding a one-year NIAC Phase I study, describes a new structural and mechanical technique aimed at reducing the mass and increasing the deployed-to-stowed length and volume ratios of spacecraft systems. This technique uses the magnetic fields generated by electrical current passing through coils of high-temperature superconductors (HTSs) to support spacecraft structures and deploy them to operational configurations from their stowed positions inside a launch vehicle fairing.

  12. Optimization of offshore wind turbine support structures using analytical gradient-based method

    OpenAIRE

    Chew, Kok Hon; Tai, Kang; Ng, E.Y.K.; Muskulus, Michael

    2015-01-01

    Design optimization of the offshore wind turbine support structure is an expensive task; due to the highly-constrained, non-convex and non-linear nature of the design problem. This report presents an analytical gradient-based method to solve this problem in an efficient and effective way. The design sensitivities of the objective and constraint functions are evaluated analytically while the optimization of the structure is performed, subject to sizing, eigenfrequency, extreme load an...

  13. Artificial selection for structural color on butterfly wings and comparison with natural evolution.

    Science.gov (United States)

    Wasik, Bethany R; Liew, Seng Fatt; Lilien, David A; Dinwiddie, April J; Noh, Heeso; Cao, Hui; Monteiro, Antónia

    2014-08-19

    Brilliant animal colors often are produced from light interacting with intricate nano-morphologies present in biological materials such as butterfly wing scales. Surveys across widely divergent butterfly species have identified multiple mechanisms of structural color production; however, little is known about how these colors evolved. Here, we examine how closely related species and populations of Bicyclus butterflies have evolved violet structural color from brown-pigmented ancestors with UV structural color. We used artificial selection on a laboratory model butterfly, B. anynana, to evolve violet scales from UV brown scales and compared the mechanism of violet color production with that of two other Bicyclus species, Bicyclus sambulos and Bicyclus medontias, which have evolved violet/blue scales independently via natural selection. The UV reflectance peak of B. anynana brown scales shifted to violet over six generations of artificial selection (i.e., in less than 1 y) as the result of an increase in the thickness of the lower lamina in ground scales. Similar scale structures and the same mechanism for producing violet/blue structural colors were found in the other Bicyclus species. This work shows that populations harbor large amounts of standing genetic variation that can lead to rapid evolution of scales' structural color via slight modifications to the scales' physical dimensions.

  14. Emerging models for mobilizing family support for chronic disease management: a structured review.

    Science.gov (United States)

    Rosland, Ann-Marie; Piette, John D

    2010-03-01

    We identify recent models for programmes aiming to increase effective family support for chronic illness management and self-care among adult patients without significant physical or cognitive disabilities. We then summarize evidence regarding the efficacy for each model identified. Structured review of studies published in medical and psychology databases from 1990 to the present, reference review, general Web searches and conversations with family intervention experts. Review was limited to studies on conditions that require ongoing self-management, such as diabetes, chronic heart disease and rheumatologic disease. Programmes with three separate foci were identified: (1) Programmes that guide family members in setting goals for supporting patient self-care behaviours have led to improved implementation of family support roles, but have mixed success improving patient outcomes. (2) Programmes that train family in supportive communication techniques, such as prompting patient coping techniques or use of autonomy supportive statements, have successfully improved patient symptom management and health behaviours. (3) Programmes that give families tools and infrastructure to assist in monitoring clinical symptoms and medications are being conducted, with no evidence to date on their impact on patient outcomes. The next generation of programmes to improve family support for chronic disease management incorporate a variety of strategies. Future research can define optimal clinical situations for family support programmes, the most effective combinations of support strategies, and how best to integrate family support programmes into comprehensive models of chronic disease care.

  15. Pt nanocatalysts supported on reduced graphene oxide for selective conversion of cellulose or cellobiose to sorbitol.

    Science.gov (United States)

    Wang, Ding; Niu, Wenqi; Tan, Minghui; Wu, Mingbo; Zheng, Xuejun; Li, Yanpeng; Tsubaki, Noritatsu

    2014-05-01

    Pt nanocatalysts loaded on reduced graphene oxide (Pt/RGO) were prepared by means of a convenient microwave-assisted reduction approach with ethylene glycol as reductant. The conversion of cellulose or cellobiose into sorbitol was used as an application reaction to investigate their catalytic performance. Various metal nanocatalysts loaded on RGO were compared and RGO-supported Pt exhibited the highest catalytic activity with 91.5 % of sorbitol yield from cellobiose. The catalytic performances of Pt nanocatalysts supported on different carbon materials or on silica support were also compared. The results showed that RGO was the best catalyst support, and the yield of sorbitol was as high as 91.5 % from cellobiose and 58.9 % from cellulose, respectively. The improvement of catalytic activity was attributed to the appropriate Pt particle size and hydrogen spillover effect of Pt/RGO catalyst. Interestingly, the size and dispersion of supported Pt particles could be easily regulated by convenient adjustment of the microwave heating temperature. The catalytic performance was found to initially increase and then decrease with increasing particle size. The optimum Pt particle size was 3.6 nm. These findings may offer useful guidelines for designing novel catalysts with beneficial catalytic performance for biomass conversion. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. The selective reduction of NO@#x@# with NH@#3@# over zirconia-supported vanadia catalysts

    NARCIS (Netherlands)

    Szakacs, S.; Altena, G.J.; Altena, G.J.; Fransen, T.; van Ommen, J.G.; Ross, J.R.H.; Ross, J.R.H.

    1993-01-01

    A series of sub-monolayer vanadia-on-zirconia catalysts have been prepared and the activities of these have been measured for the selective reduction of NO with NH3. It has been found that the activity per vanadium surface species depends on the square of the vanadium surface coverage. We therefore

  17. The Silent Minority: Supporting Students with Selective Mutism Using Systemic Perspectives

    Science.gov (United States)

    Lawrence, Zena

    2017-01-01

    Selective Mutism (SM) is an under-researched area of child development. While the incidence rate is low, the impact of this difficulty can be pervasive and can present as a significant risk for student mental health and wellbeing. The following article presents a case study focusing on parent-student intervention for a preadolescent male, using an…

  18. The Current State of Empirical Support for the Pharmacological Treatment of Selective Mutism

    Science.gov (United States)

    Carlson, John S.; Mitchell, Angela D.; Segool, Natasha

    2008-01-01

    This article reviews the current state of evidence for the psychopharmacological treatment of children diagnosed with selective mutism within the context of its link to social anxiety disorder. An increased focus on potential medication treatment for this disorder has resulted from significant monetary and resource limitations in typical practice,…

  19. The activity of supported vanadium oxide catalysts for the selective reduction of NO with ammonia

    NARCIS (Netherlands)

    Bosch, H.; Janssen, Frans J.J.G.; van den Kerkhof, Frans M.G.; Oldenziel, Jaap; van Ommen, J.G.; Ross, Julian R.H.

    1986-01-01

    The activities of monolayer V2O5 catalysts for the selective reduction of NO with NH3 are compared with those of commercial available catalysts containing V and/or W. From steady state and pulse experiments it can be concluded that the reduction of surface sites proceeds either by NH3 + NO or by NH3

  20. Using remote sensing in support of environmental management: A framework for selecting products, algorithms and methods

    CSIR Research Space (South Africa)

    De Klerk, HM

    2016-11-01

    Full Text Available Traditionally, to map environmental features using remote sensing, practitioners will use training data to develop models on various satellite data sets using a number of classification approaches and use test data to select a single ‘best performer...

  1. Structure sensitivity in the nonscalable regime explored via catalysed ethylene hydrogenation on supported platinum nanoclusters

    Science.gov (United States)

    Crampton, Andrew S.; Rötzer, Marian D.; Ridge, Claron J.; Schweinberger, Florian F.; Heiz, Ueli; Yoon, Bokwon; Landman, Uzi

    2016-01-01

    The sensitivity, or insensitivity, of catalysed reactions to catalyst structure is a commonly employed fundamental concept. Here we report on the nature of nano-catalysed ethylene hydrogenation, investigated through experiments on size-selected Ptn (n=8-15) clusters soft-landed on magnesia and first-principles simulations, yielding benchmark information about the validity of structure sensitivity/insensitivity at the bottom of the catalyst size range. Both ethylene-hydrogenation-to-ethane and the parallel hydrogenation-dehydrogenation ethylidyne-producing route are considered, uncovering that at the =10) clusters at T>150 K, with maximum room temperature reactivity observed for Pt13. Structure insensitivity, inherent for specific cluster sizes, is induced in the more active Pt13 by a temperature increase up to 400 K leading to ethylidyne formation. Control of sub-nanometre particle size may be used for tuning catalysed hydrogenation activity and selectivity.

  2. Structural determinants for selective recognition of peptide ligands for endothelin receptor subtypes ETA and ETB.

    Science.gov (United States)

    Lättig, Jens; Oksche, Alexander; Beyermann, Michael; Rosenthal, Walter; Krause, Gerd

    2009-07-01

    The molecular basis for recognition of peptide ligands endothelin-1, -2 and -3 in endothelin receptors is poorly understood. Especially the origin of ligand selectivity for ET(A) or ET(B) is not clearly resolved. We derived sequence-structure-function relationships of peptides and receptors from mutational data and homology modeling. Our major findings are the dissection of peptide ligands into four epitopes and the delineation of four complementary structural portions on receptor side explaining ligand recognition in both endothelin receptor subtypes. In addition, structural determinants for ligand selectivity could be described. As a result, we could improve the selectivity of BQ3020 about 10-fold by a single amino acid substitution, validating our hypothesis for ligand selectivity caused by different entrances to the receptors' transmembrane binding sites. A narrow tunnel shape in ET(A) is restrictive for a selected group of peptide ligands' N-termini, whereas a broad funnel-shaped entrance in ET(B) accepts a variety of different shapes and properties of ligands.

  3. Activities in Support of Continuing the Service of Nuclear Power Plant Safety-Related Concrete Structures

    International Nuclear Information System (INIS)

    Naus, Dan J.

    2010-01-01

    Nuclear power plant concrete structures are described. In-service inspection and testing requirements in the U.S. are summarized. The license renewal process in the U.S. is outlined and its current status provided. Operating experience related to performance of the concrete structures is presented. Basic components of a program to manage aging of the concrete structures are identified and described: degradation mechanisms, damage models, and material performance; assessment and remediation (i.e., component selection, in-service inspection, non-destructive examinations, and remedial actions); and estimation of performance at present or some future point in time (i.e., application of structural reliability theory to the design and optimization of in-service inspection/maintenance strategies, and determination of the effects of degradation on plant risk). Finally, areas are noted where additional research would be of benefit to aging management of nuclear power plant concrete structures.

  4. SELECTION OF SCALE OF PICTURE OF STRUCTURE FOR ITS MULTIFRACTAL ANALYSIS

    Directory of Open Access Journals (Sweden)

    VOLCHUK V. N.

    2015-11-01

    Full Text Available Problem statement. Each scale level detectesthe new features of the structure of the material describing of it quality. For example, features of the grain structure are revealed in different kind of steel on microstruc ture level, and its parameters greatly influences on the strength properties of the metal. Thus, to select the scale of representation of a fractal object, for instance the elements of structure of roll iron or steel is necessary to determine the interval (1, where observed its self-similarity, and on this interval should be selected the scale, the use of which will allow him to choose adequate fractal dimension. For optimal scale structure of repose is taken one in which at least two adjacent points of the series (2, the fractal dimension is minimal differences between them. This is explained by the fact that this is best observed property of self-similarity structure. An example of the selection of the scale representation of the structure of cast iron rolls execution of SPHN (a and execution SSHN (b is shown on interval of increases in the range of x 100 to x1000 with a predetermined pitch Δl = 100. The implementation of this phase of research allowed to determine experimentally the optimal scale of representation of structure of iron roll with increasing x 200 for multifractal analysis of its elements: inclusion of the plate and nodular graphit, carbides. Purpose To determine the optimal scale structure representation for iron roll multifractal analysis of its elements: inclusion of the plate and nodular carbides. Conclusion. It was found that the fractal dimension of the structural elements of the test ranged from experimental error 5÷7%, which testifies to the universality of this assessment, and therefore reliability and economic benefits, in terms of the equipping of laboratories expensive metallurgical microscopes with higher resolution.

  5. Selective SiO2 etching in three dimensional structures using parylene-C as mask

    NARCIS (Netherlands)

    Veltkamp, Henk-Willem; Zhao, Yiyuan; de Boer, Meint J.; Wiegerink, Remco J.; Lötters, Joost Conrad

    2017-01-01

    This abstract describes an application of an easy and straightforward method for selective SiO2 etching in three dimensional structures, which is developed by our group. The application in this abstract is the protection of the buried-oxide (BOX) layer of a silicon-on-insulator (SOI) wafer against

  6. SHAPE selection (SHAPES) enrich for RNA structure signal in SHAPE sequencing-based probing data

    DEFF Research Database (Denmark)

    Poulsen, Line Dahl; Kielpinski, Lukasz Jan; Salama, Sofie R

    2015-01-01

    transcriptase. Here, we introduce a SHAPE Selection (SHAPES) reagent, N-propanone isatoic anhydride (NPIA), which retains the ability of SHAPE reagents to accurately probe RNA structure, but also allows covalent coupling between the SHAPES reagent and a biotin molecule. We demonstrate that SHAPES...

  7. Genome Scan for Selection in Structured Layer Chicken Populations Exploiting Linkage Disequilibrium Information.

    Directory of Open Access Journals (Sweden)

    Mahmood Gholami

    Full Text Available An increasing interest is being placed in the detection of genes, or genomic regions, that have been targeted by selection because identifying signatures of selection can lead to a better understanding of genotype-phenotype relationships. A common strategy for the detection of selection signatures is to compare samples from distinct populations and to search for genomic regions with outstanding genetic differentiation. The aim of this study was to detect selective signatures in layer chicken populations using a recently proposed approach, hapFLK, which exploits linkage disequilibrium information while accounting appropriately for the hierarchical structure of populations. We performed the analysis on 70 individuals from three commercial layer breeds (White Leghorn, White Rock and Rhode Island Red, genotyped for approximately 1 million SNPs. We found a total of 41 and 107 regions with outstanding differentiation or similarity using hapFLK and its single SNP counterpart FLK respectively. Annotation of selection signature regions revealed various genes and QTL corresponding to productions traits, for which layer breeds were selected. A number of the detected genes were associated with growth and carcass traits, including IGF-1R, AGRP and STAT5B. We also annotated an interesting gene associated with the dark brown feather color mutational phenotype in chickens (SOX10. We compared FST, FLK and hapFLK and demonstrated that exploiting linkage disequilibrium information and accounting for hierarchical population structure decreased the false detection rate.

  8. An Innovative Structural Mode Selection Methodology: Application for the X-33 Launch Vehicle Finite Element Model

    Science.gov (United States)

    Hidalgo, Homero, Jr.

    2000-01-01

    An innovative methodology for determining structural target mode selection and mode selection based on a specific criterion is presented. An effective approach to single out modes which interact with specific locations on a structure has been developed for the X-33 Launch Vehicle Finite Element Model (FEM). We presented Root-Sum-Square (RSS) displacement method computes resultant modal displacement for each mode at selected degrees of freedom (DOF) and sorts to locate modes with highest values. This method was used to determine modes, which most influenced specific locations/points on the X-33 flight vehicle such as avionics control components, aero-surface control actuators, propellant valve and engine points for use in flight control stability analysis and for flight POGO stability analysis. Additionally, the modal RSS method allows for primary or global target vehicle modes to also be identified in an accurate and efficient manner.

  9. Quantitative structure-activity relationships of selective antagonists of glucagon receptor using QuaSAR descriptors.

    Science.gov (United States)

    Manoj Kumar, Palanivelu; Karthikeyan, Chandrabose; Hari Narayana Moorthy, Narayana Subbiah; Trivedi, Piyush

    2006-11-01

    In the present paper, quantitative structure activity relationship (QSAR) approach was applied to understand the affinity and selectivity of a novel series of triaryl imidazole derivatives towards glucagon receptor. Statistically significant and highly predictive QSARs were derived for glucagon receptor inhibition by triaryl imidazoles using QuaSAR descriptors of molecular operating environment (MOE) employing computer-assisted multiple regression procedure. The generated QSAR models revealed that factors related to hydrophobicity, molecular shape and geometry predominantly influences glucagon receptor binding affinity of the triaryl imidazoles indicating the relevance of shape specific steric interactions between the molecule and the receptor. Further, QSAR models formulated for selective inhibition of glucagon receptor over p38 mitogen activated protein (MAP) kinase of the compounds in the series highlights that the same structural features, which influence the glucagon receptor affinity, also contribute to their selective inhibition.

  10. Cancer Feature Selection and Classification Using a Binary Quantum-Behaved Particle Swarm Optimization and Support Vector Machine

    Directory of Open Access Journals (Sweden)

    Maolong Xi

    2016-01-01

    Full Text Available This paper focuses on the feature gene selection for cancer classification, which employs an optimization algorithm to select a subset of the genes. We propose a binary quantum-behaved particle swarm optimization (BQPSO for cancer feature gene selection, coupling support vector machine (SVM for cancer classification. First, the proposed BQPSO algorithm is described, which is a discretized version of original QPSO for binary 0-1 optimization problems. Then, we present the principle and procedure for cancer feature gene selection and cancer classification based on BQPSO and SVM with leave-one-out cross validation (LOOCV. Finally, the BQPSO coupling SVM (BQPSO/SVM, binary PSO coupling SVM (BPSO/SVM, and genetic algorithm coupling SVM (GA/SVM are tested for feature gene selection and cancer classification on five microarray data sets, namely, Leukemia, Prostate, Colon, Lung, and Lymphoma. The experimental results show that BQPSO/SVM has significant advantages in accuracy, robustness, and the number of feature genes selected compared with the other two algorithms.

  11. Cancer Feature Selection and Classification Using a Binary Quantum-Behaved Particle Swarm Optimization and Support Vector Machine

    Science.gov (United States)

    Sun, Jun; Liu, Li; Fan, Fangyun; Wu, Xiaojun

    2016-01-01

    This paper focuses on the feature gene selection for cancer classification, which employs an optimization algorithm to select a subset of the genes. We propose a binary quantum-behaved particle swarm optimization (BQPSO) for cancer feature gene selection, coupling support vector machine (SVM) for cancer classification. First, the proposed BQPSO algorithm is described, which is a discretized version of original QPSO for binary 0-1 optimization problems. Then, we present the principle and procedure for cancer feature gene selection and cancer classification based on BQPSO and SVM with leave-one-out cross validation (LOOCV). Finally, the BQPSO coupling SVM (BQPSO/SVM), binary PSO coupling SVM (BPSO/SVM), and genetic algorithm coupling SVM (GA/SVM) are tested for feature gene selection and cancer classification on five microarray data sets, namely, Leukemia, Prostate, Colon, Lung, and Lymphoma. The experimental results show that BQPSO/SVM has significant advantages in accuracy, robustness, and the number of feature genes selected compared with the other two algorithms. PMID:27642363

  12. Webvise: Browser and Proxy support for open hypermedia structuring mechanisms on the WWW

    DEFF Research Database (Denmark)

    Grønbæk, Kaj; Sloth, Lennard; Ørbæk, Peter

    1999-01-01

    Web pages. Support for providing links to/from parts of non-HTML data, such as sound and movie, will be possible via interfaces to plug-ins and Java-based media players. The hypermedia structures are stored in a hypermedia database, developed from the Devise Hypermedia framework, and the service...... be manipulated and used via special Java applets and a pure proxy server solution is provided for users who only need to browse the structures. A user can create and use the external structures as ‘transparency' layers on top of arbitrary Web pages, the user can switch between viewing pages with one or more...

  13. 3D printing PLA and silicone elastomer structures with sugar solution support material

    Science.gov (United States)

    Hamidi, Armita; Jain, Shrenik; Tadesse, Yonas

    2017-04-01

    3D printing technology has been used for rapid prototyping since 1980's and is still developing in a way that can be used for customized products with complex design and miniature features. Among all the available 3D printing techniques, Fused Deposition Modeling (FDM) is one of the most widely used technologies because of its capability to build different structures by employing various materials. However, complexity of parts made by FDM is greatly limited by restriction of using support materials. Support materials are often used in FDM for several complex geometries such as fully suspended shapes, overhanging surfaces and hollow features. This paper describes an approach to 3D print a structure using silicone elastomer and polylactide fiber (PLA) by employing a novel support material that is soluble in water. This support material is melted sugar which can easily be prepared at a low cost. Sugar is a carbohydrate, which is found naturally in plants such as sugarcane and sugar beets; therefore, it is completely organic and eco-friendly. As another advantage, the time for removing this material from the part is considerably less than other commercially available support materials and it can be removed easily by warm water without leaving any trace. Experiments were done using an inexpensive desktop 3D printer to fabricate complex structures for use in soft robots. The results envision that further development of this system would contribute to a method of fabrication of complex parts with lower cost yet high quality.

  14. 77 FR 14787 - Federal Home Loan Bank Members Selected for Community Support Review

    Science.gov (United States)

    2012-03-13

    ... 2010 fifth round community support review cycle: Federal Home Loan Bank of Boston--District 1 People's... Association Canton Georgia. Bank of Chickamauga Chickamauga Georgia. The Peoples Bank Eatonton Georgia. The........... Kentucky. Peoples Bank of Kentucky, Inc Flemingsburg......... Kentucky. The Farmers Bank Hardinsburg...

  15. Artificial neural network decision support systems for new product development project selection

    NARCIS (Netherlands)

    Thieme, R.J.; Song, Michael; Calantone, R.J.

    2000-01-01

    The authors extend and develop an artificial neural network decision support system and demonstrate how it can guide managers when they make complex new product development decisions. The authors use data from 612 projects to compare this new method with traditional methods for predicting various

  16. Fuzzy Decision Support for Tools Selection in the Core Front End Activities of New Product Development

    DEFF Research Database (Denmark)

    Achiche, S.; Appio, F.P.; McAloone, Tim C.

    2013-01-01

    models (FDSM) of the discovered relationships. The decision support focuses upon the estimated investment needed for the use of tools during the CFE. The generation of FDSMs is carried out automatically using a specialized genetic algorithm, applied to learning data obtained from five experienced...

  17. Bayesian inference supports the host selection hypothesis in explaining adaptive host specificity by European bitterling

    Czech Academy of Sciences Publication Activity Database

    Smith, Carl

    2017-01-01

    Roč. 183, č. 2 (2017), s. 379-389 ISSN 0029-8549 R&D Projects: GA ČR GA13-05872S Institutional support: RVO:68081766 Keywords : Brood parasite * Host–parasite co-evolution * Oviposition * Spawning site * Superparasitism Subject RIV: EG - Zoology OBOR OECD: Ecology Impact factor: 3.130, year: 2016

  18. Accounting Procedures and Controls Over Financial Data Supporting Selected Other Defense Organizations

    National Research Council Canada - National Science Library

    2000-01-01

    ... and funds that use the Treasury Index 97 symbol. In support of our audit of the DoD Agency-Wide financial statements for FY 1999, we audited accounting procedures and controls for the three largest organizations that received full accounting...

  19. 34 CFR 410.21 - What selection criteria does the Secretary use for institutional support grants?

    Science.gov (United States)

    2010-07-01

    ... number of students enrolled, attendance rates, dropout rates, graduation rates, rate of job placement or college enrollment after graduation, and the most significant scholastic problems affecting the student... instructional and student support needs, and equipment and capital requirements. (c) Implementation strategy...

  20. Optimal support vessel and access system selection for offshore wind farms

    NARCIS (Netherlands)

    Asgarpour, M.; Serraris, J.W.; Ridder, E. de; Broek, J. van den; Bos, J.E.

    2016-01-01

    Operation and maintenance (O&M) costs contribute to a significant part of Cost of Energy produced by offshore wind. In order to reduce the O&M costs and to guarantee safety and wellbeing of the maintenance technicians, for each individual wind farm an optimal set of support vessels and access