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Sample records for supplement ma huang

  1. [Herbological studies on Chinese crude drug Ma-huang. Part 1-On the botanical origin of Ma-huang in ancient China and the origin of Japanese Ma-huang].

    Science.gov (United States)

    Yoshizawa, Chieko; Kitade, Makiko; Mikage, Masayuki

    2005-01-01

    The botanical origin of a Chinese crude drug Ma-huang in ancient China and the origin of Japanese Ma-huang were herbologically studied. The results showed that the plants of Ephedra sinica Stapf, E. intermedia Schrenk & C. A. Meyer and E. equisetina Bunge were used as Ma-huang in China, and the first species was considered to be of high quality. The characters of Mao-zhou Ma-huang and Tong-zhou Ma-huang printed in Tu-jing-ben-cao, published in the Song Dynasty in China, were identified as E. likiangensis Florin and E. intermedia, respectively, and both species were recognized as excellent Ma-huang in the Ming Dynasty. The word origin of Katsune-kusa, the Japanese name for Ma-huang in the Heian Era, was etymologically considered as meaning the plant having reddish brown roots. In Japan, the plant of Equisetum ramosissimum Desf. var.japonicum Milde, of the family Equisetaceae, was substituted for Ma-huang in the middle of Edo Era, and it was designated that this action was based on the confusion of Ephedra plants and Equisetum plants those days in China.

  2. Effects of Gui Zhi Ma Huang Ge Ban Tang on the TLR7 Pathway in Influenza Virus Infected Mouse Lungs in a Cold Environment.

    Science.gov (United States)

    Qin, Hong-Qiong; Shi, Shan-Shan; Fu, Ying-Jie; Yan, Yu-Qi; Wu, Sha; Tang, Xiao-Long; Chen, Xiao-Yin; Hou, Guang-Hui; Jiang, Zhen-You

    2018-01-01

    We wished to investigate the effects of the traditional Chinese medicine Gui Zhi Ma Huang Ge Ban Tang on controlling influenza A virus (IAV) infection and improving inflammation in mouse lungs. Mice were maintained in normal and cold environments and infected with IAV by intranasal application, respectively. Real-time quantitative polymerase chain reaction was used to measure mRNA expression of TLR7, myeloid differentiation primary response 88 (MyD88), and nuclear factor-kappa B (NF- κ B)p65 in the TLR7 signaling pathway and virus replication in lungs. Western blotting was used to measure expression levels of TLR7, MyD88, and NF- κ B p65 proteins. Flow cytometry was used to detect the proportion of T-helper (Th)1/Th2 and Th17/T-regulatory (Treg) cells. Application of Gui Zhi Ma Huang Ge Ban Tang in influenza-infected mice in a cold environment showed (i) downregulation of TLR7, MyD88, and NF- κ Bp65; (ii) inhibition of transcriptional activities of promoters coding for TLR7, MyD88, and NF- κ Bp65; (iii) reduction in the proportion of Th1/Th2 and Th17/Treg cells. Gui Zhi Ma Huang Ge Ban Tang had a good therapeutic effect on mice infected with IAV, especially in the cold environment. It could reduce lung inflammation in mice significantly and elicit an anti-influenza effect by downregulating expression of the key factors in TLR7 signaling pathway.

  3. Ma

    Directory of Open Access Journals (Sweden)

    Ingrid Berthon-Moine

    2012-01-01

    Full Text Available Ma (2009 is a single channel video of a mother and child walking together side by side, holding hands. The title is reminiscent of the affectionate nickname for a mother, 'Ma', but also a concealed way to convey maternal ambivalence. Maternal ambivalence is the result of the tension between the idealisation of motherhood and women’s lived experience of mothering. The maternal struggle finds its source in the difficulty of identifying with the ideological representation of the mother. This image still conveys an idealistic and nostalgic, patriarchal image of maternal love bounded by culture and history. http://podcast.ulcc.ac.uk/accounts/BirkbeckCollege/mamsie/MA.mov

  4. Huang diffuse scattering of neutrons

    International Nuclear Information System (INIS)

    Burkel, E.; Guerard, B. v.; Metzger, H.; Peisl, J.

    1979-01-01

    Huang diffuse neutron scattering was measured for the first time on niobium with interstitially dissolved deuterium as well as on MgO after neutron irradiation and Li 7 F after γ-irradiation. With Huang diffuse scattering the strength and symmetry of the distortion field around lattice defects can be determined. Our results clearly demonstrate that this method is feasible with neutrons. The present results are compared with X-ray experiments and the advantages of using neutrons is discussed in some detail. (orig.)

  5. Revised Huang-Yang multipolar pseudopotential

    International Nuclear Information System (INIS)

    Derevianko, Andrei

    2005-01-01

    A number of authors have recently pointed out inconsistencies of results obtained with the Huang-Yang multipolar pseudopotential for low-energy scattering [K. Huang and K. C. Yang, Phys. Rev. 105, 767 (1957); later revised by Huang, Statistical Mechanics (Wiley, New York, 1963)]. The conceptual validity of their original derivation has been questioned. Here I show that these inconsistencies are rather due to an algebraic mistake made by Huang and Yang. With the corrected error, I present the revised version of the multipolar pseudopotential

  6. An Increase in Dietary Supplement Exposures Reported to US Poison Control Centers.

    Science.gov (United States)

    Rao, Nisha; Spiller, Henry A; Hodges, Nichole L; Chounthirath, Thiphalak; Casavant, Marcel J; Kamboj, Amrit K; Smith, Gary A

    2017-09-01

    The objective of this study was to investigate the epidemiology of dietary supplement exposures in the USA. A retrospective analysis was conducted of out-of-hospital dietary supplement exposures reported to the National Poison Data System from 2000 through 2012. There were 274,998 dietary supplement exposures from 2000 through 2012. The annual rate of dietary supplement exposures per 100,000 population increased by 46.1% during 2000-2002, decreased 8.8% during 2002-2005, and then increased again by 49.3% from 2005 to 2012. These trends were influenced by the decrease in ma huang exposures starting in 2002. Miscellaneous dietary supplements accounted for 43.9% of all exposures, followed by botanicals (31.9%), hormonal products (15.1%), and other supplements (5.1%). The majority of dietary supplement exposures (70.0%) occurred among children younger than 6 years old and were acute (94.0%) and unintentional (82.9%). Serious medical outcomes accounted for 4.5% of exposures and most (95.0%) occurred among individuals 6 years and older. Ma huang products, yohimbe, and energy products were the categories associated with the greatest toxicity. There was an overall increase in the rate of dietary supplement exposures from 2000 through 2012. Although the majority of these exposures did not require treatment at a health care facility or result in serious medical outcomes, exposures to yohimbe and energy products were associated with considerable toxicity. Our results demonstrate the success of the FDA ban on ma huang products and the need for FDA regulation of yohimbe and energy products in the USA.

  7. Structural phase transitions and Huang scattering

    International Nuclear Information System (INIS)

    Yamada, Yasusada

    1980-01-01

    The usefulness of the application of the concept of Huang scattering to the understandings of the origin of diffuse scatterings near structural phase transitions are discussed. It is pointed out that in several phase transitions, the observed diffuse scatterings can not be interpreted in terms of critical fluctuations of the order parameters associated with the structural phase transitions, and that they are rather interpreted as Huang scattering due to random distribution of individual order parameter which is 'dressed' by strain fields. Examples to show effective applications of this concept to analyze the experimental X-ray data and whence to understand microscopic mechanisms of structural phase transitions are presented. (author)

  8. Non-integrability of the Huang--Li nonlinear financial model

    OpenAIRE

    Szumiński, Wojciech

    2017-01-01

    In this paper we consider Huang--Li nonlinear financial system recently studied in the literature. It has the form of three first order differential equations \\[ \\dot x=z+(y-a)x,\\quad \\dot y=1-b y-x^2,\\quad \\dot z=-x-c z, \\] where $(a,b,c)$ are real positive parameters. We show that this system is not integrable in the class of functions meromorphic in variables $(x,y,z)$. We give an analytic proof of this fact analysing properties the of differential Galois group of variational equations alo...

  9. Gear Fault Detection Based on Teager-Huang Transform

    Directory of Open Access Journals (Sweden)

    Hui Li

    2010-01-01

    Full Text Available Gear fault detection based on Empirical Mode Decomposition (EMD and Teager Kaiser Energy Operator (TKEO technique is presented. This novel method is named as Teager-Huang transform (THT. EMD can adaptively decompose the vibration signal into a series of zero mean Intrinsic Mode Functions (IMFs. TKEO can track the instantaneous amplitude and instantaneous frequency of the Intrinsic Mode Functions at any instant. The experimental results provide effective evidence that Teager-Huang transform has better resolution than that of Hilbert-Huang transform. The Teager-Huang transform can effectively diagnose the fault of the gear, thus providing a viable processing tool for gearbox defect detection and diagnosis.

  10. Weight Loss Nutritional Supplements

    Science.gov (United States)

    Eckerson, Joan M.

    Obesity has reached what may be considered epidemic proportions in the United States, not only for adults but for children. Because of the medical implications and health care costs associated with obesity, as well as the negative social and psychological impacts, many individuals turn to nonprescription nutritional weight loss supplements hoping for a quick fix, and the weight loss industry has responded by offering a variety of products that generates billions of dollars each year in sales. Most nutritional weight loss supplements are purported to work by increasing energy expenditure, modulating carbohydrate or fat metabolism, increasing satiety, inducing diuresis, or blocking fat absorption. To review the literally hundreds of nutritional weight loss supplements available on the market today is well beyond the scope of this chapter. Therefore, several of the most commonly used supplements were selected for critical review, and practical recommendations are provided based on the findings of well controlled, randomized clinical trials that examined their efficacy. In most cases, the nutritional supplements reviewed either elicited no meaningful effect or resulted in changes in body weight and composition that are similar to what occurs through a restricted diet and exercise program. Although there is some evidence to suggest that herbal forms of ephedrine, such as ma huang, combined with caffeine or caffeine and aspirin (i.e., ECA stack) is effective for inducing moderate weight loss in overweight adults, because of the recent ban on ephedra manufacturers must now use ephedra-free ingredients, such as bitter orange, which do not appear to be as effective. The dietary fiber, glucomannan, also appears to hold some promise as a possible treatment for weight loss, but other related forms of dietary fiber, including guar gum and psyllium, are ineffective.

  11. Spatiotemporal variations in precipitation on the Huang-Huai-Hai ...

    Indian Academy of Sciences (India)

    47

    The Huang-Huai-Hai Plain is an important grain production base for food security ... Then, data from nearby sites was used to fill date gaps in these sites. ...... could decreased the grain number and yield of maize on the Huang-Huai-Hai Plain,.

  12. Huang Zongxi's and John Locke's Rhetoric toward Modernity

    Science.gov (United States)

    Wang, Xiaobo

    2012-01-01

    Huang Zongxi was an influential seventeenth century Chinese political and social theorist who is considered by many to be the inspiration and founding father of democracy and human rights in China. This article examines the many similarities in thought and social influence between Huang and his contemporary, the English philosopher John Locke.…

  13. Zhigang Ma

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. Zhigang Ma. Articles written in Bulletin of Materials Science. Volume 35 Issue 4 August 2012 pp 575-578. Degradation and miscibility of poly(DL-lactic acid)/poly(glycolic acid) composite films: Effect of poly(DL-lactic-co-glycolic acid) · Zhigang Ma Na Zhao Chengdong Xiong.

  14. [Doctor HUANG Shi-ping's acupuncture with golden needles].

    Science.gov (United States)

    Chen, Teng-Fei; Ma, Zeng-Bin; Xin, Si-Yuan; Zhu, Jiang

    2013-08-01

    Taking Doctor HUANG Shi-ping as the representative, the school of Huang's golden needle is based on Chinese martial art. Golden needles are adopted as main tool. Attaching great importance on the combination of acupuncture and moxibustioin, it is also characterized with penetrating needling with long needles. Through the development of three generations, it once outshone other schools in the field of acupuncture, and became famous all over the world. It made great contribution to the development of the course of acupuncture. However, with the development of the history, the form of acupuncture education as well as apparatus were all undergone an unified reform. Therefore, Doctor HUANG Shi-ping's acupuncture school be lost gradually.

  15. Adole, MA

    African Journals Online (AJOL)

    Adole, MA. Vol 4, No 1 (2011) - Articles Effects of Groundnut Husk Ash-blended Cement on Chemical Resistance of Concrete Abstract PDF. ISSN: 1596-6035. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

  16. Tan's distributions and Fermi-Huang pseudopotential in momentum space

    DEFF Research Database (Denmark)

    Valiente, Manuel

    2012-01-01

    form of the Fourier-transformed pseudopotential remains very simple. Operator forms for the so-called Tan's selectors, which, together with Fermi-Huang pseudopotential, largely simplify the derivation of Tan's universal relations for the Fermi gas, are here derived and are also very simple. A momentum...

  17. Arrhythmogenicity of weight-loss supplements marketed on the Internet.

    Science.gov (United States)

    Nazeri, Alireza; Massumi, Ali; Wilson, James M; Frank, Christopher M; Bensler, Michael; Cheng, Jie; Saeed, Mohammad; Rasekh, Abdi; Razavi, Mehdi

    2009-05-01

    We examined nonprescription weight-loss supplements marketed on the Internet for ingredients with potential arrhythmogenic and life-threatening cardiac adverse effects. We aimed to define the risks of life-threatening cardiac adverse effects that are associated with weight-loss supplements marketed on the Internet. We entered the key words "weight-loss supplements" and "diet pills" into three popular Internet search engines. The top four nonoverlapping hits from each search engine were purchased. After receipt, the products and their ingredient lists were inspected, and Medline and the Natural Medicines Comprehensive Database were searched for reports of significant associations between each ingredient and various key words for life-threatening cardiac adverse effects. All supplements had the list of ingredients on the label. We identified 60 different ingredients (7.25 +/- 4.66 per supplement; range 1-21). Eleven ingredients representing eight different substances (because multiple names were used for some substances) were each associated with two or more reports of life-threatening cardiac complications or death. Eight of the 12 products contained one or more such ingredients, but none of these eight products had warnings about life-threatening cardiac adverse effects on the Web pages, on the labels, or in the package inserts. One product contained ma huang (Chinese ephedra), even though the marketing of ephedra-containing products is banned in the United States. The Internet provides easy access to weight-loss supplements, several of which contain ingredients with potentially life-threatening adverse effects. There is a need for increased public education and awareness regarding such weight-loss products.

  18. International Roughness Index (IRI) measurement using Hilbert-Huang transform

    Science.gov (United States)

    Zhang, Wenjin; Wang, Ming L.

    2018-03-01

    International Roughness Index (IRI) is an important metric to measure condition of roadways. This index is usually used to justify the maintenance priority and scheduling for roadways. Various inspection methods and algorithms are used to assess this index through the use of road profiles. This study proposes to calculate IRI values using Hilbert-Huang Transform (HHT) algorithm. In particular, road profile data is provided using surface radar attached to a vehicle driving at highway speed. Hilbert-Huang transform (HHT) is used in this study because of its superior properties for nonstationary and nonlinear data. Empirical mode decomposition (EMD) processes the raw data into a set of intrinsic mode functions (IMFs), representing various dominating frequencies. These various frequencies represent noises from the body of the vehicle, sensor location, and the excitation induced by nature frequency of the vehicle, etc. IRI calculation can be achieved by eliminating noises that are not associated with the road profile including vehicle inertia effect. The resulting IRI values are compared favorably to the field IRI values, where the filtered IMFs captures the most characteristics of road profile while eliminating noises from the vehicle and the vehicle inertia effect. Therefore, HHT is an effect method for road profile analysis and for IRI measurement. Furthermore, the application of HHT method has the potential to eliminate the use of accelerometers attached to the vehicle as part of the displacement measurement used to offset the inertia effect.

  19. Recent studies of point defects by Huang scattering of x rays

    International Nuclear Information System (INIS)

    Maeta, Hiroshi

    1977-01-01

    Huang scattering allows the measurements of the symmetry and strength of point defects produced by irradiations and constitutes a very sensitive method for observing the clustering that occurs during irradiations or annealings. In the present review, the principles and characteristics of the Huang scattering and recent investigations using this technique are described. [J.Cryst.Soc.Japan 19,231(1977)] (auth.)

  20. Comment on the analysis of Bethe-Salpeter scattering states by Hormozdiari and Huang

    International Nuclear Information System (INIS)

    Tryon, E.P.

    1978-01-01

    The analysis of Bethe-Salpeter scattering states by Hormozdiari and Huang appears to contain invalid mathematical arguments. When these arguments are rectified, one arrives at substantially different conclusions. In particular, the prescription of Hormozdiari and Huang for constructing such states does not seem applicable to any process occurring in nature

  1. Preanesthetic Assessment of Herbal and Dietary Supplement Use

    Science.gov (United States)

    2000-10-01

    in the U.S. in 1995 were echinacea, garlic, goldenseal, ginseng, ginkgo, saw palmetto, ma huang, aloe, Siberian ginseng, and cranberry . Since then, St...should be avoided by patients taking prednisone and in patients with manic- depressive disorders and psychosis (Miller, 1998). Fishman, Catarau, Sachs

  2. Resolving Nonstationary Spectral Information in Wind Speed Time Series Using the Hilbert-Huang Transform

    DEFF Research Database (Denmark)

    Vincent, Claire Louise; Giebel, Gregor; Pinson, Pierre

    2010-01-01

    a 4-yr time series of 10-min wind speed observations. An adaptive spectral analysis method called the Hilbert–Huang transform is chosen for the analysis, because the nonstationarity of time series of wind speed observations means that they are not well described by a global spectral analysis method...... such as the Fourier transform. The Hilbert–Huang transform is a local method based on a nonparametric and empirical decomposition of the data followed by calculation of instantaneous amplitudes and frequencies using the Hilbert transform. The Hilbert–Huang transformed 4-yr time series is averaged and summarized...

  3. [Academic heritage of Jiu huang ben cao (Materia Medica for Relief of Famines) in Japan].

    Science.gov (United States)

    He, Huiling; Xiao, Yongzhi

    2014-11-01

    Jiu huang ben cao (Materia Medica for Relief of Famines) was the first monograph on famines herbal in the history of China, which creates a new research field of edible plants. Around the middle and late 17th century, Jiu huang ben cao was spread to Japan and aroused great attention of famous Japanese herbalists. Thus, all versions of different edition systems were circulated in Japan. Later, some famous Japanese scholar ssuccessively quoted texts of Jiu huang ben cao from the Nong zheng quan shu (Whole book on Agricultural Administration) spread in Japan, and block-printed it as an independent work. As a result, Jiu huang ben cao virtually circulated widely in Japan.

  4. Chinese Middle Classes: Taiwan, Hong Kong, Macao and China. Edited by Hsin-Huang Michael Hsiao

    DEFF Research Database (Denmark)

    Brødsgaard, Kjeld Erik

    2018-01-01

    Book review of: Chinese Middle Classes:Taiwan, Hong Kong, Macao and China. Edited by Hsin-Huang Michael Hsiao. Abingdon: Routledge, 2014. Pp. 268. ISBN 10: 1138120847; ISBN 13: 978-1138120846......Book review of: Chinese Middle Classes:Taiwan, Hong Kong, Macao and China. Edited by Hsin-Huang Michael Hsiao. Abingdon: Routledge, 2014. Pp. 268. ISBN 10: 1138120847; ISBN 13: 978-1138120846...

  5. Application of Hilbert-Huang Transform in Generating Spectrum-Compatible Earthquake Time Histories

    OpenAIRE

    Ni, Shun-Hao; Xie, Wei-Chau; Pandey, Mahesh

    2011-01-01

    Spectrum-compatible earthquake time histories have been widely used for seismic analysis and design. In this paper, a data processing method, Hilbert-Huang transform, is applied to generate earthquake time histories compatible with the target seismic design spectra based on multiple actual earthquake records. Each actual earthquake record is decomposed into several components of time-dependent amplitude and frequency by Hilbert-Huang transform. The spectrum-compatible earthquake time history ...

  6. Seizure classification in EEG signals utilizing Hilbert-Huang transform

    Directory of Open Access Journals (Sweden)

    Abdulhay Enas W

    2011-05-01

    Full Text Available Abstract Background Classification method capable of recognizing abnormal activities of the brain functionality are either brain imaging or brain signal analysis. The abnormal activity of interest in this study is characterized by a disturbance caused by changes in neuronal electrochemical activity that results in abnormal synchronous discharges. The method aims at helping physicians discriminate between healthy and seizure electroencephalographic (EEG signals. Method Discrimination in this work is achieved by analyzing EEG signals obtained from freely accessible databases. MATLAB has been used to implement and test the proposed classification algorithm. The analysis in question presents a classification of normal and ictal activities using a feature relied on Hilbert-Huang Transform. Through this method, information related to the intrinsic functions contained in the EEG signal has been extracted to track the local amplitude and the frequency of the signal. Based on this local information, weighted frequencies are calculated and a comparison between ictal and seizure-free determinant intrinsic functions is then performed. Methods of comparison used are the t-test and the Euclidean clustering. Results The t-test results in a P-value Conclusion An original tool for EEG signal processing giving physicians the possibility to diagnose brain functionality abnormalities is presented in this paper. The proposed system bears the potential of providing several credible benefits such as fast diagnosis, high accuracy, good sensitivity and specificity, time saving and user friendly. Furthermore, the classification of mode mixing can be achieved using the extracted instantaneous information of every IMF, but it would be most likely a hard task if only the average value is used. Extra benefits of this proposed system include low cost, and ease of interface. All of that indicate the usefulness of the tool and its use as an efficient diagnostic tool.

  7. Seizure classification in EEG signals utilizing Hilbert-Huang transform.

    Science.gov (United States)

    Oweis, Rami J; Abdulhay, Enas W

    2011-05-24

    Classification method capable of recognizing abnormal activities of the brain functionality are either brain imaging or brain signal analysis. The abnormal activity of interest in this study is characterized by a disturbance caused by changes in neuronal electrochemical activity that results in abnormal synchronous discharges. The method aims at helping physicians discriminate between healthy and seizure electroencephalographic (EEG) signals. Discrimination in this work is achieved by analyzing EEG signals obtained from freely accessible databases. MATLAB has been used to implement and test the proposed classification algorithm. The analysis in question presents a classification of normal and ictal activities using a feature relied on Hilbert-Huang Transform. Through this method, information related to the intrinsic functions contained in the EEG signal has been extracted to track the local amplitude and the frequency of the signal. Based on this local information, weighted frequencies are calculated and a comparison between ictal and seizure-free determinant intrinsic functions is then performed. Methods of comparison used are the t-test and the Euclidean clustering. The t-test results in a P-value with respect to its fast response and ease to use. An original tool for EEG signal processing giving physicians the possibility to diagnose brain functionality abnormalities is presented in this paper. The proposed system bears the potential of providing several credible benefits such as fast diagnosis, high accuracy, good sensitivity and specificity, time saving and user friendly. Furthermore, the classification of mode mixing can be achieved using the extracted instantaneous information of every IMF, but it would be most likely a hard task if only the average value is used. Extra benefits of this proposed system include low cost, and ease of interface. All of that indicate the usefulness of the tool and its use as an efficient diagnostic tool.

  8. Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics.

    Science.gov (United States)

    García-Cortés, Miren; Robles-Díaz, Mercedes; Ortega-Alonso, Aida; Medina-Caliz, Inmaculada; Andrade, Raul J

    2016-04-09

    Dietary supplements (DS) are extensively consumed worldwide despite unproven efficacy. The true incidence of DS-induced liver injury (DSILI) is unknown but is probably under-diagnosed due to the general belief of safety of these products. Reported cases of herbals and DS-induced liver injury are increasing worldwide. The aim of this manuscript is to report a tabular listing with a description of DS associated with hepatotoxicity as well as review the phenotype and severity of DSILI. Natural remedies related to hepatotoxicity can be divided into herbal product-induced liver injury and DS-induced liver injury. In this article, we describe different DS associated with liver injury, some of them manufactured DS containing several ingredients (Herbalife™ products, Hydroxycut™, LipoKinetix™, UCP-1 and OxyELITE™) while others have a single ingredient (green tea extract, linoleic acid, usnic acid, 1,3-Dimethylamylamine, vitamin A, Garcinia cambogia and ma huang). Additional DS containing some of the aforementioned ingredients implicated in liver injury are also covered. We have also included illicit androgenic anabolic steroids for bodybuilding in this work, as they are frequently sold under the denomination of DS despite being conventional drugs.

  9. Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics

    Directory of Open Access Journals (Sweden)

    Miren García-Cortés

    2016-04-01

    Full Text Available Dietary supplements (DS are extensively consumed worldwide despite unproven efficacy. The true incidence of DS-induced liver injury (DSILI is unknown but is probably under-diagnosed due to the general belief of safety of these products. Reported cases of herbals and DS-induced liver injury are increasing worldwide. The aim of this manuscript is to report a tabular listing with a description of DS associated with hepatotoxicity as well as review the phenotype and severity of DSILI. Natural remedies related to hepatotoxicity can be divided into herbal product-induced liver injury and DS-induced liver injury. In this article, we describe different DS associated with liver injury, some of them manufactured DS containing several ingredients (Herbalife™ products, Hydroxycut™, LipoKinetix™, UCP-1 and OxyELITE™ while others have a single ingredient (green tea extract, linoleic acid, usnic acid, 1,3-Dimethylamylamine, vitamin A, Garcinia cambogia and ma huang. Additional DS containing some of the aforementioned ingredients implicated in liver injury are also covered. We have also included illicit androgenic anabolic steroids for bodybuilding in this work, as they are frequently sold under the denomination of DS despite being conventional drugs.

  10. Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics

    Science.gov (United States)

    García-Cortés, Miren; Robles-Díaz, Mercedes; Ortega-Alonso, Aida; Medina-Caliz, Inmaculada; Andrade, Raul J.

    2016-01-01

    Dietary supplements (DS) are extensively consumed worldwide despite unproven efficacy. The true incidence of DS-induced liver injury (DSILI) is unknown but is probably under-diagnosed due to the general belief of safety of these products. Reported cases of herbals and DS-induced liver injury are increasing worldwide. The aim of this manuscript is to report a tabular listing with a description of DS associated with hepatotoxicity as well as review the phenotype and severity of DSILI. Natural remedies related to hepatotoxicity can be divided into herbal product-induced liver injury and DS-induced liver injury. In this article, we describe different DS associated with liver injury, some of them manufactured DS containing several ingredients (Herbalife™ products, Hydroxycut™, LipoKinetix™, UCP-1 and OxyELITE™) while others have a single ingredient (green tea extract, linoleic acid, usnic acid, 1,3-Dimethylamylamine, vitamin A, Garcinia cambogia and ma huang). Additional DS containing some of the aforementioned ingredients implicated in liver injury are also covered. We have also included illicit androgenic anabolic steroids for bodybuilding in this work, as they are frequently sold under the denomination of DS despite being conventional drugs. PMID:27070596

  11. Genetic structure of Mount Huang honey bee (Apis cerana) populations: evidence from microsatellite polymorphism.

    Science.gov (United States)

    Liu, Fang; Shi, Tengfei; Huang, Sisi; Yu, Linsheng; Bi, Shoudong

    2016-01-01

    The Mount Huang eastern honey bees ( Apis cerana ) are an endemic population, which is well adapted to the local agricultural and ecological environment. In this study, the genetic structure of seven eastern honey bees ( A. cerana ) populations from Mount Huang in China were analyzed by SSR (simple sequence repeat) markers. The results revealed that 16 pairs of primers used amplified a total of 143 alleles. The number of alleles per locus ranged from 6 to 13, with a mean value of 8.94 alleles per locus. Observed and expected heterozygosities showed mean values of 0.446 and 0.831 respectively. UPGMA cluster analysis grouped seven eastern honey bees in three groups. The results obtained show a high genetic diversity in the honey bee populations studied in Mount Huang, and high differentiation among all the populations, suggesting that scarce exchange of honey bee species happened in Mount Huang. Our study demonstrated that the Mount Huang honey bee populations still have a natural genome worth being protected for conservation.

  12. Cutting force response in milling of Inconel: analysis by wavelet and Hilbert-Huang Transforms

    Directory of Open Access Journals (Sweden)

    Grzegorz Litak

    Full Text Available We study the milling process of Inconel. By continuously increasing the cutting depth we follow the system response and appearance of oscillations of larger amplitude. The cutting force amplitude and frequency analysis has been done by means of wavelets and Hilbert-Huang transform. We report that in our system the force oscillations are closely related to the rotational motion of the tool and advocate for a regenerative mechanism of chatter vibrations. To identify vibrations amplitudes occurrence in time scale we apply wavelet and Hilbert-Huang transforms.

  13. Methods for detection and characterization of signals in noisy data with the Hilbert-Huang transform

    International Nuclear Information System (INIS)

    Stroeer, Alexander; Cannizzo, John K.; Camp, Jordan B.; Gagarin, Nicolas

    2009-01-01

    The Hilbert-Huang transform is a novel, adaptive approach to time series analysis that does not make assumptions about the data form. Its adaptive, local character allows the decomposition of nonstationary signals with high time-frequency resolution but also renders it susceptible to degradation from noise. We show that complementing the Hilbert-Huang transform with techniques such as zero-phase filtering, kernel density estimation and Fourier analysis allows it to be used effectively to detect and characterize signals with low signal-to-noise ratios.

  14. Reply to Ridoutt and Huang: From water footprint assessment to policy

    NARCIS (Netherlands)

    Hoekstra, Arjen Y.; Mekonnen, Mesfin

    2012-01-01

    According to Ridoutt and Huang (1), “environmental relevance must be taken into consideration if water footprints are to inform wise decision making and policy development.” Indeed, reduction targets regarding water footprints (WFs) within catchments should be formulated on the basis of relative

  15. Analysis of the Cofrentes instability with the Hilbert-Huang transform

    International Nuclear Information System (INIS)

    Blazquez, J.; Galindo, A.

    2010-01-01

    The most obvious application of the Hilbert-Huang transform is the denoising (signal isolation). In this article, the dynamic system is the power of a BWR reactor that undergoes instability. The signal and the dynamic systems are described, which in this case corresponds to a current incident in a commercial BWR reactor (Cofrentes). Finally, empirical modes are calculated and the results are analyzed.

  16. Concentration dependence of the Huang scattering intensity of TaHsub(x) alloys

    International Nuclear Information System (INIS)

    Behr, H.; Metzger, H.; Peisl, J.

    1983-01-01

    The analysis of the concentration dependence of the Huang diffuse scattering intensity from ThHsub(x) single crystals has been re-evaluated using two quantities recently determined from independent measurements of the Bragg diffraction intensities. Good agreement between experiment and theory has been achieved. (author)

  17. Yin Zhi Huang and other plant-derived preparations: where herbal and molecular medicine meet

    NARCIS (Netherlands)

    Elferink, Ronald Oude

    2004-01-01

    Yin Zhi Huang, a decoction of Yin Chin (Artemisia capillaris) and three other herbs, is widely used in Asia to prevent and treat neonatal jaundice. We recently identified the constitutive androstane receptor (CAR, NR113) as a key regulator of bilirubin clearance in the liver. Here we show that

  18. Efecto de la suplementación con residuos de destilería del maíz en el comportamiento de novillas en una asociación de gramínea y leucaena Effect of supplementation with corn distillery residues on the performance of heifers in an association of grass and leucaena

    Directory of Open Access Journals (Sweden)

    Tania Sánchez

    2010-09-01

    Full Text Available El objetivo del presente trabajo fue evaluar el efecto de la suplementación con residuos de destilería del maíz en el comportamiento de novillas, en una asociación de gramínea y leucaena. El estudio se realizó en un área de la Estación Experimental "Indio Hatuey", en el municipio de Perico, provincia de Matanzas, Cuba. La especie de pasto predominante fue Panicum maximum cv. Likoni y como leguminosa Leucaena leucocephala. Se estudiaron 18 novillas, distribuidas en un diseño completamente aleatorizado en tres grupos de seis animales; el grupo control no recibió suplementación (A y los otros dos grupos se suplementaron con residuos de destilería del maíz en un 10% (B y 20% (C de los requerimientos de proteína con relación al peso vivo. Se determinó la composición química, la disponibilidad de materia seca, la ganancia de peso vivo, la infestaci��n parasitaria y el hematocrito. Al analizar las ganancias diarias por tratamiento se encontraron diferencias significativas (PThe objective of this work was to evaluate the effect of supplementation with corn distillery residues on the performance of heifers in an association of grass and leucaena. The study was conducted in an area of the Experimental Station "Indio Hatuey" , Perico municipality, Matanzas province, Cuba. The prevailing pasture species was Panicum maximum cv. Likoni and as legume, Leucaena leucocephala. Eighteen heifers, distributed in a completely randomized design in three groups of six animals, were used; the control group did not receive supplementation (A, and the other two groups were supplemented with corn distillery residues in 10% (B and 20% (C of the protein requirements with regards to live weight. The chemical composition, dry matter availability, live weight gain, parasite infestation and hematocrit were determined. When analyzing the daily gain per treatments, significant differences (P<0,05 were found and the highest values were obtained in treatment C

  19. Calculation of the Huang-Rhys parameter in spherical quantum dots: the optical deformation potential effect

    International Nuclear Information System (INIS)

    Hamma, M; Miranda, R P; Vasilevskiy, M I; Zorkani, I

    2007-01-01

    An accurate calculation of the exciton-phonon interaction matrix elements and Huang-Rhys parameter for nearly spherical nanocrystals (NCs) of polar semiconductor materials is presented. The theoretical approach is based on a continuum lattice dynamics model and the effective mass approximation for electronic states in the NCs. A strong confinement regime is considered for both excitons and optical phonons, taking into account both the Froehlich-type and optical deformation potential (ODP) mechanisms of the exciton-phonon interaction. The effects of exchange electron-hole interaction and possible hexagonal crystal structure of the underlying material are also taken into account. The theory is applied to CdSe and InP quantum dots. It is shown that the ODP mechanism, almost unimportant for CdSe, dominates the exciton-phonon coupling in small InP dots. The effect of the non-diagonal interaction, not included in the Huang-Rhys parameter, is briefly discussed

  20. Huang scattering from self-interstitials in electron-irradiated Fe-40 at % Al ordered alloy

    International Nuclear Information System (INIS)

    Guillot, J.P.; Riviere, J.P.; Beaufort-Richard, M.F.

    1983-01-01

    A single crystal of Fe-40 at % Al ordered alloy has been irradiated with 2.5 MeV electrons at liquid hydrogen temperature, and diffuse X-ray scattering (MoKα 1 ) near Bragg reflections has been studied after annealing the sample up to 300 K. The characteristic diffuse scattering from point defects with weak displacement fields (Huang diffusion) has been observed near the (200) Bragg reflection in the directions [011] and [100] and near the (110) reflection in the directions [110] and [110]. This Huang scattering has been attributed to self interstitials since under the same irradiations conditions, electrical resistivity measurements indicate that the long range migration of self interstitials by annihilation at vacancies would occur only for temperatures higher than 300 K. The comparison of the experimental results with the different simple intertitial configurations proposed for b.c.c. crystals suggest that the most probable configuration should be the [110] split interstitial with orthorhombic symmetry [fr

  1. Employing the Hilbert-Huang Transform to analyze observed natural complex signals: Calm wind meandering cases

    Science.gov (United States)

    Martins, Luis Gustavo Nogueira; Stefanello, Michel Baptistella; Degrazia, Gervásio Annes; Acevedo, Otávio Costa; Puhales, Franciano Scremin; Demarco, Giuliano; Mortarini, Luca; Anfossi, Domenico; Roberti, Débora Regina; Costa, Felipe Denardin; Maldaner, Silvana

    2016-11-01

    In this study we analyze natural complex signals employing the Hilbert-Huang spectral analysis. Specifically, low wind meandering meteorological data are decomposed into turbulent and non turbulent components. These non turbulent movements, responsible for the absence of a preferential direction of the horizontal wind, provoke negative lobes in the meandering autocorrelation functions. The meandering characteristic time scales (meandering periods) are determined from the spectral peak provided by the Hilbert-Huang marginal spectrum. The magnitudes of the temperature and horizontal wind meandering period obtained agree with the results found from the best fit of the heuristic meandering autocorrelation functions. Therefore, the new method represents a new procedure to evaluate meandering periods that does not employ mathematical expressions to represent observed meandering autocorrelation functions.

  2. Frequency hopping signal detection based on wavelet decomposition and Hilbert-Huang transform

    Science.gov (United States)

    Zheng, Yang; Chen, Xihao; Zhu, Rui

    2017-07-01

    Frequency hopping (FH) signal is widely adopted by military communications as a kind of low probability interception signal. Therefore, it is very important to research the FH signal detection algorithm. The existing detection algorithm of FH signals based on the time-frequency analysis cannot satisfy the time and frequency resolution requirement at the same time due to the influence of window function. In order to solve this problem, an algorithm based on wavelet decomposition and Hilbert-Huang transform (HHT) was proposed. The proposed algorithm removes the noise of the received signals by wavelet decomposition and detects the FH signals by Hilbert-Huang transform. Simulation results show the proposed algorithm takes into account both the time resolution and the frequency resolution. Correspondingly, the accuracy of FH signals detection can be improved.

  3. Principles of diet therapy in ancient Chinese medicine: 'Huang Di Nei Jing'.

    Science.gov (United States)

    Ho, Z C

    1993-06-01

    Huang Di Nei Jing, the first systematic Chinese medical book, was compiled from the observations of imperial herbal doctors in the Qin and Han periods (221 BC - 220 AD). From this classic traditional source may be derived the concept of a balanced and complete diet and probably the world's first dietary guidelines. Basic to the tradition are han, re, wen and bu foods, respectively 'cold', 'hot', 'neutral', 'strengthening'. Basic to Chinese cuisine are jan and tsai- 'cereal' (the rice staple and main meal) and 'dishes' to accompany the rice. Chinese traditional medicine, as in Huang Di Nei Jing, considers the nourishment of body and mind. It also emphasises that herbal medicine and food have the same origin. Diet was essential to the prevention of disease which a glossary of Chinese terms is given at the end of the paper in the Chinese tradition, was superior to treatment.

  4. Ma(d)skulinitet

    DEFF Research Database (Denmark)

    Leer, Jonatan

    Når tv-kokke som Jamie Oliver, Gordon Ramsay og brødrene Price toner frem på skærmen, laver de ikke kun mad. De mixer også maskulinitet. For når en mand laver mad, laver maden også manden. Det mener postdoc Jonatan Leer, der i Ma(ds)kulinitet. Kønskamp i tv-køkkenet præsenterer, hvordan og hvorfor...

  5. Froehlih coupling with LO-phonons in quantum dots. Huang-Rhys phenomena

    International Nuclear Information System (INIS)

    Banyai, L.

    1991-01-01

    The quantum coupling between photoexcited carriers and longitudinal optical (LO) phonons in zero-dimensional structures (quantum dots) is considered. A classical model of the electron-phonon interaction is presented. The polarization field is then quantized and the Huang-Rhys phenomenon is observed. Effects induced by the quantization of the electron system are also considered. Finally, the modifications of the theory due to specific aspects of quantum dots are discussed. (Author)

  6. 42 CFR 422.102 - Supplemental benefits.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Supplemental benefits. 422.102 Section 422.102... (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Benefits and Beneficiary Protections § 422.102 Supplemental benefits. (a) Mandatory supplemental benefits. (1) Subject to CMS approval, an MA organization may...

  7. Metal and Stone, Brush and Ink: Word as Source in the Art of Huang Binhong

    Directory of Open Access Journals (Sweden)

    Claire M. Roberts

    2012-09-01

    Full Text Available Like many of his contemporaries, scholar-artist Huang Binhong (1865-1955 received a classical education with deep foundations in text-based historical learning that engendered creative expression in the form of painting, calligraphy and seal carving. While based on cultural traditions of the past, these scholarly arts were directed at experiencing the present and imagining the future. Calligraphy and painting may be understood as the living embodiment of the artist who is vitally connected to the historical past, whereas the printed impression of words or images carved into stone conveys ideas associated with authenticity, longevity and artistic completion. When combined in a brush-and-ink painting there is an interesting tension between the spiritual and temporal; the historical and contemporary. During his lifetime, Huang Binhong was highly regarded as a scholar, art historian, art editor, collector and connoisseur, as well as an artist. His multiple identities formed an integral part of his creative practice. This paper will discuss aspects of Huang Binhong’s life as a scholar, connoisseur-collector and artist, referring to his writings on seals, first published in the Journal of the National Essence (Guocui xuebao and his involvement with the Shanghai-based art magazine National Glories of Cathay (Shenzhou guoguang ji. It will also analyse some of Huang’s paintings in which, through colophons, he makes a direct connection between the study of ancient inscriptions in bronze and stone and contemporary creativity. Through this example it is possible to reflect on ways that contemporary Chinese artists have drawn on the mutual interdependence of word and image to create compelling works of experimental art.

  8. Sports Supplements

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Sports Supplements KidsHealth / For Teens / Sports Supplements What's in ... really work? And are they safe? What Are Sports Supplements? Sports supplements (also called ergogenic aids ) are ...

  9. [Characteristics of precipitation pH and conductivity at Mt. Huang].

    Science.gov (United States)

    Shi, Chun-e; Deng, Xue-liang; Wu, Bi-wen; Hong, Jie; Zhang, Su; Yang, Yuan-jian

    2013-05-01

    To understand the general characteristics of pH distribution and pollution in precipitation at Mt. Huang, statistical analyses were conducted for the routine measurements of pH and conductivity (K) at Mt. Huang during 2006-2011. The results showed that: (1) Over the period of study, the annual volume weighted mean (VWM) precipitation pH varied from 4.81 to 5.57, with precipitation acidity strengthening before 2009 and weakening thereafter. The precipitation acidity showed evident seasonal variations, with the VWM pH lowest in winter (4.78), and highest in summer (5.33). The occurrence frequency of acid rain was 46% , accounting for 45% of total rainfalls and with the most frequent pH falling into weak acid to neutral rain. (2) The annual VWM K varied from 16.91 to 27.84 microS x cm(-1), with no evident trend. As for ions pollution, the precipitation was relatively clean at Mt. Huang, with the most frequent K range being below 15 microS x cm(-1), followed by 15-25 microS x cm(-1). From February 2010 to December 2011, precipitation samples were collected on daily basis for ions analysis, as well as pH and K measurement in lab. Detailed comparisons were conducted between the two sets of pH and K, one set from field measurement and the other from lab measurement. The results indicated: (1) The lab measured pH (K) was highly correlated with the field pH (K); however, the lab pH tended to move towards neutral comparing with the corresponding field pH, and the shift range was closely correlated with the field pH and rainfall. The shift range of K from field to lab was highly correlated with the total ion concentration of precipitation. The field K showed evident negative correlation with the field pH with a correlation coefficient of -0.51. (2) When sampling with nylon-polyethylene bags, the statistics showed smaller bias between two sets of pH, with higher correlation coefficient between two sets of K. Furthermore, the lab K also showed evident negative correlation with

  10. Millennium Ecosystem Assessment: MA Ecosystems

    Data.gov (United States)

    National Aeronautics and Space Administration — The Millennium Ecosystem Assessment: MA Ecosystems provides data and information on the extent and classification of ecosystems circa 2000, including coastal,...

  11. Millennium Ecosystem Assessment: MA Biodiversity

    Data.gov (United States)

    National Aeronautics and Space Administration — The Millennium Ecosystem Assessment: MA Biodiversity provides data and information on amphibians, disease agents (extent and distribution of infectious and parasitic...

  12. Discovery and utilization of sorghum genes (Ma5/Ma6)

    Science.gov (United States)

    Mullet, John E; Rooney, William L; Klein, Patricia E; Morishige, Daryl; Murphy, Rebecca; Brady, Jeff A

    2012-11-13

    Methods and composition for the production of non-flowering or late flowering sorghum hybrid. For example, in certain aspects methods for use of molecular markers that constitute the Ma5/Ma6 pathway to modulate photoperiod sensitivity are described. The invention allows the production of plants having improved productivity and biomass generation.

  13. Searching the beginning of BWR power instability events with the Hilbert Huang transform

    International Nuclear Information System (INIS)

    Blázquez, Juan; Montalvo, Cristina; García-Berrocal, Agustín; Balbás, Miguel

    2013-01-01

    Highlights: ► The report of the instability is enriched by including its beginning and its end. ► The Hilbert Huang transform (HHT) is used for indentifying both. ► The first Intrinsic Mode Function (IMF) detects both. ► The methodology is applied to neutron detector signals from two plants. ► The Decay Ratio of IMF 1 is calculated. - Abstract: When a BWR instability takes place, the Regulator usually demands a report which must include many aspects such as the initial time of the instability and also the measurements adopted by the operator at that time. This initial time normally is difficult to know from the available data. In this work, a methodology is proposed to determine accurately when the instability began based on the Hilbert–Huang transform. The Empirical Mode Decomposition is applied to neutron detector signals coming from two plants which have recorded them during real instability events. The first intrinsic mode function shows sharply the beginning and the end of the incident. Besides, through the instantaneous amplitude and frequency of the first mode a kind of Decay Ratio can be assigned allowing us to obtain a sharper description of the instability

  14. Using the Hilbert–Huang transform to measure the electroencephalographic effect of propofol

    International Nuclear Information System (INIS)

    Shalbaf, R; Behnam, H; Sleigh, J W; Voss, L J

    2012-01-01

    Monitoring the effect of anesthetic drugs on the central nervous system is a major ongoing challenge in anesthesia research. A number of electroencephalogram (EEG)-based monitors of the anesthetic drug effect such as the bispectral (BIS) index have been proposed to analyze the EEG signal during anesthesia. However, the BIS index has received some criticism. This paper offers a method based on the Hilbert–Huang transformation to calculate an index, called the Hilbert–Huang weighted regional frequency (HHWRF), to quantify the effect of propofol on brain activity. The HHWRF and BIS indices are applied to EEG signals collected from nine patients during a controlled propofol induction and emergence scheme. The results show that both the HHWRF and BIS track the gross changes in the EEG with increasing and decreasing anesthetic drug effect (the prediction probability P k of 0.85 and 0.83 for HHWRF and BIS, respectively). Our new index can reflect the transition from unconsciousness to consciousness faster than the BIS, as indicated from the pharmacokinetic and pharmacodynamic modeled parameters and also from the analysis around the point of reawakening. This method could be used to design a new EEG monitoring system to estimate the propofol anesthetic drug effect. (paper)

  15. Prediction of unknown deep foundation lengths using the Hilbert Huang Transform (HHT

    Directory of Open Access Journals (Sweden)

    Ahmed T.M. Farid

    2012-08-01

    Full Text Available Prediction of unknown deep foundation embedment depth is a great deal nowadays, especially in case of upgrading or rehabilitation of old structures. Many old bridges and marine or pier structures in the United States are established using deep foundations system of timber piles and their foundation records do not exist. Non-Destructive Testing (NDT or Non-Destructive Evaluation (NDE method for a great variety of materials and structures has become an integral part of many tests. However, the process of testing long piles, deeply embedded in the ground, is more complex than (NDT of the other structural materials. This paper summarizes some of the most common non-destructive test methods for deep foundations and presents a new method called the Hilbert Huang Transform (HHT. This Hilbert Huang Transform (HHT method is used now by a wide range in a different health monitoring of many systems. In this paper, some field tests on the timber Piles of one bridge at North Carolina was performed to verify the using the (HHT method for predicting the embedded depth of the unknown piles. Percentage of the accuracy achieved using HHT method for pile length compared to the actual pile length data was performed. Finally, a recommendation is presented for the limitation of using this new method as a new non-destructive method for deep foundations.

  16. Extraction of microseismic waveforms characteristics prior to rock burst using Hilbert-Huang transform

    Science.gov (United States)

    Li, Xuelong; Li, Zhonghui; Wang, Enyuan; Feng, Junjun; Chen, Liang; Li, Nan; Kong, Xiangguo

    2016-09-01

    This study provides a new research idea concerning rock burst prediction. The characteristics of microseismic (MS) waveforms prior to and during the rock burst were studied through the Hilbert-Huang transform (HHT). In order to demonstrate the advantage of the MS features extraction based on HHT, the conventional analysis method (Fourier transform) was also used to make a comparison. The results show that HHT is simple and reliable, and could extract in-depth information about the characteristics of MS waveforms. About 10 days prior to the rock burst, the main frequency of MS waveforms transforms from the high-frequency to low-frequency. What's more, the waveforms energy also presents accumulation characteristic. Based on our study results, it can be concluded that the MS signals analysis through HHT could provide valuable information about the coal or rock deformation and fracture.

  17. An enhanced Hilbert–Huang transform technique for bearing condition monitoring

    International Nuclear Information System (INIS)

    Osman, Shazali; Wang, Wilson

    2013-01-01

    A new technique, enhanced Hilbert–Huang transform (eHHT), is proposed in this work for fault detection in rolling element bearings. It includes two processes: firstly, the collected vibration signal is denoised to highlight defect-related impulses; and secondly the denoised signal is further processed by the use of the proposed eHHT technique to identify the defect features for bearing fault detection. Signal denoising is carried out by the use of the minimum entropy deconvolution filter to reduce impedance effect of the transmission path of the measured signal. In the proposed eHHT, a novel strategy is proposed to enhance feature extraction based on the analysis of correlation and mutual information. The effectiveness of the proposed eHHT technique in feature extraction and analysis is verified by a series of experimental tests corresponding to different bearing conditions. Its robustness is examined by using data sets from a different resource. (paper)

  18. Incipient Stator Insulation Fault Detection of Permanent Magnet Synchronous Wind Generators Based on Hilbert–Huang Transformation

    DEFF Research Database (Denmark)

    Wang, Chao; Liu, Xiao; Chen, Zhe

    2014-01-01

    of insulation degradation of one turn in the winding of a PMSWG. Cosimulation method by combining finite element model and external circuits is used. Hilbert–Huang transformation is applied to detect the very early stage fault in interturn insulation by analyzing the stator current. Detection results show...

  19. A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome

    OpenAIRE

    Huang, Jehn-Yu; Yeh, Po-Ting; Hou, Yu-Chih

    2016-01-01

    Jehn-Yu Huang, Po-Ting Yeh, Yu-Chih Hou Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan Purpose: To evaluate the efficacy of oral antioxidant supplementation in the treatment of patients with dry eye syndrome (DES). Methods: A prospective, randomized, double-blinded study compared the effects of an antioxidant supplement (containing anthocyanosides, astaxanthin, vitamins A, C, and E, and several herbal extract...

  20. Millennium Ecosystem Assessment: MA Population

    Data.gov (United States)

    National Aeronautics and Space Administration — The Millennium Ecosystem Assessment: MA Population data sets provide baseline population information as one of the drivers of ecosystem change. The data helped in...

  1. Scaling of X pinches from 1 MA to 6 MA

    International Nuclear Information System (INIS)

    Bland, Simon Nicholas; McBride, Ryan D.; Wenger, David Franklin; Sinars, Daniel Brian; Chittenden, Jeremy Paul; Pikuz, Sergei A.; Harding, Eric; Jennings, Christopher A.; Ampleford, David J.; Yu, Edmund P.; Cuneo, Michael Edward; Shelkovenko, Tatiana A.; Hansen, Stephanie B.

    2010-01-01

    This final report for Project 117863 summarizes progress made toward understanding how X-pinch load designs scale to high currents. The X-pinch load geometry was conceived in 1982 as a method to study the formation and properties of bright x-ray spots in z-pinch plasmas. X-pinch plasmas driven by 0.2 MA currents were found to have source sizes of 1 micron, temperatures >1 keV, lifetimes of 10-100 ps, and densities >0.1 times solid density. These conditions are believed to result from the direct magnetic compression of matter. Physical models that capture the behavior of 0.2 MA X pinches predict more extreme parameters at currents >1 MA. This project developed load designs for up to 6 MA on the SATURN facility and attempted to measure the resulting plasma parameters. Source sizes of 5-8 microns were observed in some cases along with evidence for high temperatures (several keV) and short time durations (<500 ps).

  2. Comments on the Huang and Taylor model of ion-implanted silicon-gate depletion-mode IGFET

    International Nuclear Information System (INIS)

    Marciniak, W.; Madura, H.

    1985-01-01

    Recently the Huang and Taylor model (HT model) of built-in channel MOS transistors has been widely used in the analysis of electronic circuits because of its relative simplicity. Huang and Taylor assumed that the effects of the finite channel thickness may be represented by an average semiconductor capacitance in series with the gate oxide capacitance. The derivation of the current-voltage characteristics is based on a linear equation of surface depleted charge density Qsub(s), which is calculated as the sheet charge of constant capacitance C-bar. This is done instead of using the exact solution of the Poisson equation, which has a rather complex form of nonlinear relationship between the charge Qsub(s) and the gate voltage. The basic equation is given. (author)

  3. Time-frequency analysis of non-stationary fusion plasma signals using an improved Hilbert-Huang transform

    International Nuclear Information System (INIS)

    Liu, Yangqing; Tan, Yi; Xie, Huiqiao; Wang, Wenhao; Gao, Zhe

    2014-01-01

    An improved Hilbert-Huang transform method is developed to the time-frequency analysis of non-stationary signals in tokamak plasmas. Maximal overlap discrete wavelet packet transform rather than wavelet packet transform is proposed as a preprocessor to decompose a signal into various narrow-band components. Then, a correlation coefficient based selection method is utilized to eliminate the irrelevant intrinsic mode functions obtained from empirical mode decomposition of those narrow-band components. Subsequently, a time varying vector autoregressive moving average model instead of Hilbert spectral analysis is performed to compute the Hilbert spectrum, i.e., a three-dimensional time-frequency distribution of the signal. The feasibility and effectiveness of the improved Hilbert-Huang transform method is demonstrated by analyzing a non-stationary simulated signal and actual experimental signals in fusion plasmas

  4. Inhibitory Effects of Daiokanzoto (Da-Huang-Gan-Cao-Tang on P-Glycoprotein

    Directory of Open Access Journals (Sweden)

    Yuka Watanabe

    2012-01-01

    Full Text Available We have studied the effects of various Kampo medicines on P-glycoprotein (P-gp, a drug transporter, in vitro. The present study focused on Daiokanzoto (Da-Huang-Gan-Cao-Tang, which shows the most potent inhibitory effects on P-gp among the 50 Kampo medicines studied, and investigated the P-gp inhibitory effects of Daiokanzoto herbal ingredients (rhubarb and licorice root and their components by an ATPase assay using human P-gp membrane. Both rhubarb and licorice root significantly inhibited ATPase activity, and the effects of rhubarb were more potent than those of licorice root. The content of rhubarb in Daiokanzoto is double that in licorice root, and the inhibition patterns of Daiokanzoto and rhubarb involve both competitive and noncompetitive inhibition, suggesting that the inhibitory effects of Daiokanzoto are mainly due to rhubarb. Concerning the components of rhubarb, concentration-dependent inhibitory effects were observed for (−-catechin gallate, (−-epicatechin gallate, and (−-epigallocatechin gallate. In conclusion, rhubarb may cause changes in the drug dispositions of P-gp substrates through the inhibition of P-gp. It appears that attention should be given to the interactions between these drugs and Kampo medicines containing rhubarb as an herbal ingredient.

  5. Treatment of electrochemical noise data by the Hilbert-Huang transform

    International Nuclear Information System (INIS)

    Rahier, A.

    2009-01-01

    Most of the classical approaches for treating electro-chemical noise (ECN) data suffer from the non-linear and non steady-state character of the delivered signal. Very often, the link between time and the local corrosion events supposedly responsible for ECN data signatures is lost during treatment, as is obvious when using the classical Fourier Transform (FT), followed by an analysis of the response in the frequency domain. In this particular case, the information directly related to the corrosion events is distributed into the full spectra, thereby preventing the operator to derive clear and precise conclusions. In 2005, we suggested an alternative data treatment based on the Hilbert-Huang transform (HHT). The latter keeps track of the time variable and copes with non-linear and non steady-state behaviours of the system under examination. In 2006, we demonstrated the applicability of the newly proposed data treatment in the case of ECN data collected under BWR (Boiling Water Reactor) conditions. In 2007, we collected additional ECN data and started a preliminary investigation of two mathematical restrictions that are susceptible to impair the interpretation of the results. We discovered a possible modification of the Hilbert transform allowing generating controlled phase shifts that are different from pi/2 as is always the case for the Hilbert transform

  6. Bearing fault detection utilizing group delay and the Hilbert-Huang transform

    International Nuclear Information System (INIS)

    Jin, Shuai; Lee, Sang-Kwon

    2017-01-01

    Vibration signals measured from a mechanical system are useful to detect system faults. Signal processing has been used to extract fault information in bearing systems. However, a wide vibration signal frequency band often affects the ability to obtain the effective fault features. In addition, a few oscillation components are not useful at the entire frequency band in a vibration signal. By contrast, useful fatigue information can be embedded in the noise oscillation components. Thus, a method to estimate which frequency band contains fault information utilizing group delay was proposed in this paper. Group delay as a measure of phase distortion can indicate the phase structure relationship in the frequency domain between original (with noise) and denoising signals. We used the empirical mode decomposition of a Hilbert-Huang transform to sift the useful intrinsic mode functions based on the results of group delay after determining the valuable frequency band. Finally, envelope analysis and the energy distribution after the Hilbert transform were used to complete the fault diagnosis. The practical bearing fault data, which were divided into inner and outer race faults, were used to verify the efficiency and quality of the proposed method

  7. Bioaccessibility and excretion of arsenic in Niu Huang Jie Du Pian pills

    International Nuclear Information System (INIS)

    Koch, Iris; Sylvester, Steven; Lai, Vivian W.-M.; Owen, Andrew; Reimer, Kenneth J.; Cullen, William R.

    2007-01-01

    Traditional Chinese medicines (TCMs) often contain significant levels of potentially toxic elements, including arsenic. Niu Huang Jie Du Pian pills were analyzed to determine the concentration, bioaccessibility (arsenic fraction soluble in the human gastrointestinal system) and chemical form (speciation) of arsenic. Arsenic excretion in urine (including speciation) and facial hair were studied after a one-time ingestion. The pills contained arsenic in the form of realgar, and although the total arsenic that was present in a single pill was high (28 mg), the low bioaccessibility of this form of arsenic predicted that only 4% of it was available for absorption into the bloodstream (1 mg of arsenic per pill). The species of arsenic that were solubilized were inorganic arsenate (As(V)) and arsenite (As(III)) but DMAA and MMAA were detected in urine. Two urinary arsenic excretion peaks were observed: an initial peak several (4-8) hours after ingestion corresponding to the excretion of predominantly As(III), and a larger peak at 14 h corresponding predominantly to DMAA and MMAA. No methylated As(III) species were observed. Facial hair analysis revealed that arsenic concentrations did not increase significantly as a result of the ingestion. Arsenic is incompletely soluble under human gastrointestinal conditions, and is metabolized from the inorganic to organic forms found in urine. Bioaccessible arsenic is comparable to the quantity excreted. Facial hair as a bio-indicator should be further tested

  8. Hilbert-Huang transform analysis of long-term solar magnetic activity

    Science.gov (United States)

    Deng, Linhua

    2018-04-01

    Astronomical time series analysis is one of the hottest and most important problems, and becomes the suitable way to deal with the underlying dynamical behavior of the considered nonlinear systems. The quasi-periodic analysis of solar magnetic activity has been carried out by various authors during the past fifty years. In this work, the novel Hilbert-Huang transform approach is applied to investigate the yearly numbers of polar faculae in the time interval from 1705 to 1999. The detected periodicities can be allocated to three components: the first one is the short-term variations with periods smaller than 11 years, the second one is the mid- term variations with classical periods from 11 years to 50 years, and the last one is the long-term variations with periods larger than 50 years. The analysis results improve our knowledge on the quasi-periodic variations of solar magnetic activity and could be provided valuable constraints for solar dynamo theory. Furthermore, our analysis results could be useful for understanding the long-term variations of solar magnetic activity, providing crucial information to describe and forecast solar magnetic activity indicators.

  9. [Differences in root developmenly of winter wheat cultivars in Huang-Huai Plain, China].

    Science.gov (United States)

    Qiu, Xin-Qiang; Gao, Yang; Li, Xin-Qiang; Huang, Ling; Duan, Ai-Wang

    2012-07-01

    Selecting one presently popularized winter wheat cultivar (Zhengmai 9023) and two cultivars (Abo and Fengchan 3) introduced in the 1950s and 1960s in Huang-Huai Plain as test materials, and by using minirhizotron technique, this paper studied the live root length, root diameter distribution, and net root growth rate of the cultivars. Fine roots with a diameter from 0.05 mm to 0.25 mm occupied the majority of the whole root system, and the fine roots with a diameter less than 0.5 mm accounted for 98% of the live root length. The average root diameter varied with plant growth, the variation range being 0.15 - 0.22 mm, and no significant difference was observe among the cultivars. The live root length was significantly positively correlated root number, suggesting that root number was the main factor for the increase of live root length. The most vigorous growth period of the roots was from reviving to jointing stage, and Abo and Fengchan 3 had a longer period increased root vitality, as compared with Zhengmai 9023. For Zhengmai 9023, its fine roots with a diameter more than 0.1 mm had an increasing proportion after jointing stage, which was helpful for improving plant resistance, root activity, and grain-filling at late growth stages.

  10. Multiple Harmonics Fitting Algorithms Applied to Periodic Signals Based on Hilbert-Huang Transform

    Directory of Open Access Journals (Sweden)

    Hui Wang

    2013-01-01

    Full Text Available A new generation of multipurpose measurement equipment is transforming the role of computers in instrumentation. The new features involve mixed devices, such as kinds of sensors, analog-to-digital and digital-to-analog converters, and digital signal processing techniques, that are able to substitute typical discrete instruments like multimeters and analyzers. Signal-processing applications frequently use least-squares (LS sine-fitting algorithms. Periodic signals may be interpreted as a sum of sine waves with multiple frequencies: the Fourier series. This paper describes a new sine fitting algorithm that is able to fit a multiharmonic acquired periodic signal. By means of a “sinusoidal wave” whose amplitude and phase are both transient, the “triangular wave” can be reconstructed on the basis of Hilbert-Huang transform (HHT. This method can be used to test effective number of bits (ENOBs of analog-to-digital converter (ADC, avoiding the trouble of selecting initial value of the parameters and working out the nonlinear equations. The simulation results show that the algorithm is precise and efficient. In the case of enough sampling points, even under the circumstances of low-resolution signal with the harmonic distortion existing, the root mean square (RMS error between the sampling data of original “triangular wave” and the corresponding points of fitting “sinusoidal wave” is marvelously small. That maybe means, under the circumstances of any periodic signal, that ENOBs of high-resolution ADC can be tested accurately.

  11. Novel pharmacokinetic studies of the Chinese formula Huang-Lian-Jie-Du-Tang in MCAO rats.

    Science.gov (United States)

    Zhu, Huaxu; Qian, Zhilei; He, Feng; Liu, Mengzhu; Pan, Linmei; Zhang, Qichun; Tang, Yuping

    2013-07-15

    Our previous studies showed that after oral administration of an Huang-Lian-Jie-Du-Tang (HLJDT) decoction, there is a higher concentration of the pure components, berberine, baicalin and gardenoside in the plasma of Middle cerebral artery occlusion (MCAO) rats than in sham-operated rats, The aim of the present study was to determine whether these components could be reliably measured in MCAO rat tissues. First, the plasma concentration-time profiles of berberine, palmatine, baicalin, baicalein and gardenoside were characterised in MCAO rats after oral administration of the aqueous extract of HLJDT. Subsequently, liver, lung and kidney tissues were obtained from sudden death MCAO rats in the absorption phase (0.25 h), the distribution phase (1.0 h) and the elimination phase (8.0 h) after administration of the HLJDT aqueous extract. An HPLC method was developed and validated for the determination of the distribution characteristics of berberine, palmatine, baicalin, baicalein and gardenoside simultaneously from the above-mentioned rat tissues. The results indicated that berberine, palmatine, baicalin and baicalein distributed rapidly and accumulated at high levels in the lung, while gardenoside distributed widely in the lung and the kidney. To the best of our knowledge, this is the first report to describe the distribution of the active ingredients derived from HLJDT in MCAO rat tissues. The tissue distribution results provide a biopharmaceutical basis for the design of the clinic application of HLJDT in cerebrovascular disease. Copyright © 2012 Elsevier GmbH. All rights reserved.

  12. NINJA data analysis with a detection pipeline based on the Hilbert-Huang transform

    International Nuclear Information System (INIS)

    Stroeer, Alexander; Camp, Jordan

    2009-01-01

    The NINJA data analysis challenge allowed the study of the sensitivity of data analysis pipelines to binary black hole numerical relativity waveforms in simulated Gaussian noise at the design level of the LIGO observatory and the VIRGO observatory. We analyzed NINJA data with a pipeline based on the Hilbert-Huang transform, utilizing a detection stage and a characterization stage: detection is performed by triggering on excess instantaneous power, characterization is performed by displaying the kernel density enhanced (KD) time-frequency trace of the signal. Using the simulated data based on the two LIGO detectors, we were able to detect 77 signals out of 126 above signal-to-noise ratio, SNR 5 in coincidence, with 43 missed events characterized by SNR < 10. Characterization of the detected signals revealed the merger part of the waveform in high time and frequency resolution, free from time-frequency uncertainty. We estimated the timelag of the signals between the detectors based on the optimal overlap of the individual KD time-frequency maps, yielding estimates accurate within a fraction of a millisecond for half of the events. A coherent addition of the data sets according to the estimated timelag eventually was used in a final characterization of the event.

  13. Bearing fault detection utilizing group delay and the Hilbert-Huang transform

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Shuai; Lee, Sang-Kwon [Inha University, Incheon (Korea, Republic of)

    2017-03-15

    Vibration signals measured from a mechanical system are useful to detect system faults. Signal processing has been used to extract fault information in bearing systems. However, a wide vibration signal frequency band often affects the ability to obtain the effective fault features. In addition, a few oscillation components are not useful at the entire frequency band in a vibration signal. By contrast, useful fatigue information can be embedded in the noise oscillation components. Thus, a method to estimate which frequency band contains fault information utilizing group delay was proposed in this paper. Group delay as a measure of phase distortion can indicate the phase structure relationship in the frequency domain between original (with noise) and denoising signals. We used the empirical mode decomposition of a Hilbert-Huang transform to sift the useful intrinsic mode functions based on the results of group delay after determining the valuable frequency band. Finally, envelope analysis and the energy distribution after the Hilbert transform were used to complete the fault diagnosis. The practical bearing fault data, which were divided into inner and outer race faults, were used to verify the efficiency and quality of the proposed method.

  14. Resolving the ambiguity in the relation between Stokes shift and Huang-Rhys parameter.

    Science.gov (United States)

    de Jong, Mathijs; Seijo, Luis; Meijerink, Andries; Rabouw, Freddy T

    2015-07-14

    Electronic transitions in luminescent molecules or centers in crystals couple to vibrations. This results in broadening of absorption and emission bands, as well as in the occurence of a Stokes shift EStokes. In principle, one can derive from EStokes the Huang-Rhys parameter S, which describes the microscopic details of the vibrational coupling and can be related to the equilibrium position offset ΔQe between the ground state and excited state. The commonly used textbook relations EStokes = (2S - 1)ℏω and EStokes = 2Sℏω are only approximately valid. In this paper we investigate how EStokes is related to S, taking into account the effects of a finite temperature. We show that in different ranges of temperature, different approximate relations between EStokes and S are appropriate. Moreover, we demonstrate that the difference between the barycenters of absorption and emission bands can be used to determine S in an unambiguous way. The position of the barycenter is, contrary to the Stokes shift, unaffected by temperature.

  15. Transient detection of eccentricity-related components in induction motors through the Hilbert-Huang Transform

    International Nuclear Information System (INIS)

    Antonino-Daviu, J.; Rodriguez, P. Jover; Riera-Guasp, M.; Arkkio, A.; Roger-Folch, J.; Perez, R.B.

    2009-01-01

    The identification and extraction of characteristic patterns are proposed in this work for the diagnosis and evaluation of mixed eccentricities in induction electrical machines with parallel stator branches. Whereas the classical diagnosis approaches, deeply spread in the industrial environment, are based on the Fourier analysis of the steady-state current, the basis of the proposed methodology consist of analysing the current demanded by the machine during the connection process (startup transient); the objective is to extract the characteristic evolution during the transient of some harmonic components created by the fault; this evolution is caused by the dependence of these components on the slip (s), a quantity varying during the startup transient from 1 to almost 0. For this feature extraction, the Hilbert-Huang Transform (HHT) is proposed. An analysis of the behaviour of this transform in comparison with another time-frequency approach used in other works, the Discrete Wavelet Transform (DWT), is also presented in the paper. The results show the usefulness of the methodology for the reliable diagnosis of the mixed eccentricity fault and for the correct discrimination against other types of failures.

  16. Lagrangian single-particle turbulent statistics through the Hilbert-Huang transform.

    Science.gov (United States)

    Huang, Yongxiang; Biferale, Luca; Calzavarini, Enrico; Sun, Chao; Toschi, Federico

    2013-04-01

    The Hilbert-Huang transform is applied to analyze single-particle Lagrangian velocity data from numerical simulations of hydrodynamic turbulence. The velocity trajectory is described in terms of a set of intrinsic mode functions C(i)(t) and of their instantaneous frequency ω(i)(t). On the basis of this decomposition we define the ω-conditioned statistical moments of the C(i) modes, named q-order Hilbert spectra (HS). We show that such quantities have enhanced scaling properties as compared to traditional Fourier transform- or correlation-based (structure functions) statistical indicators, thus providing better insights into the turbulent energy transfer process. We present clear empirical evidence that the energylike quantity, i.e., the second-order HS, displays a linear scaling in time in the inertial range, as expected from a dimensional analysis. We also measure high-order moment scaling exponents in a direct way, without resorting to the extended self-similarity procedure. This leads to an estimate of the Lagrangian structure function exponents which are consistent with the multifractal prediction in the Lagrangian frame as proposed by Biferale et al. [Phys. Rev. Lett. 93, 064502 (2004)].

  17. Comment on "Critique and correction of the currently accepted solution of the infinite spherical well in quantum mechanics" by Huang Young-Sea and Thomann Hans-Rudolph

    OpenAIRE

    Prados, A.; Plata, C. A.

    2016-01-01

    We comment on the paper "Critique and correction of the currently accepted solution of the infinite spherical well in quantum mechanics" by Huang Young-Sea and Thomann Hans-Rudolph, EPL 115, 60001 (2016) .

  18. Calcium supplements

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/007477.htm Calcium supplements To use the sharing features on this page, please enable JavaScript. WHO SHOULD TAKE CALCIUM SUPPLEMENTS? Calcium is an important mineral for the ...

  19. Fallow land mapping for better crop monitoring in Huang-Huai-Hai Plain using HJ-1 CCD data

    International Nuclear Information System (INIS)

    Zhang, Miao; Wu, Bingfang; Meng, Jihua; Dong, Taifeng; You, Xingzhi

    2014-01-01

    The prediction of grain production is essential for socio-economic development planning, guidance and control of macro cropping structure adjustment. Fallow areas should be identified each growing season which is critical for grain production prediction. This paper focuses on fallow arable land monitoring during summer grain season in the Huang-Huai-Hai Plain using China Environment Satellite HJ-1 CCD data. With the two satellites HJ-1A and HJ-1B, high temporal Normalized Difference Vegetation Index (NDVI) can be obtained. HJ-1 CCD data were acquired from early March to early June in 2010 over the Huang-Huai-Hai Plain. Multi-temporal HJ-1 CCD data were pre-processed and time series of NDVI were derived. An algorithm for separating cropped and fallow areas was developed based on three key periods of NDVI in early-March, mid-April and mid-May, 2010. The influence of fallow arable lands to yield estimation and crop condition monitoring over the Huang-Huai-Hai Plain were also investigated and analyzed. Preliminary results in this paper showed that HJ-1 CCD data are capable for fallow land monitoring. Information of fallow arable lands is an essential part of crop monitoring and it should be incorporated into crop monitoring systems. In the future, the fallow lands over autumn grain season should also be identified and information of fallow arable lands should be generated yearly in order to get more reliable production prediction

  20. SPORT SUPPLEMENTATION

    OpenAIRE

    Alexandаr Marinkov

    2016-01-01

    Sport supplementation is essential for athletes performance and achievements. The well balanced and structured supplementation is a challenge for sport medicine because must be done a balance between potential benefits and potential risks (anti-doping rule violations and others). In this review are structured the most used categories sport supplementations. Nutritional supplements used in sport could be divided in some main categories like: amino acids, vitamins, proteins and antioxidants. Fo...

  1. Anti-Ma2 antibody related paraneoplastic limbic/brain stem encephalitis associated with breast cancer expressing Ma1, Ma2, and Ma3 mRNAs.

    Science.gov (United States)

    Sahashi, K; Sakai, K; Mano, K; Hirose, G

    2003-09-01

    A 69 year old woman presented with cognitive impairment and supranuclear gaze palsy caused by paraneoplastic limbic/brain stem encephalitis associated with atypical medullary breast carcinoma. The cerebrospinal fluid from the patient harboured an anti-neuronal cell antibody against Ma2 antigen, but not against Ma1 or Ma3 antigen. Despite the antibody being restricted to the Ma2 antigen, the patient's cancer tissue expressed Ma1, Ma2, and Ma3 mRNAs. These results, and the expression of Ma2 mRNA in an atypical medullar breast carcinoma in another patient without paraneoplastic encephalitis, indicate that the induction of anti-Ma2 antibody depends on host immunoreponsiveness and not on the presence of the antigen itself in the cancer.

  2. Interdependence between damage indices and ground motion parameters based on Hilbert–Huang transform

    International Nuclear Information System (INIS)

    Alvanitopoulos, P F; Andreadis, I; Elenas, A

    2010-01-01

    Feature extraction from seismic accelerograms is a key issue in characterization of earthquake damage in structures. Until today, a number of effective classical parameters such as peak ground acceleration (PGA) and Arias intensity have been proposed for analyzing the earthquake motion records. The aim of this paper is to search for new crucial characteristic seismic parameters which provide information pertinent to the damage indicators of the structures. The first proposed parameter is the maximum amplitude (A HHT m ax ) and the second is the mean amplitude (A HHT m ean ). Emphasis of our work has been placed on the use of the Hilbert–Huang transform (HHT). A set of 13 natural accelerograms from worldwide well-known sites with strong seismic activity have been used. The HHT has been applied to the nonlinear and non-stationary data (earthquake recordings). Each complex seismic accelerogram is decomposed into several simple components called intrinsic mode functions (IMFs). Using the IMFs a three-dimensional time–frequency distribution of earthquake excitation is computed and two new seismic parameters are proposed and evaluated. After the numerical computation of all the seismic parameters (classical and proposed), nonlinear dynamic analysis is carried out to provide the post-seismic damage status of the structure under study. Two structural damage indices are utilized and the degree of interrelation among them and the seismic parameters is provided by correlation coefficients. Furthermore, two different reinforced concrete structures are examined. Results indicate the high correlation of the new seismic parameters (A HHT m ax , A HHT m ean ) with the damage indices and confirm that HHT is a promising tool for extracting information to characterize damage in structures

  3. Evaluation of the Antioxidant and Melanogenesis Inhibitory Properties of Pracparatum Mungo (Lu-Do Huang

    Directory of Open Access Journals (Sweden)

    Yu-Yu Kao

    2013-07-01

    Full Text Available Pracparatum mungo (Lu-Do Huang is a traditional Chinese functional medicine made from the natural fermentation of mung bean (綠豆 Lǜ Dòu mixed with other Chinese medicines. It has been recognized as having liver protecting and detoxifying effects. As mung beans have been verified to possess anti-inflammatory, antioxidant, antipyretic, and whitening actions, the present research utilized the in vitro, ex vivo, and in vivo experimental models to investigate the antioxidant and melanin inhibiting effects of P. mungo on the skin. The in vitro experiment revealed that P. mungo methanol extract (PMME and P. mungo ethanol extract (PMEE possess the capacity to clear α,α-diphenyl-2-picrylhydrazyl (DPPH radicals and inhibit tyrosinase activity. The ex vivo experiment indicated that PMEE can promote the growth of MDCK cells and increase the enzymatic activities of superoxide dismutase (SOD and catalase in MDCK cells. On the other hand, PMME and PMEE can suppress the proliferation of A375 cells, and PMEE can reduce the enzymatic activities of SOD and catalase in A375 cells. The in vivo results showed that P. mungo can enhance the enzymatic performance of SOD, Catalase, and glutathione peroxidase (GPx in the liver. The results also showed that P. mungo has antioxidant characteristics and can inhibit tyrosinase activity, thereby promoting the growth of skin tissues and suppressing the proliferation of A375 cells, and thus enhancing the effects that the antioxidant enzymatic performance has on the liver. These results can be applied in the development of tyrosinase inhibitors or antioxidants used for the inhibition of melanin biosynthesis or for auto-oxidation in further industrial applications, particularly those relating to functional food or cosmetic compositions.

  4. BaMa / Raivo Juurak

    Index Scriptorium Estoniae

    Juurak, Raivo, 1949-

    2002-01-01

    Eesti ülikoolide üleminekust 3+2 süsteemile. Lühend BaMa on tulnud kasutusele seoses Euroopa ülikoolide õppekavade reformimisega ning tähistab õppekava, kus esimese astme läbimise järel omandatakse bakalaureuse- ja teise järel magistrikraad. Õppekavade tüüpidest Eesti ja Euroopa Liidu kõrgkoolides ning Bologna deklaratsioonist

  5. 42 CFR 495.202 - Identification of qualifying MA organizations, MA-EPs and MA-affiliated eligible hospitals.

    Science.gov (United States)

    2010-10-01

    ... qualifying MA-affiliated eligible hospitals under the MA EHR incentive program are required to identify...-EPs and MA-affiliated eligible hospitals. 495.202 Section 495.202 Public Health CENTERS FOR MEDICARE... STANDARDS FOR THE ELECTRONIC HEALTH RECORD TECHNOLOGY INCENTIVE PROGRAM Requirements Specific to Medicare...

  6. Supplemental Colleges

    Data.gov (United States)

    Department of Homeland Security — The Supplemental Colleges layer attempts to capture additional Post Secondary Education campuses of colleges and universities associated with a single campus listed...

  7. Huang's three-step maneuver shortens the learning curve of laparoscopic spleen-preserving splenic hilar lymphadenectomy.

    Science.gov (United States)

    Huang, Chang-Ming; Huang, Ze-Ning; Zheng, Chao-Hui; Li, Ping; Xie, Jian-Wei; Wang, Jia-Bin; Lin, Jian-Xian; Jun, Lu; Chen, Qi-Yue; Cao, Long-Long; Lin, Mi; Tu, Ru-Hong

    2017-12-01

    The goal of this study was to investigate the difference between the learning curves of different maneuvers in laparoscopic spleen-preserving splenic hilar lymphadenectomy for advanced upper gastric cancer. From January 2010 to April 2014, 53 consecutive patients who underwent laparoscopic spleen-preserving splenic hilar lymphadenectomy via the traditional-step maneuver (group A) and 53 consecutive patients via Huang's three-step maneuver (group B) were retrospectively analyzed. No significant difference in patient characteristics were found between the two groups. The learning curves of groups A and B were divided into phase 1 (1-43 cases and 1-30 cases, respectively) and phase 2 (44-53 cases and 31-53 cases, respectively). Compared with group A, the dissection time, bleeding loss and vascular injury were significantly decreased in group B. No significant differences in short-term outcomes were found between the two maneuvers. The multivariate analysis indicated that the body mass index, short gastric vessels, splenic artery type and maneuver were significantly associated with the dissection time in group B. No significant difference in the survival curve was found between the maneuvers. The learning curve of Huang's three-step maneuver was shorter than that of the traditional-step maneuver, and the former represents an ideal maneuver for laparoscopic spleen-preserving splenic hilar lymphadenectomy.To shorten the learning curve at the beginning of laparoscopic spleen-preserving splenic hilar lymphadenectomy, beginners should beneficially use Huang's three-step maneuver and select patients with advanced upper gastric cancer with a body mass index of less than 25 kg/m 2 and the concentrated type of splenic artery. Copyright © 2017. Published by Elsevier Ltd.

  8. Hilbert-Huang transform based instrumental assessment of intention tremor in multiple sclerosis

    Science.gov (United States)

    Carpinella, Ilaria; Cattaneo, Davide; Ferrarin, Maurizio

    2015-08-01

    Objective. This paper describes a method to extract upper limb intention tremor from gyroscope data, through the Hilbert-Huang transform (HHT), a technique suitable for the study of nonlinear and non-stationary processes. The aims of the study were to: (i) evaluate the method’s ability to discriminate between healthy controls and MS subjects; (ii) validate the proposed procedure against clinical tremor scores assigned using Fahn’s tremor rating scale (FTRS); and (iii) compare the performance of the HHT-based method with that of linear band-pass filters. Approach. HHT was applied on gyroscope data collected on 20 MS subjects and 13 healthy controls (CO) during finger-to-nose tests (FNTs) instrumented with an inertial sensor placed on the hand. The results were compared to those obtained after traditional linear filtering. The tremor amplitude was quantified with instrumental indexes (TIs) and clinical FTRS ratings. Main results. The TIs computed after HHT-based filtering discriminated between CO and MS subjects with clinically-detected intention tremor (MS_T). In particular, TIs were significantly higher in the final part of the movement (TI2) with respect to the first part (TI1), and, for all components (X, Y, Z), MST showed a TI2 significantly higher than in CO subjects. Moreover, the HHT detected subtle alterations not visible from clinical ratings, as TI2 (Z-component) was significantly increased in MS subjects without clinically-detected tremor (MS_NT). The method’s validity was demonstrated by significant correlations between clinical FTRS scores and TI2 related to X (rs = 0.587, p = 0.006) and Y (rs = 0.682, p < 0.001) components. Contrarily, fewer differences among the groups and no correlation between instrumental and clinical indexes emerged after traditional filtering. Significance. The present results supported the use of the HHT-based procedure for a fully-automated quantitative and objective measure of intention tremor in MS, which can overcome

  9. Effects of Huang Bai (Phellodendri Cortex and Three Other Herbs on GnRH and GH Levels in GT1–7 and GH3 Cells

    Directory of Open Access Journals (Sweden)

    Sun Haeng Lee

    2016-01-01

    Full Text Available The present study was to evaluate the effects of Huang Bai, Zhi Mu, Mai Ya, and Xia Ku Cao on hormone using the GT1–7 and GH3 cells. The GT1–7 and GH3 cell lines were incubated with DW; DMSO; and 30, 100, or 300 μg/mL of one of the four extract solutions in serum-free media for 24 hours. The MTT assay was performed to determine the cytotoxicity of the four herbs. The GT1–7 and GH3 cells were incubated in DW, estradiol (GT1–7 only, or noncytotoxic herb solutions in serum-free medium for 24 hours. A quantitative RT-PCR and western blot were performed to measure the GnRH expression in GT1–7 cells and GH expression in GH3 cells. Huang Bai, Zhi Mu, Xia Ku Cao, and Mai Ya inhibited the GnRH mRNA expression in GT1–7 cells, whereas Huang Bai enhanced GH mRNA expression in GH3 cells. Additionally, Xia Ku Cao inhibited GnRH protein expression in GT1–7 cells and Huang Bai promoted GH protein expression in GH3 cells. The findings suggest that Huang Bai can delay puberty by inhibiting GnRH synthesis in the hypothalamus while also accelerating growth by promoting GH synthesis and secretion in the pituitary.

  10. Anti-Ma and anti-Ma2-associated paraneoplastic neurological syndromes.

    Science.gov (United States)

    Ortega Suero, G; Sola-Valls, N; Escudero, D; Saiz, A; Graus, F

    Analyse the clinical profile, associated tumour types, and response to treatment of paraneoplastic neurological syndromes associated with antibodies against Ma proteins. A retrospective study of patients with antibodies against Ma proteins identified in a neuroimmunology laboratory of reference. Of the 32 patients identified, 20 showed reactivity against Ma2 only (anti-Ma2 antibodies), 11 against Ma1 and Ma2 (anti-Ma antibodies), and 1 with reactivity against Ma1 only (anti-Ma1 antibodies). The most common clinical presentations were limbic encephalopathy, diencephalic dysfunction, or brainstem encephalopathy, frequently appearing as a combination of these features. Three patients had isolated cerebellar dysfunction with anti-Ma antibodies, and 2 exhibited peripheral nervous system syndrome with anti-Ma2 antibodies. Testicular tumours were the most common neoplasms (40%) in the anti-Ma2 cases. In the group associated with anti-Ma1 antibodies, the most common were lung tumours (36%), followed by testicular tumours. All idiopathic cases were reactive to Ma2. The clinical outcome was significantly better in the anti-Ma2 group. The patient with anti-Ma1 presented with limbic encephalitis and brainstem dysfunction associated with lymphoepithelioma of the bladder. Specifically determining the different reactivities of anti-Ma protein antibodies in order to differentiate between Ma1 and Ma2 antibodies is important because anti-Ma2-associated paraneoplastic syndromes have a better outcome. Lastly, this study is the first to confirm that there may be cases that react exclusively to antibodies against Ma1. Copyright © 2016 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  11. 33 CFR 80.135 - Hull, MA to Race Point, MA.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Hull, MA to Race Point, MA. 80... INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.135 Hull, MA to Race Point, MA. (a... the east coast of Massachusetts from the easternmost radio tower at Hull, charted in approximate...

  12. Obama vu de ma banlieue.

    Directory of Open Access Journals (Sweden)

    Olga Stanislawska

    2008-12-01

    Full Text Available Une petite brocante est organisée tous les jeudis sur une place proche de la Basilique de Saint-Denis. On y vend des livres, des bibelots, des bijoux fantaisies et des masques africains. L’un des vendeurs a visiblement décidé de bénéficier de l’effet Obama. J’ai pris la photo de ma fenêtre, située au dessus de ce marché. J’ai adoré ce stand, mais ce n’est qu’une fois sur l’écran de mon ordinateur que j’ai vu les petites images Banania... ! Si j’avais su, je serais ...

  13. Oral Astragalus (Huang qi) for preventing frequent episodes of acute respiratory tract infection in children.

    Science.gov (United States)

    Su, Guobin; Chen, Xiankun; Liu, Zhuangzhu; Yang, Lihong; Zhang, La; Stålsby Lundborg, Cecilia; Wen, Zehuai; Guo, Xinfeng; Qin, Xindong; Liang, Jueyao; Liu, Xusheng

    2016-12-01

    Acute respiratory tract infections (ARTIs) are common in children and can involve both upper and lower airways. Many children experience frequent ARTI episodes or recurrent respiratory tract infections (RRTIs) in early life, which creates challenges for paediatricians, primary care physicians, parents and carers of children.In China, Astragalus (Huang qi), alone or in combination with other herbs, is used by Traditional Chinese Medicine (TCM) practitioners in the form of a water extract, to reduce the risk of ARTIs; it is believed to stimulate the immune system. Better understanding of the therapeutic mechanisms of Astragalus may provide insights into ARTI prevention, and consequently reduced antibiotic use. To assess the effectiveness and safety of oral Astragalus for preventing frequent episodes of acute respiratory tract infections (ARTIs) in children in community settings. We searched the Cochrane Central Register of Controlled Trials (CENTRAL, Issue 12, 2015), MEDLINE (Ovid) (1946 to 31 December 2015), Embase (Elsevier) (1974 to 31 December 2015), AMED (Ovid) (1985 to 31 December 2015), Chinese National Knowledge Infrastructure (CNKI) (1979 to 31 December 2015) and Chinese Scientific Journals full text database (CQVIP) (1989 to 31 December 2015), China Biology Medicine disc (CBM 1976 to 31 December 2015) and Wanfang Data Knowledge Service Platform (WanFang) (1998 to 31 December 2015). We included randomised controlled trials (RCTs) comparing oral Astragalus as a sole Chinese herbal preparation with placebo to prevent frequent episodes of ARTIs in children. We used standard Cochrane methodological procedures for this review. We assessed search results to identify relevant studies. We planned to extract data using standardised forms. Disagreements were to be resolved through discussion. Risk of bias was to be assessed using the Cochrane 'Risk of bias' tool. We planned to use mean difference (MD) or standardised mean difference (SMD) for continuous data and risk

  14. Nutritional supplements

    DEFF Research Database (Denmark)

    Petersen, Gry Bjerg; Andersen, Jens Rikardt

    2015-01-01

    Background: Several studies have indicated that cancer patients have significantly altered taste sensitivity without specifying the preferences. One of the related problems is low compliance to nutritional therapy with oral nutritional supplements (ONS) in patients suffering severe weight loss...

  15. Supplemental information

    Data.gov (United States)

    U.S. Environmental Protection Agency — Supplemental information showing results of inter-comparison between C-PORT, AERMOD and R-LINE dispersion algorithms. This dataset is associated with the following...

  16. Midazolam induces apoptosis in MA-10 mouse Leydig tumor cells through caspase activation and the involvement of MAPK signaling pathway

    Directory of Open Access Journals (Sweden)

    So EC

    2014-02-01

    Full Text Available Edmund Cheung So,1,2 Yu-Xuan Lin,3 Chi Hao Tseng,1 Bo-Syong Pan,3 Ka-Shun Cheng,2 Kar-Lok Wong,2 Lyh-Jyh Hao,4 Yang-Kao Wang,5 Bu-Miin Huang2 1Department of Anesthesia, Tainan Municipal An Nan Hospital, China Medical University, Tainan, Taiwan; 2Department of Anesthesia, China Medical University, Taichung, Taiwan; 3Department of Cell Biology and Anatomy, National Cheng Kung University, Tainan, Taiwan; 4Department of Internal Medicine, Division of Endocrinology and Metabolism, Kaohsiung Veteran General Hospital Tainan Branch Tainan, Taiwan; 5Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei, Taiwan Purpose: The present study aims to investigate how midazolam, a sedative drug for clinical use with cytotoxicity on neuronal and peripheral tissues, induced apoptosis in MA-10 mouse Leydig tumor cells. Methods: The apoptotic effect and underlying mechanism of midazolam to MA-10 cells were investigated by flow cytometry assay and Western blotting methods. Results: Data showed that midazolam induced the accumulation of the MA-10 cell population in the sub-G1 phase and a reduction in the G2/M phase in a time- and dose-dependent manner, suggesting an apoptotic phenomenon. Midazolam could also induce the activation of caspase-8, -9, and -3 and poly (ADP-ribose polymerase proteins. There were no changes in the levels of Bax and cytochrome-c, whereas Bid was significantly decreased after midazolam treatment. Moreover, midazolam decreased both pAkt and Akt expression. In addition, midazolam stimulated the phosphorylation of p38 and c-Jun NH2-terminal kinase but not extracellular signal-regulated kinase. Conclusion: Midazolam could induce MA-10 cell apoptosis through the activation of caspase cascade, the inhibition of pAkt pathway, and the induction of p38 and c-Jun NH2-terminal kinase pathways. Keywords: midazolam, apoptosis, MA-10 cell, caspase, Akt, MAPKs

  17. [Realization of Heart Sound Envelope Extraction Implemented on LabVIEW Based on Hilbert-Huang Transform].

    Science.gov (United States)

    Tan, Zhixiang; Zhang, Yi; Zeng, Deping; Wang, Hua

    2015-04-01

    We proposed a research of a heart sound envelope extraction system in this paper. The system was implemented on LabVIEW based on the Hilbert-Huang transform (HHT). We firstly used the sound card to collect the heart sound, and then implemented the complete system program of signal acquisition, pretreatment and envelope extraction on LabVIEW based on the theory of HHT. Finally, we used a case to prove that the system could collect heart sound, preprocess and extract the envelope easily. The system was better to retain and show the characteristics of heart sound envelope, and its program and methods were important to other researches, such as those on the vibration and voice, etc.

  18. Metabolomic Assessment of Acute Cholestatic Injuries Induced by Thioacetamide and by Bile Duct Ligation, and the Protective Effects of Huang-Lian-Jie-Du-Decoction

    Directory of Open Access Journals (Sweden)

    Dan-Dan Wei

    2018-05-01

    Full Text Available Huang-Lian-Jie-Du-Decoction, a traditional Chinese formula, has been reported to protect liver from various injuries. Two cholestasis models of rats induced by thioacetamide and by bile duct ligation were established and treated with Huang-Lian-Jie-Du-Decoction. Nuclear Magnetic Resonance-based urinary metabolic profiles were analyzed by orthogonal partial least squares discriminant analysis and univariate analysis to excavate differential metabolites associated with the injuries of the two models and the treatment effects of Huang-Lian-Jie-Du-Decoction. The two cholestatic models shared common metabolic features of excessive fatty acid oxidation, insufficient glutathione regeneration and disturbed gut flora, with specific characteristics of inhibited urea cycle and DNA damage in thioacetamide-intoxicated model, and perturbed Kreb's cycle and inhibited branched chain amino acid oxidation in bile duct ligation model. With good treatment effects, Huang-Lian-Jie-Du-Decoction could regain the balance of the disturbed metabolic status common in the two cholestasis injuries, e.g., unbalanced redox system and disturbed gut flora; and perturbed urea cycle in thioacetamide-intoxicated model and energy crisis (disturbed Kreb's cycle and oxidation of branched chain amino acid in bile duct ligation model, respectively.

  19. Enhancing MA transmutation by irradiation of (MA, Zr)Hx in FBR blanket region - 5383

    International Nuclear Information System (INIS)

    Konashi, K.; Ikeda, K.; Itoh, K.; Hirai, M.; Koyama, T.; Kurosaki, K.

    2015-01-01

    Minor actinide (MA) hydride is proposed as transmutation target in sodium-cooled mixed oxide fuelled fast reactor. Preliminarily calculations have been done to check the transmutation efficiency of MA hydride targets. Three different types of MA target, MA-Zr alloy, (MA, Zr)O 2 and (MA, Zr)H x , have been compared on MA transmutation rate. The targets are assumed to be loaded around an active core in a 280 MWe sodium-cooled reactor; 54 MA target assemblies are respectively arranged in a row in the radial blanket zone. They are supposed to be irradiated for one year and then be cooled for 60 days. The transmuted mass has been evaluated by three-dimensional diffusion calculation to be 25, 15, 61 kg/EFPY for the alloy, the oxide and the hydride respectively, where production of MA in the active core is taken into account. The transmutation mass by (MA, Zr)H x is much larger than those by the other types of targets, while the core characteristics remain sound by locating MA targets outside of the active core. On top of that, two kinds of (MA, Zr)O 2 targets which are combined with ZrH x (x=1.7) pins have been calculated. Major Research/Development items are selected to establish the MA hydride transmutation method by reviewing technologies applicable to the transmutation system. The practical use of the MA hydride transmutation method is not far ahead technically, since this method can be developed by the extension of existing technologies. (authors)

  20. Ma olin Saddami poeg / Latif Jahija

    Index Scriptorium Estoniae

    Jahija, Latif

    1995-01-01

    Järg Jan/21.,28. lk. 7,5. L. Jahija sensatsiooniline raamat "Ma olin Saddami poeg", milles ta pajatab kuidas ta a. 1987-1991 oli Iraagi presidendi vanema poja teisik. Lühikokkuvõte sellest jutustusest

  1. FuSuMaTech workshop

    CERN Multimedia

    Olofsson, Simon

    2018-01-01

    The goal of the FuSuMaTecH IP workshop, organised at CERN Ideaquare 19-20 April, was to educate superconductivity and magnet experts about intellectual property. About 30 participants from multiple institutes and companies worked together in this two day interactive program which was facilitated by CERN Knowledge Transfer. Great progress was made in shaping the FuSuMaTech industrial demonstrator projects as well as the R&D&I subjects.

  2. [Ma2 antibody and multiple mononeuropathies].

    Science.gov (United States)

    Ayrignac, X; Castelnovo, G; Landrault, E; Fayolle, H; Pers, Y-M; Honnorat, J; Campello, C; Figarella-Branger, D; Labauge, P

    2008-01-01

    Anti-Ma2 antibodies belong to a family of onconeuronal antibodies that target proteins expressed in brain, testis and several tumors. Previously observed in patients presenting with limbic encephalitis, they seem to be associated with several other paraneoplastic syndromes. We report the case of a 73-year-old woman presenting sensory and motor neuropathy associated with non-small-cell lung cancer who had Ma2-antibodies.

  3. Apoptotic effect of cordycepin combined with cisplatin and/or paclitaxel on MA-10 mouse Leydig tumor cells

    Directory of Open Access Journals (Sweden)

    Kang FC

    2015-09-01

    Full Text Available Fu-Chi Kang,1 Pei-Jung Chen,2 Bo-Syong Pan,2,3 Meng-Shao Lai,2,3 Yung-Chia Chen,4 Bu-Miin Huang2,31Department of Anesthesia, Chi Mei Medical Center, Chiali, 2Department of Cell Biology and Anatomy, 3Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 4Department of Anatomy, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China Background: Chemotherapy is not limited to a single treatment, and the evidence demonstrates that different drug combinations can have positive results in patients. In this study, we sought to determine whether cordycepin combined with cisplatin and/or paclitaxel would have an additive effective on inducing apoptosis in mouse Leydig tumor cells, and the mechanisms were also briefly examined.Methods: The additive effects of cordycepin combined with cisplatin and/or paclitaxel on apoptosis in MA-10 cells were investigated by monitoring changes in morphological characteristics and examining cell viability, flow cytometry assays, and Western blot analyses.Results: Combination of cordycepin plus cisplatin and/or paclitaxel for 12 and 24 hours induced apoptotic features in MA-10 cells. The MTT assay showed that the combination treatment reduced the viability of MA-10 cells in a dose-dependent manner, with additive effects. Cell cycle analysis showed that combination treatment significantly increased subG1 phase cell numbers in MA-10 cells, indicating apoptosis. Moreover, cordycepin plus cisplatin and/or paclitaxel significantly induced cleavage of caspase-8, caspase-9, caspase-3, and poly ADP-ribose polymerase, and phosphorylation of c-Jun NH2-terminal kinase, extracellular signal-regulated kinase, p38, and p53 proteins in MA-10 cells.Conclusion: Cordycepin plus cisplatin and/or paclitaxel can have an additive effect on apoptosis in MA-10 cells, with activation of caspase, mitogen-activated protein kinase, and p53 signal pathways. Keywords: cordycepin

  4. Anti Ma2-associated myeloradiculopathy: expanding the phenotype of anti-Ma2 associated paraneoplastic syndromes

    OpenAIRE

    Murphy, Sinead M; Khan, Usman; Alifrangis, Constantine; Hazell, Steven; Hrouda, David; Blake, Julian; Ball, Joanna; Gabriel, Carolyn; Markarian, Pierre; Rees, Jeremy; Karim, Abid; Seckl, Michael J; Lunn, Michael P; Reilly, Mary M

    2011-01-01

    Anti-Ma2 associated paraneoplastic syndrome usually presents as limbic encephalitis in association with testicular tumours.1, 2 Only four patients have been reported with involvement outside the CNS, two of whom also had limbic or brainstem encephalitis.2, 3 We report a man with anti- Ma2 associated myeloradiculopathy and previous testicular cancer whose neurological syndrome stabilised and anti-Ma2 titres fell following orchidectomy of a microscopically normal testis.

  5. [Genetic improvement of cotton varieties in Huang-Huai region in China since 1950's. III. Improvement on agronomy properties, disease resistance and stability].

    Science.gov (United States)

    Jiang, B G; Kong, F L; Zhang, Q Y; Yang, F X; Jiang, R Q

    2000-01-01

    Data from a set of 5-location and 2-year experiments on 10 representative historical cotton varieties and the data of Huang-Huai Regional Cotton Trials from 1973 to 1996 were analyzed to estimate the effects of genetic improvement in agronomy properties, disease resistance and stability of cotton in Huang-Huai Region in China. The results indicated that a great genetic progress of earliness and disease resistance had been achieved by breeding programs since 1950's. The maturity was shortened 3-5 days; The rate of preforst yield was increased about 7 percentages. The problem of resistance to Fususium wilt has been solved and the resistance to Verticillum wilt was improving. Some progress in stability of cotton varieties also has been achieved by breeding programs since 1950.

  6. A time-frequency analysis method to obtain stable estimates of magnetotelluric response function based on Hilbert-Huang transform

    Science.gov (United States)

    Cai, Jianhua

    2017-05-01

    The time-frequency analysis method represents signal as a function of time and frequency, and it is considered a powerful tool for handling arbitrary non-stationary time series by using instantaneous frequency and instantaneous amplitude. It also provides a possible alternative to the analysis of the non-stationary magnetotelluric (MT) signal. Based on the Hilbert-Huang transform (HHT), a time-frequency analysis method is proposed to obtain stable estimates of the magnetotelluric response function. In contrast to conventional methods, the response function estimation is performed in the time-frequency domain using instantaneous spectra rather than in the frequency domain, which allows for imaging the response parameter content as a function of time and frequency. The theory of the method is presented and the mathematical model and calculation procedure, which are used to estimate response function based on HHT time-frequency spectrum, are discussed. To evaluate the results, response function estimates are compared with estimates from a standard MT data processing method based on the Fourier transform. All results show that apparent resistivities and phases, which are calculated from the HHT time-frequency method, are generally more stable and reliable than those determined from the simple Fourier analysis. The proposed method overcomes the drawbacks of the traditional Fourier methods, and the resulting parameter minimises the estimation bias caused by the non-stationary characteristics of the MT data.

  7. [Diversity of soil fauna in corn fields in Huang-Huai-Hai Plain of China under effects of conservation tillage].

    Science.gov (United States)

    Zhu, Qiang-Gen; Zhu, An-Ning; Zhang, Jia-Bao; Zhang, Huan-Chao; Huang, Ping; Zhang, Cong-Zhi

    2009-10-01

    An investigation was made on the abundance and diversity of soil fauna in the corn fields under conventional and conservation tillage in Huang-Huai-Hai Plain of China. The abundance and diversity of soil fauna were higher at corn maturing (September) than at its jointing stage (July), and higher at jointing stage under conservation tillage than under conventional tillage. Soil fauna mainly distributed in surface soil layer (0-10 cm), but still had a larger number in 10-20 cm layer under conservation tillage. The individuals of acari, diptera, diplura, and microdrile oligochaetes, especially those of acari, were higher under conservation tillage than under conventional tillage. At maturing stage, an obvious effect of straw-returning under conservation tillage was observed, i. e., the more the straw returned, the higher the abundance of soil fauna, among which, the individuals of collembola, acari, coleopteran, and psocoptera, especially those of collembolan, increased significantly. The abundance of collembola at both jointing and maturing stages was significantly positively correlated with the quantity of straw returned, suggesting that collembola played an important role in straw decomposition and nutrient cycling.

  8. The Anti-Inflammatory Effects of a Yin Zhi Huang Soup in an Experimental Autoimmune Prostatitis Rat Model

    Directory of Open Access Journals (Sweden)

    Longsheng Deng

    2017-01-01

    Full Text Available The present study aimed to investigate the therapeutic effects of the Chinese herbal medicine Yin Zhi Huang soup (YZS in an experimental autoimmune prostatitis (EAP rat model. In total, 48 rats were randomly divided into the following four groups (n=12/group: saline group, pathological model group, Qianlietai group, and YZS group. We determined the average wet weight of the prostate tissue, the ratio of the wet weight of the prostate tissue to body weight, tumor necrosis factor-alpha (TNF-α levels in the blood serum, the expression of inducible nitric oxide synthase (iNOS in the rats’ prostate tissues, and the pathological changes in the prostate tissue using light microscopy. YZS reduced the rats’ prostate wet weight, the ratio of the prostate wet weight to body weight, and TNF-α levels in the blood serum and inhibited the expression of iNOS in the rats’ prostate tissues (P<0.05. Following YZS treatment, the pathological changes in the rats’ prostates were improved compared with those in the model group (P<0.05. Furthermore, YZS treatment reduced inflammatory changes in the prostate tissue. It also significantly suppressed proinflammatory cytokines, such as TNF-α, and chemokines, such as iNOS, in the rat model of EAP.

  9. The Hilbert-Huang Transform-Based Denoising Method for the TEM Response of a PRBS Source Signal

    Science.gov (United States)

    Hai, Li; Guo-qiang, Xue; Pan, Zhao; Hua-sen, Zhong; Khan, Muhammad Younis

    2016-08-01

    The denoising process is critical in processing transient electromagnetic (TEM) sounding data. For the full waveform pseudo-random binary sequences (PRBS) response, an inadequate noise estimation may result in an erroneous interpretation. We consider the Hilbert-Huang transform (HHT) and its application to suppress the noise in the PRBS response. The focus is on the thresholding scheme to suppress the noise and the analysis of the signal based on its Hilbert time-frequency representation. The method first decomposes the signal into the intrinsic mode function, and then, inspired by the thresholding scheme in wavelet analysis; an adaptive and interval thresholding is conducted to set to zero all the components in intrinsic mode function which are lower than a threshold related to the noise level. The algorithm is based on the characteristic of the PRBS response. The HHT-based denoising scheme is tested on the synthetic and field data with the different noise levels. The result shows that the proposed method has a good capability in denoising and detail preservation.

  10. Assessment of vocal cord nodules: a case study in speech processing by using Hilbert-Huang Transform

    Science.gov (United States)

    Civera, M.; Filosi, C. M.; Pugno, N. M.; Silvestrini, M.; Surace, C.; Worden, K.

    2017-05-01

    Vocal cord nodules represent a pathological condition for which the growth of unnatural masses on vocal folds affects the patients. Among other effects, changes in the vocal cords’ overall mass and stiffness alter their vibratory behaviour, thus changing the vocal emission generated by them. This causes dysphonia, i.e. abnormalities in the patients’ voice, which can be analysed and inspected via audio signals. However, the evaluation of voice condition through speech processing is not a trivial task, as standard methods based on the Fourier Transform, fail to fit the non-stationary nature of vocal signals. In this study, four audio tracks, provided by a volunteer patient, whose vocal fold nodules have been surgically removed, were analysed using a relatively new technique: the Hilbert-Huang Transform (HHT) via Empirical Mode Decomposition (EMD); specifically, by using the CEEMDAN (Complete Ensemble EMD with Adaptive Noise) algorithm. This method has been applied here to speech signals, which were recorded before removal surgery and during convalescence, to investigate specific trends. Possibilities offered by the HHT are exposed, but also some limitations of decomposing the signals into so-called intrinsic mode functions (IMFs) are highlighted. The results of these preliminary studies are intended to be a basis for the development of new viable alternatives to the softwares currently used for the analysis and evaluation of pathological voice.

  11. Spatiotemporal Variation and Abrupt Change Analysis of Temperature from 1960 to 2012 in the Huang-Huai-Hai Plain, China

    Directory of Open Access Journals (Sweden)

    Yanyu Yin

    2015-01-01

    Full Text Available Based on a monthly dataset of temperature time series (1960–2012 in the Huang-Huai-Hai Plain of China (HHHPC, spatiotemporal variation and abrupt change analysis of temperature were examined by moving average, linear regression, spline interpolation, Mann-Kendall test, and moving t-test. Major conclusions were listed as follows. (1 Annual and seasonal temperature increased with different rates on the process of fluctuating changes during 1960~2012. The upward trend was 0.22°C 10a−1 for annual temperature, while it was very significant in winter (0.34°C 10a−1 and spring (0.31°C 10a−1, moderately significant in autumn (0.21°C 10a−1, and nonsignificant in summer (0.05°C 10a−1. (2 The spatial changes of annual and seasonal temperature were similar. The temperature increased significantly in Beijing and its adjacent regions, while it was nonsignificant in the central and southern regions. (3 The spring, autumn, winter, and annual temperature had warm abrupt change. The abrupt change time for winter temperature was in the late 1970s, while it was in the late 1980s and early 1990s for spring, autumn, and annual temperature. (4 Macroscopic effects of global and regional climate warming and human activities were probably responsible for the temperature changes. The climate warming would influence the hydrological cycle and agricultural crops in the study area.

  12. Feature Extraction and Classification of EHG between Pregnancy and Labour Group Using Hilbert-Huang Transform and Extreme Learning Machine

    Directory of Open Access Journals (Sweden)

    Lili Chen

    2017-01-01

    Full Text Available Preterm birth (PTB is the leading cause of perinatal mortality and long-term morbidity, which results in significant health and economic problems. The early detection of PTB has great significance for its prevention. The electrohysterogram (EHG related to uterine contraction is a noninvasive, real-time, and automatic novel technology which can be used to detect, diagnose, or predict PTB. This paper presents a method for feature extraction and classification of EHG between pregnancy and labour group, based on Hilbert-Huang transform (HHT and extreme learning machine (ELM. For each sample, each channel was decomposed into a set of intrinsic mode functions (IMFs using empirical mode decomposition (EMD. Then, the Hilbert transform was applied to IMF to obtain analytic function. The maximum amplitude of analytic function was extracted as feature. The identification model was constructed based on ELM. Experimental results reveal that the best classification performance of the proposed method can reach an accuracy of 88.00%, a sensitivity of 91.30%, and a specificity of 85.19%. The area under receiver operating characteristic (ROC curve is 0.88. Finally, experimental results indicate that the method developed in this work could be effective in the classification of EHG between pregnancy and labour group.

  13. Integrated pharmacokinetics of major bioactive components in MCAO rats after oral administration of Huang-Lian-Jie-Du-Tang.

    Science.gov (United States)

    Zhu, Huaxu; Qian, Zhilei; Li, Huan; Guo, Liwei; Pan, Linmei; Zhang, Qichun; Tang, Yuping

    2012-05-07

    Huang-Lian-Jie-Du-Tang (HLJDT, or Oren-gedoku-to in Japanese), an important multi-herb remedy in China and other Asia countries, has been used clinically to treat cerebral ischemia for decades. According to the previous studies we have reported, an HPLC method was developed and validated for determination of berberine, palmatine, baicalin, baicalein and geniposide simultaneously in MCAO rat plasma after administration of HLJDT aqueous extract. A classified integral pharmacokinetic method was put forward after having compared the integrated concentration-time profile with that of single component. An AUC based weighting approach was used for integrated principle. The results indicated the classified integral pharmacokinetic profile of index components from HLJDT could reveal the pharmacokinetic behavior of original components, and was corresponding to the holistic pharmacological effects of anti-ischemia with HLJDT. This study was aimed to explore an approach that could be applied to integrate the pharmacokinetic behavior of different components derived from HLJDT. The integrated pharmacokinetic results also provided more information for further understanding of the clinical cerebrovascular disease in use of HLJDT. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  14. Bioinformatics Analysis for the Antirheumatic Effects of Huang-Lian-Jie-Du-Tang from a Network Perspective

    Directory of Open Access Journals (Sweden)

    Haiyang Fang

    2013-01-01

    Full Text Available Huang-Lian-Jie-Du-Tang (HLJDT is a classic TCM formula to clear “heat” and “poison” that exhibits antirheumatic activity. Here we investigated the therapeutic mechanisms of HLJDT at protein network level using bioinformatics approach. It was found that HLJDT shares 5 target proteins with 3 types of anti-RA drugs, and several pathways in immune system and bone formation are significantly regulated by HLJDT’s components, suggesting the therapeutic effect of HLJDT on RA. By defining an antirheumatic effect score to quantitatively measure the therapeutic effect, we found that the score of each HLJDT’s component is very low, while the whole HLJDT achieves a much higher effect score, suggesting a synergistic effect of HLJDT achieved by its multiple components acting on multiple targets. At last, topological analysis on the RA-associated PPI network was conducted to illustrate key roles of HLJDT’s target proteins on this network. Integrating our findings with TCM theory suggests that HLJDT targets on hub nodes and main pathway in the Hot ZENG network, and thus it could be applied as adjuvant treatment for Hot-ZENG-related RA. This study may facilitate our understanding of antirheumatic effect of HLJDT and it may suggest new approach for the study of TCM pharmacology.

  15. Assessment of vocal cord nodules: a case study in speech processing by using Hilbert-Huang Transform

    International Nuclear Information System (INIS)

    Civera, M; Surace, C; Filosi, C M; Silvestrini, M; Pugno, N M; Worden, K

    2017-01-01

    Vocal cord nodules represent a pathological condition for which the growth of unnatural masses on vocal folds affects the patients. Among other effects, changes in the vocal cords’ overall mass and stiffness alter their vibratory behaviour, thus changing the vocal emission generated by them. This causes dysphonia, i.e. abnormalities in the patients’ voice, which can be analysed and inspected via audio signals. However, the evaluation of voice condition through speech processing is not a trivial task, as standard methods based on the Fourier Transform, fail to fit the non-stationary nature of vocal signals. In this study, four audio tracks, provided by a volunteer patient, whose vocal fold nodules have been surgically removed, were analysed using a relatively new technique: the Hilbert-Huang Transform (HHT) via Empirical Mode Decomposition (EMD); specifically, by using the CEEMDAN (Complete Ensemble EMD with Adaptive Noise) algorithm. This method has been applied here to speech signals, which were recorded before removal surgery and during convalescence, to investigate specific trends. Possibilities offered by the HHT are exposed, but also some limitations of decomposing the signals into so-called intrinsic mode functions (IMFs) are highlighted. The results of these preliminary studies are intended to be a basis for the development of new viable alternatives to the softwares currently used for the analysis and evaluation of pathological voice. (paper)

  16. Compositions, Formation Mechanism, and Neuroprotective Effect of Compound Precipitation from the Traditional Chinese Prescription Huang-Lian-Jie-Du-Tang

    Directory of Open Access Journals (Sweden)

    Chenze Zhang

    2016-08-01

    Full Text Available Compounds in the form of precipitation (CFP are universally formed during the decocting of Chinese prescriptions, such as Huang-Lian-Jie-Du-Tang (HLJDT. The formation rate of HLJDT CFP even reached 2.63% ± 0.20%. The identification by liquid chromatography mass spectrometry (LC-MSn proved that the main chemical substances of HLJDT CFP are baicalin and berberine, which is coincident with the theory that the CFP might derive from interaction between acidic and basic compounds. To investigate the formation mechanism of HLJDT CFP, baicalin and berberine were selected to synthesize a simulated precipitation and then the baicalin–berberine complex was obtained. Results indicated that the melting point of the complex interposed between baicalin and berberine, and the UV absorption, was different from the mother material. In addition, 1H-NMR integral and high-resolution mass spectroscopy (HR-MS can validate that the binding ratio was 1:1. Compared with baicalin, the chemical shifts of H and C on glucuronide had undergone significant changes by 1H-, 13C-NMR, which proved that electron transfer occurred between the carboxylic proton and the lone pair of electrons on the N atom. Both HLJDT CFP and the baicalin–berberine complex showed protective effects against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. It is a novel idea, studying the material foundation of CFP in Chinese prescriptions.

  17. Endophytic fungal communities associated with field-grown soybean roots and seeds in the Huang-Huai region of China

    Directory of Open Access Journals (Sweden)

    Hongjun Yang

    2018-04-01

    Full Text Available Plants depend on beneficial interactions between roots and fungal endophytes for growth, disease suppression, and stress tolerance. In this study, we characterized the endophytic fungal communities associated with the roots and corresponding seeds of soybeans grown in the Huang-Huai region of China. For the roots, we identified 105 and 50 genera by culture-independent and culture-dependent (CD methods, respectively, and isolated 136 fungal strains (20 genera from the CD samples. Compared with the 52 soybean endophytic fungal genera reported in other countries, 28 of the genera we found were reported, and 90 were newly discovered. Even though Fusarium was the most abundant genus of fungal endophyte in every sample, soybean root samples from three cities exhibited diverse endophytic fungal communities, and the results between samples of roots and seeds were also significantly different. Together, we identified the major endophytic fungal genera in soybean roots and seeds, and revealed that the diversity of soybean endophytic fungal communities was influenced by geographical effects and tissues. The results will facilitate a better understanding of soybean–endophytic fungi interaction systems and will assist in the screening and utilization of beneficial microorganisms to promote healthy of plants such as soybean.

  18. Feature Extraction and Classification of EHG between Pregnancy and Labour Group Using Hilbert-Huang Transform and Extreme Learning Machine.

    Science.gov (United States)

    Chen, Lili; Hao, Yaru

    2017-01-01

    Preterm birth (PTB) is the leading cause of perinatal mortality and long-term morbidity, which results in significant health and economic problems. The early detection of PTB has great significance for its prevention. The electrohysterogram (EHG) related to uterine contraction is a noninvasive, real-time, and automatic novel technology which can be used to detect, diagnose, or predict PTB. This paper presents a method for feature extraction and classification of EHG between pregnancy and labour group, based on Hilbert-Huang transform (HHT) and extreme learning machine (ELM). For each sample, each channel was decomposed into a set of intrinsic mode functions (IMFs) using empirical mode decomposition (EMD). Then, the Hilbert transform was applied to IMF to obtain analytic function. The maximum amplitude of analytic function was extracted as feature. The identification model was constructed based on ELM. Experimental results reveal that the best classification performance of the proposed method can reach an accuracy of 88.00%, a sensitivity of 91.30%, and a specificity of 85.19%. The area under receiver operating characteristic (ROC) curve is 0.88. Finally, experimental results indicate that the method developed in this work could be effective in the classification of EHG between pregnancy and labour group.

  19. II. Comment on “Critique and correction of the currently accepted solution of the infinite spherical well in quantum mechanics” by Huang Young-Sea and Thomann Hans-Rudolph

    Science.gov (United States)

    Prados, Antonio; Plata, Carlos A.

    2016-12-01

    We comment on the paper "Critique and correction of the currently accepted solution of the infinite spherical well in quantum mechanics" by Huang Young-Sea and Thomann Hans-Rudolph, EPL 115, 60001 (2016) .

  20. M&A information technology best practices

    CERN Document Server

    Roehl-Anderson, Janice M

    2013-01-01

    Add value to your organization via the mergers & acquisitions IT function  As part of Deloitte Consulting, one of the largest mergers and acquisitions (M&A) consulting practice in the world, author Janice Roehl-Anderson reveals in M&A Information Technology Best Practices how companies can effectively and efficiently address the IT aspects of mergers, acquisitions, and divestitures. Filled with best practices for implementing and maintaining systems, this book helps financial and technology executives in every field to add value to their mergers, acquisitions, and/or divestitures via the IT

  1. MaRIE Undulator & XFEL Systems

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Dinh Cong [Los Alamos National Laboratory; Marksteiner, Quinn R. [Los Alamos National Laboratory; Anisimov, Petr Mikhaylovich [Los Alamos National Laboratory; Buechler, Cynthia Eileen [Los Alamos National Laboratory

    2015-03-23

    The 22 slides in this presentation treat the subject under the following headings: MaRIE XFEL Performance Parameters, Input Electron Beam Parameters, Undulator Design, Genesis Simulations, Risks, and Summary It is concluded that time-dependent Genesis simulations show the MaRIE XFEL can deliver the number of photons within the required bandwidth, provided a number of assumptions are met; the highest risks are associated with the electron beam driving the XFEL undulator; and risks associated with the undulator and/or distributed seeding technique may be evaluated or retired by performing early validation experiments.

  2. Evaluation overview for the Massachusetts Childhood Obesity Research Demonstration (MA-CORD) project.

    Science.gov (United States)

    Davison, Kirsten K; Falbe, Jennifer; Taveras, Elsie M; Gortmaker, Steve; Kulldorff, Martin; Perkins, Meghan; Blaine, Rachel E; Franckle, Rebecca L; Ganter, Claudia; Baidal, Jennifer Woo; Kwass, Jo-Ann; Buszkiewicz, James; Smith, Lauren; Land, Thomas

    2015-02-01

    The Massachusetts Childhood Obesity Research Demonstration (MA-CORD) project is a 2-year, multilevel, multisector community intervention to prevent and control obesity among children 2-12 years of age from two predominantly low-income communities in Massachusetts. MA-CORD includes evidence-based interventions in multiple sectors, including community health centers, early care and education centers, schools, afterschool programs, the Special Supplemental Nutrition Program for Women, Infants and Children, and the broader community. Currently, implementation of MA-CORD is complete and the final year of data collection is in progress. Here, the MA-CORD evaluation plan is described and baseline data are presented. The impact of MA-CORD on children's BMI, lifestyle behaviors, obesity-related care, and quality of life will be assessed using sector-specific, pre/post, time-series, and quasi-experimental designs. Change in the primary outcomes will be compared for intervention and comparison communities. Additionally, change in mean BMI and obesity prevalence in intervention school districts will be compared to similar districts throughout the state. At baseline in 2012, approximately 16% of preschool-aged and 25% of school-aged children were obese. Moreover, 15-40% of children consumed no vegetables on the previous day, 25-75% drank a sugar-sweetened beverage on the previous day, up to 87% had insufficient physical activity, 50-75% had a television in the room where they slept, and 50-80% obtained insufficient sleep. There is ample room for improvement in BMI and health behaviors in children in MA-CORD communities. If successful, MA-CORD may serve as a model for multilevel, multisector approaches to childhood obesity prevention and control.

  3. Climate change impacts on agriculture and soil carbon sequestration potential in the Huang-Hai Plain of China

    Energy Technology Data Exchange (ETDEWEB)

    Thomson, Allison M.; Izaurralde, R Cesar C.; Rosenberg, Norman J.; He, Xiaoxia

    2006-03-01

    The Huang-Hai Plain in northeast China has been cultivated for thousands of years and is the most productive wheat growing region in the country. Its agricultural future will be determined in large part by how global climatic changes affect regional conditions and by the actions China takes to mitigate or adapt to climate change impacts. One potential mitigation strategy is to promote soil carbon (C) sequestration, which would improve soil quality while simultaneously contributing to the mitigation of climate change. The IPCC estimates that 40 Pg of C could be sequestered in cropland soils worldwide over the next century. Here we assess the potential for soil C sequestration with conversion of a conventional till (CT) continuous wheat system to a wheat-corn double cropping system and by implementing no till (NT) management for both continuous wheat and wheat-corn systems. To assess the influence of these management changes under a changing climate, we use two climate change scenarios at two time periods in the EPIC agro-ecosystem simulation model. The applied climate change scenarios are from the HadCM3 Global Climate Model for the time periods 2015-2045 and 2070-2099. The HadCM3 model projects that both temperature and precipitation will increase throughout the next century with increases of greater than 5 °C and up to 300 mm possible by 2099. An increase in the variability of temperature is also projected and is, accordingly, applied in the simulations. The EPIC model indicates that winter wheat yields would increase on average by 0.2 Mg ha-1 in the 2030 period and by 0.8 Mg ha-1 in the 2085 period due largely to the warmer nighttime temperatures and higher precipitation projected by the HadCM3 model. Simulated yields were not significantly affected by imposed changes in crop management. Simulated soil organic C content was higher under both NT management and double cropping than under CT continuous wheat. Soil C sequestration rates for continuous wheat systems

  4. A Novel Characteristic Frequency Bands Extraction Method for Automatic Bearing Fault Diagnosis Based on Hilbert Huang Transform

    Directory of Open Access Journals (Sweden)

    Xiao Yu

    2015-11-01

    Full Text Available Because roller element bearings (REBs failures cause unexpected machinery breakdowns, their fault diagnosis has attracted considerable research attention. Established fault feature extraction methods focus on statistical characteristics of the vibration signal, which is an approach that loses sight of the continuous waveform features. Considering this weakness, this article proposes a novel feature extraction method for frequency bands, named Window Marginal Spectrum Clustering (WMSC to select salient features from the marginal spectrum of vibration signals by Hilbert–Huang Transform (HHT. In WMSC, a sliding window is used to divide an entire HHT marginal spectrum (HMS into window spectrums, following which Rand Index (RI criterion of clustering method is used to evaluate each window. The windows returning higher RI values are selected to construct characteristic frequency bands (CFBs. Next, a hybrid REBs fault diagnosis is constructed, termed by its elements, HHT-WMSC-SVM (support vector machines. The effectiveness of HHT-WMSC-SVM is validated by running series of experiments on REBs defect datasets from the Bearing Data Center of Case Western Reserve University (CWRU. The said test results evidence three major advantages of the novel method. First, the fault classification accuracy of the HHT-WMSC-SVM model is higher than that of HHT-SVM and ST-SVM, which is a method that combines statistical characteristics with SVM. Second, with Gauss white noise added to the original REBs defect dataset, the HHT-WMSC-SVM model maintains high classification accuracy, while the classification accuracy of ST-SVM and HHT-SVM models are significantly reduced. Third, fault classification accuracy by HHT-WMSC-SVM can exceed 95% under a Pmin range of 500–800 and a m range of 50–300 for REBs defect dataset, adding Gauss white noise at Signal Noise Ratio (SNR = 5. Experimental results indicate that the proposed WMSC method yields a high REBs fault

  5. Investigation of the Effects of Continuous Low-Dose Epidural Analgesia on the Autonomic Nervous System Using Hilbert Huang Transform

    Directory of Open Access Journals (Sweden)

    Wei-Ren Chuang

    2010-01-01

    Full Text Available Effects of continuous low-dose epidural bupivacaine (0.05-0.1% infusion on the Doppler velocimetry for labor analgesia have been well documented. The aim of this study was to monitor the activity of the autonomic nervous system (ANS for women in labor based on Hilbert Huang transform (HHT, which performs signal processing for nonlinear systems, such as human cardiac systems. Thirteen pregnant women were included in the experimental group for labor analgesia. They received continuous epidural bupivacaine 0.075% infusion. The normal-to-normal intervals (NN-interval were downloaded from an ECG holter. Another 20 pregnant women in non-anesthesia labor (average gestation age was 38.6 weeks were included in the comparison group. In this study, HHT was used to decompose components of ECG signals, which reflect three different frequency bands of a person's heart rate spectrum (viz. high frequency (HF, low frequency (LF and very low frequency (VLF. It was found that the change of energy in subjects without anesthesia was more active than that with continuous epidural bupivacaine 0.075% infusion. The energy values of the experimental group (i.e., labor analgesia of HF and LF of ANS activities were significantly lower (P < 0.05 than the values of the comparison group (viz. labor without analgesia, but the trend of energy ratio of LF/HF was opposite. In conclusion, the sympathetic and parasympathetic components of ANS are all suppressed by continuous low-dose epidural bupivacaine 0.075% infusion, but parasympathetic power is suppressed more than sympathetic power.

  6. Network pharmacology-based identification of key pharmacological pathways of Yin-Huang-Qing-Fei capsule acting on chronic bronchitis.

    Science.gov (United States)

    Yu, Guohua; Zhang, Yanqiong; Ren, Weiqiong; Dong, Ling; Li, Junfang; Geng, Ya; Zhang, Yi; Li, Defeng; Xu, Haiyu; Yang, Hongjun

    2017-01-01

    For decades in China, the Yin-Huang-Qing-Fei capsule (YHQFC) has been widely used in the treatment of chronic bronchitis, with good curative effects. Owing to the complexity of traditional Chinese herbal formulas, the pharmacological mechanism of YHQFC remains unclear. To address this problem, a network pharmacology-based strategy was proposed in this study. At first, the putative target profile of YHQFC was predicted using MedChem Studio, based on structural and functional similarities of all available YHQFC components to the known drugs obtained from the DrugBank database. Then, an interaction network was constructed using links between putative YHQFC targets and known therapeutic targets of chronic bronchitis. Following the calculation of four topological features (degree, betweenness, closeness, and coreness) of each node in the network, 475 major putative targets of YHQFC and their topological importance were identified. In addition, a pathway enrichment analysis based on the Kyoto Encyclopedia of Genes and Genomes pathway database indicated that the major putative targets of YHQFC are significantly associated with various pathways involved in anti-inflammation processes, immune responses, and pathological changes caused by asthma. More interestingly, eight major putative targets of YHQFC (interleukin [IL]-3, IL-4, IL-5, IL-10, IL-13, FCER1G, CCL11, and EPX) were demonstrated to be associated with the inflammatory process that occurs during the progression of asthma. Finally, a molecular docking simulation was performed and the results exhibited that 17 pairs of chemical components and candidate YHQFC targets involved in asthma pathway had strong binding efficiencies. In conclusion, this network pharmacology-based investigation revealed that YHQFC may attenuate the inflammatory reaction of chronic bronchitis by regulating its candidate targets, which may be implicated in the major pathological processes of the asthma pathway.

  7. Wearable Sensor-Based Human Activity Recognition Method with Multi-Features Extracted from Hilbert-Huang Transform.

    Science.gov (United States)

    Xu, Huile; Liu, Jinyi; Hu, Haibo; Zhang, Yi

    2016-12-02

    Wearable sensors-based human activity recognition introduces many useful applications and services in health care, rehabilitation training, elderly monitoring and many other areas of human interaction. Existing works in this field mainly focus on recognizing activities by using traditional features extracted from Fourier transform (FT) or wavelet transform (WT). However, these signal processing approaches are suitable for a linear signal but not for a nonlinear signal. In this paper, we investigate the characteristics of the Hilbert-Huang transform (HHT) for dealing with activity data with properties such as nonlinearity and non-stationarity. A multi-features extraction method based on HHT is then proposed to improve the effect of activity recognition. The extracted multi-features include instantaneous amplitude (IA) and instantaneous frequency (IF) by means of empirical mode decomposition (EMD), as well as instantaneous energy density (IE) and marginal spectrum (MS) derived from Hilbert spectral analysis. Experimental studies are performed to verify the proposed approach by using the PAMAP2 dataset from the University of California, Irvine for wearable sensors-based activity recognition. Moreover, the effect of combining multi-features vs. a single-feature are investigated and discussed in the scenario of a dependent subject. The experimental results show that multi-features combination can further improve the performance measures. Finally, we test the effect of multi-features combination in the scenario of an independent subject. Our experimental results show that we achieve four performance indexes: recall, precision, F-measure, and accuracy to 0.9337, 0.9417, 0.9353, and 0.9377 respectively, which are all better than the achievements of related works.

  8. Wearable Sensor-Based Human Activity Recognition Method with Multi-Features Extracted from Hilbert-Huang Transform

    Directory of Open Access Journals (Sweden)

    Huile Xu

    2016-12-01

    Full Text Available Wearable sensors-based human activity recognition introduces many useful applications and services in health care, rehabilitation training, elderly monitoring and many other areas of human interaction. Existing works in this field mainly focus on recognizing activities by using traditional features extracted from Fourier transform (FT or wavelet transform (WT. However, these signal processing approaches are suitable for a linear signal but not for a nonlinear signal. In this paper, we investigate the characteristics of the Hilbert-Huang transform (HHT for dealing with activity data with properties such as nonlinearity and non-stationarity. A multi-features extraction method based on HHT is then proposed to improve the effect of activity recognition. The extracted multi-features include instantaneous amplitude (IA and instantaneous frequency (IF by means of empirical mode decomposition (EMD, as well as instantaneous energy density (IE and marginal spectrum (MS derived from Hilbert spectral analysis. Experimental studies are performed to verify the proposed approach by using the PAMAP2 dataset from the University of California, Irvine for wearable sensors-based activity recognition. Moreover, the effect of combining multi-features vs. a single-feature are investigated and discussed in the scenario of a dependent subject. The experimental results show that multi-features combination can further improve the performance measures. Finally, we test the effect of multi-features combination in the scenario of an independent subject. Our experimental results show that we achieve four performance indexes: recall, precision, F-measure, and accuracy to 0.9337, 0.9417, 0.9353, and 0.9377 respectively, which are all better than the achievements of related works.

  9. Nitrate accumulation and leaching potential reduced by coupled water and nitrogen management in the Huang-Huai-Hai Plain.

    Science.gov (United States)

    Huang, Ping; Zhang, Jiabao; Zhu, Anning; Li, Xiaopeng; Ma, Donghao; Xin, Xiuli; Zhang, Congzhi; Wu, Shengjun; Garland, Gina; Pereira, Engil Isadora Pujol

    2018-01-01

    Irrigation and nitrogen (N) fertilization in excess of crop requirements are responsible for substantial nitrate accumulation in the soil profile and contamination of groundwater by nitrate leaching during intensive agricultural production. In this on-farm field trial, we compared 16 different water and N treatments on nitrate accumulation and its distribution in the soil profile (0-180cm), nitrate leaching potential, and groundwater nitrate concentration within a summer-maize (Zea mays L.) and winter-wheat (Triticum aestivum L.) rotation system in the Huang-Huai-Hai Plain over five cropping cycles (2006-2010). The results indicated that nitrate remaining in the soil profile after crop harvest and nitrate concentration of soil solutions at two depths (80cm and 180cm) declined with increasing irrigation amounts and increased greatly with increasing N application rates, especially for seasonal N application rates higher than 190kgNha -1 . During the experimental period, continuous torrential rainfall was the main cause for nitrate leaching beyond the root zone (180cm), which could pose potential risks for contamination of groundwater. Nitrate concentration of groundwater varied from 0.2 to 2.9mgL -1 , which was lower than the limit of 10mgL -1 as the maximum safe level for drinking water. In view of the balance between grain production and environmental consequences, seasonal N application rates of 190kgNha -1 and 150kgNha -1 were recommended for winter wheat and summer maize, respectively. Irrigation to the field capacity of 0-40cm and 0-60cm soil depth could be appropriate for maize and wheat, respectively. Therefore, taking grain yields, mineral N accumulation in the soil profile, nitrate leaching potential, and groundwater quality into account, coupled water and N management could provide an opportunity to promote grain production while reducing negative environmental impacts in this region. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Fabrication technology for ODS Alloy MA957

    International Nuclear Information System (INIS)

    ML Hamilton; DS Gelles; RJ Lobsinger; MM Paxton; WF Brown

    2000-01-01

    A successful fabrication schedule has been developed at Carpenter Technology Corporation for the production of MA957 fuel and blanket cladding. Difficulties with gun drilling, plug drawing and recrystallization were overcome to produce a pilot lot of tubing. This report documents the fabrication efforts of two qualified vendors and the support studies performed at WHC to develop the fabrication-schedule

  11. Salatoimikud : ma tahan uskuda / Mart Rummo

    Index Scriptorium Estoniae

    Rummo, Mart

    2008-01-01

    USA sarjale "The X-Files" põhinev teine järjefilm "Salatoimikud: Ma tahan uskuda" ("The X-Files: I Want to Believe") : režissöör Chris Carter : peaosades David Duchovny, Gillian Anderson : Ameerika Ühendriigid - Kanada 2008

  12. Annual Statistical Supplement, 2002

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2002 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  13. Annual Statistical Supplement, 2010

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2010 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  14. Annual Statistical Supplement, 2007

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2007 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  15. Annual Statistical Supplement, 2001

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2001 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  16. Annual Statistical Supplement, 2016

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2016 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  17. Annual Statistical Supplement, 2011

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2011 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  18. Annual Statistical Supplement, 2005

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2005 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  19. Annual Statistical Supplement, 2015

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2015 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  20. Annual Statistical Supplement, 2003

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2003 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  1. Annual Statistical Supplement, 2017

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2017 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  2. Annual Statistical Supplement, 2008

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2008 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  3. Annual Statistical Supplement, 2014

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2014 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  4. Annual Statistical Supplement, 2004

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2004 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  5. Annual Statistical Supplement, 2000

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2000 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  6. Annual Statistical Supplement, 2009

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2009 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  7. Annual Statistical Supplement, 2006

    Data.gov (United States)

    Social Security Administration — The Annual Statistical Supplement, 2006 includes the most comprehensive data available on the Social Security and Supplemental Security Income programs. More than...

  8. Mass and Reliability System (MaRS)

    Science.gov (United States)

    Barnes, Sarah

    2016-01-01

    The Safety and Mission Assurance (S&MA) Directorate is responsible for mitigating risk, providing system safety, and lowering risk for space programs from ground to space. The S&MA is divided into 4 divisions: The Space Exploration Division (NC), the International Space Station Division (NE), the Safety & Test Operations Division (NS), and the Quality and Flight Equipment Division (NT). The interns, myself and Arun Aruljothi, will be working with the Risk & Reliability Analysis Branch under the NC Division's. The mission of this division is to identify, characterize, diminish, and communicate risk by implementing an efficient and effective assurance model. The team utilizes Reliability and Maintainability (R&M) and Probabilistic Risk Assessment (PRA) to ensure decisions concerning risks are informed, vehicles are safe and reliable, and program/project requirements are realistic and realized. This project pertains to the Orion mission, so it is geared toward a long duration Human Space Flight Program(s). For space missions, payload is a critical concept; balancing what hardware can be replaced by components verse by Orbital Replacement Units (ORU) or subassemblies is key. For this effort a database was created that combines mass and reliability data, called Mass and Reliability System or MaRS. The U.S. International Space Station (ISS) components are used as reference parts in the MaRS database. Using ISS components as a platform is beneficial because of the historical context and the environment similarities to a space flight mission. MaRS uses a combination of systems: International Space Station PART for failure data, Vehicle Master Database (VMDB) for ORU & components, Maintenance & Analysis Data Set (MADS) for operation hours and other pertinent data, & Hardware History Retrieval System (HHRS) for unit weights. MaRS is populated using a Visual Basic Application. Once populated, the excel spreadsheet is comprised of information on ISS components including

  9. Model for Analysis of the Energy Demand (MAED) users' manual for version MAED-1

    International Nuclear Information System (INIS)

    1986-09-01

    This manual is organized in two major parts. The first part includes eight main sections describing how to use the MAED-1 computer program and the second one consists of five appendices giving some additional information about the program. Concerning the main sections of the manual, Section 1 gives a summary description and some background information about the MAED-1 model. Section 2 extends the description of the MAED-1 model in more detail. Section 3 introduces some concepts, mainly related to the computer requirements imposed by the program, that are used throughout this document. Sections 4 to 7 describe how to execute each of the various programs (or modules) of the MAED-1 package. The description for each module shows the user how to prepare the control and data cards needed to execute the module and how to interpret the printed output produced. Section 8 recapitulates about the use of MAED-1 for carrying out energy and electricity planning studies, describes the several phases normally involved in this type of study and provides the user with practical hints about the most important aspects that need to be verified at each phase while executing the various MAED modules

  10. Cinéma en France

    Directory of Open Access Journals (Sweden)

    Michel VIGOUROUX

    1992-06-01

    Full Text Available Le cinéma est l’objet de bases de données exhaustives sur les équipements et les fréquentations. Les données sur les salles permettent d’identifier le phénomène de concentration de propriété et d’exploitation. La perspective dynamique peut être observée sur 45 ans. À l’échelle régionale, on peut apprécier le dynamisme du cinéma en haute montagne alpine et la différence de réseaux sur le territoire (France de l’Ouest.

  11. Pharmacokinetic-Pharmacodynamic Analysis on Inflammation Rat Model after Oral Administration of Huang Lian Jie Du Decoction.

    Directory of Open Access Journals (Sweden)

    Wei Ren

    Full Text Available Huang-Lian-Jie-Du Decoction (HLJDD is a classical Traditional Chinese Medicine (TCM formula with heat-dissipating and detoxifying effects. It is used to treat inflammation-associated diseases. However, no systematic pharmacokinetic (PK and pharmacodynamic (PD data concerning the activity of HLJDD under inflammatory conditions is available to date. In the present study, the concentration-time profiles and the hepatic clearance rates (HCR of 41 major components in rat plasma in response to the oral administration of a clinical dose of HLJDD were investigated by LC-QqQ-MS using a dynamic multiple reaction monitoring (DMRM method. Additionally, the levels of 7 cytokines (CKs in the plasma and the body temperature of rats were analyzed. Furthermore, a PK-PD model was established to describe the time course of the hemodynamic and anti-inflammatory effects of HLJDD. As one of the three major active constituents in HLJDD, iridoids were absorbed and eliminated more easily and quickly than alkaloids and flavonoids. Compared with the normal controls, the flavonoids, alkaloids and iridoids in inflamed rats exhibited consistently changing trends of PK behaviors, such as higher bioavailability, slower elimination, delays in reaching the maximum concentration (Tmax and longer substantivity. The HCR of iridoids was different from that of alkaloids and flavonoids in inflamed rats. Furthermore, excellent pharmacodynamic effects of HLJDD were observed in inflamed rats. The levels of tumor necrosis factor-α (TNF-α, interleukin-6 (IL-6, IL-1β, IL-10, and macrophage inflammatory protein-2 (MIP-2 and body temperature significantly decreased after the administration of HLJDD. Based on PK-PD modeling with the three-phase synchronous characterization of time-concentration-effect, flavonoids exhibited one mechanism of action in the anti-inflammatory process, while iridoids and alkaloids showed another mechanism of action. Taken together, the results demonstrated that

  12. Microcap M&A: An Exploratory Study

    Directory of Open Access Journals (Sweden)

    Keith Turpie

    2014-06-01

    Full Text Available A substantial body of accounting and finance literature has been devoted to the study of Mergers and Acquisitions (M&As dominated by discussions relating to the gains and losses that accrue from transactions involving large public companies. This paper makes a unique contribution to the literature by investigating the M&A experience of microcap businesses. Transactions involving microcap M&A are substantially different to those involving large companies on a number of dimensions. This paper explores the determinants of microcap M&A success and pitfalls and problems from an integration perspective. Due to the paucity of research in the area an exploratory research design is employed, conducting interviews with five CEOs of companies that had each managed multiple transactions. We find microcap M&As are successful when measured against identified goals but generally take longer and cost more than expected. Further, culture and communication are key issues in determining success/failure. We also find the in-house management of integration aspects is problematic for these businesses and suggest this warrants further study.

  13. Milliste plaanidega lähed vastu uuele õppeaastale? / Triinu Lepp, Gleb Tšurbanov, Erik Paemurru, Steven Huang...[jt.

    Index Scriptorium Estoniae

    2008-01-01

    Küsimusele vastavad hariduskolleegiumi algkooli 3. klassi õpilane Egert, prantsuse lütseumi 12. klassi õpilane Triinu Lepp, Sillamäe kutsekooli 3. kursuse õpilane Gleb Tšurbanov, Tallinna reaalkooli 11. klassi õpilane Erik Paemurru, Toronto Crescenti keskkooli õpilane Steven Huang, kunstiakadeemia muinsuskaitse- ja restaureerimisosakonna õppejõud Jaan Tamm, Tartu Miina Härma gümnaasiumi 2. a klassi õpilane Erki Külaots, Tallinna 21. kooli 11. klassi õpilane Sander Kaur ja Tapa gümnaasiumi 7. klassi õpilane Evelin Orgse

  14. Alleviative Effects of a Kampo (a Japanese Herbal Medicine “Maoto (Ma-Huang-Tang” on the Early Phase of Influenza Virus Infection and Its Possible Mode of Action

    Directory of Open Access Journals (Sweden)

    Takayuki Nagai

    2014-01-01

    Full Text Available A Kampo medicine, maoto, has been prescribed in an early phase of influenza-like illness and used for a treatment of influenza clinically in Japan these days. However, the efficacy of maoto against the virus infection remains to be elucidated. This study was conducted to evaluate the alleviative effects of maoto against early phase of influenza virus infection and its preliminary mode of actions through immune systems. When maoto (0.9 and 1.6 g/kg/day was orally administered to A/J mice on upper respiratory tract infection of influenza virus A/PR/8/34 from 4 hours to 52 hours postinfection (p.i. significant antipyretic effect was shown in comparison with water-treated control. Administration of maoto (0.8 and 1.3 g/kg/day significantly decreased the virus titers in both nasal (NLF and bronchoalveolar lavage fluids (BALF at 52 hours p.i., and significantly increased the anti-influenza virus IgM, IgA, and IgG1 antibody titers in NLF, BALF, and serum, respectively. Maoto also increased significantly the influenza virus-bound IgG1 and IgM antibody titers in serum and the virus-bound IgM antibody titer in even the BALF of uninfected A/J mice. These results indicate that maoto exerts antipyretic activity in influenza virus-infected mice and virus reducing effect at an early phase of the infection through probably augmentation of the virus-bound natural antibodies.

  15. Functional Representation for the Born-Oppenheimer Diagonal Correction and Born-Huang Adiabatic Potential Energy Surfaces for Isotopomers of H3

    International Nuclear Information System (INIS)

    Mielke, Steven L.; Schwenke, David; Schatz, George C.; Garrett, Bruce C.; Peterson, Kirk A.

    2009-01-01

    Multireference configuration interaction (MRCI) calculations of the Born-Oppenheimer diagonal correction (BODC) for H3 were performed at 1397 symmetry-unique configurations using the Born-Huang approach; isotopic substitution leads to 4041 symmetry-unique configurations for the DH2 mass combination. These results were then fit to a functional form that permits calculation of the BODC for any combination of isotopes. Mean unsigned fitting errors on a test grid of configurations not included in the fitting process were 0.14, 0.12, and 0.65 cm-1 for the H3, DH2, and MuH2 isotopomers, respectively. This representation can be combined with any Born-Oppenheimer potential energy surface (PES) to yield Born-Huang (BH) PESs; herein we choose the CCI potential energy surface, the uncertainties of which (∼0.01 kcal/mol) are much smaller than the magnitude of the BODC. FORTRAN routines to evaluate these BH surfaces are provided. Variational transition state theory calculations are presented comparing thermal rate constants for reactions on the BO and BH surfaces to provide an initial estimate of the significance of the diagonal correction for the dynamics.

  16. Maïs beperkt nitraatverlies van gras

    NARCIS (Netherlands)

    Verloop, J.; Boumans, L.

    2006-01-01

    Maïs staat bekend als een gewas dat veel nitraat naar het grondwater lekt. Maar maïs heeft ook goeie kanten. Nieuw in dit rijtje is dat maïs, in vruchtwisseling met gras, ook het nitraatverlies van grasland beperkt. Dit blijkt uit de metingen van het RIVM op De Marke.

  17. A "embolada" em Macunaíma

    Directory of Open Access Journals (Sweden)

    Raimunda B. Batista

    2004-12-01

    Full Text Available Os intelectuais do modernismo brasileiro tiveram como preocupação a redefinição da cultura brasileira tomando como ponto de partida a cultura popular e o folclore brasileiros. Em Macunaíma, Mário de Andrade aproveita os mais variados elementos da cultura popular, dando-lhes uma configuração erudita. Entre esses elementos destacamos o aproveitamento da embolada que, enquanto modo de cantar, possui uma forte estrutura poética, podendo ser aproveitada na prosa de ficção, conservando o seu ritmo e forma.

  18. Analysis of multi-scale chaotic characteristics of wind power based on Hilbert–Huang transform and Hurst analysis

    International Nuclear Information System (INIS)

    Liang, Zhengtang; Liang, Jun; Zhang, Li; Wang, Chengfu; Yun, Zhihao; Zhang, Xu

    2015-01-01

    Highlights: • A scale division method of wind power based on HHT and Hurst analysis is proposed. • The time–frequency components of wind power show different fractal structures. • These components are superposed and reconstructed into three scale subsequences. • Each subsequence has a chaotic characteristic and shows its own properties. • The EMD-LSSVM + ELM method improves the short-term wind power forecasting accuracy. - Abstract: The causes of uncertainty in wind farm power generation are not yet fully understood. A method for the scale division of wind power based on the Hilbert–Huang transform (HHT) and Hurst analysis is proposed in this paper, which allows the various multi-scale chaotic characteristics of wind power to be investigated to reveal further information about the dynamic behavior of wind power. First, the time–frequency characteristics of wind power are analyzed using the HHT, and then Hurst analysis is applied to analyze the stochastic/persistent characteristics of the different time–frequency components. Second, based on their fractal structures, the components are superposed and reconstructed into three series, which are defined as the Micro-, Meso- and Macro-scale subsequences. Finally, indices related to the statistical and behavioral characteristics of the subsequences are calculated and used to analyze their nonlinear dynamic behavior. The data collected from a wind farm of Hebei Province, China, are selected for case studies. The simulation results reveal that (1) although the time–frequency components can be decomposed, the different fractal structures of the signal are also derived from the original series; (2) the three scale subsequences all present chaotic characteristics and each of them exhibits its own unique properties. The Micro-scale subsequence shows strong randomness and contributes the least to the overall fluctuations; the Macro-scale subsequence is the steadiest and exhibits the most significant tendency

  19. Molecular and clinical diversity in paraneoplastic immunity to Ma proteins.

    Science.gov (United States)

    Rosenfeld, M R; Eichen, J G; Wade, D F; Posner, J B; Dalmau, J

    2001-09-01

    Antibodies to Ma1 and Ma2 proteins identify a paraneoplastic disorder that affects the limbic system, brain stem, and cerebellum. Preliminary studies suggested the existence of other Ma proteins and different patterns of immune response associated with distinct neurologic symptoms and cancers. In this study, our aim was to isolate the full-length sequence of Ma2 and new family members, identify the major autoantigen of the disorder, and extend the dinical-immunological analysis to 29 patients. Sera from selected patients were used to probe a brainstem cDNA library and isolate the entire Ma2 gene and a new family member, Ma3. Ma3 mRNA is ubiquitously expressed in brain, testis, and several systemic tissues. The variable cellular expression of Ma proteins and analysis of protein motifs suggest that these proteins play roles in the biogenesis of mRNA. Immunoblot studies identify Ma2 as the major autoantigen with unique epitopes recognized by all patients' sera. Eighteen patients had antibodies limited to Ma2: they developed limbic, hypothalamic, and brainstem encephalitis, and 78% had germ-cell tumors of the testis. Eleven patients had antibodies to Ma2 and additional antibodies to Ma1 and/or Ma3; they usually developed additional cerebellar symptoms and more intense brainstem dysfunction, and 82% of these patients had tumors other than germ-cell neoplasms. Overall, 17 of 24 patients (71%) with brain magnetic resonance imaging studies had abnormalities within or outside the temporal lobes, some as contrast-enhancing nodular lesions. A remarkable finding of immunity to Ma proteins is that neurologic symptoms may improve or resolve. This improvement segregated to a group of patients with antibodies limited to Ma2.

  20. Ma Ying-jeou’s Presidential Discourse

    Directory of Open Access Journals (Sweden)

    Jonathan Sullivan

    2012-01-01

    Full Text Available Despite the substantial advances made in cross-Strait relations during Ma Ying-jeou’s (Ma Yingjiu first term, the ROC president’s rhetoric varied considerably as he grappled with the difficult reality of implementing campaign and inauguration pledges to establish better relations with China while striving to maintain national respect and sovereignty. In this article, we put forward a framework for measuring, analysing and explaining this variation in President Ma’s first-term discourse. Analysing a very large number of Ma’s speeches, addresses, etc., we provide empirical assessments of how the content of Ma’s public pronouncements has developed over time, how his rhetoric varies according to the strategic context and timing of a speech, and how his discourse compares to that of his predecessor, Chen Shui-bian (Chen Shuibian. In addressing these questions, the article contributes a quantitative perspective to existing work on political discourse in Taiwan and to the growing methodological and applied literature on how to systematically analyse Chinese political text.

  1. Kidney toxicity related to herbs and dietary supplements: Online table of case reports. Part 3 of 5 series.

    Science.gov (United States)

    Brown, Amy Christine

    2017-09-01

    herba-alba). No longer sold in the United States are chocolate vine or mu tong (Caulis aristolochiae), guang fang ji (Aristolochia fangchi), ma huang (Ephedra sinica), and Tenshin Tokishigyaku-ka-goshuyu-shokyo-to. The DS include bile (sheep), chlorella, chromium (Cr), CKLS, creatine, gallbladder (fish), glucosamine, hydrazine, N.O.-Xplode, Spanish fly, and excess intakes of vitamins A, C, and D. Germanium (Ge) is not available for sale. The top two DS with the largest number of reported publications, but not always case reports, in descending order, were the aristolochic acid-containing herbs guang fang ji (mistaken identity) and chocolate vine or mu tong. The remaining DS featured one to three publications over a 50+ year period. Numerous case reports were reported for kidney-toxic foods: djenkol bean, gallbladders (carp fish, pufferfish, & snake), and star fruit (only in chronic kidney disease patients), and uncooked yam powder or juice. This online "DS Toxic Table" provides clinicians, consumers, and manufacturers with a list of herbs that could potentially contribute to kidney injuries. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Children and Dietary Supplements

    Science.gov (United States)

    ... Clinical Digest for health professionals Children and Dietary Supplements Share: September 2012 © Matthew Lester Research has shown that many children use herbs and other dietary supplements. However, there are little data available on their ...

  3. Taking iron supplements

    Science.gov (United States)

    ... medlineplus.gov/ency/article/007478.htm Taking iron supplements To use the sharing features on this page, ... levels. You may also need to take iron supplements as well to rebuild iron stores in your ...

  4. Identification and characterization of novel NuMA isoforms

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Jin, E-mail: petersdu2112@hotmail.com [Key Laboratory for Cell Proliferation and Regulation of the Ministry of Education, Beijing Normal University, Beijing (China); Xu, Zhe [Department of Clinical Laboratory Diagnosis, Beijing Tiantan Hospital, Capital Medical University, Beijing (China); Core Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing (China); He, Dacheng [Key Laboratory for Cell Proliferation and Regulation of the Ministry of Education, Beijing Normal University, Beijing (China); Lu, Guanting, E-mail: guantlv@126.com [Beijing DnaLead Science and Technology Co., LTD, Beijing (China)

    2014-11-21

    Highlights: • Seven NuMA isoforms generated by alternative splicing were categorized into 3 groups: long, middle and short. • Both exons 15 and 16 in long NuMA were “hotspot” for alternative splicing. • Lower expression of short NuMA was observed in cancer cells compared with nonneoplastic controls. • Distinct localization pattern of short isoforms indicated different function from that of long and middle NuMA. - Abstract: The large nuclear mitotic apparatus (NuMA) has been investigated for over 30 years with functions related to the formation and maintenance of mitotic spindle poles during mitosis. However, the existence and functions of NuMA isoforms generated by alternative splicing remains unclear. In the present work, we show that at least seven NuMA isoforms (categorized into long, middle and short groups) generated by alternative splicing from a common NuMA mRNA precursor were discovered in HeLa cells and these isoforms differ mainly at the carboxyl terminus and the coiled-coil domains. Two “hotspot” exons with molecular mass of 3366-nt and 42-nt tend to be spliced during alternative splicing in long and middle groups. Furthermore, full-length coding sequences of long and middle NuMA obtained by using fusion PCR were constructed into GFP-tagged vector to illustrate their cellular localization. Long NuMA mainly localized in the nucleus with absence from nucleoli during interphase and translocated to the spindle poles in mitosis. Middle NuMA displayed the similar cell cycle-dependent distribution pattern as long NuMA. However, expression of NuMA short isoforms revealed a distinct subcellular localization. Short NuMA were present in the cytosol during the whole cycle, without colocalization with mitotic apparatus. These results have allowed us tentatively to explore a new research direction for NuMA’s various functions.

  5. Volcanism at 1.45 Ma within the Yellowstone Volcanic Field, United States

    Science.gov (United States)

    Rivera, Tiffany A.; Furlong, Ryan; Vincent, Jaime; Gardiner, Stephanie; Jicha, Brian R.; Schmitz, Mark D.; Lippert, Peter C.

    2018-05-01

    Rhyolitic volcanism in the Yellowstone Volcanic Field has spanned over two million years and consisted of both explosive caldera-forming eruptions and smaller effusive flows and domes. Effusive eruptions have been documented preceding and following caldera-forming eruptions, however the temporal and petrogenetic relationships of these magmas to the caldera-forming eruptions are relatively unknown. Here we present new 40Ar/39Ar dates for four small-volume eruptions located on the western rim of the second-cycle caldera, the source of the 1.300 ± 0.001 Ma Mesa Falls Tuff. We supplement our new eruption ages with whole rock major and trace element chemistry, Pb isotopic ratios of feldspar, and paleomagnetic and rock magnetic analyses. Eruption ages for the effusive Green Canyon Flow (1.299 ± 0.002 Ma) and Moonshine Mountain Dome (1.302 ± 0.003 Ma) are in close temporal proximity to the eruption age of the Mesa Falls Tuff. In contrast, our results indicate a period of volcanism at ca 1.45 Ma within the Yellowstone Volcanic Field, including the eruption of the Bishop Mountain Flow (1.458 ± 0.002 Ma) and Tuff of Lyle Spring (1.450 ± 0.003 Ma). These high-silica rhyolites are chemically and isotopically distinct from the Mesa Falls Tuff and related 1.3 Ma effusive eruptions. The 40Ar/39Ar data from the Tuff of Lyle Spring demonstrate significant antecrystic inheritance, prevalent within the upper welded ash-flow tuff matrix, and minimal within individual pumice. Antecrysts are up to 20 kyr older than the eruption, with subpopulations of grains occurring every few thousand years. We interpret these results as an indicator for the timing of magmatic pulses into a growing magmatic system that would ultimately erupt the Tuff of Lyle Spring, and which we more broadly interpret as the tempo of crustal accumulation associated with bimodal magmatism. We propose a system whereby chemically, isotopically, and temporally distinct, isolated small-volume magma batches are

  6. Change management in bank M&A

    Directory of Open Access Journals (Sweden)

    Kontić Ljiljana

    2014-01-01

    Full Text Available This paper examines the issues of change management in merger and acquisitions (M&As using the mixed method research approach. The research setting consisted of a foreign bank that operates in Serbia. The main aim of this study is to examine willingness for change in bank M&A. The qualitative data about the bank were sourced from publicly available information about the bank. The standardized questionnaire is used to assess bank's willingness for change. Based on managers structure, the representative sample of middle managers has been interviewed in this study. The research findings revealed possible practical implementation of the questionnaire in the Serbian banking sector. The results revealed that changes in bank should be led top down. The findings add to the existing literature on success factors in cross-border mergers and acquisitions. The study limitation are suggested.

  7. Impact of climate change on potential evapotranspiration under a historical and future climate scenario in the Huang-Huai-Hai Plain, China

    Science.gov (United States)

    Liu, Qin; Yan, Changrong; Ju, Hui; Garré, Sarah

    2018-04-01

    Climate change is widely accepted to be one of the most critical problems faced by the Huang-Huai-Hai Plain (3H Plain), which is a region in which there is an over-exploitation of groundwater and where future warmer and drought conditions might intensify crop water demand. In this study, the spatiotemporal patterns of ET0 and primary driving meteorological variables were investigated based on a historical and RCP 8.5 scenario daily data set from 40 weather stations over the 3H Plain using linear regression, spline interpolation method, a partial derivative analysis, and multivariate regression. The results indicated a negative trend in all the analysed periods (except spring) of the past 54 years of which only summer and the entire year were statistically significant ( p use of water resources and a sustainable agricultural production in the 3H Plain.

  8. On-site ocean horizontal aerosol extinction coefficient inversion under different weather conditions on the Bo-hai and Huang-hai Seas

    Science.gov (United States)

    Zeng, Xianjiang; Xia, Min; Ge, Yinghui; Guo, Wenping; Yang, Kecheng

    2018-03-01

    In this paper, we explore the horizontal extinction characteristics under different weather conditions on the ocean surface with on-site experiments on the Bo-hai and Huang-hai Seas in the summer of 2016. An experimental lidar system is designed to collect the on-site experimental data. By aiming at the inhomogeneity and uncertainty of the horizontal aerosol in practice, a joint retrieval method is proposed to retrieve the aerosol extinction coefficients (AEC) from the raw data along the optical path. The retrieval results of both the simulated and the real signals demonstrate that the joint retrieval method is practical. Finally, the sequence observation results of the on-site experiments under different weather conditions are reported and analyzed. These results can provide the attenuation information to analyze the atmospheric aerosol characteristics on the ocean surface.

  9. Hilbert-Huang Spectrum as a new field for the identification of EEG event related de-/synchronization for BCI applications.

    Science.gov (United States)

    Panoulas, Konstantinos I; Hadjileontiadis, Leontios J; Panas, Stavros M

    2008-01-01

    Brain Computer Interfaces (BCI) usually utilize the suppression of mu-rhythm during actual or imagined motor activity. In order to create a BCI system, a signal processing method is required to extract features upon which the discrimination is based. In this article, the Empirical Mode Decomposition along with the Hilbert-Huang Spectrum (HHS) is found to contain the necessary information to be considered as an input to a discriminator. Also, since the HHS defines amplitude and instantaneous frequency for each sample, it can be used for an online BCI system. Experimental results when the HHS applied to EEG signals from an on-line database (BCI Competition III) show the potentiality of the proposed analysis to capture the imagined motor activity, contributing to a more enhanced BCI performance.

  10. Two-shot fringe pattern phase-amplitude demodulation using Gram-Schmidt orthonormalization with Hilbert-Huang pre-filtering.

    Science.gov (United States)

    Trusiak, Maciej; Patorski, Krzysztof

    2015-02-23

    Gram-Schmidt orthonormalization is a very fast and efficient method for the fringe pattern phase demodulation. It requires only two arbitrarily phase-shifted frames. Images are treated as vectors and upon orthogonal projection of one fringe vector onto another the quadrature fringe pattern pair is obtained. Orthonormalization process is very susceptible, however, to noise, uneven background and amplitude modulation fluctuations. The Hilbert-Huang transform based preprocessing is proposed to enhance fringe pattern phase demodulation by filtering out the spurious noise and background illumination and performing fringe normalization. The Gram-Schmidt orthonormalization process error analysis is provided and its filtering-expanded capabilities are corroborated analyzing DSPI fringes and performing amplitude demodulation of Bessel fringes. Synthetic and experimental fringe pattern analyses presented to validate the proposed technique show that it compares favorably with other pre-filtering schemes, i.e., Gaussian filtering and continuous wavelet transform.

  11. Automated flaw detection scheme for cast austenitic stainless steel weld specimens using Hilbert-Huang transform of ultrasonic phased array data

    International Nuclear Information System (INIS)

    Khan, Tariq; Majumdar, Shantanu; Udpa, Lalita; Ramuhalli, Pradeep; Crawford, Susan; Diaz, Aaron; Anderson, Michael T.

    2012-01-01

    The objective of this work is to develop processing algorithms to detect and localize flaws using ultrasonic phased-array data. Data was collected on cast austenitic stainless stell (CASS) weld specimens onloan from the U.S. nuclear power industry' Pressurized Walter Reactor Owners Group (PWROG) traveling specimen set. Each specimen consists of a centrifugally cast stainless stell (CCSS) pipe section welded to a statically cst(SCSS) or wrought (WRSS) section. The paper presents a novel automated flaw detection and localization scheme using low frequency ultrasonic phased array inspection singals from the weld and heat affected zone of the based materials. The major steps of the overall scheme are preprocessing and region of interest (ROI) detection followed by the Hilbert-Huang transform (HHT) of A-scans in the detected ROIs. HHT offers time-frequency-energy distribution for each ROI. The Accumulation of energy in a particular frequency band is used as a classification feature for the particular ROI

  12. Compter mes jours : recherche explorant l'espace entre ma pratique artistique et ma pratique comptable

    OpenAIRE

    Picard, Julie

    2017-01-01

    Cette recherche propose d’investiguer l’espace entre ma pratique artistique et ma pratique comptable à travers une approche qui déploie des activités de recherches théoriques sur l’art, des activités de recherches théoriques en comptabilité, la réalisation d’un protocole de création en atelier, et la prestation d’une conférence. L’approche flexible, multifocale et exploratoire adoptée se situe en affinité avec Intermedia, développé par Dick Higgins. Partant de ces deux figures type d’oppositi...

  13. Changing the S and MA [Safety and Mission Assurance] Paradigm

    Science.gov (United States)

    Malone, Roy W., Jr.

    2010-01-01

    Objectives: 1) Optimize S&MA organization to best facilitate Shuttle transition in 2010, successfully support Ares developmental responsibilities, and minimize the impacts of the gap between last Shuttle flight and start of Ares V Project. 2) Improve leveraging of critical skills and experience between Shuttle and Ares. 3) Split technical and supervisory functions to facilitate technical penetration. 4) Create Chief Safety and Mission Assurance Officer (CSO) stand-alone position for successfully implementation of S&MA Technical Authority. 5) Minimize disruption to customers. 6) Provide early involvement of S&MA leadership team and frequent/open communications with S&MA team members and steak-holders.

  14. O azarado Macunaíma

    Directory of Open Access Journals (Sweden)

    Priscila Figueiredo

    Full Text Available Resumo Qual o sentido dos infortúnios sucessivos de Macunaíma, sobretudo nos capítulos finais, quando, de posse do amuleto da sorte, nem por isso esta lhe sobrevém, mas ao contrário segue-se um processo cada vez mais acelerado de degradação entrópica? Umas das finalidades do artigo é mostrar, por um lado, o caiporismo do personagem como repetição estrutural, desenvolvido no âmbito da "morfologia da história" captada pelo livro, e, por outro, como esse azar permanente funciona como significante mítico de um permanente desamparo. Nesse sentido, o personagem é compreendido como uma síntese das experiências do vasto setor da população brasileira que Caio Prado Jr. chamou de inorgânico. Tal interpretação tem consequências para pensar a inadvertida mimese do real operada pela obra e a relação com a noção de progresso aí sugerida.

  15. MaROS: Information Management Service

    Science.gov (United States)

    Allard, Daniel A.; Gladden, Roy E.; Wright, Jesse J.; Hy, Franklin H.; Rabideau, Gregg R.; Wallick, Michael N.

    2011-01-01

    This software is provided by the Mars Relay Operations Service (MaROS) task to a variety of Mars projects for the purpose of coordinating communications sessions between landed spacecraft assets and orbiting spacecraft assets at Mars. The Information Management Service centralizes a set of functions previously distributed across multiple spacecraft operations teams, and as such, greatly improves visibility into the end-to-end strategic coordination process. Most of the process revolves around the scheduling of communications sessions between the spacecraft during periods of time when a landed asset on Mars is geometrically visible by an orbiting spacecraft. These relay sessions are used to transfer data both to and from the landed asset via the orbiting asset on behalf of Earth-based spacecraft operators. This software component is an application process running as a Java virtual machine. The component provides all service interfaces via a Representational State Transfer (REST) protocol over https to external clients. There are two general interaction modes with the service: upload and download of data. For data upload, the service must execute logic specific to the upload data type and trigger any applicable calculations including pass delivery latencies and overflight conflicts. For data download, the software must retrieve and correlate requested information and deliver to the requesting client. The provision of this service enables several key advancements over legacy processes and systems. For one, this service represents the first time that end-to-end relay information is correlated into a single shared repository. The software also provides the first multimission latency calculator; previous latency calculations had been performed on a mission-by-mission basis.

  16. "Sel kevadel olen ma eriti ilus..." : [luuletused] / Triin Soomets

    Index Scriptorium Estoniae

    Soomets, Triin

    2003-01-01

    Sisu: "Sel kevadel olen ma eriti ilus..." ; "Tahaksin teha midagi tõelist; midagi suurt..." ; "veebruaris on keha nii valge et syda läheb pahaks..." ; "kõige kohutavamad lepingud..." ; "Igal loojangul kutsun sind ja igal koidikul tõukan su ära..." ; "need hakid..." ; "Põhja vajudes on viimane asi, mida ma näen, rohelised sähvatused..."

  17. Alumni careers : MA Comparative European Social Studies Zuyd University

    NARCIS (Netherlands)

    Albert Riga

    2004-01-01

    In the preparation of the celebration of the 10th anniversary of the MA CESS all alumni were invited to participate in an alumni survey. The purpose of the survey was to thoroughly investigate the professional activities of MA CESS alumni and the way they build an alumni community. Another reason

  18. How to use MAED with other IAEA models in ENPEP

    International Nuclear Information System (INIS)

    Maksijan, B.

    1997-01-01

    This paper provides an outlook of the energy situation in Croatia and describes the experience with the IAEA planning methodologies with focus on the MAED model. Furthermore, it suggests an approach to integrate the results of the MAED module of ENPEP with other modules (e.g. BALANCE) by means of commercial software (EXCEL Microsoft). (author). 2 figs, 3 tabs

  19. Large area imaging of forensic evidence with MA-XRF

    NARCIS (Netherlands)

    Langstraat, K.; Knijnenberg, A.; Edelman, G.; van de Merwe, L.; van Loon, A.; Dik, J.; van Asten, A.

    2017-01-01

    This study introduces the use of macroscopic X-ray fluorescence (MA-XRF) for the detection, classification and imaging of forensic traces over large object areas such as entire pieces of clothing and wall paneling. MA-XRF was sufficiently sensitive and selective to detect human biological traces

  20. Large area imaging of forensic evidence with MA-XRF

    NARCIS (Netherlands)

    Langstraat, Kirsten; Knijnenberg, Alwin; Edelman, Gerda; Van De Merwe, Linda; van Loon, A.; Dik, J.; van Asten, Arian C.

    2017-01-01

    This study introduces the use of macroscopic X-ray fluorescence (MA-XRF) for the detection, classification and imaging of forensic traces over large object areas such as entire pieces of clothing and wall paneling. MA-XRF was sufficiently sensitive and selective to detect human biological traces

  1. 42 CFR 422.2268 - Standards for MA organization marketing.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Standards for MA organization marketing. 422.2268 Section 422.2268 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Medicare Advantage Marketing Requirements § 422.2268 Standards for MA organizatio...

  2. 42 CFR 422.4 - Types of MA plans.

    Science.gov (United States)

    2010-10-01

    ... availability, service area, and quality. (ii) Coordinated care plans may include mechanisms to control... requirements of sections 138 and 220 of the Internal Revenue Code. (3) MA private fee-for-service plan. An MA... Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

  3. How to use MAED with other IAEA models in ENPEP

    Energy Technology Data Exchange (ETDEWEB)

    Maksijan, B [Energy Sector, Ministry of Economic Affairs, Zagreb (Croatia)

    1997-09-01

    This paper provides an outlook of the energy situation in Croatia and describes the experience with the IAEA planning methodologies with focus on the MAED model. Furthermore, it suggests an approach to integrate the results of the MAED module of ENPEP with other modules (e.g. BALANCE) by means of commercial software (EXCEL Microsoft). (author). 2 figs, 3 tabs.

  4. The (mis)Measurement of M&A Performance

    DEFF Research Database (Denmark)

    Meglio, Olimpia; Risberg, Annette

    2011-01-01

    This paper seeks to further the understanding of the variety of meanings M&A scholars attach to the label “M&A performance” by providing an alternative way to interpret the claimed inconsistency of M&A research findings. While many scholars contend that the problem stems from the multiplicity of M......&A performance measures, we believe the problem rests in trying to compare different measures as if they were measuring the same feature of the organization. Through our narrative review of empirical research we analyze factors shaping the M&A – as well as the organizational – performance measurement process....... The conclusion is that it is not possible to talk about M&A performance as if it was a universal construct....

  5. Resveratrol food supplements

    DEFF Research Database (Denmark)

    Aschemann-Witzel, Jessica; Grunert, Klaus G

    2015-01-01

    Background: Consumers increasingly choose food supplements in addition to their diet. Research on supplement users finds they are likely to be female, older and well-educated; Furthermore, supplement users are often characterised as being especially health-oriented, an observation which is termed...... the ‘inverse supplement hypothesis’. However, results are dependent on the substance in question. Little is known so far about botanicals in general, and more specifically, little is known about resveratrol. The psychographic variables of food supplement users are yet relatively underexplored. By comparing US...... and Danish respondents, we aimed to identify whether sociodemographic variables, health status, health beliefs and behaviour and interest in food aspects specifically relevant to resveratrol (e.g., naturalness, indulgence, and Mediterranean food) explain favourable attitudes and adoption intentions toward...

  6. Ma ma (2015. A reflection of the Spanish woman with breast cáncer

    Directory of Open Access Journals (Sweden)

    Clara PERALTA NUENO

    2017-12-01

    Full Text Available Ma ma (2015 is a Spanish drama film directed by Julio Medem and produced by Morena Films. This film tells the story of Magda’s life, whose character is interpreted by Penélope Cruz. After being diagnosed with a breast cancer, Magda, an unemployed teacher, will not know how to act nor how this disease will change her life. But little by little, she will bring into the surface all her vital energy. Breast cancer represents the most frequent type of cancer among women. Although the majority of the identified risk factors can be modified, the health systems focus on activities that let strengthen the primary prevention and activities of secondary and tertiary prevention. The early detection and the right treatment are essential to fight against this disease. The emotional process caused by the presence of cancer involves a mechanism of psychic reconstitution that allows the patient develop an answer to the organic, cognitive, social, and emotional challenges they have to deal with. This process is easier when they have a solid socio-family support network among other factors.

  7. Morotochoerus from Uganda (17.5 Ma and Kenyapotamus from Kenya (13-11 Ma: implications for hippopotamid origins

    Directory of Open Access Journals (Sweden)

    Pickford, M.

    2011-12-01

    Full Text Available The aim of this paper is to describe and interpret suiform teeth from Moroto, Uganda, and Ngorora, Kenya, which contribute to the debate about hippo-anthracothere-whale relationships. The early stages of hippopotamid evolution are relatively poorly known on account of the paucity of their fossil record older than 7 Ma. New specimens of Morotochoerus from Uganda reveal that it is not closely related to Hippopotamidae; the superficial resemblances of the cheek teeth to those of hippos represent convergences and not homologies. Restricted samples of Palaeopotamus ternani are available from the Middle Miocene of Kenya {Maboko, ca 16 Ma; Muruyur, ca 14.5 Ma; Fort Ternan, ca 13.7 Ma} while from the base of the late Miocene, Kenyapotamus coryndonae is known from Kenya {Ngerngerwa, ca 10.5-10 Ma; Nakali, ca 10.5 Ma; Samburu Hills, ca 9.5 Ma}, Ethiopia {Ch’orora, ca 10.5 Ma} and Tunisia {Beglia Formation ca 11-10 Ma}. The recovery of specimens of Kenyapotamus from the Ngorora Formation, Kenya, aged ca 11 Ma, is of interest because it includes well preserved teeth, including an m/3 in good condition. These specimens support the hypothesis that hippopotamids descended from palaeochoerids and not from anthracotheres.El objetivo de este trabajo es describir e interpretar los dientes suiformes de Moroto, Uganda, y Ngorora, Kenia, que contribuyen al debate sobre las relaciones hipo-anthracothere-whale. Las primeras etapas de la evolución de los hipopotámidos son relativamente poco conocidas a causa de la escasez de su registro fósil en edades superiors a los 7 Ma. Nuevos ejemplares de Morotochoerus en Uganda revelan que no están estrechamente relacionados con Hippopotamidae, las semejanzas superficiales de los dientes de la mandíbula con los de los hipopótamos representan convergencias y no homologías. Algunas muestras de Palaeopotamus ternani aparecen en el Medio Mioceno de Kenia {Maboko, ca 16 Ma; Muruyur, ca 14.5 Ma; Fort Ternan, ca 13.7 Ma

  8. Herbs, Supplements and Alternative Medicines

    Science.gov (United States)

    ... A A Listen En Español Herbs, Supplements and Alternative Medicines It is best to get vitamins and minerals ... this section Medication Other Treatments Herbs, Supplements, and Alternative Medicines Types of Dietary Supplements Side Effects and Drug ...

  9. Model for Analysis of Energy Demand (MAED-2). User's manual

    International Nuclear Information System (INIS)

    2007-01-01

    The IAEA has been supporting its Member States in the area of energy planning for sustainable development. Development and dissemination of appropriate methodologies and their computer codes are important parts of this support. This manual has been produced to facilitate the use of the MAED model: Model for Analysis of Energy Demand. The methodology of the MAED model was originally developed by. B. Chateau and B. Lapillonne of the Institute Economique et Juridique de l'Energie (IEJE) of the University of Grenoble, France, and was presented as the MEDEE model. Since then the MEDEE model has been developed and adopted to be appropriate for modelling of various energy demand system. The IAEA adopted MEDEE-2 model and incorporated important modifications to make it more suitable for application in the developing countries, and it was named as the MAED model. The first version of the MAED model was designed for the DOS based system, which was later on converted for the Windows system. This manual presents the latest version of the MAED model. The most prominent feature of this version is its flexibility for representing structure of energy consumption. The model now allows country-specific representations of energy consumption patterns using the MAED methodology. The user can now disaggregate energy consumption according to the needs and/or data availability in her/his country. As such, MAED has now become a powerful tool for modelling widely diverse energy consumption patterns. This manual presents the model in details and provides guidelines for its application

  10. Model for Analysis of Energy Demand (MAED-2)

    International Nuclear Information System (INIS)

    2007-01-01

    The IAEA has been supporting its Member States in the area of energy planning for sustainable development. Development and dissemination of appropriate methodologies and their computer codes are important parts of this support. This manual has been produced to facilitate the use of the MAED model: Model for Analysis of Energy Demand. The methodology of the MAED model was originally developed by. B. Chateau and B. Lapillonne of the Institute Economique et Juridique de l'Energie (IEJE) of the University of Grenoble, France, and was presented as the MEDEE model. Since then the MEDEE model has been developed and adopted to be appropriate for modelling of various energy demand system. The IAEA adopted MEDEE-2 model and incorporated important modifications to make it more suitable for application in the developing countries, and it was named as the MAED model. The first version of the MAED model was designed for the DOS based system, which was later on converted for the Windows system. This manual presents the latest version of the MAED model. The most prominent feature of this version is its flexibility for representing structure of energy consumption. The model now allows country-specific representations of energy consumption patterns using the MAED methodology. The user can now disaggregate energy consumption according to the needs and/or data availability in her/his country. As such, MAED has now become a powerful tool for modelling widely diverse energy consumption patterns. This manual presents the model in details and provides guidelines for its application

  11. Model for Analysis of Energy Demand (MAED-2). User's manual

    International Nuclear Information System (INIS)

    2006-01-01

    The IAEA has been supporting its Member States in the area of energy planning for sustainable development. Development and dissemination of appropriate methodologies and their computer codes are important parts of this support. This manual has been produced to facilitate the use of the MAED model: Model for Analysis of Energy Demand. The methodology of the MAED model was originally developed by. B. Chateau and B. Lapillonne of the Institute Economique et Juridique de l'Energie (IEJE) of the University of Grenoble, France, and was presented as the MEDEE model. Since then the MEDEE model has been developed and adopted to be appropriate for modelling of various energy demand system. The IAEA adopted MEDEE-2 model and incorporated important modifications to make it more suitable for application in the developing countries, and it was named as the MAED model. The first version of the MAED model was designed for the DOS based system, which was later on converted for the Windows system. This manual presents the latest version of the MAED model. The most prominent feature of this version is its flexibility for representing structure of energy consumption. The model now allows country-specific representations of energy consumption patterns using the MAED methodology. The user can now disaggregate energy consumption according to the needs and/or data availability in her/his country. As such, MAED has now become a powerful tool for modelling widely diverse energy consumption patterns. This manual presents the model in details and provides guidelines for its application

  12. Alumni careers : MA Comparative European Social Studies Zuyd University

    OpenAIRE

    Riga, Albert

    2004-01-01

    In the preparation of the celebration of the 10th anniversary of the MA CESS all alumni were invited to participate in an alumni survey. The purpose of the survey was to thoroughly investigate the professional activities of MA CESS alumni and the way they build an alumni community. Another reason for starting the project is that it may play a part in maintaining and enhancing a mutually beneficial relationship between MA CESS and its alumni. All over Europe there are graduates working in the ...

  13. Dietary supplements for football.

    Science.gov (United States)

    Hespel, P; Maughan, R J; Greenhaff, P L

    2006-07-01

    Physical training and competition in football markedly increase the need for macro- and micronutrient intake. This requirement can generally be met by dietary management without the need for dietary supplements. In fact, the efficacy of most supplements available on the market is unproven. In addition, players must be cautious of inadequate product labelling and supplement impurities that may cause a positive drug test. Nonetheless, a number of dietary supplements may beneficially affect football performance. A high endurance capacity is a prerequisite for optimal match performance, particularly if extra time is played. In this context, the potential of low-dose caffeine ingestion (2 - 5 mg . kg body mass(-1)) to enhance endurance performance is well established. However, in the case of football, care must be taken not to overdose because visual information processing might be impaired. Scoring and preventing goals as a rule requires production of high power output. Dietary creatine supplementation (loading dose: 15 - 20 g . day(-1), 4 - 5 days; maintenance dose: 2 - 5 g g . day(-1)) has been found to increase muscle power output, especially during intermittent sprint exercises. Furthermore, creatine intake can augment muscle adaptations to resistance training. Team success and performance also depend on player availability, and thus injury prevention and health maintenance. Glucosamine or chondroitin may be useful in the treatment of joint pain and osteoarthritis, but there is no evidence to support the view that the administration of these supplements will be preventative. Ephedra-containing weight-loss cocktails should certainly be avoided due to reported adverse health effects and positive doping outcomes. Finally, the efficacy of antioxidant or vitamin C intake in excess of the normal recommended dietary dose is equivocal. Responses to dietary supplements can vary substantially between individuals, and therefore the ingestion of any supplement must be assessed

  14. Non-scientific classification of Chinese herbal medicine as dietary supplement.

    Science.gov (United States)

    Bao, Kexin

    2017-03-01

    This article focuses the category status of Chinese herbal medicine in the United States where it has been mistakenly classifified as a dietary supplement. According to Yellow Emperor Canon of Internal Medicine (Huang Di Nei Jing), clinical treatment in broad sense is to apply certain poisonous medicines to fight against pathogeneses, by which all medicines have certain toxicity and side effect. From ancient times to modern society, all, or at least most, practitioners have used herbal medicine to treat patients' medical conditions. The educational curriculums in Chinese medicine (CM) comprise the courses of herbal medicine (herbology) and herbal formulae. The objective of these courses is to teach students to use herbal medicine or formulae to treat disease as materia medica. In contrast, dietary supplements are preparations intended to provide nutrients that are missing or are not consumed in suffificient quantity in a person's diet. In contrast, Chinese herbs can be toxic, which have been proven through laboratory research. Both clinical practice and research have demonstrated that Chinese herbal medicine is a special type of natural materia medica, not a dietary supplement.

  15. Analysis and Recognition of Traditional Chinese Medicine Pulse Based on the Hilbert-Huang Transform and Random Forest in Patients with Coronary Heart Disease

    Directory of Open Access Journals (Sweden)

    Rui Guo

    2015-01-01

    Full Text Available Objective. This research provides objective and quantitative parameters of the traditional Chinese medicine (TCM pulse conditions for distinguishing between patients with the coronary heart disease (CHD and normal people by using the proposed classification approach based on Hilbert-Huang transform (HHT and random forest. Methods. The energy and the sample entropy features were extracted by applying the HHT to TCM pulse by treating these pulse signals as time series. By using the random forest classifier, the extracted two types of features and their combination were, respectively, used as input data to establish classification model. Results. Statistical results showed that there were significant differences in the pulse energy and sample entropy between the CHD group and the normal group. Moreover, the energy features, sample entropy features, and their combination were inputted as pulse feature vectors; the corresponding average recognition rates were 84%, 76.35%, and 90.21%, respectively. Conclusion. The proposed approach could be appropriately used to analyze pulses of patients with CHD, which can lay a foundation for research on objective and quantitative criteria on disease diagnosis or Zheng differentiation.

  16. Analysis and Recognition of Traditional Chinese Medicine Pulse Based on the Hilbert-Huang Transform and Random Forest in Patients with Coronary Heart Disease

    Science.gov (United States)

    Wang, Yiqin; Yan, Hanxia; Yan, Jianjun; Yuan, Fengyin; Xu, Zhaoxia; Liu, Guoping; Xu, Wenjie

    2015-01-01

    Objective. This research provides objective and quantitative parameters of the traditional Chinese medicine (TCM) pulse conditions for distinguishing between patients with the coronary heart disease (CHD) and normal people by using the proposed classification approach based on Hilbert-Huang transform (HHT) and random forest. Methods. The energy and the sample entropy features were extracted by applying the HHT to TCM pulse by treating these pulse signals as time series. By using the random forest classifier, the extracted two types of features and their combination were, respectively, used as input data to establish classification model. Results. Statistical results showed that there were significant differences in the pulse energy and sample entropy between the CHD group and the normal group. Moreover, the energy features, sample entropy features, and their combination were inputted as pulse feature vectors; the corresponding average recognition rates were 84%, 76.35%, and 90.21%, respectively. Conclusion. The proposed approach could be appropriately used to analyze pulses of patients with CHD, which can lay a foundation for research on objective and quantitative criteria on disease diagnosis or Zheng differentiation. PMID:26180536

  17. Huang Guobin’s Poetry, Literary Criticism and Translation%黄国彬的诗文创作、评论和翻译

    Institute of Scientific and Technical Information of China (English)

    黄维樑[香港

    2016-01-01

    Huang Guobin, also known as Laurence K. P. Wong, is a Hong Kong writer. He has, to date, published 15 collections of poems, seven collections of essays, and 11 monographs in literary criticism and translation studies, as well as translations of two literary works, The Divine Comedy(translated from the original Italian)and Hamlet, both of them fully annotated. All in all, even though his emphases may vary, he has brought under his jurisdiction the various types of writing d escribed in Western literary theory(poetry, prose, narrative, and so on)and the styles mentioned in the chapter“Ti xing”(‘Style and Temperament’)in Wenxin diaolong(The Literary Mind and the Carving of Dragons). Natural scenery, astronomy, his country and people, romance, kin relationships, and friendships, as well as literature and art, science and technology, all provide him with an inexhaustible source of material to draw on. The title of his first book is!Pan yuegui de haizi(The Child Who Plucks the Laurel,1975), in which“pan,”also meaning“climb,”is the key to understanding him. He is a remarkable mountain climber and swimmer, and once practised karate. He is full of vim and vigour, which he brings to bear on his studies and writing activities. Dedicated to scaling the heights of literature, he has written numerous sublime long poems as well as essays in the grand style, attaining an outstanding level of excellence, which can be described, in Liu Xie’s words, as“perspicacity like the sun and moon hanging in the sky, language like the fecund mountains and seas.”He has a good command of seven foreign languages, has imbibed the quintessence of literature, is well versed in learning, whether ancient or modern, Chinese or Western, and has a superior style of classical elegance of his own. His works are marked by compactness of texture, richness of content, and a multitudinous diversity, embracing both masculine grandeur and delicate beauty. In the world of literature in

  18. Comparison between Hilbert-Huang transform and scalogram methods on non-stationary biomedical signals: application to laser Doppler flowmetry recordings

    International Nuclear Information System (INIS)

    Roulier, Remy; Humeau, Anne; Flatley, Thomas P; Abraham, Pierre

    2005-01-01

    A significant transient increase in laser Doppler flowmetry (LDF) signals is observed in response to a local and progressive cutaneous pressure application on healthy subjects. This reflex may be impaired in diabetic patients. The work presents a comparison between two signal processing methods that provide a clarification of this phenomenon. Analyses by the scalogram and the Hilbert-Huang transform (HHT) of LDF signals recorded at rest and during a local and progressive cutaneous pressure application are performed on healthy and type 1 diabetic subjects. Three frequency bands, corresponding to myogenic, neurogenic and endothelial related metabolic activities, are studied at different time intervals in order to take into account the dynamics of the phenomenon. The results show that both the scalogram and the HHT methods lead to the same conclusions concerning the comparisons of the myogenic, neurogenic and endothelial related metabolic activities-during the progressive pressure and at rest-in healthy and diabetic subjects. However, the HHT shows more details that may be obscured by the scalogram. Indeed, the non-locally adaptative limitations of the scalogram can remove some definition from the data. These results may improve knowledge on the above-mentioned reflex as well as on non-stationary biomedical signal processing methods

  19. Epileptic Seizure Detection based on Wavelet Transform Statistics Map and EMD Method for Hilbert-Huang Spectral Analyzing in Gamma Frequency Band of EEG Signals

    Directory of Open Access Journals (Sweden)

    Morteza Behnam

    2015-08-01

    Full Text Available Seizure detection using brain signal (EEG analysis is the important clinical methods in drug therapy and the decisions before brain surgery. In this paper, after signal conditioning using suitable filtering, the Gamma frequency band has been extracted and the other brain rhythms, ambient noises and the other bio-signal are canceled. Then, the wavelet transform of brain signal and the map of wavelet transform in multi levels are computed. By dividing the color map to different epochs, the histogram of each sub-image is obtained and the statistics of it based on statistical momentums and Negentropy values are calculated. Statistical feature vector using Principle Component Analysis (PCA is reduced to one dimension. By EMD algorithm and sifting procedure for analyzing the data by Intrinsic Mode Function (IMF and computing the residues of brain signal using spectrum of Hilbert transform and Hilbert – Huang spectrum forming, one spatial feature based on the Euclidian distance for signal classification is obtained. By K-Nearest Neighbor (KNN classifier and by considering the optimal neighbor parameter, EEG signals are classified in two classes, seizure and non-seizure signal, with the rate of accuracy 76.54% and with variance of error 0.3685 in the different tests.

  20. Non-Destructive Detection of Wire Rope Discontinuities from Residual Magnetic Field Images Using the Hilbert-Huang Transform and Compressed Sensing

    Directory of Open Access Journals (Sweden)

    Juwei Zhang

    2017-03-01

    Full Text Available Electromagnetic methods are commonly employed to detect wire rope discontinuities. However, determining the residual strength of wire rope based on the quantitative recognition of discontinuities remains problematic. We have designed a prototype device based on the residual magnetic field (RMF of ferromagnetic materials, which overcomes the disadvantages associated with in-service inspections, such as large volume, inconvenient operation, low precision, and poor portability by providing a relatively small and lightweight device with improved detection precision. A novel filtering system consisting of the Hilbert-Huang transform and compressed sensing wavelet filtering is presented. Digital image processing was applied to achieve the localization and segmentation of defect RMF images. The statistical texture and invariant moment characteristics of the defect images were extracted as the input of a radial basis function neural network. Experimental results show that the RMF device can detect defects in various types of wire rope and prolong the service life of test equipment by reducing the friction between the detection device and the wire rope by accommodating a high lift-off distance.

  1. 2015 Revolving Loan Fund Supplemental Awards for Brownfields and Land Revitalization in New England

    Science.gov (United States)

    Communities in CT, ME, MA and VT will receive additional grants of $4.3 million in revolving loan fund (RLF) supplemental funding to carry out cleanup and redevelopment projects at contaminated Brownfields properties. See a list of recipients for 2015.

  2. Millennium Ecosystem Assessment: MA Rapid Land Cover Change

    Data.gov (United States)

    National Aeronautics and Space Administration — The Millennium Ecosystem Assessment: MA Rapid Land Cover Change provides data and information on global and regional land cover change in raster format for...

  3. HoCaMA: Home Care Hybrid Multiagent Architecture

    Science.gov (United States)

    Fraile, Juan A.; Bajo, Javier; Abraham, Ajith; Corchado, Juan M.

    Home Care is one of the main objectives of Ambient Intelligence. Nowadays, the disabled and elderly population, which represents a significant part of our society, requires novel solutions for providing home care in an effective way. In this chapter, we present HoCaMA, a hybrid multiagent architecture that facilitates remote monitoring and care services for disabled patients at their homes. HoCaMA combines multiagent systems and Web services to facilitate the communication and integration with multiple health care systems. In addition, HoCaMA focuses on the design of reactive agents capable of interacting with different sensors present in the environment, and incorporates a system of alerts through SMS and MMS mobile technologies. Finally, it uses Radio Frequency IDentification and JavaCard technologies to provide advanced location and identification systems, as well as automatic access control facilities. HoCaMA has been implemented in a real environment and the results obtained are presented within this chapter.

  4. Contact Aligner 2 (Front Side): Suss Microtec MA8

    Data.gov (United States)

    Federal Laboratory Consortium — Description:CORAL Name: SussMA8This system utilizes 1X contact lithography to transfer photomask patterns onto substrates Specifications / Capabilities:UV broadband...

  5. Upbeat nystagmus in anti-Ma2 encephalitis.

    Science.gov (United States)

    Garcia-Reitboeck, Pablo; Thompson, Graham; Johns, Paul; Al Wahab, Yasir; Omer, Salah; Griffin, Colette

    2014-02-01

    Anti-Ma2 encephalitis is a paraneoplastic disorder characterised by brainstem and/or limbic involvement. Eye movement abnormalities can occur in this condition, often with confusion or somnolence. We describe a patient with progressive oscillopsia (with upbeat nystagmus) and unsteadiness, followed by acute pancreatitis. She did not respond to immunomodulatory treatment and subsequently died of complications related to pancreatitis and sepsis. There was no tumour identified at autopsy, but the anti-Ma2 antibodies in her serum and the discovery of a brainstem-predominant inflammatory infiltrate at autopsy strongly suggest a paraneoplastic disorder. Our case illustrates that upbeat nystagmus can be a predominant feature in anti-Ma2 encephalitis; clinicians should consider testing for anti-Ma2 antibodies in patients with upbeat nystagmus of unknown cause.

  6. Iron supplements (image)

    Science.gov (United States)

    The mineral iron is an essential nutrient for humans because it is part of blood cells, which carry oxygen to all body cells. There is no conclusive evidence that iron supplements contribute to heart attacks.

  7. Multivitamin/Mineral Supplements

    Science.gov (United States)

    ... dietary supplements, making it hard to identify any benefits from the MVMs. Should I take an MVM? MVMs cannot take the place of eating a variety of foods that are important to a healthy diet. Foods ...

  8. Supplements to Textbook Materials.

    Science.gov (United States)

    Holmes, Ken

    1994-01-01

    Describes the many kinds of materials that English teachers can draw upon to enrich and expand students' experiences with literature. Outlines ancillary materials used to supplement the study of William Shakespeare's "Julius Caesar." (HB)

  9. Dietary Supplement Fact Sheets

    Science.gov (United States)

    ... Primary Mitochondrial Disorders Weight Loss A Acai Aloe Vera Anabolic Steroids Antioxidants (see Exercise and Athletic Performance ) ... Pills (see Weight Loss ) Dietary Supplements Vitamin D E Echinacea Ephedra Essiac/Flor-Essence European Elder Evening ...

  10. Dietary Supplement Ingredient Database

    Science.gov (United States)

    ... and US Department of Agriculture Dietary Supplement Ingredient Database Toggle navigation Menu Home About DSID Mission Current ... values can be saved to build a small database or add to an existing database for national, ...

  11. MaNGA: Mapping Nearby Galaxies at Apache Point Observatory

    Science.gov (United States)

    Weijmans, A.-M.; MaNGA Team

    2016-10-01

    MaNGA (Mapping Nearby Galaxies at APO) is a galaxy integral-field spectroscopic survey within the fourth generation Sloan Digital Sky Survey (SDSS-IV). It will be mapping the composition and kinematics of gas and stars in 10,000 nearby galaxies, using 17 differently sized fiber bundles. MaNGA's goal is to provide new insights in galaxy formation and evolution, and to deliver a local benchmark for current and future high-redshift studies.

  12. Antioxidant supplements and mortality

    DEFF Research Database (Denmark)

    Bjelakovic, Goran; Nikolova, Dimitrinka; Gluud, Christian

    2014-01-01

    Oxidative damage to cells and tissues is considered involved in the aging process and in the development of chronic diseases in humans, including cancer and cardiovascular diseases, the leading causes of death in high-income countries. This has stimulated interest in the preventive potential of a...... of antioxidant supplements. Today, more than one half of adults in high-income countries ingest antioxidant supplements hoping to improve their health, oppose unhealthy behaviors, and counteract the ravages of aging....

  13. Vitamin and Mineral Supplement Fact Sheets

    Science.gov (United States)

    ... website Submit Search NIH Office of Dietary Supplements Vitamin and Mineral Supplement Fact Sheets Search the list ... Supplements: Background Information Botanical Dietary Supplements: Background Information Vitamin and Mineral Fact Sheets Botanical Supplement Fact Sheets ...

  14. [Anti-Ma2-associated encephalitis and paraneoplastic limbic encephalitis].

    Science.gov (United States)

    Yamamoto, Tomotaka; Tsuji, Shoji

    2010-08-01

    Anti-Ma2-associated encephalitis (or anti-Ma2 encephalitis) is a paraneoplastic neurological syndrome (PNS) characterized by isolated or combined limbic, diencephalic, or brainstem dysfunction. Anti-Ma2 antibodies detected in the serum or cerebrospinal fluid of patients are highly specific for this disease entity and belong to a group of well-characterized onconeuronal antibodies (or classical antibodies). The corresponding antigen, Ma2 is selectively expressed intracellularly in neurons and tumors as is the case with other onconeuronal antigens targeted by classical antibodies. However, in most cases the clinical pictures are different from those of classical PNS and this creates a potential risk of underdiagnosis. Although limbic dysfunction is the most common manifestation in patients with anti-Ma2 encephalitis which is one of the major causes of paraneoplastic limbic encephalitis (LE), it has been reported that less than 30% of the patients with anti-Ma2 LE exhibit clinical presentations typical of the classical description of LE. Of the remaining, many exhibit excessive daytime sleepiness, vertical ophthalmoparesis, or both associated with LE, because of frequent involvement of the diencephalon and/or upper brainstem. Anti-Ma2 LE can also be manifested as a pure psychiatric disturbance such as obsessive-compulsive disorder in a few cases. Some patients develop mesodiencephalic encephalitis with minor involvement of the limbic system, and some may manifest severe hypokinesis. About 40% of the patients with anti-Ma2 antibodies also have antibodies against different epitopes on Ma1, a homologue of Ma2. These patients may have predominant cerebellar and/or brainstem dysfunctions due to more extensive involvement of subtentorial structures. Anti-Ma2 encephalitis is outstanding among other PNS associated with classical antibodies in that the response rate to treatment is relatively high. While it can cause severe neurological deficits or death in a substantial

  15. Active components in food supplements

    NARCIS (Netherlands)

    Siemelink M; Jansen EHJM; Piersma AH; Opperhuizen A; LEO

    2000-01-01

    The growing food supplement market, where supplements are both more diverse and more easily available (e.g. through Internet) formed the backdrop to the inventory of the active components in food supplements. The safety of an increased intake of food components via supplements was also at issue

  16. Increase in physical activities in kindergarten children with cerebral palsy by employing MaKey-MaKey-based task systems.

    Science.gov (United States)

    Lin, Chien-Yu; Chang, Yu-Ming

    2014-09-01

    In this study, we employed Flash- and Scratch-based multimedia by using a MaKey-MaKey-based task system to increase the motivation level of children with cerebral palsy to perform physical activities. MaKey MaKey is a circuit board that converts physical touch to a digital signal, which is interpreted by a computer as a keyboard message. In this study, we used conductive materials to control this interaction. This study followed single-case design using ABAB models in which A indicated the baseline and B indicated the intervention. The experiment period comprised 1 month and a half. The experimental results demonstrated that in the case of two kindergarten children with cerebral palsy, their scores were considerably increased during the intervention phrases. The developmental applications of the results are also discussed. Copyright © 2014 Elsevier Ltd. All rights reserved.

  17. Texture and anisotropy of the mechanical properties of MA14 and MA2-1 alloys produced by granular metallurgy

    Science.gov (United States)

    Betsofen, S. Ya.; Konkevich, V. Yu.; Osintsev, O. E.; Avdyukhina, A. A.; Voskresenskaya, I. I.; Grushin, I. A.

    2015-10-01

    The contribution of texture to the anisotropy of the mechanical properties of semifinished products from MA14 and MA2-1 alloys prepared by capsule-free pressing of granules is quantitatively evaluated using inverse pole figures and calculated Taylor orientation factors for basal slip. It is shown that the texture intensity and the anisotropy of the mechanical properties of the pressed semiproducts are lower than those of the semiproducts from an ingot and the compressive yield strength is substantially higher.

  18. Inszenierung eines Supplements / Staging a Supplement

    Directory of Open Access Journals (Sweden)

    Thomas-M. Seibert

    2006-06-01

    Full Text Available Richter Adam, Anwalt Liebling und William, der Detektiv. Die Rechtspraxis setzt etwas voraus, das sie nicht nur begründet oder ergänzt, sondern grundsätzlich in Frage stellt. So macht der Zwang, in einem Verfahren zu entscheiden und zu begründen, zugleich deutlich, dass jede Form der Entscheidung unangemessen, unbegründet und in ganz anderer Weise neu herzustellen ist. Das ist das juridische Supplement im Geiste von Jacques Derrida. Supplementiert wird die Wahrheit des Rechts in anderen Medien: in Drama, Film und Literatur etwa. Dort wird in Szene gesetzt, was in der real erlebbaren Rechtswelt nicht wirklich erlebt werden kann, was aber doch – wie kein Amtsträger bestreiten würde – zum Verfahrensergebnis gehört. Judge Adam, Advocate “Liebling” and William, the Detective. Legal practice is based on something that is not only an integral part of it and complements it, but also puts it into question generally. The compulsion to argue and reach decisions in a legal trial clarifies simultaneously that all forms of decision are inapproprate, unreasonable, and can be recreated in an entirely new manner [to suit the needs of the trial]. This is the legalistic supplement in the spirit of Jacques Derrida. The legal truth is supplemented by other forms of media such as drama, film and literature, which are able to stage scenes that cannot be experienced in a real life legal world, but – as no legal official would deny – are an integral part of the trial and verdict procedure.

  19. Rhein 8-O-β-D-Glucopyranoside Elicited the Purgative Action of Daiokanzoto (Da-Huang-Gan-Cao-Tang), Despite Dysbiosis by Ampicillin.

    Science.gov (United States)

    Takayama, Kento; Tabuchi, Norihiko; Fukunaga, Masahito; Okamura, Nobuyuki

    2016-01-01

    Sennoside A (SA), the main purgative constituent of Daiokanzoto (da-huang-gan-cao-tang; DKT), is generally regarded as a prodrug that is transformed into an active metabolite by β-glucosidase derived from Bifidobacterium spp. It has been suggested that antibiotics would promote dysbiosis, and thereby inhibit the purgative activity of DKT. In this study, ampicillin was administered to mice for 8 d, and the changes in the SA metabolism of SA alone and of DKT were investigated. The results showed that the SA metabolism of SA singly continued to be inhibited by ampicillin, but that of DKT was activated from day 3 under the same conditions. In order to investigate the mechanism of SA metabolism activated by DKT in the mice administered ampicillin, changes in the SA metabolism were observed in the presence of rhein 8-O-β-D-glucopyranoside (RG) in rhubarb and liquiritin in glycyrrhiza, both of which accelerated the SA metabolism. In fact, RG achieved an activation of SA metabolism similar to that by DKT. The purgative action of DKT, which was continued treatment of the ampicillin, was significantly greater than that by SA alone, and it was shown that RG was involved in this effect. We also analyzed changes in the intestinal microbiota before and after administration of ampicillin. No Bifidobacteria were detected throughout the treatment, but the population of Bacteroides was significantly increased after 3 d under the same conditions. Taken together, these results strongly suggested that the RG in DKT changed the function of Bacteroides and thereby allowed DKT to metabolize SA.

  20. Pien Tze Huang inhibits the proliferation, and induces the apoptosis and differentiation of colorectal cancer stem cells via suppression of the Notch1 pathway.

    Science.gov (United States)

    Qi, Fei; Wei, Lihui; Shen, Aling; Chen, Youqin; Lin, Jiumao; Chu, Jianfeng; Cai, Qiaoyan; Pan, Jie; Peng, Jun

    2016-01-01

    Cancer stem cells (CSCs) possess properties of continuous self-renewal, multi-directional differentiation and natural chemoresistance, leading to the initiation, progression and relapse of cancer. The characteristics of CSCs are strongly associated with multiple cellular pathways such as Notch1 signaling. Therefore, targeting CSCs via suppressing the Notch1 pathway might represent a promising strategy for cancer treatment. The well-known traditional Chinese medicine (TCM) formula Pien Tze Huang (PZH) has long been used as an alternative remedy for various cancers including colorectal cancer (CRC). We previously reported that PZH contains a broad range of anticancer activities including an inhibitory effect on CSCs. To further elucidate the mode of action of PZH, in this study we isolated the stem-like side population (SP) from the human CRC SW480 cell line to investigate its effect on CSCs as well as the possible molecular mechanisms. As compared with non-SP cells, the isolated SW480 SP cells displayed stronger capacities of spheroid formation in vitro and tumorigenicity in vivo, demonstrating the stem cell-like features of SP cells. However, PZH treatment significantly decreased the percentage of SP cells in a dose-dependent manner. In addition, PZH significantly and does-dependently inhibited the viability and promoted the apoptosis and differentiation of the isolated SW480 SP cells. Moreover, PZH treatment profoundly reduced the mRNA and protein expression of Notch1 and Hes1 in the SP cells. Our findings suggest that PZH negatively modulates the characteristics of CSCs through suppression of the Notch1 signaling pathway.

  1. Preconditioning with the traditional Chinese medicine Huang-Lian-Jie-Du-Tang initiates HIF-1α-dependent neuroprotection against cerebral ischemia in rats.

    Science.gov (United States)

    Zhang, Qichun; Bian, Huimin; Li, Yu; Guo, Liwei; Tang, Yuping; Zhu, Huaxu

    2014-06-11

    Huang-Lian-Jie-Du-Tang (HLJDT) is a classical heat-clearing and detoxicating formula of traditional Chinese medicine that is widely used to treat stroke. The present study was designed to investigate the effects of HLJDT preconditioning on neurons under oxygen and glucose deprivation (OGD) and rats subjected to middle cerebral artery occlusion (MCAO). A stroke model of rats was obtained through MCAO. Following HLJDT preconditioning, the cerebral infarction volume, cerebral water content, and neurological deficient score were determined. Cerebral cortical neurons cultured in vitro were preconditioned with HLJDT and then subjected to OGD treatment. The release of lactate dehydrogenase (LDH) from neurons was detected. The levels of hypoxia-inducible factor-1α (HIF-1α) and PI3K/Akt signaling were analyzed by western blotting, and the levels of erythropoietin (EPO) and vascular endothelial growth factor (VEGF) in the supernatant of the neurons and the plasma of MCAO rats were measured through a radioimmunological assay. The apoptosis and proliferation of neurons were analyzed by immunohistochemistry. HLJDT preconditioning significantly reduced the cerebral infarction volume and cerebral water content and ameliorated the neurological deficient score of MCAO rats. In addition, HLJDT preconditioning protected neurons against OGD. Increased HIF-1α, EPO, and VEGF levels and the activation of PI3K/Akt signaling were observed as a result of HLJDT preconditioning. Furthermore, HLJDT preconditioning was found to inhibit ischemia-induced neuron apoptosis and to promote neuron proliferation under conditions of ischemia/reperfusion. Both rats and neurons subjected to HLJDT preconditioning were able to resist ischemia/reperfusion or hypoxia injury through the inhibition of apoptosis and the enhancement of proliferation, and these effects were primarily dependent on the activation of the PI3K/Akt signaling pathway and HIF-1α. Copyright © 2014 Elsevier Ireland Ltd. All rights

  2. San-Huang-Xie-Xin-Tang Prevents Rat Hearts from Ischemia/Reperfusion-Induced Apoptosis through eNOS and MAPK Pathways

    Directory of Open Access Journals (Sweden)

    Shu-Fen Liou

    2011-01-01

    Full Text Available San-Huang-Xie-Xin-Tang (SHXT is a traditional Chinese medication consisting of three herbs, namely Coptidis rhizome, Scutellariae radix and Rhei rhizome. This study aimed to examine the cardioprotective effects of SHXT in a rat model of acute myocardial apoptosis induced by ischemia/reperfusion (I/R. Vehicle (intravenous saline or SHXT (intravenous or oral was administered prior to I/R (occlusion of left coronary artery for 45 min followed by reperfusion for 2 h. In the vehicle group, myocardial I/R caused myocardial infarction with increased plasma cardiac enzymes, severe arrhythmia and mortality. Myocardial apoptosis was induced by I/R as evidenced by DNA ladder and Bcl-2/Bax ratio. In the SHXT group, we found that SHXT significantly reduced plasma levels of cardiac enzymes, arrhythmia scores (from 5 ± 1 to 2 ± 1, P<.01 and mortality rate (from 53 to 0%, P<.01. In addition, pretreatment with intravenous SHXT reduced the infarct size dose-dependently when compared with the vehicle group (10 mg kg−1: 14.0 ± 0.2 versus 44.5 ± 5.0%, and 30 mg kg−1: 6.2 ± 1.2% versus 44.5 ± 5.0%, both P<.01. Similarly, oral administration of SHXT reduced the infarct size dose-dependently. Furthermore, SHXT markedly decreased the apoptosis induced by I/R with increased Bcl-2/Bax ratio. Finally, we found that SHXT counteracted the I/R-induced downstream signaling, resulting in increased myocardial eNOS expression and plasma nitrite, and decreased activation of ERK1/2, p38 and JNK. These data suggest that SHXT has cardioprotective effects against I/R-induced apoptosis, and that these effects are mediated, at least in part, by eNOS and MAPK pathways.

  3. Effect of various absorption enhancers based on tight junctions on the intestinal absorption of forsythoside A in Shuang-Huang-Lian, application to its antivirus activity.

    Science.gov (United States)

    Zhou, Wei; Zhu, Xuan Xuan; Yin, Ai Ling; Cai, Bao Chang; Wang, Hai Dan; Di, Liuqing; Shan, Jin Jun

    2014-01-01

    Forsythoside A (FTA), one of the main active ingredients in Shuang-Huang-Lian (SHL), possesses strong antibacterial, antioxidant and antiviral effects, and its pharmacological effects was higher than that of other ingredients, but the absolute bioavailability orally was approximately 0.72%, which was significantly low, influencing clinical efficacies of its oral preparations seriously. In vitro Caco-2 cell and in vivo pharmacokinetics study were simultaneously performed to investigate the effects of absorption enhancers based on tight junctions: sodium caprate and water-soluble chitosan on the intestinal absorption of FTA, and the eventual mucosal epithelial damage resulted from absorption enhancers was evaluated by MTT test and morphology observation, respectively. The pharmacological effects such as antivirus activity improvement by absorption enhancers were verified by MDCK damage inhibition rate after influenza virus propagation. The observations from in vitro Caco-2 cell showed that the absorption of FTA in SHL could be improved by absorption enhancers. Meanwhile, the absorption enhancing effect of water-soluble chitosan may be almost saturable up to 0.0032% (w/v), and sodium caprate at concentrations up to 0.64 mg/mL was safe, but water-soluble chitosan at different concentrations was all safe for these cells. In pharmacokinetics study, water-soluble chitosan at dosage of 50 mg/kg improved the bioavailability of FTA in SHL to the greatest extent, and was safe for gastrointestine from morphological observation. Besides, treatment with SHL with water-soluble chitosan at dosage of 50 mg/kg prevented MDCK damage after influenza virus propagation better significantly than that of control. Water-soluble chitosan at dosage of 50 mg/kg might be safe and effective absorption enhancer for improving the bioavailability of FTA and the antivirus activity in vitro in SHL.

  4. Diet of Theropithecus from 4 to 1 Ma in Kenya.

    Science.gov (United States)

    Cerling, Thure E; Chritz, Kendra L; Jablonski, Nina G; Leakey, Meave G; Manthi, Fredrick Kyalo

    2013-06-25

    Theropithecus was a common large-bodied primate that co-occurred with hominins in many Plio-Pleistocene deposits in East and South Africa. Stable isotope analyses of tooth enamel from T. brumpti (4.0-2.5 Ma) and T. oswaldi (2.0-1.0 Ma) in Kenya show that the earliest Theropithecus at 4 Ma had a diet dominated by C4 resources. Progressively, this genus increased the proportion of C4-derived resources in its diet and by 1.0 Ma, had a diet that was nearly 100% C4-derived. It is likely that this diet was comprised of grasses or sedges; stable isotopes cannot, by themselves, give an indication of the relative importance of leaves, seeds, or underground storage organs to the diet of this primate. Theropithecus throughout the 4- to 1-Ma time range has a diet that is more C4-based than contemporaneous hominins of the genera Australopithecus, Kenyanthropus, and Homo; however, Theropithecus and Paranthropus have similar proportions of C4-based resources in their respective diets.

  5. Treatment of anti-Ma2/Ta paraneoplastic syndrome.

    Science.gov (United States)

    Kraker, Jessica

    2009-01-01

    The paraneoplastic syndrome caused by Ma2/Ta antibodies alone (not in conjunction with Ma1 or Ma3 antibodies) varies in presentation from classic limbic encephalitis. The Ma2 syndrome may present with symptoms referable to the brainstem, diencephalon, and limbic system. These clinical symptoms are accompanied by MRI changes and abnormal electroencephalographic findings. It is important to recognize when the encephalitic syndrome is secondary to Ma2 paraneoplastic antibodies, as the patients improve or stabilize most often when the underlying carcinoma is treated. Treatment of the paraneoplastic syndrome begins with recognition of the symptoms, such as memory impairment, seizures, sleep disturbances, bradykinesia or hypokinesia, and eye movement abnormalities. If a primary tumor is discovered during the workup, it should be removed and treated with the most up-to-date oncologic treatment available. In addition to oncologic treatment, the syndrome may be treated with an immunosuppressant regimen to optimize the neurologic outcome. Leaving the patient untreated will result in decline and eventual death from the cancer itself or from complications of the paraneoplastic syndrome.

  6. Large area imaging of forensic evidence with MA-XRF.

    Science.gov (United States)

    Langstraat, Kirsten; Knijnenberg, Alwin; Edelman, Gerda; van de Merwe, Linda; van Loon, Annelies; Dik, Joris; van Asten, Arian

    2017-11-08

    This study introduces the use of macroscopic X-ray fluorescence (MA-XRF) for the detection, classification and imaging of forensic traces over large object areas such as entire pieces of clothing and wall paneling. MA-XRF was sufficiently sensitive and selective to detect human biological traces like blood, semen, saliva, sweat and urine on fabric on the basis of Fe, Zn, K, Cl and Ca elemental signatures. With MA-XRF a new chemical contrast is introduced for human stain detection and this can provide a valuable alternative when the evidence item is challenging for conventional techniques. MA-XRF was also successfully employed for the chemical imaging and classification of gunshot residues (GSR). The full and non-invasive elemental mapping (Pb, Ba, Sr, K and Cl) of intact pieces of clothing allows for a detailed shooting incident reconstruction linking firearms and ammunition to point of impact and providing information on the shooting angle. In high resolution mode MA-XRF can even be used to provide information on the shooting order of different ammunition types. Finally, by using the surface penetration of X-rays we demonstrate that the lead signature of a bullet impact can be easily detected even if covered by multiple layers of wall paint or human blood.

  7. Changing the Safety and Mission Assurance (S and MA) Paradigm

    Science.gov (United States)

    Malone, Roy W.; Safie, Fayssal M.

    2010-01-01

    This slide presentation reviews the change in the work and impact of the Safety and Mission Assurance directorate at Marshall Space Flight Center. It reviews the background and the reasons given for a strong Safety & Mission Assurance presence in all planning for space flight. This was pointed out by the Rogers Commission Report after the Space Challenger accident, by the Columbia Accident Investigation Board (CAIB) and by a 2006 NASA Exploration Safety Study (NESS) Team. The overall objective of the work in this area was to improve and maintain S&MA expertise and skills. Training for this work was improved and the S&MA organization was reorganized. This has resulted in a paradigm shift for NASA's safety efforts, which is described. The presentation then reviews the impact of the new S&MA work in the Ares I design and development.

  8. Effects of Lactobacillus plantarum MA2 isolated from Tibet kefir on lipid metabolism and intestinal microflora of rats fed on high-cholesterol diet.

    Science.gov (United States)

    Wang, Yanping; Xu, Nv; Xi, Aodeng; Ahmed, Zaheer; Zhang, Bin; Bai, Xiaojia

    2009-08-01

    The objective of this study was to evaluate the effects of Lactobacillus plantarum MA2, an isolate from Chinese traditional Tibet kefir, on cholesterol-lowering and microflora of rat in vivo. Rats were fed on cholesterol-enriched experimental diet, supplemented with lyophilized L. plantarum MA2 powder, with a dose of 10(11) cells/day per mice. The results showed that L. plantarum MA2 feeding significantly lowered serum total cholesterol, low-density lipoprotein cholesterol, and triglycerides level, while there was no change in high-density lipoprotein cholesterol. In addition, liver total cholesterol and triglycerides was also decreased. However, fecal cholesterol and triglycerides was increased significantly (P MA2 increased the population of lactic acid bacteria and bifidobacteria in the fecal, but it did not change the number of Escherichia coli as compared to control. Moreover, pH, moisture, and organic acids in the fecal were also measured. The present results indicate the probiotic potential of the L. plantarum MA2 strain in hypocholesterolemic effect and also increasing the probiotic count in the intestine.

  9. Comprehensive analysis of NuMA variation in breast cancer

    Directory of Open Access Journals (Sweden)

    Aittomäki Kristiina

    2008-03-01

    Full Text Available Abstract Background A recent genome wide case-control association study identified NuMA region on 11q13 as a candidate locus for breast cancer susceptibility. Specifically, the variant Ala794Gly was suggested to be associated with increased risk of breast cancer. Methods In order to evaluate the NuMa gene for breast cancer susceptibility, we have here screened the entire coding region and exon-intron boundaries of NuMa in 92 familial breast cancer patients and constructed haplotypes of the identified variants. Five missense variants were further screened in 341 breast cancer cases with a positive family history and 368 controls. We examined the frequency of Ala794Gly in an extensive series of familial (n = 910 and unselected (n = 884 breast cancer cases and controls (n = 906, with a high power to detect the suggested breast cancer risk. We also tested if the variant is associated with histopathologic features of breast tumors. Results Screening of NuMA resulted in identification of 11 exonic variants and 12 variants in introns or untranslated regions. Five missense variants that were further screened in breast cancer cases with a positive family history and controls, were each carried on a unique haplotype. None of the variants, or the haplotypes represented by them, was associated with breast cancer risk although due to low power in this analysis, very low risk alleles may go unrecognized. The NuMA Ala794Gly showed no difference in frequency in the unselected breast cancer case series or familial case series compared to control cases. Furthermore, Ala794Gly did not show any significant association with histopathologic characteristics of the tumors, though Ala794Gly was slightly more frequent among unselected cases with lymph node involvement. Conclusion Our results do not support the role of NuMA variants as breast cancer susceptibility alleles.

  10. Comprehensive analysis of NuMA variation in breast cancer

    International Nuclear Information System (INIS)

    Kilpivaara, Outi; Rantanen, Matias; Tamminen, Anitta; Aittomäki, Kristiina; Blomqvist, Carl; Nevanlinna, Heli

    2008-01-01

    A recent genome wide case-control association study identified NuMA region on 11q13 as a candidate locus for breast cancer susceptibility. Specifically, the variant Ala794Gly was suggested to be associated with increased risk of breast cancer. In order to evaluate the NuMa gene for breast cancer susceptibility, we have here screened the entire coding region and exon-intron boundaries of NuMa in 92 familial breast cancer patients and constructed haplotypes of the identified variants. Five missense variants were further screened in 341 breast cancer cases with a positive family history and 368 controls. We examined the frequency of Ala794Gly in an extensive series of familial (n = 910) and unselected (n = 884) breast cancer cases and controls (n = 906), with a high power to detect the suggested breast cancer risk. We also tested if the variant is associated with histopathologic features of breast tumors. Screening of NuMA resulted in identification of 11 exonic variants and 12 variants in introns or untranslated regions. Five missense variants that were further screened in breast cancer cases with a positive family history and controls, were each carried on a unique haplotype. None of the variants, or the haplotypes represented by them, was associated with breast cancer risk although due to low power in this analysis, very low risk alleles may go unrecognized. The NuMA Ala794Gly showed no difference in frequency in the unselected breast cancer case series or familial case series compared to control cases. Furthermore, Ala794Gly did not show any significant association with histopathologic characteristics of the tumors, though Ala794Gly was slightly more frequent among unselected cases with lymph node involvement. Our results do not support the role of NuMA variants as breast cancer susceptibility alleles

  11. Avatares tántricos de Râma

    OpenAIRE

    Muñoz, Adrián

    2009-01-01

    Si bien el poema épico del Râmâyana es considerado como uno de los pilares literarios del hinduismo, no se trata de un texto fijo, pues la trama ha generado diversas versiones alternas en el sur y el sureste asiáticos. Al mismo tiempo, aunque Râma representa ideales sociales fundamentales para la ortodoxia hinduista, otras corrientes religiosas no ortodoxas han recurrido a y adaptado la figura de Râma. Este ensayo busca valorar en particular las manifestaciones tántricas y pseudo-tántrica...

  12. Psychology: Teacher Supplement.

    Science.gov (United States)

    Stark, Rebecca

    This supplement provides teachers with tests, quizzes, answers to questions in the text, and general teaching information for using the student text, "Psychology," by Rebecca Stark. Quizzes included are on the topics of human development; the nervous system; the brain; cognitive development; sensation and perception; conditioning; learning;…

  13. Supplementation in Rats

    African Journals Online (AJOL)

    Erah

    We therefore designed this study to measure thoracic aortic ring .... contraction obtained from pilot study (1 x 10-6. M for control and 1 x .... muscle cell hyperpolarisation20. Similarly, several reports have suggested that potassium supplementation enhances endothelium- dependent relaxations, increased vascular activity of ...

  14. Should You Take Dietary Supplements?

    Science.gov (United States)

    ... 2013 Print this issue Should You Take Dietary Supplements? A Look at Vitamins, Minerals, Botanicals and More ... Gut in Check Wise Choices Safe Use of Supplements Tell all of your health care providers about ...

  15. 2017 Annual Disability Statistics Supplement

    Science.gov (United States)

    Lauer, E. A; Houtenville, A. J.

    2018-01-01

    The "Annual Disability Statistics Supplement" is a companion report to the "Annual Disability Statistics Compendium." The "Supplement" presents statistics on the same topics as the "Compendium," with additional categorizations by demographic characteristics including age, gender and race/ethnicity. In…

  16. 42 CFR 422.52 - Eligibility to elect an MA plan for special needs individuals.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Eligibility to elect an MA plan for special needs..., and Enrollment § 422.52 Eligibility to elect an MA plan for special needs individuals. (a) General rule. In order to elect a specialized MA plan for a special needs individual (Special Needs MA plan, or...

  17. Lipidomics study of plasma phospholipid metabolism in early type 2 diabetes rats with ancient prescription Huang-Qi-San intervention by UPLC/Q-TOF-MS and correlation coefficient.

    Science.gov (United States)

    Wu, Xia; Zhu, Jian-Cheng; Zhang, Yu; Li, Wei-Min; Rong, Xiang-Lu; Feng, Yi-Fan

    2016-08-25

    Potential impact of lipid research has been increasingly realized both in disease treatment and prevention. An effective metabolomics approach based on ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS) along with multivariate statistic analysis has been applied for investigating the dynamic change of plasma phospholipids compositions in early type 2 diabetic rats after the treatment of an ancient prescription of Chinese Medicine Huang-Qi-San. The exported UPLC/Q-TOF-MS data of plasma samples were subjected to SIMCA-P and processed by bioMark, mixOmics, Rcomdr packages with R software. A clear score plots of plasma sample groups, including normal control group (NC), model group (MC), positive medicine control group (Flu) and Huang-Qi-San group (HQS), were achieved by principal-components analysis (PCA), partial least-squares discriminant analysis (PLS-DA) and orthogonal partial least-squares discriminant analysis (OPLS-DA). Biomarkers were screened out using student T test, principal component regression (PCR), partial least-squares regression (PLS) and important variable method (variable influence on projection, VIP). Structures of metabolites were identified and metabolic pathways were deduced by correlation coefficient. The relationship between compounds was explained by the correlation coefficient diagram, and the metabolic differences between similar compounds were illustrated. Based on KEGG database, the biological significances of identified biomarkers were described. The correlation coefficient was firstly applied to identify the structure and deduce the metabolic pathways of phospholipids metabolites, and the study provided a new methodological cue for further understanding the molecular mechanisms of metabolites in the process of regulating Huang-Qi-San for treating early type 2 diabetes. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  18. Instantaneous 3D EEG Signal Analysis Based on Empirical Mode Decomposition and the Hilbert–Huang Transform Applied to Depth of Anaesthesia

    Directory of Open Access Journals (Sweden)

    Mu-Tzu Shih

    2015-02-01

    Full Text Available Depth of anaesthesia (DoA is an important measure for assessing the degree to which the central nervous system of a patient is depressed by a general anaesthetic agent, depending on the potency and concentration with which anaesthesia is administered during surgery. We can monitor the DoA by observing the patient’s electroencephalography (EEG signals during the surgical procedure. Typically high frequency EEG signals indicates the patient is conscious, while low frequency signals mean the patient is in a general anaesthetic state. If the anaesthetist is able to observe the instantaneous frequency changes of the patient’s EEG signals during surgery this can help to better regulate and monitor DoA, reducing surgical and post-operative risks. This paper describes an approach towards the development of a 3D real-time visualization application which can show the instantaneous frequency and instantaneous amplitude of EEG simultaneously by using empirical mode decomposition (EMD and the Hilbert–Huang transform (HHT. HHT uses the EMD method to decompose a signal into so-called intrinsic mode functions (IMFs. The Hilbert spectral analysis method is then used to obtain instantaneous frequency data. The HHT provides a new method of analyzing non-stationary and nonlinear time series data. We investigate this approach by analyzing EEG data collected from patients undergoing surgical procedures. The results show that the EEG differences between three distinct surgical stages computed by using sample entropy (SampEn are consistent with the expected differences between these stages based on the bispectral index (BIS, which has been shown to be quantifiable measure of the effect of anaesthetics on the central nervous system. Also, the proposed filtering approach is more effective compared to the standard filtering method in filtering out signal noise resulting in more consistent results than those provided by the BIS. The proposed approach is therefore

  19. [Comparison of Curative Effect between Fu Fang Huang Dai Pian and Arsenic Trioxide in Treatment of 45 Patients with Acute Promyelocytic Leukaemia].

    Science.gov (United States)

    Wang, Jian; Huang, Jun-Bin; Liu, Zu-Lin; Zhang, Bi-Hong; Xu, Hong-Gui; Xue, Hong-Man; Chen, Chun

    2017-12-01

    To investigate the clinical efficacy of Fu Fan Huang Dai Pian(RIF) and arsenic trioxide (ATO) regimens for treatment of children with acute promyelocytic leukemia (APL) and to explore the risk factors affecting the prognosis of patients. The clinical data of 45 newly diagnosed APL children admitted in our hospital from January 2004 to May 2017 were analyzed retrospectively. Among 45 APL children, 25 children were treated by chemotherapetic regimen including RIF (RIF group), another 20 children were treated by chemotherapeutic regimen including ATO (ATO group). The follow-up was performed in all APL children. The prognosis and incidence of side reactions from drugs in 2 groups were compared, and the high risk factors affecting the prognosis of patients were analyzed. The median follow-up time was 49.8% months. In RIF group, no early death occured in 25 APL children; 5 cases did not achieve complete remission (CR) after induction therapy, CR rate was 88%. Out of 25 cases 2 caes relapsed, 3 cases died, 20 cases maintained contined CR (CCR), 2 cases failed to be followed-up. In ATO group, 2 cases suffered from early death, 5 cases did not achieve CR after induction therapy, CR rate was 90%, 2 caese relapsed and died, 15 cases maintained CCR, the follow-up failed in 1 caes. The 5 year- OS and EFS rate in all the patients were predicted as (82.2±6.2)% and (76.4±6.6)% respectively. The OS and EFS rate in RIF group were (86.1±7.4)% and (78.4±8.6)% respectively, which were significantly different from OS and EFS rate (76.4%±10.6%) and (74.0%±10.1%) respectively in ATO group (all P>0.05). As for the side reaction from drug, except for the cardiac damage (P0.05). In addition, the 5 year-OS and EFS rates in APL children with CNSL were significantly lower than those in APL children without CNSL (all Phigh risk were significantly lower than those in APL children reached M1 after induction therapy and with low and standerd risk (Ptreatment of APL children. The CNSL, poor

  20. Drought evolution characteristics and precipitation intensity changes during alternating dry-wet changes in the Huang-Huai-Hai River basin

    Science.gov (United States)

    Yan, D. H.; Wu, D.; Huang, R.; Wang, L. N.; Yang, G. Y.

    2013-03-01

    According to the Chinese climate divisions and the Huang-Huai-Hai River basin digital elevation map, the basin is divided into seven sub-regions by means of cluster analysis of the basin meteorological stations using the self-organizing map (SOM) neural network method. Based on the daily precipitation data of 171 stations for the years 1961-2011, the drought frequency changes with different magnitudes are analyzed and the number of consecutive days without precipitation is used to identify the drought magnitudes. The first precipitation intensity after a drought period is analyzed with the Pearson-III frequency curve, then the relationship between rainfall intensity and different drought magnitudes is observed, as are the drought frequency changes for different years. The results of the study indicated the following: (1) the occurrence frequency of different drought level shows an overall increasing trend; there is no clear interdecadal change shown, but the spatial difference is significant. The occurrence frequencies of severe and extraordinary drought are higher on the North China Plain, Hetao Plains in Ningxia-Inner Mongolia, as well as on the Inner Mongolia and the Loess Plateaus, and in the Fen-Wei Valley basin. (2) As the drought level increases, the probability of extraordinary rainstorm becomes lower, and the frequency of occurrence of spatial changes in different precipitation intensities vary. In the areas surrounding Bo Sea, the Shandong Peninsula and the Huai River downstream, as the drought level increases, the occurrence frequency of different precipitation intensities first shows a decreasing trend, which becomes an increasing trend when extraordinary drought occurs. In the middle and upper reaches of the Huai River basin, on the Hai River basin piedmont plain and Hetao Plains in Ningxia-Inner Mongolia, Inner Mongolia and Loess Plateaus, and in the Fen-Wei Valley basin, the probability of the different precipitation intensities shows an overall

  1. Impact of thermal time shift on wheat phenology and yield under warming climate in the Huang-Huai-Hai Plain, China

    Science.gov (United States)

    Xiao, Dengpan; Qi, Yongqing; Li, Zhiqiang; Wang, Rende; Moiwo, Juana P.; Liu, Fengshan

    2017-03-01

    Given climate change can potentially influence crop phenology and subsequent yield, an investigation of relevant adaptation measures could increase the understanding and mitigation of these responses in the future. In this study, field observations at 10 stations in the Huang-Huai-Hai Plain of China (HHHP) are used in combination with the Agricultural Production Systems Simulator (APSIM)-Wheat model to determine the effect of thermal time shift on the phenology and potential yield of wheat from 1981-2009. Warming climate speeds up winter wheat development and thereby decreases the duration of the wheat growth period. However, APSIM-Wheat model simulation suggests prolongation of the period from flowering to maturity (Gr) of winter wheat by 0.2-0.8 d•10yr-1 as the number of days by which maturity advances, which is less than that by which flowering advances. Based on computed thermal time of the two critical growth phases of wheat, total thermal time from floral initiation to flowering (TT_floral_initiation) increasesd in seven out of the 10 investigated stations. Alternatively, total thermal time from the start of grainfilling to maturity (TT_start_ grain_fill) increased in all investigated stations, except Laiyang. It is thus concluded that thermal time shift during the past three decades (1981-2009) prolongs Gr by 0.2-3.0 d•10yr-1 in the study area. This suggests that an increase in thermal time (TT) of the wheat growth period is critical for mitigating the effect of growth period reduction due to warming climatic condition. Furthermore, climate change reduces potential yield of winter wheat in 80% of the stations by 2.3-58.8 kg•yr-1. However, thermal time shift (TTS) increases potential yield of winter wheat in most of the stations by 3.0-51.0 kg•yr-1. It is concluded that wheat cultivars with longer growth periods and higher thermal requirements could mitigate the negative effects of warming climate on crop production in the study area.

  2. Huang-Lian-Jie-Du-Decotion induced protective autophagy against the injury of cerebral ischemia/reperfusion via MAPK-mTOR signaling pathway.

    Science.gov (United States)

    Wang, Peng-Ran; Wang, Jun-Song; Zhang, Chao; Song, Xing-Fang; Tian, Na; Kong, Ling-Yi

    2013-08-26

    Huang-Lian-Jie-Du-Decotion (HLJDD, Hwangryun-Hae-Dok-Decotion in Japan), an ancient antipyretic and detoxifying traditional Chinese medicine formula, was reported to have protective effect on ischemic stroke. To investigate the therapeutic effect of HLJDD on ischemic stroke and explore its mode of action. A model of ischemic stroke in the rat was established after transient middle cerebral artery occlusion (MCAO) followed by reperfusion. Rats were assigned randomly to groups of control, sham, transient ischemia/reperfusion (I/R), and three treatment groups by HLJDD at 2.5, 5.0, 10.0mg/kg. The neurological deficit, the cerebral infarct size, morphology abnormality, biochemical parameters were examined, and the levels of relevant proteins were determined by immunoblotting analysis to evaluate the protective effects of HLJDD on ischemic stroke and explore the underlying mechanism. Compared with I/R group, HLJDD significantly ameliorated neurological deficit and histopathology changes, decreased infarct area, and restored the levels of biochemical indicators including nitric oxide (NO), malondialdehyde (MDA), glutathione (GSH), glutathione disulfide (GSSG), total superoxide dismutase (T-SOD), Cu/Zn-SOD, Mn-SOD and glutathione peroxidase (GSH-PX). HLJDD also notably elevated the levels of microtubule-associated protein 1 light chain 3 (LC3), Beclin-1, and other autophagy related genes (Atgs), promoted the activation of extracellular signal-regulated kinases (ERK), protein kinase B (Akt), 3-phosphoinositide-dependent kinase (PDK1), and inhibited the activation of mammalian target of rapamycin (mTOR), c-Jun N-terminal protein kinases (JNK), p38, phosphatase and tensin homolog (PTEN). HLJDD showed neuroprotective effects on ischemic stroke, at least in part to the induced protective autophagy via the regulation of mitogen-activated protein kinase (MAPK) signals. This Akt-independent protective autophagy is favorable in the treatment of stroke, avoiding unfavorable side

  3. DVD-d. Shrek Kolmas; Ma olen legend / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2008-01-01

    Lühiarvustused USA 2007.a. filmidele : animafilm "Shrek Kolmas" ("Shrek the Third", režissöörid Chris Miller, Raman Hui) ja ulmefilm "Ma olen legend" ("I Am Legend"; režissöör Francis Lawrence)

  4. MaRGEE: Move and Rotate Google Earth Elements

    Science.gov (United States)

    Dordevic, Mladen M.; Whitmeyer, Steven J.

    2015-12-01

    Google Earth is recognized as a highly effective visualization tool for geospatial information. However, there remain serious limitations that have hindered its acceptance as a tool for research and education in the geosciences. One significant limitation is the inability to translate or rotate geometrical elements on the Google Earth virtual globe. Here we present a new JavaScript web application to "Move and Rotate Google Earth Elements" (MaRGEE). MaRGEE includes tools to simplify, translate, and rotate elements, add intermediate steps to a transposition, and batch process multiple transpositions. The transposition algorithm uses spherical geometry calculations, such as the haversine formula, to accurately reposition groups of points, paths, and polygons on the Google Earth globe without distortion. Due to the imminent deprecation of the Google Earth API and browser plugin, MaRGEE uses a Google Maps interface to facilitate and illustrate the transpositions. However, the inherent spatial distortions that result from the Google Maps Web Mercator projection are not apparent once the transposed elements are saved as a KML file and opened in Google Earth. Potential applications of the MaRGEE toolkit include tectonic reconstructions, the movements of glaciers or thrust sheets, and time-based animations of other large- and small-scale geologic processes.

  5. The Authority and Charismas of Jack Ma's Leadership

    Institute of Scientific and Technical Information of China (English)

    陈希

    2014-01-01

    Jack Ma is the top manager of Ali Baba group, with a strong leadership. He mixes autocratic leadership and charismatic leadership together. The powers he used are from his position, the reward system of the company and the charismas to gain his leading power. In addition, he uses his charismas and his achievements to win the trust of the employees, which develop his leadership.

  6. Faculty of Law: MaRBLe for Lawyers

    NARCIS (Netherlands)

    Akkermans, Bram; Bastiaens, Ellen; van Tilburg, Jonathan; van Merriënboer, Jeroen

    The Maastricht University Research Based Learning (MaRBLe) project offered a unique but challenging opportunity to the law faculty. Working with undergraduate (or bachelor) students on research was already part of regular, i.e. curricular, teaching activities, but the number of students and

  7. The Launch of the MA-6, Friendship 7

    Science.gov (United States)

    1962-01-01

    The launch of the MA-6, Friendship 7, on February 20, 1962. Boosted by the Mercury-Atlas vehicle, a modified Atlas Intercontinental Ballistic Missile (ICBM), Friendship 7 was the first U.S. marned orbital flight and carried Astronaut John H. Glenn into orbit. Astronaut Glenn became the first American to orbit the Earth.

  8. 78 FR 35756 - Drawbridge Operation Regulations; Charles River, Boston, MA

    Science.gov (United States)

    2013-06-14

    ... Regulations; Charles River, Boston, MA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from...) Bridge across the Charles River, mile 1.0, at Boston, Massachusetts. Under this temporary deviation the... Metropolitan District Commission (Craigie) Bridge, across the Charles River, mile 1.0, at Boston, Massachusetts...

  9. Cosmic Rays Accelerated at Cosmological Shock Waves Renyi Ma1 ...

    Indian Academy of Sciences (India)

    Cosmic Rays Accelerated at Cosmological Shock Waves. Renyi Ma1,2,∗ ... ratio of CR to thermal energy in the ICM and WHIM based on numerical simulations and diffusive shock ... Hence, the nonthermal radiation of CRs may provide us a.

  10. China's Overseas M&A in Global Economic Crisis

    Institute of Scientific and Technical Information of China (English)

    Han Kang

    2009-01-01

    @@ verseas Merger and Acquisition (M&A) is not only the major means for the enterprises to expand rapid-ly and operate globally, but also the significant stra-tegic tools for acquiring advanced technotegy from other companies and seizing the market and other resources.

  11. M&A New Rules May Trigger Merger Wave

    Institute of Scientific and Technical Information of China (English)

    HUBERT TSE

    2006-01-01

    @@ The Chinese government issued a series of new M&A and takeover rules in July and August 2006 to further regulate and facilitate foreign investors' acquisition activities in China.The new rules are aimed at offering more flexibility, reducing costs and increasing takeover efficiencies for foreign-funded M&As in the world's fastest-growing major economy.

  12. Organisational Learning through International M&A Integration Strategies

    Science.gov (United States)

    Holland, Wayne; Salama, Alzira

    2010-01-01

    Purpose: The purpose of this research paper is to explore the learning process associated with international mergers and acquisitions (M&A) integration strategies. Design/methodology/approach: The paper employs a comparative case study methodology, utilising qualitative data through in-depth interviews with top management responsible for…

  13. Ma2 antibodies: an evaluation of commercially available detection methods.

    Science.gov (United States)

    Johannis, Wibke; Renno, Joerg H; Wielckens, Klaus; Voltz, Raymond

    2011-01-01

    Ma2 antibodies belong to the onconeuronal antibodies which define a "definite" paraneoplastic neurological syndrome (PNS). Because of the clinical relevance, use of two separate methods (indirect immunofluorescence technique--IFT--and immunoblot) is advocated; however, with an increasing number of commercially available assay systems, usually only one assay is performed. We compared IFT and three commercially available immunoblots (ravo Diagnostika, Euroimmun, Milenia Biotec) on sera from 35 patients with clinically suspected PNS. 17 were Ma2 antibody associated as defined by consensus result (showing positive reactivity in 2 assays), 18 were Ma2 antibody negative controls. Sensitivity/specificity for single assays were for IFT 94%/94%, for ravo Diagnostika PNS blot 88%/100%, for Euroimmun Neuronal Antigens Profile blot 100%/89%, and for Milenia Biotec MTR blot 94%/100%. Our data confirm, although all tests performed well, a combination of 2 independent assays is still advisable for Ma2 antibody detection in order to achieve higher sensitivity and specificity rates.

  14. 42 CFR 422.74 - Disenrollment by the MA organization.

    Science.gov (United States)

    2010-10-01

    ... providing reasonable accommodations, as determined by CMS, for individuals with mental or cognitive conditions, including mental illness and developmental disabilities. In addition, the MA organization must... timeframes specified in § 422.506(a)(2). (e) Consequences of disenrollment—(1) Disenrollment for non-payment...

  15. PuMA: the Porous Microstructure Analysis software

    Science.gov (United States)

    Ferguson, Joseph C.; Panerai, Francesco; Borner, Arnaud; Mansour, Nagi N.

    2018-01-01

    The Porous Microstructure Analysis (PuMA) software has been developed in order to compute effective material properties and perform material response simulations on digitized microstructures of porous media. PuMA is able to import digital three-dimensional images obtained from X-ray microtomography or to generate artificial microstructures. PuMA also provides a module for interactive 3D visualizations. Version 2.1 includes modules to compute porosity, volume fractions, and surface area. Two finite difference Laplace solvers have been implemented to compute the continuum tortuosity factor, effective thermal conductivity, and effective electrical conductivity. A random method has been developed to compute tortuosity factors from the continuum to rarefied regimes. Representative elementary volume analysis can be performed on each property. The software also includes a time-dependent, particle-based model for the oxidation of fibrous materials. PuMA was developed for Linux operating systems and is available as a NASA software under a US & Foreign release.

  16. Second Generation Dutch Pulsar Machine - PuMa-II

    NARCIS (Netherlands)

    Karuppusamy, Ramesh; Stappers, Ben; Slump, Cornelis H.; van der Klis, Michiel

    2004-01-01

    The Second Generation Pulsar Machine (PuMa- II) is under development for the Westerbork Synthesis Radio Telescope. This is a summary of th e system design and architecture. We show that state of the art pulsar research is possible with commercially available hardware components. This approach

  17. MA-23-6000: underwater bilateral servo master slave manipulator

    International Nuclear Information System (INIS)

    Vertut, Jean

    The different types of manipulators, recent data on their dexterity and the underwater work possible with servo master slave manipulators are reviewed. The general specifications of the manipulator MA 23-6000 designed for the machine ERIC II are given [fr

  18. Predicting Sediment Thickness on Vanished Ocean Crust Since 200 Ma

    Science.gov (United States)

    Dutkiewicz, A.; Müller, R. D.; Wang, X.; O'Callaghan, S.; Cannon, J.; Wright, N. M.

    2017-12-01

    Tracing sedimentation through time on existing and vanished seafloor is imperative for constraining long-term eustasy and for calculating volumes of subducted deep-sea sediments that contribute to global geochemical cycles. We present regression algorithms that incorporate the age of the ocean crust and the mean distance to the nearest passive margin to predict sediment thicknesses and long-term decompacted sedimentation rates since 200 Ma. The mean sediment thickness decreases from ˜220 m at 200 Ma to a minimum of ˜140 m at 130 Ma, reflecting the replacement of old Panthalassic ocean floor with young sediment-poor mid-ocean ridges, followed by an increase to ˜365 m at present-day. This increase reflects the accumulation of sediments on ageing abyssal plains proximal to passive margins, coupled with a decrease in the mean distance of any parcel of ocean crust to the nearest passive margin by over 700 km, and a doubling of the total passive margin length at present-day. Mean long-term sedimentation rates increase from ˜0.5 cm/ky at 160 Ma to over 0.8 cm/ky today, caused by enhanced terrigenous sediment influx along lengthened passive margins, superimposed by the onset of ocean-wide carbonate sedimentation. Our predictive algorithms, coupled to a plate tectonic model, provide a framework for constraining the seafloor sediment-driven eustatic sea-level component, which has grown from ˜80 to 210 m since 120 Ma. This implies a long-term sea-level rise component of 130 m, partly counteracting the contemporaneous increase in ocean basin depth due to progressive crustal ageing.

  19. Tyrosine supplementation for phenylketonuria.

    Science.gov (United States)

    Webster, Diana; Wildgoose, Joanne

    2013-06-05

    Phenylketonuria is an inherited disease for which the main treatment is the dietary restriction of the amino acid phenylalanine. The diet has to be initiated in the neonatal period to prevent or reduce mental handicap. However, the diet is very restrictive and unpalatable and can be difficult to follow. A deficiency of the amino acid tyrosine has been suggested as a cause of some of the neuropsychological problems exhibited in phenylketonuria. Therefore, this review aims to assess the efficacy of tyrosine supplementation for phenylketonuria. To assess the effects of tyrosine supplementation alongside or instead of a phenylalanine-restricted diet for people with phenylketonuria, who commenced on diet at diagnosis and either continued on the diet or relaxed the diet later in life. To assess the evidence that tyrosine supplementation alongside, or instead of a phenylalanine-restricted diet improves intelligence, neuropsychological performance, growth and nutritional status, mortality rate and quality of life. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Trials Register which is comprised of references identified from comprehensive electronic database searches, handsearches of relevant journals and abstract books of conference proceedings. Additional studies were identified from handsearches of the Journal of Inherited Metabolic Disease (from inception in 1978 to 1998). The manufacturers of prescribable dietary products used in the treatment of phenylketonuria were also contacted for further references.Date of the most recent search of the Group's Inborn Errors of Metabolism Trials Register: 28 June 2012. All randomised or quasi-randomised trials investigating the use of tyrosine supplementation versus placebo in people with phenylketonuria in addition to, or instead of, a phenylalanine-restricted diet. People treated for maternal phenylketonuria were excluded. Two authors independently assessed the trial eligibility, methodological quality

  20. The SDSS-IV MaNGA Sample: Design, Optimization, and Usage Considerations

    Science.gov (United States)

    Wake, David A.; Bundy, Kevin; Diamond-Stanic, Aleksandar M.; Yan, Renbin; Blanton, Michael R.; Bershady, Matthew A.; Sánchez-Gallego, José R.; Drory, Niv; Jones, Amy; Kauffmann, Guinevere; Law, David R.; Li, Cheng; MacDonald, Nicholas; Masters, Karen; Thomas, Daniel; Tinker, Jeremy; Weijmans, Anne-Marie; Brownstein, Joel R.

    2017-09-01

    We describe the sample design for the SDSS-IV MaNGA survey and present the final properties of the main samples along with important considerations for using these samples for science. Our target selection criteria were developed while simultaneously optimizing the size distribution of the MaNGA integral field units (IFUs), the IFU allocation strategy, and the target density to produce a survey defined in terms of maximizing signal-to-noise ratio, spatial resolution, and sample size. Our selection strategy makes use of redshift limits that only depend on I-band absolute magnitude (M I ), or, for a small subset of our sample, M I and color (NUV - I). Such a strategy ensures that all galaxies span the same range in angular size irrespective of luminosity and are therefore covered evenly by the adopted range of IFU sizes. We define three samples: the Primary and Secondary samples are selected to have a flat number density with respect to M I and are targeted to have spectroscopic coverage to 1.5 and 2.5 effective radii (R e ), respectively. The Color-Enhanced supplement increases the number of galaxies in the low-density regions of color-magnitude space by extending the redshift limits of the Primary sample in the appropriate color bins. The samples cover the stellar mass range 5× {10}8≤slant {M}* ≤slant 3× {10}11 {M}⊙ {h}-2 and are sampled at median physical resolutions of 1.37 and 2.5 kpc for the Primary and Secondary samples, respectively. We provide weights that will statistically correct for our luminosity and color-dependent selection function and IFU allocation strategy, thus correcting the observed sample to a volume-limited sample.

  1. EDM forum supplement overview.

    Science.gov (United States)

    Calonge, Ned

    2012-07-01

    The Agency for Health Research and Quality funded the Electronic Data Methods Forum (EDM Forum) to share the experiences and learnings from 11 research teams funded through three different grant programs, each of which involve the use of electronic clinical data in Comparative Effectiveness Research and Patient-Centered Outcomes Research. This overview is meant to describe the context in which the EDM forum was created and to introduce the set of papers in this supplement to Medical Care that describe the challenges and approaches to the use of electronic clinical data in the three key areas of analytic methods, clinical informatics and data governance. The participants in the EDM Forum are providing innovative approaches to generate information that can support the building of a "learning health care system." The compilation of papers presented in this supplement should serve as a resource to others working to develop the infrastructure for collecting, validating and using electronic data for research.

  2. Effective Nutritional Supplement Combinations

    Science.gov (United States)

    Cooke, Matt; Cribb, Paul J.

    Few supplement combinations that are marketed to athletes are supported by scientific evidence of their effectiveness. Quite often, under the rigor of scientific investigation, the patented combination fails to provide any greater benefit than a group given the active (generic) ingredient. The focus of this chapter is supplement combinations and dosing strategies that are effective at promoting an acute physiological response that may improve/enhance exercise performance or influence chronic adaptations desired from training. In recent years, there has been a particular focus on two nutritional ergogenic aids—creatine monohydrate and protein/amino acids—in combination with specific nutrients in an effort to augment or add to their already established independent ergogenic effects. These combinations and others are discussed in this chapter.

  3. Clinical analysis of anti-Ma2-associated encephalitis.

    Science.gov (United States)

    Dalmau, Josep; Graus, Francesc; Villarejo, Alberto; Posner, Jerome B; Blumenthal, Deborah; Thiessen, Brian; Saiz, Albert; Meneses, Patricio; Rosenfeld, Myrna R

    2004-08-01

    Increasing experience indicates that anti-Ma2-associated encephalitis differs from classical paraneoplastic limbic or brainstem encephalitis, and therefore may be unrecognized. To facilitate its diagnosis we report a comprehensive clinical analysis of 38 patients with anti-Ma2 encephalitis. Thirty-four (89%) patients presented with isolated or combined limbic, diencephalic or brainstem dysfunction, and four with other syndromes. Considering the clinical and MRI follow-up, 95% of the patients developed limbic, diencephalic or brainstem encephalopathy. Only 26% had classical limbic encephalitis. Excessive daytime sleepiness affected 32% of the patients, sometimes with narcolepsy-cataplexy and low CSF hypocretin. Additional hormonal or MRI abnormalities indicated diencephalic-hypothalamic involvement in 34% of the patients. Eye movement abnormalities were prominent in 92% of the patients with brainstem dysfunction, but those with additional limbic or diencephalic deficits were most affected; 60% of these patients had vertical gaze paresis that sometimes evolved to total external ophthalmoplegia. Three patients developed atypical parkinsonism, and two a severe hypokinetic syndrome with a tendency to eye closure and dramatic reduction of verbal output. Neurological symptoms preceded the tumour diagnosis in 62% of the patients. Brain MRI abnormalities were present in 74% of all patients and 89% of those with limbic or diencephalic dysfunction. Among the 34 patients with cancer, 53% had testicular germ-cell tumours. Two patients without evidence of cancer had testicular microcalcification and one cryptorchidism, risk factors for testicular germ-cell tumours. After neurological syndrome development, 17 of 33 patients received oncological treatment (nine also immunotherapy), 10 immunotherapy alone, and six no treatment. Overall, 33% of the patients had neurological improvement, three with complete recovery; 21% had long-term stabilization, and 46% deteriorated. Features

  4. A comparison of cross-country mountain destination importance performance as perceived by international and domestic tourists: a cast study of Mt. Huang (China and Mt. Seorak (South Korea

    Directory of Open Access Journals (Sweden)

    Renuka Newpaney

    2012-01-01

    Full Text Available In this study, we examine visitor’s importance and destination performance with respect to tourist attractions such as the environment, adventure, social culture, accessibility and relaxation of participants at Mt. Huang and Mt. Seorak respectively. This study identified the demographic characteristics of visitors to both mountain destinations. The researchers used the Importance Performed Analysis (IPA method to identify the importance and satisfaction levels of various attributes of both Mt. Huang and Mt. Seorak. They identified that the most important attributes sought after related to the natural environment, mountaineering, knowledge and information sharing, value of money and escape from a mundane daily job routine, while the least important would relate to mountain sports and the localities' inviting ambience for both mountain destinations. Using a simple questionnaire sample procedure, 247 visitors were considered in order to determine what the visitor’s deemed to be important, and what was satisfying from a destination performance perspective. SPSS 17 was used to analyze the data in different stages and pilot testing was conducted. The finding of this study can be helpful for tourist decision-makers in the public and private sectors. It is also useful to improve tourism services and to develop strategies for greater tourism promotion to the two destinations. Furthermore, this study can be a powerful source of input for destination promotion and positioning activities.

  5. MaGnET: Malaria Genome Exploration Tool.

    Science.gov (United States)

    Sharman, Joanna L; Gerloff, Dietlind L

    2013-09-15

    The Malaria Genome Exploration Tool (MaGnET) is a software tool enabling intuitive 'exploration-style' visualization of functional genomics data relating to the malaria parasite, Plasmodium falciparum. MaGnET provides innovative integrated graphic displays for different datasets, including genomic location of genes, mRNA expression data, protein-protein interactions and more. Any selection of genes to explore made by the user is easily carried over between the different viewers for different datasets, and can be changed interactively at any point (without returning to a search). Free online use (Java Web Start) or download (Java application archive and MySQL database; requires local MySQL installation) at http://malariagenomeexplorer.org joanna.sharman@ed.ac.uk or dgerloff@ffame.org Supplementary data are available at Bioinformatics online.

  6. Experimental Physical Sciences Vistas: MaRIE (draft)

    Energy Technology Data Exchange (ETDEWEB)

    Shlachter, Jack [Los Alamos National Laboratory

    2010-09-08

    To achieve breakthrough scientific discoveries in the 21st century, a convergence and integration of world-leading experimental facilities and capabilities with theory, modeling, and simulation is necessary. In this issue of Experimental Physical Sciences Vistas, I am excited to present our plans for Los Alamos National Laboratory's future flagship experimental facility, MaRIE (Matter-Radiation Interactions in Extremes). MaRIE is a facility that will provide transformational understanding of matter in extreme conditions required to reduce or resolve key weapons performance uncertainties, develop the materials needed for advanced energy systems, and transform our ability to create materials by design. Our unique role in materials science starting with the Manhattan Project has positioned us well to develop a contemporary materials strategy pushing the frontiers of controlled functionality - the design and tailoring of a material for the unique demands of a specific application. Controlled functionality requires improvement in understanding of the structure and properties of materials in order to synthesize and process materials with unique characteristics. In the nuclear weapons program today, improving data and models to increase confidence in the stockpile can take years from concept to new knowledge. Our goal with MaRIE is to accelerate this process by enhancing predictive capability - the ability to compute a priori the observables of an experiment or test and pertinent confidence intervals using verified and validated simulation tools. It is a science-based approach that includes the use of advanced experimental tools, theoretical models, and multi-physics codes, simultaneously dealing with multiple aspects of physical operation of a system that are needed to develop an increasingly mature predictive capability. This same approach is needed to accelerate improvements to other systems such as nuclear reactors. MaRIE will be valuable to many national

  7. Determinants of dietary supplement use - healthy individuals use dietary supplements

    DEFF Research Database (Denmark)

    Kofoed, Christina L F; Christensen, Jane; Dragsted, Lars Ove

    2015-01-01

    influence the use of dietary supplements. Only few studies investigating the use of dietary supplements have been conducted in the Danish population. The present cross-sectional study is based on 54 948 Danes, aged 50-64 years, who completed self-administrated questionnaires on diet, dietary supplements...... and lifestyle between 1993 and 1997. A health index including smoking, physical activity, alcohol and diet, and a metabolic risk index including waist circumference, urinary glucose and measured hypertension were constructed. Logistic regression was used to investigate these determinants in relation...... to the intake of dietary supplements. We found that 71 % of the participants were dietary supplement users; female sex, older age groups and higher educated participants were more likely to be users of any dietary supplements. One additional point in the health index was associated with 19, 16 and 9 % higher...

  8. Entropic derivation of F=ma for circular motion

    International Nuclear Information System (INIS)

    Duncan, Michael; Myrzakulov, Ratbay; Singleton, Douglas

    2011-01-01

    We examine the entropic picture of Newton's second law for the case of circular motion. It is shown that one must make modifications to the derivation of F=ma due to a change in the effective Unruh temperature for circular motion. These modifications present a challenge to the entropic derivation of Newton's second law, but also open up the possibility to experimentally test and constrain this model for large centripetal accelerations.

  9. A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome

    Directory of Open Access Journals (Sweden)

    Huang JY

    2016-05-01

    Full Text Available Jehn-Yu Huang, Po-Ting Yeh, Yu-Chih Hou Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan Purpose: To evaluate the efficacy of oral antioxidant supplementation in the treatment of patients with dry eye syndrome (DES. Methods: A prospective, randomized, double-blinded study compared the effects of an antioxidant supplement (containing anthocyanosides, astaxanthin, vitamins A, C, and E, and several herbal extracts, including Cassiae semen and Ophiopogonis japonicus with placebo on patients with DES. We assessed dry eye symptoms, visual acuity, Schirmer’s test, tear film breakup time, cornea and conjunctiva fluorescein staining, serum anti-SSA/anti-SSB antibodies, and the level of reactive oxygen species (ROS in tears. The supplementation period was 8 weeks and patients were followed up every 4 weeks for 16 weeks. A linear mixed model was used to compare the groups, while within-group differences were tested by repeated-measures analysis of variance. Results: Forty-three patients, 20 and 23 in treatment and placebo groups, respectively, completed the study. Liver and renal functions were normal. Diastolic blood pressure decreased in the treatment group. There were no significant differences in systolic blood pressure, dry eye symptoms, serum anti-SSA and anti-SSB, visual acuity, intraocular pressure, or fluorescein corneal staining between the groups. Tear film breakup time scores and Schirmer’s test without topical anesthesia significantly improved in the treatment group. Tear ROS level differed between the groups and decreased after treatment. Overall subjective impression revealed a significant improvement with treatment compared with placebo. Conclusion: Oral antioxidant supplementations may increase tear production and improve tear film stability by reducing tear ROS. The vegetable-based antioxidant supplement used in this study is safe and can be utilized as

  10. SCHeMA web-based observation data information system

    Science.gov (United States)

    Novellino, Antonio; Benedetti, Giacomo; D'Angelo, Paolo; Confalonieri, Fabio; Massa, Francesco; Povero, Paolo; Tercier-Waeber, Marie-Louise

    2016-04-01

    It is well recognized that the need of sharing ocean data among non-specialized users is constantly increasing. Initiatives that are built upon international standards will contribute to simplify data processing and dissemination, improve user-accessibility also through web browsers, facilitate the sharing of information across the integrated network of ocean observing systems; and ultimately provide a better understanding of the ocean functioning. The SCHeMA (Integrated in Situ Chemical MApping probe) Project is developing an open and modular sensing solution for autonomous in situ high resolution mapping of a wide range of anthropogenic and natural chemical compounds coupled to master bio-physicochemical parameters (www.schema-ocean.eu). The SCHeMA web system is designed to ensure user-friendly data discovery, access and download as well as interoperability with other projects through a dedicated interface that implements the Global Earth Observation System of Systems - Common Infrastructure (GCI) recommendations and the international Open Geospatial Consortium - Sensor Web Enablement (OGC-SWE) standards. This approach will insure data accessibility in compliance with major European Directives and recommendations. Being modular, the system allows the plug-and-play of commercially available probes as well as new sensor probess under development within the project. The access to the network of monitoring probes is provided via a web-based system interface that, being implemented as a SOS (Sensor Observation Service), is providing standard interoperability and access tosensor observations systems through O&M standard - as well as sensor descriptions - encoded in Sensor Model Language (SensorML). The use of common vocabularies in all metadatabases and data formats, to describe data in an already harmonized and common standard is a prerequisite towards consistency and interoperability. Therefore, the SCHeMA SOS has adopted the SeaVox common vocabularies populated by

  11. Narcolepsy, REM sleep behavior disorder, and supranuclear gaze palsy associated with Ma1 and Ma2 antibodies and tonsillar carcinoma.

    Science.gov (United States)

    Adams, Chris; McKeon, Andrew; Silber, Michael H; Kumar, Rajeev

    2011-04-01

    To describe a patient with diencephalic and mesencephalic presentation of a Ma1 and Ma2 antibody-associated paraneoplastic neurological disorder. Case report. The Colorado Neurological Institute Movement Disorders Center in Englewood, Colorado, and the Mayo Clinic in Rochester, Minnesota. A 55-year-old man with a paraneoplastic neurological disorder characterized by rapid eye movement sleep behavior disorder, narcolepsy, and a progressive supranuclear palsy-like syndrome in the setting of tonsillar carcinoma. Immunotherapy for paraneoplastic neurological disorder, surgery and radiotherapy for cancer, and symptomatic treatment for parkinsonism and sleep disorders. Polysomnography, multiple sleep latency test, and neurological examination. The cancer was detected at a limited stage and treatable. After oncological therapy and immunotherapy, symptoms stabilized. Treatment with modafinil improved daytime somnolence. Rapid onset and progression of multifocal deficits may be a clue to paraneoplastic etiology. Early treatment of a limited stage cancer (with or without immunotherapy) may possibly slow progression of neurological symptoms. Symptomatic treatment may be beneficial.

  12. The Banana Fruit SINA Ubiquitin Ligase MaSINA1 Regulates the Stability of MaICE1 to be Negatively Involved in Cold Stress Response.

    Science.gov (United States)

    Fan, Zhong-Qi; Chen, Jian-Ye; Kuang, Jian-Fei; Lu, Wang-Jin; Shan, Wei

    2017-01-01

    The regulation of ICE1 protein stability is important to ensure effective cold stress response, and is extensively studied in Arabidopsis . Currently, how ICE1 stability in fruits under cold stress is controlled remains largely unknown. Here, we reported the possible involvement of a SEVEN IN ABSENTIA (SINA) ubiquitin ligase MaSINA1 from banana fruit in affecting MaICE1 stability. MaSINA1 was identified based on a yeast two-hybrid screening using MaICE1 as bait. Further yeast two-hybrid, pull-down, bimolecular fluorescence complementation (BiFC) and co-immunoprecipitation (CoIP) assays confirmed that MaSINA1 interacted with MaICE1. The expression of MaSINA1 was repressed by cold stress. Subcellular localization analysis in tobacco leaves showed that MaSINA1 was localized predominantly in the nucleus. In vitro ubiquitination assay showed that MaSINA1 possessed E3 ubiquitin ligase activity. More importantly, in vitro and semi- in vivo experiments indicated that MaSINA1 can ubiquitinate MaICE1 for the 26S proteasome-dependent degradation, and therefore suppressed the transcriptional activation of MaICE1 to MaNAC1, an important regulator of cold stress response of banana fruit. Collectively, our data reveal a mechanism in banana fruit for control of the stability of ICE1 and for the negative regulation of cold stress response by a SINA E3 ligase via the ubiquitin proteasome system.

  13. ImpersoNations: cinéma national, imaginaires historiques et nouveau cinéma européen

    NARCIS (Netherlands)

    Elsaesser, T.

    2013-01-01

    La question du capital culturel propre à la diversité linguistique de l’Europe reste entière. Quels sont les avantages et les inconvénients de cet éventail de langues dans le cinéma? Les films, quand ils franchissent les frontières, sont souvent doublés. Or, comme un bon jeu d’acteur représente une

  14. MICROBIOLOGICAL QUALITY OF FOOD SUPPLEMENTS.

    Science.gov (United States)

    Ratajczak, Magdalena; Kubicka, Marcelina M; Kamińska, Dorota; Długaszewska, Jolanta

    2015-01-01

    Many specialists note that the food offered today - as a result of very complex technological processing - is devoid of many components that are important for the organism and the shortages have to be supplemented. The simplest for it is to consume diet supplements that provide the missing element in a concentrated form. In accordance with the applicable law, medicinal products include all substances or mixtures of substances that are attributed with properties of preventing or treating diseases with humans or animals. Permits to admit supplements to the market are issued by the Chief Sanitary Inspector and the related authorities; permits for medicines are issued by the Chief Pharmaceutical Inspector and the Office for Registration of Medicinal Products, Medical Devices and Biocidal Products. Therefore, admittance of a supplement to the market is less costly and time consuming_than admittance of a medicine. Supplements and medicines may contain the same component but medicines will have a larger concentration than supplements. Sale of supplements at drug stores and in the form of tablets, capsules, liquids or powders makes consumer often confusing supplements with medicines. Now there are no normative documents specifying limits of microbiological impurities in diet supplements. In Polish legislation, diet supplements are subject to legal acts concerning food. Medicines have to comply with microbiological purity requirements specified in the Polish Pharmacopeia. As evidenced with the completed tests, the proportion of diet supplement samples with microbiological impurities is 6.5%. Sales of diet supplements have been growing each year, they are consumed by healthy people but also people with immunology deficiencies and by children and therefore consumers must be certain that they buy safe products.

  15. Issues in Nutrition: Dietary Supplements.

    Science.gov (United States)

    Thompson, Margaret E; Noel, Mary Barth

    2017-01-01

    The majority of American adults report use of one or more dietary supplements every day or occasionally. The Dietary Supplement Health and Education Act of 1994 defines dietary supplements and regulates their manufacture and distribution. One of the most commonly used supplements is vitamin D. Measurement of serum levels of vitamin D must be undertaken with the caveats that different laboratories define normal levels differently, and that there is rarely a clinical correlation with the actual level. Patients should understand that supplements should not be used to excess, as there are toxicities and other adverse effects associated with most of them. There currently is considerable research being performed on probiotics and how the gut microbiome affects health and disease states. Protein supplements may be useful in reducing mortality rates in elderly patients but they do not appear to increase quality of life. If used, protein supplements should contain essential amino acids. Casein and whey supplements, derived from dairy sources, help transport essential amino acids to tissues. Although there have been many studies investigating the role of vitamin supplements in disease prevention, there have been few conclusive positive results. Written permission from the American Academy of Family Physicians is required for reproduction of this material in whole or in part in any form or medium.

  16. Lead in calcium supplements (abstract)

    International Nuclear Information System (INIS)

    Rehman, S.; Khalid, N.

    2011-01-01

    Lead present in calcium supplements is of grave concern as some lead levels have been measured up to the extent of regulatory limit set by the United States. Calcium supplements inevitably get contaminated with lead as both are naturally occurring elements. Therefore, it is imperative to indicate its level in these supplements in order to create awareness among consumers. In this study, a sophisticated analytical technique, atomic absorption spectrometry was used to analyze Pb contents in 27 commonly consumed Ca supplements manufactured by different national and multinational companies. The daily intake of lead through these supplements was calculated. Only 10% of the calcium supplements analyzed met the criteria of acceptable Pb levels (1.5 mu g/daily dose) in supplements/consumer products set by the United States. It was also found that Pb intake was highest in chelated calcium supplements 28.5 mu g/daily dose, whereas lowest 0.47 mu g/daily dose through calcium supplements with vitamin D formulation. In order to validate our results from the study conducted, IAEA-certified reference material (animal bone, H-5) was analyzed for its Pb levels. The levels of Pb determined were quite in good agreement with the certified values. (author)

  17. Bodybuilding supplementation and tooth decay.

    Science.gov (United States)

    Ali, M S; Batley, H; Ahmed, F

    2015-07-10

    Supplementation is a key component in bodybuilding and is increasingly being used by amateur weight lifters and enthusiasts to build their ideal bodies. Bodybuilding supplements are advertised to provide nutrients needed to help optimise muscle building but they can contain high amounts of sugar. Supplement users are consuming these products, while not being aware of their high sugar content, putting them at a higher risk of developing dental caries. It is important for dental professionals to recognise the increased risk for supplement users and to raise awareness, provide appropriate preventative advice and be knowledgeable of alternative products to help bodybuilders reach their goals, without increasing the risk of dental caries.

  18. Enlarged Liver

    Science.gov (United States)

    ... of liver damage. Medicinal herbs. Certain herbs, including comfrey, ma huang and mistletoe, can increase your risk ... herbs to avoid include germander, chaparral, senna, mistletoe, comfrey, ma huang, valerian root, kava, celandine and green ...

  19. Botanical supplements: detecting the transition from ingredients to supplements

    Science.gov (United States)

    Methods were developed using flow injection mass spectrometry (FIMS) and chemometrics for the comparison of spectral similarities and differences of 3 botanical ingredients and their supplements: Echinacea purpurea aerial samples and solid and liquid supplements, E. purpurea root samples and solid s...

  20. SDSS-IV/MaNGA: SPECTROPHOTOMETRIC CALIBRATION TECHNIQUE

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Renbin; Sánchez-Gallego, José R. [Department of Physics and Astronomy, University of Kentucky, 505 Rose St., Lexington, KY 40506-0057 (United States); Tremonti, Christy; Bershady, Matthew A.; Eigenbrot, Arthur; Wake, David A. [Department of Astronomy, University of Winsconsin-Madison, 475 N. Charter Street, Madison, WI 53706-1582 (United States); Law, David R. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Schlegel, David J. [Physics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720-8160 (United States); Bundy, Kevin [Kavli IPMU (WPI), UTIAS, The University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Drory, Niv [McDonald Observatory, Department of Astronomy, University of Texas at Austin, 1 University Station, Austin, TX 78712-0259 (United States); MacDonald, Nicholas [Department of Astronomy, Box 351580, University of Washington, Seattle, WA 98195 (United States); Bizyaev, Dmitry [Apache Point Observatory, P.O. Box 59, sunspot, NM 88349 (United States); Blanc, Guillermo A. [Departamento de Astronomía, Universidad de Chile, Camino el Observatorio 1515, Las Condes, Santiago (Chile); Blanton, Michael R.; Hogg, David W. [Center for Cosmology and Particle Physics, Department of Physics, New York University, 4 Washington Place, New York, NY 10003 (United States); Cherinka, Brian [Dunlap Institute for Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, Ontario M5S 3H4 (Canada); Gunn, James E. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Harding, Paul [Department of Astronomy, Case Western Reserve University, Cleveland, OH 44106 (United States); Sánchez, Sebastian F., E-mail: yanrenbin@uky.edu [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, A.P. 70-264, 04510 Mexico D.F. (Mexico); and others

    2016-01-15

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA), one of three core programs in the Sloan Digital Sky Survey-IV, is an integral-field spectroscopic survey of roughly 10,000 nearby galaxies. It employs dithered observations using 17 hexagonal bundles of 2″ fibers to obtain resolved spectroscopy over a wide wavelength range of 3600–10300 Å. To map the internal variations within each galaxy, we need to perform accurate spectral surface photometry, which is to calibrate the specific intensity at every spatial location sampled by each individual aperture element of the integral field unit. The calibration must correct only for the flux loss due to atmospheric throughput and the instrument response, but not for losses due to the finite geometry of the fiber aperture. This requires the use of standard star measurements to strictly separate these two flux loss factors (throughput versus geometry), a difficult challenge with standard single-fiber spectroscopy techniques due to various practical limitations. Therefore, we developed a technique for spectral surface photometry using multiple small fiber-bundles targeting standard stars simultaneously with galaxy observations. We discuss the principles of our approach and how they compare to previous efforts, and we demonstrate the precision and accuracy achieved. MaNGA's relative calibration between the wavelengths of Hα and Hβ has an rms of 1.7%, while that between [N ii] λ6583 and [O ii] λ3727 has an rms of 4.7%. Using extinction-corrected star formation rates and gas-phase metallicities as an illustration, this level of precision guarantees that flux calibration errors will be sub-dominant when estimating these quantities. The absolute calibration is better than 5% for more than 89% of MaNGA's wavelength range.

  1. SDSS-IV/MaNGA: SPECTROPHOTOMETRIC CALIBRATION TECHNIQUE

    International Nuclear Information System (INIS)

    Yan, Renbin; Sánchez-Gallego, José R.; Tremonti, Christy; Bershady, Matthew A.; Eigenbrot, Arthur; Wake, David A.; Law, David R.; Schlegel, David J.; Bundy, Kevin; Drory, Niv; MacDonald, Nicholas; Bizyaev, Dmitry; Blanc, Guillermo A.; Blanton, Michael R.; Hogg, David W.; Cherinka, Brian; Gunn, James E.; Harding, Paul; Sánchez, Sebastian F.

    2016-01-01

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA), one of three core programs in the Sloan Digital Sky Survey-IV, is an integral-field spectroscopic survey of roughly 10,000 nearby galaxies. It employs dithered observations using 17 hexagonal bundles of 2″ fibers to obtain resolved spectroscopy over a wide wavelength range of 3600–10300 Å. To map the internal variations within each galaxy, we need to perform accurate spectral surface photometry, which is to calibrate the specific intensity at every spatial location sampled by each individual aperture element of the integral field unit. The calibration must correct only for the flux loss due to atmospheric throughput and the instrument response, but not for losses due to the finite geometry of the fiber aperture. This requires the use of standard star measurements to strictly separate these two flux loss factors (throughput versus geometry), a difficult challenge with standard single-fiber spectroscopy techniques due to various practical limitations. Therefore, we developed a technique for spectral surface photometry using multiple small fiber-bundles targeting standard stars simultaneously with galaxy observations. We discuss the principles of our approach and how they compare to previous efforts, and we demonstrate the precision and accuracy achieved. MaNGA's relative calibration between the wavelengths of Hα and Hβ has an rms of 1.7%, while that between [N ii] λ6583 and [O ii] λ3727 has an rms of 4.7%. Using extinction-corrected star formation rates and gas-phase metallicities as an illustration, this level of precision guarantees that flux calibration errors will be sub-dominant when estimating these quantities. The absolute calibration is better than 5% for more than 89% of MaNGA's wavelength range

  2. Isolation of MA-ACS Gene Family and Expression Study of MA-ACS1 Gene in Musa acuminata Cultivar Pisang Ambon Lumut

    Directory of Open Access Journals (Sweden)

    LISTYA UTAMI KARMAWAN

    2009-03-01

    Full Text Available Musa acuminata cultivar pisang ambon lumut is a native climacteric fruit from Indonesia. Climacteric fruit ripening process is triggered by the gaseous plant hormone ethylene. The rate limiting enzyme involved in ethylene biosynthesis is ACC synthase (ACS which is encoded by ACS gene family. The objective of this study is to identify MA-ACS gene family in M. acuminata cultivar pisang ambon lumut and to study the MA-ACS1 gene expression. The result showed that there were nine M. acuminata ACS gene family members called MA-ACS1–9. Two of them (MA-ACS1 and MA-ACS2 were assessed using reverse transcriptase PCR (RT-PCR for gene expression study and it was only MA-ACS1 correlated with fruit ripening. The MA-ACS1 gene fragment has been successfully isolated and characterized and it has three introns, four exons, and one stop codon. It also shows highest homology with MACS1 gene from M. acuminata cultivar Hsian Jien Chiao (GenBank accession number AF056164. Expression analysis of MA-ACS1 using quantitative PCR (qPCR showed that MA-ACS1 gene expression increased significantly in the third day, reached maximum at the fifth day, and then decreased in the seventh day after harvesting. The qPCR expression analysis result correlated with the result of physical analysis during fruit ripening.

  3. Cell cycle-dependent SUMO-1 conjugation to nuclear mitotic apparatus protein (NuMA)

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Jae Sung; Kim, Ha Na; Kim, Sun-Jick; Bang, Jiyoung; Kim, Eun-A; Sung, Ki Sa [Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746 (Korea, Republic of); Yoon, Hyun-Joo [TissueGene Inc. 9605 Medical Center Dr., Rockville, MD 20850 (United States); Yoo, Hae Yong [Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Samsung Medical Center, Sungkyunkwan University, Seoul 135-710 (Korea, Republic of); Choi, Cheol Yong, E-mail: choicy@skku.ac.kr [Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746 (Korea, Republic of)

    2014-01-03

    Highlights: •NuMA is modified by SUMO-1 in a cell cycle-dependent manner. •NuMA lysine 1766 is the primary target site for SUMOylation. •SUMOylation-deficient NuMA induces multiple spindle poles during mitosis. •SUMOylated NuMA induces microtubule bundling. -- Abstract: Covalent conjugation of proteins with small ubiquitin-like modifier 1 (SUMO-1) plays a critical role in a variety of cellular functions including cell cycle control, replication, and transcriptional regulation. Nuclear mitotic apparatus protein (NuMA) localizes to spindle poles during mitosis, and is an essential component in the formation and maintenance of mitotic spindle poles. Here we show that NuMA is a target for covalent conjugation to SUMO-1. We find that the lysine 1766 residue is the primary NuMA acceptor site for SUMO-1 conjugation. Interestingly, SUMO modification of endogenous NuMA occurs at the entry into mitosis and this modification is reversed after exiting from mitosis. Knockdown of Ubc9 or forced expression of SENP1 results in impairment of the localization of NuMA to mitotic spindle poles during mitosis. The SUMOylation-deficient NuMA mutant is defective in microtubule bundling, and multiple spindles are induced during mitosis. The mitosis-dependent dynamic SUMO-1 modification of NuMA might contribute to NuMA-mediated formation and maintenance of mitotic spindle poles during mitosis.

  4. 46 CFR 308.306 - Second Seamen's War Risk Policy, Form MA-242.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Second Seamen's War Risk Policy, Form MA-242. 308.306... RISK INSURANCE Second Seamen's War Risk Insurance § 308.306 Second Seamen's War Risk Policy, Form MA-242. (a) The standard form of Second Seamen's War Risk Policy Form MA-242, may be obtained from the...

  5. 46 CFR 308.545 - Facultative cargo policy, Form MA-316.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Facultative cargo policy, Form MA-316. 308.545 Section 308.545 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK... policy, Form MA-316. The standard form of War Risk Facultative Cargo Policy, Form MA-316, may be obtained...

  6. Study of the oxidation kinetics of the MA 956 superalloy

    International Nuclear Information System (INIS)

    Garcia-Alonso, M.C.; Gonzalez-Carrasco, J.L.; Escudero, M.L.

    1998-01-01

    This work deals with the oxidation kinetics of the MA 956 superalloy in the temperature range of 800-1,200 degree centigree for up to 200 h exposure. During oxidation the alloy develops a fine, compact and very well adhered α-alumina layer, the thickness of which increases with increasing time and temperature. The oxidation kinetics obeys a sub parabolic type behaviour. The scale growth seems to occur by two different oxidation mechanisms; above 1,050 degree centigree, the oxidation process would be controlled by α-alumina, and below 900 degree centigree by γ-alumina. (Author) 17 refs

  7. Advanced Query and Data Mining Capabilities for MaROS

    Science.gov (United States)

    Wang, Paul; Wallick, Michael N.; Allard, Daniel A.; Gladden, Roy E.; Hy, Franklin H.

    2013-01-01

    The Mars Relay Operational Service (MaROS) comprises a number of tools to coordinate, plan, and visualize various aspects of the Mars Relay network. These levels include a Web-based user interface, a back-end "ReSTlet" built in Java, and databases that store the data as it is received from the network. As part of MaROS, the innovators have developed and implemented a feature set that operates on several levels of the software architecture. This new feature is an advanced querying capability through either the Web-based user interface, or through a back-end REST interface to access all of the data gathered from the network. This software is not meant to replace the REST interface, but to augment and expand the range of available data. The current REST interface provides specific data that is used by the MaROS Web application to display and visualize the information; however, the returned information from the REST interface has typically been pre-processed to return only a subset of the entire information within the repository, particularly only the information that is of interest to the GUI (graphical user interface). The new, advanced query and data mining capabilities allow users to retrieve the raw data and/or to perform their own data processing. The query language used to access the repository is a restricted subset of the structured query language (SQL) that can be built safely from the Web user interface, or entered as freeform SQL by a user. The results are returned in a CSV (Comma Separated Values) format for easy exporting to third party tools and applications that can be used for data mining or user-defined visualization and interpretation. This is the first time that a service is capable of providing access to all cross-project relay data from a single Web resource. Because MaROS contains the data for a variety of missions from the Mars network, which span both NASA and ESA, the software also establishes an access control list (ACL) on each data record

  8. MaNIDA: an operational infrastructure for shipborne data

    Science.gov (United States)

    Macario, Ana; Scientific MaNIDA Team

    2013-04-01

    The Marine Network for Integrated Data Access (MaNIDA) aims to build a sustainable e-Infrastruture to support discovery and re-use of data archived in a distributed network of data providers in Germany (see related abstracts in session ESSI1.2 and session ESSI2.2). Because one of the primary focus of MaNIDA is the underway data acquired on board of German academic research vessels, we will be addressing various issues related to cruise-level metadata, shiptrack navigation, sampling events conducted during the cruise (event logs), standardization of device-related (type, name, parameters) and place-related (gazetteer) vocabularies, QA/QC procedures (near real time and post-cruise validation, corrections, quality flags) as well as ingestion and management of contextual information (e.g. various types of cruise-related reports and project-related information). One of MaNIDA's long-term goal is to be able to offer an integrative "one-stop-shop" framework for management and access of ship-related information based on international standards and interoperability. This access framework will be freely available and is intended for scientists, funding agencies and the public. The master "catalog" we are building currently contains information from 13 German academic research vessels and respective cruises (to date ~1900 cruises with expected growing rate of ~150 cruises annually). Moreover, MaNIDA's operational infrastructure will additionally provide a direct pipeline to SeaDataNet Cruise Summary Report Inventory, among others. In this presentation, we will focus on the extensions we are currently implementing to support automated acquisition and standardized transfer of various types of data from German research vessels to hosts on land. Our concept towards nationwide common QA/QC procedures for various types of underway data (including versioning concept) and common workflows will also be presented. The "linking" of cruise-related information with quality-controlled data

  9. Protection, transfer, and maintenance of the MA23 bilateral servomanipulator

    International Nuclear Information System (INIS)

    Vertut, J.; Marchal, P.; Germond, J.C.; Francois, D.; Brossard, J.P.

    1978-01-01

    After a successful plasma torch cutting test, use of the MA23 in a large cell for maintenance in the new reprocessing plant is anticipated. A protective self-ventilated caisson with a boot is used. The arm is transferred into a decontamination-shielded box, then into a repair glove box. The caisson is repaired in a similar parallel line that has two connecting repair boxes. The recent two-operator glove-box recabling test showed the feasibility of this concept. Total labor was twice that of factory cabling labor. Arm improvement and tooling are being designed. A full, double-maintenance line mockup will be tested in mid-1979

  10. Sceny kulturowe a polityki kultury w Małopolsce

    OpenAIRE

    Kowalik, Wojciech; Krzyżowski, Łukasz; Noworól, Zofia; Knaś, Piotr

    2010-01-01

    Książka zawiera diagnozę kultury w oparciu o pogłębioną analizę scen kultury w 10 gminach Małopolski. Wskazano w nim zależności pomiędzy działaniami kulturowymi podejmowanymi przez lokalnych aktorów kultury (instytucje kultury, III sektor, inicjatywy indywidualne, sektor przemysłów kultury) a lokalną polityką kulturową (przede wszystkim w kwestii roli samorządu lokalnego). Ministerstwo Kultury i Dziedzictwa Narodowego Wojciech Kowalik

  11. Food Components and Supplements

    DEFF Research Database (Denmark)

    Parlesak, Alexandr

    2012-01-01

    The major part of food consists of chemical compounds that can be used for energy production, biological synthesis, or maintenance of metabolic processes by the host. These components are defined as nutrients, and can be categorized into macronutrients (proteins, carbohydrates, triglycerides......, and alcohol), minerals, and micronutrients. The latter category comprises 13 vitamins and a hand full of trace elements. Many micronutrients are used as food supplements and are ingested at doses exceeding the amounts that can be consumed along with food by a factor of 10–100. Both macro- and micronutrients...... can interact with enzyme systems related to xenobiotic metabolism either by regulation of their expression or direct interference with their enzymatic activity. During food consumption, we consume a wide range of xenobiotics along with the consumable food, either as an original part of the food (e...

  12. Food Components and Supplements

    DEFF Research Database (Denmark)

    Parlesak, Alexandr

    2012-01-01

    acting as carcinogens) to health-protective effects (e.g., flavonoids ameliorating detrimental effects of mitochondrial oxidative stress). In particular, secondary plant metabolites along with vitamins, specific types of macronutrients and live bacteria (probiotics) as well as substances promoting.......g., secondary plant metabolites such as flavonoids), or as contaminants that enter the food chain at different stages or during the food production process. For these components, a wide spectrum of biological effects was observed that ranges from health-threatening impacts (e.g., polycyclic aromatic amines....... The supplements and contaminants can compete directly with drug oxidation, induce or suppress the expression of xenobiotic-metabolizing enzymes, change the bioavailability of drugs, and, in the case of live bacteria, bring in their own xenobiotic metabolism, including cytochrome P450 (CYP) activity. In numerous...

  13. Nutritional Supplements for Endurance Athletes

    Science.gov (United States)

    Rasmussen, Christopher J.

    Athletes engaged in heavy endurance training often seek additional nutritional strategies to help maximize performance. Specific nutritional supplements exist to combat certain factors that limit performance beginning with a sound everyday diet. Research has further demonstrated that safe, effective, legal supplements are in fact available for today's endurance athletes. Several of these supplements are marketed not only to aid performance but also to combat the immunosuppressive effects of intense endurance training. It is imperative for each athlete to research the legality of certain supplements for their specific sport or event. Once the legality has been established, it is often up to each individual athlete to decipher the ethics involved with ingesting nutritional supplements with the sole intent of improving performance.

  14. Regional Assessment of Supplementation Project

    International Nuclear Information System (INIS)

    1991-10-01

    The Fish and Wildlife Program of the Northwest Power Planning Council (NPPC) prescribes several approaches to achieve its goal of doubling the salmon and steelhead runs of the Columbia River. Among those approaches are habitat restoration, improvements in adult and juvenile passage at dams and artificial propagation. Supplementation will be a major part of the new hatchery programs. The purpose of the Regional Assessment of Supplementation Project (RASP) is to provide an overview of ongoing and planned supplementation activities, to construct a conceptual framework and model for evaluating the potential benefits and risks of supplementation and to develop a plan for better regional coordination of research and monitoring and evaluation of supplementation. RASP has completed its first year of work. Progress toward meeting the first year's objectives and recommendations for future tasks are contained in this report

  15. [Features of Professor Ma Kun's medication in treating ovulatory infertility].

    Science.gov (United States)

    Tong, Ya-Jing; Zhang, Hui-Xian; Chen, Yan-Xia; Dong, Mei-Ling; Ma, Kun

    2017-12-01

    In order to analyze Professor Ma Kun's medication in treating anovulatory infertility, her prescriptions for treating anovulatory infertility in 2012-2015 were collected. The medication features and the regularity of prescriptions were mined by using traditional Chinese medicine inheritance support system, association rules, complex system entropy clustering and other mining methods. Finally, a total of 684 prescriptions and 300 kinds of herbs were screened out, with a total frequency of 11 156 times; And 68 core combinations and 8 new prescriptions were mined. The top three frequently used herbs by effect were respectively tonic herb, blood circulation promoting herb, and Qi-circulation promoting herb. The top three tastes were sweetness, bitterness and pungent flavor. The results showed 28 herbs with a high frequency of ≥100.The top 10 frequently used herbs were respectively Angelica Sinensis Radix, Cyperi Rhizoma, Chuanxiong Rhizome, Paeoniae Radix Rubra, Cyathulae Radix, Taxilli Herba, Cuscutae Semen, Codonopsis Radix, Ligustri Lucidi Fructus, Paeoniae Albaand Paeoniae Radix Alba. The association rules analysis showed commonly used herbal pairs, including Rehmanniae Radix Preparata-Chuanxiong Rhizome, Rehmanniae Radix Preparata-Angelica Sinensis Radix, Cuscutae Semen-Dipsaci Radix. In conclusion, Professor Ma has treated anovulatory infertility by nourishing the kidney and activating blood throughout the treatment course, and attached the importance to the relationship between Qi and blood and there gulation of liver, spleen and kidney in treating anovulatory infertility. Copyright© by the Chinese Pharmaceutical Association.

  16. MoMaS reactive transport benchmark using PFLOTRAN

    Science.gov (United States)

    Park, H.

    2017-12-01

    MoMaS benchmark was developed to enhance numerical simulation capability for reactive transport modeling in porous media. The benchmark was published in late September of 2009; it is not taken from a real chemical system, but realistic and numerically challenging tests. PFLOTRAN is a state-of-art massively parallel subsurface flow and reactive transport code that is being used in multiple nuclear waste repository projects at Sandia National Laboratories including Waste Isolation Pilot Plant and Used Fuel Disposition. MoMaS benchmark has three independent tests with easy, medium, and hard chemical complexity. This paper demonstrates how PFLOTRAN is applied to this benchmark exercise and shows results of the easy benchmark test case which includes mixing of aqueous components and surface complexation. Surface complexations consist of monodentate and bidentate reactions which introduces difficulty in defining selectivity coefficient if the reaction applies to a bulk reference volume. The selectivity coefficient becomes porosity dependent for bidentate reaction in heterogeneous porous media. The benchmark is solved by PFLOTRAN with minimal modification to address the issue and unit conversions were made properly to suit PFLOTRAN.

  17. MaROS Strategic Relay Planning and Coordination Interfaces

    Science.gov (United States)

    Allard, Daniel A.

    2010-01-01

    The Mars Relay Operations Service (MaROS) is designed to provide planning and analysis tools in support of ongoing Mars Network relay operations. Strategic relay planning requires coordination between lander and orbiter mission ground data system (GDS) teams to schedule and execute relay communications passes. MaROS centralizes this process, correlating all data relevant to relay coordination to provide a cohesive picture of the relay state. Service users interact with the system through thin-layer command line and web user interface client applications. Users provide and utilize data such as lander view periods of orbiters, Deep Space Network (DSN) antenna tracks, and reports of relay pass performance. Users upload and download relevant relay data via formally defined and documented file structures including some described in Extensible Markup Language (XML). Clients interface with the system via an http-based Representational State Transfer (ReST) pattern using Javascript Object Notation (JSON) formats. This paper will provide a general overview of the service architecture and detail the software interfaces and considerations for interface design.

  18. Milk Oligosaccharides Inhibit Human Rotavirus Infectivity in MA104 Cells.

    Science.gov (United States)

    Laucirica, Daniel R; Triantis, Vassilis; Schoemaker, Ruud; Estes, Mary K; Ramani, Sasirekha

    2017-09-01

    Background: Oligosaccharides in milk act as soluble decoy receptors and prevent pathogen adhesion to the infant gut. Milk oligosaccharides reduce infectivity of a porcine rotavirus strain; however, the effects on human rotaviruses are less well understood. Objective: In this study, we determined the effect of specific and abundant milk oligosaccharides on the infectivity of 2 globally dominant human rotavirus strains. Methods: Four milk oligosaccharides-2'-fucosyllactose (2'FL), 3'-sialyllactose (3'SL), 6'-sialyllactose (6'SL), and galacto-oligosaccharides-were tested for their effects on the infectivity of human rotaviruses G1P[8] and G2P[4] through fluorescent focus assays on African green monkey kidney epithelial cells (MA104 cells). Oligosaccharides were added at different time points in the infectivity assays. Infections in the absence of oligosaccharides served as controls. Results: When compared with infections in the absence of glycans, all oligosaccharides substantially reduced the infectivity of both human rotavirus strains in vitro; however, virus strain-specific differences in effects were observed. Compared with control infections, the maximum reduction in G1P[8] infectivity was seen with 2'FL when added after the onset of infection (62% reduction, P rotaviruses in MA104 cells, primarily through an effect on the virus. Although breastfed infants are directly protected, the addition of specific oligosaccharides to infant formula may confer these benefits to formula-fed infants. © 2017 American Society for Nutrition.

  19. Dietary Supplements: What You Need to Know

    Science.gov (United States)

    ... Food Home Food Resources for You Consumers Dietary Supplements: What You Need to Know Share Tweet Linkedin ... and nutrients you personally need. What are dietary supplements? Dietary supplements include such ingredients as vitamins, minerals, ...

  20. Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis.

    Science.gov (United States)

    Overeem, S; Dalmau, J; Bataller, L; Nishino, S; Mignot, E; Verschuuren, J; Lammers, G J

    2004-01-13

    Idiopathic narcolepsy is associated with deficient hypocretin transmission. Narcoleptic symptoms have recently been described in paraneoplastic encephalitis with anti-Ma2 antibodies. The authors measured CSF hypocretin-1 levels in six patients with anti-Ma2 encephalitis, and screened for anti-Ma antibodies in patients with idiopathic narcolepsy. Anti-Ma autoantibodies were not detected in patients with idiopathic narcolepsy. Four patients with anti-Ma2 encephalitis had excessive daytime sleepiness; hypocretin-1 was not detectable in their cerebrospinal fluid, suggesting an immune-mediated hypocretin dysfunction.

  1. Construction of a high modulus asphalt (HiMA) trial section Ethekwini: South Africa's first practical experience with design, manufacturing and paving of HiMA

    CSIR Research Space (South Africa)

    Nkgapele, M

    2012-07-01

    Full Text Available A trial section was paved with the recently introduced High Modulus Asphalt (HiMA) technology on South Coast road in eThekwini (Durban). The trial section forms part of an effort to transfer HiMA technology to South Africa, in an initiative aimed...

  2. Global Paleobathymetry for the Cenomanian-Turonian (90 Ma)

    Science.gov (United States)

    Goswami, A.; Olson, P.; Hinnov, L. A.; Gnanadesikan, A.

    2014-12-01

    We present a paleo-ocean bathymetry reconstruction for Cenomanian-Turonian (90 Ma) time in a 0.1°x0.1° resolution for use in paleo-climate studies. Age of the ocean floor for the Cenomanian-Turonian (90 Ma) is from Müller et al. (2008 a,b); coastlines are from the PALEOMAP Project (Scotese, 2011). To reconstruct paleo-ocean bathymetry, we use a plate model equation to model depth to basement (Turcotte and Schubert, 2002). We estimate plate model equation parameter values from measurements of modern oceans (Crosby et al., 2006). On top of the depth to basement, we isostatically add a multilayer sediment model derived from area-corrected sediment thickness data (Divins, 2003; Whittaker et al., 2013). Lastly, we parameterize the modern continental shelf, slope, and rise in a "sediment wedge model" to connect the coastline with the closest ocean crust as defined by Müller et al. (2008 a, b). These parameters are defined using empirical relationships obtained from study of modern ocean transects where a complete rifting history is preserved (Atlantic and Southern oceans), and the closest approach of the respective oceanic crust (Müller et al., 2008a,b) to the coastline. We use the modern ocean as a test, comparing maps and cross sections of modern ocean bathymetry modeled using our reconstruction method with that of ETOPO1 (Amante and Eakins, 2009). Adding sea plateaus and seamounts minimize the difference between our modeled bathymetry and ETOPO1. Finally, we also present a comparison of our reconstructed paleo-bathymetry to that of Müller et al. (2008 a,b) for the Cenomanian-Turonian (90 Ma). References: Amante, C., Eakins, B.W., 2009, NOAA Tech. Memo. NESDIS NGDC-24, 19 p. Crosby, A., McKenzie, D., Sclater, J.G., 2006, Geophysical Journal Int. 166.2, 553-573. Divins, D., 2003, NOAA NGDC, Boulder, CO. Müller, R., Sdrolias, M., Gaina, C., Roest, W., 2008b, Geochemistry, Geophysics, Geosystems, 9, Q04006, doi:10.1029/2007GC001743 Müller, R., Sdrolias, M., Gaina

  3. SCHeMA open and modular in situ sensing solution

    Science.gov (United States)

    Tercier-Waeber, Marie Louise; Novellino, Antonio

    2017-04-01

    Marine environments are highly vulnerable and influenced by a wide diversity of anthropogenic and natural substances and organisms that may have adverse effects on the ecosystem equilibrium, on living resources and, ultimately, on human health. Identification of relevant types of hazards at the appropriate temporal and spatial scale is crucial to detect their sources and origin, to understand the processes governing their magnitude and distribution, and to ultimately evaluate and manage their risks and consequences preventing economic losses. This can be addressed only by the development of innovative, compact, rugged, automated, sensor networks allowing long-term monitoring. Development of such tools is a challenging task as it requires many analytical and technical innovations. The FP7-OCEAN 2013-SCHeMA project aims to contribute to meet this challenge by providing an open and modular sensing solution for autonomous in situ high resolution mapping of a range of anthropogenic and natural chemical compounds (trace metals, nutrients, anthropogenic organic compounds, toxic algae species and toxins, species relevant to the carbon cycle). To achieve this, SCHeMA activities focus on the development of : 1) an array of miniature sensor probes taking advantage of various innovative solutions, namely: (polymer-based) gel-integrated sensors; solid state ion-selective membrane sensors coupled to an on-line desalination module; mid-infrared optical sensors; optochemical multichannel devices; enOcean technology; 2) dedicated hardware, firmware and software components allowing their plug-and-play integration, localization as well as wireless bidirectional communication via advanced OGC-SWE wired/wireless dedicated interfaces; 3) a web-based front-end system compatible with EU standard requirements and principles (INSPIRE, GEO/GEOSS) and configured to insure easy interoperability with national, regional and local marine observation systems. This lecture will present examples of

  4. Sesli Okuma ve Konuşma Prozodisi: İlişkisel Bir Çalışma

    Directory of Open Access Journals (Sweden)

    Hasan Keskin

    2013-02-01

    Full Text Available Bu araştırma,  ilköğretim dördüncü sınıf öğrencilerinin sesli okuma ve konuşma prozodileri arasındaki ilişkiyi incelemek amacıyla ilişkisel tarama modelinde yapılmıştır. Araştırmaya,  Konya ve Afyonkarahisar’da ilköğretim dördüncü sınıfa devam eden 50 öğrenci katılmıştır.  Öğrencilerin sesli okumaları ve konuşmaları video ile kayıt altına alınmış, daha sonra bu kayıtlar üzerinde ölçekler aracılığıyla puanlamalar yapılmıştır. Sesli okuma ve konuşma prozodisi arasındaki ilişkiyi belirlemeye yönelik, Pearson Momentler Çarpım Korelasyon Tekniği kullanılmıştır. Analiz sonuçlarına göre, öğrencilerin sesli okuma ve konuşma prozodileri arasında, pozitif yönlü orta düzeyde bir ilişki çıkmıştır. Öğrencilerin sesli okumaları ve konuşma prozodi puanları cinsiyet açısından ayrı ayrı incelenmiş; kız ve erkek öğrencilerin ortalamaları arasında anlamlı bir farklılık çıkmamıştır. Ayrıca, öğrencilerin sesli okuma ve konuşmalarındaki prozodik düzeyi belirlemeye yönelik ölçümler yapılmıştır. Bu ölçüm sonuçlarına göre, araştırmaya katılan öğrencilerin %52’sinin sesli okuma prozodilerinin,  %48’inin ise konuşma prozodilerinin düşük düzeyde olduğu görülmüştür.

  5. Synthesis, biodistribution and in vitro evaluation of brain permeable high affinity type 2 cannabinoid receptor agonists [11C]MA2 and [18F]MA3

    Directory of Open Access Journals (Sweden)

    Muneer Ahamed

    2016-09-01

    Full Text Available Abstract The type 2 cannabinoid receptor (CB2 is a member of the endocannabinoid system and is known for its important role in (neuroinflammation. A PET-imaging agent that allows in vivo visualization of CB2 expression may thus allow quantification of neuroinflammation. In this paper, we report the synthesis, radiosynthesis, biodistribution and in vitro evaluation of a carbon-11 ([11C]MA2 and a fluorine-18 ([18F]MA3 labeled analogue of a highly potent N-arylamide oxadiazole CB2 agonist (EC50 = 0.015 nM. MA2 and MA3 behaved as potent CB2 agonist (EC50: 3 nM and 0.1 nM, respectively and their in vitro binding affinity for hCB2 was found to be 87 nM and 0.8 nM, respectively. Also MA3 (substituted with a fluoro ethyl group was found to have higher binding affinity and EC50 values when compared to the originally reported trifluoromethyl analogue 12. [11C]MA2 and [18F]MA3 were successfully synthesized with good radiochemical yield, high radiochemical purity and high specific activity. In mice, both tracers were efficiently cleared from blood and all major organs by the hepatobiliary pathway and importantly these compounds showed high brain uptake. In conclusion, [11C]MA2 and [18F]MA3 are shown to be high potent CB2 agonists with good brain uptake, these favorable characteristics makes them potential PET probes for in vivo imaging of brain CB2 receptors. However in view of its higher affinity and selectivity, further detailed evaluation of MA3 as a PET tracer for CB2 is warranted.

  6. Synthesis, Biodistribution and In vitro Evaluation of Brain Permeable High Affinity Type 2 Cannabinoid Receptor Agonists [11C]MA2 and [18F]MA3.

    Science.gov (United States)

    Ahamed, Muneer; van Veghel, Daisy; Ullmer, Christoph; Van Laere, Koen; Verbruggen, Alfons; Bormans, Guy M

    2016-01-01

    The type 2 cannabinoid receptor (CB2) is a member of the endocannabinoid system and is known for its important role in (neuro)inflammation. A PET-imaging agent that allows in vivo visualization of CB2 expression may thus allow quantification of neuroinflammation. In this paper, we report the synthesis, radiosynthesis, biodistribution and in vitro evaluation of a carbon-11 ([ 11 C]MA2) and a fluorine-18 ([ 18 F]MA3) labeled analog of a highly potent N -arylamide oxadiazole CB2 agonist (EC 50 = 0.015 nM). MA2 and MA3 behaved as potent CB2 agonist (EC 50 : 3 nM and 0.1 nM, respectively) and their in vitro binding affinity for h CB2 was found to be 87 nM and 0.8 nM, respectively. Also MA3 (substituted with a fluoro ethyl group) was found to have higher binding affinity and EC 50 values when compared to the originally reported trifluoromethyl analog 12 . [ 11 C]MA2 and [ 18 F]MA3 were successfully synthesized with good radiochemical yield, high radiochemical purity and high specific activity. In mice, both tracers were efficiently cleared from blood and all major organs by the hepatobiliary pathway and importantly these compounds showed high brain uptake. In conclusion, [ 11 C]MA2 and [ 18 F]MA3 are shown to be high potent CB2 agonists with good brain uptake, these favorable characteristics makes them potential PET probes for in vivo imaging of brain CB2 receptors. However, in view of its higher affinity and selectivity, further detailed evaluation of MA3 as a PET tracer for CB2 is warranted.

  7. Employment preferences of Lithuanian MA graduates in economic studies

    Directory of Open Access Journals (Sweden)

    Vaitiekus Novikevičius

    2009-12-01

    Full Text Available People may demonstrate preferences for different alternatives when choosing a workplace, for example: wages, career opportunities or workplace location. It is therefore important to determine which of the alternatives provides the maximum performance for the respondents. For this purpose, the authors have carried out extensive research of utility functions, originated theoretical models and / or employed practically. Unfortunately, there has been a lack of such research in Lithuania. The paper aims to examine the preferences and financial incentives based on the utility aspect Lithuanian master’s graduates in economic studies, including financial incentives, when they choose a workplace. The paper formulates the definition of the utility functions and the analysis its types. Moreover, it analyzes the utility functions of the MA graduates in economic studies from four universities, distinguishes their preferences and major financial incentives which give them the maximum utility.

  8. Random fields, topology, and the Imry-Ma argument.

    Science.gov (United States)

    Proctor, Thomas C; Garanin, Dmitry A; Chudnovsky, Eugene M

    2014-03-07

    We consider an n-component fixed-length order parameter interacting with a weak random field in d=1, 2, 3 dimensions. Relaxation from the initially ordered state and spin-spin correlation functions are studied on lattices containing hundreds of millions of sites. At n ≤ d the presence of topological defects leads to strong metastability and glassy behavior, with the final state depending on the initial condition. At n=d+1, when topological structures are nonsingular, the system possesses a weak metastability. At n>d+1, when topological objects are absent, the final, lowest-energy state is independent of the initial condition. It is characterized by the exponential decay of correlations that agrees quantitatively with the theory based upon the Imry-Ma argument.

  9. Cistanche deserticola Y. C. Ma, "Desert ginseng": a review.

    Science.gov (United States)

    Wang, Tian; Zhang, Xiaoying; Xie, Wenyan

    2012-01-01

    Cistanche deserticola Y. C. Ma (C. deserticola, "Rou Cong Rong" in Chinese) is an officinal plant that grows in arid or semi-arid areas. The dried fleshy stem of C. deserticola has been generally used as a tonic in China and Japan for many years. Modern pharmacology studies have since demonstrated that C. deserticola possesses broad medicinal functions, especially for use in hormone regulation, aperient, immunomodulatory, neuroprotective, antioxidative, anti-apoptotic, anti-nociceptive, anti-inflammatory, anti-fatigue activities and the promotion of bone formation. The phenylethanoid glycosides (PhGs) presented in C. deserticola have been identified as the major active components. This review summarizes the up-to-date and comprehensive information on C. deserticola covering the aspects of the botany, traditional uses, phytochemistry, and pharmacology.

  10. Feminist Sanatta Beden ve Yabancılaşma

    OpenAIRE

    Alp, Kafiye Özlem

    2015-01-01

    Feminizm, eril bir toplumda kadının, eşit hak ve özgürlüklere sahip olma gerekçelerine dayalı bir mücadele alanı olarak tanımlanabilir. Feminizmin, kamusal ve özel alanda kadın ayrımcılığına karşı başkaldırısı, insanın kendi emeğine ve kendi bedenine olan yabancılaşmasının bir sonucudur. Bu bakımdan feminizm, tüm tarihi boyunca toplumsal, felsefi, cinsel ve psikanalitik yabancılaşma kavramlarıyla yakın ilgi içinde olmuştur. Feminist sanat pratikleri; feminist kuramlar, toplumsal dinamikler...

  11. Traduire au cinéma (Rétrospective)

    OpenAIRE

    Kunz, Imma

    2016-01-01

    Cette étude, traduite de l’allemand par Maurice Voituriez, a été publiée dans le numéro 139 de Traduire (1989). N’ayant pas la télévision et me rendant rarement au cinéma, j’ai franchi allègrement le « seuil d’incompétence » en traduisant partiellement l’étude d’Imma Kunz sur l’activité cinématogra­phique de P.-F. Caillé. J’ai quand même vu les deux grands films qu’elle analyse du point de vue de la synchronisation. Je souhaite au lecteur de trouver autant de plaisir et d’intérêt à connaître ...

  12. Monothéismes et cinéma

    Directory of Open Access Journals (Sweden)

    Dominique Avon

    2012-06-01

    Full Text Available Monothéismes et cinéma sont deux termes qui ne sont pas couramment unis dans le champ des sciences humaines. Les uns mettent l’accent sur les conflits relatifs à ce qui est permis ou interdit dans les traditions religieuses, les autres soulignent le succès de films promus par des autorités religieuses. La problématique de ce numéro spécial est différente. Le fait est que le cinéma s’est développé principalement hors de l’influence des institutions religieuses. C’est donc à travers des critiques, des groupes de pressions, des sociétés, des magazines et des festivals, plus que par l’intermédiaire de réalisateurs ou d’acteurs, que chrétiens, juifs et –postérieurement- musulmans ont pris part à cette aventure moderne.“Monotheisms” and “cinema” are two words not commonly connected by a link in the field of the human sciences. On one side some people put the stress on conflicts about what is permitted and what is forbidden by religious traditions, on the other side other people underline success of films supported by religious authorities. The issue of this special topic is different. The fact is that cinema grew up mainly out of the influence of religious institutions. So, that is through lobbies, companies, magazines and special festivals more than through film directors or actors that Christians, Jews and –in a later time- Muslims as such have taken part to this modern adventure.

  13. Dietary supplements containing prohibited substances

    African Journals Online (AJOL)

    with information regarding dietary supplements and be advised to minimise risks for ... to promote strength and muscle mass, ... selective oestrogen receptor modulators or .... It has also come to the attention of the WADA that another sub-.

  14. Social Studies: Texts and Supplements.

    Science.gov (United States)

    Curriculum Review, 1979

    1979-01-01

    This review of selected social studies texts, series, and supplements, mainly for the secondary level, includes a special section examining eight titles on warfare and terrorism for grades 4-12. (SJL)

  15. Medicare and Medicaid Statistical Supplement

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CMS Office of Enterprise Data and Analytics (OEDA) produced an annual Medicare and Medicaid Statistical Supplement report providing detailed statistical...

  16. Bee Fauna and Floral Abundance Within Lawn-Dominated Suburban Yards in Springfield, MA.

    Science.gov (United States)

    Lerman, S B; Milam, J

    2016-09-01

    Private yards comprise a significant component of urban lands, with managed lawns representing the dominant land cover. Lawns blanket > 163,000 km 2 of the United States, and 50% of urban and suburban areas. When not treated with herbicides, lawns have the capacity to support a diversity of spontaneous (e.g., not planted) flowers, with the potential to provide nectar and pollen resources for pollinators such as native bees. In order to determine the extent to which suburban lawns support these important species, we surveyed lawns in 17 suburban yards in Springfield, MA, between May and September 2013 and 2014. Householders participating in the study did not apply chemical pesticides or herbicides to lawns for the duration of the study. We collected 5,331 individual bees, representing 111 species, and 29% of bee species reported for the state. The majority of species were native to North America (94.6%), nested in soil (73%), and solitary (48.6%). Species richness was lower for oligolectic (specialists on a single plant; 9.9%) and parasitic species (12.6%). Abundance percentages for number of individuals were similar. We documented 63 plant species in the lawns, the majority of which were not intentionally planted. The most abundant lawn flowers were dandelion ( Taraxacum officinale ) and clover ( Trifolium sp. ). Nearly 30% of the spontaneous plant species growing in the lawns were native to North America. Our study suggests that the spontaneous lawn flowers could be viewed as supplemental floral resources and support pollinators, thereby enhancing the value of urban green spaces.

  17. Technical committee on reactor physics of next generation. Examination of MA recycling by using PWRs

    International Nuclear Information System (INIS)

    Mori, Masaaki

    1995-01-01

    It is an important subject to be examined that during the period till full scale nuclear fuel recycling including the adoption of FBRs will be realized, we never have excess Pu. As the realistic examination considering the nuclear fuel recycling for the time being, the MOX fuel for PWRs of actinide recycling, ultralong life, placing emphasis on the concentrated charging of Pu and the confinement of MA in nuclear fuel cycling was examined. The change of the infinite multiplication rate of actinide recycling fuel is small throughout the burning, and there is the possibility of attaining the high burnup about twice of that of UO 2 fuel. The merit of the case of adding MA in small amount by recycling MA together with Pu at the proportion in spent fuel is shown. The amount of MA accumulation in Japan until 2050 was evaluated by the survey of the electric power generation of every reactor type using the long term reactor type strategy evaluation code LSER. By comparing the amount of MA accumulation in four MA recycling cases with the basic case without MA recycling, the amount of MA annihilation was evaluated. It was found that the MA recycling using PWRs only is not inferior to the multi-recycling of MA using FBRs. (K.I.)

  18. MA-burners efficiency parameters allowing for the duration of transmutation process

    International Nuclear Information System (INIS)

    Gulevich, A.; Zemskov, E.; Kalugin, A.; Ponomarev, L.; Seliverstov, V.; Seregin, M.

    2010-01-01

    Transmutation of minor actinides (MA) means their transforming into the fission products. Usually, MA-burner's transmutation efficiency is characterized by the static parameters only, such as the number of neutrons absorbed and the rate of MA feeding. However, the proper characterization of MA-burner's efficiency additionally requires the consideration of parameters allowing for the duration of the MA transmutation process. Two parameters of that kind are proposed: a) transmutation time τ - mean time period from the moment a mass of MA is loaded into the burner's fuel cycle to be transmuted to the moment this mass is completely transmuted; b) number of reprocessing cycles n rep - effective number of reprocessing cycles a mass of loaded MA has to undergo before being completely transmuted. Some of MA-burners' types have been analyzed from the point of view of these parameters. It turned out that all of them have the value of parameters too high from the practical point of view. It appears that some new approaches to MA-burner's design have to be used to significantly reduce the value of these parameters in order to make the large-scale MA transmutation process practically reasonable. Some of such approaches are proposed and their potential efficiency is discussed. (authors)

  19. MA-burners efficiency parameters allowing for the duration of transmutation process

    Energy Technology Data Exchange (ETDEWEB)

    Gulevich, A.; Zemskov, E. [Institute of Physics and Power Engineering, Bondarenko Square 1, Obninsk, Kaluga Region 249020 (Russian Federation); Kalugin, A.; Ponomarev, L. [Russian Research Center ' ' Kurchatov Institute' ' Kurchatov Square 1, Moscow 123182 (Russian Federation); Seliverstov, V. [Institute of Theoretical and Experimental Physics ul.B. Cheremushkinskaya 25, Moscow 117259 (Russian Federation); Seregin, M. [Russian Research Institute of Chemical Technology Kashirskoe Shosse 33, Moscow 115230 (Russian Federation)

    2010-07-01

    Transmutation of minor actinides (MA) means their transforming into the fission products. Usually, MA-burner's transmutation efficiency is characterized by the static parameters only, such as the number of neutrons absorbed and the rate of MA feeding. However, the proper characterization of MA-burner's efficiency additionally requires the consideration of parameters allowing for the duration of the MA transmutation process. Two parameters of that kind are proposed: a) transmutation time {tau} - mean time period from the moment a mass of MA is loaded into the burner's fuel cycle to be transmuted to the moment this mass is completely transmuted; b) number of reprocessing cycles n{sub rep} - effective number of reprocessing cycles a mass of loaded MA has to undergo before being completely transmuted. Some of MA-burners' types have been analyzed from the point of view of these parameters. It turned out that all of them have the value of parameters too high from the practical point of view. It appears that some new approaches to MA-burner's design have to be used to significantly reduce the value of these parameters in order to make the large-scale MA transmutation process practically reasonable. Some of such approaches are proposed and their potential efficiency is discussed. (authors)

  20. HERBAL SUPPLEMENTS: CAUSE FOR CONCERN?

    OpenAIRE

    Paolo Borrione; Luigi Di Luigi; Nicola Maffulli; Fabio Pigozzi

    2008-01-01

    More than 1400 herbal products or herbal-derived compounds are commonly commercialised for health uses worldwide (Tyler, 1996). Herbs are considered dietary supplements, and therefore are subjected to a very limited form of regulation, and advertisements normally highlight their potential activities without mentioning any side effect. Also, herbs are generally believed to be 'natural', and hence safe. Many nutritional supplements contains herb compounds usually not present in the diet (e.g. G...

  1. Vitamin D supplementation guidelines.

    Science.gov (United States)

    Pludowski, Pawel; Holick, Michael F; Grant, William B; Konstantynowicz, Jerzy; Mascarenhas, Mario R; Haq, Afrozul; Povoroznyuk, Vladyslav; Balatska, Nataliya; Barbosa, Ana Paula; Karonova, Tatiana; Rudenka, Ema; Misiorowski, Waldemar; Zakharova, Irina; Rudenka, Alena; Łukaszkiewicz, Jacek; Marcinowska-Suchowierska, Ewa; Łaszcz, Natalia; Abramowicz, Pawel; Bhattoa, Harjit P; Wimalawansa, Sunil J

    2018-01-01

    Research carried out during the past two-decades extended the understanding of actions of vitamin D, from regulating calcium and phosphate absorption and bone metabolism to many pleiotropic actions in organs and tissues in the body. Most observational and ecological studies report association of higher serum 25-hydroxyvitamin D [25(OH)D] concentrations with improved outcomes for several chronic, communicable and non-communicable diseases. Consequently, numerous agencies and scientific organizations have developed recommendations for vitamin D supplementation and guidance on optimal serum 25(OH)D concentrations. The bone-centric guidelines recommend a target 25(OH)D concentration of 20ng/mL (50nmol/L), and age-dependent daily vitamin D doses of 400-800IU. The guidelines focused on pleiotropic effects of vitamin D recommend a target 25(OH)D concentration of 30ng/mL (75nmol/L), and age-, body weight-, disease-status, and ethnicity dependent vitamin D doses ranging between 400 and 2000IU/day. The wise and balanced choice of the recommendations to follow depends on one's individual health outcome concerns, age, body weight, latitude of residence, dietary and cultural habits, making the regional or nationwide guidelines more applicable in clinical practice. While natural sources of vitamin D can raise 25(OH)D concentrations, relative to dietary preferences and latitude of residence, in the context of general population, these sources are regarded ineffective to maintain the year-round 25(OH)D concentrations in the range of 30-50ng/mL (75-125nmol/L). Vitamin D self-administration related adverse effects, such as hypercalcemia and hypercalciuria are rare, and usually result from taking extremely high doses of vitamin D for a prolonged time. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Mineral supplementation for grazing ruminants

    International Nuclear Information System (INIS)

    McDowell, L.R.; Conrad, J.H.; Ellis, G.L.

    1986-01-01

    Grazing ruminants to which concentrate feeds cannot be economically fed must rely on self-feeding of mineral supplements. A number of factors affect mineral consumption of free-choice mixtures. Livestock exhibit little nutritional wisdom and will select palatable mixtures in preference to mixtures designed to meet their requirements. Palatability and appetite stimulators are often used to achieve a more uniform herd-wide consumption. It is best to formulate free-choice mixtures on the basis of analyses or other available data. However, when no information on mineral status is known, a free-choice complete mineral supplement is warranted. A 'complete' mineral mixture usually includes salt, a low fluoride P source, Ca, Co, Cu, I, Mn and Zn. Selenium, Mg, K, S, Fe or additional elements can be incorporated into a mineral supplement as new information suggests a need. The detriment to ruminant production caused by providing Ca, Se and Cu in excess can be greater than any benefit derived by providing a mineral supplement. In regions where high forage Mo predominates, three to five times the Cu content in mineral mixtures is needed to counteract Mo toxicity. Supplemental minerals are most critical during the wet season, when cattle are gaining weight rapidly and energy and protein supplies are adequate. Economic return on mineral supplementation is high. (author)

  3. Cardiovascular Effects of Calcium Supplements

    Directory of Open Access Journals (Sweden)

    Ian R. Reid

    2013-07-01

    Full Text Available Calcium supplements reduce bone turnover and slow the rate of bone loss. However, few studies have demonstrated reduced fracture incidence with calcium supplements, and meta-analyses show only a 10% decrease in fractures, which is of borderline statistical and clinical significance. Trials in normal older women and in patients with renal impairment suggest that calcium supplements increase the risk of cardiovascular disease. To further assess their safety, we recently conducted a meta-analysis of trials of calcium supplements, and found a 27%–31% increase in risk of myocardial infarction, and a 12%–20% increase in risk of stroke. These findings are robust because they are based on pre-specified analyses of randomized, placebo-controlled trials and are consistent across the trials. Co-administration of vitamin D with calcium does not lessen these adverse effects. The increased cardiovascular risk with calcium supplements is consistent with epidemiological data relating higher circulating calcium concentrations to cardiovascular disease in normal populations. There are several possible pathophysiological mechanisms for these effects, including effects on vascular calcification, vascular cells, blood coagulation and calcium-sensing receptors. Thus, the non-skeletal risks of calcium supplements appear to outweigh any skeletal benefits, and are they appear to be unnecessary for the efficacy of other osteoporosis treatments.

  4. Ma ma (2015: un reflejo de la mujer española con cáncer de mama

    Directory of Open Access Journals (Sweden)

    Clara Peralta?Nueno et al.

    2017-03-01

    Full Text Available Ma ma (2015 es una película de drama española dirigida por Julio Medem y producida por Morena Films. Esta película narra la historia de la vida de Magda cuyo personaje es interpretado por Penélope Cruz. Tras serle diagnosticado un cáncer de mama, Magda, una maestra en paro, no sabrá cómo actuar ni de qué manera cambiará esta enfermedad su vida, pero poco a poco sacará a la superficie toda su energía vital. El cáncer de mama representa el tipo de cáncer más frecuente en la mujer. Aunque la mayoría de los factores de riesgo identificados pueden ser modificables, los sistemas de salud se concentran en actividades que permiten fortalecer la prevención primaria y actividades de prevención secundaria y terciaria. La detección temprana y el tratamiento adecuado son indispensables para luchar contra esta enfermedad. El proceso emocional generado por la presencia de cáncer, conlleva un mecanismo de reconstitución psíquico que permite a la paciente conformar una respuesta a los desafíos orgánicos, cognitivos, sociales y emocionales a los cuales se ve enfrentada. Dicho proceso es favorecido entre otros factores por contar con una red de apoyo socio?familiar sólida.

  5. 7 CFR 1955.22 - State supplements.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true State supplements. 1955.22 Section 1955.22 Agriculture... Real and Chattel Property § 1955.22 State supplements. State Supplements will be prepared with the... supplements will be submitted to the National Office for post approval in accordance with FmHA or its...

  6. 30 CFR 256.12 - Supplemental sales.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Supplemental sales. 256.12 Section 256.12..., General § 256.12 Supplemental sales. (a) The Secretary may conduct a supplemental sale in accordance with the provisions of this section. (b) Supplemental sales shall be governed by the regulations in this...

  7. 46 CFR 308.517 - Open Cargo Policy, Form MA-300.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Open Cargo Policy, Form MA-300. 308.517 Section 308.517... Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from the American War Risk...

  8. Development of a Hydronic Rooftop Unit-HyPak-MA

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Eric; Berman, Mark

    2009-11-14

    The majority of U.S. commercial floor space is cooled by rooftop HVAC units (RTUs). RTU popularity derives chiefly from their low initial cost and relative ease of service access without disturbing building occupants. Unfortunately, current RTUs are inherently inefficient due to a combination of characteristics that unnecessarily increase cooling loads and energy use. 36% percent of annual U.S. energy, and two-thirds of electricity, is consumed in and by buildings. Commercial buildings consume approximately 4.2 quads of energy each year at a cost of $230 billion per year, with HVAC equipment consuming 1.2 quads of electricity. More than half of all U.S. commercial floor space is cooled by packaged HVAC units, most of which are rooftop units (RTUs). Inefficient RTUs create an estimated 3.5% of U.S. CO{sub 2} emissions, thus contributing significantly to global warming5. Also, RTUs often fail to maintain adequate ventilation air and air filtration, reducing indoor air quality. This is the second HyPak project to be supported by DOE through NETL. The prior project, referred to as HyPak-1 in this report, had two rounds of prototype fabrication and testing as well as computer modeling and market research. The HyPak-1 prototypes demonstrated the high performance capabilities of the HyPak concept, but made it clear that further development was required to reduce heat exchanger cost and improve system reliability before HyPak commercialization can commence. The HyPak-1 prototypes were limited to about 25% ventilation air fraction, limiting performance and marketability. The current project is intended to develop a 'mixed-air' product that is capable of full 0-100% modulation in ventilation air fraction, hence it was referred to as HyPak-MA in the proposal. (For simplicity, the -MA has been dropped when referencing the current project.) The objective of the HyPak Project is to design, develop and test a hydronic RTU that provides a quantum improvement over

  9. Granulation study of porous silica particles for MA recovery process

    International Nuclear Information System (INIS)

    Goto, Ichiro; Kofuji, Hirohide; Oriuchi, Akio; Watanabe, Sou; Takeuchi, Masayuki

    2017-01-01

    JAEA has been working on partition of MA from HLLW generated in the reprocessing by extraction chromatography technology. This technology utilizes 50 μm porous silica particles coated by styrene-divinylbenzene copolymer in which an extractant for MA recovery is impregnated as adsorbent. In this study, spray drying granulating experiments with various operating conditions and with different experimental apparatuses were carried out to find an appropriate condition to control the size of the particle and the pore. The target average sizes of the particle and pore are more than 50 μm and 600 nm respectively. Suspension containing fine silica particles were supplied to the spray drying devices, and small droplets generated through the spray nozzle were dried inside the drying chamber. In this study, viscosity of the feed solution and some granulation conditions were parametrically changed, and two different types of the spray nozzles were used. An air atomizing nozzle and a rotary disk nozzle were equipped at different chambers respectively. Then, performance of the product particle was evaluated by particle and pore size distributions and adsorption experiment after the polymer coating and an extractant impregnation. The particle size of the product depended on the atomizing pressure and viscosity of the feed solution, and the size increased with decrease in the pressure and in the viscosity. The maximum size obtained in this study was about 40 μm. Large viscosity of the feed solution lead poor recovery ratio and uniformity in the size distribution of the product powder. The pore size of the resultant particle was 550-800 nm as expected. As the type of the nozzle changed from the air atomizing nozzle to the rotary disk nozzle and size of the drying chamber became large, the average particle size and the particle size distribution became large and sharp, respectively. Rotation speed of the nozzle also influenced on the particle size, and targeted average size of the

  10. Development of a dispersion strengthened copper alloy using a MA-HIP method

    Directory of Open Access Journals (Sweden)

    T. Yamada

    2016-12-01

    Full Text Available A new Cu-Al alloy was fabricated by a MA-HIP method for application to the heat sink materials of divertors. With the increase in MA time, the grain size and Vickers hardness decreased and increased, respectively. At MA time of 32hrs, the hardness of the alloy was comparable to that of Glidcop® although the grain size was much larger. X-ray diffractometry, electrical resistivity measurements and STEM-EDS analyses suggested precipitation of Al-rich phase by MA for 32hrs followed by HIP.

  11. Orchiectomy for suspected microscopic tumor in patients with anti-Ma2-associated encephalitis.

    Science.gov (United States)

    Mathew, R M; Vandenberghe, R; Garcia-Merino, A; Yamamoto, T; Landolfi, J C; Rosenfeld, M R; Rossi, J E; Thiessen, B; Dropcho, E J; Dalmau, J

    2007-03-20

    To report the presence of microscopic neoplasms of the testis in men with anti-Ma2-associated encephalitis (Ma2-encephalitis) and to discuss the clinical implications. Orchiectomy specimens were examined using immunohistochemistry with Ma2 and Oct4 antibodies. Among 25 patients with Ma2-encephalitis younger than 50 years, 19 had germ-cell tumors, and 6 had no evidence of cancer. These 6 patients underwent orchiectomy because they fulfilled five criteria: 1) demonstration of anti-Ma2 antibodies in association with MRI or clinical features compatible with Ma2-encephalitis, 2) life-threatening or progressive neurologic deficits, 3) age Ma2 was expressed by neoplastic cells in three of three patients examined. Even though most patients had severe neurologic deficits at the time of orchiectomy (median progression of symptoms, 10 months), 4 had partial improvement and prolonged stabilization (8 to 84 months, median 22.5 months) and two did not improve after the procedure. In young men with Ma2-encephalitis, 1) the disorder should be attributed to a germ-cell neoplasm of the testis unless another Ma2-expressing tumor is found, 2) negative tumor markers, ultrasound, body CT, or PET do not exclude an intratubular germ-cell neoplasm of the testis, and 3) if no tumor is found, the presence of the five indicated criteria should prompt consideration of orchiectomy.

  12. Računalniška izdelava ocenjevalne razdelitve na mednarodnih razstavah mačk

    OpenAIRE

    LAMPER, DEAN

    2018-01-01

    Na mednarodni razstavi mačk je potrebno prijavljene mačke razdeliti med sodnike, da jih ocenijo. Pri pripravi te razdelitve je potrebno upoštevati mnogo kriterijev, prijavljenih mačk pa je lahko nekaj sto. Zahtevnost priprave dobre razdelitve tako presega človeške zmožnosti, zato smo želeli razdelitev mačk med sodnike optimizirati z metodami umetne inteligence. V nalogi je predstavljeno nekaj algoritmov, ki jih je mogoče uporabiti za izdelavo ocenjevalne razdelitve na mednarodni razstavi m...

  13. Where is the happy Ending of Shāhnāma?

    OpenAIRE

    بهروز چمن آرا

    2015-01-01

    The renowned proverb “Shāhnāma axarash xoš ast” has implicit question which its answer may change our understanding of the nature and function of Shāhnāma. The end of Shāhnāma contains numerous tragic events in Sassanid age. Also it does not seem to be normal if the Iranians have deemed the bitter adventure of the Shahs and Pahlavāns as a happy ending like what Firdausi narrates at the end of his Shāhnāma. This article tries to reply the main question using an illustration on the story platfo...

  14. Polar mesosphere winter echoes during MaCWAVE

    Directory of Open Access Journals (Sweden)

    S. Kirkwood

    2006-07-01

    Full Text Available During the MaCWAVE winter campaign in January 2003, layers of enhanced echo power known as PMWE (Polar Mesosphere Winter Echoes were detected by the ESRAD 52 MHz radar on several occasions. The cause of these echoes is unclear and here we use observations by meteorological and sounding rockets and by lidar to test whether neutral turbulence or aerosol layers might be responsible. PMWE were detected within 30 min of meteorological rocket soundings (falling spheres on 5 separate days. The observations from the meteorological rockets show that, in most cases, conditions likely to be associated with neutral atmospheric turbulence are not observed at the heights of the PMWE. Observations by instrumented sounding rockets confirm low levels of turbulence and indicate considerable small-scale structure in charge density profiles. Comparison of falling sphere and lidar data, on the other hand, show that any contribution of aerosol scatter to the lidar signal at PMWE heights is less than the detection threshold of about 10%.

  15. El ayer, el hoy y el mañana

    Directory of Open Access Journals (Sweden)

    Corredor Pardo Katya Anyud

    1999-12-01

    Full Text Available

    Culturalmente, el anciano de hoy en nuestra sociedad, o en las grandes urbes, es considerado algunas veces por los jóvenes como un ser extraño y desagradable, como punto de partida de los  valores transmitidos en la familia los cuales deben ser revaluados y nosotros, los ancianos del mañana con los ancianos de hoy, cambiar de adentro hacia fuera. A su vez, evitar la transmisión generacional de estos valores a nuestros hijos realizando un análisis retrospectivo de la vida; cuando bebes, se tiene conciencia del uno al otro, y los niños en edad preescolar empiezan a conseguir compañeros, pero el grupo de amigos se fortalece a partir de los cinco o siete años, con frecuencia se escucha hablar con nostalgia de la vida en el colegio. Este lugar común es grato y feliz, adornado con carcajadas y anécdotas que despiertan e incentivan la imaginación y la realidad creada a partir del propio yo social, individual y cultural.

  16. Personal Hygiene Practices among Urban Homeless Persons in Boston, MA.

    Science.gov (United States)

    Leibler, Jessica H; Nguyen, Daniel D; León, Casey; Gaeta, Jessie M; Perez, Debora

    2017-08-18

    Persons experiencing homelessness in the United States experience significant barriers to self-care and personal hygiene, including limited access to clean showers, laundry and hand washing facilities. While the obstacles to personal hygiene associated with homelessness may increase risk of infectious disease, hygiene-related behaviors among people experiencing homelessness has received limited attention. We conducted a cross-sectional study of individuals experiencing homelessness in Boston, MA ( n = 194) to identify hygiene-related self-care practices and risk factors for reduced hygiene in this population. Most participants (72%) reported taking a daily shower. More than 60% reported hand washing with soap five or more times each day, and use of hand sanitizer was widespread (89% reported using sanitizer in the last week). A majority (86%) used a laundromat or laundry machine to wash clothing, while 14% reported washing clothing in the sink. Heavy drinking, injection drug use, and sleeping outdoors were identified as significant risk factors for reduced hygiene practices. People experiencing homelessness who also engage in these activities may be among the most difficult to reach for intervention, yet targeted efforts may decrease illness risk associated with reduced hygiene. Housed friends and family play a critical role in assisting homeless individuals maintain hygiene by providing showers and laundry facilities.

  17. Analysis of Homogeneous BFS-73-1 MA Benchmark Core

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yeong Il; Yoo, Jae Woon; Song, Hoon; Jang, Jin Wook; Kim, Yeong Il

    2007-06-15

    Analysis of BFS-73-1 critical assembly for MA transmutation has been carried out by using K-CORE system mainly, DIF3D code. All of measured data are compared with the results of analysis and sensitiveness of calculation conditions, for example, number of neutron energy groups, mesh size used, and analysis method, are assessed. Effective multiplication factor was in good agreement within experimental uncertainty in both transport and diffusion calculations. Fission rate distribution of U-235 and U-238 is also fairly good agreed with experimental results within maximum 5% in core region. But large discrepancy was seen in blanket region and it tends to increase as the location closes to core boundary. Largest error of relative reaction rate ratio was seen in Am-243 fission and U-238 capture. For the case of Am-243, the error lay on appropriate range considering the measurement uncertainty of that as 4.6%. Sample reactivity worths for scattering dominant isotope was greatly differ from the experimental results, which can be explained in terms of sample heterogeneity effect, sample self shielding and finally resonance bilinear correction effect. These effects will be evaluated as future study. C/E of effective delayed neutron fraction is within 4%, which is within the measurement uncertainty.

  18. Regioselective hydroxylation of isoflavones by Streptomyces avermitilis MA-4680.

    Science.gov (United States)

    Roh, Changhyun; Seo, Su-Hyun; Choi, Kwon-Young; Cha, Minho; Pandey, Bishnu Prasad; Kim, June-Hyung; Park, Jun-Seong; Kim, Duck Hee; Chang, Ih Seop; Kim, Byung-Gee

    2009-07-01

    Screening of bacterial whole cells was performed for regioselective hydroxylation of daidzein and genistein. Among the strains examined, Streptomyces avermitilis MA-4680 showed high ortho-dihydroxylation activity to produce 3',4',7-trihydroxyisoflavone and 3',4',5,7-tetrahydroxyisoflavone from daidzein (4',7-dihydroxyisoflavone) and genistein (4',5,7-trihydroxyisoflavone), respectively. Using 100 mg cells (wet wt.) and 1% (v/v) Triton X100 in 1 ml of total reaction volume, where 100 microl of the substrate solution (0.5 mM in 10% (v/v) mixed solvent of DMSO:MeOH = 3:7) was added to 900 microl of potassium phosphate buffer (100 mM, pH 7.2), a 16% molar conversion yield of 3',4',7-trihydroxyisoflavone was obtained from 0.5 mM daidzein after 24 h of reaction time at 28 degrees C and 200 rpm. Ketoconazole significantly (ca. 90%) inhibited the ortho-hydroxylation activity of daidzein, suggesting that cytochrome P450 enzymes putatively play roles in regiospecific daidzein hydroxylation. The analysis of the reaction products was determined by gas chromatography/mass spectrometry (GC/MS) and (1)H NMR.

  19. Report on the planning of Senegal's energy demand by MAED

    International Nuclear Information System (INIS)

    Kanouté, Mamadou

    2012-01-01

    This study was carried out to strengthen the capacities of the participants in the implementation of a global energy balance of a country using the MAED model. The training which saw the participation of two teams (Senegal and Mali) took place from 30 July to 17 August 2012. The aim of this study is to: 1. Develop future scenarios on the volution of energy consumption. 2. Propose concrete measures to enable the country to face Soaring prices of petroleum products. 3. Streamlining and distributing energy consumption in a safe and sustainable manner. 4. Better planning for energy demand. Also, this study showed that the household sector occupies the leading position in terms of energy consumption. The Agriculture sector does not consume much energy because of the lack of modernization that prevails in the agricultural process with the use of rudimentary tools when tractors are used in developed countries. However, given the objectives of the State of Senegal to revive the economy of Senegal, there are significant changes in all sectors. The share of agriculture in GDP tends to decline in the future as the share of services increases slightly. In the household sector, it should be stressed that the use of modern biomass tends to increase in the coming decades to the detriment of traditional fuels which follow a stagnant trend.

  20. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    International Nuclear Information System (INIS)

    Rathbone, Bruce A.

    2006-01-01

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at Hanford. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with 10 CFR 835, DOELAP, DOE-RL, ORP, PNSO, and Hanford contractor requirements. The dosimetry system is operated by PNNL's Hanford External Dosimetry Program which provides dosimetry services to all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. Rev. 0 marks the first revision to be released through PNNL's Electronic Records & Information Capture Architecture (ERICA) database

  1. SDSS IV MaNGA - Properties of AGN Host Galaxies

    Science.gov (United States)

    Sánchez, S. F.; Avila-Reese, V.; Hernandez-Toledo, H.; Cortes-Suárez, E.; Rodríguez-Puebla, A.; Ibarra-Medel, H.; Cano-Díaz, M.; Barrera-Ballesteros, J. K.; Negrete, C. A.; Calette, A. R.; de Lorenzo-Cáceres, A.; Ortega-Minakata, R. A.; Aquino, E.; Valenzuela, O.; Clemente, J. C.; Storchi-Bergmann, T.; Riffel, R.; Schimoia, J.; Riffel, R. A.; Rembold, S. B.; Brownstein, J. R.; Pan, K.; Yates, R.; Mallmann, N.; Bitsakis, T.

    2018-04-01

    We present the characterization of the main properties of a sample of 98 AGN host galaxies, both type-II and type-I, in comparison with those of ≍2700 non-active galaxies observed by the MaNGA survey. We found that AGN hosts are morphologically early-type or early-spirals. AGN hosts are, on average, more massive, more compact, more centrally peaked and more pressure-supported systems. They are located in the intermediate/transition region between starforming and non-star-forming galaxies (i.e., the so-called green valley). We consider that they are in the process of halting/quenching the star formation. The analysis of the radial distributions of different properties shows that the quenching happens from inside-out involving both a decrease of the effciency of the star formation and a deficit of molecular gas. The data-products of the current analysis are distributed as a Value Added Catalog within the SDSS-DR14.

  2. MaMBA - a functional Moon and Mars Base Analog

    Science.gov (United States)

    Heinicke, C.; Foing, B.

    2017-09-01

    Despite impressive progress in robotic exploration of celestial bodies, robots are believed to never reach the effectiveness and efficiency of a trained human. Consequently, ESA proposes to build an international Moon Village in roughly 15 years and NASA plans for the first manned mission to Mars shortly after. One of the challenges still remaining is the need for a shelter, a habitat which allows human spacefarers to safely live and work on the surface of a celestial body. Although a number of prototype habitats has been built during the last decades and inhabited for various durations (e.g. MDRS, FMARS, HI-SEAS, M.A.R.S.), these habitats are typically equipped for studies on human factors and would not function in an extraterrestrial environment. Project MaMBA (Moon and Mars Base Analog) aims to build the first functional habitat based on the lessons learned from intermediate and long duration missions at the mentioned habitats. The habitat will serve for testing technologies like life support, power systems, and interplanetary communi­cation. Special attention will be given to the develop­ment of the geoscience laboratory module. Crews will live and work inside the habitat to ensure its functionality.

  3. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    Energy Technology Data Exchange (ETDEWEB)

    Rathbone, Bruce A.

    2005-02-25

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at Hanford. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with 10 CFR 835, DOELAP, DOE-RL, ORP, PNSO, and Hanford contractor requirements. The dosimetry system is operated by PNNL’s Hanford External Dosimetry Program which provides dosimetry services to all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. Rev. 0 marks the first revision to be released through PNNL’s Electronic Records & Information Capture Architecture (ERICA) database.

  4. Voix over et peur au cinéma

    Directory of Open Access Journals (Sweden)

    Martin Barnier

    2012-07-01

    Full Text Available Les voix over de narration peuvent servir à effrayer les spectateurs de cinéma. Depuis les bonimenteurs-conférenciers des salles d’avant 1914, jusqu’aux films d’horreur des années 1970, en passant par les films des années 1930 et 1940, les voix placées sur des images peuvent créer une atmosphère lugubre. Le contraste entre une voix susurrée et des images pleines de suspens, est générateur d’angoisse. Des exemples tirés de films de Lang, Hitchcock, Tourneur, ou de cinéastes bien moins connus, permettent de vérifier que les voix over s’intègrent dans une longue tradition mais qu’elles évoluent constamment.Voice over can be use to frighten movie audiences. From the film lecturer before 1914 to the 1970s Horror movies, voices accompanying images can create a gloomy atmosphere. Contrast between suspenseful images and a whispering voice can generate fear. With examples taken from Lang, Hitchcock, Tourneur, and unknown directors, we will show that voice over creates fear since a long tradition. But each time it evolves in a different way.

  5. Analysis of Homogeneous BFS-73-1 MA Benchmark Core

    International Nuclear Information System (INIS)

    Kim, Yeong Il; Yoo, Jae Woon; Song, Hoon; Jang, Jin Wook; Kim, Yeong Il

    2007-06-01

    Analysis of BFS-73-1 critical assembly for MA transmutation has been carried out by using K-CORE system mainly, DIF3D code. All of measured data are compared with the results of analysis and sensitiveness of calculation conditions, for example, number of neutron energy groups, mesh size used, and analysis method, are assessed. Effective multiplication factor was in good agreement within experimental uncertainty in both transport and diffusion calculations. Fission rate distribution of U-235 and U-238 is also fairly good agreed with experimental results within maximum 5% in core region. But large discrepancy was seen in blanket region and it tends to increase as the location closes to core boundary. Largest error of relative reaction rate ratio was seen in Am-243 fission and U-238 capture. For the case of Am-243, the error lay on appropriate range considering the measurement uncertainty of that as 4.6%. Sample reactivity worths for scattering dominant isotope was greatly differ from the experimental results, which can be explained in terms of sample heterogeneity effect, sample self shielding and finally resonance bilinear correction effect. These effects will be evaluated as future study. C/E of effective delayed neutron fraction is within 4%, which is within the measurement uncertainty

  6. Vitamin C supplementation in pregnancy.

    Science.gov (United States)

    Rumbold, Alice; Ota, Erika; Nagata, Chie; Shahrook, Sadequa; Crowther, Caroline A

    2015-09-29

    Vitamin C supplementation may help reduce the risk of pregnancy complications such as pre-eclampsia, intrauterine growth restriction and maternal anaemia. There is a need to evaluate the efficacy and safety of vitamin C supplementation in pregnancy. To evaluate the effects of vitamin C supplementation, alone or in combination with other separate supplements on pregnancy outcomes, adverse events, side effects and use of health resources. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 March 2015) and reference lists of retrieved studies. All randomised or quasi-randomised controlled trials evaluating vitamin C supplementation in pregnant women. Interventions using a multivitamin supplement containing vitamin C or where the primary supplement was iron were excluded. Two review authors independently assessed trials for inclusion and risk of bias, extracted data and checked them for accuracy. Twenty-nine trials involving 24,300 women are included in this review. Overall, 11 trials were judged to be of low risk of bias, eight were high risk of bias and for 10 trials it was unclear. No clear differences were seen between women supplemented with vitamin C alone or in combination with other supplements compared with placebo or no control for the risk of stillbirth (risk ratio (RR) 1.15, 95% confidence intervals (CI) 0.89 to 1.49; 20,038 participants; 11 studies; I² = 0%; moderate quality evidence), neonatal death (RR 0.79, 95% CI 0.58 to 1.08; 19,575 participants; 11 studies; I² = 0%), perinatal death (average RR 1.07, 95% CI 0.77 to 1.49; 17,105 participants; seven studies; I² = 35%), birthweight (mean difference (MD) 26.88 g, 95% CI -18.81 to 72.58; 17,326 participants; 13 studies; I² = 69%), intrauterine growth restriction (RR 0.98, 95% CI 0.91 to 1.06; 20,361 participants; 12 studies; I² = 15%; high quality evidence), preterm birth (average RR 0.99, 95% CI 0.90 to 1.10; 22,250 participants; 16 studies; I² = 49%; high quality evidence

  7. Boron supplementation in broiler diets

    Directory of Open Access Journals (Sweden)

    EJ Fassani

    2004-12-01

    Full Text Available Boron supplementation in broiler feed is not a routine practice. However, some reports suggest a positive effect of boron on performance. This study assessed the effects of boron supplementation on broiler performance. Diets were based on maize and soybean meal, using boric acid P.A. as boron source. Six supplementation levels (0, 30, 60, 90, 120 and 150 ppm were evaluated using 1,440 one-day old males housed at a density of 30 chickens in each of 48 experimental plots of 3m². A completely randomized block design was used with 8 replicates. Feed intake, weight gain and feed conversion were assessed in the periods from 1 to 7 days, 1 to 21 days and 1 to 42 days of age, and viability was evaluated for the total 42-day rearing period. No performance variable was affected by boron supplementation (p>0.05 in the period from 1 to 7 days. The regression analysis indicated an ideal level of 37.4 ppm of boron for weight gain from 1 to 21 days (p0.05, although feed intake was reduced linearly with increased boron levels (p0.05. Ash and calcium percentages in the tibias of broilers and viability in the total rearing period were not affected by boron supplementation (p>0.05.

  8. Prohibited Contaminants in Dietary Supplements.

    Science.gov (United States)

    Mathews, Neilson M

    With the increasing use of unregulated dietary supplements, athletes are at continued risk from adverse medical events and inadvertent doping. A review of Clinical Key, MEDLINE, and PubMed databases from 2012 to 2017 was performed using search terms, including dietary supplement, contamination, doping in athletes, inadvertent doping, and prohibited substances. The references of pertinent articles were reviewed for other relevant sources. Clinical review. Level 3. Poor manufacturing processes and intentional contamination with many banned substances continue to occur in dietary supplements sold in the United States. Certain sectors, such as weight loss and muscle-building supplements, pose a greater threat because they are more likely to be contaminated. Athletes will continue to be at risk for adverse events and failed doping tests due to contaminated dietary supplements until legislation changes how they are regulated. In the interim, there are several steps that can be taken to mitigate this risk, including improved education of medical staff and athletes and use of third party-certified products.

  9. Synthesis of 9,9,9-trideutero-1,4-dihydroxynonane mercapturic acid (d3-DHN-MA), a useful internal standard for DHN-MA urinalysis.

    Science.gov (United States)

    Chantegrel, B; Deshayes, C; Doutheau, A; Steghens, J P

    2002-10-01

    Racemic 1,4-dihydroxynonane mercapturic acid (DHN-MA) and 9,9,9-trideutero-1,4-dihydroxynonane mercapturic acid (d3-DHN-MA) are synthesized on a 400-mg scale (overall yield approximately 40%) by a two-step sequence involving Michael addition of N-acetyl-L-cysteine to methyl 4-hydroxynon-2(E)-enoate or methyl 9,9,9-trideutero-4-hydroxynon-2 (E)-enoate, followed by reduction of the intermediate adducts with lithium borohydride. The requisite starting methyl esters are obtained, respectively, from heptanal or 7,7,7-trideuteroheptanal and methyl 4-chlorophenylsulfinylacetate via a sulfoxide piperidine and carbonyl reaction described in the literature. The 7,7,7-trideuteroheptanal is easily prepared by classical methods in four steps from 6-bromo-1-hexanol. 13C NMR data indicate that DHN-MA as well as d3-DHN-MA are obtained as mixtures of four diastereomers. Preliminary results show that d3-DHN-MA could be used as an internal standard for mass spectrometric quantification of DHN-MA in human urine.

  10. Influence of HMB supplementation and resistance training on cytokine responses to resistance exercise.

    Science.gov (United States)

    Kraemer, William J; Hatfield, Disa L; Comstock, Brett A; Fragala, Maren S; Davitt, Patrick M; Cortis, Cristina; Wilson, Jacob M; Lee, Elaine C; Newton, Robert U; Dunn-Lewis, Courtenay; Häkkinen, Keijo; Szivak, Tunde K; Hooper, David R; Flanagan, Shawn D; Looney, David P; White, Mark T; Volek, Jeff S; Maresh, Carl M

    2014-01-01

    The purpose of this study was to determine the effects of a multinutritional supplement including amino acids, β-hydroxy-β-methylbutyrate (HMB), and carbohydrates on cytokine responses to resistance exercise and training. Seventeen healthy, college-aged men were randomly assigned to a Muscle Armor™ (MA; Abbott Nutrition, Columbus, OH) or placebo supplement group and 12 weeks of resistance training. An acute resistance exercise protocol was administered at 0, 6, and 12 weeks of training. Venous blood samples at pre-, immediately post-, and 30-minutes postexercise were analyzed via bead multiplex immunoassay for 17 cytokines. After 12 weeks of training, the MA group exhibited decreased interferon-gamma (IFN-γ) and interleukin (IL)-10. IL-1β differed by group at various times. Granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-6, IL-7, IL-8, IL-12p70, IL-13, IL-17, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-1 beta (MIP-1β) changed over the 12-week training period but did not differ by group. Twelve weeks of resistance training alters the cytokine response to acute resistance exercise, and supplementation with HMB and amino acids appears to further augment this result.

  11. Is vitamin C supplementation beneficial?

    DEFF Research Database (Denmark)

    Lykkesfeldt, Jens; Poulsen, Henrik Enghusen

    2010-01-01

    of the benefit:harm ratio of antioxidant supplements. We have examined the literature on vitamin C intervention with the intention of drawing a conclusion on its possible beneficial or deleterious effect on health and the result is discouraging. One of several important issues is that vitamin C uptake is tightly...... controlled, resulting in a wide-ranging bioavailability depending on the current vitamin C status. Lack of proper selection criteria dominates the currently available literature. Thus, while supplementation with vitamin C is likely to be without effect for the majority of the Western population due...... to saturation through their normal diet, there could be a large subpopulation with a potential health problem that remains uninvestigated. The present review discusses the relevance of the available literature on vitamin C supplementation and proposes guidelines for future randomised intervention trials....

  12. Nutritional Supplements for Strength Power Athletes

    Science.gov (United States)

    Wilborn, Colin

    Over the last decade research involving nutritional supplementation and sport performance has increased substantially. Strength and power athletes have specific needs to optimize their performance. Nutritional supplementation cannot be viewed as a replacement for a balanced diet but as an important addition to it. However, diet and supplementation are not mutually exclusive, nor does one depend on the other. Strength and power athletes have four general areas of supplementation needs. First, strength athletes need supplements that have a direct effect on performance. The second group of supplements includes those that promote recovery. The third group comprises the supplements that enhance immune function. The last group of supplements includes those that provide energy or have a direct effect on the workout. This chapter reviews the key supplements needed to optimize the performance and training of the strength athlete.

  13. [Quality control in herbal supplements].

    Science.gov (United States)

    Oelker, Luisa

    2005-01-01

    Quality and safety of food and herbal supplements are the result of a whole of different elements as good manufacturing practice and process control. The process control must be active and able to individuate and correct all possible hazards. The main and most utilized instrument is the hazard analysis critical control point (HACCP) system the correct application of which can guarantee the safety of the product. Herbal supplements need, in addition to standard quality control, a set of checks to assure the harmlessness and safety of the plants used.

  14. The effect of supplementing untreated, urea-supplemented and urea ...

    African Journals Online (AJOL)

    3x2x2 factorial experiment, involving an intake and in vivo digestibility trial with 48 adult S.A. Mutton Merino wethers. Straw dry matter (OM) intake on ammoniated wheat-straw diets was 27 and 22% higher (P ';;0,01) than on untreated and urea-supplemented diets, respectively. No significant difference was found between ...

  15. A Metabolomic Strategy to Screen the Prototype Components and Metabolites of Shuang-Huang-Lian Injection in Human Serum by Ultra Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Mingxing Guo

    2014-01-01

    Full Text Available Shuang-huang-lian injection (SHLI is a famous Chinese patent medicine, which has been wildly used in clinic to treat acute respiratory tract infection, pneumonia, influenza, and so forth. Despite the widespread clinical application, the prototype components and metabolites of SHLI have not been fully elucidated, especially in human body. To discover and screen the constituents or metabolites of Chinese medicine in biofluids tends to be more and more difficult due to the complexity of chemical compositions, metabolic reactions and matrix effects. In this work, a metabolomic strategy to comprehensively elucidate the prototype components and metabolites of SHLI in human serum conducted by UPLC-Q-TOF/MS was developed. Orthogonal partial least squared discriminant analysis (OPLS-DA was applied to distinguish the exogenous, namely, drug-induced constituents, from endogenous in human serum. In the S-plot, 35 drug-induced constituents were found, including 23 prototype compounds and 12 metabolites which indicated that SHLI in human body mainly caused phase II metabolite reactions. It was concluded that the metabolomic strategy for identification of herbal constituents and metabolites in biological samples was successfully developed. This identification and structural elucidation of the chemical compounds provided essential data for further pharmacological and pharmacokinetics study of SHLI.

  16. Festivals de cinéma dans le monde arabe

    Directory of Open Access Journals (Sweden)

    Jean-Michel Frodon

    2013-12-01

    Full Text Available Alors que les deux grands festivals « historiques » du monde arabe, Carthage (JCC et Le Caire, sont entrés en décadence, on assiste depuis le début des années 2000 à une véritable explosion du phénomène festivalier dans le monde arabe. Le pays le plus en pointe est le Maroc, quoique de manière contrastée, avec une manifestation de prestige à Marrakech, et une nuée de petites manifestations. Dans les émirats du Golfe, la multiplication des festivals traduit une stratégie de communication plutôt qu’une volonté de développement culturel. Cette stratégie est fragilisée par la concurrence que se livrent les différents acteurs. Dans les autres pays arabes, on trouve une grande variété de situations sous le signe de la dispersion. Pourtant, l’accumulation de festivals (une centaine dans la région finit par avoir des effets d’ensemble, au-delà des buts, moyens et limites de chacun d’eux. Le phénomène festivalier, bien qu’inscrit dans des agendas locaux ou nationaux, génère de manière plus vaste des réseaux générationnels, financiers, de procédures d’expertise, de processus d’interrelation, géographiques mais aussi entre le cinéma et les autres arts ou médias.

  17. Science and technology of the 10-MA spherical tori

    International Nuclear Information System (INIS)

    Peng, M.; Reiersen, W.; Kaye, S.

    1999-01-01

    The scientific parameters and the technology issues for a modest-size Spherical Torus (ST) at 10 MA in plasma current are discussed. This class of devices include a D-T-capable ST experiments (DTST, R 0 = 1.2 m) for Proof of Performance for limited pulse lengths and neutron fluences, and a steady-state volume neutron source (VNS, R 0 = 1.1 m) for testing Fusion Energy Components to high neutron fluences. The scientific issues of interest to the DTST include noninductive ramp up of plasma current in a limited time scale (∼40 s), confinement needed for high-Q burn, behavior of energetic particles, physics and techniques to handle intense plasma exhaust, and the possibility of high performance plasma regimes free of disruptions or large disruption impact. Also of interest to the VNS would be steady state operation using large external current drive possibly at a modest Q (∼ 1-2) achieving significant neutron wall loading (∼1 MW/m 2 ) and a configuration relatively amenable for remote maintenance. A much longer time scale would be permitted for noninductive current ramp up. The center leg of the TF coils, possibly multi-turn for DTST and necessarily single-turn for VNS without significant nuclear shielding, is a technical and material issue of unique importance to the ST. Positive-ion Neutral Beam Injection (NBI) and HHFW (∼80 MHz) heating and current drive systems already available to date are likely adequate for the DTST following pulse length extension to ∼50 s. For the high densities needed for enhancing the neutron wall loading (to ∼ a few MW/m 2 ) in a VNS, a negative-ion NBI system may become desired. Given an adequate physics database, the remaining enabling technologies needed by the VNS appear largely similar in nature to those of the ITER EDA design. (author)

  18. Science and technology of the 10-MA Spherical Tori

    International Nuclear Information System (INIS)

    Peng, M.; Reiersen, W.; Kaye, S.

    2001-01-01

    The scientific parameters and the technology issues for a modest-size Spherical Torus (ST) at 10 MA in plasma current are discussed. This class of devices include a D-T-capable ST experiments (DTST, R 0 =1.2 m) for Proof of Performance for limited pulse lengths and neutron fluences, and a steady-state volume neutron source (VNS, R 0 =1.1 m) for testing Fusion Energy Components to high neutron fluences. The scientific issues of interest to the DTST include noninductive ramp up of plasma current in a limited time scale (∼40 s), confinement needed for high-Q burn, behavior of energetic particles, physics and techniques to handle intense plasma exhaust, and the possibility of high performance plasma regimes free of disruptions or large disruption impact. Also of interest to the VNS would be steady state operation using large external current drive possibly at a modest Q (∼1-2) achieving significant neutron wall loading (∼1MW/m 2 ) and a configuration relatively amenable for remote maintenance. A much longer time scale would be permitted for noninductive current ramp up. The center leg of the TF coils, possibly multi-turn for DTST and necessarily single-turn for VNS without significant nuclear shielding, is a technical and material issue of unique importance to the ST. Positive-ion Neutral Beam Injection (NBI) and HHFW (∼80 MHz) heating and current drive systems already available to date are likely adequate for the DTST following pulse length extension to ∼50 s. For the high densities needed for enhancing the neutron wall loading (to ∼ a few MW/m 2 ) in a VNS, a negative-ion NBI system may become desired. Given an adequate physics database, the remaining enabling technologies needed by the VNS appear largely similar in nature to those of the ITER EDA design. (author)

  19. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    Energy Technology Data Exchange (ETDEWEB)

    Rathbone, Bruce A.

    2009-08-28

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at Hanford. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with 10 CFR 835, DOELAP, DOE-RL, ORP, PNSO, and Hanford contractor requirements. The dosimetry system is operated by PNNL’s Hanford External Dosimetry Program (HEDP) which provides dosimetry services to all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee (HPDAC) which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. The first revision to be released through PNNL’s Electronic Records & Information Capture Architecture (ERICA) database was designated Revision 0. Revision numbers that are whole numbers reflect major revisions typically involving changes to all chapters in the document. Revision numbers that include a decimal fraction reflect minor revisions, usually restricted to selected chapters or selected pages in the document.

  20. Mercury Cycling in Salt Marsh Pond Ecosystems: Cape Cod, MA

    Science.gov (United States)

    Ganguli, P. M.; Gonneea, M. E.; Lamborg, C. H.; Kroeger, K. D.; Swarr, G.; Vadman, K. J.; Baldwin, S.; Brooks, T. W.; Green, A.

    2014-12-01

    We are measuring total mercury (HgT) and monomethylmercury (CH3Hg+ or MMHg) in pore water, surface water, and sediment cores from two salt marsh pond systems on the south shore of Cape Cod, MA to characterize the distribution of mercury species and to identify features that influence mercury speciation and transport. Sage Lot Pond is relatively undisturbed and has low nitrogen loading (12 kg ha-1 y-1). It is part of the Waquoit Bay National Estuarine Reserve and is surrounded by undeveloped wooded uplands. In contrast, Great Pond is highly impacted. Nitrogen loading to the site is elevated (600 kg ha-1 y-1) and the marsh is adjacent to a large residential area. In both systems, a 1 to 2 m organic-rich peat layer overlies the permeable sand aquifer. Groundwater in this region is typically oxic, where pore water within salt marsh peat is suboxic to anoxic. We hypothesize that redox gradients at the transition from the root zone to peat and at the peat-sand interface may provide habitat for MMHg-producing anaerobic bacteria. Preliminary results from a 2-m nearshore depth profile at Sage Lot Pond indicate HgT in groundwater within the sand aquifer occurred primarily in the > 0.2 μm fraction, with unfiltered concentrations exceeding 100 pM. Filtered (fraction of filtered HgT in peat pore water. Although MMHg in both groundwater and pore water remained around 1 pM throughout our depth profile, we observed an increase in sediment MMHg (0.3 to 1.6 μg/kg) at the peat-sand interface. MMHg comprised ~50% of the HgT concentration in pore water suggesting mercury in the salt marsh peat is biologically available.

  1. Organising and learning experiences of the first semester MA Program ePedagogy / Visual Knowledge Building

    NARCIS (Netherlands)

    Jaap Jansen

    2006-01-01

    This paper will discuss the process of the MA program ePedagogy / Visual Knowledge Building during the first semester of the academic year 2005 – 2006. This MA program is a joint venture between the Universities of Helsinki, Hamburg and INHOLLAND. This publication will discuss and evaluate the

  2. European Master's Program in Gerontology (EuMaG): Goals, Curriculum, and Students

    Science.gov (United States)

    Aartsen, Marja

    2011-01-01

    The European Master's Program in Gerontology (EuMaG) started in September 2003 with support from the European Commission. The EuMaG is a modular, 2-year, part-time international training program about the aging process and its societal implications. The multidisciplinary curriculum comprises four domains of gerontology (i.e., social gerontology,…

  3. European Master's program in Gerontology (EuMaG): Goals, curriculum, and students

    NARCIS (Netherlands)

    Aartsen, M.J.

    2011-01-01

    The European Master's Program in Gerontology (EuMaG) started in September 2003 with support from the European Commission. The EuMaG is a modular, 2-year, part-time international training program about the aging process and its societal implications. The multidisciplinary curriculum comprises four

  4. 77 FR 29251 - Safety Zone; Carnival Fireworks Display, Nantasket Beach, Hull, MA

    Science.gov (United States)

    2012-05-17

    ...-AA00 Safety Zone; Carnival Fireworks Display, Nantasket Beach, Hull, MA AGENCY: Coast Guard, DHS... zone on the navigable waters off of Nantasket Beach in the vicinity of Hull, MA for a Carnival... spectators and vessels from the hazards associated with fireworks displays. Discussion of Proposed Rule Hull...

  5. 46 CFR 308.522 - Collateral deposit fund, letter of transmittal, Form MA-302.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Collateral deposit fund, letter of transmittal, Form MA... Collateral deposit fund, letter of transmittal, Form MA-302. The standard form of letter of transmittal for use in establishing a collateral deposit fund, may be obtained from the American War Risk Agency or...

  6. Implications of progesterone metabolism in MA-10 cells for accurate measurement of the rate of steroidogenesis

    NARCIS (Netherlands)

    F.F.G. Rommerts (Focko); S.R. King (Steven); P.N. Span (Paul)

    2001-01-01

    textabstractIn virtually all studies with MA-10 cells, progesterone RIAs have been used to measure steroid synthesis. To test whether progesterone is a stable end product, we investigated the metabolism of added tritiated progesterone and pregnenolone in MA-10 cells over a period

  7. Implications of progesterone metabolism in MA-10 cells for accurate measurement of the rate of steroidogenesis.

    NARCIS (Netherlands)

    Rommerts, F.F.; King, S.R.; Span, P.N.

    2001-01-01

    In virtually all studies with MA-10 cells, progesterone RIAs have been used to measure steroid synthesis. To test whether progesterone is a stable end product, we investigated the metabolism of added tritiated progesterone and pregnenolone in MA-10 cells over a period of 3 h. Steroids were then

  8. MaMiCo: Software design for parallel molecular-continuum flow simulations

    KAUST Repository

    Neumann, Philipp; Flohr, Hanno; Arora, Rahul; Jarmatz, Piet; Tchipev, Nikola; Bungartz, Hans-Joachim

    2015-01-01

    The macro-micro-coupling tool (MaMiCo) was developed to ease the development of and modularize molecular-continuum simulations, retaining sequential and parallel performance. We demonstrate the functionality and performance of MaMiCo by coupling

  9. Ma'atic Beauty: Ethics and Aesthetics of the Ancient Egyptians in Ayi ...

    African Journals Online (AJOL)

    ... Ma'at cannot be disconnected from debates over narratives of anti-colonial and postcolonial conflicts. Indeed, Armah reveals that far from being marooned into a state of archaic, timeless and unchanging tradition, Ma'at has the potential to shape and enhance a sound and inspiring ethical code for nowadays Africans.

  10. Anti-Ma-associated encephalitis due to dysgerminoma in a woman with Swyer syndrome.

    Science.gov (United States)

    Al-Thubaiti, Ibtisam; Al-Hayek, Kefah; Binfalah, Mohammed

    2013-04-09

    Paraneoplastic limbic encephalitis (PLE)/diencephalitis associated with anti-Ma2 antibodies was linked to testicular cancer and non-small-cell lung cancer (non-SCLC).(1,2) We report a case of anti-Ma-associated PLE/diencephalitis due to dysgerminoma in a woman with gonadal dysgenesis, or Swyer syndrome.

  11. Patent Analysis for Supporting Merger and Acquisition (M&A) Prediction: A Data Mining Approach

    Science.gov (United States)

    Wei, Chih-Ping; Jiang, Yu-Syun; Yang, Chin-Sheng

    M&A plays an increasingly important role in the contemporary business environment. Companies usually conduct M&A to pursue complementarity from other companies for preserving and/or extending their competitive advantages. For the given bidder company, a critical first step to the success of M&A activities is the appropriate selection of target companies. However, existing studies on M&A prediction incur several limitations, such as the exclusion of technological variables in M&A prediction models and the omission of the profile of the respective bidder company and its compatibility with candidate target companies. In response to these limitations, we propose an M&A prediction technique which not only encompasses technological variables derived from patent analysis as prediction indictors but also takes into account the profiles of both bidder and candidate target companies when building an M&A prediction model. We collect a set of real-world M&A cases to evaluate the proposed technique. The evaluation results are encouraging and will serve as a basis for future studies.

  12. 46 CFR 308.521 - Application for Open Cargo Policy, Form MA-301.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Application for Open Cargo Policy, Form MA-301. 308.521... RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.521 Application for Open Cargo Policy, Form MA-301. The standard form of application for a War Risk Open Cargo Policy...

  13. 46 CFR 308.524 - Application for cancellation of Open Cargo Policy, Form MA-304.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Application for cancellation of Open Cargo Policy, Form... § 308.524 Application for cancellation of Open Cargo Policy, Form MA-304. The standard form of application for cancellation of an Open Cargo Policy Form MA-304 may be obtained from the American War Risk...

  14. 46 CFR 308.523 - Application for revision of Open Cargo Policy, Form MA-303.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Application for revision of Open Cargo Policy, Form MA... Application for revision of Open Cargo Policy, Form MA-303. An application for the revision of an Open Cargo Policy shall be filed in duplicate with the Underwriting Agent on a form which may be obtained from the...

  15. 46 CFR 308.529 - Surety Bond B, Form MA-309.

    Science.gov (United States)

    2010-10-01

    ... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.529 Surety Bond B, Form MA-309. An Assured who elects to substitute a surety bond for a collateral deposit fund shall submit Form MA-309...

  16. Physician-Patient Communication about Dietary Supplements

    Science.gov (United States)

    Tarn, Derjung M.; Paterniti, Debora A.; Good, Jeffrey S.; Coulter, Ian D.; Galliher, James M.; Kravitz, Richard L.; Karlamangla, Arun; Wenger, Neil S.

    2013-01-01

    Objective Describe the content and frequency of provider-patient dietary supplement discussions during primary care office visits. Methods Inductive content analysis of 1477 transcribed audio-recorded office visits to 102 primary care providers was combined with patient and provider surveys. Encounters were collected in Los Angeles, California (2009–2010), geographically-diverse practice settings across the United States (2004–2005), and Sacramento, CA (1998–1999). Results Providers discussed 738 dietary supplements during encounters with 357 patients (24.2% of all encounters in the data). They mentioned: 1) reason for taking the supplement for 46.5% of dietary supplements; 2) how to take the supplement for 28.2%; 3) potential risks for 17.3%; 4) supplement effectiveness for 16.7%; and 5) supplement cost or affordability for 4.2%. Of these five topics, a mean of 1.13 (SD=1.2) topics were discussed for each supplement. More topics were reviewed for non-vitamin non-mineral supplements (mean 1.47 (SD=1.2)) than for vitamin/mineral supplements (mean 0.99 (SD=1.1); psupplements are occurring, it is clear that more discussion might be needed to inform patient decisions about supplement use. Practice Implication Physicians could more frequently address topics that may influence patient dietary supplement use, such as the risks, effectiveness, and costs of supplements. PMID:23466249

  17. Laboratory Animal Welfare Supplement IV.

    Science.gov (United States)

    Gluckstein, Fritz P., Comp.

    This document is the fourth supplement to a 1984 bibliography on laboratory animal welfare. Items presented were selected because they represent some of the most significant of those providing recent information or because they were considered useful. The period covered is October, 1986 through October, 1987. Monographs, conference proceedings,…

  18. BIBLIOGRAPHY ON ACHIEVEMENT. SUPPLEMENT I.

    Science.gov (United States)

    Harvard Univ., Cambridge, MA. Graduate School of Education.

    THIS BIBLIOGRAPHY SUPPLEMENT LISTS MATERIALS ON VARIOUS ASPECTS OF ACHIEVEMENT. APPROXIMATELY 60 REFERENCES ARE PROVIDED TO DOCUMENTS DATING FROM 1961 TO 1966. JOURNALS, BOOKS, AND REPORT MATERIALS ARE LISTED. SUBJECT AREAS INCLUDED ARE ACHIEVEMENT LEVEL, ACADEMIC ACHIEVEMENT, ACHIEVEMENT MOTIVATION, UNDERACHIEVERS, PROBABILITY ESTIMATES, AND…

  19. CHILD DEVELOPMENT BIBLIOGRAPHY. SUPPLEMENT I.

    Science.gov (United States)

    Harvard Univ., Cambridge, MA. Graduate School of Education.

    THIS BIBLIOGRAPHY SUPPLEMENT LISTS MATERIAL ON VARIOUS ASPECTS OF CHILD DEVELOPMENT. APPROXIMATELY 90 UNANNOTATED REFERENCES ARE PROVIDED TO DOCUMENTS DATING FROM 1956 TO 1966. JOURNALS, BOOKS, AND REPORT MATERIALS ARE LISTED. SUBJECT AREAS INCLUDED ARE BEHAVIOR TESTS, CONDITIONING, MATERNAL REACTIONS, GRADE PREDICTABILITY, EXPERIMENTAL STUDIES,…

  20. Understanding the Supplemental Instruction Leader

    Science.gov (United States)

    James, Adrian; Moore, Lori

    2018-01-01

    This article explored the learning styles and leadership styles of Supplemental Instruction (SI) leaders at Texas A&M University, and the impact of those preferences on recurring attendance to their sessions. The Learning Style Inventory, the Multifactor Leadership Questionnaire, and a demographic instrument were administered to SI leaders…

  1. Muscle Mass and Weight Gain Nutritional Supplements

    Science.gov (United States)

    Campbell, Bill

    There are numerous sports supplements available that claim to increase lean body mass. However, for these sports supplements to exert any favorable changes in lean body mass, they must influence those factors regulating skeletal muscle hypertrophy (i.e., satellite cell activity, gene transcription, protein translation). If a given sports supplement does favorably influence one of these regulatory factors, the result is a positive net protein balance (in which protein synthesis exceeds protein breakdown). Sports supplement categories aimed at eliciting a positive net protein balance include anabolic hormone enhancers, nutrient timing pre- and postexercise workout supplements, anticatabolic supplements, and nitric oxide boosters. Of all the sports supplements available, only a few have been subject to multiple clinical trials with repeated favorable outcomes relative to increasing lean body mass. This chapter focuses on these supplements and others that have a sound theoretical rationale in relation to increasing lean body mass.

  2. Calcium Supplements: Do Men Need Them Too?

    Science.gov (United States)

    ... Lifestyle Nutrition and healthy eating Should men take calcium supplements? Answers from Katherine Zeratsky, R.D., L. ... Most healthy men don't need to take calcium supplements. Calcium is important for men for optimal ...

  3. Anthocyanin analyses of Vaccinium fruit dietary supplements

    Science.gov (United States)

    Vaccinium fruit ingredients within dietary supplements were identified by comparisons with anthocyanin analyses of known Vaccinium profiles (demonstration of anthocyanin fingerprinting). Available Vaccinium supplements were purchased and analyzed; their anthocyanin profiles (based on HPLC separation...

  4. Herbal remedies and supplements for weight loss

    Science.gov (United States)

    Weight loss - herbal remedies and supplements; Obesity - herbal remedies; Overweight - herbal remedies ... health care provider. Nearly all over-the-counter supplements with claims of weight-loss properties contain some ...

  5. Adverse Effects of Nutraceuticals and Dietary Supplements.

    Science.gov (United States)

    Ronis, Martin J J; Pedersen, Kim B; Watt, James

    2018-01-06

    Over 70% of Americans take some form of dietary supplement every day, and the supplement industry is currently big business, with a gross of over $28 billion. However, unlike either foods or drugs, supplements do not need to be registered or approved by the US Food and Drug Administration (FDA) prior to production or sales. Under the Dietary Supplement Health and Education Act of 1994, the FDA is restricted to adverse report monitoring postmarketing. Despite widespread consumption, there is limited evidence of health benefits related to nutraceutical or supplement use in well-nourished adults. In contrast, a small number of these products have the potential to produce significant toxicity. In addition, patients often do not disclose supplement use to their physicians. Therefore, the risk of adverse drug-supplement interactions is significant. An overview of the major supplement and nutraceutical classes is presented here, together with known toxic effects and the potential for drug interactions.

  6. Determinants of compliance to iron supplementation among ...

    African Journals Online (AJOL)

    2014-01-28

    Jan 28, 2014 ... practice of routine iron supplementation in pregnancy. The major problem with .... elemental iron and 350 μg of folic acid per tablet. Definition of ..... Determinants of adherence to iron/folate supplementation during pregnancy.

  7. Dietary Supplements for Exercise and Athletic Performance

    Science.gov (United States)

    ... protein. If needed, protein supplements and protein-fortified food and beverage products can help you get enough protein. Sports- ... protein. If needed, protein supplements and protein-fortified food and beverage products can help you get enough protein. Sports- ...

  8. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    Energy Technology Data Exchange (ETDEWEB)

    Rathbone, Bruce A.

    2010-04-01

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at the U.S. Department of Energy (DOE) Hanford site. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with requirements of 10 CFR 835, the DOE Laboratory Accreditation Program, the DOE Richland Operations Office, DOE Office of River Protection, DOE Pacific Northwest Office of Science, and Hanford’s DOE contractors. The dosimetry system is operated by the Pacific Northwest National Laboratory (PNNL) Hanford External Dosimetry Program which provides dosimetry services to PNNL and all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since its inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. The first revision to be released through PNNL’s Electronic Records & Information Capture Architecture database was designated Revision 0. Revision numbers that are whole numbers reflect major revisions typically involving significant changes to all chapters in the document. Revision

  9. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    Energy Technology Data Exchange (ETDEWEB)

    Rathbone, Bruce A.

    2011-04-04

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at the U.S. Department of Energy (DOE) Hanford site. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with requirements of 10 CFR 835, the DOE Laboratory Accreditation Program, the DOE Richland Operations Office, DOE Office of River Protection, DOE Pacific Northwest Office of Science, and Hanford’s DOE contractors. The dosimetry system is operated by the Pacific Northwest National Laboratory (PNNL) Hanford External Dosimetry Program which provides dosimetry services to PNNL and all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since its inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. The first revision to be released through PNNL’s Electronic Records & Information Capture Architecture database was designated Revision 0. Revision numbers that are whole numbers reflect major revisions typically involving significant changes to all chapters in the document. Revision

  10. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    International Nuclear Information System (INIS)

    Rathbone, Bruce A.

    2007-01-01

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at Hanford. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with 10 CFR 835, DOELAP, DOE-RL, ORP, PNSO, and Hanford contractor requirements. The dosimetry system is operated by PNNL's Hanford External Dosimetry Program (HEDP) which provides dosimetry services to all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee (HPDAC) which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. Rev. 0 marks the first revision to be released through PNNL's Electronic Records and Information Capture Architecture (ERICA) database. Revision numbers that are whole numbers reflect major revisions typically involving changes to all chapters in the document. Revision numbers that include a decimal fraction reflect minor revisions, usually restricted to selected chapters or selected pages in the document. Revision Log: Rev. 0 (2/25/2005) Major revision and expansion. Rev. 0.1 (3/12/2007) Minor

  11. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    Energy Technology Data Exchange (ETDEWEB)

    Rathbone, Bruce A.

    2007-03-12

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at Hanford. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with 10 CFR 835, DOELAP, DOE-RL, ORP, PNSO, and Hanford contractor requirements. The dosimetry system is operated by PNNL’s Hanford External Dosimetry Program (HEDP) which provides dosimetry services to all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee (HPDAC) which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. Rev. 0 marks the first revision to be released through PNNL’s Electronic Records & Information Capture Architecture (ERICA) database. Revision numbers that are whole numbers reflect major revisions typically involving changes to all chapters in the document. Revision numbers that include a decimal fraction reflect minor revisions, usually restricted to selected chapters or selected pages in the document. Revision Log: Rev. 0 (2/25/2005) Major revision and expansion. Rev. 0.1 (3/12/2007) Minor

  12. 40 CFR 141.809 - Supplemental treatment.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Supplemental treatment. 141.809... treatment. (a) Any supplemental drinking water treatment units installed onboard existing or new aircraft... the manufacturer's plans and specifications and FAA requirements. (b) Water supplemental treatment and...

  13. 43 CFR 7.32 - Supplemental definitions.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Supplemental definitions. 7.32 Section 7... RESOURCES Department of the Interior Supplemental Regulations § 7.32 Supplemental definitions. For purposes of this subpart, the following definitions will be used: (a) Site of religious or cultural importance...

  14. Weakly distributive modules. Applications to supplement submodules

    Indian Academy of Sciences (India)

    Abstract. In this paper, we define and study weakly distributive modules as a proper generalization of distributive modules. We prove that, weakly distributive supplemented modules are amply supplemented. In a weakly distributive supplemented module every submodule has a unique coclosure. This generalizes a result of ...

  15. 22 CFR 71.12 - Dietary supplements.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Dietary supplements. 71.12 Section 71.12... Incarcerated Abroad § 71.12 Dietary supplements. (a) Eligibility criteria. A prisoner is considered eligible for the dietary supplement program under the following general criteria: (1) An evaluation by a...

  16. 47 CFR 61.86 - Supplements.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Supplements. 61.86 Section 61.86... Rules for Tariff Publications of Dominant and Nondominant Carriers § 61.86 Supplements. A carrier may not file a supplement except to suspend or cancel a tariff publication, or to defer the effective date...

  17. 20 CFR 226.16 - Supplemental annuity.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Supplemental annuity. 226.16 Section 226.16... EMPLOYEE, SPOUSE, AND DIVORCED SPOUSE ANNUITIES Computing an Employee Annuity § 226.16 Supplemental annuity. A supplemental annuity is payable in addition to tiers I and II and the vested dual benefit to an...

  18. Convective removal of the Tibetan Plateau mantle lithosphere by 26 Ma

    Science.gov (United States)

    Lu, Haijian; Tian, Xiaobo; Yun, Kun; Li, Haibing

    2018-04-01

    During the late Oligocene-early Miocene there were several major geological events in and around the Tibetan Plateau (TP). First, crustal shortening deformation ceased completely within the TP before 25 Ma and instead adakitic rocks and potassic-ultrapotassic volcanics were emplaced in the Lhasa terrane since 26-25 Ma. Several recent paleoelevation reconstructions suggest an Oligocene-early Miocene uplift of 1500-3000 m for the Qiangtang (QT) and Songpan-Ganzi (SG) terranes, although the exact timing is unclear. As a possible response to this uplift, significant desertification occurred in the vicinity of the TP at 26-22 Ma, and convergence between India and Eurasia slowed considerably at 26-20 Ma. Subsequently, E-W extension was initiated no later than 18 Ma in the Lhasa and QT terranes. In contrast, the tectonic deformation around the TP was dominated by radial expansion of shortening deformation since 25-22 Ma. The plateau-wide near-synchroneity of these events calls for an internally consistent model which can be best described as convective removal of the lower mantle lithosphere. Geophysical and petrochemical evidence further confirms that this extensive removal occurred beneath the QT and SG terranes. The present review concludes that, other than plate boundary stress, the internal stress within the TP lithosphere could have contributed to rapid wholesale uplift and a series of concomitant tectonic events, accompanied by major aridification, since 26 Ma.

  19. Echt und modern? Diskurse über Männlichkeit

    Directory of Open Access Journals (Sweden)

    Florian Kahofer

    2014-09-01

    Full Text Available Der vorliegende Artikel befasst sich mit Repräsentationen von Männlichkeit im österreichischen Lifestyle-Magazin für Männer Wiener. Durch eine korpusbasierte Diskursanalyse wird ein umfassendes Korpus aller Ausgaben des Wieners von Anfang 2002 bis Ende 2012 untersucht. Auf theoretischer Ebene wird dabei eine Verbindung von Kritischer Männlichkeitsforschung (KMF und Feministisch Kritischer Diskursanalyse (FCDA unternommen. Es werden aktuelle Veröffentlichungen zu Kritischer Diskursanalyse und Männlichkeit vorgestellt und diskutiert. Durch den Einsatz einer Konkordanzsoftware werden Konkordanzen des Nomens MANN analysiert. Diese werden allerdings insofern eingeschränkt betrachtet, als nur Nominationen in der Form der häufigsten Adjektiv-Konstruktionen untersucht werden. Die Ergebnisse zeigen, dass neben den Diskursen über Krise und Neue Männlichkeit Themen wie Alter, Körper oder Beziehung auftauchen. Männlichkeit wird als ambivalent und vielfältig dargestellt. Deutungskämpfe um Männlichkeit lassen sich ausmachen.

  20. Sr isotope geochemistry of voluminous acidic pyroclastics erupted at 1-3 Ma in Northeast Japan

    International Nuclear Information System (INIS)

    Shirahase, Teruo; Tamanyu, Shiro; Togashi, Shigeko

    1989-01-01

    Sr isotope ratios are analyzed for voluminous acidic pyroclastics erupted at 1 - 3 Ma in five areas on the volcanic front of Northeast Japan. The initial values of 87 Sr/ 86 Sr ratios range from 0.7040 to 0.7055. There is no significant difference in ratios between 1 - 3 Ma acidic pyroclastics and 0 - 1 Ma andesitic volcanics in each area in spite of differences in age and in mean SiO 2 content. On the other hand, the ratios in both of 1 - 3 Ma and 0 - 1 Ma volcanics vary along arc in the same manner. The changes of Sr and Rb contents in each area are consistent with systematic changes by fractional crystallization. The low 87 Sr/ 86 Sr ratios and chemistry suggest that 1 - 3 Ma acidic pyroclastics of Northeast Japan formed by a high degree of fractional crystallization from basic magma which is common in genesis with young andesitic volcanism. The mechanisms of the formation of the basic magma and the character of mantle source in each area have not changed for the past 3 Ma. Degrees of fractional crystallization changed with changes of the tectonic condition of shallow magma chamber from a weak horizontal compression stress field to a strong one. (author)

  1. Antioxidative effects in vivo and colonization of Lactobacillus plantarum MA2 in the murine intestinal tract.

    Science.gov (United States)

    Tang, Wei; Xing, Zhuqing; Hu, Wei; Li, Chao; Wang, Jinju; Wang, Yanping

    2016-08-01

    Lactobacillus plantarum MA2 was isolated from traditional Chinese Tibet kefir grains, which possess several excellent properties and functions. We previously demonstrated the antioxidant activities of this bacterium in vitro. However, the maintenance and survival of L. plantarum MA2 inside the murine intestinal tract, where it exerts its probiotic properties, and whether its effects are elicited directly on the host remain unknown. Therefore, this study investigated the mechanisms of L. plantarum MA2 in aging mice following D-galactose administration. The levels of malondialdehyde decreased significantly in the L. plantarum MA2 groups after oral ingestion compared to the D-galactose model group, and total antioxidant capacity and glutathione peroxidase and superoxide dismutase activities increased significantly in the serum and liver. We combined fluorescein isothiocyanate labeling and green fluorescent protein expression to dynamically monitor the colonization and distribution of L. plantarum MA2 in the murine intestinal tract. The results indicated that L. plantarum MA2 was detected in the ileum, colon, and feces after single and continuous oral administration at day 21 and was maintained at 10(4)-10(5) CFU/g. These results suggest that L. plantarum MA2 colonizes and survives in the murine intestinal tract to exert its antioxidative effects.

  2. Vitamin supplementation for preventing miscarriage.

    Science.gov (United States)

    Balogun, Olukunmi O; da Silva Lopes, Katharina; Ota, Erika; Takemoto, Yo; Rumbold, Alice; Takegata, Mizuki; Mori, Rintaro

    2016-05-06

    Miscarriage is a common complication of pregnancy that can be caused by a wide range of factors. Poor dietary intake of vitamins has been associated with an increased risk of miscarriage, therefore supplementing women with vitamins either prior to or in early pregnancy may help prevent miscarriage. The objectives of this review were to determine the effectiveness and safety of any vitamin supplementation, on the risk of spontaneous miscarriage. We searched the Cochrane Pregnancy and Childbirth Group Trials Register (6 November 2015) and reference lists of retrieved studies. All randomised and quasi-randomised trials comparing supplementation during pregnancy with one or more vitamins with either placebo, other vitamins, no vitamins or other interventions. We have included supplementation that started prior to conception, periconceptionally or in early pregnancy (less than 20 weeks' gestation). Three review authors independently assessed trials for inclusion, extracted data and assessed trial quality. We assessed the quality of the evidence using the GRADE approach. The quality of evidence is included for numerical results of outcomes included in the 'Summary of findings' tables. We included a total of 40 trials (involving 276,820 women and 278,413 pregnancies) assessing supplementation with any vitamin(s) starting prior to 20 weeks' gestation and reporting at least one primary outcome that was eligible for the review. Eight trials were cluster-randomised and contributed data for 217,726 women and 219,267 pregnancies in total.Approximately half of the included trials were assessed to have a low risk of bias for both random sequence generation and adequate concealment of participants to treatment and control groups. Vitamin C supplementation There was no difference in the risk of total fetal loss (risk ratio (RR) 1.14, 95% confidence interval (CI) 0.92 to 1.40, seven trials, 18,949 women; high-quality evidence); early or late miscarriage (RR 0.90, 95% CI 0.65 to 1

  3. Studiju programmas direktora informatīvā sistēma

    OpenAIRE

    Gūtmanis, Matīss

    2012-01-01

    Šajā kvalifikācijas darbā tiek izstrādāta atbalsta sistēma studiju programmas direktoram pamata informācijas glabāšanai. Sistēma tiek plānota kā tīmekļa lietotne, kas ir brīvi pieejama ikvienam. Lietotne ir izstrādāta izmantojot JAVA, HTML, JavaScript, MySQL tehnoloģijas. Sistēma paredzēta Latvijas Universitātes Datorikas Fakultātes programmu direktoriem.

  4. Hypersomnia as presenting symptom of anti-Ma2-associated encephalitis: case study.

    Science.gov (United States)

    Rojas-Marcos, Iñigo; Graus, Francesc; Sanz, Gema; Robledo, Arturo; Diaz-Espejo, Carlos

    2007-01-01

    We describe a patient who presented with excessive daytime sleepiness (EDS) and was eventually diagnosed with anti-Ma2 encephalitis. Neurological examination disclosed somnolence, left palpebral ptosis, and vertical gaze paresis. A brain MRI showed high signal intensity in the hypothalamus and each hippocampus. Ma2 antibodies were found in the patient's serum, and fiberbronchoscopy disclosed a lung carcinoma. After three months of steroid treatment, the results of the patient's neurological exam became normal. We conclude that anti-Ma2 encephalitis may present with mostly isolated EDS and that it may respond to steroids despite old age and the presence of an untreated lung cancer.

  5. Impact of M&A on the Employment in Japanese Companies

    OpenAIRE

    Hiroyuki Taguchi; Taichi Yanagawa; Masashi Harita

    2012-01-01

    With utilizing Financial Statements Statistics of Corporation by Industry, we analyzed the impact of M&A on the employment in Japanese companies. In this study, the impact of M&A on the employment was extracted by developing panel data for fiscal year 1995 to 2008 targeting 9,880 sample companies including 3,697 cases of M&A to estimate a labor demand model. Major findings of the study are described below. First, dynamically positive effect was confirmed mainly in the manufacturing industry a...

  6. RuleMaDrone: A Web-Interface to Visualise Space Usage Rules for Drones

    OpenAIRE

    Trippaers, Aäron

    2015-01-01

    RuleMaDrone, an application developed within this thesis, is presented as a solution to communicate the rules and regulations to drone operators. To provide the solution a framework for drone safety was designed which consists of the rules and regulations, the drone properties and the environmental factors. RuleMaDrone is developed with this framework and thus will provide drone operators with an application which they can use to find a safe and legal fly zone. RuleMaDrone u...

  7. Caractérisation des systemes de production à base de maïs dans ...

    African Journals Online (AJOL)

    La présente recherche vise à caractériser les systèmes de production à base de maïs au Bénin pour un appui-conseil ciblé aux producteurs de maïs. La base de sondage est la base de données du sous-projet "Centre National de Spécialisation sur le Maïs", exécuté par l'Institut National des Recherches Agricoles du Bénin ...

  8. Neutron radiographic characteristics of MA-ND type (allyl-diglycol-carbonate) nuclear track detectors

    Energy Technology Data Exchange (ETDEWEB)

    Ilic, R.; Rant, J.; Humar, M.; Somogyi, G.; Hunyadi, I.

    1986-01-01

    Neutron radiographic properties of recently developed new nuclear track detectors (MA-ND/..cap alpha.., MA-ND/p and MA-ND/p1), manufactured from allyl diglycol carbonate, were studied. It was found that the quality of radiographic image has an optimum at a removed layer thickness of about 0.8 ..mu..m. The image obtained under this condition is characterized by high detection sensitivity to neutrons (approx. 8.10/sup -3/ tracks/nsub(th) when using B converter) and by excellent inherent unsharpness (approx. 5 ..mu..m) as well as high image contrast (maximum value of net optical density is approx. 1.4).

  9. Hanford External Dosimetry Technical Basis Manual PNL-MA-842

    Energy Technology Data Exchange (ETDEWEB)

    Rathbone, Bruce A.

    2010-01-01

    The Hanford External Dosimetry Technical Basis Manual PNL-MA-842 documents the design and implementation of the external dosimetry system used at Hanford. The manual describes the dosimeter design, processing protocols, dose calculation methodology, radiation fields encountered, dosimeter response characteristics, limitations of dosimeter design under field conditions, and makes recommendations for effective use of the dosimeters in the field. The manual describes the technical basis for the dosimetry system in a manner intended to help ensure defensibility of the dose of record at Hanford and to demonstrate compliance with 10 CFR 835, DOELAP, DOE-RL, ORP, PNSO, and Hanford contractor requirements. The dosimetry system is operated by PNNL’s Hanford External Dosimetry Program (HEDP) which provides dosimetry services to all Hanford contractors. The primary users of this manual are DOE and DOE contractors at Hanford using the dosimetry services of PNNL. Development and maintenance of this manual is funded directly by DOE and DOE contractors. Its contents have been reviewed and approved by DOE and DOE contractors at Hanford through the Hanford Personnel Dosimetry Advisory Committee (HPDAC) which is chartered and chaired by DOE-RL and serves as means of coordinating dosimetry practices across contractors at Hanford. This manual was established in 1996. Since its inception, it has been revised many times and maintained by PNNL as a controlled document with controlled distribution. The first revision to be released through PNNL’s Electronic Records & Information Capture Architecture (ERICA) database was designated Revision 0. Revision numbers that are whole numbers reflect major revisions typically involving significant changes to all chapters in the document. Revision numbers that include a decimal fraction reflect minor revisions, usually restricted to selected chapters or selected pages in the document. Maintenance and distribution of controlled hard copies of the

  10. Particle Suspension Mechanisms - Supplemental Material

    Energy Technology Data Exchange (ETDEWEB)

    Dillon, M B

    2011-03-03

    This supplemental material provides a brief introduction to particle suspension mechanisms that cause exfoliated skin cells to become and remain airborne. The material presented here provides additional context to the primary manuscript and serves as background for designing possible future studies to assess the impact of skin cells as a source of infectious aerosols. This introduction is not intended to be comprehensive and interested readers are encouraged to consult the references cited.

  11. Nutritional supplementation for Alzheimer's disease?

    Science.gov (United States)

    Shea, Thomas B; Remington, Ruth

    2015-03-01

    Evidence for the benefit of nutrition in Alzheimer's disease continues to accumulate. Many studies with individual vitamins or supplements show marginal, if any, benefit. However, new findings with combinatorial formulations demonstrate improvement in cognitive performance and behavioral difficulties that accompany Alzheimer's disease. Herein, we review some of the most recent clinical advances and summarize supportive preclinical studies. We present novel positive effects on Alzheimer's disease derived from diet, trace elements, vitamins and supplements. We discuss the inherent difficulty in conducting nutritional studies because of the variance in participants' nutritional history, versus pharmacological interventions in which participants are naive to the intervention. We examine the evidence that epigenetics play a role in Alzheimer's disease and how nutritional intervention can modify the key epigenetic events to maintain or improve cognitive performance. Overall consideration of the most recent collective evidence suggests that the optimal approach for Alzheimer's disease would seem to combine early, multicomponent nutritional approaches (a Mediterranean-style diet, multivitamins and key combinatorial supplements), along with lifestyle modifications such as social activity and mental and physical exercise, with ultimate addition of pharmacological agents when warranted.

  12. Why US children use dietary supplements

    Science.gov (United States)

    Bailey, Regan L.; Gahche, Jaime J.; Thomas, Paul R.; Dwyer, Johanna T.

    2013-01-01

    Background: Dietary supplements are used by one-third of children. We examined motivations for supplement use in children, the types of products used by motivations, and the role of physicians and health care practitioners in guiding choices about supplements. Methods: We examined motivations for dietary supplement use reported for children (from birth to 19 y of age; n = 8,245) using the National Health and Nutrition Examination Survey 2007–2010. Results: Dietary supplements were used by 31% of children; many different reasons were given as follows: to “improve overall health” (41%), to “maintain health” (37%), for “supplementing the diet” (23%), to “prevent health problems” (20%), and to “boost immunity” (14%). Most children (~90%) who use dietary supplements use a multivitamin–mineral or multivitamin product. Supplement users tend to be non-Hispanic white, have higher family incomes, report more physical activity, and have health insurance. Only a small group of supplements used by children (15%) were based on the recommendation of a physician or other health care provider. Conclusion: Most supplements used by children are not under the recommendation of a health care provider. The most common reasons for use of supplements in children are for health promotion, yet little scientific data support this notion in nutrient-replete children. PMID:24002333

  13. Assessing patients' attitudes towards dietary supplements.

    Science.gov (United States)

    Wierzejska, Regina; Jarosz, Mirosław; Siuba, Magdalena; Rambuszek, Michał

    2014-01-01

    There is currently many over the counter products on the market that exert nutritional or physiological effects on the human body. The differences between dietary supplements and non-prescription drugs are however poorly understood by the average consumer and may thus affect their expectations as to the desired effect produced on the body. To evaluate patients' knowledge and attitudes towards dietary supplements as compared to non-prescription drugs. Subjects were 335 patients of the Mazowiecki Voivodeship Hospital in Warsaw, Poland. The data were collected from a face-to-face interview using a single and multiple choice questionnaire with 10 questions on dietary supplements. Statistical analysis used the Chi-square (χ2) test. The majority of respondents were found to be familiar with the term 'dietary supplements', but had difficulties in classifying these products into appropriate categories. Over 55% do not consider dietary supplements to be foodstuffs and more than 40% considered such products to be drugs. Most respondents thought that the main purpose of taking dietary supplements is to improve nutrition, but over one third expected them to also treat disease. Over 70% declared taking notice to which category the non-prescription products they bought belongs to ie. whether non-prescription drugs (medicinal products) or dietary supplements. Many patients mistakenly believe that dietary supplements are drugs and can be used to treat disease and health disorders. dietary supplements, opinion on dietary supplements, nutrition, dietary supplement vs. medicinal product.

  14. EnviroAtlas - New Bedford, MA - Meter-Scale Urban Land Cover (MULC) Data (2010)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The New Bedford, MA Meter-Scale Urban Land Cover (MULC) data were generated from United States Department of Agriculture (USDA) National Agricultural Imagery Program...

  15. Playwriting as a medium for conscientization: a study of an M.A. ...

    African Journals Online (AJOL)

    Playwriting as a medium for conscientization: a study of an M.A. thesis play on ... For the purpose of this research effort, an imaginary academic environment ... university disciplinary committees- the Professional Ethics Committee (PEC), as ...

  16. Comparison of TCeMA and TDMA for Inter-Satellite Communications using OPNET Simulation

    Science.gov (United States)

    Hain, Regina Rosales; Ramanathan, Ram; Bergamo, Marcos; Wallett, Thomas M.

    2003-01-01

    A robust data link protocol, enabling unique physical and MAC layer technologies and sub-network level protocols, is needed in order to take advantage of the full potential of using both TDMA and CDMA in a satellite communication network. A novel MAC layer protocol, TDMA with CDMA-encoding multiple access (TCeMA) integrated with null-steered digital beam-forming spatial multiplexing, is investigated to support flexible spacecraft communications. Abstract models of the TCeMA and TDMA processes are developed in OPNFiT and a comparison of the performances of TCeMA and TDMA in a satellite network simulation are made. TCeMA provides the better connectivity and capacity with respect to TDMA for satellite communication traffic.

  17. Design of an upgradeable 45-100 mA RFQ accelerator for FAIR

    Science.gov (United States)

    Zhang, Chuan; Schempp, Alwin

    2009-10-01

    A 325 MHz, 35 mA, 3 MeV Radio-Frequency Quadrupole (RFQ) accelerator will be operated as the first accelerating structure of the proton linac injector for the newly planned international science center Facility for Antiproton and Ion Research (FAIR) at GSI, Germany. In previous design studies, two high beam intensities, 70 and 100 mA, were used. Most recently, the design intensity has been changed to 45 mA, which is closer to the operational value. Taking advantage of the so-called New Four-Section Procedure, a new design, which is upgradable from 45 to 100 mA, has been developed for the FAIR proton RFQ. Besides the upgradability analyses, robustness studies of the new design to spatial displacements of the input beam and field errors are presented as well.

  18. "Ma sinna istutaks need lilled punased..." : [luuletused] / [Ptshelovodova, Nadezhda] Muš Nadii ; tlk. Arvo Valton

    Index Scriptorium Estoniae

    Muš Nadii, pseud., 1976-

    2006-01-01

    Sisu: "Ma sinna istutaks need lilled punased..." ; "Ei kõik hinged tõuse taevasse..." ; Kuum öö ; Kas tunned ; Ojamaa ; Magnoolia ; 24.02.2005 ; Päike vaatab tagasi. Luuletused paralleelselt udmurdi ja eesti keeles

  19. Klasifikasi Kecamatan Berdasarkan Nilai Akhir SMA/MA di Kabupaten Aceh Selatan Menggunakan Analisis Diskriminan

    Directory of Open Access Journals (Sweden)

    Fitriana A.R.

    2015-11-01

    Full Text Available Analisis diskriminan merupakan bagian dari analisis peubah ganda. Analisis diskriminan digunakan untuk memodelkan variabel tak bebas yang bersifat kualitatif dengan variabel bebas yang bersifat kuantitatif. Pada penelitian ini, analisis diskriminan lebih dari dua kelompok diterapkan pada data nilai akhir SMA/MA di Kabupaten Aceh Selatan yang bertujuan untuk mendapatkan model untuk pengklasifikasian kecamatan. Pengklasifikasian ini bertujuan untuk melihat perbedaan kualitas siswa SMA/MA yang berada di masing-masing kecamatan Kabupaten Aceh Selatan berdasarkan data nilai akhir. Variabel tak bebas yang digunakan berupa klasifikasi kecamatan berdasarkan rata-rata jumlah nilai akhir SMA/MA yang berada di masing-masing kecamatan yang dibentuk dengan K-Means Cluster. Sedangkan variabel bebas yang digunakan adalah data rata-rata nilai akhir SMA/MA untuk setiap mata pelajaran yang diujiankan pada masing-masing jurusan setiap kecamatan. Model yang didapatkan adalah dua model diskriminan untuk jurusan IPA dan IPS.

  20. The Mesoscale Science of the Matter-Radiation Interactions in Extremes (MaRIE) project

    Energy Technology Data Exchange (ETDEWEB)

    Kippen, Karen Elizabeth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Montoya, Donald Raymond [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-08-17

    The National Nuclear Security Administration (NNSA) requires the ability to understand and test how material structures, defects, and interfaces determine performance in extreme environments such as in nuclear weapons. To do this, MaRIE will be an x-ray source that is laser-like and brilliant with very fl exible and fast pulses to see at weapons-relevant time scales, and with high enough energy to study critical materials. The Department of Energy (DOE) has determined there is a mission need for MaRIE to deliver this capability. MaRIE can use some of the existing infrastructure of the Los Alamos Neutron Science Center (LANSCE) and its accelerator capability. MaRIE will be built as a strategic partnership of DOE national laboratories and university collaborators.

  1. Contact Aligner 1 (Front and Back Side): Suss Microtec MA6

    Data.gov (United States)

    Federal Laboratory Consortium — Description:CORAL Name: SussMA6This system utilizes 1X contact lithography to transfer photomask patterns onto substrates Specifications / Capabilities:UV broadmand...

  2. Design of an upgradeable 45-100 mA RFQ accelerator for FAIR

    International Nuclear Information System (INIS)

    Zhang Chuan; Schempp, Alwin

    2009-01-01

    A 325 MHz, 35 mA, 3 MeV Radio-Frequency Quadrupole (RFQ) accelerator will be operated as the first accelerating structure of the proton linac injector for the newly planned international science center Facility for Antiproton and Ion Research (FAIR) at GSI, Germany. In previous design studies, two high beam intensities, 70 and 100 mA, were used. Most recently, the design intensity has been changed to 45 mA, which is closer to the operational value. Taking advantage of the so-called New Four-Section Procedure, a new design, which is upgradable from 45 to 100 mA, has been developed for the FAIR proton RFQ. Besides the upgradability analyses, robustness studies of the new design to spatial displacements of the input beam and field errors are presented as well.

  3. 46 CFR 308.409 - Standard form of War Risk Builder's Risk Insurance Policy, Form MA-283.

    Science.gov (United States)

    2010-10-01

    ... Policy, Form MA-283. 308.409 Section 308.409 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF... of War Risk Builder's Risk Insurance Policy, Form MA-283. The standard form of War Risk Builder's Risk Insurance Policy, Form MA-283 may be obtained from the American War Risk Agency or MARAD. ...

  4. CoMA, an instrument for the detailed in-situ analysis of collected cometary particulates

    International Nuclear Information System (INIS)

    Kissel, J.; Fechtig, H.; Jessberger, E.K.; Krueger, F.R.; Niemczyk, N.; Schaefer, G.; Zscheeg, H.

    1988-01-01

    The proposal for CoMA, a pulsed time-of-flight SIMS instrument to be flown onboard CRAF to rendezvous with a comet, had been accepted by NASA in October 1986. After several attempts it seems that funding by BMFT for the instrument pre-development phase can be obtained. Apart from that we made first essential progress in producing the primary ion pulses from an indium liquid metal ion source. Those pulses are needed to operate CoMA. (orig.)

  5. Schéma directeur des Systèmes d'information 2012-2016

    OpenAIRE

    Institut National de Recherche Agronomique UAR 0776 Administration du siège

    2012-01-01

    Le schéma directeur des systèmes d’information de l’inra est le premier Schéma directeur dont l’institut se dote dans le champ des systèmes D’information. Il couvre la période 2012‐2016 du contrat d’objectifs Et s’inscrit dans les perspectives scientifiques dressées par le document D’orientation 2010‐2020

  6. Radiation hardening and irradiation testing of in-cell electronics for MA23/APM

    International Nuclear Information System (INIS)

    Friant, A.

    1988-09-01

    We relate briefly the radiation hardening method used to guarantee a gamma resistance of 10 Mrad for the whole electronic equipment associated with the slave arm of MA23 M servomanipulator which will be set up in cell 404 in Marcoule (APM). We describe the radiation testing of electronic devices and of the various subsystems designed by the D. LETI groups involved in the MA23/APM project

  7. Effect of the mechanical processing on the mechanical properties of MA956 alloy. II. Mechanical characterization

    International Nuclear Information System (INIS)

    Chao, J.; Gonzalez-Doncel, G.

    1998-01-01

    The mechanical properties at room and low temperature of MA 956 alloy in some stages of their processing route are evaluated. In this study the influence of crystallographic orientation on plastic deformation and brittle fracture, strongly anisotropic phenomena, is also considered. It is concluded that even though MA 956 alloy was designated for high temperature applications it could be also used for cryogenic temperatures applications. (Author) 8 refs

  8. TRANSFORMASI KURIKULUM PESANTREN: Telaah Pemikiran KH. MA. Sahal Mahfudh dan Nurcholish Madjid

    OpenAIRE

    Mukhlison Effendi; Suradi Suradi

    2016-01-01

    Abstract; Islamic boarding school is an indigenous Indonesia. Some contribution that given in the Islamization process, create a good community literacy and culture are very large. One reason, because there are Islamic boarding school curriculum transformation. Most influential enticement are KH. MA. Sahal Mahfudh and Nurcholish Madjid enticement. To knowing and determine the transformation both of those figures, the researcher take focus of study as: 1) the speculation of KH. MA. Sahal Mahfu...

  9. The HectoMAP Cluster Survey. I. redMaPPer Clusters

    Science.gov (United States)

    Sohn, Jubee; Geller, Margaret J.; Rines, Kenneth J.; Hwang, Ho Seong; Utsumi, Yousuke; Diaferio, Antonaldo

    2018-04-01

    We use the dense HectoMAP redshift survey to explore the properties of 104 redMaPPer cluster candidates. The redMaPPer systems in HectoMAP cover the full range of richness and redshift (0.08 systems included in the Subaru/Hyper Suprime-Cam public data release are bona fide clusters. The median number of spectroscopic members per cluster is ∼20. We include redshifts of 3547 member candidates listed in the redMaPPer catalog whether they are cluster members or not. We evaluate the redMaPPer membership probability spectroscopically. The purity (number of real systems) in redMaPPer exceeds 90% even at the lowest richness. Three massive galaxy clusters (M ∼ 2 × 1013 M ⊙) associated with X-ray emission in the HectoMAP region are not included in the public redMaPPer catalog with λ rich > 20, because they lie outside the cuts for this catalog.

  10. MaGate Simulator: A Simulation Environment for a Decentralized Grid Scheduler

    Science.gov (United States)

    Huang, Ye; Brocco, Amos; Courant, Michele; Hirsbrunner, Beat; Kuonen, Pierre

    This paper presents a simulator for of a decentralized modular grid scheduler named MaGate. MaGate’s design emphasizes scheduler interoperability by providing intelligent scheduling serving the grid community as a whole. Each MaGate scheduler instance is able to deal with dynamic scheduling conditions, with continuously arriving grid jobs. Received jobs are either allocated on local resources, or delegated to other MaGates for remote execution. The proposed MaGate simulator is based on GridSim toolkit and Alea simulator, and abstracts the features and behaviors of complex fundamental grid elements, such as grid jobs, grid resources, and grid users. Simulation of scheduling tasks is supported by a grid network overlay simulator executing distributed ant-based swarm intelligence algorithms to provide services such as group communication and resource discovery. For evaluation, a comparison of behaviors of different collaborative policies among a community of MaGates is provided. Results support the use of the proposed approach as a functional ready grid scheduler simulator.

  11. Periodic modulations controlling Kuznetsov–Ma soliton formation in nonlinear Schrödinger equations

    Energy Technology Data Exchange (ETDEWEB)

    Tiofack, C.G.L., E-mail: glatchio@yahoo.fr [Univ. Lille, CNRS, UMR 8523 – PhLAM – Physique des Lasers Atomes et Molécules, F-59000 Lille (France); Coulibaly, S.; Taki, M. [Univ. Lille, CNRS, UMR 8523 – PhLAM – Physique des Lasers Atomes et Molécules, F-59000 Lille (France); De Bièvre, S.; Dujardin, G. [Univ. Lille, CNRS, UMR 8524 – Laboratoire Paul Painlevé, F-59000 Lille (France); Équipe-Projet Mephysto, INRIA Lille-Nord Europe (France)

    2017-06-28

    We analyze the exact Kuznetsov–Ma soliton solution of the one-dimensional nonlinear Schrödinger equation in the presence of periodic modulations satisfying an integrability condition. We show that, in contrast to the case without modulation, the Kuznetsov–Ma soliton develops multiple compression points whose number, shape and position are controlled both by the intensity of the modulation and by its frequency. In addition, when this modulation frequency is a rational multiple of the natural frequency of the Kuznetsov–Ma soliton, a scenario similar to a nonlinear resonance is obtained: in this case the spatial oscillations of the Kuznetsov–Ma soliton's intensity are periodic. When the ratio of the two frequencies is irrational, the soliton's intensity is a quasiperiodic function. A striking and important result of our analysis is the possibility to suppress any component of the output spectrum of the Kuznetsov–Ma soliton by a judicious choice of the amplitude and frequency of the modulation. - Highlights: • Exact Kuznetsov–Ma soliton solution in presence of periodic coefficients is obtained. • The multiple compression points of the solution are studied. • The quasi-periodicity of the solution is discussed. • The possibility to suppress any component of the spectrum is analyzed.

  12. Correlating The Star Formation Histories Of MaNGA Galaxies With Their Past AGN Activity

    Science.gov (United States)

    Gonzalez Ortiz, Andrea

    2017-01-01

    We investigate active galactic nuclei (AGN) as a primary mechanism affecting star formation in MaNGA galaxies. Using the Pipe3D code, we modeled the stellar population from MaNGA spectra and derived the star formation histories of 53 AGN host galaxies. We seek to compare the star formation histories of the host galaxies of AGN with the ages of their radio lobes to better understand the role of AGN feedback in the star formation histories of MaNGA galaxies. MaNGA (Mapping Nearby Galaxies at APO) is one of the three core programs in the fourth generation Sloan Digital Sky Survey(SDSS). MaNGA will investigate the internal kinematics of nearly 10,000 local galaxies through dithered observations using fiber integral field units (IFUs) that vary in diameter from 12" (19 fibers) to 32" (127 fibers). In this poster, we present initial results on the star formation histories of MaNGA AGN host galaxies. This work was supported by the SDSS Research Experience for Undergraduates program, which is funded by a grant from Sloan Foundation to the Astrophysical Research Consortium.

  13. Evaluation of congruence among dietary supplement use and motivation for supplementation in young, Canadian athletes.

    Science.gov (United States)

    Parnell, Jill A; Wiens, Kristin; Erdman, Kelly Anne

    2015-01-01

    Dietary supplement use is endemic in young athletes; however, it is unclear if their choices are congruent with their motivation for supplementation and the established benefits of the dietary supplements. The aim of this study was to evaluate the relationships between dietary supplement use and self-reported rationale in young athletes. Canadian athletes (n = 567; 11-25 years; 76% club or provincial level, 24% national or higher) completed a questionnaire designed to assess supplementation patterns and motivation for supplementation. Chi square tests examined associations between dietary supplements and self-reported rationale for use. Vitamin and mineral supplements, including vitamin-enriched water, were associated with several health- and performance- related reasons (p performance reasons, as were performance foods (protein powder, sport bars, sport gels, etc.). Plant extracts and fatty acids were primarily associated with health reasons, particularly immune support (p performance rationales and supplementation for common ergogenic aids, however, less so for vitamin and mineral supplements, vitamin-enriched water, and plant extracts. Incongruences were found between fatty acids, protein supplements, vitamin and mineral supplements, vitamin-enriched water, and plant extracts and health motivators for supplementation. Educational interventions are essential to ensure young athletes are using dietary supplements safely and effectively.

  14. Carcass fabrication yields of beef steers supplemented zilpaterol hydrochloride and offered ad libitum or maintenance energy intake.

    Science.gov (United States)

    Schmitz, Angela N; Walter, Lee-Anne J; Nichols, Wade T; Hutcheson, John P; Lawrence, Ty E

    2018-06-04

    An experiment was conducted to evaluate the fabrication yields of carcasses from beef steers supplemented zilpaterol hydrochloride (ZH) and fed at maintenance (MA) or ad libitum (AB) intake levels. Beef steers (n = 56) from a common sire were blocked (n = 28 per block) by terminal growth implant and sorted into pairs by BW. Four pairs (n = 8) were harvested on day 0; the remaining 24 pairs (n = 48) were assigned to a dietary intake level (MA or AB) and days on feed (28 or 56 d). Within pairs of MA or AB intakes, steers harvested on day 56 were randomly assigned to supplementation of ZH (90 mg·d-1 per steer) for 20 d followed by a withdrawal period of 4 d or control (C). Steers (BW = 603.5 ± 48.1 kg) were harvested at a commercial processing facility. After a 24-h chill period, standard USDA grading procedures were used to derive a calculated yield grade and quality grade. Following grading, left carcass sides were transported to the West Texas A&M University Meat Laboratory for fabrication. Each side was fabricated into subprimals to determine individual red meat yield (RMY), trimmable fat yield (TFY), and bone yield (BY). A mixed model was used for analysis; fixed effects included treatment combinations and random effects included block and pairs. Single df contrasts tested day 0 vs. 28, day 0 vs. 56, day 28 vs. 56, MA vs. AB, and C vs. ZH. Yield of chuck eye roll differed (P = 0.05) by days on feed (0 d = 4.14, 28 d = 4.11, 56 d = 4.55%). Similarly, eye of round yield was impacted (P = 0.02) by days on feed (0 d = 1.51, 28 d = 1.37, 56 d = 1.36%). Additionally, brisket yield was altered (P < 0.01) by days on feed (0 d = 4.08, 28 d = 3.56, 56 d = 3.48%) and treatment (C = 3.34, ZH = 3.61%). For remaining subprimals, no differences (P ≥ 0.15) were detected. Furthermore, results indicated that RMY tended (P = 0.07) to differ by treatment (C = 61.35, ZH = 63.67%). Comparatively, TFY was impacted (P = 0.04) by intake (MA = 20.44, AB = 23.33%). Results from this

  15. Fontes de silício no desenvolvimento de plântulas de bananeira 'Maçã' micropropagadas Sources of silicon in the development of micropropagated seedlings of banana 'Maçã'

    Directory of Open Access Journals (Sweden)

    Simone Abreu Asmar

    2011-07-01

    Full Text Available O objetivo deste trabalho foi avaliar o efeito de diferentes fontes de silício durante a fase de enraizamento in vitro de bananeira 'Maçã' por meio de análise fisiológica, fitotécnica e ultraestrutural. Foram utilizados propágulos já estabelecidos in vitro e inoculados em meio MURASHIGE & SKOOG (MS, adicionado de 30g L-1 de sacarose, 1mg L-1 de ANA (ácido naftalenoacético e solidificado com 1,8g L-1 de PhytagelTM. Foram testadas três fontes de silicato acrescidas ao meio MS, silicato de sódio, silicato de potássio e silicato de cálcio, na dosagem de 1g L-1 e o meio MS sem silicato como testemunha. O delineamento experimental foi o inteiramente casualizado, com quinze repetições. Os propágulos foram mantidos por 45 dias em sala de crescimento, sob condições controladas. Verificou-se aumento nos teores de clorofila a, b e total na presença de silicato de cálcio. A suplementação do meio de cultura com silicato de sódio promoveu aumento de comprimento, massa fresca e seca de parte aérea. O silício proporciona adequado desenvolvimento das plântulas.The objective of the research was to evaluate the effect of different sources of silicon during the in vitro rooting phase of 'Maçã' banana tree by means of physiological, phytotechnical and ultrastructural analysis. It was used propagules already established in vitro which were inoculated in MURASHIGE & SKOOG (MS medium, added of 30g L-1 of sucrose, 1mg L-1 of NAA (naphthalene acetic acid and solidified with 1.8g L-1 of PhytagelTM. It was tested three sources of silicate added to MS medium, sodium silicate, potassium silicate and calcium silicate, at a dose of 1g L-1 and MS medium without silicate as a witness. The experimental design was completely randomized with fifteen replicates. The propagules were kept for 45 days in a growth room under controlled conditions. There was an increase in levels of chlorophyll a, b and total in the presence of calcium silicate

  16. Athletes and Supplements: Prevalence and Perspectives.

    Science.gov (United States)

    Garthe, Ina; Maughan, Ronald J

    2018-03-01

    In elite sport, where opponents are evenly matched, small factors can determine the outcome of sporting contests. Not all athletes know the value of making wise nutrition choices, but anything that might give a competitive edge, including dietary supplements, can seem attractive. Between 40% and 100% of athletes typically use supplements, depending on the type of sport, level of competition, and the definition of supplements. However, unless the athlete has a nutrient deficiency, supplementation may not improve performance and may have a detrimental effect on both performance and health. Dietary supplements are classified as a subcategory of food, so manufacturers are not required to provide evidence of product safety and efficacy, nor obtain approval from regulatory bodies before marketing supplements. This creates the potential for health risks, and serious adverse effects have been reported from the use of some dietary supplements. Athletes who compete in sports under an anti-doping code must also realize that supplement use exposes them to a risk of ingesting banned substances or precursors of prohibited substances. Government systems of regulations do not include specific laboratory testing for banned substances according to the WADA list, so a separate regulatory framework to evaluate supplements for their risk of provoking a failed doping test is needed. In the high-performance culture typical of elite sport, athletes may use supplements regardless of possible risks. A discussion around medical, physiological, cultural, and ethical questions may be warranted to ensure that the athlete has the information needed to make an informed choice.

  17. Side effects of creatine supplementation in athletes.

    OpenAIRE

    Francaux, Marc; Poortmans, Jacques R

    2006-01-01

    Context: Allegations about side effects of creatine supplementation by athletes have been published in the popular media and scientific publications. Purpose: To examine the experimental evidence relating to the physiological effects of creatine supplementation. Results: One of the purported effects of oral creatine supplementation is increased muscle mass. A review of the literature reveals a 1.0% to 2.3% increase in body mass, which is attributed to fat-free mass and, more specifically, to ...

  18. Use of Nutrition Supplements for the Elderly

    OpenAIRE

    Tenglerová, Dana

    2014-01-01

    The primary goal of my thesis was to describe the use of food supplements by seniors. Most seniors use medications prescribed by physicians and some of them also use over-the-counter food supplements that are more easily accessible. Seniors, in particular, are susceptible to considering food supplements to be as efficient as medications under the incessant influence of massive advertising on TV and other media, and many of them are willing to spend considerable amounts from their income on su...

  19. Structuring supplemental materials in support of reproducibility

    OpenAIRE

    Greenbaum, Dov; Rozowsky, Joel; Stodden, Victoria; Gerstein, Mark

    2017-01-01

    Supplements are increasingly important to the scientific record, particularly in genomics. However, they are often underutilized. Optimally, supplements should make results findable, accessible, interoperable, and reusable (i.e., ?FAIR?). Moreover, properly off-loading to them the data and detail in a paper could make the main text more readable. We propose a hierarchical organization for supplements, with some parts paralleling and ?shadowing? the main text and other elements branching off f...

  20. Dietary Supplements: Regulatory Challenges and Research Resources

    OpenAIRE

    Johanna T. Dwyer; Paul M. Coates; Michael J. Smith

    2018-01-01

    Many of the scientific and regulatory challenges that exist in research on the safety, quality and efficacy of dietary supplements are common to all countries as the marketplace for them becomes increasingly global. This article summarizes some of the challenges in supplement science and provides a case study of research at the Office of Dietary Supplements at the National Institutes of Health, USA, along with some resources it has developed that are available to all scientists. It includes e...

  1. Nutrition and Supplementation in Soccer

    Science.gov (United States)

    Oliveira, César Chaves; Ferreira, Diogo; Caetano, Carlos; Granja, Diana; Pinto, Ricardo; Mendes, Bruno; Sousa, Mónica

    2017-01-01

    Contemporary elite soccer features increased physical demands during match-play, as well as a larger number of matches per season. Now more than ever, aspects related to performance optimization are highly regarded by both players and soccer coaches. Here, nutrition takes a special role as most elite teams try to provide an adequate diet to guarantee maximum performance while ensuring a faster recovery from matches and training exertions. It is currently known that manipulation and periodization of macronutrients, as well as sound hydration practices, have the potential to interfere with training adaptation and recovery. A careful monitoring of micronutrient status is also relevant to prevent undue fatigue and immune impairment secondary to a deficiency status. Furthermore, the sensible use of evidence-based dietary supplements may also play a role in soccer performance optimization. In this sense, several nutritional recommendations have been issued. This detailed and comprehensive review addresses the most relevant and up-to-date nutritional recommendations for elite soccer players, covering from macro and micronutrients to hydration and selected supplements in different contexts (daily requirements, pre, peri and post training/match and competition). PMID:29910389

  2. Nutrition and Supplementation in Soccer.

    Science.gov (United States)

    Oliveira, César Chaves; Ferreira, Diogo; Caetano, Carlos; Granja, Diana; Pinto, Ricardo; Mendes, Bruno; Sousa, Mónica

    2017-05-12

    Contemporary elite soccer features increased physical demands during match-play, as well as a larger number of matches per season. Now more than ever, aspects related to performance optimization are highly regarded by both players and soccer coaches. Here, nutrition takes a special role as most elite teams try to provide an adequate diet to guarantee maximum performance while ensuring a faster recovery from matches and training exertions. It is currently known that manipulation and periodization of macronutrients, as well as sound hydration practices, have the potential to interfere with training adaptation and recovery. A careful monitoring of micronutrient status is also relevant to prevent undue fatigue and immune impairment secondary to a deficiency status. Furthermore, the sensible use of evidence-based dietary supplements may also play a role in soccer performance optimization. In this sense, several nutritional recommendations have been issued. This detailed and comprehensive review addresses the most relevant and up-to-date nutritional recommendations for elite soccer players, covering from macro and micronutrients to hydration and selected supplements in different contexts (daily requirements, pre, peri and post training/match and competition).

  3. Structuring supplemental materials in support of reproducibility.

    Science.gov (United States)

    Greenbaum, Dov; Rozowsky, Joel; Stodden, Victoria; Gerstein, Mark

    2017-04-05

    Supplements are increasingly important to the scientific record, particularly in genomics. However, they are often underutilized. Optimally, supplements should make results findable, accessible, interoperable, and reusable (i.e., "FAIR"). Moreover, properly off-loading to them the data and detail in a paper could make the main text more readable. We propose a hierarchical organization for supplements, with some parts paralleling and "shadowing" the main text and other elements branching off from it, and we suggest a specific formatting to make this structure explicit. Furthermore, sections of the supplement could be presented in multiple scientific "dialects", including machine-readable and lay-friendly formats.

  4. Atmospheric deposition as an important nitrogen load to a typical agro-ecosystem in the Huang-Huai-Hai Plain. 2. Seasonal and inter-annual variations and their implications (2008-2012)

    Science.gov (United States)

    Huang, Ping; Zhang, Jiabao; Ma, Donghao; Wen, Zhaofei; Wu, Shengjun; Garland, Gina; Pereira, Engil Isadora Pujol; Zhu, Anning; Xin, Xiuli; Zhang, Congzhi

    2016-03-01

    Atmospheric nitrogen (N) deposition, an important N source to agro-ecosystems, has increased intensively in China during recent decades. However, knowledge on temporal variations of total N deposition and their influencing factors is limited due to lack of systematic monitoring data. In this study, total N deposition, including dry and wet components, was monitored using the water surrogate surface method for a typical agro-ecosystem with a winter wheat (Triticum aestivum L.) and summer maize (Zea mays L.) rotation system in the Huang-Huai-Hai Plain from May 2008 to April 2012. The results indicated that annual total N deposition ranged from 23.8 kg N ha-1 (2009-2010) to 40.3 kg N ha-1 (2008-2009) and averaged 31.8 kg N ha-1. Great inter-annual variations were observed during the sampling period, due to differences in annual rainfall and gaseous N losses from farmlands. Monthly total N deposition varied greatly, from less than 0.6 kg N ha-1 (January, 2010) to over 8.0 kg N ha-1 (August, 2008), with a mean value of 2.6 kg N ha-1. In contrast to wet deposition, dry portions generally contributed more to the total, except in the precipitation-intensive months, accounting for 65% in average. NH4+ -N was the dominant species in N deposition and its contribution to total deposition varied from 6% (December, 2009) to 79% (July, 2008), averaging 53%. The role of organic N (O-N) in both dry and wet deposition was equal to or even greater than that of NO3- -N. Influencing factors such as precipitation and its seasonal distribution, reactive N sources, vegetation status, field management practices, and weather conditions were responsible for the temporal variations of atmospheric N deposition and its components. These results are helpful for reducing the knowledge gaps in the temporal variations of atmospheric N deposition and their influencing factors in different ecosystems, to improve the understandings on N budget in the typical agro-ecosystem, and to provide references

  5. « ImpersoNations » : cinéma national, imaginaires historiques et nouveau cinéma européen

    OpenAIRE

    Elsaesser, Thomas

    2014-01-01

    La question du capital culturel propre à la diversité linguistique de l’Europe reste entière. Quels sont les avantages et les inconvénients de cet éventail de langues dans le cinéma ? Les films, quand ils franchissent les frontières, sont souvent doublés. Or, comme un bon jeu d’acteur représente une symbiose très particulière entre le corps, la gestuelle, la voix et l’intonation, les amateurs de cinéma ne peuvent se passer des films tournés dans leur propre langue. A l’instar du son, qui revê...

  6. Study of MA Effect on Yield Strength and Ductility of X80 Linepipe Steels Weld

    Science.gov (United States)

    Huda, Nazmul; Lazor, Robert; Gerlich, Adrian P.

    2017-09-01

    Multipass GMAW (Gas Metal Arc Welding) welding was used to join X80 linepipe materials using two weld metals of slightly different compositions. Welding wires with diameters of 0.984 and 0.909 mm were used while applying the same heat input in each pass. The slight difference in the wire diameters resulted in different HAZ microstructures. The microstructures in the doubly reheated HAZ of both welds were found to contain bainite-ferrite. However, etching also revealed a difference in martensite-austenite (MA) fraction in these reheated zones. The MA exhibited twice the hardness of ferrite when measured by nanoindentation. Tensile testing from the reheated zone of both welds revealed a difference in yield strength, tensile strength and elongation of the transverse weld specimens. In the reheated zone of weld A, (produced with a 0.984 mm wire) a higher fraction of MA was observed, which resulted in higher strength but lower elongation compared to weld B. The ductility of weld A was found severely impaired (to nearly half of weld B) due to formation of closely spaced voids around the MA, along with debonding of MA from the matrix, which occurs just above the yield stress.

  7. y comercialización de maíz de Sinaloa

    Directory of Open Access Journals (Sweden)

    José Alberto García Salazar

    2006-01-01

    Full Text Available La política comercial instrumentada por el Gobierno de México dirigida al mercado de maíz se ha caracterizado por la autorización de importaciones libres de arancel superiores a la cuota establecida en el Tratado de Libre Comercio de América del Norte. Con el objetivo de analizar cómo esta política podría afectar la comercialización de la producción de maíz de Sinaloa, se usó un modelo de distribución de la producción del grano que incorpora características espaciales e intertemporales. Los resultados indican que si el consumo nacional real de maíz fuera menor en 10%, respecto al consumo nacional aparente, las mayores importaciones determinarían que 954 mil toneladas de la producción de la entidad no pudrían comercializarse. Debido a que esta situación resta competitividad al productor de maíz, puesto que la producción no comercializada tiene que almacenarse, los productores sinaloenses deberán estar pendientes y vigilar las decisiones del Gobierno en materia de cupos de importación de maíz.

  8. FİLMLERLE İLETİŞİM VE YABANCILAŞMA

    OpenAIRE

    ÖZTÜRK, Serdar

    2018-01-01

    Yabancılaşma konusu genellikle iktisadi, sosyolojik ve psikoloji boyutlarıyla tartışılmıştır. Oysa bir anlam paylaşımı olarak iletişim, yabancılaşmayla doğrudan ilişkilidir. Buna karşın iletişim ile yabancılaşma ilişkisini, analize filmleri de katarak inceleyen çok az çalışma bulunmaktadır. Bu çalışma, yabancılaşma kavramını tartışarak, yabancılaşmanın iletişim ile ilişkisini incelemektedir. Buna göre insanın kendi ürettiği sembollerine, medyanın üretim bölgesinde üretilen sembollere yabancıl...

  9. M&A Performance and Economic Impact: Integration and Critical Assessment of Methodological Approach

    Directory of Open Access Journals (Sweden)

    Karolis Andriuskevicius

    2017-11-01

    Full Text Available Purpose of the article: Existing methodologies employed within the M&A performance framework are investigated and critically discuss. Methodology/methods: The research has been carried out as a structured assessment of past literature. The findings from scientific articles and studies by various scholars have been categorized, grouped and summarized to discern a meta-analytic view of the work carried out to date. Scientific aim: The conducted research seeks to ascertain and evaluate theoretically existing methodologies used in empirical studies that would allow proper and critical understanding of the results of various findings in the holistic and global M&As area. Findings: The research elaborates on several key developments in M&A methodology and performance studies carried out in empirical works during the last two decades. The findings help to independently and objectively assess performance of M&A from a holistic perspective. Conclusions: Each methodology measuring either M&A performance on a corporate level or effects of M&A on the economy level shall be interpreted and relied on with caution as each of them dispose their limitations whereas application of these methodologies is subject to data availability and case specific.

  10. Separation of minor actinides from a genuine MA/LN fraction

    International Nuclear Information System (INIS)

    Satmark, B.; Courson, O.; Malmbeck, R.; Pagliosa, G.; Romer, K.; Glatz, J.P.

    2001-01-01

    Separation of the trivalent Minor Actinides (MA), Am and Cm, has been performed from a genuine MA(III) + Ln(III) solution using Bis-Triazine-Pyridine (BTP) as organic extractant. The representative MA/Ln fraction was obtained from a dissolved commercial LWR fuel (45.2 GWd/tM) submitted subsequently too a PUREX process followed by a DIAMEX process. A centrifugal extractor set-up (16-stages), working in a continuous counter-current mode, was used for the liquid-liquid separation. In the nPr-BTP process, feed decontamination factors for Am and Cm above 96 and 65, respectively were achieved. The back-extraction was more efficient for Am (99.1% recovery) than for Cm (97.5%). This experiment, using the Bis-Triazine-Pyridine molecule is the first successful demonstration of the separation of MA from lanthanides in a genuine MA/Ln fraction with a nitric acid concentration of ca. 1 M. It represents an important break through in the difficult field of minor actinide partitioning of high level liquid waste. (author)

  11. DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo.

    Science.gov (United States)

    Zubradt, Meghan; Gupta, Paromita; Persad, Sitara; Lambowitz, Alan M; Weissman, Jonathan S; Rouskin, Silvi

    2017-01-01

    Coupling of structure-specific in vivo chemical modification to next-generation sequencing is transforming RNA secondary structure studies in living cells. The dominant strategy for detecting in vivo chemical modifications uses reverse transcriptase truncation products, which introduce biases and necessitate population-average assessments of RNA structure. Here we present dimethyl sulfate (DMS) mutational profiling with sequencing (DMS-MaPseq), which encodes DMS modifications as mismatches using a thermostable group II intron reverse transcriptase. DMS-MaPseq yields a high signal-to-noise ratio, can report multiple structural features per molecule, and allows both genome-wide studies and focused in vivo investigations of even low-abundance RNAs. We apply DMS-MaPseq for the first analysis of RNA structure within an animal tissue and to identify a functional structure involved in noncanonical translation initiation. Additionally, we use DMS-MaPseq to compare the in vivo structure of pre-mRNAs with their mature isoforms. These applications illustrate DMS-MaPseq's capacity to dramatically expand in vivo analysis of RNA structure.

  12. Paraneoplastic brain stem encephalitis in a woman with anti-Ma2 antibody.

    Science.gov (United States)

    Barnett, M; Prosser, J; Sutton, I; Halmagyi, G M; Davies, L; Harper, C; Dalmau, J

    2001-02-01

    A woman developed brain stem encephalopathy in association with serum anti-Ma2 antibodies and left upper lobe lung mass. T2 weighted MRI of the brain showed abnormalities involving the pons, left middle and superior cerebellar peduncles, and bilateral basal ganglia. Immunohistochemical analysis for serum antineuronal antibodies was confounded by the presence of a non-neuronal specific antinuclear antibody. Immunoblot studies showed the presence of anti-Ma2 antibodies. A premortem tissue diagnosis of the lung mass could not be established despite two CT guided needle biopsies, and the patient died as a result of rapid neurological deterioration. The necropsy showed that the lung lesion was an adenocarcinoma which expressed Ma2 immunoreactive protein. Neuropathological findings included prominent perivascular inflammatory infiltrates, glial nodules, and neuronophagia involving the brain stem, basal ganglia, hippocampus and the dentate nucleus of the cerebellum. Ma2 is an autoantigen previously identified in patients with germ cell tumours of the testis and paraneoplastic brain stem and limbic encephalitis. Our patient's clinical and immunopathological findings indicate that this disorder can affect women with lung adenocarcinoma, and that the encephalitic changes predominate in those regions of the brain known to express high concentrations of Ma proteins.

  13. Spontaneous atopic dermatitis-like symptoms in a/a ma ft/ma ft/J flaky tail mice appear early after birth.

    Directory of Open Access Journals (Sweden)

    Magdalini Kypriotou

    Full Text Available Loss-of-function mutations in human profilaggrin gene have been identified as the cause of ichthyosis vulgaris (IV, and as a major predisposition factor for atopic dermatitis (AD. Similarly, flaky tail (a/a ma ft/ma ft/J mice were described as a model for IV, and shown to be predisposed to eczema. The aim of this study was to correlate the flaky tail mouse phenotype with human IV and AD, in order to dissect early molecular events leading to atopic dermatitis in mice and men, suffering from filaggrin deficiency. Thus, 5-days old flaky tail pups were analyzed histologically, expression of cytokines was measured in skin and signaling pathways were investigated by protein analysis. Human biopsies of IV and AD patients were analyzed histologically and by real time PCR assays. Our data show acanthosis and hyperproliferation in flaky tail epidermis, associated with increased IL1β and thymic stromal lymphopoietin (TSLP expression, and Th2-polarization. Consequently, NFκB and Stat pathways were activated, and IL6 mRNA levels were increased. Further, quantitative analysis of late epidermal differentiation markers revealed increased Small proline-rich protein 2A (Sprr2a synthesis. Th2-polarization and Sprr2a increase may result from high TSLP expression, as shown after analysis of 5-days old K14-TSLP tg mouse skin biopsies. Our findings in the flaky tail mouse correlate with data obtained from patient biopsies of AD, but not IV. We propose that proinflammatory cytokines are responsible for acanthosis in flaky tail epidermis, and together with the Th2-derived cytokines lead to morphological changes. Accordingly, the a/a ma ft/ma ft/J mouse model can be used as an appropriate model to study early AD onset associated with profilaggrin deficiency.

  14. Evaluation of biodegradation of bionanocomposites of PHB/PP-g-MA/vermiculite; Avaliacao da biodegradacao de bionanocompositos de PHB/PP-g-MA/vermiculita

    Energy Technology Data Exchange (ETDEWEB)

    Mesquita, P.J.P. de; Alves, T.S.; Barbosa, R., E-mail: tsaeng3@yahoo.com.br [Universidade Federal do Piaui (UFPI), Teresina, PI (Brazil). Programa de Pos-Graduacao em Ciencia dos Materiais; Andrade, D. de L.A.C.S. [Universidade Federal de Campina Grande (UFCG), PB (Brazil). Programa de Pos- Graduacao em Ciencia e Engenharia de Materiais

    2014-07-01

    In this work, we evaluated the process of biodegradation of PHB bionanocomposites/PP-g-MA/clay. Films were prepared with compositions of 5% PP-g-MA and 3% clay (BIO5); and 2.5% PP-g-MA and 3% clay (BIO2.5). The biodegradation test was conducted according to ASTM G 160-03 for a period of 86 days. The evaluation of biodegradation was performed by optical microscopy (MO), loss of mass, FTIR and XRD. The bionanocomposites presented change of coloration and appearance of fissures. As for loss in mass in the system presented loss of BIO2,5 22.5% and 25.9% BIO5, for 86 days of simulated soil exposure. We also observed by FTIR sharp reduction in intensity of the band corresponding to the C = O groups, indicating that the microbial attack promoted cleavage of the ester group links. By XRD, reduction in the intensity of the peaks and enlargements of the same with increasing exposure time, proving the biodegradation behavior of bionanocomposites. (author)

  15. Factors associated with dietary supplement use by people who exercise at gyms

    Directory of Open Access Journals (Sweden)

    Francisca Mirian Moura Lacerda

    2015-01-01

    Full Text Available OBJECTIVE To assess the factors associated with the use of dietary supplements by people who exercise at gyms.METHODS A cross-sectional study with a sample defined by convenience, considering the number of gyms registered in the Conselho Regional de Educação Física (Regional Council of Physical Education of Sao Luis, MA, Northeastern Brazil, from July 2011 to July 2012. The final sample comprised 723 individuals who exercise at gyms. The dependent variable was supplement use, and the explanatory variables were length of time and motivation of the physical exercises, duration, goal and self-perception of training, weekly frequency of gym attendance, sex, age, educational attainment, self-perception of body weight, smoking and self-perception of diet. The association between variables was analysed by hierarchical Poisson regression based on a theoretical model.RESULTS Supplement use was reported by 64.7% of the participants. Most of the sample was male (52.6%. The most frequent age group was 20 to 39 years (74.4%. Most participants (46.1% had been exercising for over a year. The following variables were associated with supplement use: self-perceiving body weight as below ideal (p < 0.001, smoking (p < 0.001, exercising for 7 to 12 months (p = 0.028 or more than one year (p < 0.001, spending more than two hours at the gym (p = 0.051, and perceiving training as moderate (p = 0.024 or intense (p = 0.001.CONCLUSIONS The use of supplements lacks proper professional guidance, being motivated by individuals unsatisfied with their low body weight and who perceive their workout as intense, which raises the need for monitoring this population.

  16. 20 CFR 227.2 - Initial supplemental annuity rate.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Initial supplemental annuity rate. 227.2... COMPUTING SUPPLEMENTAL ANNUITIES § 227.2 Initial supplemental annuity rate. The supplemental annuity rate... supplemental annuity rate is $43 for an employee with 30 or more years of service. ...

  17. Microprobe monazite constraints for and early (ca. 790 Ma) Braziliano orogeny: The Embu Terrane, southeastern Brazil

    International Nuclear Information System (INIS)

    Vlach, Silvio R.F

    2001-01-01

    The evolution of the Mantiqueira Orogenetic System, Southeastern Brazil, comprises discrete episodes of tectonic collage and docking of remnants of Rodinia break-up in the borders of the Sao Francisco Craton. This system is related to the closure of the Adamastor ocean and assemblage of the western Gondwana super-continent during Neoproterozoic times (ca. 610-530 Ma, Brito Neves et al., 1999; Campos Neto, 2000). This report presents monazite microprobe dating results for metassediments from the Embu Complex, an important lithological unit from the Ribeira Belt, currently included in the Juiz de Fora terrane, a unit added to the Sao Francisco Craton at ca. 600-580 Ma. (Campos Neto, 2000). The age results unravel a main metamorphic episode and related orogeny at ca. 790 Ma and bring new insights concerning the agglutination of Gondwana in this region during the Neoproterozoic (au)

  18. Precio del maíz en México y ley del precio único

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Martínez Damián

    2017-01-01

    Full Text Available El abasto de maíz debe cubrirse con importaciones de Estados Unidos de América ( ee. uu. . Si dicho intercambio es de libre comercio, entonces debe observarse la ley del precio único ( lpu . Bajo un modelo vectorial de corrección de error, se examina la lpu para el precio de maíz en México y ee. uu . Los resultados si bien rechazan estadísticamente la lpu , el vector cointegrante estimado es de signo y magnitud acorde con la lpu , dicho vector implica la existencia de una combinación lineal estacionaria que provee evidencia de integración de mercados. Secundariamente se encuentra que el precio de maíz en México es causado, en el sentido de Granger, por el precio en ee. uu. y que dicho precio no es exógeno al vector examinado.

  19. CULTURAL DUE DILIGENCE IN M&A. IMPORTANCE OF SOFT RISKS FACTORS

    Directory of Open Access Journals (Sweden)

    Iulian Walter

    2017-07-01

    Full Text Available During the last decades, the corporate world has witnessed a significant rise in the number of cross border mergers and acquisitions (M&As. In cross border M&As, not only different corporate cultures collide, but also different professional and national cultures. The purpose of Cultural Due Diligence (CDD is to get a coherent image of the intercultural challenges of the M&A in order to be aware of the intercultural risks and opportunities. This article aims to reveal the perception of managers involved in the pre-M&A stage on the soft risks factors that need to be investigated during CDD. This study proposes an appraisal of the most important intercultural issues that need to be considered in M&A. Our contribution to the intercultural aspects of M&A literature consists in improving the current understanding of Cultural Due Diligence content.

  20. Earth's youngest exposed granite and its tectonic implications: the 10-0.8 Ma Kurobegawa Granite.

    Science.gov (United States)

    Ito, Hisatoshi; Yamada, Ryuji; Tamura, Akihiro; Arai, Shoji; Horie, Kenji; Hokada, Tomokazu

    2013-01-01

    Although the quest for Earth's oldest rock is of great importance, identifying the youngest exposed pluton on Earth is also of interest. A pluton is a body of intrusive igneous rock that crystallized from slowly cooling magma at depths of several kilometers beneath the surface of the Earth. Therefore, the youngest exposed pluton represents the most recent tectonic uplift and highest exhumation. The youngest exposed pluton reported to date is the Takidani Granodiorite (~ 1.4 Ma) in the Hida Mountain Range of central Japan. Using LA-ICP-MS and SHRIMP U-Pb zircon dating methods, this study demonstrates that the Kurobegawa Granite, also situated in the Hida Mountain Range, is as young as ~ 0.8 Ma. In addition, data indicate multiple intrusion episodes in this pluton since 10 Ma with a ~ 2-million-year period of quiescence; hence, a future intrusion event is likely within 1 million years.

  1. La evolución del mejoramiento del maíz

    OpenAIRE

    Arriaga, Héctor O.

    1987-01-01

    La producción e importancia primordial del maíz como grano forrajero, hacen que se sindique al maíz como el cereal más representativo de los países desarrollados. Por su producción mundial, ocupa el 2° lugar, después del trigo, con 481 millones de toneladas, de las que el 64 % corresponde a los países desarrollados. Estos son, a su vez, los principales exportadores y consumidores por ser también los más importantes importadores, con un 71 % de las 68 millones de toneladas de maíz que se...

  2. MA-core loaded untuned RF compression cavity for HIRFL-CSR

    International Nuclear Information System (INIS)

    Mei Lirong; Xu Zhe; Yuan Youjin; Jin Peng; Bian Zhibin; Zhao Hongwei; Xia Jiawen

    2012-01-01

    To meet the requirements of high energy density physics and plasma physics research at HIRFL-CSR the goal of achieving a higher accelerating gap voltage was proposed. Therefore, a magnetic alloy (MA)-core loaded radio frequency (RF) cavity that can provide a higher accelerating gap voltage compared to standard ferrite loaded cavities has been studied at IMP. In order to select the proper magnetic alloy material to load the RF compression cavity, measurements of four different kinds of sample MA-cores have been carried out. By testing the small cores, the core composition was selected to obtain the desired performance. According to the theoretical calculation and simulation, which show reasonable consistency for the MA-core loaded cavity, the desired performance can be achieved. Finally about 1000 kW power will be needed to meet the requirements of 50 kV accelerating gap voltage by calculation.

  3. CULTURAL DUE DILIGENCE IN M&A. IMPORTANCE OF SOFT RISKS FACTORS

    Directory of Open Access Journals (Sweden)

    Iulian Warter

    2017-06-01

    Full Text Available During the last decades, the corporate world has witnessed a significant rise in the number of cross border mergers and acquisitions (M&As. In cross border M&As, not only different corporate cultures collide, but also different professional and national cultures. The purpose of Cultural Due Diligence (CDD is to get a coherent image of the intercultural challenges of the M&A in order to be aware of the intercultural risks and opportunities. This article aims to reveal the perception of managers involved in the pre-M&A stage on the soft risks factors that need to be investigated during CDD. This study proposes an appraisal of the most important intercultural issues that need to be considered in M&A. Our contribution to the intercultural aspects of M&A literature consists in improving the current understanding of Cultural Due Diligence content.

  4. Development and tests of fast 1-MA linear transformer driver stages

    Directory of Open Access Journals (Sweden)

    A. A. Kim

    2009-05-01

    Full Text Available In this article we present the design and test results of the most powerful, fast linear transformer driver (LTD stage developed to date. This 1-MA LTD stage consists of 40 parallel RLC (resistor R, inductor L, and capacitor C circuits called “bricks” that are triggered simultaneously; it is able to deliver ∼1  MA current pulse with a rise time of ∼100  ns into the ∼0.1-Ohm matched load. The electrical behavior of the stage can be predicted by using a simple RLC circuit, thus simplifying the designing of various LTD-based accelerators. Five 1-MA LTD stages assembled in series into a module have been successfully tested with both resistive and vacuum electron-beam diode loads.

  5. Kuznetsov-Ma waves train generation in a left-handed material

    Science.gov (United States)

    Atangana, Jacques; Giscard Onana Essama, Bedel; Biya-Motto, Frederick; Mokhtari, Bouchra; Cherkaoui Eddeqaqi, Noureddine; Crépin Kofane, Timoléon

    2015-03-01

    We analyze the behavior of an electromagnetic wave which propagates in a left-handed material. Second-order dispersion and cubic-quintic nonlinearities are considered. This behavior of an electromagnetic wave is modeled by a nonlinear Schrödinger equation which is solved by collective coordinates theory in order to characterize the light pulse intensity profile. More so, a specific frequency range has been outlined where electromagnetic wave behavior will be investigated. The perfect combination of second-order dispersion and cubic nonlinearity leads to a robust soliton. When the quintic nonlinearity comes into play, it provokes strong and long internal perturbations which lead to Benjamin-Feir instability. This phenomenon, also called modulational instability, induces appearance of a Kuznetsov-Ma waves train. We numerically verify the validity of Kuznetsov-Ma theory by presenting physical conditions which lead to Kuznetsov-Ma waves train generation. Thereafter, some properties of such waves train are also verified.

  6. DaMaSCUS-CRUST: Dark Matter Simulation Code for Underground Scatterings - Crust Edition

    Science.gov (United States)

    Emken, Timon; Kouvaris, Chris

    2018-03-01

    DaMaSCUS-CRUST determines the critical cross-section for strongly interacting DM for various direct detection experiments systematically and precisely using Monte Carlo simulations of DM trajectories inside the Earth's crust, atmosphere, or any kind of shielding. Above a critical dark matter-nucleus scattering cross section, any terrestrial direct detection experiment loses sensitivity to dark matter, since the Earth crust, atmosphere, and potential shielding layers start to block off the dark matter particles. This critical cross section is commonly determined by describing the average energy loss of the dark matter particles analytically. However, this treatment overestimates the stopping power of the Earth crust; therefore, the obtained bounds should be considered as conservative. DaMaSCUS-CRUST is a modified version of DaMaSCUS (ascl:1706.003) that accounts for shielding effects and returns a precise exclusion band.

  7. Molecular mechanisms and in vitro antioxidant effects of Lactobacillus plantarum MA2.

    Science.gov (United States)

    Tang, Wei; Xing, Zhuqing; Li, Chao; Wang, Jinju; Wang, Yanping

    2017-04-15

    Lactobacillus plantarum MA2 was isolated from Chinese traditional Tibetan kefir grains. The antioxidant activities in vitro of this strain were evaluated extensively. The results showed that L. plantarum MA2 can tolerate hydrogen peroxide up to 2.0mM, and its fermentate (fermented supernatant, intact cell and cell-free extract) had strong reducing capacities, lipid peroxidation inhibition capacities, Fe 2+ -chelating abilities, as well as various free radical scavenging capacities. Additionally, both the fermented supernatant and cell homogenate exhibited glutathione peroxidase activity and superoxide dismutase activity. In order to investigate the antioxidant mechanism of L. plantarum MA2 at the molecular level, eight antioxidant-related genes were identified, and further analyzed. Three groups of genes cat, gshR and npx, were found up-regulated under H 2 O 2 challenge. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Flux consumption optimization and the achievement of 1 MA discharges on NSTX

    International Nuclear Information System (INIS)

    Menard, J.; LeBlanc, B.; Sabbagh, S.A.

    2001-01-01

    The spherical tokamak (ST), because of its slender central column, has very limited volt-second capability relative to a standard aspect ratio tokamak of similar plasma cross-section. Recent experiments on the National Spherical Torus Experiment (NSTX) have begun to quantify and optimize the ohmic current drive efficiency in a MA-class ST device. Sustainable ramp-rates in excess of 5MA/sec during the current rise phase have been achieved on NSTX, while faster ramps generate significant MHD activity. Discharges with I P exceeding 1MA have been achieved in NSTX with nominal parameters: aspect ratio A=1.3-1.4, elongation κ=2-2.2, triangularity δ=0.4, internal inductance l i =0.6, and Ejima coefficient C E =0.35. Flux consumption efficiency results, performance improvements associated with first boronization, and comparisons to neoclassical resistivity are described. (author)

  9. Supplemental report on cost estimates'

    International Nuclear Information System (INIS)

    1992-01-01

    The Office of Management and Budget (OMB) and the U.S. Army Corps of Engineers have completed an analysis of the Department of Energy's (DOE) Fiscal Year (FY) 1993 budget request for its Environmental Restoration and Waste Management (ERWM) program. The results were presented to an interagency review group (IAG) of senior-Administration officials for their consideration in the budget process. This analysis included evaluations of the underlying legal requirements and cost estimates on which the ERWM budget request was based. The major conclusions are contained in a separate report entitled, ''Interagency Review of the Department of Energy Environmental Restoration and Waste Management Program.'' This Corps supplemental report provides greater detail on the cost analysis

  10. Dietary Supplements: What You Need to Know

    Science.gov (United States)

    ... product. How can I be a smart supplement shopper? Be a savvy supplement user. Here’s how: • When ... gov/Safety/ReportaProblem/ConsumerComplaintCoordinators • File a safety report online through the Safety Reporting Portal at: http://www. ...

  11. Supplement use and mortality: the SENECA study

    NARCIS (Netherlands)

    Brzozowska, A.; Kaluza, J.; Knoops, K.T.B.; Groot, de C.P.G.M.

    2008-01-01

    Background It is hypothesis that in relatively healthy older people supplement usage can be consider as healthy life style habit and as such can positively influence longevity. Aim of the study To determine whether supplement use was associated with all-cause mortality in the participants of the

  12. Use of dietary supplements among Brazilian athletes

    Directory of Open Access Journals (Sweden)

    Hellen Clair Garcez NABUCO

    Full Text Available ABSTRACT Objective: To investigate the prevalence and establish the profile of the consumption of dietary supplements among Brazilian athletes. Methods: A total of 182 athletes of both genders from 20 different sports participated in this study. The athletes answered a questionnaire containing sociodemographic and sports-related questions and were interviewed about the consumption of dietary supplements. Results: Forty seven percent of athletes reported having consumed at least one type of dietary supplement and 38% said they use more than three different types of supplements concurrently. Whey protein was the most commonly consumed supplement, and the most frequently mentioned reason for its consumption was performance improvement. The main source of information was coaches, and individual sport athletes were the greatest consumers and the most likely to seek dietary supplement. Conclusion: Approximately half of the participants used dietary supplements, which on most occasions were recommended by coaches. The consumption profile also revealed multiple supplementation practice and showed that nutrition education is essential for this specific population.

  13. Methionine supplementation in the productive efficiency, carcass ...

    African Journals Online (AJOL)

    The effect of dietary methionine supplementation at varying levels on the productive efficiency, carcass characteristics and economics of growing indigenous turkey was investigated. Four Isocaloric and Isonitrogenous diets were formulated. The diets were supplemented with 0.00%, 0.05%, 0.10%, and 0.15% respectively.

  14. 30 CFR 75.361 - Supplemental examination.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Supplemental examination. 75.361 Section 75.361... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Ventilation § 75.361 Supplemental examination. (a) Except for certified persons conducting examinations required by this subpart, within 3 hours before anyone...

  15. Enhanced Nutrition Education Instead of Consuming Supplements

    Science.gov (United States)

    Crowder, Todd; Kidd, Kellie; Jensen, Nancy; Jensen, Laura

    2008-01-01

    Fueled by the internet, instantaneous videos, and the emphasis to look "right" or always win athletic competitions, many students are seeking information on nutrition and dietary supplements. Classroom observations reveal student interest and discussions are among the highest when the topic is dietary supplements. Teachers and coaches provide an…

  16. Should infant girls receive micronutrient supplements?

    DEFF Research Database (Denmark)

    Benn, Christine Stabell; Lund, Sofia; Fisker, Ane

    2009-01-01

    BACKGROUND: We have proposed the hypothesis that the combination of vitamin A supplementation and diphtheria-tetanus-pertussis (DTP) vaccination may be associated with increased mortality in girls. Recent zinc/folic acid (FA) and iron supplementation trials did not find any beneficial effects...

  17. Nutritional supplement intake knowledge among university active ...

    African Journals Online (AJOL)

    The purpose of this study is to examine the nutritional supplement intake knowledge among university athletes. Fifty-one university athletes volunteered to participate in this survey study. Results showed the nutritional supplement intake was significantly higher compared to the knowledge that they have about the ...

  18. Attitudes towards nutritional supplement use amongst adult ...

    African Journals Online (AJOL)

    Background: Nutritional supplements refer to a product ingested to increase the nutritional content of a normal diet, to fill a dietary need and/or presumed deficiency. The usage and popularity of nutritional supplements, however, raises concerns from a health benefit and risk perspective. In South Africa, there is currently no ...

  19. Antioxidant supplements for preventing gastrointestinal cancers

    DEFF Research Database (Denmark)

    Bjelakovic, G; Nikolova, D; Simonetti, R G

    2004-01-01

    Oxidative stress may cause gastrointestinal cancers. The evidence on whether antioxidant supplements are effective in preventing gastrointestinal cancers is contradictory.......Oxidative stress may cause gastrointestinal cancers. The evidence on whether antioxidant supplements are effective in preventing gastrointestinal cancers is contradictory....

  20. Supplement consumption in body builder athletes

    Science.gov (United States)

    Karimian, Jahangir; Esfahani, Parivash Shekarchizadeh

    2011-01-01

    BACKGROUND: Widespread use of supplements is observed among world athletes in different fields. The aim of this study was to estimate the prevalence and determinants of using supplements among body builder athletes. METHODS: This cross-sectional study was conducted on 250 men and 250 women from 30 different bodybuilding clubs. Participants were asked to complete a self-administered standardized anonymous check-list. RESULTS: Forty nine percent of the respondents declared supplement use. Men were more likely to take supplements than women (86.8% vs. 11.2%, p = 0.001). Reasons for using supplements were reported to be for health (45%), enhancing the immune system (40%) and improving athletic performance (25%). Most athletes (72%) had access to a nutritionist but underused this resource. Coaches (65%) had the greatest influence on supplementation practices followed by nutritionists (30%) and doctors (25%) after them. CONCLUSIONS: The prevalence of supplement use among bodybuilders was high. Sex, health-related issues and sport experts were determinant factors of supplement use. PMID:22973330

  1. THE DATA REDUCTION PIPELINE FOR THE SDSS-IV MaNGA IFU GALAXY SURVEY

    Energy Technology Data Exchange (ETDEWEB)

    Law, David R. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Cherinka, Brian [Center for Astrophysical Sciences, Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD 21218 (United States); Yan, Renbin [Department of Physics and Astronomy, University of Kentucky, 505 Rose Street, Lexington, KY 40506-0055 (United States); Andrews, Brett H. [Department of Physics and Astronomy and PITT PACC, University of Pittsburgh, 3941 O’Hara Street, Pittsburgh, PA 15260 (United States); Bershady, Matthew A. [Department of Astronomy, University of Wisconsin-Madison, 475 N. Charter Street, Madison, WI 53706 (United States); Bizyaev, Dmitry [Apache Point Observatory, P.O. Box 59, Sunspot, NM 88349 (United States); Blanc, Guillermo A. [Departamento de Astronomía, Universidad de Chile, Camino del Observatorio 1515, Las Condes, Santiago (Chile); Blanton, Michael R. [Center for Cosmology and Particle Physics, Department of Physics, New York University, 4 Washington Place, New York, NY 10003 (United States); Bolton, Adam S.; Brownstein, Joel R. [Department of Physics and Astronomy, University of Utah, 115 S 1400 E, Salt Lake City, UT 84112 (United States); Bundy, Kevin [Kavli Institute for the Physics and Mathematics of the universe, Todai Institutes for Advanced Study, the University of Tokyo, Kashiwa, 277-8583 (Kavli IPMU, WPI) (Japan); Chen, Yanmei [School of Astronomy and Space Science, Nanjing University, Nanjing 210093 (China); Drory, Niv [McDonald Observatory, Department of Astronomy, University of Texas at Austin, 1 University Station, Austin, TX 78712-0259 (United States); D’Souza, Richard; Jones, Amy; Kauffmann, Guinevere [Max Planck Institute for Astrophysics, Karl-Schwarzschild-Str. 1, D-85748 Garching (Germany); Fu, Hai, E-mail: dlaw@stsci.edu [Department of Physics and Astronomy, University of Iowa, Iowa City, IA 52242 (United States); and others

    2016-10-01

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) is an optical fiber-bundle integral-field unit (IFU) spectroscopic survey that is one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV). With a spectral coverage of 3622–10354 Å and an average footprint of ∼500 arcsec{sup 2} per IFU the scientific data products derived from MaNGA will permit exploration of the internal structure of a statistically large sample of 10,000 low-redshift galaxies in unprecedented detail. Comprising 174 individually pluggable science and calibration IFUs with a near-constant data stream, MaNGA is expected to obtain ∼100 million raw-frame spectra and ∼10 million reduced galaxy spectra over the six-year lifetime of the survey. In this contribution, we describe the MaNGA Data Reduction Pipeline algorithms and centralized metadata framework that produce sky-subtracted spectrophotometrically calibrated spectra and rectified three-dimensional data cubes that combine individual dithered observations. For the 1390 galaxy data cubes released in Summer 2016 as part of SDSS-IV Data Release 13, we demonstrate that the MaNGA data have nearly Poisson-limited sky subtraction shortward of ∼8500 Å and reach a typical 10 σ limiting continuum surface brightness μ  = 23.5 AB arcsec{sup −2} in a five-arcsecond-diameter aperture in the g -band. The wavelength calibration of the MaNGA data is accurate to 5 km s{sup −1} rms, with a median spatial resolution of 2.54 arcsec FWHM (1.8 kpc at the median redshift of 0.037) and a median spectral resolution of σ  = 72 km s{sup −1}.

  2. The Data Reduction Pipeline for the SDSS-IV MaNGA IFU Galaxy Survey

    Science.gov (United States)

    Law, David R.; Cherinka, Brian; Yan, Renbin; Andrews, Brett H.; Bershady, Matthew A.; Bizyaev, Dmitry; Blanc, Guillermo A.; Blanton, Michael R.; Bolton, Adam S.; Brownstein, Joel R.; Bundy, Kevin; Chen, Yanmei; Drory, Niv; D'Souza, Richard; Fu, Hai; Jones, Amy; Kauffmann, Guinevere; MacDonald, Nicholas; Masters, Karen L.; Newman, Jeffrey A.; Parejko, John K.; Sánchez-Gallego, José R.; Sánchez, Sebastian F.; Schlegel, David J.; Thomas, Daniel; Wake, David A.; Weijmans, Anne-Marie; Westfall, Kyle B.; Zhang, Kai

    2016-10-01

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) is an optical fiber-bundle integral-field unit (IFU) spectroscopic survey that is one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV). With a spectral coverage of 3622-10354 Å and an average footprint of ˜500 arcsec2 per IFU the scientific data products derived from MaNGA will permit exploration of the internal structure of a statistically large sample of 10,000 low-redshift galaxies in unprecedented detail. Comprising 174 individually pluggable science and calibration IFUs with a near-constant data stream, MaNGA is expected to obtain ˜100 million raw-frame spectra and ˜10 million reduced galaxy spectra over the six-year lifetime of the survey. In this contribution, we describe the MaNGA Data Reduction Pipeline algorithms and centralized metadata framework that produce sky-subtracted spectrophotometrically calibrated spectra and rectified three-dimensional data cubes that combine individual dithered observations. For the 1390 galaxy data cubes released in Summer 2016 as part of SDSS-IV Data Release 13, we demonstrate that the MaNGA data have nearly Poisson-limited sky subtraction shortward of ˜8500 Å and reach a typical 10σ limiting continuum surface brightness μ = 23.5 AB arcsec-2 in a five-arcsecond-diameter aperture in the g-band. The wavelength calibration of the MaNGA data is accurate to 5 km s-1 rms, with a median spatial resolution of 2.54 arcsec FWHM (1.8 kpc at the median redshift of 0.037) and a median spectral resolution of σ = 72 km s-1.

  3. [The medical theory of Lee Je-ma and its character].

    Science.gov (United States)

    Lee, Kyung-Lock

    2005-12-01

    Lee Je-ma 1837-1900) was a prominent scholar as well as an Korean physician. classified every people into four distinctive types: greater yang [tai yang] person, lesser yin [shao yin] person, greater yin [tai yin] person, lesser yin [shao yin] person. This theory would dictate proper treatment for each type in accordance with individual differences of physical and temperament features. Using these four types he created The Medical Science of Four Types. This article is intended to look into the connection between Lee Je-Ma's 'The Medical Science of Four Types' and 'The Modern' with organizing his ideas about the human body and the human being. Through The Modern, the theory of human being underwent a complete change. Human being in The Premodern, which was determined by sex, age and social status has been changed to the individual human being, which is featured by equality. Lee Je-Ma's medical theory of The Medical Science of Four Types would be analyzed as follow. His concept of human body is oriented toward observable objectivity. But on the other hand, it still remains transcendent status of medical science, which is subordinated by philosophy. According to Lee Je-Ma's theory of human being, human is an equal individual in a modern way of thinking, not as a part of hierarchical group. But on the other hand, it still remains incomplete from getting rid of morality aspect that includes virtue and vice in the concept of human body. The common factors in Lee Je-Ma's ideas about the human body and the human being is 'Dualism of mind and body that means all kinds of status and results depends on each individual. As is stated above, Lee Je-Ma's medical theory has many aspects of The Modern and it proves that Korean traditional medicine could be modernized by itself.

  4. Ma_MISS on ExoMars: Mineralogical Characterization of the Martian Subsurface

    Science.gov (United States)

    De Sanctis, Maria Cristina; Altieri, Francesca; Ammannito, Eleonora; Biondi, David; De Angelis, Simone; Meini, Marco; Mondello, Giuseppe; Novi, Samuele; Paolinetti, Riccardo; Soldani, Massimo; Mugnuolo, Raffaele; Pirrotta, Simone; Vago, Jorge L.; Ma_MISS Team

    2017-07-01

    The Ma_MISS (Mars Multispectral Imager for Subsurface Studies) experiment is the visible and near infrared (VNIR) miniaturized spectrometer hosted by the drill system of the ExoMars 2020 rover. Ma_MISS will perform IR spectral reflectance investigations in the 0.4-2.2 μm range to characterize the mineralogy of excavated borehole walls at different depths (between 0 and 2 m). The spectral sampling is about 20 nm, whereas the spatial resolution over the target is 120 μm. Making use of the drill's movement, the instrument slit can scan a ring and build up hyperspectral images of a borehole. The main goal of the Ma_MISS instrument is to study the martian subsurface environment. Access to the martian subsurface is crucial to our ability to constrain the nature, timing, and duration of alteration and sedimentation processes on Mars, as well as habitability conditions. Subsurface deposits likely host and preserve H2O ice and hydrated materials that will contribute to our understanding of the H2O geochemical environment (both in the liquid and in the solid state) at the ExoMars 2020 landing site. The Ma_MISS spectral range and sampling capabilities have been carefully selected to allow the study of minerals and ices in situ before the collection of samples. Ma_MISS will be implemented to accomplish the following scientific objectives: (1) determine the composition of subsurface materials, (2) map the distribution of subsurface H2O and volatiles, (3) characterize important optical and physical properties of materials (e.g., grain size), and (4) produce a stratigraphic column that will inform with regard to subsurface geological processes. The Ma_MISS findings will help to refine essential criteria that will aid in our selection of the most interesting subsurface formations from which to collect samples.

  5. THE DATA REDUCTION PIPELINE FOR THE SDSS-IV MaNGA IFU GALAXY SURVEY

    International Nuclear Information System (INIS)

    Law, David R.; Cherinka, Brian; Yan, Renbin; Andrews, Brett H.; Bershady, Matthew A.; Bizyaev, Dmitry; Blanc, Guillermo A.; Blanton, Michael R.; Bolton, Adam S.; Brownstein, Joel R.; Bundy, Kevin; Chen, Yanmei; Drory, Niv; D’Souza, Richard; Jones, Amy; Kauffmann, Guinevere; Fu, Hai

    2016-01-01

    Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) is an optical fiber-bundle integral-field unit (IFU) spectroscopic survey that is one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV). With a spectral coverage of 3622–10354 Å and an average footprint of ∼500 arcsec 2 per IFU the scientific data products derived from MaNGA will permit exploration of the internal structure of a statistically large sample of 10,000 low-redshift galaxies in unprecedented detail. Comprising 174 individually pluggable science and calibration IFUs with a near-constant data stream, MaNGA is expected to obtain ∼100 million raw-frame spectra and ∼10 million reduced galaxy spectra over the six-year lifetime of the survey. In this contribution, we describe the MaNGA Data Reduction Pipeline algorithms and centralized metadata framework that produce sky-subtracted spectrophotometrically calibrated spectra and rectified three-dimensional data cubes that combine individual dithered observations. For the 1390 galaxy data cubes released in Summer 2016 as part of SDSS-IV Data Release 13, we demonstrate that the MaNGA data have nearly Poisson-limited sky subtraction shortward of ∼8500 Å and reach a typical 10 σ limiting continuum surface brightness μ  = 23.5 AB arcsec −2 in a five-arcsecond-diameter aperture in the g -band. The wavelength calibration of the MaNGA data is accurate to 5 km s −1 rms, with a median spatial resolution of 2.54 arcsec FWHM (1.8 kpc at the median redshift of 0.037) and a median spectral resolution of σ  = 72 km s −1 .

  6. Conceptual Framework: Development of Interactive Reading Malay Language Learning System (I-ReaMaLLS

    Directory of Open Access Journals (Sweden)

    Ismail Nurulisma

    2018-01-01

    Full Text Available Reading is very important to access knowledge. Reading skills starts during preschool level no matter of the types of languages. At present, there are many preschool children who are still unable to recognize letters or even words. This leads to the difficulties in reading. Therefore, there is a need of intervention in reading to overcome such problems. Thus, technologies were adapted in enhancing learning skills, especially in learning to read among the preschool children. Phonological is one of the factors to be considered to ensure a smooth of transition into reading. Phonological concept enables the first learner to easily learn reading such to learn reading Malay language. The medium of learning to read Malay language can be assisted via the supportive of multimedia technology to enhance the preschool children learning. Thus, an interactive system is proposed via a development of interactive reading Malay language learning system, which is called as I-ReaMaLLS. As a part of the development of I-ReaMaLLS, this paper focus on the development of conceptual framework in developing interactive reading Malay language learning system (I-ReaMaLLS. I-ReaMaLLS is voice based system that facilitates the preschool learner in learning reading Malay language. The conceptual framework of developing I-ReaMaLLS is conceptualized based on the initial study conducted via methods of literature review and observation with the preschool children, aged 5 – 6 years. As the result of the initial study, research objectives have been affirmed that finally contributes to the design of conceptual framework for the development of I-ReaMaLLS.

  7. Selenium supplementation for Hashimoto's thyroiditis.

    Science.gov (United States)

    van Zuuren, Esther J; Albusta, Amira Y; Fedorowicz, Zbys; Carter, Ben; Pijl, Hanno

    2013-06-06

    Hashimoto's thyroiditis is a common auto-immune disorder. The most common presenting symptoms may include anxiety, negative mood, depression, dry skin, cold intolerance, puffy eyes, muscle cramps and fatigue, deep voice, constipation, slow thinking and poor memory. Clinical manifestations of the disease are defined primarily by low levels of thyroid hormones; therefore it is treated by hormone replacement therapy, which usually consists of levothyroxine (LT4). Selenium might reduce antibody levels and result in a decreased dosage of LT4 and may provide other beneficial effects (e.g. on mood and health-related quality of life). To assess the effects of selenium supplementation on Hashimoto's thyroiditis. We searched the following databases up to 2 October 2012: CENTRAL in The Cochrane Library (2012, Issue 10), MEDLINE, EMBASE, and Web of Science; we also screened reference lists of included studies and searched several online trial registries for ongoing trials (5 November 2012). Randomised controlled clinical trials that assessed the effects of selenium supplementation for adults diagnosed with Hashimoto's thyroiditis. Study selection, data extraction, assessment of risk of bias, and analyses were carried out by two independent review authors. We assessed the quality of the evidence of included studies using GRADE. We were unable to conduct a meta-analysis because clinical heterogeneity between interventions that were investigated is substantial. Four studies at unclear to high risk of bias comprising 463 participants were included. The mean study duration was 7.5 months (range 3 to 18 months). One of our primary outcomes-'change from baseline in health related quality of life'-and two of our secondary outcomes-'change from baseline in LT4 replacement dosage at end of the study' and 'economic costs'-were not assessed in any of the studies. One study at high risk of bias showed statistically significant improvement in subjective well-being with sodium

  8. Oral potassium supplementation in surgical patients.

    Science.gov (United States)

    Hainsworth, Alison J; Gatenby, Piers A

    2008-08-01

    Hospital inpatients are frequently hypokalaemic. Low plasma potassium levels may cause life threatening complications, such as cardiac arrhythmias. Potassium supplementation may be administered parenterally or enterally. Oral potassium supplements have been associated with oesophageal ulceration, strictures and gastritis. An alternative to potassium salt tablets or solution is dietary modification with potassium rich food stuffs, which has been proven to be a safe and effective method for potassium supplementation. The potassium content of one medium banana is equivalent to a 12 mmol potassium salt tablet. Potassium supplementation by dietary modification has been shown to be equally efficacious to oral potassium salt supplementation and is preferred by the majority of patients. Subsequently, it is our practice to replace potassium using dietary modification, particularly in surgical patients having undergone oesophagogastrectomy or in those with peptic ulcer disease.

  9. Regional Assessment of Supplementation Project. Status report

    Energy Technology Data Exchange (ETDEWEB)

    1991-10-01

    The Fish and Wildlife Program of the Northwest Power Planning Council (NPPC) prescribes several approaches to achieve its goal of doubling the salmon and steelhead runs of the Columbia River. Among those approaches are habitat restoration, improvements in adult and juvenile passage at dams and artificial propagation. Supplementation will be a major part of the new hatchery programs. The purpose of the Regional Assessment of Supplementation Project (RASP) is to provide an overview of ongoing and planned supplementation activities, to construct a conceptual framework and model for evaluating the potential benefits and risks of supplementation and to develop a plan for better regional coordination of research and monitoring and evaluation of supplementation. RASP has completed its first year of work. Progress toward meeting the first year`s objectives and recommendations for future tasks are contained in this report.

  10. Mineral supplementation in Tunisian smallholder dairy farms

    International Nuclear Information System (INIS)

    Rekhis, J.; Kouki-Chebbi, K.; Dhaouadi, B.; Khlif, K.

    2002-01-01

    The aim of the experiment was to determine the effects of supplementation of di-calcium-phosphate in the form of blocks in late pregnancy (2 months before calving), on production and reproduction parameters of dairy cattle in smallholder farms. The experiment covered 63 animals in 20 smallholder farms, divided into control and supplemented groups. Results showed that mineral supplementation had a significant effect on calf weight, milk fat content and reproduction parameters. Calves born to cattle supplemented with di-calcium-phosphate were heavier by 1.67 kg than those in the control group. Similarly, the average milk fat content in the supplemented group was 5.6 g/L (P 0.05). (author)

  11. Commercially marketed supplements for bodybuilding athletes.

    Science.gov (United States)

    Grunewald, K K; Bailey, R S

    1993-02-01

    We conducted a survey of 624 commercially available supplements targeted towards bodybuilding athletes. Over 800 performance claims were made for these supplements. Supplements include amino acids, boron, carnitine, choline, chromium, dibencozide, ferulic acid, gamma oryzanol, medium chain triglycerides, weight gain powders, Smilax compounds and yohimbine. Many performance claims advertised were not supported by published research studies. In some instances, we found no research to validate the claims; in other cases, research findings were extrapolated to inappropriate applications. For example, biological functions of some non-essential compounds were interpreted as performance claims for the supplements. Claims for others were based on their ability to enhance hormonal release or activity. We suggest that more research be conducted on this group of athletes and their nutritional needs. Furthermore, the effectiveness and safety of supplements merit further investigation.

  12. Maíz: Alimento fundamental en las tradiciones y costumbres mexicanas

    OpenAIRE

    José de Jesús Cuevas Mejía

    2014-01-01

    El siguiente trabajo busca recalcar la importancia del maíz para el pueblo mexicano, que con el paso de los años ha logrado mantener su identidad no en vano por la fuerza y majestuosidad de sus tradiciones y costumbres. Es cierto que hoy en día es la base de la alimentación de muchas familias a lo largo del territorio de México, en cada hogar a la hora del almuerzo, la comida e incluso la merienda, el maíz está presente en una gran variedad de formas, texturas y colores. Esto nos hace pensar ...

  13. Vietnam Inbound M&A Activity: The Role of Government Policy and Regulatory Environment

    Directory of Open Access Journals (Sweden)

    Jamshid C. Hosseini

    2017-05-01

    Full Text Available With a robust recent history of reform and opening, joining of the World Trade Organization, and negotiating a myriad of regional and global trade agreements, Vietnam has emerged as a promising destination for foreign direct investment(FDI and cross-border mergers and acquisitions (M&A. In this paper, we providean overview of Vietnam’s inbound mergers and acquisitions and review the twomain driving forces of inbound M&A, which are the legal framework reformprocess and the equitization of State-owned enterprises. We close by providingdirections for future research in the area of cross-border M&As.

  14. Non-economic determinants of structural transformations in Małopolska agriculture

    Directory of Open Access Journals (Sweden)

    Maciej Basaj

    2009-01-01

    Full Text Available In the article results of the research conducted in 2008 among farmers in two districts located in northern part of the Małopolska voivodeship have been presented. The aim of the article is the presentation of farmers’ opinions and attitudes against accomplishing structural alternations in their vicinity. Getting to know farmers’ intentions against the future of their farms, and also getting to know their estimations about the future of their farms in the vicinity can have particular significance in the prognosis and program of further development of rural areas – especially in such a region, with a big agrarian overpopulation as the Małopolska.

  15. Reconstruction of Northeast Asian Deformation Integrated with Western Pacific Plate Subduction since 200 Ma

    Science.gov (United States)

    Liu, S.; Gurnis, M.; Ma, P.; Zhang, B.

    2017-12-01

    The configuration and kinematics of continental deformation and its marginal plate tectonics on the Earth's surface are intrinsic manifestations of plate-mantle coupling. The complex interactions of plate boundary forces result in plate motions that are dominated by slab pull and ridge push forces and the effects of mantle drag; these interactions also result in continental deformation with a complex basin-mountain architecture and evolution. The kinematics and evolution of the western Pacific subduction and northeast Asian continental-margin deformation are a first-order tectonic process whose nature and chronology remains controversial. This paper implements a "deep-time" reconstruction of the western Pacific subduction, continental accretion or collision and basin-mountain deformation in northeast Asia since 200 Ma based on a newly revised global plate model. The results demonstrate a NW-SE-oriented shortening from 200-137 Ma, a NWW-SEE-oriented extension from 136-101 Ma, a nearly N-S-oriented extension and uplift with a short-term NWW-SEE-oriented compressional inversion in northeast China from 100-67 Ma, and a NW-SE- and nearly N-S-oriented extension from 66 Ma to the present day. The western Pacific oceanic plate subducted forward under East Asia along Mudanjiang-Honshu Island during the Jurassic, and the trenches retreated to the Sikhote-Alin, North Shimanto, and South Shimanto zones from ca. 137-128 Ma, ca. 130-90 Ma, and in ca. 60 Ma, respectively. Our time-dependent analysis of plate motion and continental deformation coupling suggests that the multi-plate convergent motion and ocean-continent convergent orogeny were induced by advance subduction during the Jurassic and earliest Cretaceous. Our analysis also indicates that the intra-continent rifting and back-arc extension were triggered by trench retreat during the Cretaceous and that the subduction of oceanic ridge and arc were triggered by trench retreat during the Cenozoic. Therefore, reconstructing

  16. Limbic encephalitis and antibodies to Ma2: a paraneoplastic presentation of breast cancer.

    Science.gov (United States)

    Sutton, I; Winer, J; Rowlands, D; Dalmau, J

    2000-08-01

    A patient with atypical medullary breast cancer is described who presented with symptoms of limbic encephalitis. The patient's serum and CSF contained antibodies that reacted with the nervous system and the tumour. These antibodies recognised Ma2, a neuronal protein related to paraneoplastic limbic and brainstem encephalitis in men with testicular tumours. This report highlights the importance of testing for paraneoplastic antineuronal antibodies in cases of unexplained limbic encephalitis and suggests screening for breast cancer in women with antibodies predominantly directed to Ma2.

  17. Teaching NeuroImages: Ma2 encephalitis presenting as acute panhypopituitarism in a young man.

    Science.gov (United States)

    Bergner, Caroline G; Lang, Christine; Spreer, Annette; Bähr, Mathias; Mohr, Alexander; Simons, Mikael

    2013-11-05

    A 21-year-old man presented with headache, hypotonia, hypothermia, and somnolence, deteriorating to a Glasgow Coma Scale score of 3 within days. Hormonal testing revealed panhypopituitarism. His cerebral MRI showed a gadolinium-enhancing lesion in the pituitary gland with adjacent changes to the hypothalamus, midbrain, and basal ganglia (figures 1 and 2). Therapy with prednisolone resulted in rapid improvement. Ma2 antibodies were found in the patient's serum and CSF. FDG-PET demonstrated a tumor mass in the superior mediastinum and histology revealed a mediastinal seminoma. Ma2 antibody-mediated paraneoplastic disease has to be considered as a rare differential diagnosis in patients presenting with acute panhypopituitarism.(1.)

  18. Identification of AR(I)MA processes for modelling temporal correlations of GPS observations

    Science.gov (United States)

    Luo, X.; Mayer, M.; Heck, B.

    2009-04-01

    In many geodetic applications observations of the Global Positioning System (GPS) are routinely processed by means of the least-squares method. However, this algorithm delivers reliable estimates of unknown parameters und realistic accuracy measures only if both the functional and stochastic models are appropriately defined within GPS data processing. One deficiency of the stochastic model used in many GPS software products consists in neglecting temporal correlations of GPS observations. In practice the knowledge of the temporal stochastic behaviour of GPS observations can be improved by analysing time series of residuals resulting from the least-squares evaluation. This paper presents an approach based on the theory of autoregressive (integrated) moving average (AR(I)MA) processes to model temporal correlations of GPS observations using time series of observation residuals. A practicable integration of AR(I)MA models in GPS data processing requires the determination of the order parameters of AR(I)MA processes at first. In case of GPS, the identification of AR(I)MA processes could be affected by various factors impacting GPS positioning results, e.g. baseline length, multipath effects, observation weighting, or weather variations. The influences of these factors on AR(I)MA identification are empirically analysed based on a large amount of representative residual time series resulting from differential GPS post-processing using 1-Hz observation data collected within the permanent SAPOS® (Satellite Positioning Service of the German State Survey) network. Both short and long time series are modelled by means of AR(I)MA processes. The final order parameters are determined based on the whole residual database; the corresponding empirical distribution functions illustrate that multipath and weather variations seem to affect the identification of AR(I)MA processes much more significantly than baseline length and observation weighting. Additionally, the modelling

  19. Complementarity in dietary supplements and foods: are supplement users vegetable eaters?

    Science.gov (United States)

    Kang, Hyoung-Goo; Joo, Hailey Hayeon; Choi, Kyong Duk; Lee, Dongmin; Moon, Junghoon

    2017-01-01

    Background : The consumption of fruits, vegetables, and dietary supplements correlate. Most previous studies have aimed to identify the determinants of supplement uses or the distinct features of supplement users; this literature lacks a discussion on dietary supplement consumption as a predictor of fruit and vegetable consumption. Objective : This study examines how dietary supplement consumption correlates with fruit and vegetable consumption by combining scanner data and surveys of Korean household grocery shopping. Methods : Propensity score matching (PSM) is used to identify the relationship between dietary supplement consumption and fruit and vegetable consumption in a household. A logit regression using supplement consumption as the dependent variable is used. Then, the supplement takers (the treatment group) are matched with non-takers (the control group) based on the propensity scores estimated in the logit regression. The fruit and vegetable consumption levels of the groups are then compared. Results : We found that dietary supplement use is associated with higher fruit and vegetable consumption. This supports the health consciousness hypothesis based on attention bias, availability heuristics, the focusing effect, and the consumption episode effect. It rejects the health substitute hypothesis based on economic substitutes and mental accounting. Conclusions : Future research on the health benefits of dietary supplements should address the complementary consumption of fruits/vegetables and their health benefits to avoid misstating the health effects of supplements.

  20. HERBAL SUPPLEMENTS: CAUSE FOR CONCERN?

    Directory of Open Access Journals (Sweden)

    Paolo Borrione

    2008-12-01

    Full Text Available More than 1400 herbal products or herbal-derived compounds are commonly commercialised for health uses worldwide (Tyler, 1996. Herbs are considered dietary supplements, and therefore are subjected to a very limited form of regulation, and advertisements normally highlight their potential activities without mentioning any side effect. Also, herbs are generally believed to be 'natural', and hence safe. Many nutritional supplements contains herb compounds usually not present in the diet (e.g. Ginko biloba, horse- chestnut, and only 10% of the herbs used in nutritional supplements are commonly present in the food (e.g. garlic, soy, blueberry, green the, ginger, curcuma (Eisenberg et al., 1993. There is much interest in "alternative natural approaches" in sport. It is appealing for athletes to use 'natural' substances with similar activity to 'pharmacological' ones in term of improving performance, are not considered doping, and are considered side-effects free (Table 1. Indeed, many herbal dietary supplements marketed on internet are presented as legal alternative to illicit drugs (Denneey et al., 2005. EcdysteroidsEcdysteroids are the steroid hormones of arthropods (Figure 1. They also occur in some plants, where they are known as phytoecdysteroids, and are believed to contribute to deter invertebrate predators. In insects, they regulate moulting and metamorphosis, may regulate reproduction and diapause. Most actions of ecdysteroids are mediated by intracellular receptor complexes, which regulate gene expression in a tissue- and development-specific manner (Lehmann et al 1989.Several phytoecdysteroids have anabolic growth-promoting effects on mice, rats, pigs and Japanese quails. Ecdysteroids stimulate muscle growth, and this anabolic effect promotes increased physical performance without training. Ecdysteroids are also able to increase muscle ATP content in vitamin D-deprived rats (Báthori, 2002. Ecdysteroids stimulate protein synthesis in the