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Sample records for superficial patch system

  1. Superficial siderosis in the central nervous system

    Energy Technology Data Exchange (ETDEWEB)

    Pythinen, J. [Oulu Univ. (Finland). Dept. of Diagnostic Radiology; Paeaekkoe, E. [Oulu Univ. (Finland). Dept. of Diagnostic Radiology; Ilkko, E. [Oulu Univ. (Finland). Dept. of Diagnostic Radiology

    1995-02-01

    We describe a rare entity, superficial siderosis of the central nervous system, due to multiple small episodes of subarachnoid haemorrhage from any source. Non-specific neurological findings are associated with deposition of iron-containing pigments in the leptomeninges and superficial layers of the cortex. T2-weighted magnetic resonance imaging demonstrates characteristic low signal in the meninges. (orig.)

  2. Drenaje suplementario del sistema venoso superficial en colgajos pediculados Supplementary drainage of superficial venous system in pedicled flaps

    Directory of Open Access Journals (Sweden)

    A. Fernández García

    2012-06-01

    Full Text Available Los colgajos pediculados pueden sufrir edema y congestión debido a que su drenaje a trevés del sistema venoso superfical es imposible y el flujo hacia el sistema profundo a nivel del pedículo es precario. Esta situación suele evolucionar hacia la necrosis parcial o la pérdida total del colgajo en pocas horas. La apertura del sistema venoso superficial permite el drenaje adecuado de los tejidos transferidos y evita estas complicaciones. Este artículo analiza el papel de las anastomosis microquirúrgicas en el sistema venoso superficial de los colgajos pediculados. Esta técnica permite comunicar el sistema venoso superfical de los tejidos transferidos con el sistema venoso superficial del territorio que rodea al defecto. Presentamos los resultados obtenidos con esta técnica en colgajos de perforante en hélice, colgajos miocutáneos, colgajos neurocutáneos y colgajos fasciograsos volteados.The pedicled flaps can suffer edema and congestion due to the impossibility of drainage toward the superficial venous system and the precarious flow via the deep system at the level of the pedicle. The evolution of this situation is usually partial necrosis or total loss of the flap in a few hours. The opening of the venous superficial system achieves an appropriate drainage of the transfered tissues and avoids these complications. In this article we analyze the role of the microsurgical anastomosis at the level of the superficial venous system of pedicled flaps. This technique allows to communicate the superficial venous system of the transfered tissues with the superficial venous system of the territory around the defect. We report the results with this method in propeller perforator flaps, miocutaneous flaps, neurocutaneous flaps and adipofascial turn over flaps.

  3. Tunable Patch Antennas Using Microelectromechanical Systems

    Science.gov (United States)

    2011-05-11

    wavelength of the desired resonant frequency [1]. (25) To aid in the design process a MATLAB script was written to solve for patch antenna...10–12, the widths of 50 Ω and 112 Ω microstrip lines were calculated using a MATLAB script included as an appendix to this report. The calculated...2009, pp. 50–55. [11] W.L. Stutzman, G.A. Thiele , Antenna Theory and Design, Second Edition, John Wiley & Sons, Inc. (Hoboken, New Jersey), 1998, pp

  4. Polarization Reconfigurable Patch Antenna Using Microelectromechanical Systems (MEMS) Actuators

    Science.gov (United States)

    Simons, Rainee N.; Chun, Donghoon; Katehi, Linda P. B.

    2002-01-01

    The paper demonstrates a nearly square patch antenna integrated with a novel microelectromechanical systems (MEMS) actuator for reconfiguring the polarization. Experimental results demonstrate that at a fixed frequency, the polarization can be reconfigured, from circular to linear.

  5. Recommended Practice for Patch Management of Control Systems

    Energy Technology Data Exchange (ETDEWEB)

    Steven Tom; Dale Christiansen; Dan Berrett

    2008-12-01

    A key component in protecting a nation’s critical infrastructure and key resources is the security of control systems. The term industrial control system refers to supervisory control and data acquisition, process control, distributed control, and any other systems that control, monitor, and manage the nation’s critical infrastructure. Critical Infrastructure and Key Resources (CIKR) consists of electric power generators, transmission systems, transportation systems, dam and water systems, communication systems, chemical and petroleum systems, and other critical systems that cannot tolerate sudden interruptions in service. Simply stated, a control system gathers information and then performs a function based on its established parameters and the information it receives. The patch management of industrial control systems software used in CIKR is inconsistent at best and nonexistent at worst. Patches are important to resolve security vulnerabilities and functional issues. This report recommends patch management practices for consideration and deployment by industrial control systems owners.

  6. Aneurysms of the superficial venous system: classification and treatment

    Directory of Open Access Journals (Sweden)

    Ronald G. Bush

    2014-11-01

    Full Text Available Superficial venous aneurysms are rarely described and they may remain indolent or become the source for pulmonary emboli. A system of classification and treatment protocol according to size and location is proposed. Three hundred thirty patients were evaluated for symptomatic venous disease (C2-C6 over a 2-year period. A proposed designation for venous aneurysm is described. Patients fulfilling this criterion are described in reference to site of involvement, histologic findings, and method of treatment. Five percent of patients met the criteria for venous aneurysm. Nine aneurysms of the greater saphenous vein were identified. Three aneurysms were proximal to the subterminal valve and the rest were distal. Six aneurysms of the anterior accessory greater saphenous vein (AAGSV were identified. Three aneurysms of the AAGSV spontaneously thrombosed. Two patients presented with aneurysms of the small saphenous vein. Histology revealed thickened intima, smooth muscle and adventitia. Aneurysm designation relates to diameter of normal and contiguous vein. All superficial venous aneurysms in close proximity to the junction of the femoral or popliteal vein should be ligated. Classification of venous aneurysms should include the AAGSV, which may present with spontaneous thrombosis.

  7. Lower body lift with superficial fascial system suspension.

    Science.gov (United States)

    Lockwood, T

    1993-11-01

    Multiple body contour deformities of the trunk and thighs are commonly treated in separate stages to limit postoperative complications and disability. Recent advances in the surgical design of the medial thigh lift and the lateral thigh/buttock lift along with an understanding of the functional anatomy of the superficial fascial system have significantly improved results and decreased complications of trunk/thigh lifts. The enhanced safety of current trunk/thigh lifts has allowed new combinations to treat multiple body contour deformities in a single stage. Laxity of the entire lower trunk and thigh regions can be treated in one stage in selected patients. The lower body lift combines the transverse flank/thigh/buttock lift and the fascial anchoring medial thigh lift in one operation. In addition to the expected tightening of the flank, buttocks, and total thighs, this procedure results in a surprising degree of epigastric and hypogastric tightening of mild to moderate abdominal laxity without direct surgical undermining or umbilical transposition. Ten patients having the lower body lift alone or in combination with liposuction and other body contouring procedures were followed for 6 to 24 months. The primary indication for surgery is moderate to severe soft-tissue laxity of the lower trunk and thighs with minimal or mild residual fat deposits. Skin contour irregularities due to skin laxity (cellulite of laxity) or to postliposuction adhesions are frequently present and may be severe. Patients with significant fat deposits may be treated initially with liposuction 3 to 4 months earlier to become candidates for this procedure. Key technical elements of this procedure include (1) both supine and lateral decubitus positioning with the hip flexed and abducted to allow overcorrection, (2) appropriate direct surgical undermining through superficial fascial system zones of adherence in the superior thigh while avoiding the lymphatics of the femoral triangle, (3) more

  8. Transdermal Patches: A Complete Review on Transdermal Drug Delivery System

    Directory of Open Access Journals (Sweden)

    Patel DS

    2012-03-01

    Full Text Available Today about 70% of drugs are taken orally and are found not to be as effective as desired. To improvesuch characters transdermal drug delivery system was emerged. Transdermal drug delivery system(TDDS provides a means to sustain drug release as well as reduce the intensity of action and thusreduce the side effects associated with its oral therapy and differs from traditional topical drug delivery.Transdermal Drug Delivery System is the system in which the delivery of the active ingredients of thedrug occurs by means of skin. Several important advantages of transdermal drug delivery are limitationof hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steadyplasma level of the drug. Various types of transdermal patches are used to incorporate the activeingredients into the circulatory system via skin. This review article covers a brief outline of theprinciples of transdermal permeation, various components of transdermal patch, approaches oftransdermal patch, evaluation of transdermal system, its application with its limitation.

  9. Patched Green's function techniques for two-dimensional systems

    DEFF Research Database (Denmark)

    Settnes, Mikkel; Power, Stephen; Lin, Jun

    2015-01-01

    We present a numerically efficient technique to evaluate the Green's function for extended two-dimensional systems without relying on periodic boundary conditions. Different regions of interest, or “patches,” are connected using self-energy terms which encode the information of the extended parts...... of the system. The calculation scheme uses a combination of analytic expressions for the Green's function of infinite pristine systems and an adaptive recursive Green's function technique for the patches. The method allows for an efficient calculation of both local electronic and transport properties, as well...... as the inclusion of multiple probes in arbitrary geometries embedded in extended samples. We apply the patched Green's function method to evaluate the local densities of states and transmission properties of graphene systems with two kinds of deviations from the pristine structure: bubbles and perforations...

  10. A Modified E Shaped Patch Antenna For Mimo Systems

    Directory of Open Access Journals (Sweden)

    K. Jagadeesh Babu

    2010-10-01

    Full Text Available A compact E shaped patch antenna is proposed in the present work, which can be used for Multiple Input Multiple output (MIMO systems. The modified E shaped patch antenna proposed in this paper offers improved directivity, bandwidth, and return loss characteristics compared to normal E shaped antenna. The antenna system resonates at 5.36GHz and 5.89GHz frequencies for VSWR≤2 which can be used for WiMAX (Wireless interoperability for microwave access applications. The simulation results of return loss, VSWR, gain and radiation pattern are presented.

  11. High-lateral-tension abdominoplasty with superficial fascial system suspension.

    Science.gov (United States)

    Lockwood, T

    1995-09-01

    Modern abdominoplasty techniques were developed in the 1960s. The advent of liposuction has reduced the need for classic abdominoplasty and allowed more aesthetic sculpting of the entire trunk. However, the combination of significant truncal liposuction and classic abdominoplasty is not recommended due to the increased risk of complications. Although the surgical principles of classic abdominoplasty certainly have stood the test of time, they are based on two theoretical assumptions that may be proved to be inaccurate. The first assumption is that wide direct undermining to costal margins is essential for abdominal flap advancement. In fact, discontinuous undermining allows effective loosening of the abdominal flap while preserving vascular perforators. The second inaccurate assumption is that with aging and weight fluctuations (including pregnancy), abdominal skin relaxation occurs primarily in the vertical direction from the xiphoid to the pubis. This is true in the lower abdomen, but in most patients a strong superficial fascial system adherence to the linea alba in the epigastrium limits vertical descent. Epigastric laxity frequently results from a progressive horizontal loosening due to relaxation of the tissue along the lateral trunk. Experience with the lower-body lift procedure has shown that significant lateral truncal skin resection results in epigastric tightening. In these patients, the ideal abdominoplasty pattern would resect as much or more laterally than centrally, leading to more natural abdominal contours. Fifty patients who underwent high-lateral-tension abdominoplasty with and without significant truncal liposuction and other aesthetic procedures were followed for 4 to 16 months. The primary indication for surgery was moderate to severe laxity of abdominal skin and muscle with or without truncal fat deposits. Complication rates were equal to or less than those of historical controls and did not increase with significant adjunctive liposuction

  12. Microelectromechanical Systems (MEMS) Actuator for Reconfigurable Patch Antenna Demonstrated

    Science.gov (United States)

    Simons, Rainee N.

    2001-01-01

    A microstrip patch antenna with two contact actuators along the radiating edges for frequency reconfiguration was demonstrated at K-band frequencies. The layout of the antenna is shown in the following figure. This antenna has the following advantages over conventional semiconductor varactor-diode-tuned patch antennas: 1. By eliminating the semiconductor diode and its nonlinear I-V characteristics, the antenna minimizes intermodulation signal distortion. This is particularly important in digital wireless systems, which are sensitive to intersymbol interference caused by intermodulation products. 2. Because the MEMS actuator is an electrostatic device, it does not draw any current during operation and, hence, requires a negligible amount of power for actuation. This is an important advantage for hand-held, battery-operated, portable wireless systems since the battery does not need to be charged frequently. 3. The MEMS actuator does not require any special epitaxial layers as in the case of diodes and, hence, is cost effective.

  13. Pentagonal shaped microstrip patch antenna in wireless capsule endoscopy system

    Directory of Open Access Journals (Sweden)

    Bondili Kohitha Bai

    2012-01-01

    Full Text Available Wireless capsule endoscopy is a best option for exploring inaccessible areas of small intestine for inspection of gastrointestinal tract. This technique brings less pain compare to conventional endoscopy technique. The wireless endoscopy system comprises of three main modules: an ingestible capsule that is swallowed by the patient, an external control unit and display device for image display. In this paper we proposed pentagonal shape microstrip patch antenna for wireless capsule endoscopy system. Inhibiting characteristics of a single microstrip patch like low gain, light weight, thin thickness and smaller bandwidth, make it more popular. This kind of antenna is aggressive miniaturized to meet the requirements of the wireless capsule endoscope. The simulation results show that the designed Circular Polarization (CP pentagonal shaped microstrip patch antenna gives axial ratio of 0.6023 at 2.38 GHz and CP axial ratio bandwidth of 36MHz with 1.5%. The antenna designed for wireless capsule endoscopy is a proposed one, which may work effectively when compared to other antennas in the capsule.

  14. An improved MRI guided ultrasound system for superficial tumor hyperthermia

    Science.gov (United States)

    Zhu, Mengyuan; Shen, Guofeng; Su, Zhiqiang; Chen, Sheng; Wu, Hao

    2017-03-01

    Among many methods in tumor treatment, ultrasound hyperthermia is characterized by non-invasiveness, and it has been proven very effective for clinical treatment. But the problem of monitoring temperature limits its development. MRI-based temperature mapping techniques are safe compared with invasive methods and have been applied to detect temperature changes for a variety of applications. Among these techniques, the proton resonance frequency (PRF) method is relatively advanced. With a temperature measuring experiment and experiment conducted on tumors inside rabbit legs, the effectiveness of PRF method has been proved. This paper is to introduce an MRI guided ultrasound superficial tumor hyperthermia instrument based on PRF method.

  15. Superficial siderosis of the central nervous system due to chronic hemorrhage from a giant invasive prolactinoma.

    Science.gov (United States)

    Steinberg, Jacob; Cohen, José E; Gomori, John M; Fraifeld, Shifra; Moscovici, Samuel; Rosenthal, Guy; Shoshan, Yigal; Itshayek, Eyal

    2013-07-01

    Superficial siderosis of the central nervous system (CNS) is a rare disorder caused by deposition of hemosiderin in neuronal tissue in the subpial layer of the CNS due to slow subarachnoid or intraventricular hemorrhage. The most common neurologic manifestations include progressive gait ataxia, sensorineural hearing loss, and corticospinal tract signs. We present a case of superficial siderosis in a 43-year-old man who presented to the Emergency Department with sudden onset bilateral visual deterioration and a loss of consciousness. A hemorrhagic giant prolactinoma was diagnosed based on brain CT scan, T1-weighted MRI, and an endocrine blood examination. Susceptibility-weighted non-contrast MRI showed pathognomonic signs of superficial siderosis in the form of a hypointensity rim surrounding the brainstem, cerebellar fissures, and cranial nerves VII and VIII. This report demonstrates that superficial siderosis can be caused by pituitary apoplexy. Copyright © 2012 Elsevier Ltd. All rights reserved.

  16. Jellyfish Patch Detecting Using Low Latitude Remote Sensing System

    Science.gov (United States)

    Lee, J. S.; Jo, Y. H.

    2015-12-01

    Jellyfish can be asexual and sexual reproduction depending on the environment, and it has excellent environmental adaptability and reproduction than other sea creatures. If the marine environment become worse, jellyfish can take advantage in the competition for survival. Marine environmental changes caused by rapid climate change, dyke construction and land reclamation will increase the amount of jellyfish and as a result can lead to a various social and economic problems. In this study, jellyfish were observed in coastal area using a low-altitude Helikite remote sensing system for the first time. Helikite is a type of helium balloon plus a kite that can get the data with optical sensors for the desired spatial resolutions by adjusting the altitudes. In addition, it has an advantage that can monitor any objects for a long time at one place as long as the electric power and helium last. In this study, we observed the jellyfish patches using a digital camera in the Chesapeake Bay and estimate populations and size of jellyfish patches through image processing. Research results suggests that we can have long-term real-time observations for not only jellyfish, but also other harmful marine creatures.

  17. Superficial siderosis of the central nervous system secondary to spinal ependymoma.

    Science.gov (United States)

    Pikis, Stylianos; Cohen, José E; Vargas, Andres A; Gomori, J Moshe; Harnof, Sagi; Itshayek, Eyal

    2014-11-01

    Superficial siderosis of the central nervous system is a syndrome caused by deposition of hemosiderin in the subpial layers of the central nervous system, occurring as a result of recurrent asymptomatic or symptomatic bleeding into the subarachnoid space. We report a rare case of superficial siderosis in a 33-year-old man who presented with sensorineural hearing loss. The diagnosis of superficial siderosis on MRI brain studies led to further investigations with detection of a spinal ependymoma at L1-L2, compressing the cauda equina. Gross total resection of the tumor arrested the progression of the neurological deterioration. Our report underlies the importance of early diagnosis and surgical management, with imaging examination of the full neuroaxis to identify the source of bleeding, to halt disease progression and improve prognosis.

  18. Superficial fascial system repair: an abdominoplasty technique to reduce local complications after caesarean delivery.

    Science.gov (United States)

    Al-Benna, Sammy; Al-Ajam, Yazan; Tzakas, Elias

    2009-05-01

    Abdominal incision complications are a major source of morbidity after caesarean delivery. Repair of the superficial fascial system may avert local complications after caesarean delivery by minimising tension to the skin and increasing the initial biomechanical strength of wound which has the potential to decrease early wound dehiscence and as a by-product correct suprapubic bulging.

  19. Management of Control System Information SecurityI: Control System Patch Management

    Energy Technology Data Exchange (ETDEWEB)

    Quanyan Zhu; Miles McQueen; Craig Rieger; Tamer Basar

    2011-09-01

    The use of information technologies in control systems poses additional potential threats due to the frequent disclosure of software vulnerabilities. The management of information security involves a series of policy-making on the vulnerability discovery, disclosure, patch development and patching. In this paper, we use a system approach to devise a model to understand the interdependencies of these decision processes. In more details, we establish a theoretical framework for making patching decision for control systems, taking into account the requirement of functionability of control systems. We illustrate our results with numerical simulations and show that the optimal operation period of control systems given the currently estimated attack rate is roughly around a half a month.

  20. Drenaje suplementario del sistema venoso superficial en colgajos pediculados Supplementary drainage of superficial venous system in pedicled flaps

    OpenAIRE

    Fernández García,A.; C. Fernández Pascual; R.A. Moreno Villalba; Ll. Gerrero Navarro

    2012-01-01

    Los colgajos pediculados pueden sufrir edema y congestión debido a que su drenaje a trevés del sistema venoso superfical es imposible y el flujo hacia el sistema profundo a nivel del pedículo es precario. Esta situación suele evolucionar hacia la necrosis parcial o la pérdida total del colgajo en pocas horas. La apertura del sistema venoso superficial permite el drenaje adecuado de los tejidos transferidos y evita estas complicaciones. Este artículo analiza el papel de las anastomosis microqu...

  1. Failure analysis and surety design of composite patching systems.

    Energy Technology Data Exchange (ETDEWEB)

    Hamoush, Sameer (North Carolina A& T State University, Greensboro, NC)

    2004-08-01

    This work presents an experimental evaluation of patch repair of solid laminated composites. The study was focused on destructive and nondestructive tests of full-scale repaired panels under static tension loading conditions. The testing program consisted of ten panels: three pristine, three damaged, three repaired and one repaired with mismatched fiber orientation patch. The evaluated panels were (300 mm x 675 mm) in size and consisted of 6-ply ((-60 /60/0){sub s}) quasi-isotropic laminates. The destructive tests were performed by North Carolina A&T State University and the nondestructive tests were performed by Iowa State University using Pulse-echo C-scan, Air coupled TTU and Auto-Tap. Sandia National Laboratories validated the NDT tests by implementing NDE field methods. Based on the evaluation performed in this study, it appears that the patch repair is an effective means in retrofitting damaged solid composite laminates.

  2. The superficial musculo-aponeurotic system (SMAS) in the parotid and cheek area.

    Science.gov (United States)

    Mitz, V; Peyronie, M

    1976-07-01

    We have investigated the superficial musculo-aponeurotic system (SMAS) in the parotid and cheek areas by anatomical dissections, by radiographs, and by histological sections. The SMAS may be helpful in corrective surgery for facial palsy and during face lifting operations if a retrofascial approach is used. This procedure, safe in the parotid area, can become dangerous in the area anterior to the parotid gland.

  3. Person Tracking System by Fusing Multicues Based on Patches

    Directory of Open Access Journals (Sweden)

    Song Min Jia

    2015-01-01

    Full Text Available A person tracking algorithm by fusing multicues based on patches is proposed to solve the problem of distinguishing person, occlusion, and illumination variations. Kinect is mounted on the robot for providing color images and depth maps. A detector representing a person by using the fusion of multicues based on patches is proposed. The detector divides the person into many patches and then represents each patch by using depth-color histograms and depth-texture histograms. The appearance representation, considering depth, color, and texture information, has powerful discrimination ability to handle the problems of occlusion, illumination changes, and pose variations. Considering the motion of the robot and person, a tracker called motion extended Kalman filter (MEKF is presented to predict the person’s position. The result of the tracker is treated as a candidate sample of the detector, and then the result of the detector is the previous knowledge of the tracker. The detector and tracker supplement each other and improve the tracking performance. To drive the robot towards the given person precisely, a fuzzy based intelligent gear control strategy (FZ-IGS is implemented. Experiments demonstrate that the proposed approach can track a person in a complex environment and have an optimum performance.

  4. PROXY-BASED PATCHING STREAM TRANSMISSION STRATEGY IN MOBILE STREAMING MEDIA SYSTEM

    Institute of Scientific and Technical Information of China (English)

    Liao Jianxin; Lei Zhengxiong; Ma Xutao; Zhu Xiaomin

    2006-01-01

    A mobile transmission strategy, PMPatching (Proxy-based Mobile Patching) transmission strategy is proposed, it applies to the proxy-based mobile streaming media system in Wideband Code Division Multiple Access (WCDMA) network. Performance of the whole system can be improved by using patching stream to transmit anterior part of the suffix that had been played back, and by batching all the demands for the suffix arrived in prefix period and patching stream transmission threshold period. Experimental results show that this strategy can efficiently reduce average network transmission cost and number of channels consumed in central streaming media server.

  5. Characterization of potassium channel modulators with QPatch automated patch-clamp technology: system characteristics and performance

    DEFF Research Database (Denmark)

    Kutchinsky, Jonatan; Friis, Søren; Asmild, Margit

    2003-01-01

    Planar silicon chips with 1-2-microm etched holes (average resistance: 2.04 +/- 0.02 MOmega in physiological buffer, n = 274) have been developed for patch-clamp recordings of whole-cell currents from cells in suspension. An automated 16-channel parallel screening system, QPatch 16, has been...... developed using this technology. A single-channel prototype of the QPatch system was used for validation of the patch-clamp chip technology. We present here data on the quality of patch-clamp recordings and from actual drug screening studies of human potassium channels expressed in cultured cell lines...

  6. Design and in vivo evaluation of a patch system based on thiolated polymers.

    Science.gov (United States)

    Hoyer, Herbert; Greindl, Melanie; Bernkop-Schnürch, Andreas

    2009-02-01

    A new oral patch delivery system has been designed to increase the overall oral bioavailability of drugs within the gastrointestinal tract. The patch system consists of four layered films: a mucoadhesive matrix layer, a water insoluble backing layer, a middle layer and an enteric surface layer. The separation layer between the two matrix layers contained lactose, starch and confectioners' sugar. The matrix layer, exhibiting a diameter of 2.5 mm and a weight of 5 mg, comprised Polycarbophil-cysteine conjugate (49%), fluoresceine isothiocyanate-dextran (26%), glutathione (5%), and mannitol (20%). A standard tablet formulation consisting of the same matrix served as control. Entire fluoresceine isothiocyanate-dextran (FD(4)) was released from the delivery system within 2 h. For in vivo studies patch systems were administered orally to male Sprague-Dawley rats. Maximum FD(4) concentration in blood of the patch system was 46.1 +/- 8.9 ng/mL and was reached 3 h after administration. In contrast c(max) of control tablets displayed 50.5 +/- 14.9 ng/mL after 2 h and the absorption of FD(4) after administration in oral solution was negligible. The absolute bioavailability of orally administered patch systems and control tablets was 0.54% and 0.32% respectively. Results of this study indicate that a prolonged and higher oral bioavailability of FD(4) is obtained with patches than with tablets.

  7. MATLAB-based automated patch-clamp system for awake behaving mice

    OpenAIRE

    Desai, Niraj S.; Siegel, Jennifer J.; Taylor, William; Chitwood, Raymond A.; Johnston, Daniel

    2015-01-01

    Automation has been an important part of biomedical research for decades, and the use of automated and robotic systems is now standard for such tasks as DNA sequencing, microfluidics, and high-throughput screening. Recently, Kodandaramaiah and colleagues (Nat Methods 9: 585–587, 2012) demonstrated, using anesthetized animals, the feasibility of automating blind patch-clamp recordings in vivo. Blind patch is a good target for automation because it is a complex yet highly stereotyped process th...

  8. A TRIBAND SWASTIKA SHAPED PATCH ANTENNA WITH REDUCED MUTUAL COUPLING FOR WIRELESS MIMO SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    K Jagadeesh Babu; K Sri Ramakrishna; L Pratap Reddy

    2011-01-01

    A novel compact Swastika shaped patch antenna is designed in the present work,which can be used for Multiple Input Multiple Output (MIMO) systems.The proposed two element MIMO system resonates at a triband of 3.3 GHz,5.8 GHz,and 7.1 GHz with an improved impedance bandwidth of 37% and a reduced mutual coupling of -33 dB.These results are better compared to a normal E shaped patch antenna designed with same size and thickness,achieved without using any additional decoupling methods.A 2 × 2 MIMO system employing the Swastika shaped patch antennas is analyzed using computational electromagnetic ray tracing software for an indoor environment.The results show an improvement in the capacity compared to a 2 × 2 MIMO system developed with dipole antennas.The proposed antenna is a good choice for MIMO systems operating for several Ultra WideBand (UWB) applications.

  9. Superficial siderosis of the central nervous system due to brachial plexus injury: a case report; Siderose superficial do sistema nervoso central por lesao do plexo braquial: relato de caso

    Energy Technology Data Exchange (ETDEWEB)

    Setogutti, Enio Tadashi; Cassuriaga, Jefferson; Valduga, Simone Gianella [Fundacao Universitaria de Cardiologia, Porto Alegre, RS (Brazil). Instituto de Cardiologia. Setor de Ressonancia Magnetica]. E-mails: pesquisa@cardiologia.org.br; editoracao-pc@cardiologia.org.br; Lorenzzoni, Pablo Longhi; Severgnini, Giancarlo Muraro [Fundacao Universitaria de Cardiologia, Porto Alegre, RS (Brazil). Instituto de Cardiologia; Feldman, Carlos Jader [Fundacao Universitaria de Cardiologia, Porto Alegre, RS (Brazil). Instituto de Cardiologia. Setor de Radiologia

    2005-10-15

    Superficial siderosis can be caused by hemosiderin deposition o the leptomeninges and subpial layers of the neuro-axis due to recurrent subarachnoid haemorrhage. Probable intrathecal bleeding sites must be investigated. In ut t 50% of the patients the bleeding source may be identified and the progression of the disease can be interrupted. In this study, the authors present a case of superficial siderosis of the central nervous system developed two decades after a traumatic lesion of the brachial plexus.(author)

  10. MATLAB-based automated patch-clamp system for awake behaving mice.

    Science.gov (United States)

    Desai, Niraj S; Siegel, Jennifer J; Taylor, William; Chitwood, Raymond A; Johnston, Daniel

    2015-08-01

    Automation has been an important part of biomedical research for decades, and the use of automated and robotic systems is now standard for such tasks as DNA sequencing, microfluidics, and high-throughput screening. Recently, Kodandaramaiah and colleagues (Nat Methods 9: 585-587, 2012) demonstrated, using anesthetized animals, the feasibility of automating blind patch-clamp recordings in vivo. Blind patch is a good target for automation because it is a complex yet highly stereotyped process that revolves around analysis of a single signal (electrode impedance) and movement along a single axis. Here, we introduce an automated system for blind patch-clamp recordings from awake, head-fixed mice running on a wheel. In its design, we were guided by 3 requirements: easy-to-use and easy-to-modify software; seamless integration of behavioral equipment; and efficient use of time. The resulting system employs equipment that is standard for patch recording rigs, moderately priced, or simple to make. It is written entirely in MATLAB, a programming environment that has an enormous user base in the neuroscience community and many available resources for analysis and instrument control. Using this system, we obtained 19 whole cell patch recordings from neurons in the prefrontal cortex of awake mice, aged 8-9 wk. Successful recordings had series resistances that averaged 52 ± 4 MΩ and required 5.7 ± 0.6 attempts to obtain. These numbers are comparable with those of experienced electrophysiologists working manually, and this system, written in a simple and familiar language, will be useful to many cellular electrophysiologists who wish to study awake behaving mice.

  11. Identification of High Angle Structures Controlling the Geothermal System at Rye Patch, Nevada.

    Science.gov (United States)

    Ehni, W. J.

    2001-12-01

    The successful completion of a recent well in the Rye Patch Geothermal field, located in Pershing County, Nevada, supports the geologic and geophysical interpretation that high angle structures control this geothermal system. Although lower angle structures are present, hot water migrates up from deeper sources along high angle faults more efficiently than structures with a shallower dip. Earlier attempts to develop the resource focused on structures that dipped at an angle between 60 and 70 degrees from horizontal. Recently acquired geophysical data indicated that numerous high angle structures were present in the area, with dips between 80 and 90 degrees. Original drilling targets focused on the subsurface projection of a surface structure, mapped as the Rye Patch fault, with an erroneously low angle. These early attempts at drilling were discouraging and might have been more successful if additional geology and geophysics were used to evaluate the geothermal system and map the Rye Patch fault more accurately. The successful completion of the most recent well can be attributed to the incorporation of the geology of previous wells with additional geology and geophysics. Temperature gradient holes were used to confirm that the Rye Patch fault provided the primary plumbing for this geothermal system, and 3D seismic data indicated that most of the structures had dips between 80 and 90 degrees. Geothermometry at Rye Patch indicates that the resource has a relatively high quartz equilibrium temperature and it is speculated that the higher the angle of the structural control, the higher the resource temperature. The dip of Basin and Range normal faults varies considerably and the interpretation of these structures for geothermal, fossil geothermal mineral prospects, and or oil and gas prospects is important. At Rye Patch, the high angle structure feeds geothermal fluids into cavernous limestone beds, dipping to the west usually between 40 and 60 degrees, which is a

  12. Designing a Signal Conditioning System with Software Calibration for Resistor-feedback Patch Clamp Amplifier.

    Science.gov (United States)

    Hu, Gang; Zhu, Quanhui; Qu, Anlian

    2005-01-01

    In this paper, a programmable signal conditioning system based on software calibration for resistor-feedback patch clamp amplifier (PCA) has been described, this system is mainly composed of frequency correction, programmable gain and filter whose parameters are configured by software automatically to minimize the errors, A lab-designed data acquisition system (DAQ) is used to implement data collections and communications with PC. The laboratory test results show good agreement with design specifications.

  13. Photodynamic therapy: development of a treatment and dosimetry system adapted to superficial tumors of the bladder

    Science.gov (United States)

    Lignon, Dominique; Jaboin, Y.; Wolf, D.; Meunier-Reynes, Anne; Guillemin, Francois H.

    1993-06-01

    Superficial tumors of the bladder or in situ carcinoma could be interesting indications of Photodynamic Therapy (PDT), since a total mutilating cystectomy could be avoided. The plurifocality of the lesions requires a treatment of the whole mucose; the quantity of light energy must be homogenous and sufficient to induce a therapeutic effect, still non toxic for normal tissues. We therefore developed a system of treatment and intravesical dosimetry control so that the operator can have precise information on the light repartition in the bladder in real time to enable him to optimize the positioning of the irradiation source. This intravesical device consists of twelve light sensors with optical fiber distributed symmetrically against the walls of the bladder; the emitting source is constituted of a scattering isotropic sphere. The signals emitted by the sensors are converted into tension. The acquisition part of the system values consists of two parts : an analogic part, the values are multiplexed on a same oscilloscope track to see in real time their evolution according to the position of the emitting source. The other part is constituted by the numeric acquisition of values for further analysis. We developed, from a mathematical modelisation of the bladder, a centering program of the diffusor that indicates its position in the bladder, as well as a cartography program where the bladder is re-built by interpolation with the different lighting levels.

  14. Sleep Sleeping Patch

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The Sleep Sleeping Patch is a new kind of external patch based on modern sleep medicine research achievements, which uses the internationally advanced transdermal therapeutic system (TTS). The Sleep Sleeping Patch transmits natural sleep inducers such as peppermint and liquorice extracts and melatonin through the skin to induce sleep. Clinical research proves that the Sleep Sleeping Patch can effectively improve insomnia and the quality of sleep. Highly effective: With the modern TTS therapy,

  15. THE CRITERIA OF ULTIMATE BOUNDEDNESS FOR NONAUTONOMOUS DIFFUSIVE LOTKA-VOLTERRA SYSTEMS IN TWO HETEROGENEOUS PATCHES

    Institute of Scientific and Technical Information of China (English)

    LI Xuezhi; GENI Gupur; ZHU Guangtian

    2001-01-01

    In this paper, a set of sufficient conditions is obtained for the ultimate boundedness of nonautonomous n-species diffusive Lotka-Volterra sub-models in two heterogeneous patches. The sub-models are the Lotka-Volterra tree systems, including the Lotka-Volterra chain systems and the Lotka-Volterra models between one and multispecies. The criteria in this paper are in explicit forms of the parameters and thus are easily verifiable.

  16. Wound tension in rhytidectomy. Effects of skin-flap undermining and superficial musculoaponeurotic system suspension.

    Science.gov (United States)

    Burgess, L P; Casler, J D; Kryzer, T C

    1993-02-01

    This study was conducted to determine the effects of skin-flap undermining and superficial musculoaponeurotic system (SMAS) suspension on wound-closing tension. Nine sides from five fresh-frozen cadavers were used, with closing tension measured at the two main anchor points, anteriorly (A) and posteriorly (P), with and without SMAS plication for minimal (MIN), intermediate (INT), and maximal (MAX) skin-flap undermining. Results indicated that closing tension was significantly decreased with SMAS plication, both A and P, for all three levels of skin undermining. The average decrease in closing tension with SMAS plication was: A-MIN 191 g, A-INT 95 g, A-MAX 83 g, P-MIN 235 g, P-INT 68 g, and P-MAX 70 g (P tension decreased with wider skin-flap undermining, both with and without SMAS plication. The tension-reducing effect of SMAS plication was decreased with wider skin-flap undermining. Regression analysis determined a second-order exponential curve relating closing tension to skin excision.

  17. Development of the Platysma Muscle and the Superficial Musculoaponeurotic System (Human Specimens at 8–17 Weeks of Development

    Directory of Open Access Journals (Sweden)

    C. De la Cuadra-Blanco

    2013-01-01

    Full Text Available There is controversy regarding the description of the different regions of the face of the superficial musculoaponeurotic system (SMAS and its relationship with the superficial mimetic muscles. The purpose of this study is to analyze the development of the platysma muscle and the SMAS in human specimens at 8–17 weeks of development using an optical microscope. Furthermore, we propose to study the relationship of the anlage of the SMAS and the neighbouring superficial mimetic muscles. The facial musculature derives from the mesenchyme of the second arch and migrates towards the different regions of the face while forming premuscular laminae. During the 8th week of development, the cervical, infraorbital, mandibular, and temporal laminae are observed to be on the same plane. The platysma muscle derives from the cervical lamina and its mandibular extension enclosing the lower part of the parotid region and the cheek, while the SMAS derives from the upper region. During the period of development analyzed in this study, we have observed no continuity between the anlage of the SMAS and that of the superficial layer of the temporal fascia and the zygomaticus major muscle. Nor have we observed any structure similar to the SMAS in the labial region.

  18. Development of the Platysma Muscle and the Superficial Musculoaponeurotic System (Human Specimens at 8–17 Weeks of Development)

    Science.gov (United States)

    De la Cuadra-Blanco, C.; Peces-Peña, M. D.; Carvallo-de Moraes, L. O.; Herrera-Lara, M. E.; Mérida-Velasco, J. R.

    2013-01-01

    There is controversy regarding the description of the different regions of the face of the superficial musculoaponeurotic system (SMAS) and its relationship with the superficial mimetic muscles. The purpose of this study is to analyze the development of the platysma muscle and the SMAS in human specimens at 8–17 weeks of development using an optical microscope. Furthermore, we propose to study the relationship of the anlage of the SMAS and the neighbouring superficial mimetic muscles. The facial musculature derives from the mesenchyme of the second arch and migrates towards the different regions of the face while forming premuscular laminae. During the 8th week of development, the cervical, infraorbital, mandibular, and temporal laminae are observed to be on the same plane. The platysma muscle derives from the cervical lamina and its mandibular extension enclosing the lower part of the parotid region and the cheek, while the SMAS derives from the upper region. During the period of development analyzed in this study, we have observed no continuity between the anlage of the SMAS and that of the superficial layer of the temporal fascia and the zygomaticus major muscle. Nor have we observed any structure similar to the SMAS in the labial region. PMID:24396304

  19. Combined Calibration Method and its Realization for Direction Finding Antenna Systems with Patch Antennas

    Directory of Open Access Journals (Sweden)

    R. Seller

    2007-09-01

    Full Text Available A novel radio channel compensation method aiming to give optimal calibration for microstrip antenna array systems is presented in this paper, realized for an actual DOA measurement antenna system using microstrip antennas to sample the electromagnetic field, operating at 4.5GHz. This new approach considers mismatch between antennas and channel RF ports, channel transmission inequalities, and also decreases the effects of multipath propagation components of calibration reference signals by placing the calibration reference signal feeding network on the microstrip antenna array bearer, directly beside the antenna patches. It is combined with orthogonal spread spectrum calibration signal utility for continuous uninterrupted measurements. The spread spectrum calibration signal is orthogonal to the continuous wave (CW signal to be measured, therefore, the 2 signals can be separated in the receiver, enabling them to be present simultaneously. DOA measurement results are shown, measured with the realized integrated microstrip patch antenna array with calibration network hardware.

  20. The role of habitat patches on mammalian diversity in cork oak agroforestry systems

    Science.gov (United States)

    Rosalino, Luis M.; Rosário, João do; Santos-Reis, Margarida

    2009-07-01

    Habitat patches, depending on the degree of differentiation from the matrix, can add few or many elements to the species pool of a particular landscape. Their importance to biodiversity is particularly relevant in areas with complex landscapes, where natural, naturalized, or managed habitats are interspersed by small patches of habitat types with very different biophysical characteristics; e.g., fruit orchards and riparian areas. This is the case of the montado landscape, a cork oak agroforestry system that largely covers south-western Portugal. We evaluated whether the high mammalian biodiversity found in this system is, in part, the cumulative result of the species found in the non-matrix habitats. Our results indicate that in areas where there are inclusions of orchards/olive yards and riparian vegetation in the cork oak woodland, a significantly higher number of mammalian species are present. We further detected a positive effect of low human disturbance on mammal diversity. Ultimately, our results can be used by managers to augment their management options, since we show that the inclusion and maintenance of non-matrix habitat patches in cork oak agro-silvo-forestry systems can help to maximize mammal biodiversity without compromising services associated with agriculture and forestry.

  1. Characterization of potassium channel modulators with QPatch automated patch-clamp technology: system characteristics and performance.

    Science.gov (United States)

    Kutchinsky, Jonatan; Friis, Søren; Asmild, Margit; Taboryski, Rafael; Pedersen, Simon; Vestergaard, Ras K; Jacobsen, Rasmus B; Krzywkowski, Karen; Schrøder, Rikke L; Ljungstrøm, Trine; Hélix, Nathalie; Sørensen, Claus B; Bech, Morten; Willumsen, Niels J

    2003-10-01

    Planar silicon chips with 1-2-microm etched holes (average resistance: 2.04 +/- 0.02 MOmega in physiological buffer, n = 274) have been developed for patch-clamp recordings of whole-cell currents from cells in suspension. An automated 16-channel parallel screening system, QPatch 16, has been developed using this technology. A single-channel prototype of the QPatch system was used for validation of the patch-clamp chip technology. We present here data on the quality of patch-clamp recordings and from actual drug screening studies of human potassium channels expressed in cultured cell lines. Using Chinese hamster ovary (CHO) and human embryonic kidney cells (HEK), gigaseals of 4.1 +/- 0.4 GOmega (n = 146) and high-quality whole-cell current recordings were obtained from hERG and KCNQ4 potassium channels. Success rates for gigaseal recordings varied from 40 to 95%, and 67% of the whole-cell configurations lasted for >20 min. Cells were maintained in suspension up to 4 h in a cell storage facility that is integrated in the QPatch 16. No decline in patchability was observed during this time course. A series of screens was conducted with known inhibitors of the hERG and KCNQ4 potassium channels. Dose-response relationship characterizations of verapamil and rBeKm-1 blockage of hERG currents provided IC(50) values similar to values reported in the literature.

  2. Design and analysis of a conformal patch antenna for a wearable breast hyperthermia treatment system

    Science.gov (United States)

    Curto, Sergio; Ramasamy, Manoshika; Suh, Minyoung; Prakash, Punit

    2015-03-01

    To overcome the limitations of currently available clinical hyperthermia systems which are based on rigid waveguide antennas, a wearable microwave hyperthermia system is presented. A light wearable system can improve patient comfort and be located in close proximity to the breast, thereby enhancing energy deposition and reducing power requirements. The objective of this work was to design and assess the feasibility of a conformal patch antenna element of an array system to be integrated into a wearable hyperthermia bra. The feasibility of implementing antennas with silver printed ink technology on flexible substrates was evaluated. A coupled electromagnetic-bioheat transfer solver and a hemispheric heterogeneous numerical breast phantom were used to design and optimize a 915 MHz patch antenna. The optimization goals were device miniaturization, operating bandwidth, enhanced energy deposition pattern in targets, and reduced Efield back radiation. The antenna performance was evaluated for devices incorporating a hemispheric conformal groundplane and a rectangular groundplane configuration. Simulated results indicated a stable -10 dB return loss bandwidth of 88 MHz for both the conformal and rectangular groundplane configurations. Considering applied power levels restricted to 15 W, treatment volumes (T>410C) and depth from the skin surface were 11.32 cm3 and 27.94 mm, respectively, for the conformal groundplane configuration, and 2.79 cm3 and 19.72 mm, respectively, for the rectangular groundplane configuration. E-field back-radiation reduced by 85.06% for the conformal groundplane compared to the rectangular groundplane configuration. A prototype antenna with rectangular groundplane was fabricatd and experimentally evaluated. The groundplane was created by printing silver ink (Metalon JS-B25P) on polyethylene terephthalate (PET) film surface. Experiments revealed stable antenna performance for power levels up to 15.3 W. In conclusion, the proposed patch antenna with

  3. [Diffuse superficial siderosis of the central nervous system: four case reports and review of the literature].

    Science.gov (United States)

    Calvo, Marta; de Miguel, Cristina; Pinel, Ana; Ortega, José M; Aladro, Yolanda

    2014-10-16

    Introduccion. La siderosis superficial difusa del sistema nervioso central (SNC) es una rara condicion debida a depositos de hemosiderina en las capas subpiales del cerebro y la medula espinal. La fuente de sangrado cronico o recurrente en el espacio subaracnoideo se detecta solo en un 50% de los casos. Los sintomas mas caracteristicos son ataxia cerebelosa e hipoacusia neurosensorial. Las secuencias eco de gradiente potenciadas en T2 de resonancia magnetica constituyen el metodo diagnostico de eleccion. Casos clinicos. Presentamos cuatro pacientes con siderosis superficial difusa del SNC relacionada con angiopatia amiloide, anticoagulacion oral, schwannoma del VIII par craneal y sin fuente de sangrado conocida en un caso. Dos pacientes desarrollaron ataxia cerebelosa; tres de ellos, episodios recurrentes de alteracion focal neurologica; uno, demencia; y el cuarto es un hallazgo radiologico. No se objetivo progresion clinica durante el seguimiento (2-11 años) en tres de ellos. El paciente con angiopatia amiloide evoluciono a demencia. Conclusiones. Los episodios recurrentes de alteracion focal neurologica son los sintomas mas frecuentes en nuestros casos de siderosis superficial difusa del SNC. La evolucion natural de esta condicion no se conoce bien y puede constituir un hallazgo radiologico.

  4. Dynamical model of binary asteroid systems through patched three-body problems

    Science.gov (United States)

    Ferrari, Fabio; Lavagna, Michèle; Howell, Kathleen C.

    2016-08-01

    The paper presents a strategy for trajectory design in the proximity of a binary asteroid pair. A novel patched approach has been used to design trajectories in the binary system, which is modeled by means of two different three-body systems. The model introduces some degrees of freedom with respect to a classical two-body approach and it is intended to model to higher accuracy the peculiar dynamical properties of such irregular and low gravity field bodies, while keeping the advantages of having a full analytical formulation and low computational cost required. The neighborhood of the asteroid couple is split into two regions of influence where two different three-body problems describe the dynamics of the spacecraft. These regions have been identified by introducing the concept of surface of equivalence (SOE), a three-dimensional surface that serves as boundary between the regions of influence of each dynamical model. A case of study is presented, in terms of potential scenario that may benefit of such an approach in solving its mission analysis. Cost-effective solutions to land a vehicle on the surface of a low gravity body are selected by generating Poincaré maps on the SOE, seeking intersections between stable and unstable manifolds of the two patched three-body systems.

  5. Transient increase in systemic interferences in the superficial layer and its influence on event-related motor tasks: a functional near-infrared spectroscopy study

    Science.gov (United States)

    Nambu, Isao; Ozawa, Takuya; Sato, Takanori; Aihara, Takatsugu; Fujiwara, Yusuke; Otaka, Yohei; Osu, Rieko; Izawa, Jun; Wada, Yasuhiro

    2017-03-01

    Functional near-infrared spectroscopy (fNIRS) is a widely utilized neuroimaging tool in fundamental neuroscience research and clinical investigation. Previous research has revealed that task-evoked systemic artifacts mainly originating from the superficial-tissue may preclude the identification of cerebral activation during a given task. We examined the influence of such artifacts on event-related brain activity during a brisk squeezing movement. We estimated task-evoked superficial-tissue hemodynamics from short source-detector distance channels (15 mm) by applying principal component analysis. The estimated superficial-tissue hemodynamics exhibited temporal profiles similar to the canonical cerebral hemodynamic model. Importantly, this task-evoked profile was also observed in data from a block design motor experiment, suggesting a transient increase in superficial-tissue hemodynamics occurs following motor behavior, irrespective of task design. We also confirmed that estimation of event-related cerebral hemodynamics was improved by a simple superficial-tissue hemodynamic artifact removal process using 15-mm short distance channels, compared to the results when no artifact removal was applied. Thus, our results elucidate task design-independent characteristics of superficial-tissue hemodynamics and highlight the need for the application of superficial-tissue hemodynamic artifact removal methods when analyzing fNIRS data obtained during event-related motor tasks.

  6. Automatic Calibration of Frequency Compensation System in Computer-Controlled Patch-Clamp Amplifier

    Directory of Open Access Journals (Sweden)

    Jun Xion

    2007-01-01

    Full Text Available Computer-controlled patch-clamp amplifier is a digitally controlled analog device used to record the cellular ion channel currents in electrophysiology research. The inherent bandwidth and performance of the headstage is limited by the stray capacitance and distributed capacitance across the feedback resistors. In order to effectively improve the performance of the headstage, the paper advanced a simplified automatic calibration method of frequency compensation system in resistor-feedback patch-clamp amplifier. The dynamic model of headstage was approximate as a two poles and one zero system in the transfer function by experience and test results, so the dynamic characteristics of the headstage were obtained employing least squares parameter estimation algorithm. Further more, the compensation parameter of high frequency booster can be estimated by the time constant of main pole of headstage. And automatic adjustment of the parameters in transient response correction stage was performed as a least squares fitting problem. The software routine running on the host computer conducted all operations of frequency compensation. Experimental results demonstrate that the simplified automatic calibration method can substantially extend the bandwidth and minimize step response error of headstage.

  7. Concentration-Induced Association in a Protein System Caused by a Highly Directional Patch Attraction.

    Science.gov (United States)

    Li, Weimin; Persson, Björn A; Lund, Mikael; Bergenholtz, Johan; Zackrisson Oskolkova, Malin

    2016-09-01

    Self-association of the protein lactoferrin is studied in solution using small-angle X-ray scattering techniques. Effective static structure factors have been shown to exhibit either a monotonic or a nonmonotonic dependence on protein concentration in the small wavevector limit, depending on salt concentration. The behavior correlates with a nonmonotonic dependence of the second virial coefficient on salt concentration, such that a maximum appears in the structure factor at a low protein concentration when the second virial coefficient is negative and close to a minimum. The results are interpreted in terms of an integral equation theory with explicit dimers, formulated by Wertheim, which provides a consistent framework able to explain the behavior in terms of a monomer-dimer equilibrium that appears because of a highly directional patch attraction. Short attraction ranges preclude trimer formation, which explains why the protein system behaves as if it were subject to a concentration-dependent isotropic protein-protein attraction. Superimposing an isotropic interaction, comprising screened Coulomb repulsion and van der Waals attraction, on the patch attraction allows for a semiquantitative modeling of the complete transition pathway from monomers in the dilute limit to monomer-dimer systems at somewhat higher protein concentrations.

  8. An autopsy case of idiopathic superficial hemosiderosis of the central nervous system: a microscopic and immunohistochemical study.

    Science.gov (United States)

    Katsuragi, S; Sakai, T; Watanabe, K; Shimoji, A; Deshimaru, M; Kuramoto, R; Miyamoto, K; Yamashita, K; Miyakawa, T

    1988-01-01

    The brain of a patient with idiopathic superficial hemosiderosis of the central nervous system was examined by light and electron microscopy. A histopathological study revealed massive, symmetrically situated necrosis in the temporal and insular lobes, which has not been described in previous reports. In addition, immunohistochemistry revealed ovoid bodies in the astroglia. Electron microscopy showed that these bodies were composed of fine granules, 50-60 A in diameter, and electron-dense amorphous material. Based on detailed histopathological and ultrastructural findings, the mechanism of ovoid body formation is discussed.

  9. Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator

    Science.gov (United States)

    Okada, Jun-ichi; Yoshinaga, Takashi; Kurokawa, Junko; Washio, Takumi; Furukawa, Tetsushi; Sawada, Kohei; Sugiura, Seiryo; Hisada, Toshiaki

    2015-01-01

    To save time and cost for drug discovery, a paradigm shift in cardiotoxicity testing is required. We introduce a novel screening system for drug-induced arrhythmogenic risk that combines in vitro pharmacological assays and a multiscale heart simulator. For 12 drugs reported to have varying cardiotoxicity risks, dose-inhibition curves were determined for six ion channels using automated patch clamp systems. By manipulating the channel models implemented in a heart simulator consisting of more than 20 million myocyte models, we simulated a standard electrocardiogram (ECG) under various doses of drugs. When the drug concentrations were increased from therapeutic levels, each drug induced a concentration-dependent characteristic type of ventricular arrhythmia, whereas no arrhythmias were observed at any dose with drugs known to be safe. We have shown that our system combining in vitro and in silico technologies can predict drug-induced arrhythmogenic risk reliably and efficiently. PMID:26601174

  10. Design & Analysis of Microstrip Patch Antenna Using Different Dielectric Materials for WiMAX Communication System

    Directory of Open Access Journals (Sweden)

    Md. Moidul Islam

    2016-03-01

    Full Text Available This Paper presents Microstrip patch antenna for WiMAX communication system which operate at 5.8 GHz frequency band. The main objective of this paper is to design and observe the performance of the designed microstrip patch antenna for different dielectric materials. The size of the designed antenna has been also miniaturized. Better performance is observed for FR4 and dupont-951 dielectric material. For FR4 radiation efficiency is-2.776 dB and total efficiency is -3.026 dB at 5.8 GHz, this indicates better performance. And for dupont-951 the return loss is much lower comparing to the other dielectric materials used in this research, which is -16.609 dB. Also for dupont-951 and FR4, VSWR is found 1.35 and 1.7 respectively which is desirable. Also the size of the antenna has been reduced. In this paper we also observed and analyzed the radiation pattern of far field region, gain, radiation efficiency and total efficiency for different dielectric materials.

  11. Produtividade e qualidade fisiológica de sementes de aveia preta em função da calagem superficial em plantio direto = Black oat yield and seed physiologic quality under superficial lime application in no tillage system

    Directory of Open Access Journals (Sweden)

    Tiago Roque Benetoli da Silva

    2006-04-01

    Full Text Available Com o objetivo de avaliar a produtividade e a qualidade fisiológica de sementes de aveia preta em razão da aplicação superficial de calcário em plantio direto, foi realizado um experimento em Botucatu, Estado de São Paulo, sob condições de sequeiro. O delineamento experimental foi o de blocos casualizados, com quatro repetições, em que os tratamentos foram constituídos por aplicação superficial de doses de calcário dolomítico (D0 = zero – sem aplicação de calcário; D1 = 1,8 t ha-1 – quantidade de calcário para elevar a saturação por bases a 54%; D2 = 3,6 t ha-1 – quantidade de calcário para elevar a saturação por bases a 68% e D3 = 5,4 t ha-1 – quantidade de calcário para elevar a saturação por bases a 80%, realizada em outubro de 2002. A cultura da aveia preta, cultivar Comum, foi semeada em abril de 2004, no segundo ano após a rotação milheto (primavera, feijão (verão e aveia preta (outono e inverno. Com os resultados obtidos, observou-se ganho de produtividade com a aplicação superficial de calcário, porém sem influenciar a qualidade fisiológica das sementes de aveia preta.The experiment carried out in Botucatu, São Paulo State, Brazil, in dry conditions, aiming to evaluate the yield and physiologic quality of black oat seeds, under superficial liming in no tillage system. A randomized complete block design was used, with four replications. The treatments were superficial application of different dolomitic lime rates (R0 = zero – without lime; R1 = 1.8 t ha-1 – lime to increase the base saturation at 54%; R2 = 3.6 t ha-1 – lime to increase the base saturation at 68%, and R3 = 5.4 t ha-1 – lime to increase the base saturation at 80%, in October 2002. The blackoat Common cultivar was sowed in April 2004, in second year, after the crop rotation of millet (spring, common bean (summer, black oat (autumn/winter. The results showed that the black oat physiologic quality seed was not affected by

  12. Softness sensor system for simultaneously measuring the mechanical properties of superficial skin layer and whole skin.

    Science.gov (United States)

    Nakatani, Masashi; Fukuda, Toru; Arakawa, Naomi; Kawasoe, Tomoyuki; Omata, Sadao

    2013-02-01

    Few attempts have been made to distinguish the softness of different skin layers, though specific measurement of the superficial layer would be useful for evaluating the emollient effect of cosmetics and for diagnosis of skin diseases. We developed a sensor probe consisting of a piezoelectric tactile sensor and a load cell. To evaluate it, we firstly measured silicone rubber samples with different softness. Then, it was applied to human forearm skin before and after tape-stripping. A VapoMeter and skin-surface hygrometer were used to confirm removal of the stratum corneum. A Cutometer was used to obtain conventional softness data for comparison. Both the piezoelectric tactile sensor and the load cell could measure the softness of silicone rubber samples, but the piezoelectric tactile sensor was more sensitive than the load cell when the reaction force of the measured sample was under 100 mN in response to a 2-mm indentation. For human skin in vivo, transepidermal water loss and skin conductance were significantly changed after tape-stripping, confirming removal of the stratum corneum. The piezoelectric tactile sensor detected a significant change after tape-stripping, whereas the load cell did not. Thus, the piezoelectric tactile sensor can detect changes of mechanical properties at the skin surface. The load cell data were in agreement with Cutometer measurements, which showed no change in representative skin elasticity parameters after tape-stripping. These results indicate that our sensor can simultaneously measure the mechanical properties of the superficial skin layer and whole skin. © 2012 John Wiley & Sons A/S.

  13. System maps for retention of small neutral compounds on a superficially porous particle column in reversed-phase liquid chromatography.

    Science.gov (United States)

    Atapattu, Sanka N; Poole, Colin F; Praseuth, Mike B

    2016-10-14

    The system constants of the solvation parameter model are used to prepare system maps for the retention of small neutral molecules on the ocadecylsiloxane-bonded silica superficially porous particle stationary phase (Kinetex C18) for aqueous-organic solvent mobile phases containing 10-70% (v/v) methanol or acetonitrile. A comparison of the system constants with eight commercially available octadecylsiloxane-bonded silica columns for the same separation conditions confirms that the general retention properties of Kinetex C-18 are similar to totally porous octadecylsiloxane-bonded silica stationary phases and that method transfer should be no more difficult than that usually observed when substituting one octadecylsiloxane-bonded silica column for another.

  14. Permanence and Periodic Solutions for a Two-Patch Impulsive Migration Periodic N-Species Lotka-Volterra Competitive System

    Directory of Open Access Journals (Sweden)

    Zijian Liu

    2015-01-01

    Full Text Available We study a two-patch impulsive migration periodic N-species Lotka-Volterra competitive system. Based on analysis method, inequality estimation, and Lyapunov function method, sufficient conditions for the permanence and existence of a unique globally stable positive periodic solution of the system are established. Some numerical examples are shown to verify our results and discuss the model further.

  15. EXISTENCE OF POSITIVE SOLUTION FOR A TWO—PATCHES COMPETITION SYSTEM WITH DIFFUSION AND TIME DELAY AND FUNCTIONAL RESPONSE

    Institute of Scientific and Technical Information of China (English)

    LiBiwen; ZengXianwu

    2003-01-01

    By using the continuation theorem of coincidence theory,the existence of a positive periodic solution for a two-patches competition system with diffusion and time delay and functional response {x′(t)=x1(t)[a1(t)-b1(t)x1(t)-c1(t)y(t)/[1+m(t)x1(t)

  16. Habitat patch size and mating system as determinants of social group size in coral-dwelling fishes

    Science.gov (United States)

    Thompson, V. J.; Munday, P. L.; Jones, G. P.

    2007-03-01

    It is thought that the size and dispersion of habitat patches can determine the size and composition of animal social groups, however, this has rarely been tested. The relationship between group size, the mating system, and habitat patch size in six species of coral-dwelling gobies was examined. For all species, there was a positive correlation between coral colony size and social group size, however the strength of this relationship varied among species. Paragobiodon xanthosomus exhibited the strongest relationship and a manipulative field experiment confirmed that coral colony size limited group size in this species. For other species including Paragobiodon melanosomus and Eviota bifasciata, either a highly conservative mating system ( P. melanosomus), or increased mobility ( E. bifasciata) appeared to disrupt the relationship between habitat patch size and group size. There was no consistent relationship between the mating system exhibited and group size among the species investigated. These results demonstrate that habitat patch size, mobility, and mating systems can interact in complex ways to structure group size even among closely related species.

  17. In vitro and in vivo evaluation of a hydrogel-based prototype transdermal patch system of alfuzosin hydrochloride.

    Science.gov (United States)

    Nair, Anroop B; Vaka, Siva Ram Kiran; Gupta, Sumit; Repka, Michael A; Murthy, S Narasimha

    2012-01-01

    The first-line therapy for moderate to severe benign prostatic hyperplasia is the oral therapy by alfuzosin hydrochloride. Unfortunately, the oral therapy of alfuzosin is associated with several route-specific systemic side-effects. The current study was aimed to develop a prototype transdermal patch system for alfuzosin using a hydrogel polymer and optimize the drug delivery through the skin for systemic therapy. The prospective of different chemical enhancers (polyethylene glycol (PEG 400), isopropyl myristate, propylene glycol, menthol and L-methionine; 5% w/v) and iontophoresis (0.3 mA/cm(2)) in the alfuzosin delivery across the full thickness rat skin was assessed in vitro. In vivo iontophoretic studies were carried out using selected patch system (PEG 400) for a period of 6 h in Sprague-Dawley rats. Passive permeation studies indicated that the incorporation of chemical agents have moderate effect (~4- to 7-fold) on the alfuzosin skin permeability and reduced the lag time. Combined approach of iontophoresis with chemical enhancers significantly augmented the drug transport (~ 43- to 72-fold). In vivo pharmacokinetic parameters revealed that the iontophoresis (transdermal patch with PEG 400) significantly enhanced the C(max) (~ 3-fold) and AUC(0-α) (~ 4-fold), when compared to control. The current study concludes that the application of iontophoresis (0.3 mA/cm(2)) using the newly developed agaorse-based prototype patch with PEG 400 could be utilized for the successful delivery of alfuzosin by transdermal route.

  18. Pharmacokinetic profile of a new matrix-type transdermal delivery system: diclofenac diethyl ammonium patch.

    Science.gov (United States)

    Devi, K; Paranjothy, K L

    1999-05-01

    A transdermal delivery system containing the anti-inflammatory analgesic diclofenac diethyl ammonium in an ethyl hexyl acrylate and vinyl acetate pressure-sensitive adhesive system was developed for percutaneous absorption. These patches were subjected to in vitro permeation and permeation enhancement studies through rat skin using a specially designed diffusion cell. Further, the work deals with percutaneous absorption studies carried out on both animals and human volunteers. The pharmacokinetic parameters calculated from the blood levels of the drug reveal a profile typical of a sustained-release formulation, with the ability to maintain adequate plasma levels for 24 hr (i.e., up to the next application). (Area under the curve [AUC]: 4.356 +/- 1.3 mcg/ml.hr in animals and 0.442 +/- 0.053 mcg/ml.hr in humans; Tmax was 8 hr in both the cases, whereas Cmax was 0.288 +/- 0.088 mcg/ml in animals and 0.034 +/- .008 mcg/ml in human volunteers.) The amount of the drug bioavailable for targeting the sites of action is lower than via the oral route, but the absorbed dose appears to be adequate for therapeutic use, particularly because of the absence of side effects.

  19. Circular Microstrip Patch Array Antenna for C-Band Altimeter System

    Directory of Open Access Journals (Sweden)

    Asghar Keshtkar

    2008-01-01

    Full Text Available The purpose of this paper is to discuss the practical and experimental results obtained from the design, construction, and test of an array of circular microstrip elements. The aim of this antenna construction was to obtain a gain of 12 dB, an acceptable pattern, and a reasonable value of SWR for altimeter system application. In this paper, the cavity model was applied to analyze the patch and a proper combination of ordinary formulas; HPHFSS software and Microwave Office software were used. The array includes four circular elements with equal sizes and equal spacing and was planed on a substrate. The method of analysis, design, and development of this antenna array is explained completely here. The antenna is simulated and is completely analyzed by commercial HPHFSS software. Microwave Office 2006 software has been used to initially simulate and find the optimum design and results. Comparison between practical results and the results obtained from the simulation shows that we reached our goals by a great degree of validity.

  20. Windows Security patch required

    CERN Multimedia

    2003-01-01

    This concerns Windows PCs (XP, 2000, NT) which are NOT centrally managed at CERN for security patches, e.g. home PCs, experiment PCs, portables, ... A security hole which can give full privileges on Windows systems needs to be URGENTLY patched. Details of the security hole and hotfix are at: http://cern.ch/it-div/news/hotfix-MS03-026.asp http://www.microsoft.com/technet/security/bulletin/MS03-026.asp

  1. Windows Security patch required

    CERN Multimedia

    2003-01-01

    This concerns Windows PCs which are NOT centrally managed at CERN for security patches, e.g. home PCs, experiment PCs, portables, ... A security hole which can give full privileges on Windows systems needs to be URGENTLY patched. Details of the security hole and hotfix are at: http://cern.ch/it-div/news/hotfix-MS03-026.asp http://www.microsoft.com/technet/security/bulletin/MS03-026.asp

  2. Windows Security patch required

    CERN Multimedia

    3004-01-01

    This concerns Windows PCs (XP, 2000, NT) which are NOT centrally managed at CERN for security patches, e.g. home PCs, experiment PCs, portables,... A security hole which can give full privileges on Windows systems needs to be URGENTLY patched. Details of the security hole and hotfix are at: http://cern.ch/it-div/news/hotfix-MS03-026.asp http://www.microsoft.com/technet/security/bulletin/MS03-026.asp

  3. Windows Security patch required

    CERN Multimedia

    2003-01-01

    This concerns Windows PCs (XP, 2000, NT) which are NOT centrally managed at CERN for security patches, e.g. home PCs, experiment PCs, portables,... A security hole which can give full privileges on Windows systems needs to be URGENTLY patched. Details of the security hole and hotfix are at: http://cern.ch/it-div/news/hotfix-MS03-026.asp http://www.microsoft.com/technet/security/bulletin/MS03-026.asp

  4. Development of a patch type embedded cardiac function monitoring system using dual microprocessor for arrhythmia detection in heart disease patient.

    Science.gov (United States)

    Jang, Yongwon; Noh, Hyung Wook; Lee, I B; Jung, Ji-Wook; Song, Yoonseon; Lee, Sooyeul; Kim, Seunghwan

    2012-01-01

    A patch type embedded cardiac function monitoring system was developed to detect arrhythmias such as PVC (Premature Ventricular Contraction), pause, ventricular fibrillation, and tachy/bradycardia. The overall system is composed of a main module including a dual processor and a Bluetooth telecommunication module. The dual microprocessor strategy minimizes power consumption and size, and guarantees the resources of embedded software programs. The developed software was verified with standard DB, and showed good performance.

  5. Mechanical filtering by the boundary layer and fluid-structure interaction in the superficial neuromast of the fish lateral line system

    NARCIS (Netherlands)

    McHenry, Matthew J.; Strother, James A.; van Netten, Sietse M.

    2008-01-01

    A great diversity of aquatic animals detects water flow with ciliated mechanoreceptors on the body's surface. In order to understand how these receptors mechanically filter signals, we developed a theoretical model of the superficial neuromast in the fish lateral line system. The cupula of the neuro

  6. Mechanical filtering by the boundary layer and fluid-structure interaction in the superficial neuromast of the fish lateral line system

    NARCIS (Netherlands)

    McHenry, Matthew J.; Strother, James A.; van Netten, Sietse M.

    A great diversity of aquatic animals detects water flow with ciliated mechanoreceptors on the body's surface. In order to understand how these receptors mechanically filter signals, we developed a theoretical model of the superficial neuromast in the fish lateral line system. The cupula of the

  7. The application of the Escherichia coli giant spheroplast for drug screening with automated planar patch clamp system

    Directory of Open Access Journals (Sweden)

    Kyoko Kikuchi

    2015-09-01

    Full Text Available Kv2.1, the voltage-gated ion channel, is ubiquitously expressed in variety of tissues and dysfunction of this ion channel is responsible for multiple diseases. Electrophysiological properties of ion channels are so far characterized with eukaryotic cells using the manual patch clamp which requires skilful operators and expensive equipments. In this research, we created a simple and sensitive drug screen method using bacterial giant spheroplasts and the automated patch clamp which does not require special skills. We expressed a eukaryotic voltage-gated ion channel Kv2.1 in Escherichia coli using prokaryotic codon, and prepared giant spheroplasts large enough for the patch clamp. Human Kv2.1 currents were successfully recorded from giant spheroplasts with the automated system, and Kv2.1-expressed E. coli spheroplasts could steadily reacted to the dose–response assay with TEA and 4-AP. Collectively, our results indicate for the first time that the bacterial giant spheroplast can be applied for practical pharmaceutical assay using the automated patch clamp.

  8. Dual band multi frequency rectangular patch microstrip antenna with flyswatter shaped slot for wireless systems

    Science.gov (United States)

    Bhardwaj, Dheeraj; Saraswat, Shriti; Gulati, Gitansh; Shekhar, Snehanshu; Joshi, Kanika; Sharma, Komal

    2016-03-01

    In this paper a dual band planar antenna has been proposed for IEEE 802.16 Wi-MAX /IEEE 802.11 WLAN/4.9 GHz public safety applications. The antenna comprises a frequency bandwidth of 560MHz (3.37GHz-3.93GHz) for WLAN and WiMAX and 372MHz (4.82GHz-5.192GHz) for 4.9 GHz public safety applications and Radio astronomy services (4.8-4.94 GHz). The proposed antenna constitutes of a single microstrip patch reactively loaded with three identical steps positioned in a zig-zag manner towards the radiating edges of the patch. The coaxially fed patch antenna characteristics (radiation pattern, antenna gain, antenna directivity, current distribution, S11) have been investigated. The antenna design is primarily focused on achieving a dual band operation.

  9. Dual band multi frequency rectangular patch microstrip antenna with flyswatter shaped slot for wireless systems

    Energy Technology Data Exchange (ETDEWEB)

    Bhardwaj, Dheeraj, E-mail: dbhardwaj.bit@gmail.com [Department of Physics, BIT-Mesra-Jaipur Campus, Jaipur 302017 (India); Saraswat, Shriti, E-mail: saraswat.srishti@gmail.com; Gulati, Gitansh, E-mail: gitanshgulati@gmail.com; Shekhar, Snehanshu, E-mail: snehanshushekhar.bit@gmail.com; Joshi, Kanika, E-mail: kanika.karesh@gmail.com [Department of Electronics & Communication, BIT-Mesra-Jaipur Campus, Jaipur 302017 (India); Sharma, Komal, E-mail: kbhardwaj18@gmail.com [Department of Physics, Swami Keshvanand Institute of Technology, Jaipur 302017 (India)

    2016-03-09

    In this paper a dual band planar antenna has been proposed for IEEE 802.16 Wi-MAX /IEEE 802.11 WLAN/4.9 GHz public safety applications. The antenna comprises a frequency bandwidth of 560MHz (3.37GHz-3.93GHz) for WLAN and WiMAX and 372MHz (4.82GHz-5.192GHz) for 4.9 GHz public safety applications and Radio astronomy services (4.8-4.94 GHz). The proposed antenna constitutes of a single microstrip patch reactively loaded with three identical steps positioned in a zig-zag manner towards the radiating edges of the patch. The coaxially fed patch antenna characteristics (radiation pattern, antenna gain, antenna directivity, current distribution, S{sub 11}) have been investigated. The antenna design is primarily focused on achieving a dual band operation.

  10. Microshear bond strength and interfacial morphology of etch-and-rinse and self-etch adhesive systems to superficial and deep dentin.

    Science.gov (United States)

    Yousry, Mai Mahmoud; ElNaga, Abeer Abo; Hafez, Randa M; El-Badrawy, Wafa

    2011-10-01

    To compare microshear bond strength (uSBS) of two pairs of etch-and-rinse and self-etch adhesives to superficial and deep dentin. Occlusal surfaces of 40 sound extracted noncarious human molars were ground to obtain flat dentin surfaces (20 superficial and 20 deep dentin). Twenty-four teeth were used for uSBS test and 16 for scanning electron microscopic examination. Each dentin group was randomly assigned into four groups, according to the adhesive system tested. An etch-and-rinse and a self-etch adhesive from the same manufacturer were utilized: Scotchbond-MultiPurpose and Adper-Scotchbond SE and XP Bond and Xeno IV. CeramX was used for composite microcylinder construction (0.9 mm in diameter and 0.7 mm in height). Five composite microcylinders were constructed on each dentin surface (n = 15 per group). A Lloyd universal testing machine was used to test uSBS at a crosshead speed of 0.5 mm/min. Fractographic analysis of the failure site was performed using a stereomicroscope and measured by image-analysis software. Data were statistically analyzed using ANOVA and Duncan tests. In superficial dentin, Xeno IV showed significantly the highest uSBS, while in deep dentin, XP Bond showed the highest uSBS. The lowest uSBS values in both dentin depths were recorded for Adper-Scotchbond SE. Etch-and-rinse systems bonded better to deep than to superficial dentin, while self-etching systems showed similar performance at both dentin depths. Bond strength to dentin is both adhesive- and substrate-dependent. Contemporary adhesive systems may produce variable bonding results to superficial and deep dentin due to variations in their composition rather than their bonding approach or application technique.

  11. Systemic BCG-Osis as a Rare Side Effect of Intravesical BCG Treatment for Superficial Bladder Cancer

    Directory of Open Access Journals (Sweden)

    S. Lukacs

    2013-01-01

    Full Text Available Intravesical Bacilli Calmette-Guérin (BCG immunotherapy is a commonly used treatment for superficial bladder cancer. Although the treatment is well tolerated in 95% of cases, life-threatening side effects including BCG sepsis can occur. This report describes the case of an 82-year-old man with a background of lung disease. He developed septic shock and type two respiratory failure after receiving the sixth installation of intravesical BCG (TICE strain immunotherapy for recurrent bladder Transitional Cell Carcinoma in situ. Despite the early initiation of broad spectrum antibiotics (tazocin and gentamicin, he remained pyrexial. There was a rapid deterioration, and on the second day of his admission, he developed type two respiratory failure secondary to Acute Respiratory Distress Syndrome (ARDS prompting transfer to Intensive Care for Bilevel Positive Airway Pressure (BiPAP Ventilation. The blood cultures taken before the induction of antibiotics results were negative. Increasing clinical suspicion of systemic BCG-osis prompted the initiation of antituberculosis therapy (ethambutol, isoniazid rifampicin and steroids. Following six days of BiPAP and anti-tuberculosis therapy in ITU, his condition started to improve. Following a prolonged hospital stay he was discharged on long term ethambutol therapy. BCG-osis is a well-known though rare side effect of intravesical BCG therapy. We would like to highlight the importance of having a low threshold for starting anti-TB treatment.

  12. Topical ketoprofen patch.

    Science.gov (United States)

    Mazières, Bernard

    2005-01-01

    Although oral nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in the treatment of a variety of acute and chronic pain conditions, their use may be associated with serious systemic adverse effects, particularly gastrointestinal disorders. In order to minimise the incidence of systemic events related to such agents, topical NSAIDs have been developed. Topical NSAIDs, applied as gels, creams or sprays, penetrate the skin, subcutaneous fatty tissue and muscle in amounts that are sufficient to exert a therapeutic effect on peripheral and central mechanisms in the absence of high plasma concentrations. Data indicate that topical NSAIDs are effective at relieving pain in a number of acute and chronic pain indications. This review article discusses the pharmacokinetics, efficacy and tolerability of a new formulation of ketoprofen available as a topical patch. The topical patch containing ketoprofen 100mg as the active principle has been developed using a novel delivery system that dispenses therapeutic doses of the drug directly to the site of injury. Pharmacokinetic data indicate that although plasma levels of ketoprofen are higher when the drug is administered as a patch versus a gel, the total systemic bioavailability of ketoprofen 100 mg administered via a patch is no more than 10% of that reported for ketoprofen 100 mg administered orally. Because the patch facilitates ketoprofen delivery over a 24-hour period, the drug remains continually present in the tissue subjacent to the site of application. High tissue but low plasma ketoprofen concentrations mean that while tissue concentrations are high enough to exert a therapeutic effect, plasma concentrations remain low enough to not result in systemic adverse events caused by elevated serum NSAID levels. Phase III clinical trials in patients with non-articular rheumatism and traumatic painful soft tissue injuries showed that the topical ketoprofen patch was significantly more effective than placebo at

  13. Automated Grading System for Evaluation of Corneal Superficial Punctate Keratitis Associated with Dry Eye.

    Science.gov (United States)

    Rodriguez, John D; Lane, Keith; Ousler, George W; Angjeli, Endri; Smith, Lisa; Abelson, Mark

    2015-03-03

    Purpose. To develop an automated method of grading fluorescein staining that accurately reproduces the clinical grading system currently in use. Methods. From the slit lamp photograph of the fluorescein-stained cornea, the region of interest was selected and punctate dot number calculated using software developed with the Opencv computer vision library. Images (N=229) were then divided into six incremental severity categories based on computed scores. The final selection of fifty-four photographs represented the full range of scores: nine images from each of six categories. These were then evaluated by three investigators using a clinical 0-4 corneal staining scale. Pearson correlations were calculated to compare investigator scores, and mean investigator and automated scores. Lin's Concordance Correlations (CCC) and Bland Altman plots were used to assess agreement between methods and between investigators. Results. Pearson's correlation between investigators was 0.914; mean CCC between investigators was 0.882. Bland-Altman analysis indicated that scores assessed by Investigator 3 were significantly higher than those of Investigators 1 and 2 (paired t-test). The predicted grade was calculated to be: Gpred=1.48log(Ndots) - 0.206. The two-point Pearson's correlation coefficient between the methods was 0.927 (p<0.0001). CCC between predicted automated score Gpred and mean investigator score was 0.929, 95% C.I. (0.884, 0.957). Bland-Altman analysis did not indicate bias. The difference in standard deviation between clinical and automated methods was 0.398. Conclusion. An objective, automated analysis of corneal staining provides a quality assurance tool to be used to substantiate clinical grading of key corneal staining endpoints in multi-centered clinical trials of dry eye.

  14. Effect of the Cooling System and 1-MCP on the Incidence of Superficial Scald in ‘Granny Smith’ Apples Efecto del Sistema de Enfriamiento y 1-MCP sobre la Incidencia de Escaldado Superficial en Manzanas ‘Granny Smith’

    Directory of Open Access Journals (Sweden)

    Claudia Moggia

    2009-09-01

    Full Text Available A study was carried out to determine the effects of two cooling systems and the application of 1-methylcyclopropene (1-MCP, SmartFreshTM on the incidence of superficial scald in apples (Malus domestica Borkh. cv. Granny Smith. Fruit were collected from a commercial orchard (Colbún, Maule Region, Chile during 2004-2005 season. A completely randomized design was used in a 2 x 2 factorial arrangement, using cooling systems (normal and step-wise cooling and application of 1-MCP (0 and 625 nL L-1 i.a. as the main factors. Fruit from normal cooling were kept at 0 °C throughout the storage period (180 days. Step-wise cooling consisted of storing the fruit at 10 °C for 10 days; 4 °C for the next 20 days and 0 °C for the remaining 150 days. Every month, maturity indices and the chemicals, global antioxidant content (AO, α-farnesene (AF and conjugated trienes (TC, were measured. Incidence of superficial scald was determined after 180 days of storage, plus 10 days at 20 °C . The application of 1-MCP with both cooling systems was capable of maintaining firmness values around 8,2 kg up to the end of the storage period, as well as decreasing the concentration of AF, TC and AO during storage. Incidence of superficial scald on fruit with 1-MCP was 0%, regardless of the type of cooling. Among treatments without 1-MCP, step-wise-cooling was more effective in preventing superficial scald, resulting in 1.3% incidence compared to 75.6% with the normal cooling system. Nevertheless, from the fourth month onwards firmness was lower than that required for export.Se desarrolló un estudio para determinar el efecto de dos sistemas de enfriamiento y la aplicación de 1-metilciclopropeno (1-MCP, SmartFreshTM sobre la incidencia de escaldado superficial en manzanas (Malus domestica Borkh. cv. Granny Smith, colectadas de un huerto comercial (Colbún, Región del Maule, Chile durante la temporada 2004-2005. El ensayo consistió en un diseño completamente al azar con

  15. System-level design of an RFID sweat electrolyte sensor patch.

    Science.gov (United States)

    Rose, Daniel P; Ratterman, M; Griffin, Daniel K; Hou, Linlin; Kelley-Loughnane, Nancy; Naik, Rajesh K; Hagen, Joshua A; Papautsky, I; Heikenfeld, Jason

    2014-01-01

    Wearable digital health devices are dominantly found in rigid form factors such as bracelets and pucks. An adhesive RFID sensor bandage (patch) is reported, which can be made completely intimate with human skin, a distinct advantage for chronological monitoring of biomarkers in sweat. In this demonstration, a commercial RFID chip is adapted with minimum components to allow potentiometric sensing of mM ionic solutes in sweat, and surface temperature, as read by an Android smart-phone app (in-vitro tests).

  16. Formulation and Evaluation of Galantamine Gel as Drug Reservoir in Transdermal Patch Delivery System

    OpenAIRE

    Woo Fong Yen; Mahiran Basri; Mansor Ahmad; Maznah Ismail

    2015-01-01

    Galantamine hydrobromide is formulated in tablets and capsules prescribed through oral delivery for the treatment of Alzheimer’s disease. However, oral delivery of drugs can cause severe side effects such as nausea, vomiting, and gastrointestinal disturbance. Transdermal delivery of galantamine hydrobromide could avoid these unwanted side effects. In this work, galantamine hydrobromide was formulated in gel drug reservoir which was then fabricated in the transdermal patch. The in vitro drug r...

  17. Microelectromechanical Systems (MEMS) Actuator-Based, Polarization Reconfigurable Patch Antenna Demonstrated

    Science.gov (United States)

    Simons, Rainee N.

    2002-01-01

    A nearly square patch antenna with a contact actuator along a radiating edge for polarization reconfiguration was demonstrated at Ka-band frequencies at the NASA Glenn Research Center. The layout of the antenna is shown in the following sketch. This antenna has the following advantages: 1) It can be dynamically reconfigured to receive and transmit a linearly polarized signal or a circularly polarized signal. This feature allows the substitution of multiple antennas on a satellite by a single antenna, thereby resulting in significant cost savings. 2) In our approach, the polarization is switched between the two states without affecting the frequency of operation; thus, valuable frequency spectrum is conserved. 3) The ability to switch polarization also helps mitigate propagation effects due to adverse weather on the performance of a satellite-to-ground link. Hence, polarization reconfigurability enhances link reliability.

  18. An optogenetics- and imaging-assisted simultaneous multiple patch-clamp recording system for decoding complex neural circuits.

    Science.gov (United States)

    Wang, Guangfu; Wyskiel, Daniel R; Yang, Weiguo; Wang, Yiqing; Milbern, Lana C; Lalanne, Txomin; Jiang, Xiaolong; Shen, Ying; Sun, Qian-Quan; Zhu, J Julius

    2015-03-01

    Deciphering neuronal circuitry is central to understanding brain function and dysfunction, yet it remains a daunting task. To facilitate the dissection of neuronal circuits, a process requiring functional analysis of synaptic connections and morphological identification of interconnected neurons, we present here a method for stable simultaneous octuple patch-clamp recordings. This method allows physiological analysis of synaptic interconnections among 4-8 simultaneously recorded neurons and/or 10-30 sequentially recorded neurons, and it allows anatomical identification of >85% of recorded interneurons and >99% of recorded principal neurons. We describe how to apply the method to rodent tissue slices; however, it can be used on other model organisms. We also describe the latest refinements and optimizations of mechanics, electronics, optics and software programs that are central to the realization of a combined single- and two-photon microscopy-based, optogenetics- and imaging-assisted, stable, simultaneous quadruple-viguple patch-clamp recording system. Setting up the system, from the beginning of instrument assembly and software installation to full operation, can be completed in 3-4 d.

  19. Comparison of diagnostic value using a small, single channel, P-wave centric sternal ECG monitoring patch with a standard 3-lead Holter system over 24 hours.

    Science.gov (United States)

    Smith, Warren M; Riddell, Fiona; Madon, Morag; Gleva, Marye J

    2017-03-01

    To compare simultaneous recordings from an external patch system specifically designed to ensure better P-wave recordings and standard Holter monitor to determine diagnostic efficacy. Holter monitors are a mainstay of clinical practice, but are cumbersome to access and wear and P-wave signal quality is frequently inadequate. This study compared the diagnostic efficacy of the P-wave centric electrocardiogram (ECG) patch (Carnation Ambulatory Monitor) to standard 3-channel (leads V1, II, and V5) Holter monitor (Northeast Monitoring, Maynard, MA). Patients were referred to a hospital Holter clinic for standard clinical indications. Each patient wore both devices simultaneously and served as their own control. Holter and Patch reports were read in a blinded fashion by experienced electrophysiologists unaware of the findings in the other corresponding ECG recording. All patients, technicians, and physicians completed a questionnaire on comfort and ease of use, and potential complications. In all 50 patients, the P-wave centric patch recording system identified rhythms in 23 patients (46%) that altered management, compared to 6 Holter patients (12%), PHolter ECG intervals having correlation coefficients of 0.93, 0.86, and 0.94, respectively. Finally, 48 patients (96%) preferred wearing the patch monitor. A single-channel ambulatory patch ECG monitor, designed specifically to ensure that the P-wave component of the ECG be visible, resulted in a significantly improved rhythm diagnosis and avoided inaccurate diagnoses made by the standard 3-channel Holter monitor. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Diclofenac Transdermal Patch

    Science.gov (United States)

    Transdermal diclofenac comes as a patch to apply to the skin. Diclofenac patches are usually applied two times a day, once every ... your regular schedule. Do not apply an extra diclofenac patch to make up for a missed dose.

  1. Patching for corneal abrasion.

    Science.gov (United States)

    Lim, Chris H L; Turner, Angus; Lim, Blanche X

    2016-07-26

    Published audits have demonstrated that corneal abrasions are a common presenting eye complaint. Eye patches are often recommended for treating corneal abrasions despite the lack of evidence for their use. This systematic review was conducted to determine the effects of the eye patch when used to treat corneal abrasions. The objective of this review was to assess the effects of patching for corneal abrasion on healing and pain relief. We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register) (2016, Issue 4), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to May 2016), EMBASE (January 1980 to May 2016), Latin American and Caribbean Health Sciences Literature Database (LILACS) (January 1982 to May 2016), System for Information on Grey Literature in Europe (OpenGrey) (January 1995 to May 2016), the ISRCTN registry (www.isrctn.com/editAdvancedSearch), ClinicalTrials.gov (www.clinicaltrials.gov) and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 9 May 2016. We also searched the reference lists of included studies, unpublished 'grey' literature and conference proceedings and contacted pharmaceutical companies for details of unpublished trials. We included randomised and quasi-randomised controlled trials that compared patching the eye with no patching to treat simple corneal abrasions. Two authors independently assessed the risk of bias and extracted data. Investigators were contacted for further information regarding the quality of trials. The primary outcome was healing at 24, 48 and 72 hours while secondary outcomes included measures of pain, quality of life and adverse effects. We graded the certainty of the evidence using GRADE. We included 12 trials which

  2. *New* CRITICAL Windows Security patch

    CERN Multimedia

    2003-01-01

    On 10 September 2003, Microsoft issued a new CRITICAL security patch, MS03-039. It must be URGENTLY applied on ALL WINDOWS systems, which are not centrally managed for security patches. This includes Experiment computers, Home computers and Windows Portable and Desktop systems not running NICE. Details of the security hole and patch for MS03-039 (which also includes MS03-026) are at: http://cern.ch/it-div/news/hotfix-MS03-039.asp http://www.microsoft.com/technet/security/bulletin/MS03-039.asp

  3. *New*: CRITICAL Windows Security patch

    CERN Multimedia

    2003-01-01

    On 10 September 2003, Microsoft issued a new CRITICAL security patch, MS03-039. It must be URGENTLY applied on ALL WINDOWS systems, which are not centrally managed for security patches. This includes Experiment computers, Home computers and Windows Portable and Desktop systems not running NICE. Details of the security hole and patch for MS03-039 (which also includes MS03-026) are at: http://cern.ch/it-div/news/hotfix-MS03-039.asp http://www.microsoft.com/technet/security/bulletin/MS03-039.asp

  4. Superficies de segundo orden

    OpenAIRE

    Salazar Salazar, Luis Álvaro

    1987-01-01

    Este trabajo se propone poner al alcance de estudiantes de primeros semestres de carreras de aplicación de la matemática, un algoritmo proporcionado por el álgebra lineal, para tratar con mas generalidad, agilidad y libertad unos objetos de la geometría analítica de no fácil manipulación por otros métodos y que se conocen como superficies de segundo orden o superficies cuádricas. En este orden de ideas, el autor considera importante que con este tratamiento se incluya este tema en una asignat...

  5. Treatment of superficial mycoses: review - part II

    OpenAIRE

    2013-01-01

    Superficial fungal infections of the hair, skin and nails are a major cause of morbidity in the world. Choosing the right treatment is not always simple because of the possibility of drug interactions and side effects. The first part of the article discusses the main treatments for superficial mycoses - keratophytoses, dermatophytosis, candidiasis, with a practical approach to the most commonly-used topical and systemic drugs , referring also to their dosage and duration of use. Promising new...

  6. Treatment of superficial mycoses: review - part II*

    OpenAIRE

    2013-01-01

    Superficial fungal infections of the hair, skin and nails are a major cause of morbidity in the world. Choosing the right treatment is not always simple because of the possibility of drug interactions and side effects. The first part of the article discusses the main treatments for superficial mycoses - keratophytoses, dermatophytosis, candidiasis, with a practical approach to the most commonly-used topical and systemic drugs , referring also to their dosage and duration of use. Promising new...

  7. Bio-patch design and implementation based on a low-power system-on-chip and paper-based inkjet printing technology.

    Science.gov (United States)

    Yang, Geng; Xie, Li; Mantysalo, Matti; Chen, Jian; Tenhunen, Hannu; Zheng, L R

    2012-11-01

    This paper presents the prototype implementation of a Bio-Patch using fully integrated low-power System-on-Chip (SoC) sensor and paper-based inkjet printing technology. The SoC sensor is featured with programmable gain and bandwidth to accommodate a variety of bio-signals. It is fabricated in a 0.18-ìm standard CMOS technology, with a total power consumption of 20 ìW from a 1.2 V supply. Both the electrodes and interconnections are implemented by printing conductive nano-particle inks on a flexible photo paper substrate using inkjet printing technology. A Bio-Patch prototype is developed by integrating the SoC sensor, a soft battery, printed electrodes and interconnections on a photo paper substrate. The Bio-Patch can work alone or operate along with other patches to establish a wired network for synchronous multiple-channel bio-signals recording. The measurement results show that electrocardiogram and electromyogram are successfully measured in in-vivo tests using the implemented Bio-Patch prototype.

  8. On-water remote monitoring robotic system for estimating the patch coverage of Anabaena sp. filaments in shallow water.

    Science.gov (United States)

    Romero-Vivas, E; Von Borstel, F D; Pérez-Estrada, C J; Torres-Ariño, D; Villa-Medina, J F; Gutiérrez, J

    2015-06-01

    An on-water remote monitoring robotic system was developed for indirectly estimating the relative density of marine cyanobacteria blooms at the subtidal sandy-rocky beach in Balandra Cove, Baja California Sur, Mexico. The system is based on an unmanned surface vehicle to gather underwater videos of the seafloor for avoiding physical damage on Anabaena sp. cyanobacteria colonies, which grow in tufts of filaments weakly attached to rocks, seagrass, and macroalgae. An on-axis image stabilization mechanism was developed to support a camcorder and minimize wave perturbation while recording underwater digital images of the seafloor. Color image processing algorithms were applied to estimate the patch coverage area and density, since Anabaena sp. filaments exhibit a characteristic green tone. Results of field tests showed the feasibility of the robotic system to estimate the relative density, distribution, and coverage area of cyanobacteria blooms, preventing the possible impact of direct observation. The robotic system could also be used in surveys of other benthos in the sublittoral zone.

  9. X-Cut LiNbO3 Optical Modulators Using Gap-Embedded Patch-Antennas for Wireless-Over-Fiber Systems

    Directory of Open Access Journals (Sweden)

    Yusuf Nur Wijayanto

    2012-01-01

    Full Text Available We propose an x-cut LiNbO3 optical modulator using gap-embedded patch-antennas for wireless-over-fiber systems. The proposed device is composed of an array of narrow-gap-embedded patch-antennas and an optical waveguide located at the center of the gap without a buffer layer. The modulation efficiency of the proposed x-cut LiNbO3 optical modulators was enhanced by 6 dB compared to the z-cut LiTaO3-based devices.

  10. SafePatch for Windows Version 1.0 User Manual

    Energy Technology Data Exchange (ETDEWEB)

    Lim, D; Meier, T

    2003-05-01

    SafePatch for Windows provides automated analysis of network-based Microsoft Windows{trademark} computer systems to determine the status of security patches. SafePatch determines what patches need to be installed on a system or group of systems. SafePatch collects and packages the necessary patches and the script to install those patches for the selected remote systems. SafePatch for Windows also supports browsing the Microsoft{trademark} patch database and the viewing of the bulletins associated with the patches.

  11. Capability of patch antennas in a portable harmonic radar system to track insects

    Science.gov (United States)

    Monitoring technologies are needed to track insects and gain a better understanding of their behavior, population, migration and movement. A portable microwave harmonic-radar tracking system that utilizes antenna miniaturization techniques was investigated to achieve this goal. The system mainly con...

  12. Common Superficial Bursitis.

    Science.gov (United States)

    Khodaee, Morteza

    2017-02-15

    Superficial bursitis most often occurs in the olecranon and prepatellar bursae. Less common locations are the superficial infrapatellar and subcutaneous (superficial) calcaneal bursae. Chronic microtrauma (e.g., kneeling on the prepatellar bursa) is the most common cause of superficial bursitis. Other causes include acute trauma/hemorrhage, inflammatory disorders such as gout or rheumatoid arthritis, and infection (septic bursitis). Diagnosis is usually based on clinical presentation, with a particular focus on signs of septic bursitis. Ultrasonography can help distinguish bursitis from cellulitis. Blood testing (white blood cell count, inflammatory markers) and magnetic resonance imaging can help distinguish infectious from noninfectious causes. If infection is suspected, bursal aspiration should be performed and fluid examined using Gram stain, crystal analysis, glucose measurement, blood cell count, and culture. Management depends on the type of bursitis. Acute traumatic/hemorrhagic bursitis is treated conservatively with ice, elevation, rest, and analgesics; aspiration may shorten the duration of symptoms. Chronic microtraumatic bursitis should be treated conservatively, and the underlying cause addressed. Bursal aspiration of microtraumatic bursitis is generally not recommended because of the risk of iatrogenic septic bursitis. Although intrabursal corticosteroid injections are sometimes used to treat microtraumatic bursitis, high-quality evidence demonstrating any benefit is unavailable. Chronic inflammatory bursitis (e.g., gout, rheumatoid arthritis) is treated by addressing the underlying condition, and intrabursal corticosteroid injections are often used. For septic bursitis, antibiotics effective against Staphylococcus aureus are generally the initial treatment, with surgery reserved for bursitis not responsive to antibiotics or for recurrent cases. Outpatient antibiotics may be considered in those who are not acutely ill; patients who are acutely ill

  13. SUPERFICIAL CERVICAL PLEXUS BLOCK

    Directory of Open Access Journals (Sweden)

    Komang Mega Puspadisari

    2014-01-01

    Full Text Available Superficial cervical plexus block is one of the regional anesthesia in  neck were limited to thesuperficial fascia. Anesthesia is used to relieve pain caused either during or after the surgery iscompleted. This technique can be done by landmark or with ultrasound guiding. The midpointof posterior border of the Sternocleidomastoid was identified and the prosedure done on thatplace or on the level of cartilage cricoid.

  14. Metal Patch Antenna

    Science.gov (United States)

    Chamberlain, Neil F. (Inventor); Hodges, Richard E. (Inventor); Zawadzki, Mark S. (Inventor)

    2012-01-01

    Disclosed herein is a patch antenna comprises a planar conductive patch attached to a ground plane by a support member, and a probe connector in electrical communication with the conductive patch arranged to conduct electromagnetic energy to or from the conductive patch, wherein the conductive patch is disposed essentially parallel to the ground plane and is separated from the ground plane by a spacing distance; wherein the support member comprises a plurality of sides disposed about a central axis oriented perpendicular to the conductive patch and the ground plane; wherein the conductive patch is solely supported above the ground plane by the support member; and wherein the support member provides electrical communication between the planer conductive patch and the ground plane.

  15. Birth Control Patch

    Science.gov (United States)

    ... Surgery? A Week of Healthy Breakfasts Shyness Birth Control Patch KidsHealth > For Teens > Birth Control Patch Print A A A What's in this ... Does It Cost? What Is It? The birth control patch is a thin, beige, 1¾-inch (4½- ...

  16. Birth Control Patch

    Science.gov (United States)

    ... Loss Surgery? A Week of Healthy Breakfasts Shyness Birth Control Patch KidsHealth > For Teens > Birth Control Patch A A A What's in this article? ... Much Does It Cost? What Is It? The birth control patch is a thin, beige, 1¾-inch (4½- ...

  17. A new Self-Adaptive disPatching System for local clusters

    Science.gov (United States)

    Kan, Bowen; Shi, Jingyan; Lei, Xiaofeng

    2015-12-01

    The scheduler is one of the most important components of a high performance cluster. This paper introduces a self-adaptive dispatching system (SAPS) based on Torque[1] and Maui[2]. It promotes cluster resource utilization and improves the overall speed of tasks. It provides some extra functions for administrators and users. First of all, in order to allow the scheduling of GPUs, a GPU scheduling module based on Torque and Maui has been developed. Second, SAPS analyses the relationship between the number of queueing jobs and the idle job slots, and then tunes the priority of users’ jobs dynamically. This means more jobs run and fewer job slots are idle. Third, integrating with the monitoring function, SAPS excludes nodes in error states as detected by the monitor, and returns them to the cluster after the nodes have recovered. In addition, SAPS provides a series of function modules including a batch monitoring management module, a comprehensive scheduling accounting module and a real-time alarm module. The aim of SAPS is to enhance the reliability and stability of Torque and Maui. Currently, SAPS has been running stably on a local cluster at IHEP (Institute of High Energy Physics, Chinese Academy of Sciences), with more than 12,000 cpu cores and 50,000 jobs running each day. Monitoring has shown that resource utilization has been improved by more than 26%, and the management work for both administrator and users has been reduced greatly.

  18. Superficies de placer

    OpenAIRE

    Delli Gatti, Romina

    2012-01-01

    La presente tesis cuenta con 28 pinturas en distintos formatos y tama- ños a través de los cuales la artista investiga diferentes objetos de su entorno cotidiano que le resultan agradables y pueden llegar a transformar anímicamente. De esta manera se van construyendo superficies ideales, relacionadas principalmente con lo cotidiano y lo intimo, lo orgánico, lo industrial, el diseño textil y lo abstracto. Es un intento por generar o prolongar una sensación visual de agrado y placer a tra...

  19. Improved patch antenna performance by using a metamaterial cover

    Institute of Scientific and Technical Information of China (English)

    ZHU Fang-ming; HU Jun

    2007-01-01

    A new patch antenna system with a metamaterial cover is presented in this paper. The impedance, radiation pattern, and directivity of such an antenna are studied. A performance comparison between the conventional patch antenna and the new metamaterial patch antenna is given. The results show that the directivity of the metamaterial patch antenna is significantly improved. The effect of the metamaterial cover's layer numbers on the radiation pattern of the patch antenna is also studied.

  20. Demonstration of an instrumented patch

    Science.gov (United States)

    Martinez, M.; Renaud, G.; Backman, D.; Genest, M.; Delannoy, M.

    2007-04-01

    The primary objective of this study was to demonstrate the effectiveness of various strain measurement techniques at detecting the disbonding of a composite repair patch and then using this information to validate a new capacitance based disbond detection technique. The instrumented repair patch was parametrically designed with the help of Finite Element Analysis (FEA) software to have a stress concentration at its tip. This stress concentration was designed to produce a disbond during fatigue testing, without the need for the introduction of any foreign material to create an artificial disbond condition. The aluminum substrate was grit blasted and the instrumented patch was bonded using FM ®73 adhesive, and was cured following the recommendations of the manufacturer. The geometric characteristics of the patch followed standard repair guidelines for such variables as material selection, taper angles and loading conditions, with the exception of the area designed for premature disbond. All test specimens were inspected using non-destructive testing technique (ultrasound pulse echo) to guarantee that no disbonding had occurred during curing of the specimen. The specimens were placed under fatigue loading to induce a disbond condition between the aluminum substrate and the patch. The specimens were cyclically loaded and strain gauges bonded to strategic locations on the aluminum and composite patch surface to be able to measure changes in surface strains as the disbond progressed. A Digital Image Correlation (DIC) system was also used to measure full field strains over the gauge length of the coupon. The DIC results were compared with the strain gauge data and were used to provide a qualitative measure of the load transfer in the bonded specimen, which clearly demonstrated the change in surface strain that occurred as the composite patch disbonded from the aluminum substrate. Thermoelastic Stress Analysis (TSA) was also used to measure surface strains on the

  1. Accuracy of a New Patch Pump Based on a Microelectromechanical System (MEMS) Compared to Other Commercially Available Insulin Pumps

    Science.gov (United States)

    Borot, Sophie; Franc, Sylvia; Cristante, Justine; Penfornis, Alfred; Benhamou, Pierre-Yves; Guerci, Bruno; Hanaire, Hélène; Renard, Eric; Reznik, Yves; Simon, Chantal

    2014-01-01

    The JewelPUMP™ (JP) is a new patch pump based on a microelectromechanical system that operates without any plunger. The study aimed to evaluate the infusion accuracy of the JP in vitro and in vivo. For the in vitro studies, commercially available pumps meeting the ISO standard were compared to the JP: the MiniMed® Paradigm® 712 (MP), Accu-Chek® Combo (AC), OmniPod® (OP), Animas® Vibe™ (AN). Pump accuracy was measured over 24 hours using a continuous microweighing method, at 0.1 and 1 IU/h basal rates. The occlusion alarm threshold was measured after a catheter occlusion. The JP, filled with physiological serum, was then tested in 13 patients with type 1 diabetes simultaneously with their own pump for 2 days. The weight difference was used to calculate the infused insulin volume. The JP showed reduced absolute median error rate in vitro over a 15-minute observation window compared to other pumps (1 IU/h): ±1.02% (JP) vs ±1.60% (AN), ±1.66% (AC), ±2.22% (MP), and ±4.63% (OP), P pumps: 21 (19; 25) minutes vs 90 (85; 95), 58 (42; 74), and 143 (132; 218) minutes (AN, AC, MP), P pumps (–2.2 ± 5.6% vs –0.37 ± 4.0%, P = .25). The JP was found to be easier to wear than conventional pumps. The JP is more precise over a short time period, more sensitive to catheter occlusion, well accepted by patients, and consequently, of potential interest for a closed-loop insulin delivery system. PMID:25079676

  2. Robustness of metacommunities with omnivory to habitat destruction: disentangling patch fragmentation from patch loss.

    Science.gov (United States)

    Liao, Jinbao; Bearup, Daniel; Wang, Yeqiao; Nijs, Ivan; Bonte, Dries; Li, Yuanheng; Brose, Ulrich; Wang, Shaopeng; Blasius, Bernd

    2017-06-01

    Habitat destruction, characterized by patch loss and fragmentation, is a major driving force of species extinction, and understanding its mechanisms has become a central issue in biodiversity conservation. Numerous studies have explored the effect of patch loss on food web dynamics, but ignored the critical role of patch fragmentation. Here we develop an extended patch-dynamic model for a tri-trophic omnivory system with trophic-dependent dispersal in fragmented landscapes. We found that species display different vulnerabilities to both patch loss and fragmentation, depending on their dispersal range and trophic position. The resulting trophic structure varies depending on the degree of habitat loss and fragmentation, due to a tradeoff between bottom-up control on omnivores (dominated by patch loss) and dispersal limitation on intermediate consumers (dominated by patch fragmentation). Overall, we find that omnivory increases system robustness to habitat destruction relative to a simple food chain. © 2017 by the Ecological Society of America.

  3. *NEW* CRITICAL Windows Security patches

    CERN Multimedia

    2003-01-01

    On 3 October and 10 September 2003, Microsoft issued new CRITICAL security patches MS03-040 and MS03-039. They must be URGENTLY applied on ALL WINDOWS systems, which are not centrally managed for security patches. This includes Experiment computers, Home computers and Windows Portable and Desktop systems not running NICE. Details of the security holes and patches are at: MS03-039: http://cern.ch/it-div/news/hotfix-MS03-039.asp http://www.microsoft.com/technet/security/bulletin/MS03-039.asp MS03-040: http://cern.ch/it-div/news/hotfix-MS03-040.asp http://www.microsoft.com/technet/security/bulletin/MS03-040.asp

  4. Systems biology analysis of Brucella infected Peyer's patch reveals rapid invasion with modest transient perturbations of the host transcriptome.

    Directory of Open Access Journals (Sweden)

    Carlos A Rossetti

    Full Text Available Brucella melitensis causes the most severe and acute symptoms of all Brucella species in human beings and infects hosts primarily through the oral route. The epithelium covering domed villi of jejunal-ileal Peyer's patches is an important site of entry for several pathogens, including Brucella. Here, we use the calf ligated ileal loop model to study temporal in vivo Brucella-infected host molecular and morphological responses. Our results document Brucella bacteremia occurring within 30 min after intraluminal inoculation of the ileum without histopathologic traces of lesions. Based on a system biology Dynamic Bayesian Network modeling approach (DBN of microarray data, a very early transient perturbation of the host enteric transcriptome was associated with the initial host response to Brucella contact that is rapidly averted allowing invasion and dissemination. A detailed analysis revealed active expression of Syndecan 2, Integrin alpha L and Integrin beta 2 genes, which may favor initial Brucella adhesion. Also, two intestinal barrier-related pathways (Tight Junction and Trefoil Factors Initiated Mucosal Healing were significantly repressed in the early stage of infection, suggesting subversion of mucosal epithelial barrier function to facilitate Brucella transepithelial migration. Simultaneously, the strong activation of the innate immune response pathways would suggest that the host mounts an appropriate protective immune response; however, the expression of the two key genes that encode innate immunity anti-Brucella cytokines such as TNF-α and IL12p40 were not significantly changed throughout the study. Furthermore, the defective expression of Toll-Like Receptor Signaling pathways may partially explain the lack of proinflammatory cytokine production and consequently the absence of morphologically detectable inflammation at the site of infection. Cumulatively, our results indicate that the in vivo pathogenesis of the early infectious process

  5. Patch test results with fragrance markers of the baseline series - analysis of the European Surveillance System on Contact Allergies (ESSCA) network 2009-2012

    DEFF Research Database (Denmark)

    Frosch, Peter J; Duus Johansen, Jeanne; Schuttelaar, Marie-Louise A;

    2015-01-01

    of patients consecutively patch tested between 2009 and 2012 in 12 European countries with fragrance allergens contained in the baseline series were collected by the European Surveillance System on Contact Allergies network and descriptively analysed. Four departments used the TRUE Test(®) system. RESULTS......BACKGROUND: Contact allergy to fragrances is common, and impairs quality of life, particularly in young women. OBJECTIVE: To provide current results on the prevalences of sensitization to fragrance allergens used as markers in the baseline series of most European countries. METHODS: Data......: Contact allergy to fragrances is common throughout Europe, with regional variation probably being explained by patch test technique, and differences in exposure and referral patterns. The current basic markers of fragrance sensitivity in the baseline series should be supplemented with additional fragrance...

  6. Superficial Temporal Artery Pseudoaneurysm: A Case Report

    Science.gov (United States)

    Younus, Syed Muneeb; Imran, Muhammad; Qazi, Rabia

    2015-01-01

    Pseudoaneurysms of the superficial temporal artery are an uncommon vascular lesion of the external carotid system and most often the result of blunt head trauma. The frequency of pseudoaneurysms of the superficial temporal artery developing after craniotomy is exceedingly low and only a few cases have been reported. We present a case of pseudoaneurysm of this type in a 45-year-old male who underwent craniotomy for excision of meningioma. One month postoperatively, the craniotomy flap exhibited an enormous diffuse pulsate swelling. The suspected diagnosis of pseudoaneurysm arising from superficial temporal artery was confirmed on angiography. Surgical excision was done and no recurrences of the tumor or aneurysm were noted on subsequent follow up. PMID:26501064

  7. Treatment of superficial mycoses: review - part II*

    Science.gov (United States)

    Dias, Maria Fernanda Reis Gavazzoni; Bernardes-Filho, Fred; Quaresma-Santos, Maria Victória Pinto; Amorim, Adriana Gutstein da Fonseca; Schechtman, Regina Casz; Azulay, David Rubem

    2013-01-01

    Superficial fungal infections of the hair, skin and nails are a major cause of morbidity in the world. Choosing the right treatment is not always simple because of the possibility of drug interactions and side effects. The first part of the article discusses the main treatments for superficial mycoses - keratophytoses, dermatophytosis, candidiasis, with a practical approach to the most commonly-used topical and systemic drugs , referring also to their dosage and duration of use. Promising new, antifungal therapeutic alternatives are also highlighted, as well as available options on the Brazilian and world markets. PMID:24474103

  8. Treatment of superficial mycoses: review. Part II.

    Science.gov (United States)

    Dias, Maria Fernanda Reis Gavazzoni; Bernardes-Filho, Fred; Quaresma-Santos, Maria Victória Pinto; Amorim, Adriana Gutstein da Fonseca; Schechtman, Regina Casz; Azulay, David Rubem

    2013-01-01

    Superficial fungal infections of the hair, skin and nails are a major cause of morbidity in the world. Choosing the right treatment is not always simple because of the possibility of drug interactions and side effects. The first part of the article discusses the main treatments for superficial mycoses - keratophytoses, dermatophytosis, candidiasis, with a practical approach to the most commonly-used topical and systemic drugs , referring also to their dosage and duration of use. Promising new, antifungal therapeutic alternatives are also highlighted, as well as available options on the Brazilian and world markets.

  9. Danish pain specialists' rationales behind the choice of fentanyl transdermal patches and oral transmucosal systems-A Delphi study

    DEFF Research Database (Denmark)

    Jacobsen, Ramune; Møldrup, Claus; Christrup, Lona

    2009-01-01

    survey. Response rates were 45% in the brainstorming and 88% in the rating phases, respectively. Statistical analysis with SPSS for Windows 15.00 included descriptive statistics and factor analysis. Results. The most important rationale to choose fentanyl patches was that patients' clinical condition did...

  10. Characteristics of patients patch tested in the European Surveillance System on Contact Allergies (ESSCA) network, 2009-2012

    NARCIS (Netherlands)

    Uter, Wolfgang; Gefeller, Olaf; Gimenez-Arnau, Ana; Frosch, Peter; Johansen, Jeanne Duus; Schuttelaar, Marie-Louise; Rustemeyer, Thomas; Filon, Francesca Larese; Dugonik, Aleksandra; Bircher, Andreas; Wilkinson, Mark

    2015-01-01

    BackgroundPatch test results often vary between departments, and also between countries. Such variation may be partly attributable to systematic effects introduced by patient characteristics, differing exposures, patient selection, or methodological differences. ObjectiveTo examine the amount of var

  11. Transdermal patches: history, development and pharmacology.

    Science.gov (United States)

    Pastore, Michael N; Kalia, Yogeshvar N; Horstmann, Michael; Roberts, Michael S

    2015-05-01

    Transdermal patches are now widely used as cosmetic, topical and transdermal delivery systems. These patches represent a key outcome from the growth in skin science, technology and expertise developed through trial and error, clinical observation and evidence-based studies that date back to the first existing human records. This review begins with the earliest topical therapies and traces topical delivery to the present-day transdermal patches, describing along the way the initial trials, devices and drug delivery systems that underpin current transdermal patches and their actives. This is followed by consideration of the evolution in the various patch designs and their limitations as well as requirements for actives to be used for transdermal delivery. The properties of and issues associated with the use of currently marketed products, such as variability, safety and regulatory aspects, are then described. The review concludes by examining future prospects for transdermal patches and drug delivery systems, such as the combination of active delivery systems with patches, minimally invasive microneedle patches and cutaneous solutions, including metered-dose systems.

  12. Fabrication and Characterization of Multi-Walled Carbon Nanotube (MWCNT) and Ni-Coated Multi-Walled Carbon Nanotube (Ni-MWCNT) Repair Patches for Carbon Fiber Reinforced Composite Systems

    Science.gov (United States)

    Johnson, Brienne; Caraccio, Anne; Tate, LaNetra; Jackson, Dionne

    2011-01-01

    Multi-walled carbon nanotube (MWCNT)/epoxy and nickel-coated multi-walled carbon nanotube (Ni-MWCNT)/epoxy systems were fabricated into carbon fiber composite repair patches via vacuum resin infusion. Two 4 ply patches were manufactured with fiber orientations of [90/ 90/ 4590] and [0/90/ +45/ -45]. Prior to resin infusion, the MWCNT/Epoxy system and NiMWCNT/ epoxy systems were optimized for dispersion quality. Scanning electron microscopy (SEM) and optical microscopy (OM) were used to determine the presence ofcarbon nanotubes and assess dispersion quality. Decomposition temperatures were determined via thermogravametric analysis (TGA). SEM and TGA were also used to evaluate the composite repair patches.

  13. Common bean cultivars response to lime surface application under no tillage systemResposta de cultivares de feijoeiro comum à calagem superficial em semeadura direta

    Directory of Open Access Journals (Sweden)

    Carlos Alexandre Costa Crusciol

    2012-08-01

    Full Text Available Soil acidity in no tillage system, if not in high situations, can be neutralized by lime surface application, improving mineral nutrition and crop yield. Aiming to evaluate the agronomic performance of common bean cultivars, to surface lime application, in no tillage system, an experiment was conducted in Oxisol, Botucatu Municipal District, São Paulo State, Brazil. The experimental design was a complete randomized block in split plot with four replications, where the plots were formed by common bean cultivars (Carioca, IAC Carioca Eté, Pérola, IAPAR 81 e Campeão 2 and subplots consisted of surface application of dolomitic limestone (zero, 1.8 t ha-1, 3.6 t ha-1 and 5.4 t ha-1. The surface lime application on the soil occurred in October 2002 and subsequently the sequence millet (spring – beans (summer – oat (autumn-winter were planted under rainfed conditions. Bean cultivars sowing were done on December 17, 2003. It can be concluded that there is influence of cultivars and limestone surface application under no tillage, where IAPAR 81 showed better grain yield with the increase of lime rates, obtaining values of 2,025 kg ha-1 without the lime application to 2,655 kg ha-1 with 5.4 t ha-1 lime rate, obtaining 31% yield increase. A acidez do solo no sistema de semeadura direta, caso não se encontre em situações elevadas, pode ser resolvida com aplicação superficial de calcário, melhorando a nutrição mineral e a produtividade das culturas. Com o objetivo de avaliar o desempenho agronômico de cultivares de feijoeiro, em razão da aplicação superficial de calcário, em semeadura direta, foi realizado um experimento num Latossolo Vermelho distrófico, em Botucatu (SP. O delineamento experimental foi o de blocos casualizados, em esquema de parcelas subdivididas com quatro repetições, onde as parcelas foram formadas por cultivares de feijão comum (Carioca, IAC Carioca Eté, Pérola, IAPAR 81 e Campeão 2 e as subparcelas constitu

  14. Automated planar patch-clamp.

    Science.gov (United States)

    Milligan, Carol J; Möller, Clemens

    2013-01-01

    Ion channels are integral membrane proteins that regulate the flow of ions across the plasma membrane and the membranes of intracellular organelles of both excitable and non-excitable cells. Ion channels are vital to a wide variety of biological processes and are prominent components of the nervous system and cardiovascular system, as well as controlling many metabolic functions. Furthermore, ion channels are known to be involved in many disease states and as such have become popular therapeutic targets. For many years now manual patch-clamping has been regarded as one of the best approaches for assaying ion channel function, through direct measurement of ion flow across these membrane proteins. Over the last decade there have been many remarkable breakthroughs in the development of technologies enabling the study of ion channels. One of these breakthroughs is the development of automated planar patch-clamp technology. Automated platforms have demonstrated the ability to generate high-quality data with high throughput capabilities, at great efficiency and reliability. Additional features such as simultaneous intracellular and extracellular perfusion of the cell membrane, current clamp operation, fast compound application, an increasing rate of parallelization, and more recently temperature control have been introduced. Furthermore, in addition to the well-established studies of over-expressed ion channel proteins in cell lines, new generations of planar patch-clamp systems have enabled successful studies of native and primary mammalian cells. This technology is becoming increasingly popular and extensively used both within areas of drug discovery as well as academic research. Many platforms have been developed including NPC-16 Patchliner(®) and SyncroPatch(®) 96 (Nanion Technologies GmbH, Munich), CytoPatch™ (Cytocentrics AG, Rostock), PatchXpress(®) 7000A, IonWorks(®) Quattro and IonWorks Barracuda™, (Molecular Devices, LLC); Dynaflow(®) HT (Cellectricon

  15. Use of the Stingray Re-Entry System in Two Complex Cases of Occluded Superficial Femoral Arteries

    OpenAIRE

    Galbraith, Erin M.; Marc Del Rosario; Khusrow Niazi

    2011-01-01

    Totally occluded infrainguinal arterial disease presents formidable challenges to endovascular revascularization. A variety of devices have been made available to make the crossing of these lesions more amenable to endovascular techniques. We discuss the novel use of a device that has been developed for crossing occluded coronary arteries, the Stingray Re-Entry System.

  16. Use of the Stingray Re-Entry System in Two Complex Cases of Occluded Superficial Femoral Arteries

    Directory of Open Access Journals (Sweden)

    Erin M. Galbraith

    2011-01-01

    Full Text Available Totally occluded infrainguinal arterial disease presents formidable challenges to endovascular revascularization. A variety of devices have been made available to make the crossing of these lesions more amenable to endovascular techniques. We discuss the novel use of a device that has been developed for crossing occluded coronary arteries, the Stingray Re-Entry System.

  17. Granisetron Transdermal Patch

    Science.gov (United States)

    ... are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using transdermal granisetron, call your doctor.plan to protect the granisetron patch and the skin around it from real and artificial sunlight (tanning beds, sunlamps). Keep the patch covered ...

  18. Capacitance of circular patch resonator

    Energy Technology Data Exchange (ETDEWEB)

    Miano, G.; Verolino, L. [Dip. di Ingegneria Elettrica, Ist. Nazionale di Fisica Nucleare, Naples (Italy); Panariello, G. [Dip. di Ingegneria Elettronica, Naples (Italy); Vaccaro, V.G. [Ist. Nazionale di Fisica Nucleare, Naples (Italy). Dipt. di Scienze Fisiche

    1995-11-01

    In this paper the capacitance of the circular microstrip patch resonator is computed. It is shown that the electrostatic problem can be formulated as a system of dual integral equations, and the most interesting techniques of solutions of these systems are reviewed. Some useful approximated formulas for the capacitance are derived and plots of the capacitance are finally given in a wide range of dielectric constants.

  19. A Comparison Between Two Methods of Face-Lift Surgery in Nine Cadavers: SMAS (Superficial Musculo-Aponeurotic System) Versus MACS (Minimal Access Cranial Suspension).

    Science.gov (United States)

    Mohammadi, Shabahang; Ahmadi, Aslan; Salem, Mohammad Mahdi; Safdarian, Mahdi; Ilkhani, Shahriar

    2015-10-01

    This study aimed to compare the average amounts of facial skin and muscle lifting in two different face-lift methods, superficial musculo-aponeurotic system (SMAS) plication and minimal access cranial suspension (MACS), to evaluate the effectiveness of each method in facial excursion. Thirty-six face-lift surgeries were performed on nine cadavers between October and December 2010. Both SMAS and MACS surgeries were done on each side of the cadaver faces. The average amounts of skin and muscle lifting up and out in three defined anatomical landmarks were compared between the two methods, SMAS plication and MACS lift procedure. Nine fresh cadavers with the mean age of 53 ± 6.7 years entered the study. Seven (77.8 %) were males and two (22.2 %) were females. The average amounts of lifting of the anatomical landmarks up and out were significantly greater in the SMAS plication method compared to the MACS lift procedure (P values <0.05), whereas facial symmetry was not significantly different between the two methods. The overall amounts of facial skin and muscle lifting by the SMAS plication method were greater than the MACS lift procedure. However, it does not justify ignoring the benefits of the MACS lift procedure in terms of less invasiveness and quicker recovery. This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

  20. Studying mechanosensitive ion channels with an automated patch clamp

    NARCIS (Netherlands)

    Barthmes, Maria; Jose, Mac Donald F; Birkner, Jan Peter; Brüggemann, Andrea; Wahl-Schott, Christian; Kocer, Armagan

    2014-01-01

    Patch clamp electrophysiology is the main technique to study mechanosensitive ion channels (MSCs), however, conventional patch clamping is laborious and success and output depends on the skills of the operator. Even though automated patch systems solve these problems for other ion channels, they cou

  1. Cochlear implantation in superficial siderosis.

    Science.gov (United States)

    Kim, Chong-Sun; Song, Jae-Jun; Park, Min-Hyun; Kim, Young Ho; Koo, Ja-Won

    2006-08-01

    Superficial siderosis (SS) of the central nervous system has been thought to be a rare condition that generates progressive hearing loss, ataxia, pyramidal signs, and dementia. The main cause of hearing loss by SS is thought to be neuronal. Because there is no histopathologic report of the human temporal bone in SS, there is a debate about the possibility of cochlear involvement. We present a 25-year-old man who was investigated for bilateral progressive sensorineural hearing loss and vestibular failure after head trauma. On brain MRI, SS of the central nervous system was detected. Distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) showed no response on both sides. However, integrity of the eighth nerve was proved by the electrical ABR test on the right side and the patient benefited significantly from cochlear implantation. The sensorineural hearing loss in SS seems to be related to cochlear damage as well as neuronal damage. So, cochlear implantation would be a hearing rehabilitation modality for the sensorineural hearing loss caused by SS.

  2. Oxybutynin Transdermal Patch

    Science.gov (United States)

    ... clothing, and where it will be protected from sunlight by clothing. After you apply a patch to ... stomach extreme tiredness drowsiness headache blurred vision flushing back pain Some side effects can be serious. The following ...

  3. Shallow ATRIS Seafloor Images - West Turtle Shoal Patch Reef, Rawa PatchReef, Dustan Rocks Patch Reef, and Thor Patch Reef, Florida, 2011

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Underwater digital images, single-beam bathymetry, and global-positioning system (GPS) data were collected September 29-30, 2011 around Dustan Rocks Patch Reef, Thor...

  4. Comparison of abuse, suspected suicidal intent, and fatalities related to the 7-day buprenorphine transdermal patch versus other opioid analgesics in the National Poison Data System.

    Science.gov (United States)

    Coplan, Paul M; Sessler, Nelson E; Harikrishnan, Venkatesh; Singh, Richa; Perkel, Charles

    2017-01-01

    Prescription opioid related abuse, suicide and death are significant public health problems. This study compares rates of poison center calls categorized as intentional abuse, suspected suicidal intent or fatality for the 7-day buprenorphine transdermal system/patch (BTDS) with other extended-release and long-acting (ER/LA) opioids indicated for chronic pain. Retrospective 24-month cohort study using National Poison Data System data from July 2012 through June 2014. BTDS was introduced in the United States in January 2011. Numbers and rates of calls of intentional abuse, suspected suicidal intent and fatalities were evaluated for BTDS, ER morphine, ER oxycodone, fentanyl patch, ER oxymorphone and methadone tablets/capsules, using prescription adjustment to account for community availability. Rate ratios (RR) and 95% confidence intervals (CI) were calculated. Absolute numbers and prescription-adjusted rates of intentional abuse and suspected suicidal intent with BTDS were significantly lower (p opioid analgesics examined. No fatalities associated with BTDS exposure were reported. This post-marketing evaluation of BTDS indicates infrequent poison center calls for intentional abuse and suspected suicidal intent events, suggesting lower rates of these risks with BTDS compared to other ER/LA opioids.

  5. A new hypogean Trechus Clairville (Coleoptera, Carabidae, Trechini) discovered in a non-calcareous Superficial Subterranean Habitat of the Iberian System (Central Spain).

    Science.gov (United States)

    Ortuño, Vicente M; Cuesta, Eva; Gilgado, José D; Ledesma, Enrique

    2014-01-01

    A new hypogean species of Trechus Clairville, Trechus arrecheai sp. nov., is described from the Iberian Peninsula. It was captured by subterranean pitfall traps in a non-calcareous Superficial Subterranean Habitat from the Moncayo Massif (Zaragoza, Spain). Data on the accompanying fauna are provided and the biogeographical implications of this discovery are discussed. A synthesis of the data about the known distribution of the Trechus angusticollis species group is provided.

  6. Esophageal Inlet Patch

    Directory of Open Access Journals (Sweden)

    C. Behrens

    2011-01-01

    Full Text Available An inlet patch is a congenital anomaly consisting of ectopic gastric mucosa at or just distal to the upper esophageal sphincter. Most inlet patches are largely asymptomatic, but in problematic cases complications related to acid secretion such as esophagitis, ulcer, web and stricture may occur. The diagnosis of inlet patch is strongly suggested on barium swallow where the most common pattern consists of two small indentations on the wall of the esophagus. The diagnosis of inlet patch is confirmed via endoscopy with biopsy. At endoscopy, the lesion appears salmon-coloured and velvety and is easily distinguished from the normal grey-white squamous epithelium of the esophagus. The prominent margins correlate with the radiological findings of indentations and rim-like shadows on barium swallow. Histopathology provides the definitive diagnosis by demonstrating gastric mucosa adjacent to normal esophageal mucosa. No treatment is required for asymptomatic inlet patches. Symptomatic cases are treated with proton pump inhibitors to relieve symptoms related to acid secretion. Strictures and webs are treated with serial dilatation and should be biopsied to rule out malignancy.

  7. Prolene hernia system, ultrapro hernia system and 3D patch devices in the treatment of inguinal, femoral, umbilical and small incisional hernias in outpatient surgery.

    Science.gov (United States)

    Dabić, D; Cerović, S; Azanjaç, B; Marić, B; Kostić, I

    2010-01-01

    The employment of a diversity of prosthetic materials and several types of mesh different in construction is opening a new chapter in hernia surgery and tension-free techniques are becoming a "golden standard" for repairing abdominal wall defects, whereas the conventional methods, i.e., the tension techniques are performed on young patients having small direct, indirect, or femoral hernias. The aim of this retrospective study is to present the results of using Prolene Hernia System (PHS), Ultrapro Hernia System (UHS) and 3D Patch (3DP) devices in the treatment of inguinal, femoral, umbilical and small incisional hernias in outpatient surgery. From January 2006 to January 2009, 70 patients were operated on for abdominal wall hernias (54 inguinal, 4 femoral, 8 umbilical and 4 small incisional hernias) using PHS, UHS and 3DP devices. All the patients underwent surgery under local infiltrative anaesthesia. All the surgical operations were performed by a single surgeon, 19 of them in the General Hospital and 51 in a private polyclinic. The mean size of the hernia defect in the inguinal, femoral and umbilical hernias was 2.5 cm (1-4 cm), while in the incisional hernias it was 4.5 cm (3-6 cm). The mean operating time was 2.4 hrs (2-6 hrs). There were no requirement for urinary drains. The mean follow-up was 18 months (0-36 months). The incidence of infection, chronic pain and recurrence was 0%. Three of the patients had complications: seroma in one patient with an incisional hernia and hematoma in two patients after inguinal hernia repair. The employment of PHS, UHS and 3DP devices, which have not yet been widely accepted in our hospitals, has had outstanding results in outpatient surgery. In addition, the type of anaesthesia and the 3D mesh construction prepare the way for a short hospital stay, smooth recovery and a swift return to normal activity.

  8. Reinforcement of a plate weakened by multiple holes with several patches for different types of plate-patch attachment

    KAUST Repository

    Zemlyanova, A.

    2014-01-24

    The most general situation of the reinforcement of a plate with multiple holes by several patches is considered. There is no restriction on the number and the location of the patches. Two types of patch attachment are considered: only along the boundary of the patch or both along the boundary of the patch and the boundaries of the holes which this patch covers. The unattached boundaries of the holes may be loaded with given in-plane stresses. The mechanical problem is reduced to a system of singular integral equations which can be further reduced to a system of Fredholm equations. A new numerical procedure for the solution of the system of singular integral equations is proposed in this paper. It is demonstrated on numerical examples that this procedure has advantages in the case of multiple patches and holes and allows achievement of better numerical convergence with less computational effort.

  9. Establishment of an in vitro Peyer's patch cell culture system correlative to in vivo study using intestine and screening of lactic acid bacteria enhancing intestinal immunity.

    Science.gov (United States)

    Jin, Hekui; Higashikawa, Fumiko; Noda, Masafumi; Zhao, Xingrong; Matoba, Yasuyuki; Kumagai, Takanori; Sugiyama, Masanori

    2010-01-01

    Some lactic acid bacteria (LAB) are known as representative of probiotics. To screen LAB effective to enhance intestinal immunity, in the present study, we developed an accurate and convenient in vitro evaluation system using Peyer's patch cells (PP-cells) isolated from the mice intestine. We observed that the amount of immunoglobulin A (IgA) produced by PP-cells co-cultured with LAB was well correlative to that in PP-cells, intestine and feces isolated from live mice after oral administration of LAB [correlation coefficient (r)=0.888, 0.883, and 0.920, respectively]. In addition, using this in vitro system, we suggest that the IgA level of PP-cells co-culturing with plant-derived LAB might be more enhanced than with animal-derived LAB.

  10. Generic patch inference

    DEFF Research Database (Denmark)

    Andersen, Jesper; Lawall, Julia

    2010-01-01

    A key issue in maintaining Linux device drivers is the need to keep them up to date with respect to evolutions in Linux internal libraries. Currently, there is little tool support for performing and documenting such changes. In this paper we present a tool, spdiff, that identifies common changes...... developers can use it to extract an abstract representation of the set of changes that others have made. Our experiments on recent changes in Linux show that the inferred generic patches are more concise than the corresponding patches found in commits to the Linux source tree while being safe with respect...

  11. A Microstripe Slotted Patch Antenna Using Amc

    Directory of Open Access Journals (Sweden)

    Manju Saini,

    2014-04-01

    Full Text Available Microstrip patch antenna offer an attractive solution to compact and ease-low-cost design of modern wireless communication system due to their many advantages as light weight and low volume, low profile, planer configuration which can be easily made conformal to low fabrication cost and capability of obtaining dual and triple frequency operations. A microstrip patch antenna with bandwidth enhancement by means of artificial magnetic conductor (AMC/electromagnetic band-gap structure (EBG is studied in this paper. The three different geometry shapes, the U, E and H are developed from rectangular patch. The antennas studied in this paper are simulated using sonnet software and results compared with the conventional rectangular patch antenna. The results obtained clearly shows that , bandwidth of conventional rectangular microstrip antenna can be enhanced has been studied

  12. Superficial Priming in Episodic Recognition

    Science.gov (United States)

    Dopkins, Stephen; Sargent, Jesse; Ngo, Catherine T.

    2010-01-01

    We explored the effect of superficial priming in episodic recognition and found it to be different from the effect of semantic priming in episodic recognition. Participants made recognition judgments to pairs of items, with each pair consisting of a prime item and a test item. Correct positive responses to the test item were impeded if the prime…

  13. Biocide patch tests

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Veien, Niels

    1985-01-01

    Routine patch testing with a series of 6 industrial biocides containing methylene-bis-thiocyanate (Cytox 3522), benzisothiazolin-3-one (BIT), chlorocresol (Preventol CMK), 2-n-octyl-4-isothiazolin-3-one (Kathon 893), polyhydroxymethylene monobenzylether (Preventol D2) or 1,3,5-tris (hydroxy-ethyl...

  14. Polar Cap Patch Dynamics

    Science.gov (United States)

    2013-04-25

    cap arcs Citation: Hosokawa, K., J. I. Moen, K. Shiokawa, and Y. Otsuka ( 2011 ), Motion of polar cap arcs , J. Geophys. Res. , 116 , A01305, doi...K., J. I. Moen, K. Shiokawa, and Y. Otsuka , (2011), Decay of polar cap patch, J. Geophys. Res., 116, A05308, doi:10.1029/2010JA016287, Abstract. We

  15. Century Tide Nicotine Patch

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Century Tide Nicotine Patch, a hi-tech smoking control therapy, is designed in accordance with the scientific principle of nicotine replacement. The therapy is promoted by the World Health Organization. Meanwhile, it also integrates traditional Chinese medical therapy and adopts advanced TTS technology.

  16. Lumbar subarachnoid hematoma following an epidural blood patch for meningeal puncture headache related to the implantation of an intrathecal drug delivery system.

    Science.gov (United States)

    Hustak, Erik C; Engle, Mitchell P; Viswanathan, Ashwin; Koyyalagunta, Dhanalakshmi

    2014-01-01

    Persistent meningeal puncture headache (MPH) is a known complication following both intentional and unintentional puncture of the dura mater.  We present a case of persistent MPH following implantation of an intrathecal drug delivery system (IDDS). Two separate epidural blood patches (EBP) were performed under radiographic guidance with contrast visualization of the epidural space on postoperative days 16 and 28, respectively. The case was complicated by the development of a symptomatic lumbar subarachnoid hematoma diagnosed on postoperative day 35. The patient subsequently underwent a laminectomy, evacuation of the hematoma, and explanation of the IDDS. This case illustrates a potential unique morbidity associated with the EBP in a patient with an IDDS. The report concludes with a brief review of MPH followed by a discussion of possible mechanisms underlying this complication.

  17. Prediction of the vibroacoustic response of a structure-liner-fluid system based on a patch transfer function approach and direct experimental subsystem characterisation

    CERN Document Server

    Albert, Christopher G; Nijman, Eugène; Rejlek, Jan

    2016-01-01

    The vibro-acoustic response of a structure-liner-fluid system is predicted by application of a patch impedance coupling methodology. In contrast to existing numerical approaches, impedance matrices of structure and liner are determined by a direct experimental approach, avoiding the requirement of material parameters. Emphasis is placed on poroelastic lining materials. The method accounts for surface input and transfer terms and for cross and cross-transfer terms through the specimen. A single test-rig characterisation procedure for layered poroelastic media is proposed. The specimen is considered as a single component -- no separation of layers is necessary. Problem specific boundary conditions for skeleton and fluid, which may cause non-reciprocal cross terms, are dealt with by the procedure. Methods of measurement for the assessment of impedance matrices are presented and their accuracy and limitations are discussed. An air gap correction method for surface impedance measurements is presented.

  18. Ileal Peyer's patches are not necessary for systemic B cell development and maintenance and do not contribute significantly to the overall B cell pool in swine.

    Science.gov (United States)

    Sinkora, Marek; Stepanova, Katerina; Butler, John E; Francis, David; Santiago-Mateo, Kristina; Potockova, Hana; Karova, Kristyna; Sinkorova, Jana

    2011-11-15

    Based on studies of sheep, ileal Peyer's patches (IPP) have been regarded as a type of primary lymphoid tissue similar to the bursa of Fabricius in chicken. Because bursectomy results in B cell deficiency, we wondered whether resection of the IPP of piglets would have a similar effect. Comparison of IPP-resected, surgical shams and untreated germ-free piglets, all of which were later colonized with a defined commensal flora, demonstrated that resection of the IPP did not alter the level and phenotype of B and T cells in lymphoid tissues and the blood 10 wk after surgery. Additionally, colonization of IPP caused a shift from the fetal type of lymphocyte distribution to the adult type that is characterized by prevalence of B cells, with many of them representing IgA(+) switched B cells or displaying a more mature CD2(-)CD21(+) and CD2(-)CD21(-) phenotype. Moreover, colonization leads to appearance of effector CD4(+)CD8(+) αβ T helper and CD2(+)CD8(-) γδ T cells. Comparison of germ-free with colonized pigs and experiments utilizing surgical transposition of jejunal Peyer's patch into terminal ileum or construction of isolated ileal loops indicated that lymphocyte development in IPP is dependent on colonization. Although our studies confirmed higher mitotic and apoptotic rates in IPP, they failed to identify any cell populations that resemble developing B lineage cells in the bone marrow. These results indicate that porcine IPP are not required for systemic B cell generation or maintenance, but they are secondary lymphoid tissue that appears important in immune responses to colonizing bacteria.

  19. Security of Patched DNS

    CERN Document Server

    Herzberg, Amir

    2012-01-01

    In spite of the availability of DNSSEC, which protects against cache poisoning even by MitM attackers, many caching DNS resolvers still rely for their security against poisoning on merely validating that DNS responses contain some 'unpredictable' values, copied from the re- quest. These values include the 16 bit identifier field, and other fields, randomised and validated by different 'patches' to DNS. We investigate the prominent patches, and show how attackers can circumvent all of them, namely: - We show how attackers can circumvent source port randomisation, in the (common) case where the resolver connects to the Internet via different NAT devices. - We show how attackers can circumvent IP address randomisation, using some (standard-conforming) resolvers. - We show how attackers can circumvent query randomisation, including both randomisation by prepending a random nonce and case randomisation (0x20 encoding). We present countermeasures preventing our attacks; however, we believe that our attacks provide ...

  20. Patch test with preservatives

    Directory of Open Access Journals (Sweden)

    Kar Sumit

    1992-01-01

    Full Text Available Of the 705 patients patch tested between March 88 to March 91, 317 were tested for sensitivity to preservatives with antigens obtained from Chemo technique AB, Sweden. Paraben was the commonest sensitizer (22.4% followed by Groton B K (8.1% and Triclosan (6.5%. We stress the need to consider these allergens as source of dermatitis and advocate complete labelling of topical preparations marketed.

  1. Adsorção de metais pesados após calagem superficial em um Latossolo Vermelho sob sistema de plantio direto Heavy metals adsorption after surface lime in a Rhodic Hapludox under no-tillage system

    Directory of Open Access Journals (Sweden)

    Helio Antonio Wood Joris

    2012-03-01

    Full Text Available A influência da correção da acidez do solo sob sistema plantio direto (SPD na adsorção de metais pesados é pouco conhecida. Este trabalho teve o objetivo de avaliar a adsorção de cádmio (Cd, níquel (Ni, cobre (Cu e zinco (Zn em um Latossolo Vermelho distrófico textura argilosa sem e com calagem superficial (4,5 t ha-1 de calcário, manejado no SPD. O experimento foi instalado em 1998, no município de Ponta Grossa, PR. Após 10 anos, amostras de solo foram coletadas nas camadas 0-5; 5-10 e 10-20 cm e foram adicionadas doses crescentes de 0 a 180 mg L-1 de Cd e Ni e de 0 a 180 mg L-1 de Cu e Zn, em sistemas competitivos. Após equilíbrio, foi determinada a quantidade de metais adsorvidos. A calagem superficial no SPD aumentou o pH do solo em todas as camadas estudadas, resultando em incremento na adsorção de Cu, Zn, Cd e Ni, principalmente, na camada superficial. Ainda, a calagem alterou a dinâmica dos metais pesados no solo, sendo uma estratégia eficiente com potencial para minimizar problemas ambientais com Cu, Zn, Cd e Ni no SPD.There are few researches about control of soil acidy and adsorption of heavy metals in no-till system (NTS. The aim of this study was evaluate the cadmium (Cd, nickel (Ni, copper (Cu and zinc (Zn adsorption in a Rhodic Hapludox, clayey, without and with surface liming (4.5 t ha-1 under NTS. The experiment was established in Ponta Grossa, PR, in 1998. After 10 years, soil samples were collected to adsorption study. Doses of 0 to 180 mg L-1 of Cd and Ni, and of 0 to 180 mg L-1 of Cu and Zn were added, in competitive systems. After the equilibrium, the quantity of heavy metals was measured. Surface liming increased soil pH in all studied layers, resulting in improve of Cu, Zn, Cd and Ni adsorptions, mostly in the superficial layer. Moreover, surface liming changed dynamics of heavy metals in soil, being an efficient strategy to minimize environmental problems associate with Cd, Ni, Cu and Zn in NTS.

  2. Superficie

    OpenAIRE

    Corna, Pablo María

    2015-01-01

    En la época posclásica del derecho romano se buscó, por parte del Estado y ciudadanos, utilizar ciertos terrenos que formaban parte de su patrimonio para arrendarlos por largo término —y a veces a perpetuidad— a personas que tenían el derecho de edificar o plantar mediante el pago de un precio llamado pensio o solárium. En el siglo II de nuestra era ya era utilizado para asentar tribus romanizadas en la frontera del imperio como para el cultivo de vid y los olivos que demoran varios...

  3. Superficie

    OpenAIRE

    Corna, Pablo María

    2015-01-01

    En la época posclásica del derecho romano se buscó, por parte del Estado y ciudadanos, utilizar ciertos terrenos que formaban parte de su patrimonio para arrendarlos por largo término —y a veces a perpetuidad— a personas que tenían el derecho de edificar o plantar mediante el pago de un precio llamado pensio o solárium. En el siglo II de nuestra era ya era utilizado para asentar tribus romanizadas en la frontera del imperio como para el cultivo de vid y los olivos que demoran varios años e...

  4. Stress-In-Motion (SIM) system for capturing tri-axial tyre-road interaction in the contact patch

    CSIR Research Space (South Africa)

    De Beer, Morris

    2013-08-01

    Full Text Available A unique measuring system for the quantification of tri-axial (3-D) tyre contact force (or stress) distributions was designed, developed and used in several studies since 1994. The uniqueness of the system is defined by a textured measuring surface...

  5. A PROSPECTIVE, COMPARATIVE STUDY OF TENSION FREE HERNIOPLASTY USING PROLENE HERNIA SYSTEM (PHS AND LICHTENSTEIN PATCH METHOD (LPM IN INGUINAL HERNIA

    Directory of Open Access Journals (Sweden)

    Suchi

    2016-04-01

    Full Text Available BACKGROUND Inguinal hernia repair in men is one of the most common operations in general surgery. Techniques of surgical repair include open suture, open mesh and laparoscopic techniques. Successful hernia surgery involves minimum risk of surgery, anaesthesia, minimum tissue trauma, hospitalization, complications and recurrence. The most effective surgical treatment is unknown. The present study was undertaken to compare the results of tension free hernioplasty using Prolene Hernia System and Lichtenstein Patch Method and to find out the benefits of former over latter if any. MATERIALS AND METHODS This prospective study was conducted on adult male patients admitted in the Surgical Department of Government Medical College, Jammu, for elective surgery of inguinal hernia (Direct/Indirect/Both. Exclusion criteria included age below 18 years, multiple surgical procedures in the groin, recurrent hernia, femoral hernia and strangulated hernia. Twenty-five patients each were randomly distributed to undergo either Prolene Hernia System Repair (PHS or Lichtenstein Patch Method (LPM. Comparison was performed between the two techniques on basis of duration of surgery, postoperative pain, ambulation, hospital stay, complications and recurrence. Pain was assessed by Visual Analogue Scale (VAS. The data analysed using SPSS. RESULTS Mean time duration in operation on patients using PHS was statistically less as compared to the LMP. Pain scores using Visual Analogue Scale (VAS were comparable in both the groups. There were only 2 complications in PHS group as compared to 10 in LPM group, the difference being statistically significant. Mean hospital stay was less for PHS group as compared to LPM group, (the difference being statistically significant. There existed no significant difference in terms of return to activity in both the groups. There was no recurrence in the period of follow-up of 6 to 12 months in any patient in both the groups. CONCLUSION Prolene

  6. Surface patterning of nanoparticles with polymer patches

    Science.gov (United States)

    Choueiri, Rachelle M.; Galati, Elizabeth; Thérien-Aubin, Héloïse; Klinkova, Anna; Larin, Egor M.; Querejeta-Fernández, Ana; Han, Lili; Xin, Huolin L.; Gang, Oleg; Zhulina, Ekaterina B.; Rubinstein, Michael; Kumacheva, Eugenia

    2016-10-01

    Patterning of colloidal particles with chemically or topographically distinct surface domains (patches) has attracted intense research interest. Surface-patterned particles act as colloidal analogues of atoms and molecules, serve as model systems in studies of phase transitions in liquid systems, behave as ‘colloidal surfactants’ and function as templates for the synthesis of hybrid particles. The generation of micrometre- and submicrometre-sized patchy colloids is now efficient, but surface patterning of inorganic colloidal nanoparticles with dimensions of the order of tens of nanometres is uncommon. Such nanoparticles exhibit size- and shape-dependent optical, electronic and magnetic properties, and their assemblies show new collective properties. At present, nanoparticle patterning is limited to the generation of two-patch nanoparticles, and nanoparticles with surface ripples or a ‘raspberry’ surface morphology. Here we demonstrate nanoparticle surface patterning, which utilizes thermodynamically driven segregation of polymer ligands from a uniform polymer brush into surface-pinned micelles following a change in solvent quality. Patch formation is reversible but can be permanently preserved using a photocrosslinking step. The methodology offers the ability to control the dimensions of patches, their spatial distribution and the number of patches per nanoparticle, in agreement with a theoretical model. The versatility of the strategy is demonstrated by patterning nanoparticles with different dimensions, shapes and compositions, tethered with various types of polymers and subjected to different external stimuli. These patchy nanocolloids have potential applications in fundamental research, the self-assembly of nanomaterials, diagnostics, sensing and colloidal stabilization.

  7. Utility of Duranta, a wireless patch-type electrocardiographic monitoring system developed in Japan, in detecting covert atrial fibrillation in patients with cryptogenic stroke

    Science.gov (United States)

    Akiyama, Hisanao; Nukui, Saki; Araga, Takashi; Hoshino, Masashi; Tanaka, Keita; Kashima, Satoru; Sasaki, Rie; Uchino, Kenji; Hasegawa, Yasuhiro

    2017-01-01

    Abstract Rationale: Subcutaneous implantable electrocardiographs are highly effective in detecting covert atrial fibrillation (AF) in cryptogenic stroke. However, these invasive devices are not indicated for all cryptogenic stroke patients, and noninvasive improvements over conventional Holter-type ambulatory electrocardiography are needed. We evaluated the clinical application and effectiveness of Duranta (ImageONE Co., Ltd.), a wireless patch-type electrocardiographic monitoring system developed in Japan for chronically ill patients or home-based patients at the end of life. A Duranta device was used to detect covert AF in patients with acute ischemic stroke of undetermined source with no sign of AF during cardiographic monitoring ≥24 hours postadmission. Patient concerns: A 72-year-old man with severe aortic stenosis was admitted to our hospital with dysarthria and right upper limb weakness. Diffusion-weighted plain head magnetic resonance imaging (MRI) showed acute cerebral infarctions across the left middle cerebral artery territory. Twelve-lead electrocardiography, Holter-type ambulatory electrocardiography, and cardiographic monitoring for ≥24 hours revealed no AF, indicating a probable diagnosis of artery-to-artery embolism following left common carotid artery stenosis detected by carotid ultrasound imaging and cerebral angiography. Interventions: However, because of high blood brain natriuretic peptide (BNP) and valvular heart disease, continuous monitoring using Duranta was performed from the 2nd to 13th days after onset to exclude possible cardioembolic stroke. Waveform and heart rate trend graph analysis showed paroxysmal AF (PAF) occurred on the 5th and 9th days after onset. PAF did not occur at any other time during the observation period. The quality of the cardiograms sufficed for analysis and diagnosis of AF. The lightweight compact device can be placed quickly with no movement restriction. These features and our findings show the

  8. The tritrophic system hyptis suaveolens (Lamiaceae - agromyzid leafminers (Diptera: Agromyzidae - parasitoids (Hymenoptera: effects of herbivore density, host plant patch size, and habitat complexity on parasitism rate

    Directory of Open Access Journals (Sweden)

    Jarbas Marcal de Queiroz

    2009-06-01

    Full Text Available In this study a tritrophic system was evaluated to measure the contributions of the insect host density and its host plant concentration in simple and diversified habitat on the rate of parasitism. The system was composed of the plant Hyptis suaveolens, two species of agromyzid leafminers, and three morphospecies of parasitoids. The parasitism rate, patch size, and habitat complexity were found to be interdependent. If only the habitat complexity or patch size was take into account the differences in parasitism rate are not significant, although habitat diversity seemed to contribute more than the host plant concentration to increase the parasitism rate. The leaves or plants with different number of mines were equally attacked by the parasitoids. The results were representative of what happened to the leafminers at different host plant densities under the homogeneous and heterogeneous habitat condition. This work could help to reinforce the idea of the importance of the plant diversity for enhancing the biological control of the pests by the parasitoids in the managed ecosystems.Foi avaliado um sistema tritrófico para medir os efeitos da densidade de insetos minadores e a concentração da planta hospedeira em habitats simples e diversificados sobre a taxa de parasitismo. O sistema era composto pela planta Hyptis suaveolens, duas espécies de agromizídeos minadores de folhas e três morfoespécies de parasitóides. A taxa de parasitismo, tamanho da mancha e a complexidade do habitat foram interdependentes. Se levarmos em consideração apenas a complexidade ou tamanho de mancha, as diferenças na taxa de parasitismo não foram significativas, embora a diversidade de habitat pareça ter contribuido mais do que a concentração da planta hospedeira para aumentar a taxa de parasitismo. Folhas ou plantas com diferentes números de minas foram igualmente parasitadas. Nossos resultados são representativos do que acontece com insetos minadores em

  9. Patch antenna terahertz photodetectors

    Energy Technology Data Exchange (ETDEWEB)

    Palaferri, D.; Todorov, Y., E-mail: yanko.todorov@univ-paris-diderot.fr; Chen, Y. N.; Madeo, J.; Vasanelli, A.; Sirtori, C. [Laboratoire Matériaux et Phénomènes Quantiques, Université Paris Diderot, Sorbonne Paris Cité, CNRS-UMS 7162, 75013 Paris (France); Li, L. H.; Davies, A. G.; Linfield, E. H. [School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT (United Kingdom)

    2015-04-20

    We report on the implementation of 5 THz quantum well photodetector exploiting a patch antenna cavity array. The benefit of our plasmonic architecture on the detector performance is assessed by comparing it with detectors made using the same quantum well absorbing region, but processed into a standard 45° polished facet mesa. Our results demonstrate a clear improvement in responsivity, polarization insensitivity, and background limited performance. Peak detectivities in excess of 5 × 10{sup 12} cmHz{sup 1/2}/W have been obtained, a value comparable with that of the best cryogenic cooled bolometers.

  10. Characteristics of patients patch tested in the European Surveillance System on Contact Allergies (ESSCA) network, 2009-2012

    DEFF Research Database (Denmark)

    Uter, Wolfgang; Gefeller, Olaf; Giménez-Arnau, Ana

    2015-01-01

    from 63 530 consultations collected by 53 departments from 12 countries participating in the European Surveillance System on Contact Allergies (ESSCA) ( www.essca-dc.org) between 2009 and 2012. RESULTS: Considerable variation in the prevalence of the MOAHLFA factors between departments was found...

  11. Superficial dose evaluation of four dose calculation algorithms

    Science.gov (United States)

    Cao, Ying; Yang, Xiaoyu; Yang, Zhen; Qiu, Xiaoping; Lv, Zhiping; Lei, Mingjun; Liu, Gui; Zhang, Zijian; Hu, Yongmei

    2017-08-01

    Accurate superficial dose calculation is of major importance because of the skin toxicity in radiotherapy, especially within the initial 2 mm depth being considered more clinically relevant. The aim of this study is to evaluate superficial dose calculation accuracy of four commonly used algorithms in commercially available treatment planning systems (TPS) by Monte Carlo (MC) simulation and film measurements. The superficial dose in a simple geometrical phantom with size of 30 cm×30 cm×30 cm was calculated by PBC (Pencil Beam Convolution), AAA (Analytical Anisotropic Algorithm), AXB (Acuros XB) in Eclipse system and CCC (Collapsed Cone Convolution) in Raystation system under the conditions of source to surface distance (SSD) of 100 cm and field size (FS) of 10×10 cm2. EGSnrc (BEAMnrc/DOSXYZnrc) program was performed to simulate the central axis dose distribution of Varian Trilogy accelerator, combined with measurements of superficial dose distribution by an extrapolation method of multilayer radiochromic films, to estimate the dose calculation accuracy of four algorithms in the superficial region which was recommended in detail by the ICRU (International Commission on Radiation Units and Measurement) and the ICRP (International Commission on Radiological Protection). In superficial region, good agreement was achieved between MC simulation and film extrapolation method, with the mean differences less than 1%, 2% and 5% for 0°, 30° and 60°, respectively. The relative skin dose errors were 0.84%, 1.88% and 3.90%; the mean dose discrepancies (0°, 30° and 60°) between each of four algorithms and MC simulation were (2.41±1.55%, 3.11±2.40%, and 1.53±1.05%), (3.09±3.00%, 3.10±3.01%, and 3.77±3.59%), (3.16±1.50%, 8.70±2.84%, and 18.20±4.10%) and (14.45±4.66%, 10.74±4.54%, and 3.34±3.26%) for AXB, CCC, AAA and PBC respectively. Monte Carlo simulation verified the feasibility of the superficial dose measurements by multilayer Gafchromic films. And the rank

  12. Improving Saliency Models by Predicting Human Fixation Patches

    KAUST Repository

    Dubey, Rachit

    2015-04-16

    There is growing interest in studying the Human Visual System (HVS) to supplement and improve the performance of computer vision tasks. A major challenge for current visual saliency models is predicting saliency in cluttered scenes (i.e. high false positive rate). In this paper, we propose a fixation patch detector that predicts image patches that contain human fixations with high probability. Our proposed model detects sparse fixation patches with an accuracy of 84 % and eliminates non-fixation patches with an accuracy of 84 % demonstrating that low-level image features can indeed be used to short-list and identify human fixation patches. We then show how these detected fixation patches can be used as saliency priors for popular saliency models, thus, reducing false positives while maintaining true positives. Extensive experimental results show that our proposed approach allows state-of-the-art saliency methods to achieve better prediction performance on benchmark datasets.

  13. Understanding patch departure rules for large carnivores: lion movements support a patch-disturbance hypothesis.

    Science.gov (United States)

    Valeix, Marion; Chamaillé-Jammes, Simon; Loveridge, Andrew J; Davidson, Zeke; Hunt, Jane E; Madzikanda, Hillary; Macdonald, David W

    2011-08-01

    We test two hypotheses that could account for patch departure by large mammalian carnivores. One hypothesis is the unsuccessful-hunt hypothesis, where carnivores leave an area after an unsuccessful hunt but continue hunting in the same area after a successful hunt. The second hypothesis is the patch-disturbance hypothesis, where carnivores depart the area after a successful hunt because of behavioral responses of prey to predator presence. We used global positioning system collars to monitor the movements of African lions (Panthera leo) and identified their kill sites to distinguish between these two hypotheses. Lions moved to a different area (≥ 5 km away) after 87% of the kills, which supports the patch-disturbance hypothesis for patch-departure behavior of large mammalian carnivores.

  14. Collaboratively Patching Linked Data

    CERN Document Server

    Knuth, Magnus; Sack, Harald

    2012-01-01

    Today's Web of Data is noisy. Linked Data often needs extensive preprocessing to enable efficient use of heterogeneous resources. While consistent and valid data provides the key to efficient data processing and aggregation we are facing two main challenges: (1st) Identification of erroneous facts and tracking their origins in dynamically connected datasets is a difficult task, and (2nd) efforts in the curation of deficient facts in Linked Data are exchanged rather rarely. Since erroneous data often is duplicated and (re-)distributed by mashup applications it is not only the responsibility of a few original publishers to keep their data tidy, but progresses to be a mission for all distributers and consumers of Linked Data too. We present a new approach to expose and to reuse patches on erroneous data to enhance and to add quality information to the Web of Data. The feasibility of our approach is demonstrated by example of a collaborative game that patches statements in DBpedia data and provides notifications ...

  15. Statistics for Patch Observations

    Science.gov (United States)

    Hingee, K. L.

    2016-06-01

    In the application of remote sensing it is common to investigate processes that generate patches of material. This is especially true when using categorical land cover or land use maps. Here we view some existing tools, landscape pattern indices (LPI), as non-parametric estimators of random closed sets (RACS). This RACS framework enables LPIs to be studied rigorously. A RACS is any random process that generates a closed set, which encompasses any processes that result in binary (two-class) land cover maps. RACS theory, and methods in the underlying field of stochastic geometry, are particularly well suited to high-resolution remote sensing where objects extend across tens of pixels, and the shapes and orientations of patches are symptomatic of underlying processes. For some LPI this field already contains variance information and border correction techniques. After introducing RACS theory we discuss the core area LPI in detail. It is closely related to the spherical contact distribution leading to conditional variants, a new version of contagion, variance information and multiple border-corrected estimators. We demonstrate some of these findings on high resolution tree canopy data.

  16. Strategic Analysis for Patch Ltd.

    OpenAIRE

    Louis, Owen

    2012-01-01

    This paper is a strategic analysis for the start-up Patch Ltd. Patch has developed innovative products for growing produce in homes and will compete in the consumer containergrowing industry. The industry and the company are introduced along with urban agriculture trends. The industry is analysed using Porter’s 5 forces analysis, and a competitive analysis compares Patch to its competitors in key success factors found in the 5 forces analysis. A strategy is developed using opportunities and t...

  17. A rare variant of the superficial ulnar artery, and its clinical implications: a case report

    Directory of Open Access Journals (Sweden)

    Senanayake Kithsiri J

    2007-11-01

    Full Text Available Abstract The superficial ulnar artery is a rare variation of the upper limb arterial system that arises from the brachial or axillary artery and runs superficial to the muscles arising from the medial epicondyle 123. The incidence is about 0.7 to 7% 145. In our routine dissections we found a superficial ulnar artery, which crossed the cubital fossa superficial to the bicipital aponeurosis making it highly vulnerable to intra-arterial injection. This is a rare variation that every medical and nursing staff member should know about.

  18. Phosphorus loss by surface runoff in no-till system under mineral and organic fertilization Perda de fósforo via escoamento superficial no sistema plantio direto sob adubação mineral e orgânica

    Directory of Open Access Journals (Sweden)

    Oromar João Bertol

    2010-02-01

    Full Text Available The no-till system has been intensively used in the state of Paraná, Brazil, and it has increased the nutrients level at the soil surface. This has contributed for nutrient losses via runoff and consequently, off-site water pollution. The objective of this study was to evaluate phosphorus loss in surface runoff by simulated rainfall on an Oxisol, under no-till system following application of mineral fertilizer and liquid swine manure. Nitrogen, soil and water losses from the same study are reported in a separated paper. The application of liquid swine manure, compared with mineral fertilization, increased runoff concentration of total P, particulate P and dissolved reactive P by 193%, 111% and 506%, respectively, averaged for all rainfall intensities. Independently on the fertilizer source, the highest rainfall intensity provided the greatest concentration and loads of P in runoff.O sistema plantio direto tem sito intensivamente utilizado no Estado do Paraná Brasil o qual tem aumentado os níveis de nutrientes na superfície do solo. Isto tem contribuído para a perda de nutrientes via escoamento superficial e consequentemente com a poluição não pontual das águas. Avaliou-se a perda de fósforo via escoamento superficial ocasionado por chuva simulada sobre um Latossolo originário de basalto, em sistema plantio direto submetido à aplicação de fertilizante mineral e dejeto líquido de suíno. As perdas de nitrogênio, solo e água deste mesmo estudo foram publicadas em outro artigo. A aplicação de dejeto líquido suíno, comparado com o fertilizante mineral, aumentou a concentração de P total, P particulado e P dissolvido reativo em 193%, 111% e 506%, respectivamente, na média das chuvas. Independentemente da fonte de fertilizante, a chuva de maior intensidade proporcionou maior concentração e quantidade perdida de P no escoamento superficial.

  19. Patch based predation in a southern Appalachian stream

    Science.gov (United States)

    C.A. Gibson; R.E. Ratajezak; G.D. Grossman

    2004-01-01

    Streams are characterized by high degrees of patchiness that could influence the role of predators in these systems. Here we assess the impact of predatory benthic fishes on benthic macroinvertebrate density, biomass, and community structure at the patch scale in a fourth order stream in the southern Appalachians. We tested the role of predation in two different patch...

  20. Superficial Type of Multiple Basal Cell Carcinomas: Detailed Comparative Study of Its Dermoscopic and Histopathological Findings

    Directory of Open Access Journals (Sweden)

    Akiko Hirofuji

    2011-01-01

    Full Text Available We investigated in detail the dermoscopic and histopathological findings in a case of a superficial type of multiple basal cell carcinomas (BCCs. These multiple lesions (occurring in the chest, neck, and back showed three different findings, respectively. Dermoscopy of the erythematous and brown-colored patch on the anterior chest showed spoke wheel areas, and the histopathological cross-section revealed vertical spoke wheel structures. In the black- and brown-colored patch at the neck, the dermatoscopy showed a maple leaf-like structure, which was in accordance with the strengthening of the histological lateral connection of the lesion. The brown-colored patch of the lateral back histologically showed irregularly enlarged spoke wheel-like areas with peripheral increased melanin pigments, which correlated with the dark black color of dermoscopic maple leaf-like areas. The vertical spoke wheel areas by dermatoscopy revealed a horizontal spoke wheel structure by histopathology.

  1. Late sequelae of superficial irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Hood, I.C.; Young, J.E.

    1984-10-01

    Superficial irradiation results in well recognized late sequelae including not only sclerosis and atrophy of skin and subcutaneous tissue, but also the development of benign and malignant tumors of skin and adjacent structures. The long latency between irradiation and its late effects allowed the early uncontrolled use of radiation treatment for benign conditions. The subsequent recognition of the causal relationship between tumors and previous irradiation has restricted its use to more appropriate purposes, although it is possible that it is still overused in some areas of dermatologic practice. Clinicians need to be aware of the time interval between irradiation and the development of its late sequelae, and the incidence of these sequelae. Appropriate irradiation exposure history should be a part of the evaluation of every patient.

  2. Aplicação superficial de calcário e diferentes resíduos em soja cultivada no sistema plantio direto Surface application of limestone and different residues on soybean grown in no-till system

    Directory of Open Access Journals (Sweden)

    Juliano Corulli Corrêa

    2009-01-01

    Full Text Available A prática da correção da acidez do solo pela aplicação superficial de corretivos sobre a palha no sistema plantio direto se restringe ao calcário, não havendo maiores estudos em relação à escória de aciaria, lama cal e lodo de esgoto centrifugado. O objetivo do trabalho foi avaliar os índices de acidez do solo e a produtividade da soja em função da aplicação superficial de lodo de esgoto centrifugado, lama cal, escória de aciaria e calcário dolomítico. O trabalho foi desenvolvido em Latossolo Vermelho distrófico, durante os anos agrícolas de 2002 a 2005, sob sistema plantio direto. Os tratamentos constituíram da aplicação superficial de escória de aciaria (E, lama cal (Lcal, lodo de esgoto centrifugado (LC, calcário dolomítico e sem aplicação de corretivo, em delineamento em blocos ao acaso, com quatro repetições. A aplicação superficial de escória de aciaria, lama cal e lodo de esgoto centrifugado permite a correção da acidez do solo, o deslocamento do Ca2+, o aumento da saturação por bases e redução do Al3+ até 40 cm, e para o calcário, até 20 cm, fatores que condicionaram o aumento da produtividade da soja para os tratamentos LC, E e Lcal em 2003/2004 e 2004/2005 e para LC e E em 2002/2003 no sistema plantio direto.The practice of correcting soil acidity by surface application of pH-correcting materials on crop residues in the no-till system is restricted to limestone. No further studies are available on the use of steel slag, lime mud, and centrifuged sewage sludge. The objective of this study was to evaluate soil acidity and yield of soybean as a function of surface application of centrifuged sewage sludge, lime mud, steel slag, and dolomitic limestone. The study was conducted on a dystrophic Clayey Rhodic Hapludox soil, during the 2002_2005 cropping seasons, under notill system. Treatments consisted on surface application of slag _ E, lime mud _ Lcal, centrifuged sewage sludge _ LC, dolomitic

  3. Increasing the spatial scale of process-based agricultural systems models by representing heterogeneity: The case of urine patches in grazed pastures

    DEFF Research Database (Denmark)

    Snow, Val O.; Cichota, R; McAuliffe, John

    2017-01-01

    We sought to extend the spatial scale of soil-plant models by including, rather than ignoring, heterogeneity using the deposition of urine patches as an example. Our “pseudo-patches” approach preserves the most important biophysical effects but is computationally-tractable within a multi......-paddock simulation. It explicitly preserves the soil carbon and nitrogen heterogeneity but does not require independent simulation of soil water and plant processes and is temporal in that the patches of heterogeneity can appear and disappear during the simulation. The approach was tested through comparison...

  4. Effect of sodium hypochlorite on the bond strength of an adhesive system to superficial and deep dentin Efeito do hipoclorito de sódio na resistência de união de um sistema adesivo na dentina superficial e profunda

    Directory of Open Access Journals (Sweden)

    Ninoshka Uceda-Gómez

    2003-09-01

    Full Text Available The objective of this study was to evaluate the bond strength to superficial (SU and deep (D dentin, accessed via apical (DA or occlusal (DO, using One-Step adhesive system applied according to the manufacturer's instructions (C or following deproteinization with 10% sodium hypochlorite (H for 60s, after acid etching. Three sound extracted human molars were prepared for each experimental condition. Restorations were performed using Z100 in 2mm increments, each one being light-cured for 40s. Teeth were longitudinally sectioned to obtain stick-shaped specimens with a cross-sectional area of 0.8mm², which were submitted to bond strength test (0.6mm/min. Results obtained after statistical analysis using a two-way ANOVA (substrate vs. surface treatment and Tukey's test were: SU (35.4 ± 12.3, DO (26.5 ± 8.5, DA (26.1 ± 10.2 following conventional surface treatment, and SU (28.82 ± 12.7, DO (24.3 ± 8.3 and DA (23.5 ± 8.5, after surface treatment using sodium hypochlorite. The interaction of the factors was not significant (p>0.05. However, the main factors were significant (pDO=DA. The conventional surface treatment resulted in higher bond strength values than the sodium hypochlorite treatment (pO objetivo foi avaliar a resistência de união (RU de dentina superficial (SU e profunda (P, obtida por acesso apical (PA ou oclusal (PO, ao adesivo One-Step com (H ou sem aplicação de hipoclorito de sódio a 10% (C após o condicionamento ácido. Para os 6 grupos foram utilizados seis molares hígidos. Nos grupos SUC, PAC e POC, o adesivo e a resina Z100 foram aplicados. Nos grupos SUH, PAH e POH, após condicionamento, aplicou-se H por 60s, adesivo e Z100. Os dentes foram fatiados em cortes paralelos e perpendiculares para a obtenção de cp de 0,8mm² e testados sob tração (0,6mm/min. Os valores de RU foram submetidos a ANOVA de dois fatores. Não se detectou diferença para a interação (p=0,209, porém os fatores principais foram diferentes (p

  5. Polymer concrete patching materials

    Energy Technology Data Exchange (ETDEWEB)

    Fontana, J.J.

    1977-09-01

    The increased use of deicing salts is causing rapid deterioration of portland cement concrete bridge decks. Soluble chlorides cause corrosion of the steel reinforcing rods with a corresponding increase in volume of the rods. This expansion causes stresses in the concrete which result in delaminations and surface spalling. The repair of surface spalls with portland cement concrete can only be made if traffic can be avoided for several days. A patching material which would allow traffic to resume over the repaired area in a few hours was needed. Polymer concrete (PC) was developed to repair deteriorated portland cement concrete. Polymer concrete is defined as a composite material in which the aggregate is bound together in a dense matrix with a polymer binder. The aggregate is mixed with a monomer mixture and subsequently cured in place. Polymer concrete combines the premix characteristics of portland cement concrete with high strength, long term durability properties and fast cure times. PC placed at temperatures between 35/sup 0/F and 95/sup 0/F attains strengths greater than 5000 psi in 2 hours. The high early strength of PC is suitable for use in the repair of highway structures where traffic conditions allow closing of the area for only a few hours.

  6. Toric degenerations of Bezier patches

    CERN Document Server

    Garcia-Puente, Luis David; Zhu, Chungang

    2010-01-01

    The control polygon of a Bezier curve is well-defined and meaningful---there is a sequence of weights under which the limiting position of the curve is the control polygon. For a Bezier surface patch, there are many possible polyhedral control structures, and none are canonical. We propose a not necessarily polyhedral control structure for surface patches, regular control surfaces, which are certain C^0 spline surfaces. While not unique, regular control surfaces are exactly the possible limiting positions of a Bezier patch when the weights are allowed to vary, but the control points are fixed.

  7. Tromboflebite superficial: epidemiologia, fisiopatologia, diagnóstico e tratamento Superficial thrombophlebitis: epidemiology, physiopathology, diagnosis and treatment

    Directory of Open Access Journals (Sweden)

    Marcone Lima Sobreira

    2008-06-01

    Full Text Available A tromboflebite superficial de membros inferiores é doença de ocorrência comum, estando associada a diversas condições clínicas e cirúrgicas. Historicamente considerada doença benigna, devido à sua localização superficial e ao fácil diagnóstico, o tratamento foi conservador durante muito tempo, na maioria dos casos. Entretanto, relatos recentes de freqüências altas de complicações tromboembólicas associadas - 22 a 37% para trombose venosa profunda e até 33% para embolia pulmonar - alertaram para a necessidade de abordagens diagnósticas e terapêuticas mais amplas, visando diagnosticar e tratar essas possíveis complicações. A possibilidade da coexistência dessas e de outras desordens sistêmicas (colagenoses, neoplasias, trombofilias interfere na avaliação e influencia a conduta terapêutica, que pode ser clínica, cirúrgica ou combinada. No entanto, devido à falta de ensaios clínicos controlados e às incertezas quanto a sua história natural, o diagnóstico e o tratamento da tromboflebite superficial continuam indefinidos. Neste trabalho, foi feita uma revisão da literatura analisando-se a epidemiologia, fisiopatologia e estado atual do diagnóstico e tratamento da tromboflebite superficial.Superficial thrombophlebitis of the lower limbs is a commonly occurring disease, and it is associated with various clinical and surgical conditions. Historically considered to be a benign disease due to its superficial location and easy diagnosis, its treatment was, for a long time, conservative in most cases. Nevertheless, recent reports of high frequency and associated thromboembolic complications, which vary from 22 to 37% for deep venous thrombosis and up to 33% for pulmonary embolism, have indicated the need for broader diagnostic and therapeutic approaches in order to diagnose and treat such possible complications. The possibility of coexistence of these and other systemic disorders (collagenosis, neoplasia, thrombophilia

  8. Cell-Detection Technique for Automated Patch Clamping

    Science.gov (United States)

    McDowell, Mark; Gray, Elizabeth

    2008-01-01

    A unique and customizable machinevision and image-data-processing technique has been developed for use in automated identification of cells that are optimal for patch clamping. [Patch clamping (in which patch electrodes are pressed against cell membranes) is an electrophysiological technique widely applied for the study of ion channels, and of membrane proteins that regulate the flow of ions across the membranes. Patch clamping is used in many biological research fields such as neurobiology, pharmacology, and molecular biology.] While there exist several hardware techniques for automated patch clamping of cells, very few of those techniques incorporate machine vision for locating cells that are ideal subjects for patch clamping. In contrast, the present technique is embodied in a machine-vision algorithm that, in practical application, enables the user to identify good and bad cells for patch clamping in an image captured by a charge-coupled-device (CCD) camera attached to a microscope, within a processing time of one second. Hence, the present technique can save time, thereby increasing efficiency and reducing cost. The present technique involves the utilization of cell-feature metrics to accurately make decisions on the degree to which individual cells are "good" or "bad" candidates for patch clamping. These metrics include position coordinates (x,y) in the image plane, major-axis length, minor-axis length, area, elongation, roundness, smoothness, angle of orientation, and degree of inclusion in the field of view. The present technique does not require any special hardware beyond commercially available, off-the-shelf patch-clamping hardware: A standard patchclamping microscope system with an attached CCD camera, a personal computer with an imagedata- processing board, and some experience in utilizing imagedata- processing software are all that are needed. A cell image is first captured by the microscope CCD camera and image-data-processing board, then the image

  9. Silicon superficial texturing bypulsed laser

    Directory of Open Access Journals (Sweden)

    Ponce, L.

    1998-04-01

    Full Text Available Texturing of silicon surfaces with pulsed laser is made. The method is based on the formation of laser- induced periodic surface structure (LIPSS. The process is temporary characterized through the dynamic reflectance, thus determining the formation threshold of the structure. Relation between the different textures and the spectral reflectance of the samples before and after the treatment is also characterized. The mean value of spectral reflectance decreases up to a 6 %.

    Se realiza el texturado de superficies de silicio con un láser pulsado mediante la formación de una estructura periódica inducida por láser (LIPSS. Se caracteriza el proceso mediante reflectancia dinámica, determinándose el umbral de formación de la estructura. Se caracteriza el nivel de texturado midiendo la reflectancia espectral de las muestras antes y después del tratamiento. El valor medio de la reflectancia espectral disminuye hasta el 6 %.

  10. Gravity Survey of the Rye Patch KGRA, Rye Patch, Nevada

    Science.gov (United States)

    Mcdonald, M. R.; Gosnold, W. D.

    2011-12-01

    The Rye Patch Known Geothermal Resource Area (KGRA) is located in Pershing County Nevada on the west side of the Humboldt Range and east of the Rye Patch Reservoir approximately 200 km northeast of Reno, Nevada. Previous studies include an earlier gravity survey, 3-D seismic reflection, vertical seismic profiling (VSP) on a single well, 3-D seismic imaging, and a report of the integrated seismic studies. Recently, Presco Energy conducted an aeromagnetic survey and is currently in the process of applying 2-D VSP methods to target exploration and production wells at the site. These studies have indicated that geothermal fluid flow primarily occurs along faults and fractures and that two potential aquifers include a sandstone/siltstone member of the Triassic Natchez Pass Formation and a karst zone that occurs at the interface between Mesozoic limestone and Tertiary volcanics. We hypothesized that addition of a high-resolution gravity survey would better define the locations, trends, lengths, and dip angles of faults and possible solution cavity features. The gravity survey encompassed an area of approximately 78 km2 (30 mi2) within the boundary of the KGRA along with portions of 8 sections directly to the west and 8 sections directly to the east. The survey included 203 stations that were spaced at 400 m intervals. The simple Bouguer anomaly patterns were coincident with elevation, and those patterns remained after terrain corrections were performed. To remove this signal, the data were further processed using wave-length (bandpass) filtering techniques. The results of the filtering and comparison with the recent aeromagnetic survey indicate that the location and trend of major fault systems can be identified using this technique. Dip angles can be inferred by the anomaly contour gradients. By further reductions in the bandpass window, other features such as possible karst solution channels may also be recognizable. Drilling or other geophysical methods such as a

  11. Perda de nutrientes via escoamento superficial no sistema plantio direto sob adubação mineral e orgânica Nutrient losses by surface runoff in no-till system soil under mineral and organic fertilization

    Directory of Open Access Journals (Sweden)

    Oromar João Bertol

    2011-11-01

    Full Text Available O sistema de plantio direto (SPD tem contribuído para melhorias nos solos agrícolas, dentre elas o aumento da concentração de nutrientes no solo. No entanto, tem se verificado que este aumento ocorre principalmente na camada superficial do solo, o que contribui para que ocorram perdas de nutrientes através de enxurradas, com danos econômicos e ambientais. Este trabalho avaliou a concentração total dos nutrientes potássio (K, cálcio (Ca, magnésio (Mg e cobre (Cu e do K nas formas solúvel e particulado, na enxurrada ocasionada por chuvas simuladas com diferentes intensidades aplicadas sobre solo manejado por cinco anos sob SPD, após aplicação superficial de adubo orgânico ou mineral. Os adubos não afetaram a concentração dos nutrientes estudados, exceto na condição da chuva mais intensa e solo sob adubação orgânica, onde a enxurrada apresentou maior concentração de K solúvel e K total. Independente do tipo de adubo utilizado, a chuva de maior intensidade ocasionou maior concentração de todos os nutrientes e formas estudados, evidenciando os benefícios econômicos e ambientais da adoção de práticas de contenção da enxurrada, mesmo em áreas cultivadas sob SPD.The no-tillage system, has contributed to improvements in agricultural soils, among them the like increases in nutrient concentrations.of mineral elements in soil. However, it has been found that this increase concentration occurs mainly in the first few centimeters of the superficial top layer and so risks of nutrient losses by runoff, and associated of the soil, which concurs for losses of mineral elements through of runoff, with economic and environmental damages, are high. This study evaluated the total concentration, in runoff, of mineral elements potassium (K, calcium (Ca, magnesium (Mg and copper (Cu in total form and the soluble and particulate concentration form of K, in runoff caused to simulated rainfall of different intensitiesy applied over soil

  12. Formulation optimization of arecoline patches.

    Science.gov (United States)

    Wu, Pao-Chu; Tsai, Pi-Ju; Lin, Shin-Chen; Huang, Yaw-Bin

    2014-01-01

    The response surface methodology (RSM) including polynomial equations has been used to design an optimal patch formulation with appropriate adhesion and flux. The patch formulations were composed of different polymers, including Eudragit RS 100 (ERS), Eudragit RL 100 (ERL) and polyvinylpyrrolidone K30 (PVP), plasticizers (PEG 400), and drug. In addition, using terpenes as enhancers could increase the flux of the drug. Menthol showed the highest enhancement effect on the flux of arecoline.

  13. Formulation Optimization of Arecoline Patches

    Directory of Open Access Journals (Sweden)

    Pao-Chu Wu

    2014-01-01

    Full Text Available The response surface methodology (RSM including polynomial equations has been used to design an optimal patch formulation with appropriate adhesion and flux. The patch formulations were composed of different polymers, including Eudragit RS 100 (ERS, Eudragit RL 100 (ERL and polyvinylpyrrolidone K30 (PVP, plasticizers (PEG 400, and drug. In addition, using terpenes as enhancers could increase the flux of the drug. Menthol showed the highest enhancement effect on the flux of arecoline.

  14. Preparation of Mucoadhesive Patches for Buccal Administration of ...

    African Journals Online (AJOL)

    Erah

    The development of bioadhesive buccal formulation for metoprolol ... a generation of many macromolecular drugs ... buccal drug delivery system should be ..... first order. Fig 2: Drug release profile of metoprolol succinate buccal patches made ...

  15. Automated multi-slice extracellular and patch-clamp experiments using the WinLTP data acquisition system with automated perfusion control

    Science.gov (United States)

    Anderson, William W.; Fitzjohn, Stephen M.; Collingridge, Graham L.

    2012-01-01

    WinLTP is a data acquisition program for studying long-term potentiation (LTP) and other aspects of synaptic function. Earlier versions of WinLTP (J. Neurosci. Methods, 162:346–356, 2007) provided automated electrical stimulation and data acquisition capable of running nearly an entire synaptic plasticity experiment, with the primary exception that perfusion solutions had to be changed manually. This automated stimulation and acquisition was done by using ‘Sweep’, ‘Loop’ and ‘Delay’ events to build scripts using the ‘Protocol Builder’. However, this did not allow automatic changing of many solutions while running multiple slice experiments, or solution changing when this had to be performed rapidly and with accurate timing during patch-clamp experiments. We report here the addition of automated perfusion control to WinLTP. First, perfusion change between sweeps is enabled by adding the ‘Perfuse’ event to Protocol Builder scripting and is used in slice experiments. Second, fast perfusion changes during as well as between sweeps is enabled by using the Perfuse event in the protocol scripts to control changes between sweeps, and also by changing digital or analog output during a sweep and is used for single cell single-line perfusion patch-clamp experiments. The addition of stepper control of tube placement allows dual- or triple-line perfusion patch-clamp experiments for up to 48 solutions. The ability to automate perfusion changes and fully integrate them with the already automated stimulation and data acquisition goes a long way toward complete automation of multi-slice extracellularly recorded and single cell patch-clamp experiments. PMID:22524994

  16. Patch photopatch test at Manipal

    Directory of Open Access Journals (Sweden)

    Panja Arindrajit

    1994-01-01

    Full Text Available Patch and photopatch testing was performed on 55 patients with history of photosensitivity using Scandanavian photo patch test antigens obtained from Chemotechnique Diagnostics AB Sweden. The commonest reactions were seen to perfume mix 4 (21.0%, PABA 3 (15.78%, promethazine hydrochloride 3 (15.78%, chlorpromazine hydrochloride 3 (15.78%, balsam of peru 2 (10.52%, usnic acid, hexachlorophane, musk ambrette and 6 methyl coumarin showed 1 positive reaction each (5.26% suggesting either phototoxicity or photo sensitization. Patch and photo patch test positive reaction suggesting allergic sensitisation was seen to balsam of peru 3 (23.0% perfume mix 3 (23.0% promethazine hydrochloride 2 (15.3% and PABA, 6 methyl coumarin, tribromosalicylanilide, atranorin and wood mix showed positive reaction in one case each (7.69%. We conclude that photoxic or photo allergic reaction is a problem in India and patch photo patch test should be performed in all cases of idiopathic light eruptions to rule out photo sensitisation and in cases where photo sensitivity of exogenous origin is suspected.

  17. Design and evaluation of an intravesical delivery system for superficial bladder cancer: preparation of gemcitabine HCl-loaded chitosan–thioglycolic acid nanoparticles and comparison of chitosan/poloxamer gels as carriers

    Directory of Open Access Journals (Sweden)

    Ay Şenyiğit Z

    2015-10-01

    Full Text Available Zeynep Ay Şenyiğit,1 Sinem Yaprak Karavana,1 Derya İlem-Özdemir,2 Çağrı Çalışkan,2 Claudia Waldner,3 Sait Şen,4 Andreas Bernkop-Schnürch,5 Esra Baloğlu1 1Faculty of Pharmacy, Department of Pharmaceutical Technology, Ege University, Bornova, İzmir, Turkey; 2Faculty of Pharmacy, Department of Radiopharmacy, Ege University, Bornova, İzmir, Turkey; 3ThioMatrix, Forschungs-Beratungs GmbH, Innsbruck, Austria; 4Faculty of Medicine, Department of Pathology, Ege University, Bornova, İzmir, Turkey; 5Institute of Pharmacy, Department of Pharmaceutical Technology, University of Innsbruck, Innsbruck, AustriaAbstract: This study aimed to develop an intravesical delivery system of gemcitabine HCl for superficial bladder cancer in order to provide a controlled release profile, to prolong the residence time, and to avoid drug elimination via urination. For this aim, bioadhesive nanoparticles were prepared with thiolated chitosan (chitosan–thioglycolic acid conjugate and were dispersed in bioadhesive chitosan gel or in an in situ gelling poloxamer formulation in order to improve intravesical residence time. In addition, nanoparticle-loaded gels were diluted with artificial urine to mimic in vivo conditions in the bladder and were characterized regarding changes in gel structure. The obtained results showed that chitosan-thioglycolic acid nanoparticles with a mean diameter of 174.5±3.762 nm and zeta potential of 32.100±0.575 mV were successfully developed via ionotropic gelation and that the encapsulation efficiency of gemcitabine HCl was nearly 20%. In vitro/ex vivo characterization studies demonstrated that both nanoparticles and nanoparticle-loaded chitosan and poloxamer gels might be alternative carriers for intravesical administration of gemcitabine HCl, prolonging its residence time in the bladder and hence improving treatment efficacy. However, when the gel formulations were diluted with artificial urine, poloxamer gels lost their in

  18. Design and evaluation of an intravesical delivery system for superficial bladder cancer: preparation of gemcitabine HCl-loaded chitosan-thioglycolic acid nanoparticles and comparison of chitosan/poloxamer gels as carriers.

    Science.gov (United States)

    Şenyiğit, Zeynep Ay; Karavana, Sinem Yaprak; İlem-Özdemir, Derya; Çalışkan, Çağrı; Waldner, Claudia; Şen, Sait; Bernkop-Schnürch, Andreas; Baloğlu, Esra

    2015-01-01

    This study aimed to develop an intravesical delivery system of gemcitabine HCl for superficial bladder cancer in order to provide a controlled release profile, to prolong the residence time, and to avoid drug elimination via urination. For this aim, bioadhesive nanoparticles were prepared with thiolated chitosan (chitosan-thioglycolic acid conjugate) and were dispersed in bioadhesive chitosan gel or in an in situ gelling poloxamer formulation in order to improve intravesical residence time. In addition, nanoparticle-loaded gels were diluted with artificial urine to mimic in vivo conditions in the bladder and were characterized regarding changes in gel structure. The obtained results showed that chitosanthioglycolic acid nanoparticles with a mean diameter of 174.5±3.762 nm and zeta potential of 32.100±0.575 mV were successfully developed via ionotropic gelation and that the encapsulation efficiency of gemcitabine HCl was nearly 20%. In vitro/ex vivo characterization studies demonstrated that both nanoparticles and nanoparticle-loaded chitosan and poloxamer gels might be alternative carriers for intravesical administration of gemcitabine HCl, prolonging its residence time in the bladder and hence improving treatment efficacy. However, when the gel formulations were diluted with artificial urine, poloxamer gels lost their in situ gelling properties at body temperature, which is in conflict with the aimed formulation property. Therefore, 2% chitosan gel formulation was found to be a more promising carrier system for intravesical administration of nanoparticles.

  19. Scanning electron microscopy of superficial white onychomycosis*

    Science.gov (United States)

    de Almeida Jr., Hiram Larangeira; Boabaid, Roberta Oliveira; Timm, Vitor; Silva, Ricardo Marques e; de Castro, Luis Antonio Suita

    2015-01-01

    Superficial white onychomycosis is characterized by opaque, friable, whitish superficial spots on the nail plate. We examined an affected halux nail of a 20-year-old male patient with scanning electron microscopy. The mycological examination isolated Trichophyton mentagrophytes. Abundant hyphae with the formation of arthrospores were found on the nail's surface, forming small fungal colonies. These findings showed the great capacity for dissemination of this form of onychomycosis. PMID:26560225

  20. Superficial Discussion Xuanhua Steel Supply System Voltage and Reactive Management Strategy%浅议宣钢供电系统电压无功管理策略

    Institute of Scientific and Technical Information of China (English)

    赵海峰

    2015-01-01

    从宣钢供电系统电压无功调节的实际情况出发,分析了电压质量和无功补偿之间的动态关系,并由此阐述了电压调节和无功功率平衡的方法,在此基础之上,总结了电压无功调节的策略,有助于提高宣钢供电系统电压调节水平。%From the actual situation Xuanhua Steel supply system voltage and reactive power regulation, we analyze the dynamic relationship between voltage and reactive power compensation between mass and thus elaborated voltage regulation and reactive power balanced approach on this basis, summed up the voltage and reactive power regulation policies to help improve Xuanhua Steel supply system voltage regulation level.

  1. 浅析电力计量自动化系统的综合应用%Superficial Analysis of Comprehensive Application of Electric Power Metering Automation System

    Institute of Scientific and Technical Information of China (English)

    任辉

    2015-01-01

    The power metering automation system is a new mode of electric power measurement, is a fusion of modern advanced technology of the integrated system can be timely to electricity demand for collection, analysis and processing, so as to improve the quality and efficiency of the electric power metering. Therefore, a simple analysis of the integrated application of electric power metering automation system is carried out.%电力计量自动化系统是一种新型的电力计量方式,是融合了现代各种先进技术的综合性系统,可及时对用电需求进行采集、分析和处理,从而提高电力计量的工作质量和效率。因此,主要对电力计量自动化系统的综合应用进行了简单分析。

  2. Superficial siderosis of the central nervous system induced by a single-episode of traumatic subarachnoid hemorrhage: a study using MRI-enhanced gradient echo T2 star-weighted angiography.

    Science.gov (United States)

    Zhao, Hongwei; Wang, Jin; Lu, Zhonglie; Wu, Qingjie; Lv, Haijuan; Liu, Hu; Gong, Xiangyang

    2015-01-01

    The purpose of this study was to examine whether a single episode of traumatic subarachnoid hemorrhage (tSAH) could cause superficial siderosis of the central nervous system (SS-CNS).This study was approved by the local ethics committee. Thirty-two patients with a history of a single episode of tSAH were enrolled in the study. An episode of tSAH was confirmed in patients based on a CT scan or a lumbar puncture, and a follow-up examination was conducted at least six weeks after the brain trauma. A follow-up MRI examination was performed, using enhanced gradient echo T2 star-weighted angiography (ESWAN) to detect hemosiderin deposition on the cortical surface. The extent to which hemosiderin deposition was associated with several clinical factors was investigated. Various degrees of hemosiderin deposition were detected in 31 of 32 (96.9%) single-episode tSAH patients. Analysis of contingency tables revealed an association between the regions of subarachnoid bleeding based on CT images and the regions of hemosiderin deposition based on ESWAN images (χ2 = 17.73, P<0.05). SS-CNS was determined to be a common consequence after a single episode of tSAH. The extent of hemosiderin deposition is closely correlated with the initial bleeding sites and bleeding volume.

  3. Superficial siderosis of the central nervous system induced by a single-episode of traumatic subarachnoid hemorrhage: a study using MRI-enhanced gradient echo T2 star-weighted angiography.

    Directory of Open Access Journals (Sweden)

    Hongwei Zhao

    Full Text Available The purpose of this study was to examine whether a single episode of traumatic subarachnoid hemorrhage (tSAH could cause superficial siderosis of the central nervous system (SS-CNS.This study was approved by the local ethics committee. Thirty-two patients with a history of a single episode of tSAH were enrolled in the study. An episode of tSAH was confirmed in patients based on a CT scan or a lumbar puncture, and a follow-up examination was conducted at least six weeks after the brain trauma. A follow-up MRI examination was performed, using enhanced gradient echo T2 star-weighted angiography (ESWAN to detect hemosiderin deposition on the cortical surface. The extent to which hemosiderin deposition was associated with several clinical factors was investigated. Various degrees of hemosiderin deposition were detected in 31 of 32 (96.9% single-episode tSAH patients. Analysis of contingency tables revealed an association between the regions of subarachnoid bleeding based on CT images and the regions of hemosiderin deposition based on ESWAN images (χ2 = 17.73, P<0.05. SS-CNS was determined to be a common consequence after a single episode of tSAH. The extent of hemosiderin deposition is closely correlated with the initial bleeding sites and bleeding volume.

  4. Constructing parametric triangular patches with boundary conditions

    Institute of Scientific and Technical Information of China (English)

    Hui Liu; Jun Ma; Fuhua Cheng

    2008-01-01

    The problem of constructing a parametric triangular patch to smoothly connect three surface patches is studied. Usually, these surface patches are defined on different parameter spaces. Therefore, it is necessary to define interpolation conditions, with values from the given surface patches, on the boundary of the triangular patch that can ensure smooth transition between different parameter spaces. In this paper we present a new method to define boundary conditions. Boundary conditions defined by the new method have the same parameter space if the three given surface patches can be converted into the same form through affine transformation. Consequently, any of the classic methods for constructing functional triangular patches can be used directly to construct a parametric triangular patch to connect given surface patches with G continuity. The resulting parametric triangular patch preserves precision of the applied classic method.

  5. Modular assembly of thick multifunctional cardiac patches

    Science.gov (United States)

    Fleischer, Sharon; Shapira, Assaf; Feiner, Ron; Dvir, Tal

    2017-01-01

    In cardiac tissue engineering cells are seeded within porous biomaterial scaffolds to create functional cardiac patches. Here, we report on a bottom-up approach to assemble a modular tissue consisting of multiple layers with distinct structures and functions. Albumin electrospun fiber scaffolds were laser-patterned to create microgrooves for engineering aligned cardiac tissues exhibiting anisotropic electrical signal propagation. Microchannels were patterned within the scaffolds and seeded with endothelial cells to form closed lumens. Moreover, cage-like structures were patterned within the scaffolds and accommodated poly(lactic-co-glycolic acid) (PLGA) microparticulate systems that controlled the release of VEGF, which promotes vascularization, or dexamethasone, an anti-inflammatory agent. The structure, morphology, and function of each layer were characterized, and the tissue layers were grown separately in their optimal conditions. Before transplantation the tissue and microparticulate layers were integrated by an ECM-based biological glue to form thick 3D cardiac patches. Finally, the patches were transplanted in rats, and their vascularization was assessed. Because of the simple modularity of this approach, we believe that it could be used in the future to assemble other multicellular, thick, 3D, functional tissues. PMID:28167795

  6. A new method in the management of skin neoplasm using a flexible radioactive patch

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jong Doo; Park, Sang Gun; Lee, Min Geol [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Kim, Gwi Eon; Chung, Yae Lee [Yonsei University College of Medicine, Seoul (Korea, Republic of); Kim, Eun Hee [Korea Cancer Center Hospital, Seoul (Korea, Republic of); Park, Kyung Bae [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    2005-07-01

    We have developed a flexible radioactive polyurethane patch incorporating {beta}-emitting radionuclide (166Ho) to treat malignant skin lesions. We covered the tumor surface (n=133) with the radioactive patch for 33.58 {+-} 5.33 minutes. Radiation dose delivered was 35 Gy for Bowen's disease (n=78), Kaposi sarcoma (n=25), actinic keratosis (n=5), and 50 Gy for BCC (n=17) and squamous carcinoma (n=8). Complete response was observed in 91.7% after the first therapeutic trial, 96.2% after 2nd and 97.7% after 4th trial with excellent cosmetic outcome for 31.15{+-}13.88 months of follow-up. Radioactive patch therapy is effective for superficial skin cancers that are impractical for surgery.

  7. Unusual edge effect in patch testing with silver nitrate.

    Science.gov (United States)

    Iliev, D; Elsner, P

    1998-03-01

    Silver nitrate is a widely used substance and has been applied topically for cauterizing bleeding and healing wounds. In the past it has even been used to mark patch test sites, when no one knew that the substance itself might be a sensitizer. However, there are also toxic reactions to that substance. We report a case in which a positive "edge effect" at the periphery of the patch test site could be shown. It can be explained by the unequal distribution of patch test solutions in the different patch test systems with a concentration at the rim. Distinguishing between allergic and toxic reactions may be difficult when an edge effect occurs. Therefore, in certain rare cases a biopsy or a lymphocyte transformation test might be of help.

  8. Reinforcement of a plate weakened by multiple holes with several patches for different types of a plate-patch attachment

    CERN Document Server

    Zemlyanova, A Y

    2012-01-01

    The most general situation of the reinforcement of a plate with multiple holes by several patches is considered. There is no restriction on the number and the location of the patches. Two types of the patch attachment are considered: only along the boundary of the patch or both along the boundary of the patch and the boundaries of the holes which this patch covers. The unattached boundaries of the holes may be loaded with given in-plane stresses. The mechanical problem is reduced to the system of singular integral equations which can be further reduced to the system of Fredholm equations. A new numerical procedure for the solution of the system of singular integral equations is proposed in this paper. It can be observed that this procedure provides a noticeable improvement from the one presented in Zemlyanova \\cite{Zem2007}, Zemlyanova and Silvestrov \\cite{ZemSil2007}, \\cite{ZemSil2009} and allows to achieve a significantly better numerical convergence with less computational effort.

  9. Improved Gain Microstrip Patch Antenna

    Science.gov (United States)

    2015-08-06

    same as one half wavelength, λ, of a design frequency for reception or transmission by the antenna 10. Patch 16 can be joined to a coaxial feed 18. A...expressed in the appended claims. [0024] The foregoing description of the preferred embodiments of the invention has been presented for purposes of

  10. 瑞敏系列和TURE TEST系列斑贴试剂检测结果比较%Comparison of Patch Test Results Useing IQ Chamber System and TURE TEST

    Institute of Scientific and Technical Information of China (English)

    曹晓佳; 张理涛

    2012-01-01

    目的 分析瑞敏系列(R)和TURE TEST系列(T)斑贴试剂检测结果及一致性.方法 分别用这两个系列斑贴试剂检测196例慢性湿疹和接触性皮炎患者,对其检测结果进行比较.结果 瑞敏系列和TURE TEST系列斑贴试剂对各变应原检测阳性率不完全相同,它们检测常见变应原种类均与国内已有报道类似;两个系列中相同的16种变应原的检测反应强度一致性较好,检测的阳性率差异无统计学意义(P>0.05).结论 两个系列斑贴试剂的一致性较好,临床上可根据患者情况选择应用.%Objective To study the patch test reactions and the concordance of IQ chamber system (R) and TRUE Test (T). Methods Two different series patch test reagents were performed to detect 196 patients with chronic eczema and contact dermatitis, then the results were compared. Results The positive rates of every allergen were not completely the same,the most common allergens known from two series reagents were similar with the past reported of inland. The strength of allergic reaction of the same 16 allergens of two series reagents had good consistence and the positive rates of R and T were statistically insignificance. Conclusion This two different patch test series exhibited a high level of consistence, and doctors could choose suitable series according to the conditions of patients in clinic.

  11. Dosimetric comparison between a planning system and Radiochromic-EBT2 films in surface brachytherapy treatments of high rate; Comparacion dosimetrica entre un sistema de planificacion y peliculas radiocromicas EBT2 en tratamientos de braquiterapia superficial de alta tasa

    Energy Technology Data Exchange (ETDEWEB)

    Gutierrez Ramos, S. M.; Carrasco Herrera, M. a.; Vicent, D.; Rodriguez, C.; Herrador, M.

    2013-07-01

    The objective of this work is to study a situation in which, the accuracy of the calculation of the planner may be limited, superficial brachytherapy treatment. It has relative to the dose obtained with the planner with that obtained with film radiochromic EBT2. (Author)

  12. Covalent modification of pericardial patches for sustained rapamycin delivery inhibits venous neointimal hyperplasia

    Science.gov (United States)

    Bai, Hualong; Lee, Jung Seok; Chen, Elizabeth; Wang, Mo; Xing, Ying; Fahmy, Tarek M.; Dardik, Alan

    2017-01-01

    Prosthetic grafts and patches are commonly used in cardiovascular surgery, however neointimal hyperplasia remains a significant concern, especially under low flow conditions. We hypothesized that delivery of rapamycin from nanoparticles (NP) covalently attached to patches allows sustained site-specific delivery of therapeutic agents targeted to inhibit localized neointimal hyperplasia. NP were covalently linked to pericardial patches using EDC/NHS chemistry and could deliver at least 360 ng rapamycin per patch without detectable rapamycin in serum; nanoparticles were detectable in the liver, kidney and spleen but no other sites within 24 hours. In a rat venous patch angioplasty model, control patches developed robust neointimal hyperplasia on the patch luminal surface characterized by Eph-B4-positive endothelium and underlying SMC and infiltrating cells such as macrophages and leukocytes. Patches delivering rapamycin developed less neointimal hyperplasia, less smooth muscle cell proliferation, and had fewer infiltrating cells but retained endothelialization. NP covalently linked to pericardial patches are a novel composite delivery system that allows sustained site-specific delivery of therapeutics; NP delivering rapamycin inhibit patch neointimal hyperplasia. NP linked to patches may represent a next generation of tissue engineered cardiovascular implants.

  13. Patching the Exchange-Correlation Potential in Density Functional Theory.

    Science.gov (United States)

    Huang, Chen

    2016-05-10

    A method for directly patching exchange-correlation (XC) potentials in materials is derived. The electron density of a system is partitioned into subsystem densities by dividing its Kohn-Sham (KS) potential among the subsystems. Inside each subsystem, its projected KS potential is required to become the total system's KS potential. This requirement, together with the nearsightedness principle of electronic matters, ensures that the electronic structures inside subsystems can be good approximations to the total system's electronic structure. The nearsightedness principle also ensures that subsystem densities could be well localized in their regions, making it possible to use high-level methods to invert the XC potentials for subsystem densities. Two XC patching methods are developed. In the local XC patching method, the total system's XC potential is improved in the cluster region. We show that the coupling between a cluster and its environment is important for achieving a fast convergence of the electronic structure in the cluster region. In the global XC patching method, we discuss how to patch the subsystem XC potentials to construct the XC potential in the total system, aiming to scale up high-level quantum mechanics simulations of materials. Proof-of-principle examples are given.

  14. Habitat patch size and isolation as predictors of occupancy and number of argyrodine spider kleptoparasites in Nephila webs

    Science.gov (United States)

    Agnarsson, Ingi

    2011-02-01

    How fully a suitable habitat patch is utilized by organisms depends crucially on patch size and isolation. Testing this interplay is made difficult in many systems by the arbitrariness of defining a "habitat patch", measuring its boarders, and relatively low detection probability of the inhabitants. Spider webs as habitat patches for obligate web kleptoparasites are free from these problems. Each individual web is a highly discrete and readily measured habitat patch, and the detection probability of argyrodine spider kleptoparasites is very nearly 1. Hence, spider webs emerge as simple systems for ecological models such as patch occupancy and metapopulation biology. Recently, I showed that the distribution of kleptoparasites among host webs relates both to web (patch) size as well as patch connectivity. Here, I test the relative importance of patch size versus isolation in explaining patch occupancy and abundance of inhabitants. I find that (1) web size is the better predictor of patch occupancy and abundance. (2) Web size is overall positively correlated with abundance, but predicts it most precisely among interconnected webs and not at all among the most isolated webs. Hence, patch occupancy and inhabitant abundance is explained by a rather complex interplay between patch size and isolation.

  15. Superficial Urothelial Cancer in the Prostatic Urethra

    Directory of Open Access Journals (Sweden)

    Ziya Kirkali

    2006-01-01

    Full Text Available Transitional cell carcinoma (TCC is a multifocal disease of the urinary tract that can also involve the prostatic urethra (PU. The exact incidence of superficial involvement of the PU in patients with bladder TCC is not well known. Bladder TCC may involve the prostate in 12—40% of the patients and the degree of involvement can include urethral mucosa, ducts, acini, and stroma of the gland, which has been shown to affect the outcome. Risk factors for superficial urothelial cancer in the PU are high-grade, multifocal bladder TCC and presence of carcinoma in situ (CIS in the bladder. While visible tumors are easy to detect and resect, controversy still exists regarding the optimal technique to identify prostatic involvement by TCC. Prostatic urethral sampling by a transurethral resection biopsy or a cold-cup biopsy, particularly in the high-risk group of bladder cancer patients, has been recommended for detecting prostatic urethral involvement. Management of superficial prostatic involvement by TCC is also unclear. Currently, there is increasing recognition of the value of conservative treatment options with intravesical agents when there is superficial involvement of the PU. Particularly, intravesical bacillus Calmette-Guèrin (BCG seems to be an effective treatment alternative in the management of superficial involvement of the PU by TCC. Close follow-up by cystoscopy and PU biopsy at 3-month intervals, particularly in intermediate and high-risk patients who respond to intravesical therapy and in whom cystectomy is appropriate, is recommended in order to detect persistent tumor, recurrences, or progression.

  16. Superficial urothelial cancer in the prostatic urethra.

    Science.gov (United States)

    Kirkali, Ziya; Canda, A Erdem

    2006-02-28

    Transitional cell carcinoma (TCC) is a multifocal disease of the urinary tract that can also involve the prostatic urethra (PU). The exact incidence of superficial involvement of the PU in patients with bladder TCC is not well known. Bladder TCC may involve the prostate in 12-40% of the patients and the degree of involvement can include urethral mucosa, ducts, acini, and stroma of the gland, which has been shown to affect the outcome. Risk factors for superficial urothelial cancer in the PU are high-grade, multifocal bladder TCC and presence of carcinoma in situ (CIS) in the bladder. While visible tumors are easy to detect and resect, controversy still exists regarding the optimal technique to identify prostatic involvement by TCC. Prostatic urethral sampling by a transurethral resection biopsy or a cold-cup biopsy, particularly in the high-risk group of bladder cancer patients, has been recommended for detecting prostatic urethral involvement. Management of superficial prostatic involvement by TCC is also unclear. Currently, there is increasing recognition of the value of conservative treatment options with intravesical agents when there is superficial involvement of the PU. Particularly, intravesical bacillus Calmette-Guèrin (BCG) seems to be an effective treatment alternative in the management of superficial involvement of the PU by TCC. Close follow-up by cystoscopy and PU biopsy at 3-month intervals, particularly in intermediate and high-risk patients who respond to intravesical therapy and in whom cystectomy is appropriate, is recommended in order to detect persistent tumor, recurrences, or progression.

  17. Patch stage of mycosis fungoides

    Directory of Open Access Journals (Sweden)

    Mavarkar Laxman

    2001-01-01

    Full Text Available Parapsoriasis is aeon troversial topic. There are many studies regarding the relationship of parapsoriasis to lymphoma but no correlation between histology and clinical appearance. Parapsoriasis satisfies histologic criteria for mycosis fungoides and therefore it should be considered as patch stage of mycosis fungoides. A 30-year-old man presented with scaly skin lesions over the trunk since 4 years. Routine blood and urine investigations were normal. Skin biopsy from the lesion revealed atypical lymphocytes within the epidermis without spongiosis.

  18. Palmar herald patch in pityriasis rosea.

    Science.gov (United States)

    Polat, Mualla; Yildirim, Yasemin; Makara, Anil

    2012-08-01

    Pityriasis rosea is an acute self-limited inflammatory disorder of the skin. The initial clinical features of typical cases are the appearance of a herald patch. The herald patch is commonly located on the thigh, upper arm, trunk or neck; rarely the patch may be on the face, scalp or penis. There are no reports of a palmar herald patch in pityriasis rosea. In this article we present a 14-year-old male patient who had a palmar herald patch with truncal lesions of pityriasis rosea. © 2012 The Authors. Australasian Journal of Dermatology © 2012 The Australasian College of Dermatologists.

  19. Patching. Restitching business portfolios in dynamic markets.

    Science.gov (United States)

    Eisenhardt, K M; Brown, S L

    1999-01-01

    In turbulent markets, businesses and opportunities are constantly falling out of alignment. New technologies and emerging markets create fresh opportunities. Converging markets produce more. And of course, some markets fade. In this landscape of continuous flux, it's more important to build corporate-level strategic processes that enable dynamic repositioning than it is to build any particular defensible position. That's why smart corporate strategists use patching, a process of mapping and remapping business units to create a shifting mix of highly focused, tightly aligned businesses that can respond to changing market opportunities. Patching is not just another name for reorganizing; patchers have a distinctive mindset. Traditional managers see structure as stable; patching managers believe structure is inherently temporary. Traditional managers set corporate strategy first, but patching managers keep the organization focused on the right set of business opportunities and let strategy emerge from individual businesses. Although the focus of patching is flexibility, the process itself follows a pattern. Patching changes are usually small in scale and made frequently. Patching should be done quickly; the emphasis is on getting the patch about right and fixing problems later. Patches should have a test drive before they're formalized but then be tightly scripted after they've been announced. And patching won't work without the right infrastructure: modular business units, fine-grained and complete unit-level metrics, and companywide compensation parity. The authors illustrate how patching works and point out some common stumbling blocks.

  20. Formaldehyde concentration in diagnostic patch testing

    DEFF Research Database (Denmark)

    Trattner, A; Johansen, J D; Menné, T

    1998-01-01

    Exposure to formaldehyde is common from both consumer products and industry. The reliability of the patch test is essential for the diagnosis of formaldehyde allergy as it is difficult to suspect from the patient's history. The recommended formaldehyde patch test concentration has been reduced over......% in consecutively patch-tested patients, with respect to frequency of positive patch test reactions, strength of patch test reactions to different formaldehyde test concentrations, irritancy and relevance. The study included 3734 consecutively patch tested patients. 121 gave a positive reaction to 1% and/or 2...... gave few additional positive cases compared to D 3/4. Problems related to relevance are discussed. Based on present knowledge, a 1% patch test concentration for formaldehyde is recommended....

  1. Segmentation and labeling of the ventricular system in normal pressure hydrocephalus using patch-based tissue classification and multi-atlas labeling

    Science.gov (United States)

    Ellingsen, Lotta M.; Roy, Snehashis; Carass, Aaron; Blitz, Ari M.; Pham, Dzung L.; Prince, Jerry L.

    2016-03-01

    Normal pressure hydrocephalus (NPH) affects older adults and is thought to be caused by obstruction of the normal flow of cerebrospinal fluid (CSF). NPH typically presents with cognitive impairment, gait dysfunction, and urinary incontinence, and may account for more than five percent of all cases of dementia. Unlike most other causes of dementia, NPH can potentially be treated and the neurological dysfunction reversed by shunt surgery or endoscopic third ventriculostomy (ETV), which drain excess CSF. However, a major diagnostic challenge remains to robustly identify shunt-responsive NPH patients from patients with enlarged ventricles due to other neurodegenerative diseases. Currently, radiologists grade the severity of NPH by detailed examination and measurement of the ventricles based on stacks of 2D magnetic resonance images (MRIs). Here we propose a new method to automatically segment and label different compartments of the ventricles in NPH patients from MRIs. While this task has been achieved in healthy subjects, the ventricles in NPH are both enlarged and deformed, causing current algorithms to fail. Here we combine a patch-based tissue classification method with a registration-based multi-atlas labeling method to generate a novel algorithm that labels the lateral, third, and fourth ventricles in subjects with ventriculomegaly. The method is also applicable to other neurodegenerative diseases such as Alzheimer's disease; a condition considered in the differential diagnosis of NPH. Comparison with state of the art segmentation techniques demonstrate substantial improvements in labeling the enlarged ventricles, indicating that this strategy may be a viable option for the diagnosis and characterization of NPH.

  2. Robotic patch-stabilizer using wire driven mechanism for minimally invasive fetal surgery.

    Science.gov (United States)

    Zhang, Bo; Kobayashi, Yo; Chiba, Toshio; Fujie, Masakatsu G

    2009-01-01

    The clinical target of this study is intrauterine patch coverage of fetal myelomeningocele. We propose a new surgical robotic system for intrauterine fetal surgery with patch-stabilizer and laser manipulator. The target disease of the fetal surgery is spina bifida or myelomeningocele, which is incomplete closure in the spinal column and one of the common fetal diseases. In the fetal surgery, the collagen patch is supposed to be stabilized onto the fragile fetal tissue during the laser fixation process. In this study, a prototype of the patch-stabilizer using wire driven mechanism has been developed for precise force control on the patch without damaging fetal tissue. The diameter of the patch-stabilizer's shaft is 2.4 mm. The patch-stabilizer including one ball joint and wire driven mechanism is able to bend through 40 degrees. The stabilizing part holds collagen patch with diamond shape mechanism using wire driven. In this paper, we showed that the patch-stabilizer is developed with the stabilizing force control using the tension control of wires. Results of the experiment showed that the tension of driven wires was controlled at 0.3 N to stabilize the collagen patch onto the lesion surface without the damages of fetal tissues and the influence by the amnion liquid.

  3. Within and Among Patch Variability in Patterns of Insect Herbivory Across a Fragmented Forest Landscape.

    Directory of Open Access Journals (Sweden)

    Dorothy Y Maguire

    Full Text Available Fragmentation changes the spatial patterns of landscapes in ways that can alter the flow of materials and species; however, our understanding of the consequences of this fragmentation and flow alteration for ecosystem processes and ecosystem services remains limited. As an ecological process that affects many ecosystem services and is sensitive to fragmentation, insect herbivory is a good model system for exploring the role of fragmentation, and the resulting spatial patterns of landscapes, in the provision of ecosystem services. To refine our knowledge of how changes in landscape pattern affect insect herbivory, we quantified the combined influence of among patch (patch area and patch connectivity and within patch (location within patch; canopy, edge, interior factors on amounts of insect herbivory in a fragmented forest landscape. We measured herbivory in 20 forest patches of differing size and connectivity in southern Quebec (Canada. Within each patch, herbivory was quantified at the interior, edge, and canopy of sugar maple trees during the spring and summer of 2011 and 2012. Results show that connectivity affects herbivory differently depending on the location within the patch (edge, interior, canopy, an effect that would have gone unnoticed if samples were pooled across locations. These results suggest considering structure at both the patch and within patch scales may help to elucidate patterns when studying the effects of fragmentation on ecosystem processes, with implications for the services they support.

  4. Patched2 modulates tumorigenesis in patched1 heterozygous mice.

    Science.gov (United States)

    Lee, Youngsoo; Miller, Heather L; Russell, Helen R; Boyd, Kelli; Curran, Tom; McKinnon, Peter J

    2006-07-15

    The sonic hedgehog (SHH) receptor Patched 1 (Ptch1) is critical for embryonic development, and its loss is linked to tumorigenesis. Germ line inactivation of one copy of Ptch1 predisposes to basal cell carcinoma and medulloblastoma in mouse and man. In many cases, medulloblastoma arising from perturbations of Ptch1 function leads to a concomitant up-regulation of a highly similar gene, Patched2 (Ptch2). As increased expression of Ptch2 is associated with medulloblastoma and other tumors, we investigated the role of Ptch2 in tumor suppression by generating Ptch2-deficient mice. In striking contrast to Ptch1-/- mice, Ptch2-/- animals were born alive and showed no obvious defects and were not cancer prone. However, loss of Ptch2 markedly affected tumor formation in combination with Ptch1 haploinsufficiency. Ptch1+/-Ptch2-/- and Ptch1+/-Ptch2+/- animals showed a higher incidence of tumors and a broader spectrum of tumor types compared with Ptch1+/- animals. Therefore, Ptch2 modulates tumorigenesis associated with Ptch1 haploinsufficiency.

  5. What factors control superficial lava dome explosivity?

    Science.gov (United States)

    Boudon, Georges; Balcone-Boissard, Hélène; Villemant, Benoît; Morgan, Daniel J.

    2015-09-01

    Dome-forming eruption is a frequent eruptive style and a major hazard on numerous volcanoes worldwide. Lava domes are built by slow extrusion of degassed, viscous magma and may be destroyed by gravitational collapse or explosion. The triggering of lava dome explosions is poorly understood: here we propose a new model of superficial lava-dome explosivity based upon a textural and geochemical study (vesicularity, microcrystallinity, cristobalite distribution, residual water contents, crystal transit times) of clasts produced by key eruptions. Superficial explosion of a growing lava dome may be promoted through porosity reduction caused by both vesicle flattening due to gas escape and syn-eruptive cristobalite precipitation. Both processes generate an impermeable and rigid carapace allowing overpressurisation of the inner parts of the lava dome by the rapid input of vesiculated magma batches. The relative thickness of the cristobalite-rich carapace is an inverse function of the external lava dome surface area. Explosive activity is thus more likely to occur at the onset of lava dome extrusion, in agreement with observations, as the likelihood of superficial lava dome explosions depends inversely on lava dome volume. This new result is of interest for the whole volcanological community and for risk management.

  6. HISTOPATHOLOGY OF MARGINAL SUPERFICIAL PERIODONTIUM AT MENOPAUSE

    Directory of Open Access Journals (Sweden)

    A. Georgescu

    2012-03-01

    Full Text Available Premises: Sexual hormones may affect the general health condition of women, as early as puberty, continuing during pregnancy and also after menopause. Variations of the hormonal levels may cause different – either local or general – pathological modifications. Sexual hormones may also affect periodontal status, favourizing gingival inflammations and reducing periodontal resistance to the action of the bacterial plaque. Scope: Establishment of the correlations between the debut or the manifestation of menopause and the modifications produced in the superficial periodontium. Materials and method: Clinical and paraclinical investigations were performed on female patients with ages between 45 and 66 years, involving macroscopic, microscopic and radiological recording of the aspect of the superificial periodontium (gingiva. Results: Analysis of the histological sections evidenced atrophic and involutive modifications in the marginal superficial periodontium of female patients at menopause. Conclusions: Sexual hormones intervene in the histological equilibrium of the marginal superficial periodontium, influencing the periodontal health status, which explains the correlation between the subjective symptomatology specific to menopause and the histopatological aspect at epithelial level.

  7. 面神经颞、颧、颊支与SMAS关系的解剖学研究%Anatomic study of the branche of the facial nerve and its relationship with superficial musculoaponeurotic system in rhytidectomy

    Institute of Scientific and Technical Information of China (English)

    刘志勇; 丁自海

    2011-01-01

    Objective To clear the movement of rami temporales, zygomatic branches, buccal branches and the relationship between facial superficial musculoaponeurotic system (SMAS) with them in order to provide important morphological data for mid facial thytidectomy. Methods 10 (20 sides) adult's pate samples were dissected observed and measured step by step. The results and data were drawn in the coordinate system with the X-aix which was in the plane the cut trace of paropia and tragus, and the origin was the cut point in tragus. Results ① Rami temporales were more 3 rami forma than other forms.Most of branches come from the front edge of parotid gland, the goacross the 1/3 border around zygomatic arch and move in the adipose tissue hyp-SMAS. ②There were more 2 rami forma than others in the zygomatic hranches. which come through the upper or front of edge of parotid gland and move in the masseteric fascia.The upper part was in the shallow position.It runs into the muscle from the outer edge of orbicularis oculi in the 1/3 surface of the zygomaticus major; The position of the lower part was more deaper,which can go deep into zygomaticus major. ③Zygomatic branches were mainly 3 rami forma. To fix their positions was difficult for they always move differently , form nerve plexus and walk at the surface of buccal fat pad or inside.Conclusion It's quite safe to doing the SMAS seperation in the parotid gland area with all branches moving in parotid glandular substance of prostate. Dull SMAS seperation should he used to avoid facial nerve injary at the surface of masseteric fascia and buccal fat pad. The seperation should be done under the surface of zygomaticus major and strittly limited below 0.5 cm of the surface (2/3 part of the surface ). Temporal region is safe when the seperation of fascia temporalis superficialis is done behide the hairline .but is should be tumed to the superficial seperation across the hairline. The surface and the upper part of zygomatic arch are

  8. Anatomical Connections of the Functionally Defined "Face Patches" in the Macaque Monkey.

    Science.gov (United States)

    Grimaldi, Piercesare; Saleem, Kadharbatcha S; Tsao, Doris

    2016-06-15

    The neural circuits underlying face recognition provide a model for understanding visual object representation, social cognition, and hierarchical information processing. A fundamental piece of information lacking to date is the detailed anatomical connections of the face patches. Here, we injected retrograde tracers into four different face patches (PL, ML, AL, AM) to characterize their anatomical connectivity. We found that the patches are strongly and specifically connected to each other, and individual patches receive inputs from extrastriate cortex, the medial temporal lobe, and three subcortical structures (the pulvinar, claustrum, and amygdala). Inputs from prefrontal cortex were surprisingly weak. Patches were densely interconnected to one another in both feedforward and feedback directions, inconsistent with a serial hierarchy. These results provide the first direct anatomical evidence that the face patches constitute a highly specialized system and suggest that subcortical regions may play a vital role in routing face-related information to subsequent processing stages.

  9. Enhanced patch test of finite element methods

    Institute of Scientific and Technical Information of China (English)

    CHEN; Wanji

    2006-01-01

    Theoretically, the constant stress patch test is not rigorous. Also, either the patch test of non-zero constant shear for Mindlin plate problem or non-zero strain gradient curvature of the microstructures cannot be performed. To improve the theory of the patch test, in this paper, based on the variational principle with relaxed continuity requirement of nonconforming element for homogeneous differential equations, the author proposed the individual element condition for passing the patch test and the convergence condition of the element: besides passing the patch test, the element function should include the rigid body modes and constant strain modes and satisfy the weak continuity condition, and no extra zero energy modes occur. Moreover, the author further established a variational principle with relaxed continuity requirement of nonconforming element for inhomogeneous differential equations, the enhanced patch test condition and the individual element condition. To assure the convergence of the element that should pass the enhanced patch test, the element function should include the rigid body modes and non-zero strain modes which satisfied the equilibrium equations, and no spurious zero energy modes occur and should satisfy new weak continuity condition. The theory of the enhanced patch test proposed in this paper can be applied to both homogeneous and inhomogeneous differential equations. Based on this theory, the patch test of the non-zero constant shear stress for Mindlin plate and the C0-1 patch test of the non-zero constant curvature for the couple stress/strain gradient theory were established.

  10. A DOUBLE E SHAPED MICROSTRIP PATCH ANTENNA FOR MULTIBAND APPLICATIONS

    Directory of Open Access Journals (Sweden)

    Pristin K Mathew

    2014-06-01

    Full Text Available This paper presents a dual band Compact double E shaped Microstrip Patch antenna with enhanced gain for Worldwide Interoperability for Microwave Access (WI-MAX, Universal Mobile Telecommunication Systems (UMTS and Satellite applications. The modified E shaped patch antenna is designed using CADFEKO and the results of return loss, Voltage Standing Wave Ratio (VSWR, gain of the proposed antenna are compared with a conventional E shaped patch antenna. The results show that the double E shaped wideband patch antenna has an impedance bandwidth of 10.7 % with a return loss of -13.6dB, -12.4 dB, -12.1dB and -14.2dB at resonant frequencies of 1.96 GHz, 3.62 GHz, 5.76 GHz and 6.82 GHz, whereas a conventional E shaped patch antenna operates at 2.5 GHz, 3.4 GHz and 5.5 GHz with a return loss of -16 dB each and impedance bandwidth of 10.6 %. Both the antennas uses Coaxial Probe feeding technique and Flame Retardant 4 (FR-4 as the substrate material with a thickness of 2.87 mm. A parametric study has been done so as to understand the effect of each parameter to obtain a better performance and optimised results.

  11. Modeling of endovascular patch welding using the computer program LATIS

    Energy Technology Data Exchange (ETDEWEB)

    Glinsky, M.E.; London, R.A.; Zimmerman, G.B. [Lawrence Livermore National Lab., CA (United States); Jacques, S.L. [Univ. of Texas, Houston, TX (United States). M. D. Anderson Cancer Center

    1995-03-01

    A new computer program, LATIS, being developed at Lawrence Livermore National Laboratory is used to study the effect of pulsed laser irradiation on endovascular patch welding. Various physical and biophysical effects are included in these simulations: laser light scattering and absorption, tissue heating and heat conduction, vascular cooling, and tissue thermal damage. The geometry of a patch being held against the inner vessel wall (500 {mu}m inner diameter) by a balloon is considered. The system is exposed to light pulsed from an optical fiber inside the balloon. A minimum in the depth of damage into the vessel wall is found. The minimum damage zone is about the thickness of the patch material that is heated by the laser. The more ordered the tissue the thinner the minimum zone of damage. The pulse length which minimizes the zone of damage is found to be the time for energy to diffuse across the layer. The delay time between the pulses is determined by the time for the heated layer to cool down. An optimal pulse length exists which minimizes the total time needed to weld the patch to the wall while keeping the thickness of the damaged tissue to less than 100 {mu}m. For the case that is considered, a patch dyed with light absorbing ICG on the side next to the vessel (thickness of the dyed layer is 60 {mu}m), the best protocol is found to be 65-200 ms pulses applied over 2 min.

  12. Transparent biocompatible sensor patches for touch sensitive prosthetic limbs

    KAUST Repository

    Nag, Anindya

    2016-12-26

    The paper presents the fabrication of transparent, flexible sensor patches developed using a casting technique with polydimethylsiloxane (PDMS) as substrate and a nanocomposite of carbon nanotubes (CNTs) and PDMS as interdigital electrodes. The electrodes act as strain sensitive capacitor. The prototypes were used as touch sensitive sensors attached to the limbs. Experiments results show the sensitivity of the patches towards tactile sensing. The results are very promising and can play a key role in the development of a cost efficient sensing system attached to prosthetic limbs.

  13. Species presence frequency and diversity in different patch types along an altitudinal gradient: Larix chinensis Beissn in Qinling Mountains (China

    Directory of Open Access Journals (Sweden)

    Minyi Huang

    2016-03-01

    Full Text Available Forest communities are mosaic systems composed of patches classified into four different developmental patch types: gap patch (G, building patch (B, mature patch (M and degenerate patch (D. To study the mechanisms maintaining diversity in subalpine coniferous forests, species presence frequency and diversity in the four distinct patch types (G, B, M and D of Larix chinensis conifer forests at three altitudinal gradients in the Qinling Mountains were analyzed. Our results were as follows: (1 Different species (or functional groups had distinct presence frequencies in the four different patch types along the altitudinal gradient; (2 Some species or functional groups (species groups sharing similar traits and responses to the environment only occurred in some specific patches. For seed dispersal, species using wind mainly occurred in G and D, while species using small animals mainly occurred in B and M; (3 Species composition of adjacent patch types was more similar than non-adjacent patch types, based on the lower β diversity index of the former; (4 The maximum numbers of species and two diversity indices (D′ and H′ were found in the middle altitudes. Various gap-forming processes and dispersal limitation may be the two major mechanisms determining species diversity in Larix chinensis coniferous forests at the patch scale.

  14. Compliance and patching and atropine amblyopia treatments.

    Science.gov (United States)

    Wang, Jingyun

    2015-09-01

    In the past 20 years, there has been a great advancement in knowledge pertaining to compliance with amblyopia treatments. The occlusion dose monitor introduced quantitative monitoring methods in patching, which sparked our initial understanding of the dose-response relationship for patching amblyopia treatment. This review focuses on current compliance knowledge and the impact it has on patching and atropine amblyopia treatment. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Multi-Mode Broadband Patch Antenna

    Science.gov (United States)

    Romanofsky, Robert R. (Inventor)

    2001-01-01

    A multi-mode broad band patch antenna is provided that allows for the same aperture to be used at independent frequencies such as reception at 19 GHz and transmission at 29 GHz. Furthermore, the multi-mode broadband patch antenna provides a ferroelectric film that allows for tuning capability of the multi-mode broadband patch antenna over a relatively large tuning range. The alternative use of a semiconductor substrate permits reduced control voltages since the semiconductor functions as a counter electrode.

  16. RF MEMS reconfigurable triangular patch antenna.

    Energy Technology Data Exchange (ETDEWEB)

    Christodoulou, Christos George (The University of New Mexico, Albuquerque, NM); Nordquist, Christopher Daniel; Feldner, Lucas Matthew

    2005-07-01

    A Ka-band RF MEMS enabled frequency reconfigurable triangular microstrip patch antenna has been designed for monolithic integration with RF MEMS phase shifters to demonstrate a low-cost monolithic passive electronically scanned array (PESA). This paper introduces our first prototype reconfigurable triangular patch antenna currently in fabrication. The aperture coupled patch antenna is fabricated on a dual-layer quartz/alumina substrate using surface micromachining techniques.

  17. RF MEMS reconfigurable triangular patch antenna.

    Energy Technology Data Exchange (ETDEWEB)

    Nordquist, Christopher Daniel; Christodoulou, Christos George (University of New Mexico, Albuquerque, NM); Feldner, Lucas Matthew

    2005-01-01

    A Ka-band RF MEMS enabled frequency reconfigurable triangular microstrip patch antenna has been designed for monolithic integration with RF MEMS phase shifters to demonstrate a low-cost monolithic passive electronically scanned array (PESA). This paper introduces our first prototype reconfigurable triangular patch antenna currently in fabrication. The aperture coupled patch antenna is fabricated on a dual-layer quartz/alumina substrate using surface micromachining techniques.

  18. Smart thermal patch for adaptive thermotherapy

    KAUST Repository

    Hussain, Muhammad Mustafa

    2015-11-12

    A smart thermal patch for adaptive thermotherapy is provided. In an embodiment, the patch can be a stretchable, non-polymeric, conductive thin film flexible and non-invasive body integrated mobile thermal heater with wireless control capabilities that can be used to provide adaptive thermotherapy. The patch can be geometrically and spatially tunable on various pain locations. Adaptability allows the amount of heating to be tuned based on the temperature of the treated portion.

  19. Patch layout generation by detecting feature networks

    KAUST Repository

    Cao, Yuanhao

    2015-02-01

    The patch layout of 3D surfaces reveals the high-level geometric and topological structures. In this paper, we study the patch layout computation by detecting and enclosing feature loops on surfaces. We present a hybrid framework which combines several key ingredients, including feature detection, feature filtering, feature curve extension, patch subdivision and boundary smoothing. Our framework is able to compute patch layouts through concave features as previous approaches, but also able to generate nice layouts through smoothing regions. We demonstrate the effectiveness of our framework by comparing with the state-of-the-art methods.

  20. The "edge effect" with patch test materials.

    Science.gov (United States)

    Fyad, A; Masmoudi, M L; Lachapelle, J M

    1987-03-01

    A positive "edge effect", i.e., the accumulation on the skin of a chemical solution (such as fluorescein 0.01% in a 50/50 water-ethanol solution) at the periphery of the patch test sites has been demonstrated. It occurs with different test materials (Finn Chamber; Silver Patch Test; Patch Test Chamber). Practical implications are discussed: this observation could be important when discussing results of laboratory investigations. In clinical practice, it could explain the occurrence of "ring-shaped" positive allergic patch test reactions to chemicals used in solution, i.e., Kathon CG or hydrocortisone.

  1. Performance of shcc with bacteria for concrete patch repair

    NARCIS (Netherlands)

    Sierra Beltran, M.G.; Jonkers, H.M.; Schlangen, E.

    2014-01-01

    The overall performance of concrete patch repair systems depends on the durability of and compatibility between the concrete substrate and the repair material. This paper investigates the performance of a new type of SHCC material with embedded bacteria as a repair material. The bacteria are a

  2. Estructura electrónica de superficies: estados de superficie y estados resonantes del calcio

    OpenAIRE

    H. Herrera; César Mora

    2006-01-01

    En este artículo presentamos un estudio detallado de la estructura electrónica de bandas de superficies orientadas (001) y (110) de cristales cúbicos centrados en la cara del Ca. Para nuestro estudio utilizamos la aproximación de enlace fuerte y el método de acoplamiento de la función de Green de superficie. Primero, construimos hamiltonianos de enlace fuerte en el formalismo de Slater Koster (SK). Utilizamos una base ortogonal de nueve orbitales atómicos (spd) por átomo en la celda unitaria....

  3. A Case of Patch Stage of Kaposi’s Sarcoma and Discussion of the Differential Diagnosis

    Science.gov (United States)

    Kak, Ipshita; Salama, Samih; Gohla, Gabriella; Naqvi, Asghar; Alowami, Salem

    2016-01-01

    A 55 year old HIV positive male had a skin lesion biopsy which showed atypical vascular proliferation within the superficial and deep dermis with mild atypia of lining endothelial cells. A sparse lymphoplasmacytic infiltrate surrounding the irregular vascular channels was noted. Immunohistochemistry highlighted the atypical blood vessels with the vascular markers CD31, CD34 and Factor VIII. The differential diagnosis included unusual vascular or lymphatic proliferations, stasis dermatitis, kaposiform hemangioendothelioma, progressive lymphangioma and angiosarcoma with focal Kaposi’s sarcoma features. Characteristic human herpes virus-8 positive staining helped support the diagnosis of patch stage of Kaposi’s sarcoma. Herein, we discuss the case findings, differential diagnosis and characteristic histological findings associated with the patch stage of Kaposi’s sarcoma which can be an elusive diagnosis. PMID:27134709

  4. Patch graft for corneal perforation following trivial trauma in bilateral terrien′s marginal degeneration

    Directory of Open Access Journals (Sweden)

    Merle Fernandes

    2015-01-01

    Full Text Available A young female presented with blurred vision in the left eye after she rubbed her eye. On examination of both eyes, she had 360° thinning adjacent to the limbus, lipid deposition and superficial vascularization with a perforation in the left eye. The patient was diagnosed with bilateral Terrien′s marginal degeneration (TMD with perforation. Corneal topography of the right eye revealed high oblique astigmatism confirming the diagnosis. A peripheral patch graft was performed for the left eye. At 18 months postoperatively, the best-corrected visual acuity was 20/20 in both eyes. The graft was clear. Topography of right eye was stable, and the left eye had oblique astigmatism. Bilateral advanced TMD in a young patient presenting with corneal perforation following trivial trauma is extremely uncommon. Patch graft may be an option for restoring the globe integrity in such cases. Regular follow-up is necessary as the condition progresses slowly.

  5. Reconfigurable Wideband Circularly Polarized Stacked Square Patch Antenna for Cognitive Radios

    Science.gov (United States)

    Barbosa Kortright, Miguel A.; Waldstein, Seth W.; Simons, Rainee N.

    2017-01-01

    An almost square patch, a square patch and a stacked square patch with corner truncation for circular polarization (CP) are researched and developed at X-band for cognitive radios. Experimental results indicate, first, that the impedance bandwidth of a CP almost square patch fed from the edge by a 50 ohm line is 1.70% and second, that of a CP square patch fed from the ground plane side by a surface launch connector is 1.87%. Third, the impedance bandwidth of a CP stacked square patch fed by a surface launch connector is 2.22%. The measured center frequency for the CP square patch fed by a surface launch connector without and with an identical stacked patch is 8.45 and 8.1017 GHz, respectively. By stacking a patch, separated by a fixed air gap of 0.254 mm, the center frequency is observed to shift by as much as 348.3 MHz. The shift in center frequency, brought about by the reconfiguring of the physical layer antenna, can be exploited in a cognitive system since it expands the usable frequency spectrum for software reconfiguration in the presence of interference. In addition, varying the fixed air gap in the stacked antenna geometry by increments of 0.254 mm further expands the usable frequency spectrum.

  6. A unique variation of superficial palmar arch

    Directory of Open Access Journals (Sweden)

    Jiji PJ

    2009-09-01

    Full Text Available We present a unique variation in the arterial pattern of superficial palmar arch in which it was completed by one of the large terminal branches of radial artery. The origin of the arteria radialis indicis was also peculiar that it was arising from the communicating branch of the radial artery and further reinforced by the first dorsal metacarpal artery that joined it after reaching the volar aspect. Pertinent anatomical knowledge regarding the variations of the palmar arch is significant for the purposes of microvascular repairs and re-implantations.

  7. E-SHAPED STACKED BROADBAND PATCH ANTENNA

    Directory of Open Access Journals (Sweden)

    Bharat Rochani

    2014-10-01

    Full Text Available A coaxial feed modified E-shaped patch antenna has been presented with parametric study of the antenna parameters. The proposed antenna is designed for WLAN and WiMAX applications from 5 – 6 GHz. The 5 – 6 GHz band has been chosen because it provides higher data rate (>50 Mbps for laptops, note-book computers and many new wireless digital applications devices without interference. Although current 5.0 GHz wireless computer network systems operated from 5.15 GHz – 5.35 GHz band. But in future, for faster data rate 5.725 – 5.85 GHz band becomes popular in addition to 5.15 – 5.35 GHz.

  8. A decision algorithm for patch spraying

    DEFF Research Database (Denmark)

    Christensen, Svend; Heisel, Torben; Walter, Mette

    2003-01-01

    It has been established that weeds are spatially aggregated with a spatially varying composition of weed species within agricultural fields. Site-specific spraying therefore requires a decision method that includes the spatial variation of the weed composition and density. A computerized decision...... method that estimates an economic optimal herbicide dose according to site-specific weed composition and density is presented in this paper. The method was termed a ‘decision algorithm for patch spraying’ (DAPS) and was evaluated in a 5-year experiment, in Denmark. DAPS consists of a competition model......, a herbicide dose–response model and an algorithm that estimates the economically optimal doses. The experiment was designed to compare herbicide treatments with DAPS recommendations and the Danish decision support system PC-Plant Protection. The results did not show any significant grain yield difference...

  9. PERSISTENCE AND GLOBAL STABILITY FOR A THREE-SPECIES RATIO-DEPENDENT PREDATOR-PREY SYSTEM WITH TIME DELAYS IN TWO-PATCH ENVIRONMENTS

    Institute of Scientific and Technical Information of China (English)

    徐瑞; 陈兰荪

    2002-01-01

    A three-species ratio-dependent predator-prey diffusion model with time delays is investigated. It is shown that the system is uniformly persistent under some appropriate conditions, and sufficient conditions are obtained for the global stability of the positive equilibrium of the system.

  10. Fast exact nearest patch matching for patch-based image editing and processing.

    Science.gov (United States)

    Xiao, Chunxia; Liu, Meng; Nie, Yongwei; Dong, Zhao

    2011-08-01

    This paper presents an efficient exact nearest patch matching algorithm which can accurately find the most similar patch-pairs between source and target image. Traditional match matching algorithms treat each pixel/patch as an independent sample and build a hierarchical data structure, such as kd-tree, to accelerate nearest patch finding. However, most of these approaches can only find approximate nearest patch and do not explore the sequential overlap between patches. Hence, they are neither accurate in quality nor optimal in speed. By eliminating redundant similarity computation of sequential overlap between patches, our method finds the exact nearest patch in brute-force style but reduces its running time complexity to be linear on the patch size. Furthermore, relying on recent multicore graphics hardware, our method can be further accelerated by at least an order of magnitude (≥10×). This greatly improves performance and ensures that our method can be efficiently applied in an interactive editing framework for moderate-sized image even video. To our knowledge, this approach is the fastest exact nearest patch matching method for high-dimensional patch and also its extra memory requirement is minimal. Comparisons with the popular nearest patch matching methods in the experimental results demonstrate the merits of our algorithm. © 2011 IEEE

  11. Clinical Evaluation of Superficial Fungal Infections in Children

    Directory of Open Access Journals (Sweden)

    Ragıp Ertaş

    2015-12-01

    Full Text Available Objective: This retrospective study was referred to evaluate 51 cases of superficial mycoses, referred to our Pediatric Dermatology outpatient clinic in one year. Methods: We reviewed following data for all patients: age, gender, accompanied diseases, clinical types, localization and treatment. Superficial mycotic infections were diagnosed on the basis of clinical picture, direct microscopy and some of them were confirmed by fungal cultures. Results: Our patients comprised 33 boys (64.7% and 18 girls (35.3%, with an average age of 6.2 years (range 4 months to 17 years. Eighteen patients (35.3% had dermatophytes on the scalp. Clinical forms, in the order of frequency, were: tinea capitis profunda in 10 patients (19.6%, tinea capitis superficialis in 8 patients (15.8%, tinea unguium in 8 patients (15.8%. Tinea capitis (35.3% was the most frequent form of dermatomycosis. The most common symptom was the pruritus. Thirty (58% patients were treated with local antimycotics and 21 (42% patients were treated with systemic terbinafine or itraconazole. Conclusion: In this study it was found that, tinea capitis was the most frequent form of dermatomycosis and onychomycosis in children are not uncommon as it is mentioned. The data also suggest that topical antifungal agents may be effective and well-tolerated in the treatment of onychomycosis and tinea capitis in children.

  12. Suction based mechanical characterization of superficial facial soft tissues.

    Science.gov (United States)

    Weickenmeier, J; Jabareen, M; Mazza, E

    2015-12-16

    The present study is aimed at a combined experimental and numerical investigation of the mechanical response of superficial facial tissues. Suction based experiments provide the location, time, and history dependent behavior of skin and SMAS (superficial musculoaponeurotic system) by means of Cutometer and Aspiration measurements. The suction method is particularly suitable for in vivo, multi-axial testing of soft biological tissue including a high repeatability in subsequent tests. The campaign comprises three measurement sites in the face, i.e. jaw, parotid, and forehead, using two different loading profiles (instantaneous loading and a linearly increasing and decreasing loading curve), multiple loading magnitudes, and cyclic loading cases to quantify history dependent behavior. In an inverse finite element analysis based on anatomically detailed models an optimized set of material parameters for the implementation of an elastic-viscoplastic material model was determined, yielding an initial shear modulus of 2.32kPa for skin and 0.05kPa for SMAS, respectively. Apex displacements at maximum instantaneous and linear loading showed significant location specificity with variations of up to 18% with respect to the facial average response while observing variations in repeated measurements in the same location of less than 12%. In summary, the proposed parameter sets for skin and SMAS are shown to provide remarkable agreement between the experimentally observed and numerically predicted tissue response under all loading conditions considered in the present study, including cyclic tests.

  13. Superficial microcirculation flow measurement using polarized light

    Science.gov (United States)

    Wu, Jiwei; Morgan, S. P.; Xiao, Yunshi

    2008-12-01

    Depth discrimination of polarized light is used in investigating laser Doppler measurement of the superficial microcirculation in tissue. Using polarization Monte Carlo simulation, temporal point spread function and power spectral distribution of backscattered polarization remaining light firstly are used to prove polarized light to be valid in measuring moving blood cell perfusion and mean flow velocity. Then simulation of layered medium model demonstrate that relationships between blood flow perfusion and mean frequency shift are linear to medium flowing velocity, and the Doppler shift information in polarization remaining light mainly comes from lower layer medium up to about 14 times of mean free path (MFP) of medium investigated and can be considered that Doppler effects come only from lower layer of the medium. Simulations in three-layer tissue model show that moving blood cell perfusion and mean blood cell moving velocity calculated from polarization remaining are much more sensitive to lower layer flow velocity variation, and more irrelevant to deeper layer flow rate fluctuations, that further confirms Doppler measurement from polarization remaining light to be effective for superficial microcirculation in tissue. Factors affecting Laser Doppler measurement like medium absorption, percentage of moving particles in blood detector size are discussed.

  14. Formulation of unidirectional release buccal patches of carbamazepine and study of permeation through porcine buccal mucosa

    Directory of Open Access Journals (Sweden)

    Parthasarathy Govindasamy

    2013-12-01

    Conclusions: The prepared unidirectional buccal patches of carbamazepine provided a maximum drug release within specified mucoadhesion period and it indicates a potential alternative drug delivery system for systemic delivery of carbamazepine.

  15. Formulation study of tea tree oil patches.

    Science.gov (United States)

    Minghetti, Paola; Casiraghi, Antonella; Cilurzo, Francesco; Gambaro, Veniero; Montanari, Luisa

    2009-01-01

    The antimicrobial, antifungal and anti-inflammatory properties of tea tree oil (TTO), the essential oil of Melaleuca alternifolia are well documented. In order to optimize its therapeutic activity, TTO patches were designed. The aim of this work was the formulation of monolayer patches containing TTO. Moreover, the performance of oleic acid (OA) as a skin penetration enhancer in patches was evaluated. Terpinen-4-ol (T4OL), the main component of TTO, was the marker used to evaluate TTO skin permeability. The permeation study was performed through human epidermis by using Franz diffusion cells. Patches were prepared by using methacrylic copolymers, Eudragit E100 (EuE100) or Eudragit NE (EuNE), and a silicone resin, BioPSA7-4602 (Bio-PSA). TTO and OA contents were fixed at 10% w/w and 3% w/w, respectively. The patches were prepared by a casting method and characterised in terms of T4OL content and skin permeability. All the selected polymers were suitable as the main component of the patch matrix. Since the main critical issue in the use of TTO is related to its toxicity after absorption, the local administration of TTO can take advantage of the use of patches based on EuE100 because of the high retained amount and the low permeation of T4OL. In this matrix, OA slightly increased the T4OL retained amount, improving the efficacy and safety of TTO patches.

  16. Streamlining of Plant Patches in Streams

    DEFF Research Database (Denmark)

    Sand-Jensen, Kaj; Pedersen, Morten Lauge

    2008-01-01

    area or root area was significantly lower in shallow water . Canopy shape and indices of streamlining did not change significantly with approach velocity (0.02-0.40 m s)1), either because canopy shape is not sensitive to approach velocity or summer velocities were too low to induce such changes. 3......1. Plants in shallow streams often grow in well-defined monospecific patches experiencing a predictable unidirectional flow, though of temporally variable velocity. During maximum patch development in summer we studied: (i) the shape and streamlining of 59 patches of Callitriche cophocarpa, (ii...... averaged 0.25. The canopy and root area of the patches were more elongate and slender in sites with shallow water, where currents accelerate alongside patches and restrict lateral expansion, compared to deeper sites where currents can pass above the canopy. Similarly, the frontal area relative to planform...

  17. Patch scales in coastal ecosystems

    Science.gov (United States)

    Broitman, Bernardo R.

    Quantifying the spatial and temporal scales over which ecological processes are coupled to environmental variability is a major challenge for ecologists. Here, I assimilate patterns of oceanographic variability with ecological field studies in an attempt to quantify spatial and temporal scales of coupling. Using coastal time series of chlorophyll-a concentration from remote sensing, the first chapter examines the alongshore extent of coastal regions subject to similar temporal patterns of oceanographic variability in Western North America (WNA) and North-Central Chile (Chile). I found striking interhemispherical differences in the length of coastal sections under similar oceanographic regimes, with the Chile region showing longshore coherency over much smaller spatial scales (˜60 km) than on the coast of WNA (˜140 km). Through a spatial analysis of coastal orientation I suggest that the characteristic length scales may be traced to the geomorphologic character of the ocean margins. The second chapter examines spatial patterns of primary production through long-term means of coastal chlorophyll-a concentration and kelp (Macrocystis pyrifera) cover and explores their relationship with coastal geomorphology and sea surface temperature (SST). Spatial analyses showed a striking match in length scales around 180--250 km. Strong anticorrelations at small spatial lags and positive correlations at longer distances suggest little overlap between patches of kelp and coastal chlorophyll-a. In agreement with findings from the previous chapter, I found that coastal patches could be traced back to spatial patterns of coastal geomorphology. Through SST time series and long-term datasets of larval recruitment in Santa Cruz Island, California, the third chapter examines temporal patterns of oceanographic variability as determinants of ecological patterns. SST time series from sites experiencing low larval recruitment rates were dominated by strong temporal variability. These sites

  18. Neurothekeoma palpebrae in association with multiple superficial angiomyxomas: Tegumental Angiomyxoma- Neurothekeoma syndrome (TAN syndrome

    Directory of Open Access Journals (Sweden)

    Tan Aik Kah

    2011-09-01

    Full Text Available We report a case of 10-year-old Indian girl with history of multiple superficial angiomyxoma, presented with three months history of painless right upper lid swelling. There were no visual dysfunctions. Previously, the patient had multiple superficial angiomyxoma (left pinna, left upper cheek, left upper limb, chest, right axilla, hard palate and epidermal cyst (chin. The histopathological specimens were negative to S-100 protein antibody. Systemic review and family history was unremarkable. Excision biopsy and upper lid reconstruction were performed. Intraoperatively the tumor was multilobulated, firm, well encapsulated and did not invade the underlying tarsal plate. Histopathological features of the upperlid tumor were consistent with nerves sheath myxoma (neurothekeoma. To the best of the authors’ knowledge, this is the first reported case of neurothekeoma in association with multiple superficial angiomyxoma.

  19. Superficial composition in binary solid solutions A(B): Drastic effect of pure element surface tensions

    Science.gov (United States)

    Rolland, A.; Aufray, B.

    1985-10-01

    This paper deals with a comparative study of surface segragation of Pb and Ni respectively from Ag(Pb)(111) and Ag(Ni)(111) solid solutions. A high level of segregation of the solute is observed for both systems characterized by very low solute solubility. However, the superficial composition strongly depends on the relative surface tensions of the pure elements: the solute atoms are strictly on superficial sites when γ solute is smaller than γ solvent; in contrast uppermost layer consists purely of solvent when γ solute is greater than γ solvent. Two schematic distributions in close proximity to the surface are proposed in the last case.

  20. Image quality assessment based on inter-patch and intra-patch similarity.

    Directory of Open Access Journals (Sweden)

    Fei Zhou

    Full Text Available In this paper, we propose a full-reference (FR image quality assessment (IQA scheme, which evaluates image fidelity from two aspects: the inter-patch similarity and the intra-patch similarity. The scheme is performed in a patch-wise fashion so that a quality map can be obtained. On one hand, we investigate the disparity between one image patch and its adjacent ones. This disparity is visually described by an inter-patch feature, where the hybrid effect of luminance masking and contrast masking is taken into account. The inter-patch similarity is further measured by modifying the normalized correlation coefficient (NCC. On the other hand, we also attach importance to the impact of image contents within one patch on the IQA problem. For the intra-patch feature, we consider image curvature as an important complement of image gradient. According to local image contents, the intra-patch similarity is measured by adaptively comparing image curvature and gradient. Besides, a nonlinear integration of the inter-patch and intra-patch similarity is presented to obtain an overall score of image quality. The experiments conducted on six publicly available image databases show that our scheme achieves better performance in comparison with several state-of-the-art schemes.

  1. Transmucosal delivery of oxytocin to rabbits using a mucoadhesive buccal patch.

    Science.gov (United States)

    Li, C; Bhatt, P P; Johnston, T P

    1997-08-01

    A biocompatible, mucoadhesive buccal patch was evaluated in rabbits for transmucosal delivery of peptides. Oxytocin (OT) was incorporated into custom coformulations of Carbopol 974P and silicone polymer and the resulting plasma OT concentration versus time profiles determined following patch application. For comparative purposes, the mean values determined for the elimination half-life (t1/2), volume of distribution (Vd), and the total body clearance (CL) following intravenous injection of OT were 2.9 +/- 0.2 min, 85.3 +/- 6.7 ml, and 20.4 +/- 2.03 ml/min, respectively. Following application of oxytocin-loaded mucoadhesive patches, plasma OT concentrations remained 20- to 28-fold greater from 0.5 to 3.0 hr than control animals administered placebo patches. The steady-state plasma OT concentration (Css) following application of the buccal patches was 80.6 +/- 15.9 pg/ml. The lag-time associated with attainment of the Css was 0.45 +/- 0.18 hr. Steady-state flux (Jss) of oxytocin in vivo was 139 +/- 36.8 ng/hr/cm2. Based on the amount of OT remaining in the patches following removal, the average dose of OT released in vivo was 0.27 +/- 0.024 mg with a bioavailability of 0.1%. No significant alterations in mucosal histology were observed when underlying mucosa to which OT patches had been applied were compared to either control (no patch) mucosa or mucosa underneath placebo patches. The mucoadhesive buccal patches were easy to apply and remove, nonirritating to tissue, and able to continuously deliver a nonapeptide over 3 hr. Based on these preliminary studies, the mucoadhesive buccal patches evaluated may represent an improved transmucosal drug delivery system for peptides and conventional drug substances.

  2. Assessment of patches attributes along the Urban Development Gradient

    Science.gov (United States)

    Kopel, Daniella; Wittenberg, lea; Malkinson, Dan

    2014-05-01

    The world is increasingly urban. If current trends maintain, by 2050 the global urban population is estimated to be 6.3 billion, nearly doubling the world population in 2010. Consequently, more than 60% of the area projected to be urban in 2030 has yet to be built, replacing the open and agriculture lands with construction and infrastructure. The open green patches (OGP), within the urban matrix, are essential for healthy and wellness of cities by supplying the city's ecological services (Mausback and Seybold, 1998). Regarding future trends, there is a need and obligation to insure the functional and sustainability of the city's OPG. Urban vegetation composition and diversity in the OGP had long been considered as an indication for ecologically functioning systems. Furthermore, urban soil is also essential for the sustainability and function of the urban habitat and ecological services, such as maintaining groundwater restraining urban floods etc. (Lehmann and Stahr 2007). There is no single set of rules to classify a functional urban green patch worth preserving. The aim of this study is to examine the effects of patch properties (including geometry, age, type and location along the urban gradient, connectivity, and urban matrix density) on the presence, abundance and characteristics of vegetation and soil conditions of remnant patches The inspired purpose is to eventually find an assessment for urban open green patches OGP quality by linking, patches attributes, plants indexes and soil quality indexes The research is conducted in the city of Haifa, which is located on the northern part of Mount Carmel in the north-western part of Israel . Mean annual rainfall, 550-800 mm, varies with latitude and the mean temperature is 18.80c. Modern Haifa is a relatively young city which maintains remnant vegetation patches within its municipal boundary. 32 OGP were selected in nine categories (size: small, medium and large, distance from city edge: far, average, near), in

  3. Patch test results of the European baseline series among patients with occupational contact dermatitis across Europe - analyses of the European Surveillance System on Contact Allergy network, 2002-2010.

    Science.gov (United States)

    Pesonen, Maria; Jolanki, Riitta; Larese Filon, Francesca; Wilkinson, Mark; Kręcisz, Beata; Kieć-Świerczyńska, Marta; Bauer, Andrea; Mahler, Vera; John, Swen M; Schnuch, Axel; Uter, Wolfgang

    2015-03-01

    Occupational contact dermatitis is one of the most common occupational diseases in Europe. In order to develop effective preventive measures, detailed and up-to-date data on the incidence, main causes and professions at risk of occupational contact dermatitis are needed. To describe the pattern of patch test reactivity to allergens in the European baseline series of patients with occupational contact dermatitis in different occupations. We analysed data collected by the European Surveillance System on Contact Allergy (ESSCA) network from 2002 to 2010, from 11 European countries. Allergens in the European baseline series associated with an at least doubled risk of occupational contact dermatitis include: thiuram rubber chemical accelerators, epoxy resin, and the antimicrobials methylchloroisothiazolinone/methylisothiazolinone, methyldibromo glutaronitrile, and formaldehyde. The highest risk of occupational contact dermatitis was found in occupations classified as 'other personal services workers', which includes hairdressers, nursing and other healthcare professionals, precision workers in metal and related materials, and blacksmiths, tool-makers and related trades workers. In the planning and implementation of measures aimed at preventing occupational contact dermatitis, the focus should be on the identified high-risk occupational groups and the most common occupational allergies. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  4. Prospective analysis of laparoscopic ventral hernia repair using the Ventralight™ ST hernia patch with or without the ECHO PS™ positioning system.

    Science.gov (United States)

    Tollens, Tim; Topal, Halit; Vermeiren, Koen; Aelvoet, Chris

    2014-03-01

    The purpose of the current prospective study was to confirm the results of our previous study on the use of the Ventralight™ ST mesh. In this study we also evaluated a pre-attached positioning system. Between July 2011 and October 2013 prospectively collected data of 61 consecutive patients who underwent a laparoscopic ventral hernia repair were analyzed. Short- and long-term outcomes were described. A total of 61 patients were treated in this period (men/women ratio 44/17). Overall median follow-up was 7 months (range 2-29). There were 30 patients with a follow-up of at least 12 months. Mean hernia diameter was 6 x 5 cm (craniocaudal x laterolateral) (range 1.5 x 1.5 to 20 x 15 cm). Overall mean length of hospital stay was 4.4 days. Postoperative visual analog scale (VAS) at last follow-up was significantly lower than the preoperative VAS (3.01 vs 0.68; P = 0.011) There were no intraoperative complications. In the whole group, only 6 patients (10%) showed minor complications. Four patients had mild discomfort, another 2 patients developed a clinically significant seroma. The complication rate in the subgroup with a follow-up of at least 1 year was 13%. No recurrences were observed. This study confirms our preliminary findings on the use of this mesh. The optional positioning system offers a significantly more quick and proper mesh positioning.

  5. Metabolomic change precedes apple superficial scald symptoms.

    Science.gov (United States)

    Rudell, David R; Mattheis, James P; Hertog, Maarten L A T M

    2009-09-23

    Untargeted metabolic profiling was employed to characterize metabolomic changes associated with 'Granny Smith' apple superficial scald development following 1-MCP or DPA treatment. Partial least-squares discriminant analyses were used to link metabolites with scald, postharvest treatments, and storage duration. Models revealed metabolomic differentiation between untreated controls and fruit treated with DPA or 1-MCP within 1 week following storage initiation. Metabolic divergence between controls and DPA-treated fruit after 4 weeks of storage preceded scald symptom development by 2 months. alpha-Farnesene oxidation products with known associations to scald, including conjugated trienols, 6-methyl-5-hepten-2-one, and 6-methyl-5-hepten-2-ol, were associated with presymptomatic as well as scalded control fruit. Likewise, a large group of putative triterpenoids with mass spectral features similar to those of ursolic acid and beta-sitosterol were associated with control fruit and scald. Results demonstrate that extensive metabolomic changes associated with scald precede actual symptom development.

  6. Condiciones de la superficie deslizamiento con falla

    Directory of Open Access Journals (Sweden)

    María Cecilia Sierra B.

    2011-06-01

    Full Text Available Se modelan seis (6 taludes can diferentes ángulos de inclinación y peso unitario de 1.8 ton/m3, módulo de Young de 500 ton/m2 y relación de Poisson de 0.45. En cada uno de estos taludes se calculan los esfuerzos a través del talud y se determinan los puntos que están sometidos a mayores esfuerzos cortantes, correspondiendo estos a los estados de esfuerzos mas críticos, La ubicación de estos puntos es por donde comenzará y terminará la superficie de falla. Se obtiene un gráfico de diseño que permite obtener la pendiente máxima que debe tener un talud para que no se presente falla local en ningún punto.

  7. Evaluation of adhesive properties of patches based on acrylic matrices.

    Science.gov (United States)

    Minghetti, P; Cilurzo, F; Montanari, L

    1999-01-01

    Adhesion is an essential property of the dermal and transdermal therapeutic systems (TS). It is influenced by the composition and the thickness of the matrix and also by the characteristics of the backing layer. Our aim was to evaluate the usefulness of the "thumb tack test," the "tack rolling ball test," and the "peel adhesion 180 degrees test" in the development studies and quality control of TS. These tests were performed on two series of placebo patches in which the backing layer was made of artificial silk (series 1) and polyurethane film (series 2). The patches of both series were prepared using five different mixtures of a hydrophilic adhesive copolymer and a hydrophobic nonadhesive copolymer as matrices. Plastoid E 35 L, a copolymer of dimethylaminoethyl methacrylate and neutral methacrylic esters, was used as the adhesive polymer. Eudragit NE 40 D, a copolymer of ethylacrylate and methylmethacrylate, was used as the nonadhesive copolymer. In the standard procedure for the peel adhesion 180 degrees test, used in the tape industries, the adherent is made of stainless steel. Because the latter has a high surface energy, it was not suitable for the analysis of the patches with a polyurethane backing layer. Therefore, the critical surface tension of five alternative materials (rubber, polysiloxane, polyethylene, nylon, polyvinyl chloride) was evaluated. Polyethylene was selected for the modified peel adhesion 180 degrees test, and better results were obtained in terms of feasibility of the test and ability to discriminate between the different patches prepared.

  8. The flexural stiffness of superficial neuromasts in the zebrafish (Danio rerio) lateral line

    NARCIS (Netherlands)

    McHenry, Matthew J.; van Netten, Sietse M.

    2007-01-01

    Superficial neuromasts are structures that detect water flow on the surface of the body of fish and amphibians. As a component of the lateral line system, these receptors are distributed along the body, where they sense flow patterns that mediate a wide variety of behaviors. Their ability to detect

  9. The flexural stiffness of superficial neuromasts in the zebrafish (Danio rerio) lateral line

    NARCIS (Netherlands)

    McHenry, Matthew J.; van Netten, Sietse M.

    2007-01-01

    Superficial neuromasts are structures that detect water flow on the surface of the body of fish and amphibians. As a component of the lateral line system, these receptors are distributed along the body, where they sense flow patterns that mediate a wide variety of behaviors. Their ability to detect

  10. An Electronic Patch for Wearable Health Monitoring by Reflectance Pulse Oximetry

    DEFF Research Database (Denmark)

    Haahr, Rasmus Grønbek; Duun, Sune Bro; Toft, Mette H.;

    2012-01-01

    We report the development of an Electronic Patch for wearable health monitoring. The Electronic Patch is a new health monitoring system incorporating biomedical sensors, microelectronics, radio frequency (RF) communication, and a battery embedded in a 3-dimensional hydrocolloid polymer...... photodiode to enable low power consumption by the light emitting components. The Electronic Patch has a disposable part of soft adhesive hydrocolloid polymer and a reusable part of hard polylaurinlactam. The disposable part contains the battery. The reusable part contains the reflectance pulse oximetry....... In this paper the Electronic Patch is demonstrated with a new optical biomedical sensor for reflectance pulse oximetry so that the Electronic Patch in this case can measure the pulse and the oxygen saturation. The reflectance pulse oximetry solution is based on a recently developed annular backside silicon...

  11. Pattern Reconfigurable Wideband Stacked Microstrip Patch Antenna for 60 GHz Band

    Directory of Open Access Journals (Sweden)

    Alexander Bondarik

    2016-01-01

    Full Text Available A beam shift method is presented for an aperture coupled stacked microstrip antenna with a gridded parasitic patch. The gridded parasitic patch is formed by nine close coupled identical rectangular microstrip patches. Each of these patches is resonant at the antenna central frequency. Using four switches connecting adjacent parasitic patches in the grid, it is possible to realize a pattern reconfigurable antenna with nine different beam directions in broadside, H-plane, E-plane, and diagonal planes. The switches are modeled by metal strips and different locations for strips are studied. As a result an increase in the antenna coverage is achieved. Measurement results for fabricated prototypes correspond very well to simulation results. The antenna is designed for 60 GHz central frequency and can be used in high speed wireless communication systems.

  12. Dissociation of μ- and δ-opioid inhibition of glutamatergic synaptic transmission in superficial dorsal horn

    Directory of Open Access Journals (Sweden)

    Vaughan Christopher W

    2010-10-01

    Full Text Available Abstract Background There is anatomical and behavioural evidence that μ- and δ-opioid receptors modulate distinct nociceptive modalities within the superficial dorsal horn. The aim of the present study was to examine whether μ- and δ-opioid receptor activation differentially modulates TRP sensitive inputs to neurons within the superficial dorsal horn. To do this, whole cell patch clamp recordings were made from lamina I - II neurons in rat spinal cord slices in vitro to examine the effect of opioids on TRP agonist-enhanced glutamatergic spontaneous miniature excitatory postsynaptic currents (EPSCs. Results Under basal conditions the μ-opioid agonist DAMGO (3 μM reduced the rate of miniature EPSCs in 68% of neurons, while the δ- and κ-opioid agonists deltorphin-II (300 nM and U69593 (300 nM did so in 13 - 17% of neurons tested. The TRP agonists menthol (400 μM and icilin (100 μM both produced a Ca2+-dependent increase in miniature EPSC rate which was unaffected by the voltage dependent calcium channel (VDCC blocker Cd2+. The proportion of neurons in which deltorphin-II reduced the miniature EPSC rate was enhanced in the presence of icilin (83%, but not menthol (0%. By contrast, the proportion of DAMGO and U69593 responders was unaltered in the presence of menthol (57%, 0%, or icilin (57%, 17%. Conclusions These findings demonstrate that δ-opioid receptor activation selectively inhibits inputs activated by icilin, whereas μ-opioid receptor activation has a more widespread effect on synaptic inputs to neurons in the superficial dorsal horn. These findings suggest that δ-opioids may provide a novel analgesic approach for specific, TRPA1-like mediated pain modalities.

  13. A new patch antenna with metamaterial cover

    Institute of Scientific and Technical Information of China (English)

    HU Jun; YAN Chun-sheng; LIN Qing-chun

    2006-01-01

    A metamaterial was introduced into the cover of a patch antenna and its band structure was analyzed. The metamaterial cover with correct selection of the working frequency increases by 9.14 dB the patch antenna's directivity. The mechanism of metamaterial cover is completely different from that of a photonic bandgap cover. The mechanism of the metamaterial cover,the number of the cover's layers, and the distance between the layers, were analyzed in detail. The results showed that the metamaterial cover, which works like a lens, could effectively improve the patch antenna's directivity. The physical reasons for the improvement are also given.

  14. Superficial Granulomatous Pyoderma Gangrenosum of the Penis: A Case Report

    Directory of Open Access Journals (Sweden)

    Shyamala S. Gopi

    2006-01-01

    Full Text Available Classic type of pyoderma gangrenosum (PG is an uncommon ulceronecrotic cutaneous disease of uncertain aetiology characterised by broad zones of confluent ulceration with violaceous undermined margins. Some 50% of cases are associated with systemic diseases. The superficial granulomatous variant of pyoderma gangrenosum (SGPG of the external genitalia is extremely rare Patients with this condition develop single or multiple ulcerated skin lesions often with sinus tract formation. The majority of these lesions were found on the trunk and limbs. SGPG is less likely to be associated with underlying disease processes than classic PG. We present a 58 year-old with recalcitrant penile ulceration demonstrated to be SGPG on biopsy. Although rare and poorly recognised, the histological features are sufficiently typical to allow the correct diagnosis to be established.

  15. Surface application of gypsum in low acidic Oxisol under no-till cropping system Aplicação superficial de gesso num Latossolo de baixa acidez sob sistema plantio direto

    Directory of Open Access Journals (Sweden)

    Eduardo Fávero Caires

    2011-04-01

    Full Text Available The conditions in which a favorable response to a gypsum application can be expected on crop yields are not clear. A 3-year field trial was carried out to evaluate the effects of gypsum application on soil chemical attributes and nutrition and yield of corn (Zea mays L. and soybean (Glycine max L. Merrill on a clayey Typic Hapludox of high fertility and low acidity under no-till in Guarapuava, Parana State, Brazil. Treatments were arranged in a randomized complete block design with four replications, and consisted of gypsum application on the soil surface at 4, 8, and 12 Mg ha-1. Gypsum application increased the P content in the soil most superficial layer (0.0 - 0.1 m and also the exchangeable Ca and S-SO4(2- contents and the Ca/Mg ratio in the soil profile (0.0 - 0.6 m. Gypsum also caused leaching of Mg and K exchangeable in the soil. An increase in Ca concentrations in the corn leaves, and in P and S concentrations in the corn and soybean leaves occurred following the gypsum application. A yield response of corn to initial application of gypsum was found, but subsequent soybean crops did not respond. Gypsum application proved to be an effective practice to maximize no-till corn grain yield.Não estão claras as condições em que se podem esperar efeitos favoráveis da aplicação de gesso na produção das culturas. Em um experimento de campo avaliaram-se, durante três anos, os efeitos da aplicação de gesso nos atributos químicos de um Latossolo Vermelho argiloso de alta fertilidade e baixa acidez sob plantio direto e na nutrição e produção de milho (Zea mays L. e soja (Glycine max L. Merrill, em Guarapuava (PR. Os tratamentos, dispostos em blocos completos ao acaso com quatro repetições, constaram da aplicação superficial de gesso nas doses 4, 8 e 12 Mg ha-1. A aplicação de gesso aumentou a concentração de P na camada mais superficial (0.0 - 0,1 m, bem como os teores de Ca trocável e de S-SO4(2- e a relação Ca/Mg no

  16. Volumetric and superficial characterization of carbon activated; Caracterizacion volumetrica y superficial de carbon activado

    Energy Technology Data Exchange (ETDEWEB)

    Carrera G, L.M.; Garcia S, I.; Jimenez B, J.; Solache R, M.; Lopez M, B.; Bulbulian G, S.; Olguin G, M.T. [Departamento de Quimica, Gerencia de Ciencias Basicas, Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    2000-07-01

    The activated carbon is the resultant material of the calcination process of natural carbonated materials as coconut shells or olive little bones. It is an excellent adsorbent of diluted substances, so much in colloidal form, as in particles form. Those substances are attracted and retained by the carbon surface. In this work is make the volumetric and superficial characterization of activated carbon treated thermically (300 Centigrade) in function of the grain size average. (Author)

  17. Avaliação da rugosidade superficial de três resinas compostas submetidas a diferentes técnicas de polimento Evaluation of the superficial roughness of three composite resins submitted to different polishing techniques

    Directory of Open Access Journals (Sweden)

    Benícia Carolina Iaskieviscz RIBEIRO

    2001-09-01

    Full Text Available Neste estudo, avaliou-se a rugosidade superficial de resinas classificadas como compactáveis e uma híbrida tradicional comparando-se diferentes técnicas de polimento. Confeccionaram-se corpos-de-prova, que foram armazenados em água destilada por 24 horas e posteriormente submetidos a duas técnicas de tratamento superficial, em que foram empregados dois sistemas de discos de acabamento e polimento e pontas siliconizadas. Os resultados revelaram maior rugosidade superficial da resina AlertTM em relação a Solitaire® e Degufill Mineral®, não havendo diferenças estatisticamente significantes entre as últimas citadas. A rugosidade superficial das restaurações cujo polimento foi executado com as pontas Enhance® foi maior que o polimento obtido com os sistemas de discos, não havendo diferenças estatisticamente significante entre esses.In this study, the superficial roughness of two composite resins classified as condensable and of a traditional hybrid composite resin was analyzed after different polishing techniques. Test specimens were confected, immersed in distilled water for 24 hours and submitted to two different techniques of superficial treatment, in which disc systems (Sof-LexTM and Super Snap® and silicon tips (Enhance® were utilized. The results revealed the greater superficial roughness of AlertTM, when compared with Solitaire® and Degufill Mineral® - no statistically significant differences were observed between the last two materials. The superficial roughness of the specimens polished with Enhance® tips was greater than that of the specimens polished with discs and there were no statistically significant differences between both disc systems.

  18. Traumatic aneurysm of superficial temporal artery. CT demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, A.; Tyagi, G.; Sahai, A.; Baijal, S.S. (G.B. Pant Hospital and M.A. Medical Coll., New Delhi (India). Dept. of Neurosurgery G.B. Pant Hospital and M.A. Medical Coll., New Delhi (India). Dept. of Radiology)

    1991-12-01

    A case of traumatic pseudo-aneurysm of the superficial temporal artery documented on Computed tomography (CT) and angiography is described in a 55-year-old female, who was treated by surgical excision. Computed tomographic appearance of this lesion is illustrated. This represents, to our knowledge, the first CT demonstration of traumatic aneurysm of superficial temporal artery within a large subgaleal haematoma. (orig.).

  19. Risk factors associated with acquiring superficial fungal infections in ...

    African Journals Online (AJOL)

    school children in South Western Nigeria: a comparative study. Olaide Oke Olutoyin1, Olaniyi ... Keywords: Risk factors, school children, skin, superficial fungal infections. ..... study with poor hygiene, malnutrition, overcrowding and poor general social ... cial determinants of health that influence the presence of superficial ...

  20. Computer modeling of endovascular patch welding using temperature feedback

    Energy Technology Data Exchange (ETDEWEB)

    Glinsky, M.E.; London, R.A.; Zimmerman, G.B. [Lawrence Livermore National Lab., CA (United States); Jacques, S.L. [Anderson (M.D.) Cancer Center, Houston, TX (United States); Ols, J.D. [Ols & Associates, Mountain View, CA (United States)

    1995-11-01

    A new computer program, LATIS, being developed at Lawrence Livermore National Laboratory is used to study the effect of pulsed laser irradiation with temperature feedback on endovascular patch welding. Various physical and biophysical effects are included in these simulations: laser light scattering and absorption, tissue heating and heat conduction, vascular cooling, and tissue thermal damage. The geometry of a patch being held against the inner vessel wall (500 {mu}m inner diameter) by a balloon is considered. The system is exposed to light pulsed from an optical fiber inside the balloon. The laser power is adjusted during the course of a pulse. This is done automatically in the simulation by temperature feedback. A minimum in the depth of damage into the vessel wall is found. The minimum damage zone is about the thickness of the patch material that is heated by the laser. The more ordered the tissue the thinner the minimum zone of damage. The pulse length which minimizes the zone of damage is found to be the time for energy to diffuse across the layer. The delay time between the pulses is determined by the time for the heated layer to cool down. An optimal pulse length exists which minimizes the total time needed to weld the patch to the wall while keeping the thickness of the damaged tissue to less than 100 {mu}m. For the case that is considered, a patch dyed with light absorbing ICG on the side next to the vessel (thickness of the dyed layer is 60 {mu}m), the best protocol is found to be 33-600 ms pulses applied over 1.6 min.

  1. Can Stem Cell 'Patch' Help Heart Failure?

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_164475.html Can Stem Cell 'Patch' Help Heart Failure? Small improvement seen over ... Scientists report another step in the use of stem cells to help treat people with debilitating heart failure. ...

  2. Accuracy of a new patch pump based on a microelectromechanical system (MEMS) compared to other commercially available insulin pumps: results of the first in vitro and in vivo studies.

    Science.gov (United States)

    Borot, Sophie; Franc, Sylvia; Cristante, Justine; Penfornis, Alfred; Benhamou, Pierre-Yves; Guerci, Bruno; Hanaire, Hélène; Renard, Eric; Reznik, Yves; Simon, Chantal; Charpentier, Guillaume

    2014-11-01

    The JewelPUMP™ (JP) is a new patch pump based on a microelectromechanical system that operates without any plunger. The study aimed to evaluate the infusion accuracy of the JP in vitro and in vivo. For the in vitro studies, commercially available pumps meeting the ISO standard were compared to the JP: the MiniMed® Paradigm® 712 (MP), Accu-Chek® Combo (AC), OmniPod® (OP), Animas® Vibe™ (AN). Pump accuracy was measured over 24 hours using a continuous microweighing method, at 0.1 and 1 IU/h basal rates. The occlusion alarm threshold was measured after a catheter occlusion. The JP, filled with physiological serum, was then tested in 13 patients with type 1 diabetes simultaneously with their own pump for 2 days. The weight difference was used to calculate the infused insulin volume. The JP showed reduced absolute median error rate in vitro over a 15-minute observation window compared to other pumps (1 IU/h): ±1.02% (JP) vs ±1.60% (AN), ±1.66% (AC), ±2.22% (MP), and ±4.63% (OP), P pumps: 21 (19; 25) minutes vs 90 (85; 95), 58 (42; 74), and 143 (132; 218) minutes (AN, AC, MP), P pumps (-2.2 ± 5.6% vs -0.37 ± 4.0%, P = .25). The JP was found to be easier to wear than conventional pumps. The JP is more precise over a short time period, more sensitive to catheter occlusion, well accepted by patients, and consequently, of potential interest for a closed-loop insulin delivery system.

  3. Death by band-aid: fatal misuse of transdermal fentanyl patch.

    Science.gov (United States)

    Bakovic, Marija; Nestic, Marina; Mayer, Davor

    2015-11-01

    We present a case of fatal intoxication by the application of a transdermal fentanyl patch upon a superficial bleeding abrasion of a 2-year-old girl. The grandmother discovered the body of the child in bed at approximately 7 a.m. External examination revealed a properly developed, nourished, and hydrated child, with some vomit in the nostrils and inside the mouth. There was no evidence of trauma besides small contusions and abrasions on the knees, with a patch placed over the largest abrasion. Closer inspection revealed that this was transdermal fentanyl patch. Internal examination and microscopic analysis revealed regurgitation of stomach content, cerebral and pulmonary edema, and liver congestion. Toxicology analysis revealed trace levels of fentanyl in the blood just above the limit of detection (2 ng/mL), while concentrations in the urine, liver, and kidney were approximately 102, 28, and 10 ng/mL, respectively. Investigation discovered that the child injured her knee while playing the evening before. The grandmother applied the patch to cover the injury, unaware that she had used a fentanyl transdermal patch instead of simple band-aid. Although fatal intoxications are uncommon among young children in high-income countries, it is of major interest to raise awareness of such events especially since a great majority of these are preventable. The presented case points at the need for more thorough education of users and more strict rules in prescribing and handling of this potent medicine. As well, we find this case to be a useful contribution to the evaluation of postmortem fentanyl concentrations in fatal intoxication in a small child.

  4. Veritex(TM) Patches for Structural Repair and Re-Use Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Cornerstone Research Group, Inc. (CRG) proposes to develop a bonded composite patch repair and re-use system based on CRG's Veritex

  5. EX1101: Ship Shakedown and Patch Tests on NOAA Ship Okeanos Explorer (EM302)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project will involve the shakedown of all Okeanos Explorer ship capabilities and a patch test of the Kongsberg EM302 multibeam system. Operations for this...

  6. U-Slotted Microstrip Patch Antenna

    Directory of Open Access Journals (Sweden)

    Yogesh Bhomia

    2013-05-01

    Full Text Available A new U–slotted microstrip antenna is proposed. A patch antenna is a narrowband, wide-beam antenna These antennas are low profile, conformal to planar and non-planar surface, simple and inexpensive to manufacture using modern printed circuit technology, mechanically robust when mounted on rigid surface, compatible with MMIC designs and when the particular shape and mode are selected they are very versatile in terms of resonant frequency, polarization, field pattern and impedance. Microstrip antenna consist of a very thin metallic strip (patch placed a small fraction of a wavelength above a ground plane. The patch is generally made of conducting material such as copper or gold and can take any possible shape. This paper presents a design of U - slotted microstrip patch antenna and experimentally studied on IE3D software. This design is achieved by cutting U shape in a patch. With U - slotted shapes patch antenna is designed on a FR4 substrate of thickness 1.524 mm and relative permittivity of 4.4 and mounted above the ground plane at a height of 6 mm. Bandwidth as high as 39% are achieved with stable pattern characteristics, such as gain and cross polarization, within its bandwidth. Impedance bandwidth, antenna gain and return loss are observed for the proposed antenna. Details of the measured and simulated results are presented and discussed

  7. Uniformidade de distribuição superficial e subsuperficial de água e de água residuária de suinocultura com irrigação por aspersão em malha Superficial and subsuperficial distribution uniformity of water and wastewater of swine applied by net-sprinkler irrigation system

    Directory of Open Access Journals (Sweden)

    Luís C. D. Drumond

    2006-08-01

    Full Text Available A irrigação por aspersão em malha está sendo bastante utilizada em café, pastagem, cana forrageira e capineiras, por ser sistema de baixo custo, de fácil instalação e manejo e por permitir fertirrigação com água residuária de suinocultura e de bovinocultura. Para determinar a uniformidade de distribuição de água e de água residuária de suinocultura nesse sistema de irrigação, foi conduzido um experimento na Fazenda-Escola da Universidade de Uberaba, empregando-se pluviômetros eqüidistantes, entre quatro aspersores de duas linhas laterais. O coeficiente de uniformidade de Christiansen (CUC e o coeficiente de uniformidade de distribuição (CUD foram superiores aos valores mínimos recomendados, mesmo com 200 m³ de água residuária de suinocultura por hectare por ano.The net-sprinkler irrigation is frequently being used in coffee, pasture, sugar cane forage and forages, due low cost system, easy installation and handling, allowing fertigation with wastewater of swine and bovine. Aiming to determine the water and wastewater of swine distribution uniformity with this irrigation system, an experiment was carried out at Uberaba University - Brazil, being used pluviometers among four sprinklers of two lateral lines. The Christiansen´s uniformity coefficient (CUC and the uniformity distribution coefficient (UDC were superior to the minimum recommended values, even with 200 m³ ha-1 year-1 of swine wastewater.

  8. Short-term monocular patching boosts the patched eye’s response in visual cortex

    Science.gov (United States)

    Zhou, Jiawei; Baker, Daniel H.; Simard, Mathieu; Saint-Amour, Dave; Hess, Robert F.

    2015-01-01

    Abstract Purpose: Several recent studies have demonstrated that following short-term monocular deprivation in normal adults, the patched eye, rather than the unpatched eye, becomes stronger in subsequent binocular viewing. However, little is known about the site and nature of the underlying processes. In this study, we examine the underlying mechanisms by measuring steady-state visual evoked potentials (SSVEPs) as an index of the neural contrast response in early visual areas. Methods: The experiment consisted of three consecutive stages: a pre-patching EEG recording (14 minutes), a monocular patching stage (2.5 hours) and a post-patching EEG recording (14 minutes; started immediately after the removal of the patch). During the patching stage, a diffuser (transmits light but not pattern) was placed in front of one randomly selected eye. During the EEG recording stage, contrast response functions for each eye were measured. Results: The neural responses from the patched eye increased after the removal of the patch, whilst the responses from the unpatched eye remained the same. Such phenomena occurred under both monocular and dichoptic viewing conditions. Conclusions: We interpret this eye dominance plasticity in adult human visual cortex as homeostatic intrinsic plasticity regulated by an increase of contrast-gain in the patched eye. PMID:26410580

  9. A second defibrillator chest patch electrode will increase implantation rates for nonthoracotomy defibrillators.

    Science.gov (United States)

    Solomon, A J; Swartz, J F; Rodak, D J; Moore, H J; Hannan, R L; Tracy, C M; Fletcher, R D

    1996-09-01

    Nonthoracotomy defibrillator systems can be implanted with a lower morbidity and mortality, compared to epicardial systems. However, implantation may be unsuccessful in up to 15% of patients, using a monophasic waveform. It was the purpose of this study to prospectively examine the efficacy of a second chest patch electrode in a nonthoracotomy defibrillator system. Fourteen patients (mean age 62 +/- 11 years, ejection fraction = 0.29 +/- 0.12) with elevated defibrillation thresholds, defined as > or = 24 J, were studied. The initial lead system consisted of a right ventricular electrode (cathode), a left innominate vein, and subscapular chest patch electrode (anodes). If the initial defibrillation threshold was > or = 24 J, a second chest patch electrode was added. This was placed subcutaneously in the anterior chest (8 cases), or submuscularly in the subscapular space (6 cases). This resulted in a decrease in the system impedance at the defibrillation threshold, from 72.3 +/- 13.3 omega to 52.2 +/- 8.6 omega. Additionally, the defibrillation threshold decreased from > or = 24 J, with a single patch, to 16.6 +/- 2.8 J with two patches. These changes were associated with successful implantation of a nonthoracotomy defibrillator system in all cases. In conclusion, the addition of a second chest patch electrode (using a subscapular approach) will result in lower defibrillation thresholds in patients with high defibrillation thresholds, and will subsequently increase implantation rates for nonthoracotomy defibrillators.

  10. Flexural waves focusing through shunted piezoelectric patches

    Science.gov (United States)

    Yi, K.; Collet, M.; Ichchou, M.; Li, L.

    2016-07-01

    In this paper, we designed and analyzed a piezo-lens to focus flexural waves in thin plates. The piezo-lens is comprised of a host plate and piezoelectric arrays bonded on the surfaces of the plate. The piezoelectric patches are shunted with negative capacitance circuits. The effective refractive indexes inside the piezo-lens are designed to fit a hyperbolic secant distribution by tuning the negative capacitance values. A homogenized model of a piezo-mechanical system is adopted in the designing process of the piezo-lens. The wave focusing effect is studied by the finite element method. Numerical results show that the piezo-lens can focus flexural waves by bending their trajectories, and is effective in a large frequency band. The piezo-lens has the ability to focus flexural waves at different locations by tuning the shunting negative capacitance values. The piezo-lens is shown to be effective for flexural waves generated by different types of sources.

  11. Is Cervical Inlet Patch Important Clinical Problem?

    Science.gov (United States)

    SAHIN, Gurol; ADAS, Gokhan; KOC, Bora; AKCAKAYA, Adem; DOGAN, Yasar; Goksel, Suha; Yalcin, Ozben

    2014-01-01

    AIM: In this study we aim to determine the frequency of Inlet Patch (IP) and its association to clinical symptoms and draw attention to be aware of this heterotopic gastric mucosa. METHODS: This study was a prospective case series that IP was detected in the upper gastrointestinal endoscopy. Patients with laringopharyngeal reflux symptoms underwent endoscopy between March 2009 and July 2012 in two different institutions. All the biopsies were obtained from if there is the IP lesion and antral or/and gastric mucosa. The data was prospectively evaluated. The prevalence was compared with those of patients that did not determine IP in the study period. RESULTS: 3907 upper gastrointestinal system endoscopy was performed while 123 patients consist of 51 male and 72 female was determined as IP. The prevalence of IP in patiens who underwent upper gastrointestinal endoscopy was 3.14% in our study. The majority of symptoms of those who had IP were laringopharyngeal reflux symptoms. Heterotopic gastric mucosa was fixed in 114 cases while 28 chronic inflammation, 9 esophagitis, 5 intestinal metaplasia, 4 glicogenic acanthosis were obtained as additional findings in pathological examinations. CONCLUSION: Heterotopic gastric mucosa in the proximal esophagus is a frequent finding if the endoscopist is aware of this entity. The importance of IP is the increasing number of cases of neoplastic transformation. Symptomatic patients should be treated and should be considered of the complications of heterotopic gastric mucosa. PMID:25018682

  12. UNILATERAL INCOMPLETE SUPERFICIAL PALMAR ARCH: A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Subhankar Chakraborty

    2015-12-01

    Full Text Available The functional importance of hand is revealed by its rich vascularity contributed by superficial and deep palmar arches (SPA and DPA.Superficial palmar arch is located superficial to flexor tendons, and deep palmar arch deep to lumbrical muscles. Variations are found more often in SPA than DPA, later being more or less constant. During routine undergraduate dissection, we observed, unilateral incomplete SPA being formed by superficial palmar branches of ulnar and radial artery in the right hand of a male cadaver. These two arteries remained independent without anastomosis forming incomplete arch (SPA.The superficial branch of ulnar artery entered hand superficial to flexor retinaculum and supplied middle, ring and little finger by three branches. The superficial branch of radial artery via its two branches supplied index finger and thumb. Classical SPA formation was seen on left side. The presence of an incomplete SPA as in this case is a potential danger in RA harvesting for CABG.Variations in SPA play a pivotal role in microvascular surgical procedures of hand, RAinterventions and arterial graft applications.

  13. In vivo patch clamp recording technique in the study of neurophysiology

    Institute of Scientific and Technical Information of China (English)

    Lan-Wei CUI; Yu-Rong LI

    2006-01-01

    The patch clamp recording technique in vivois a blind patch clamp recording methods to record the current of the spinal or cereral neurons of anaesthesia ( or awake) animals. This technique can be used to study the synaptic function and plasticity in central nervous system in vivoin order to understand the physiological properties of the ion channels from an integrated point of view. The advantage of this technique have already presented itself in the study of the synaptic transmission and nervous network. Nowadays, in vivo patch whole-cell recording technique in combination with other techniques is becoming a common method in the research fields.

  14. Individual colour patches as multicomponent signals.

    Science.gov (United States)

    Grether, Gregory F; Kolluru, Gita R; Nersissian, Karen

    2004-08-01

    Colour patches are complex traits, the components of which may evolve independently through a variety of mechanisms. Although usually treated as simple, two-dimensional characters and classified as either structural or pigmentary, in reality colour patches are complicated, three-dimensional structures that often contain multiple pigment types and structural features. The basic dermal chromatophore unit of fishes, reptiles and amphibians consists of three contiguous cell layers. Xanthophores and erythrophores in the outermost layer contain carotenoid and pteridine pigments that absorb short-wave light; iridophores in the middle layer contain crystalline platelets that reflect light back through the xanthophores; and melanophores in the basal layer contain melanins that absorb light across the spectrum. Changes in any one component of a chromatophore unit can drastically alter the reflectance spectrum produced, and for any given adaptive outcome (e.g. an increase in visibility), there may be multiple biochemical or cellular routes that evolution could take, allowing for divergent responses by different populations or species to similar selection regimes. All of the mechanisms of signal evolution that previously have been applied to single ornaments (including whole colour patches) could potentially be applied to the individual components of colour patches. To reach a complete understanding of colour patch evolution, however, it may be necessary to take an explicitly multi-trait approach. Here, we review multiple trait evolution theory and the basic mechanisms of colour production in fishes, reptiles and amphibians, and use a combination of computer simulations and empirical examples to show how multiple trait evolution theory can be applied to the components of single colour patches. This integrative perspective on animal colouration opens up a host of new questions and hypotheses. We offer specific, testable functional hypotheses for the most common pigmentary

  15. Prevalence of superficial siderosis following singular, acute aneurysmal subarachnoid hemorrhage

    Energy Technology Data Exchange (ETDEWEB)

    Lummel, N.; Bochmann, K. [Ludwig-Maximilian-University, Department of Neuroradiology, Klinikum Grosshadern, Munich (Germany); Bernau, C. [Leibniz-Rechenzentrum, Munich (Germany); Thon, N. [Ludwig-Maximilian-University, Department of Neurosurgery, Klinikum Grosshadern, Munich (Germany); Linn, J. [Technical University, Department of Neuroradiology, Klinikum Dresden, Dresden (Germany)

    2015-04-01

    Superficial siderosis is presumably a consequence of recurrent bleeding into the subarachnoid space. The objective of this study was to assess the prevalence of superficial siderosis after singular, aneurysmal subarachnoid hemorrhage (SAH) in the long term. We retrospectively identified all patients who presented with a singular, acute, aneurysmal SAH at our institution between 2010 and 2013 and in whom a magnetic resonance imaging (MRI) including T2*-weighted imaging was available at least 4 months after the acute bleeding event. MRI scans were judged concerning the presence and distribution of superficial siderosis. Influence of clinical data, Fisher grade, localization, and cause of SAH as well as the impact of neurosurgical interventions on the occurrence of superficial siderosis was tested. Seventy-two patients with a total of 117 MRIs were included. Mean delay between SAH and the last available MRI was 47.4 months (range 4-129). SAH was Fisher grade 1 in 2 cases, 2 in 4 cases, 3 in 10 cases, and 4 in 56 cases. Superficial siderosis was detected in 39 patients (54.2 %). In all patients with more than one MRI scan, localization and distribution of superficial siderosis did not change over time. Older age (p = 0.02) and higher degree of SAH (p = 0.03) were significantly associated with the development of superficial siderosis. Superficial siderosis develops in approximately half of patients after singular, aneurysmal SAH and might be more common in patients with an older age and a greater amount of blood. However, additional factors must play a role in whether a patient is prone to develop superficial siderosis or not. (orig.)

  16. Comportamiento hidráulico de los sistemas de riego por goteo superficial y sub superficial

    OpenAIRE

    2011-01-01

    Para su evaluación el sistema de riego fue montado con un diseño experimental completamente aleatorizado, con cuatro tratamientos, uno con el sistema de riego por goteo superficial y tres con sistemas de riego por goteo sub superficiales con emisores soterrados a 15, 30 y 45 centímetros de profundidad. Se realizaron evaluaciones de laboratorio y de campo de los principales parámetros hidráulicos del sistema, al inicio de la primera campaña de riego y al final de la tercera, obteniéndose en el...

  17. Gigaseal formation in patch clamping with applications of nanotechnology

    CERN Document Server

    Malboubi, Majid

    2014-01-01

    This book presents an investigation of gigaseal formation using micro/nanotechnology. The aims of the book are twofold. First, it explains the mechanisms of gigaseal formation using the latest discoveries. Second, it provides practical techniques for frequent formation of high resistance seals. The formation of a high-resistance electrical seal, also known as a gigaseal, between a cell membrane and a glass micropipette tip is essential in patch-clamp experiments. Even though four decades have passed since the introduction of the patch-clamping technique by Neher and Sakmann, gigaseal formation remains an obstacle in developing the high-throughput ion channel screening systems required by the pharmaceutical industry. Here the authors share their latest methods for achieving gigaseal formation and describe techniques that are highly desirable at both research and industrial levels. Nanotechnology has been found to be a powerful tool for studying and modifying glass micropipettes and in tackling the problem of g...

  18. A patch in the pectoral position lowers defibrillation threshold.

    Science.gov (United States)

    Karasik, P; Solomon, A; Verdino, R; Moore, H; Rodak, D; Hannan, R; Fletcher, R

    1997-06-01

    Implantable pacemaker cardioverter defibrillators are now available with biphasic waveforms, which have been shown to markedly improve defibrillation thresholds (DFTs). However, in a number of patients the DFT remains high. Also, DFT may increase after implantation, especially if antiarrhythmic drugs are added. We report on the use of a subcutaneous patch in the pectoral position in 15 patients receiving a transvenous defibrillator as a method of easily reducing the DFT. A 660-mm2 patch electrode was placed beneath the generator in a pocket created on the pectoral fascia. The energy required for defibrillation was lowered by 56% on average, and the system impedance was lowered by a mean of 25%. This maneuver allowed all patients to undergo a successful implant with adequate safety margin.

  19. A "Patch" to the NYU Emergency Department Visit Algorithm.

    Science.gov (United States)

    Johnston, Kenton J; Allen, Lindsay; Melanson, Taylor A; Pitts, Stephen R

    2017-08-01

    To document erosion in the New York University Emergency Department (ED) visit algorithm's capability to classify ED visits and to provide a "patch" to the algorithm. The Nationwide Emergency Department Sample. We used bivariate models to assess whether the percentage of visits unclassifiable by the algorithm increased due to annual changes to ICD-9 diagnosis codes. We updated the algorithm with ICD-9 and ICD-10 codes added since 2001. The percentage of unclassifiable visits increased from 11.2 percent in 2006 to 15.5 percent in 2012 (p < .01), because of new diagnosis codes. Our update improves the classification rate by 43 percent in 2012 (p < .01). Our patch significantly improves the precision and usefulness of the most commonly used ED visit classification system in health services research. © Health Research and Educational Trust.

  20. Superficial cervicovaginal myofibroblastoma: report of four cases and literature review

    Institute of Scientific and Technical Information of China (English)

    WANG Qi-feng; WU Yu-yu; WANG Jian

    2010-01-01

    @@ In 2001, Laskin et al~1 firstly described a series of 14 seemly distinctive mesenchymal tumors that occurred exclusively in the superficial lamina propria of the vagina and cervix of middle to old-aged women. They proposed the term "superficial cervicovaginal myofibroblastoma (SCVM)" to highlight the unique features of this tumor: the superficial subepithelial location and myofibroblastic differentiation of the tumor cells. SCVM appears less well recognized with only three additional reports have been documented in the English literatures.~(2-4) In this study, we described four new cases of SCVM to further characterize the clinical and pathological features of this rare entity.

  1. Superficial Fibromatosis Mimicking Glomus Tumor of the Second Toe.

    Science.gov (United States)

    Jo, Hyang Jeong; Chae, Soo Uk; Kim, Gang Deuk; Kim, Yeung Jin; Choi, Deok Hwa; Park, Jae In

    2015-09-01

    Various types of tumor can occur in the subungual space, including glomus tumors, subungual exostosis, hemangioma, epidermal cysts, and malignant tumors. While fibromatosis can occur at various sites throughout the body, it is very rarely seen in the toe. Here, we are the first to report a case of superficial fibromatosis mimicking a glomus tumor in the subungual space of the second toe. The presentation of this condition shows the possibility of encountering uncommon superficial fibromatosis in the distal phalanx of the toe, and suggests that superficial fibromatosis should be included in the differential diagnosis of a glomus tumor in the toe.

  2. Revisión sobre modelado de superficies complejas

    Directory of Open Access Journals (Sweden)

    Juan D. Osorio

    2004-01-01

    Full Text Available Este artículo presenta una revisión de las técnicas más empleadas para la obtención de modelos computacionales de superficies complejas. Estas representaciones están siendo utilizadas en diversas áreas de la industria mediante procedimientos de ingeniería reversa. Las tres principales categorías son las superficies funcionales (implícitas, paramétricas y las superficies complejas simplicial (mallas triangulares. Se realiza un paralelo entre estos métodos y se exponen las ventajas y las desventajas de cada una de estas representaciones.

  3. A Dynamic Decision Support System for Farm Water Management in Surface Irrigation: Model Development and Application Un Sistema de Soporte Dinámico de Decisión para la Gestión de Agua Predial en Riego Superficial: Desarrollo y Aplicación del Modelo

    Directory of Open Access Journals (Sweden)

    Carlos I. Flores

    2010-06-01

    Full Text Available An online dynamic decision support system (DDSS was developed, to support the farm water management in surface irrigation. The online DDSS was based on the formulation and integration of three components: a dynamic-relational data base, an administrator model, and a graphical user interface. The DDSS allows routines of actualization, edition and addition of online data, providing information in real time. The online DDSS was applied in an orange orchard (Citrus sinensis L. Osbeck cv. Valencia Late under furrow irrigation. The results pointed out that the time irrigation cutoff was the main significant management factor, to decrease the hazard of leaching, superficial runoff and percolation. Applying the results obtained with the DDSS, furrow irrigation efficiencies could be improved up to values equals to 95.89% for application efficiency and 94.61% for total distribution efficiency. As a conclusion, the DDSS demonstrated to be a useful tool to assist the decision making process, providing proper information for the management of the available water resource at farm level.Se desarrolló un sistema de soporte dinámico de decisión (SSDD en línea, con el objetivo de asistir la gestión del agua predial en riego superficial. El SSDD en línea se basó en la formulación e integración de tres componentes: una base de datos relacional dinámica, un modelo administrador y una interfaz gráfica de usuario. El SSDD permite rutinas de actualización, edición y adición de información en línea, proporcionando información en tiempo real. El SSDD en línea se aplicó en un huerto de naranjos (Citrus sinensis L. Osbeck cv. Valencia Late bajo riego por surcos. Los resultados indicaron que el tiempo de corte es la variable significativa de decisión para disminuir el riesgo de lixiviación, escorrentía superficial y percolación. Aplicando los resultados obtenidos con el SSDD, las eficiencias del riego por surco podrían mejorarse, alcanzando valores

  4. Antibody conjugate radioimmunotherapy of superficial bladder cancer

    Directory of Open Access Journals (Sweden)

    Alan Perkins

    2002-09-01

    Full Text Available The administration of antibody conjugates for cancer therapy is now proving to be of clinical value. We are currently undertaking a programme of clinical studies using the monoclonal antibody C595 (IgG3 which reacts with the MUC1 glycoprotein antigen that is aberrantly expressed in a high proportion of bladder tumours. Radioimmunoconjugates of the C595 antibody have been produced with high radiolabelling efficiency and immunoreactivity using Tc-99m and In-111 for diagnostic imaging, and disease staging and the cytotoxic radionuclides Cu-67 and Re-188 for therapy of superficial bladder cancer. A Phase I/II therapeutic trail involving the intravesical administration of antibody directly into the bladder has now begun.A administração de anticorpos conjugados para o tratamento do câncer está agora provando ser de valor clínico. Nós estamos atualmente realizando um programa de estudos clínicos usando o anticorpo monoclonal C595 (IgG3 que reage com a glicoproteína MUC1 que está aberrantemente expressa numa alta proporção de tumores de bexiga. Tem sido produzidos radioimunoconjugados do anticorpo C595, com alta eficiência de radiomarcação e a imunoreatividade, usando-se o Tc-99m e In-111, para o diagnóstico por imagem e estagiamento de doenças. Tem sido produzidos, também, radionuclídeos citotóxicos (Cu-67 e Re-188 para o tratamento de cânceres superficiais de bexiga. A fase terapêutica I/II já se iniciou, envolvendo a administração intravesical do anticorpo diretamente na bexiga.

  5. Hemipelvic irradiation for superficial bladder cancer

    Energy Technology Data Exchange (ETDEWEB)

    Tashiro, Kazuya; Machida, Toyohei; Ooishi, Yukihiko; Ueda, Masataka; Kido, Akira; Wada, Tetsuro; Yoshigoe, Fukuo; Yamashita, Takashi; Mochizuki, Sachio

    1985-02-01

    In 15 patients with superficial bladder cancer hemipelvic irradiation was performed for prevention of relapse of cancer and decrease in side effects with following results. All patients received TUR-Bt at our department during the six years period from 1978 to 1983. As to stages, one was classified as Ta, 11 as T 1 and 3 as T 2, and pathologic diagnosis was transitional epithelial carcinoma of grade 1 in 1 case, grade 2 in 8 cases and grade 3 in 6 cases. Irradiation was started from the 7 th to 14 th day after TUR-Bt. At first, hemipelvic anterior and posterior field including the field from the affected pelvis to 1 to 2 cm beyond the midline toward the contralateral side and from the aortic bifurcation to the prostatic urethra were irradiated at a dose of 45 Gy. Then, whole bladder field was given an additional rotation irradiation of 20 Gy. The mean observation period was 43 months (ranging from 12 to 79 months) and relapse of cancer was observed in 6 cases out of 15 cases (40%). The site of relapse was in the irradiated site in 2 cases, contralateral site in 3 cases and both side in 1 cases. However, in all of the relapsed cases no aggravation in differential degree or progression in stage was observed. As the side effects, radiation cystitis developed as a delayed damage in 1 case. Thus, although no efficacy for prevention of relapse which we had expected was not seen, this irradiation method effectively inhibited the progression of lesion and development of delayed damage. (author).

  6. Deformation of vortex patches by boundaries

    CERN Document Server

    Crosby, A; Morrison, P J

    2013-01-01

    The deformation of two-dimensional vortex patches in the vicinity of fluid boundaries is investigated. The presence of a boundary causes an initially circular patch of uniform vorticity to deform. Sufficiently far away from the boundary, the deformed shape is well approximated by an ellipse. This leading order elliptical deformation is investigated via the elliptic moment model of Melander, Zabusky & Styczek [M. V. Melander, N. J. Zabusky & A. S. Styczek, J. Fluid. Mech., 167, 95 (1986)]. When the boundary is straight, the centre of the elliptic patch remains at a constant distance from the boundary, and the motion is integrable. Furthermore, since the straining flow acting on the patch is constant in time, the problem is that of an elliptic vortex patch in constant strain, which was analysed by Kida [S. Kida, J. Phys. Soc. Japan, 50, 3517 (1981)]. For more complicated boundary shapes, such as a square corner, the motion is no longer integrable. Instead, there is an adiabatic invariant for the motion....

  7. Measles vaccination using a microneedle patch.

    Science.gov (United States)

    Edens, Chris; Collins, Marcus L; Ayers, Jessica; Rota, Paul A; Prausnitz, Mark R

    2013-07-25

    Measles vaccination programs would benefit from delivery methods that decrease cost, simplify logistics, and increase safety. Conventional subcutaneous injection is limited by the need for skilled healthcare professionals to reconstitute and administer injections, and by the need for safe needle handling and disposal to reduce the risk of disease transmission through needle re-use and needlestick injury. Microneedles are micron-scale, solid needles coated with a dry formulation of vaccine that dissolves in the skin within minutes after patch application. By avoiding the use of hypodermic needles, vaccination using a microneedle patch could be carried out by minimally trained personnel with reduced risk of blood-borne disease transmission. The goal of this study was to evaluate measles vaccination using a microneedle patch to address some of the limitations of subcutaneous injection. Viability of vaccine virus dried onto a microneedle patch was stabilized by incorporation of the sugar, trehalose, and loss of viral titer was less than 1 log10(TCID50) after storage for at least 30 days at room temperature. Microneedle patches were then used to immunize cotton rats with the Edmonston-Zagreb measles vaccine strain. Vaccination using microneedles at doses equaling the standard human dose or one-fifth the human dose generated neutralizing antibody levels equivalent to those of a subcutaneous immunization at the same dose. These results show that measles vaccine can be stabilized on microneedles and that vaccine efficiently reconstitutes in vivo to generate a neutralizing antibody response equivalent to that generated by subcutaneous injection.

  8. Characterizing the morphology of protein binding patches.

    Science.gov (United States)

    Malod-Dognin, Noël; Bansal, Achin; Cazals, Frédéric

    2012-12-01

    Let the patch of a partner in a protein complex be the collection of atoms accounting for the interaction. To improve our understanding of the structure-function relationship, we present a patch model decoupling the topological and geometric properties. While the geometry is classically encoded by the atomic positions, the topology is recorded in a graph encoding the relative position of concentric shells partitioning the interface atoms. The topological-geometric duality provides the basis of a generic dynamic programming-based algorithm comparing patches at the shell level, which may favor topological or geometric features. On the biological side, we address four questions, using 249 cocrystallized heterodimers organized in biological families. First, we dissect the morphology of binding patches and show that Nature enjoyed the topological and geometric degrees of freedom independently while retaining a finite set of qualitatively distinct topological signatures. Second, we argue that our shell-based comparison is effective to perform atomic-level comparisons and show that topological similarity is a less stringent than geometric similarity. We also use the topological versus geometric duality to exhibit topo-rigid patches, whose topology (but not geometry) remains stable upon docking. Third, we use our comparison algorithms to infer specificity-related information amidst a database of complexes. Finally, we exhibit a descriptor outperforming its contenders to predict the binding affinities of the affinity benchmark. The softwares developed with this article are availablefrom http://team.inria.fr/abs/vorpatch_compatch/.

  9. Microneedle patches for vaccination in developing countries.

    Science.gov (United States)

    Arya, Jaya; Prausnitz, Mark R

    2016-10-28

    Millions of people die of infectious diseases each year, mostly in developing countries, which could largely be prevented by the use of vaccines. While immunization rates have risen since the introduction of the Expanded Program on Immunization (EPI), there remain major challenges to more effective vaccination in developing countries. As a possible solution, microneedle patches containing an array of micron-sized needles on an adhesive backing have been developed to be used for vaccine delivery to the skin. These microneedle patches can be easily and painlessly applied by pressing against the skin and, in some designs, do not leave behind sharps waste. The patches are single-dose, do not require reconstitution, are easy to administer, have reduced size to simplify storage, transportation and waste disposal, and offer the possibility of improved vaccine immunogenicity, dose sparing and thermostability. This review summarizes vaccination challenges in developing countries and discusses advantages that microneedle patches offer for vaccination to address these challenges. We conclude that microneedle patches offer a powerful new technology that can enable more effective vaccination in developing countries. Copyright © 2015. Published by Elsevier B.V.

  10. Dermoscopy of shagreen patch: A first report

    Directory of Open Access Journals (Sweden)

    Shivanand Gundalli

    2015-07-01

    Full Text Available The name is derived from French phrase peau chagrinee which is usually found on lower back, buttock and thigh. The major manifestations of Tuberous sclerosis include skin lesions in more than 95%, mental retardation in approximately 50%, autism, seizures in approximately 85%. The incidence at birth is estimated to be 1 in 5800. We report case of shagreen patch in a 27 year female which is present since birth. However there is no history of seizures or consanginous marriage in our case. Associated features are naevus comedonicus and naevus collagenosis, facial angiofibroma. Shagreen patch are present in mandibular area of face. Although, diagnosis is easy, it can be mistaken for inflammatory verrucous epidermal nevus, plaques of other inflammatory skin conditions. Diagnosis is usually on clinical background. Sometimes biopsy is necessary to confirm the diagnosis. Dermoscopy, a non-invasive, in vivo technique for the microscopic examination of pigmented skin lesions, has the potential to improve the diagnostic accuracy. Dermoscopy of Shagreen patch showed reddish-brown strands with white dots giving a cobblestone appearance It can be utilized as a diagnostic aide in the diagnosis of Shagreen patch. Authors evaluated the dermoscopic patterns of Shagreen patch and hence, it is useful in diagnosis.

  11. SuperPatchMatch: an Algorithm for Robust Correspondences using Superpixel Patches.

    Science.gov (United States)

    Giraud, Remi; Ta, Vinh-Thong; Bugeau, Aurelie; Coupe, Pierrik; Papadakis, Nicolas

    2017-05-29

    Superpixels have become very popular in many computer vision applications. Nevertheless, they remain underexploited since the superpixel decomposition may produce irregular and non stable segmentation results due to the dependency to the image content. In this paper, we first introduce a novel structure, a superpixel-based patch, called SuperPatch. The proposed structure, based on superpixel neighborhood, leads to a robust descriptor since spatial information is naturally included. The generalization of the PatchMatch method to SuperPatches, named SuperPatchMatch, is introduced. Finally, we propose a framework to perform fast segmentation and labeling from an image database, and demonstrate the potential of our approach since we outperform, in terms of computational cost and accuracy, the results of state-of-the-art methods on both face labeling and medical image segmentation.

  12. The effects of patch shape and connectivity on nest site selection and reproductive success of the Indigo Bunting.

    Energy Technology Data Exchange (ETDEWEB)

    Weldon, Aimee Jean

    2004-07-01

    Description – Ph.D Dissertation. North Carolina State University. Raleigh, North Carolina. 135 pp. Abatract - Habitat fragmentation and its associated effects have been blamed for the recent population declines of many Neotropical migratory bird species. Increased predation and parasitism resulting from edge-related effects have been implicated for poor nesting success in many studies, mostly of forest interior species. However, little attention has been devoted to disturbance-dependent birds. In this study, I examine how patch shape and connectivity in fragmented landscapes affects the reproductive success of disturbance-dependent bird species, specifically the Indigo Bunting (Passerina cyanea). I conducted my study in a landscape-scale experimental system of similar-area habitat patches that differed in connectivity and in shape. Shapes differed between edgy and rectangular forms, where edgy patches contained 50% more edge than rectangular patches. I tested whether edgy patches function as ecological traps for species with strong edge preferences, by leading them to select dangerous habitats. Indigo Buntings preferentially selected edgy patches over rectangular patches, but experienced significantly lower reproductive success in edgy patches early in the season. Although predation pressure intensified in rectangular patches late in the season, seasonal fecundity was still significantly lower in edgy patches, providing the first empirical evidence that edges can function as ecological traps for Indigo Buntings. A second objective of my study was to evaluate the efficacy of conservation corridors for disturbance-dependent bird species. Conservation corridors have become a popular strategy to preserve biodiversity and promote gene flow in fragmented landscapes, but corridors may also have negative consequences. I tested the hypothesis that corridors can increase nest predation risk in connected patches relative to unconnected patches. Nest predation rates

  13. A stronger patch test elicitation reaction to the allergen hydroxycitronellal plus the irritant sodium lauryl sulfate

    DEFF Research Database (Denmark)

    Heydorn, S; Andersen, Klaus Ejner; Johansen, Jeanne Duus;

    2003-01-01

    elicitation reaction than patch testing with the allergen (hydroxycitronellal) alone, in patients previously patch tested positive to hydroxycitronellal. A stronger patch test elicitation reaction was defined as at least 1 day of patch test reading showing more positive patch tests...

  14. Fault-patch stress-transfer efficiency in presence of sub-patch geometric complexity

    KAUST Repository

    Zielke, Olaf

    2015-04-01

    It is well known that faults are not planar surfaces. Instead they exhibit self-similar or self-affine properties that span a wide range of spatial (sub-micrometer to tens-of-kilometer). This geometric fault roughness has a distinct impact on amount and distribution of stresses/strains induced in the medium and on other portions of the fault. However, when numerically simulated (for example in multi-cycle EQ rupture simulations or Coulomb failure stress calculations) this roughness is largely ignored: individual fault patches --the incremental elements that build the fault surface in the respective computer models-- are planar and fault roughness at this and lower spatial scales is not considered. As a result, the fault-patch stress-transfer efficiency may be systematically too large in those numerical simulations with respect to the "actual" efficiency level. Here, we investigate the effect of sub-patch geometric complexity on fault-patch stress-transfer efficiency. For that, we sub-divide a fault patch (e.g., 1x1km) into a large number of sub-patches (e.g., 20x20m) and determine amount of induced stresses at selected positions around that patch for different levels and realizations of fault roughness. For each fault roughness level, we compute mean and standard deviation of the induced stresses, enabling us to compute the coefficient of variation. We normalize those values with stresses from the corresponding single (planar) fault patch, providing scaling factors and their variability for stress transfer efficiency. Given a certain fault roughness that is assumed for a fault, this work provides the means to implement the sub-patch fault roughness into investigations based on fault-patch interaction schemes.

  15. Patch-augmented rotator cuff repair: influence of the patch fixation technique on primary biomechanical stability.

    Science.gov (United States)

    Jung, Christian; Spreiter, Gregor; Audigé, Laurent; Ferguson, Stephen J; Flury, Matthias

    2016-05-01

    There is an ongoing debate about the potential of patch augmentation to improve biomechanical stability and healing associated with rotator cuff repair. The biomechanical properties of three different patch-augmented rotator cuff repair techniques were assessed in vitro and compared with a standard repair. Dermal collagen patch augmentation may increase the primary stability and strength of the repaired tendon in vitro, depending on the technique used for patch application. Forty cadaveric sheep shoulders with dissected infraspinatus tendons were randomized into four groups (n = 10/group) for tendon repair using a knotless double-row suture anchor technique. A xenologous dermal extracellular matrix patch was used for augmentation in the three test groups using an "integrated", "cover", or "hybrid" technique. Tendons were preconditioned, cyclically loaded from 10 to 30 N at 1 Hz, and then loaded monotonically to failure. Biomechanical properties and the mode of failure were evaluated. Patch augmentation significantly increased the maximum load at failure by 61 % in the "cover" technique test group (225.8 N) and 51 % in the "hybrid" technique test group (211.4 N) compared with the non-augmented control group (140.2 N) (P ≤ 0.015). For the test group with "integrated" patch augmentation, the load at failure was 28 % lower (101.6 N) compared with the control group (P = 0.043). There was no significant difference in initial and linear stiffness among the four experimental groups. The most common mode of failure was tendon pullout. No anchor dislocation, patch disruption or knot breakage was observed. Additional patch augmentation with a collagen patch influences the biomechanical properties of a rotator cuff repair in a cadaveric sheep model. Primary repair stability can be significantly improved depending on the augmentation technique.

  16. Argus II retinal prosthesis implantation with scleral flap and autogenous temporalis fascia as alternative patch graft material: a 4-year follow-up

    Science.gov (United States)

    Matet, Alexandre; Amar, Nawel; Mohand-Said, Saddek; Sahel, José-Alain; Barale, Pierre-Olivier

    2016-01-01

    Introduction The Argus II retinal prosthesis is composed of an epiretinal electrode array positioned over the macula and connected to an extrascleral electronics case via a silicone cable, running through a sclerotomy. During implantation, the manufacturer recommends to cover the sclerotomy site with a patch of processed human pericardium to prevent postoperative hypotony and conjunctival erosion by the underlying electronics case. Due to biomedical regulations prohibiting the use of this material in France, we developed an alternative technique combining a scleral flap protecting the sclerotomy and an autogenous graft of superior temporalis fascia overlying the electronics case. Methods The purpose of this study is to describe the 4-year outcomes of this modified procedure in three subjects who underwent Argus II Retinal Prosthesis System implantation. Clinical data consisting of intraocular pressure measurements and tolerance in terms of conjunctival erosion or inflammation were retrospectively assessed over a 4-year postoperative follow-up. Results None of the three patients implanted with the modified technique developed ocular hypotony over 4 years. A normal, transient conjunctival inflammation occurred during the first postoperative month but conjunctival erosion was not observed in any of the three patients over 4 years. Four years after implantation, the autogenous temporalis fascia graft remained well tolerated and the retinal prosthesis was functional in all three patients. Conclusion The combination of an autograft of superficial temporalis fascia and a scleral flap efficiently prevented leakage through the sclerotomy site, ocular hypotony, and conjunctival erosion by the extrascleral electronics case. This modified technique is suitable for the implantation of existing and forthcoming retinal prostheses. Superficial temporalis fascia may also be used as alternative to commercial tectonic tissues for scleral wound repair in clinical settings where they

  17. Patch Clamp: A Powerful Technique for Studying the Mechanism of Acupuncture

    Directory of Open Access Journals (Sweden)

    D. Zhang

    2012-01-01

    Full Text Available Cellular and molecular events can be investigated using electrophysiological techniques. In particular, the patch-clamp method provides detailed information. In addition, the patch-clamp technique has become a powerful method for investigating the mechanisms underlying the effects of acupuncture. In this paper, recent researches on how acupuncture might modulate electrophysiological responses in the central nervous system (CNS and affect peripheral structures are reviewed.

  18. Mesenchymal progenitor cells derived from synovium and infrapatellar fat pad as a source for superficial zone cartilage tissue engineering: analysis of superficial zone protein/lubricin expression.

    Science.gov (United States)

    Lee, Sang Yang; Nakagawa, Toshiyuki; Reddi, A Hari

    2010-01-01

    Superficial zone protein (SZP) is a boundary lubricant of articular cartilage in joints. As SZP at the surface of articular cartilage plays an important role in the normal function of synovial joints, the localization of SZP-secreting cells at the surface of tissue-engineered cartilage is prerequisite. The aim of this study was to identify suitable progenitor cell sources for tissue engineering of superficial zone cartilage. We investigated whether mesenchymal progenitor cells (MPCs) from synovium and infrapatellar fat pad (IFP) have the potential for secretion of SZP after chondrogenic differentiation in an aggregate pellet culture system. SZP was immunolocalized in pellets from synovium-MPCs and IFP-MPCs. The enzyme-linked immunosorbent assay analysis of SZP demonstrated that chondrogenically differentiated synovium-MPC and IFP-MPC pellets secreted SZP into media. Real-time polymerase chain reaction analysis showed significant upregulation of SZP mRNA in synovium-MPC and IFP-MPC pellets after chondrogenic differentiation. The synovium-MPCs demonstrated the higher colony-forming, proliferative, and chondrogenic potential, and exhibited greater SZP secretion after chondrogenic induction compared with IFP-MPCs. In conclusion, both synovium and IFP are promising cell sources for tissue engineering of superficial zone cartilage.

  19. Boolean Operations with Prism Algebraic Patches

    Science.gov (United States)

    Bajaj, Chandrajit; Paoluzzi, Alberto; Portuesi, Simone; Lei, Na; Zhao, Wenqi

    2009-01-01

    In this paper we discuss a symbolic-numeric algorithm for Boolean operations, closed in the algebra of curved polyhedra whose boundary is triangulated with algebraic patches (A-patches). This approach uses a linear polyhedron as a first approximation of both the arguments and the result. On each triangle of a boundary representation of such linear approximation, a piecewise cubic algebraic interpolant is built, using a C1-continuous prism algebraic patch (prism A-patch) that interpolates the three triangle vertices, with given normal vectors. The boundary representation only stores the vertices of the initial triangulation and their external vertex normals. In order to represent also flat and/or sharp local features, the corresponding normal-per-face and/or normal-per-edge may be also given, respectively. The topology is described by storing, for each curved triangle, the two triples of pointers to incident vertices and to adjacent triangles. For each triangle, a scaffolding prism is built, produced by its extreme vertices and normals, which provides a containment volume for the curved interpolating A-patch. When looking for the result of a regularized Boolean operation, the 0-set of a tri-variate polynomial within each such prism is generated, and intersected with the analogous 0-sets of the other curved polyhedron, when two prisms have non-empty intersection. The intersection curves of the boundaries are traced and used to decompose each boundary into the 3 standard classes of subpatches, denoted in, out and on. While tracing the intersection curves, the locally refined triangulation of intersecting patches is produced, and added to the boundary representation. PMID:21516262

  20. FORMULATION AND EVALUATION OF CARVEDILOL TRANSDERMAL PATCHES

    Directory of Open Access Journals (Sweden)

    Mandal Sonjoy

    2011-01-01

    Full Text Available The present study was carried out to develop and evaluate matrix-type transdermal formulations containing carvedilol with different ratios of hydrophilic (HPMC and hydrophobic polymeric (Eudragit RS100 combinations plasticized with glycerin and dibutyl pthalate by the solvent evaporation technique. Effect of surfactant (PEG-400 and Tween 80 and permeation enhancers (DMSO and DMF were studied. The interference of the polymers were ruled out by infrared and uv spectroscopic methods. Viscosity of the polymers was determined using Brookfield viscometer (LVDV-E. The partition coefficient study was performed using n-octanol as the organic phase and phosphate buffer pH 7.4 as an aqueous phase. The prepared patches were tested for their physicochemical characteristics such as thickness, weight, and drug content uniformity, swelling index, water vapour transmission, folding endurance, and tensile strength. In vitro release studies of carvedilol-loaded patches in phosphate buffer (pH, 7.4 exhibited drug release in the range of 80.70 to 98.56 % in 24 h. Data of in vitro release from patches were fit in to different equations and kinetic models to explain release kinetics. The models used were zero and first-order equations, Hixon-Crowell, Higuchi and Korsmeyer-Peppas models. Based on physicochemical and in vitro release studies, patches containing HPMC and Eudragit RS 100 (DMSO as permeation enhancer were chosen for in vitro skin permeation studies which were performed using a modified diffusion cell across rat abdominal skin and showed first order release mechanism. Skin studies for the transdermal patches were assessed and were found to be free of irritation. The patches were subjected to short term stability studies and were found stable. Good correlation was observed (R2 = 0.810 with in vitro release Vs in vitro skin permeation studies.

  1. Superficial Radiation Therapy for the Treatment of Nonmelanoma Skin Cancers.

    Science.gov (United States)

    McGregor, Sean; Minni, John; Herold, David

    2015-12-01

    Superficial radiation therapy has become more widely available to dermatologists. With the advent of more portable machines, it has become more convenient for dermatology practices to employ in an office-based setting. The goal of this paper is to provide a deeper insight into the role of superficial radiation therapy in dermatology practice and to review the current literature surrounding its use in the treatment of both basal and squamous cell carcinomas.

  2. Functional Compartmentalization of the Human Superficial Masseter Muscle

    OpenAIRE

    Guzmán-Venegas, Rodrigo A.; Biotti Picand, Jorge L.; Francisco J Berral de la Rosa

    2015-01-01

    Some muscles have demonstrated a differential recruitment of their motor units in relation to their location and the nature of the motor task performed; this involves functional compartmentalization. There is little evidence that demonstrates the presence of a compartmentalization of the superficial masseter muscle during biting. The aim of this study was to describe the topographic distribution of the activity of the superficial masseter (SM) muscle's motor units using high-density surface e...

  3. Patch testing for adverse drug reactions.

    Science.gov (United States)

    Sekhon, Sahil; Nedorost, Susan T

    2017-01-01

    Adverse drug reactions result in a substantial number of hospital admissions and inpatient events. Diagnosis usually is made with clinical judgment and circumstantiality without diagnostic testing. Furthermore, even in situations where diagnostic testing is performed, no safe gold standard tests exist. Oral rechallenge is currently the gold standard but carries the risk of recrudescence of severe allergic symptoms. Other tests include skin prick tests, the lymphocyte transformation test, immunohistochemistry, and patch testing. This article provides a review of patch testing in cases of adverse drug reactions and presents new data on this topic.

  4. Assembling a Network out of Ambiguous Patches

    OpenAIRE

    Yartseva, Lyudmila; Elbert, Jefferson Simoes; Grossglauser, Matthias

    2016-01-01

    Many graph mining and network analysis problems rely on the availability of the full network over a set of nodes. But inferring a full network is sometimes non-trivial if the raw data is in the form of many small {\\em patches} or subgraphs, of the true network, and if there are ambiguities in the identities of nodes or edges in these patches. This may happen because of noise or because of the nature of data; for instance, in social networks, names are typically not unique. \\textit{Graph...

  5. Learning Dictionaries of Discriminative Image Patches

    DEFF Research Database (Denmark)

    Dahl, Anders Lindbjerg; Larsen, Rasmus

    2011-01-01

    Remarkable results have been obtained using image models based on image patches, for example sparse generative models for image inpainting, noise reduction and superresolution, sparse texture segmentation or texton models. In this paper we propose a powerful and yet simple approach for segmentation...... using dictionaries of image patches with associated label data. The approach is based on ideas from sparse generative image models and texton based texture modeling. The intensity and label dictionaries are learned from training images with associated label information of (a subset) of the pixels based...

  6. Generic Patch Inference

    DEFF Research Database (Denmark)

    Andersen, Jesper; Lawall, Julia Laetitia

    2008-01-01

    A key issue in maintaining Linux device drivers is the need to update drivers in response to evolutions in Linux internal libraries. Currently, there is little tool support for performing and documenting such changes. In this paper we present a tool, spfind, that identifies common changes made...... developers can use it to extract an abstract representation of the set of changes that others have made. Our experiments on recent changes in Linux show that the inferred generic patches are more concise than the corresponding patches found in commits to the Linux source tree while being safe with respect...

  7. The groundwater subsidy to vegetation: groundwater exchanges between landcover patches

    Science.gov (United States)

    Steven, L. I.; Gimenez, R.; Jobbagy, E. G.

    2015-12-01

    The Gran Chaco is a hot, dry plain, that spans over 60 million hectares across Bolivia, Paraguay, Brazil and Argentina. It supports high biodiversity in its dry forest and savannahs, but is rapidly being converted to agriculture in response to growing soy demand and technology including genetic modification and zero-till, that has made cultivation in drier landscapes more viable. Under natural conditions, the deep-rooted, native vegetation of the Chaco effectively captured all rainfall for evapotranspiration resulting in near zero groundwater recharge under the dry forest. Conversion to shallower rooted soy and corn, combined with the fallow period prior to the growing season, reduces evapotranspiration and allows some water to percolate through the root zone and recharge the groundwater system. When this groundwater recharge occurs, it creates groundwater mounding and a hydraulic gradient that drives flow to adjacent landcover patches where recharge does not occur. As the watertable rises, groundwater becomes available to the deep-rooted, dry forest vegetation. We develop a soil and groundwater flow model to simulate infiltration, percolation, evaporation, rootwater uptake, groundwater recharge and the lateral transfer of water between adjacent landcover patches to quantify this groundwater subsidy from converted agricultural lands to remnant patches of dry forest.

  8. Cylindrical Bending of Deformable Textile Rectangular Patch Antennas

    Directory of Open Access Journals (Sweden)

    Freek Boeykens

    2012-01-01

    Full Text Available Textile patch antennas are well known as basic components for wearable systems that allow communication between a human body and the external world. Due to their flexibility, textile antennas are subjected to bending when worn, causing a variation in resonance frequency and radiation pattern with respect to the flat state in which their nominal design is performed. Hence, it is important for textile antenna engineers to be able to predict these performance parameters as a function of the bending radius. Therefore, we propose a comprehensive analytical model that extends the cylindrical cavity model for conformal rigid patch antennas by incorporating the effects of patch stretching and substrate compression. It allows to predict the resonance frequency and the radiation pattern as a function of the bending radius. Its validity has been verified experimentally. Unlike previous contributions, which concerned only qualitative studies by means of measurements and numerical full-wave simulations, the proposed model offers advantages in terms of physical insight, accuracy, speed, and cost.

  9. Ebola Vaccination Using a DNA Vaccine Coated on PLGA-PLL/γPGA Nanoparticles Administered Using a Microneedle Patch.

    Science.gov (United States)

    Yang, Hung-Wei; Ye, Ling; Guo, Xin Dong; Yang, Chinglai; Compans, Richard W; Prausnitz, Mark R

    2017-01-01

    Ebola DNA vaccine is incorporated into PLGA-PLL/γPGA nanoparticles and administered to skin using a microneedle (MN) patch. The nanoparticle delivery system increases vaccine thermostability and immunogenicity compared to free vaccine. Vaccination by MN patch produces stronger immune responses than intramuscular administration. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Space-weather MDI Active Region Patches (SMARPs)

    Science.gov (United States)

    Bobra, Monica

    2017-08-01

    We are developing a new data product from the Michelson Doppler Imager (MDI) onboard the Solar and Heliospheric Observatory (SoHO) called Space-weather MDI Active Region Patches (SMARPs). The SMARP data series provide maps of the photospheric line-of-sight magnetic field in patches that encompass automatically tracked magnetic concentrations, or active regions, for their entire lifetime. These concentrations are automatically detected in the photospheric line-of-sight magnetic field data using a method described in Turmon et al. (2010) and, thus, are necessarily different from NOAA's definition of an active region. As such, these regions are assigned their own identification number, or SMARP number, which is also linked to a NOAA active region number should it exist. In addition, keywords in the SMARP data series include parameters that concisely characterize the magnetic field distribution. These parameters may be useful for active region event forecasting and for identifying regions of interest. These parameters are calculated per patch and are available on a 96 minute cadence.The SMARP data product is designed to provide seamless coverage with its counterpart, the Space-weather HMI Active Region Patches (SHARPs), described in Bobra et al. (2014). Together, the SMARP and SHARP data series provide continuous coverage of tracked active regions for two solar cycles from 1996 to the present day. The SMARP data series, which runs from April 1996 to October 2010, contains 9496 unique active regions tracked throughout their lifetime. The SHARP data series, which runs from May 2010 to the present day, contains (as of May 30, 2017) 3883 unique active regions tracked throughout their lifetime. In addition, the two series contain 118 unique active regions during the overlap period between May and October 2010. SMARP data will be available at jsoc.stanford.edu and the photospheric line-of-sight magnetic field maps will be available in either of two different coordinate

  11. Imaging of the most frequent superficial soft-tissue sarcomas

    Energy Technology Data Exchange (ETDEWEB)

    Morel, Melanie; Taieb, Sophie; Ceugnart, Luc [Centre Oscar Lambret, Department of Radiology, Lille (France); Penel, Nicolas [Centre Oscar Lambret, Department of Oncology, Lille (France); Mortier, Laurent [Centre Hospitalier Universitaire de Lille, Department of Dermatology, Hopital Claude Huriez, Lille (France); Vanseymortier, Luc [Centre Oscar Lambret, Department of Surgery, Lille (France); Robin, Y.M. [Centre Oscar Lambret, Departement of Pathology, Lille (France); Gosset, Pierre [Groupement Hospitalier de l' Institut Catholique-Faculte Libre de Medecine de Lille, Department of Pathology, Hopital Saint-Philibert, Lomme (France); Cotten, Anne [Centre Hospitalier Universitaire de Lille, Department of Musculoskeletal Radiology, Centre Hopital Roger Salengro, Lille (France)

    2011-03-15

    Superficial soft-tissue sarcomas are malignant mesenchymal tumors located within the cutaneous and/or subcutaneous layers. Most superficial soft-tissue sarcomas are low-grade tumors; yet, the risk of local recurrence is high, and initial wide surgery is the main prognostic factor. Some of these superficial sarcomas may grow, following an infiltrative pattern, and their real extent may be underestimated clinically. Imaging techniques are useful to determine precisely the real margins of the tumor, especially in cases of clinically doubtful or recurrent or large superficial lesions. Imaging tools enable one to determine the relationship with the superficial fascia separating the subcutaneous layer from the underlying muscle. In our institution ultrasonographic examination is followed by magnetic resonance (MR) imaging when the size of the lesion exceeds 3-5 cm. Imaging assessment is performed prior to biopsy, enabling optimal surgical management. Imaging features of the main superficial sarcomas are detailed in the following article, according to their major locations: those arising in the epidermis and/or dermis, which are most often diagnosed by dermatologists, and the subcutaneous sarcomas. (orig.)

  12. Skin permeability and pharmacokinetics of diclofenac epolamine administered by dermal patch in Yorkshire-Landrace pigs

    Directory of Open Access Journals (Sweden)

    Tse S

    2012-10-01

    Full Text Available Susanna Tse,1 Kendall D Powell,2 Stephen MacLennan,3 Allan R Moorman,4 Craig Paterson,5 Rosonald R Bell11Pfizer Inc, Groton, CT, USA; 2Tandem Labs, Durham, NC, USA; 3BioCryst Pharmaceuticals Inc, Durham, NC, USA; 4Alta Vetta Pharmaceutical Consulting LLC, Durham, NC, USA; 5Salix Pharmaceuticals Inc, Raleigh, NC, USAPurpose: This study compared the pharmacokinetic profile, and systemic and local absorption of diclofenac, following dermal patch application and oral administration in Yorkshire- Landrace pigs.Patients and methods: Twelve anesthetized, female, Yorkshire-Landrace pigs were randomized to receive either the dermal patch (FLECTOR® patch, 10 × 14 cm; Alpharma Pharmaceuticals, a subsidiary of Pfizer Inc, New York, NY or 50 mg oral diclofenac (Voltaren®; Novartis, East Hanover, NJ. Tissue (skin area of 2 × 2 cm and underlying muscles approximately 2–3 cm in depth and blood (10 mL samples were collected at timed intervals up to 11.5 hours after initial patch application or oral administration. The concentrations of diclofenac in plasma, skin, and muscle samples were analyzed using validated ultra performance liquid chromatography tandem mass spectrometric methods.Results: Peak systemic exposure of diclofenac was very low by dermal application compared with oral administration (maximum concentration [Cmax] values of 3.5 vs 9640 ng/mL, respectively. Absorption of diclofenac into underlying muscles beneath the dermal patch was sustained, and followed apparently zero-order kinetics, with the skin serving as a depot with elevated concentrations of diclofenac. Concentrations of diclofenac in muscles beneath the patch application site were similar to corresponding tissues after oral administration (Cmax values of 879 and 1160 ng/mL, respectively. In contrast to the wide tissue distribution of diclofenac after oral administration, dermal patch application resulted in high concentrations of diclofenac only on the treated skin and immediate

  13. MOLECULAR GENETIC MARKERS AS PREDICTORS OF SUPERFICIAL BLADDER CANCER

    Directory of Open Access Journals (Sweden)

    A. Yu. Babayan

    2009-01-01

    Full Text Available A system of clinical and morphological criteria is currently used to determine the pattern of superficial bladder cancer (SBC. However, this system does not completely reflect the clinical potential of SBC and needs additional markers. The purpose of this study was to search for and evaluate molecular genetic disorders as additional markers of the course of SBC. The diagnostic panel included the deletion of the loci 3р14, 9р21, 9q34, 17р13 (ТР53, mutations of exon 7 of the FGFR3 gene, and hypermethylation of the promoter regions of the RASSF1, RARB, p16, p14, CDH1 genes. The study was made on 108 matched samples (tumor/peripheral blood obtained from patients with SBC. The deletions of the loci 3р14, 9р21 and anomalous methylation of the RARb and p16 genes are markers of the worse course of SBC while FGFR3 gene mutation is a marker of better prognosis. In the context of estimation of the relapsing potential of a primary tumor, the 9p21 locus deletion is a marker associated with recurrence within the first year after malignancy resection. The group of molecular genetic markers determined by the authors for poor prognosis in combination with classical clinical and morphological criteria will specify the pattern of the course of the disease and its prognosis.

  14. The Effectiveness of Diclofenac Sodium in the Treatment of Mondor's Disease of the Breast: The Topical Patch Compared to the Oral Capsules.

    Science.gov (United States)

    Shirah, Bader Hamza; Shirah, Hamza Assad; Alonazie, Wedad Salem

    2017-07-01

    Mondor's disease of the breast is a rare, benign sclerosing superficial thrombophlebitis of the subcutaneous veins of the anterior or lateral chest wall, which is treated conservatively. We aim in this study to evaluate the outcome and effectiveness of our treatment protocol using oral diclofenac sodium and topical diclofenac sodium patch in 172 patients. A retrospective database analysis of 172 female patients between January 2001 and December 2010 was done. The treatment protocol consisted of group 1: treatment by oral diclofenac sodium 100 mg once daily for 3 weeks. Group 2: treatment by diclofenac sodium patches for 8 hours twice daily (morning and evening) for 1 week. The patients were instructed to document the time as soon as pain relief is achieved following the patch application and the intake of the oral dose. The incidence rate was 2.49%. Diclofenac sodium patch was statistically found to be significantly better in subsiding the inflammatory process of the veins, relieving the pain, and enhancing faster healing rate. We conclude that diclofenac sodium patch showed a promising role in the treatment of Mondor's disease of the breast by significantly decreasing the inflammatory process due to its transdermal migration action within a short period and the ability to reach a high local concentration. It achieved the best results for rapid relief of pain and disease regression compared to the oral capsules. Therefore, our protocol was changed to implement diclofenac sodium patch as the first choice in treating Mondor's disease of the breast. © 2017 Wiley Periodicals, Inc.

  15. Comparative study of icy patches on comet nuclei

    Science.gov (United States)

    Oklay, Nilda; Pommerol, Antoine; Barucci, Maria Antonietta; Sunshine, Jessica; Sierks, Holger; Pajola, Maurizio

    2016-07-01

    Cometary missions Deep Impact, EPOXI and Rosetta investigated the nuclei of comets 9P/Tempel 1, 103P/Hartley 2 and 67P/Churyumov-Gerasimenko respectively. Bright patches were observed on the surfaces of each of these three comets [1-5]. Of these, the surface of 67P is mapped at the highest spatial resolution via narrow angle camera (NAC) of the Optical, Spectroscopic, and Infrared Remote Imaging System (OSIRIS, [6]) on board the Rosetta spacecraft. OSIRIS NAC is equipped with twelve filters covering the wavelength range of 250 nm to 1000 nm. Various filters combinations are used during surface mapping. With high spatial resolution data of comet 67P, three types of bright features were detected on the comet surface: Clustered, isolated and bright boulders [2]. In the visible spectral range, clustered bright features on comet 67P display bluer spectral slopes than the average surface [2, 4] while isolated bright features on comet 67P have flat spectra [4]. Icy patches observed on the surface of comets 9P and 103P display bluer spectral slopes than the average surface [1, 5]. Clustered and isolated bright features are blue in the RGB composites generated by using the images taken in NIR, visible and NUV wavelengths [2, 4]. This is valid for the icy patches observed on comets 9P and 103P [1, 5]. Spectroscopic observations of bright patches on comets 9P and 103P confirmed the existence of water [1, 5]. There were more than a hundred of bright features detected on the northern hemisphere of comet 67P [2]. Analysis of those features from both multispectral data and spectroscopic data is an ongoing work. Water ice is detected in eight of the bright features so far [7]. Additionally, spectroscopic observations of two clustered bright features on the surface of comet 67P revealed the existence of water ice [3]. The spectral properties of one of the icy patches were studied by [4] using OSIRIS NAC images and compared with the spectral properties of the active regions observed

  16. Patching It Up, Pulling It Forward

    Directory of Open Access Journals (Sweden)

    Marlon E. Pierce

    2015-11-01

    Full Text Available An important reason for making any software open source is to encourage code and other community contributions, resulting in more diverse developer communities coalescing around valuable software efforts. We believe the full picture of open developer communities is underappreciated by scientific and cyberinfrastructure open source software efforts. Free and open source licensing is popular in scientific and cyberinfrastructure software, and Web-based tools for source code management (such as GitHub and Bitbucket are in common use, but community building efforts and associated governance models that foster these communities need improvement. We propose here a simple mechanism to address this problem: developers should be given incentives to submit patches and to make other measurable contributions to code bases that they use but are not otherwise connected to, and projects should be given incentives to accept these outside contributions. As an example implementation, we outline a contest system with small monetary rewards for individuals and recognition for both individuals and projects. The goal is to change the mindset of scientific and cyberinfrastructure developers, converting them from passive downstream users to active contributors. We hypothesize that this easily measurable concrete action will contribute to the sustainability of many projects and also create a more flexible scientific workforce. Building this effort on currently available, federally funded software will establish a foundation of public data that can be used to verify our hypothesis. More broadly, the effort will demonstrate the benefits for scientific and cyberinfrastructure projects that adopt workable governance models that are already well established in the broader open source software ecosystem.

  17. Patching genes to fight disease

    Energy Technology Data Exchange (ETDEWEB)

    Holzman, D.

    1990-09-03

    The National Institutes of Health has approved the first gene therapy experiments, one of which will try to cure cancer by bolstering the immune system. The applications of such therapy are limited, but the potential aid to people with genetic diseases is great.

  18. Hypersensitivity reactions to metallic implants-diagnostic algorithm and suggested patch test series for clinical use

    DEFF Research Database (Denmark)

    Schalock, Peter C; Menné, Torkil; Johansen, Jeanne D

    2011-01-01

    algorithm to guide the selection of screening allergen series for patch testing is provided. At a minimum, an extended baseline screening series and metal screening is necessary. Static and dynamic orthopaedic implants, intravascular stent devices, implanted defibrillators and dental and gynaecological......Cutaneous and systemic hypersensitivity reactions to implanted metals are challenging to evaluate and treat. Although they are uncommon, they do exist, and require appropriate and complete evaluation. This review summarizes the evidence regarding evaluation tools, especially patch and lymphocyte...... transformation tests, for hypersensitivity reactions to implanted metal devices. Patch test evaluation is the gold standard for metal hypersensitivity, although the results may be subjective. Regarding pre-implant testing, those patients with a reported history of metal dermatitis should be evaluated by patch...

  19. Lack of Methylene Blue Staining in Superficial Epithelia as a Possible Marker for Superficial Lateral Spread of Bile Duct Cancer

    Directory of Open Access Journals (Sweden)

    I. Maetani

    1996-01-01

    epithelia. The cancerous epithelia stained significantly less often than either the normal (p = 0.000005 or the metaplastic (p = 0.001 epithelia. Evaluation of methylene blue staining during PTCS revealed that this stain was absorbed by the cholangial epithelia, not superficially stuck to it. The difference in methylene blue staining properties between the cancerous and normal epithelia could be helpful to clarify the boundary of superficial lateral spread of bile duct cancer.

  20. Stability of patches of oasis landscape in arid areas: A case study of Sangong River Watershed, Xinjiang, China

    Institute of Scientific and Technical Information of China (English)

    LUO Geping; ZHOU Chenghu; CHEN Xi

    2006-01-01

    The stability of oases is one of the key scientific issues in the process of evolution and management of oases in arid areas. The stability of oases and its representation are also different at different scales. This paper deals with the stability of oases at the landscape patch scale with a case study in the Sangong River Watershed of Tianshan Mountains.We employed the remote sensing, geographic information system and mathematical statistical methods to process the remote sensing images of three periods in 1978, 1987 and 1998, and put forward the approaches for representing the oasis stability at the landscape patch scale. The landscape control capacity of oasis patches is a kind of natural driving forces of the dynamic landscape change. The control capacity of a certain patch type on landscape change increases with its area and shape complexity and contrasts between it and other patches, and reduces with its spatial distances between it and other patches. The patch type with the strongest control capacity should be the matrix of landscape. The conversion of oasis landscape patches results from both natural and anthropogenic driving forces, particularly the anthropogenic driving forces. The higher the conversion proportion is, the lower the stability of patch types is and the stronger the anthropogenic disturbance is. The patch type with the strongest net control capacity in the Sangong River Watershed in 1987 was the desert grassland, which was the matrix of landscapes; but the matrix of landscapes had been changed into the irrigated lands in 1987 and 1998.The control capacities of landscape patches on the oasis landscape evolution have gradually reduced with time in the Sangong River Watershed, and the change extents also have reduced gradually. This reveals that the interaction among the landscape patch types generally tends to reduce, and the natural stability of the oasis landscape patches generally tends to increase. However, the conversion among the

  1. How Does Patch Clamp Work?--An easy approach to understanding patch clamp mechanism

    Institute of Scientific and Technical Information of China (English)

    关兵才; 李之望

    2003-01-01

    In order to help patch clamp users,most of whom are not good enough at electrics and electronics,to understandthe complicated principles of patch clamp technique,we present a readily accessible explanation of patch clamp mechanism,in-cluding basic analysis of membrane currents under voltage clamp,achievement of voltage clamp and current recording,capaci-tance compensation,series resistance compensation,voltage offset correction,leak subtraction and current clamp,based on ourworking and teaching experience and with the aid of some useful formulae.

  2. Lidocaine 5% patch for localized neuropathic pain: progress for the patient, a new approach for the physician

    Directory of Open Access Journals (Sweden)

    Guy Hans

    2010-03-01

    Full Text Available Guy Hans1,2, Dominique Robert3, Johanna Verhulst2, Marcel Vercauteren1,21Department of Anesthesiology, 2Multidisciplinary Pain Center, 3Department of Intensive Care, Antwerp University Hospital, Edegem, BelgiumAbstract: Neuropathic pain (NeP syndromes remain a difficult-to-treat medical entity. Despite a growing number of pharmacological and invasive analgesic therapies the results remain less than optimal because of insufficient analgesic efficacy and/or occurrence of pronounced side effects. Current guidelines propose the use of multimodal and balanced pharmacological therapies, focused on the underlying pathophysiological mechanisms (mechanistic approach. Lidocaine 5% patches are a new treatment option currently licensed for the treatment of postherpetic neuralgia. However, these patches can also be used for the treatment of different types of superficial NeP syndromes, such as diabetic polyneuropathy. Their therapeutic success, however, largely depends on the correct identification of appropriate patients and pain syndromes. This manuscript outlines the correct identification of patients and proper use of these patches in order to ensure as much as possible the therapeutic efficacy of this new treatment option.Keywords: neuropathic pain, lidocaine, patch

  3. Amniotic membrane transplant with superficial keratectomy in superficial corneal degenerations: Efficacy in a rural population of north India

    Directory of Open Access Journals (Sweden)

    Rao Aparna

    2008-01-01

    Full Text Available Aim: To evaluate the applicability and efficacy of superficial keratectomy with transplantation of preserved amniotic membrane in superficial corneal degenerations in a rural population of Northern India in terms of visual improvement and surface regularization. Settings: Peripheral referral center in rural north India. Materials and Methods: This was a prospective non-comparative interventional case series where 24 eyes of 20 farmers from peripheral rural areas (M:F = 19:1 with visually significant superficial degenerative disorders (15 eyes with climatic droplet keratopathy one of which was associated with Salzmann nodular degeneration and nine eyes with band-shaped keratopathy were subjected to amniotic membrane transplantation (single or multiple layer combined with superficial keratectomy. Subjective and objective outcomes after surgery were evaluated and analyzed and statistical significance of the outcomes in various disorders was evaluated. Results: Eighty-eight per cent (21 eyes had symptomatic relief from distressing preoperative symptoms while postoperative visual improvement by two or more lines was achieved in 23 eyes (96% over a mean follow-up period of 26.8 ± 10.2 months. The surface irregularity present preoperatively was relieved in 23 cases while postoperative decline of vision with visually significant scarring was seen in one case (4%, which was labeled as failure. Conclusions: Amniotic membrane transplant with superficial keratectomy helped achieve subjective comfort, visual rehabilitation and clinical regularization of the corneal surface in superficial corneal degenerations during the mean followup of 26.8 ± 10.2 months in rural setups.

  4. Umbilical Hernia Repair with Proceed Ventral Patch

    Directory of Open Access Journals (Sweden)

    Salati Sajad Ahmad

    2014-07-01

    Full Text Available Umbilical hernia is one the commonest surgical lesions and there is a variety of methods available for its repair. Proceed Ventral Patch is a recent and novel innovation in hernia management and we present a successful management of umbilical hernia in a 45 years old obese patient with this technique

  5. Wireless Arm Patch May Blunt Migraine Pain

    Science.gov (United States)

    ... electrodes and a chip in the patch produce electric impulses that block pain signals from reaching the brain, the study authors said. When a migraine starts, you can control the intensity of the electric impulses using a smartphone app, explained lead researcher ...

  6. A method for detecting hydrophobic patches protein

    NARCIS (Netherlands)

    Lijnzaad, P.; Berendsen, H.J.C.; Argos, P.

    1996-01-01

    A method for the detection of hydrophobic patches on the surfaces of protein tertiary structures is presented, it delineates explicit contiguous pieces of surface of arbitrary size and shape that consist solely of carbon and sulphur atoms using a dot representation of the solvent-accessible surface,

  7. Evidence-based diagnosis in patch testing

    NARCIS (Netherlands)

    van der Valk, PGM; Devos, SA; Coenraads, PJ

    2003-01-01

    Evidence-based medicine (EBM) is defined as the integration of the best research evidence with clinical expertise and patient values. Based on the principles of EBM, we can conclude that patch testing is cost-effective only if patients are selected on the basis of a clear-cut clinical suspicion of c

  8. Positive patch test reactions to oxidized limonene

    DEFF Research Database (Denmark)

    Bråred Christensson, Johanna; Andersen, Klaus E; Bruze, Magnus

    2014-01-01

    BACKGROUND: R-Limonene is a common fragrance terpene found in domestic and industrial products. R-Limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a recent multicentre study, 5.2% (range 2.3-12.1%) of 2900 patients showed a positive patch test reactio...

  9. Soil, Seeds, and the Pumpkin Patch!

    Science.gov (United States)

    Phillips, Marianne; Vowell, Julie

    2013-01-01

    "Soil, Seeds, and the Pumpkin Patch!" is an integrated unit designed to provide elementary school teachers with ideas for using hands-on activities, fostering inquiry and valuable discussion, and using technology as a learning tool. This unit integrates science with language arts, mathematics, literature, and technology. During this unit, students…

  10. Capsaicin patch (Qutenza) for postherpetic neuralgia.

    Science.gov (United States)

    2011-05-30

    The FDA has approved a topical 8% patch formulation of capsaicin (Qutenza-NeurogesX), available only by prescription, for local treatment of postherpetic neuralgia. Postherpetic neuralgia occurs after herpes zoster in about one third of patients ≥60 years old and can persist for months or even years.

  11. Juno Microwave Radiometer Patch Array Antennas

    Science.gov (United States)

    Chamberlain, N.; Chen, J.; Focardi, P.; Hodges, R.; Hughes, R.; Jakoboski, J.; Venkatesan, J.; Zawadzki, M.

    2009-01-01

    Juno is a mission in the NASA New Frontiers Program with the goal of significantly improving our understanding of the formation and structure of Jupiter. This paper discusses the modeling and measurement of the two patch array antennas. An overview of the antenna architecture, design and development at JPL is provided, along with estimates of performance and the results of measurements.

  12. Bye-Bye Flu Shot, Hello Patch?

    Science.gov (United States)

    ... for intramuscular injection [a flu shot] by a health care professional," he added. Also, "this patch does not need to be refrigerated -- it has ... National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page ...

  13. A method for detecting hydrophobic patches protein

    NARCIS (Netherlands)

    Lijnzaad, P.; Berendsen, H.J.C.; Argos, P.

    1996-01-01

    A method for the detection of hydrophobic patches on the surfaces of protein tertiary structures is presented, it delineates explicit contiguous pieces of surface of arbitrary size and shape that consist solely of carbon and sulphur atoms using a dot representation of the solvent-accessible surface,

  14. Patch-mosaic burning: a new paradigm for savanna fire management in protected areas?

    Directory of Open Access Journals (Sweden)

    C.L. Parr

    1999-02-01

    Full Text Available The shift in ecological thinking, from equilibrium to non-equilibrium processes has been accompanied by a move to encourage heterogeneity rather than homogeneity in landscapes. Spatial and temporal heterogeneity is thought to be a major source of biotic diversity, and disturbances such as fire, producing heterogeneity are now recognised as being important. A patch-mosaic system of burning is based on the premise that fire pattern is a surrogate for diversity, and produces a range of patches in the landscape with unique patch characteristics and fire histories. A patch-mosaic system of burning is supported historically and empirically through field studies. However, there is a need for more research into the effects of various aspects of patch and fire variables on biotic diversity, especially in savannas where our understanding is particularly poor. Landscape-scale experiments, like those to be established in the Kruger National Park, South Africa are necessary to test different burning regimes. Challenges to patch- mosaic burning include determining the 'natural' range of variation for fire parameters, implementing random ignitions, and cost-effective fire scar mapping at the appropriate resolution. An adaptive management approach should be adopted to deal with the ignorance and uncertainties that characterise the management of savanna ecosystems. This should be applied with both modelling and monitoring as key elements in this process.

  15. Eradication of superficial fungal infections by conventional and novel approaches: a comprehensive review.

    Science.gov (United States)

    Kumar, Lalit; Verma, Shivani; Bhardwaj, Ankur; Vaidya, Shubha; Vaidya, Bhuvaneshwar

    2014-02-01

    During the last two decades, the occurrence of fungal infections either superficial or systemic has been increasing. Moreover, fungal infections become more difficult to treat when they show coupling with immunogenic diseases like AIDS. Superficial fungal infections are associated with skin, nail and eye and are less prominent to systemic infection. However, it may be dangerous if not treated properly. It is usually observed that conventional formulations including cream, powder, gels etc. are used to treat skin fungal infections even for the deep seated fungal infections. However, these formulations show various side-effects on the application site like burning, redness and swelling. Further, due to the immediate release of drug from these formulations they can stimulate the immune system of body generating high impact allergic reactions. Deep seated fungal infections like invasive aspergillosis and invasive candidiasis may be more difficult to treat because the drug released from conventional topical formulation can not reach at the target site due to the low penetration capacity. Similarly, in case of fungal infection of nail and eye, conventional formulations show problem of less bioavailability. Thus, to overcome the drawbacks of conventional therapy a lot of research works have been carried out to develop novel formulations of antifungal drugs to deliver them superficially. Novel formulations explored for the skin delivery of antifungal drugs include liposomes, niosomes, ethosomes, microemulsions, nanoparticles, microspheres and micelles. These formulations show extended or sustained release of drug, minimizing the side effect on application site, enhancing bioavailability and reducing the dosing frequency. Further, these formulations also show penetration into the deep skin to treat invasive fungal infections. Novel formulations explored in treatment of fungal infections of eye are liposomes and nanoparticles and whether for nail fungal infections

  16. Abundance, distribution and patch formation of zooplankton

    Science.gov (United States)

    Paffenhöfer, Gustav-Adolf; Sherman, Byron K.; Lee, Thomas N.

    The goal of studies described here was to determine the responses of zooplankton taxa to phytoplankton patches which develop in and near intrusions of cold, nutrient-rich Gulf Stream water. To achieve this goal we determined the horizontal and vertical distributions of abundant mesozooplankton taxa on the south-eastern continental shelf of the USA between 29°30‧ and 31°N. The study period was from June 23 to August 16, 1981. Highest concentrations of zooplankton usually occurred in and near patches of phytoplankton. Increased phytoplankton appeared to trigger the formation of patches of the calanoid copepod Temora turbinata and the cyclopoid copepods Oithona spp. and Oncaea spp. The patches of zooplankton had greater alongshore than cross-shelf dimensions. T. turbinata responded rapidly to increased concentrations of phytoplankton by reproducing and aggregating in and above intruded waters. Oithonidae which were often, but not always, abundant in phytoplankton patches eventually attained high concentrations over most of the middle and part of the inner shelf. Their concentration and that of Oncaeidae increased steadily. Oncaeidae were not abundant in recently upwelled waters, as was T. turbinata but reached high concentrations in older intrusions when the abundance of T. turbinata remained level or decreased slowly. Both cyclopoid taxa are thought to reproduce slowly (egg sacs) compared to T. turbinata. Another taxon, the doliolids, became abundant far more rapidly in intruded waters (by asexual reproduction) than did the other three taxa. Doliolids were the most opportunistic intrusion zooplankton form. They do not regularly occur in low abundance on the shelf, as do the three copepod taxa, but develop in pulses in regions where T. turbinata and Oncaea are not abundant. Of the four taxa studied the abundance of doliolids increased and decreased most rapidly, whereas Oithona and Oncaea increased slowly and did not decrease during the study period. T. turbinata

  17. Magnetic Patches in Internetwork Quiet Sun

    Science.gov (United States)

    De Wijn, Alfred; Lites, B.; Berger, T.; Shine, R.; Title, A.; Katsukawa, Y.; Tsuneta, S.; Suematsu, Y.; Shimizu, T.; Hinode Team

    2007-05-01

    We study strong flux elements in the quiet sun in the context of the nature of quiet-sun magnetism, its coupling to chromospheric, transition-region and coronal fields, and the nature of a local turbulent dynamo. Strong, kilogauss flux elements show up intermittently as small bright points in G-band and Ca II H images. Although bright points have been extensively studied in the magnetic network, internetwork magnetism has only come under scrutiny in recent years. A full spectrum of field strengths seems to be ubiquitously present in the internetwork at small spatial scales, with the stronger elements residing in intergranular lanes. De Wijn et al. (2005) found that bright points in quiet sun internetwork areas appear recurrently with varying intensity and horizontal motion within long-lived patches that outline cell patterns on mesogranular scales. They estimate that the "magnetic patches" have a mean lifetime of nine hours, much longer than granular timescales. We use multi-hour sequences of G-band and Ca II H images as well as magnetograms recorded by the Hinode satellite to follow up on their results. The larger field of view, the longer sequences, the addition of magnetograms, and the absence of atmospheric seeing allows us to better constrain the patch lifetime, to provide much improved statistics on IBP lifetime, to compare IBPs to network bright points, and to study field polarity of IBPs in patches and between nearby patches. Hinode is an international project supported by JAXA, NASA, PPARC and ESA. We are grateful to the Hinode team for all their efforts in the design, build and operation of the mission.

  18. Biochemical composition of the superficial layer of articular cartilage.

    Science.gov (United States)

    Crockett, R; Grubelnik, A; Roos, S; Dora, C; Born, W; Troxler, H

    2007-09-15

    To gain more information on the mechanism of lubrication in articular joints, the superficial layer of bovine articular cartilage was mechanically removed in a sheet of ice that formed on freezing the cartilage. Freeze-dried samples contained low concentrations of chondroitin sulphate and protein. Analysis of the protein by SDS PAGE showed that the composition of the sample was comparable to that of synovial fluid (SF). Attenuated total reflection infrared (ATR-IR) spectroscopy of the dried residue indicated that the sample contained mostly hyaluronan. Moreover, ATR-IR spectroscopy of the upper layer of the superficial layer, adsorbed onto silicon, showed the presence of phospholipids. A gel could be formed by mixing hyaluronan and phosphatidylcholine in water with mechanical properties similar to those of the superficial layer on cartilage. Much like the superficial layer of natural cartilage, the surface of this gel became hydrophobic on drying out. Thus, it is proposed that the superficial layer forms from hyaluronan and phospholipids, which associate by hydrophobic interactions between the alkyl chains of the phospholipids and the hydrophobic faces of the disaccharide units in hyaluronan. This layer is permeable to material from the SF and the cartilage, as shown by the presence of SF proteins and chondroitin sulphate. As the cartilage dries out after removal from the joint, the phospholipids migrate towards the surface of the superficial layer to reduce the surface tension. It is also proposed that the highly efficient lubrication in articular joints can, at least in part, be attributed to the ability of the superficial layer to adsorb and hold water on the cartilage surface, thus creating a highly viscous boundary protection.

  19. Experimental Study on Mine Spoils During Superficial Geochemical Processes

    Institute of Scientific and Technical Information of China (English)

    王一先; 白正华

    2002-01-01

    Based on the mineral and chemical compositions of spoils taken from the Shilu Cu-Mo deposit and Hetai gold deposit ,the leaching and batch experiments were made on spoils taken from these two deposits using the leaching column designed by the authors.The experimental results showed that it is not always true that the imine drainage is acidic.Its acidity depends on acid-buffering capacity of gangue,host rock and its alteration mineral assemblage.The composi-tion of the drainage water is related with the interaction between superficial or underground water and solid materials in the spoils,including minerals,hydroxides and amorphous substances.The leaching extent of the element is related with its occurrence form in the deposit.The prefer-ential flow results in leaching-out of heavy metals in large amounts.So it is important to prevent the generating of preferential flow in the system.The results will provide very important grounds for the comprehensive management of land and ecological rehabilitation of the mine site.

  20. Experimental Study on Mine Spoils During Superficial Geochemistry Processes

    Institute of Scientific and Technical Information of China (English)

    王一先; 白正华

    2002-01-01

    Based on the mineral and chemical compositions of spoils taken from the Shilu Cu-Mo deposit and Hetai gold deposit, the leaching and batch experiments were made on spoils taken from these two deposits using the leaching column designed by the authors. The experimental results showed that it is not always true that the mine drainage is acidic. Its acidity depends on acid-buffering capacity of gangue, host rock and its alteration mineral assemblage. The composition of the drainage water is related with the interaction between superficial or underground water and solid materials in the spoils, including minerals, hydroxides and amorphous substances. The leaching extent of the element is related with its occurrence form in the deposit. The preferential flow results in leaching-out of heavy metals in large amounts. So it is important to prevent the generating of preferential flow in the system. The results will provide very important grounds for the comprehensive management of land and ecological rehabilitation of the mine site.

  1. Light transmission and preference of eye patches for occlusion treatment.

    Directory of Open Access Journals (Sweden)

    Hwan Heo

    Full Text Available PURPOSE: To investigate light transmission and preference for six eye patches for occlusion therapy. METHODS: Six patches were examined, including; Ortopad Fun Pack, Ortopad Flesh, Kawamoto A-1, Kawamoto A-2, 3M Opticlude, and Everade Eye Guard. The size and the presence of a light blocking pad of patches were investigated. The amount of light transmitted through the patches was evaluated, using a digital light meter and a model eye, in three different environments; indoors with fluorescent light, outdoors on a sunny day, and strong light from illuminator. After patching the normal eye, the flash visual evoked potential (VEP was measured. Thirty patients with amblyopia or horizontal strabismus, who received occlusion therapy as initial treatment, were included. After using all six patches, patients completed a 7-item questionnaire regarding the patch preference for size, color and shape, adhesive power, pain with removal, skin irritation after removing patch, parent's preference and overall opinion. RESULTS: All patches had a light-blocking pad, except the 3M Nexcare. Ortopad had the strongest light blocking power in the three environments, and the 3M Nexcare had the weakest power. In flash VEP, Ortopad and Kawamoto patches showed flat, but 3M Nexcare and Everade Eye Guard showed normal response. There were significant preferential differences among the patches in all the items of the questionnaire (P<0.05. In comparison between the patches respectively, 3M Nexcare received the lowest satisfaction in pain when removing a patch and skin irritation after removing a patch. Kawamoto A-2 received the lowest score in the overall satisfaction. CONCLUSIONS: We found differences in the light-blocking power and in the preference of the various patches for the occlusion treatment. This is a pilot study regarding only characteristics and preferences of patches. Further clinical studies regarding the relationship between characteristics or preferences of

  2. Effect of eye patching in rehabilitation of neglect

    Directory of Open Access Journals (Sweden)

    Nicola eSmania

    2013-09-01

    Full Text Available Eye patching (monocular or right hemifield has been proposed to improve visuospatial attention to the ignored field in patients with neglect. The aim of this paper is to review the literature on the effects of eye patching in hemispatial neglect after stroke in order to convey evidence-based recommendations to clinicians in stroke rehabilitation. Thirteen intervention studies were selected from the Medline, EMBASE, Scopus, Cochrane Library, CINAHL, PsychINFO, EBRSR and Health Star databases. Methodological quality was defined according to the Physiotherapy Evidence Database. Overall, seven studies used monocular eye patching, five used right hemifield patching and one compared right monocular with right hemifield patching. Seven studies compared normal viewing to monocular or hemifield patching conditions. Six studies included a period of treatment. Three studies included follow-up evaluations. As to the monocular eye patching, four studies reported positive effects of right monocular patching. One study showed an improvement in hemispatial neglect with left monocular patching. Two studies found no superiority of right versus left monocular patching. One study found no effects of right monocular patching. As to the right hemifield eye patching, one study showed improvements in neglect after right hemifield patching. Three studies found that right hemifield patching combined with another rehabilitation technique was more effective than that treatment alone. One study found no differences between right hemifield patching combined with another treatment and that treatment alone. One study found the same effect between right hemifield patching alone and another rehabilitation technique.Our results globally tend to support the usefulness of right hemifield eye patching in clinical practice. In order to define a level of evidence with the standard rehabilitation evidence rating tools, further properly powered randomized controlled trials or meta

  3. DYNAMICS OF A NONLINEAR NON-AUTONOMOUS n-PATCHES PREDATOR-PREY DISPERSION-DELAY MODEL

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    In this paper, a nonlinear nonautonomous predator-prey dispersion model with continuous distributed delay is studied, where all parameters are time-dependent. In this system consisting of n-patches the prey species can disperse among n-patches, but the predator species is confined to one patch and cannot disperse. It is proved that the system is uniformly persistent under any dispersion rate effect. Furthermore, some sufficient conditions are established for the existence of a unique almost periodic solution of the system. The example shows that the criteria in the paper are new, general and easily verifiable.

  4. Multi-Band Miniaturized Patch Antennas for a Compact, Shielded Microwave Breast Imaging Array.

    Science.gov (United States)

    Aguilar, Suzette M; Al-Joumayly, Mudar A; Burfeindt, Matthew J; Behdad, Nader; Hagness, Susan C

    2013-12-18

    We present a comprehensive study of a class of multi-band miniaturized patch antennas designed for use in a 3D enclosed sensor array for microwave breast imaging. Miniaturization and multi-band operation are achieved by loading the antenna with non-radiating slots at strategic locations along the patch. This results in symmetric radiation patterns and similar radiation characteristics at all frequencies of operation. Prototypes were fabricated and tested in a biocompatible immersion medium. Excellent agreement was obtained between simulations and measurements. The trade-off between miniaturization and radiation efficiency within this class of patch antennas is explored via a numerical analysis of the effects of the location and number of slots, as well as the thickness and permittivity of the dielectric substrate, on the resonant frequencies and gain. Additionally, we compare 3D quantitative microwave breast imaging performance achieved with two different enclosed arrays of slot-loaded miniaturized patch antennas. Simulated array measurements were obtained for a 3D anatomically realistic numerical breast phantom. The reconstructed breast images generated from miniaturized patch array data suggest that, for the realistic noise power levels assumed in this study, the variations in gain observed across this class of multi-band patch antennas do not significantly impact the overall image quality. We conclude that these miniaturized antennas are promising candidates as compact array elements for shielded, multi-frequency microwave breast imaging systems.

  5. Efficacy of epidural blood patches for spontaneous low-pressure headaches: a case series.

    Science.gov (United States)

    Ansel, S; Rae, A; Tyagi, A

    2016-12-01

    Patients with a spontaneous cerebrospinal fluid leak, normally at a spinal level, typically present with low-pressure headache. In refractory cases, an epidural blood patch may be attempted. We aimed to assess the efficacy of lumbar epidural blood patching in spontaneous, low-pressure headaches. Methods We retrospectively analysed notes of patients who had an epidural blood patch performed for spontaneous low-pressure headaches in a single centre. Information regarding demographics, radiology and clinic follow-up was extracted from an electronic patient record system. Questionnaires regarding outcome were sent to patients a minimum of 6 months post-procedure. All patients received an epidural blood patch in the lumbar region irrespective of the site of cerebrospinal fluid leak. Results Sixteen patients who underwent lumbar epidural blood patching were analysed (11 female; mean age 43 years). The site of cerebrospinal fluid leak was evident in only 3/16 patients. Thirteen patients attended clinic follow-up; three reported complete headache resolution, four reported improvement in intensity or frequency and six described no change. Five of eight questionnaire respondents reported reduction in pain, and in these responders, mean headache severity improved from 9/10 to 3/10. Five of eight patients returning follow-up questionnaires reported sustained improvement in headache symptoms. Conclusion Epidural blood patch procedures can provide sustained improvement in headache symptoms in selected patients with spontaneous intracranial hypotension, but an untargeted approach has a lower success rate than reported in other case series.

  6. Tolerability of NGX-4010, a capsaicin 8% patch for peripheral neuropathic pain

    Directory of Open Access Journals (Sweden)

    Peppin JF

    2011-11-01

    Full Text Available John F Peppin1, Kristine Majors2, Lynn R Webster3, David M Simpson4, Jeffrey K Tobias5, Geertrui F Vanhove51The Pain Treatment Center of the Bluegrass, Lexington, KY, USA; 2Integrated Clinical Trial Services, Inc, West Des Moines, IA, USA; 3Lifetree Clinical Research and Pain Clinic, Salt Lake City, UT, USA; 4Mount Sinai Medical Center, New York, NY, USA; 5NeurogesX, Inc, San Mateo, CA, USABackground/purpose: NGX-4010 (QUTENZA™; NeurogesX Inc, San Mateo, CA, a capsaicin 8% dermal patch, is licensed in the European Union for the treatment of peripheral neuropathic pain (PNP in nondiabetic adults and in the United States for the treatment of neuropathic pain associated with postherpetic neuralgia (PHN. While NGX-4010 treatment is associated with a low risk of systemic adverse events, patch application-related pain is common and may be managed with local cooling and/or oral analgesics. This article characterizes the tolerability of NGX-4010 and will help to guide any pain management.Methods: This integrated analysis of tolerability data collected from the NGX-4010 clinical study program included 1696 patients with PNP. Patch application-related pain on the treatment day was captured as Numeric Pain Rating Scale (NPRS “pain now” scores while “average pain for the past 24 hours” NPRS scores were analyzed for 7 days following treatment. Other tolerability assessments included the percentage of patients completing ≥90% of the intended treatment duration and patients using medication for patch application-related pain.Results: The mean maximum change in “pain now” NPRS scores from pretreatment levels during and after patch application was 2.6 for all patients. This pain was transient and resolved following patch removal. Mean “average pain for the past 24 hours” NPRS scores returned to baseline by the evening of the treatment day for patients with PHN, and the evening of day 2 for patients with human immunodeficiency virus

  7. The assessment of electrophysiological activity in human-induced pluripotent stem cell-derived cardiomyocytes exposed to dimethyl sulfoxide and ethanol by manual patch clamp and multi-electrode array system.

    Science.gov (United States)

    Hyun, Soo-Wang; Kim, Bo-Ram; Hyun, Sung-Ae; Seo, Joung-Wook

    2017-09-01

    Recently, electrophysiological activity has been effectively measured in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to predict drug-induced arrhythmia. Dimethyl sulfoxide (DMSO) and ethanol have been used as diluting agents in many experiments. However, the maximum DMSO and ethanol concentrations that can be effectively used in the measurement of electrophysiological parameters in hiPSC-CMs-based patch clamp and multi-electrode array (MEA) have not been fully elucidated. We investigated the effects of varying concentrations of DMSO and ethanol used as diluting agents on several electrophysiological parameters in hiPSC-CMs using patch clamp and MEA. Both DMSO and ethanol at concentrations>1% in external solution resulted in osmolality >400mOsmol/kg, but pH was not affected by either agent. Neither DMSO nor ethanol led to cell death at the concentrations examined. However, resting membrane potential, action potential amplitude, action potential duration at 90% and 40%, and corrected field potential duration were decreased significantly at 1% ethanol concentration. DMSO at 1% also significantly decreased the sodium spike amplitude. In addition, the waveform of action potential and field potential was recorded as irregular at 3% concentrations of both DMSO and ethanol. Concentrations of up to 0.3% of either agent did not affect osmolality, pH, cell death, or electrophysiological parameters in hiPSC-CMs. Our findings suggest that 0.3% is the maximum concentration at which DMSO or ethanol should be used for dilution purposes in hiPSC-CMs-based patch clamp and MEA. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Superficial dosimetry imaging of Čerenkov emission in electron beam radiotherapy of phantoms

    Science.gov (United States)

    Zhang, Rongxiao; Fox, Colleen J.; Glaser, Adam K.; Gladstone, David J.; Pogue, Brian W.

    2013-08-01

    Čerenkov emission is generated from ionizing radiation in tissue above 264 keV energy. This study presents the first examination of this optical emission as a surrogate for the absorbed superficial dose. Čerenkov emission was imaged from the surface of flat tissue phantoms irradiated with electrons, using a range of field sizes from 6 cm × 6 cm to 20 cm × 20 cm, incident angles from 0° to 50°, and energies from 6 to 18 MeV. The Čerenkov images were compared with the estimated superficial dose in phantoms from direct diode measurements, as well as calculations by Monte Carlo and the treatment planning system. Intensity images showed outstanding linear agreement (R2 = 0.97) with reference data of the known dose for energies from 6 to 18 MeV. When orthogonal delivery was carried out, the in-plane and cross-plane dose distribution comparisons indicated very little difference (±2-4% differences) between the different methods of estimation as compared to Čerenkov light imaging. For an incident angle 50°, the Čerenkov images and Monte Carlo simulation show excellent agreement with the diode data, but the treatment planning system had a larger error (OPT = ±1˜2%, diode = ±2˜3%, TPS = ±6-8% differences) as would be expected. The sampling depth of superficial dosimetry based on Čerenkov radiation has been simulated in a layered skin model, showing the potential of sampling depth tuning by spectral filtering. Taken together, these measurements and simulations indicate that Čerenkov emission imaging might provide a valuable method of superficial dosimetry imaging from incident radiotherapy beams of electrons.

  9. Long-term evolution of superficial optic disc drusen

    DEFF Research Database (Denmark)

    Malmqvist, Lasse; Lund-Andersen, Henrik; Hamann, Steffen

    2017-01-01

    with hereditary ODD were included. RESULTS: Mean age at initial and follow-up examination was, respectively, 16.8 and 73.3 years. The median follow-up time was 56 years. A minimal or non-existing change in superficial ODD anatomy (size and number) was seen in 10 of 12 eyes. There was a tendency towards more......PURPOSE: Optic disc drusen (ODD) is hyaline deposits in the optic nerve head seen in 1-2% of the population. Long-term evolution of ODD anatomy and visual field defects in ODD patients is a key factor for learning more about pathophysiology and prognosis of the condition. With a median follow......-up period of 56 years, this is the first study that evaluates superficial optic disc anatomy and visual fields in patients with ODD over a life span. METHODS: Observational case series investigating progression of superficial optic disc anatomy and visual fields in ODD patients. Eight patients...

  10. Física de superficies: métodos experimentales

    OpenAIRE

    2012-01-01

    Hace unos 30 años se empezó con el estudio de superficies sólidas y hoy son muchos los investigadores que en el mundo entero se dedican al estudio de las propiedades físicas y químicas de superficies e interfaces.La motivación radica en que en las interacciones entre los diversos sistemas que componen nuestro universo se hallan involucradas sus superficies, razón suficiente para captar la importancia de su estudio para la vida humana y su repercusión tecnológica y económica. A ella habría que...

  11. Patch testing in contact dermatitis of hands and feet

    Directory of Open Access Journals (Sweden)

    Huda M

    1996-01-01

    Full Text Available Eighty clinically diagnosed cases of allergic contact dermatitis of hands and feet when subjected to patch testing, Seventy four (92.5% cases showed positive patch test reactions to different suspected antigens. Maximum number of cases belonged to housewives and tea garden workers which showed positive patch test reaction to vegetables and soaps and detergents and pesticides, respectively.

  12. Physical properties of gum karaya-starch-essential oil patches.

    Science.gov (United States)

    Shcherbina, Yulia; Roth, Zvi; Nussinovitch, Amos

    2010-09-01

    Essential oils are used in foods, cosmetics, and pharmaceuticals. Despite the recent marketing of novel essential-oil-containing patches, there is no information on their production, constituents, or physical properties. The objectives of this study were to produce essential-oil patches and characterize their physical properties. The essential oil of Lavandula angustifolia (lavender) was included at concentrations of 2.5% to 10% in patches manufactured from the exudate gum karaya, propylene glycol, glycerol, emulsifier, and optionally, potato starch as filler. Inclusion of essential oil reduced patch strength, stiffness, and elasticity relative to patches without essential oil. Inclusion of starch in the essential-oil patches strengthened them, but reduced their elasticity. Patches' adhesion to substrate was examined by both peeling and probe-tack tests: the higher the inclusion of essential oils within the patch, the larger the decrease in its adhesion to substrate. Addition of starch to essential-oil-containing patches increased their adhesion relative to their essential-oil-only counterparts. Scanning electron micrographs of the patches provided evidence of entrapped starch granules. Although inclusion of essential oil reduced both the mechanical properties and adhesion of the patches, a high proportion of essential oil can still be included without losing patch integrity or eliminating its adhesiveness to the skin.

  13. Smooth surfaces from rational bilinear patches

    KAUST Repository

    Shi, Ling

    2014-01-01

    Smooth freeform skins from simple panels constitute a challenging topic arising in contemporary architecture. We contribute to this problem area by showing how to approximate a negatively curved surface by smoothly joined rational bilinear patches. The approximation problem is solved with help of a new computational approach to the hyperbolic nets of Huhnen-Venedey and Rörig and optimization algorithms based on it. We also discuss its limits which lie in the topology of the input surface. Finally, freeform deformations based on Darboux transformations are used to generate smooth surfaces from smoothly joined Darboux cyclide patches; in this way we eliminate the restriction to surfaces with negative Gaussian curvature. © 2013 Elsevier B.V.

  14. Bilaterally Weighted Patches for Disparity Map Computation

    Directory of Open Access Journals (Sweden)

    Laura Fernández Julià

    2015-03-01

    Full Text Available Visual correspondence is the key for 3D reconstruction in binocular stereovision. Local methods perform block-matching to compute the disparity, or apparent motion, of pixels between images. The simplest approach computes the distance of patches, usually square windows, and assumes that all pixels in the patch have the same disparity. A prominent artifact of the method is the "foreground fattening effet" near depth discontinuities. In order to find a more appropriate support, Yoon and Kweon introduced the use of weights based on color similarity and spatial distance, analogous to those used in the bilateral filter. This paper presents the theory of this method and the implementation we have developed. Moreover, some variants are discussed and improvements are used in the final implementation. Several examples and tests are presented and the parameters and performance of the method are analyzed.

  15. Metamaterial Embedded Wearable Rectangular Microstrip Patch Antenna

    Directory of Open Access Journals (Sweden)

    J. G. Joshi

    2012-01-01

    Full Text Available This paper presents an indigenous low-cost metamaterial embedded wearable rectangular microstrip patch antenna using polyester substrate for IEEE 802.11a WLAN applications. The proposed antenna resonates at 5.10 GHz with a bandwidth and gain of 97 MHz and 4.92 dBi, respectively. The electrical size of this antenna is 0.254λ×0.5λ. The slots are cut in rectangular patch to reduce the bending effect. This leads to mismatch the impedance at WLAN frequency band; hence, a metamaterial square SRR is embedded inside the slot. A prototype antenna has been fabricated and tested, and the measured results are presented in this paper. The simulated and measured results of the proposed antenna are found to be in good agreement. The bending effect on the performance of this antenna is experimentally verified.

  16. Mesh saliency with adaptive local patches

    Science.gov (United States)

    Nouri, Anass; Charrier, Christophe; Lézoray, Olivier

    2015-03-01

    3D object shapes (represented by meshes) include both areas that attract the visual attention of human observers and others less or not attractive at all. This visual attention depends on the degree of saliency exposed by these areas. In this paper, we propose a technique for detecting salient regions in meshes. To do so, we define a local surface descriptor based on local patches of adaptive size and filled with a local height field. The saliency of mesh vertices is then defined as its degree measure with edges weights computed from adaptive patch similarities. Our approach is compared to the state-of-the-art and presents competitive results. A study evaluating the influence of the parameters establishing this approach is also carried out. The strength and the stability of our approach with respect to noise and simplification are also studied.

  17. Case report: cochlear implantation in a patient with superficial siderosis.

    Science.gov (United States)

    Ryan, Michelle; Piplica, Doris; Zhang, Ming

    2014-12-01

    This is a retrospective case review study. Current understanding of cochlear implantation in patients with superficial siderosis is limited, with roughly 15 reported cases worldwide. The purpose of this study is to report an additional case of cochlear implantation in a patient with superficial siderosis and to contribute to the current literature available on outcomes of implantation in these individuals. One cochlear implant user with superficial siderosis in a tertiary referral center. Therapeutic and rehabilitative. Open set speech perception word scores increased from 0% preimplantation with bilateral hearing aids to 8% postimplantation in the bimodal condition (cochlear implant in the left ear and hearing aid in the right ear). Phoneme scores increased from 16% preimplantation to 36% postimplantation. The patient also demonstrated improvement from 38% preimplantation to 83% postimplantation on a closed set word test. Performance on open set recorded sentences did not improve; however, open set sentences administered live voice revealed an increase in performance from 4% preimplantation to 25% postimplantation in the auditory only condition and from 59% to 86% in the auditory-visual condition. For this patient with superficial siderosis, only marginal improvements in test scores at 11 months postimplantation were seen. Minimally, the use of a cochlear implant did prevent further deterioration of auditory performance. Therefore, patients with superficial siderosis who choose to proceed with cochlear implantation may still report perceived benefit from the maintenance of speech perception abilities even in the presence of minimal improvement. Rapid deterioration in hearing thresholds and speech discrimination before implantation may be an indicator of an actively progressing case of superficial siderosis, which may suggest possible limited benefit from cochlear implantation.

  18. Design of an innovative magnetostrictive patch actuator

    Science.gov (United States)

    Cinquemani, S.; Giberti, H.

    2015-04-01

    Magnetostrictive actuators can be profitably used to reduce vibration in structures. However, this technology has been exploited only to develop inertial actuators, while patches actuators have not been ever used in practice. Patches actuators consist on a layer of magnetostrictive material, which has to be stuck to the surface of the vibrating structure, and on a coil surrounding the layer itself. However, the presence of the winding severely limits the use of such devices. As a matter of fact, the scientific literature reports only theoretical uses of such actuators, but, in practice it does not seem they were ever used. This paper presents an innovative solution to improve the structure of the actuator patches, allowing their use in several practical applications. The principle of operation of these devices is rather simple. The actuator patch is able to generate a local deformation of the surface of the vibrating structure so as to introduce an equivalent damping that dissipates the kinetic energy associated to the vibration. This deformation is related to the behavior of the magnetostrictive material immersed in a variable magnetic field generated by the a variable current flowing in the winding. Contrary to what suggested in the theoretical literature, the designed device has the advantage of generating the variable magnetic field no longer in close proximity of the material, but in a different area, thus allowing a better coupling. The magnetic field is then conveyed through a suitable ferromagnetic structure to the magnetostrictive material. The device has been designed and simulated through FEA. Results confirm that the new configuration can easily overcome all the limits of traditional devices.

  19. Broadband Circularly Polarized Patch Antenna and Method

    Science.gov (United States)

    2016-09-16

    embodiment further includes a series of coupling layers 24A, 24B and 24C of low dielectric constant spacers 26 and parallel high dielectric constant...as that used to make a printed circuit board. [0005] A common means of obtaining a circularly polarized signal from a rectangular patch antenna of...in a single plane, coplanar with the emitter, and parallel to the dominant current distribution when the emitter is active. Further coupling layers

  20. Microwave array applicator for radiometry-controlled superficial hyperthermia

    Science.gov (United States)

    Stauffer, Paul R.; Jacobsen, Svein; Neuman, Daniel

    2001-06-01

    Hyperthermia therapy has been shown clinically effective for a variety of skin diseases but current heating equipment is inadequate for most patients. This effort describes the design and performance of a flexible microstrip array applicator intended for heating large regions of tissue over contoured anatomy while at the same time monitoring temperature of the underlying tissue by non-invasive radiometric sensing of blackbody radiation from the heated volume. For this dual purpose applicator, an array of broadband Archimedean spiral receive antennas is integrated into an array of Dual Concentric Conductor heating apertures. Applicator heating uniformity is assessed with electric field scans in homogenous muscle phantoms and with measured temperature distributions in clinical treatments of chestwall recurrence of breast carcinoma. The data demonstrate precisely controlled heating out to the perimeter of large (40 x 13 cm2) multiaperture conformal array applicators. Capabilities of the radiometry system are assessed by correlation of brightness temperatures measured in phantom loads of known temperature distribution as seen through an intervening 5 mm thick water bolus at constant 40°C. The radiometer demonstrates excellent sensitivity and an accuracy of +0.1-0.45°C for temperature measurements up to 5 cm deep in phantom when using a one dimensional weighting function analysis and up to 6 independent 500 MHz bandwidths within the 1-4 GHz range. The data clearly indicate that both heating and radiometric thermometry are possible using the same thin and flexible printed circuit board microstrip array applicator. Once development is complete, this dual mode conformal array applicator with multiplexed radiometric display system should provide significantly improved uniformity and ease of heating large area superficial tissue disease.

  1. UV radiation sensors with unitary and binary superficial barrier

    Science.gov (United States)

    Dorogan, Valerian; Vieru, Tatiana; Kosyak, V.; Damaskin, I.; Chirita, F.

    1998-07-01

    UV radiation sensors with unitary and binary superficial barrier, made on the basis of GaP - SnO2 and GaAs - AlGaAs - SnO2 heterostructures, are presented in the paper. Technological and constructive factors, which permit to realize a high conversion efficiency and to exclude the influence of visible spectrum upon the photoanswer, are analyzed. It was established that the presence of an isotypical superficial potential barrier permits to suppress the photoanswer component formed by absorption of visible and infrared radiation in semiconductor structure bulk.

  2. PHOTODYNAMIC DIAGNOSIS AND FLUORESCENCE SPECTROSCOPY IN SUPERFICIAL BLADDER CANCER

    Directory of Open Access Journals (Sweden)

    I. G. Rusakov

    2009-01-01

    Full Text Available A comprehensive fluorescence technique has been developed to study the urinary bladder mucosa in patients with superficial bladder cancer (BC, by using alasense, white light cystoscopy, fluorescence cytoscopy, and local fluorescence spectroscopy in vivo. Quantification of urothelium fluorescence in the red emission foci of 5-ALA-induced protophorphyrin, with the local autofluorescence intensity being borne in mind, has been shown to increase the specificity of photodynamic diagnosis of superficial BC from 70 to 85% (p ≤ 0.05 and the total accuracy of the technique from 80 to 86%.  

  3. Aortic aneurysm after patch aortoplasty for coarctation: analysis of patch size and wall growth.

    Science.gov (United States)

    Al-Hroob, A; Husayni, T S; Freter, A; Chiemmongkoltip, P; Ilbawi, M N; Arcilla, R A

    2003-01-01

    Aortic aneurysm may develop after surgery for coarctation of aorta especially patch aortoplasty. The size of patch and of adjacent native aortic wall was analyzed to determine whether aortic dilatation represents a true aneurysm. Electron beam tomography (EBT) was done on 19 patients, three months to 17.5 years after patch aortoplasty. Tomograms of aorta were obtained in 6-mm slices, and maximal cross-sectional area was digitized to obtain: total circumference (Ct), patch component (Cp), and aortic wall component (Cw). Ct, Cp, and Cw were normalized to the circumference of distal aorta (Cda) as: isthmus/distal aorta (Ct/Cda), patch segment/distal aorta (Cp/Cda), wall segment/distal aorta (Cw/Cda). Ct/Cda ranged from 109% to 260%. In 12 patients (group A), it varied from 168% to 260%; and in seven (group B), 109% to 133%. There was strong correlation (r = 0.92) between Ct/Cda and Cp/Cda. Ct/Cda, Cp/Cda, and Cp/Cw were higher in group A than B (p <0.001) but Cw/Cda did not differ. Cw/Cda was greater than the coarctation/distal aorta diameter ratios of preoperative angiograms, consistent with accelerated aortic wall growth postsurgery. No definite aneurysm was seen. Localized dilatation of aorta following patch aortoplasty in children is primarily due to a large synthetic patch and, partly, to increased aortic wall growth. Serial EBT or magnetic resonance imaging is indicated to monitor aortic wall growth and occurrence of aneurysm.

  4. Optimal patch code design via device characterization

    Science.gov (United States)

    Wu, Wencheng; Dalal, Edul N.

    2012-01-01

    In many color measurement applications, such as those for color calibration and profiling, "patch code" has been used successfully for job identification and automation to reduce operator errors. A patch code is similar to a barcode, but is intended primarily for use in measurement devices that cannot read barcodes due to limited spatial resolution, such as spectrophotometers. There is an inherent tradeoff between decoding robustness and the number of code levels available for encoding. Previous methods have attempted to address this tradeoff, but those solutions have been sub-optimal. In this paper, we propose a method to design optimal patch codes via device characterization. The tradeoff between decoding robustness and the number of available code levels is optimized in terms of printing and measurement efforts, and decoding robustness against noises from the printing and measurement devices. Effort is drastically reduced relative to previous methods because print-and-measure is minimized through modeling and the use of existing printer profiles. Decoding robustness is improved by distributing the code levels in CIE Lab space rather than in CMYK space.

  5. Thermal study of a residential water solar heating system with two different absorbing surface configurations; Estudo termico de um sistema solar de aquecimento de agua residencial para duas configuracoes de superficie absorvedora

    Energy Technology Data Exchange (ETDEWEB)

    Abreu, Rivaldo Ferreira

    2009-10-15

    A solar collector to be used in a system for heating water for bathing, whose main characteristics are its low cost and easy manufacturing and assembly is presented. The absorbing surface of the collector is formed by an aluminum plate with eight flaps where they lodge PVC pipes. The catchment area of solar radiation corresponds to 1.3 meters. The collector box was made of wood, it is covered by transparent glass and thermal insulation of tire chips and expanded polystyrene (EPS). Absorber tubes were connected in parallel through the use of PVC fittings and fixed to the plate by the use of metal poles and rivets. The entire absorber received paint fiat black for better absorption of sunlight. The system worked on a thermosyphon assembly and absorber of the collector has been tested in two configurations: with the tubes facing up, directly exposed to the impact of sunlight and facing down, exchanging heat with the plate by conduction. The most efficient configuration for the connect purpose was determined. The solar collector was connected to a thermal reservoir, also alternative, low-cost forming the system of solar water heating. We evaluated thermal parameters that proved the viability of the heating system studied. (author)

  6. Study on the Valuation System for the Superficial Characteristics of the Rat Models with Heat-deficiency Syndrome Based on PLS%基于PLS的虚热证大鼠模型表征评价体系的研究

    Institute of Scientific and Technical Information of China (English)

    韩冰冰; 王世军; 张发艳; 王媛; 张亚楠

    2012-01-01

    Objective: To discuss the valuation system for superficial characteristics of rat models with heat-deficiency syndrome in ac-cordance with the theory of traditional Chinese medicine by PLS data analysis. Methods;Rat models with heat-deficiency syndrome were established by compound preparation of Aconitum carmichaeli, Cinnamomi Cortex and Rhizoma Zingiberis. After the models were cop-ied, superficial characteristics such as body temperature, ordinary situation, cold and warm tendency, autonomy activities and metabolism energy were tested and the data were estimated by PLS. Results: Rat models of heat-deficiency syndrome were significantly influenced by stool texture and colors, average toe temperature, body weight, rectal temperature, metabolic energy to unit weight and activity state (VIP > 1). Conclusion;The main symptoms and signs of animal models with heat-deficiency syndrome are consistent with the clinical diagnosis of heat-deficiency syndrome, which reflects the pathological features of "yin-deficiency and endogenous heat" of heat-deficien-cy syndrome.%目的:探讨采用偏最小二乘回归(PLS)法对符合虚热证动物模型表征评价体系进行研究.方法:使用中药复方附子、干姜、肉桂建立虚热证大鼠模型,检测体温、一般状况、寒热趋向、自主活动及代谢能等表征,PLS法建立回归模型,并进行数据分析.结果:粪质地、粪色、平均趾温、体质量、肛温、单位体质量可代谢能、活动状态对模型有重要影响力(VIP>1).结论:虚热证模型动物的主要症状及体征与虚热证的临床诊断基本相符,体现了虚热证阴虚内热的病理特点.

  7. Investigation of fluorine-doped tin oxide based optically transparent E-shaped patch antenna for terahertz communications

    Energy Technology Data Exchange (ETDEWEB)

    Anand, S., E-mail: anand.s.krishna@gmail.com, E-mail: darak.mayur@gmail.com, E-mail: srk@nitt.edu; Darak, Mayur Sudesh, E-mail: anand.s.krishna@gmail.com, E-mail: darak.mayur@gmail.com, E-mail: srk@nitt.edu; Kumar, D. Sriram, E-mail: anand.s.krishna@gmail.com, E-mail: darak.mayur@gmail.com, E-mail: srk@nitt.edu [Department of Electronics and Communication Engineering, National Institute of Technology, Tiruchirappalli 620015 (India)

    2014-10-15

    In this paper, a fluorine-doped tin oxide based optically transparent E-shaped patch antenna is designed and its radiation performance is analyzed in the 705 – 804 GHz band. As optically transparent antennas can be mounted on optical display, they facilitate the reduction of overall system size. The proposed antenna design is simulated using electromagnetic solver - Ansys HFSS and its characteristics such as impedance bandwidth, directivity, radiation efficiency and gain are observed. Results show that the fluorine-doped tin oxide based optically transparent patch antenna overcomes the conventional patch antenna limitations and thus the same can be used for solar cell antenna used in satellite systems.

  8. Urodeles remove mesoderm from the superficial layer by subduction through a bilateral primitive streak.

    Science.gov (United States)

    Shook, David R; Majer, Christina; Keller, Ray

    2002-08-15

    Urodeles begin gastrulation with much of their presumptive mesoderm in the superficial cell layer, all of which must move into the deep layers during development. We studied the morphogenesis of superficial mesoderm in the urodeles Ambystoma maculatum, Ambystoma mexicanum, and Taricha granulosa. In all three species, somitic, lateral, and ventral mesoderm move into the deep layer during gastrulation, ingressing through a "bilateral primitive streak" just inside the blastopore. The mesodermal epithelium appears to slide under the endodermal epithelium by a mechanism we term "subduction." Subduction removes the large expanse of superficial presumptive somitic and lateral-ventral mesoderm that initially separates the sub-blastoporal endoderm from the notochord, leaving the endoderm bounding the still epithelial notochord along the gastrocoel roof. Subduction may be a common feature of urodele gastrulation, differing in this regard from anurans. Subducting cells constrict their apices and become bottle-shaped as they approach the junction of the mesodermal and endodermal epithelia. Subducting bottle cells endocytose apical membrane and withdraw the tight junctional component cingulin from the contracting circumferential tight junctions. Either in conjunction with or immediately after subducting, the mesodermal cells undergo an epithelial-to-mesenchymal transition. The mechanism by which epithelial cells release their apical junctions to become mesenchymal, without disrupting the integrity of the epithelium, remains mysterious, but this system should prove useful in understanding this process in a developmental context.

  9. Development of an omni-directional shear-horizontal wave magnetostrictive patch transducer for plates.

    Science.gov (United States)

    Seung, Hong Min; Kim, Hoe Woong; Kim, Yoon Young

    2013-09-01

    As an effective tool to inspect large plates, omni-directional guided wave transducers have become more widely used to form phased-array inspection systems. While omni-directional Lamb wave transducers have been successfully utilized in the systems, omni-directional Shear-Horizontal (SH) wave transducers have not been investigated. In this paper, we propose an omni-directional SH magnetostrictive patch transducer that consists of an annular magnetostrictive patch, a toroidal coil and a permanent magnet. After presenting the unique configuration of the proposed transducer and its working principle, the omni-directivity of the developed transducer is verified through simulations and experiments conducted in an aluminum plate. The frequency characteristics of the proposed transducer depending on the patch size are also investigated as the underlying reference data for future construction of an SH phased-array system.

  10. Lecture 11: Systemtap : Patching the linux kernel on the fly

    CERN Document Server

    CERN. Geneva

    2013-01-01

    The presentation will describe the usage of Systemtap, in CERN Scientific Linux environment. Systemtap is a tool that allows developers and administrators to write and reuse simple scripts to deeply examine the activities of a live Linux system. We will go through the life cycle of a system tap module : creation, packaging, deployment. It will focus on how we used it recently at CERN as a workaround to patch a 0-day. Thomas Oulevey is a member if the IT department at CERN where he is an active member of the Linux team which supports 9’000 servers, 3’000 desktop systems and more than 5’000 active users. Before CERN he worked at the former astrophysics department of CERN, now called the European Southern Observatory, based in Chile. He was used to maintain the core telescope Linux systems and monitoring infrastructure.

  11. Miniaturization of Multiple-Layer Folded Patch Antennas

    DEFF Research Database (Denmark)

    Zhang, Jiaying; Breinbjerg, Olav

    2009-01-01

    A new folded patch antenna with multiple layers was developed in this paper, by folding the patch in a proper way, and a highly miniaturized antenna can be realized. The multiple layer patch with 4-layer and 6-layer are designed and evaluated at 2.4 GHz, 915 MHz, and 415 MHz respectively. Then a 4...... layer patch is fabricated and measured to validate the design method. The theoretical analysis, design and simulations, fabrications, as well as the measurements are presented in this paper. All the results show that the folded patch antenna is a good candidate in making a highly miniaturized compact...... antenna....

  12. Retrospective evaluation of the consequence of alleged patch test sensitization

    DEFF Research Database (Denmark)

    Jensen, Charlotte D; Paulsen, Evy; Andersen, Klaus E

    2006-01-01

    consequences in cases of possible patch test sensitization. Among 7619 consecutively tested eczema patients in a 14-year period 26 (0.3%) were identified in the database as having had a late patch test reaction, which may be an indication of patch test sensitization. 9 of these cases were not suitable....... For the remaining 11 patients we could not rule out that they were patch test sensitized, and they were investigated further. 1 was diseased and 10 were interviewed regarding the possible consequences of the alleged patch test sensitization. 9 had not experienced any dermatitis problems, and 1 could not exclude...

  13. Single image super-resolution based on image patch classification

    Science.gov (United States)

    Xia, Ping; Yan, Hua; Li, Jing; Sun, Jiande

    2017-06-01

    This paper proposed a single image super-resolution algorithm based on image patch classification and sparse representation where gradient information is used to classify image patches into three different classes in order to reflect the difference between the different types of image patches. Compared with other classification algorithms, gradient information based algorithm is simpler and more effective. In this paper, each class is learned to get a corresponding sub-dictionary. High-resolution image patch can be reconstructed by the dictionary and sparse representation coefficients of corresponding class of image patches. The result of the experiments demonstrated that the proposed algorithm has a better effect compared with the other algorithms.

  14. A Pragmatic Approach to Patch Testing Atopic Dermatitis Patients

    DEFF Research Database (Denmark)

    Chen, Jennifer K; Jacob, Sharon E; Nedorost, Susan T

    2016-01-01

    Allergic contact dermatitis (ACD) may complicate the clinical course of atopic dermatitis (AD), and patch testing remains the criterion standard for diagnosing ACD. To date, there have been no guidelines or consensus recommendations on when and how to patch test individuals with AD. Failure...... to patch test when appropriate may result in overlooking an important and potentially curable complicating comorbidity. In this article, we present consensus recommendations regarding when to perform patch testing in the AD patient, best practices, and common pitfalls. Patch testing should be considered...

  15. Determination of surface dose rate of indigenous (32)P patch brachytherapy source by experimental and Monte Carlo methods.

    Science.gov (United States)

    Kumar, Sudhir; Srinivasan, P; Sharma, S D; Saxena, Sanjay Kumar; Bakshi, A K; Dash, Ashutosh; Babu, D A R; Sharma, D N

    2015-09-01

    Isotope production and Application Division of Bhabha Atomic Research Center developed (32)P patch sources for treatment of superficial tumors. Surface dose rate of a newly developed (32)P patch source of nominal diameter 25 mm was measured experimentally using standard extrapolation ionization chamber and Gafchromic EBT film. Monte Carlo model of the (32)P patch source along with the extrapolation chamber was also developed to estimate the surface dose rates from these sources. The surface dose rates to tissue (cGy/min) measured using extrapolation chamber and radiochromic films are 82.03±4.18 (k=2) and 79.13±2.53 (k=2) respectively. The two values of the surface dose rates measured using the two independent experimental methods are in good agreement to each other within a variation of 3.5%. The surface dose rate to tissue (cGy/min) estimated using the MCNP Monte Carlo code works out to be 77.78±1.16 (k=2). The maximum deviation between the surface dose rates to tissue obtained by Monte Carlo and the extrapolation chamber method is 5.2% whereas the difference between the surface dose rates obtained by radiochromic film measurement and the Monte Carlo simulation is 1.7%. The three values of the surface dose rates of the (32)P patch source obtained by three independent methods are in good agreement to one another within the uncertainties associated with their measurements and calculation. This work has demonstrated that MCNP based electron transport simulations are accurate enough for determining the dosimetry parameters of the indigenously developed (32)P patch sources for contact brachytherapy applications.

  16. Interpolación y ajuste de superficies en componentes mecánicos digitalizados empleando superficies B-Spline

    OpenAIRE

    2014-01-01

    Este documento de tesis tiene el propósito de describir una metodología para obtener nubes de puntos que representen a superficies (o parches de geometría compleja) de piezas mecánicas que pueden ser replicadas en la industria. Estos puntos se obtuvieron utilizando el método de interpolación superficial B-Spline que deben cumplir un margen de error conocido y controlado de acuerdo a las tolerancias de fabricación utilizados en estos procesos de fabricación. En primer lugar e...

  17. Coupled Human-Environment Dynamics of Forest Pest Spread and Control in a Multi-Patch, Stochastic Setting.

    Directory of Open Access Journals (Sweden)

    Qasim Ali

    Full Text Available The transportation of camp firewood infested by non-native forest pests such as Asian long-horned beetle (ALB and emerald ash borer (EAB has severe impacts on North American forests. Once invasive forest pests are established, it can be difficult to eradicate them. Hence, preventing the long-distance transport of firewood by individuals is crucial.Here we develop a stochastic simulation model that captures the interaction between forest pest infestations and human decisions regarding firewood transportation. The population of trees is distributed across 10 patches (parks comprising a "low volume" partition of 5 patches that experience a low volume of park visitors, and a "high volume" partition of 5 patches experiencing a high visitor volume. The infestation spreads within a patch--and also between patches--according to the probability of between-patch firewood transportation. Individuals decide to transport firewood or buy it locally based on the costs of locally purchased versus transported firewood, social norms, social learning, and level of concern for observed infestations.We find that the average time until a patch becomes infested depends nonlinearly on many model parameters. In particular, modest increases in the tree removal rate, modest increases in public concern for infestation, and modest decreases in the cost of locally purchased firewood, relative to baseline (current values, cause very large increases in the average time until a patch becomes infested due to firewood transport from other patches, thereby better preventing long-distance spread. Patches that experience lower visitor volumes benefit more from firewood movement restrictions than patches that experience higher visitor volumes. Also, cross-patch infestations not only seed new infestations, they can also worsen existing infestations to a surprising extent: long-term infestations are more intense in the high volume patches than the low volume patches, even when

  18. EX1101: Ship Shakedown and Patch Tests on NOAA Ship Okeanos Explorer between March 16 and April 1, 2011

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project will involve the shakedown of all Okeanos Explorer ship capabilities and a patch test of the Kongsberg EM302 multibeam system. Operations for this...

  19. Shear bond strength of two bonding systems on dentin surfaces prepared with Er:YAG laser; Resistencia de uniao ao cisalhamento de dois sistemas adesivos em superficies dentinarias preparadas com laser de Er:YAG

    Energy Technology Data Exchange (ETDEWEB)

    Dall' Magro, Eduardo

    2001-07-01

    The purpose of this study was to examine the shear bond strength of two bonding dentin systems, one 'one step' (Single Bond - 3M) and one 'self-etching' (Prompt-L-ESPE), when applied on dentin surfaces prepared with Er:YAG laser (2,94{mu}m) that underwent ar not, acid etched. Forty one human molars just extracted were selected and after the cut with diamond disc and included in acrylic resin, resulting in 81 specimens (hemi crowns). After, the specimens were divided in one group treated with sand paper and another two groups treated with Er:YAG laser with 200 mJ and 250 mJ of energy and 2 Hz of frequency. Next, the prepared surfaces received three treatments with following application: 1) acid + Single Bond + Z 250 resin, 2) prompt-L-Pop + Z 250 resin, and 3) acid without, Single Bond + Z 250 resin. The Z 250 resin was applied and photopolymerized in increments on a Teflon matrix that belonged to an apparatus called 'Assembly Apparatus' machine producing cylinders of 3,5 mm of diameter and 5 mm of height. After these specimens were submitted to thermo cycling during 1 minute the 55 deg C and during 1 minute with 5 deg C with a total of 500 cycles for specimen, and the measures of shear bond strength were abstained using EMIC model DL 2000 rehearsed machine, with speed of 0,5 mm/min, measuring the final rupture tension (Mpa). The results showed an statistic superiority of 5% of probability level in dentin flattened with sandpaper and with laser using 200 mJ of energy with aspect to the ones flattened with laser using 250 mJ of energy. It was observed that using 'Single Bond' bonding dentin system the marks were statistically superior at 5% of probability with reference to the use of the Prompt-L-Pop adhesive system. So, it was concluded that Er:YAG Laser with 200 mJ of energy produced similar dentin cavity prepare than sandpaper and Single Bond seemed the best bonding agent system between restorative material and dentin

  20. TRANSDERMAL PATCHES: PHYSIOCHEMICAL AND IN-VITRO EVALUATION METHODS

    Directory of Open Access Journals (Sweden)

    Rishabh Bahl

    2015-05-01

    Full Text Available Various drugs are available these days, which may either require long term administration via multiple doses or may be susceptible to enzymes and first pass-metabolism or all the above. One way to administer such drugs is through the transdermal route. After a transdermal delivery system is designed, it is important to evaluate it for various essential parameters that help us determine how effective it is, i.e. its physiochemical parameters, which describe the physical and some of the chemical properties of the patch and it’s in-vitro parameters, which would mimic how the patch would behave on exposure to real time conditions On the body. This article briefly reviews the ideal characters for choosing this mode of drug delivery, its advantages and provides an in-depth analysis of the techniques used to physio-chemically evaluate the delivery system’s important parameters and also the conditions that help understand the systems behavior in a real time scenario.

  1. How geomorphology and groundwater level affect the spatio-temporal variability of riverine cold water patches?

    Science.gov (United States)

    Wawrzyniak, Vincent; Piégay, Hervé; Allemand, Pascal; Vaudor, Lise; Goma, Régis; Grandjean, Philippe

    2016-04-01

    Temperature is a key factor for river ecosystems. In summer, patches of cold water are formed in the river by groundwater seepage. These patches have strong ecological significance and extend to the surface water in a well-mixed riverine system. These patches can serve as thermal refuges for some fish species during summer. In this study, the temporal variability and spatial distribution of cold water patches were explored along a 50 km river reach (the lower Ain River, France) using thermal infrared airborne remote sensing. This study examines a new range of processes acting on cold water patches at different scales that have not previously been touched upon in the literature. Three airborne campaigns were conducted during the summers of 2010, 2011 and 2014. Based on these images, a large number of cold water patches were identified using an automated method. Four types of patches were observed: tributary plumes, cold side channels (former channels or point-bar backwater channels), side seeps (located directly in the river channel) and gravel bar seeps (occurring at the downstream end of gravel bars). Logistic regression was used to analyse the longitudinal distribution of cold water patches according to geomorphologic indicators reflecting current or past fluvial process. Side seeps were found to be related to the local geology. Cold side channels were correlated to contemporary and past lateral river mobility. Gravel bar seeps were related to the current development of bars and are more prevalent in wandering reaches than in single-bed incised and paved reaches. The logistic model was subsequently used to evaluate gravel bar seep variability in the past. The model suggests larger numbers of seeps in the mid-20th century when bar surface area was higher. Interannual variability in the occurrence and spatial extent of side seeps and gravel bar seeps appear to be related to groundwater level fluctuations. Cold side channels exhibited greater interannual stability

  2. Movement of patches during thermoforming: Experiment and simulation

    Science.gov (United States)

    Schell, J. S. U.; Amory, L.; Guillon, D.

    2016-10-01

    The application of local reinforcement like uni-directional patches can locally increase the strength of composite parts without adding much weight. During design through structural analysis, shape and position of local reinforcement can easily be determined. In the thermoforming process, patches can be integrated into the ply-stack by preassembling. During forming, these patches can move and change their position reducing the structural effect of the patch. The movement of patches has been investigated experimentally. Key factors that influence this movement are orientation, size, position in the pile and slope of the mold. The forming process is simulated using HYPERFORM. The results show that this complex process needs special models which can be computationally intensive. In this work, we model the movement of patches and compare with experiments. The final goal is to have a reasonable predictive capability for movement of patches and design the process to minimize it.

  3. A Latent Source Model for Patch-Based Image Segmentation.

    Science.gov (United States)

    Chen, George H; Shah, Devavrat; Golland, Polina

    2015-10-01

    Despite the popularity and empirical success of patch-based nearest-neighbor and weighted majority voting approaches to medical image segmentation, there has been no theoretical development on when, why, and how well these nonparametric methods work. We bridge this gap by providing a theoretical performance guarantee for nearest-neighbor and weighted majority voting segmentation under a new probabilistic model for patch-based image segmentation. Our analysis relies on a new local property for how similar nearby patches are, and fuses existing lines of work on modeling natural imagery patches and theory for nonparametric classification. We use the model to derive a new patch-based segmentation algorithm that iterates between inferring local label patches and merging these local segmentations to produce a globally consistent image segmentation. Many existing patch-based algorithms arise as special cases of the new algorithm.

  4. Diagnostic and therapeutic challenges in superficial CNS siderosis

    DEFF Research Database (Denmark)

    Kondziella, Daniel; Lindelof, M.; Haziri, Donika

    2015-01-01

    that neurodegeneration due to haemosiderin-associated iron toxicity becomes irreversible with time. CONCLUSION: Surgical therapy in superficial CNS siderosis is rarely achieved. We suggest that prospective, large-scale multicentre studies are needed to search for non-surgical therapies that reverse (or prevent) ongoing...... neurotoxicity due to accumulating iron toxicity. FUNDING: not relevant. TRIAL REGISTRATION: not relevant....

  5. Anterior urethral recurrence of superficial bladder cancer: its clinical significance.

    Directory of Open Access Journals (Sweden)

    Saika T

    2003-12-01

    Full Text Available The aim of this study was to reveal the clinical features of anterior urethral recurrence in patients with superficial bladder cancer, and to determine the appropriate treatment. Three hundred and three patients with superficial bladder cancer, who were newly diagnosed and initially treated conservatively in our hospital between 1965 and 1990, were followed for at least 5 years and their clinical outcomes were analyzed. Clinical factors, including anterior urethral recurrence, were evaluated statistically regarding tumor progression. Eight patients (2.6% had anterior urethral recurrence following superficial bladder cancer. Twenty-four patients (7.9% had tumor progression and 149 (49.2% had tumor recurrence. In a multivariate analysis using a logistic model, anterior urethral recurrence was the most important factor, followed by histological grade. Four of 5 patients who were treated for anterior urethral recurrent tumors by transurethral resection showed progression and died of the cancer within one year. Two of the remaining three patients who underwent radical cysto-urethrectomy at the time of anterior urethral recurrence survived. Anterior urethral recurrence following superficial bladder cancer is a predictor for rapid subsequent malignant progression. Once there is anterior urethral recurrence, radical intensive therapy, including radical cysto-urethrectomy, should be carried out immediately.

  6. Superficies bioactivas en implantología: una nueva perspectiva

    Directory of Open Access Journals (Sweden)

    A. Cutando

    2007-02-01

    Full Text Available Actualmente, tras años de investigación en implantología, en los cuales se han realizado muchos trabajos, en donde se han estudiado diferentes tipos de superficies de implantes, lisas y rugosas, en un intento de mejorar, tanto en el tiempo como en la calidad , la osteointegración, se ha concluido que los implantes de superficie rugosa con un intervalo de rugosidad entre 1,0-2,0 nm, son los que parecen dar una mejor respuesta ósea y mejores resultados clínicos, pero desde un punto de vista exclusivamente mecánico. Hoy en día las investigaciones se centran en el desarrollo de superficies denominadas bioactivas, las cuales son capaces de interaccionar con el hueso que rodea al implante, como ocurre cuando el implante es revestido con carbonato cálcico o bien con flúor. Pero sabemos que dentro del metabolismo óseo, juegan importantes papeles, moléculas, como son la melatonina y la hormona del crecimiento entre otras, las cuales deben de ser tenidas en cuenta a la hora de hablar de osteointegración. Se realiza una breve descripción de la fisiología de ambas moléculas y se valora su aplicación al concepto de superficie bioactiva en implantología.

  7. Superficial Needling Therapy for Tennis Elbow in 40 Cases

    Institute of Scientific and Technical Information of China (English)

    GE Heng-bi; XIAO Yuan-chun

    2003-01-01

    Superficial needling therapy was employed to treat 40 cases of tennis elbow. For the cases of qi and blood stagnation, cupping therapy was added. Thirty-eight cases were cured after one treatment and 2 cases were cured after two treatments.

  8. Frey′s Syndrome as a Sequela of Superficial Parotidectomy

    Directory of Open Access Journals (Sweden)

    Rishi Kumar Bali

    2006-01-01

    The disorder is characterized by unilateral sweating and flushing of facial skin in the area of parotid gland occurring during meals. We present a case of a patient who developed symptoms of Frey Syndrome 4 months after undergoing superficial parotidectomy on left side.

  9. Atypical Presentation of Fibrolipomatous Hamartoma of Superficial Peroneal Nerve.

    Science.gov (United States)

    Dhinsa, Baljinder Singh; Lidder, Surjit; Abbasian, Ali

    2016-01-01

    Fibrolipomatous hamartoma is a rare presentation in the foot. An accurate diagnosis is key, with magnetic resonance imaging findings considered definitive. The management is dependent on the symptoms. We present an atypical presentation of fibrolipomatous hamartoma of the superficial peroneal nerve and discuss the current published data.

  10. Superficial dermatomycoses: a prospective clinico-mycological study

    Directory of Open Access Journals (Sweden)

    Surekha A

    2015-01-01

    Full Text Available Background: Dermatomycoses are more prevalent in India due to favourable climatic conditions, poverty, poor hygiene and overcrowding. Sparse published data are available regarding superficial dermatomycoses from India. Methods: In this prospective study, demographic characteristics, clinical spectrum and risk factors for the development were studied in 198 patients with superficial dermatomycoses. Results: Their mean age was 34.1 ± 15.3 years; there were 108 (54.5% males. Majority of the patients (50.5% belonged to upper-lower socio-economic status (Class IV as per modified Kuppuswamy’s classification. Most of the patients (69.7% had presented with dermatophytoses. Among superficial dermatomy-coses, tinea corporis was the most common (29.3% clinical type. Potassium hydroxide mount was positive in 77.7% and culture was positive in 30.8%. Trichophyton rubrum was the most common species isolated (64%. Multivariable analysis using logistic regression revealed older age (> 50 years to be an independent predictor for the development of tinea corporis (p<0.001. Conclusions: Our observations suggest that superficial dermatomycoses are an important cause of morbidity and should be carefully searched for especially in the elderly so that effective curative treatment can be instituted.

  11. Tattoo removal by superficial dermabrasion. Five-year experience.

    Science.gov (United States)

    Clabaugh, W A

    1975-04-01

    A 5-year clinical experience using superficial dermabrasion to remove tattoos is presented. This procedure can be done quickly in the office with low patient risk. Good pigment removal is obtained with little or no scar formation. Cases are presented which are typical of the 250 tattoos removed in the last 5 years.

  12. Analysis of the evaluation of the Lab chromatic system on the result of nickel sulfate patch test%L��a��b��色度系统评估硫酸镍斑贴试验结果分析

    Institute of Scientific and Technical Information of China (English)

    杨素莲; 尹颂超; 张云青; 叶聪秀; 易金玲; 谢淑霞; 赖维

    2015-01-01

    Objective To understand the effects of the different results of nickel sulfate patch test on the L*a *b *chromatic system. Methods The occlusive human nickel sulfate patch test was in 38 healthy volunteers.The 2.5%nickel sulfate patch test was tapped on the back of the volunteers for 24 hours.Measurements including clinical evaluation and the determination of L*a *b *were made before patch occlusion and 0.5h(D1),24h(D2) after patch removal, respectively. Results In all 38 subjects, 8 cases were judged positive at D1 and (or) D2.There was no significant difference between positive group an negative group in the values of L**b *and a*at D1 and D2. The a*values of positive goup at D1, D2 were 10.64±1.90,13.22±1.92 respectively, which both were higher than the value 7.80±2.49 before patch test (P=0.000). Conclusion In the contact dermatitis model inducing by nickel sulfate, the a*val⁃ue of the L*a *b *chromatic system can reflect erythematic changes after skin inflammation, showing a*value maybe the objective evaluation parameter to evaluate contact dermatitis.%目的:了解硫酸镍斑贴试验不同结果对L��a��b��色度系统变化的影响。方法:对38名健康志愿者进行人体皮肤封闭型硫酸镍斑贴试验。将2.5%硫酸镍斑试器用胶带贴敷在受试者上背部,同时设空白对照,封包24h后揭去斑试物。分别于试验前(D0)、揭去斑试物后0.5h(D1)、24h(D2)对皮肤反应结果进行临床评估及皮肤颜色L��a��b��值测定。结果:38例受试者中8例在D1和(或)D2时临床评估为阳性。镍斑贴试验阴性组、空白对照组受试者D1、D2时皮肤色度L��值、b��值及a��值较D0均无明显变化;斑贴试验阳性组D1、D2时皮肤色度a��值分别为10.64±1.90和13.22±1.92,较D0时皮肤色度a��值7.80±2.49明显升高(P=0.000)。结论:硫酸镍斑贴诱发的接触性皮炎模型中,L��a��b��色度系统a

  13. Formulation Design and Development of a Unani Transdermal Patch for Antiemetic Therapy and Its Pharmaceutical Evaluation

    Science.gov (United States)

    Idris, Mohammad

    2016-01-01

    The Transdermal Drug Delivery System (TDDS) is one of the novel routes for systemic delivery of drugs through intact skin. A transdermal patch (TP) is a medicated patch that is placed on skin for delivery of medication through skin into the blood stream. The aim of present study was to formulate and evaluate a Unani transdermal patch that could be used for antiemetic therapy. The incorporation of Unani ingredients, namely, Khardal (Brassica nigra), Zanjabeel (Zingiber officinale), Podina (Mentha arvensis), and Sirka (Vinegar) were envisaged. The TP was prepared by solvent evaporation technique and was evaluated for organoleptic characteristics and other physicochemical properties, such as thickness, weight uniformity, folding endurance, moisture content, drug content, and tolerability and acceptability of patch. The in vitro permeation study of the patch was carried out through Franz diffusion cell using egg shell membrane as barrier membrane. Phosphate buffer pH 7.4 was used as dissolution medium and the temperature was maintained at 37 ± 1°C. The in vitro permeation study of the prepared TP indicated a time dependent increase in drug release throughout the study. The percentage of cumulative drug release was found to be 77.38% in 24 hours. The study shows a new approach to work in Unani pharmaceutics. PMID:27403377

  14. Formulation Design and Development of a Unani Transdermal Patch for Antiemetic Therapy and Its Pharmaceutical Evaluation

    Directory of Open Access Journals (Sweden)

    Mohd Nauman Saleem

    2016-01-01

    Full Text Available The Transdermal Drug Delivery System (TDDS is one of the novel routes for systemic delivery of drugs through intact skin. A transdermal patch (TP is a medicated patch that is placed on skin for delivery of medication through skin into the blood stream. The aim of present study was to formulate and evaluate a Unani transdermal patch that could be used for antiemetic therapy. The incorporation of Unani ingredients, namely, Khardal (Brassica nigra, Zanjabeel (Zingiber officinale, Podina (Mentha arvensis, and Sirka (Vinegar were envisaged. The TP was prepared by solvent evaporation technique and was evaluated for organoleptic characteristics and other physicochemical properties, such as thickness, weight uniformity, folding endurance, moisture content, drug content, and tolerability and acceptability of patch. The in vitro permeation study of the patch was carried out through Franz diffusion cell using egg shell membrane as barrier membrane. Phosphate buffer pH 7.4 was used as dissolution medium and the temperature was maintained at 37 ± 1°C. The in vitro permeation study of the prepared TP indicated a time dependent increase in drug release throughout the study. The percentage of cumulative drug release was found to be 77.38% in 24 hours. The study shows a new approach to work in Unani pharmaceutics.

  15. Formulation of unidirectional release buccal patches of carbamazepine and study of permeation through porcine buccal mucosa

    Institute of Scientific and Technical Information of China (English)

    Parthasarathy Govindasamy; Bhaskar Reddy Kesavan; Jayaveera Korlakunta Narasimha

    2013-01-01

    Objective:To achieve transbuccal release of carbamazepine by loading in unidirectional release mucoadhesive buccal patches. Methods:Buccal patches of carbamazepine with unidirectional drug release were prepared using hydroxypropyl methyl cellulose, polyvinyl alcohol, polyvinyl pyrrolidone and ethyl cellulose by solvent casting method. Water impermeable backing layer (Pidilite® Biaxially-oriented polypropylene film) of patches provided unidirectional drug release. They were evaluated for thickness, mass uniformity, surface pH and folding endurance. Six formulations FA2, FA8, FA10, FB1, FB14 and FB16 (folding endurance above 250) were evaluated further for swelling studies, ex vivo mucoadhesive strength, ex vivo mucoadhesion time, in vitro drug release, ex vivo permeation, accelerated stability studies and FTIR and XRD spectral studies. Results: The ex vivo mucoadhesion time of patches ranged between 109 min (FA10) to 126 min (FB14). The ex vivo mucoadhesive force was in the range of 0.278 to 0.479 kg/m/s. The in vitro drug release studies revealed that formulation FA8 released 84%and FB16 released 99.01%of drug in 140 min. Conclusions: The prepared unidirectional buccal patches of carbamazepine provided a maximum drug release within specified mucoadhesion period and it indicates a potential alternative drug delivery system for systemic delivery of carbamazepine.

  16. Electrocardiographic Patch Devices and Contemporary Wireless Cardiac Monitoring

    Directory of Open Access Journals (Sweden)

    Erik eFung

    2015-05-01

    Full Text Available Cardiac electrophysiologic derangements often coexist with disorders of the circulatory system. Capturing and diagnosing arrhythmias and conduction system disease may lead to a change in diagnosis, clinical management and patient outcomes. Standard 12-lead electrocardiogram (ECG, Holter monitors and event recorders have served as useful diagnostic tools over the last few decades. However, their shortcomings are only recently being addressed by emerging technologies. With advances in device miniaturization and wireless technologies, and changing consumer expectations, wearable ‘on-body’ ECG patch devices have evolved to meet contemporary needs. These devices are unobtrusive and easy to use, leading to increased device wear time and diagnostic yield. While becoming the standard for detecting arrhythmias and conduction system disorders in the outpatient setting where continuous ECG monitoring in the short to medium term (days to weeks is indicated, these cardiac devices and related digital mobile health technologies are reshaping the clinician-patient interface with important implications for future healthcare delivery.

  17. Major Superficial White Matter Abnormalities in Huntington's Disease

    Science.gov (United States)

    Phillips, Owen R.; Joshi, Shantanu H.; Squitieri, Ferdinando; Sanchez-Castaneda, Cristina; Narr, Katherine; Shattuck, David W.; Caltagirone, Carlo; Sabatini, Umberto; Di Paola, Margherita

    2016-01-01

    Background: The late myelinating superficial white matter at the juncture of the cortical gray and white matter comprising the intracortical myelin and short-range association fibers has not received attention in Huntington's disease. It is an area of the brain that is late myelinating and is sensitive to both normal aging and neurodegenerative disease effects. Therefore, it may be sensitive to Huntington's disease processes. Methods: Structural MRI data from 25 Pre-symptomatic subjects, 24 Huntington's disease patients and 49 healthy controls was run through a cortical pattern-matching program. The surface corresponding to the white matter directly below the cortical gray matter was then extracted. Individual subject's Diffusion Tensor Imaging (DTI) data was aligned to their structural MRI data. Diffusivity values along the white matter surface were then sampled at each vertex point. DTI measures with high spatial resolution across the superficial white matter surface were then analyzed with the General Linear Model to test for the effects of disease. Results: There was an overall increase in the axial and radial diffusivity across much of the superficial white matter (p < 0.001) in Pre-symptomatic subjects compared to controls. In Huntington's disease patients increased diffusivity covered essentially the whole brain (p < 0.001). Changes are correlated with genotype (CAG repeat number) and disease burden (p < 0.001). Conclusions: This study showed broad abnormalities in superficial white matter even before symptoms are present in Huntington's disease. Since, the superficial white matter has a unique microstructure and function these abnormalities suggest it plays an important role in the disease. PMID:27242403

  18. Major Superficial White Matter Abnormalities in Huntington disease

    Directory of Open Access Journals (Sweden)

    Owen Robert Phillips

    2016-05-01

    Full Text Available BackgroundThe late myelinating superficial white matter at the juncture of the cortical gray and white matter comprising the intracortical myelin and short-range association fibers has not received attention in Huntington’s disease. It is an area of the brain that is late myelinating and is sensitive to both normal aging and neurodegenerative disease effects. Therefore, it may be sensitive to Huntington’s disease processes. MethodsStructural MRI data from 25 Pre-symptomatic subjects, 24 Huntington’s disease patients and 49 healthy controls was run through a cortical pattern-matching program. The surface corresponding to the white matter directly below the cortical gray matter was then extracted. Individual subject’s Diffusion Tensor Imaging (DTI data was aligned to their structural MRI data. Diffusivity values along the white matter surface were then sampled at each vertex point. DTI measures with high spatial resolution across the superficial white matter surface were then analyzed with the General Linear Model to test for the effects of disease. ResultsThere was an overall increase in the axial and radial diffusivity across much of the superficial white matter (p < 0.001 in Pre-symptomatic subjects compared to controls. In Huntington’s disease patients increased diffusivity covered essentially the whole brain (p < 0.001. Changes are correlated with genotype (CAG repeat number and disease burden (p < 0.001.ConclusionsThis study showed broad abnormalities in superficial white matter even before symptoms are present in Huntington’s disease. Since the superficial white matter has a unique microstructure and function these abnormalities suggest it plays an important role in the disease.

  19. Holocene coral patch reef ecology and sedimentary architecture, Northern Belize, Central America

    Energy Technology Data Exchange (ETDEWEB)

    Mazzullo, S.J.; Anderson-Underwood, K.E.; Burke, C.D.; Bischoff, W.D. (Wichita State Univ., KS (United States))

    1992-12-01

    Coral patch reefs are major components of Holocene platform carbonate facies systems in tropical and subtropical areas. The biotic composition, growth and relationship to sea level history, and diagenetic attributes of a representative Holocene patch reef ([open quotes]Elmer Reef[close quotes]) in the Mexico Rocks complex in northern Belize are described and compared to those of Holocene patch reefs in southern Belize. Elmer Reef has accumulated in shallow (2.5 m) water over the last 420 yr, under static sea level conditions. Rate of vertical construction is 0.3-0.5 m/100 yr, comparable to that of patch reefs in southern Belize. A pronounced coral zonation exists across Elmer Reef, with Monastrea annularis dominating on its crest and Acropora cervicornis occurring on its windward and leeward flanks. The dominance of Montastrea on Elmer Reef is unlike that of patch reefs in southern Belize, in which this coral assumes only a subordinate role in reef growth relative to that of Acropora palmata. Elmer Reef locally is extensively biodegraded and marine, fibrous aragonite and some bladed high-magnesium calcite cements occur throughout the reef section, partially occluding corallites and interparticle pores in associated sands. Patch reefs in southern Belize have developed as catch-up and keep-up reefs in a transgressive setting. In contrast, the dominant mode of growth of Elmer Reef, and perhaps other patch reefs in Mexico Rocks, appears to be one of lateral rather than vertical accretion. This style of growth occurs in a static sea level setting where there is only limited accommodation space because of the shallowness of the water, and such reefs are referred to as [open quotes]expansion reefs[close quotes]. 39 refs., 8 figs., 2 tabs.

  20. Fine-Tuning on the Effective Patch Radius Expression of the Circular Microstrip Patch Antennas

    Directory of Open Access Journals (Sweden)

    A. E. Yilmaz

    2010-09-01

    Full Text Available In this study, the effective patch radius expression for the circular microstrip antennas is improved by means of several manipulations. Departing from previously proposed equations in the literature, one of the most accurate equations is picked up, and this equation is fine-tuned by means of Particle Swarm Optimization technique. Throughout the study, impacts of other parameters (such as the definition of the fitness/objective function, the degree-of-freedom in the proposed effective patch radius expression, the number of measured resonant frequency values are observed in a controlled manner. Finally, about 3% additional improvement is achieved over a very accurate formula, which was proposed earlier.

  1. Patch-based vehicle logo detection with patch intensity and weight matrix

    Institute of Scientific and Technical Information of China (English)

    刘海明; 黄樟灿; Ahmed Mahgoub Ahmed Talab

    2015-01-01

    A patch-based method for detecting vehicle logos using prior knowledge is proposed. By representing the coarse region of the logo with the weight matrix of patch intensity and position, the proposed method is robust to bad and complex environmental conditions. The bounding-box of the logo is extracted by a thershloding approach. Experimental results show that 93.58% location accuracy is achieved with 1100 images under various environmental conditions, indicating that the proposed method is effective and suitable for the location of vehicle logo in practical applications.

  2. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice.

    Science.gov (United States)

    Yamago, G; Takata, Y; Furuta, I; Urase, K; Momoi, T; Huh, N

    2001-09-01

    Embryonic induction of hair follicles is a fascinating model of localized morphogenesis from a simple homogeneous epithelial cell sheet. Accumulating evidence indicates that Sonic hedgehog (Shh) signaling plays a central role in hair follicle formation. We quantitated the expression levels of Shh and its receptor genes, Patched (Ptc) and Patched-2 (Ptch2), in two distinct experimental systems in which the development of hair follicles was suppressed. Shh, Ptc, and Ptch2 were induced about six- to tenfold in normal embryonic hair germs in vivo as well as in developing skin tissue maintained in organ culture. This induction was almost completely inhibited both in the developing skin tissue of ICR mice cultured with 30ng/ml epidermal growth factor and in embryos of Tabby mutant mice (a model of hypohidrotic ectodermal dysplasia) at 14.5-15.5 days postcoitus. Expression of Shh, Ptc and Ptch2 was induced in the Tabby embryos at 16.5 days postcoitus, indicating that Shh signaling may be involved in the formation not only of the well-studied guard hair but also of the awl hair. The potential of the two biological systems for studying molecular mechanisms in hair follicle formation, particularly at an early phase including Shh signaling, is discussed.

  3. Contact Dermatitis, Patch Testing, and Allergen Avoidance.

    Science.gov (United States)

    Burkemper, Nicole M

    2015-01-01

    In patients presenting with a complaint of rash, contact dermatitis is often the underlying diagnosis making it an entity with which health care providers should be familiar. Contact dermatitis can be divided into irritant contact dermatitis and allergic contact dermatitis. In a patient suspected of having allergic contact dermatitis, patch testing can be done to identify specific allergens. Education focused on allergen avoidance and safe products is an integral part of treatment for the contact dermatitis patient. Knowledge of the most common allergens is helpful for clinicians to be able to provide this education.

  4. Patch Testing In Soldiers : An Evaluation

    Directory of Open Access Journals (Sweden)

    Walia N. S

    2004-01-01

    Full Text Available Our study concerns contact sensitization in soldiers, the frequency of which is poorly documented. During a six-year period, 128 patients of age range 17-50 years were patch tested with the Indian standard battery of 30 allergens. We obtained a reaction in 23 (18% of our patients. Nickel sulfate, fragrance mix, wool alcohol and parthenium induced most of the positive responses. In addition, an irritant reaction was seen in 16 (12.5% of our patients. Patients of atopic dermatitis and hand/foot dermatoses evoked a high sensitivity response. Adverse effects were seen in 15 patients.

  5. Patch testing with Indian standard series

    Directory of Open Access Journals (Sweden)

    Narendra G

    2002-01-01

    Full Text Available Hundred patients (61 males, 39 females suspected to have allergic contact dermatitis were patch tested with Indian standard series (ISS. Forty four showed one or more positive reactions. The frequent sensitizers observed were nickel sulphate-12 (15%, potassium dichromate-11 (13.75%, cobalt chloride and colophony-7 (8.75% each, fragrance mix and thiuram mix-6 (7.5% each. The ISS differs from the European Standard Series by inclusion of propylene glycol, nitrofurazone, gentamicin, chlorocresol, PEG-400 and ethylenediamine chloride where assesquiterpene lactone mix and primin allergens are excluded.

  6. Compact filtering monopole patch antenna with dual-band rejection.

    Science.gov (United States)

    Kim, Sun-Woong; Choi, Dong-You

    2016-01-01

    In this paper, a compact ultra-wideband patch antenna with dual-band rejection is proposed. The proposed antenna filters 3.3-3.8 GHz WiMAX and 5.15-5.85 GHz WLAN by respectively rejecting these bands through a C-shaped slit and a λg/4 resonator. The λg/4 resonator is positioned as a pair, centered around the microstrip line, and a C-type slit is inserted into an elliptical patch. The impedance bandwidth of the proposed antenna is 2.9-9.3 GHz, which satisfies the bandwidth for ultra-wideband communication systems. Further, the proposed antenna provides dual-band rejection at two bands: 3.2-3.85 and 4.7-6.03 GHz. The radiation pattern of the antenna is omnidirectional, and antenna gain is maintained constantly while showing -8.4 and -1.5 dBi at the two rejected bands, respectively.

  7. Cytokine expression in Peyer's patches following hemorrhage and resuscitation.

    Science.gov (United States)

    Shenkar, R; Chang, Y H; Abraham, E

    1994-01-01

    Intestinal dysfunction commonly occurs following hemorrhage and injury and appears to contribute to the development of multiple organ system failure in this setting. In order to examine possible mechanisms leading to intestinal dysfunction following blood loss, we investigated mRNA levels for cytokines with proinflammatory and immunoregulatory properties (interleukin 1 beta (IL-1 beta), IL-6, IL-10, TNF-alpha, TGF-beta, IFN-gamma) as well as mRNA expression for inducible nitric oxide synthase (NOS) over the 3 days following hemorrhage and resuscitation. Significantly increased levels of mRNA for IL-1 beta, IL-10, and IFN-gamma were found among cells isolated from Peyer's patches 3 days following hemorrhage. Amounts of mRNA for inducible NOS were not significantly altered 24 or 72 h after blood loss. In addition to being increased 72 h following hemorrhage, levels of mRNA for IL-10 also were increased 1 and 4 h posthemorrhage. No alterations in cytokine or NOS expression were found 24 h following blood loss. These results demonstrate that significant increases in proinflammatory and immunoregulatory cytokine mRNA levels among cellular populations in Peyer's patches are present at late posthemorrhage time points. These alterations in cytokine expression may contribute to the morphologic, immunologic, and functional changes in the intestines which are present following blood loss and injury.

  8. Lidocaine patches reduce pain in trauma patients with rib fractures.

    Science.gov (United States)

    Zink, Karen A; Mayberry, John C; Peck, Ellen G; Schreiber, Martin A

    2011-04-01

    Rib fracture pain is notoriously difficult to manage. The lidocaine patch is effective in other pain scenarios with an excellent safety profile. This study assesses the efficacy of lidocaine patches for treating rib fracture pain. A prospectively gathered cohort of patients with rib fracture was retrospectively analyzed for use of lidocaine patches. Patients treated with lidocaine patches were matched to control subjects treated without patches. Subjective pain reports and narcotic use before and after patch placement, or equivalent time points for control subjects, were gathered from the chart. All patients underwent long-term follow-up, including a McGill Pain Questionnaire (MPQ). Twenty-nine patients with lidocaine patches (LP) and 29 matched control subjects (C) were analyzed. During the 24 hours before patch placement, pain scores and narcotic use were similar (LP 5.3, C 4.6, P = 0.19 and LP 51, C 32 mg morphine, P = 0.17). In the 24 hours after patch placement, LP patients had a greater decrease in pain scores (LP 1.2, C 0.0, P = 0.01) with no change in narcotic use (LP -8.4, C 0.5-mg change in morphine, P = 0.25). At 60 days, LP patients had a lower MPQ pain score (LP 7.7, C 12.2, P rib fracture pain. Lidocaine patches resulted in a sustained reduction in pain, outlasting the duration of therapy.

  9. Interpatch movement of the red milkweed beetle, Tetraopes tetraophthalmus: individual responses to patch size and isolation.

    Science.gov (United States)

    Matter, Stephen F

    1996-03-01

    Individual movement patterns and the effects of host plant patch size and isolation on patch occupancy were examined for red milkweed beetles, Tetraopes tetraophthalmus, residing in a heterogeneous landscape. Male beetles were found to move both more often and farther between host plant patches than female beetles, and this difference affected the patterns of patch occupancy observed. Overall, unoccupied milkweed patches were smaller and more isolated than patches occupied by beetles. Patches uninhabited by females tended to be more isolated, but not necessarily smaller, than patches with female beetles, indicating that females may be affected more by patch isolation than patch size. Presence of male beetles on patches showed a stronger response to patch size than to patch isolation. Differences in movement between males and females illustrate the need for demographically based dispersal data. Comparisons of Tetraopes interpatch movement patterns between landscapes composed of patches of different size revealed that landscapes with overall smaller patches may have greater rates of interpatch movement.

  10. Safety, efficacy and patient acceptability of the combined estrogen and progestin transdermal contraceptive patch: a review

    Directory of Open Access Journals (Sweden)

    Alessandra Graziottin

    2008-11-01

    Full Text Available Alessandra GraziottinCenter of Gynecology and Medical Sexology, H San Raffaele Resnati, Via Santa Croce 10/a, 20123 Milano, ItalyAbstract: The worldwide introduction of the first, unique patch for hormonal contraception (ethinyl estradiol/norelgestromin, EE/NGMN patch was widely recognized as a significant event in the development of drug delivery systems. This innovation offers a number of advantages over the oral route, and extensive clinical trials have proved its safety, efficacy, effectiveness, and tolerability. The weekly administration and ease of use/simplicity of the EE/NGMN patch contribute to its acceptability, and help to resolve the two main problems of non-adherence, namely early discontinuation and inconsistent use. The patch offers additional benefits to adolescents (improvement of dysmenorrhea and acne, adults (improvement in emotional and physical well-being, premenstrual syndrome, and menstrual irregularities, and perimenopausal women (correction of hormonal imbalance, modulation of premenopausal symptoms, thus providing high satisfaction rates (in nearly 90% of users. Since its introduction, the transdermal contraceptive patch has proved to be a useful choice for women who seek a convenient formulation which is easy to use, with additional, non-contraceptive tailored benefits for all the ages.Keywords: transdermal, hormonal contraceptive, patient satisfaction, patient adherence

  11. Patch Antenna based on a Photovoltaic Cell with a Dual resonance Frequency

    Directory of Open Access Journals (Sweden)

    C. Baccouch

    2016-11-01

    Full Text Available The present work was to use photovoltaic solar cells in patch antenna structures. The radiating patch element of a patch antenna was replaced by a solar cell. Direct Current (DC generation remained the original feature of the solar cell, but additionally   it was now able to receive and transmit electromagnetic waves. Here, we used a new patch antenna structure based on a photovoltaic solar cell. It was then used to collect photo-generated current as well as Radio Frequency (RF transmission. A mathematical model which would serve the minimization of power losses of the cell and therefore the improvement in the conversion efficiency was studied. A simulation allowed analysing the performance of the antenna, with a silicon material, and testing its parameters such as the reflection coefficient (S11, gain, directivity and radiated power. The performance analysis of the solar cell patch antenna was conducted using Advanced Design System (ADS software. Simulation results for this antenna showed a dual resonance frequency of 5.77 GHz and of 6.18 GHz with an effective return loss of -38.22dB and a gain of 1.59dBi.

  12. Contextual convolutional neural networks for lung nodule classification using Gaussian-weighted average image patches

    Science.gov (United States)

    Lee, Haeil; Lee, Hansang; Park, Minseok; Kim, Junmo

    2017-03-01

    Lung cancer is the most common cause of cancer-related death. To diagnose lung cancers in early stages, numerous studies and approaches have been developed for cancer screening with computed tomography (CT) imaging. In recent years, convolutional neural networks (CNN) have become one of the most common and reliable techniques in computer aided detection (CADe) and diagnosis (CADx) by achieving state-of-the-art-level performances for various tasks. In this study, we propose a CNN classification system for false positive reduction of initially detected lung nodule candidates. First, image patches of lung nodule candidates are extracted from CT scans to train a CNN classifier. To reflect the volumetric contextual information of lung nodules to 2D image patch, we propose a weighted average image patch (WAIP) generation by averaging multiple slice images of lung nodule candidates. Moreover, to emphasize central slices of lung nodules, slice images are locally weighted according to Gaussian distribution and averaged to generate the 2D WAIP. With these extracted patches, 2D CNN is trained to achieve the classification of WAIPs of lung nodule candidates into positive and negative labels. We used LUNA 2016 public challenge database to validate the performance of our approach for false positive reduction in lung CT nodule classification. Experiments show our approach improves the classification accuracy of lung nodules compared to the baseline 2D CNN with patches from single slice image.

  13. Vibration control of a cylindrical shell with concurrent active piezoelectric patches and passive cardboard liner

    Science.gov (United States)

    Plattenburg, Joseph; Dreyer, Jason T.; Singh, Rajendra

    2017-07-01

    This article extends a recent publication [MSSP (2016), 176-196] by developing a Rayleigh-Ritz model of a thin cylindrical shell to predict its response subject to concurrent active and passive damping treatments. These take the form of piezoelectric patches and a distributed cardboard liner, since the effects of such combined treatments are yet to be investigated. Furthermore, prior literature typically considers only the ;bimorph; active patch configuration (with patches on the inner and outer shell surfaces), which is not feasible with an interior passive liner treatment. Therefore, a novel configuration-termed as ;unimorph;-is proposed and included in the model. Experiments are performed on a shell with active patches (under harmonic excitation from 200 to 2000 Hz) in both the bimorph and unimorph configurations to provide evidence for the analytical model predictions. The proposed model is then employed to assess competing control system designs by examining local vs. global control schemes as well as considering several alternate active patch locations, both with and without the passive damping. Non-dimensional performance metrics are devised to facilitate comparisons of vibration attenuation among different designs. Finally, insertion loss values are measured under single-frequency excitation to evaluate several vibration control designs, and to compare the effects of alternate damping treatments.

  14. A periodic freshwater patch detachment process from the Block Island Sound estuarine plume

    Science.gov (United States)

    Liu, Qianqian; Rothstein, Lewis M.; Luo, Yiyong

    2017-01-01

    Previous observations suggest periodic freshwater patches separating from the Block Island Sound (BIS) estuarine plume. In this study, the dynamics of the separation process is investigated through a series of numerical experiments using the Regional Ocean Modeling System (ROMS). In addition, we explore the seasonal variability of the freshwater patches and their response to river discharge and ambient current. The model results indicate that episodic freshwater patches are triggered by small changes in tidal currents over the spring-neap tidal cycle. The spring-neap variation in tidal currents causes significant, monthly fluctuations in turbulent mixing and vertical stratification in BIS, modulating the freshwater discharge thereby generating episodic freshwater patches that move both downstream along the southern shore of Long Island and toward Rhode Island Sound (RIS). The realistically configured model shows that the freshwater patches experience strong seasonal variability. They are largest in spring when the river discharge peaks, and smallest in summer due to the weak river discharge and a robust upstream ambient current from RIS. According to the analysis of the freshwater transport out of BIS, we conclude that such detachment occurs at tidal mixing fronts.

  15. Patch forest: a hybrid framework of random forest and patch-based segmentation

    Science.gov (United States)

    Xie, Zhongliu; Gillies, Duncan

    2016-03-01

    The development of an accurate, robust and fast segmentation algorithm has long been a research focus in medical computer vision. State-of-the-art practices often involve non-rigidly registering a target image with a set of training atlases for label propagation over the target space to perform segmentation, a.k.a. multi-atlas label propagation (MALP). In recent years, the patch-based segmentation (PBS) framework has gained wide attention due to its advantage of relaxing the strict voxel-to-voxel correspondence to a series of pair-wise patch comparisons for contextual pattern matching. Despite a high accuracy reported in many scenarios, computational efficiency has consistently been a major obstacle for both approaches. Inspired by recent work on random forest, in this paper we propose a patch forest approach, which by equipping the conventional PBS with a fast patch search engine, is able to boost segmentation speed significantly while retaining an equal level of accuracy. In addition, a fast forest training mechanism is also proposed, with the use of a dynamic grid framework to efficiently approximate data compactness computation and a 3D integral image technique for fast box feature retrieval.

  16. Patch size has no effect on insect visitation rate per unit area in garden-scale flower patches

    Science.gov (United States)

    Garbuzov, Mihail; Madsen, Andy; Ratnieks, Francis L. W.

    2015-01-01

    Previous studies investigating the effect of flower patch size on insect flower visitation rate have compared relatively large patches (10-1000s m2) and have generally found a negative relationship per unit area or per flower. Here, we investigate the effects of patch size on insect visitation in patches of smaller area (range c. 0.1-3.1 m2), which are of particular relevance to ornamental flower beds in parks and gardens. We studied two common garden plant species in full bloom with 6 patch sizes each: borage (Borago officinalis) and lavender (Lavandula × intermedia 'Grosso'). We quantified flower visitation by insects by making repeated counts of the insects foraging at each patch. On borage, all insects were honey bees (Apis mellifera, n = 5506 counts). On lavender, insects (n = 737 counts) were bumble bees (Bombus spp., 76.9%), flies (Diptera, 22.4%), and butterflies (Lepidoptera, 0.7%). On both plant species we found positive linear effects of patch size on insect numbers. However, there was no effect of patch size on the number of insects per unit area or per flower and, on lavender, for all insects combined or only bumble bees. The results show that it is possible to make unbiased comparisons of the attractiveness of plant species or varieties to flower-visiting insects using patches of different size within the small scale range studied and make possible projects aimed at comparing ornamental plant varieties using existing garden flower patches of variable area.

  17. Field Deployable Fiber Bragg Grating Strain Patch for Long-Term Stable Health Monitoring Applications

    Directory of Open Access Journals (Sweden)

    Gerhard Kalinka

    2013-01-01

    Full Text Available A fiber Bragg grating (FBG strain patch specially adapted for long-term and high-strain applications has been developed and characterized. The design concept for the patch is based on a glass-fiber reinforced plastic (gfrp carrier material. The developed concept for the FBG integration into the carrier material was derived from reliable integration procedure of FBG sensors into composite structures. The patches’ temperature sensitivity, strain gauge factor, fiber–matrix interface adhesion and fatigue behavior were characterized. As a result, FBG strain patches with linear temperature and strain behavior, as well as excellent fatigue resistance, were developed and can be used as part of a monitoring system for advanced composite materials in aerospace structures or wind turbine power plants.

  18. Implementing optical fibres for the structural health monitoring of composite patch repaired structures

    DEFF Research Database (Denmark)

    Karatzas, Vasileios; Kotsidis, Elias A.; Tsouvalis, Nicholas G.

    2017-01-01

    are reflected to the recorded strain measurements, finite element models have been generated. Results indicate that composite patch repairing drastically increased the load bearing capacity of the plates and that optical fibres constitute an appealing health monitoring system for such applications, being able......Structural health monitoring is increasingly being implemented to improve the level of safety of structures and to reduce inspection and repair costs by allowing for correct planning of these actions, if needed. Composite patch repairing presents an appealing alternative to traditional repair...... methods as it enables the reduction of closedown time and the mitigation of complications associated with traditional repair methods. As reinforcement with the use of composite patches is predominantly performed at defected structures, the urge to monitor the performance of the repair becomes even greater...

  19. Trigeminal postherpetic neuralgia responsive to treatment with capsaicin 8 % topical patch: a case report.

    Science.gov (United States)

    Sayanlar, Jennifer; Guleyupoglu, Nilufer; Portenoy, Russell; Ashina, Sait

    2012-10-01

    Postherpetic neuralgia has been variably defined but is generally understood to be pain that persists for longer than a few months after an attack of herpes zoster. Pain persists for years in approximately 10 % of those afflicted with acute herpes zoster. The likelihood of postherpetic neuralgia increases with older age, severity of the zoster, trigeminal location, and other factors. Postherpetic neuralgia is a neuropathic pain and treatment usually involves sequential trials of topical and systemic drugs; a variety of other therapies may be considered in refractory cases. A new topical capsaicin 8 % patch has been approved for this indication based on the positive studies in patients with non-trigeminal postherpetic neuralgia. Experience with the use of the capsaicin 8 % patch for trigeminal distribution neuralgia is lacking. We report a case of trigeminal postherpetic neuralgia which was safely and effectively treated with capsaicin 8 % patch.

  20. Novel On-wafer Radiation Pattern Measurement Technique for MEMS Actuator Based Reconfigurable Patch Antennas

    Science.gov (United States)

    Simons, Rainee N.

    2002-01-01

    The paper presents a novel on-wafer, antenna far field pattern measurement technique for microelectromechanical systems (MEMS) based reconfigurable patch antennas. The measurement technique significantly reduces the time and the cost associated with the characterization of printed antennas, fabricated on a semiconductor wafer or dielectric substrate. To measure the radiation patterns, the RF probe station is modified to accommodate an open-ended rectangular waveguide as the rotating linearly polarized sampling antenna. The open-ended waveguide is attached through a coaxial rotary joint to a Plexiglas(Trademark) arm and is driven along an arc by a stepper motor. Thus, the spinning open-ended waveguide can sample the relative field intensity of the patch as a function of the angle from bore sight. The experimental results include the measured linearly polarized and circularly polarized radiation patterns for MEMS-based frequency reconfigurable rectangular and polarization reconfigurable nearly square patch antennas, respectively.

  1. Real-time UV imaging of nicotin release from transdermal patch

    DEFF Research Database (Denmark)

    Østergaard, Jesper; Meng-Lund, Emil; Larsen, Susan Weng

    2010-01-01

    PURPOSE: This study was conducted to characterize UV imaging as a platform for performing in vitro release studies using Nicorette® nicotine patches as a model drug delivery system. METHODS: The rate of nicotine release from 2 mm diameter patch samples (Nicorette®) into 0.067 M phosphate buffer, p...... of nicotine. Release profiles obtained from UV imaging were in qualitative agreement with results from the paddle-over-disk release method. CONCLUSION: Visualization as well as quantification of nicotine concentration gradients was achieved by UV imaging in real time. UV imaging has the potential to become...

  2. Characteristic-Based Time Domain Method for Cylindrically Conformal Microstrip Patch Antennas

    Institute of Scientific and Technical Information of China (English)

    XU Xiao-wen; XIN Li

    2005-01-01

    The characteristics of a cylindrical conformal microstrip patch antenna are analyzed by using the characteristic-based time domain (CBTD) method. A governing equation in the cylindrical coordinate system is formulated directly to facilitate the analysis of cylindrically conformal microstrip patch antennas. The algorithm has second-order accuracy both in time and space domain and has the potential to eliminate the spurious wave reflection from the numerical boundaries of the computational domain. Numerical results demonstrate the important merits and accuracy of the proposed technique in computational electromagnetics.

  3. A new photonic bandgap cover for a patch antenna with a photonic bandgap substrate

    Institute of Scientific and Technical Information of China (English)

    林青春; 朱方明; 何赛灵

    2004-01-01

    A new photonic bandgap (PBG) cover for a patch antenna with a photonic bandgap substrate is introduced. The plane wave expansion method and the FDTD method were used to calculate such an antenna system. Numerical results for the input return loss, radiation pattern, surface wave, and the directivity of the antennas are presented. A comparison between the conventional patch antenna and the new PBG antenna is given. It is shown that the new PBG cover is very efficient for improving the radiation directivity. The physical reasons for the improvement are also given.

  4. A Composite Heterostructure Mesh-shaped Patch Antenna Based on Left Handed Material

    Directory of Open Access Journals (Sweden)

    Ji jun Wang

    2014-01-01

    Full Text Available In this paper, a composite heterostructure mesh-shaped patch antenna based on left handed material (LHM is presented. The method of finite difference time domain (FDTD is used. The results show that electromagnetic wave resonance occurs near 4.52 GHz, where the equivalent permittivity and permeability of composite material are both negative. The composite antenna’s gain improves 9.047 dB, its return loss reduces 20.26 dB compared to the conventional antenna’s ones. The results indicate that this composite patch antenna system can reduce return loss of the antenna and increase the gain obviously.

  5. A combined chemo-mechanical approach for aesthetic management of superficial enamel defects

    NARCIS (Netherlands)

    Ardu, S.; Benbachir, N.; Stavridakis, M.; Dietschi, D.L.; Krejci, I.; Feilzer, A.J.

    2009-01-01

    Objective The aim of this article is to describe an easy technique for managing small superficial defects in light to medium fluorosis. Method and materials The proposed technique is based on a selective abrasion of the superficial enamel and a recreation of the superficial macro and micro morpholog

  6. A combined chemo-mechanical approach for aesthetic management of superficial enamel defects

    NARCIS (Netherlands)

    Ardu, S.; Benbachir, N.; Stavridakis, M.; Dietschi, D.L.; Krejci, I.; Feilzer, A.J.

    2009-01-01

    Objective The aim of this article is to describe an easy technique for managing small superficial defects in light to medium fluorosis. Method and materials The proposed technique is based on a selective abrasion of the superficial enamel and a recreation of the superficial macro and micro morpholog

  7. Rugosidad y textura de superficies: experimentos y simulaciones

    Directory of Open Access Journals (Sweden)

    Watson L. Vargas

    2006-01-01

    Full Text Available En este trabajo se aplican algunos elementos de la geometría fractal al estudio y caracterización de la rugosidad superficial. Los materiales bajo estudio consisten en agregados naturales, de amplia aplicación en la industria de la construcción. Se aplican tanto técnicas experimentales basadas en análisis de imágenes como modelos teóricos. En particular se explora el potencial de la lacunaridad –un método de análisis derivado de la geometría fractal, para describir patrones y dispersión espacial. Los resultados ilustran su aplicación en la caracterización de rugosidad superficial. Se discuten igualmente, limitaciones y ventajas de esta aproximación.

  8. Effects of superficial gas velocity on process dynamics in bioreactors

    Science.gov (United States)

    Devi, T. T.; Kumar, B.

    2014-06-01

    Present work analyzes the flow hydrodynamics and mass transfer mechanisms in double Rushton and CD-6 impeller on wide range (0.0075-0.25 m/s) of superficial gas velocity ( v g) in a gas-liquid phase bioreactor by employing computational fluid dynamics (CFD) technique. The volume averaged velocity magnitude and dissipation rate are found higher with increasing superficial gas velocity. Higher relative power draw ( P g/ P 0) is predicted in CD-6 than the Rushton impeller but no significant difference in volume averaged mass transfer coefficient ( k L a) observed between these two types of impeller. The ratio of power draw with mass transfer coefficient has been found higher in CD-6 impeller (25-50 %) than the Rushton impeller.

  9. Variation in the Branching Pattern of the Superficial Palmar Arch

    Directory of Open Access Journals (Sweden)

    Sumalatha S

    2016-05-01

    Full Text Available In this article we describe a rare variation in the superficial palmar arch (SPA encountered during routine cadaveric dissection. SPA was formed by the superficial branches of ulnar and radial arteries which provided a proper digital branch to the ulnar side of the little finger and three common palmar digital branches to the medial four digits. Additionally a first common digital artery was seen to emerge from the radial side of SPA which further divided into the arteria princeps pollicis and arteria radialis indicis. We also found a small communicating branch between the arteria princeps pollicis and the radial artery in the anatomical snuff box. Such arterial variations in the palm due to alteration in the developmental sequence remains a crucial issue in the reconstructive hand surgeries, especially while dealing with the innovative microsurgical procedures, where these varied patterns act as pivotal points around which successful results of various advanced surgical procedures revolve.

  10. Movimiento superficial del glaciar rocoso de las Argualas

    Directory of Open Access Journals (Sweden)

    Sanjosé, J. J.

    1995-12-01

    Full Text Available At present the Argualas rock glacier is active and it flows to a surface axial mean velocity of 22,3 cm/year. The flow velocities have been determinated by surveying techniques made between 1991 and 1994. This technic complements the geomorphological observations and deepens in the knov/ledge of the glacier surface dynamics.

    El glaciar rocoso de las Argualas es activo en la actualidad y fluye a una velocidad media axial en superficie de 22.3 cm/año. El flujo se ha determinado median te las técnicas de auscultación topográfica realizadas entre los años 1991 y 1994. Esta técnica ha permitido complementar el análisis geomorfológico, profundizado en el estudio de la dinámica superficial del glaciar.

  11. Endoscopic removal or ablation of oesophageal and gastric superficial tumours.

    Science.gov (United States)

    Deprez, P H; Aouattah, T; Piessevaux, H

    2006-01-01

    Endoscopic mucosal resection was developed in Eastern countries as a curative treatment for superficial carcinomas in the stomach and oesophagus. Experience in Western countries is more recent and limited due to less frequent diagnosis of early gastric cancers compared to the Japanese and Korean populations and to more frequent use of ablation techniques such as argon plasma coagulation and photodynamic therapy in pre-neoplastic lesions and superficial tumours. This review summarizes the respective indications, advantages, disadvantages, limitations and complications of the different ablative and resection techniques in the upper gastrointestinal tract. Several methods are described such as electrocoagulation, argon plasma coagulation, photodynamic therapy, lift and cut resection, cap assisted aspiration and band ligation mucosectomy, and endoscopic submucosal dissection. Local results in more than 170 patients managed with endoscopic resection of oesophageal high grade dysplasia or squamous cell carcinoma and gastric or Barrett's epithelium high grade dysplasia or adenocarcinoma furthermore demonstrate the safety and effectiveness of endoscopic resection practiced in experienced centres.

  12. Causative agents of superficial mycoses in Istanbul, Turkey: retrospective study.

    Science.gov (United States)

    Koksal, Fatma; Er, Emine; Samasti, Mustafa

    2009-09-01

    The aim of the present study was to determine the percentage of agents, which can give rise to superficial fungal infections in Istanbul, Turkey. Between 2000 and 2007, the clinical samples collected from 8,200 patients attending the outpatient Dermatology Clinic at Mihrimahsultan Medical Center were examined by direct microscopy and culture. Pathogen fungi were detected in 5,722 of the patients. Of the isolates were 4,218 (74%) dermatophytes, 1,196 (21%) Candida sp., 170 (3%) Malassezia furfur, and 138 (2%) Trichosporon sp. Among the dermatophytes, Trichophyton sp. was the most common isolate followed by Epidermophyton floccosum (243) and Microsporum sp. Among the Candida species, C. albicans (549) was also frequently found. Onychomycosis was the most prevalent type of infection, followed by tinea pedis, tinea cruris, tinea corporis, and tinea capitis. In conclusion, our study showed that the most common isolated agents from superficial infections were T. rubrum being Candida sp. the second most prevalent.

  13. The hedgehog receptor patched is involved in cholesterol transport.

    Directory of Open Access Journals (Sweden)

    Michel Bidet

    Full Text Available BACKGROUND: Sonic hedgehog (Shh signaling plays a crucial role in growth and patterning during embryonic development, and also in stem cell maintenance and tissue regeneration in adults. Aberrant Shh pathway activation is involved in the development of many tumors, and one of the most affected Shh signaling steps found in these tumors is the regulation of the signaling receptor Smoothened by the Shh receptor Patched. In the present work, we investigated Patched activity and the mechanism by which Patched inhibits Smoothened. METHODOLOGY/PRINCIPAL FINDINGS: Using the well-known Shh-responding cell line of mouse fibroblasts NIH 3T3, we first observed that enhancement of the intracellular cholesterol concentration induces Smoothened enrichment in the plasma membrane, which is a crucial step for the signaling activation. We found that binding of Shh protein to its receptor Patched, which involves Patched internalization, increases the intracellular concentration of cholesterol and decreases the efflux of a fluorescent cholesterol derivative (BODIPY-cholesterol from these cells. Treatment of fibroblasts with cyclopamine, an antagonist of Shh signaling, inhibits Patched expression and reduces BODIPY-cholesterol efflux, while treatment with the Shh pathway agonist SAG enhances Patched protein expression and BODIPY-cholesterol efflux. We also show that over-expression of human Patched in the yeast S. cerevisiae results in a significant boost of BODIPY-cholesterol efflux. Furthermore, we demonstrate that purified Patched binds to cholesterol, and that the interaction of Shh with Patched inhibits the binding of Patched to cholesterol. CONCLUSION/SIGNIFICANCE: Our results suggest that Patched may contribute to cholesterol efflux from cells, and to modulation of the intracellular cholesterol concentration. This activity is likely responsible for the inhibition of the enrichment of Smoothened in the plasma membrane, which is an important step in Shh pathway

  14. Dendritic Actin Filament Nucleation Causes Traveling Waves and Patches

    CERN Document Server

    Carlsson, Anders E

    2010-01-01

    The polymerization of actin via branching at a cell membrane containing nucleation-promoting factors is simulated using a stochastic-growth methodology. The polymerized-actin distribution displays three types of behavior: a) traveling waves, b) moving patches, and c) random fluctuations. Increasing actin concentration causes a transition from patches to waves. The waves and patches move by a treadmilling mechanism which does not require myosin II. The effects of downregulation of key proteins on actin wave behavior are evaluated.

  15. Physical Properties of Gum Karaya-Starch-Essential Oil Patches

    OpenAIRE

    2010-01-01

    Essential oils are used in foods, cosmetics, and pharmaceuticals. Despite the recent marketing of novel essential-oil-containing patches, there is no information on their production, constituents, or physical properties. The objectives of this study were to produce essential-oil patches and characterize their physical properties. The essential oil of Lavandula angustifolia (lavender) was included at concentrations of 2.5% to 10% in patches manufactured from the exudate gum karaya, propylene g...

  16. Fast Simulation of Mechanical Heterogeneity in the Electrically Asynchronous Heart Using the MultiPatch Module.

    Directory of Open Access Journals (Sweden)

    John Walmsley

    2015-07-01

    Full Text Available Cardiac electrical asynchrony occurs as a result of cardiac pacing or conduction disorders such as left bundle-branch block (LBBB. Electrically asynchronous activation causes myocardial contraction heterogeneity that can be detrimental for cardiac function. Computational models provide a tool for understanding pathological consequences of dyssynchronous contraction. Simulations of mechanical dyssynchrony within the heart are typically performed using the finite element method, whose computational intensity may present an obstacle to clinical deployment of patient-specific models. We present an alternative based on the CircAdapt lumped-parameter model of the heart and circulatory system, called the MultiPatch module. Cardiac walls are subdivided into an arbitrary number of patches of homogeneous tissue. Tissue properties and activation time can differ between patches. All patches within a wall share a common wall tension and curvature. Consequently, spatial location within the wall is not required to calculate deformation in a patch. We test the hypothesis that activation time is more important than tissue location for determining mechanical deformation in asynchronous hearts. We perform simulations representing an experimental study of myocardial deformation induced by ventricular pacing, and a patient with LBBB and heart failure using endocardial recordings of electrical activation, wall volumes, and end-diastolic volumes. Direct comparison between simulated and experimental strain patterns shows both qualitative and quantitative agreement between model fibre strain and experimental circumferential strain in terms of shortening and rebound stretch during ejection. Local myofibre strain in the patient simulation shows qualitative agreement with circumferential strain patterns observed in the patient using tagged MRI. We conclude that the MultiPatch module produces realistic regional deformation patterns in the asynchronous heart and that

  17. Measurement of the angle of superficial tension by images

    Science.gov (United States)

    Yanez M., Javier; Alonso R., Sergio

    2006-02-01

    When a liquid is deposited on a surface, this one form a certain angle with respect to the surface, where depending on its value, it will conclude that so hard it is his adhesion with the surface. By means of the analysis of images we looked for to measure this angle of superficial tension. In order to make this measurement, we propose a technique by means of projective transformations and one method of regression to estimation parameters to conic fitting.

  18. Cervical Spinal Meningeal Melanocytoma Presenting as Intracranial Superficial Siderosis

    Directory of Open Access Journals (Sweden)

    Savitha Srirama Jayamma

    2015-01-01

    Full Text Available Meningeal melanocytoma is a rare pigmented tumor of the leptomeningeal melanocytes. This rare entity results in diagnostic difficulty in imaging unless clinical and histopathology correlation is performed. In this case report, we describe a case of meningeal melanocytoma of the cervical region presenting with superficial siderosis. Extensive neuroradiological examination is necessary to locate the source of the bleeding in such patients. Usually, the patient will be cured by the complete surgical excision of the lesion.

  19. Superficial urinary bladder tumors treatment results: A 10-year experience

    Directory of Open Access Journals (Sweden)

    Stanković Jablan

    2007-01-01

    Full Text Available Background/Aim. The most common urinary bladder tumors are superficial tumors. Due to their tension to relapse and progress towards deeper layers after surgical therapy, an adequate therapy significantly contributed to the improvement of the results of urinary bladder tumors treatment. Staging and gradus of the tumor, presence of the carcinoma in situ (CIS or relapses significantly influenced the choice of the therapy. The aim of this study was to ascertain the effectiveness of the intravesicelly applied BCG (Bacille Colmette - Guerin vaccine or chemiotherapy in the prevention of the relapses and further progression of superficial urinary bladder tumors. Methods. All of the diagnosed superficial tumors of bladder were removed by transurethral resection (TUR. After receiving the patohistological finding they were subjected to adjuvant therapy, immune BCG vaccine or chemiotherapy (epirubicin, doxorubicin, mitomycin-C. The third group did not accept adjuvant therapy, but had regularly scheduled cystoscopic controls. The appearance of relapses, progression of stage and grades of the tumor, as well as possible unwanted effects of adjuvant therapy were registered. Results. The applied immunotherapy (BCG influenced decreased tumor relapses (7% and statistically important difference between patients who had taken adjuvant chemotherapy (relapses 18.4% and those without this therapy was acknowledged. Grades of tumor did not show statistically significant difference on tumor relapse. A significantly longer period of time in the appearance of tumor relapse after BCG (29.33 months, had significant importance comparing to chemio (9.44 months or non-taken adjuvant therapy (9.84 months. Very small number of unwanted effects suggested an obligatory undertaking adjuvant therapy after TUR of superficial tumors. Conclusion. A significant decrease of relapses as well as avoidance of further progression of urinary bladder tumors, has introduced adjuvant therapy in

  20. Transient superficial peroneal nerve palsy after anterior cruciate ligament reconstruction

    OpenAIRE

    Majed Alrowaili

    2016-01-01

    A 19-year-old male subject was diagnosed with medial meniscal, lateral meniscal and anterior cruciate ligament (ACL) tear. The symptoms did not subside after 4 months of physical therapy, and he underwent arthroscopic partial medial and lateral meniscectomy and ACL reconstruction. Immediately after the patient woke up from general anesthesia, he started experience loss of sensation in the area of superficial peroneal nerve with inverted dorsiflexion of foot and ankle. Instantly, the bandage a...

  1. Hierarchical spatial segregation of two Mediterranean vole species: the role of patch-network structure and matrix composition.

    Science.gov (United States)

    Pita, Ricardo; Lambin, Xavier; Mira, António; Beja, Pedro

    2016-09-01

    According to ecological theory, the coexistence of competitors in patchy environments may be facilitated by hierarchical spatial segregation along axes of environmental variation, but empirical evidence is limited. Cabrera and water voles show a metapopulation-like structure in Mediterranean farmland, where they are known to segregate along space, habitat, and time axes within habitat patches. Here, we assess whether segregation also occurs among and within landscapes, and how this is influenced by patch-network and matrix composition. We surveyed 75 landscapes, each covering 78 ha, where we mapped all habitat patches potentially suitable for Cabrera and water voles, and the area effectively occupied by each species (extent of occupancy). The relatively large water vole tended to be the sole occupant of landscapes with high habitat amount but relatively low patch density (i.e., with a few large patches), and with a predominantly agricultural matrix, whereas landscapes with high patch density (i.e., many small patches) and low agricultural cover, tended to be occupied exclusively by the small Cabrera vole. The two species tended to co-occur in landscapes with intermediate patch-network and matrix characteristics, though their extents of occurrence were negatively correlated after controlling for environmental effects. In combination with our previous studies on the Cabrera-water vole system, these findings illustrated empirically the occurrence of hierarchical spatial segregation, ranging from within-patches to among-landscapes. Overall, our study suggests that recognizing the hierarchical nature of spatial segregation patterns and their major environmental drivers should enhance our understanding of species coexistence in patchy environments.

  2. Cost benefit of patch testing with textile finish resins

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Hamann, K

    1982-01-01

    Eleven years experience of textile finish resin patch testing of suspected textile dermatitis patients revealed 15 cases of allergic textile dermatitis among 428 patients tested. Ten of the 15 patients had a relevant positive patch test to one or more of a limited series of textile finishes; 1...... was negative and 4 were not tested with textile finishes. All 15 patients were formaldehyde sensitive. No unexpected, relevant, positive textile finish resin patch test was found. In this study a negative patch test to formaldehyde virtually excluded allergic contact dermatitis from textile finishes....

  3. Histological distinction between early allergic and irritant patch test reactions

    DEFF Research Database (Denmark)

    Vestergaard, L; Clemmensen, Ole; Sørensen, Flemming Brandt

    1999-01-01

    differentiate between early allergic and irritant patch test reactions. 8 patients with known contact allergy to either colophony or quarternium-15 participated in the study. In each patient, allergic and irritant patch tests reactions were elicited, and 4-mm punch biopsies were taken after 6 8 h from...... clinically equipotent reactions. Paired sets of slides were assessed blindly by 2 pathologists. 1 patient showing a pityrosporum folliculitis was excluded from the study. All biopsies from allergic patch tests were characterized by follicular spongiosis, while biopsies from irritant patch tests showed...... the diagnostic significance of the histological classification of allergic and irritant cutaneous reactions in punch biopsies....

  4. Facile route to morphologically tailored silver patches on colloidal particles.

    Science.gov (United States)

    Klupp Taylor, Robin N; Bao, Huixin; Tian, Chenting; Vasylyev, Serhiy; Peukert, Wolfgang

    2010-08-17

    Here we demonstrate, for the first time, the heterogeneous nucleation and growth of silver patches on submicrometer silica spheres. While patches can be grown directly onto native silica particles, it is shown that a higher patch yield can be obtained by first treating the silica with a mixture of an alkanolamine and silver nitrate. Variation of the pretreatment and subsequent coating reactions allowed the patch yield, number, size, thickness, and shape to be adjusted. The patchy particles were shown to possess plasmon modes extending from the visible into the near-IR region, making these structures highly interesting for both their asymmetric morphological and functional properties.

  5. Characterization of a patch-clamp microchannel array towards neuronal networks analysis

    DEFF Research Database (Denmark)

    Alberti, Massimo; Snakenborg, Detlef; Lopacinska, Joanna M.

    2010-01-01

    for simultaneous patch clamping of cultured cells or neurons in the same network. A disposable silicon/silicon dioxide (Si/SiO2) chip with a microhole array was integrated in a microfluidic system for cell handling, perfusion and electrical recording. Fluidic characterization showed that our PC mu CA can work...

  6. EX1201: Ship Shakedown and Patch Tests on NOAA Ship Okeanos Explorer between 20100214 and 20120223

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — EX1201 is the 2012 shakedown mission of NOAA ship Okeanos Explorer (EX) and will perform system patch tests of the vessel’s Kongsberg EM302 multibeam sonar....

  7. Probe-Fed Stacked Microstrip Patch Antenna for High-Resolution Polarimetric C-Band SAR

    DEFF Research Database (Denmark)

    Granholm, Johan; Skou, Niels

    2000-01-01

    The paper describes a C-band, dual-linear polarization wideband antenna for use in the next-generation of the Danish high-resolution, airborne polarimetric synthetic aperture radar (SAR) system, EMISAR. The design and performance of a probe-fed, stacked microstrip patch element, operating from 4...

  8. Hydroxychloroquine-induced acute generalized exanthematous pustulosis with positive patch-testing

    Directory of Open Access Journals (Sweden)

    Ons Charfi

    2015-01-01

    Full Text Available Acute generalized exanthematous pustulosis (AGEP is a severe cutaneous adverse reaction, mostly induced by drugs. Hydroxychloroquine have been rarely reported in literature as a causative drug of this reaction. We report a case of AGEP induced by hydroxychloroquine with systemic involvement and confirmed by positive patch testing.

  9. Transdermal administration of radiolabelled [14C]rotigotine by a patch formulation: A mass balance trial

    NARCIS (Netherlands)

    Cawello, W.; Wolff, H.M.; Meuling, W.J.A.; Horstmann, R.; Braun, M.

    2007-01-01

    Background and objective: The dopamine agonist rotigotine has been formulated in a silicone-based transdermal system for once-daily administration. The objective of the present study was to characterise the mass balance of rotigotine in humans after administration of a single transdermal patch conta

  10. Differences in excitability between median and superficial radial sensory axons.

    Science.gov (United States)

    Fujimaki, Yumi; Kanai, Kazuaki; Misawa, Sonoko; Shibuya, Kazumoto; Isose, Sagiri; Nasu, Saiko; Sekiguchi, Yukari; Ohmori, Shigeki; Noto, Yu-ichi; Kugio, Yumiko; Shimizu, Toshio; Matsubara, Shiro; Lin, Cindy S Y; Kuwabara, Satoshi

    2012-07-01

    The aim of this study was to investigate differences in excitability properties of human median and superficial radial sensory axons (e.g., axons innervating the glabrous and hairy skin in the hand). Previous studies have shown that excitability properties differ between motor and sensory axons, and even among sensory axons between median and sural sensory axons. In 21 healthy subjects, threshold tracking was used to examine excitability indices such as strength-duration time constant, threshold electrotonus, supernormality, and threshold change at the 0.2 ms inter-stimulus interval in latent addition. In addition, threshold changes induced by ischemia for 10 min were compared between median and superficial radial sensory axons. Compared with radial sensory axons, median axons showed shorter strength-duration time constant, greater threshold changes in threshold electrotonus (fanning-out), greater supernormality, and smaller threshold changes in latent addition. Threshold changes in both during and after ischemia were greater for median axons. These findings suggest that membrane potential in human median sensory axons is more negative than in superficial radial axons, possibly due to greater activity of electrogenic Na(+)/K(+) pump. These results may reflect adaptation to impulses load carried by median axons that would be far greater with a higher frequency. Biophysical properties are not identical in different human sensory axons, and therefore their responses to disease may differ. Copyright © 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  11. Glans-preserving surgery for superficial penile cancer.

    Science.gov (United States)

    Li, Pengchao; Song, Ninghong; Yin, Changjun; Zhang, Wei; Li, Jie; Hua, Lixin; Wang, Zengjun; Cheng, Gong

    2012-01-01

    In this study, we investigated the safety and feasibility of glans-preserving surgery for superficial penile squamous cell carcinoma. Young patients with penile primary tumors exhibiting favorable histologic features were best suited for organ-sparing procedures, enabling them to avoid sexual disturbances. The study included 12 patients, 38-53 years of age (median age 46 years), with superficial lesions involving the glans penis, coronary sulcus, or shaft skin. After clinical staging and grading, those patients were offered a glans-preserving procedure to preserve the normal appearance and functional integrity of the glans penis. Of the 12 patients referred, the tumors were TaG1 in 4 patients, TaG2 in 3, TisG1 in 1, TisG2 in 1, T1G1 in 2, and T1G2 in 1. All patients returned to normal sexual activity 1 month postoperatively. Sexual function and sexual satisfaction were well maintained after surgery. The cosmetic results were considered satisfying/very satisfying by 83% (10 of 12 patients). Follow-up data were available on 12 patients at a mean follow-up of 62.5 months. Only 1 patient had recurrence 6 months after surgery, which was managed by a second glans-preserving surgery without recurrence. With careful patient selection and vigilant follow-up, anatomically suitable superficial penile cancer can be offered this glans-preserving surgery, while preserving function of the penis wherever possible.

  12. A Study of Superficial Mycosis in South Gujarat Region

    Directory of Open Access Journals (Sweden)

    Parul Patel, Summaiya Mulla, Disha Patel, Gaurishankar Shrimali

    2010-12-01

    Full Text Available Aim: To know the seroprevalence of clinical pattern of dermatophytosis and non – dermatophytic fungi (superficial mycosis with most common fungal pathogen in the South Gujarat region of the India. Methods: A clinical and mycological study of superficial mycosis was conducted on 198 cases (127 male and 71 female. Direct microscopy by KOH mount and culture was undertaken to isolate the fungal pathogen in each case. Results: 123 out of 198 cases (62.12% were positive by direct microscopy in which 58 (29.29% were positive by culture. The commonest age group involved was 21 – 30 years. Tinea corporis was the most common clinical presentation and Trichopyton rubrum was the most common fungal pathogen isolated. Non dermatophytic fungus like pityriasis versicolor and yeast like candida species were isolated in 17(22.67% cased and 8 (10.67% cases respectively. Conclusion: It was concluded that along with dermatophytes, nondermatophytic fungi are also emerging as important causes of superficial mycosis.

  13. Caracterización físico-química de la superficie de 9 implantes dentales con 3 distintos tratamientos de superficie

    OpenAIRE

    Rodríguez Rius, Daniel; García Sabán, Francisco

    2005-01-01

    Existen diversos tratamientos de superficie aplicados a los implantes dentales. El objetivo del presente estudio es comparar las características físico-químicas de la superficie de implantes dentales de titanio sometidos a diversos tratamientos de superficie. 9 implantes dentales procedentes del mismo lote de fabricación fueron separados en 3 grupos y sometidos a 3 tipos de tratamiento de superficie diferentes: mecanizado, grabado ácido y un ataque químico denominado Avan...

  14. Blending Parametric Patches with Subdivision Surfaces

    Institute of Scientific and Technical Information of China (English)

    李桂清; 李华

    2002-01-01

    In this paper the problem of blending parametric surfaces using subdivision patches is discussed. A new approach, named removing-boundary, is presented to generate piecewise-smooth subdivision surfaces through discarding the outmost quadrilaterals of the open meshes derived by each subdivision step. Then the approach is employed both to blend parametric bicubic B-spline surfaces and to fill n-sided holes. It is easy to produce piecewisesmooth subdivision surfaces with both convex and concave corners on the boundary, and limit surfaces are guaranteed to be C2 continuous on the boundaries except for a few singular points by the removing-boundary approach. Thus the blending method is very efficient and the blending surface generated is of good effect.

  15. Polar Dunes In Summer Exhibit Frost Patches, Wind Streaks

    Science.gov (United States)

    1999-01-01

    Mars Global Surveyor passes over the north polar region of the red planet twelve times each day, offering many opportunities to observe how the polar cap frosts and dunes are changing as the days goby. Right now it is summer in the north. This picture, taken the second week of April 1999, shows darks and dunes and remnant patches of bright frost left over from the winter that ended in July 1998. Dark streaks indicate recent movement of sand. The picture covers an area only 1.4 kilometers (0.9 miles)across and is illuminated from the upper right. Malin Space Science Systems and the California Institute of Technology built the MOC using spare hardware from the Mars Observer mission. MSSS operates the camera from its facilities in San Diego, CA. The Jet Propulsion Laboratory's Mars Surveyor Operations Project operates the Mars Global Surveyor spacecraft with its industrial partner, Lockheed Martin Astronautics, from facilities in Pasadena, CA and Denver, CO.

  16. TRANSDERMAL PATCHES: A SYNERGISTIC APPROACH OF DRUG DELIVERY FOR NSAIDs

    Directory of Open Access Journals (Sweden)

    Pragya* and V. Rastogi

    2012-09-01

    Full Text Available Transdermal drug delivery system has been accepted as potential non-invasive route of drug administration, with advantages of prolonged therapeutic effect, reduced side effects, improved bioavailability, better patient compliance and easy termination of drug therapy. Non-steroidal anti-inflammatory drugs (NSAIDs represents the most commonly used medications for the treatment of pain and inflammation, but numerous well-described side effects can limit their use. Therefore transdermal delivery of NSAIDs has advantages of avoiding hepatic first pass effect, gastric irritation and delivering the drug for extended period of time at a sustained level. The present article gives the brief view on the work been done on various NSAIDs by formulated and delivered as transdermal patches to decrease the side effects associated with the oral delivery. The various NSAIDs included in this article include Ketoprofen, Ibuprofen, Naproxen, Fluribrofen, Diclofenac, Aceclofenac, Ketorolac, Indomethacin, Meloxicam, Nimesulide, Celecoxib, Etoricoxib.

  17. BCG and the treatment of superficial bladder cancer.

    Science.gov (United States)

    Moss, J T; Kadmon, D

    1991-12-01

    In this report, we review the evolution of bacillus Calmette-Guérin (BCG) immunotherapy as a legitimate form of treatment in superficial, nonmuscle-invasive bladder cancer. In the US, an estimated 45,000 new cases of bladder cancer are diagnosed each year and the annual death rate approaches 11,000. Approximately 70 percent of these cancers are superficial at the time of initial presentation. The treatment of superficial bladder cancer has three objectives: (1) eradication of existing disease, (2) prophylaxis against tumor recurrence, and (3) prevention of tumor progression (either muscular invasion, metastatic spread, or both). Cystectomy generally is reserved for muscle-invasive disease. Transurethral resection of the bladder tumor is the preferred initial therapy. Intravesical instillations of various chemotherapeutic agents following transurethral resection have been extensively investigated. Some of the common agents used include thiotepa, mitomycin, and doxorubicin. Despite such treatment efforts, however, over 40 percent of patients with superficial bladder cancer experience a recurrence of their tumor within three years. Approximately half of these recurrences either present as less-well-differentiated tumors or have already penetrated into the bladder musculature, metastasized, or both. Since Morales et al. first introduced intravesical BCG vaccine for prophylaxis as well as for treatment of superficial bladder tumors in 1976, support has grown rapidly for its use as an alternative to chemotherapy. When used with prophylactic intent following transurethral resection, recurrence rates are lower than those achieved with other agents. In addition, BCG is emerging as the consensus drug of choice for treating carcinoma in situ of the bladder. The mechanisms by which BCG exerts its antitumor activity remain largely unknown. BCG is thought to stimulate a localized, nonspecific inflammatory response that leads to subsequent shedding of tumor cells. A large body

  18. Development of a Lithocodium (syn. Bacinella irregularis-reef-mound- A patch reef within Middle Aptian lagoonal limestone sequence near Nova Gorica (Sabotin Mountain, W-Slovenia

    Directory of Open Access Journals (Sweden)

    Roman Koch

    2002-06-01

    Full Text Available A Middle-Aptian (zone of Palorbitolina lenticularis „patch reef“ of about 40 m maximum thickness with marked morphology was analyzed at the Sabotin Mountain near Nova Gorica. It is developed above an basal unit of superficial oolites within lagoonal sediments and is overlain by shallow subtidal to intertidal sediments which reveal short time periodically subaerial exposure and early diagenetic freshwater influxes (birds eyes, vadose silt, characeans. Above these sediments within the zone of Salpingoporella dinarica finebedded to platy, laminated bituminous limestones occur.The central part of the reef structure reveals an alternation of individual lenses of Lithocodium-boundstones and of rudist-beds (up to 4 m thickness which are separated by coarse- to medium-grained, moderately to poorly sorted bioclastic sands. These faciestypes show also lateral interfingering and are concentrated in the central part of the buildup where the greatest thickness can be observed and where packstones, grainstones and boundstones prevail. The neighbouring lagoonal sediments which consist of mudstonesand wackestones predominantly were analyzed in the so-called Sabotin-standardprofile which is located north of the patch reef at a lateral distance of about 300 m.Three vertical profiles (A = 90 m, B = 100 m, C = 64 m thickness were analyzed. The middle profile B of greatest thickness is taken as reference profile and documents best the vertical facies development within the patch reef directly overlying a basal unit of peloidal packstones with superficial ooids. The patch reef itself is characterized by the faunal associations within the unit rich in Lithocodium and rudists. It is overlain by a subtidal unit of peloidal mudstones with very minor biogenic allochems. An intertidal unit above rich in birds-eyes and vadose silt is followed by fine-laminated black shales which are covering the general seqeunce of interfingering patch-reef – lagoonal sediments

  19. Evaluation of the litcit software for thermal simulation of superficial lasers such as hair removal lasers

    Directory of Open Access Journals (Sweden)

    Shirkavand A

    2007-01-01

    Full Text Available Background and Objectives : In this study, we evaluate LITCIT software for its application as a thermal simulation software for superficial hair removal laser systems. Materials and Methods: Two articles were used as our references. Complete information regarding the tissues, such as optical/thermal properties and geometrical modeling and also the laser systems such as wavelength, spot size, pulse duration and fluence were extracted from these texts. Then, this information regarding the tissues and systems was entered into the LITCIT simulation software. Further, we ran the program and saved the results. Finally, we compared our results with the results in references and evaluated the. Results : Output results of the LITCIT show that they are consistent with the results of references that were calculated with a different thermal modeling. Such a small average error shows the accuracy of the software for simulation and calculating the temperature. Conclusions : This simulating software has a good ability to be used as a treatment planning software for superficial lasers. Thus, it can be used for the optimization of treatment parameters and protocols.

  20. Acquisition and elaboration of superficial three-dimensional images in plastic and reconstructive surgery: Applications

    Directory of Open Access Journals (Sweden)

    Alfano C

    2005-01-01

    Full Text Available Since 1970, as computed axial tomography machines became easily available and became more sophisticated, image acquisition techniques and analysis improved, developed rapidly and became very useful in medical diagnosis. Today it is possible to examine either the anatomic and functional aspects of deep body organs and tissues including all the minute details as well as their morphological relations with superficial structures. Through precise graphic elaboration programs we can obtain information about spatial relations which was not possible using simply classical clinical examination. It is possible, for example, to "point out" an area of interest from its anatomic context, to carry out virtual cleavage of planes and to measure volumes and distances. New developments in image acquisition systems permit transfer of three-dimensional data directly from existing objects. The three -dimensional computerized axial tomography for deep structures, and the laser scanners for superficial structure, quickly furnish (1-3 seconds for the laser scanners useful information to plan the surgical operation. When analysing 3D-imaging techniques it is important to appreciate their utility for the planning and the follow up of surgery, particularly for the head and thorax, where the three dimensional evaluation is better than the classic double dimensional system that is incomplete and difficult to interpret. In the future, these systems will be important for the best aesthetic and functional results and above all for reducing the surgical time.

  1. Superficial perineal leiomyosarcoma in an adolescent female and a review of the literature including vulvar leiomyosarcomas

    DEFF Research Database (Denmark)

    Grove, A; Backman Nøhr, S

    1992-01-01

    differentiated and showed immunoreactivity for alpha-smooth muscle actin and desmin. A review of the literature on superficial leiomyosarcomas indicates that superficial perineal leiomyosarcomas may be more aggressive than superficial leiomyosarcomas in general. As the presented tumour occurred in a female......Superficial perineal leiomyosarcomas are rare, with only three previously reported examples. We encountered a superficial (deep subcutaneous) perineal leiomyosarcoma in a 17-year-old female. At follow-up two years after a wide excision, there were no signs of recurrence. The tumour was well...

  2. Development and in vitro evaluation of a transdermal hydrogel patch for ferulic acid.

    Science.gov (United States)

    Bai, Jie; Lu, Yang; Li, Peng-yue; Liu, Cong-min; Wu, Hui-chao; Wen, Ran; Du, Shou-ying

    2014-03-01

    Current work aimed to develop and evaluate a transdermal delivery system of hydrogel patch for ferulic acid to treat skin damage induced by UV radiation. VISCOMATE(TM) NP700, dihydroxy aluminium aminoacetate, glycerine, tartaric acid were used in combination in different ratios to design the hydrogel patch. In vitro release rate was selected as an index to optimize the formulation. The formulated hydrogel patch was evaluated by several parameters like tacking strength, cohesive strength, peeling strength, residuals after peeling and drug content determination. The in vitro penetration was determined by Franz diffusion technology with hairless mouse skin as permeability media. Different kinetics models were employed to simulate the release and penetrate patterns of ferulic acid from patches in order to investigate the drug transport mechanism. The residual drugs in the patch and skin were determined after the penetration experiment. The optimized preparation was dihydroxy aluminium aminoacetate: NP700: glycerine: ferulic acid as a ratio of 0.02:0.4:1.5:1.25:0.25. The cumulative percentage of release was 60.4465±1.7679% for 24h, which results from a combination of diffusion effect and polymer erosion effect. For the barrier of stratum corneum, the cumulative penetrate rate was only 1.3156±0.3588% and the release mechanism turn out to be the effect of erosion of polymer surface. The residual drugs in the patch were 97.5949±1.4932%. The in vitro data revealed that it was easy for ferulic acid to release from the paste while difficult to permeate through the skin barrier, which resulted in most of drugs residued in the paste. Hence, further experiments will be necessary for finding the penetration enhancer in ferulic acid transdermal delivery.

  3. Effect of a Low-Dose Contraceptive Patch on Efficacy, Bleeding Pattern, and Safety

    Science.gov (United States)

    Wiegratz, Inka; Bassol, Susana; Weisberg, Edith; Mellinger, Uwe

    2014-01-01

    This Phase III, uncontrolled, open-label, multicenter study was conducted to investigate the contraceptive efficacy, bleeding pattern, and cycle control of a novel once-a-week contraceptive patch, delivering low-dose ethinyl estradiol (EE) and gestodene (GSD) at the same systemic exposure seen after oral administration of a combined oral contraceptive containing 0.02 mg EE/0.06 mg GSD. Participants were women aged 18 to 35 years, all of whom received the EE/GSD patch for 13 cycles each of 21 treatment days (one patch per week for 3 weeks) followed by a 7-day, patch-free interval. The primary efficacy variable was the occurrence of unintended pregnancies during the study period as assessed by life table analysis and the Pearl Index. Secondary efficacy variables were days with bleeding during four 90-day reference periods and during 1 treatment year, bleeding pattern, and cycle control. The Kaplan-Meier probability of contraceptive protection after 364 treatment days was 98.8% and the adjusted Pearl Index was 0.81. The percentage of participants with intracyclic bleeding/spotting decreased over time, from 11.4% to 6.8% in cycles 1 and 12, respectively. Almost all participants (range: 90.8%-97.6%) experienced withdrawal bleeding across the study period. Compliance was very high (mean: 97.9%; median: 100%). The most frequent adverse events were headache (9.5%) and application site reaction (8.5%); no clinically significant safety concerns were observed. Results suggest the EE/GSD patch is highly effective in preventing pregnancy. Menstrual bleeding pattern was favorable and within the ranges expected of a healthy female population. The patch was well tolerated and treatment compliance was high. PMID:24784719

  4. The flexural stiffness of superficial neuromasts in the zebrafish (Danio rerio) lateral line.

    Science.gov (United States)

    McHenry, Matthew J; van Netten, Sietse M

    2007-12-01

    Superficial neuromasts are structures that detect water flow on the surface of the body of fish and amphibians. As a component of the lateral line system, these receptors are distributed along the body, where they sense flow patterns that mediate a wide variety of behaviors. Their ability to detect flow is governed by their structural properties, yet the micromechanics of superficial neuromasts are not well understood. The aim of this study was to examine these mechanics in zebrafish (Danio rerio) larvae by measuring the flexural stiffness of individual neuromasts. Each neuromast possesses a gelatinous cupula that is anchored to hair cells by kinocilia. Using quasi-static bending tests of the proximal region of the cupula, we found that flexural stiffness is proportional to the number of hair cells, and consequently the number of kinocilia, within a neuromast. From this relationship, the flexural stiffness of an individual kinocilium was found to be 2.4 x 10(-20) N m2. Using this value, we estimate that the 11 kinocilia in an average cupula generate more than four-fifths of the total flexural stiffness in the proximal region. The relatively minor contribution of the cupular matrix may be attributed to its highly compliant material composition (Young's modulus of approximately 21 Pa). The distal tip of the cupula is entirely composed of this material and is consequently predicted to be at least an order of magnitude more flexible than the proximal region. These findings suggest that the transduction of flow by a superficial neuromast depends on structural dynamics that are dominated by the number and height of kinocilia.

  5. Achieving Maximal Speed of Solution Exchange for Patch Clamp Experiments

    Science.gov (United States)

    Auzmendi, Jerónimo; Fernández Do Porto, Darío; Pallavicini, Carla; Moffatt, Luciano

    2012-01-01

    Background Resolving the kinetics of agonist binding events separately from the subsequent channel gating processes requires the ability of applying and removing the agonist before channel gating occurs. No reported system has yet achieved pulses shorter than 100 µs, necessary to study nicotinic ACh receptor or AMPA receptor activation. Methodology/Principal Findings Solution exchange systems deliver short agonist pulses by moving a sharp interface between a control and an experimental solution across a channel preparation. We achieved shorter pulses by means of an exchange system that combines a faster flow velocity, narrower partition between the two streams, and increased velocity and bandwidth of the movement of the interface. The measured response of the entire system was fed back to optimize the voltage signal applied to the piezoelectric actuator overcoming the spurious oscillations arising from the mechanical resonances when a high bandwidth driving function was applied. Optimization was accomplished by analyzing the transfer function of the solution exchange system. When driven by optimized command pulses the enhanced system provided pulses lasting 26 ± 1 µs and exchanging 93 ± 1% of the solution, as measured in the open tip of a patch pipette. Conclusions/Significance Pulses of this duration open the experimental study of the molecular events that occur between the agonist binding and the opening of the channel. PMID:22879927

  6. Argus II retinal prosthesis implantation with scleral flap and autogenous temporalis fascia as alternative patch graft material: a 4-year follow-up

    Directory of Open Access Journals (Sweden)

    Matet A

    2016-08-01

    Full Text Available Alexandre Matet,1,2 Nawel Amar,1,2 Saddek Mohand-Said,1–4 José-Alain Sahel,1–7 Pierre-Olivier Barale1,2 1INSERM and DHOS, CHNO des Quinze-Vingts, 2Sorbonne Universités, UPMC Univ Paris 6, Institut de la Vision, 3INSERM, 4CNRS, Paris, France; 5Institute of Ophthalmology, University College London, London, UK; 6Fondation Ophtalmologique Adolphe de Rothschild, 7Académie des Sciences, Institut de France, Paris, France Introduction: The Argus II retinal prosthesis is composed of an epiretinal electrode array positioned over the macula and connected to an extrascleral electronics case via a silicone cable, running through a sclerotomy. During implantation, the manufacturer recommends to cover the sclerotomy site with a patch of processed human pericardium to prevent postoperative hypotony and conjunctival erosion by the underlying electronics case. Due to biomedical regulations prohibiting the use of this material in France, we developed an alternative technique combining a scleral flap protecting the sclerotomy and an autogenous graft of superior temporalis fascia overlying the electronics case. Methods: The purpose of this study is to describe the 4-year outcomes of this modified procedure in three subjects who underwent Argus II Retinal Prosthesis System implantation. Clinical data consisting of intraocular pressure measurements and tolerance in terms of conjunctival erosion or inflammation were retrospectively assessed over a 4-year postoperative follow-up. Results: None of the three patients implanted with the modified technique developed ocular hypotony over 4 years. A normal, transient conjunctival inflammation occurred during the first postoperative month but conjunctival erosion was not observed in any of the three patients over 4 years. Four years after implantation, the autogenous temporalis fascia graft remained well tolerated and the retinal prosthesis was functional in all three patients. Conclusion: The combination of an

  7. Texture synthesis via the matching compatibility between patches

    Institute of Scientific and Technical Information of China (English)

    WANG WenCheng; LIU FeiTong; HUANG PeiJie; WU EnHua

    2009-01-01

    A new patch-based texture synthesis method is presented in this paper.By the method,a set of patches that can be matched with a sampled patch for growing textures effectively,called the matching compatibility between patches,is generated first for each patch,and the set is further optimized by culling the patches that may cause synthesis conflicts.In this way,similarity measurement calculation for selecting suitable patches in texture synthesis can be greatly saved,and synthesis conflicts between neighbouring patches are substantially reduced.Furthermore,retrace computation is Integrated in the synthesis process to improve the texture quality.As a result,the new method can produce high quality textures as texture optimization,the best method to date for producing good textures,and run in a time complexity linear to the size of the output texture.Experimental results show that the new method can interactively generate a large texture in 1024 × 1024 pixels,which is very difficult to achieve by existing methods.

  8. Hydrophobic patches on the surfaces of protein structures

    NARCIS (Netherlands)

    Lijnzaad, P.; Berendsen, H.J.C.; Argos, P.

    1996-01-01

    A survey of hydrophobic patches on the surface of 112 soluble, monomeric proteins is presented, The largest patch on each individual protein averages around 400 Angstrom(2) but can range from 200 to 1,200 Angstrom(2). These areas are not correlated to the sizes of the proteins and only weakly to the

  9. Trends and developments in two decades of patch testing

    NARCIS (Netherlands)

    Christoffers, W.A.; Schuttelaar, M.-L.A.; Coenraads, P.J.

    2013-01-01

    Introduction: Allergic contact dermatitis is a common condition with an estimated lifetime prevalence of 19.5%. The diagnosis is confirmed by patch tests. This study aims to visualise trends and developments in patch testing over 23 years and to evaluate the influence of legal restrictions with spec

  10. Phosphorus leaching from cow manure patches on soil columns

    NARCIS (Netherlands)

    Chardon, W.J.; Aalderink, G.H.; Salm, van der C.

    2007-01-01

    The loss of P in overland flow or leachate from manure patches can impair surface water quality. We studied leaching of P from 10-cmhigh lysimeters filled with intact grassland soil or with acid-washed sand. A manure patch was created on two grassland and two sandfilled lysimeters, and an additional

  11. Organic transdermal iontophoresis patch with built-in biofuel cell.

    Science.gov (United States)

    Ogawa, Yudai; Kato, Koichiro; Miyake, Takeo; Nagamine, Kuniaki; Ofuji, Takuya; Yoshino, Syuhei; Nishizawa, Matsuhiko

    2015-03-11

    A completely organic iontophoresis patch is reported. A built-in biofuel cell is mounted on the patch that generates transdermal iontophoretic administration of compounds into the skin. The amplitude of transdermal current is tuned by integrating a conducting polymer-based stretchable resistor of predetermined resistance.

  12. SIERPIENSKI & CROWN SQUARE FRACTAL SHAPES SLOTTED MICROSTRIP PATCH ANTENNA

    Directory of Open Access Journals (Sweden)

    Dr. Yogesh Bhomia

    2014-01-01

    Full Text Available A new Sierpienski & Crown Square Fractal Shapes Slotted Microstrip Patch Antenna is proposed. A patch antenna is a narrowband, wide-beam antenna. These antennas are low profile, conformal to planar and non-planar surface, simple and inexpensive to manufacture using modern printed circuit technology, mechanically robust when mounted on rigid surface, compatible with MMIC designs and when the particular shape and mode are selected they are very versatile in terms of resonant frequency, polarization, field pattern and impedance. Microstrip patch antenna consist of a very thin metallic strip (patch placed a small fraction of a wavelength above a ground plane. The patch is generally made of conducting material such as copper or gold and can take any possible shape. This paper presents a design of Sierpienski & Crown Square Fractal Shapes Slotted Microstrip Patch Antenna and experimentally studied on IE3D software. This design is achieved by cutting Sierpienski & Crown Square Fractal Shapes Slottes in a patch. With Sierpienski & Crown Square Fractal Shapes patch antenna is designed on a FR4 substrate of thickness 1.524 mm and relative permittivity of 4.4 and mounted above the ground plane at a height of 6 mm. Bandwidth as high as 36.6% are achieved with stable pattern characteristics, such as gain and cross polarization, within its bandwidth. Impedance bandwidth, antenna gain and return loss are observed for the proposed antenna. Details of the measured and simulated results are presented and discussed.

  13. Superficially, longer, intermittent ozone theraphy in the treatment of the chronic, infected wounds.

    Science.gov (United States)

    Białoszewski, Dariusz; Kowalewski, Michał

    2003-10-30

    Background. Ozone therapy - i.e. the treatment of patients by a mixture of oxygen and ozone - has been used for many years as a method ancillary to basic treatment, especially in those cases in which traditional treatment methods do not give satisfactory results, e.g. skin loss in non-healing wounds, ulcers, pressure sores, fistulae, etc. Material and methods. In the Department of Phisiotherapy of the Medical Faculty and the Department of the Orthopedics and Traumatology of the Locomotor System at the Medical University of Warsaw in the period from January 2001 until November 2002, 23 patients with heavy,chronic, antibiotic resistants septic complications after trauma, surgical procedures and secundary skin infetions were treated with ozone. The ozone therapy was administered using an authorial technique of superficially, longer, intermittent ozone application. Results. In the wounds of the all experienced patients the inhibition of septic processes and wound healing was much faster than normal. Conclusions. Our data confirm the advantages wich result from the technique of superficially, longer, intermittent ozone theraphy in combined treatment for septic complications in the soft tissue, especially in the locomotor system. These technique makes posttraumatic infections and promotes quicker healing of post-surgical and post-traumal complications - chronic septic infections. This method also lowers the cost of antibiotic therapy and is sometimes the only available auxiliary technique to support surgical procedures.

  14. Performance of NBPE in Rectangular Microstrip Patch Antenna

    Directory of Open Access Journals (Sweden)

    Tushar

    2014-02-01

    Full Text Available In this paper we use a rectangular microstrip patch antenna with fed patch contains four notches of equal Length and width (L×W and having one parasitic patch, to achieve dual band operation of proposed microstrip patch antenna, is analyzed using circuit theory concept. The theoretical and simulated results of proposed antenna are compared. The return loss of NBPE using rectangular microstrip patch antenna decreased and bandwidth at dual operating frequency 1.44 GHz & 1.80 GHz are increased at a substrate height of 1.6 mm. This paper shows the decreased in return loss & improves in Gain as well as bandwidth using NBPE. These structures are simulated using IE3D version 12.29 Zeland software incorporation.

  15. Analysis of a multi patch dynamical model about cattle brucellosis

    Directory of Open Access Journals (Sweden)

    Juan Zhang

    2014-10-01

    Full Text Available The dissemination of cattle brucellosis in Zhejiang province of China can be attributed to the transport of cattle between cities within the province. In this paper,an n-patch dynamical model is proposed to study the effect of cattle dispersal on brucellosis spread. Theoretically,we analyze the dynamical behavior of the muti-patch model. For the 2-patch submodel,sensitivity analyses of the basic reproduction number R0 and the number of the infectious cattle in term of model parameters are carried out. By numerical analysis,it is obtained that the dispersal of susceptible cattle between patches and the centralization of infected cattle to the large scale patch can alleviate the epidemic and are in favor of the control of disease in the whole region.

  16. Nickel patch test reactivity and the menstrual cycle

    DEFF Research Database (Denmark)

    Rohold, A E; Halkier-Sørensen, L; Thestrup-Pedersen, K;

    1994-01-01

    Premenstrual exacerbation of allergic contact dermatitis and varying allergic patch test responses have been reported at different points of the period. Using a dilution series of nickel sulphate, we studied the variation in patch test reactivity in nickel allergic women in relation...... to the menstrual cycle. Twenty women with regular periods were tested on day 7-10 and on day 20-24. Ten nickel patch tests with different concentrations were applied using the TRUE test assay, and the threshold concentration of nickel sulphate eliciting an erythematous reaction was determined. Half of the women...... an increased nickel sensitivity at the second patch test (0.02 nickel sulphate patch tests premenstrually in 20 nickel allergic women, but we found that elicitation...

  17. Dual-Band Microstrip Patch Antenna Miniaturization Using Metamaterial

    Directory of Open Access Journals (Sweden)

    Indrasen Singh

    2013-01-01

    Full Text Available A dual-band microstrip patch antenna is designed and analyzed using metamaterial artificial substrate. Metamaterial based substrate is designed using Square Split Ring Resonator (SSRR and Wire Strip. The antenna is tuned to work at two resonating frequencies in the frequency range from 1 GHz to 4 GHz depending on the geometric specifications of SSRR, strip line, radiating patch, and feed location point. Proposed antenna provides good return loss behavior at both resonating frequencies. The obtained VSWR at both resonating frequencies is very much near to 1. Proposed antenna covers applications in mobile communication and Wi-MAX. Proposed patch antenna is compared with the conventional patch antenna, which shows the significant miniaturization as compared to conventional patch antenna.

  18. Formulation and Characterization of Transdermal Patches of Losartan

    Directory of Open Access Journals (Sweden)

    Ujjawal Nautiyal*1, Devendra Singh2

    2013-03-01

    Full Text Available Administration of drugs through skin has received great attention through the last decade. Hence this study aims to formulate an anti-hypertensive drug losartan as transdermal patch using different bioadhesive polymers such as ethyl cellulose, cellulose acetate, and polyvinyl pyrrolidon,hydroxyl propylemethylcellulose with plasticizers propylene glycol (PG. Patches were prepared though solvent evaporation method, The backing membrane was a non permeable aluminium foil laminated with polyethylene and evaluated for thickness uniformity, Uniformity of weight, Scanning Electron Microscopy, Surface pH, Swelling studies, Drug content uniformity Effect on agingn, skin irritation potential, and In vitro release study.Patches exhibited controlled release over more than 2 hr.It was concluded that patches containing 30 mg of losartane with HPMC (formulation F2 ,showed moderate swelling, surface pH and controlled drug release, thus can be selected for the development of transdermal patches for effective uses.

  19. Low-Power Optically Controlled Patch Antenna of Reconfigurable Beams

    Directory of Open Access Journals (Sweden)

    Deshuang Zhao

    2014-01-01

    Full Text Available A novel compact beam-reconfigurable patch antenna based on light control of no more than 30 mW optical powers is successfully demonstrated. It consists of one T-shape driven patch and one slot-etched parasitic patch. A silicon dice is employed as the photoconductive switch that is bridged across the slot center for optical control of reconfigurable beams. The antenna greatly reduces the total optical powers required for reconfigurable beams. Such design is based on the fact that the current phase change of the parasitic patch is sensitive to the conductivity of the silicon dice. A few conductivity changes of the silicon dice induced by the optical light can lead to a big phase change of the parasitic patch currents, eventually resulting in reconfigurable beams with low optical power requirement.

  20. Circumferential phased array of shear-horizontal wave magnetostrictive patch transducers for pipe inspection.

    Science.gov (United States)

    Kim, Hoe Woong; Lee, Joo Kyung; Kim, Yoon Young

    2013-02-01

    Several investigations report effective uses of magnetostrictive patch transducers to generate and measure longitudinal and torsional guided waves in a pipe. They can be used to form a phased array for the circumferential inspection of pipes. Although there are circumferential phased arrays employing piezoelectric transducers or EMAT's, no magnetostrictive patch transducer based array system has been attempted. In this investigation, we aim to develop a circumferential phased magnetostrictive patch transducer (PMPT) array that can focus shear-horizontal waves at any target point on a cylindrical surface of a pipe. For the development, a specific configuration of a PMPT array employing six magnetostrictive patch transducers is proposed. A wave simulation model is also developed to determine time delays and amplitudes of signals generated by the transducers of the array. This model should be able to predict accurately the angular profiles of shear-horizontal waves generated by the transducers. For wave focusing, the time reversal idea will be utilized. The wave focusing ability of the developed PMPT array is tested with multiple-crack detection experiments. Imaging of localized surface inspection regions is also attempted by using wave signals measured by the developed PMPT array system.

  1. Performance Enhancement of Patch-based Descriptors for Image Copy Detection

    Directory of Open Access Journals (Sweden)

    Junaid Baber

    2016-03-01

    Full Text Available Images have become main sources for the informa-tion, learning, and entertainment, but due to the advancement and progress in multimedia technologies, millions of images are shared on Internet daily which can be easily duplicated and redistributed. Distribution of these duplicated and transformed images cause a lot of problems and challenges such as piracy, redundancy, and content-based image indexing and retrieval. To address these problems, copy detection system based on local features are widely used. Initially, keypoints are detected and represented by some robust descriptors. The descriptors are computed over the affine patches around the keypoints, these patches should be repeatable under photometric and geometric transformations. However, there exist two main challenges with patch based descriptors, (1 the affine patch over the keypoint can produce similar descriptors under entirely different scene or the context which causes “ambiguity”, and (2 the descriptors are not enough “distinctive” under image noise. Due to these limitations, the copy detection systems suffer in performance. We present a framework that makes descriptor more distinguishable and robust by influencing them with the texture and gradients in vicinity. The experimental evaluation on keypoints matching and image copy detection under severe transformations shows the effectiveness of the proposed framework.

  2. Hybridization quality in cervical cementum and superficial dentin using current adhesives.

    Science.gov (United States)

    Yuan, Yang; Shimada, Yasushi; Ichinose, Shizuko; Tagami, Junji

    2008-05-01

    The aim of this research was to determine the hybridization quality of adhesives to gingival cementum and close superficial dentin using both total-etch and self-etch, one-step and two-step adhesives in vitro. Five adhesive systems were used and evaluated in this study; three kinds of two-step adhesives (total-etch--Single Bond and self-etch--Clearfil SE Bond and Clearfil Protect Bond) and two one-step adhesives (Clearfil S3 Bond, G Bond). Fifteen extracted intact human third molars were used in this study. A diagonal cut which was approximately 45 degrees to the long axis of the roots, with the initiating point located 2 mm below the buccal enamel-cementum junction and ascending towards the pulp chamber was prepared on each tooth. Flat cervical cementum and dentin surfaces were ground with wet 600-grit silicon carbide paper, and bonded with one of the adhesives and finished by applying a flowable resin composite. After 24 h storage at 37 degrees C in water, the bonded assemblies were sectioned into approximately 1mm thick slabs. Two central slabs from each tooth were chosen. One slab was totally demineralized in 0.5 M EDTA and the other was not demineralized and immersed into 50% (w/v) solution of ammoniacal silver nitrate for 24 h, and successively exposed to photodeveloping solution for 8 h. The specimens were then processed for TEM observation. Both the stained demineralized silver unchallenged and unstained non-demineralized silver challenged resin-cervical cementum/proximal superficial dentin interface were observed and evaluated under a transmission electron microscope. The nanoleakage pathway and extent vary among the different adhesives used and also between the resin-cementum interface and resin-dentin interface. Two-step self-etch adhesives showed better hybridization quality both in cementum and proximal superficial dentin as compared to those of two-step total-etch adhesive and one-step self-etch adhesives. Two-step self-etch adhesives may provide a

  3. Ingeniería de superficies y su impacto medioambiental

    Directory of Open Access Journals (Sweden)

    Agüero, A.

    2007-02-01

    Full Text Available Surface engineering addresses the modification of the microstructure and/or composition of the surface of components by mechanical, physical or chemical methods that may imply adding a material in order to change the surface properties of said component. One of its most important consequences is the significant increase of the useful life of a variety of components in a large number of industrial applications. Moreover, it contributes to energy savings by increasing efficiencies as it allows higher combustion temperatures, by allowing the use of lighter components and by significant friction reduction. In this paper, surface engineering is introduced, as well as its different modalities, examples of industrial applications and positive and negative environmental impacts.

    La ingeniería de superficies consiste en la modificación de la microestructura y/o la composición superficial de un componente mediante métodos mecánicos, físicos o químicos, que pueden implicar el aporte de otro material para cambiar las propiedades superficiales del mencionado componente. Una de sus consecuencias más importantes es que permite alargar significativamente, la vida útil de todo tipo de componentes empleados en un gran número de aplicaciones industriales. Por otra parte, contribuye al ahorro energético por permitir el aumento de las temperaturas de combustión consiguiendo una mayor eficiencia, por contribuir a la reducción de peso y por colaborar de forma significativa a disminuir la fricción entre componentes. En el presente trabajo se introduce la ingeniería de superficies, sus diferentes modalidades, algunos ejemplos de sus aplicaciones industriales y las interacciones, positivas y negativas, con el medio ambiente.

  4. Endoscopic mucosectomy: an alternative treatment for superficial esophageal cancer.

    Science.gov (United States)

    Lambert, R

    2000-01-01

    Recent trends in the management of superficial esophageal cancer consist of improved detection, pretherapeutic staging and reliable criteria for curative endoscopic therapy. The endoscopic treatment is legitimate when the cancer is at an early stage, intra-epithelial or microinvasive (m1 or m2) and N0. Submucosal cancer should not be treated with a curative intent by endotherapy. Concerning squamous cell cancer, the oriental and occidental pathologists include high-grade dysplasia in the same group as intramucosal cancer. The distinction is however maintained for adenocarcinoma in the Barrett's esophagus. Indications of endoscopic rather than surgical treatment rely on: (1) the small size of the tumor (not more than 2 cm in diameter); (2) the endoscopic morphology in the type 0 of the Japanese classification with the flat subtypes IIa and IIb rather than type IIc--there is high risk of submucosal invasion for the polypoid (type I) or ulcerated superficial cancer (type III); and (3) the endoscopic ultrasound staging, with confirmed integrity of the hyperechoic submucosal layer. The high-frequency (20 MHz) miniprobe is preferred to the standard (7.5 MHz) instrument. The elective procedure for tumor eradication is endoscopic mucosectomy. The technique is associated with a 6.8% risk of severe complications (hemorrhage or perforation) and a recurrence rate of 3%-7%. The 5-year survival rate is similar to that of surgery (over 80%). In the small group of patients with superficial esophageal cancer (less than 10% of the disease) endoscopic treatment may now be proposed in about 30% of cases, surgery is preferred for submucosal cancer and for neoplasia with a large surface. Areas of high-grade dysplasia in the Barrett's esophagus offer a new and increasing sector of indications. The concurrent endoscopic procedure of destruction--photodynamic therapy--is preferred for the destruction of lesions with poorly delineated limits.

  5. Functional compartmentalization of the human superficial masseter muscle.

    Directory of Open Access Journals (Sweden)

    Rodrigo A Guzmán-Venegas

    Full Text Available Some muscles have demonstrated a differential recruitment of their motor units in relation to their location and the nature of the motor task performed; this involves functional compartmentalization. There is little evidence that demonstrates the presence of a compartmentalization of the superficial masseter muscle during biting. The aim of this study was to describe the topographic distribution of the activity of the superficial masseter (SM muscle's motor units using high-density surface electromyography (EMGs at different bite force levels. Twenty healthy natural dentate participants (men: 4; women: 16; age 20±2 years; mass: 60±12 kg, height: 163±7 cm were selected from 316 volunteers and included in this study. Using a gnathodynamometer, bites from 20 to 100% maximum voluntary bite force (MVBF were randomly requested. Using a two-dimensional grid (four columns, six electrodes located on the dominant SM, EMGs in the anterior, middle-anterior, middle-posterior and posterior portions were simultaneously recorded. In bite ranges from 20 to 60% MVBF, the EMG activity was higher in the anterior than in the posterior portion (p-value = 0.001.The center of mass of the EMG activity was displaced towards the posterior part when bite force increased (p-value = 0.001. The topographic distribution of EMGs was more homogeneous at high levels of MVBF (p-value = 0.001. The results of this study show that the superficial masseter is organized into three functional compartments: an anterior, a middle and a posterior compartment. However, this compartmentalization is only seen at low levels of bite force (20-60% MVBF.

  6. Functional compartmentalization of the human superficial masseter muscle.

    Science.gov (United States)

    Guzmán-Venegas, Rodrigo A; Biotti Picand, Jorge L; de la Rosa, Francisco J Berral

    2015-01-01

    Some muscles have demonstrated a differential recruitment of their motor units in relation to their location and the nature of the motor task performed; this involves functional compartmentalization. There is little evidence that demonstrates the presence of a compartmentalization of the superficial masseter muscle during biting. The aim of this study was to describe the topographic distribution of the activity of the superficial masseter (SM) muscle's motor units using high-density surface electromyography (EMGs) at different bite force levels. Twenty healthy natural dentate participants (men: 4; women: 16; age 20±2 years; mass: 60±12 kg, height: 163±7 cm) were selected from 316 volunteers and included in this study. Using a gnathodynamometer, bites from 20 to 100% maximum voluntary bite force (MVBF) were randomly requested. Using a two-dimensional grid (four columns, six electrodes) located on the dominant SM, EMGs in the anterior, middle-anterior, middle-posterior and posterior portions were simultaneously recorded. In bite ranges from 20 to 60% MVBF, the EMG activity was higher in the anterior than in the posterior portion (p-value = 0.001).The center of mass of the EMG activity was displaced towards the posterior part when bite force increased (p-value = 0.001). The topographic distribution of EMGs was more homogeneous at high levels of MVBF (p-value = 0.001). The results of this study show that the superficial masseter is organized into three functional compartments: an anterior, a middle and a posterior compartment. However, this compartmentalization is only seen at low levels of bite force (20-60% MVBF).

  7. Does the patch fit the stoma? A study on peristoma geometry and patch use in laryngectomized patients

    NARCIS (Netherlands)

    van der Houwen, E. B.; van Kalkeren, T. A.; Post, W. J.; Hilgers, F. J. M.; van der Laan, B. F. A. M.; Verkerke, G. J.

    2011-01-01

    Objective: To determine the geometry of (peri) stomas of laryngectomised patients in relation to patch use. This data will enable improvement of tracheostoma interfaces, specifically addressing patients currently unable to use stoma patches. The low use of Heat-and-Moisture-Exchange (HME) filters an

  8. Does the patch fit the stoma? A study on peristoma geometry and patch use in laryngectomized patients

    NARCIS (Netherlands)

    van der Houwen, E.B.; van Kalkeren, T.A.; Post, W.J.; Hilgers, F.J.M.; van der Laan, B.F.A.M.; Verkerke, G.J.

    2011-01-01

    Objective: To determine the geometry of (peri)stomas of laryngectomised patients in relation to patch use. This data will enable improvement of tracheostoma interfaces, specifically addressing patients currently unable to use stoma patches. The low use of Heat-and-Moisture-Exchange (HME) filters and

  9. GLOBAL STABILITY OF EXTENDED MULTI-GROUP SIR EPIDEMIC MODELS WITH PATCHES THROUGH MIGRATION AND CROSS PATCH INFECTION

    Institute of Scientific and Technical Information of China (English)

    Yoshiaki MUROYA; Yoichi ENATSU; Toshikazu KUNIYA

    2013-01-01

    In this article,we establish the global stability of an endemic equilibrium of multi-group SIR epidemic models,which have not only an exchange of individuals between patches through migration but also cross patch infection between different groups.As a result,we partially generalize the recent result in the article [16].

  10. Composicion y deformacion de curvas, superficies y volumenes de bezier

    OpenAIRE

    Canchoa Quispe, Alessandri

    1998-01-01

    El presente trabajo enfoca el problema de la composición y deformación de cla¬vas, superficies y volúmenes de Bézier. Los algoritmos para encontrar los puntos de control de la composición (F=Fog) de simplejos o formas de producto tensorial de Bézier g:Rn -> RwyF:RN->Rd a partir de los puntos de control de g y F tienen aplicaciones práctica en el CAGD (Computer Aided Geometric Design). Estos algoritmos inicialmente fue presentado por DeRose [DeRo 88]: el algoritmo producto para la deformación ...

  11. Aneurysm of the superficial palmar arch: a case report.

    Science.gov (United States)

    Estrella, Emmanuel P; Lee, Ellen Y

    2008-01-01

    Aneurysms of the hand are uncommon lesions. The most common location is the ulnar artery. We present a case of a young female who consulted us for a hand mass with a history of trauma to the hand. Pre-operative arteriogram showed a superficial palmar arch aneurysm. The mass was excised and the arch was reconstructed using a reversed Y-shaped vein graft. Fourteen months after surgery, there was no recurrence of the aneurysm and the patient only reported occasional cold intolerance.

  12. Endoscopic and biopsy diagnoses of superficial, nonampullary, duodenal adenocarcinomas

    Science.gov (United States)

    Kakushima, Naomi; Kanemoto, Hideyuki; Sasaki, Keiko; Kawata, Noboru; Tanaka, Masaki; Takizawa, Kohei; Imai, Kenichiro; Hotta, Kinichi; Matsubayashi, Hiroyuki; Ono, Hiroyuki

    2015-01-01

    AIM: To investigate the accuracy of endoscopic or biopsy diagnoses of superficial nonampullary duodenal epithelial tumors (NADETs). METHODS: Clinicopathological data were reviewed for 84 superficial NADETs from 74 patients who underwent surgery or endoscopic resection between September 2002 and August 2014 at a single prefectural cancer center. Superficial NADETs were defined as lesions confined to the mucosa or submucosa. Demographic and clinicopathological data were retrieved from charts, endoscopic and pathologic reports. Endoscopic reports included endoscopic diagnosis, location, gross type, diameter, color, and presence or absence of biopsy. Endoscopic diagnoses were made by an endoscopist in charge of the examination before biopsy specimens were obtained. Endoscopic images were obtained using routine, front-view, high-resolution video endoscopy, and chromoendoscopy with indigocarmine was performed for all lesions. Endoscopic images were reviewed by at least two endoscopists to assess endoscopic findings indicative of carcinoma. Preoperative diagnoses based on endoscopy and biopsy findings were compared with histological diagnoses of resected specimens. Sensitivity, specificity, and accuracy were assessed for endoscopic diagnosis and biopsy diagnosis. RESULTS: The majority (81%) of the lesions were located in the second portion of the duodenum. The median lesion diameter was 14.5 mm according to final histology. Surgery was performed for 49 lesions from 39 patients, and 35 lesions from 35 patients were endoscopically resected. Final histology confirmed 65 carcinomas, 15 adenomas, and 3 hyperplasias. A final diagnosis of duodenal carcinoma was made for 91% (52/57) of the lesions diagnosed as carcinoma by endoscopy and 93% (42/45) of the lesions diagnosed as carcinoma by biopsy. The sensitivity, specificity, and accuracy of endoscopic diagnoses were 80%, 72%, and 78%, respectively, whereas those of biopsy diagnoses were 72%, 80%, and 74%, respectively

  13. SubPatch: random kd-tree on a sub-sampled patch set for nearest neighbor field estimation

    Science.gov (United States)

    Pedersoli, Fabrizio; Benini, Sergio; Adami, Nicola; Okuda, Masahiro; Leonardi, Riccardo

    2015-02-01

    We propose a new method to compute the approximate nearest-neighbors field (ANNF) between image pairs using random kd-tree and patch set sub-sampling. By exploiting image coherence we demonstrate that it is possible to reduce the number of patches on which we compute the ANNF, while maintaining high overall accuracy on the final result. Information on missing patches is then recovered by interpolation and propagation of good matches. The introduction of the sub-sampling factor on patch sets also allows for setting the desired trade off between accuracy and speed, providing a flexibility that lacks in state-of-the-art methods. Tests conducted on a public database prove that our algorithm achieves superior performance with respect to PatchMatch (PM) and Coherence Sensitivity Hashing (CSH) algorithms in a comparable computational time.

  14. Drug release and adhesive properties of crospovidone-containing matrix patches based on polyisobutene and acrylic adhesives.

    Science.gov (United States)

    Schulz, Martin; Fussnegger, Bernhard; Bodmeier, Roland

    2010-12-23

    Ethinyl estradiol and levonorgestrel were insoluble in blends of high:medium:low molecular weight polyisobutene adhesives (ratio: 1:5:0, 1:5:2 and 1:5:4) but soluble in acrylic adhesives (Durotak 87-202A, Durotak 87-2074 and Durotak 87-2677). The incorporation of drug adsorbates onto crospovidone into the polyisobutene blends yielded crystal-free patches. The drug release from these patches was independent of polyisobutene's molecular weight distribution, probably because the drug release occurred mainly through fluid filled channels. By contrast, the drug release from acrylic adhesives was independent of whether the patches contained pure drugs or drug adsorbates onto crospovidone. A higher degree of saturation (or supersaturation) in these systems resulted in a higher thermodynamic activity of the drugs and hence a higher drug release. The crystal-free acrylic and polyisobutene patches did not show drug recrystallization after 3 months at 25°C/60 RH and 40°C/75 RH. The adhesive properties of polyisobutene patches were investigated in vitro and in vivo. The area under the curve of force-distance curves recorded with the texture analyzer correlated well with the in vivo skin adhesion. The elongation at detachment showed the same trend as the in vivo matrix creep. Crospovidone contents ≤ 30% had no detrimental effect on the adhesive properties of the patches.

  15. A Study of Superficial Mycoses with Clinical Mycological Profile in Tertiary Care Hospital in Ahmedabad, Gujarat

    Directory of Open Access Journals (Sweden)

    Bhavsar Hitendra K

    2012-04-01

    Full Text Available Aims & objectives: Superficial mycoses are commonly encountered fungal diseases prevalent in most parts of the world. It is a fungal disease infecting hair, skin & nails. In most of the cases, it does not produce any symptoms but in some cases it has cosmetic & systemic complications. The present study was carried out to know the prevalence of various superficial fungal pathogens in our institute. Materials & Methods: In our study, a total of 377 samples from skin department were processed & all were examined by conventional direct KOH preparation & fungal culture methods. Identification of the species was done by Lactophenol Cotton Blue mount from colony smear. Results: in present study, males are infected more than females with a ratio of 2.14:1. Tinea corporis was the commonest clinical type (52.78%. The positivity rate of KOH preparation is 68.16% & of culture is 20.15%. Trichophyton rubrum is the commonest fungal isolate (35.26% followed by Trichophyton mentagrophytes. The maximum number of the cases was seen in the monsoon months. Conclusion: Male have higher fungal infection rate than females. Trichophyton rubrum is the common isolate in our geographical area. KOH preparation has higher positivity rate than culture. [National J of Med Res 2012; 2(2.000: 160-164

  16. Evaluating the Efficacy of a Sternocleidomastoid Flap via Galvanic Skin Responses in Superficial Parotidectomy.

    Science.gov (United States)

    Basut, Oguz; Noyan, Behzat; Demirci, Ugur

    2014-01-01

    In the present study, we evaluated the efficacy of flaps via measurement of galvanic skin responses (GSR) in patients who had undergone superficial parotidectomy either with or without sternocleidomastoid (SCM) muscle flaps. Retrospective study design was used. The setting included University of Uludag School of Medicine Department of Otorhinolaryngology. Eleven patients who had undergone superficial parotidectomy for benign diseases in our clinic between June 2003 and August 2006 were included in the study. SCM muscle flaps were used in four patients. The GSR of the patients were measured using a MP 30 System. The Mann-Whitney U test was used for the analysis of data. There were complaints that resembled Frey's syndrome in three patients in whom flaps had not been performed. Patients with flaps had no complaints. In patients with flaps, no significant GSR changes were observed between the control and operated sides (P > 0.05). In patients without flaps, the GSR levels were significantly higher on the operated side compared to the control side (P SCM flap is an efficient method by which to prevent Frey's syndrome, and the GSR test is beneficial both in diagnosiing and determining the severity of the disease as well as evaluating the efficacy of surgical techniques used to prevent Frey's syndrome.

  17. FORMULATION AND EVALUATION OF A MONOLITHIC DRUG-IN-ADHESIVE TYPE PATCH CONTAINING TENOXICAM

    Directory of Open Access Journals (Sweden)

    S. Ramkanth

    2015-04-01

    Full Text Available Tenoxicam (TX is a well-established nonsteroidal anti-inflammatory agent with analgesic actions achieved by inhibiting prostaglandin synthesis. Administration of tenoxicam through the transdermal route offers many advantages over the oral dosage form as it avoids the problems associated with the other routes of administration, such as improving patient compliance in long term therapy, bypassing first pass metabolism, sustaining drug delivery, maintaining a constant and prolonged drug level in plasma, minimizing inter- and intra-patient variability, and making it possible to interrupt or terminate treatment when necessary. The aim of the present investigation was to formulate and evaluate a monolithic drug-in-adhesive type patch containing Tenoxicam (TX using various polymers like Hydroxy Propyl Methyl Cellulose (HPMC, Ethyl Cellulose (EC and carbopol and plasticizers by solvent casting technique. The prepared transdermal patches were then evaluated for their physicochemical properties. The in-vitro release studies revealed that the release was sustained upto 24h and it follows zero order kinetics (r2 – 0.998. Finally, the patch formulation containing TX (G 7 selected through our in-vitro study. As a patient friendly and once a day dosing therapeutic system, the Transdermal patches incorporating TX could be promising in the pasture of Controlled drug delivery.

  18. Preparation of active 3D film patches via aligned fiber electrohydrodynamic (EHD) printing

    Science.gov (United States)

    Wang, Jun-Chuan; Zheng, Hongxia; Chang, Ming-Wei; Ahmad, Zeeshan; Li, Jing-Song

    2017-03-01

    The design, preparation and application of three-dimensional (3D) printed structures have gained appreciable interest in recent times, particularly for drug dosage development. In this study, the electrohydrodynamic (EHD) printing technique was developed to fabricate aligned-fiber antibiotic (tetracycline hydrochloride, TE-HCL) patches using polycaprolactone (PCL), polyvinyl pyrrolidone (PVP) and their composite system (PVP-PCL). Drug loaded 3D patches possessed perfectly aligned fibers giving rise to fibrous strut orientation, variable inter-strut pore size and controlled film width (via layering). The effect of operating parameters on fiber deposition and alignment were explored, and the impact of the film structure, composition and drug loading was evaluated. FTIR demonstrated successful TE-HCL encapsulation in aligned fibers. Patches prepared using PVP and TE-HCL displayed enhanced hydrophobicity. Tensile tests exhibited changes to mechanical properties arising from additive effects. Release of antibiotic from PCL-PVP dosage forms was shown over 5 days and was slower compared to pure PCL or PVP. The printed patch void size also influenced antibiotic release behavior. The EHDA printing technique provides an exciting opportunity to tailor dosage forms in a single-step with minimal excipients and operations. These developments are crucial to meet demands where dosage forms cannot be manufactured rapidly or when a personalized approach is required.

  19. Broadband Semielliptical Patch Antenna with Semicircular Ring Slot for WiMax Application

    Directory of Open Access Journals (Sweden)

    Brajraj Shrama

    2014-01-01

    Full Text Available This paper reports the design and analysis of a semielliptical patch antenna modified by cutting semicircular ring slot in patch geometry and obtained results are discussed. The reported antenna is designed on a multilayered substrate material having two glass epoxy FR-4 substrates separated by a thin foam substrate having thickness 1.0 mm. The size of ground plane is 75 mm×75 mm, whereas the patch dimension along major and minor axes is 23.0 mm and 14.0 mm, respectively. The two modes corresponding to resonance frequencies 3.39 GHz and 3.73 GHz are excited to provide wide impedance bandwidth 21.1% with respect to central frequency with stable radiation patterns. The antenna shows circular polarization with axial ratio bandwidth 5.5% and minimum axial ratio value 1.65 dBi. The radiation patterns of proposed antenna are normal to the surface of patch and are almost identical in shape as required for practical applications. The proposed antenna covers entire median band of WiMax communication systems ranges from 3.40 GHz to 3.6 GHz.

  20. Echo strength and density structure of Hawaiian mesopelagic boundary community patches

    Science.gov (United States)

    Benoit-Bird, Kelly J.; Au, Whitlow W. L.

    2003-10-01

    A broadband sonar system and digital camera with strobe lights were mounted on a vertically profiling frame with a depth sensor. The echo strengths and densities of animals within individual mesopelagic boundary community patches were investigated as a function of depth. Time and distance from shore were also investigated. Simultaneous surface echosounder surveys permitted comparison of density estimates from two techniques. Echo strength values suggest nearshore boundary community animals are primarily myctophid fishes, which was confirmed by preliminary photographic evidence. Echo strength varied significantly as a function of distance from the shoreline and time. These measures of echo strength are important for estimating density from a surface echosounder. Density estimates from these revised echo strengths compare well with those made with echo highlight counting, which is independent of echo strength. These density measures suggest that previous density estimates were too low but do not change the conclusions of these studies. Vertical microstructure in density was apparent but animal size and compositional structure was not evident within a patch. Patch edges were abrupt, with no differences in the density or echo strength from patch interiors. These edges were generally straight, with a sharp drop in density to the background density of zero. Estimates of animal size as a function of time provide information about the diel migration patterns of these mesopelagic animals.