WorldWideScience

Sample records for success brings approval

  1. Obesity management: what brings success?

    Science.gov (United States)

    Lagerros, Ylva Trolle; Rössner, Stephan

    2013-01-01

    The upward trend in obesity prevalence across regions and continents is a worldwide concern. Today a majority of the world's population live in a country where being overweight or obese causes more deaths than being underweight. Only a portion of those qualifying for treatment will get the health care they need. Still, a minor weight loss of 5-10% seems to be sufficient to provide a clinically significant health benefit in terms of risk factors for cardiovascular disease and diabetes. Diet, exercise and behavior modifications remain the current cornerstones of obesity treatment. Weight-loss drugs play a minor role. Drugs which were available and reasonably effective have been withdrawn because of side effects. The fact that the 'old' well known, but pretty unexciting tools remain the basic armamentarium causes understandable concern and disappointment among both patients and therapists. Hence, bariatric surgery has increasingly been recognized and developed, as it offers substantial weight loss and prolonged weight control. The present review highlights the conventional tools to counter obesity, lifestyle modification, pharmacotherapy and bariatric surgery, including some of the barriers to successful weight loss: (1) unrealistic expectations of success; (2) high attrition rates; (3) cultural norms of self-acceptance in terms of weight and beliefs of fat being healthy; (4) neighborhood attributes such as a lack of well-stocked supermarkets and rather the presence of convenience stores with low-quality foods; and (5) the perception of the neighborhood as less safe and with low walkability. Prevention is the obvious key. Cost-effective societal interventions such as a tax on unhealthy food and beverages, front-of-pack traffic light nutrition labeling and prohibition of advertising of junk food and beverages to children are also discussed.

  2. Bringing to Market Technological Innovation: What Distinguishes Success from Failure

    Directory of Open Access Journals (Sweden)

    Federico Frattini

    2012-09-01

    Full Text Available Commercialization is a critical step in technological innovation. Nevertheless, many scholars believe that it is often the least well-managed activity of the whole innovation process. The launch stage seems to be particularly critical in high-technology markets because of the volatility, interconnectedness and the proliferation of new technologies they experience. However, academic and practitioners’ literature has not, so far, developed a clear understanding of the factors that distinguish an effective commercialization from an unsuccessful one, especially in high-technology environments. This paper discusses the results of a research project that aimed to understand the ingredients for success in the commercialization of a technological innovation. The first stage of the research consisted of a comparative historical analysis of 18 innovations, which were commercialized in consumer high-tech markets in the last 30 years. The analysis advocates that an effective commercialization comprises three sub-strategies: Early adoption strategy, Adoption network configuration strategy and Mainstream adoption strategy, with each one characterized by a coherent set of commercialization dimensions. The relative importance of each sub-strategy in determining the innovation commercial success depends on the type of innovation that is commercialized, be it radical or incremental and discontinuous or continuous.

  3. Bringing your a-game: Educational gaming for student success.

    Science.gov (United States)

    Strickland, Haley P; Kaylor, Sara K

    2016-05-01

    The purpose of this article is to describe the theoretical basis for the integration of gaming in nursing education and discuss aspects related to the implementation of "The Race for Nursing Student Success" game. This game was designed for 112 junior-level baccalaureate nursing students enrolled in a fundamentals nursing course. Students were divided into groups of 5-8 and rotated through ten specific learning activities that took place in various locations throughout the nursing building. Student and faculty feedback indicated positive responses to this instructional strategy and also promoted a learner-centered teaching environment. This learning activity supports the use of educational gaming as a means to develop learner-centered environments that provide experiential experiences, enhance learning, and stimulate interest, and motivation for students to learn. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. New technology planning and approval: critical factors for success.

    Science.gov (United States)

    Haselkorn, Ateret; Rosenstein, Alan H; Rao, Anil K; Van Zuiden, Michele; Coye, Molly J

    2007-01-01

    The steady evolution of technology, with the associated increased costs, is a major factor affecting health care delivery. In the face of limited capital resources, it is important for hospitals to integrate technology management with the strategic plan, mission, and resource availability of the organization. Experiences in technology management have shown that having a well-organized, consistent approach to technology planning, assessment, committee membership, approval, evaluation, implementation, and monitoring are key factors necessary to ensure a successful program. We examined the results of a survey that assessed the structure, processes, and cultural support behind hospital committees for new technology planning and approval.

  5. Bringing your tools to CyVerse Discovery Environment using Docker [version 2; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Upendra Kumar Devisetty

    2016-11-01

    Full Text Available Docker has become a very popular container-based virtualization platform for software distribution that has revolutionized the way in which scientific software and software dependencies (software stacks can be packaged, distributed, and deployed. Docker makes the complex and time-consuming installation procedures needed for scientific software a one-time process. Because it enables platform-independent installation, versioning of software environments, and easy redeployment and reproducibility, Docker is an ideal candidate for the deployment of identical software stacks on different compute environments such as XSEDE and Amazon AWS. Cyverse's Discovery Environment also uses Docker for integrating its powerful, community-recommended software tools into CyVerse's production environment for public use. This paper will help users bring their tools into CyVerse DE which will not only allows users to integrate their tools with relative ease compared to the earlier method of tool deployment in DE but also help users to share their apps with collaborators and also release them for public use.

  6. Bringing your tools to CyVerse Discovery Environment using Docker [version 3; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Upendra Kumar Devisetty

    2016-12-01

    Full Text Available Docker has become a very popular container-based virtualization platform for software distribution that has revolutionized the way in which scientific software and software dependencies (software stacks can be packaged, distributed, and deployed. Docker makes the complex and time-consuming installation procedures needed for scientific software a one-time process. Because it enables platform-independent installation, versioning of software environments, and easy redeployment and reproducibility, Docker is an ideal candidate for the deployment of identical software stacks on different compute environments such as XSEDE and Amazon AWS. Cyverse's Discovery Environment also uses Docker for integrating its powerful, community-recommended software tools into CyVerse's production environment for public use. This paper will help users bring their tools into CyVerse DE which will not only allows users to integrate their tools with relative ease compared to the earlier method of tool deployment in DE but also help users to share their apps with collaborators and also release them for public use.

  7. Bringing your tools to CyVerse Discovery Environment using Docker [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Upendra Kumar Devisetty

    2016-06-01

    Full Text Available Docker has become a very popular container-based virtualization platform for software distribution that has revolutionized the way in which scientific software and software dependencies (software stacks can be packaged, distributed, and deployed. Docker makes the complex and time-consuming installation procedures needed for scientific software a one-time process. Because it enables platform-independent installation, versioning of software environments, and easy redeployment and reproducibility, Docker is an ideal candidate for the deployment of identical software stacks on different compute environments such as XSEDE and Amazon AWS. CyVerse’s Discovery Environment also uses Docker for integrating its powerful, community-recommended software tools into CyVerse’s production environment for public use. This paper will help users bring their tools into CyVerse Discovery Environment (DE which will not only allows users to integrate their tools with relative ease compared to the earlier method of tool deployment in DE but will also help users to share their apps with collaborators and release them for public use.

  8. Bringing the Microcomputer into the Junior High: A Success Story from Florida.

    Science.gov (United States)

    Miller, Benjamin S.

    1982-01-01

    Describes the introduction of an Apple II microcomputer into Miami Lakes (Florida) Junior High School and its success in generating enthusiasm among teachers, students, parents, and the community. (Author/RW)

  9. How To Run a Successful Community Newspaper and Bring It into the 21st Century.

    Science.gov (United States)

    Becker, Jay

    1999-01-01

    Provides advice and guidelines for running a successful community newspaper. Sixteen criteria of a good local paper include reporting on all civic activities, keeping tabs on where tax dollars go, getting out to listen to community members, encouraging community dialogue, celebrating achievements, explaining the meaning of local happenings,…

  10. Management Educators Can Bring Awareness to the Need to Plan for Succession

    Science.gov (United States)

    Lampton, Jolene A.

    2011-01-01

    Management educators can pick up on consultants' trends as related to succession planning in the real world. An opportunity exists for management educators to clarify some subjects in management curricula and solidify issues that are happening with groups of practitioners. Younger practitioners may need to be taught and supported differently than…

  11. Pharmaceutical R&D performance by firm size: approval success rates and economic returns.

    Science.gov (United States)

    DiMasi, Joseph A

    2014-01-01

    The R&D productivity of pharmaceutical firms has become an increasingly significant concern of industry, regulators, and policymakers. To address an important aspect of R&D performance, public and private data sources were used to estimate clinical phase transition and clinical approval probabilities for the pipelines of the 50 largest pharmaceutical firms (by sales) by 3 firms size groups (top 10 firms, top 11-20 firms, and top 21-50 firms). For self-originated compounds, the clinical approval success rates were 14.3%, 16.4%, and 18.4% for top 10 firms, top 11-20 firms, and top 21-50 firms, respectively. The results showing higher success rates for smaller firms were largely driven by outcomes for the small-molecule drugs. Adjustments for the relatively small differences in therapeutic class distributions across the firm size groups showed that the success rate for small-molecule self-originated drugs was 6% below average for top 10 firms and 17% above average for top 21-50 firms. Although success rates for small firms were higher, this advantage was offset to some degree by lower returns on approved drugs, suggesting different strategic objectives with regard to risk and reward by firm size.

  12. The analysis of the market success of FDA approvals by probing top 100 bestselling drugs

    Science.gov (United States)

    Polanski, Jaroslaw; Bogocz, Jacek; Tkocz, Aleksandra

    2016-05-01

    Target-oriented drug discovery is the main research paradigm of contemporary drug discovery. In target-oriented approaches, we attempt to maximize in vitro drug potency by finding the optimal fit to the target. This can result in a higher molecular complexity, in particular, the higher molecular weight (MW) of the drugs. However, a comparison of the successful developments of pharmaceuticals with the general trends that can be observed in medicinal chemistry resulted in the conclusion that the so-called molecular obesity is an important reason for the attrition rate of drugs. When analyzing the list of top 100 drug bestsellers versus all of the FDA approvals, we discovered that on average lower-complexity (MW, ADMET score) drugs are winners of the top 100 list in terms of numbers but that, especially, up to some optimal MW value, a higher molecular complexity can pay off with higher incomes. This indicates that slim drugs are doing better but that fat drugs are bigger fishes to catch.

  13. All roads bring to Rome: a different way for predicting success in the therapy of obesity through psychological features.

    Science.gov (United States)

    Rotella, Francesco; Lazzeretti, Lisa; Barbaro, Valeria; Castellini, Giovanni; Bigiarini, Michela; Cresci, Barbara; Ricca, Valdo; Rotella, Carlo Maria; Mannucci, Edoardo

    2014-12-01

    Obesity treatment based on lifestyle modifications is characterized by a high proportion of treatment failures. The study of predictors of success could be useful for a better definition of therapeutic needs in individual patients. Few studies have attempted a comprehensive assessment of psychological factors related with treatment response. Aim of the study is the identification of psychological and psychopathological features associated with a good treatment response in patients referring for obesity. This prospective observational study was conducted on a consecutive series of 270 obese patients and a six-month follow-up was performed. At enrollment, a complete medical history was collected and, psychopathology and psychological features were assessed with: General psychopathology: Symptom Checklist 90-revised, Eating Disorder Examination-Questionnaire, Obesity Related well-being and Treatment, Motivation and Readiness test. Among the 231 patients evaluated at follow-up, the mean weight loss was 3.2% of initial body weight and 68 patients (29.4%) reached the pre-defined therapeutic target of 5% weight loss. Higher psychopathology was associated with a worse outcome in women only; whereas motivation was higher in patients achieving therapeutic targets among men, but not in women. Mean weight loss obtained with lifestyle interventions is confirmed to be rather small and a more accurate selection of patients to be enrolled in lifestyle intervention programs is needed. The present study provides some intriguing information on predictors of weight loss, which could be useful for the identification of patients with a higher chance of succeeding with lifestyle programs for the treatment of obesity.

  14. Integrating succession and community assembly perspectives [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Cynthia Chang

    2016-09-01

    Full Text Available Succession and community assembly research overlap in many respects, such as through their focus on how ecological processes like dispersal, environmental filters, and biotic interactions influence community structure. Indeed, many recent advances have been made by successional studies that draw on modern analytical techniques introduced by contemporary community assembly studies. However, community assembly studies generally lack a temporal perspective, both on how the forces structuring communities might change over time and on how historical contingency (e.g. priority effects and legacy effects and complex transitions (e.g. threshold effects might alter community trajectories. We believe a full understanding of the complex interacting processes that shape community dynamics across large temporal scales can best be achieved by combining concepts, tools, and study systems into an integrated conceptual framework that draws upon both succession and community assembly theory.

  15. Bringing science to business

    Science.gov (United States)

    Lemetti, Paul

    2005-06-01

    Bringing science to business seems rather straight forward. Technology is constantly moving forward and new inventions are being brought into the market place. Science parks and technology parks have sprung out all around the globe competing against each other and trying to keep their own doors open by bringing in new business, thereby creating much needed income to keep their operations moving forward. However, only a small handful ofthese centers around the world can truly be considered successful. It is the relationship between the scientists, start-up business, local universities, local government, and invited bigger business that allows the parks to succeed. The individual scientist wishing to enter into business or just hoping to get his invention into the pool of potential ideas; which might end up in the hands of an entrepreneur or an established company, is not always that simple. Universal success principles must be embraced to ensure success. One must believe in oneself and to strive for excellence. One must be able to see the other persons viewpoint and adapt and change his behavior in order to succeed. One must learn to create trust as well as learn to trust. Furthermore, one must learn to focus on the why of the process and not on the how. A market must be identified and benefits of local area must be sold to potential investor or business partners. A local success has in part to do with local cooperation.

  16. Bringing Your Baby Home

    Science.gov (United States)

    ... for Educators Search English Español Bringing Your Baby Home KidsHealth / For Parents / Bringing Your Baby Home What's ... recall your baby's seemingly endless crying episodes. The Home Front Introducing your baby to others at home ...

  17. Advanced Therapy Medicinal Products: How to Bring Cell-Based Medicinal Products Successfully to the Market - Report from the CAT-DGTI-GSCN Workshop at the DGTI Annual Meeting 2014.

    Science.gov (United States)

    Celis, Patrick; Ferry, Nicolas; Hystad, Marit; Schüßler-Lenz, Martina; Doevendans, Pieter A; Flory, Egbert; Beuneu, Claire; Reischl, Ilona; Salmikangas, Paula

    2015-05-01

    On September 11, 2014, a workshop entitled 'Advanced Therapy Medicinal Products: How to Bring Cell-Based Medicinal Product Successfully to the Market' was held at the 47th annual meeting of the German Society for Transfusion Medicine and Immunohematology (DGTI), co-organised by the European Medicines Agency (EMA) and the DGTI in collaboration with the German Stem Cell Network (GSCN). The workshop brought together over 160 participants from academia, hospitals, small- or medium-sized enterprise developers and regulators. At the workshop, speakers from EMA, the Committee for Advanced Therapies (CAT), industry and academia addressed the regulatory aspects of development and authorisation of advanced therapy medicinal products (ATMPs), classification of ATMPs and considerations on cell-based therapies for cardiac repair. The open forum discussion session allowed for a direct interaction between ATMP developers and the speakers from EMA and CAT.

  18. Advanced Therapy Medicinal Products: How to Bring Cell-Based Medicinal Products Successfully to the Market – Report from the CAT-DGTI-GSCN Workshop at the DGTI Annual Meeting 2014

    Science.gov (United States)

    Celis, Patrick; Ferry, Nicolas; Hystad, Marit; Schüßler-Lenz, Martina; Doevendans, Pieter A.; Flory, Egbert; Beuneu, Claire; Reischl, Ilona; Salmikangas, Paula

    2015-01-01

    On September 11, 2014, a workshop entitled ‘Advanced Therapy Medicinal Products: How to Bring Cell-Based Medicinal Product Successfully to the Market’ was held at the 47th annual meeting of the German Society for Transfusion Medicine and Immunohematology (DGTI), co-organised by the European Medicines Agency (EMA) and the DGTI in collaboration with the German Stem Cell Network (GSCN). The workshop brought together over 160 participants from academia, hospitals, small- or medium-sized enterprise developers and regulators. At the workshop, speakers from EMA, the Committee for Advanced Therapies (CAT), industry and academia addressed the regulatory aspects of development and authorisation of advanced therapy medicinal products (ATMPs), classification of ATMPs and considerations on cell-based therapies for cardiac repair. The open forum discussion session allowed for a direct interaction between ATMP developers and the speakers from EMA and CAT. PMID:26195933

  19. Reproductive success is predicted by social dynamics and kinship in managed animal populations [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Saul J. Newman

    2016-05-01

    Full Text Available Kin and group interactions are important determinants of reproductive success in many species. Their optimization could, therefore, potentially improve the productivity and breeding success of managed populations used for agricultural and conservation purposes. Here we demonstrate this potential using a novel approach to measure and predict the effect of kin and group dynamics on reproductive output in a well-known species, the meerkat Suricata suricatta. Variation in social dynamics predicts 30% of the individual variation in reproductive success of this species in managed populations, and accurately forecasts reproductive output at least two years into the future. Optimization of social dynamics in captive meerkat populations doubles their projected reproductive output. These results demonstrate the utility of a quantitative approach to breeding programs informed by social and kinship dynamics. They suggest that this approach has great potential for improvements in the management of social endangered and agricultural species.

  20. Bringing physics to life

    Science.gov (United States)

    2000-01-01

    `I'm doing a physics that is pulling me towards it.' `I like the course being more up to date.' `You learn the physics but you also think ``well I actually see a point in knowing this physics''.' `This course presents physics in a more interesting way as it focuses on practical activity and applications of physics.' `The industrial visit gives students the opportunity to look for science in action.' These are just some of the comments from students and teachers piloting the new Salters Horners Advanced Physics course (SHAP). Contexts and applications drive the course, providing interest and motivation for students and alerting them to some of the many career areas that involve physics. For example, the operation of a CD player leads to a study of waves and superposition; archaeological surveying and analysis brings in d.c. circuitry and x-ray diffraction; consideration of safety in rail transport involves learning about mechanics and electromagnetism. The course is produced by a team directed from the University of York and funded by a consortium of industrial and charitable sponsors. It is examined by Edexcel and support materials are published by Heinemann. The pilot, involving some 50 centres, began in September 1998 with the new subject core and the AS qualification intermediate between GCSE and the full A-level standard. The course has been fully approved by QCA, and from September 2000 it will be open to all. For comprehensive information about SHAP, visit the project's website: www.york.ac.uk/org/seg/salters/physics . Pilot materials for students, teachers and technicians are available from Heinemann. They will be re-edited and published in full colour for September 2000. Members of the team will attend the annual ASE meeting in Leeds this month; there will be a talk and a hands-on workshop where student activities can be sampled. Materials will be on view at the University of York stand. In addition, Edexcel and the York team are running a series of

  1. Bringing Things Together

    DEFF Research Database (Denmark)

    Gundelach, Peter

    2017-01-01

    as facts, i.e. establish a scientific authoritative truth. In a case study from Denmark, the paper shows how the first survey - a study of seamstresses - was carried out by bringing several cognitive and organizational elements together: a network of researchers, a method for sampling, the construction...

  2. Marketing CE approved off-the-shelf FC-operated power backup units for the telecom industry at competitive prices : a continuing success story

    Energy Technology Data Exchange (ETDEWEB)

    Mortensen, P. [Dantherm Power, Skive (Denmark)

    2009-07-01

    Dantherm Power receives a steady supply of fuel cell stacks packed on pallets at its factory in Denmark. Once unpacked, they go to an assembly line to be integrated into power modules designed for telecom- and IT network-base-stations around the world. The CE approved units are designed and tested to meet current telecom standards. Customers can purchase the off-the-shelf units at competitive prices. Dantherm Power has brought fuel-cell technology beyond the research and development stage. Since 2005, the company has sold backup units providing uninterruptible power supply (UPS) to the telecom industry on standard commercial terms. Their fuel cell-based-solutions have proven to be successful. The company began in 2003 as a research and development project within Dantherm Air Handling A/S. Development was driven by the idea that a UPS-system based on hydrogen and fuel-cell-technology may be better solution than traditional battery and diesel driven backup for many of the company's existing clients.

  3. The PAANEEAC programme: bringing EIA professionals together

    OpenAIRE

    Nooteboom, Sibout; Boven, G.; Post, Reinoud

    2015-01-01

    markdownabstract__Abstract__ National EIA systems include many actors: EIA agencies, project proponents, sectoral authorities, environmental and social NGOs, consultants, academics, lawyers, politicians and even journalists. Their views and actions largely determine whether EIA systems are successfully strengthened. The PAANEEAC programme assisted national associations of EIA professionals in Central Africa to bring all these actors together, to become platforms for exchange, and to undertake...

  4. FORMED: Bringing Formal Methods to the Engineering Desktop

    Science.gov (United States)

    2016-02-01

    FORMED: BRINGING FORMAL METHODS TO THE ENGINEERING DESKTOP BAE SYSTEMS FEBRUARY 2016 FINAL TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE...This report is published in the interest of scientific and technical information exchange, and its publication does not constitute the Government’s...BRINGING FORMAL METHODS TO THE ENGINEERING DESKTOP 5a. CONTRACT NUMBER FA8750-14-C-0024 5b. GRANT NUMBER N/A 5c. PROGRAM ELEMENT NUMBER 63781D

  5. Bringing "indigenous" ownership back

    DEFF Research Database (Denmark)

    Kragelund, Peter

    2012-01-01

    policies thrive again, this time disguised in terms such as ‘empowerment’, but just as politicised as in the 1970s. Zambia is at the heart of this development. In the light of liberalisation, booming commodity prices and the increasing importance of Chinese investors, this article seeks to further our...... understanding of how processes of exclusion interact with domestic politics in Zambia. It argues that the Citizens Economic Empowerment Commission, a new institution to bring ownership back to Zambians, builds on a long tradition of nationalist policies in Zambia, while its actual work is strictly related...... to the critique of the growing foreign dominance over the economy, and in particular of the upsurge in Chinese investments....

  6. Bringing up Gender: Academic Abjection?

    Science.gov (United States)

    Henderson, Emily F.

    2014-01-01

    The principal questions raised in this article are: what does it mean to bring up the topic of gender in a space where it is not known, and how can this moment of bringing up gender--or not bringing it up--be conceptualised? The article departs from the thoughts and questions that were provoked by an interview conducted with a Gender Studies…

  7. Bring learning into action

    Directory of Open Access Journals (Sweden)

    Annemieke van den Berg

    2018-05-01

    Full Text Available Context: This critical reflection is about the positive effects for educational and research settings of participation in a two-day programme entitled ‘Using participatory action research and appreciative inquiry to research healthcare practice’. Aims: To reflect on the journey of positive developments in research and education that started with participation in this programme. Using Caring Conversations (Dewar, 2011 as a reflective framework of questions, this article discusses the journey in order to encourage others to consider the approach of appreciative inquiry to bring to life the concept of co-creation in research and education. Conclusions and implications for practice: Participation in this programme has led to the implementation of a variety of actions in educational and research settings. Central to all these actions is an appreciative approach to co-creation as a counterpart to today’s prevailing problem-based viewpoint. A possible factor behind these developments was the power of vulnerability experienced during the programme, a shared process of transformational learning. Implications for practice: This critical reflection: Provides an invitation to shift from a problem-based focus to a positive revolution Provides an appreciative reflective story about the power of vulnerability as an inspiration for others to move out of their comfort zone and seek to discover their own exceptionality Supports a shift from a facilitator-led to a co-creation approach in doing research and teaching with older adults

  8. Bringing Gravity to Space

    Science.gov (United States)

    Norsk, P.; Shelhamer, M.

    2016-01-01

    This panel will present NASA's plans for ongoing and future research to define the requirements for Artificial Gravity (AG) as a countermeasure against the negative health effects of long-duration weightlessness. AG could mitigate the gravity-sensitive effects of spaceflight across a host of physiological systems. Bringing gravity to space could mitigate the sensorimotor and neuro-vestibular disturbances induced by G-transitions upon reaching a planetary body, and the cardiovascular deconditioning and musculoskeletal weakness induced by weightlessness. Of particular interest for AG during deep-space missions is mitigation of the Visual Impairment Intracranial Pressure (VIIP) syndrome that the majority of astronauts exhibit in space to varying degrees, and which presumably is associated with weightlessness-induced fluid shift from lower to upper body segments. AG could be very effective for reversing the fluid shift and thus help prevent VIIP. The first presentation by Dr. Charles will summarize some of the ground-based and (very little) space-based research that has been conducted on AG by the various space programs. Dr. Paloski will address the use of AG during deep-space exploration-class missions and describe the different AG scenarios such as intra-vehicular, part-of-vehicle, or whole-vehicle centrifugations. Dr. Clement will discuss currently planned NASA research as well as how to coordinate future activities among NASA's international partners. Dr. Barr will describe some possible future plans for using space- and ground-based partial-G analogs to define the relationship between physiological responses and G levels between 0 and 1. Finally, Dr. Stenger will summarize how the human cardiovascular system could benefit from intermittent short-radius centrifugations during long-duration missions.

  9. Bring back the Glory!

    Directory of Open Access Journals (Sweden)

    James Q. Whitman

    2004-01-01

    Full Text Available This paper, drafted in response to Dr. Kiesow’s question, »Wozu Rechtsgeschichte?«, begins with a backward glance at the nineteenth century, when legal history played a leading role in the intellectual life of the western world. Since those great days, when legal history attracted figures like Karl Marx and Max Weber, the field has fallen on hard times. This is in large part the inevitable consequence of the declining prestige of law itself, which no longer seems to matter in the way that it did in the nineteenth century. Nevertheless, the paper pleads for something of a Return of Grand Theory in legal history. It is true that we can never bring back the glory years. But we can be figures of importance in the public debates of our time if we remain mindful of what it is that gives law itself its enduring social importance. Law reflects, in an unsystematic but telling way, some of the basic value commitments of society-commitments such as the contemporary American commitment to the free market, or the contemporary European commitment to »human dignity«. Law also reflects stylized histories of a given society’s past-histories like that of the American triumph over race slavery, or the European triumph over Nazism. These value commitments and stylized histories are the natural territory of legal historians, who can best claim a role for themselves in public debate if they think of themselves as historians of values, rather than as historians of social realities.

  10. Bringing up beams

    CERN Multimedia

    Katarina Anthony

    2013-01-01

    Last month, commissioning began on CERN’s newest linear accelerator: Linac4. As the replacement machine for Linac2, Linac4 will take a negative hydrogen ion beam to a staggering 160 MeV. We check in to see how the Linac4 team is preparing its machine for its new role as the first link in the accelerator chain.   The Linac4 3 MeV beam line, with the ion source in the back, the RFQ in the middle and the chopping line in the front. On 14 November, members of the Linac4 collaboration and the CERN Operations Group were brought together for their first “real day” in the Linac4 Control Room. Together, they successfully accelerated their first hydrogen ion beam to 3 MeV. It was an exciting moment for everyone involved and marked the start of one of the most critical commissioning phases for the new accelerator. At the start of the Linac4 beam line sits the CERN-made Radio Frequency Quadrupole (RFQ). This vital piece of machinery takes the beam from 45 keV to 3 MeV in ju...

  11. Bringing Geoethics into Society

    Science.gov (United States)

    Di Capua, Giuseppe; Bobrowsky, Peter; Kieffer, Susan; Peppoloni, Silvia; Tinti, Stefano

    2015-04-01

    The responsibility and role of the scientific community in the proper exploitation of natural resources, in the defense against natural hazards and in building geoeducational strategies for the population are key themes of Geoethics. But, what is the awareness among Geoscientists about the importance of an ethical debate within Earth Sciences? With the goal to increase this awareness, in 2012 the IAPG - International Association for Promoting Geoethics was founded (http://www.iapg.geoethics.org). The IAPG aims to join forces of geoscientists all over the world, by creating an international, multidisciplinary and scientific platform for discussing on ethical problems and dilemmas in Earth Sciences, for promoting Geoethics themes through scientific publications and conferences, for strengthening the research base on Geoethics, for focusing on case-studies to be taken as models for the development of effective and operative strategies. The IAPG has obtained the status of affiliated organization by the International Union of Geological Sciences (IUGS), it is among the collaborative organizations of the IUGS - Task Group on Global Geoscience Professionalism (TGGGP), and it has been recognized as an International Associate Organization of the American Geosciences Institute (AGI). The IAPG network is growing fast and currently it is going to reach 500 members in more than 75 countries in 5 continents. The IAPG is working to offer its contribution in building a framework of values for a new model of development, more respectful towards the Geosphere. After 2 years of successful results and numerous ongoing activities, IAPG appears to be on the right way in promoting new ideas to research and practice geosciences. This work aims to give an overview on the IAPG activities, to illustrate the IAPG impact on public through web-statistics, to present publications, events and other initiatives on Geoethics carried out by its members.

  12. Bring Your Own Device or Bring Your Own Distraction

    Science.gov (United States)

    Laxman, Kumar; Holt, Craig

    2017-01-01

    The purpose of this exploratory case study was to investigate the utilisation of Bring Your Own Device (BYOD) technologies in the classroom to determine if students and teachers perceive that the use of a digital device increased a learner's access to learning opportunities within the classroom, and, if the use of digital devices increased their…

  13. Bringing to Market Technological Innovation: What Distinguishes Success from Failure

    OpenAIRE

    Frattini, Federico; Massis, Alfredo De; Chiesa, Vittorio; Cassia, Lucio; Campopiano, Giovanna

    2012-01-01

    Commercialization is a critical step in technological innovation. Nevertheless, many scholars believe that it is often the least well-managed activity of the whole innovation process. The launch stage seems to be particularly critical in high-technology markets because of the volatility, interconnectedness and the proliferation of new technologies they experience. However, academic and practitioners' literature has not, so far, developed a clear understanding of the factors that distinguish a...

  14. The novel POSEIDON stratification of ‘Low prognosis patients in Assisted Reproductive Technology’ and its proposed marker of successful outcome [version 1; referees: 2 approved, 1 approved with reservations

    Directory of Open Access Journals (Sweden)

    Peter Humaidan

    2016-12-01

    Full Text Available In reproductive medicine little progress has been achieved regarding the clinical management of patients with a reduced ovarian reserve or poor ovarian response (POR to stimulation with exogenous gonadotropins -a frustrating experience for clinicians as well as patients. Despite the efforts to optimize the definition of this subgroup of patients, the existing POR criteria unfortunately comprise a heterogeneous population and, importantly, do not offer any recommendations for clinical handling. Recently, the POSEIDON group (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number proposed a new stratification of assisted reproductive technology (ART in patients with a reduced ovarian reserve or unexpected inappropriate ovarian response to exogenous gonadotropins. In brief, four subgroups have been suggested based on quantitative and qualitative parameters, namely, i. Age and the expected aneuploidy rate; ii. Ovarian biomarkers (i.e. antral follicle count [AFC] and anti-Müllerian hormone [AMH], and iii. Ovarian response - provided a previous stimulation cycle was performed. The new classification introduces a more nuanced picture of the “low prognosis patient” in ART, using clinically relevant criteria to guide the physician to most optimally manage this group of patients. The POSEIDON group also introduced a new measure for successful ART treatment, namely, the ability to retrieve the number of oocytes needed for the specific patient to obtain at least one euploid embryo for transfer. This feature represents a pragmatic endpoint to clinicians and enables the development of prediction models aiming to reduce the time-to-pregnancy (TTP. Consequently, the POSEIDON stratification should not be applied for retrospective analyses having live birth rate (LBR as endpoint. Such an approach would fail as the attribution of patients to each Poseidon group is related to specific requirements and could only be made prospectively. On the

  15. Bringing the mountain to Mohammed

    International Nuclear Information System (INIS)

    Hibbs, S.M.; Bell, H.H.; Bowman, F.M.; Hitchin, C.; Jackson, M.

    1987-01-01

    New free electron laser (FEL) technology at Lawrence Livermore National Laboratory (LLNL) promises electron-cyclotron plasma heating at power levels, cost efficiency, and tunable frequency range far beyond the capabilities of existing technology. LLNL has the high-current induction linear accelerators needed to drive such an FEL. Thus, the first stage of the Microwave Tokamak Experiment (MTX), designed to test this new technology, was to bring the Alcator-C tokamak across the United States from the Massachusetts Institute of Technology (MIT) to LLNL in California. The authors discuss why the tokamak was moved across the country and described the move

  16. Bringing Secrecy into the Open

    DEFF Research Database (Denmark)

    Costas, Jana; Grey, Christopher

    2014-01-01

    This paper brings into focus the concept of organizational secrecy, defined as the ongoing formal and informal social processes of intentional concealment of information from actors by actors in organizations. It is argued that existing literature on the topic is fragmented and predominantly...... focused on informational rather than social aspects of secrecy. The paper distinguishes between formal and informal secrecy and theorizes the social processes of these in terms of identity and control. It is proposed that organizational secrecy be added to the analytical repertoire of organization studies....

  17. Bringing nursing to the public.

    Science.gov (United States)

    Kazis, Cornelia; Schwendimann, René

    2009-11-01

    For the past 5 years, an unusual program has been evolving in the University of Basel's Institute of Nursing Science master's program in Basel, Switzerland. A special course designed to help nurses master public communication skills requires students to play the roles of journalist, exhibition curator, conference organizer, radio reporter, and news producer. Two faculty members, an experienced radio and newspaper journalist and a nurse scientist, teach and support the students. By developing their competence in media relations, participants prepare themselves to tackle the course's long-term goal of bringing the nursing profession into the public eye. Copyright 2009, SLACK Incorporated.

  18. BYOD: Bring your own disaster

    CERN Multimedia

    Computer Security Team

    2013-01-01

    Have you ever heard of “BYOD”? No, it is not a pop band. Try again. It is short for “Bring Your Own Device” (the French use “AVEC” -  “Apporter Votre Equipement personnel de Communication”) and describes an option long since offered at CERN: the possibility to bring along your personal laptop, smartphone or PDA, use it on CERN premises and connect it to the CERN office network. But hold on. As practical as it is, there is also a dark side.   The primary advantage, of course, is having a digital work environment tuned to your needs and preferences. It allows you to continue working at home. Similarly, you always have your music, address books and bookmarks with you. However, as valuable as this is, it is also a responsibility. Laptop theft is happening - outside CERN but also on site. In France, 30% of stolen laptops were stolen out of cars or homes, and 10% during travel. At CERN, on average one ...

  19. Bring Your Own Device: Parental Guidance (PG) Suggested

    Science.gov (United States)

    Kiger, Derick; Herro, Dani

    2015-01-01

    Educators are incorporating students' mobile devices into the schooling experience via Bring Your Own Device (BYOD) initiatives. This is advantageous for many reasons, most notably, improving access to Internet resources and digital tools in support of teaching and learning. Obtaining parental support is key to BYOD success. Therefore, this study…

  20. Convention on Early Notification of a Nuclear Accident and Convention on Assistance in the Case of a Nuclear Accident or Radiological Emergency. Status lists as of 30 September 2002. Signature, ratification, acceptance, approval, accession or succession. Declarations/reservations made upon expressing consent to be bound and objections thereto. Declarations/reservations made upon signature

    International Nuclear Information System (INIS)

    2002-01-01

    This document includes the information given in document INFCIRC/335/Add.10 and INFCIRC/336/Add. 11. It accordingly supersedes that document. It contains signatures, ratification, acceptance, approval, accession or successions, as well as declarations/reservations made upon signature by the countries and-or organizations with have accepted it

  1. Convention on early notification of a nuclear accident and convention on assistance in the case of a nuclear accident or radiological emergency. Status lists as of 12 September 2000. Signature, ratification, acceptance, approval, accession or succession. Declarations/reservations made upon expressing consent to be bound and objections thereto. Declarations/reservations made upon signature

    International Nuclear Information System (INIS)

    2000-01-01

    This document includes the information given in document INFCIRC/335/Add.9 and INFCIRC/336/Add. 10. It accordingly supersedes that document. It contains signatures, ratification, acceptance, approval, accession or successions, as well as declarations/reservations made upon signature by the countries and-or organizations with have accepted it

  2. Convention on the physical protection of nuclear material. Status list as of 12 September 2000. Signature, ratification, acceptance, approval, accession or succession. Declarations/reservations made upon expressing consent to be bound and objections thereto. Declarations/reservations made upon signature

    International Nuclear Information System (INIS)

    2000-01-01

    This document contains signatures, ratifications, acceptance, approval, accession or succession of the Convention on the physical protection of nuclear material as well as declarations/reservations made upon expressing consent to be bound and objections thereto and declarations made upon signature

  3. ABWR certification work brings US licensing stability nearer

    International Nuclear Information System (INIS)

    Wilkins, D.R.; Quirk, J.F.

    1991-01-01

    The Advanced Boiling Water Reactor (ABWR) is now approaching Final Design Approval by the US Nuclear Regulatory Commission (NRC) and will then proceed on to the certification phase of the NRC's new standard plant licensing process. Successful completion of this will usher in a new era of standardization and reactor licensing stability in the US. (author)

  4. Five Ways to Hack and Cheat with Bring-Your-Own-Device Electronic Examinations

    Science.gov (United States)

    Dawson, Phillip

    2016-01-01

    Bring-your-own-device electronic examinations (BYOD e-exams) are a relatively new type of assessment where students sit an in-person exam under invigilated conditions with their own laptop. Special software restricts student access to prohibited computer functions and files, and provides access to any resources or software the examiner approves.…

  5. Marshland study brings fruitful results

    Energy Technology Data Exchange (ETDEWEB)

    1978-03-01

    There are approximately 110,000 square kilometers of marshland in China containing peat and other valuable resources. The results of a marshland study have been presented as a chapter in a book titled Physical Geography of China. In 1970, the Kirin Normal University established an experimental plant for the utilization of peat. Four kinds of peat fertilizers produced by this plant have been used with good results at 20 communes in Kirin Province. Four kinds of construction materials (peat board, peat tiles, peat insulation bricks and peat insulation tubes) were also successfully made. A certain type of peat can be used as fuel to heat malt in the process of whiskey making. New applications of peat have been found in medicine, water purification, and in the manufacturing of electrodes for condensers.

  6. Bringing Planctomycetes into pure culture

    Directory of Open Access Journals (Sweden)

    Olga Maria Lage

    2012-12-01

    Full Text Available Planctomycetes have been known since the description of Planctomyces bekefii by Gimesi at the beginning of the twentieth century (1924, although the first axenic cultures were only obtained in the 1970s. Since then, eleven genera with fourteen species have been validly named and five candidatus genera belonging to the anaerobic ammonium oxidation, anammox bacteria have also been discovered. However, Planctomycetes diversity is much broader than these numbers indicate, as shown by environmental molecular studies. In recent years the authors have attempted to isolate and cultivate additional strains of Planctomycetes. This paper provides a summary of the isolation work that was carried out to obtain in pure culture Planctomycetes from several environmental sources. The following strains and planctomycetes have been successfully isolated: two freshwater strains from the sediments of an aquarium, which were described as a new genus and species, Aquisphaera giovannonii; several Rhodopirellula strains from the sediments of a water treatment recycling tank of a marine fish farm; and more than 140 planctomycetes from the biofilm community of macroalgae. This collection comprises several novel taxa that are being characterized and described. Improvements in the isolation methodology were made in order to optimize and enlarge the number of Planctomycetes isolated from the macroalgae. The existence of an intimate and an important relationship between planctomycetes and macroalgae reported before by molecular studies is therefore supported by culture dependent methods.

  7. Exercise Brings Bone Benefits that Last

    Science.gov (United States)

    ... Subscribe May 2014 Print this issue Health Capsule Exercise Brings Bone Benefits that Last En español Send ... lose bone. Studies of animals have shown that exercise during periods of rapid growth can lead to ...

  8. Integration of new technology into clinical practice after FDA approval.

    Science.gov (United States)

    Govil, Ashul; Hao, Steven C

    2016-10-01

    Development of new medical technology is a crucial part of the advancement of medicine and our ability to better treat patients and their diseases. This process of development is long and arduous and requires a significant investment of human, financial and material capital. However, technology development can be rewarded richly by its impact on patient outcomes and successful sale of the product. One of the major regulatory hurdles to technology development is the Food and Drug Administration (FDA) approval process, which is necessary before a technology can be marketed and sold in the USA. Many businesses, medical providers and consumers believe that the FDA approval process is the only hurdle prior to use of the technology in day-to-day care. In order for the technology to be adopted into clinical use, reimbursement for both the device as well as the associated work performed by physicians and medical staff must be in place. Work and coverage decisions require Current Procedural Terminology (CPT) code development and Relative Value Scale Update Committee (RUC) valuation determination. Understanding these processes is crucial to the timely availability of new technology to patients and providers. Continued and better partnerships between physicians, industry, regulatory bodies and payers will facilitate bringing technology to market sooner and ensure appropriate utilization.

  9. Bringing a Finnish Company to the Russian E-Market

    OpenAIRE

    Veselova, Victoria

    2012-01-01

    The main objective of the project was to enable a small business case company that is operating in the town of Lappeenranta, Finland, to reach successfully its target segment (Russian consumers) with the help of digital technology in order to increase sales both in its physical shop and in online store. In order to reach the aim of the project and bring Russian consumers and the case company together by the means of electronic marketing, a marketing plan for the promotional campaigns of th...

  10. Bring Your Own Technology (BYOT to Education

    Directory of Open Access Journals (Sweden)

    Joseph M. Woodside

    2014-06-01

    Full Text Available In an effort to reduce costs and increase worker satisfaction, many businesses have implemented a concept known as Bring Your Own Device (BYOD or Bring Your Own Technology (BYOT. Similarly, many school districts are beginning to implement BYOT policies and programs to improve educational learning opportunities for students who have a wide variety of technology devices. BYOT allow districts with limited budgets enable usage of technology while improving student engagement. This paper explores the technology devices, and educational implications of policies, device management, security and included components.

  11. Bringing History Alive in the Classroom!

    Science.gov (United States)

    McRae, Lee, Ed.

    1996-01-01

    This document consists of the first four issues of a serial publication, "Bringing History Alive in the Classroom!" The volumes focus on: (1) "A Sampling of Renaissance Instruments," which includes: information on Christopher Columbus, Leondardo da Vinci, and William Shakespeare, a timeline from the middle ages through the renaissance, Queen…

  12. DNA Barcoding Investigations Bring Biology to Life

    Science.gov (United States)

    Musante, Susan

    2010-01-01

    This article describes how DNA barcoding investigations bring biology to life. Biologists recognize the power of DNA barcoding not just to teach biology through connections to the real world but also to immerse students in the exciting process of science. As an investigator in the Program for the Human Environment at Rockefeller University in New…

  13. Redfield Energy Approval

    Science.gov (United States)

    This September 19, 2016 letter from EPA approves the petition from Poet Biorefining-Lake Crystal, regarding non-This October 27, 2016 letter from EPA approves the petition from Redfield Energy, LLC, regarding non-grandfathered ethanol produced

  14. Bringing optics to Fab Labs in Europe

    Science.gov (United States)

    Adam, Aurèle; Zuidwijk, Thim; Urbach, Paul

    2017-08-01

    The Optics Group of Delft University of Technology plays a major role in teaching optics to bachelor and master students. In addition, the group has a long record of introducing, demonstrating and teaching optics to quite diverse groups of people from outside of the university. We will describe some of these activities and focus on a recently started project funded by the European Commission called Phablabs 4.0, which aims to bring photonics to European Fab labs.

  15. Editorial: Biotechnology Journal brings more than biotechnology.

    Science.gov (United States)

    Jungbauer, Alois; Lee, Sang Yup

    2015-09-01

    Biotechnology Journal always brings the state-of-the-art biotechnologies to our readers. Different from other topical issues, this issue of Biotechnology Journal is complied with a series of exiting reviews and research articles from spontaneous submissions, again, addressing society's actual problems and needs. The progress is a real testimony how biotechnology contributes to achievements in healthcare, better utilization of resources, and a bio-based economy. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Bringing the environment down to earth.

    Science.gov (United States)

    Reinhardt, F L

    1999-01-01

    The debate on business and the environment has typically been framed in simple yes-or-no terms: "Does it pay to be green?" But the environment, like other business issues, requires a more complex approach--one that demands more than such all-or-nothing thinking. Managers need to ask instead, "Under what circumstances do particular kinds of environmental investments deliver returns to shareholders?" This article presents five approaches that managers can take to identify those circumstances and integrate the environment into their business thinking. These approaches will enable companies with the right industry structure, competitive position, and managerial skills to reconcile their responsibility to shareholders with the pressure to be faithful stewards of the earth's resources. Some companies can distance themselves from competitors by differentiating their products and commanding higher prices for them. Others may be able to "manage" their competitors by imposing a set of private regulations or by helping to shape the rules written by government officials. Still others may be able to cut costs and help the environment simultaneously. Almost all can learn to improve their management of risk and thus reduce the outlays associated with accidents, lawsuits, and boycotts. And some companies may even be able to make systemic changes that will redefine competition in their markets. All five approaches can help managers bring the environment down to earth. And that means bringing the environment back into the fold of business problems and determining when it really pays to be green.

  17. Training Champions: 8 Ways to Bring out the Best in Your Major Gifts Team

    Science.gov (United States)

    Herman, Elizabeth B.

    2013-01-01

    In this article, Elizabeth B. Herman, a trainer, facilitator, and coach with 25 years' success leading higher education campaigns and advancement teams, offers the following eight ways to bring out the best in a major gifts team: (1) Match ability and temperament to the job; (2) Allow autonomy and celebrate small wins; (3) Make prompt, fair…

  18. Bringing Vision to Practice: Planning and Provisioning the New Library Resource Center

    Science.gov (United States)

    Wilson, Lisa

    2004-01-01

    The most critical factor in creating a successful school library is the development of a clear vision of the mission and functionality of this integral learning space. However, the process of bringing a vision to realization involves harsh realities and sensible planning. The budget will determine many purchasing decisions and therefore it is…

  19. Perspectives on projects, project success and team work

    OpenAIRE

    Thompson, Karen

    2015-01-01

    This paper brings together perspectives on projects, project success and team work as a background to two graphical tools for considering project success and individual capabilities for working in a project team.

  20. Bringing Pulsed Laser Welding into Production

    DEFF Research Database (Denmark)

    Olsen, Flemmming Ove

    1996-01-01

    In this paper, some research and develop-ment activities within pulsed laser welding technology at the Tech-nical University of Denmark will be described. The laser group at the Insti-tute for Manufacturing Technology has nearly 20 years of experience in laser materials process-ing. Inter......-nationally the group is mostly known for its contri-butions to the development of the laser cutting process, but further it has been active within laser welding, both in assisting industry in bringing laser welding into production in several cases and in performing fundamental R & D. In this paper some research...... activities concerning the weldability of high alloyed austenitic stainless steels for mass production industry applying industrial lasers for fine welding will be described. Studies on hot cracking sensitivity of high alloyed austenitic stainless steel applying both ND-YAG-lasers and CO2-lasers has been...

  1. Science and Sport bringing people together

    CERN Multimedia

    Staff Association

    2018-01-01

    ASCERI is the Association of the Sports Communities of the European Research Institutes and aims to contribute to a united Europe through regular sports meetings, bringing together members of public Research Institutes at European level. The Association's members come from over 42 Research Institutes spanning 15 countries. The association was born from the German "Kernforschungszentrum Karlsruhe" (KfK) football team who had the idea to play against other teams from institutes also involved in nuclear research. Therefore, six teams from different German centres were invited to take part in a "Reaktoren Fußballturnier" in Karlsruhe on 2 July 1966. Ever since, The Winter-ATOMIADE has taken place every three years and alternating with the Summer-ATOMIADE and a Mini Atomiade in between with numerous sports and leisure activities including football, skiing, golf, athletics, tennis, volleyball to name a few. CERN has been a regular participant ...

  2. Developing a web page: bringing clinics online.

    Science.gov (United States)

    Peterson, Ronnie; Berns, Susan

    2004-01-01

    Introducing clinical staff education, along with new policies and procedures, to over 50 different clinical sites can be a challenge. As any staff educator will confess, getting people to attend an educational inservice session can be difficult. Clinical staff request training, but no one has time to attend training sessions. Putting the training along with the policies and other information into "neat" concise packages via the computer and over the company's intranet was the way to go. However, how do you bring the clinics online when some of the clinical staff may still be reluctant to turn on their computers for anything other than to gather laboratory results? Developing an easy, fun, and accessible Web page was the answer. This article outlines the development of the first training Web page at the University of Wisconsin Medical Foundation, Madison, WI.

  3. Bringing Space Weather Down to Earth

    Science.gov (United States)

    Reiff, P. H.; Sumners, C.

    2005-05-01

    Most of the public has no idea what Space Weather is, but a number of innovative programs, web sites, magazine articles, TV shows and planetarium shows have taken space weather from an unknown quantity to a much more visible field. This paper reviews new developments, including the new Space Weather journal, the very popular spaceweather.com website, new immersive planetarium shows that can go "on the road", and well-publicized Sun-Earth Day activities. Real-time data and reasonably accurate spaceweather forecasts are available from several websites, with many subscribers. Even the renaissance of amateur radio because of Homeland Security brings a new generation of learners to wonder what is going on in the Sun today. The NSF Center for Integrated Space Weather Modeling has a dedicated team to reach both the public and a greater diversity of new scientists.

  4. Effective communications bring greater public acceptance

    International Nuclear Information System (INIS)

    Clawson, C.

    1992-01-01

    In 1986, GPU Nuclear Corporation announced a plan to evaporate into the atmosphere 2.3 million gal of water remaining from the Three Mile Island Unit 2 (TMI-2) accident. The water would be processed to remove most of the radioactivity, but still remaining were >1,000 Ci of tritium to be released to the atmosphere during the evaporation process. It was expected that, following regulatory approvals, it would take >2 yr to complete the process. Fed by well-established antinuclear groups, public concern about evaporating the TMI-2-accident-generated water ran high among residents living near the plant. In the years since the TMI-2 accident, GPU Nuclear had developed a highly effective communications program in the communities surrounding TMI. This ongoing program provided a solid foundation on which to create and implement a risk communications approach to community understanding and acceptance of the evaporation process

  5. Drugs Approved for Thyroid Cancer

    Science.gov (United States)

    ... Ask about Your Treatment Research Drugs Approved for Thyroid Cancer This page lists cancer drugs approved by the ... that are not listed here. Drugs Approved for Thyroid Cancer Cabozantinib-S-Malate Caprelsa (Vandetanib) Cometriq (Cabozantinib-S-Malate) Doxorubicin ...

  6. Drugs Approved for Breast Cancer

    Science.gov (United States)

    ... Ask about Your Treatment Research Drugs Approved for Breast Cancer This page lists cancer drugs approved by the ... are not listed here. Drugs Approved to Prevent Breast Cancer Evista (Raloxifene Hydrochloride) Raloxifene Hydrochloride Tamoxifen Citrate Drugs ...

  7. Bringing Seismological Research into the School Setting

    Science.gov (United States)

    Pavlis, G. L.; Hamburger, M. W.

    2004-12-01

    One of the primary goals of educational seismology programs is to bring inquiry-based research to the middle- and high-school classroom setting. Although it is often stated as a long-term goal of science outreach programs, in practice there are many barriers to research in the school setting, among them increasing emphasis on test-oriented training, decreasing interest and participation in science fairs, limited teacher confidence and experience for mentoring research, insufficient student preparedness for research projects, and the short term of university involvement (typically limited to brief one-day encounters). For the past three+ years we have tried to address these issues through a focused outreach program we have called the PEPP Research Fellows Program. This is treated as an honors program in which high school teachers in our group nominate students with interests in science careers. These students are invited to participate in the program, and those who elect to take part participate in a one-day education and training session in the fall. Rather than leave research projects completely open, we direct the students at toward one of two specific, group-oriented projects (in our case, one focusing on local recordings of mining explosions, and a second on teleseismic body-wave analysis), but we encourage them to act as independent researchers and follow topics of interest. The students then work on seismic data from the local educational network or from the IRIS facilities. Following several months of informal interaction with teachers and students (email, web conferencing, etc.), we bring the students and teachers to our university for a weekend research symposium in the spring. Students present their work in oral or poster form and prizes are given for the best papers. Projects range from highly local projects (records of seismic noise at school X) to larger-scale regional projects (analysis of teleseismic P-wave delays at PEPP network stations) From 20 to

  8. Bringing science to the policy table

    CERN Multimedia

    2014-01-01

    “They shall beat their swords into plowshares, and their spears into pruning hooks. Nation shall not lift up sword against nation. Neither shall they learn war anymore." So says Isaiah 2:4, as transcribed on the famous wall in Ralph Bunche park, just the other side of 1st Avenue from the UN’s New York headquarters, where we held a celebration of our 60th anniversary year on Monday 20 October. I used the quotation in my opening address, since it is such a perfect fit to the theme of 60 years of science for peace and development.   The event was organised with the United Nations Economic and Social Council, ECOSOC, in the framework of CERN’s observer status at the UN, and although focused on CERN, its aim was broader. Presentations used CERN as an example to bring out the vital importance of science in general to the themes of peace and development. The event was presided over by Martin Sajdik, President of ECOSOC, and we were privileged to have presentat...

  9. Poster power brings together electronics community

    CERN Multimedia

    2006-01-01

    An 'Electronics at CERN' poster session was displayed on the mezzanine in building 500 for two days from 30 November. The display consisted of 20 posters and brought together a wide range of electronic projects designed and assembled by CERN teams and other collaborators involved in the building of the LHC. This was the first time this event had been held. As its organiser John Evans (IT/DES) explained, 'the idea came from the experience of attending conferences outside CERN, where you may find projects from CERN you didn't know about. It's nice to bring them together so we can all benefit from the efforts made.' The work on show spanned different departments and experiments, ranging from microelectronics to equipment designed for giant magnets. The invited audience was equally broad and included engineers, physicists as well as the electronics community at CERN. An informal gathering of all the exhibitors also offered an opportunity to view and discuss the work over a cup of coffee. 'The poster session acts...

  10. Poet Marion Approval

    Science.gov (United States)

    This update August 9, 2016 letter from EPA approves, with modifications, the petition from Poet Biorefining-North Manchester, LLC, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable

  11. Poet Portland Approval

    Science.gov (United States)

    This update August 9, 2016 letter from EPA approves the petition, with modifications, from Poet Biorefining-Portland, LLC, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel

  12. Poet North Manchester Approval

    Science.gov (United States)

    This update August 9, 2016 letter from EPA approves, with modifications, the petition from Poet Biorefining-North Manchester, LLC, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable

  13. Poet Alexandria Approval

    Science.gov (United States)

    This update August 9, 2016 letter from EPA approves, with modifications, the petition from Poet Biorefining-Alexandria, LLC, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel

  14. Poet Laddonia Approval

    Science.gov (United States)

    This update Auugust 9, 2016 letter from EPA approves with modifications, the petition from Poet Biorefining Laddonia, Poet Laddonia Facility, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act f

  15. Drugs Approved for Neuroblastoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for neuroblastoma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  16. Drugs Approved for Leukemia

    Science.gov (United States)

    This page lists cancer drugs approved by the FDA for use in leukemia. The drug names link to NCI's Cancer Drug Information summaries. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  17. Drugs Approved for Retinoblastoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for retinoblastoma. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  18. Premarket Approvals (PMA)

    Data.gov (United States)

    U.S. Department of Health & Human Services — Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An...

  19. Bringing Home the “Danish” Bacon

    DEFF Research Database (Denmark)

    Higgins, David M.; Mordhorst, Mads

    2015-01-01

    A substantial literature documents the importance of trademarks and brands to business success. How does this relationship change when we enlarge our focus from individual firms to industries and nations? This articles examines the dominance of Danish bacon in Britain between the late nineteenth...

  20. Bringing customer focus to power generation

    Energy Technology Data Exchange (ETDEWEB)

    Mahoney, J.V. [USGen Power Services (United States)

    1997-02-01

    The restructuring of the power generation industry and the impact it will have on a company`s success was discussed. Some companies are following one of three distinct strategies for survival, the GENCO, MARKETCO and TRADECO. The GENCO focuses on aggregating low cost, kick butt generation assets that could be either regionally concentrated or geographically distributed. The TRADECO invests in few, or even no, assets. Its only objective is to maximize net income. The MARKETCO structure focuses on understanding and meeting customers` needs. The MARKETCO puts as much value in aggregating `load` as it does on assets. It was suggested that the MARKETCO was the quickest path to success in the restructured electric industry, since it is plainly evident that in the New Millenium the customer will be king, and companies will not survive unless they focus the majority of their efforts on the customer.

  1. Bringing NASA Technology Down to Earth

    Science.gov (United States)

    Lockney, Daniel P.; Taylor, Terry L.

    2018-01-01

    Whether putting rovers on Mars or sustaining life in extreme conditions, NASA develops technologies to solve some of the most difficult challenges ever faced. Through its Technology Transfer Program, the agency makes the innovations behind space exploration available to industry, academia, and the general public. This paper describes the primary mechanisms through which NASA disseminates technology to solve real-life problems; illustrates recent program accomplishments; and provides examples of spinoff success stories currently impacting everyday life.

  2. Bringing robotics technology down to Earth

    International Nuclear Information System (INIS)

    Fuller, B.R.

    1997-01-01

    Robotics technology is successfully being transitioned from space to terrestrial applications. It is being modified and enhanced to help in the US DOE's Environmental Restoration and Waste Management Program. Some examples of these applications, ranging from large multijointed manipulators to autonomously navigated remote vehicles, are outlined in this article. They include the following: underground storage tank technology demonstration; light-duty utility arm system; remotely controlled material-handling system; remotely operated excavator; self-guided transfer vehicle. 10 figs

  3. Theoretical Approaches on Successful Email Marketing Campaigns

    Directory of Open Access Journals (Sweden)

    Camelia Budac

    2016-01-01

    This paper aims to bring some clarifications on what could bring success to email marketingcampaigns. Responses are related to how sent emails can draw the attention of people (ie how theycan be observed, given that, users’ inboxes are invaded by messages of all kinds, how to measurethe results of a campaign and which are the best practices through which we can get higher returnsfrom email marketing campaigns.

  4. Smart Technology Brings Power to the People

    Energy Technology Data Exchange (ETDEWEB)

    Hammerstrom, Donald J.; Gephart, Julie M.

    2006-12-01

    Imagine you’re at home one Saturday morning on the computer, as your son takes a shower, your daughter is watching TV, and a load of laundry is in your washer and dryer. Meanwhile, the fragrance of fresh-brewed coffee fills the house. You hear a momentary beep from the dryer that tells you that if you were to look, a high-energy price indicator would be displayed on the front panels of some of your favorite appliances. This tells you that you could save money right now by using less energy. (You’ve agreed to this arrangement to help your utility avoid a substation upgrade. In return, you get a lower rate most of the time.) So you turn off some of the unneeded lights in your home and opt to wait until evening to run the dishwasher. Meanwhile, some of your largest appliances have automatically responded to this signal and have already reduced your home’s energy consumption, saving you money. On January 11, 2006, demonstration projects were launched in 200 homes in the Pacific Northwest region of the United States to test and speed adoption of new smart grid technologies that can make the power grid more resilient and efficient. Pacific Northwest National Laboratory, a U.S. Department of Energy national laboratory in Richland, Washington, is managing the yearlong study called the Pacific Northwest GridWise™ Testbed Demonstration, a project funded primarily by DOE. Through the GridWise™ Demonstration projects, researchers are gaining insight into energy consumers’ behavior while testing new technologies designed to bring the electric transmission system into the information age. Northwest utilities, appliance manufacturers and technology companies are also supporting this effort to demonstrate the devices and assess the resulting consumer response. A combination of devices, software and advanced analytical tools will give homeowners more information about their energy use and cost, and we want to know if this will modify their behavior. Approximately 100

  5. 49 CFR 1522.121 - Security threat assessments for personnel of TSA-approved validation firms.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Security threat assessments for personnel of TSA... FOR ALL MODES OF TRANSPORTATION TSA-APPROVED VALIDATION FIRMS AND VALIDATORS TSA-Approved Validation... for personnel of TSA-approved validation firms. Each of the following must successfully complete a...

  6. An Experienced Worker's View of the Workplace: Caring about Employees Brings Success to Companies.

    Science.gov (United States)

    Alvarez, Carl

    1992-01-01

    A bakery foreman states that employers need (1) a sustained standard of living; (2) job security; (3) creativity; and (4) dignity in work. He suggests that foreman must find ways to increase productivity while treating employees as individuals. (SK)

  7. Three Drugs Approved for Urothelial Carcinoma by FDA.

    Science.gov (United States)

    2017-07-01

    The FDA has approved one PD-1 checkpoint inhibitor, pembrolizumab, and two PD-L1 checkpoint inhibitors, avelumab and durvalumab, to treat metastatic urothelial carcinoma in patients whose disease continues to progress despite platinum-based chemotherapy. This brings the total number of checkpoint inhibitors for the disease to five, prompting questions about how best to use them. ©2017 American Association for Cancer Research.

  8. Vedolizumab: first global approval.

    Science.gov (United States)

    Poole, Raewyn M

    2014-07-01

    Vedolizumab [Entyvio(®) (US, Europe)], a humanized monoclonal antibody α4β7 integrin receptor antagonist, has been developed by Millennium Pharmaceuticals (d/b/a Takeda Pharmaceuticals International) for the treatment of ulcerative colitis and Crohn's disease. Vedolizumab has received its first global approval for the treatment of ulcerative colitis and Crohn's disease in the US, for use in adult patients with moderate-to-severe disease who have had an inadequate response, loss of response or intolerance to one or more standard therapies (corticosteroids, immunomodulators or tumour necrosis factor-α inhibitor) or demonstrated dependence on corticosteroids. Vedolizumab has since been approved for ulcerative colitis and Crohn's disease in the EU, Norway, Iceland and Liechtenstein. This article summarizes the milestones in the development of vedolizumab leading to its first approval for the treatment of ulcerative colitis and Crohn's disease.

  9. Bringing Superconductor Digital Technology to the Market Place

    Science.gov (United States)

    Nisenoff, Martin

    The unique properties of superconductivity can be exploited to provide the ultimate in electronic technology for systems such as ultra-precise analogue-to-digital and digital-to-analogue converters, precise DC and AC voltage standards, ultra high speed logic circuits and systems (both digital and hybrid analogue-digital systems), and very high throughput network routers and supercomputers which would have superior electrical performance at lower overall electrical power consumption compared to systems with comparable performance which are fabricated using conventional room temperature technologies. This potential for high performance electronics with reduced power consumption would have a positive impact on slowing the increase in the demand for electrical utility power by the information technology community on the overall electrical power grid. However, before this technology can be successfully brought to the commercial market place, there must be an aggressive investment of resources and funding to develop the required infrastructure needed to yield these high performance superconductor systems, which will be reliable and available at low cost. The author proposes that it will require a concerted effort by the superconductor and cryogenic communities to bring this technology to the commercial market place or make it available for widespread use in scientific instrumentation.

  10. Bringing computational science to the public.

    Science.gov (United States)

    McDonagh, James L; Barker, Daniel; Alderson, Rosanna G

    2016-01-01

    The increasing use of computers in science allows for the scientific analyses of large datasets at an increasing pace. We provided examples and interactive demonstrations at Dundee Science Centre as part of the 2015 Women in Science festival, to present aspects of computational science to the general public. We used low-cost Raspberry Pi computers to provide hands on experience in computer programming and demonstrated the application of computers to biology. Computer games were used as a means to introduce computers to younger visitors. The success of the event was evaluated by voluntary feedback forms completed by visitors, in conjunction with our own self-evaluation. This work builds on the original work of the 4273π bioinformatics education program of Barker et al. (2013, BMC Bioinform. 14:243). 4273π provides open source education materials in bioinformatics. This work looks at the potential to adapt similar materials for public engagement events. It appears, at least in our small sample of visitors (n = 13), that basic computational science can be conveyed to people of all ages by means of interactive demonstrations. Children as young as five were able to successfully edit simple computer programs with supervision. This was, in many cases, their first experience of computer programming. The feedback is predominantly positive, showing strong support for improving computational science education, but also included suggestions for improvement. Our conclusions are necessarily preliminary. However, feedback forms suggest methods were generally well received among the participants; "Easy to follow. Clear explanation" and "Very easy. Demonstrators were very informative." Our event, held at a local Science Centre in Dundee, demonstrates that computer games and programming activities suitable for young children can be performed alongside a more specialised and applied introduction to computational science for older visitors.

  11. Successful ageing

    DEFF Research Database (Denmark)

    Bülow, Morten Hillgaard; Söderqvist, Thomas

    2014-01-01

    Since the late 1980s, the concept of ‘ successful ageing’ has set the frame for discourse about contemporary ageing research. Through an analysis of the reception to John W. Rowe and Robert L. Kahn's launch of the concept of ‘ successful ageing’ in 1987, this article maps out the important themes...... and discussions that have emerged from the interdisciplinary field of ageing research. These include an emphasis on interdisciplinarity; the interaction between biology, psycho-social contexts and lifestyle choices; the experiences of elderly people; life-course perspectives; optimisation and prevention...... strategies; and the importance of individual, societal and scientific conceptualisations and understandings of ageing. By presenting an account of the recent historical uses, interpretations and critiques of the concept, the article unfolds the practical and normative complexities of ‘ successful ageing’....

  12. Citation Success

    DEFF Research Database (Denmark)

    Vaio, Gianfranco Di; Waldenström, Daniel; Weisdorf, Jacob Louis

    2012-01-01

    This study examines the determinants of citation success among authors who have recently published their work in economic history journals. Besides offering clues about how to improve one's scientific impact, our citation analysis also sheds light on the state of the field of economic history...... find similar patterns when assessing the same authors' citation success in economics journals. As a novel feature, we demonstrate that the diffusion of research — publication of working papers, as well as conference and workshop presentations — has a first-order positive impact on the citation rate........ Consistent with our expectations, we find that full professors, authors appointed at economics and history departments, and authors working in Anglo-Saxon and German countries are more likely to receive citations than other scholars. Long and co-authored articles are also a factor for citation success. We...

  13. CORN, LP Goldfield Approval

    Science.gov (United States)

    This November 19, 2015 letter from EPA approves the petition from CORN, LP, Goldfield facility, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel (D-code 6) RINs under the RFS pro

  14. Poet Fostoria Approval

    Science.gov (United States)

    This August 9, 2016 letter from EPA approves, with modifications, the petition from Poet Biorefining-Fostoria, LLC, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel (D-code 6)

  15. Poet Lake Crystal Approval

    Science.gov (United States)

    This September 19, 2016 letter from EPA approves the petition from Poet Biorefining-Lake Crystal, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel (D-code 6) RINs under the RFS

  16. Poet Leipsic Approval

    Science.gov (United States)

    This August 9, 2016 letter from EPA approves,wtih modifications, the petition from Poet Biorefining-Leipsic, LLC, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel (D-code 6) RINs

  17. Drugs Approved for Rhabdomyosarcoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for rhabdomyosarcoma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries. There may be drugs used in rhabdomyosarcoma that are not listed here.

  18. Citation Success

    DEFF Research Database (Denmark)

    Di Vaio, Gianfranco; Waldenström, Daniel; Weisdorf, Jacob Louis

    affects citations. In regard to author-specific characteristics, male authors, full professors and authors working economics or history departments, and authors employed in Anglo-Saxon countries, are more likely to get cited than others. As a ‘shortcut' to citation success, we find that research diffusion...

  19. Successful modeling?

    Science.gov (United States)

    Lomnitz, Cinna

    Tichelaar and Ruff [1989] propose to “estimate model variance in complicated geophysical problems,” including the determination of focal depth in earthquakes, by means of unconventional statistical methods such as bootstrapping. They are successful insofar as they are able to duplicate the results from more conventional procedures.

  20. Successful ageing

    DEFF Research Database (Denmark)

    Kusumastuti, Sasmita; Derks, Marloes G. M.; Tellier, Siri

    2016-01-01

    BACKGROUND: Ageing is accompanied by an increased risk of disease and a loss of functioning on several bodily and mental domains and some argue that maintaining health and functioning is essential for a successful old age. Paradoxically, studies have shown that overall wellbeing follows a curvili...

  1. Crowds bringing power, payoff to entrepreneurs

    Energy Technology Data Exchange (ETDEWEB)

    Madison, Alison L.

    2012-06-07

    Monthly economic diversity column for Tri-City Herald; excerpt here: As I walk through my garden, marveling at the fresh treats in store and wondering what I’ll do when 47 bell peppers ripen at once, I also wistfully think of the one crop that continues to elude even the greenest of thumbs. The money tree. It’s fun to imagine the possibilities a money tree would offer, branch after branch reaching out to support one’s life pursuits. Go ahead, take a minute... Back in reality, I realize how valuable this concept could be to many entrepreneurs out there in possession of the next game-changing idea, without the capital to move forward. Enter Kickstarter.com, a highly successful example in a growing genre of websites devoted to crowdfunding. In the past few years, crowdfunding has become a disruptive element in the startup process, enabling inventors and promoters of numerous causes to generate capital through a consensus of virtual supporters, a money giving tree of sorts, without sacrificing equity in their projects or circling the globe chasing venture capital and angel money.

  2. Linaclotide: first global approval.

    Science.gov (United States)

    McWilliams, Vanessa; Whiteside, Glenn; McKeage, Kate

    2012-11-12

    Linaclotide is a once-daily, orally administered, first-in-class agonist of guanylate cyclase-C that is minimally absorbed. It is being developed to treat gastrointestinal disorders by Ironwood Pharmaceuticals and its partners, Forest Laboratories (North America), Almirall (Europe) and Astellas Pharma (Asia-Pacific). Linaclotide has received its first global approval in the US for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC), and a marketing submission has been filed in the EU for IBS-C. This article summarizes the milestones in the development of linaclotide leading to this first approval for IBS-C and CIC. This profile has been extracted and modified from the Adis R&D Insight drug pipeline database. Adis R&D Insight tracks drug development worldwide through the entire development process, from discovery, through pre-clinical and clinical studies to market launch.

  3. Neratinib: First Global Approval.

    Science.gov (United States)

    Deeks, Emma D

    2017-10-01

    Neratinib (Nerlynx™) is an oral, irreversible inhibitor of the human epidermal growth factor receptors HER1 (EGFR), HER2 and HER4. The drug originally arose from research by Wyeth (now Pfizer) and is now being developed by Puma Biotechnology primarily for the treatment of HER2-positive (HER+) breast cancer. Neratinib is approved in the USA for the extended adjuvant treatment of patients with HER2+ early-stage breast cancer who have been previously treated with a trastuzumab-based adjuvant regimen, and is in the preregistration phase for this indication in the EU. Neratinib, as monotherapy and/or combination therapy, is also in phase 3 development for metastatic breast cancer and in phase 1/2 development for advanced breast cancer and other solid tumours, including non-small cell lung cancer, colorectal cancer and glioblastoma. This article summarizes the milestones in the development of neratinib leading to this first approval for breast cancer.

  4. Avelumab: First Global Approval.

    Science.gov (United States)

    Kim, Esther S

    2017-05-01

    Avelumab (Bavencio ® ) is an intravenously administered programmed cell death ligand-1-blocking human antibody initially developed by EMD Serono Inc. (the biopharmaceutical division of Merck KGaA, Darmstadt, Germany) [now jointly developed and commercialized by EMD Serono Inc. and Pfizer] for the treatment of various tumours. It has received accelerated approval in the USA for the treatment of metastatic Merkel cell carcinoma (mMCC) in adults and paediatric patients aged ≥12 years. The marketing authorization application for avelumab in the treatment of mMCC is undergoing regulatory review in the EU, the biologics license application for avelumab in the treatment of urothelial carcinoma is undergoing priority review by the FDA, and avelumab is in various stages of development internationally for a variety of cancers. This article summarizes the milestones in the development of avelumab leading to this first approval for mMCC.

  5. Bring your own device (BYOD) to work trend report

    CERN Document Server

    Hayes, Bob

    2013-01-01

    Bring Your Own Device (BYOD) to Work examines the emerging BYOD (Bring Your Own Device to work) trend in corporate IT. BYOD is the practice of employees bringing personally-owned mobile devices (e.g., smartphones, tablets, laptops) to the workplace, and using those devices to access company resources such as email, file servers, and databases. BYOD presents unique challenges in data privacy, confidentiality, security, productivity, and acceptable use that must be met proactively by information security professionals. This report provides solid background on the practice, original res

  6. Gender equity and tobacco control: bringing masculinity into focus.

    Science.gov (United States)

    Morrow, Martha; Barraclough, Simon

    2010-03-01

    Gender is a key but often overlooked--determinant of tobacco use, especially in Asia, where sex-linked differences in prevalence rates are very large. In this article we draw upon existing data to consider the implications of these patterns for gender equity and propose approaches to redress inequity through gender-sensitive tobacco control activities. International evidence demonstrates that, in many societies, risk behaviours (including tobacco use) are practised substantially more by men and boys, and are also viewed as expressions of masculine identity. While gender equity focuses almost exclusively on the relative disadvantage of girls and women that exists in most societies, disproportionate male use of tobacco has profound negative consequences for men (as users) and for women (nonusers). Surprisingly, health promotion and tobacco control literature rarely focus on the role of gender in health risks among boys and men. However, tobacco industry marketing has masterfully incorporated gender norms, and also other important cultural values, to ensure its symbols are context-specific. By addressing gender-specific risks within the local cultural context--as countries are enjoined to do within the Framework Convention's Guiding Principles--it may be possible to accelerate the impact of mechanisms such as tobacco pricing, restrictions on marketing, smoking bans and provision of accurate information. It is essential that we construct a new research-to-policy framework for gender-sensitive tobacco control. Successful control of tobacco can only be strengthened by bringing males, and the concept of gender as social construction, back into our research and discussion on health and gender equity.

  7. Dubna at Play Exhibition Science Bringing Nations Together

    CERN Multimedia

    1999-01-01

    The small town of Dubna brings together the advantages of urban and country lifestyles. Dubna people spend a large part of their time outdoors taking part in all kind of sports or simply enjoying the beautiful surroundings.

  8. Dubna at Play Exhibition Science Bringing Nations Together

    CERN Multimedia

    1997-01-01

    The small town of Dubna brings together the advantages of urban and country lifestyles. Dubna people spend a large part of their time outdoors taking part in all kind of sports or simply enjoying the beautiful surroundings.

  9. A Review of Bring Your Own Device on Security Issues

    OpenAIRE

    Morufu Olalere; Mohd Taufik Abdullah; Ramlan Mahmod; Azizol Abdullah

    2015-01-01

    Mobile computing has supplanted internet computing because of the proliferation of cloud-based applications and mobile devices (such as smartphones, palmtops, and tablets). As a result of this, workers bring their mobile devices to the workplace and use them for enterprise work. The policy of allowing the employees to work with their own personal mobile devices is called Bring Your Own Devices (BYOD). In this article, ...

  10. Supercollider: Footprint approved

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    With the 'footprint' - the precise location of the 87-kilometre US Superconducting Supercollider, SSC, and its ancillary buildings - now approved, teams of specialists commissioned by the State of Texas swing into action to procure the 17,000 acres (69 million square metres) of land covered by the project. With the SSC Laboratory in Ellis County and the US Department of Energy (DoE, the overseeing government agency) both hiring manpower for this project to collide 20 TeV (20,000 GeV) proton beams before the end of the century, the host State of Texas is providing a helping hand

  11. Successful Aging

    Directory of Open Access Journals (Sweden)

    Taufiqurrahman Nasihun

    2015-06-01

    Full Text Available The emerging concept of successful aging is based on evidence that in healthy individual when they get aged, there are  considerable variations in physiological functions alteration. Some people exhibiting greater, but others very few or no age related alteration. The first is called poor aging and the later is called successful pattern of aging (Lambert SW, 2008. Thus, in the simple words the successful aging concept is define as an opportunity of old people to stay  active and productive condition despite they get aged chronologically. Aging itself might be defined as the progressive accumulation of changes with time associated with or responsible for the ever-increasing susceptibility to disease and death which accompanies advancing age (Harman D, 1981. The time needed to accumulate changes is attributable to aging process. The marked emerging questions are how does aging happen and where does aging start? To answer these questions and because of the complexity of aging process, there are more than 300 aging theories have been proposed to explain how and where aging occured and started respectively. There are too many to enumerate theories and classification of aging process. In summary, all of these aging theories can be grouped into three clusters: 1. Genetics program theory, this theory suggests that aging is resulted from program directed by the genes; 2. Epigenetic theory, in these theory aging is resulted from environmental random events not determined by the genes; 3. Evolutionary theory, which propose that aging is a medium for disposal mortal soma in order to avoid competition between organism and their progeny for food and space, did not try to explain how aging occur, but possibly answer why aging occur (De la Fuente. 2009. Among the three groups of aging theories, the epigenetic theory is useful to explain and try to solve the enigma of aging which is prominently caused by internal and external environmental influences

  12. BioVersys Works to Bring Antibiotic Resistance to an End.

    Science.gov (United States)

    Tigges, Marcel; Gitzinger, Marc

    2014-12-01

    BioVersys, founded in 2008, is working on bringing a technology for screening and for the development of 'transcriptional regulator inhibiting compounds' (TRICs) to patients in order to overcome antibiotic resistance. The co-founders share their view on what makes successful scientists pursue a career as start-up entrepreneurs rather than a classic academic career. They describe the history and milestones of their company, and how their everyday work differs from that of peers in an academic or industrial research setting.

  13. Guidance for package approvals in the United Kingdom

    International Nuclear Information System (INIS)

    Morgan-Warren, E.J.

    2004-01-01

    Approval is required under the transport regulations for a wide range of package designs and operations, and applications for competent authority approval and validation are received from many sources, both in the UK and overseas. To assist package designers and applicants for approval, and to promote consistency in applications and their assessment, the UK Department for Transport issues guidance on the interpretation of the transport regulations and the requirements of an application for approval and its supporting safety case. The general guidance document, known as the Guide to an Application for UK Competent Authority Approval of Radioactive Material in Transport, has been issued for many years and updated to encompass the provisions of each successive edition of the IAEA transport regulations. The guide has been referred to in a number of international fora, including PATRAM, and was cited as a 'good practice' in the report of the IAEA TRANSAS appraisal of the UK in 2002. Specialist guides include the Guide to the Suitability of Elastomeric Seal Materials, which is the subject of a separate paper in this conference, and the Guide to the Approval of Freight Containers as Types IP-2 and IP-3 Packages. This paper discusses the guidance material and summarises the administrative and technical information required in support of applications for approval of package designs, special form and low-dispersible radioactive materials, shipments, special arrangements, modifications and validations. (author)

  14. The Evolution of Approval Services.

    Science.gov (United States)

    Warzala, Martin

    1994-01-01

    Describes major developments in book approval plans used by academic libraries for acquisition and for information dissemination and document distribution services based on approval-like concepts. Topics addressed include publishers; marketing; the impact of library automation; value-added services; the economic climate; the influence of…

  15. Bring out your codes! Bring out your codes! (Increasing Software Visibility and Re-use)

    Science.gov (United States)

    Allen, A.; Berriman, B.; Brunner, R.; Burger, D.; DuPrie, K.; Hanisch, R. J.; Mann, R.; Mink, J.; Sandin, C.; Shortridge, K.; Teuben, P.

    2013-10-01

    Progress is being made in code discoverability and preservation, but as discussed at ADASS XXI, many codes still remain hidden from public view. With the Astrophysics Source Code Library (ASCL) now indexed by the SAO/NASA Astrophysics Data System (ADS), the introduction of a new journal, Astronomy & Computing, focused on astrophysics software, and the increasing success of education efforts such as Software Carpentry and SciCoder, the community has the opportunity to set a higher standard for its science by encouraging the release of software for examination and possible reuse. We assembled representatives of the community to present issues inhibiting code release and sought suggestions for tackling these factors. The session began with brief statements by panelists; the floor was then opened for discussion and ideas. Comments covered a diverse range of related topics and points of view, with apparent support for the propositions that algorithms should be readily available, code used to produce published scientific results should be made available, and there should be discovery mechanisms to allow these to be found easily. With increased use of resources such as GitHub (for code availability), ASCL (for code discovery), and a stated strong preference from the new journal Astronomy & Computing for code release, we expect to see additional progress over the next few years.

  16. Bringing the LHC and ATLAS to a regional planetarium

    CERN Document Server

    Schwienhorst, Reinhard

    2011-01-01

    An outreach effort has started at Michigan State University to bring particle physics, the Large Hadron Collider, and the ATLAS experiment to a general audience at the Abrams planetarium on the MSU campus. A team of undergraduate students majoring in physics, communications arts & sciences, and journalism are putting together short clips about ATLAS and the LHC to be shown at the planetarium.

  17. Driven: Bringing German Auto Concepts to the Classroom

    Science.gov (United States)

    Adney, Cara

    2012-01-01

    A world away from the red dirt of Oklahoma, David Shields and Shelly Smith felt right at home. A national grant took the Meridian Technology Center automotive teachers on a trip to Germany that car lovers only dream about. The tour to the major automakers last summer has them geared up and bringing fresh ideas to the classroom. They spent four…

  18. Practical ways of bringing innovations and creativity into the school ...

    African Journals Online (AJOL)

    This article describes the practical ways of bringing innovations and creativity into the school library media programme in Nigeria. Discussion focused on areas on creativity and innovations such as environmental design, staffing, outreach activities, library cooperation, and introduction of ICT system. Keywords: Innovations ...

  19. "Bring Your Own Device": Considering Potential Risks to Student Health

    Science.gov (United States)

    Merga, Margaret K.

    2016-01-01

    Background and context: Schools in Australia and internationally are increasingly adopting a Bring Your Own Device (BYOD) approach to teaching and learning. The review: While discussion of a BYOD approach has taken place, there is a dearth of consideration of the potential impact of BYOD policy on student health. Implementation of a BYOD policy…

  20. Bring Your Own Digital Device in Teacher Education

    Science.gov (United States)

    Newhouse, C. Paul; Cooper, Martin; Pagram, Jeremy

    2015-01-01

    This article reports on an investigation to advise a teacher education institution on the feasibility of having a "Bring Your Own Digital Device" policy for students. The investigation built on components of two research projects while adding the comprehensive testing of representative potential hardware and software platforms. The…

  1. Biblionef SA: Bringing books to the bookless | Williams | Innovation

    African Journals Online (AJOL)

    Biblionef SA: Bringing books to the bookless. Jean Williams. Abstract. No abstract available. Innovation (2003) No. 26, pp 43-47. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians ...

  2. Bringing Foreign Language Learning into the 21st century | Thomas ...

    African Journals Online (AJOL)

    Bringing Foreign Language Learning into the 21st Century. The different challenges facing foreign language lecturers are considered as well as the different methods used to teach a foreign language. Technology and multimedia are proposed not only as tools and supports but also as a possible solution. With the change ...

  3. Bringing climate change into natural resource management: proceedings.

    Science.gov (United States)

    L. Joyce; R. Haynes; R. White; R.J. Barbour

    2007-01-01

    These are the proceedings of the 2005 workshop titled implications of bringing climate into natural resource management in the Western United States. This workshop was an attempt to further the dialogue among scientists, land managers, landowners, interested stakeholders and the public about how individuals are addressing climate change in natural resource management....

  4. Bringing Curriculum Theory and Didactics Together: A Deweyan Perspective

    Science.gov (United States)

    Deng, Zongyi

    2016-01-01

    Using Dewey's method of resolution for resolving a dualism exemplified in "The Child and the Curriculum," this article reconciles and brings together two rival schools of thought--curriculum theory and didactics--in China. The central thesis is that the rapprochement requires a reconceptualisation of curriculum theory and didactics in…

  5. Bringing Knowledge Back In: Perspectives from Liberal Education

    Science.gov (United States)

    Deng, Zongyi

    2018-01-01

    From the vantage point of liberal education, this article attempts to contribute to the conversation initiated by Michael Young and his colleagues on 'bringing knowledge back' into the current global discourse on curriculum policy and practice. The contribution is made through revisiting the knowledge-its-own-end thesis associated with Newman and…

  6. Electronic Approval of Invoices (AEF)

    CERN Document Server

    2004-01-01

    With a view to the simplification of administrative procedures, AS and FI Departments have completed the second phase of the new procedure for the electronic approval of invoices via the EDH application. The aim of this new procedure is to rationalise the invoice approval process, notably by eliminating paper copies from the approval circuit. This will simplify the processing of invoices and facilitate their timely settlement, while at the same time maintaining a high level of security. Phase II includes handling the electronic approval process of invoices whose amounts do not correspond exactly to those of the associated orders. In such cases, budgetary approval is required for the entire invoiced amount. Further information can be obtained at : http://ais.cern.ch/projs/AEF/help/F_help.htm Phase II of the procedure will be introduced gradually with effect from April 2004. Finance Department, Accounts Payable Section Tel: 72295 Organisation and Procedures Tel: 75885 Information Technologies Department,...

  7. Template for letter of approval by Research Supervisor

    International Development Research Centre (IDRC) Digital Library (Canada)

    Liliane Castets-Poupart

    a) As research supervisor of J. Smith, I confirm that I approve and support the research proposal submitted by the candidate. b) J. Smith has successfully completed the following course(s):. STAT 890: Statistics, Survey Design and Analysis INAF 540: International Affairs Dynamics. ECON 700: Qualitative Research Data.

  8. Biosimilars approval process.

    Science.gov (United States)

    Zuñiga, Leyre; Calvo, Begoña

    2010-04-01

    For similar biological medicinal products, the so-called biosimilars, clinical trials are required rather than just the bioequivalence studies required to support the registration of a generic small molecule drug product. The EU Directive 2001/83/EC, as amended, stated that where a biological medicinal product which is similar to a reference biological product, does not meet the conditions in the definition of generic medicinal products the results of appropriate pre-clinical tests or clinical trials relating to these conditions must be provided. The challenge is to determine the exact nature of the non-clinical and clinical programme required to gain regulatory approval. The applicant is encouraged to provide a detailed description of the strategy used to demonstrate the biosimilar and the reference product have similar profiles in terms of quality, safety and efficacy. The extent to which comparability can be proven will have quite an impact on how many non-clinical and clinical studies the biosimilar applicant will be required to conduct. The dossier submitted by the applicant to the EMEA should cover all aspects of the comparability assessment and must include data on possible unwanted immune reactions to the therapeutic protein. Post-marketing pharmacovigilance plans are also expected to be included in the biosimilar dossier. Copyright 2009 Elsevier Inc. All rights reserved.

  9. Drugs Approved for Kidney (Renal Cell) Cancer

    Science.gov (United States)

    ... Your Treatment Research Drugs Approved for Kidney (Renal Cell) Cancer This page lists cancer drugs approved by the ... not listed here. Drugs Approved for Kidney (Renal Cell) Cancer Afinitor (Everolimus) Aldesleukin Avastin (Bevacizumab) Axitinib Bevacizumab Cabometyx ( ...

  10. Approval plans issues and innovations

    CERN Document Server

    Katz, Linda S

    2013-01-01

    How can you, as an acquisition librarians, keep current on the output of hundreds of publishers? The answer, of course, is that you cannot. For over 30 years, approval plans have been used by librarians to acquire current titles, save staff time, and build core collections. Even today, these reasons seem appropriate, as libraries try to maintain up-to-date collections and control personnel and operating budgets. However, as shown in Approval Plans: Issues and Innovations, the use of approval plans is not so simple and straightforward; their use is subject to complex procedures and policies--an

  11. Bring Your Own Device and Nurse Managers' Decision Making.

    Science.gov (United States)

    Martinez, Karen; Borycki, Elizabeth; Courtney, Karen L

    2017-02-01

    The Bring Your Own Device phenomenon is important in the healthcare environment because this trend is changing the workplace in healthcare organizations, such as British Columbia. At present, there is little research that exists in Canada to provide a distinct understanding of the complexities and difficulties unique to this phenomenon within the nursing practice. This study focused on the experiences and perceptions of nurse managers regarding how they make decisions on the use of personal handheld devices in the workplace. Telephone interviews (N = 10) and qualitative descriptive analysis were used. Four major themes emerged: (1) management perspective, (2) opportunities, (3) disadvantages, and (4) solutions. Nurse managers and other executives in healthcare organizations and health information technology departments need to be aware of the practice and organizational implications of the Bring Your Own Device movement.

  12. Design of extraction system in BRing at HIAF

    Science.gov (United States)

    Ruan, Shuang; Yang, Jiancheng; Zhang, Jinquan; Shen, Guodong; Ren, Hang; Liu, Jie; Shangguan, Jingbing; Zhang, Xiaoying; Zhang, Jingjing; Mao, Lijun; Sheng, Lina; Yin, Dayu; Wang, Geng; Wu, Bo; Yao, Liping; Tang, Meitang; Cai, Fucheng; Chen, Xiaoqiang

    2018-06-01

    The Booster Ring (BRing), which is the key part of HIAF (High Intensity heavy ion Accelerator Facility) complex at IMP (Institute of Modern Physics, Chinese Academy of Sciences), can provide uranium (A / q = 7) beam with a wide extraction energy range of 200-800 MeV/u. To fulfill a flexible beam extraction for multi-purpose experiments, both fast and slow extraction systems will be accommodated in the BRing. The fast extraction system is used for extracting short bunched beam horizontally in single-turn. The slow extraction system is used to provide quasi-continuous beam by the third order resonance and RF-knockout scheme. To achieve a compact structure, the two extraction systems are designed to share the same extraction channel. The general design of the fast and slow extraction systems and simulation results are discussed in this paper.

  13. 48 CFR 750.7105 - Approving authorities.

    Science.gov (United States)

    2010-10-01

    ... CONTRACT MANAGEMENT EXTRAORDINARY CONTRACTUAL ACTIONS Extraordinary Contractual Actions To Protect Foreign Policy Interests of the United States 750.7105 Approving authorities. All authority to approve actions...

  14. BRINGING STRATEGIC THINKING TO A CHINESE TOBACCO LOGISTICS CENTER

    OpenAIRE

    Zhao, Liubaihe

    2012-01-01

    Recently operation and logistics activities have played a more strategic role as tobacco business enterprises’ main functions. Because of the increasing costs of e.g. warehousing and inventory, transportation, personnel and other relevant materials, the different parties in the supply chain are facing more challenges and opportunities. On the one hand, this brings about improvements to the process flow and communications within the logistics activities for the sake of saving materials and ...

  15. Model Testing - Bringing the Ocean into the Laboratory

    DEFF Research Database (Denmark)

    Aage, Christian

    2000-01-01

    Hydrodynamic model testing, the principle of bringing the ocean into the laboratory to study the behaviour of the ocean itself and the response of man-made structures in the ocean in reduced scale, has been known for centuries. Due to an insufficient understanding of the physics involved, however......, the early model tests often gave incomplete or directly misleading results.This keynote lecture deals with some of the possibilities and problems within the field of hydrodynamic and hydraulic model testing....

  16. Drugs Approved for Esophageal Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for esophageal cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  17. Drugs Approved for Liver Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for liver cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  18. Drugs Approved for Kaposi Sarcoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Kaposi sarcoma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  19. Drugs Approved for Pancreatic Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for pancreatic cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  20. Drugs Approved for Vaginal Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) to prevent vaginal cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  1. Drugs Approved for Skin Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for skin cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  2. Drugs Approved for Vulvar Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for vulvar cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  3. Drugs Approved for Wilms Tumor

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Wilms tumor and other childhood kidney cancers. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  4. Drugs Approved for Lung Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for lung cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  5. Drugs Approved for Bone Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for bone cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  6. Drugs Approved for Malignant Mesothelioma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for malignant mesothelioma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  7. Drugs Approved for Penile Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for penile cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  8. Drugs Approved for Bladder Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for bladder cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  9. Drugs Approved for Endometrial Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for endometrial cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  10. Is It Really FDA Approved?

    Science.gov (United States)

    ... satisfaction before companies can market them in interstate commerce. Some examples of biologics that require approval are ... it means the agency has determined that the benefits of the product outweigh the known risks for ...

  11. Electronic Voucher Approval - Financial Management

    Data.gov (United States)

    US Agency for International Development — This process provides a workflow and eSignature capability which allows the CFO to router vouchers for review and electronic signature approval to COTRs in AIDW. It...

  12. Ensuring a successful family business management succession

    OpenAIRE

    Desbois, Joris

    2016-01-01

    Succession is the biggest long-term challenge that most family businesses face. Indeed, leaders ‘disposition to plan for their succession is frequently the key factor defining whether their family business subsists or stops. The research seeks to find out how to manage successfully the business management succession over main principles. This work project aims at researching the key points relevant to almost all family firms, to have a viable succession transition and positioni...

  13. Navy Contracting Analyzing Critical Success Factors and Perceived Impact on Success within an Organization

    OpenAIRE

    Hill, Josh R.; McGraw, Kevin L.

    2012-01-01

    MBA Professional Report Approved for public release, distribution unlimited Critical Success Factors (CSF) are essential ingredients within an organization that are necessary to meet critical mission objectives. Identifying those factors can be a vital asset and assist leadership in achieving successful outcomes in contract management. This report will focus on three major contracting commands within the United States Navy Naval Supply Systems Command, Global Logistics Support (NAVSUP-G...

  14. The approval process for biosimilar erythropoiesis-stimulating agents.

    Science.gov (United States)

    Wish, Jay B

    2014-09-05

    A biosimilar drug or follow-on biologic drug is defined by the Public Health Service Act as a product that is "highly similar to the reference product notwithstanding minor differences in clinically active components and there are no clinically meaningful differences between the biologic product and the reference product in terms of the safety, purity and potency of the product." The advantage of biosimilar drugs is that they are significantly less expensive than the reference products, allowing for increased accessibility and cost savings. Recognizing these advantages, the US Congress passed the Biologics Price Competition and Innovation Act in 2009 as part of health care reform. The Biologics Price Competition and Innovation Act allows sponsors of biosimilar agents to seek approval by showing structural and functional similarity to the reference agent, with the extent of required clinical studies to be determined on the basis of the degree of biosimilarity with the reference product. The goal is to bring biosimilar agents to the market more efficiently while still protecting the safety of the public. The European Union has had such a process in place for a number of years. Two biosimilar epoetin agents have been approved in the European Union since 2007, and their companies are conducting trials to seek approval in the United States, because Amgen's patent protection for epoetin alfa expires in 2014. Trials completed for European Union approval of both agents showed similar efficacy and safety to the reference epoetin alfa. As with all biologics, immunogenicity concerns may persist because of the fragility of the manufacturing process and the worldwide experience with pure red cell aplasia as a result of epoetin therapy. The uptake of biosimilar epoetins after approval in the United States will depend on the balance of cost advantage against safety concerns. Competition in the marketplace will likely decrease the cost of the reference agent as well. Copyright

  15. 76 FR 44003 - Notice of Public Information Collection(s) Being Submitted for Review and Approval to the Office...

    Science.gov (United States)

    2011-07-22

    ... common to both types of roaming. Using the same process allows, but does not require, a party to bring a... Complaints. Form Number: FCC Form 485. Type of Review: Revision of a currently approved collection... documents will cover the collection, maintenance, use, and disposal of all personally identifiable...

  16. Behaviour therapy for obesity treatment considering approved drug therapy

    Directory of Open Access Journals (Sweden)

    Wasem, Jürgen

    2008-05-01

    Full Text Available Introduction: Obesity is a worldwide health problem whose prevalence is on the increase. Many obesity-associated diseases require intensive medical treatment and are the cause of a large proportion of health-related expenditures in Germany. Treatment of obesity includes nutritional, exercise and behaviour therapy, usually in combination. The goal of behaviour therapy for obesity is to bring about a long-term alteration in the eating and exercise habits of overweight and obese individuals. Under certain circumstances, drug treatment may be indicated. Objectives: What is the effectiveness of behaviour therapy for obesity considering approved drugs reduce weight under medical, economic, ethical-social and legal aspects? Methods: A systematic review was conducted using relevant electronic literature databases. Publications chosen according to predefined criteria are evaluated by approved methodical standards of the evidence-based medicine systematically and qualitatively. Results: In total 18 studies, included one HTA and one meta-analysis could be identified according to the predefined inclusion criteria. Three studies compare behaviour therapy to other therapy forms (advice or instruction on nutritional changes, physical activity or a combination of the two, six studies evaluate different forms of behaviour therapy, four studies and four studies compare behaviour therapies mediated by Internet or telephone. Three studies could be identified examining the effect of the combination of behaviour and drug therapy. Furthermore one HTA and one meta-analysis could be included in the evaluation. The behaviour therapy in comparison with other therapy forms reveals a higher effectiveness. In comparison of the different therapeutic approaches of the behaviour therapy intensive behaviour therapy forms and group therapy show a higher effectiveness. Studies related to behaviour therapy based on media support demonstrate a weight reduction both through the

  17. Bringing indigenous ownership back to the private sector

    DEFF Research Database (Denmark)

    Kragelund, Peter

    . This time disguised in terms like empowerment and unequal opportunities but just as politicised as in the 1970s. In light of the current anti-Chinese sentiments in Zambia, this paper seeks to further our understanding of private sector policy making in Zambia. It argues that populist politics, referring...... been particularly present in all sectors of the Zambian economy. Foreign ownership, however, is not new to African societies and several African countries pursued indigenisation policies in the wake of independence to bring ownership back to their own citizens. Now indigenisation policies thrive again...

  18. Bring Your Own Device - Providing Reliable Model of Data Access

    Directory of Open Access Journals (Sweden)

    Stąpór Paweł

    2016-10-01

    Full Text Available The article presents a model of Bring Your Own Device (BYOD as a model network, which provides the user reliable access to network resources. BYOD is a model dynamically developing, which can be applied in many areas. Research network has been launched in order to carry out the test, in which as a service of BYOD model Work Folders service was used. This service allows the user to synchronize files between the device and the server. An access to the network is completed through the wireless communication by the 802.11n standard. Obtained results are shown and analyzed in this article.

  19. Bring Your Own Device in the Information Literacy Classroom

    OpenAIRE

    Stonebraker, Ilana; Robertshaw, M Brooke; Kirkwood, Hal; Dugan, Mary

    2014-01-01

    In the 2013 school year, a team of librarians in the Parrish Library of Management and Economics at Purdue University taught a business information literacy course to approximately 500 management students in eight 70-person sessions. Due to limitations on a set of iPads borrowed from another department, one of two concurrent classes was taught with a set of iPads, while another had a Bring Your Own Device (BYOD) policy, where students brought their own laptops or iPads. Focus groups, observat...

  20. Bringing Space Scientists, Teachers, and Students Together With The CINDI E/PO Program

    Science.gov (United States)

    Urquhart, M.; Hairston, M.

    2007-12-01

    We will report on the activities, challenges, and successes of the ongoing collaboration between the William B. Hanson Center for Space Sciences (CSS) and the Department of Science/Mathematics Education (SME) at the University of Texas at Dallas. At the core of our partnership is the Education and Public Outreach program for the Coupled Ion / Neutral Dynamics Investigation (CINDI) instrument. CINDI is a NASA-funded program on the Air Force's Communication / Navigation Outage Forecast Satellite (C/NOFS) which will be launched in summer 2008. The CSS faculty and research scientists and the SME faculty and students have created a dynamic program that brings scientists and K-12 teachers together. Our activities include middle and high school curriculum development, teachers workshops, graduate course work for teachers, creation of the popular "Cindi in Space" educational comic book, and bringing K-12 teachers and students to work and/or visit with the CINDI scientists. We will present the outcomes of this collaborative effort as well as our recent experience of having a physics teacher from a local high school as our Teacher in Residence at CSS in summer 2007.

  1. Ending the CEO succession crisis.

    Science.gov (United States)

    Charan, Ram

    2005-02-01

    The CEO succession process is broken. Many companies have no meaningful succession plans, and few of the ones that do are happy with them. CEO tenure is shrinking; in fact, two out of five CEOs fail in their first 18 months. It isn't just that more CEOs are being replaced; it's that they're being replaced badly. The problems extend to every aspect of CEO succession: internal development programs, board supervision, and outside recruitment. While many organizations do a decent job of nurturing middle managers, few have set up the comprehensive programs needed to find the half-dozen true CEO candidates out of the thousands of leaders in their midst. Even more damaging is the failure of boards to devote enough attention to succession. Search committee members often have no experience hiring CEOs; lacking guidance, they supply either the narrowest or the most general of requirements and then fail to vet eitherthe candidates or the recruiters. The result is that too often new CEOs are plucked from the well-worn Rolodexes of a remarkably small number of recruiters. These candidates may be strong in charisma but may lack critical skills or otherwise be a bad fit with the company. The resulting high turnover is particularly damaging, since outside CEOs often bring in their own teams, can cause the company to lose focus, and are especially costly to be rid of. Drawing on over 35 years of experience with CEO succession, the author explains how companies can create a deep pool of internal candidates, how boards can consistently align strategy and leadership development, and how directors can get their money's worth from recruiters. Choosing a CEO should be not one decision but an amalgam ofthousands of decisions made by many people every day over years.

  2. A Review of Bring Your Own Device on Security Issues

    Directory of Open Access Journals (Sweden)

    Morufu Olalere

    2015-04-01

    Full Text Available Mobile computing has supplanted internet computing because of the proliferation of cloud-based applications and mobile devices (such as smartphones, palmtops, and tablets. As a result of this, workers bring their mobile devices to the workplace and use them for enterprise work. The policy of allowing the employees to work with their own personal mobile devices is called Bring Your Own Devices (BYOD. In this article, we discuss BYOD’s background, prevalence, benefits, challenges, and possible security attacks. We then review contributions of academic researchers on BYOD. The Universiti Putra Malaysia online databases (such as IEEE Xplore digital library, Elsevier, Springer, ACM digital library were used to search for peer-reviewed academic publications and other relevant publications on BYOD. The Google Scholar search engine was also used. Our thorough review shows that security issues comprise the most significant challenge confronting BYOD policy and that very little has been done to tackle this security challenge. It is our hope that this review will provide a theoretical background for future research and enable researchers to identify researchable areas of BYOD.

  3. Bringing Science to Life for Students, Teachers and the Community

    Science.gov (United States)

    Pratt, K.

    2012-04-01

    Bringing Science to Life for Students, Teachers and the Community Prior to 2008, 5th grade students at two schools of the New Haven Unified School District consistently scored in the bottom 20% of the California State Standards Test for science. Teachers in the upper grades reported not spending enough time teaching science, which is attributed to lack of time, resources or knowledge of science. A proposal was written to the National Oceanic and Atmospheric Administration's Bay Watershed Education Grant program and funding was received for Bringing Science to Life for Students, Teachers and the Community to address these concerns and instill a sense of stewardship in our students. This program engages and energizes students in learning science and the protection of the SF Bay Watershed, provides staff development for teachers, and educates the community about conservation of our local watershed. The project includes a preparation phase, outdoor phase, an analysis and reporting phase, and teacher training and consists of two complete units: 1) The San Francisco Bay Watershed Unit and 2) the Marine Environment Unit. At the end of year 5, our teachers were teaching more science, the community was engaged in conservation of the San Francisco Bay Watershed and most importantly, student scores increased on the California Science Test at one site by over 121% and another site by 152%.

  4. Electronic Approval of Invoices (AEF)

    CERN Multimedia

    2003-01-01

    With a view to the simplification of administrative procedures, AS and FI Divisions have drawn up a new procedure for the electronic approval of invoices via the EDH application. The aim of this new procedure is to rationalise the invoice approval process, notably by eliminating paper copies from the approval circuit. This will simplify the processing of invoices and facilitate their timely settlement, while at the same time maintaining a high level of security. This new procedure, in its current phase, will be gradually implemented from 1 November 2003 onwards. For clarification and further information, please see: http://ais.cern.ch/projs/AEF/help/help.htm . Finance Division, Accounts Payable Tel.: 7.22.95

  5. Bringing the Great American Eclipse of 2017 to Audiences across the Nation

    Science.gov (United States)

    Young, C. A.; Mayo, L.; Cline, T. D.; Ng, C.; Stephenson, B. E.

    2015-12-01

    The August 21, 2017 eclipse across America will be seen by an estimated 500 million people from northern Canada to South America as well as parts of western Europe and Africa. Through This "Great American Eclipse" NASA in partnership with Google, the American Parks Network, American Astronomical Society, the Astronomical League, and numerous other science, education, outreach, and public communications groups and organizations will develop the approaches, resources, partnerships, and technology applications necessary to bring the excitement and the science of the August 21st, 2017 total solar eclipse across America to formal and informal audiences in the US and around the world. This effort will be supported by the highly visible and successful Sun Earth Days program and will be the main theme for Sun-Earth Days 2017.This presentation will discuss NASA's education and communication plans for the eclipse and will detail a number of specific programs and partnerships being leveraged to enhance our reach and impact.

  6. Method of bringing nuclear power plant to fractional electrical load conditions

    International Nuclear Information System (INIS)

    Iljunin, V.G.; Kuznetsoy, I.A.; Murogov, V.M.; Shmelev, A.N.

    1978-01-01

    A method is described of bringing a nuclear power plant to fractional electric load conditions, which power plant comprises at least two nuclear reactors, at least one nuclear reactor being a breeder and both reactors transferring heat to the turbine working substance, consisting in that the consumption of the turbine working substance is reduced in accordance with a predetermined fractional load. At the same time, the amount of heat being transferred from the nuclear reactors to the turbine working substance is reduced, for which purpose the reactors are included in autonomous cooling circuits to successively transfer heat to the turbine working substance. The breeding reactor is included in the cooling circuit with a lower coolant temperature, the temperature of the coolant at the inlet and outlet of the breeder being reduced to a level ensuring the operation of the nuclear power plant in predetermined fractional load conditions, due to which the power of the breeder is increased, and afterheat is removed

  7. Accelerated approval of oncology products: the food and drug administration experience.

    Science.gov (United States)

    Johnson, John R; Ning, Yang-Min; Farrell, Ann; Justice, Robert; Keegan, Patricia; Pazdur, Richard

    2011-04-20

    We reviewed the regulatory history of the accelerated approval process and the US Food and Drug Administration (FDA) experience with accelerated approval of oncology products from its initiation in December 11, 1992, to July 1, 2010. The accelerated approval regulations allowed accelerated approval of products to treat serious or life-threatening diseases based on surrogate endpoints that are reasonably likely to predict clinical benefit. Failure to complete postapproval trials to confirm clinical benefit with due diligence could result in removal of the accelerated approval indication from the market. From December 11, 1992, to July 1, 2010, the FDA granted accelerated approval to 35 oncology products for 47 new indications. Clinical benefit was confirmed in postapproval trials for 26 of the 47 new indications, resulting in conversion to regular approval. The median time between accelerated approval and regular approval of oncology products was 3.9 years (range = 0.8-12.6 years) and the mean time was 4.7 years, representing a substantial time savings in terms of earlier availability of drugs to cancer patients. Three new indications did not show clinical benefit when confirmatory postapproval trials were completed and were subsequently removed from the market or had restricted distribution plans implemented. Confirmatory trials were not completed for 14 new indications. The five longest intervals from receipt of accelerated approval to July 1, 2010, without completion of trials to confirm clinical benefit were 10.5, 6.4, 5.5, 5.5, and 4.7 years. The five longest intervals between accelerated approval and successful conversion to regular approval were 12.6, 9.7, 8.1, 7.5, and 7.4 years. Trials to confirm clinical benefit should be part of the drug development plan and should be in progress at the time of an application seeking accelerated approval to prevent an ineffective drug from remaining on the market for an unacceptable time.

  8. Maturing as a Manager: Bringing Leadership and Management Together

    Science.gov (United States)

    Hay, Susan

    2012-01-01

    Very few people in early years would dispute that the success of a child care centre is almost entirely down to the strength of the centre manager. At its most successful, management expands to leadership, where leaders are able to influence the behaviour of others for the purpose of achieving a goal. Leaders develop a special set of rather…

  9. A successful turnaround in Dade County

    Energy Technology Data Exchange (ETDEWEB)

    Frank, H. (Architecture Montenay Inc., Miami, FL (USA))

    1988-10-01

    When Dade County, Fla., decided to build a waste-to-energy plant, little did it known what a stink it would bring. Odor problems and seagulls plagued the neighborhood, emissions exceeded regulatory standards, and wind-blown garbage littered the facility. Maintenance costs rose and electricity sales never came close to its rated capacity. The residents called for a change, and they got it. After a new operator took over the plant, some of the problems were quickly solved. Other problems, which required substantial capital improvements to solve, were clearly identified. And after Dade County approved a new contract with $45 million in improvements, the facility is back on track to meeting the community's needs in an acceptable manner. The paper describes the original plant design, early problems, improved operation, present plant operation, and the Plant Rehabilitation Program.

  10. Drugs Approved for Cervical Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for cervical cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  11. Drugs Approved for Multiple Myeloma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for multiple myeloma and other plasma cell neoplasms. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  12. Drugs Approved for Testicular Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for testicular cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  13. Drugs Approved for Hodgkin Lymphoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Hodgkin lymphoma. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  14. Drugs Approved for Myeloproliferative Neoplasms

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for myeloproliferative neoplasms. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  15. Bringing history to life: simulating landmark experiments in psychology.

    Science.gov (United States)

    Boynton, David M; Smith, Laurence D

    2006-05-01

    The course in history of psychology can be challenging for students, many of whom enter it with little background in history and faced with unfamiliar names and concepts. The sheer volume of material can encourage passive memorization unless efforts are made to increase student involvement. As part of a trend toward experiential history, historians of science have begun to supplement their lectures with demonstrations of classic physics experiments as a way to bring the history of science to life. Here, the authors report on computer simulations of five landmark experiments from early experimental psychology in the areas of reaction time, span of attention, and apparent motion. The simulations are designed not only to permit hands-on replication of historically important results but also to reproduce the experimental procedures closely enough that students can gain a feel for the nature of early research and the psychological processes being studied.

  16. Mathematical models in biology bringing mathematics to life

    CERN Document Server

    Ferraro, Maria; Guarracino, Mario

    2015-01-01

    This book presents an exciting collection of contributions based on the workshop “Bringing Maths to Life” held October 27-29, 2014 in Naples, Italy.  The state-of-the art research in biology and the statistical and analytical challenges facing huge masses of data collection are treated in this Work. Specific topics explored in depth surround the sessions and special invited sessions of the workshop and include genetic variability via differential expression, molecular dynamics and modeling, complex biological systems viewed from quantitative models, and microscopy images processing, to name several. In depth discussions of the mathematical analysis required to extract insights from complex bodies of biological datasets, to aid development in the field novel algorithms, methods and software tools for genetic variability, molecular dynamics, and complex biological systems are presented in this book. Researchers and graduate students in biology, life science, and mathematics/statistics will find the content...

  17. Archaeopteryx: Bringing the Dino-Bird to Life

    International Nuclear Information System (INIS)

    Bergmann, Uwe

    2011-01-01

    Some 150 million years ago, a strange creature died in a tropical lagoon that today is located in Bavaria, Germany. In 1861, a single feather of this creature was discovered. Not long afterward, a complete fossil was found with the same bird-like feathers but dinosaur-like anatomical features. Darwin had just published 'On the Origin of Species'; could this be the missing link that Darwin's supporters hoped to find? Recently, two of the now eleven discovered Archaeopteryx fossils, and that first feather, were brought to SLAC, where, using the intense X-ray beam, researchers searched for the chemical remains of the original living creatures. Please join us for this lecture, which will explain how the studies attempt to bring the original dino-bird back to life.

  18. Archaeopteryx: Bringing the Dino-Bird to Life

    Energy Technology Data Exchange (ETDEWEB)

    Bergmann, Uwe

    2011-01-25

    Some 150 million years ago, a strange creature died in a tropical lagoon that today is located in Bavaria, Germany. In 1861, a single feather of this creature was discovered. Not long afterward, a complete fossil was found with the same bird-like feathers but dinosaur-like anatomical features. Darwin had just published 'On the Origin of Species'; could this be the missing link that Darwin's supporters hoped to find? Recently, two of the now eleven discovered Archaeopteryx fossils, and that first feather, were brought to SLAC, where, using the intense X-ray beam, researchers searched for the chemical remains of the original living creatures. Please join us for this lecture, which will explain how the studies attempt to bring the original dino-bird back to life.

  19. Dedicated researcher brings cancer care to rural communities

    Directory of Open Access Journals (Sweden)

    Sharan Bhuller

    2016-10-01

    that lack reliable clean water or electricity. It is an incredibly cost-effective option for low-resource countries seeking to develop national cervical cancer screening and treatment programs according to PATH.“Both projects were completed successfully and brought out research conclusions in the form of national and international publications,” Dr. Asthana says. In addition to the projects, she had also developed health education materials to create cervical cancer awareness among the women of rural Indian community, while providing training to auxiliary nurses and midwives for cervical cancer screening.Dr. Asthana graduated with a degree in Bachelor of Medicine and Bachelor of Surgery from King George Medical College (KGMC, Lucknow, Uttar Pradesh, India, before pursuing her Doctor of Medicine (MD in Community Medicine from Ganesh Shankar Vidyarthi Memorial (GSVM Medical College, Kanpur, India.  Throughout her career, she has published over 40 articles in national and international journals. As a result of her hard work and dedication toward the medical field, she has been awarded first prizes for oral presentation in international conferences such as Indian Cancer Congress (ICC 2014 and Asia Oceania Research Organisation on Genital Infections and Neoplasia (AOGIN 2012.She is an active member of various scientific associations and societies such as the Indian Association for Cancer Research (IACR, Indian Society for Medical Statistics (ISMS, Indian Association of Preventive and Social Medicine (IAPSM, and International Epidemiological Association (IEA. In her effort to provide impactful messages via research publications, she is currently working on remodeling the cancer registry data, which includes a diversified field for incidence of childhood cancer, breast and cervical cancer, trends of major cancer, cancer burden in Northeast of India, among other things.According to Dr. Asthana, her vision is the utilization of voluminous cancer registry data to produce

  20. No-till systems on the Chequen Farm in Chile: A success story in bringing practice and science together

    Directory of Open Access Journals (Sweden)

    D. Reicosky

    2014-03-01

    Full Text Available No-till cropping systems provide an opportunity to protect the soil from erosion, while contemporaneously maintaining high yields and contributing to global food security. The historical aspects and the remarkable development of no-till systems on the Chequen Farm in Chile are reviewed. The adoption of no-till over the last 40 years has been a major turning point in reducing the devastating effects of soil erosion and a model for the evolution of sustainable crop production in highly erodible terrain in other parts of the world. The process of adoption of no-till systems in severely eroded foothills of Chile is described, as well as the environmental benefits and the sustainability of the system. The practical aspects of these developments are supported by scientific literature where appropriate, illustrating the value and coincident knowledge gained when combining analogue observations and information with scientific principles.

  1. Educational Attainment: Success to the Successful

    Science.gov (United States)

    Anthony, Peter; Gould, David; Smith, Gina

    2013-01-01

    Systems archetypes are patterns of structure found in systems that are helpful in understanding some of the dynamics within them. The intent of this study was to examine educational attainment data using the success-to-the-successful archetype as a model to see if it helps to explain the inequality observed in the data. Data covering 1990 to 2009…

  2. College Success Courses: Success for All

    Science.gov (United States)

    Coleman, Sandra Lee; Skidmore, Susan Troncoso; Weller, Carol Thornton

    2018-01-01

    College success courses (CSCs), or orientation courses, are offered by community colleges and universities to facilitate the success of first-time-in-college students. Primarily, these courses are designed to address students' nonacademic deficiencies, such as weak study habits and poor organizational skills, and to familiarize students with…

  3. Issues for Bringing Electron Beam Irradiators On-Line

    International Nuclear Information System (INIS)

    Kaye, R.J.; Turman, B.N.

    1999-01-01

    Irradiation of red meat and poultry has been approved by the U.S. FDA, and the U.S. Department of Agriculture's rule for processing red meat is out for comment. Looking beyond the current issues of packaging materials, labeling, and consumer acceptance, this paper reviews the next step of implementation and how to remove, or at least reduce, the barriers to utilization. Polls of the user community identified their requirements for electron beam or x-ray processing of meat or poultry and their concerns about implementation for on-line processing. These needs and issues are compared to the capabilities of the accelerator industry. The critical issues of beam utilization and dose uniformity, factors affecting floor space requirements, and treatment costs are examined

  4. Issues for Bringing Electron Beam Irradiators On-Line

    Energy Technology Data Exchange (ETDEWEB)

    Kaye, R.J.; Turman, B.N.

    1999-04-20

    Irradiation of red meat and poultry has been approved by the U.S. FDA, and the U.S. Department of Agriculture's rule for processing red meat is out for comment. Looking beyond the current issues of packaging materials, labeling, and consumer acceptance, this paper reviews the next step of implementation and how to remove, or at least reduce, the barriers to utilization. Polls of the user community identified their requirements for electron beam or x-ray processing of meat or poultry and their concerns about implementation for on-line processing. These needs and issues are compared to the capabilities of the accelerator industry. The critical issues of beam utilization and dose uniformity, factors affecting floor space requirements, and treatment costs are examined.

  5. 78 FR 76310 - Agency Information Collection Activities: Submission to OMB for Review and Approval; Public...

    Science.gov (United States)

    2013-12-17

    ... collection will also provide information on CHWs' efforts to enroll clients and the successes and failures... forms; and 3. Client satisfaction surveys. ORHP is seeking approval from OMB for the three methods of... designed to gather information on successes and challenges associated with the program design and...

  6. Immunotherapy Combination Approved for Advanced Kidney Cancer

    Science.gov (United States)

    FDA has approved the combination of the immunotherapy drugs nivolumab (Opdivo) and ipilimumab (Yervoy) as an initial treatment for some patients with advanced kidney cancer. The approval is expected to immediately affect patient care, as this Cancer Currents post explains.

  7. Attitudes of Success.

    Science.gov (United States)

    Pendarvis, Faye

    This document investigates the attitudes of successful individuals, citing the achievement of established goals as the criteria for success. After offering various definitions of success, the paper focuses on the importance of self-esteem to success and considers ways by which the self-esteem of students can be improved. Theories of human behavior…

  8. Creating School Cultures that Embrace Learning: What Successful Leaders Do

    Science.gov (United States)

    Thacker, Tony; Bell, John S.; Schargel, Franklin P.

    2009-01-01

    This book brings together the insight and experience of successful leaders from over 60 schools on the issue of improving school culture--in their very own words. It provides the tools, practices, and examples that will help you in your own effort to improve school culture. Contents include: Acknowledgments; Acknowledgment of Contributing Schools;…

  9. Successful Practices for Immigrant Parent Involvement: An Ontario Perspective

    Science.gov (United States)

    Ladky, Mary; Peterson, Shelley Stagg

    2008-01-01

    This article brings together the perspectives of 21 immigrant parents who speak eight different languages and have been in Canada less than six years with those of 61 teachers and 32 principals who work in schools with English as a second language (ESL) populations of 20% or greater who have been recognized for successfully involving immigrant…

  10. Features of Home Environments Associated with Children's School Success.

    Science.gov (United States)

    Martini, Mary

    1995-01-01

    Examines middle-class child-rearing philosophies and practices and their effect on children's academic success. Suggests that middle-class parenting practices reflect a coherent set of cultural beliefs about the relation of the individual to the group and about the parents' role in bringing children into the group. Suggests that these beliefs…

  11. 40 CFR 145.31 - Approval process.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Approval process. 145.31 Section 145.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE UIC PROGRAM REQUIREMENTS Program Approval, Revision and Withdrawal § 145.31 Approval process. (a...

  12. 40 CFR 123.61 - Approval process.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Approval process. 123.61 Section 123... REQUIREMENTS Program Approval, Revision, and Withdrawal § 123.61 Approval process. (a) After determining that a...; and (6) Briefly outline the fundamental aspects of the State's proposed program, and the process for...

  13. 7 CFR 1710.406 - Loan approval.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Loan approval. 1710.406 Section 1710.406 Agriculture... GENERAL AND PRE-LOAN POLICIES AND PROCEDURES COMMON TO ELECTRIC LOANS AND GUARANTEES Application Requirements and Procedures for Loans § 1710.406 Loan approval. (a) A loan is approved when the Administrator...

  14. 40 CFR 52.1772 - Approval status.

    Science.gov (United States)

    2010-07-01

    ...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) North Carolina § 52.1772 Approval status. (a) With the exceptions set forth in this subpart, the Administrator approves North Carolina's plans for... CTGs issued by the previous January. (b) New Source review permits issued pursuant to section 173 of...

  15. 40 CFR 52.2122 - Approval status.

    Science.gov (United States)

    2010-07-01

    ... sources covered by CTGs issued by the previous January. (b) EPA disapproved South Carolina's generic...) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) South Carolina § 52.2122 Approval status. (a) With the exceptions set forth in this subpart, the Administrator approves South Carolina's plans for...

  16. 40 CFR 52.1323 - Approval status.

    Science.gov (United States)

    2010-07-01

    ... on January 16, 1979 (44 FR 3274) are met. (b) The Administrator approves Rule 10 CSR 10-2.290 as.... (c) The Administrator approves Rule 10 CSR 10-2.230 as identified under § 52.1320, paragraph (c)(70... SIP would be the emission limits stated in the rule. (d) The Administrator approves Rule 10 CSR 10-5...

  17. 9 CFR 147.52 - Approved tests.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Approved tests. 147.52 Section 147.52 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Approved Tests § 147.52 Approved tests. (a) The procedures for the bacteriological examination of poultry...

  18. Supporting Success for All Students

    Science.gov (United States)

    Manduca, C. A.; Macdonald, H.; McDaris, J. R.; Weissmann, G. S.

    2015-12-01

    The geoscience student population in the United States today does not reflect the diversity of the US population. Not only does this challenge our ability to educate sufficient numbers of students in the geosciences, it also challenges our ability to address issues of environmental justice, to bring geoscience expertise to diverse communities, and to pursue a research agenda reflecting the needs and interests of our nation as a whole. Programs that are successful in supporting students from underrepresented groups attend to the whole student (Jolly et al, 2004) as they develop not only knowledge and skills, but a sense of belonging and a drive to succeed in geoscience. The whole student approach provides a framework for supporting the success of all students, be they members of underrepresented groups or not. Important aspects of support include mentoring and advising, academic support, an inclusive learning community, and opportunities to learn about the profession and to develop geoscience and professional skills. To successfully provide support for the full range of students, it is critical to consider not only what opportunities are available but the barriers different types of students face in accessing these opportunities. Barriers may arise from gaps in academic experiences, crossing into a new and unfamiliar culture, lack of confidence, stereotype threat, implicit bias and other sources. Isolation of geoscience learning from its application and social context may preferentially discourage some groups. Action can be taken to increase support for all students within an individual course, a department or an institution. The InTeGrate STEP Center for the Geosciences, the Supporting and Advancing Geoscience Education at Two-Year Colleges program and the On the Cutting Edge Professional Development for Geoscience Faculty program all provide resources for individuals and departments including on line information, program descriptions, and workshop opportunities.

  19. Bringing nanomedicines to market: regulatory challenges, opportunities, and uncertainties.

    Science.gov (United States)

    Nijhara, Ruchika; Balakrishnan, Krishna

    2006-06-01

    Scientists and entrepreneurs who contemplate developing nanomedicine products face several unique challenges in addition to many of the traditional hurdles of product development. In this review we analyze the major physicochemical, biologic and functional characteristics of several nanomedicine products on the market and explore the question of what made them unique. What made them successful? We also focus on the regulatory challenges faced by nanomedicine product developers. Based on these analyses, we propose the factors that are most likely to contribute to the success of nanomedicine products.

  20. 38 CFR 17.65 - Approvals and provisional approvals of community residential care facilities.

    Science.gov (United States)

    2010-07-01

    ... approvals of community residential care facilities. 17.65 Section 17.65 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Community Residential Care § 17.65 Approvals and provisional approvals of community residential care facilities. (a) An approval of a facility meeting all of...

  1. Disulfide Bridges: Bringing Together Frustrated Structure in a Bioactive Peptide.

    Science.gov (United States)

    Zhang, Yi; Schulten, Klaus; Gruebele, Martin; Bansal, Paramjit S; Wilson, David; Daly, Norelle L

    2016-04-26

    Disulfide bridges are commonly found covalent bonds that are usually believed to maintain structural stability of proteins. Here, we investigate the influence of disulfide bridges on protein dynamics through molecular dynamics simulations on the cysteine-rich trypsin inhibitor MCoTI-II with three disulfide bridges. Correlation analysis of the reduced cyclic peptide shows that two of the three disulfide distances (Cys(11)-Cys(23) and Cys(17)-Cys(29)) are anticorrelated within ∼1 μs of bridge formation or dissolution: when the peptide is in nativelike structures and one of the distances shortens to allow bond formation, the other tends to lengthen. Simulations over longer timescales, when the denatured state is less structured, do not show the anticorrelation. We propose that the native state contains structural elements that frustrate one another's folding, and that the two bridges are critical for snapping the frustrated native structure into place. In contrast, the Cys(4)-Cys(21) bridge is predicted to form together with either of the other two bridges. Indeed, experimental chromatography and nuclear magnetic resonance data show that an engineered peptide with the Cys(4)-Cys(21) bridge deleted can still fold into its near-native structure even in its noncyclic form, confirming the lesser role of the Cys(4)-Cys(21) bridge. The results highlight the importance of disulfide bridges in a small bioactive peptide to bring together frustrated structure in addition to maintaining protein structural stability. Copyright © 2016 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  2. Bringing Classroom-Based Assessment into the EFL classroom

    Directory of Open Access Journals (Sweden)

    Andrew Finch

    2012-01-01

    Full Text Available   This paper describes how English as a Foreign Language (EFL teachers can bring reliable, valid, user-friendly assessment into their classrooms, and thus improve the quality of learning that occurs there. Based on the experience of the author as a an EFL teacher and teacher-trainer, it is suggested that the promotion and development of autonomy, intrinsic motivation, and self-esteem that takes place in a Classroom-Based Assessment (CBA environment facilitates an holistic approach to language learning and prepares the students for the high-stakes tests that often determine their motivation for learning English. Rather than relying on the memorization of language code, form, lexis, and prepared answers, students who have learned in a CBA environment are able to self-assess, peer-assess, build portfolios, and edit their own work. Not only does this reduce the assessment burden on the teacher, but it also develops the skills of problem-solving, critical thinking, and summarization in the students, in addition to a heightened awareness of the language-learning process. By learning how to set goals, assess their achievements, and reflect on their future learning needs, students become more efficient language learners. While acknowledging the place of standardized, summative tests in contemporary society, it is suggested that CBA in the EFL classroom can enhance long-term learning and consequently enable and empower students to prepare for their future learning needs.

  3. Bringing gender sensitivity into healthcare practice: a systematic review.

    Science.gov (United States)

    Celik, Halime; Lagro-Janssen, Toine A L M; Widdershoven, Guy G A M; Abma, Tineke A

    2011-08-01

    Despite the body of literature on gender dimensions and disparities between the sexes in health, practical improvements will not be realized effectively as long as we lack an overview of the ways how to implement these ideas. This systematic review provides a content analysis of literature on the implementation of gender sensitivity in health care. Literature was identified from CINAHL, PsycINFO, Medline, EBSCO and Cochrane (1998-2008) and the reference lists of relevant articles. The quality and relevance of 752 articles were assessed and finally 11 original studies were included. Our results demonstrate that the implementation of gender sensitivity includes tailoring opportunities and barriers related to the professional, organizational and the policy level. As gender disparities are embedded in healthcare, a multiple track approach to implement gender sensitivity is needed to change gendered healthcare systems. Conventional approaches, taking into account one barrier and/or opportunity, fail to prevent gender inequality in health care. For gender-sensitive health care we need to change systems and structures, but also to enhance understanding, raise awareness and develop skills among health professionals. To bring gender sensitivity into healthcare practice, interventions should address a range of factors. Copyright © 2010. Published by Elsevier Ireland Ltd.

  4. Bringing the Science of JWST to the Public

    Science.gov (United States)

    Green, Joel D.; Smith, Denise A.; Lawton, Brandon L.; Meinke, Bonnie K.; Jirdeh, Hussein

    2017-01-01

    The James Webb Space Telescope is the successor to the Hubble Space Telescope. STScI and the Office of Public Outreach are committed to bringing awareness of the technology, the excitement, and the future science potential of this great observatory to the public and to the scientific community, prior to its 2018 launch. The challenges in ensuring the high profile of JWST (understanding the infrared, the vast distance to the telescope's final position, and the unfamiliar science territory) requires us to lay the proper background, particularly in the area of spectroscopy. We currently engage the full range of the public and scientific communities using a variety of high impact, memorable initiatives, in combination with modern technologies to extend reach, linking the science goals of Webb to the ongoing discoveries being made by Hubble. Webbtelescope.org, the public hub for scientific information related to JWST, is now open. We have injected Webb-specific content into ongoing outreach programs: for example, partnering with high impact science communicators such as MinutePhysics to produce timely and concise content; partnering with musicians and artists to link science and art. Augmented reality apps showcase NASA’s telescopes in a format usable by anyone with a smartphone, and visuals from increasingly affordable 3D VR technologies.

  5. Does shaping bring an advantage for reversed field pinch plasmas?

    International Nuclear Information System (INIS)

    Guo, S.C.; Xu, X.Y.; Wang, Z.R.; Liu, Y.Q.

    2013-01-01

    The MHD–kinetic hybrid toroidal stability code MARS-K (Liu et al 2008 Phys. Plasmas 15 112503) is applied to study the shaping effects on magnetohydrodynamic (MHD) stabilities in reversed field pinch (RFP) plasmas, where both elongation and triangularity are taken into account. The ideal wall β (the ratio of the gaso-kinetic to magnetic pressures) limit set by the ideal kink mode/resistive wall mode in shaped RFP is investigated first, followed by a study of the kinetic damping on the resistive wall mode. Physics understanding of the results is provided by a systematic numerical analysis. Furthermore, the stability boundary of the linear resistive tearing mode in shaped RFP plasmas is computed and compared with that of the circular case. Finally, bootstrap currents are calculated for both circular and shaped RFP plasmas. Overall, the results of these studies indicate that the current circular cross-section is an appropriate choice for RFP devices, in the sense that the plasma shaping does not bring an appreciable advantage to the RFP performance in terms of macroscopic stabilities. In order to reach a steady-state operation, future RFP fusion reactors will probably need a substantial fraction of external current drives, due to the unfavourable scaling for the plasma-generated bootstrap current in the RFP configuration. (paper)

  6. Demarketing fear: Bring the nuclear issue back to rational discourse

    International Nuclear Information System (INIS)

    Han, Charles C.

    2014-01-01

    This paper attempts to explore the strategies for breaking the deadlock between the demand for resolving climate crisis and the resistance to deploying nuclear power. Since our present renewable technology is not advanced enough to replace fossil fuel power plants, nuclear power becomes the only available means that can buy us more time to explore better energy sources for coping with the dilemma of global warming and energy security. Therefore, this paper proposes an elaborated fear appeal framework that may shed light on the intervention points for mitigating fear. By examining the influence of fear appeal on the nuclear issue, three strategies for demarketing the nuclear fear of the public are recommended. The paper concludes that only when energy policy makers and the nuclear industry recognize the significance of minimizing fear and begin to work on removing the sources of fear, can we then expect to bring the nuclear issue back to rational discourse. - Highlights: • Both cognition and emotion are critical in decision-making processes. • Dealing with the emotion of fear is essential for resolving the nuclear issue. • Fear should be mitigated to make rational discourses on nuclear power happen. • Fear can be mitigated by manipulating issue familiarity and response feasibility. • Using equivalency and issue framing may alter public perceptions of nuclear power

  7. Genes and plays: bringing ELSI issues to life.

    Science.gov (United States)

    Rothenberg, Karen H; Bush, Lynn W

    2012-02-01

    Ethical complexities surround the promise of genomic technology and the power of genetic information as they alter conceptions of identity and dynamics within personal and professional relationships. Creative approaches such as dramatic vignettes offer a unique analytical stage for imagining the bioethical past and future. Dramatic narratives can bring to life images of differing perspectives and values when experiencing innovations in medicine. Although the scientific landscape shifts, concerns expressed in theatre from 50 years ago parallel many contemporary ELSI (ethical, legal, and social implications) issues, highlighting the ongoing struggle to appreciate the impact of emerging genetic technologies on relationships. To illuminate these enduring concerns, we explore how perceptions and relationships have influenced-and been influenced by-genetics as portrayed through dramatic vignettes. We build on the legacy of using case vignettes as a clinical teaching modality, and believe similar value exists within the research ethics domain. The selection of dialogue discussed encompasses abbreviated excerpts from two existing and one original vignette that we staged at the ELSI 2011 Congress and various academic and health institutions.

  8. Frontier Fields: Bringing the Distant Universe into View

    Science.gov (United States)

    Eisenhamer, Bonnie; Lawton, Brandon L.; Summers, Frank; Ryer, Holly

    2014-06-01

    The Frontier Fields is a multi-cycle program of six deep-field observations of strong-lensing galaxy clusters that will be taken in parallel with six deep “blank fields.” The three-year long collaborative program centers on observations from NASA’s Great Observatories, who will team up to look deeper into the universe than ever before, and potentially uncover galaxies that are as much as 100 times fainter than what the telescopes can typically see. Because of the unprecedented views of the universe that will be achieved, the Frontier Fields science program is ideal for informing audiences about scientific advances and topics in STEM. For example, the program provides an opportunity to look back on the history of deep field observations and how they changed (and continue to change) astronomy, while exploring the ways astronomers approach big science problems. As a result, the Space Telescope Science Institute’s Office of Public Outreach has initiated an education and public outreach (E/PO) project to follow the progress of the Frontier Fields program - providing a behind-the-scenes perspective of this observing initiative. This poster will highlight the goals of the Frontier Fields E/PO project and the cost-effective approach being used to bring the program’s results to both the public and educational audiences.

  9. Bringing Western-standard service stations to the Baltic countries

    International Nuclear Information System (INIS)

    Pesonen, H.

    1992-01-01

    Neste is the only Western oil company so far to have established a service station presence in the Baltic, with the exception of Norway's Statoil, which has one outlet near Tallinn Airport. Neste has an important logistical advantage compared to other companies in this respect as its two Finnish refineries are ideally located for supplying the region with high-quality petroleum products. Neste's first joint venture in the Baltic, Traffic Service, based in Estonia, was set up with Eesti Kutus in 1988 and opened its first service station in 1990. Other joint ventures are now up and running in Latvia, Lithuania, Poland, and St. Petersburg. A total of 10 - 15 stations, the majority strategically located along the route of the Via Baltica, are expected to be operational by the end of this year. The Neste network comprises a combination of new outlets and refurbished older stations that have been modernized to bring them up to Western standards. These offer a comprehensive range of fuels, lubricants, spare parts, and accessories, as well as food, confectionery, and coffee shop services. Some stations also offer repair and car wash facilities. Adapting to the transition from a communist economy to a Western, capitalist one has not been easy for the Baltic countries, and has inevitably created difficulties for companies like Neste, in areas such as legislation covering land ownership. Neste's joint ventures have also encountered difficulties in instilling the Western approach to business efficiency, and customer service in a workforce used to the Soviet retail system

  10. Bringing liraglutide to market: a CER case study.

    Science.gov (United States)

    Oderda, Gary; Sifford-Wilson, S Monet

    2012-06-01

    Faced with competition from other drugs and therapies, drug manufacturers may be able to use comparative effectiveness research (CER) to help reduce barriers to a new drug's adoption and integration into formularies. But few examples exist to show how CER can be used effectively and whether the data can make a difference. To examine how CER can help strengthen a new drug's entry into the market and integration into formularies, and how ongoing CER might be valuable as a drug is implemented in the real world. A roundtable of 9 representatives from health plans, including formulary decision makers, evaluated how CER in phase 3 development of a new drug can add to the drug's strength of evidence, helping decision makers understand how and where to integrate that drug into a formulary. The round table participants viewed, as a case study, the development of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist for adults with type 2 diabetes that was approved by the FDA in January 2010. With this drug, CER was incorporated into an extensive type 2 diabetes clinical development program, comparing how the drug worked in comparison with other established therapies. Although there are many antidiabetic drugs available for use, patients with type 2 diabetes often need additional agents. The FDA approved liraglutide with the conclusion that benefits of the drug outweighed potential risks but noted the association with pancreatitis in humans and animal data that showed rare medullary thyroid cancer associated with liraglutide. Roundtable participants agreed that while pre-launch CER can be valuable, ongoing real-world research is also important for confirming expected results, identifying additional uses and indications and managing risks. The participants also suggested opportunities for additional CER studies and made recommendations for manufacturers. Roundtable thought leaders agreed that well-planned trial designs incorporating CER result in high

  11. Companion diagnostics: a regulatory perspective from the last 5 years of molecular companion diagnostic approvals.

    Science.gov (United States)

    Roscoe, Donna M; Hu, Yun-Fu; Philip, Reena

    2015-01-01

    Companion diagnostics are essential for the safe and effective use of the corresponding therapeutic products. The US FDA has approved a number of companion diagnostics used to select cancer patients for treatment with contemporaneously approved novel therapeutics. The processes of co-development and co-approval of a therapeutic product and its companion diagnostic have been a learning experience that continues to evolve. Using several companion diagnostics as examples, this article describes the challenges associated with the scientific, clinical and regulatory hurdles faced by FDA and industry alike. Taken together, this discussion is intended to assist manufacturers toward a successful companion diagnostics development plan.

  12. What Change Can The New Developments In Energy Sector Bring Into the World`s Energypolitical and Geopolitical Order?

    Directory of Open Access Journals (Sweden)

    Onur TUTULMAZ

    2014-12-01

    Full Text Available The recent developments bring US to a leading natural gas and oil producer position. The attempts in last 20 years to bring new horizontal drilling and hydraulic fracturing technologies together have developed a success in shale gas and oil production in US; the production volumes has reached to a position to redefine the market. Last estimations are bringing more information about the shale capacities of the major basins of the world. However, the estimates are based on a wide range of assumptions and consequently their results vary in a large scale. In any case, these developments have crucial economic, political and geopolitical consequences on the energy market, petroleum producer and consumer countries and regions. Despite the wide range of ambiguity of the estimated size of the resources, the estimations show US and North America has one of the biggest potential, already turning technology into the giant production numbers. Some of the estimations allege so big numbers can even mean to a new world order. The asymmetric nature of the potential, can also be said, increases some of the expected impacts too. In this study, basically, we want to supply an initial solid and economical evaluation to this ambiguity. We are trying to shape a frame for the new energy potential and to put it in a place in the current practice of the world. Secondly, in this context, we are underlying here some of the possible economic and geopolitical consequences each of which can constitute a subject of deeper study.

  13. Emergency contraceptives bring a little peace of mind.

    Science.gov (United States)

    Setty, V

    1999-04-01

    Although emergency contraceptive pills have been prescribed to US women since the discovery of the birth control pill, this regimen has been termed "America's best-kept secret." For fear of legal liability, many providers have been unwilling to prescribe oral contraceptive pills for a purpose other than that for which they are labeled on the packaging. There are indications, however, that access to emergency contraception in the US is improving. PREVEN, the first product to be approved by the US Food and Drug Administration specifically for emergency contraception, was released in 1998. The kit includes a step-by-step information booklet, a pregnancy test, and four birth control pills. In Washington State, collaborative drug agreements between volunteer pharmacists and licensed prescribers enable pharmacists to prescribe emergency contraception pills directly--a move that is estimated to have prevented 207 unintended pregnancies and 103 abortions in less than one year. Planned Parenthood has developed two programs to increase the use of emergency contraception. The first allows clinicians to discuss emergency contraception over the phone with clients (even new ones) and to call in prescriptions to local pharmacies; the second provides women with emergency contraceptive kits to keep on hand in advance of a need for the regimen.

  14. Wind Energy Solutions : to bring renewable energy everywhere

    International Nuclear Information System (INIS)

    Baigent, K.

    2006-01-01

    This presentation provided details of Wind Energy Solutions (WES) Canada's current activities and research innovations. Established initially in Holland in 2004, WES Canada's corporate activities include technology development; licensing, registration and approvals; product development; manufacturing and distribution; and global service and maintenance training. WES Canada is the exclusive importer of WES turbines for Canada and the United States, and offers turnkey wind energy solutions for local dealers and installers. WES product technology aims to provide flexible logistics, as well as to facilitate local production and project development. WES turbines range from 2.5 kW to 250 KW and are available for both on-site power generation and grid-connected applications. The presentation provided specifications for the WES 5 Tulipo wind turbine, a low noise level, low vibration turbine that provides 2 independent safety systems: a failsafe brake on fast shaft of gear; and emergency yawing. A series of photographs demonstrated the installation process of the Tulipo. It was noted that many WES turbines are used in farming applications, as the turbine fits easily on 1 truck, and is easy to install with a foundation made by a local contractor using WES technical drawings engineered for local soil conditions. The turbine is also suitable for factories, harbours, schools and remote villages. It was concluded that the turbines have been specifically engineered for cold climates, as an imbalance control will prevent operation when the blades have significant ice build-up. refs., tabs., figs

  15. REVIEW OF NRC APPROVED DIGITAL CONTROL SYSTEMS ANALYSIS

    International Nuclear Information System (INIS)

    Markman, D.W.

    1999-01-01

    Preliminary design concepts for the proposed Subsurface Repository at Yucca Mountain indicate extensive reliance on modern, computer-based, digital control technologies. The purpose of this analysis is to investigate the degree to which the U. S. Nuclear Regulatory Commission (NRC) has accepted and approved the use of digital control technology for safety-related applications within the nuclear power industry. This analysis reviews cases of existing digitally-based control systems that have been approved by the NRC. These cases can serve as precedence for using similar types of digitally-based control technologies within the Subsurface Repository. While it is anticipated that the Yucca Mountain Project (YMP) will not contain control systems as complex as those required for a nuclear power plant, the review of these existing NRC approved applications will provide the YMP with valuable insight into the NRCs review process and design expectations for safety-related digital control systems. According to the YMP Compliance Program Guidance, portions of various NUREGS, Regulatory Guidelines, and nuclear IEEE standards the nuclear power plant safety related concept would be applied to some of the designs on a case-by-case basis. This analysis will consider key design methods, capabilities, successes, and important limitations or problems of selected control systems that have been approved for use in the Nuclear Power industry. An additional purpose of this analysis is to provide background information in support of further development of design criteria for the YMP. The scope and primary objectives of this analysis are to: (1) Identify and research the extent and precedence of digital control and remotely operated systems approved by the NRC for the nuclear power industry. Help provide a basis for using and relying on digital technologies for nuclear related safety critical applications. (2) Identify the basic control architecture and methods of key digital control

  16. Who's bringing you hot ideas and how are you responding?

    Science.gov (United States)

    Davenport, Thomas H; Prusak, Laurence; Wilson, H James

    2003-02-01

    There's an unsung hero in your organization. It's the person who's bringing in new ideas from the outside about how to manage better. These aren't your product and service innovators--those people are celebrated loudly and often. This is the manager who, for instance, first uttered the phrase "balance scorecard" in your hallways, or "real options," or "intellectual capital." Managerial innovation is an increasingly important source of competitive advantage--especially given the speed with which product innovations are copied--but it doesn't happen automatically. It takes a certain kind of person to welcome new management ideas and usher them into an organization. The authors recently studied 100 such people to find out how they translate new ideas into action in their organizations. They discovered that they are a distinct type of practitioner; that is to say, they resemble their counterparts in other organizations more than they resemble their own colleagues, and they share a common way of working. "Idea practitioners," as the authors call them, begin by scouting for ideas. All of them are avid readers of management literature and enthusiastic participants in business conferences; many are friendly with business gurus. Once they've identified an idea that seems to hold promise, they tailor it to fit their organizations' specific needs. Next, they actively sell the idea--to senior executives, to the rank and file, to middle managers. And finally, they get the ball rolling by participating in small-scale experiments. But when those take off, they get out of the way and let others execute. In this article, the authors identify the characteristics of idea practitioners and offer strategies for managing them wisely.

  17. Underworld - Bringing a Research Code to the Classroom

    Science.gov (United States)

    Moresi, L. N.; Mansour, J.; Giordani, J.; Farrington, R.; Kaluza, O.; Quenette, S.; Woodcock, R.; Squire, G.

    2017-12-01

    While there are many reasons to celebrate the passing of punch card programming and flickering green screens,the loss of the sense of wonder at the very existence of computers and the calculations they make possible shouldnot be numbered among them. Computers have become so familiar that students are often unaware that formal and careful design of algorithms andtheir implementations remains a valuable and important skill that has to be learned and practiced to achieveexpertise and genuine understanding. In teaching geodynamics and geophysics at undergraduate level, we aimed to be able to bring our researchtools into the classroom - even when those tools are advanced, parallel research codes that we typically deploy on hundredsor thousands of processors, and we wanted to teach not just the physical concepts that are modelled by these codes but asense of familiarity with computational modelling and the ability to discriminate a reliable model from a poor one. The underworld code (www.underworldcode.org) was developed for modelling plate-scale fluid mechanics and studyingproblems in lithosphere dynamics. Though specialised for this task, underworld has a straightforwardpython user interface that allows it to run within the environment of jupyter notebooks on a laptop (at modest resolution, of course).The python interface was developed for adaptability in addressing new research problems, but also lends itself to integration intoa python-driven learning environment. To manage the heavy demands of installing and running underworld in a teaching laboratory, we have developed a workflow in whichwe install docker containers in the cloud which support a number of students to run their own environment independently. We share ourexperience blending notebooks and static webpages into a single web environment, and we explain how we designed our graphics andanalysis tools to allow notebook "scripts" to be queued and run on a supercomputer.

  18. Imaginative ethics--bringing ethical praxis into sharper relief.

    Science.gov (United States)

    Hansson, Mats G

    2002-01-01

    The empirical basis for this article is three years of experience with ethical rounds at Uppsala University Hospital. Three standard approaches of ethical reasoning are examined as potential explanations of what actually occurs during the ethical rounds. For reasons given, these are not found to be satisfying explanations. An approach called "imaginative ethics", is suggested as a more satisfactory account of this kind of ethical reasoning. The participants in the ethical rounds seem to draw on a kind of moral competence based on personal life experience and professional competence and experience. By listening to other perspectives and other experiences related to one particular patient story, the participants imagine alternative horizons of moral experience and explore a multitude of values related to clinical practice that might be at stake. In his systematic treatment of aesthetics in the Critique of Judgement, Kant made use of an operation of thought that, if applied to ethics, will enable us to be more sensitive to the particulars of each moral situation. Based on this reading of Kant, an account of imaginative ethics is developed in order to bring the ethical praxis of doctors and nurses into sharper relief. The Hebraic and the Hellenic traditions of imagination are used in order to illuminate some of the experiences of ethical rounds. In conclusion, it is argued that imaginative ethics and principle-based ethics should be seen as complementary in order to endow a moral discourse with ethical authority. Kantian ethics will do the job if it is remembered that Kant suggested only a modest, negative role of principle-based deliberation.

  19. Success in Science, Success in Collaboration

    Energy Technology Data Exchange (ETDEWEB)

    Johnston, Mariann R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-08-25

    This is a series of four different scientific problems which were resolved through collaborations. They are: "Better flow cytometry through novel focusing technology", "Take Off®: Helping the Agriculture Industry Improve the Viability of Sustainable, Large-Production Crops", "The National Institutes of Health's Models of Infectious Disease Agent Study (MIDAS)", and "Expanding the capabilities of SOLVE/RESOLVE through the PHENIX Consortium." For each one, the problem is listed, the solution, advantages, bottom line, then information about the collaboration including: developing the technology, initial success, and continued success.

  20. 30 CFR 14.7 - Approval marking and distribution records.

    Science.gov (United States)

    2010-07-01

    ..., EVALUATION, AND APPROVAL OF MINING PRODUCTS REQUIREMENTS FOR THE APPROVAL OF FLAME-RESISTANT CONVEYOR BELTS General Provisions § 14.7 Approval marking and distribution records. (a) An approved conveyor belt must be marketed only under the name specified in the approval. (b) Approved conveyor belt must be legibly and...

  1. Approval of radioactive consumer goods

    International Nuclear Information System (INIS)

    Paynter, R.A.

    1992-01-01

    The 1980 Euratom Directive obliges the UK to draw up a system of prior authorization for the use of radioactive substances in a range of consumer products, and the Government intends to make regulations to fulfil the requirements of the Directive. These regulations will empower NRPB to approve such products prior to their supply to the public. In this brief article, the NRPB reviews the criteria against which to consider any proposed use of radioactive substances, considers radiological production standards for products and discusses the questions of the labelling of radioactive consumer goods. (UK)

  2. The Project of Success

    DEFF Research Database (Denmark)

    Kreiner, Kristian

    more complicated matter than meeting targets. While success may ultimately be justified in terms of a correspondence between aims and achievements, the understanding of both aspects is highly dependent on the project process. An example of a successful project that did not meet the original performance...... targets will serve to show that success is at matter of perspective as much as it is a matter of achievement. Other types of research, e.g. social psychology, have addressed the issue of success more explicitly. I draw on such literature to conceptualize project success anew and to reestablish...

  3. Kaiserschnitten Wien - Let's bring the forest in the city

    Directory of Open Access Journals (Sweden)

    Ajda Primožič

    2012-01-01

    Full Text Available The location is part of the Vienna River Valley, known as "Wiental", one of the most dissonant, incongruous, and contested areas of Vienna. Depending on one’s perspective, the Vienna River Valley can be viewed as a transit corridor, an unresolved urban area, an urban interface, an inter- zone, an infrastructure bundle, an ugly wound in the urban landscape, a socially charged boundary, etc. We started the project with urban pattern analyses on different scales: the scale of the city, the scale of Wiental (from Schönbrunn to Hofburg and on a minor scale, i.e. the scale of the project.The analysis showed that Wiental constitutes the main connection between the city centre and suburbia and the countryside in the background of the city. With its clear morphological importance, it could become a green axis of the city, a pleasant place for people, rather than having only an infrastructural role. Our concept is to bring new character to Wiental by making it a pedestrian- and cyclist-friendly green axis. Our initial goal was to reduce car traffic. We proposed introducing a park-and-ride system, which would become a point of transfer where car traffic is replaced by public transport and cycle traffic. Through the afforestation of Wiental, the area could become a park or recreational route, and the quality of life in the area would improve.An important aspect of the project was dealing with the Danube. We proposed to manage the flood peaks by introducing a dam, and after the point of regulation, we arranged the River into two levels: an ambient upper flow and infrastructural lower flow in the existing channel. Also, by rearranging "Naschmarkt" with the Danube uncovered, we predicted an extension of tourism from the city centre to Schönbrunn by bicycle or on foot, which could be followed by an expansion of the public programme. We wanted to show that the Danube, with an appropriate environment, could become a significant element of the city structure.

  4. Will the warmer temperature bring the more intensity precipitation?

    Science.gov (United States)

    Yutong, Z., II; Wang, T.

    2017-12-01

    Will the warmer temperature bring the more intensity precipitation?Over the past several decades, changes in climate are amplified over the Tibetan Plateau(TP), with warming trend almost being twice as large as the global average. In sharp contrast, there is a large spatial discrepancy of the variations in precipitation extremes, with increasing trends found in the southern and decreasing trends in central TP. These features motivate are urgent need for an observation-based understanding of how precipitation extremes respond to climate change. Here we examine the relation between precipitation intensity with atmospheric temperature, dew point temperature (Td) and convective available potential energy (CAPE) in Tibet Plateau. Owing to the influences of the westerlies and Indian monsoon on Tibetan climate, the stations can be divided into three sub-regions in TP: the westerlies region (north of 35°N, N = 28), the monsoon region (south of 30°N in TP, N = 31), and the transition region (located between 30°N and 35°N, N = 48). We found that the intensity precipitation does not follow the C-C relation and there is a mix of positive and negative slope. To better understand why different scaling occurs with temperature in district region, using the dew point temperature replace the temperature, although there is significant variability in relative humidity values, at most stations, there appears to be a general increase in relative humidity associated. It is likely that the observed rise in relative humidity can assist in explaining the negative scaling of extreme precipitation at westerlies domain and monsoon domain, with the primary reason why precipitation extremes expected to increase follows from the fact that a warmer atmosphere can "hold" more moisture. This suggests that not only on how much the moisture the atmosphere can hold, but on how much moisture exits in atmosphere. To understand the role of dynamic on extreme precipitation, we repeat the precipitation

  5. Trastuzumab emtansine: first global approval.

    Science.gov (United States)

    Ballantyne, Anita; Dhillon, Sohita

    2013-05-01

    Genentech and ImmunoGen are collaborating on the development of trastuzumab emtansine, a HER2 antibody-drug conjugate that comprises Genentech's trastuzumab antibody linked to ImmunoGen's anti-mitotic agent, mertansine (a maytansine derivative; also known as DM1). The conjugate combines two strategies: the anti-HER2 activity of trastuzumab, and the targeted intracellular delivery of mertansine, a tubulin polymerisation inhibitor which interferes with mitosis and promotes apoptosis. The linker in trastuzumab emtansine is a non-reducible thioether linker, N-succinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate (SMCC, designated MCC after conjugation). Trastuzumab emtansine (Kadcyla™) has been launched in the USA as second-line monotherapy for HER2-positive metastatic breast cancer, and has been filed for approval in the EU and Japan in this indication. Trastuzumab emtansine is in phase III development as first-line combination therapy or monotherapy for metastatic HER2-positive breast cancer, and as third-line monotherapy for metastatic HER2-positive breast cancer. Phase II development is underway for early-stage breast cancer and phase II/III development is underway in patients with HER2-positive gastric cancer. This article summarizes the milestones in the development of trastuzumab emtansine leading to this first approval for the treatment of patients with HER2-positive, metastatic breast cancer who previously received trastuzumab and a taxane, separately or in combination.

  6. Growing Your Own: developing leaders through succession planning

    Directory of Open Access Journals (Sweden)

    Anne Murray

    2007-12-01

    Full Text Available Few professions have spent as much time contemplating their present and future as have academic librarians. Conspicuous by its absence until recently has been any systematic discussion of leadership, and more specifically the process of succession planning. In this paper I will argue that neglect of succession planning reflects a series of widespread assumptions which, even if once valid, can no longer inform strategic planning for academic libraries. Although it is clear that there are risks attached to succession planning, the experience of Cambridge University Library highlights both the need for such an exercise and the advantages that it can bring to the profession of academic librarianship as a whole.

  7. Uniquely positioned for future success

    International Nuclear Information System (INIS)

    Thorn, D.

    2001-01-01

    The author began this presentation by giving a corporate profile of PanCanadian, discussing its evolution over time to it being spun-off of PanCanadian Petroleum Limited from Canadian Pacific to form PanCanadian Energy Corporation in 2001. The worldwide activities were mentioned. PanCanadian Petroleum Limited is one of the country's largest producers, experiencing emerging international exploration success, and marketing energy throughout North America. It is also a company that is financially strong. PanCanadian is involved in natural gas, crude, natural gas liquids, and power. An outline of PanCanadian Energy Services was provided, along with its strategic positioning. The next section of the presentation focused on Nova Scotia natural gas, beginning with a map displaying the Eastern Canada development. The focus shifted to the Deep Panuke field, where exploration began in early 1999. PanCanadian holds 20 per cent of the Scotian Shelf. The industry activity offshore Nova Scotia began with the first well in 1967, and to date 178 wells have been drilled, of which 106 were exploration wells. There have been 21 significant discoveries. Production in the Deep Panuke is expected to begin during the first quarter of 2005. The various approval agencies were listed. With large interests held in the offshore Nova Scotia and extensive exploration plans, PanCanadian opportunity in Eastern Canada, New England and the Mid-Atlantic markets has greatly increased. refs., tabs., figs

  8. Twenty-first century learning for teachers: helping educators bring new skills into the classroom.

    Science.gov (United States)

    Wilson, John I

    2006-01-01

    The motivation behind every educator's dedication and hard work in the classroom is the knowledge that his or her teaching will result in students' success in life. Educators are committed to implementing twenty-first century skills; they have no question that students need such skills to be equipped for life beyond school. Members of the National Education Association are enthusiastic about the Partnership for 21st Century Skills framework, yet express frustration that many schools do not have adequate resources to make the necessary changes. Teaching these skills poses significant new responsibilities for schools and educators. To make it possible for teachers to build twenty-first century skills into the curriculum, physical and policy infrastructures must exist, professional development and curriculum materials must be offered, and meaningful assessments must be available. With an established understanding of what skills need to be infused into the classroom-problem solving, analysis, and com- munications-and educators' commitment to the new skill set, this chapter explores how to make such a dramatic reform happen. The author discusses existing strategies that will guide educators in infusing twenty-first century skills into traditional content areas such as math, English, geography, and science. Ultimately, public policy regarding educational standards, professional development, assessments, and physical school structures must exist to enable educators to employ twenty-first century skills, leading to student success in contemporary life. Any concern about the cost of bringing this nation's educational system up to par internationally should be offset by the price that not making twenty-first century skills a priority in the classroom will have on future economic well-being.

  9. Key Success Factors in Business Intelligence

    Directory of Open Access Journals (Sweden)

    Szymon Adamala

    2011-12-01

    Full Text Available Business Intelligence can bring critical capabilities to an organization, but the implementation of such capabilities is often plagued with problems. Why is it that certain projects fail, while others succeed? The aim of this article is to identify the factors that are present in successful Business Intelligence projects and to organize them into a framework of critical success factors. A survey was conducted during the spring of 2011 to collect primary data on Business Intelligence projects. Findings confirm that Business Intelligence projects are wrestling with both technological and non-technological problems, but the non-technological problems are found to be harder to solve as well as more time consuming than their counterparts. The study also shows that critical success factors for Business Intelligence projects are different from success factors for Information Systems projects in general. Business Intelligences projects have critical success factors that are unique to the subject matter. Major differences can be found primarily among non-technological factors, such as the presence of a specific business need and a clear vision to guide the project. Success depends on types of project funding, the business value provided by each iteration in the project and the alignment of the project to a strategic vision for Business Intelligence at large. Furthermore, the study provides a framework for critical success factors that, explains sixty-one percent of variability of success for projects. Areas which should be given special attention include making sure that the Business Intelligence solution is built with the end users in mind, that the Business Intelligence solution is closely tied to the company’s strategic vision and that the project is properly scoped and prioritized to concentrate on the best opportunities first.

  10. A Model of Successful School Leadership from the International Successful School Principalship Project

    Directory of Open Access Journals (Sweden)

    David Gurr

    2015-03-01

    Full Text Available The International Successful School Principalship Project (ISSPP has been actively conducting research about the work of successful principals since 2001. Findings from four project books and eight models derived from this project are synthesised into a model of successful school leadership. Building on Gurr, Drysdale and Mulford’s earlier model, the work of school leaders is described as engaging within the school context to influence student and school outcomes through interventions in teaching and learning, school capacity building, and the wider context. The qualities a leader brings to their role, a portfolio approach to using leadership ideas, constructing networks, collaborations and partnerships, and utilising accountability and evaluation for evidence-informed improvement, are important additional elements. The model is applicable to all in leadership roles in schools.

  11. From the Moon: Bringing Space Science to Diverse Audiences

    Science.gov (United States)

    Runyon, C. J.; Hall, C.; Joyner, E.; Meyer, H. M.; M3 Science; E/PO Team

    2011-12-01

    NASA's Apollo missions held a place in the mindset of many Americans - we dared to go someplace where humans had never set foot, a place unknown and beyond our imaginations. These early NASA missions and discoveries resulted in an enhanced public understanding of the Moon. Now, with the human element so far removed from space exploration, students must rely on textbooks, TV's, and computers to build their understanding of our Moon. However, NASA educational materials about the Moon are stale and out-of-date. In addition, they do not effectively address 21st Century Skills, an essential for today's classrooms. Here, we present a three-part model for developing opportunities in lunar science education professional development that is replicable and sustainable and integrates NASA mission-derived data (e.g., Moon Mineralogy Mapper (M3)/Chandrayaan-1). I) With the return of high resolution/high spatial data from M3/Chandrayaan-1, we can now better explore and understand the compositional variations on the lunar surface. Data and analysis techniques from the imaging spectrometer are incorporated into the M3 Educator's Guide: Seeing the Moon in a New Light. The guide includes an array of activities and lessons to help educators and students understand how NASA is currently exploring the Moon. The guide integrates NASA maps and data into the interactive lessons, bringing the excitement of scientific exploration and discovery into the classroom. II) Utilizing the M3 Educator's Guide as well as educational activities from more current NASA lunar missions, we offer two sustained professional development opportunities for educators to explore the Moon through interactive and creative strategies. 1) Geology of the Moon, an online course offered through Montana State University's National Teacher Enhancement Network, is a 3-credit graduate course. 2) Fly Me to the Moon, offered through the College of Charleston's Office of Professional Development in Education, is a two

  12. 7 CFR 1735.90 - Preliminary approvals.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE GENERAL POLICIES, TYPES OF LOANS, LOAN REQUIREMENTS-TELECOMMUNICATIONS PROGRAM Requirements for... franchises, licenses, and permits; (4) All required regulatory body approvals; (5) All required corporate...

  13. Marketing Approval of Ethical Kampo Medicines.

    Science.gov (United States)

    Hakamatsuka, Takashi

    2017-01-01

    Kampo medicine is an original traditional medicine in Japan. Currently, 148 ethical Kampo formulations (Kampo prescription drugs) are registered in the National Health Insurance Price List. Kampo medicines can be prescribed under the national insurance system, which shows that they are part of conventional medicine in Japan. Japan has a unified drug approval system that does not distinguish between Western and Kampo medicines, and both are subject to the same regulations. The application for the market approval of ethical Kampo medicines is based on the general notification for drugs, i.e., "Handling of Ethical Combination Drugs" in "Precautions Necessary When Applying for Drug Marketing Approval" (Yakushokushinsa Notification No. 1121-12 of November 21, 2014). Furthermore, applications for the market approval of ethical Kampo medicines should follow the Kampo-specific notification of "Handling of Ethical Kampo Medicines" (Yakushin Notification No. 804 of June 25, 1980). Data from comparative studies with standard decoctions must be submitted with approval applications according to Yakushin 2 Notification No. 120 of May 31, 1985. The safety, efficacy, and quality of Kampo medicines are comprehensively assured by the Japanese Pharmacopoeia, Good Manufacturing Practice, Good Agricultural and Collection Practices, marketing approval certificate, approval standard, and pharmacovigilance. I believe that the basic framework for the market approval of ethical Kampo medicines has been established as described above. The key factors for the practical application of superior manufacturing technology and research achievements and the promotion of drug development are the specific guidelines for the approval of drugs of herbal origin.

  14. OMB Recommended vs Approved Operating Budget

    Data.gov (United States)

    Montgomery County of Maryland — This dataset includes the Fiscal Year 2015 County Executive Recommended and County Council Approved operating budgets for Montgomery County, for comparison purposes....

  15. Business Intelligence Success Factors

    DEFF Research Database (Denmark)

    Gaardboe, Rikke; Jonasen, Tanja Svarre

    2018-01-01

    Business intelligence (BI) is a strategically important practice in many organizations. Several studies have investigated the factors that contribute to BI success; however, an overview of the critical success factors (CSFs) involved is lacking in the extant literature. We have integrated...... 34 CSFs related to BI success. The distinct CSFs identified in the extant literature relate to project management skills (13 papers), management support (20 papers), and user involvement (11 papers). In the articles with operationalized BI success, we found several distinct factors: system quality...

  16. Spin-offs from Research Exhibition Science Bringing Nations Together

    CERN Multimedia

    1997-01-01

    It is well known that the results of fundamental research can have unexpected and suc-cessful applications in different fields of human activity. A good example is that of nuclear track membranes. These membranes are produced by exposing polymer films to ion beams at isochronous cyclotrons in JINR. They are used in all fields that require reliable and ecologically safe filters; e.g. in medicine and in the food and elec-tronics industries. It is not surprising that Finnish businessmen readily accepted the proposal of the specialists from JINR's Laboratory of Nuclear Reactions to establish a joint venture for production of household water filters, and that these simple but effective devices are now used in many countries.

  17. MNR Approvals for waterpower projects

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    On May 5, 2011, the Ontario Waterpower Association hosted the emergent hydro workshop in Peterborough. In the course of the workshop, the Ministry of Natural Resources (MNR) presented the different requirements for approval of waterpower projects. Various legislation administered by MNR applies to waterpower projects: the Public Lands Act, the Lakes and Rivers Improvement Act, the Endangered Species Act, 2007, and other legislation. The Public Lands Act provides policy and procedure for water power site release; the Lakes and Rivers Improvement Act was designed to manage, protect and preserve waters, land, fish, wildlife and other natural resources; the Endangered Species Act, 2007, is intended to protect species from extinction by protecting their habitats and promoting their recovery. MNR also administer other legislation, including the Aggregate Resources Act and the Forest Fires Prevention Act. This presentation provided an overview of the various pieces of legislation regulating waterpower projects which are administered by MNR.

  18. Polypharmacology of Approved Anticancer Drugs.

    Science.gov (United States)

    Amelio, Ivano; Lisitsa, Andrey; Knight, Richard A; Melino, Gerry; Antonov, Alexey V

    2017-01-01

    The major drug discovery efforts in oncology have been concentrated on the development of selective molecules that are supposed to act specifically on one anticancer mechanism by modulating a single or several closely related drug targets. However, a bird's eye view on data from multiple available bioassays implies that most approved anticancer agents do, in fact, target many more proteins with different functions. Here we will review and systematize currently available information on the targets of several anticancer drugs along with revision of their potential mechanisms of action. Polypharmacology of the current antineoplastic agents suggests that drug clinical efficacy in oncology can be achieved only via modulation of multiple cellular mechanisms. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  19. Authority approvals and environmental investigations

    International Nuclear Information System (INIS)

    Olsen, F.A.; Svenson, J.

    1999-01-01

    The possible sites have been reviewed environmentally and approved in principle by the Danish authorities through 'The Offshore Wind Turbine Committee'. Therefore, environmental studies were not expected to form par of this study. However, the contacts to the authorities revealed a need for further investigations. A required Environmental Impact Study shall be performed in accordance with EC directive of June 27 1985 and March 3 1997, and more specific requirements from the Danish authorities. The possible visual impacts of the proposed large scale offshore project at Roedsand proved to be a major issue for the local acceptance of the projects. Therefore, computer aided visualisations of selected views of all 3 projects were performed and presented to the public. The visualisations were performed with dedicated computer programmes and are presented on colour photos seen from land, sea and air. As a conclusion, the possible visual impact of the proposed projects are not found to be prohibitive for a realisation of the proposed projects. (LN)

  20. The transport system approval concept

    International Nuclear Information System (INIS)

    Pettersson, B.G.

    1991-01-01

    The needs for, and merits of, a new concept for the safety assessment and approval of shipments of radioactive materials is introduced and discussed. The purpose of the new concept is to enable and encourage integration of analysis and review of transport safety with similar safety analysis and review of the handling operations involving the radioactive material at the despatching and receiving ends of a shipment. Safety contributing elements or functions of the means of transport (the Transport System) can thus readily be taken into account in the assessment. The objective is to avoid constraints -experienced or potential - introduced by the package functional provisions contained in the transport regulations, whilst maintaining safety during transport, as well as during facility handling operations, at least at the level at the level currently established. (author)

  1. Examining Management Success Potential.

    Science.gov (United States)

    Quatrano, Louis A.

    The derivation of a model of management success potential in hospitals or health services administration is described. A questionnaire developed to assess management success potential in health administration students was voluntarily completed by approximately 700 incoming graduate students in 35 university health services administration programs…

  2. Ingredients for successful partnerships

    NARCIS (Netherlands)

    S.M. Pfisterer (Stella)

    2011-01-01

    textabstractFor the development of new cross-sector partnerships it is required to know what the essence of successful partnership projects is. Which factors influence success or failure of partnerships is highly related to the specific context where partnerships operate. The literature on critical

  3. Human Resource Outsourcing Success

    OpenAIRE

    Hasliza Abdul-Halim; Elaine Ee; T. Ramayah; Noor Hazlina Ahmad

    2014-01-01

    The existing literature on partnership seems to take the relationship between partnership quality and outsourcing success for granted. Therefore, this article aims at examining the role of service quality in strengthening the relationship between partnership quality and human resource (HR) outsourcing success. The samples were obtained from 96 manufacturing organizations in Penang, Malaysia. The results showed that par...

  4. Planning for College Success

    Science.gov (United States)

    PEPNet, 2009

    2009-01-01

    "Planning for College Success" (PCS) is a curriculum model designed by Sharon Downs, M.S., for a course intended to assist deaf and hard of hearing students during their initial introduction to college life. This program allows students to work one-on-one with a counselor to plan for their college success. The program includes short-term goals and…

  5. Bringing New Families to the Museum One Baby at a Time

    Science.gov (United States)

    Herman, Alicia

    2012-01-01

    "Bring Your Baby to the Danforth Museum of Art" is a program for mothers. Unlike other museum programs that focus on the needs of children, Bring Your Baby caters to the intellectual interests of the adult parent. Parents learn about artworks, play with babies in a beautiful environment, and socialize with other families. The program is…

  6. Features of course definition system control for a mode of preliminary bringing to horizon

    Directory of Open Access Journals (Sweden)

    О.А. Сущенко

    2004-03-01

    Full Text Available  The features of course definition system consisting of   platform in gimbal suspension, tuned rotor gyroscopes and pendulous accelerometers for a mode of preliminary bringing to horizon are reviewed. The mathematical description of the mode of preliminary bringing to horizon is derived and the appropriate control moments are determined.

  7. 29 CFR 779.110 - Employees in retailing whose activities may bring them under the Act.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Employees in retailing whose activities may bring them under the Act. 779.110 Section 779.110 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR... Production of Goods for Commerce § 779.110 Employees in retailing whose activities may bring them under the...

  8. Fleet DNA Brings Fleet Data to Life, Informs R&D | NREL

    Science.gov (United States)

    Fleet DNA Brings Fleet Data to Life, Informs R&D Science and Technology Highlights Highlights in Research & Development Fleet DNA Brings Fleet Data to Life, Informs R&D Key Research Results Achievement Built on over 11.5 million miles of vehicle operations data, Fleet DNA helps users

  9. Fleet DNA Brings Fleet Data to Life, Informs R&D | News | NREL

    Science.gov (United States)

    Fleet DNA Brings Fleet Data to Life, Informs R&D Fleet DNA Brings Fleet Data to Life, Informs R De La Rosa, NREL 34672 The Fleet DNA clearinghouse of commercial vehicle operations data features Odyne-have tapped into Fleet DNA." The data-driven insight and decision-making capabilities

  10. Mergers: Success versus failure

    International Nuclear Information System (INIS)

    Carley, G. R.

    1997-01-01

    Successful mergers in the context of long-term value creation, as measured by return realized on investor-provided capital, were discussed. In essence, a successful merger is characterized by being motivated by a sound business reason and strategy for the merger, a reasonable price and sound execution. The acquiror's pre-merger success in managing a company is a good indicator of future success. Poorly managed companies that acquire other companies generally continue to be poorly managed with no significant increase in shareholder value. Prior to the acquisition, identification of the potential target, assessment of the people involved on both sides of the transaction, thorough knowledge of the target's potential for value creation, financial implications (debt, equity, terms and demand, tax implications, the potential effect of the proposed acquisition on the acquiror's business plan) and finally the execution of the process itself, are the important determinants of successful mergers

  11. 19 CFR 115.41 - Certificate of approval for containers approved after manufacture.

    Science.gov (United States)

    2010-04-01

    ... after manufacture. 115.41 Section 115.41 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT... PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS Procedures for Approval of Containers After Manufacture § 115.41 Certificate of approval for containers approved after manufacture. The Certifying Authority shall...

  12. Food and Drug Administration Drug Approval Process: A History and Overview.

    Science.gov (United States)

    Williams, Christopher Ty

    2016-03-01

    In this article, the processing of investigational and new drug applications is described and the standard and expedited review processes are examined. The efforts of the US Food and Drug Administration to ensure greater agency transparency and fiscal responsibility and intensify oversight during the drug development and approval process are reviewed. Often attributed to a decrease in the number of uninsured adults, both the increase in prescription drug sales and the high costs associated with bringing a new drug to market highlight the necessity for a streamlined and cost-effective process to deliver these drugs safely and effectively. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Bringing High Rate, Low Latency Data From Unimak Island, Alaska

    Science.gov (United States)

    Feaux, K.; Jackson, M.; Mencin, D.; Gallaher, W.; Smith, S.; Bohnenstiehl, K.; Borsa, A.; Enders, M.; Coyle, B.; Paskievitch, J.; Read, C.

    2009-05-01

    The Plate Boundary Observatory (PBO), part of the NSF-funded EarthScope project, completed the installation of a fourteen GPS stations, eight tiltmeters, one webcam, and one digital broadband seismometer on Unimak Island, Alaska in August, 2008. PBO collaborated with the USGS, who provided engineering support for this project. Combined with the USGS operated seismic network, the Unimak Island network is a state of the art scientific network. The primary data communications goal of the project was to design and implement a robust data communications network capable of downloading 15-sec daily GPS files and to test the streaming of 1- Hz GPS data at a select set of GPS stations on Unimak Island. As part of the permitting agreement with the landowner, PBO co-located the GPS stations with existing USGS seismic stations. The high-speed radio link deployed allowed the USGS to test the feasibility of broadband seismometer installations on Unimak Island. This collaboration with the USGS was another successful joint operation between PBO and the USGS. The technical and logistical challenges involved in the project as well as some preliminary results of the data communications system will be presented. These challenges include complicated logistics, bad weather, complex network geometries with multiple radio repeaters, long distance RF transmission over water, hardware bandwidth limitations, power limitations, space limitations, as well as working in bear country on an incredibly remote and active volcano.

  14. Campus Grids: Bringing Additional Computational Resources to HEP Researchers

    International Nuclear Information System (INIS)

    Weitzel, Derek; Fraser, Dan; Bockelman, Brian; Swanson, David

    2012-01-01

    It is common at research institutions to maintain multiple clusters that represent different owners or generations of hardware, or that fulfill different needs and policies. Many of these clusters are consistently under utilized while researchers on campus could greatly benefit from these unused capabilities. By leveraging principles from the Open Science Grid it is now possible to utilize these resources by forming a lightweight campus grid. The campus grids framework enables jobs that are submitted to one cluster to overflow, when necessary, to other clusters within the campus using whatever authentication mechanisms are available on campus. This framework is currently being used on several campuses to run HEP and other science jobs. Further, the framework has in some cases been expanded beyond the campus boundary by bridging campus grids into a regional grid, and can even be used to integrate resources from a national cyberinfrastructure such as the Open Science Grid. This paper will highlight 18 months of operational experiences creating campus grids in the US, and the different campus configurations that have successfully utilized the campus grid infrastructure.

  15. LHC Report: Boost in bunches brings record luminosity

    CERN Multimedia

    2011-01-01

    Having hit a luminosity of around 8.4x1032 cm-2 s-1 with 768 bunches per beam, the LHC went into a 5-day machine development (MD) program on Wednesday 4 May. Operators are now working on increasing the number of particle bunches in the machine towards a 2011 maximum of around 1380 bunches. The team is already hitting major milestones, recording another record-breaking peak luminosity on Monday 23 May.   Former LHC Project Leader Lyn Evans (to the right) and Laurette Ponce, the engineer-in-charge when the recent luminosity record was achieved. The MD periods improve our understanding of the machine, with the aim of increasing its short- and long-term performance. This one also included tests of the machine’s configurations for special physics runs and a future high luminosity LHC. It was an intense program and overall it went very well, with most measurements carried out successfully. Highlights included: commissioning a dedicated machine setup for TOTEM and ALFA; succe...

  16. The next frontier: Bringing collaborative care to scale.

    Science.gov (United States)

    Levkovich, Natalie

    2015-12-01

    In my position as CEO of the Health Federation of Philadelphia (HFP), I am acutely aware of the effort required to implement practice transformation, including fully integrated behavioral health (IBH) and primary care. We integrate knowledge of our marketplace, best practices from the field, and the wisdom of our providers to achieve our practice goals. We have found this to be a key to the success of our advocacy, efficient replication, and rapid regional spread of IBH. Even when payment models, the other driving barrier to IBH, catch up and reflect a better fit with the demands of efficiently integrated, whole-person, teambased care, the challenges resulting from lack of implementation support will still exist. That's where the Collaborative Family Healthcare Association (CFHA) comes in. CFHA can be that centralized and reliable structure to help guide the planning and application of the essential core elements of integrated care: aligned systems, metrics and operations; patient and family centered approaches; workforce competencies; and strategies for stakeholder engagement. In spite of its influence, integrity, and accomplishments, CFHA is still a "too-well-kept secret." By embracing a focused approach, strategic partnerships, clear communication of our unique strengths and capabilities, and the collective might that exists within our own CFHA family, CFHA can grow and thrive and continue to lead the field of collaborative family health care. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

  17. E-Approval Plans in Research Libraries

    Science.gov (United States)

    Pickett, Carmelita; Tabacaru, Simona; Harrell, Jeanne

    2014-01-01

    Research libraries have long invested in approval plan services, which offer an economical way to acquire scholarly and scientific publications. Traditional approval plans have evolved and now enable libraries to expand their e-book offerings to better serve researchers. Publishers offer a myriad of e-book purchasing options. These range from…

  18. 48 CFR 2922.103-4 - Approvals.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Approvals. 2922.103-4 Section 2922.103-4 Federal Acquisition Regulations System DEPARTMENT OF LABOR SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Basic Labor Policies 2922.103-4 Approvals. The “agency...

  19. 38 CFR 21.7220 - Course approval.

    Science.gov (United States)

    2010-07-01

    ...) VOCATIONAL REHABILITATION AND EDUCATION All Volunteer Force Educational Assistance Program (Montgomery GI...; Pub. L. 98-525) (b) Course approval criteria. In administering benefits payable under 38 U.S.C...) Section 21.4265—Practical training approved as institutional training or on-job training; (10) Section 21...

  20. Ordinal Position, Approval Motivation, and Interpersonal Attraction

    Science.gov (United States)

    Nowicki, Stephen, Jr.

    1971-01-01

    Results of the study suggest that birth-order effects might be included within the wider framework of approval-dependency theory. Females tend to account for a significant share of birth-order effects. More particularly, firstborn females accounted for much of the differences in expressed attraction as well as need for social approval. (Author)

  1. Success and anomy of the corporal

    Directory of Open Access Journals (Sweden)

    Larisa Viktorovna Efimova

    2015-11-01

    Full Text Available The success and its anomichny manifestation in modern society becomes object of research of article. The success represents material prosperity and high position of the person in society, but ways of its achievement connected with knowledge, professionalism, working capacity, ability to make decisions and creativity are held back, negatively affecting interpretative practicians of a phenomenon mass consciousness. In the most Russian society the anomichnost of a state in which the dialectic interrelation of its social and individual modes is highlighted is found today. The anomy acts as an indicator of a mismatch of the purposes and standards of life, causing violations traditional, standard правовового, axiological. And individual acts as the most indicative illustration of an anomichnost of the social corporal as a component of modern success. The corporality is located in a discourse sexual today that involves artificial transformations of a body and as a result brings to a body/corporality razjyatiya from the owner. The success anomichnost situation by means of corporal transformations demands revival reflexive, traditional, moral and legal, restrictions manipulative the practician of mass media.

  2. Issues for bringing digital libraries into public use

    Science.gov (United States)

    Flater, David W.; Yesha, Yelena

    1993-01-01

    In much the same way that the field of artificial intelligence produced a cult which fervently believed that computers would soon think like human beings, the existence of electronic books has resurrected the paperless society as a utopian vision to some, an apocalyptic horror to others. In this essay we have attempted to provide realistic notions of what digital libraries are likely to become if they are a popular success. E-books are capable of subsuming most of the media we use today and have the potential for added functionality by being interactive. The environmental impact of having millions more computers will be offset to some degree, perhaps even exceeded, by the fact that televisions, stereos, VCR's, CD players, newspapers, magazines, and books will become part of the computer system or be made redundant. On the whole, large-scale use of digital libraries is likely to be a winning proposition. Whether or not this comes to pass depends on the directions taken by today's researchers and software developers. By involving the public, the effort being put into digital libraries can be leveraged into something which is big enough to make a real change for the better. If digital libraries remain the exclusive property of government, universities, and large research firms, then large parts of the world will remain without digital libraries for years to come, just as they have remained without digital phone service for far too long. If software companies try to scuttle the project by patenting crucial algorithms and using proprietary data formats, all of us will suffer. Let us reverse the errors of the past and create a truly open digital library system.

  3. Prison hospice: an unlikely success.

    Science.gov (United States)

    Craig, E L; Craig, R E

    1999-01-01

    Efforts to introduce hospice and palliative care into American prisons have become fairly widespread, in response to the sharp increase in inmate deaths. The primary impetus originally came from the alarming number of AIDS deaths among prisoners. The new combination therapies have proved very successful in treating AIDS, but are very costly, and many problems must be overcome to ensure their effectiveness in correctional settings. Although the AIDS epidemic seems to be in decline, prisons are experiencing a rise in the number of deaths due to "natural causes." In this article we present a review of the prison hospice scene--the response to this crisis in correctional health care. First, we discuss the challenges facing the introduction of hospice into the correctional setting. Then, we present a brief overview of recent developments and a discussion of some ways hospice components have been adapted for life behind bars. Finally, we indicate some of the prospects for the future. Hospice professionals, armed with thorough professional training and years of experience, often fear that correctional health care providers will only parody superficial aspects of the hospice approach. Continual nudging and nurturing by local and state hospice professionals is required in order to bring about this change in the first place and to sustain it through time. Prison hospice workers need not only initial training, but also ongoing education and personal contact with experienced hospice professionals. While the interest of the big national organizations is necessary, the real action happens when local hospices work with nearby prisons to attend to the needs of dying inmates.

  4. Successful removable partial dentures.

    Science.gov (United States)

    Lynch, Christopher D

    2012-03-01

    Removable partial dentures (RPDs) remain a mainstay of prosthodontic care for partially dentate patients. Appropriately designed, they can restore masticatory efficiency, improve aesthetics and speech, and help secure overall oral health. However, challenges remain in providing such treatments, including maintaining adequate plaque control, achieving adequate retention, and facilitating patient tolerance. The aim of this paper is to review the successful provision of RPDs. Removable partial dentures are a successful form of treatment for replacing missing teeth, and can be successfully provided with appropriate design and fabrication concepts in mind.

  5. 30 CFR 14.10 - Post-approval product audit.

    Science.gov (United States)

    2010-07-01

    ..., AND APPROVAL OF MINING PRODUCTS REQUIREMENTS FOR THE APPROVAL OF FLAME-RESISTANT CONVEYOR BELTS General Provisions § 14.10 Post-approval product audit. (a) Approved conveyor belts will be subject to... based. MSHA will select an approved conveyor belt to be audited; the selected belt will be...

  6. Analysis of the Education Program Approval Process: A Program Evaluation.

    Science.gov (United States)

    Fountaine, Charles A.; And Others

    A study of the education program approval process involving the Veterans Administration (VA) and the State Approving Agencies (SAAs) had the following objectives: to describe the present education program approval process; to determine time and costs associated with the education program approval process; to describe the approval process at…

  7. ACTS – SUCCESS STORY

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. ACTS – SUCCESS STORY. Totally 103 experiments were conducted and the programme succeeded in the areas. Medicine; Education; Defence; Emergency Response; Maritime and Aeronautical Mobile Communications; Science and Astronomy.

  8. Goodbye Career, Hello Success.

    Science.gov (United States)

    Komisar, Randy

    2000-01-01

    Success in today's economy means throwing out the old career rules. The "noncareer" career is driven by passion for the work and has the fluidity and flexibility needed in the contemporary workplace. (JOW)

  9. Human Resource Outsourcing Success

    Directory of Open Access Journals (Sweden)

    Hasliza Abdul-Halim

    2014-07-01

    Full Text Available The existing literature on partnership seems to take the relationship between partnership quality and outsourcing success for granted. Therefore, this article aims at examining the role of service quality in strengthening the relationship between partnership quality and human resource (HR outsourcing success. The samples were obtained from 96 manufacturing organizations in Penang, Malaysia. The results showed that partnership quality variables such as trust, business understanding, and communication have significant positive impact on HR outsourcing success, whereas in general, service quality was found to partially moderate these relationships. Therefore, comprehending the HR outsourcing relationship in the context of service quality may assist the organizations to accomplish HR outsourcing success by identifying areas of expected benefits and improvements.

  10. Fertility Clinic Success Rates

    Science.gov (United States)

    ... Defects ART and Autism 2013 Assisted Reproductive Technology Fertility Clinic Success Rates Report Recommend on Facebook Tweet ... Additional Information About ART in the United States. Fertility Clinic Tables Introduction to Fertility Clinic Tables [PDF - ...

  11. Successful project management

    CERN Document Server

    Young, Trevor L

    2016-01-01

    Successful Project Management, 5th edition, is an essential guide for anyone who wants to improve the success rate of their projects. It will help managers to maintain a balance between the demands of the customer, the project, the team and the organization. Covering the more technical aspects of a project from start to completion it contains practised and tested techniques, covering project conception and start-up, how to manage stake holders, effective risk management, project planning and launch and execution. Also including a brand new glossary of key terms, it provides help with evaluating your project as well as practical checklists and templates to ensure success for any ambitious project manager. With over one million copies sold, the hugely popular Creating Success series covers a wide variety of topic, with the latest editions including new chapters such as Tough Conversations and Treating People Right. This indispensable business skills collection is suited to a variety of roles, from someone look...

  12. Definition of successful defibrillation

    NARCIS (Netherlands)

    Koster, Rudolph W.; Walker, Robert G.; van Alem, Anouk P.

    2006-01-01

    OBJECTIVES: The definition of defibrillation shock "success" endorsed by the International Liaison Committee on Resuscitation since the publication of Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiac Care has been removal of ventricular fibrillation at 5 secs after shock

  13. Succession planning : phase II.

    Science.gov (United States)

    2008-06-01

    Succession planning is an organizational investment in the future. Institutional : knowledge is a critical ingredient in the culture of an organization, and its intangible : value becomes significant when an organization is faced with the need to pas...

  14. Bringing Terramechanics to bear on Planetary Rover Design

    Science.gov (United States)

    Richter, L.

    2007-08-01

    Thus far, planetary rovers have been successfully operated on the Earth's moon and on Mars. In particular, the two NASA Mars Exploration Rovers (MERs) ,Spirit' and ,Opportunity' are still in sustained daily operations at two sites on Mars more than 3 years after landing there. Currently, several new planetary rover missions are in development targeting Mars (the US Mars Science Lab vehicle for launch in 2009 and ESA's ExoMars rover for launch in 2013), with lunar rover missions under study by China and Japan for launches around 2012. Moreover, the US Constellation program is preparing pre-development of lunar rovers for initially unmanned and, subsequently, human missions to the Moon with a corresponding team dedicated to mobility system development having been set up at the NASA Glenn Research Center. Given this dynamic environment, it was found timely to establish an expert group on off-the-road mobility as relevant for robotic vehicles that would involve individuals representing the various on-going efforts on the different continents. This was realized through the International Society of Terrain-Vehicle Systems (ISTVS), a research organisation devoted to terramechanics and to the ,science' of off-the-road vehicle development which as a result is just now establishing a Technical Group on Terrestrial and Planetary Rovers. Members represent space-related as well as military research institutes and universities from the US, Germany, Italy, and Japan. The group's charter for 2007 is to define its objectives, functions, organizational structure and recommended research objectives to support planetary rover design and development. Expected areas of activity of the ISTVS-sponsored group include: the problem of terrain specification for planetary rovers; identification of limitations in modelling of rover mobility; a survey of existing rover mobility testbeds; the consolidation of mobility predictive models and their state of validation; sensing and real

  15. Research into Success

    Directory of Open Access Journals (Sweden)

    Bogomir Novak

    1997-12-01

    Full Text Available As competition is becoming ever more fierce, research into the prerequisites for success is gaining ground. By most people, success is perceived as an external phenomenon, but it is in fact the consequence of a person's readiness to perform in the world (of business. In the paper, Novak distinguishes between internal, external and group success. The essence of interna!success, which is the condition for the other two types of success, is assuming responsibility for, and exercising self-control over one's psychic phenomena. This in fact means that one needs to "reprogramme" the old patterns of behaviour and substitute them for the new, which leads to personality changes based on the understanding and acceptance of the self and others as they are. In realizing personal abilities, motives and goals, mental guiding laws must also be taken into account. Nowadays, the overall success of an organization is an important indicator of the quality of gro up work. The working patterns of individuals comply with the patterns used by his or her colleagues. When we do something for ourselves, we do it for others. In certain organizations, through accepted ways of communication all people become successful, and no body needs to be paid off. Employees wholly identify themselves with their organization, and vice versa. This three-part paradigm (I-Others-Community is the basis for various models of practical training for success, which are often idealized, but are primarily aimed at abolishing passivity and flaws in the system and its wider environment.

  16. Reflection of successful anticancer drug development processes in the literature.

    Science.gov (United States)

    Heinemann, Fabian; Huber, Torsten; Meisel, Christian; Bundschus, Markus; Leser, Ulf

    2016-11-01

    The development of cancer drugs is time-consuming and expensive. In particular, failures in late-stage clinical trials are a major cost driver for pharmaceutical companies. This puts a high demand on methods that provide insights into the success chances of new potential medicines. In this study, we systematically analyze publication patterns emerging along the drug discovery process of targeted cancer therapies, starting from basic research to drug approval - or failure. We find clear differences in the patterns of approved drugs compared with those that failed in Phase II/III. Feeding these features into a machine learning classifier allows us to predict the approval or failure of a targeted cancer drug significantly better than educated guessing. We believe that these findings could lead to novel measures for supporting decision making in drug development. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. 30 CFR 18.95 - Approval of machines constructed of components approved, accepted or certified under Bureau of...

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Approval of machines constructed of components... APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Field Approval of Electrically Operated Mining Equipment § 18.95 Approval of machines constructed of components approved...

  18. A first attempt to bring computational biology into advanced high school biology classrooms.

    Science.gov (United States)

    Gallagher, Suzanne Renick; Coon, William; Donley, Kristin; Scott, Abby; Goldberg, Debra S

    2011-10-01

    Computer science has become ubiquitous in many areas of biological research, yet most high school and even college students are unaware of this. As a result, many college biology majors graduate without adequate computational skills for contemporary fields of biology. The absence of a computational element in secondary school biology classrooms is of growing concern to the computational biology community and biology teachers who would like to acquaint their students with updated approaches in the discipline. We present a first attempt to correct this absence by introducing a computational biology element to teach genetic evolution into advanced biology classes in two local high schools. Our primary goal was to show students how computation is used in biology and why a basic understanding of computation is necessary for research in many fields of biology. This curriculum is intended to be taught by a computational biologist who has worked with a high school advanced biology teacher to adapt the unit for his/her classroom, but a motivated high school teacher comfortable with mathematics and computing may be able to teach this alone. In this paper, we present our curriculum, which takes into consideration the constraints of the required curriculum, and discuss our experiences teaching it. We describe the successes and challenges we encountered while bringing this unit to high school students, discuss how we addressed these challenges, and make suggestions for future versions of this curriculum.We believe that our curriculum can be a valuable seed for further development of computational activities aimed at high school biology students. Further, our experiences may be of value to others teaching computational biology at this level. Our curriculum can be obtained at http://ecsite.cs.colorado.edu/?page_id=149#biology or by contacting the authors.

  19. Bringing the ecosystem services concept into marine management decisions, supporting ecosystems-based management.

    Science.gov (United States)

    Tweddle, J. F.; Byg, A.; Davies, I.; Gubbins, M.; Irvine, K.; Kafas, A.; Kenter, J.; MacDonald, A.; Murray, R. B. O.; Potts, T.; Slater, A. M.; Wright, K.; Scott, B. E.

    2016-12-01

    The marine environment is under increasing use, putting pressure on marine ecosystems and increasing competition for space. New activities (e.g. renewable energy developments), evolving marine policies (e.g. implementation of marine protected areas), and climate change may drive changes in biodiversity and resulting ecosystem services (ES) that society and business utilise from coastal and marine systems. A process is needed that integrates ecological assessment of changes with stakeholder perceptions and valuation of ES, whilst balancing ease of application with the ability to deal with complex social-economic-ecological issues. The project "Cooperative participatory assessment of the impact of renewable technology on ecosystem services: CORPORATES" involved natural and social scientists, law and policy experts, and marine managers, with the aim of promoting more integrated decision making using ES concepts in marine management. CORPORATES developed a process to bring ES concepts into stakeholders' awareness. The interactive process, involving 2 workshops, employs interludes of knowledge exchange by experts on ecological processes underpinning ES and on law and policy. These enable mapping of benefits linked to activities, participatory system modelling, and deliberation of policy impacts on different sectors. The workshops were attended by industry representatives, regulatory/advisory partners, and other stakeholders (NGOs, SMEs, recreationalists, local government). Mixed sector groups produced new insights into links between activities and ES, and highlighted cross-sector concerns. Here we present the aspects of the process that successfully built shared understanding between industry and stakeholders of inter-linkages and interactions between ES, benefits, activities, and economic and cultural values. These methods provide an ES-based decision-support model for exchanging societal-ecological knowledge and providing stakeholder interaction in marine planning

  20. Evaluation of Music And Astronomy Under The Stars: Bringing Science To New Audiences At Music Events

    Science.gov (United States)

    Lubowich, D.; Torff, B.

    2014-07-01

    Evaluations were conducted of the 2009-2012 NASA-funded Music and Astronomy Under the Stars (MAUS) program at outdoor concerts (see the separate MAUS poster at this meeting). MAUS promoted lifelong learning by providing opportunities for the public to look through telescopes, participate in hands-on activities, and view posters, banners, and videos at events where large numbers of people are gathered. Surveys were given to 1.6% of the concertgoers at MAUS events with the participants expressing their level of agreement on a four-point scale with the following statements: “The astronomy at this event has been an enjoyable experience;” “It has been easy to comprehend the astronomy at this event;” “This event has helped me learn new things about astronomy;” “This event has made me want to learn more about astronomy;” and “This event has increased my interest in science.” On a scale where 1 = strongly disagree, 2 = disagree, 3 = agree, and 4 = strongly agree, MAUS received high ratings (>3.34/4) on all outcomes. MAUS successfully reached people at different concerts who had little interest in science. MAUS appealed to concert attendees of both genders, all ages, multiple levels of education, and all musical tastes. MAUS positively influenced the public's knowledge of and interest in astronomy. The high ratings from virtually all respondents indicate that the gains were not restricted to science enthusiasts. The data strongly supports the conclusion that MAUS—bringing astronomy to people at musical events—is effective!

  1. Catalysts for better health care. Medical tissue banks bring multiple benefits to countries

    International Nuclear Information System (INIS)

    Phillips, G.O.; Morales, J.

    2002-01-01

    For millions of injured and disabled people around the world, the treatment brings a new quality of life. Called tissue grafting or transplantation, it relies on the use of sterilized bone, skin, and other tissues to heal serious injuries, wounds, and sickness. Prime beneficiaries include severe burn victims, and men, women, and children suffering from crippling diseases, birth defects, and blindness. Long applied in plastic and orthopaedic surgery, tissue grafting once relied only on using a patient's own tissues, known as an autograft. But now tissues from human or animal donors (allograft) are used for transplantation. This new form of tissue grafting has made big strides over the past decade. An expanding number of facilities today prepare the valuable tissues to the high-quality standards demanded in medical care. Dozens of such new tissue banks have opened in Asia, Latin America, Europe, and North America. A productive channel of progress has been an IAEA-supported technical cooperation programme. Through it, experts have worked together behind the scenes to help national health authorities establish tissue banks, train associated staff, and develop standards and regulatory guides. The IAEA accordingly has gained more experience and success than any other international organization in supporting the establishment of tissue banks for medical use in developing countries. Increasingly for quality and cost reasons, the technology of irradiation is used to sterilize tissues for medical care. The IAEA, through its technical cooperation channels, assists national atomic energy authorities to safely and productively employ radiation technology. An interregional programme on radiation and tissue banking, initiated over a decade ago, today extends to 30 countries

  2. 27 CFR 5.55 - Certificates of label approval.

    Science.gov (United States)

    2010-04-01

    ..., DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF DISTILLED SPIRITS Requirements for Approval of... certificates of label approval and certificates of exemption from label approval, as well as appeal procedures...

  3. FDA approves efavirenz. Food and Drug Administration.

    Science.gov (United States)

    Highleyman, L

    1998-10-01

    The Food and Drug Administration (FDA) approved DuPont Pharma's new non-nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz (Sustiva, DMP-266). Efavirenz has shown promise in trials with over 2000 participants for up to 24 weeks, and early data suggests it may be as effective as protease inhibitors when used in a combination regimen. It is the first anti-HIV drug approved for once-daily dosing. Efavirenz is well tolerated, and the main side effects reported are dizziness, insomnia, abnormal dreams, and skin rash. Efavirenz has been approved for adults and children, but should not be used by pregnant women. Contact information is provided.

  4. Perspectives used for gaining approval of budgets.

    Science.gov (United States)

    Franks-Joiner, G L

    1990-01-01

    Nurse executives think about problems using a certain perspective which may influence decisions on budgetary matters. The nurse executives' perspective used in decision-making may influence which budget proposals are developed and approved. A study was performed to determine the perspective used by nurse executives in decision-making on supplementary budget item proposals and whether perspective use influenced approval. Findings showed that use of the system view or dual-domain perspective in a proposal may enhance nurse executives' changes of gaining approval.

  5. ENTREPRENEURIAL POTENTIAL AND SUCCESS IN BUSINESS: A STUDY ON ELEMENTS OF CONVERGENCE AND EXPLANATION

    OpenAIRE

    SOUZA,GUSTAVO HENRIQUE SILVA DE; SANTOS,PAULO DA CRUZ FREIRE DOS; LIMA,NILTON CESAR; CRUZ,NICHOLAS JOSEPH TAVARES DA; LEZANA,ÁLVARO GUILLERMO ROJAS

    2016-01-01

    ABSTRACT Purpose: The study aimed to verify whether there is a difference of entrepreneurial potential between successful entrepreneurs and entrepreneurs who have failed; and whether there are variables that may work as a means of prediction to the success or failure of an entrepreneur. Originality/gap/relevance/implications: It brings up an innovative approach to the entrepreneurship researches, which main content is in the empirical operationalization of success and failure on business fo...

  6. Successful ageing for psychiatrists.

    Science.gov (United States)

    Peisah, Carmelle

    2016-04-01

    This paper aims to explore the concept and determinants of successful ageing as they apply to psychiatrists as a group, and as they can be applied specifically to individuals. Successful ageing is a heterogeneous, inclusive concept that is subjectively defined. No longer constrained by the notion of "super-ageing", successful ageing can still be achieved in the face of physical and/or mental illness. Accordingly, it remains within the reach of most of us. It can, and should be, person-specific and individually defined, specific to one's bio-psycho-social and occupational circumstances, and importantly, reserves. Successful professional ageing is predicated upon insight into signature strengths, with selection of realistic goal setting and substitution of new goals, given the dynamic nature of these constructs as we age. Other essential elements are generativity and self-care. Given that insight is key, taking a regular stock or inventory of our reserves across bio-psycho-social domains might be helpful. Importantly, for successful ageing, this needs to be suitably matched to the professional task and load. This lends itself to a renewable personal ageing plan, which should be systemically adopted with routine expectations of self-care and professional responsibility. © The Royal Australian and New Zealand College of Psychiatrists 2015.

  7. Success in transmitting hazard science

    Science.gov (United States)

    Price, J. G.; Garside, T.

    2010-12-01

    Money motivates mitigation. An example of success in communicating scientific information about hazards, coupled with information about available money, is the follow-up action by local governments to actually mitigate. The Nevada Hazard Mitigation Planning Committee helps local governments prepare competitive proposals for federal funds to reduce risks from natural hazards. Composed of volunteers with expertise in emergency management, building standards, and earthquake, flood, and wildfire hazards, the committee advises the Nevada Division of Emergency Management on (1) the content of the State’s hazard mitigation plan and (2) projects that have been proposed by local governments and state agencies for funding from various post- and pre-disaster hazard mitigation programs of the Federal Emergency Management Agency. Local governments must have FEMA-approved hazard mitigation plans in place before they can receive this funding. The committee has been meeting quarterly with elected and appointed county officials, at their offices, to encourage them to update their mitigation plans and apply for this funding. We have settled on a format that includes the county’s giving the committee an overview of its infrastructure, hazards, and preparedness. The committee explains the process for applying for mitigation grants and presents the latest information that we have about earthquake hazards, including locations of nearby active faults, historical seismicity, geodetic strain, loss-estimation modeling, scenarios, and documents about what to do before, during, and after an earthquake. Much of the county-specific information is available on the web. The presentations have been well received, in part because the committee makes the effort to go to their communities, and in part because the committee is helping them attract federal funds for local mitigation of not only earthquake hazards but also floods (including canal breaches) and wildfires, the other major concerns in

  8. Approving of personal dosimeter services

    International Nuclear Information System (INIS)

    Bergman, K.; Malmqvist, L.

    2001-09-01

    The Swedish regulation SSI FS 98:5 requires that radiological workers of category A use dosemeters from an approved personal dosimetry service. The regulation also includes certain specific dosimeter requirements, which are based on those presented in the Technical Recommendations by the European Commission (Report EUR 14852 EN, 1994). All services have been tested for their ability to determine Hp(10) and some of them to determine Hp(0.07) at one radiation quality. The test was performed in the interval 0.2 mSv to 100 mSv at three different dose equivalents unknown to the system owner. The 11 services operating in Sweden at the moment use 5 different types of dosimeters. The five unique systems have been tested regarding the angular and energy dependence of the response of the dosimeters. The dosimeters were irradiated to a personal dose equivalent of about 1 mSv at three photon energies and at four angles (0, 20, 40 and 60 deg. resp. ) both vertically and horizontally rotated. Only 2 of the services determine Hp(0.07) for beta and gamma radiation and were tested for this quantity. The test results for Hp(10) are all except two within the trumpet curve. For the unique systems it is shown that the uncertainty related to angular response at a specified energy is within the required ±40 % except for the lowest X-ray quality at 40 kV. The response is more dependent on photon energy than on the direction of the photon radiation and the choice of radiation quality for the calibration is of great importance for the system performance

  9. Bangladesh becomes "success story".

    Science.gov (United States)

    1999-01-01

    The State Minister for Health and Family of Bangladesh, Dr. Mohammed Amanullah, highlighted some of the successes being achieved by his country in lowering fertility and improving the lives of the people since the 1994 International Conference on Population and Development. Some of these successes include practical measures to eliminate violence against women; introduction of a quota for women in public sector employment; and launching of the Health and Population Sector Program to provide a one-stop, full range of essential reproductive health, family planning and child health services through an integrated delivery mechanism. Moreover, the Minister informed the Forum participants that their success is attributable to many factors which include support from the government, from non-governmental organizations, civil society, mass media, religious and other community leaders, intersectoral collaboration, microcredit and income-generation activities.

  10. Success Factors of the Companies Mergers and Acquisitions

    Directory of Open Access Journals (Sweden)

    Maria Sierpińska

    2007-01-01

    Full Text Available Mergers and acquisitions (MA are one of the most important phenomenons influencing dynamics of the world economy growth. At the same time, big number of acquisitions turns out to be unsuccessful which induces one to examine reasons for failures and factors having influence on success of MA. In the article an attempt to systematize researchers and specialists-practitioners opinions on factors that play a key role in acquisition success was made, as complexity of MA processes causes that only actions resulting from reliable analysis, that are afterwards well planned and carried out may bring results expected by the entities.

  11. 75 FR 29803 - Agency Information Collection Activity Seeking OMB Approval

    Science.gov (United States)

    2010-05-27

    ... Turbine Engine Powered Airplanes. Type of Request: Extension without change of a currently approved....S. EPA pollution requirements in lieu of searching through extensive paper records. ADDRESSES...

  12. Pressure profiles of the BRing based on the simulation used in the CSRm

    Science.gov (United States)

    Wang, J. C.; Li, P.; Yang, J. C.; Yuan, Y. J.; Wu, B.; Chai, Z.; Luo, C.; Dong, Z. Q.; Zheng, W. H.; Zhao, H.; Ruan, S.; Wang, G.; Liu, J.; Chen, X.; Wang, K. D.; Qin, Z. M.; Yin, B.

    2017-07-01

    HIAF-BRing, a new multipurpose accelerator facility of the High Intensity heavy-ion Accelerator Facility project, requires an extremely high vacuum lower than 10-11 mbar to fulfill the requirements of radioactive beam physics and high energy density physics. To achieve the required process pressure, the bench-marked codes of VAKTRAK and Molflow+ are used to simulate the pressure profiles of the BRing system. In order to ensure the accuracy of the implementation of VAKTRAK, the computational results are verified by measured pressure data and compared with a new simulation code BOLIDE on the current synchrotron CSRm. Since the verification of VAKTRAK has been done, the pressure profiles of the BRing are calculated with different parameters such as conductance, out-gassing rates and pumping speeds. According to the computational results, the optimal parameters are selected to achieve the required pressure for the BRing.

  13. Bring Me Men: Intertextual Identity Formation at the US Air Force Academy

    National Research Council Canada - National Science Library

    Schifani, Katherine L

    2008-01-01

    .... It took twenty-one years from when the first class entered in 1955 before the Air Force Academy saw its first women, one walking famously on her first day in front of the "Bring Me Men..." ramp (BMMR...

  14. Pressure profiles of the BRing based on the simulation used in the CSRm

    Energy Technology Data Exchange (ETDEWEB)

    Wang, J.C., E-mail: wangjiachen@impcas.ac.cn [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Li, P., E-mail: lipeng@impcas.ac.cn [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Yang, J.C.; Yuan, Y.J. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Wu, B. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Chai, Z.; Luo, C. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Dong, Z.Q. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Zheng, W.H. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Zhao, H.; Ruan, S.; Wang, G.; Liu, J.; Chen, X.; Wang, K.D.; Qin, Z.M. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Yin, B. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China)

    2017-07-11

    HIAF-BRing, a new multipurpose accelerator facility of the High Intensity heavy-ion Accelerator Facility project, requires an extremely high vacuum lower than 10{sup −11} mbar to fulfill the requirements of radioactive beam physics and high energy density physics. To achieve the required process pressure, the bench-marked codes of VAKTRAK and Molflow+ are used to simulate the pressure profiles of the BRing system. In order to ensure the accuracy of the implementation of VAKTRAK, the computational results are verified by measured pressure data and compared with a new simulation code BOLIDE on the current synchrotron CSRm. Since the verification of VAKTRAK has been done, the pressure profiles of the BRing are calculated with different parameters such as conductance, out-gassing rates and pumping speeds. According to the computational results, the optimal parameters are selected to achieve the required pressure for the BRing.

  15. Improving Security in Bring Your Own Device (BYOD) Environment by Controlling Access

    OpenAIRE

    Muhammad, M.A.; Zadeh, P.B.; Ayesh, Aladdin, 1972-

    2017-01-01

    With the rapid increase in smartphones and tablets, Bring Your Own Devices (BYOD) has simplified computing by introducing the use of personally owned devices. These devices can be utilised in accessing business enterprise contents and networks. The effectiveness of BYOD offers several business benefits like employee job satisfaction, increased job efficiency and flexibility. However, allowing employees to bring their own devices could lead to a plethora of security issues; like data theft, un...

  16. Bring-Your-Own-Device (BYOD): An Evaluation of Associated Risks to Corporate Information Security

    OpenAIRE

    Yeboah-Boateng, Ezer Osei; Boaten, Francis Edmund

    2016-01-01

    This study evaluates the cyber-risks to Business Information Assets posed by the adoption of Bring-Your-Own-Device (BYOD) to the workplace. BYOD is an emerging trend where employees bring and use personal computing devices on the companys network to access applications and sensitive data like emails, calendar and scheduling applications, documents, etc. Employees are captivated by BYOD because they can have access to private items as well as perform certain job functions while being unrestric...

  17. Institutionalization and Organizational Long-term Success

    Directory of Open Access Journals (Sweden)

    Denise L. Fleck

    2007-05-01

    Full Text Available Institutionalization processes have an ambivalent effect on organizational long-term success. Even though they foster organizational stability and permanence, they also bring about rigidity and resistance to change. As a result, successful organizations are likely to lose their competitive advantage over time. The paper addresses this issue through the investigation of the institutionalization processes of two long-lived companies: General Electric, a firm that has been a long-term success and its rival, Westinghouse, which was broken up after eleven decades of existence. The longitudinal, multilevel analysis of firms and industry has identified two different modes of organizational institutionalization. The reactive mode gives rise to rigidity and change resistance, much like institutional theory predicts; the proactive mode, on the other hand, neutralizes those negative effects of institutionalization processes. In the reactive mode, structure predominates. In the proactive mode, agency plays a major role in organizational institutionalization, and in managing the organization’s relations with the environment, clearly contributing to environmental institutionalization.

  18. Drugs Approved for Stomach (Gastric) Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for stomach (gastric) cancer. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  19. Drugs Approved for Gastrointestinal Stromal Tumors

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for gastrointestinal stromal tumors (GIST). The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  20. Drugs Approved for Colon and Rectal Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for use in colon cancer and rectal cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  1. Drugs Approved for Soft Tissue Sarcoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for soft tissue sarcoma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  2. Drugs Approved for Head and Neck Cancer

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for head and neck cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  3. Drugs Approved for Gestational Trophoblastic Disease

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for gestational trophoblastic disease. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  4. FDA Approves First Therapeutic Cancer Vaccine

    Science.gov (United States)

    Sipuleucel-T (Provenge) is a relatively nontoxic treatment option for men with hormone-resistant or castration-resistant prostate cancer. The FDA's approval of the vaccine represented the first proof of principle that immunotherapy can work in cancer.

  5. 19 CFR 115.42 - Approval plates.

    Science.gov (United States)

    2010-04-01

    ... possible methods of accomplishing this are: (1) Placing an “X” in front of the numeric portion of the... element of such number. The specific method of altering the approval number may be established by each...

  6. Page | 133 LEGISLATIVE APPROVAL OF EXECUTIVE ...

    African Journals Online (AJOL)

    Fr. Ikenga

    NAUJILJ 9 (2) 2018. Page | 133 ... Keywords: Executive appointments, Legislative approval, National Assembly, Constitutional duty. 1. ... Representatives is led by a Speaker.6 The election of the leadership of the senate is entirely the affair of.

  7. Therapeutic Fc-fusion proteins and peptides as successful alternatives to antibodies.

    Science.gov (United States)

    Beck, Alain; Reichert, Janice M

    2011-01-01

    Therapeutic antibodies have captured substantial attention due to the relatively high rate at which these products reach marketing approval, and the subsequent commercial success they frequently achieve. In the 2000s, a total of 20 antibodies (18 full-length IgG and 2 Fab) were approved by the Food and Drug Administration (FDA) or European Medicines Agency (EMA). In the 2010s to date, an additional 3 antibodies (denosumab, belimumab, ipilimumab) have been approved and one antibody-drug conjugate (brentuximab vedotin) is undergoing regulatory review and may be approved in the US by August 30, 2011. However, a less heralded group of antibody-based therapeutics comprising proteins or peptides fused with an Fc is following the success of classical antibodies.

  8. SUPERCOLLIDER: String test success

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    On 14 August at the Superconducting Supercollider (SSC) Laboratory in Ellis County, Texas, the Accelerator Systems String Test (ASST) successfully met its objective by operating a half-cell of five collider dipole magnets, one quadrupole magnet, and two spool pieces at the design current of 6500 amperes

  9. Mindfulness and Student Success

    Science.gov (United States)

    Leland, Matt

    2015-01-01

    Mindfulness has long been practiced in Eastern spiritual traditions for personal improvement, and educators and educational institutions have recently begun to explore its usefulness in schools. Mindfulness training can be valuable for helping students be more successful learners and more connected members of an educational community. To determine…

  10. International Student Success

    Science.gov (United States)

    Smith, Clayton

    2016-01-01

    This article, with a focus on North American postsecondary education, identifies international students as a strategic enrollment management institutional priority; presents themes in the international student retention, satisfaction, and success research literature; and describes related best practices. It also presents the findings from an…

  11. America's Success Syndrome

    Science.gov (United States)

    Duplisea, Eric A.

    1974-01-01

    America's earliest schools taught career awareness and job skills, but for 200 years it was a speciality curriculum--cultivating a classical heritage predominated. Recently the hard sell message is that schooling and credentialism ensure entry into the "successful life". Vocational educators must become leaders, explode this myth, and redefine…

  12. Focus on Success

    Science.gov (United States)

    Frey, Susan

    2011-01-01

    Successful middle schools do not happen by accident--they happen through leadership. Principals promote a shared vision that empowers school staffs to set high standards and continuously improve student achievement. And these middle grade educators also try to help their adolescent students see the connection between their work in school and their…

  13. Successful international negotiations

    International Nuclear Information System (INIS)

    Gerry, G.

    1997-01-01

    These remarks on successful international trade negotiations deal with the following topics: culture and differences in psychology; building friendly relationships and letting both sides appear to win; well written proposals; security of negotiating information; the complexity and length of nuclear negotiations

  14. Success in Entrepreneurship

    DEFF Research Database (Denmark)

    Iversen, Jens; Malchow-Møller, Nikolaj; Sørensen, Anders

    2016-01-01

    What makes a successful entrepreneur? Using Danish register data, we find strong support for the hypothesis that theoretical skills from schooling and practical skills acquired through wage-work are complementary inputs in the human capital earnings function of entrepreneurs. In fact, we find tha...

  15. Successfully Adapting to Change.

    Science.gov (United States)

    Baird, James R.

    1989-01-01

    Describes methods used to successfully adapt to reductions in budget allocations in the University of Utah's Instructional Media Services Department. Three main areas of concern are addressed: morale and staff development; adapting to change in the areas of funding, control, media priorities, and technology; and planning for the future. (LRW)

  16. Beyond Success and Failure

    NARCIS (Netherlands)

    Etalle, Sandro; Jaffar, Joxan; van Raamsdonk, Femke

    We study a new programming framework based on logic programming where success and failure are replaced by predicates for adequacy and inadequacy. Adequacy allows to extract a result from a partial computation, and inadequacy allows to flexibly constrain the search space. In this parameterized

  17. Predicting Commissary Store Success

    Science.gov (United States)

    2014-12-01

    stores or if it is possible to predict that success. Multiple studies of private commercial grocery consumer preferences , habits and demographics have...appropriate number of competitors due to the nature of international cultures and consumer preferences . 2. Missing Data Four of the remaining stores

  18. Characteristics of Successful Entrepreneurs.

    Science.gov (United States)

    McClelland, David C.

    1987-01-01

    Comparison of characteristics of 12 average and 12 superior small business people in three developing nations (India, Malawi, and Ecuador) found proactive qualities such as initiative and assertiveness, achievement orientation, and commitment to others characteristic of successful entrepreneurs. Other expected qualities (self-confidence,…

  19. Measuring strategic success.

    Science.gov (United States)

    Gish, Ryan

    2002-08-01

    Strategic triggers and metrics help healthcare providers achieve financial success. Metrics help assess progress toward long-term goals. Triggers signal market changes requiring a change in strategy. All metrics may not move in concert. Organizations need to identify indicators, monitor performance.

  20. Passport to Success

    Science.gov (United States)

    Tomlinson, Nigel

    2002-01-01

    Looks at the "Passport to Success" scheme introduced by the Sheffield Chamber of Commerce in a bid to address the employability skills problem among young people. States that the scheme was launched in September 2001 in partnership with a local comprehensive school with the intention of helping pupils make the transition from school into…

  1. Leading to Success

    Science.gov (United States)

    Koballa, Thomas R., Jr.; Bradbury, Leslie U.

    2009-01-01

    Teacher mentoring has its unique challenges that are often associated with the teachers' content specialties. For this reason, the involvement and support of school leaders is essential to teachers' mentoring success. Regardless of content specialty, all teachers face challenges that should be considered when organizing and implementing mentoring.…

  2. Successful introduction of innovations

    International Nuclear Information System (INIS)

    Schoots, K.; Jeeninga, H.

    2008-01-01

    The introduction of new technology is sometimes troubled by discontinuity in incentive schemes. By making prior assessments of the necessary means, the real time span for the incentive scheme and by maintaining this scheme until the technology is mature enough to enter the market, the success of innovation trajectories can be increased significantly. [mk] [nl

  3. Successful introduction of innovation

    International Nuclear Information System (INIS)

    Schoots, K.; Jeeninga, H.

    2008-01-01

    The introduction of new technology sometimes proceeds sluggishly due to discontinuity in incentive schemes. Estimating in advance which means are required, what a realistic time span is for the incentive scheme and continuing this scheme until the technology is marketable can significantly increase the success of innovation trajectories. [mk] [nl

  4. Successfully combating prejudice

    Indian Academy of Sciences (India)

    Lawrence

    Sir Jagdish Chandra Bose, and fascinated by his work that showed that plants were ... U.S., in 1972, I was invited to take up a faculty position at the newly established ... success because of their different social commitments. Today when I look ...

  5. Designing for success

    Energy Technology Data Exchange (ETDEWEB)

    Altounyan, P.; Hurt, K.; Bigby, D. [Rock Mechanics Technology, Stanhope Bretby (United Kingdom)

    1999-07-01

    Successful underground coal mining is dependent on a number of key factors, particularly geotechnical suitability. The impact of rock mechanics on underground mine design and mining methods is discussed in this article. Methods on minimising stress effects in room and pillar mining, and longwall mining are outlined. The use of computer numerical modelling in mine design is mentioned. 8 figs.

  6. Distance Education Programs: The Technical Support to Be Successful.

    Science.gov (United States)

    McNew, Ryan E; Gordon, Jeffry S; Weiner, Elizabeth E; Trangenstein, Patricia

    2016-01-01

    Academic success requires support on a variety of levels as well as access to contemporary tools and services. Supporting students enrolled in a successful higher education distance learning program, requires a strong, properly trained IT support staff in addition to a stable IT environment. Our distance education program began with a regional market but has grown significantly over the past few years. This is primarily due to the success of our distance education tools and support which have contributed to achieving a ranking of eleventh of best graduate schools in nursing according to the U.S. News and World Report. The entire student population is "Bring Your Own Devices" (BYOD). Critical to this support is the initial configuration and loading of needed software during the first week of orientation. All of this success requires a robust team of members prepared in a range of skill sets from networking to instructional design.

  7. Rotavirus Vaccines: a story of success with challenges ahead [version 1; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Miguel O’Ryan

    2017-08-01

    Full Text Available Approximately 40 years have passed since the discovery of the rotavirus and 10 years since the introduction and progressive dissemination of rotavirus vaccines worldwide. Currently, 92 countries have introduced rotavirus vaccines into national or subnational programs with evident impact in disease reduction. Two vaccines have been widely used, and four additional vaccines have been licensed and are being used in defined regions. In this context, one main issue that remains unsolved is the lower vaccine efficacy/effectiveness in low-income countries. An additional partially answered issue relates to rotavirus strain circulation in vaccinated populations. These issues are discussed in this review. The most imperative challenge ahead is to fulfill the WHO’s recommendation to introduce rotavirus vaccines in all countries.

  8. Styles of success

    DEFF Research Database (Denmark)

    Dahlgaard, Jens Jørn; Nørgaard, Anders; Jakobsen, Søren

    1997-01-01

    Corporate success stories tend to emphasize the "great men" theory of history. But now a European research project established the managerial attributes that can turn an ordinary leader into one ideal for the pursuit of business excellence. The emergence of five leadership styles as crucial drivers...... of business excellence points to a clear agenda for success. Setting clear strategic goals and the ability to take a long-term view of an organization's direction, combined with other leadership attributes such as creativity, teambuilding and learning, are principal keys to creating an excellent organization....... Leaders seeking to achive business excellence must view the high-level attainment of these sets of leadership competencies as their paramount objective. In striving for business excellence, European leaders may encounter resistance among their employees. Crucially, European employees place a markedly...

  9. Small(pox) success?

    Science.gov (United States)

    Birn, Anne-Emanuelle

    2011-02-01

    The 30th anniversary of the World Health Organization's (WHO) official certification of smallpox eradication was marked by a slew of events hailing the campaign's dramatic tale of technological and organizational triumph against an ancient scourge. Yet commemorations also serve as moments of critical reflection. This article questions the acclaim showered upon smallpox eradication as the single greatest public health success in history. It examines how and why smallpox eradication and WHO's concurrent social justice-oriented primary health care approach (following from the Declaration of Alma-Ata) became competing paradigms. It synthesizes critiques of eradication's shortcomings and debunks some of the myths surrounding the global eradication campaign as a public health priority and necessity, and as a Cold War victory of cooperation. The article concludes with thoughts on integrating technical and social-political aspects of health within the context of welfare states as the means to achieving widespread and enduring global public health success.

  10. Small(pox success?

    Directory of Open Access Journals (Sweden)

    Anne-Emanuelle Birn

    Full Text Available The 30th anniversary of the World Health Organization's (WHO official certification of smallpox eradication was marked by a slew of events hailing the campaign's dramatic tale of technological and organizational triumph against an ancient scourge. Yet commemorations also serve as moments of critical reflection. This article questions the acclaim showered upon smallpox eradication as the single greatest public health success in history. It examines how and why smallpox eradication and WHO's concurrent social justice-oriented primary health care approach (following from the Declaration of Alma-Ata became competing paradigms. It synthesizes critiques of eradication's shortcomings and debunks some of the myths surrounding the global eradication campaign as a public health priority and necessity, and as a Cold War victory of cooperation. The article concludes with thoughts on integrating technical and social-political aspects of health within the context of welfare states as the means to achieving widespread and enduring global public health success.

  11. Profile of success

    DEFF Research Database (Denmark)

    Dahlgaard, Jens Jørn; Nørgaard, Anders; Jakobsen, Søren

    1998-01-01

    What management skills must Europe's business leaders improve to achieve business excellence? Which country's leaders are best placed for success? Does the next generation have what it takes to compete? In the second half of their study of the leadership styles that drive business excellence, Jens...... Dahlgaard, Anders Nørgaard and Søren Jakobsen describe an excellent leadership profile that provides the answers....

  12. Successful time management

    CERN Document Server

    Forsyth, Patrick

    2016-01-01

    Packed with tips and techniques, Successful Time Management serves as a guide to reviewing and assessing new work practices to improve time management. It includes great time-saving ideas, practical solutions, checklists, and advice on controlling paperwork, delegating and working with others, prioritizing to focus on key issues, and getting and staying organized. This new third edition contains new practical tips on using email in a time effective manner and dealing with other internet-based tools and apps to help productivity.

  13. Hypopituitarism and successful pregnancy

    OpenAIRE

    Du, Xue; Yuan, Qing; Yao, Yanni; Li, Zengyan; Zhang, Huiying

    2014-01-01

    Hypopituitarism is a disorder characterized by the deficiency of one or more of the hormones secreted by the pituitary gland. Hypopituitarism patients may present the symptoms of amenorrhea, poor pregnancy potential, infertility, and no production of milk after delivery. Successful pregnancy in hypopituitarism patient is rare because hypopituitarism is associated with an increased risk of pregnancy complications, such as abortion, anemia, pregnancy-induced hypertension, placental abruption, p...

  14. 40 CFR 52.2352 - Change to approved plan.

    Science.gov (United States)

    2010-07-01

    ... Utah's approved State Implementation Plan (SIP). This rule language pertains to State Sales Tax... 40 Protection of Environment 4 2010-07-01 2010-07-01 false Change to approved plan. 52.2352... (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS (CONTINUED) Utah § 52.2352 Change to approved...

  15. 78 FR 2315 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2013-01-10

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  16. 78 FR 15402 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2013-03-11

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  17. 78 FR 11947 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2013-02-20

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  18. 78 FR 17281 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2013-03-20

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  19. 77 FR 16317 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-03-20

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  20. 77 FR 66909 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-11-07

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule... below, receiving approval for the consumptive use of water pursuant to the Commission's approval by rule...

  1. 77 FR 21143 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-04-09

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  2. 77 FR 25010 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-04-26

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule... below, receiving approval for the consumptive use of water pursuant to the Commission's approval by rule...

  3. 77 FR 34455 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-06-11

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  4. 77 FR 55891 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-09-11

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  5. 77 FR 55892 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-09-11

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  6. 77 FR 59239 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-09-26

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule..., receiving approval for the consumptive use of water pursuant to the Commission's approval by rule process...

  7. Methotrexate for the treatment of juvenile idiopathic arthritis: process to approval for JIA indication in Japan.

    Science.gov (United States)

    Mori, Masaaki; Naruto, Takuya; Imagawa, Tomoyuki; Murata, Takuji; Takei, Syuji; Tomiita, Minako; Itoh, Yasuhiko; Fujikawa, Satoshi; Yokota, Shumpei

    2009-01-01

    Methotrexate (MTX), the primary treatment for the articular-type juvenile idiopathic arthritis (JIA), is effective and brings about radiological improvement. Patient compliance is good, and it is recognized that its known side effects, namely, disruption of liver function and induction of pulmonary lesions, are unlikely to be severe at the low MTX doses that are administered. In Japan, MTX was granted approval in 1999 by the then Ministry of Health and Welfare specifically for treating rheumatoid arthritis in adult patients, allowing it be generally used in medical institutions for patients having National Health Insurance. However, in the pediatric field, its use outside the indications has so far been unavoidable, and has been left to the discretion of the physician. Finally, at the present conference, expansion of the indications of MTX for JIA was approved in Japan. It is noteworthy that this expansion of indications was achieved without requiring clinical trials on children sponsored by the pharmaceutical company: it was achieved rather by collecting necessary information through ongoing efforts (including collection and analysis of information about approval status in foreign countries, adequate evidence from the literature, implementation of a clinical use survey in Japan, etc.). It also merits attention that the maximum dose (10 mg/m2) was set on the basis of pharmacokinetic data from children, rather than relying on the dosing method and dose for adults.

  8. Bringing Terra Science to the People: 10 years of education and public outreach

    Science.gov (United States)

    Riebeek, H.; Chambers, L. H.; Yuen, K.; Herring, D.

    2009-12-01

    The default image on Apple's iPhone is a blue, white, green and tan globe: the Blue Marble. The iconic image was produced using Terra data as part of the mission's education and public outreach efforts. As far-reaching and innovative as Terra science has been over the past decade, Terra education and public outreach efforts have been equally successful. This talk will provide an overview of Terra's crosscutting education and public outreach projects, which have reached into educational facilities—classrooms, museums, and science centers, across the Internet, and into everyday life. The Earth Observatory web site was the first web site designed for the public that told the unified story of what we can learn about our planet from all space-based platforms. Initially conceived as part of Terra mission outreach in 1999, the web site has won five Webby awards, the highest recognition a web site can receive. The Visible Earth image gallery is a catalogue of NASA Earth imagery that receives more than one million page views per month. The NEO (NASA Earth Observations) web site and WMS (web mapping service) tool serves global data sets to museums and science centers across the world. Terra educational products, including the My NASA Data web service and the Students' Cloud Observations Online (S'COOL) project, bring Terra data into the classroom. Both projects target multiple grade levels, ranging from elementary school to graduate school. S'COOL uses student observations of clouds to help validate Terra data. Students and their parents have puzzled over weekly "Where on Earth" geography quizzes published on line. Perhaps the most difficult group to reach is the large segment of the public that does not seek out science information online or in a science museum or classroom. To reach these people, EarthSky produced a series of podcasts and radio broadcasts that brought Terra science to more than 30 million people in 2009. Terra imagery, including the Blue Marble, have

  9. Bringing Antarctic Weddell seals to the classroom through PolarTREC

    Science.gov (United States)

    Eilers, A. A.

    2017-12-01

    PolarTREC (Teachers and Researchers Exploring and Collaborating) is an NSF funded professional development opportunity in which K-12 teachers and informal educators participated in hands-on field research experiences in the Polar Regions. The program goal is to invigorate polar science education and understanding by bringing together educators and polar researchers. This unique opportunity for educators has two main components: a 4-6 week field experience and a classroom/community connection piece. In preparation for these experiences, museum educator Alex Eilers and science team lead Dr. Jennifer Burns planned, developed and executed extensive outreach efforts for both students and the community to highlight the Weddell seal research project during the 2012, 2014 and 2016 seasons. The following outreach activities summarize the team's most successful attempts at engaging schoolchildren, teachers and the public, creating a broader impact of the Weddell seal scientific project. On-line Daily journal entries were uploaded to the PolarTREC website encouraging an active interaction between the science team and participants. A Polar Connect event offered participants a real-time, interactive internet presentation with the team. Schools A multitude of on-site presentations were made in classrooms, at teacher workshops and faculty meetings. Two 45 minute labs were developed for students visiting the museum, Animals of the Antarctic and Journey to the Poles, the latter is now included in our ongoing program repertoire. Two travelling kits, Extreme Cold Weather Gear and The Weddell Seal, were developed by museum staff and continue to circulate through schools. A multi-lesson educational module was developed by museum staff to bridge the gap between the scientific research conducted in the field and students in grades 3-8. It contains curriculum-based lessons, field data and strategic methods to assist students in analyzing the data. Community Community-wide interest

  10. Successful innovation by motivation

    Directory of Open Access Journals (Sweden)

    Petra Koudelková

    2015-10-01

    Full Text Available Innovation is one of the most important factors for business growth. Human capital plays a significant role in the successful process of innovation. This article deals with employee motivation in the innovation process and the main scientific aim of this study is to present results of research that was undertaken in the Czech Republic at the beginning of 2013. Questionnaires were used for the survey and statistical analyses such as Chi square test or Hierarchical cluster analysis were used for data processing. This study also provides a theoretical and practical overview of business innovation in the Czech Republic.

  11. Radiological Medical Device Innovation: Approvals via the Premarket Approval Pathway From 2000 to 2015.

    Science.gov (United States)

    Ghobadi, Comeron W; Hayman, Emily L; Finkle, Joshua H; Walter, Jessica R; Xu, Shuai

    2017-01-01

    The aim of this study was to critically assess the clinical evidence leading to radiologic medical device approvals via the premarket approval pathway from 2000 to 2015. This study used the publically available FDA premarket database for radiologic device approvals over the past 15 years (September 1, 2000, to August 31, 2015). Approval characteristics were collected for each device, and statistical analysis was performed on the data for each pivotal trial. Additionally, methodological quality of the pivotal trial was determined using the Quality Assessment of Diagnostic Accuracy Studies tool. Twenty-three class III radiologic device approvals were identified, with breast imaging accounting for 16 (70%) and computer-aided detection software accounting for 9 (39%) approvals. The median premarket approval time was 475 days (range, 180-1,116). Twenty-one devices were approved on the basis of multireader, multicenter studies, one on the basis of a randomized controlled trial, and one on the basis of a preclinical technical equivalence trial. The median number of patients per pivotal trial was 201 (range, 25-3,946). Twenty-six of the 34 pivotal trials (76%) had at least one methodologic bias. Breast imaging devices had a greater number of patients per pivotal trial (P = .009) and more prospective studies. With regard to all modalities, increased time to device approval correlated with weaker trial quality (r = 0.600, P assessing diagnostic technologies. Given that radiologic devices play a key role in modern medicine, further efforts should be made to increase transparency of clinical data leading to approval. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  12. Undisciplined beginnings, academic success, and discursive psychology.

    Science.gov (United States)

    Billig, Michael

    2012-09-01

    This paper reflects on the conditions under which Discourse and social psychology, Common knowledge, and the author's Arguing and thinking were written. These books, which were independently conceived, were not specifically written as contributions to 'discursive psychology', for discursive psychology did not exist at that time. Their authors were rejecting conventional approaches to doing psychological research. The paper discusses what it takes for a new academic movement, such as discursive psychology, to be successfully established in the current climate of 'academic capitalism'. Two requirements are particularly mentioned: the necessity for a label and the necessity for adherents to be recruited. Of the three books, only Discourse and social psychology was outwardly recruiting its readers to a new way of doing social psychology. Arguing and thinking, with its celebration of ancient rhetoric, was much more ambiguous in its aims. It was turning away from present usefulness towards the past. By claiming to be 'an antiquarian psychologist' the author was rejecting disciplinary thinking. The paper also considers the intellectual costs of establishing a new specialism or sub-discipline. The 'first generation' may have freedom, but success can bring about a narrowing of perspectives and the development of orthodoxies for subsequent academic generations. This applies as much to the development of experimental social psychology as to discursive psychology. These processes are particular enhanced in the present socio-economic situation of contemporary universities, which make it more difficult for young academics to become, in the words of William James, 'undisciplinables'. ©2012 The British Psychological Society.

  13. European projects: a new wave of success

    CERN Document Server

    2011-01-01

    Since the beginning of this year, no fewer than six new EU projects at CERN have been launched. These are just a third of the projects selected by the European Commission for funding during the course of 2010, bringing in some 23 M€ over a period of two to five years. This makes last year our most successful yet in securing EU support, and places CERN among the top 50 out of more than 10,000 participants in the EU’s seventh Framework Programme.   The success rate of our proposals has been very good ever since the beginning of FP7 in 2007, particularly for projects coordinated by CERN. There has been a clear evolution of CERN’s involvement in EU projects over the last 10 years. In the early days, we tended to target the Marie Curie actions and the e-Infrastructures Programme. The former help us to fulfil our mission to train young people, while the latter supported the development of the European Grid, mainly through the EGEE projects. Later, the Organization became a...

  14. The Engaged Microbiologist: Bringing the Microbiological Sciences to the K-12 Community.

    Science.gov (United States)

    Westenberg, David J

    2016-03-01

    Exposing K-12 students to cutting edge science that impacts their daily lives can bring classroom lessons to life. Citizen-science projects are an excellent way to bring high-level science to the classroom and help satisfy one of the cornerstone concepts of the Next Generation Science Standards (NGSS), "engaging in practices that scientists and engineers actually use." This can be a daunting task for teachers who may lack the background or resources to integrate these projects into the classroom. This is where scientific societies such as the American Society for Microbiology (ASM) can play a critical role. ASM encourages its members to engage with the K-12 community by providing networking opportunities and resources for ASM members and K-12 teachers to work together to bring microbiology into the classroom. Journal of Microbiology & Biology Education.

  15. Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators.

    Science.gov (United States)

    Bohl, Casey E; Wu, Zengru; Chen, Jiyun; Mohler, Michael L; Yang, Jun; Hwang, Dong Jin; Mustafa, Suni; Miller, Duane D; Bell, Charles E; Dalton, James T

    2008-10-15

    Selective androgen receptor modulators (SARMs) are essentially prostate sparing androgens, which provide therapeutic potential in osteoporosis, male hormone replacement, and muscle wasting. Herein we report crystal structures of the androgen receptor (AR) ligand-binding domain (LBD) complexed to a series of potent synthetic nonsteroidal SARMs with a substituted pendant arene referred to as the B-ring. We found that hydrophilic B-ring para-substituted analogs exhibit an additional region of hydrogen bonding not seen with steroidal compounds and that multiple halogen substitutions affect the B-ring conformation and aromatic interactions with Trp741. This information elucidates interactions important for high AR binding affinity and provides new insight for structure-based drug design.

  16. Frontier Fields: A Cost-Effective Approach to Bringing Authentic Science to the Education Community

    Science.gov (United States)

    Eisenhamer, B.; Lawton, B.; Summers, F.; Ryer, H.

    2015-11-01

    For more than two decades, the Hubble EPO program has sought to bring the wonders of the universe to the education community and the public, and to engage audiences in the adventure of scientific discovery. Program components include standards-based, curriculum-support materials, exhibits and exhibit components, and professional development workshops. The main underpinnings of the program's infrastructure are scientist-educator development teams, partnerships, and an embedded program evaluation component. The Space Telescope Science Institute's Office of Public Outreach is leveraging this existing infrastructure to bring the Frontier Fields science program to the education community in a cost-effective way. Frontier Fields observations and results have been, and will continue to be, embedded into existing product lines and professional development offerings. We also are leveraging our new social media strategy to bring the science program to the public in the form of an ongoing blog.

  17. The Engaged Microbiologist: Bringing the Microbiological Sciences to the K–12 Community

    Directory of Open Access Journals (Sweden)

    David J. Westenberg

    2015-12-01

    Full Text Available Exposing K–12 students to cutting edge science that impacts their daily lives can bring classroom lessons to life. Citizen-science projects are an excellent way to bring high-level science to the classroom and help satisfy one of the cornerstone concepts of the Next Generation Science Standards (NGSS, “engaging in practices that scientists and engineers actually use.” This can be a daunting task for teachers who may lack the background or resources to integrate these projects into the classroom. This is where scientific societies such as the American Society for Microbiology (ASM can play a critical role. ASM encourages its members to engage with the K–12 community by providing networking opportunities and resources for ASM members and K–12 teachers to work together to bring microbiology into the classroom.

  18. Ultrasound Collaboration across Europe: An EFSUMB success story in politically troubled times?

    Science.gov (United States)

    Sidhu, P S

    2016-10-01

    In these days of political vagueness, to use a kinder term, although many would describe the situation as turmoil, in Europe, there are success stories to be lauded. Notwithstanding the direction individual countries choose in relation to closer or not so close co-operation in Europe and the direction the political agenda will travel over the next few years, I believe science and in particular medicine has benefited enormously form close co-operation across the European Union and with colleagues outside this political and trading block of nations. Ultrasound within the community of medical scientists and clinicians is a unique imaging tool that links various disparate specialities that collaborate little in any sphere other than imaging with the tool of sonography. An umbrella organization that allows co-operation between the medical specialities, and brings basic scientist under one roof to co-operate closely is undoubted of benefit ultimately with the customer, in this case the patient.The European Federation of Societies of Ultrasound in Medicine and Biology (EFSUMB) has over the last few years in particular achieved this unique position of bringing together peoples from across the European nation in collaboration in numerous projects, using skilled expertise from different nations to forge the common aim of advancing the practice of ultrasound as applied to biology and medicine. The success of this collaboration is demonstrated by the number of guidelines issued by EFSUMB over the years, well received across the globe and respected by numerous citations in the literature. The main areas of expertise has been in the guidelines associated with contrast ultrasound 1 2 and elastography 3 4, but also with guidelines pertaining to interventional ultrasound 5, student education 6 and recently contrast ultrasound in paediatric practice 7. More guidelines are planned, with input from many different experts from societies within the family of EFSUMB. These guidelines set

  19. LEIR commissioning successfully completed

    CERN Multimedia

    2006-01-01

    An important milestone has been passed in the preparation of the injector complex to supply ions to the LHC experiments. The LEIR lead-ion beam, seen on one of the control screens just before the PS injection region. The Low-Energy Ion Ring - LEIR for short - has passed its first tests with flying colours. On 12 May, the ring that will accumulate lead ions for the LHC was shut down after seven months of tests (see Bulletin 44/2005). 'The commissioning phase was a resounding success,' enthuses a satisfied Michel Chanel, head of the LEIR construction project. After several months of fine-tuning, the LEIR team has achieved its aim of producing the kind of beam required for first lead-ion collisions in the LHC in 2008. This involved creating bunches containing 230 million ions, in line with the specifications for those first beams. This success can be put down to the machine's outstanding design and components. 'It's a great achivement by all the teams involved in the machine's construction,' underlines Christian...

  20. Data Redistribution through MY NASA DATA: Striving to bring authentic NASA data into education

    Science.gov (United States)

    Lewis, P. M.; Oostra, D.; Oots, P.; Chambers, L. H.; Moore, S.; Crecelius, S.; Taylor, J.

    2012-12-01

    The Mentoring and inquirY using NASA Data on Atmospheric and Earth science for Teachers and Amateurs (MY NASA DATA or MND) project was launched in 2004 to bring authentic data into K-12 education. The MND website features a Live Access Server (LAS), an open source tool which allows users to customize data sets to suit their individual needs, choosing from among 200 global Level 3 data sets. Approximately 120 lesson plans that utilize the available parameters are offered to help teachers and students get started with data exploration. Grade appropriate data documentation is also provided (with continual efforts to improve it to better meet the needs of this target audience). Through inquiry and lesson utilization, educators have several connection points to the data. As classrooms shift to problem-based and inquiry learning, the need for a data visualizer/server increases. Through numerous and growing connections to NASA satellite missions, and with access to data as a built-in feature, MND effectively fills this niche to provide a first level of data re-use that is friendly to the K-12 community. Offering a wide variety of data sets allows MND to support many science topics within the K-12 curriculum while extending the use of scientific data from NASA Earth science satellites. Lessons, created by educators across the country, allow MND to connect with the classroom teacher and to meet their data needs. As technology continues to evolve, a second level of data re-use becomes both interesting and possible. Thus, the MND team is now exploring new web and mobile platforms that can be built and distributed on an accelerated time cycle to keep up with information technology developments. With implementation of these new platforms come challenges in promoting new items to the education community, the public, and other potential users. Included in the list of challenges are: ever-evolving technology, prediction of the market, web/mobile platforms, and time-to-market for

  1. Approaches to facilitate institutional review board approval of multicenter research studies.

    Science.gov (United States)

    Marsolo, Keith

    2012-07-01

    Gaining Institutional Review Board (IRB) approval for a multicenter research study can be a lengthy and time-consuming process. It can increase the complexity of consent forms, decreasing patient understanding and lowering recruitment numbers. It also leads to increased costs through the duplication of effort. This paper examines some of the strategies used to streamline the IRB review process for multicenter studies and provides examples used by 2 existing multicenter comparative effectiveness research networks. A literature search was conducted to identify sources that described the challenges and potential strategies to facilitate multicenter IRB approval. The most promising avenues were identified and included in this review. Phone interviews were conducted with the Principal Investigators and Project Managers of 2 successful multicenter research networks to learn their "keys to success" and their lessons learned. Three strategies were identified that held the most promise: working with IRBs before submission, the use of central and/or federated IRBs, and the establishment of an umbrella protocol. Each of these strategies was used to some degree by the case study projects. Although the approaches documented here can help streamline the IRB approval process, they are not a "silver bullet." Because some of these approaches are still relatively new, empirical data are sparse. However, it is believed that they will significantly reduce the administrative burden of the project as a whole and lead to a decrease in the overall time to protocol approval.

  2. Using the key success factor concept in competitor intelligence and benchmarking

    DEFF Research Database (Denmark)

    Bisp, Søren; Sørensen, Elin; Grunert, Klaus G.

    1997-01-01

    A key success factor is regarded as a skill or a resource that a business can invest in, which explains a major part of the observable differences in perceived value of the offer and/or relative costs of bringing that offer to the marketplace. Key success factors are potentially useful in structu......A key success factor is regarded as a skill or a resource that a business can invest in, which explains a major part of the observable differences in perceived value of the offer and/or relative costs of bringing that offer to the marketplace. Key success factors are potentially useful...... in structuring the generation of market intelligence in competitor analysis and benchmarking. To this end, a method was developed, based on a reverse laddering procedure, which elicits decision-makers' subjec causal maps. When aggregated, these maps can be used to derive competitor analysis systems. The paper...

  3. LHC synchronization test successful

    CERN Multimedia

    The synchronization of the LHC's clockwise beam transfer system and the rest of CERN's accelerator chain was successfully achieved last weekend. Tests began on Friday 8 August when a single bunch of a few particles was taken down the transfer line from the SPS accelerator to the LHC. After a period of optimization, one bunch was kicked up from the transfer line into the LHC beam pipe and steered about 3 kilometres around the LHC itself on the first attempt. On Saturday, the test was repeated several times to optimize the transfer before the operations group handed the machine back for hardware commissioning to resume on Sunday. The anti-clockwise synchronization systems will be tested over the weekend of 22 August.Picture:http://lhc-injection-test.web.cern.ch/lhc-injection-test/

  4. Iridium: failures & successes

    Science.gov (United States)

    Christensen, CarissaBryce; Beard, Suzette

    2001-03-01

    This paper will provide an overview of the Iridium business venture in terms of the challenges faced, the successes achieved, and the causes of the ultimate failure of the venture — bankruptcy and system de-orbit. The paper will address technical, business, and policy issues. The intent of the paper is to provide a balanced and accurate overview of the Iridium experience, to aid future decision-making by policy makers, the business community, and technical experts. Key topics will include the history of the program, the objectives and decision-making of Motorola, the market research and analysis conducted, partnering strategies and their impact, consumer equipment availability, and technical issues — target performance, performance achieved, technical accomplishments, and expected and unexpected technical challenges. The paper will use as sources trade media and business articles on the Iridium program, technical papers and conference presentations, Wall Street analyst's reports, and, where possible, interviews with participants and close observers.

  5. Decommissioning. Success with preparation

    International Nuclear Information System (INIS)

    Klasen, Joerg; Schulz, Rolf; Wilhelm, Oliver

    2017-01-01

    The decommissioning of a nuclear power plant poses a significant challenge for the operating company. The business model is turned upside down and a working culture developed for power operation has to be adapted while necessary know- how for the upcoming tasks has to be built up. The trauma for the employees induced by the final plant shut-down has to be considered and respected. The change of working culture in the enterprise has to be managed and the organization has to be prepared for the future. Here the methods of Change-Management offer a systematic and effective approach. Confidence in the employee's competencies is one of the key success factors for the change into the future.

  6. Success in geothermal development

    International Nuclear Information System (INIS)

    Stefansson, V.

    1992-01-01

    Success in geothermal development can be defined as the ability to produce geothermal energy at compatible energy prices to other energy sources. Drilling comprises usually the largest cost in geothermal development, and the results of drilling is largely influencing the final price of geothermal energy. For 20 geothermal fields with operating power plants, the ratio between installed capacity and the total number of well in the field is 1.9 MWe/well. The drilling history in 30 geothermal fields are analyzed by plotting the average cumulative well outputs as function of the number of wells drilled in the field. The range of the average well output is 1-10 MWe/well with the mean value 4.2 MWe/well for the 30 geothermal fields studied. A leaning curve is defined as the number of wells drilled in each field before the average output per well reaches a fairly constant value, which is characteristic for the geothermal reservoir. The range for this learning time is 4-36 wells and the average is 13 wells. In general, the average well output in a given field is fairly constant after some 10-20 wells has been drilled in the field. The asymptotic average well output is considered to be a reservoir parameter when it is normalized to the average drilling depth. In average, this reservoir parameter can be expressed as 3.3 MWe per drilled km for the 30 geothermal fields studied. The lifetime of the resource or the depletion time of the geothermal reservoir should also be considered as a parameter influencing the success of geothermal development. Stepwise development, where the reservoir response to the utilization for the first step is used to determine the timing of the installment of the next step, is considered to be an appropriate method to minimize the risk for over investment in a geothermal field

  7. Colour for Behavioural Success

    Science.gov (United States)

    Reeves, Adam

    2018-01-01

    Colour information not only helps sustain the survival of animal species by guiding sexual selection and foraging behaviour but also is an important factor in the cultural and technological development of our own species. This is illustrated by examples from the visual arts and from state-of-the-art imaging technology, where the strategic use of colour has become a powerful tool for guiding the planning and execution of interventional procedures. The functional role of colour information in terms of its potential benefits to behavioural success across the species is addressed in the introduction here to clarify why colour perception may have evolved to generate behavioural success. It is argued that evolutionary and environmental pressures influence not only colour trait production in the different species but also their ability to process and exploit colour information for goal-specific purposes. We then leap straight to the human primate with insight from current research on the facilitating role of colour cues on performance training with precision technology for image-guided surgical planning and intervention. It is shown that local colour cues in two-dimensional images generated by a surgical fisheye camera help individuals become more precise rapidly across a limited number of trial sets in simulator training for specific manual gestures with a tool. This facilitating effect of a local colour cue on performance evolution in a video-controlled simulator (pick-and-place) task can be explained in terms of colour-based figure-ground segregation facilitating attention to local image parts when more than two layers of subjective surface depth are present, as in all natural and surgical images. PMID:29770183

  8. Politics and the success of school-based health centers.

    Science.gov (United States)

    Rienzo, B A; Button, J W; Wald, K D

    2000-10-01

    School-based health centers (SBHCs) provide access to health services by bringing providers to children (and sometimes parents) and furnishing low cost services in an atmosphere of trust. While the number of SBHCs has continued to grow and some clinics have continued to expand their services, others have barely survived and some have even closed. This study investigated factors, particularly political forces, that affected the success of SBHCs. Using a national survey of clinic directors, this study assessed clinic success in terms both of longevity and service delivery. Findings indicate the factors most consistently and significantly associated with success include not only measures of "need" (school size and percent African-American enrollment or population) but of "politics" (citizen political ideology and Southern conservatism). Thus, politics matters more than previous studies suggested.

  9. Success with voice recognition.

    Science.gov (United States)

    Sferrella, Sheila M

    2003-01-01

    You need a compelling reason to implement voice recognition technology. At my institution, the compelling reason was a turnaround time for Radiology results of more than two days. Only 41 percent of our reports were transcribed and signed within 24 hours. In November 1998, a team from Lehigh Valley Hospital went to RSNA and reviewed every voice system on the market. The evaluation was done with the radiologist workflow in mind, and we came back from the meeting with the vendor selection completed. The next steps included developing a business plan, approval of funds, reference calls to more than 15 sites and contract negotiation, all of which took about six months. The department of Radiology at Lehigh Valley Hospital and Health Network (LVHHN) is a multi-site center that performs over 360,000 procedures annually. The department handles all modalities of radiology: general diagnosis, neuroradiology, ultrasound, CT Scan, MRI, interventional radiology, arthography, myelography, bone densitometry, nuclear medicine, PET imaging, vascular lab and other advanced procedures. The department consists of 200 FTEs and a medical staff of more than 40 radiologists. The budget is in the $10.3 million range. There are three hospital sites and four outpatient imaging center sites where services are provided. At Lehigh Valley Hospital, radiologists are not dedicated to one subspecialty, so implementing a voice system by modality was not an option. Because transcription was so far behind, we needed to eliminate that part of the process. As a result, we decided to deploy the system all at once and with the radiologists as editors. The planning and testing phase took about four months, and the implementation took two weeks. We deployed over 40 workstations and trained close to 50 physicians. The radiologists brought in an extra radiologist from our group for the two weeks of training. That allowed us to train without taking a radiologist out of the department. We trained three to six

  10. Montana Advanced Biofuels Great Falls Approval

    Science.gov (United States)

    This November 20, 2015 letter from EPA approves the petition from Montana Advanced Biofuels, LLC, Great Falls facility, regarding ethanol produced through a dry mill process, qualifying under the Clean Air Act for advanced biofuel (D-code 5) and renewable

  11. Reflections on the Ethics-Approval Process

    Science.gov (United States)

    Murray, Lee; Pushor, Debbie; Renihan, Pat

    2012-01-01

    It is sometimes a difficult journey receiving ethics approval for research involving vulnerable populations, research involving our own children, or innovative research methodologies such as autoethnography. This autoethnographical account is a story about one student who wanted to write a PhD dissertation in a very different way and also the…

  12. Drugs@FDA: FDA Approved Drug Products

    Science.gov (United States)

    ... Cosmetics Tobacco Products Home Drug Databases Drugs@FDA Drugs@FDA: FDA Approved Drug Products Share Tweet Linkedin Pin it More sharing ... Download Drugs@FDA Express for free Search by Drug Name, Active Ingredient, or Application Number Enter at ...

  13. 15 CFR 1150.3 - Approved markings.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Approved markings. 1150.3 Section 1150.3 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued... permanently affixed to the exterior surface of the barrel, covering the circumference of the barrel from the...

  14. The Ethics and Politics of Ethics Approval

    Science.gov (United States)

    Battin, Tim; Riley, Dan; Avery, Alan

    2014-01-01

    The regulatory scope of Human Research Ethics Committees can be problematic for a variety of reasons. Some scholars have argued the ethics approval process, for example, is antithetical to certain disciplines in the humanities and social sciences, while others are willing to give it qualified support. This article uses a case study to cast the…

  15. 7 CFR 1425.4 - Approval.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS COOPERATIVE MARKETING ASSOCIATIONS § 1425.4 Approval. (a) For a cooperative to gain CMA status to participate in a marketing assistance loan or Loan deficiency... prepared in accordance with generally accepted accounting principles; (3) A copy of the articles of...

  16. 7 CFR 966.124 - Approved receiver.

    Science.gov (United States)

    2010-01-01

    ... limited to, the following information: (1) Name, address, contact person, telephone number, and e-mail... 7 Agriculture 8 2010-01-01 2010-01-01 false Approved receiver. 966.124 Section 966.124 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements...

  17. Approval Plans in ARL Libraries. Kit 83.

    Science.gov (United States)

    Leonhardt, Thomas W.

    Materials in this collection were submitted by respondents to a survey which sought specific data on the numbers and types of approval plans in Association of Research Libraries (ARL) libraries, whether such plans are meeting expectations, their relative importance in the library, who makes the key decisions, and the kind of thought and study that…

  18. Neratinib Approved for HER2+ Breast Cancer.

    Science.gov (United States)

    2017-09-01

    The FDA approved the tyrosine kinase inhibitor neratinib for extended adjuvant treatment of early-stage HER2-positive breast cancer. The decision adds another treatment option to help prevent recurrence, but its relatively small potential benefit must be weighed against the risk of serious side effects. ©2017 American Association for Cancer Research.

  19. 50 CFR 223.207 - Approved TEDs.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Approved TEDs. 223.207 Section 223.207 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Restrictions Applicable to Threatened Marine and Anadromous Specie...

  20. 7 CFR 1427.10 - Approved storage.

    Science.gov (United States)

    2010-01-01

    ... § 1427.10 Approved storage. (a) Eligible cotton may be pledged as collateral for loans only if stored at... receipt for any bale or bales of cotton pledged as collateral for a CCC loan must include the dates that... cotton pledged as collateral for a CCC loan that are stored outside, and (ii) Through their electronic...

  1. 40 CFR 52.2522 - Approval status.

    Science.gov (United States)

    2010-07-01

    ... plant, Monongahela Power Co. (b) The Administrator hereby extends the interim limitation of 5.12 lbs. SO2 per million BTU for the Harrison power plant until a permanent emission limitation is approved. (c...-10 NAAQS. (h) EPA disapproves the portion of 45 CSR 13 subsection 1 referencing major stationary...

  2. 9 CFR 317.4 - Labeling approval.

    Science.gov (United States)

    2010-01-01

    ... undue economic hardship; and (iv) An unfair competitive advantage would not result from the granting of... Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... approval to the Food Labeling Division, Regulatory Programs, Food Safety and Inspection Service, and...

  3. Bringing Together Interactive Digital Storytelling with Tangible Interaction : Challenges and Opportunities

    NARCIS (Netherlands)

    Catala, Alejandro; Theune, Mariët; Sylla, Cristina; Ribeiro, Pedro; Nunes, Nuno; Oakley, Ian; Nisi, Valentina

    2017-01-01

    This workshop aims to explore challenges and potential opportunities in bringing interactive digital storytelling into the realm of tangible and embodied interaction. To this end, experts from both fields are invited to present and discuss their ideas. Besides fostering discussion and potential

  4. Bringing back the book through digital experiences: e-Books and ...

    African Journals Online (AJOL)

    Bringing back the book through digital experiences: e-Books and digital media as platforms for reading among school children. ... for technology has changed the format of books and reading platforms from print to ereaders. ... print. Findings further showed that there is no significant difference in the attitude of boys and girls ...

  5. Consumer Advertising: Its Role in Bringing a Product to Market. Revised Edition.

    Science.gov (United States)

    Procter and Gamble Educational Services, Cincinnati, OH.

    This kit, designed for high school classes, considers advertising from both consumers' and manufacturers' perspectives. The role of advertising in relation to free enterprise principles is discussed in chapter 1, while chapter 2 provides a history of U.S. advertising processes and development. Chapter 3 describes advertising's role in bringing a…

  6. Bring Back Our Girls, Social Mobilization: Implications for Cross-Cultural Research

    Science.gov (United States)

    Olutokunbo, Adekalu Samuel; Suandi, Turiman; Cephas, Oluwaseyitan Rotimi; Abu-Samah, Irza Hanie

    2015-01-01

    Social mobilization is a proactive measure for community development that salvages the society from destruction and disaster. From sociological perspective, this paper discusses the concept of social mobilization and its implications for cross-cultural research. To do this, the study uses the "Bring Back Our Girls" Global Campaign, as…

  7. Bringing Work Home: Take-Home Pesticide Exposure Among Farm Families

    NARCIS (Netherlands)

    Curwin, B.D.

    2006-01-01

    In this thesis take-home pesticide exposure among farm families, with an emphasis on herbicides, was investigated. Take-home exposure occurs when a worker unwittingly brings home a substance on his or her clothing or shoes, thereby potentially exposing his or her family. The pesticides investigated

  8. Exploring Factors That Influence Technology-Based Distractions in Bring Your Own Device Classrooms

    Science.gov (United States)

    Kay, Robin; Benzimra, Daniel; Li, Jia

    2017-01-01

    Previous research on distractions and the use of mobile devices (personal digital assistants, tablet personal computers, or laptops) have been conducted almost exclusively in higher education. The purpose of the current study was to examine the frequency and influence of distracting behaviors in Bring Your Own Device secondary school classrooms.…

  9. Contingent Commitments: Bringing Part-Time Faculty into Focus. Methodology Supplement

    Science.gov (United States)

    Center for Community College Student Engagement, 2014

    2014-01-01

    Center reporting prior to 2013 focused primarily on descriptive statistics (frequencies and means) of student and faculty behaviors. The goal of the analyses reported here and in "Contingent Commitments: Bringing Part-Time Faculty into Focus" is to understand the engagement of part-time or contingent faculty in various activities that…

  10. Descendit ad [in] inferna:'A matter of no small moment in bringing ...

    African Journals Online (AJOL)

    Descendit ad [in] inferna:'A matter of no small moment in bringing about redemption' ... and make one suspicious about certain ecclesiastical biases. Spatial terms in the Creed should therefore not be demythologised, but rather be transformed in accordance with the insights of the contemporary physics of time and space.

  11. Bring-Your-Own-Device: Turning Cell Phones into Forces for Good

    Science.gov (United States)

    Imazeki, Jennifer

    2014-01-01

    Over the last few years, classroom response systems (or "clickers") have become increasingly common. Although most systems require students to use a standalone handheld device, bring-your-own-device (BYOD) systems allow students to use devices they already own (e.g., a cell phone, tablet or laptop) to submit responses via text message or…

  12. Bringing (Century-Old) Technology into the Classroom. Part I: Teaching Mechanics and Thermodynamics with Antiques

    Science.gov (United States)

    Jewett, John W., Jr.

    2015-01-01

    The notion of bringing technology into the classroom has been the subject of many recent presentations at conferences and papers in physics teaching journals. The use of devices such as laptops, smartphones, tablets, and clickers is rising in today's classrooms and laboratories. PhET simulations have been available online for over a decade. A…

  13. Bringing up condom use and using condoms with new sexual partners : Intentional or habitual?

    NARCIS (Netherlands)

    Yzer, M.C; Siero, F.W.; Buunk, Abraham (Bram)

    2001-01-01

    A prospective study of 94 Dutch adults who have casual sexual partners examined whether two important aspects of safe sex. namely bringing up condom use (BCU) and actual condom use (ACU) are intentional or habitual. For each of these aspects, a model based on the Theory of Planned Behaviour (TPB:

  14. Bringing Adam Smith's Pin Factory to Life: Field Trips and Discussions as Forms of Experiential Learning

    Science.gov (United States)

    Galizzi, Monica

    2014-01-01

    Educators are often aware of the need to implement a variety of teaching techniques to reach out to students with different learning styles. I describe an attempt to target multimodal learners by bringing classical economic texts and concepts to life through discussions, field visits and role playing exercises. In my Labor Economics class I…

  15. Crawl and crowd to bring machine translation to under-resourced languages

    NARCIS (Netherlands)

    Toral Ruiz, Antonio

    2017-01-01

    We present a widely applicable methodology to bring machine translation (MT) to under-resourced languages in a cost-effective and rapid manner. Our proposal relies on web crawling to automatically acquire parallel data to train statistical MT systems if any such data can be found for the language

  16. Data Nuggets: Bringing Real Data into the Classroom to Unearth Students' Quantitative & Inquiry Skills

    Science.gov (United States)

    Schultheis, Elizabeth H.; Kjelvik, Melissa K.

    2015-01-01

    Current educational reform calls for increased integration between science and mathematics to overcome the shortcomings in students' quantitative skills. Data Nuggets (free online resource, http://datanuggets.org) are worksheets that bring data into the classroom, repeatedly guiding students through the scientific method and making claims…

  17. Clickers in the Flipped Classroom: Bring Your Own Device (BYOD) to Promote Student Learning

    Science.gov (United States)

    Hung, Hsiu-Ting

    2017-01-01

    Flipped classrooms continue to grow in popularity across all levels of education. Following this pedagogical trend, the present study aimed to enhance the face-to-face instruction in flipped classrooms with the use of clickers. A game-like clicker application was implemented through a bring your own device (BYOD) model to gamify classroom dynamics…

  18. An Empirical Study towards Understanding User Acceptance of Bring Your Own Device (BYOD) in Higher Education

    Science.gov (United States)

    Cheng, Gary; Guan, Yuanyuan; Chau, Juliana

    2016-01-01

    This paper discusses the findings of a research study investigating user acceptance of bring your own device (BYOD) practice to support teaching and learning in a Hong Kong university. Forty-four undergraduate students and two teachers participated in the study. To collect their ratings of agreement with respect to several BYOD-related issues,…

  19. Bring Your Own Device to Secondary School: The Perceptions of Teachers, Students and Parents

    Science.gov (United States)

    Parsons, David; Adhikar, Janak

    2016-01-01

    This paper reports on the first two years of a Bring Your Own Device (BYOD) initiative in a New Zealand secondary school, using data derived from a series of surveys of teachers, parents and students, who are the main stakeholders in the transformation to a BYOD school. In this paper we analyse data gathered from these surveys, which consists…

  20. Bring Your Own Device (BYOD) and Teacher Pedagogy in a New Zealand Primary School

    Science.gov (United States)

    Rae, Genevieve; Dabner, Nicki; Mackey, Julie

    2017-01-01

    The practice of students bringing their own mobile devices (BYOD) to school is increasingly being used to leverage digital learning opportunities in New Zealand schools. This paper presents a summary of the findings from a case study that explored the experiences of three primary school teachers as they introduced BYOD into their classrooms for…

  1. Bring Your Own Device (BYOD) Programs in the Classroom: Teacher Use, Equity, and Learning Tools

    Science.gov (United States)

    Fincher, Derrel

    2016-01-01

    This study explores teacher perceptions of Bring Your Own Device (BYOD) programs in the classroom, with a focus on teacher use, student equity of access, and student ability to use their devices as learning tools. While one-to-one laptop programs (students assigned identical school-owned laptop or tablet) has an extensive body of literature behind…

  2. Bring Your Own Device--A Snapshot of Two Australian Primary Schools

    Science.gov (United States)

    Maher, Damian; Twining, Peter

    2017-01-01

    Background: The use of 1:1 and Bring Your Own Device strategies in schools is in its infancy and little is known about how mobile devices such as tablets are being used to support educational practice. Purpose: In this article, two suburban primary schools in Sydney, Australia were focused on with an aim to understand how mobile device strategies…

  3. The Power of Questions to Bring Balance to the Curriculum in the Age of New Standards

    Science.gov (United States)

    del Prado, Pixita; McMillen, Susan E.; Friedland, Ellen S.

    2017-01-01

    The Common Core State Standards (CCSS); the Next Generation Science Standards (NGSS); and the College, Career, and Civic Life (C3) Framework for Social State Standards are bringing many changes to schools and classrooms across the United States. This article suggests using the power of questions to make connections across seemingly disparate…

  4. 21 CFR 1005.24 - Costs of bringing product into compliance.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Costs of bringing product into compliance. 1005.24 Section 1005.24 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... include: (a) Travel expenses of the supervising officer; (b) Per diem in lieu of subsistence of the...

  5. Explore: An Action to Bring Science and Technology Closer to Secondary School

    Science.gov (United States)

    Torras-Melenchon, Nuria; Grau, M. Dolors; Font-Soldevila, Josep; Freixas, Josep

    2015-01-01

    This paper presents the experience of an initiative, the EXPLORE courses, designed to bring science and technology closer to secondary school. The EXPLORE courses, organised by "EXPLORATORI: Natural Resources" project, are particularly addressed to secondary school teachers and are conducted at Catalonia (North East of Spain). The main…

  6. Bringing Mohamed to the Mountain: Situated Professional Development in a Ubiquitous Computing Classroom

    Science.gov (United States)

    Swan, Karen; Kratcoski, Annette; Mazzer, Pat; Schenker, Jason

    2005-01-01

    This article describes an ongoing situated professional development program in which teachers bring their intact classes for an extended stay in a ubiquitous computing environment equipped with a variety of state-of-the-art computing devices. The experience is unique in that it not only situates teacher learning about technology integration in…

  7. The Wild-Card Character of "Bring Your Own:" A Panel Discussion

    Science.gov (United States)

    Campbell, W. Gardner; Fitch, Megan; German, Robert F., Jr.; Hulvey, Dale; McIntosh, Keith; McPherson, Michael R.; O'Keefe, John

    2013-01-01

    Panelists on the front lines of higher education information technology share their thoughts on Bring Your Own Device (BYOD) and what it could mean for colleges and universities. Five questions were asked of each panelist. These were: (1) How strategically important to higher education is the BYOD phenomenon? Is it simply a passing fad? (2) Should…

  8. Digital Natives: The Millennial Workforce's Intention to Adopt Bring Your Own Device

    Science.gov (United States)

    Fulton, Joel

    2017-01-01

    Bring your own device (BYOD) is the use of uncontrolled devices, which increases risks to business data and intellectual property. Like centralized and distributed computing adoption before it, the rapid proliferation of BYOD has outstripped security advances. The trend is growing due to the expectations of the Millennial workforce and its high…

  9. Bringing the Tools of Big Science to Bear on Local Environmental Challenges

    Science.gov (United States)

    Bronson, Scott; Jones, Keith W.; Brown, Maria

    2013-01-01

    We describe an interactive collaborative environmental education project that makes advanced laboratory facilities at Brookhaven National Laboratory accessible for one-year or multi-year science projects for the high school level. Cyber-enabled Environmental Science (CEES) utilizes web conferencing software to bring multi-disciplinary,…

  10. 'They bring AIDS to us and say we give it to them': Socio-structural ...

    African Journals Online (AJOL)

    'They bring AIDS to us and say we give it to them': Socio-structural context of female sex workers' vulnerability to HIV infection in Ibadan Nigeria. ... We describe the complex interaction between these themes and how they combine to increase the risk of HIV infection among FSWs. The impact of previous interventions to ...

  11. Constructing target product profiles (TPPs) to help vaccines overcome post-approval obstacles

    OpenAIRE

    Lee, Bruce Y.; Burke, Donald S.

    2009-01-01

    As history has demonstrated, post-approval obstacles can impede a vaccine’s use and potentially lead to its withdrawal. Addressing these potential obstacles when changes in a vaccine’s technology can still be easily made may improve a vaccine’s chances of success. Augmented vaccine target product profiles (TPPs) can help vaccine scientists better understand and anticipate these obstacles and galvanize conversations among various vaccine stakeholders (e.g., scientists, marketers, business deve...

  12. Success and adaptation

    CERN Multimedia

    2013-01-01

    Yesterday morning, the last colliding proton beams of 2013 were extracted from the LHC, heralding the start of the machine’s first long shutdown (LS1) and crowning its first three glorious years of running. I hardly need to tell the CERN community what a fabulous performance all the people running the machine, the experiments, the computing and all supporting infrastructures put in. Those people are you, and you all know very well what a great job everyone did.   Nevertheless, I would like to express my thanks to all the people who made this first LHC run such a success. Re-measuring the whole Standard Model in such a short period, and then completing it with the discovery of what looks increasingly like the Higgs boson, is no mean feat. What I’d like to focus on today is another aspect of our field: its remarkable ability to adapt. When I started out in research, experiments involved a handful of people and lasted a few years at most. The timescale for the development of ...

  13. Assessing call centers’ success:

    Directory of Open Access Journals (Sweden)

    Hesham A. Baraka

    2013-07-01

    This paper introduces a model to evaluate the performance of call centers based on the Delone and McLean Information Systems success model. A number of indicators are identified to track the call center’s performance. Mapping of the proposed indicators to the six dimensions of the D&M model is presented. A Weighted Call Center Performance Index is proposed to assess the call center performance; the index is used to analyze the effect of the identified indicators. Policy-Weighted approach was used to assume the weights with an analysis of different weights for each dimension. The analysis of the different weights cases gave priority to the User satisfaction and net Benefits dimension as the two outcomes from the system. For the input dimensions, higher priority was given to the system quality and the service quality dimension. Call centers decision makers can use the tool to tune the different weights in order to reach the objectives set by the organization. Multiple linear regression analysis was used in order to provide a linear formula for the User Satisfaction dimension and the Net Benefits dimension in order to be able to forecast the values for these two dimensions as function of the other dimensions

  14. Drug lag for cardiovascular drug approvals in India compared with the US and EU approvals

    Directory of Open Access Journals (Sweden)

    Bhaven C. Kataria

    2013-01-01

    Conclusion: This study confirms that there is a substantial drug lag in approval of new cardiovascular drugs in India compared with the United States and European Union. The impact of drug lag on health outcomes remains to be established.

  15. 30 CFR 18.81 - Field modification of approved (permissible) equipment; application for approval of modification...

    Science.gov (United States)

    2010-07-01

    ... TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES... having jurisdiction at the mine where such equipment is to be operated stating the modifications which...

  16. Trends in global approvals of biotech crops (1992–2014)

    Science.gov (United States)

    Aldemita, Rhodora R; Reaño, Ian Mari E; Solis, Renando O; Hautea, Randy A

    2015-01-01

    ABSTRACT With the increasing number of genetically modified (GM) events, traits, and crops that are developed to benefit the global population, approval of these technologies for food, feed, cultivation and import in each country may vary depending on needs, demand and trade interest. ISAAA established a GMO Approval Database to document global approvals of biotech crops. GM event name, crops, traits, developer, year of approval for cultivation, food/feed, import, and relevant dossiers were sourced from credible government regulatory websites and biosafety clearinghouses. This paper investigates the trends in GM approvals for food, feed and cultivation based on the number of approving countries, GM crops, events, and traits in the last 23 y (1992–2014), rationale for approval, factors influencing approvals, and their implications in GM crop adoption. Results show that in 2014, there was an accumulative increase in the number of countries granting approvals at 29 (79% developing countries) for commercial cultivation and 31 (70% developing countries) for food and 19 (80% developing developing) for feed; 2012 had the highest number of approving countries and cultivation approvals; 2011 had the highest number of country approvals for feed, and 2014 for food approvals. Herbicide tolerance trait had the highest events approved, followed by insect tolerance traits. Approvals for food product quality increased in the second decade. Maize had the highest number of events approved (single and stacked traits), and stacked traits product gradually increased which is already 30% of the total trait approvals. These results may indicate understanding and acceptance of countries to enhance regulatory capability to be able to benefit from GM crop commercialization. Hence, the paper provided information on the trends on the growth of the GM crop industry in the last 23 y which may be vital in predicting future GM crops and traits. PMID:26039675

  17. Trends in global approvals of biotech crops (1992-2014).

    Science.gov (United States)

    Aldemita, Rhodora R; Reaño, Ian Mari E; Solis, Renando O; Hautea, Randy A

    2015-01-01

    With the increasing number of genetically modified (GM) events, traits, and crops that are developed to benefit the global population, approval of these technologies for food, feed, cultivation and import in each country may vary depending on needs, demand and trade interest. ISAAA established a GMO Approval Database to document global approvals of biotech crops. GM event name, crops, traits, developer, year of approval for cultivation, food/feed, import, and relevant dossiers were sourced from credible government regulatory websites and biosafety clearinghouses. This paper investigates the trends in GM approvals for food, feed and cultivation based on the number of approving countries, GM crops, events, and traits in the last 23 y (1992-2014), rationale for approval, factors influencing approvals, and their implications in GM crop adoption. Results show that in 2014, there was an accumulative increase in the number of countries granting approvals at 29 (79% developing countries) for commercial cultivation and 31 (70% developing countries) for food and 19 (80% developing developing) for feed; 2012 had the highest number of approving countries and cultivation approvals; 2011 had the highest number of country approvals for feed, and 2014 for food approvals. Herbicide tolerance trait had the highest events approved, followed by insect tolerance traits. Approvals for food product quality increased in the second decade. Maize had the highest number of events approved (single and stacked traits), and stacked traits product gradually increased which is already 30% of the total trait approvals. These results may indicate understanding and acceptance of countries to enhance regulatory capability to be able to benefit from GM crop commercialization. Hence, the paper provided information on the trends on the growth of the GM crop industry in the last 23 y which may be vital in predicting future GM crops and traits.

  18. Approved Drug Products with Therapuetic Equivalence Evaluations (Orange Book)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The publication Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book) identifies drug products approved on...

  19. 7 CFR 1710.105 - State regulatory approvals.

    Science.gov (United States)

    2010-01-01

    ... and Basic Policies § 1710.105 State regulatory approvals. (a) In States where a borrower is required... loans are approved by RUS: (1) Loans requiring an Environmental Impact Statement; (2) Loans to finance...

  20. 27 CFR 4.50 - Certificates of label approval.

    Science.gov (United States)

    2010-04-01

    ..., DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF WINE Requirements for Approval of Labels of... of exemption from label approval, as well as appeal procedures, see part 13 of this chapter. [T.D...

  1. 22 CFR 96.63 - Renewal of accreditation or approval.

    Science.gov (United States)

    2010-04-01

    ... for renewal in a timely fashion. Before deciding whether to renew the accreditation or approval of an... accrediting entity or the Secretary during its most current accreditation or approval cycle, the accrediting...

  2. Clone of EPA Approved Regulations in the Texas SIP

    Science.gov (United States)

    changed name to EPA Approved Regulations in the Texas SIP, Add links to:Texas Read Me; Texas SIP History;Current/Previous SIP-Approved Regulations; Delete regulations--now in /node/191099, removed tables

  3. Auditing Marketing Strategy Implementation Success

    OpenAIRE

    Herhausen, Dennis; Egger, Thomas; Oral, Cansu

    2014-01-01

    What makes a marketing strategy implementation successful and how can managers measure this success? To answer these questions, we developed a two-step audit approach. First, managers should measure the implementation success regarding effectiveness, efficiency, performance outcomes, and strategic embeddedness. Second, they should explore the reasons that have led to success or failure by regarding managerial, leadership, and environmental traps. Doing so will also provide corrective action p...

  4. 75 FR 56663 - Agency Information Collection (Quarterly Report of State Approving Agency Activities); Activity...

    Science.gov (United States)

    2010-09-16

    ... a currently approved collection. Abstract: VA reimburses State Approving Agencies (SAAs) for expenses incurred in the approval and supervision of education and training programs. SAAs are required to...

  5. The approval mechanism solves the prisoner's dilemma theoretically and experimentally

    OpenAIRE

    Tatsuyoshi Saijo; Yoshitaka Okano; Takafumi Yamakawa

    2015-01-01

    Consider a situation where players in a prisoner's dilemma game can approve or reject the other's choice such as cooperation or defection. If both players approve the other's choice, the outcome is the one they chose, whereas if either one rejects the other's choice, the outcome is the one when both defect, which we name the approval mechanism herein (this is inspired by the Cold War doctrine of mutually assured destruction). Experimentally, we find that the cooperation rate with the approval...

  6. Elimination of white Gaussian noise in arterial phase CT images to bring adrenal tumours into the forefront.

    Science.gov (United States)

    Koyuncu, Hasan; Ceylan, Rahime

    2018-04-01

    Dynamic Contrast-Enhanced Computed Tomography (DCE-CT) is applied to observe adrenal tumours in detail by utilising from the contrast matter, which generally brings the tumour into the forefront. However, DCE-CT images are generally influenced by noises that occur as the result of the trade-off between radiation doses vs. noise. Herein, this situation constitutes a challenge in the achievement of accurate tumour segmentation. In CT images, most of the noises are similar to Gaussian Noise. In this study, arterial phase CT images containing adrenal tumours are utilised, and elimination of Gaussian Noise is realised by fourteen different techniques reported in literature for the achievement of the best denoising process. In this study, the Block Matching and 3D Filtering (BM3D) algorithm typically achieve reliable Peak Signal-to-Noise Ratios (PSNR) and resolves challenges of similar techniques when addressing different levels of noise. Furthermore, BM3D obtains the best mean PSNR values among the first five techniques. BM3D outperforms to other techniques by obtaining better Total Statistical Success (TSS), CPU time and computation cost. Consequently, it prepares clearer arterial phase CT images for the next step (segmentation of adrenal tumours). Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Analysis of successive data sets

    NARCIS (Netherlands)

    Spreeuwers, Lieuwe Jan; Breeuwer, Marcel; Haselhoff, Eltjo Hans

    2008-01-01

    The invention relates to the analysis of successive data sets. A local intensity variation is formed from such successive data sets, that is, from data values in successive data sets at corresponding positions in each of the data sets. A region of interest is localized in the individual data sets on

  8. Analysis of successive data sets

    NARCIS (Netherlands)

    Spreeuwers, Lieuwe Jan; Breeuwer, Marcel; Haselhoff, Eltjo Hans

    2002-01-01

    The invention relates to the analysis of successive data sets. A local intensity variation is formed from such successive data sets, that is, from data values in successive data sets at corresponding positions in each of the data sets. A region of interest is localized in the individual data sets on

  9. 19 CFR 115.55 - Termination of approval.

    Science.gov (United States)

    2010-04-01

    ... vehicle by a major repair or alteration of any of the essential features required in § 115.51. Repairs by... TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL CUSTOMS CONVENTIONS Procedures for Approval of Individual Road Vehicles § 115.55 Termination of approval. Approval of a road...

  10. 30 CFR 75.1108 - Approved conveyor belts.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Approved conveyor belts. 75.1108 Section 75... Fire-Resistant Hydraulic Fluids on Underground Equipment § 75.1108 Approved conveyor belts. (a) Until December 31, 2009 conveyor belts placed in service in underground coal mines shall be: (1) Approved under...

  11. 48 CFR 52.222-16 - Approval of Wage Rates.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Approval of Wage Rates. 52....222-16 Approval of Wage Rates. As prescribed in 22.407(b), insert the following clause: Approval of Wage Rates (FEB 1988) All straight time wage rates, and overtime rates based thereon, for laborers and...

  12. 33 CFR 115.70 - Advance approval of bridges.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Advance approval of bridges. 115... BRIDGES BRIDGE LOCATIONS AND CLEARANCES; ADMINISTRATIVE PROCEDURES § 115.70 Advance approval of bridges. (a) The General Bridge Act of 1946 requires the approval of the location and plans of bridges prior...

  13. 8 CFR 207.6 - Control over approved refugee numbers.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Control over approved refugee numbers. 207... ADMISSION OF REFUGEES § 207.6 Control over approved refugee numbers. Current numerical accounting of approved refugees is maintained for each special group designated by the President. As refugee status is...

  14. 12 CFR 614.4470 - Loans subject to bank approval.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Loans subject to bank approval. 614.4470 Section 614.4470 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM LOAN POLICIES AND OPERATIONS Loan Approval Requirements § 614.4470 Loans subject to bank approval. (a) The following loans...

  15. 49 CFR 1522.109 - TSA review and approval.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false TSA review and approval. 1522.109 Section 1522.109..., DEPARTMENT OF HOMELAND SECURITY SECURITY RULES FOR ALL MODES OF TRANSPORTATION TSA-APPROVED VALIDATION FIRMS AND VALIDATORS TSA-Approved Validation Firms and Validators for the Certified Cargo Screening Program...

  16. 49 CFR 1522.115 - Renewal of TSA approval.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Renewal of TSA approval. 1522.115 Section 1522.115..., DEPARTMENT OF HOMELAND SECURITY SECURITY RULES FOR ALL MODES OF TRANSPORTATION TSA-APPROVED VALIDATION FIRMS AND VALIDATORS TSA-Approved Validation Firms and Validators for the Certified Cargo Screening Program...

  17. 45 CFR 1340.13 - Approval of applications.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Approval of applications. 1340.13 Section 1340.13... NEGLECT PREVENTION AND TREATMENT PROGRAM CHILD ABUSE AND NEGLECT PREVENTION AND TREATMENT Grants to States § 1340.13 Approval of applications. (a) The Commissioner shall approve an application for an award for...

  18. 29 CFR 1952.157 - Changes to approved plan.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) APPROVED STATE PLANS FOR ENFORCEMENT OF STATE STANDARDS North Carolina § 1952.157 Changes to approved plan. (a) Legislation. (1) On March 29, 1994, the Assistant Secretary approved North Carolina's... section 17 of the Act as amended on November 5, 1990. (2) [Reserved] (b) The Voluntary Protection Program...

  19. 46 CFR 188.10-3 - Approved container.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Approved container. 188.10-3 Section 188.10-3 Shipping... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-3 Approved container. This term means a container which is properly labeled, marked and approved by DOT for the commodity which it contains. [CGFR...

  20. 76 FR 66117 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2011-10-25

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule... notice lists the projects, described below, receiving approval for the consumptive use of water pursuant...

  1. 76 FR 53526 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2011-08-26

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule... lists the projects, described below, receiving approval for the consumptive use of water pursuant to the...

  2. 76 FR 42159 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2011-07-18

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule... lists the projects, described below, receiving approval for the consumptive use of water pursuant to the...

  3. 77 FR 4859 - Projects Approved for Consumptive Uses of Water

    Science.gov (United States)

    2012-01-31

    ... SUSQUEHANNA RIVER BASIN COMMISSION Projects Approved for Consumptive Uses of Water AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: This notice lists the projects approved by rule... notice lists the projects, described below, receiving approval for the consumptive use of water pursuant...

  4. 20 CFR 617.22 - Approval of training.

    Science.gov (United States)

    2010-04-01

    .... Perkins Vocational and Applied Technology Education Act, and employers). (i) This means that training is...) Conditions for approval. Training shall be approved for an adversely affected worker if the State agency...) available for an adversely affected worker. (i) This means that for the worker for whom approval of training...

  5. 28 CFR 551.11 - Authority to approve a marriage.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Authority to approve a marriage. 551.11... MISCELLANEOUS Marriages of Inmates § 551.11 Authority to approve a marriage. (a) The Warden may approve the marriage of a federal inmate confined in a federal institution. This authority may not be delegated below...

  6. 7 CFR 1717.609 - RUS approval of general manager.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false RUS approval of general manager. 1717.609 Section... Operational Controls § 1717.609 RUS approval of general manager. (a) If a borrower's mortgage or loan contract... general manager of the borrower's system, such approval is hereby granted provided that the borrower is in...

  7. Credit Risk Management - Loan Approval Process

    Directory of Open Access Journals (Sweden)

    Lulzim Rashiti

    2016-03-01

    Full Text Available The aim of this study is on understanding the international regulations issued by Basel I, Basel II and Basel III to best supervise and manage credit risk management policies. Part of paper will focus on the description and impacts of the regulations and the pivotal importance they play in providing a sound banking system. Credit risk represents another important element that will be analysed considering that it lays the foundation during the loan consideration and approval process. The paper will also explain in detail procedures and responsibilities shared along the process of loan acceptance by a banker. To sum up, the overall process from application to loan approval or denial will be explained pointing out the implications that are faced along the way

  8. Nuclear safety review requirements for launch approval

    International Nuclear Information System (INIS)

    Sholtis, J.A. Jr.; Winchester, R.O.

    1992-01-01

    Use of nuclear power systems in space requires approval which is preceded by extensive safety analysis and review. This careful study allows an informed risk-benefit decision at the highest level of our government. This paper describes the process as it has historically been applied to U.S. isotopic power systems. The Ulysses mission, launched in October 1990, is used to illustrate the process. Expected variations to deal with reactor-power systems are explained

  9. Academic Program Approval and Review Practices

    Directory of Open Access Journals (Sweden)

    Don G. Creamer

    1999-08-01

    Full Text Available This report outlines general and specific processes for both program approval and program review practices found in 50 states and eight foreign countries and regions.  Models that depict these procedures are defined and the strengths and weakness of each are discussed.  Alternatives to current practice by state agencies in the U.S. are described that might provide for greater decentralization of these practices while maintaining institutional accountability.

  10. CISP: Simulation Platform for Collective Instabilities in the BRing of HIAF project

    Science.gov (United States)

    Liu, J.; Yang, J. C.; Xia, J. W.; Yin, D. Y.; Shen, G. D.; Li, P.; Zhao, H.; Ruan, S.; Wu, B.

    2018-02-01

    To simulate collective instabilities during the complicated beam manipulation in the BRing (Booster Ring) of HIAF (High Intensity heavy-ion Accelerator Facility) or other high intensity accelerators, a code, named CISP (Simulation Platform for Collective Instabilities), is designed and constructed in China's IMP (Institute of Modern Physics). The CISP is a scalable multi-macroparticle simulation platform that can perform longitudinal and transverse tracking when chromaticity, space charge effect, nonlinear magnets and wakes are included. And due to its well object-oriented design, the CISP is also a basic platform used to develop many other applications (like feedback). Several simulations, completed by the CISP in this paper, agree with analytical results very well, which shows that the CISP is fully functional now and it is a powerful platform for the further collective instability research in the BRing or other accelerators. In the future, the CISP can also be extended easily into a physics control system for HIAF or other facilities.

  11. Radiation requirements for uranium project approvals

    International Nuclear Information System (INIS)

    Hondros, J.

    2014-01-01

    Uranium mining projects in Australia must receive approval under both state and national laws based on a wide ranging impact assessment of the project. The process may take a number of years and involves multiple levels and parts of government and public consultation and scrutiny. The impact assessment is broad and usually covers; environmental, social, health, public safety and economic aspects. Information provided in the approvals documentation needs to be presented in a credible and understandable manner for all audiences. This means making complex information simpler, while making sure that it maintains its technical integrity. Poorly communicated information, which is overly complex, overly simplified or incomplete, can result in significant delays to the project approval which can potentially impact on project timelines. For uranium projects, along with other projects involving radioactive materials, such as minerals sands and rare earths, radiation and its impacts usually draw a disproportionate amount of both government and public scrutiny compared to other potential impacts and risks. It is therefore of key importance that radiation assessments are properly performed and results clearly presented and communicated with sufficient detail for stakeholders to make informed decisions. It is also important to ensure that the radiation risk is presented in perspective with other risks of the project. This presentation outlines a structure for a radiation impact assessment based on experience from a number of projects in Australia. The structure aims to be clear and simple and ensure the right balance between scientific fact, digestible information and demonstrable competence. (author)

  12. Nurse-Managed Clinics: A Blueprint for Success Using the Covey Framework.

    Science.gov (United States)

    Starck, Patricia L.; And Others

    1995-01-01

    Describes the process from inception to successful operation of a university-based, nurse-managed clinic, based on Covey's seven habits of highly effective people. Includes information on the planning process, financing, political strategies for gaining approval, and ongoing development of services. (JOW)

  13. Can Programming Frameworks Bring Smartphones into the Mainstream of Psychological Science?

    OpenAIRE

    Piwek, Lukasz; Ellis, David A.

    2016-01-01

    Smartphones continue to provide huge potential for psychological science and the advent of novel research frameworks brings new opportunities for researchers who have previously struggled to develop smartphone applications. However, despite this renewed promise, smartphones have failed to become a standard item within psychological research. Here we consider the key issues that continue to limit smartphone adoption within psychological science and how these barriers might be diminishing in li...

  14. The Opportunities and Challenges of Bringing New Metrology Equipment to Market

    Science.gov (United States)

    Perloff, David S.

    2005-09-01

    This paper provides an overview of the economic and technological factors which are driving the demand for new metrology and inspection equipment, the challenges and opportunities facing new companies in bringing such equipment to market, and the funding environment in which new companies must raise capital to finance their efforts. Seven metrology companies and one inspection equipment company that have received first-time venture backing since 2000 are used to illustrate how these specialized businesses are launched and funded.

  15. Organisational Capabilities Required for Enabling Employee Mobility through Bring- Your-Own-Device Concept

    OpenAIRE

    Toperesu, B-Abee; Van Belle, Jean-Paul

    2017-01-01

    Background: Mobile device adoption is on the rise and people are increasingly using mobile devices as a part of their lives. Studies have shown that people can use mobile devices to perform their work duties from anywhere. Organisations are now exploring ways of enabling and supporting mobility for employees’ mobile devices, including BYOD (Bring-Your-Own-Device) policies. Objective: The objective of this study is to identify the main capabilities required for enterprise mobility. Methods/App...

  16. Bringing the field into the classroom: an innovative methodology in global health teaching

    OpenAIRE

    Dr. M H Bryant, MBBS; J Wolff, MD

    2015-01-01

    Background: The practice of global health is difficult to teach from a US-based classroom. Students benefit from experiencing how theory becomes practice in the chaotic environments of under-resourced health programmes in developing countries. We could not take our students to the field during weekly course work, so we designed a course to bring the field to the students. We created innovative partnerships with locally based organisations that implement programmes in developing countries. Eac...

  17. The 'added value' GPs bring to commissioning: a qualitative study in primary care.

    Science.gov (United States)

    Perkins, Neil; Coleman, Anna; Wright, Michael; Gadsby, Erica; McDermott, Imelda; Petsoulas, Christina; Checkland, Kath

    2014-11-01

    The 2012 Health and Social Care Act in England replaced primary care trusts with clinical commissioning groups (CCGs) as the main purchasing organisations. These new organisations are GP-led, and it was claimed that this increased clinical input would significantly improve commissioning practice. To explore some of the key assumptions underpinning CCGs, and to examine the claim that GPs bring 'added value' to commissioning. In-depth interviews with clinicians and managers across seven CCGs in England between April and September 2013. A total of 40 clinicians and managers were interviewed. Interviews focused on the perceived 'added value' that GPs bring to commissioning. Claims to GP 'added value' centred on their intimate knowledge of their patients. It was argued that this detailed and concrete knowledge improves service design and that a close working relationship between GPs and managers strengthens the ability of managers to negotiate. However, responders also expressed concerns about the large workload that they face and about the difficulty in engaging with the wider body of GPs. GPs have been involved in commissioning in many ways since fundholding in the 1990s, and claims such as these are not new. The key question is whether these new organisations better support and enable the effective use of this knowledge. Furthermore, emphasis on experiential knowledge brings with it concerns about representativeness and the extent to which other voices are heard. Finally, the implicit privileging of GPs' personal knowledge ahead of systematic public health intelligence also requires exploration. © British Journal of General Practice 2014.

  18. 75 FR 48302 - Notice of Request for Extension of Approval of an Information Collection; Credit Account Approval...

    Science.gov (United States)

    2010-08-10

    ....gov ). FOR FURTHER INFORMATION CONTACT: For information on credit account approval for reimbursable..., at (301) 851-2908. SUPPLEMENTARY INFORMATION: Title: Credit Account Approval for Reimbursable... Inspection Service [Docket No. APHIS-2010-0071] Notice of Request for Extension of Approval of an Information...

  19. 78 FR 54617 - Notice of Request for Extension of Approval of an Information Collection; Credit Account Approval...

    Science.gov (United States)

    2013-09-05

    ...] Notice of Request for Extension of Approval of an Information Collection; Credit Account Approval for... (202) 799-7039 before coming. FOR FURTHER INFORMATION CONTACT: For information on credit account... Coordinator, at (301) 851-2908. SUPPLEMENTARY INFORMATION: Title: Credit Account Approval for Reimbursable...

  20. Why Bringing Back Grammar Schools Is Not Proving a Popular Idea: Two Successes for the Comprehensive Argument in Recent Student Union Debates

    Science.gov (United States)

    Benn, Melissa

    2015-01-01

    As moves grow once more to expand selective education in the United Kingdom, this is a short report of two lively and well-attended debates at the universities of Manchester and Cambridge in the early part of 2015. Both debates were resoundingly won by those arguing against a return to a divisive system based on the 11+. Instead, audiences…

  1. Building Successful Information Systems – a Key for Successful Organization

    Directory of Open Access Journals (Sweden)

    Doina ROSCA

    2010-12-01

    Full Text Available Building Successful Information Systems – a Key for Successful OrganizationAbstract: An Information System (IS can have a major impact on corporate strategy and organizational success. The involvement of managers and decision makers in all aspects of information systems is a major factor for organizational success, including higher profits and lower costs. Some of the benefits business organization seek to achieve through information systems include: better safety, competitive advantage, fewer errors, greater accuracy, higher quality products, improved communications, increased efficiency and productivity, more efficient administration, superior financial and managerial decision making.

  2. Rose George: Deep Sea and Foreign Going: Inside Shipping, the Invisible Industry that Brings you 90% of Everything

    DEFF Research Database (Denmark)

    Taudal Poulsen, René

    2014-01-01

    Book review of: Rose George: Deep Sea and Foreign Going: Inside Shipping, the Invisible Industry that Brings you 90% of Everything. London :Portobello Books, 2013. 320 pp. ISBN 9781846272639......Book review of: Rose George: Deep Sea and Foreign Going: Inside Shipping, the Invisible Industry that Brings you 90% of Everything. London :Portobello Books, 2013. 320 pp. ISBN 9781846272639...

  3. 36 CFR 1280.8 - May I bring a seeing-eye dog or other assistance animal?

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false May I bring a seeing-eye dog or other assistance animal? 1280.8 Section 1280.8 Parks, Forests, and Public Property NATIONAL... dog or other assistance animal? Yes, persons with disabilities may bring guide dogs or other animals...

  4. Governance as an instrument of successful organizational integration.

    Science.gov (United States)

    Lozon, Jeffrey C; Vernon, Sarah E

    2002-01-01

    In July 1997 the Health Services Restructuring Commission (HSRC) issued a formal direction to the Wellesley Central Hospital to relinquish the operation and management of its programs and services to St. Michael's Hospital. This event propelled staff and volunteers into four years of unrelenting efforts to bring together the mission, vision, values, human resources, clinical programs and broad communities of these two very unique and long-standing organizations. Looking back, the result was arguably one of the most successful hospital mergers in the province at that time. A number of factors were responsible for this outcome. The tremendous value of a strong and integrated governance team clearly stands out as one of the most pivotal success factors. This article examines the principles and structures that guided the governance team and St. Michael's Hospital to a stronger and more vibrant future.

  5. Emotional Intelligence and its Relation to Job Success

    Directory of Open Access Journals (Sweden)

    MA. Dua Dauti-Kadriu

    2015-12-01

    Full Text Available Until three decades ago the importance of Emotional Intelligence, now on referred as EI, was not very well known. Existing as a concept EI was not unanimously defined, not in its merited place in science and not well known in society opinion. The concept of EI for the first time arose in 1990 by Peter Salovey and John Mayer. It evolved later and achieved its peak with the work of Daniel Goldman in 1995, where his book on EI named: “EI, why it Matters” sold millions of copies. Nowadays after many researches done in EI field, EI with its main components has been rightly acknowledged as an engine of a human body toward achieving one’s self-satisfaction and success. However this still has not happened in Kosova. This is one of the first articles written in Kosova about EI, the new concept of Intelligence. The paper will try to give the contribution on the field of bringing EI in its merited place in Kosova society, and so will positively affect the investment of individuals into their EI, being one of the main factors that bring you towards success and overall wellbeing.

  6. Trial endpoints for drug approval in oncology: Chemoprevention.

    Science.gov (United States)

    Beitz, J

    2001-04-01

    As with other drugs, new drug applications for marketing approval of chemopreventive drugs must include data from adequate and well-controlled clinical trials that demonstrate effectiveness and safety for the intended use. This article summarizes the regulatory requirements for traditional marketing approval, as well as for approval under the accelerated approval regulations. Unlike traditional approval, accelerated approval is based on a surrogate endpoint that is reasonably likely to predict clinical benefit. Discussions with the Food and Drug Administration (FDA) regarding the validity of trial endpoints that may serve as surrogates for clinical benefit for accelerated approval should take place as early as possible in drug development. Meetings with the FDA to discuss these issues may be requested throughout the clinical development of a new drug.

  7. International partnerships : a road map to success

    International Nuclear Information System (INIS)

    Hall, B.

    2006-01-01

    Green Breeze was founded in 2003, and was initially a small wind farm development company with 5 employees before creating partnerships with both local and North American companies in order to expand. The company now has 50 employees that work within 3 separate divisions, namely Green Breeze Energy Systems (GBES); Green Breeze Wind Park Development (GBWPD); and Compsotech. This presentation described the company's business strategy. GBES was created to meet market demand for small wind turbines. Barriers to success included the fact that market demand outweighed Canadian supply, and that Canadian suppliers were still challenged by technical issues. In order to maintain Canadian content and meet the needs of their clients, GBES formed a partnership with the Danish company WES to bring 80 kW and 250 kW turbines into Ontario. By partnering with WES, the company has been able to create a stable supply chain for customers while maintaining ties to Canadian turbine suppliers. GBWPD was created to develop utility-scale wind generation. The company did not win a contract in any recent requests for proposals (RFPs), which led them to conclude that smaller developers seemed to be excluded from the electricity market. As the aim of the organization was to develop projects and not simply model them, they have chosen to focus on smaller wind projects outside the RFP process. However, smaller projects have had limited access to financing and turbine suppliers. In order to address these issues GBWPD formed a partnership with ENERCON which provided financial support as well as access to German foundation specialists and the E48 turbine. Seven of the turbines are now planned for installation in 2007. The partnership has allowed GBWPD to bring over 150 MW of projects into their portfolio. In early 2006, Green Breeze bought controlling interest in Composotech Structures, a company specializing in structural composites manufacturing as well as turbine blade manufacturing and repair

  8. The Healthy ALLiances (HALL) framework: prerequisites for success.

    Science.gov (United States)

    Koelen, Maria A; Vaandrager, Lenneke; Wagemakers, Annemarie

    2012-04-01

    Chronic conditions are on the rise worldwide, and there is increasingly a call for the primary care and public health sectors to join forces in alliances. GPs have an important role to play in such alliances. However, successful cooperation is not as obvious as it may seem, and the sectors are not used to working together. The objective is to identify conditions and prerequisites for successful alliances. Identification of conditions and prerequisites is mainly based on stepwise analysis and iterative developments in research on collaboration processes in the area of health promotion and public health. The process as a whole resulted in the framework presented in this paper. This so-called HALL framework identifies three clusters of factors that either hinder or facilitate the success of alliances: (i) institutional factors, (ii) personal factors of participants in the alliance and (iii) factors relating to the organization of the alliance. The institutional and personal factors 'stick' to the stakeholders and are brought into the alliance. The third group refers to the lessons learned from dealing with the first two characteristics to make the alliance successful. Partners in alliances bring in personal attributes and institutional characteristics that can form obstacles to successful alliances, but, when they are addressed in a flexible and positive way, obstacles can be turned in contributory factors, leading to many potential benefits, such as collaborative learning and innovation.

  9. OUT Success Stories: Rural Electrification in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Strawn, N.

    2000-08-31

    The United States and Brazil are collaborating to bring electricity to some 5 million households in rural Brazil. Over the next decade, there is a potential to install approximately 500 megawatts (MW) of solar home systems and 1000 MW of community systems, bringing light to households, schools, and health clinics throughout rural Brazil.

  10. Spent-fuel transportation - a success story

    International Nuclear Information System (INIS)

    Gertz, C.P.; Schoonen, D.H.; Wakeman, B.H.

    1986-01-01

    Spent nuclear fuel research and development (R and D) demonstrations and associated transportation activities are being performed as a part of the storage cask performance testing programs at the Idaho National Engineering Laboratory (INEL). These spent-fuel programs support the Nuclear Waste Policy Act (NWPA) and US Department of Energy (DOE) objectives for cooperative demonstrations with the utilities, testing at federal sites, and alternatives for viable transportation systems. A cooperative demonstration program with the private sector to develop dry storage technologies that the US Nuclear Regulatory Commission (NRC) can generically approve is in place as well as cost-shared dry storage R and D program at a federal facility to collect the necessary licensing data. In addition to the accomplishments in the cask performance and testing demonstrations, the long-distance transportation of a large number of spent-fuel assemblies is considered a success story. The evaluation and implementation of applicable requirements, industry perspective, and extensive planning all contributed to this achievement

  11. Act No. 160 of 17 March 1979 containing regulations approving the Paris Convention of 29 July 1960 on Third Party Liability in the Field of Nuclear Energy and its Additional Protocol of 28 January 1964 as well as the Brussels Convention of 31 January 1963 supplementary to the Paris Convention and its Additional Protocol of 28 January 1964

    International Nuclear Information System (INIS)

    1979-01-01

    By this Act the Netherlands approved the 1960 Paris Convention on Third Party Liability in the Field of Nuclear Energy, as well as the Brussels Convention of 1963 Supplementary to that Convention. This Act came into force on 28 December 1979 thus bringing into force on that date the Paris Convention and the Brussels Supplementary Convention in the Netherlands. (NEA) [fr

  12. Tracing the origins of success: implications for successful aging.

    Science.gov (United States)

    Peterson, Nora M; Martin, Peter

    2015-02-01

    This paper addresses the debate about the use of the term "successful aging" from a humanistic, rather than behavioral, perspective. It attempts to uncover what success, a term frequently associated with aging, is: how can it be defined and when did it first come into use? In this paper, we draw from a number of humanistic perspectives, including the historical and linguistic, in order to explore the evolution of the term "success." We believe that words and concepts have deep implications for how concepts (such as aging) are culturally and historically perceived. We take a comparative approach, turning to the etymological roots of this term in British, French, and German literature. According to the earliest entries of the term in the Oxford English Dictionary, events can have good or bad success. Another definition marks success as outcome oriented. Often used in the context of war, religion, and medicine, the neutral, but often negative, use of "success" in literature of the Renaissance demonstrates the tensions that surround the word, and suggests that success is something to be approached carefully. Ignoring the ambiguous origins of success erases the fact that aging in earlier centuries echoes much of the same ambivalence with which many people discuss it today. Attending to the origins of success can help gerontologists understand the humanistic tradition behind their inquiry into what successful aging means today. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  13. Innovating by developing new uses of already-approved drugs: trends in the marketing approval of supplemental indications.

    Science.gov (United States)

    DiMasi, Joseph A

    2013-06-01

    Much of the literature on trends and factors affecting biopharmaceutical innovation has focused overwhelmingly on the development and approval of never-before approved drugs and biologics. Little attention has been paid to new uses for already-approved compounds, which can be an important form of innovation. This paper aimed to determine and analyze recent trends in the number and type of new or modified US indication approvals for drugs and biologics. We also examine regulatory approval-phase times for new-use efficacy supplements and compare them to approval-phase times for original-use approvals over the same period. We developed a data set of efficacy supplements approved by the US Food and Drug Administration (FDA) from 1998 to 2011 that includes information on the type, approval-phase time (time from submission to the FDA of an application for marketing approval to approval of the application), and FDA therapeutic-significance rating for the approved application, which we obtained from an FDA Web site. This data set was merged with a Tufts Center for the Study of Drug Development (CSDD) data set of US new drug and biologics approvals. We developed descriptive statistics on trends in the number and type of new-use efficacy supplements, on US regulatory approval-phase times for the supplements, and on original new drug and biologics approvals over the study period and for the time from original- to new-use approval. The total number of new-use efficacy-supplement approvals did not exhibit a marked trend, but the number of new pediatric-indication approvals increased substantially. Approval-phase times for new-use supplements varied by therapeutic class and FDA therapeutic-significance rating. Mean approval-phase times were highest for central nervous system compounds (13.8 months) and lowest for antineoplastics (8.9 months). The mean time from original to supplement approval was substantially longer for new pediatric indications than for other new uses. Mean

  14. Scientific, economic, regulatory, and ethical challenges of bringing science-based pediatric nutrition products to the U.S. market and ensuring their availability for patients.

    Science.gov (United States)

    Merritt, Russell J; Goldsmith, Arthur H

    2014-11-01

    Many nutrition products and related drugs are unavailable or not consistently available to clinicians despite a body of clinical data and experience supporting their use. Many of these can be related to drug shortages that have increased since 2009. In addition, there are potentially useful products that are not approved for a specific use or are no longer being manufactured. This review broadly examines the product availability gap from the perspectives of a clinician/former nutrition industry medical director and an economist. The process of pediatric nutrition product and related drug innovation, as well as its drivers and the steps involved in bringing a product to market, is first described. This is followed by an assessment of factors influencing product availability beyond the innovation process, including regulatory issues, manufacturing compliance, purchasing practices, and other factors related to drug and nutrition product pricing and reimbursement. Three pediatric case examples are reviewed and placed in the context of the prior review. Last, recent and future possible steps toward closing the product availability gap are discussed. © 2014 American Society for Parenteral and Enteral Nutrition.

  15. Virtual Reality: Bringing the Awe of Our Science into The Classroom with VR

    Science.gov (United States)

    Bell, R. E.; Turrin, M.; Frearson, N.; Boghosian, A.; Ferrini, V. L.; Simpson, F.

    2016-12-01

    The geosciences are rich in imagery, making them compelling material for immersive teaching experiences. We often work in remote locations, places where few others are able to travel. Flat 2 D images from the field have served explorers and scientists well from the lantern slides brought back from Antarctica to the images scientists and educators now use in powerpoint presentations. These images provide a backdrop to introduce the experience for formal classes and informal presentations. Our stories from the field bring the setting alive for the participants. The travelers presented and the audience passively listened. Immersive learning opportunities are much more powerful than lecturing. We have enlisted both VR and drone imagery to bring learners fully into the experience of science. A 360 VR image brings the viewer into the moment of discovery. Both have been shown to create an active learning setting fully under the learner's control; they explore at their own pace and following their own interest. This learning `sticks', becoming part of the participant's own unique experience in the space. We are building VR images of field experiences and VR data immersion experiences that will transport people into new locations, building a field experience that they can not only see but fully explore. Through VR we introduce new experiences that showcase our science, our careers and our collaborations. Users can spin the view up to see the helicopter landing in a remote field location by the ice. Spin to the right and see a colleague collecting a reading from instruments that have been pulled from the LC130 aircraft. Turn the view to the left and see the harsh windswept environment along the edge of an ice shelf. Look down and note that you feet are encased in snow boots to keep them warm and stable on the ice. The viewer is in the field as part of the science team. Learning in the classroom and through social media is now fully 360 and fully immersive.

  16. The ‘added value’ GPs bring to commissioning: a qualitative study in primary care

    Science.gov (United States)

    Perkins, Neil; Coleman, Anna; Wright, Michael; Gadsby, Erica; McDermott, Imelda; Petsoulas, Christina; Checkland, Kath

    2014-01-01

    Background The 2012 Health and Social Care Act in England replaced primary care trusts with clinical commissioning groups (CCGs) as the main purchasing organisations. These new organisations are GP-led, and it was claimed that this increased clinical input would significantly improve commissioning practice. Aim To explore some of the key assumptions underpinning CCGs, and to examine the claim that GPs bring ‘added value’ to commissioning. Design and setting In-depth interviews with clinicians and managers across seven CCGs in England between April and September 2013. Method A total of 40 clinicians and managers were interviewed. Interviews focused on the perceived ‘added value’ that GPs bring to commissioning. Results Claims to GP ‘added value’ centred on their intimate knowledge of their patients. It was argued that this detailed and concrete knowledge improves service design and that a close working relationship between GPs and managers strengthens the ability of managers to negotiate. However, responders also expressed concerns about the large workload that they face and about the difficulty in engaging with the wider body of GPs. Conclusion GPs have been involved in commissioning in many ways since fundholding in the 1990s, and claims such as these are not new. The key question is whether these new organisations better support and enable the effective use of this knowledge. Furthermore, emphasis on experiential knowledge brings with it concerns about representativeness and the extent to which other voices are heard. Finally, the implicit privileging of GPs’ personal knowledge ahead of systematic public health intelligence also requires exploration. PMID:25348997

  17. Building an Undergraduate Book Approval Plan for a Large Academic Library

    Directory of Open Access Journals (Sweden)

    Denise Koufogiannakis

    2007-05-01

    Full Text Available The University of Alberta Libraries (UAL, working with two book vendors, created large-scale undergraduate book approval plans to deliver new publications. Detailed selections profiles were created for many subject areas, designed to deliver books that would have been obvious choices by subject selectors. More than 5800 monographs were received through the book approval plans during the pilot period. These volumes proved to be highly relevant to users, showing twice as much circulation as other monographs acquired during the same time period. Goals achieved through this project include: release of selectors’ time from routine work, systematic acquisition of a broadly based high-demand undergraduate collection and faster delivery of undergraduate materials. This successful program will be expanded and incorporated into UAL’s normal acquisitions processes for undergraduate materials.

  18. Test and Approval Center for Fuel Cell and Hydrogen Technologies: Phase I. Initiation

    DEFF Research Database (Denmark)

    already spent on these technologies also lead to commercial success. The project ‘Test and Approval Center for Fuel Cell and Hydrogen Technologies: Phase I. Initiation’ was aiming at starting with the Establishment of such a center. The following report documents the achievements within the project...... of the fluctuating wind energy. As the fuel cell and hydrogen technologies come closer to commercialization, development of testing methodology, qualified testing and demonstration become increasingly important. Danish industrial players have expressed a strong need for support in the process to push fuel cell...... and hydrogen technologies from the research and development stage into the commercial domain. A Center to support industry with test, development, analysis, approval, certification, consultation, and training in the areas of fuel cell and hydrogen technologies was needed. Denmark has demonstrated leading...

  19. Succession Planning for Library Instruction

    Science.gov (United States)

    Sobel, Karen; Drewry, Josiah

    2015-01-01

    Detailed succession planning helps libraries pass information from one employee to the next. This is crucial in preparing for hiring, turnover, retirements, training of graduate teaching assistants in academic libraries, and other common situations. The authors of this article discuss succession planning for instruction programs in academic…

  20. Success and Women's Career Adjustment.

    Science.gov (United States)

    Russell, Joyce E. A.; Burgess, Jennifer R. D.

    1998-01-01

    Women still face barriers to career success and satisfaction: stereotypes, assumptions, organizational culture, human resource practices, and lack of opportunities. Despite individual and organizational strategies, many women leave to become entrepreneurs. There is a need to investigate how women define career success. (SK)

  1. Does Happiness Promote Career Success?

    Science.gov (United States)

    Boehm, Julia K.; Lyubomirsky, Sonja

    2008-01-01

    Past research has demonstrated a relationship between happiness and workplace success. For example, compared with their less happy peers, happy people earn more money, display superior performance, and perform more helpful acts. Researchers have often assumed that an employee is happy and satisfied because he or she is successful. In this article,…

  2. Bringing science to bear--on peace, not war: elaborating on psychology's potential to promote peace.

    Science.gov (United States)

    Leidner, Bernhard; Tropp, Linda R; Lickel, Brian

    2013-10-01

    We argue that psychological and contextual factors play important roles in bringing about, facilitating, and escalating violent conflict. Yet rather than conclude that violent conflict is inevitable, we believe psychology's contributions can extend beyond understanding the origins and nature of violent conflict, to promote nonviolence and peace. In this article, we summarize psychological perspectives on the conditions and motivations underlying violent conflict. Drawing on this work, we then discuss psychological and contextual factors that can mitigate violence and war and promote nonviolence and peace. PsycINFO Database Record (c) 2013 APA, all rights reserved

  3. Old Books Bring New Life to the Brick and Mortar Library

    Science.gov (United States)

    Bosken, S.

    2012-08-01

    If all the library books and journals can be viewed on your desk top, why come to the physical library? The USNO Library tried to bring the patrons inside the library. One method was to rotate rare book displays each month. As the library holds a fabulous collection of ancient astronomy books, including Copernicus, Kepler, Galileo, and Newton, we have abundant resources. The presentation will highlight the varied displays and offer a Rare Books 101 explanation of paper, printing, binding and a behind-the-scenes look at how old books are maintained and preserved.

  4. The Robobo Project: Bringing Educational Robotics Closer to Real-World Applications

    DEFF Research Database (Denmark)

    Bellas, Francisco; Naya, Martin; Varela, Gervasio

    2017-01-01

    The Robobo Project is a STEM-based project that aims to bring educational robotics, in primary and high school, closer to real-world applications. It is based on the use of a smartphone-based robotic platform called Robobo, a very flexible programming environment, and a set of lessons to integrate...... them. The smartphone provides high-level hardware capabilities in terms of sensors, communications and processing capabilities that allow to create more practical and realistic lessons that exploit human-robot interaction, with a small investment. In this paper, we present the main elements...

  5. Perspectives on mathematical practices bringing together philosophy of mathematics, sociology of mathematics, and mathematics education

    CERN Document Server

    van Kerkhove, Bart

    2007-01-01

    Philosophy of mathematics today has transformed into a very complex network of diverse ideas, viewpoints, and theories. Sometimes the emphasis is on the ""classical"" foundational work (often connected with the use of formal logical methods), sometimes on the sociological dimension of the mathematical research community and the ""products"" it produces, then again on the education of future mathematicians and the problem of how knowledge is or should be transmitted from one generation to the next. The editors of this book felt the urge, first of all, to bring together the widest variety of aut

  6. Strategies of bringing drug product marketing applications to meet current regulatory standards.

    Science.gov (United States)

    Wu, Yan; Freed, Anita; Lavrich, David; Raghavachari, Ramesh; Huynh-Ba, Kim; Shah, Ketan; Alasandro, Mark

    2015-08-01

    In the past decade, many guidance documents have been issued through collaboration of global organizations and regulatory authorities. Most of these are applicable to new products, but there is a risk that currently marketed products will not meet the new compliance standards during audits and inspections while companies continue to make changes through the product life cycle for continuous improvement or market demands. This discussion presents different strategies to bringing drug product marketing applications to meet current and emerging standards. It also discusses stability and method designs to meet process validation and global development efforts.

  7. WERC -- a case study of a successful technology transfer partnership

    International Nuclear Information System (INIS)

    Bhada, R.K.; Ghassemi, A.; Jacquez, R.; Kauffman, D.

    1994-01-01

    In 1990, the Department of Energy approved a cooperative agreement for a Waste-management Education and Research Consortium (WERC) program. This consortium includes as its members the New Mexico State University (NMSU), the University of New Mexico (UNM), the New Mexico Institute of Mining and Technology (NMIMT), the Navajo Community College, the Los Alamos National Laboratory, and the Sandia National Laboratories working with industrial affiliates. Several of the unique technologies developed via WERC are successfully demonstrated /via application at national laboratories and industrial sites. Some examples are: Remediation of soil contaminated with plutonium using a polymer capture process has been applied at a DOE waste site; Subsurface mapping of buried waste has been applied at a DOE integrated demonstration (ID) site; and A pipeline detection system has been applied to leak detection from storage tanks and pipelines in the oil industry. This paper will present how the WERC partnership has been successful because of its unique structure and method of operation

  8. 75 FR 50711 - Approval and Promulgation of Air Quality Implementation Plans; Ohio; Final Approval and...

    Science.gov (United States)

    2010-08-17

    ... operations under OAC 3745-21-09(U)(2)(f). For administrative convenience, in a separate rulemaking published... conditional approval of portions of OAC rule 3745-21-09. You can learn more information about the rule... implementing a Federal Standard. National Technology Transfer Advancement Act In reviewing state submissions...

  9. 75 FR 54215 - Agency Request for Approval of a Previously Approved Information Collection(s): Uniform...

    Science.gov (United States)

    2010-09-03

    ... about our intention to request Office of Management and Budget (OMB) approval to renew a previously... because of management and oversight responsibilities of the agency imposed by OMB Circular 2 CFR 215 (A... Department has terminated Financial Status Report (SF-269 and SF-269A) and Federal Cash Transactions Report...

  10. 78 FR 63937 - Approval and Promulgation of Implementation Plans; Approval and Promulgation of State Air Quality...

    Science.gov (United States)

    2013-10-25

    ... Quality Plans for Designated Facilities and Pollutants, State of Iowa; Control of Emissions From Existing Hospital/ Medical/Infectious Waste Incinerator Units, Negative Declaration and 111(d) Plan Rescission... existing state air quality rules, approve an exemption from constructing permitting for engines used in...

  11. 78 FR 63887 - Approval and Promulgation of Implementation Plans; Approval and Promulgation of State Air Quality...

    Science.gov (United States)

    2013-10-25

    ... Quality Plans for Designated Facilities and Pollutants, State of Iowa; Control of Emissions From Existing Hospital/ Medical/Infectious Waste Incinerator Units, Negative Declaration and 111(d) Plan Rescission... quality rules, approve an exemption from constructing permitting for engines used in periodic pipeline...

  12. 77 FR 26474 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Approval of 2011 Consent...

    Science.gov (United States)

    2012-05-04

    ... Department of the Environment (MDE). These revisions approve specific provisions of a 2011 Consent Decree between MDE and GenOn to reduce particulate matter (PM), sulfur oxides (SO X ), and nitrogen oxides (NO X....regulations.gov or email. The www.regulations.gov Web site is an ``anonymous access'' system, which means EPA...

  13. 77 FR 26438 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Approval of 2011 Consent...

    Science.gov (United States)

    2012-05-04

    ... (MDE) pertaining to the GenOn Chalk Point Generating Station (Chalk Point). These revisions approve specific provisions of a 2011 Consent Decree between MDE and GenOn to reduce particulate matter (PM... www.regulations.gov or email. The www.regulations.gov Web site is an ``anonymous access'' system...

  14. 77 FR 59335 - Approval and Promulgation of Implementation Plans; North Carolina: Approval of Rocky Mount Motor...

    Science.gov (United States)

    2012-09-27

    ... account for any future changes to the emission model, projection model and other input data. \\2\\ A safety... changes in the emissions model and vehicle miles traveled (VMT) projection model. EPA is approving this... Regional Office's official hours of business are Monday through Friday, 8:30 to 4:30, excluding federal...

  15. Criteria for approving equipment for continued operation

    International Nuclear Information System (INIS)

    Narayanan, T.V.

    1993-01-01

    In May 1988, the Pressure Vessel Research Committee (PVRC) of the Welding Research Council (WRC) initiated four projects in support of ASME's efforts to develop Codes and Standards for life prediction and life extension of nuclear and fossil power plant components. These projects are: (1) Criteria for Approving Equipment for Continued Operation (2) Guidelines and Procedures for Evaluating Piping for Continued Operation (3) Nondestructive Evaluation of Material Degradation (4) Operation and Maintenance History and Life Cycle Management. The PVRC awarded a contract to Foster Wheeler Development Corporation to undertake the first of these projects. The specific objective was to develop a program plan that will lead to development of ''Criteria for Approving Equipment for Continued Operation.'' The program is divided into the following four tasks: Task 1: Literature Search; Task 2: Telephone Interview and Consultation; Task 3: Program Plan Development; Task 4: Preparation of a Summary Report. This report is in fulfillment of the above project. As part of this study, the author reviewed about 145 reports, papers and books relating to various aspects of life extension. Various experts were also consulted who are involved in EPRI, NRC, ASME, PVRC, MPC, and utility studies as well as other research projects. The conclusions and recommendations for Code-related activities are summarized

  16. Cancer nanomedicine: a review of recent success in drug delivery.

    Science.gov (United States)

    Tran, Stephanie; DeGiovanni, Peter-Joseph; Piel, Brandon; Rai, Prakash

    2017-12-11

    Cancer continues to be one of the most difficult global healthcare problems. Although there is a large library of drugs that can be used in cancer treatment, the problem is selectively killing all the cancer cells while reducing collateral toxicity to healthy cells. There are several biological barriers to effective drug delivery in cancer such as renal, hepatic, or immune clearance. Nanoparticles loaded with drugs can be designed to overcome these biological barriers to improve efficacy while reducing morbidity. Nanomedicine has ushered in a new era for drug delivery by improving the therapeutic indices of the active pharmaceutical ingredients engineered within nanoparticles. First generation nanomedicines have received widespread clinical approval over the past two decades, from Doxil ® (liposomal doxorubicin) in 1995 to Onivyde ® (liposomal irinotecan) in 2015. This review highlights the biological barriers to effective drug delivery in cancer, emphasizing the need for nanoparticles for improving therapeutic outcomes. A summary of different nanoparticles used for drug delivery applications in cancer are presented. The review summarizes recent successes in cancer nanomedicine in the clinic. The clinical trials of Onivyde leading to its approval in 2015 by the Food and Drug Adminstration are highlighted as a case study in the recent clinical success of nanomedicine against cancer. Next generation nanomedicines need to be better targeted to specifically destroy cancerous tissue, but face several obstacles in their clinical development, including identification of appropriate biomarkers to target, scale-up of synthesis, and reproducible characterization. These hurdles need to be overcome through multidisciplinary collaborations across academia, pharmaceutical industry, and regulatory agencies in order to achieve the goal of eradicating cancer. This review discusses the current use of clinically approved nanomedicines, the investigation of nanomedicines in clinical

  17. SUCCESSION MANAGEMENT: UPAYA HUMAN RESOURCE PLANNING MENUJU SUCCESS CORPORATE

    Directory of Open Access Journals (Sweden)

    Rini Kuswati

    2010-06-01

    create a more flexible and dynamic approach for preparing future executive and have the leadership necessary ready to meet the business challenges of the remainder of the decade and beyond. Succession management allows the corporate leadership to instill a more dynamic process became easier to integrate with the firm’s strategic initiatives. It better aligns organizational thinking with the external environment where the discontinuities make it possible to anticipate the full spectrum of change that a corporation will confront. It is the leadership and succession philosophy that focuses on developing the creativity and flexibility that allows for a more rapid response to change. So succession management as one way to became the success corporate.

  18. Applying for ethical approval for research: the main issues.

    Science.gov (United States)

    Gelling, Leslie

    2016-01-13

    The need to obtain research ethical approval is common to all research involving human participants. This approval must be obtained before research participants can be approached and before data collection can begin. The process of ethical review is one way that research participants can be confident that possible risks have been considered, minimised and deemed acceptable. This article outlines some of the main issues researchers should consider when planning an application for research ethical approval by answering the following six questions: 'Do I need research ethical approval?', 'How many applications will I need to make?', 'Where should I apply for research ethical approval?', 'What do I need to include in my application?', 'What do research ethics committees look for?' and 'What other approvals might I need?' Answering these questions will enable researchers to navigate the ethical review process.

  19. The Commonwealth Games as an Example of Bringing States Closer Through Sport

    Directory of Open Access Journals (Sweden)

    Kobierecki Michał Marcin

    2017-03-01

    Full Text Available The aim of the article is to investigate the issue of positive sports diplomacy directed at bringing countries closer and deepening cooperation between them. Generally, sports diplomacy is a broader term and may include various ways of utilizing sport, both negative and positive, even for the sake of nation-branding. Positive sports diplomacy most commonly refers to bringing hostile states closer together, but it may also be used to deepen political alliances or foster friendship and cooperation between states that are not mutually hostile. The research focuses on the latter form of positive sports diplomacy. The investigation is a case study concerning the Commonwealth Games, a sports event that is held once every four years and gathers countries and territories that used to belong to the former British Empire. The research therefore aims to determine whether this event, the second largest multisport event in the world, is significant from political and diplomatic perspectives. A second research question concerns whether the Commonwealth Games should be seen as an attempt by Great Britain to maintain influence in its former colonies. The research attempts to test the hypothesis that the Commonwealth Games are an important contributor to sustaining ties between states of the former British Empire.

  20. Where has the public gone and will communications technology bring them back?

    International Nuclear Information System (INIS)

    Hutterman, L.; Smith, R.

    1997-01-01

    This paper addresses the decreasing number of persons interested and participating in the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) or open-quotes Superfundclose quotes process. It also looks at communications technology to bring people back into participation in the Superfund process. The material studied and the technologies evaluated involve the Environmental Restoration Program at the Idaho National Engineering and Environmental Laboratory. The conclusions are probably valid for most DOE Superfund activities. Where has the public gone? The public has taken an interest in issues that they perceive have greater impact on their quality of life and that have an adverse impact on the environment, such as the shipment and storage of spent nuclear fuel. Will communications technology bring them back? Technology can do many things: it can reduce cost; it can allow quicker access to and from the public; it can offer more information; and it can increase interest because of its novelty for short periods of time, but it will not, in and of its own, create public involvement