Sample records for subjects developed ad

  1. Adding Needed Development. (United States)

    Jones, Juanita; And Others

    This handbook, written in a conversational tone, is to help the teacher of very young children work effectively with the child who evidences a high risk for a learning disability. Based upon the theories of child development of Gesell, Piaget, and Kephart, this manual attempts to provide prescriptive activities for specific learning problems in…

  2. Adding a subjective dimension to an ICF-based disability measure for people with multiple sclerosis : development and use of a measure for perception of disabilities

    NARCIS (Netherlands)

    Wynia, K.; Middel, B.; de Ruiter, H.; van Dijk, J.P.; Lok, W.S.; De Keyser, J.H.; Reijneveld, S.A.


    Objective. The subjective dimension of disability, the perception of disability, is a dimension missing from the International Classification of Functioning, Disability and Health (ICF), and from health-related quality of life (HRQOL) instruments. However, it is a highly relevant dimension for

  3. Accelerator development in India for ADS programme

    Indian Academy of Sciences (India)

    Abstract. At BARC, development of a Low Energy High Intensity Proton Accelerator. (LEHIPA), as front-end injector of the 1 GeV accelerator for the ADS programme, has been initiated. The major components of LEHIPA (20 MeV, 30 mA) are a 50 keV ECR ion source, a 3 MeV Radio Frequency Quadrupole (RFQ) and a 20 ...

  4. Accelerator development in India for ADS programme

    Indian Academy of Sciences (India)

    LEHIPA), as front-end injector of the 1 GeV accelerator for the ADS programme, has been initiated. The major components of LEHIPA (20 MeV, 30 mA) are a 50 keV ECR ion source, a 3 MeV Radio Frequency Quadrupole (RFQ) and a 20 MeV drift ...

  5. Recognition of activities of daily living in healthy subjects using two ad-hoc classifiers. (United States)

    Urwyler, Prabitha; Rampa, Luca; Stucki, Reto; Büchler, Marcel; Müri, René; Mosimann, Urs P; Nef, Tobias


    Activities of daily living (ADL) are important for quality of life. They are indicators of cognitive health status and their assessment is a measure of independence in everyday living. ADL are difficult to reliably assess using questionnaires due to self-reporting biases. Various sensor-based (wearable, in-home, intrusive) systems have been proposed to successfully recognize and quantify ADL without relying on self-reporting. New classifiers required to classify sensor data are on the rise. We propose two ad-hoc classifiers that are based only on non-intrusive sensor data. A wireless sensor system with ten sensor boxes was installed in the home of ten healthy subjects to collect ambient data over a duration of 20 consecutive days. A handheld protocol device and a paper logbook were also provided to the subjects. Eight ADL were selected for recognition. We developed two ad-hoc ADL classifiers, namely the rule based forward chaining inference engine (RBI) classifier and the circadian activity rhythm (CAR) classifier. The RBI classifier finds facts in data and matches them against the rules. The CAR classifier works within a framework to automatically rate routine activities to detect regular repeating patterns of behavior. For comparison, two state-of-the-art [Naïves Bayes (NB), Random Forest (RF)] classifiers have also been used. All classifiers were validated with the collected data sets for classification and recognition of the eight specific ADL. Out of a total of 1,373 ADL, the RBI classifier correctly determined 1,264, while missing 109 and the CAR determined 1,305 while missing 68 ADL. The RBI and CAR classifier recognized activities with an average sensitivity of 91.27 and 94.36%, respectively, outperforming both RF and NB. The performance of the classifiers varied significantly and shows that the classifier plays an important role in ADL recognition. Both RBI and CAR classifier performed better than existing state-of-the-art (NB, RF) on all ADL. Of the two

  6. Developing a value-added Web site. (United States)

    Turisco, F; Kilbridge, P M


    Once a healthcare organization has decided to establish a Web site on the Internet, it must next determine its implementation strategy, based on a full understanding of the goals of the site and the range of Web content and service offerings available in the marketplace. Although some organizations may choose to develop and maintain a Web site using exclusively in-house resources, most healthcare organizations will find that they can minimize the costs associated with this effort by making judicious use of outsourcing services. Whichever approach is used, it is important that financial managers charged with allocating resources for Web-site development and maintenance understand the implications, including relative financial impact, of key issues and options.

  7. Adjustment on subjective annoyance of low frequency noise by adding additional sound (United States)

    Di, Guo-qing; Li, Zheng-guang; Zhang, Bang-jun; Shi, Yao


    Structure-borne noise originating from a heat pump unit was selected to study the influence on subjective annoyance of low frequency noise (LFN) combined with additional sound. Paired comparison test was used for evaluating the subjective annoyance of LFN combined with different sound pressure levels (SPL) of pink noise, frequency-modulated pure tones (FM pure tones) and natural sounds. The results showed that, with pink noise of 250-1000 Hz combined with the original LFN, the subjective annoyance value (SAV) first dropped then rose with increasing SPL. When SPL of the pink noise was 15-25 dB, SAV was lower than that of the original LFN. With pink noise of frequency 250-20,000 Hz added to LFN, SAV increased linearly with increasing SPL. SAV and the psychoacoustic annoyance value (PAV) obtained by semi-theoretical formulas were well correlated. The determination coefficient ( R2) was 0.966 and 0.881, respectively, when the frequency range of the pink noise was 250-1000 and 250-20,000 Hz. When FM pure tones with central frequencies of 500, 2000 and 8000 Hz, or natural sounds (including the sound of singing birds, flowing water, wind or ticking clock) were, respectively, added to the original sound, the SAV increased as the SPL of the added sound increased. However, when a FM pure tone of 15 dB with a central frequency of 2000 Hz and a modulation frequency of 10 Hz was added, the SAV was lower than that of the original LFN. With SPL and central frequency held invariable, the SAV declined primarily when modulation frequency increased. With SPL and modulation frequency held invariable, the SAV became lowest when the central frequency was 2000 Hz. This showed a preferable correlation between SAV and fluctuation extent of FM pure tones.

  8. Subjective truths: participatory development assessment

    NARCIS (Netherlands)

    Dietz, T.; Obeng, F.; Obure, J.; Zaal, F.


    The starting point for development evaluations should be how the recipients of development assistance experience change, rather than the set perspectives of the evaluators. The participatory development assessment (PDA) methodology is designed to involve recipients in evaluations.

  9. Subject to Form: Research Interviews, Performative Subjectivity, Professional Development (United States)

    Sarigianides, Sophia Tatiana


    In this dissertation, I analyze teacher, literacy coach and researcher subjectivities in a five-year study of on-site professional development with middle-grade Language Arts teachers in a school designated by its district and state as severely underperforming. Interested in the role of research interviews as both research method and cultural…

  10. Recent Developments of Protein Kinase Inhibitors as Potential AD Therapeutics

    Directory of Open Access Journals (Sweden)

    Andreas eHilgeroth


    Full Text Available Present AD therapies suffer from inefficient effects on AD symptoms like memory or cognition, especially in later states of the disease. Used acteylcholine esterase (ACE inhibitors or the NMDA receptor antagonist memantine address one target structure which is involved in a complex, multifactorial disease progression. So the benefit for patients is presently poor. A more close insight in the AD progression identified more suggested target structures for drug development. Strategies of AD drug development concentrate on novel target structures combined with the established ones dedicated for combined therapy regimes, preferably by the use of one drug which may address two target structures. Protein kinases have been identified as promising target structures because they are involved in AD progression pathways like pathophysiological tau protein phosphorylations and amyloid β toxicity. The review article will shortly view early inhibitors of single protein kinases like glycogen synthase kinase (gsk3 β and cyclin dependent kinase 5. Novel inhibitors will be discussed which address novel AD relevant protein kinases like dual-specifity tyrosine phosphorylation regulated kinase 1A (DYRK1A. Moreover, multitargeting inhibitors will be presented which target several protein kinases and those which are suspected in influencing other AD relevant processes. Such a multitargeting is the most promising strategy to effectively hamper the multifactorial disease progression and thus gives perspective hopes for a future better patient benefit.

  11. Development of value added tea bags and capsules of Artemisia ...

    African Journals Online (AJOL)

    Propagation to budding/harvesting took 4 months and fresh leaves were processed to dark green dried leaves which was developed to value added products of tea bags and powdered capsules following the Noble Icon NAFDAC approved procedures and equipment; and Now Food University in USA procedures and ...

  12. Local Development of Subject Area Item Banks. (United States)

    Ward, Annie W.; Barlow, Gene


    It is feasible for school districts to develop and use subject area tests as reliable as those previously available only from commercial publishers. Three projects in local item development in a large school district are described. The first involved only Algebra 1. The second involved life science and career education at the elementary level; and…

  13. Adding Value to Customers and Developing Brands through Electronic Newsletters

    Directory of Open Access Journals (Sweden)

    Alexandra ZBUCHEA


    Full Text Available Online communication is highly efficient for contemporary business, in most market sectors. In this context, companies use several online instruments in order to achieve a wide array of objectives. Among these, online newsletters (e-newsletters are widely used, since they offer a lot of benefits for companies. Since they are flexible in terms of format and content, they are suitable to address a wide variety of publics. Therefore, e-newsletters could be not just informative (as they are widely seen, but also could add-value to customers and support branding processes and relationship development. The present paper investigated various benefits of e-newsletters in this context and highlights some rules to ensure an effective added-value e-newsletter. The research made on the e-newsletters of 5 of the leading publishing-houses in Romania shows that, at least in this market sector, this instrument is not used at its full potential. It is considered in most cases a way to stimulate sales, either directly by announcing sales, or indirectly by announcing new books releases. In some cases news on events and on the activity of the publishing-houses are presenting, leading to image development.

  14. Development, test-retest reliability and validity of the Pharmacy Value-Added Services Questionnaire (PVASQ

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    Tan CL


    Full Text Available Objective: (i To develop the Pharmacy Value-Added Services Questionnaire (PVASQ using emerging themes generated from interviews. (ii To establish reliability and validity of questionnaire instrument. Methods: Using an extended Theory of Planned Behavior as the theoretical model, face-to-face interviews generated salient beliefs of pharmacy value-added services. The PVASQ was constructed initially in English incorporating important themes and later translated into the Malay language with forward and backward translation. Intention (INT to adopt pharmacy value-added services is predicted by attitudes (ATT, subjective norms (SN, perceived behavioral control (PBC, knowledge and expectations. Using a 7-point Likert-type scale and a dichotomous scale, test-retest reliability (N=25 was assessed by administrating the questionnaire instrument twice at an interval of one week apart. Internal consistency was measured by Cronbach’s alpha and construct validity between two administrations was assessed using the kappa statistic and the intraclass correlation coefficient (ICC. Confirmatory Factor Analysis, CFA (N=410 was conducted to assess construct validity of the PVASQ. Results: The kappa coefficients indicate a moderate to almost perfect strength of agreement between test and retest. The ICC for all scales tested for intra-rater (test-retest reliability was good. The overall Cronbach’ s alpha (N=25 is 0.912 and 0.908 for the two time points. The result of CFA (N=410 showed most items loaded strongly and correctly into corresponding factors. Only one item was eliminated. Conclusions: This study is the first to develop and establish the reliability and validity of the Pharmacy Value-Added Services Questionnaire instrument using the Theory of Planned Behavior as the theoretical model. The translated Malay language version of PVASQ is reliable and valid to predict Malaysian patients’ intention to adopt pharmacy value-added services to collect partial

  15. Recent development in wireless sensor and ad-hoc networks

    CERN Document Server

    Li, Xiaolong; Yang, Yeon-Mo


    Wireless Sensor Network (WSN) consists of numerous physically distributed autonomous devices used for sensing and monitoring the physical and/or environmental conditions. A WSN uses a gateway that provides wireless connectivity to the wired world as well as distributed networks. There are many open problems related to Ad-Hoc networks and its applications. Looking at the expansion of the cellular infrastructure, Ad-Hoc network may be acting as the basis of the 4th generation wireless technology with the new paradigm of ‘anytime, anywhere communications’. To realize this, the real challenge would be the security, authorization and management issues of the large scale WSNs. This book is an edited volume in the broad area of WSNs. The book covers various chapters like Multi-Channel Wireless Sensor Networks, its Coverage, Connectivity as well as Deployment. It covers comparison of various communication protocols and algorithms such as MANNET, ODMRP and ADMR Protocols for Ad hoc Multicasting, Location Based C...

  16. How Stable Are Value-Added Estimates across Years, Subjects and Student Groups? What We Know Series: Value-Added Methods and Applications. Knowledge Brief 3 (United States)

    Loeb, Susanna; Candelaria, Christopher A.


    Value-added models measure teacher performance by the test score gains of their students, adjusted for a variety of factors such as the performance of students when they enter the class. The measures are based on desired student outcomes such as math and reading scores, but they have a number of potential drawbacks. One of them is the…

  17. History of modern optics ad optoelectronics development in China

    CERN Document Server

    Tian, Shouyun


    This book presents a collection of memoir papers on the development of modern and contemporary optics and optoelectronics in China from the 18th to 20th centuries. The papers were written by famous scientists in China, including members of the Chinese Academy of Sciences and the Chinese Academy of Engineering, sharing their experience in different fields of optics and optoelectronics development. This is a unique book in understanding the natural science history of optics and optoelectronics. It gives you the general idea about how the western optical science spread to China in the 17th to 18th century; the cradle of the contemporary optics in China; Birth, development and application of lasers in China; high energy and high power lasers for laser antiballistic missile and laser nuclear fusion; development of Chinese optical communication and optical information storage; laser and infrared optics research for space science; development of Chinese optical instruments, etc.

  18. Adding to Product Development Theory - A Language Perspective

    DEFF Research Database (Denmark)

    Hansen, Poul H. Kyvsgård; Berg, Pekka; Mabogunje, Ade


    The paper explores the effect that the languages associated with the applied methods have on product development processes. Product development does increasingly involve more diverse disciplines and expanded cross-disciplinary views. Most importantly, the new disciplines: Design Thinking, and......, Innovation Management have introduced new cross-disciplinary methods and approaches. Some of the most important cognitive processes involved in product development: perceiving, meaning making, conceptualizing, communicating, and learning have been reframed and expanded as new disciplines have been introduced...... of these new languages reveals that the traditional methods applied in product development are highly influenced and limited by the languages that are traditionally associated with the application of these methods. Though language plays an important part in these essential processes it is rarely addressed...

  19. Institutions of Religious Education ad their Historical Development in Indonesia


    Göksoy, İsmail Hakkı


    This paper mainly deals with the religious educational institutions and their historical developments in Indonesia. It firstly focuses on the state of general education during the Dutch colonial and the Republican periods. Afterwards, it begins with the investigation of traditional religious educational system. In this respect, the historical development and the structure of religious educational establishments of pesantrens and the aspects. of educational life in these religious schools are ...


    African Journals Online (AJOL)

    Ifedotun Aina

    Artemisia Annua Anamed (A-3) cultivar seeds were obtained from REAP in Kenya and propagated in Ilorin, Nigeria; ... afford costly pharmaceutical ACT in the growing and development of the dried A-3 leaves as herb tea for ..... of Moringa Products for Nutraceutical Benefits in Ilorin, Kwara State, Nigeria. Agrosearch 13.

  1. Subjective dimension in the analysis of human development

    Directory of Open Access Journals (Sweden)

    LÓPEZ NOVAL, Borja


    Full Text Available In recent years subjective evaluations about own quality of life, resumed in levels of life satisfactionor happiness, are gaining importance as indicators of development. Some authors state that subjectivewell-being is a necessary and sufficient condition for human development. In this work the arguments ofthese authors are explained and it is discussed the role subjective evaluations must play on developmentstudies. The main conclusion is that although it is necessary to integrate subjective well-being into humandevelopment studies we cannot identify subjective well-being and development.

  2. Subjectivity

    Directory of Open Access Journals (Sweden)

    Jesús Vega Encabo


    Full Text Available In this paper, I claim that subjectivity is a way of being that is constituted through a set of practices in which the self is subject to the dangers of fictionalizing and plotting her life and self-image. I examine some ways of becoming subject through narratives and through theatrical performance before others. Through these practices, a real and active subjectivity is revealed, capable of self-knowledge and self-transformation. 

  3. Developing a biomedical expert finding system using medical subject headings. (United States)

    Singh, Harpreet; Singh, Reema; Malhotra, Arjun; Kaur, Manjit


    Efficient identification of subject experts or expert communities is vital for the growth of any organization. Most of the available expert finding systems are based on self-nomination, which can be biased, and are unable to rank experts. Thus, the objective of this work was to develop a robust and unbiased expert finding system which can quantitatively measure expertise. Medical Subject Headings (MeSH) is a controlled vocabulary developed by the National Library of Medicine (NLM) for indexing research publications, articles and books. Using the MeSH terms associated with peer-reviewed articles published from India and indexed in PubMed, we developed a Web-based program which can be used to identify subject experts and subjects associated with an expert. We have extensively tested our system to identify experts from India in various subjects. The system provides a ranked list of experts where known experts rank at the top of the list. The system is general; since it uses information available with the PubMed, it can be implemented for any country. The expert finding system is able to successfully identify subject experts in India. Our system is unique because it allows the quantification of subject expertise, thus enabling the ranking of experts. Our system is based on peer-reviewed information. Use of MeSH terms as subjects has standardized the subject terminology. The system matches requirements of an ideal expert finding system.

  4. Subjective age in the academic development of Algerian students

    Directory of Open Access Journals (Sweden)



    Full Text Available Subjective age has been studied in various domains (health, consumption, work, but the works which investigated the subjective age that the students give themselves during their academic development are rare (Pavalache & Rioux, 2014. One-hundred-and-twenty-two Algerian students answered a questionnaire comprising (a an identification part (b the subjective age questionnaire by Gana, Alaphilippe and Bailly, (2002 and (c the questionnaire of subjective age in academic development (Pavalache & Rioux, 2014. The results show that the Algerian students have a tendency to rejuvenate themselves, all the more so if they are of male gender. They show the impact of the societal and cultural factors on subjective age in academic development of university students.

  5. The development trend of adjusted value added in selected transport companies in the Czech Republic


    Šenec, Alexandr; Pazderková, Ivana


    The article deals with the development of the value added per employee in a public transport. The value added is adjusted by the reimbursement for demonstrable loss from state, region or municipality that guarantee transport services on the particular areas. The economy of transport companies combines the basic business target - a profit - and the possibility of the financial support from state, region or municipality in a form of a reimbursement for demonstrable loss. The article analyzes th...

  6. Psychopathological symptoms, defense mechanisms and time perspectives among subjects with alcohol dependence (AD) presenting different patterns of coping with stress. (United States)

    Iwanicka, Katarzyna; Gerhant, Aneta; Olajossy, Marcin


    The problem of coping with stress is an important one in the context of development and persistence of alcohol dependence. In the literature to date very little attention has been paid to coping patterns construed as a configuration of specific coping styles, particularly as regards the functioning of addicted individuals. The aim of the study was to verify whether individuals with alcohol dependence characterized by different coping patterns differ with respect to the severity of psychopathological symptoms, defense mechanisms and time perspectives. Participants were given a battery of psychological tests-Coping Inventory for Stresfull Situations (CISS), Defense Style Questionnaire (DSQ 40), Syndrom Checklist (SCL-90) and Short Zimbardo Time Perspective Inventory (SZPTI-PL). The sample comprised 112 individuals with alcohol dependence, aged 20 to 63 years old, the average age was 37.86; 78 percent were men. There were identified three sub-groups of individuals characterized by a distinctive patterns of coping with stress -"emotional-avoidant", "task oriented" and a "mixed one". Individuals with the predominant emotional-avoidant coping pattern are characterized by significantly higher severity of psychopathological symptoms, less mature defense mechanisms and past time perspectives. Subjects reliant on task-oriented coping pattern were characterized by the highest level of adaptation and the most constructive way of functioning in the face of difficulties. It is worth regarding the examination of patterns of coping as an indispensable element of collecting medical history from alcohol dependent individuals.

  7. Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: an MRI study of 676 AD, MCI, and normal subjects. (United States)

    Hua, Xue; Leow, Alex D; Parikshak, Neelroop; Lee, Suh; Chiang, Ming-Chang; Toga, Arthur W; Jack, Clifford R; Weiner, Michael W; Thompson, Paul M


    In one of the largest brain MRI studies to date, we used tensor-based morphometry (TBM) to create 3D maps of structural atrophy in 676 subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and healthy elderly controls, scanned as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI). Using inverse-consistent 3D non-linear elastic image registration, we warped 676 individual brain MRI volumes to a population mean geometric template. Jacobian determinant maps were created, revealing the 3D profile of local volumetric expansion and compression. We compared the anatomical distribution of atrophy in 165 AD patients (age: 75.6+/-7.6 years), 330 MCI subjects (74.8+/-7.5), and 181 controls (75.9+/-5.1). Brain atrophy in selected regions-of-interest was correlated with clinical measurements--the sum-of-boxes clinical dementia rating (CDR-SB), mini-mental state examination (MMSE), and the logical memory test scores - at voxel level followed by correction for multiple comparisons. Baseline temporal lobe atrophy correlated with current cognitive performance, future cognitive decline, and conversion from MCI to AD over the following year; it predicted future decline even in healthy subjects. Over half of the AD and MCI subjects carried the ApoE4 (apolipoprotein E4) gene, which increases risk for AD; they showed greater hippocampal and temporal lobe deficits than non-carriers. ApoE2 gene carriers--1/6 of the normal group--showed reduced ventricular expansion, suggesting a protective effect. As an automated image analysis technique, TBM reveals 3D correlations between neuroimaging markers, genes, and future clinical changes, and is highly efficient for large-scale MRI studies.

  8. Potential of Compost with Some Added Supplementary Materials on the Development of Agaricus blazei Murill


    Horm, Visal; Ohga, Shoji; 大賀, 祥治


    Potential of compost on the development of Agaricus blazei Murill was evaluated on various compost concentrations with two kinds of supplementary materials. Sugarcane compost as well as cattle compost added with sawdust and rice bran was influential substrates on mycelial growth and fruit body development. The fast spawn running was realized on cattle compost concentrations, but primordial formation and fruit body development took a short period on sugarcane compost concentrations. All cattle...

  9. Influence of adding nanoparticles on the hardness, tear strength, and permanent deformation of facial silicone subjected to accelerated aging. (United States)

    Nobrega, Adhara S; Andreotti, Agda M; Moreno, Amália; Sinhoreti, Mário A C; Dos Santos, Daniela M; Goiato, Marcelo C


    The efficiency of adding nanoparticles to silicone protection has proven to prevent color degradation. However, reports of other physical property changes in facial silicone are scarce. The purpose of this in vitro study was to evaluate the influence of adding nanoparticles on the hardness, tear strength, and permanent deformation of a facial silicone. Specimens were made for each test, with 140 for the hardness test, 140 for the permanent deformation test, but 280 for the rupture test. This higher number was due to the fact that the first 140 specimens were ruptured and unusable after the initial reading. ZnO, BaSO 4 , and TiO 2 nanoparticles at concentrations of 1% and 2% of silicone were used, as well as specimens without nanoparticles that consisted of only oil paint and of only silicone. Outcomes were measured before and after 1008 hours of accelerated aging. Data were analyzed by nested analysis of variance (ANOVA) and Tukey honest significant differences test (α=.05). Results showed that the presence of nanoparticles influenced the properties of the assessed groups. The nanoparticles decreased hardness values. The highest values of tear strength were observed for the groups with addition of BaSO 4 . The 1% ZnO group without oil paint showed the lowest values of permanent deformation. Based on the findings of this in vitro study, the use of ZnO nanoparticles is recommended, since they did not negatively affect the properties of the materials evaluated. Copyright © 2016 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

  10. Development Of Dynamic Probabilistic Safety Assessment: The Accident Dynamic Simulator (ADS) Tool

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Y.H.; Mosleh, A.; Dang, V.N


    The development of a dynamic methodology for Probabilistic Safety Assessment (PSA) addresses the complex interactions between the behaviour of technical systems and personnel response in the evolution of accident scenarios. This paper introduces the discrete dynamic event tree, a framework for dynamic PSA, and its implementation in the Accident Dynamic Simulator (ADS) tool. Dynamic event tree tools generate and quantify accident scenarios through coupled simulation models of the plant physical processes, its automatic systems, the equipment reliability, and the human response. The current research on the framework, the ADS tool, and on Human Reliability Analysis issues within dynamic PSA, is discussed. (author)

  11. What spouse caregivers know about communication in Alzheimer's disease: development of the AD Communication Knowledge Test. (United States)

    Williams, Christine L


    Most individuals with Alzheimer's disease are cared for at home by family members, particularly spouses. As language impairment progresses, communication between spouses becomes difficult and caregivers are likely to be unprepared for this challenge. The purpose of this study is to describe spouse caregivers' knowledge of communication in AD and to determine their learning needs regarding effective communication strategies. A measure of knowledge about declining language skills and appropriate communication strategies was developed and pilot tested. Participants included 16 spouses caring for a partner with AD at home. Care recipients were generally mildly impaired. Caregivers were aware of at least some of the decline in language but were less knowledgeable about communication strategies. They were experiencing numerous communication problems, but reported minimal difficulty in communicating. Nurses in acute and long-term care settings are challenged to assess spouses' knowledge and awareness about communication in AD and provide information about effective communication strategies to decrease misunderstandings and frustration, which often lead to behavior problems. Recommendations for further development of the AD Communication Knowledge Test are offered.

  12. The Diagnostic Method Features of Communication Subject Development (ORSO

    Directory of Open Access Journals (Sweden)

    Lioznova E.V.,


    Full Text Available The purpose of the article is familiarization with the development of questionnaire "Features of communication subject development" (ORSO. This new psychodiagnostic tool assesses communicative personality traits, its characteristics as the subject of communication. We present the theoretical foundation of the approach to the personality as a subject of communication, propose a structure of such subject, including two levels of properties: generic and specific. The latter include the responsibility in communication, unconditional acceptance of self, attitude to the partner as an absolute value. The questionnaire comprises five scales and measures the level of these features, as well as integrated communication success rate. The accuracy of responses is controlled by the scale of the adequacy of self-esteem. We describe communication styles, revealed by the ratio of the generic properties. The test is intended for men and women older than 12 years and allows to predict the success of communication with different partners in different situations and features of communicative behavior, attitudes, experiences of the respondent. We presented satisfactory performance criteria of test quality: reliability, validity and representativeness of the ORSO technique, provide examples of its application in scientific and applied purposes and prospects for future work.

  13. Development, chemical and sensory characterization of semi skim yogurt added with whey protein concentrate

    Directory of Open Access Journals (Sweden)

    Andressa Regina Antunes


    Full Text Available The aim of this work was to develop, to perform the chemical characterization and verify the acceptability of a semi skim yogurt added with whey protein concentrate (WPC 35 %, and compare it to traditional yogurt, without adding any protein source. For this, two formulations were prepared: 1- traditional semi skim and 2: semi skim added with WPC 35 %, with subsequent evaluation of physicochemical characteristics of acidity, pH and viscosity, as well as the compositional analysis of the levels of humidity, full solids, ash, protein, fat and carbohydrates for both formulations. The sensory analysis was performed with 80 untrained tasters, which was based on parameters of appearance, taste, flavor and consistency. The appearance and consistency parameters showed a significant difference between received grades, and the yogurt added with WPC 35 % the most preferred these aspects, as well as the formulation with the highest widespread acceptance among testers. The results indicate that the use of WPC 35 % in foods is a promising alternative, considering the overall acceptance obtained, the protein content beneficial to the consumers health, the improvement of technological properties provided to food coupled to the extent which it is produced, low cost and reducing the damage caused to the environment. 

  14. Developing the Immunology Book for Animal and Human Physiology Subject

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    Zuni Mitasari


    Full Text Available he objective of the study was to develop an immunology book for Animal and Human Physiology subject. This book was developed based on the Thiagarajan development model which was modified of: Define, Design, Develop, dan Disseminate (4D. The data expert validation instrument was questionnaire using Likert scales, comments, and recommendation sheets. Expert appraisal was done by material expert and media and design learning expert. The developmental testing was conducted using questionnaire to test the readibility. The expert validation was conducted by material expert as well as design and media learning expert validator; meanwhile, the field test was done to measure the readability. The validity test results were: the material expert state that the material is valid (97.14%, as well as the design and learning media expert (84.88% and field test by students (88.17%.


    Directory of Open Access Journals (Sweden)

    Retno Subekti


    Full Text Available This article was written to share the experiences of teaching 'trading or doing business' in the subject of Ilmu Hitung Keuangan in 2010. This Article also share about the phenomenon of appeared ‘kantin kejujuran’ or the honesty canteen in Mathematics and Natural Sciences Faculty of Yogyakarta State University in early 2011. Based on the syllabus of the subject, there is a topic of trading that makes lecturer is motivated to participate in developing the entrepreneurial spirit of students. The way taken by the lecturer was giving big trust to the students to manage funds for trading. Before trading begins, students should discuss about what are the things that can be bought cheaply and then sold with ease so that will give them the advantage. The result is that all groups got benefit. 4 groups formed are the group of ‘donuts’, ‘accessories’, ‘snacks’, and ‘stickers’. Then groups of food division that are donuts group and snack’s one were part of the pioneers of honesty canteen. This method is in line with lecturers expectancy to participate and develop entrepreneurship on campus.

  16. Application of gas-cooled Accelerator Driven System (ADS) transmutation devices to sustainable nuclear energy development

    Energy Technology Data Exchange (ETDEWEB)

    Abanades, A., E-mail: [ETSII/Universidad Politecnica de Madrid, J.Gutierrez Abascal, 2-28006 Madrid (Spain); Garcia, C.; Garcia, L. [Instituto Superior de Tecnologia y Ciencias Aplicadas. Quinta de los, Molinos, Ave. Salvador Allende y Luaces, Ciudad de la Habana, CP 10400, Apartado Postal 6163 (Cuba); Escriva, A.; Perez-Navarro, A. [Instituto de Ingenieria Energetica, Universidad Politecnica de Valencia, C.P. 46022 Valencia (Spain); Rosales, J. [Instituto Superior de Tecnologia y Ciencias Aplicadas. Quinta de los, Molinos, Ave. Salvador Allende y Luaces, Ciudad de la Habana, CP 10400, Apartado Postal 6163 (Cuba)


    Highlights: > Utilization of Accelerator Driven System (ADS) for Hydrogen production. > Evaluation of the potential use of gas-cooled ADS for a sustainable use of Uranium resources by transmutation of nuclear wastes, electricity and Hydrogen production. > Application of the Sulfur-Iodine thermochemical process to subcritical systems. > Application of CINDER90 to calculate burn-up in subcritical systems. - Abstract: The conceptual design of a pebble bed gas-cooled transmutation device is shown with the aim to evaluate its potential for its deployment in the context of the sustainable nuclear energy development, which considers high temperature reactors for their operation in cogeneration mode, producing electricity, heat and Hydrogen. As differential characteristics our device operates in subcritical mode, driven by a neutron source activated by an accelerator that adds clear safety advantages and fuel flexibility opening the possibility to reduce the nuclear stockpile producing energy from actual LWR irradiated fuel with an efficiency of 45-46%, either in the form of Hydrogen, electricity, or both.

  17. Solutions without Space-Time Separation for ADS Experiments: Overview on Developments and Applications

    Directory of Open Access Journals (Sweden)

    B. Merk


    Full Text Available The different analytical solutions without space-time separation foreseen for the analysis of ADS experiments are described. The SC3A experiment in the YALINA-Booster facility is described and investigated. For this investigation the very special configuration of YALINA-Booster is analyzed based on HELIOS calculations. The results for the time dependent diffusion and the time dependent P1 equation are compared with the experimental results for the SC3A configuration. A comparison is given for the deviation between the analytical solution and the experimental results versus the different transport approximations. To improve the representation to the special configuration of YALINA- Booster, a new analytical solution for two energy groups with two sources (central external and boundary source has been developed starting form the Green's function solution. Very good agreement has been found for these improved analytical solutions.

  18. Development of an AD/RANS model for predicting wind turbine wakes

    DEFF Research Database (Denmark)

    Tian, Linlin; Zhu, Wei Jun; Shen, Wen Zhong


    methods together. The simulations are performed by using the in-house flow solver EllipSys3D coupled with the actuator disc (AD) methodology. The main objective of the proposed model is to control the turbulence decay caused by the intrinsic property of the two-equation turbu-lence model and further...... increasing the pre-dicted turbulence intensity through correct-ing the destruction terms. To validate the proposed method, comparisons are carried out between measurements and other nu-merical simulations for the Nibe B wind tur-bine. Results show that the newly developed model can provide satisfactory...... predictions for the wind speed deficit and the turbulence intensity....

  19. Development and Pre-Clinical Evaluation of a Novel Prostate-Restricted Replication Competent Adenovirus-Ad-IU-1

    National Research Council Canada - National Science Library

    Gardner, Thomas A


    .... The goal of this research is to develop a novel therapeutic agent, Ad-IU-1, using PSES to control the replication of adenovirus and the expression of a therapeutic gene, herpes simplex thymidine kinase (TK...

  20. Development and Pre-Clinical Evaluation of a Novel Prostate-Restricted Replication Competent Adenovirus-AD-IU-1

    National Research Council Canada - National Science Library

    Gardner, Thomas A


    ... independent prostate cancers. The goal of this research is to develop a novel therapeutic agent, Ad-IU-1, using PSES to control the replication of adenovirus and the expression of a therapeutic gene, herpes simplex thymidine kinase (TK...

  1. Development and Pre-Clinical Evaluation of a Novel Prostate-Restricted Replication Competent Adenovirus-AD-IU-1

    National Research Council Canada - National Science Library

    Gardner, Thomas


    ... independent prostate cancers. The goal of this research is to develop a novel therapeutic agent, Ad-lu-1, using PSES to control the replication of adenovirus and the expression of a therapeutic gene, herpes simplex thymidine kinase...

  2. Troll oil. Added value and technological development; Troll olje. Verdiskapning og teknologiutvikling

    Energy Technology Data Exchange (ETDEWEB)



    The story about oil extraction from the Troll petroleum reservoirs in the Troll petroleum project, is the story about a very large petroleum reservoir, but very difficult to access. A project that despite vast, technological challenges created a foundation for one of the genuine pioneer projects on Norwegian continental shelf. The social impact of Troll Oil is substantial. The project has generated big, economic profits, strengthened Norwegian and international contractor companies, and contributed to important technological improvements in both drilling- and completion technology, as well as sub sea production. Many of the technological solutions that have been developed in relation to the Troll Oil project have been further developed and used in new fields both in Norway and in other countries. Troll Oil is an excellent example that much of the added value on Norwegian shelf is inextricably connected to technology and competency developments. The project has become a very important point of reference for Norwegian petroleum industry in international markets, and has been an essential factor in the efforts to demonstrate the possibilities of enhanced oil recovery. The success for Troll Oil has contributed to the authorities - and the oil companies - constantly setting higher extraction goals.

  3. Measuring Subjective Happiness by Newly Developed Scale in Tehran, Iran

    Directory of Open Access Journals (Sweden)

    Kambiz Abachizadeh


    Full Text Available Background: Happiness as one of the main positive health indicators has drawn more attention in recent years among policy makers and health system managers. There are few studies performed to measure happiness in population-based settings in Iran. In response to this need, our study tends to assess Iranians subjective happiness in Tehran, Capital city of Iran.Materials and Methods: Present study was conducted in Tehran, Capital of Iran, with more than 7 Million populations in January 2013, using a two-step approach. In first step c conceptual framework of Iranians’ happiness was developed. In the second phase of study, a survey recruiting 700 participants was conducted. Stratified cluster sampling method was employed. Participants were recruited from all the 22 municipal divisions of Tehran as strata, proportional to the population size and its gender and age distribution. Happiness was measure by a 40-item questionnaire with scores ranged among 40 to 200.Results: Conceptual framework of Iranians’ happiness based on reviewed documents and consensus building process was the product of first step. At second step, from a pool of 700 persons, 696 (97% agreed to participate and filled out the questionnaire completely.  The mean of happiness score was 143.9 (95% confidence interval, 142.5 to 145.4. The results show that the happiness score of jobless people (135.1, 95%CI: 128.1-142.0 and widowed singles (126.6, 95%CI: 113.0-140.2 were significantly lower than other corresponding groups. There was no significant association between gender, age group, educational level as determinants and happiness.Conclusion: Happiness level of Tehranians is somewhat higher than the moderate level. This finding is consistent with findings of other conducted studies in country. However, it is not consistent with some of international reports of happiness, For instance, Happy Planet Index. Due to inadequate information, it is necessary to conduct more research to

  4. Further Development of Synchronous Array Method for Ad Hoc Wireless Networks

    Directory of Open Access Journals (Sweden)

    Yingbo Hua


    Full Text Available A further development of the synchronous array method (SAM as a medium access control scheme for large-scale ad hoc wireless networks is presented. Under SAM, all transmissions of data packets between adjacent nodes are synchronized on a frame-by-frame basis, and the spacing between concurrent cochannel transmissions of data packets is properly controlled. An opportunistic SAM (O-SAM is presented which allows concurrent cochannel transmissions to be locally adaptive to channel gain variations. A distributed SAM (D-SAM is discussed that schedules all concurrent cochannel transmissions in a distributed fashion. For networks of low mobility, the control overhead required by SAM can be made much smaller than the payload. By analysis and simulation, the intranetwork throughput of O-SAM and D-SAM is evaluated. The effects of traffic load and multiple antennas on the intranetwork throughput are studied. The throughput of ALOHA is also analyzed and compared with that of O-SAM and D-SAM. By a distance-weighted throughput, a comparison of long distance transmission versus short distance transmission is also presented. The study of D-SAM reveals an important insight into the MSH-DSCH protocol adopted in IEEE 802.16 standards.

  5. Development of functional canned and pouched tuna products added inulin for commercial production. (United States)

    Rueangwatcharin, U; Wichienchot, S


    Four formulas of canned tuna in spring water and tuna in mayonnaise and pouched tuna in salad cream and tuna in thousand island cream with added inulin were developed for commercial production. The effects of the addition of a prebiotic (inulin, Orafti®-HP) on the color and sensory properties of these products were studied. For inulin concentrations studied (3, 5, 7 and 10 %, w/w) caused more intensed yellow and red colors. Hedonic sensory values of tuna packed in spring water and in mayonnaise showed no significant differences (p > 0.05) among products with different inulin addition levels (3, 5, 7 and 10 %, w/w) in terms of color, flavor, sweetness and overall characteristics. However, when packed in thousand island cream, significant differences (p thousand island and tuna in salad cream, respectively. Considering formula cost in a commercial production and the recommended daily intake (RDI) of inulin in the finished product at end of shelf life (≥3 g/d), an addition of 5 % inulin for tuna in spring water and 7 % inulin for tuna in mayonnaise, tuna in thousand island and tuna in salad cream are recommended.

  6. Beyond human subjects: risk, ethics, and clinical development of nanomedicines. (United States)

    Kimmelman, Jonathan


    Clinical testing of nanomedicines presents two challenges to prevailing, human subject-centered frameworks governing research ethics. First, some nanomedical applications may present risk to persons other than research subjects. Second, pressures encountered in testing nanomedicines may present threats to the kinds of collaborations and collective activities needed for supporting clinical translation and redeeming research risk. In this article, I describe how similar challenges were encountered and addressed in gene transfer, and sketch policy options that might be explored in the nanomedicine translation arena. © 2012 American Society of Law, Medicine & Ethics, Inc.

  7. Educational Added Value Unit: Development and Testing of a Measure for Educational Activities. (United States)

    Guiot, Amy B; Kirkendall, Eric S; Gosdin, Craig H; Shah, Samir S; DeBlasio, Dominick J; Meier, Katie A; O'Toole, Jennifer K


    University-based hospitalists educate health care professionals as an expectation, often lacking time and support for these activities. The purpose of this study was to (1) develop a tracking tool to record educational activities, (2) demonstrate its applicability and ease of completion for faculty members in different divisions, and (3) compare educational efforts of individuals from different professional pathways and divisions by using the educational added value unit (EAVU). Educational activities were selected and ranked according to preparation effort, presentation time, and impact to calculate the EAVU. Faculty participants from 5 divisions at 1 institution (hospital medicine, general and community pediatrics, emergency medicine, behavior medicine and clinical psychology, and biostatistics and epidemiology) completed the retrospective, self-report tracking tool. A total of 62% (74 of 119) of invited faculty members participated. All faculty earned some EAVUs; however, there was a wide distribution range. The median EAVU varied by division (hospital medicine [21.7], general and community pediatrics [20.6], emergency medicine [26.1], behavior medicine and clinical psychology [18.3], and biostatistics and epidemiology [8.2]). Faculty on the educator pathway had a higher median EAVU compared with clinical or research pathways. The EAVU tracking tool holds promise as a mechanism to track educational activities of different faculty pathways. EAVU collection could be of particular benefit to hospitalists, who often perform unsupported teaching activities. Additional studies are needed to determine how to apply a similar process in different institutions and to determine how EAVUs could be used for additional support for teaching, curriculum development, and educational scholarship. Copyright © 2017 by the American Academy of Pediatrics.

  8. Added Sugar, Macro- and Micronutrient Intakes and Anthropometry of Children in a Developing World Context. (United States)

    Maunder, Eleni M W; Nel, Johanna H; Steyn, Nelia P; Kruger, H Salome; Labadarios, Demetre


    The objective of this study was to determine the relationship between added sugar and dietary diversity, micronutrient intakes and anthropometric status in a nationally representative study of children, 1-8.9 years of age in South Africa. Secondary analysis of a national survey of children (weighted n = 2,200; non weighted n = 2818) was undertaken. Validated 24-hour recalls of children were collected from mothers/caregivers and stratified into quartiles of percentage energy from added sugar (% EAS). A dietary diversity score (DDS) using 9 food groups, a food variety score (FVS) of individual food items, and a mean adequacy ratio (MAR) based on 11 micronutrients were calculated. The prevalence of stunting and overweight/obesity was also determined. Added sugar intake varied from 7.5-10.3% of energy intake for rural and urban areas, respectively. Mean added sugar intake ranged from 1.0% of energy intake in Quartile 1 (1-3 years) (Q1) to 19.3% in Q4 (4-8 years). Main sources of added sugar were white sugar (60.1%), cool drinks (squash type) (10.4%) and carbonated cool drinks (6.0%). Added sugar intake, correlated positively with most micronutrient intakes, DDS, FVS, and MAR. Significant negative partial correlations, adjusted for energy intake, were found between added sugar intake and intakes of protein, fibre, thiamin, pantothenic acid, biotin, vitamin E, calcium (1-3 years), phosphorus, iron (4-8 years), magnesium and zinc. The prevalence of overweight/obesity was higher in children aged 4-8 years in Q4 of %EAS than in other quartiles [mean (95%CI) % prevalence overweight 23.0 (16.2-29.8)% in Q4 compared to 13.0 (8.7-17.3)% in Q1, p = 0.0063]. Although DDS, FVS, MAR and micronutrient intakes were positively correlated with added sugar intakes, overall negative associations between micronutrients and added sugar intakes, adjusted for dietary energy, indicate micronutrient dilution. Overweight/obesity was increased with higher added sugar intakes in the 4-8 year old

  9. Added Sugar, Macro- and Micronutrient Intakes and Anthropometry of Children in a Developing World Context.

    Directory of Open Access Journals (Sweden)

    Eleni M W Maunder

    Full Text Available The objective of this study was to determine the relationship between added sugar and dietary diversity, micronutrient intakes and anthropometric status in a nationally representative study of children, 1-8.9 years of age in South Africa.Secondary analysis of a national survey of children (weighted n = 2,200; non weighted n = 2818 was undertaken. Validated 24-hour recalls of children were collected from mothers/caregivers and stratified into quartiles of percentage energy from added sugar (% EAS. A dietary diversity score (DDS using 9 food groups, a food variety score (FVS of individual food items, and a mean adequacy ratio (MAR based on 11 micronutrients were calculated. The prevalence of stunting and overweight/obesity was also determined.Added sugar intake varied from 7.5-10.3% of energy intake for rural and urban areas, respectively. Mean added sugar intake ranged from 1.0% of energy intake in Quartile 1 (1-3 years (Q1 to 19.3% in Q4 (4-8 years. Main sources of added sugar were white sugar (60.1%, cool drinks (squash type (10.4% and carbonated cool drinks (6.0%. Added sugar intake, correlated positively with most micronutrient intakes, DDS, FVS, and MAR. Significant negative partial correlations, adjusted for energy intake, were found between added sugar intake and intakes of protein, fibre, thiamin, pantothenic acid, biotin, vitamin E, calcium (1-3 years, phosphorus, iron (4-8 years, magnesium and zinc. The prevalence of overweight/obesity was higher in children aged 4-8 years in Q4 of %EAS than in other quartiles [mean (95%CI % prevalence overweight 23.0 (16.2-29.8% in Q4 compared to 13.0 (8.7-17.3% in Q1, p = 0.0063].Although DDS, FVS, MAR and micronutrient intakes were positively correlated with added sugar intakes, overall negative associations between micronutrients and added sugar intakes, adjusted for dietary energy, indicate micronutrient dilution. Overweight/obesity was increased with higher added sugar intakes in the 4-8 year old

  10. Subject Knowledge Development by Science Student Teachers: The Role of University Tutors and School-Based Subject Mentors (United States)

    Youens, Bernadette; McCarthy, Susan


    Following the introduction of a National Curriculum for Science, all secondary science teachers in England need to be prepared to teach all aspects of a broad and balanced science curriculum. This is the second paper in which we explore science student teachers' subject knowledge development during a one-year postgraduate teacher preparation…

  11. How Achieving the Millennium Development Goals Increases Subjective Well-Being in Developing Nations

    Directory of Open Access Journals (Sweden)

    Shizuki Fukuda


    Full Text Available The target date in 2015 for the United Nation’s Millennium Development Goals (MDGs was reached, and a new period of global goals for the post-2015 is dawning. To assess whether and how regional progress towards achieving the MDGs has contributed to better quality of life in developing nations, we formulated a correlation between various aspects of human development, indicated by MDG indicators, and subjective well-being (SWB, a response to the question of how much people feel happy or satisfied. We demonstrated that national levels of SWB can be explained by the degree of development; poverty reduction is the strongest determinant, and achieving the MDGs is associated with higher SWB levels. Scenario assessment of SWB allowed which domain of development should be improved preferentially in each region to be determined, hence the SWB approach is expected to offer an innovative proxy of human development for the assessment of the Sustainable Development Goals (SDGs.

  12. Energy Research and Development Administration Ad Hoc Computer Networking Group: experimental program

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, I.


    The Ad Hoc Computer Networking Group was established to investigate the potential advantages and costs of newer forms of remote resource sharing and computer networking. The areas of research and investigation that are within the scope of the ERDA CNG are described. (GHT)

  13. Accounting for Co-Teaching: A Guide for Policymakers and Developers of Value-Added Models (United States)

    Isenberg, Eric; Walsh, Elias


    We outline the options available to policymakers for addressing co-teaching in a value-added model. Building on earlier work, we propose an improvement to a method of accounting for co-teaching that treats co-teachers as teams, with each teacher receiving equal credit for co-taught students. Hock and Isenberg (2012) described a method known as the…

  14. E-Books in the Early Literacy Environment: Is There Added Value for Vocabulary Development? (United States)

    Roskos, Kathleen A.; Sullivan, Shannon; Simpson, Danielle; Zuzolo, Nicole


    Using a theory of affordances, this study examines the introduction of e-books into the early literacy environment as resources that can increase children's opportunity for learning vocabulary. Added value was observed under conditions of (1) book browsing, (2) instruction, and (3) a print-only condition. A total of 33 4-year-olds (18 boys, 15…

  15. Subject of research on effects of tourism on population development

    Directory of Open Access Journals (Sweden)

    Devedžić Mirjana


    Full Text Available The importance of tourism in the context of economic and demographic recovery of certain regions has created an image of tourism as a development catalyst. Thus strategies of revitalization in depopulated and passive regions often consider tourism as an activity that can speed up the development and successfully valorize existing natural, cultural and demographic potentials. This "key" is used mainly in the absence of other development resources since tourism valorizes issues that other industries ignore (landscape features, ethnical heritage, authentic folk architecture, etc. In addition it is more difficult to recommend the right forms of tourism to be developed in depopulated regions, as well as to estimate the resulting economic and demographic effects. To this end, there are success stories, but there is also evidence of non-rational initiatives and projects that were never completed. This paper attempts to discover the most logical links between population development and tourism development, based on some important characteristics of population development. The characteristics used are overall population increase, population migrations, population structures and changes in households. They were selected because they best reflect not only direct, but also indirect multiplicative effects of tourism. Along with the theoretical and methodological background, the research is also supported by selected examples, interviews, and demographic analyzes. The effects are not universal. They depend on the region, the kind of tourism and the degree of its development, the demographic situation as it is, and the research approach, since global and local effects need not necessarily be unidirectional. Population increase initiated by tourism development is achieved due to the migration component, but the effects are most obvious at the level of tourist regions and their tourist centers. One can also note counter processes in some places that have tourist

  16. An Evaluation of the Added Value of Co-Design in the Development of an Educational Game for Road Safety (United States)

    All, Anissa; Van Looy, Jan; Castellar, Elena Patricia Nuñez


    This study explores the added value of co-design in addition to other innovation research methods in the process of developing a serious game design document for a road safety game. The sessions aimed at exploring 4 aspects of a location-based game experience: themes, game mechanics, mobile phone applications and locations for mini-games. In…

  17. Scoring System Development and Added Value of Albuminuria to Estimate Carotid Intima-media Thickness (CIMT) in Type 2 Diabetes Mellitus Patients. (United States)

    Wijaya, Indra; Yunir, Em; Dharmeizar, Dharmeizar; Wijaya, Ika Prasetya; Setiati, Siti


    to develop a scoring system and measure the diagnostic added value of albuminuria to estimate CIMT. cross-sectional study was done in Endocrine Outpatient Clinic Cipto Mangunkusumo Hospital between March-May 2012 in T2DM patients without history of cerebrocardiovascular event, CKD stage ≥ III, and smoking. Bivariate analysis and multivariate (logistic regression) analysis was done, followed by developing the scoring system. from 71 subjects, there were 67.6% with increased CIMT and 73.3% with albuminuria. From 48 subjects with increased CIMT, 87.5% had albuminuria. Albuminuria measurement had high sensitivity (87.5%). Adding albuminuria measurement will increase the AUC as 2.3%. Estimation score for duration of DM, hypertension, dyslipidemia were as follows 1, 2, 1 respectively. Probability score of increased CIMT for score 2 was as follows 15%, 57%, and 90%. albuminuria measurement increase the diagnostic value of CIMT. Scoring system can be used as a screening tool to estimate the increased of CIMT in type 2 DM patients without history of cerebrocardiovascular event, CKD stage ≥ III, and smoking.

  18. Student feedback on a pioneer subject on leadership and intrapersonal development in Hong Kong. (United States)

    Shek, Daniel T L; Yu, Lu; Xie, Qiu Zhi


    To promote leadership and intrapersonal development in university students, a subject entitled "Tomorrow's Leaders" was developed and offered at The Hong Kong Polytechnic University. To assess the perceived effectiveness of this subject, 647 students completed the student feedback questionnaire (SFQ). Results showed that the feedback questionnaire had very good psychometric properties, including internal consistency reliability and construct validity. Regarding students' views of the subject, results showed that students generally had good evaluation of the content of the subject, teaching quality, and perceived benefits of the subject. The present findings have implications for the teaching of general education regarding leadership development.

  19. Comparison of the traditional paper visual analogue scale questionnaire with an Apple Newton electronic appetite rating system (EARS) in free living subjects feeding ad libitum. (United States)

    Stratton, R J; Stubbs, R J; Hughes, D; King, N; Blundell, J E; Elia, M


    Assessing the value of a newly developed electronic visual analogue scale questionnaire (Apple Newton Message Pad) with the traditional paper method for appetite rating. In a random, crossover design, subjects completed both electronic and paper questionnaires to compare results obtained by the two methods; individual methods were completed consecutively to assess test-retest reliability; preference was established using a questionnaire. Healthy, free-living adults were studied for comparison of methods (n = 12), test-retest reliability (n = 8) and preference (n = 13). Visual analogue scales were completed each waking hour to assess appetite. Preference was assessed after both methods were completed. There was no significant difference in the hourly results obtained by the paper and electronic methods for 'desire to eat', 'how much can you eat now', 'urge to eat' and 'preoccupation with thoughts of food'. Small differences in 'hunger' and 'fullness' ratings were noted (approximately 5% mean difference between methods, P Apple Newton questionnaire is as sensitive and reliable as the paper method, has the advantage that it automatically records the time of data acquisition and data collection and processing are more efficient for the researcher. The two methods should not be used interchangeably.

  20. Development of a method to manufacture uncured, no-nitrate/nitrite-added whole muscle jerky. (United States)

    Sindelar, Jeffrey J; Terns, Matthew J; Meyn, Elizabeth; Boles, Jane A


    "Natural curing" is accomplished by use of vegetable juice/powder high in naturally occurring nitrates combined with a nitrate reducing starter culture to result in indirectly "cured" products. Since the starter culture used is not water soluble, making "naturally cured" whole muscle jerky with current manufacturing techniques has been found ineffective. The objective was to investigate processes for whole muscle beef jerky that might provide cured meat characteristics similar to those of a nitrite-added control. Treatments where jerky was placed in a barrier bag during incubation were found to be the least similar to the nitrite-added control. Jerky placed in a 40.6 degrees C smokehouse during incubation resulted in significantly more (P<0.05) converted cured pigment than the barrier bag treatments but less (P<0.05) than the control. The processing methods investigated to manufacture "naturally cured" whole muscle jerky in this study were ineffective in resulting in products similar to those cured with sodium nitrite. Published by Elsevier Ltd.

  1. The Influence of a Mouthpiece-Based Topography Measurement Device on Electronic Cigarette User's Plasma Nicotine Concentration, Heart Rate, and Subjective Effects Under Directed and Ad Libitum Use Conditions. (United States)

    Spindle, Tory R; Hiler, Marzena M; Breland, Alison B; Karaoghlanian, Nareg V; Shihadeh, Alan L; Eissenberg, Thomas


    Electronic cigarettes e-cigarettes aerosolize a liquid solution often containing nicotine. e-cigarette nicotine delivery may be influenced by user puffing behaviors ("puff topography"). E-cigarette puff topography can be recorded using mouthpiece-based computerized systems. The present study sought to examine the extent to which these systems influence e-cigarette nicotine delivery and other e-cigarette associated acute effects under ad libitum use conditions. Plasma nicotine concentration, heart rate, and subjective effects were assessed in 29 experienced e-cigarette users using their preferred e-cigarette battery and liquid (≥12mg/mL nicotine) in two sessions differing only by the presence of a mouthpiece-based device. In both sessions, participants completed a directed e-cigarette use bout (10 puffs, 30-s interpuff interval) and a 90-min ad libitum bout. Puff topography was recorded in the session with the topography mouthpiece. Plasma nicotine, heart rate, and subjective effects, aside from "Did the e-cigarette Taste Good?" were independent of topography measurement (higher mean taste ratings were observed in the no topography condition). Mean (SEM) plasma nicotine concentration following the ad libitum bout was 34.3ng/mL (4.9) in the no topography condition and 35.7ng/mL (4.3) in the topography condition. Longer puff durations, longer interpuff intervals, and larger puff volumes were observed in the ad libitum relative to the directed bout. E-cigarette use significantly increased plasma nicotine concentration and heart rate while suppressing abstinence symptoms. These effects did not differ when a topography mouthpiece was present. Future studies using ad libitum e-cigarette use bouts would facilitate understanding of e-cigarette toxicant yield. No prior study has examined whether mouthpiece-based topography recording devices influence e-cigarette associated nicotine delivery, heart rate, or subjective effects under ad libitum conditions or assessed ad

  2. Geothermal drilling ad completion technology development program. Semi-annual progress report, April-September 1979

    Energy Technology Data Exchange (ETDEWEB)

    Varnado, S.G. (ed.)


    The progress, status, and results of ongoing Research and Development (R and D) within the Geothermal Drilling and Completion Technology Development Program are described. The program emphasizes the development of geothermal drilling hardware, drilling fluids, and completion technology. Advanced drilling systems are also under development. The goals of the program are to develop the technology required to reduce well costs by 25% by 1982 and by 50% by 1986.

  3. Hairy AdS solitons

    Energy Technology Data Exchange (ETDEWEB)

    Anabalón, Andrés, E-mail: [Departamento de Ciencias, Facultad de Artes Liberales and Facultad de Ingeniería y Ciencias, Universidad Adolfo Ibáñez, Av. Padre Hurtado 750, Viña del Mar (Chile); Astefanesei, Dumitru, E-mail: [Instituto de Física, Pontificia Universidad Católica de Valparaíso, Casilla 4059, Valparaíso (Chile); Choque, David, E-mail: [Instituto de Física, Pontificia Universidad Católica de Valparaíso, Casilla 4059, Valparaíso (Chile); Universidad Técnica Federico Santa María, Av. España 1680, Valparaíso (Chile)


    We construct exact hairy AdS soliton solutions in Einstein-dilaton gravity theory. We examine their thermodynamic properties and discuss the role of these solutions for the existence of first order phase transitions for hairy black holes. The negative energy density associated to hairy AdS solitons can be interpreted as the Casimir energy that is generated in the dual filed theory when the fermions are antiperiodic on the compact coordinate.

  4. Physico-mechanical and thermal performances of newly developed rubber-added bricks

    Energy Technology Data Exchange (ETDEWEB)

    Turgut, Paki [Harran University, Civil Engineering Department, 63300 Sanliurfa (Turkey); Yesilata, Bulent [Harran University, Mechanical Engineering Department, 63300 Sanliurfa (Turkey)


    The new European energy regulation now considers a high standard of thermal protection in buildings with reasonable energy consumption, satisfactory thermal comfort conditions and low operational costs. A series of significant restrictions on the disposal of used tires in landfills, stockpiles, or illegal dumping grounds are also imposed in recent European Union directives. The potential use of crumb rubber-concrete combination, in favor of these arrangements, for producing a low cost and lightweight composite brick with improved thermal resistance is examined here. The physico-mechanical and thermal insulation performances of these rubber-added bricks are investigated. The obtained compressive strength, flexural strength, splitting strength, freezing-thawing resistance, unit weight and water absorption values satisfy with the relevant international standards. The experimental observations reveal that high level replacement of crumb rubber with conventional sand aggregate does not exhibit a sudden brittle fracture even beyond the failure loads, indicates high energy absorption capacity, reduces the unit weight dramatically and introduces smoother surface compared to the current concrete bricks in the market. Thermal insulation performance is improved by introducing various amount of crumb rubber into the ordinary cementitious mixes. The percentage-wise improvements in thermal insulation performance have varied nearly between 5 and 11%, depending on the amount of crumb rubber used. (author)

  5. Development and sensory evaluation of yogurt added of “caviar” of carrot by children

    Directory of Open Access Journals (Sweden)

    Richtier Gonçalves Cruz


    Full Text Available This study aimed investigated to the preparation of yogurt with addition of “caviar” carrot and realize carried out sensory analysis of acceptance by children from elementary school. The “caviar” was prepared using the spherification technique with sodium alginate and added to the beaten-type yogurt without pulp addition at the ratio of one portion of the carrot for one portion of yogurt. Were conducted microbiological analyses and subsequently the sensory evaluation with children. The microbiological analyses showed that the product was fit for consumption. The average score in points obtained in the sensory analysis with 52 children was 6.7 (with 6.6 in males and 6.8 in females, it is that girls had higher scores (p < 0.05. The general index of acceptability to yogurt with “caviar” of carrot was 95.70%. It concludes that yogurt plus “caviar” carrot sensory was accepted because it presents high notes reflecting on their acceptability index, suggesting that this product is used as an alternative to increase the consumption of carrots by children.

  6. Lignocellulosic biorefinery as a model for sustainable development of biofuels and value added products. (United States)

    De Bhowmick, Goldy; Sarmah, Ajit K; Sen, Ramkrishna


    A constant shift of society's dependence from petroleum-based energy resources towards renewable biomass-based has been the key to tackle the greenhouse gas emissions. Effective use of biomass feedstock, particularly lignocellulosic, has gained worldwide attention lately. Lignocellulosic biomass as a potent bioresource, however, cannot be a sustainable alternative if the production cost is too high and/ or the availability is limited. Recycling the lignocellulosic biomass from various sources into value added products such as bio-oil, biochar or other biobased chemicals in a bio-refinery model is a sensible idea. Combination of integrated conversion techniques along with process integration is suggested as a sustainable approach. Introducing 'series concept' accompanying intermittent dark/photo fermentation with co-cultivation of microalgae is conceptualised. While the cost of downstream processing for a single type of feedstock would be high, combining different feedstocks and integrating them in a bio-refinery model would lessen the production cost and reduce CO2 emission. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index

    DEFF Research Database (Denmark)

    Aller, E E J G; Larsen, Thomas Meinert; Holst, Claus


    -month intervention period.Results:During the LCD period subjects lost 11.2 (10.8, 12.0) kg (mean (95% CI)). Average weight regain over the 12-month intervention period was 3.9 (95% CI 3.0 to 4.8) kg. Subjects on the HP diets regained less weight than subjects on the LP diets. The difference in weight......Background:A high dietary protein (P) content and low glycemic index (GI) have been suggested to be beneficial for weight management, but long-term studies are scarce.Objective:The DIOGENES randomized clinical trial investigated the effect of P and GI on weight loss maintenance in overweight...

  8. How Does That Work? Developing Pedagogical Content Knowledge from Subject Knowledge (United States)

    Hillier, Judith


    The development of subject knowledge and pedagogical content knowledge has been the focus of much educational research and debate in recent years. Of particular interest is the process by which preservice science teachers develop pedagogical content knowledge from their subject knowledge. In the study presented here, a process of writing narrative…

  9. Current status of AdS instability

    CERN Multimedia

    CERN. Geneva


    arXiv:1403.6471 and thoroughly developed in arXiv:1407.6273. On the other hand the negative cosmological constant allows for the existence of stable, time-periodic, asymptotically AdS solutions of Einstein equations [arXiv:1303.3186].

  10. Development of Nonaggregating Poly-A Tailed Immunostimulatory A/D Type CpG Oligodeoxynucleotides Applicable for Clinical Use

    Directory of Open Access Journals (Sweden)

    Taiki Aoshi


    Full Text Available Immunostimulatory CpG ODNs have been developed and utilized as TLR9-dependent innate immune activators and vaccine adjuvants. Four different types of immunostimulatory CpG ODNs (A/D, B/K, C, and P type have been reported. A/D type ODNs are characterized by high IFN-α production but intrinsically form aggregates, hindering its good manufacturing practice grade preparation. In this study, we developed several D35-derived ODNs (a commonly used A/D type ODN, which were modified with the addition of a phosphorothioate polynucleotide tail (such as dAs40, and examined their physical properties, solubility in saline, immunostimulatory activity on human PBMCs, and vaccine adjuvant potential in monkeys. We found that two modified ODNs including D35-dAs40 and D35core-dAs40 were immunostimulatory, similar to original D35 in human PBMCs, resulting in high IFN-α secretion in a dose-dependent manner. Physical property analysis by dynamic light scattering revealed that both D35-dAs40 and D35core-dAs40 did not form aggregates in saline, which is currently impossible for the original D35. Furthermore, D35-dAs40 and D35core-dAs40 worked as better vaccine adjuvant in monkeys. These results suggested that D35-dAs40 and D35core-dAs40 are two promising prototypes of nonaggregating A/D type ODN with advantages of ease of drug preparation for clinical applications as vaccine adjuvants or IFN-α inducing immunomodifiers.

  11. Development and testing of INSPIRE themes Addresses (AD) and Administrative Units (AU) managed by COSMC


    Michal Med; Petr Souček


    Main content of this article is to describe implementing INSPIRE themes Addresses and Administrative Units in Czech Republic. Themes were implemented by Czech Office for Surveying, Mapping and Cadastre. Implementation contains developing GML files with data and designing its structure, developing and testing of INSPIRE services and preparing metadata for data and services. Besides harmonised INSPIRE themes COSMC manages also non-harmonised themes Cadastral map (KM) and Units eXtended (UX).

  12. Recent progress in the development of solid catalysts for biomass conversion into high value-added chemicals (United States)

    Hara, Michikazu; Nakajima, Kiyotaka; Kamata, Keigo


    In recent decades, the substitution of non-renewable fossil resources by renewable biomass as a sustainable feedstock has been extensively investigated for the manufacture of high value-added products such as biofuels, commodity chemicals, and new bio-based materials such as bioplastics. Numerous solid catalyst systems for the effective conversion of biomass feedstocks into value-added chemicals and fuels have been developed. Solid catalysts are classified into four main groups with respect to their structures and substrate activation properties: (a) micro- and mesoporous materials, (b) metal oxides, (c) supported metal catalysts, and (d) sulfonated polymers. This review article focuses on the activation of substrates and/or reagents on the basis of groups (a)-(d), and the corresponding reaction mechanisms. In addition, recent progress in chemocatalytic processes for the production of five industrially important products (5-hydroxymethylfurfural, lactic acid, glyceraldehyde, 1,3-dihydroxyacetone, and furan-2,5-dicarboxylic acid) as bio-based plastic monomers and their intermediates is comprehensively summarized.

  13. Missing Link: Integrated Individual Leadership Development, Employee Engagement, and Customer Value-Added Improvement (United States)

    Heldenbrand, Lois; Simms, Michael S.


    Long-term care is a key public issue that affects all of us in some way at some time of our lives. Nowhere is performance improvement and quality management more imperative. Through an 8-month field study and follow-up case study, we discuss how using an integrated approach to individual leadership development, employee engagement, and customer…

  14. Development of the phosphorus and nitrogen containing flame retardant for value added cotton product (United States)

    It is our desire to develop new crosslinking agents for cotton textiles that afford useful flame protection regardless of fabric construction. Herein we present the synthesis and the application of the triazine and piperazine derivatives as flame retardant on cotton. Novel phosphorus-nitrogen contai...

  15. Creativity in ergonomic design: a supplemental value-adding source for product and service development. (United States)

    Zeng, Liang; Proctor, Robert W; Salvendy, Gavriel


    This article investigates the role of creativity in ergonomic design and the generic process of developing creative products and services. Creativity is gaining increased emphasis in both academia and industry. More than 50 years of research in creativity indicates that creativity is key to product and service innovation. Nevertheless, there is scarcely any comprehensive review dedicated to appraising the complex construct of creativity, the underlying cognitive process, and the role of creativity in product and service development. We review relevant literature regarding creativity, creative cognition, and the engineering design process to appraise the role of creativity in ergonomic design and to construct a conceptual model of creative product and service development. A framework of ergodesign creativity is advanced that highlights the central role of creativity in synergistically addressing the four dimensions of ergonomic design: functionality, safety, usability, and affectivity. A conceptual model of creative design process is then constructed that is goal oriented and is initiated by active problem finding and problem formulating. This process is carried out in a recursive and dynamic way, facilitated by creative thinking strategies. It is proposed that ergodesign creativity can add supplemental value to products and services, which subsequently affects consumer behavior and helps organizations gain competitive advantage. The proposed conceptual framework of ergodesign creativity and creative design process can serve as the ground for future theory development. Propositions advanced in this study should facilitate designers generating products and services that are creative and commercially competitive.

  16. Development of Value-Added Products from Residual Algae to Biomass

    Energy Technology Data Exchange (ETDEWEB)

    Behnke, Craig [Sapphire Energy, San Diego, CA (United States)


    DOE Award # EE0000393 was awarded to fund research into the development of beneficial uses of surplus algal biomass and the byproducts of biofuel production. At the time of award, Sapphire’s intended fuel production pathway was a fairly conventional extraction of lipids from biomass, resulting in a defatted residue which could be processed using anaerobic digestion. Over the lifetime of the award, we conducted extensive development work and arrived at the conclusion that anaerobic digestion presented significant technical challenges for this high-nitrogen, high-ash, and low carbon material. Over the same timeframe, Sapphire’s fuel production efforts came to focus on hydrothermal liquefaction. As a result of this technology focus, the residue from fuel production became unsuitable for either anaerobic digestion (or animal feed uses). Finally, we came to appreciate the economic opportunity that the defatted biomass could represent in the animal feed space, as well as understanding the impact of seasonal production on a biofuels extraction plant, and sought to develop uses for surplus biomass produced in excess of the fuel production unit’s capacity.

  17. White matter organization in relation to upper limb motor control in healthy subjects: exploring the added value of diffusion kurtosis imaging. (United States)

    Gooijers, J; Leemans, A; Van Cauter, S; Sunaert, S; Swinnen, S P; Caeyenberghs, K


    Diffusion tensor imaging (DTI) characterizes white matter (WM) microstructure. In many brain regions, however, the assumption that the diffusion probability distribution is Gaussian may be invalid, even at low b values. Recently, diffusion kurtosis imaging (DKI) was suggested to more accurately estimate this distribution. We explored the added value of DKI in studying the relation between WM microstructure and upper limb coordination in healthy controls (N = 24). Performance on a complex bimanual tracking task was studied with respect to the conventional DTI measures (DKI or DTI derived) and kurtosis metrics of WM tracts/regions carrying efferent (motor) output from the brain, corpus callosum (CC) substructures and whole brain WM. For both estimation models, motor performance was associated with fractional anisotropy (FA) of the CC-genu, CC-body, the anterior limb of the internal capsule, and whole brain WM (r s range 0.42-0.63). Although DKI revealed higher mean, radial and axial diffusivity and lower FA than DTI (p motor performance was associated with increased mean and radial kurtosis and kurtosis anisotropy (r s range 0.43-0.55). In conclusion, DKI provided additional information, but did not show increased sensitivity to detect relations between WM microstructure and bimanual performance in healthy controls.

  18. The diagram development for Computer Added Control and Monitoring system of drilling (United States)

    Epikhin, A. V.; Mikhalev, R. S.; Anisimov, A. V.; Ulyanova, O. S.


    The paper is concerned with the first stage of the extensive research aimed at developing design-automation system and well drilling process control. The proposed system is going to have some advantages over modern analogues, such as economic analysis at all levels, active engineering staff feedback, precedent-related principle for recommendations, etc. It will essentially reduce the risk of human errors and also optimize the well construction process from design to commissioning. The paper considers the results of the first design stage in a form of flow diagrams.

  19. Development of Subjective Recollection: Understanding of and Introspection on Memory States (United States)

    Ghetti, Simona; Mirandola, Chiara; Angelini, Laura; Cornoldi, Cesare; Ciaramelli, Elisa


    The development of subjective recollection was investigated in participants aged 6-18 years. In Experiment 1 (N = 90), age-related improvements were found in understanding of the subjective experience of recollection, although robust levels of understanding were observed even in the youngest group. In Experiment 2 (N = 100), age-related…

  20. Assessing Adolescents' Positive Psychological Functioning at School: Development and Validation of the Student Subjective Wellbeing Questionnaire (United States)

    Renshaw, Tyler L.; Long, Anna C. J.; Cook, Clayton R.


    This study reports on the initial development and validation of the Student Subjective Wellbeing Questionnaire (SSWQ) with a sample of 1,002 students in Grades 6-8. The SSWQ is a 16-item self-report instrument for assessing youths' subjective wellbeing at school, which is operationalized via 4 subscales measuring school connectedness, academic…

  1. Adding insult to injury: The development of psychosocial stress in Ontario wind turbine communities. (United States)

    Walker, Chad; Baxter, Jamie; Ouellette, Danielle


    Though historically dismissed as not-in-my-backyard (NIMBY) attitudes, reports of psychosocial stress linked to wind energy developments have emerged in Ontario, Canada. While the debate and rhetoric intensify concerning whether wind turbines 'actually' cause 'health' effects, less sincere attention has been given to the lived experience and mental well-being of those near turbines. Drawing on theories of environmental stress, this grounded theory, mixed-method (n = 26 interviews; n = 152 questionnaires) study of two communities in 2011 and 2012 traces how and why some wind turbine community residents suffer substantial changes to quality of life, develop negative perceptions of 'the other' and in some cases, experience intra-community conflict. Policy-related forces, along with existing community relationships may help explain much of these differences between communities. We suggest a move beyond debating simply whether or not 'annoyance' represents a 'health impact' and instead focus on ways to minimize and attenuate these feelings of threat (risk) and stress at the community level. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. Adding Value to Palliative Care Services: The Development of an Institutional Bereavement Program. (United States)

    Morris, Sue E; Block, Susan D


    Although bereavement programs are a common element of palliative medicine and hospice programs, few health care institutions currently offer universal bereavement services to all their patients. The elevated risk of serious physical and mental health problems among the bereaved is a strong argument for the development of universal institution-based bereavement programs as an element of quality care for family members of all patients who die. We describe the development of the bereavement program at Dana-Farber Cancer Institute (DFCI) where we conceptualized bereavement services as a preventive model of care. We identified education, guidance and support as the primary constructs of the program. The essential components include a formal acknowledgement of the death of the patient by the cancer center, information about grief and what to expect, individual visits to assess coping, and staff support and education. One hundred and forty bereaved families completed a survey about the bereavement program. The findings indicated that the formal letter of condolence and the bereavement guide had a positive impact on the grieving of the respondents. Contact from the patient's oncologist and nurse was especially well received. Bereavement programs can both help bereaved individuals adapt to their loss, and positively impact hospitals by enhancing the reputation of the hospital within the community and providing an avenue for identifying opportunities for improvement in care processes. We recommend that all hospitals implement basic bereavement programs for families of all deceased patients as the standard of care.

  3. A study on development of value added technology of pyrophyllite and dickite

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Keon-Joon; Choi, Yeon-Ho; Kim, Sang-Bae; Jeon, Ho-Seok; Cho, Sung-Baek [Korea Institute of Geology Mining and Materials, Taejon (Korea, Republic of)


    Pyrophyllite and dickite have being utilized as refractories, ceramics, cement, fiber glass, paper, rubber, paints etc.. However, there are not any domestic companies to produce fillers of pyrophyllite and dickite for plastic and rubber. Moreover, several kinds of fillers are imported every year with expensive price for plastic and rubber filler. This study has purpose to develop manufacturing technologies to produce fillers for plastic and rubber of pyrophyllite and dickite. The chemical and mineralogical properties of samples, the optimum grinding condition and device for producing plastic fillers and development of technology of improvement in whiteness, and the optimum synthesis condition of zeolite Y are the scopes and contents of the study. Pyrophyllite samples are taken from Bunam. Principal composed minerals are pyrophyllite, quartz and dickite, having chemical components of 9.2% Al{sub 2}O{sub 3}, 74.8% SiO{sub 2}, and 0.1% Fe{sub 2}O{sub 3}, respectively. Dickite sample is taken from Bugok, consists of dickite and quartz having 37.7% Al{sub 2}O{sub 3}, 47.8% SiO{sub 2} and 0.04% Fe{sub 2}O{sub 3}. Efficiency of the vibrating mill proved to be greater than ball mill compare with median size. The whiteness of sample increased with roasting temperature. In grinding a Bunam and Bugok sample by vibrating mill for 180 minute, median particle size is 3.06{mu}m and 2.85{mu}m, respectively. The structure water dehydration temperature is about 600 deg.C and mullite is presented around 850 deg.C for dickite, and the whiteness increased with roasting temperature. The whiteness of Bunam and Bugok sample ground by vibrating mill for 180 minute and roasted for 60 minutes at 900 deg.C is 96.5, 98, respectively. The mole ratio of SiO{sub 2}/Al{sub 2}O{sub 3} is important factor for synthesis of zeolite Y, crystallinity is 56 at SiO{sub 2}/Al{sub 2}O{sub 3} mole ratio is 13. Reaction time also important factor, crystallinity is 52 at SiO{sub 2}/Al{sub 2}O{sub 3} mole ratio

  4. Adding insult to injury: development and initial validation of the Partner-Directed Insults Scale. (United States)

    Goetz, Aaron T; Shackelford, Todd K; Schipper, Lucas D; Stewart-Williams, Steve


    Women who are verbally abused by their intimate male partners suffer serious mental health consequences and often experience physical violence in their relationship. Despite the importance of studying verbal abuse, no previous research has investigated the specific content of the insults men use to derogate their partners. We present the development and initial validation of a new measure designed to assess the specific content of insults used by men against their intimate partners. In a preliminary study, we used feedback from battered women, along with a review of the relevant literature, to identify specific insults for inclusion in the Partner-Directed Insults Scale (PDIS). We administered the PDIS to a sample of United States participants (Study 1) and a sample of New Zealand participants (Study 2), allowing for a cross-national investigation of the specific insults that men use to derogate their partners. The results demonstrate the practical need for such a scale and provide evidence for the discriminant validity of the PDIS by documenting that men's use of insults predicts their use of controlling behaviors and physical violence.

  5. Decoding development in the XXI century: subjectivity, complexity, sinapsis, sinergy, recursivity, lidership and territorial dependency

    National Research Council Canada - National Science Library

    Sergio Boisier


      BOISIER, Sergio. Decoding development in the XXI century: subjectivity, complexity, sinapsis, sinergy, recursivity, lidership and territorial dependency. Semest. Econ. [online]. 2010, vol.13, n.27, pp. 11-37. ISSN 0120-6346...

  6. Development and characterization of collagen films with added essential oil of clove india

    Directory of Open Access Journals (Sweden)

    Ailim Yuki Nakashima


    Full Text Available This objective of this study was to develop and characterized films based on collagen and analyze the effects of concentrations of clay, plasticizer and essential oil on its characteristics. The solutions were prepared according to an experimental design of 2³ with 3 central points. The films were produced by the "casting" technique, which consists on surface drying, and were characterized by the color, opacity, tensile strength, solubility, water vapor permeability and thickness. Lightness values ranged between 66.76 and 96.03, the brightness decreased with increasing the concentrations of clay, oil and glycerol. The opacity values showed an increase with the addition of glycerol, ranging from 1.96 to 44.24%. The values of tensile strength ranged from 5 to 14 MPa, and the solubility values, from 2.14 to 7.97%. In the 5% level, solubility and tensile strength analyzes were not significant. The water vapor permeability (WVP ranged from 0.77 to 2.51 ( The most influent factors on the permeability to water vapor in the films are the glycerol and essential oil concentrations, which increases the permeability as these variables increase. In relation to the thickness, the concentration of montmorillonite clay interfered in the range from 0.02 to 0.04mm, and as higher its concentration, greater the thickness. It was concluded that the collagen films obtained good mechanical properties, adequate visual appearance, easy handing and low permeability to water vapor and low water solubility. The essential oil was effective in the structure of the film, since that it improves the look and easier handling.

  7. Efficacy of yogurt drink with added plant stanol esters (Benecol®, Colanta) in reducing total and LDL cholesterol in subjects with moderate hypercholesterolemia: a randomized placebo-controlled crossover trial NCT01461798. (United States)

    Vásquez-Trespalacios, Elsa M; Romero-Palacio, Johanna


    Cardiovascular diseases have become the leading cause of death from chronic diseases in the world. Main risk factors include hypercholesterolemia, which is caused in most cases by a high saturated fat diet. Plant stanol esters partly block cholesterol absorption in the digestive tract and thereby reduce total cholesterol and low-density lipoprotein (LDL) cholesterol serum levels. Based on epidemiological data, a 10 percent reduction of LDL cholesterol leads to a 20 percent decrease in the coronary heart disease risk throughout life. The aim of this study was to evaluate the efficacy of yogurt drink with added plant stanol esters (Benecol® yogurt drink) in higher doses than the typically used (2g/d stanols), in lowering blood lipids in moderately hypercholesterolemic subjects. A randomized double-blind crossover, placebo-controlled study in moderately hypercholesterolemic subjects (n = 40) aged between 20 and 50 years old. Yogurt drink with added plant stanols (4 g) as esters (Benecol®, Colanta) consumption compared to regular yogurt drink caused a statistically significant decrease in total cholesterol and low density lipoprotein cholesterol by 7.2% and 10.3%. During the two periods and compared to controls, high-density lipoprotein cholesterol and triglycerides were not significantly different. Yogurt drink with an active ingredient in Benecol®, plant stanol esters, reduced total cholesterol and LDL cholesterol in moderately hypercholesterolemic subjects. NCT01461798.


    Directory of Open Access Journals (Sweden)

    Ol'ga L. Zadvornaya


    Full Text Available The article is devoted to the problem of development of professional-subjective position of managerial staff of health care in the system of continuous professional education in the conditions of optimization of activities of the health system. Professional and subject position reflects the position of individual managers in a professional environment, its relationship to the quality of professional activity, to himself, to patients and colleagues to level their skills.Purpose/objectives: analysis of core competencies, forming the professional and subject position of heads of medical organizations; identify possible ways of development of professional-subjective position of managerial staff of the public health based on the use of modern technologies and active methods of training in system of continuous professional education. Methodology. In conducting the present study used data from official sources, literature review, scientific methods of analysis and synthesis, comparative analysis and modeling. The results of the study indicate the necessity of actualization of the subject position of heads of medical organizations. Conclusions /Significance. The necessity of formation and development of professional subjective position of the heads due to the needs of society and the health care system with modern requirements for quality management training of health. Professional and subject position is a characteristic feature of a highly qualified specialist in the area of governance, reflecting its active attitude toward self and professional activity, factor of efficiency of activity of medical organizations. The real practice of activity of medical organizations requires improved approaches in the preparation of healthcare managers. Most of the leaders are having difficulties, associated not only with necessity of development of universal and professional competences, but also the necessity of development of professional-subjective position

  9. Recent developments in thermally-driven seawater desalination: Energy efficiency improvement by hybridization of the MED and AD cycles

    KAUST Repository

    Ng, Kim Choon


    The energy, water and environment nexus is a crucial factor when considering the future development of desalination plants or industry in the water-stressed economies. New generation of desalination processes or plants has to meet the stringent environment discharge requirements and yet the industry remains highly energy efficient and sustainable when producing good potable water. Water sources, either brackish or seawater, have become more contaminated as feed while the demand for desalination capacities increase around the world. One immediate solution for energy efficiency improvement comes from the hybridization of the proven desalination processes to the newer processes of desalination: For example, the integration of the available thermally-driven to adsorption desalination (AD) cycles where significant thermodynamic synergy can be attained when cycles are combined. For these hybrid cycles, a quantum improvement in energy efficiency as well as in increase in water production can be expected. The advent of MED with AD cycles, or simply called the MEDAD cycles, is one such example where seawater desalination can be pursued and operated in cogeneration with the electricity production plants: The hybrid desalination cycles utilize only the low exergy bled-steam at low temperatures, complemented with waste exhaust or renewable solar thermal heat at temperatures between 60 and 80. °C. In this paper, the authors have reported their pioneered research on aspects of AD and related hybrid MEDAD cycles, both at theoretical models and experimental pilots. Using the cogeneration of electricity and desalination concept, the authors examined the cost apportionment of fuel cost by the quality or exergy of working steam for such cogeneration configurations.

  10. Towards Development of Robotic Aid for Rehabilitation of Locomotion-Impaired Subjects (United States)

    Bejczy, Antal K.


    Manual assistance of therapists to help movement of legs of spinal cord injured (SCI) subjects during stepping on a treadmill for locomotion rehabilitation has severe economic and technical limitations. Scientists at the Department of Physiological Science at the University of California Los Angeles (UCLA) and roboticists at the Jet Propulsion Laboratory (JPL) initiated a joint effort to develop a robotic mechanism capable of performing controlled motions equivalent to the arm and hand motions of therapists assisting the stepping of locomotion impaired subjects on a treadmill, while the subjects' body weight is partially supported by an overhead harness. A first necessary technical step towards this development is to measure and understand the kinematics and dynamics of the therapists' arm and hand motions as they are reflected on the subjects' leg movement. This paper describes an initial measurement system developed for this purpose together with the related measurement results, and outlines the planned future technical work.

  11. Adding Ajax

    CERN Document Server

    Powers, Shelley


    Ajax can bring many advantages to an existing web application without forcing you to redo the whole thing. This book explains how you can add Ajax to enhance, rather than replace, the way your application works. For instance, if you have a traditional web application based on submitting a form to update a table, you can enhance it by adding the capability to update the table with changes to the form fields, without actually having to submit the form. That's just one example.Adding Ajax is for those of you more interested in extending existing applications than in creating Rich Internet Applica

  12. Subjective wellbeing and income: Empirical patterns in the rural developing world (United States)

    Reyes-García, Victoria; Babigumira, Ronnie; Pyhälä, Aili; Wunder, Sven; Zorondo-Rodríguez, Francisco; Angelsen, Arild


    A commonality in the economics of happiness literature is that absolute income matters more for the subjective wellbeing of people at low income levels. In this article, we use a large sample of people in rural areas of developing countries with relatively low income levels to test whether subjective wellbeing an increasing function of absolute income in our sample, and to analyze the existence of adaptation and social comparison effects on subjective wellbeing. Our sample includes 6973 rural households in 23 countries throughout Asia, Africa, and Latin America. The average total income per adult equivalent in our sample was US$1555, whereas levels of subjective wellbeing resembled levels found in previous research using cross-country data. We find that, despite low levels of absolute income, levels of subjective wellbeing of our respondents resemble levels found in previous research using cross-country data. We also find remarkable similarities in many of the determinants of subjective wellbeing previously tested. Our data show that absolute income covariates with subjective wellbeing, but -as for richer samples- the magnitude of the association is lower once we control for adaptation and social comparison. Finally, our results suggest that social comparison has a stronger effect than adaptation in explaining the subjective wellbeing of our sample. Our findings highlight the importance of adaptation and social comparison even at low levels of absolute income. PMID:27642259

  13. Value-added probiotic development by high-solid fermentation of sweet potato withSaccharomyces boulardii. (United States)

    Campbell, Carmen; Nanjundaswamy, Ananda K; Njiti, Victor; Xia, Qun; Chukwuma, Franklin


    Controlled fermentation of Sweet potato ( Ipomoea batatas ) var. Beauregard by yeast, Saccharomyces boulardii (MAY 796) to enhance the nutritional value of sweet potato was investigated. An average 8.00 × 10 10 Colony Forming Units (CFU)/g of viable cells were obtained over 5-day high-solid fermentation. Yeast cell viability did not change significantly over time at 4°C whereas the number of viable yeast cells reduced significantly at room temperature (25°C), which was approximately 40% in 12 months. Overall, the controlled fermentation of sweet potato by MAY 796 enhanced protein, crude fiber, neutral detergent fiber, acid detergent fiber, amino acid, and fatty acid levels. Development of value-added sweet potato has a great potential in animal feed and human nutrition. S. boulardii - fermented sweet potato has great potential as probiotic-enriched animal feed and/or functional food for human nutrition.

  14. Social existence: between subjective and objective conditions. Impact on the theoretical discussion on development

    Directory of Open Access Journals (Sweden)

    Aura González Serna


    Full Text Available This article aims to instill reflections on the theoretical debate around the development. The premise for fixing the analysis is to consider the impact of modes of apprehending social existence, since it is demarcated between subjectivities and objective conditions. Different conceptions appear to interpret and represent the individual and collective imagination. Fragmentation between subjectivity and objectivity, constitute an impediment to understanding the generic nature of being that builds and permanently transformed the social existence.

  15. The political attack ad

    Directory of Open Access Journals (Sweden)

    Palma Peña-Jiménez, Ph.D.


    Full Text Available During election campaigns the political spot has a clear objective: to win votes. This message is communicated to the electorate through television and Internet, and usually presents a negative approach, which includes a direct critical message against the opponent, rather than an exposition of proposals. This article is focused on the analysis of the campaign attack video ad purposely created to encourage the disapproval of the political opponent among voters. These ads focus on discrediting the opponent, many times, through the transmission of ad hominem messages, instead of disseminating the potential of the political party and the virtues and manifesto of its candidate. The article reviews the development of the attack ad since its first appearance, which in Spain dates back to 1996, when the famous Doberman ad was broadcast, and examines the most memorable campaign attack ads.

  16. [Development of mixed beverages made of caja (Spondias mombin L.) and cashew apple (Anacardium occidentale) added of fructooligosaccharides and inulin]. (United States)

    Silva, Larissa Morais Ribeiro da; Lima, Andréa da Silva; Maia, Geraldo Arraes; Rodrigues, Maria do Carmo Passos; Figueiredo, Raimundo Wilane de; Sousa, Paulo Henrique Machado de


    The purpose of this work was to develop three mixed drinks based on caja (Spondias mombin L.) and cashew apple (Anacardium occidentale) pulps, added prebiotic ingredients and to evaluate their chemical, physicochemical and sensory properties. Four formulations with combinations of two pulp fruit, sucrose and prebiotic ingredients (Standard inulin, inulin high performance-HP-and fructooligosaccharides FOS) were developed. The mixed drinks were submitted the following analysis pH, acidity, soluble solids, sugars, ascorbic acid, total carotenoids, total polyphenols and acceptance ratings of the sensory attributes such as: consistency, sweetness and overall impression, attitude and consumers purchase preference. The pH, total soluble solids and polyphenol results showed difference (p analysis of total acidity, sugars, ascorbic acid and carotenoids, it was not observed significant difference. The sensory attributes evaluates showed results ranging in scale between "I did not like or disliked "and" liked "(average 5.80 to 7.06). The attributes sweetness, consistency and attitude of buying showed no difference (p > 0.05) between drinks, however, differed significantly (p < or = 0.05) for the attribute of overall impression. The drink with FOS showed a similar acceptance when compared to traditional (sucrose) drink, showing an option of meeting the functional food expectations of consumers, who seek healthy, nutritious and tasty foods.

  17. Subject- and Experience-Bound Differences in Teachers' Conceptual Understanding of Sustainable Development (United States)

    Borg, C.; Gericke, N.; Höglund, H.-O.; Bergman, E.


    This article describes the results of a nationwide questionnaire study of 3229 Swedish upper secondary school teachers' conceptual understanding of sustainable development in relation to their subject discipline and teaching experience. Previous research has shown that teachers have difficulties understanding the complex concept of sustainable…

  18. "Biosphere Reserve"--The Actual Research Subject of the Sustainable Development Process" (United States)

    Khasaev, Gabibulla R.; Sadovenko, Marina Yu.; Isaev, Roman O.


    The relevance of the analyzed issue is caused by the growing slippage of research funds of sustainable development in its practice. The purpose of the article is the theoretical basis of the biosphere reserve as a scientific research subject that is relevant to rules of the scientific activity. The leading approach to the study of this issue is…

  19. Satisfaction with travel and subjective well-being: development and test of a measurement tool

    NARCIS (Netherlands)

    Ettema, D.F.; Gärling, T.; Eriksson, L.; Friman, M.; Olsson, L.E.; Fujii, S.


    Subjective well-being (SWB) that includes individuals’ cognitive and affective evaluations of life in general is proposed to be a more appropriate measure capturing the benefits individuals derive from travel improvements. We develop and testa measure of travel-related SWB, the nine item self-report

  20. 86Rubidium uptake in mononuclear leucocytes from young subjects at increased risk of developing essential hypertension

    DEFF Research Database (Denmark)

    Nielsen, J R; Johansen, Torben; Pedersen, K E


    parents. 86Rubidium uptake was significantly increased in the borderline hypertensive subjects, especially in the borderline hypertensive offspring of hypertensive patients. Our results indicate that the sodium-potassium pump is activated in mononuclear leucocytes from borderline hypertensives......, and especially in those borderline hypertensives with at least one hypertensive parent. The latter group was also the group at greatest risk of developing essential hypertension....

  1. Adding more value to added-value

    DEFF Research Database (Denmark)

    Marian, Livia

    Recent studies reveal that consumers respond favourably to “organic plus” products with additional ethical attributes. The aim of the current study is to explore whether consumers would notice and value further improvements in the animal welfare standards than those imposed by the organic...... it is probably valued less than expected. The added attributes need to be thoroughly considered when developing and marketing “organic plus” products, as their effect on other product characteristics (e.g. high prices) can detract from their added value....

  2. Lung function and breathing pattern in subjects developing high altitude pulmonary edema.

    Directory of Open Access Journals (Sweden)

    Christian F Clarenbach

    Full Text Available INTRODUCTION: The purpose of the study was to comprehensively evaluate physiologic changes associated with development of high altitude pulmonary edema (HAPE. We tested whether changes in pulmonary function and breathing pattern would herald clinically overt HAPE at an early stage. METHODS: In 18 mountaineers, spirometry, diffusing capacity, nitrogen washout, nocturnal ventilation and pulse oximetry were recorded at 490 m and during 3 days after rapid ascent to 4559 m. Findings were compared among subjects developing HAPE and those remaining well (controls. RESULTS: In 8 subjects subsequently developing radiographically documented HAPE at 4559 m, median FVC declined to 82% of low altitude baseline while closing volume increased to 164% of baseline (P<0.05, both instances. In 10 controls, FVC decreased slightly (to 93% baseline, P<0.05 but significantly less than in subjects with HAPE and closing volume remained unchanged. Sniff nasal pressure was reduced in both subjects with and without subsequent HAPE. During nights at 4559 m, mean nocturnal oxygen saturation dropped to lower values while minute ventilation, the number of periodic breathing cycles and heart rate were higher (60%; 8.6 L/min; 97 cycles/h; 94 beats/min, respectively in subjects subsequently developing HAPE than in controls (73%; 5.1 L/min; 48 cycles/h; 79 beats/min; P<0.05 vs. HAPE, all instances. CONCLUSION: The results comprehensively represent the pattern of physiologic alterations that precede overt HAPE. The changes in lung function are consistent with reduced lung compliance and impaired gas exchange. Pronounced nocturnal hypoxemia, ventilatory control instability and sympathetic stimulation are further signs of subsequent overt HAPE.

  3. Development of Web Based Learning Material in Physics Subject for Kalor and Temperature Material

    Directory of Open Access Journals (Sweden)

    Fatwa Aji Kurniawan


    Full Text Available It has been done, the research which aims to develop a web-based teaching materials on the subjects of physics subject with subject mater of temperature and heat. This study using a modified model of the 4D development by eliminating the deployment phase. The validation of product development conducted by validator media experts and experts matter of physics, whereas small-scale trials conducted by physics teacher and 10 students. Validator review results stating that the quality of the product development were included in the category very well with the average percentage rating of 83.93%. The percentage value assigned by media expert by 75% in the good category and the percentage of the value provided by a matter expert 92.85% were in the very good category. Experiments by physics teacher to obtain result of equal to 94.44% were in the very good category and the average percentage of the test results by the students of 90.5% were in the very good category. The characteristics of the products developed include material composition using the curriculum in 2013, there was a recording facility and the results of evaluation of students' activities, there were feedback evaluation results were immediately known by the students and there were some links related to the material either youtube or other learning website.

  4. Training-related brain plasticity in subjects at risk of developing Alzheimer's disease. (United States)

    Belleville, Sylvie; Clément, Francis; Mellah, Samira; Gilbert, Brigitte; Fontaine, Francine; Gauthier, Serge


    Subjects with mild cognitive impairment are at risk of developing Alzheimer's disease. Cognitive stimulation is an emerging intervention in the field of neurology and allied sciences, having already been shown to improve cognition in subjects with mild cognitive impairment. Yet no studies have attempted to unravel the brain mechanisms that support such improvement. This study uses functional magnetic resonance imaging to measure the effect of memory training on brain activation in older adults with mild cognitive impairment and to assess whether it can reverse the brain changes associated with mild cognitive impairment. Brain activation associated with verbal encoding and retrieval was recorded twice prior to training and once after training. In subjects with mild cognitive impairment, increased activation was found after training within a large network that included the frontal, temporal and parietal areas. Healthy controls showed mostly areas of decreased activation following training. Comparison with pre-training indicated that subjects with mild cognitive impairment used a combination of specialized areas; that is, areas activated prior to training and new alternative areas activated following training. However, only activation of the right inferior parietal lobule, a new area of activation, correlated with performance. Furthermore, the differences between the brain activation patterns of subjects with mild cognitive impairment and those of healthy controls were attenuated by training in a number of brain regions. These results indicate that memory training can result in significant neural changes that are measurable with brain imaging. They also show that the brains of people with mild cognitive impairment remain highly plastic.

  5. Mobile ad hoc networking

    CERN Document Server

    John Wiley & Sons


    "Assimilating the most up-to-date information on research and development activities in this rapidly growing area, Mobile Ad Hoc Networking covers physical, data link, network, and transport layers, as well as application, security, simulation, and power management issues in sensor, local area, personal, and mobile ad hoc networks. Each of the book's sixteen chapters has been written by a top expert and discusses in-depth the most important topics in the field. Mobile Ad Hoc Networking is an excellent reference and guide for professionals seeking an in-depth examination of topics that also provides a comprehensive overview of the current state-of-the-art."--Jacket.

  6. Development of a credit-bearing service leadership subject for university students in Hong Kong. (United States)

    Shek, Daniel T L; Yu, Lu; Ma, Cecilia M S; Sun, Rachel C F; Liu, Ting Ting


    Given that service industries contribute to 93% of Hong Kong's GDP, an important question that should be asked is whether the education system can promote the development of service leadership among young people in Hong Kong. Unfortunately, service leadership programs specifically designed for university students are lacking in Hong Kong. In this paper, the basic tenets of the Service Leadership and Management framework are presented. Based on the fundamental postulation that effective service leadership is a function of moral character, competence and care (E=MC(2)), a subject called "Service Leadership" has recently been developed at The Hong Kong Polytechnic University. This paper outlines the objectives, intended learning outcomes, syllabus, assessment, and references of the subject. The proposed evaluation strategies are also described.

  7. Recognition and development of "educational technology" as a scientific field and school subject


    Danilović Mirčeta S.


    The paper explores the process of development, establishment and recognition of "educational technology" as an independent scientific field and a separate teaching subject at universities. The paper points to: (a) the problems that this field deals with or should deal with, (b) knowledge needed for the profession of "educational technologist", (c) various scientific institutions across the world involved in educational technology, (d) scientific journals treating issues of modern educational ...

  8. Exergy in the built environment. The added value of exergy in the assessment and development of energy systems for the built environment.

    NARCIS (Netherlands)

    Jansen, S.C.


    This doctoral research studied the added value of exergy for the assessment and development of energy systems for the built environment, aiming at a reduced need for high-quality energy input. Currently the analysis and development of energy systems for the built environment is based on the energy

  9. Added Sugars (United States)

    ... Preschoolers Infographic How to Make a Healthy Home Dietary Recommendations for Healthy Children Top 10 Tips to Help Children Develop Healthy Habits Fruit and Veggie Toolkit for Kids Healthy Foods ...

  10. Therapeutic misconception in research subjects: development and validation of a measure. (United States)

    Appelbaum, Paul S; Anatchkova, Milena; Albert, Karen; Dunn, Laura B; Lidz, Charles W


    Therapeutic misconception (TM), which occurs when research subjects fail to appreciate the distinction between the imperatives of clinical research and ordinary treatment, may undercut the process of obtaining meaningful consent to clinical research participation. Previous studies have found that TM is widespread, but progress in addressing TM has been stymied by the absence of a validated method for assessing its presence. The goal of this study was to develop and validate a theoretically grounded measure of TM, assess its diagnostic accuracy, and test previous findings regarding TM's prevalence. A total of 220 participants were recruited from clinical trials at four academic medical centers in the United States. Participants completed a 28-item Likert-type questionnaire to assess the presence of beliefs associated with TM, and a semistructured TM interview designed to elicit their perceptions of the nature of the clinical trial in which they were participating. Data from the questionnaires were subjected to factor analysis, and items with poor factor loadings were excluded. This resulted in a 10-item scale, with three strongly correlated factors and excellent internal consistency; the fit indices of the model across 10 training sets were consistent with the original results, suggesting a stable factor solution. The scale was validated against the TM interview, with significantly higher scores among subjects coded as displaying evidence of TM. Receiver operating curve (ROC) analysis based on a 10-fold internal cross-validation yielded area under the ROC (AUC) = 0.682 for any evidence of TM. When sensitivity (0.72) and specificity (0.61) were both optimized, positive predictive value was 0.65 and negative predictive value was 0.68, with a positive likelihood ratio of 1.89 and a negative likelihood ratio of 0.47. In all, 50.5% (n = 101) of the participants manifested evidence of TM on the TM interview, a somewhat lower rate than in most previous studies. The

  11. Recognition and development of "educational technology" as a scientific field and school subject

    Directory of Open Access Journals (Sweden)

    Danilović Mirčeta S.


    Full Text Available The paper explores the process of development, establishment and recognition of "educational technology" as an independent scientific field and a separate teaching subject at universities. The paper points to: (a the problems that this field deals with or should deal with, (b knowledge needed for the profession of "educational technologist", (c various scientific institutions across the world involved in educational technology, (d scientific journals treating issues of modern educational technology, (e the authors i.e. psychologists and educators who developed and formulated the basic principles of this scientific field, (f educational features and potentials of educational technologies. Emphasis is placed on the role and importance of AV technology in developing, establishing and recognition of educational technology, and it is also pointed out that AV technology i.e. AV teaching aids and a movement for visualization of teaching were its forerunners and crucial factors for its establishing and developing into an independent area of teaching i.e. school subject. In summary it is stressed that educational technology provides for the execution of instruction through emission transmission, selection, coding, decoding, reception, memorization transformation of all types of pieces of information in teaching.

  12. The Subject and the Setting: Re-Imagining Opportunities for Primary Teachers' Subject Knowledge Development on School-Based Teacher Education Courses (United States)

    Knight, Rupert


    The landscape of teacher education is undergoing significant change in many countries and this is often associated with a move towards greater school involvement in the preparation of teachers. One aspect of teaching expertise that is particularly challenging for primary student-teachers is the development of subject knowledge across a wide range…

  13. Development of ICT competences in the environmental studies subject in Slovenia

    Directory of Open Access Journals (Sweden)

    Vlasta Husa


    Full Text Available Digital literacy is one of eight key competences that were defined by the European Parliament and Council as those that member states should develop as a part of their strategies for lifelong learning (Official Journal of the European Union, 2006, p.11. It would contribute to a more successful life in a knowledge society. The purpose of this paper is to Npresent the results of empirical research on the use of ICT in the lessons of the environmental studies subject in the first triennium of primary schools in the Republic of Slovenia. Data were collected through a questionnaire and according to the protocol. We found that among all of the ICT tools, teachers mostly use the computer. The majority of the teachers use the computer once a week, most often in mathematics and environmental studies subject. In the observed lessons of the environmental studies subject, less than half of teachers use the computer in the lessons. This was followed by the use of computer and the LCD projector, and the interactive whiteboard. Among the obstacles that teachers indicate when they try to include ICT in the learning process are insufficient, out of date equipment, lack of time and lack of their own competence.

  14. Empirical Model Development for Predicting Shock Response on Composite Materials Subjected to Pyroshock Loading (United States)

    Gentz, Steven J.; Ordway, David O; Parsons, David S.; Garrison, Craig M.; Rodgers, C. Steven; Collins, Brian W.


    The NASA Engineering and Safety Center (NESC) received a request to develop an analysis model based on both frequency response and wave propagation analyses for predicting shock response spectrum (SRS) on composite materials subjected to pyroshock loading. The model would account for near-field environment (approx. 9 inches from the source) dominated by direct wave propagation, mid-field environment (approx. 2 feet from the source) characterized by wave propagation and structural resonances, and far-field environment dominated by lower frequency bending waves in the structure. This report documents the outcome of the assessment.

  15. Empirical Model Development for Predicting Shock Response on Composite Materials Subjected to Pyroshock Loading: Appendices (United States)

    Gentz, Steven J.; Ordway, David O.; Parsons, David S.; Garrison, Craig M.; Rodgers, C. Steven; Collins, Brian W.


    The NASA Engineering and Safety Center (NESC) received a request to develop an analysis model based on both frequency response and wave propagation analyses for predicting shock response spectrum (SRS) on composite materials subjected to pyroshock loading. The model would account for near-field environment (approx. 9 inches from the source) dominated by direct wave propagation, mid-field environment (approx. 2 feet from the source) characterized by wave propagation and structural resonances, and far-field environment dominated by lower frequency bending waves in the structure. This document contains appendices to the Volume I report.

  16. Empirical Model Development for Predicting Shock Response on Composite Materials Subjected to Pyroshock Loading. [Appendices (United States)

    Gentz, Steven J.; Ordway, David O.; Parsons, David S.; Garrison, Craig M.; Rodgers, C. Steven; Collins, Brian W.


    The NASA Engineering and Safety Center (NESC) received a request to develop an analysis model based on both frequency response and wave propagation analyses for predicting shock response spectrum (SRS) on composite materials subjected to pyroshock loading. The model would account for near-field environment (9 inches from the source) dominated by direct wave propagation, mid-field environment (approximately 2 feet from the source) characterized by wave propagation and structural resonances, and far-field environment dominated by lower frequency bending waves in the structure. This document contains appendices to the Volume I report.

  17. Development, Validity and Reliability of the Londrina Activities of Daily Living Protocol for Subjects With COPD. (United States)

    Sant'Anna, Thaís; Donária, Leila; Furlanetto, Karina C; Morakami, Fernanda; Rodrigues, Antenor; Grosskreutz, Talita; Hernandes, Nidia A; Gosselink, Rik; Pitta, Fabio


    To avoid symptoms, patients with COPD may reduce the amount of activities of daily living (ADL). Therefore, the aim of the present study was to develop a standardized protocol to evaluate ADL performance in subjects with COPD (Londrina ADL protocol) and to assess the validity and reliability of the protocol in this population. The Londrina ADL protocol was created based on activities included in previous studies aimed at investigating outcomes from ADL. Activities were included in the protocol because they could represent other activities of similar patterns and because they could be actually performed, not simulated. Twenty subjects with COPD (12 men, 70 ± 7 y old, FEV1 = 54 ± 15% predicted) wore 2 motion sensors while performing the protocol 4 times, 2 of them wearing a portable gas analyzer. Subjects were also submitted to assessments of lung function, functional exercise capacity, functional status, impact on health status, and physical activity in daily life. The Londrina ADL protocol comprised of 5 activities representing ADL, involving upper limbs, lower limbs, and trunk movements. Londrina ADL protocol duration presented high values of intraclass correlation coefficient, even using a mask for gas analysis (intraclass correlation coefficient >0.90, P < .001). Intensity of movement during the protocol performance was highly correlated to intensity of movement in daily life (r = 0.71). The protocol duration was correlated with functional status and impact on health status variables from questionnaires (0.36 ≤ r ≤ 0.59). There was also correlation between functional exercise capacity and the protocol duration (r = -0.64). The Londrina ADL protocol was a valid and reliable protocol to evaluate ADL performance in subjects with COPD. It is a protocol that can be used in clinical practice and in future studies to investigate ADL outcomes, including those studies that require gas analysis and the wearing of a mask. Copyright © 2017 by Daedalus Enterprises.

  18. Value Added in English Schools


    Andrew Ray; Tanya McCormack; Helen Evans


    Value-added indicators are now a central part of school accountability in England, and value-added information is routinely used in school improvement at both the national and the local levels. This article describes the value-added models that are being used in the academic year 2007–8 by schools, parents, school inspectors, and other professionals in local and national governments. The article outlines the development of value-added models in England following the introduction of national t...

  19. Development and optimization of a noncontact optical device for online monitoring of jaundice in human subjects (United States)

    Polley, Nabarun; Saha, Srimoyee; Singh, Soumendra; Adhikari, Aniruddha; Das, Sukhen; Choudhury, Bhaskar Roy; Pal, Samir Kumar


    Jaundice is one of the notable markers of liver malfunction in our body, revealing a significant rise in the concentration of an endogenous yellow pigment bilirubin. We have described a method for measuring the optical spectrum of our conjunctiva and derived pigment concentration by using diffused reflection measurement. The method uses no prior model and is expected to work across the races (skin color) encompassing a wide range of age groups. An optical fiber-based setup capable of measuring the conjunctival absorption spectrum from 400 to 800 nm is used to monitor the level of bilirubin and is calibrated with the value measured from blood serum of the same human subject. We have also developed software in the LabVIEW platform for use in online monitoring of bilirubin levels in human subjects by nonexperts. The results demonstrate that relative absorption at 460 and 600 nm has a distinct correlation with that of the bilirubin concentration measured from blood serum. Statistical analysis revealed that our proposed method is in agreement with the conventional biochemical method. The innovative noncontact, low-cost technique is expected to have importance in monitoring jaundice in developing/underdeveloped countries, where the inexpensive diagnosis of jaundice with minimally trained manpower is obligatory.

  20. The pharmaceutical industry's responsibility for protecting human subjects of clinical trials in developing nations. (United States)

    Kelleher, Finnuala


    Pharmaceutical companies increasingly perform clinical trials in developing nations. Governments of host nations see the trials as a way to provide otherwise unaffordable medical care, while trial sponsors are drawn to those countries by lower costs, the prevalence of diseases rare in developed nations, and large numbers of impoverished patients. Local governments, however, fail to police trials, and the FDA does not monitor trials in foreign countries, resulting in the routine violation of international standards for the protection of human subjects. This Note proposes independent accreditation of those institutions involved in clinical trials--the institutional review boards which oversee trial protocol; the organizations, such as pharmaceutical companies, which sponsor the trials; and the research organizations that conduct the trials. Accreditation, similar to that used in the footwear and apparel industries, would increase the transparency of pharmaceutical trials and would enable the United States government and consumers to hold trial sponsors accountable for their actions.

  1. Development of the SoFAS (solid fats and added sugars) concept: the 2010 Dietary Guidelines for Americans. (United States)

    Nicklas, Theresa A; O'Neil, Carol E


    The diets of most US children and adults are poor, as reflected by low diet quality scores, when compared with the recommendations of the Dietary Guidelines for Americans (DGAs). Contributing to these low scores is that most Americans overconsume solid fats, which may contain saturated fatty acids and added sugars; although alcohol consumption was generally modest, it provided few nutrients. Thus, the 2005 DGAs generated a new recommendation: to reduce intakes of solid fats, alcohol, and added sugars (SoFAAS). What precipitated the emergence of the new SoFAAS terminology was the concept of discretionary calories (a "calorie" is defined as the amount of energy needed to increase the temperature of 1 kg of water by 1°C), which were defined as calories consumed after an individual had met his or her recommended nutrient intakes while consuming fewer calories than the daily recommendation. A limitation with this concept was that additional amounts of nutrient-dense foods consumed beyond the recommended amount were also considered discretionary calories. The rationale for this was that if nutrient-dense foods were consumed beyond recommended amounts, after total energy intake was met then this constituted excess energy intake. In the 2010 DGAs, the terminology was changed to solid fats and added sugars (SoFAS); thus, alcohol was excluded because it made a minor contribution to overall intake and did not apply to children. The SoFAS terminology also negated nutrient-dense foods that were consumed in amounts above the recommendations for the specific food groups in the food patterns. The ambiguous SoFAS terminology was later changed to "empty calories" to reflect only those calories from solid fats and added sugars (and alcohol if consumed beyond moderate amounts). The purpose of this review is to provide an historical perspective on how the dietary recommendations went from SoFAAS to SoFAS and how discretionary calories went to empty calories between the 2005 and 2010

  2. Development of the Advanced Energetic Pair Telescope (AdEPT) for Medium-Energy Gamma-Ray Astronomy (United States)

    Hunter, Stanley D.; Bloser, Peter F.; Dion, Michael P.; McConnell, Mark L.; deNolfo, Georgia A.; Son, Seunghee; Ryan, James M.; Stecker, Floyd W.


    Progress in high-energy gamma-ray science has been dramatic since the launch of INTEGRAL, AGILE and FERMI. These instruments, however, are not optimized for observations in the medium-energy (approx.0.3< E(sub gamma)< approx.200 MeV) regime where many astrophysical objects exhibit unique, transitory behavior, such as spectral breaks, bursts, and flares. We outline some of the major science goals of a medium-energy mission. These science goals are best achieved with a combination of two telescopes, a Compton telescope and a pair telescope, optimized to provide significant improvements in angular resolution and sensitivity. In this paper we describe the design of the Advanced Energetic Pair Telescope (AdEPT) based on the Three-Dimensional Track Imager (3-DTI) detector. This technology achieves excellent, medium-energy sensitivity, angular resolution near the kinematic limit, and gamma-ray polarization sensitivity, by high resolution 3-D electron tracking. We describe the performance of a 30x30x30 cm3 prototype of the AdEPT instrument.

  3. Development of a new connection for precast concrete walls subjected to cyclic loading (United States)

    Vaghei, Ramin; Hejazi, Farzad; Taheri, Hafez; Jaafar, Mohd Saleh; Aziz, Farah Nora Aznieta Abdul


    The Industrialized Building System (IBS) was recently introduced to minimize the time and cost of project construction. Accordingly, ensuring the integration of the connection of precast components in IBS structures is an important factor that ensures stability of buildings subjected to dynamic loads from earthquakes, vehicles, and machineries. However, structural engineers still lack knowledge on the proper connection and detailed joints of IBS structure construction. Therefore, this study proposes a special precast concrete wall-to-wall connection system for dynamic loads that resists multidirectional imposed loads and reduces vibration effects (PI2014701723). This system is designed to connect two adjacent precast wall panels by using two steel U-shaped channels (i.e., male and female joints). During casting, each joint is adapted for incorporation into a respective wall panel after considering the following conditions: one side of the steel channel opens into the thickness face of the panel; a U-shaped rubber is implemented between the two channels to dissipate the vibration effect; and bolts and nuts are used to create an extension between the two U-shaped male and female steel channels. The developed finite element model of the precast wall is subjected to cyclic loads to evaluate the performance of the proposed connection during an imposed dynamic load. Connection performance is then compared with conventional connections based on the energy dissipation, stress, deformation, and concrete damage in the plastic range. The proposed precast connection is capable of exceeding the energy absorption of precast walls subjected to dynamic load, thereby improving its resistance behavior in all principal directions.

  4. Positive youth development programs for adolescents with greater psychosocial needs: subjective outcome evaluation over 3 years. (United States)

    Shek, Daniel T L; Sun, Rachel C F


    This study examined the views of 153,761 students participating in a positive youth development program designed for participants with greater psychosocial needs (the Tier 2 Program) in the context of the Project P.A.T.H.S. in Hong Kong. The program was implemented in the extension phase of the project from 2009/10 to 2011/12 school years. A validated subjective outcome evaluation scale was used to assess the views of the program participants toward the program qualities, implementer qualities, and program effectiveness after completion of the program. Nine datasets were used which were derived from the aggregated reports submitted by social service providers designing the Tier 2 Program. Participants generally held favorable views of program qualities, implementer qualities, as well as program effectiveness of the Tier 2 Program. Some small grade and program differences on subjective outcome evaluation were also found. Both program qualities and implementer qualities were significant predictors of program effectiveness in different grades. Consistent with the findings of the initial phase of the Project P.A.T.H.S., the present study suggests that the Tier 2 Program of the Project P.A.T.H.S. in Hong Kong is perceived favorably by program participants and its perceived effectiveness was high. Significant but small grade and program approach differences on subjective outcome evaluation were found. Both program and implementer qualities were predictive of perceived program effectiveness in different grades. Copyright © 2014 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

  5. Informed consent for inclusion into clinical trials: a serious subject to note in the developing world. (United States)

    Izadi, Morteza; Fazel, Mozhgan; Nasiri-Vanashi, Taha; Saadat, Seyed Hasan; Taheri, Saeed


    Informed consent is a critical issue especially in conducting clinical trials that expose human life to medical or surgical interventions. It necessitates a long and complex process through which the participant is presented with all potential favorable and non-favorable consequences upon getting enrolled in the study. The process of taking informed consent is well-understood in developed countries, with every effort taken to enhance and maintain the autonomy of patients and their right to make an informed choice of whether to participate or not. This may not be the case in the developing world.The information given to patients before the trial might not be properly developed and presented, an issue that can result in serious threat to the decision-making process. On the other hand, investigators should remember that enrolling people into a trial with no potential benefit for themselves cannot be considered ethical. In the current debate, we aim to address the issue of how respectfully and ethically clinical research trials can be done on human subjects and what we can do to enhance the practice in an ethical context. Development of a system through which we could warrant all rights of study participants in all cases around the world seems far from view. However, if we are in doubt about the ethics of a clinical trial, we can ask ourselves: "what would we do, if we were in the same position our patients are in now?"

  6. Dynamic ad hoc networks

    CERN Document Server

    Rashvand, Habib


    Motivated by the exciting new application paradigm of using amalgamated technologies of the Internet and wireless, the next generation communication networks (also called 'ubiquitous', 'complex' and 'unstructured' networking) are changing the way we develop and apply our future systems and services at home and on local, national and global scales. Whatever the interconnection - a WiMAX enabled networked mobile vehicle, MEMS or nanotechnology enabled distributed sensor systems, Vehicular Ad hoc Networking (VANET) or Mobile Ad hoc Networking (MANET) - all can be classified under new networking s

  7. Developing Buoyancy Driven Flow of a Nanofluid in a Vertical Channel Subject to Heat Flux

    Directory of Open Access Journals (Sweden)

    Nirmal C. Sacheti


    Full Text Available The developing natural convective flow of a nanofluid in an infinite vertical channel with impermeable bounding walls has been investigated. It is assumed that the nanofluid is dominated by two specific slip mechanisms and that the channel walls are subject to constant heat flux and isothermal temperature, respectively. The governing nonlinear partial differential equations coupling different transport processes have been solved numerically. The variations of velocity, temperature, and nanoparticles concentration have been discussed in relation to a number of physical parameters. It is seen that the approach to the steady-state profiles of velocity and temperature in the present work is different from the ones reported in a previous study corresponding to isothermal wall conditions.

  8. Some recent developments in the international guidelines on the ethics of research involving human subjects. (United States)

    Levine, R J


    We are in a period of reconsideration and revision of international ethical guidelines for the conduct of biomedical research involving human subjects. The proximate cause of much of this activity is the recent controversy over the ethics of the use of a placebo control in the clinical trials of the short-duration regimen of zidovudine for prevention of perinatal transmission of HIV infection, trials that were carried out in several so-called technologically developing countries. Critics of these trials claimed that they were in violation of Article II.3 of the Declaration of Helsinki, which states: "In any medical study, every patient--including those of a control group, if any--should be assured of the best proven diagnostic and therapeutic method. This does not exclude the use of inert placebo in studies where no proven diagnostic or therapeutic method exists." The critics claimed that since the "best proven ... method" is the 076 regimen, this is what must be provided to members of the control groups. Failure to do so, they asserted, was a serious breach of ethics. In response to this allegation, several major international and national agencies convened multidisciplinary groups to consider the ethics of multinational clinical research. The first thing they realized was that Article II.3 was in error in that it did not reflect contemporary ethical thinking. Moreover, it was routinely violated in research conducted in developed as well as in developing countries. What replaces this standard? The 1993 CIOMS International Ethical Guidelines for Biomedical Research Involving Human Subjects include several criteria for justification of research carried out in developing countries. Most importantly, the research must be responsive to the health needs and priorities of the host country. They also require that any therapeutic products developed in such research must be made "reasonably available" to residents of the host country. A new standard is emerging for

  9. Mechanical Anisotropy Development of a Two-Phase Composite Subject to Large Deformation (United States)

    Dabrowski, M.; Schmid, D. W.; Yu, Podladchikov, Yu,


    Evolution of overall mechanical properties has been demonstrated in large strain deformation experiments. Strain softening is frequently employed in geodynamic simulations. In this paper, we quantify the structural and mechanical evolution of a two-phase composite rock subject to pure and simple shear. An inclusion-host type of geometry is assumed, we focus on the weak inclusion scenario and both materials obey a linear viscous behavior. Finite deformation leads to a shape preferred orientation development that results in an overall mechanical anisotropy. We derive the shape evolution model based on an analytical solution for an isolated elliptical inclusion embedded in an anisotropic host and subject to a uniform far field load. The presence of a strong anisotropy in the host leads to an enhanced inclusion stretching. A differential effective medium type of scheme predicting an overall anisotropic viscosity of a composite consisting of aligned elliptical inclusions is proposed and validated by finite element modeling. A comparison with an existing self-consistent averaging scheme is given and the new scheme is shown to provide an improved estimate of the effective normal and shear viscosity for high inclusion concentrations. The two models are combined into a final set of equations describing evolution of a two-phase rock under a shear. Hardening is predicted in pure shear. In simple shear, the hardening phase is followed by a pronounced softening after a shear strain of one, irrespective of inclusion concentration. Numerical simulations resolving evolution of inclusion-host systems under pure and simple shear demonstrate the high accuracy of our model prediction. The shape evolution model provides a sufficient approximation to the shape preferred orientation developing in an aggregate of interacting inclusions. Both in pure and simple shear, deformation localizes into conjugate trails of inclusions leading to formation of complex sigmoidal inclusion shapes.

  10. Evaluation of Sustainable Development Indicators With Fuzzy TOPSIS Based on Subjective and Objective Weights

    Directory of Open Access Journals (Sweden)

    Nang Idayu Nik Zahari


    Full Text Available ABSTRACT: Sustainable development aims at improving and maintaining the well-being of people and the ecology. However, this paper focuses only on the ecological aspects. The selection of the proper ecological protection determinant plays a very important role in improving the environment of Malaysia. This paper will propose a method from Wang and Lee (2009, and Yong (2006 which applies a fuzzy TOPSIS method -- based on subjective and objective weights – to make the required selection. Four alternatives will be tested which are: prevent pollution (A1, conservation (A2, well-manage (A3, and public awareness (A4. Along with these, four criteria need to be considered: water quality factor (C1, land integrity factor (C2, air quality factor (C3, and biodiversity factor (C4. Finally, a numerical example of ecological protection determinant selection is used to illustrate the proposed method. ABSTRAK: Pembangunan lestari bermatlamat memperbaiki dan mengekalkan kesejahteraan rakyat serta ekologi. Walau bagaimanapun, kertas kajian ini hanya memberi tumpuan kepada aspek-aspek ekologi. Pemilihan penentu perlindungan serta keselamatan bagi aspek ekologi memainkan peranan yang amat penting dalam meningkatkan kualiti alam sekitar di Malaysia. Kertas kajian ini telah menggunakan kaedah Wang dan Lee (2009 dan Yong (2006 yang mengaplikasikan kaedah TOPSIS kabur berdasarkan pemberat subjektif dan objektif. Terdapat empat alternatif yang akan diuji iaitu: pencegahan pencemaran (A1, pemuliharaan (A2, pengurusan yang baik (A3, kesedaran orang awam (A4. Selain itu, terdapat empat kriteria yang perlu dipertimbangkan: faktor kualiti air (C1, faktor kualiti tanah (C2, faktor kualiti udara (C3, faktor kepelbagaian biologi (C4. Kesimpulannya, contoh pengiraan untuk memperoleh penentu pemilihan perlindungan ekologi telah digunakan bagi menunjukkan kaedah yang dicadangkan.KEYWORDS: sustainable development; ecological factors; subjective and objective weight; fuzzy TOPSIS

  11. Breast cancer development in transsexual subjects receiving cross-sex hormone treatment. (United States)

    Gooren, Louis J; van Trotsenburg, Michael A A; Giltay, Erik J; van Diest, Paul J


    Transsexual people receive cross-sex hormones as part of their treatment, potentially inducing hormone-sensitive malignancies. To examine the occurrence of breast cancer in a large cohort of Dutch male and female transsexual persons, also evaluating whether the epidemiology accords with the natal sex or the new sex. Number of people with breast cancer between 1975 and 2011. We researched the occurrence of breast cancer among transsexual persons 18-80 years with an exposure to cross-sex hormones between 5 to >30 years. Our study included 2,307 male-to-female (MtF) transsexual persons undergoing androgen deprivation and estrogen administration (52,370 person-years of exposure), and 795 female-to-male (FtM) subjects receiving testosterone (15,974 total years of exposure). Among MtF individuals one case was encountered, as well as a probable but not proven second case. The estimated rate of 4.1 per 100,000 person-years (95% confidence interval [CI]: 0.8-13.0) was lower than expected if these two cases are regarded as female breast cancer, but within expectations if viewed as male breast cancer. In FtM subjects, who were younger and had shorter exposure to cross-sex hormones compared with the MtF group, one breast cancer case occurred. This translated into a rate of 5.9 per 100,000 person-years (95% CI: 0.5-27.4), again lower than expected for female breast cancer but within expected norms for male breast cancer. The number of people studied and duration of hormone exposure are limited but it would appear that cross-sex hormone administration does not increase the risk of breast cancer development, in either MtF or FtM transsexual individuals. Breast carcinoma incidences in both groups are comparable to male breast cancers. Cross-sex hormone treatment of transsexual subjects does not seem to be associated with an increased risk of malignant breast development. © 2013 International Society for Sexual Medicine.

  12. Agreement and Null Subjects in German L2 Development: New Evidence from Reaction-Time Experiments. (United States)

    Clahsen, Harald; Hong, Upyong


    Reports on reaction time experiments investigating subject-verb agreement and null subjects in 33 Korean learners of German and a control group of 20 German native speakers. Results found that the two phenomena do not covary in the Korean learners, indicating that properties of agreement and null subjects are acquired separately from one another.…

  13. The development of multiple drug use among anabolic-androgenic steroid users: six subjective case reports

    Directory of Open Access Journals (Sweden)

    Nyberg Fred


    Full Text Available Abstract Background The inappropriate use of anabolic androgenic steroids (AAS was originally a problem among athletes but AAS are now often used in nonsport situations and by patients attending regular addiction clinics. The aim of this study was to improve understanding of the development of multiple drug use in patients seeking treatment at an addiction clinic for AAS-related problems. Methods We interviewed six patients (four men and two women with experience of AAS use who were attending an addiction clinic for what they believed were AAS-related problems. The patients were interviewed in-depth about their life stories, with special emphasis on social background, substance use, the development of total drug use and subjective experienced psychological and physical side effects. Results There was significant variation in the development of drug use in relation to social background, onset of drug use, relationship to AAS use and experience of AAS effects. All patients had initially experienced positive effects from AAS but, over time, the negative experiences had outweighed the positive effects. All patients were dedicated to excess training and took AAS in combination with gym training, indicating that the use of these drugs is closely related to this form of training. Use of multiple drugs was common either in parallel with AAS use or serially. Conclusion The study shows the importance of understanding how AAS use can develop either with or without the concomitant use of other drugs of abuse. The use of AAS can, however, progress to the use of other drugs. The study also indicates the importance of obtaining accurate, comprehensive information about the development of AAS use in designing treatment programmes and prevention strategies in this area.


    Directory of Open Access Journals (Sweden)

    D. H. Rif’ati


    Full Text Available In the advanced and modern era, technological sophistication led to learning which initially runs, in which teachers and students meet each other and communicate in the classroom, can be implemented through of information technology. Along with the development of information, where books and teachers who initially as a primary source of learning, are now beginning to experience growth from the internet. Mobile learning defined as mobile devices that are used in the learning process. The wave course is one of subject that must be taken by students of physics education in the third semester. This course emphasizes the concepts of wave were reviewed mathematically and the phenomenon that occurs in everyday life. Mobile learning developed in this study in the form of electronic teaching materials on subjects of waves. The aim of this study was to develop electronic teaching material in the form of mobile learning. The sample of this study is 80 students in the third semester students who are taking waves courses. The results show that mobile learning that has been developed has score 3.8 and included valid criteria. Pada era yang serba maju dan modern, kecanggihan teknologi menyebabkan pembelajaran yang awalnya berjalan satu arah, dimana guru dan siswa saling bertemu dan berkomunikasi di dalam kelas, dapat dilaksanakan melalui bantuan teknologi.informasi. Seiring dengan perkembangan informasi, buku dan guru yang awalnya sebagai sumber belajar utama, saat ini sudah mulai mengalami perkembangan dimana sumber belajar yang berasal dari internet sudah mulai sering dimanfaatkan dalam proses pembelajaran. Mobile larning didefinisikan sebagai perangkat mobile yang dipergunakan dalam proses belajar mengajar. Mata kuliah gelombang sendiri merupakan salah satu mata kuliah yang wajib ditempuh oleh mahasiswa program studi pendidikan fisika semester 3. Mata kuliah ini menekankan pada konsep gelombang yang ditinjau secara matematis dan fenomenanya yang terjadi


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    Nuryake Fajaryati


    Full Text Available This study aims to develop an e-module as a medium of learning for the practice course of Measuring Instruments and Measurement in the Department of Electronics Engineering Education of Yogyakarta State University and to determine the feasibility of the e-module. This study employed a method of research and development. The development process was conducted through four phases by using the model of Lee and Owens which consisted of analysis phase, design phase, developing and implementation phase, as well as evaluation phase.The evaluation was conducted in several stages. Firstly, an alpha test for product validation was conducted by the experts on material and media. After that, a beta test was conducted by testing the product in small group users. The subjects of this study were the students of Electronics Engineering. The instruments used to collect the data were a validation sheet and questionnaires. The results of qualitative data were then modified into quantitative data with a range of 1 to 5, then they were converted with a rating scale to determine the feasibility of the medium. The results showed that based on the alpha test, the medium was in a very high quality. Meanwhile, in the beta test of the instructional aspect, in terms of material and evaluation and the multimedia aspect the e-module was respectively considered feasible and quite feasible. The four indicators namely text, image, animation and video were all generally considered feasible. In terms of usage aspect, the e-module was considered feasible where its two indicators, namely instructions and navigation, were generally regarded as very feasible by all respondents.

  16. Seventy Years of Biochemical Subjects' Development in Pharmacy Curricula: Experience from Serbia. (United States)

    Georgiev, Andrijana Milošević; Krajnović, Dušanka; Manojlović, Jelena; Ignjatović, Svetlana; Majkić Singh, Nada


    The pharmacists played an important role in the development of biochemistry as applied chemistry in Serbia. What is more, the first seven state chemists in Serbia were pharmacists. State chemists performed the chemical-toxicological analysis as well as some medical and biochemical ones. When it comes to the education of medical biochemists as health workers, the period after the beginning of the second half of the twentieth century should be taken into account because that is when the training of pharmaceutical staff of the Faculty of Pharmacy, University of Belgrade, begins on the territory of Serbia. This paper presents the development of medical biochemistry through the development of curriculum, personnel and literature since the foundation of the Faculty of Pharmacy in Serbia until today. The aim of this paper is to present the historical development of biochemistry at the Faculty of Pharmacy, University of Belgrade, through analysis of three indicators: undergraduate and postgraduate education of medical biochemists, teaching literature and professional associations and trade associations. The method of direct data was applied in this paper. Also, desktop analysis was used for analyzing of secondary data, regulations, curricula, documents and bibliographic material. Desktop research was conducted and based on the following sources: Archives of the University of Belgrade-Faculty of Pharmacy, Museum of the History of Pharmacy at the University of Belgrade-Faculty of Pharmacy, the Society of Medical Biochemists of Serbia and the Serbian Chamber of Biochemists. The curricula, the Bologna process of improving education, the expansion of the range of subjects, the number of students, professional literature for teaching biochemistry, as well as professional associations and trade associations are presented through the results.

  17. Insulin resistance is associated with the development of albuminuria in Korean subjects without diabetes. (United States)

    Jang, Cheol Min; Hyun, Young Youl; Lee, Kyu Beck; Kim, Hyang


    Previous studies have shown that insulin resistance is associated with the development of albuminuria. However, most studies are done on a background of diabetes or metabolic syndrome and there is little data from general population. The aim of this study is to define the effect of insulin resistance on the development of albuminuria in healthy individuals without diabetes. We analyzed 60,047 participants without baseline diabetes or chronic kidney disease, who underwent at least two health maintenance visits at a 2-year interval between 2002 and 2009 at a tertiary hospital in Korea. We measured the incidence of albuminuria at the second examination and calculated the odds ratio for the development of albuminuria according to the quintile of the homeostasis model assessment of insulin resistance (HOMA-IR). After 2 years, 880 cases of incident albuminuria were observed. The cumulative incidences of albuminuria were 1.08, 1.50, 1.35, 1.47, and 1.92% for the 1st to 5th quintiles of HOMA-IR. On multivariate logistic analysis, the odds ratios for incident albuminuria compared to those in the 1st quintile were 1.38 (95% CI 1.10-1.73; P=0.006), 1.23 (95% CI 0.97-1.55; P=0.087), 1.32 (95% CI 1.04-1.67; P=0.020), and 1.66 (95% CI 1.31-2.09; Palbuminuria in relatively healthy subjects without diabetes. Further research is needed to verify the role of insulin resistance in the development of albuminuria and renal injury.

  18. Research Project "Subject Developing Environment of Preschool Education" for Russian Preschool Bilinguals (By the Example of Textile Educational Materials) (United States)

    Latipova, Liliya A.; Krapotkina, Irene E.; Koudrjavtseva, Ekaterina L.


    The problem's relevance stated in the article is determined by the following: forming preschool bilinguals' subject developing environment is connected with their active education and development, as well as with flexible preparation for studying at school. The purpose of this article is to develop methodology of textile developing materials' use…

  19. Quadrantal macular retinal thickness changes in strabismus subjects with abnormal binocular vision development. (United States)

    Oka, Mayumi; Yamashita, Tsutomu; Ono, Shizuka; Kubo, Ikumi; Tabuchi, Akio


    To investigate retinal morphological changes in strabismus patients with abnormal binocular vision development by comparing differences in quadrantal macular retinal thickness. Six strabismus patients (6 dominant and 5 non-dominant eyes) with abnormal binocular vision (mean age 22 years), and 11 control subjects (11 dominant and 11 non-dominant eyes) (mean age 21 years) were enrolled. Macular retinal thickness measurements were performed by optical coherence tomography, with total macular retinal (TMR) and ganglion cell complex (GCC) thicknesses measured in 3- and 6-mm regions in each quadrant. Measurement values were then used to determine quadrant ratios. Compared to the dominant eyes of the controls, the superior/inferior (S/I) ratio of the TMR thickness and GCC thickness in the 3-mm region was significantly lower in the dominant eyes of the strabismus group (P binocular vision development exhibited thinner superior temporal GCC thicknesses in the 3-mm region. Retinal ganglion cells in this region might be affected by efferent neural degeneration that originates in the visual pathway responsible for adaptations to the visual experience.

  20. Research and Development on Automatic Information Organization and Subject Analysis in Recent Decades

    Directory of Open Access Journals (Sweden)

    Yuen-Hsien Tseng


    Full Text Available Information organization and subject analysis (IOSA is an important issue in the field of library and information science(LIS.As the fast advance in information technology, more and more digital documents are emerging in a pace such that automated IOSA become inevitable. This article firstly introduces the development of related automatic techniques in recent decades and promotes a tranditional viewpoint based on the workflow of:(1 data collection and aggregation, (2 cataloguing, (3 regulation, (4 archving, and (5 usage,to regulate the whole process when applying automated techniques to any IOSA task.Some application examples are then described to let the readers have a feel of the feasibility of these techniques; specifically the applications of keyword extraction, association analysis, document clustering, and topic categorization are mentioned.We conclude that the related techniques and applications are still developing in a quick pace such that only a few percentages of them can be mentioned.This article is intended to promote the mutual cooperation among the LIS and other fields.

  1. Chemical Composition of Date-Pits and Its Potential for Developing Value-Added Product - a Review

    Directory of Open Access Journals (Sweden)

    Hossain Mohammad Zakir


    Full Text Available Moisture, protein, oil and carbohydrate contents of date-pits varied from 3.1-12.5, 2.3-6.9, 5.0-12.5 and 70.9-86.9 g/100 g date-pits, respectively. BET-monolayer (i.e. strongly bound moisture content, solids-melting peak (at moisture: 6.7 g/100 g date-pits, and melting point of oil were 4.3 g/100 g dry-solids, 106oC, and 1.8oC, respectively. The major fatty acids were lauric, myristic, palmitic, stearic, oleic, and linoleic acids and polyphenol content varied from 21.0-62.0 mg/g date-pits depending on the varieties, types of solvent and temperature used for extraction. Date-pits showed effectives in animal and poultry feeds and it could be used as value added products, such as: dietary fibres, functional polysaccharides, caffeine-free drinks (similar to coffee, oil (biofuel or cooking oil, and other functional or medicinal products. Date-pits powder and activated carbon from date–pits showed effective in purifying water by removing different types of pollutants, such as heavy metals, boron, dyes, phenolic compounds, and pesticides. Date-pits also showed effective to be used as ingredient for composed, biomass, and fermentation processes.

  2. The Predictors of Subjective Career Success: An Empirical Study of Employee Development in a Korean Financial Company (United States)

    Park, Yongho


    Subjective career success has recently been discussed widely in the academic field of career development. The purpose of this study was to investigate the predictors of subjective career success. It examined the effects of the calling work orientation, the individual's career-enhancing strategy and the organizational learning climate on the…

  3. Axion wormholes in AdS compactifications (United States)

    Hertog, Thomas; Trigiante, Mario; Van Riet, Thomas


    We find regular axionic Euclidean wormhole solutions in Type IIB string theory compactified on {AdS}_5× {S}^5/{Z}_k . AdS/CFT enables a precise derivation of the axion content of the Euclidean theory, placing the string theory embedding of the wormholes on firm footing. This further sharpens the paradox posed by these solutions.

  4. Factors associated with developing a fear of falling in subjects with primary open-angle glaucoma. (United States)

    Adachi, Sayaka; Yuki, Kenya; Awano-Tanabe, Sachiko; Ono, Takeshi; Shiba, Daisuke; Murata, Hiroshi; Asaoka, Ryo; Tsubota, Kazuo


    To investigate the relationship between clinical risk factors, including visual field (VF) defects and visual acuity, and a fear of falling, among patients with primary open-angle glaucoma (POAG). All participants answered the following question at a baseline ophthalmic examination: Are you afraid of falling? The same question was then answered every 12 months for 3 years. A binocular integrated visual field was calculated by merging a patient's monocular Humphrey field analyzer VFs, using the 'best sensitivity' method. The means of total deviation values in the whole, superior peripheral, superior central, inferior central, and inferior peripheral VFs were calculated. The relationship between these mean VF measurements, and various clinical factors, against patients' baseline fear of falling and future fear of falling was analyzed using multiple logistic regression. Among 392 POAG subjects, 342 patients (87.2%) responded to the fear of falling question at least twice in the 3 years study period. The optimal regression model for patients' baseline fear of falling included age, gender, mean of total deviation values in the inferior peripheral VF and number of previous falls. The optimal regression equation for future fear of falling included age, gender, mean of total deviation values in the inferior peripheral VF and number of previous falls. Defects in the inferior peripheral VF area are significantly related to the development of a fear of falling.

  5. Library Subject Guides: A Case Study of Evidence-Informed Library Development (United States)

    Wakeham, Maurice; Roberts, Angharad; Shelley, Jane; Wells, Paul


    This paper describes the process whereby a university library investigated the value of its subject guides to its users. A literature review and surveys of library staff, library users and other libraries were carried out. Existing library subject guides and those of other higher education libraries were evaluated. The project team reported…

  6. Brief assessment of subjective health complaints: Development, validation and population norms of a brief form of the Giessen Subjective Complaints List (GBB-8). (United States)

    Kliem, Sören; Lohmann, Anna; Klatt, Thimna; Mößle, Thomas; Rehbein, Florian; Hinz, Andreas; Beutel, Manfred; Brähler, Elmar


    Although there is no causal relationship to medical morbidity, routine clinical assessment of somatic symptoms aids medical diagnosis and assessment of treatment effectiveness. Regardless of their causes, somatic symptoms indicate suffering, distress, and help-seeking behavior. The aim of the present study was to develop and validate a brief self-report questionnaire to assess somatic symptom strain. A brief form of the Giessen Subjective Complaints List (GBB-8) was developed and validated in a large population sample representative of the Federal Republic of Germany (N=2008). Psychometric analyses included confirmation of factor structure, classical item analysis, and measurement invariance tests. The sample furthermore served as a norm group. As indicators of construct validity, correlations with measures of anxiety, depression, alexithymia, and primary care contact were computed. Psychometric analyses yielded excellent scale properties regarding item characteristics, factor structure, and measurement invariance tests (Cronbach's alpha=0.88; CFI=0.980, TLI=0.965, RMSEA=0.049) for the second-order four-factor model; strict invariance was confirmed for gender, depression status, and physician contacts; strong invariance was confirmed regarding age and age×gender. The GBB-8 with its four subscales exhaustion, gastrointestinal complaints, musculoskeletal complaints, and cardiovascular complaints proves to be an economic measure of subjective symptom strain. Psychometric analyses deem it suitable for epidemiological research. The availability of norms makes it a potential everyday tool for general practitioners and psychosomatic clinics. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Proposal for the risk management implementation phase in oil field development project by adding value on the refurbishment of critical equipment

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    Hamid Abdul


    Full Text Available Refurbishment process is a conceptual stage in product life cycle. It is utilized in existing equipment in the field by adding value to recondition and repaired equipment. The main interest of this paper is to implement and design risk management implementation phase in oil field development project on the refurbishment of critical equipment in oil and gas industry. This paper is provided base on research and experiences in risk management and learned from practical team in industry which matched by an application in oil field development project in refurbishment of critical equipment. A framework of implementation phase for risk management in oil field development project in refurbishment critical equipment were reviewed and added value on communication skills of the project team to the stakeholder and organization, which support to external body and vice-versa. Risk management framework can be used for reference of refurbishment process with simply process and developed with same concept for the next wide development project in industry.

  8. Polarised Black Holes in AdS

    CERN Document Server

    Costa, Miguel S.; Oliveira, Miguel; Penedones, João; Santos, Jorge E.


    We consider solutions in Einstein-Maxwell theory with a negative cosmological constant that asymptote to global $AdS_{4}$ with conformal boundary $S^{2}\\times\\mathbb{R}_{t}$. At the sphere at infinity we turn on a space-dependent electrostatic potential, which does not destroy the asymptotic $AdS$ behaviour. For simplicity we focus on the case of a dipolar electrostatic potential. We find two new geometries: (i) an $AdS$ soliton that includes the full backreaction of the electric field on the $AdS$ geometry; (ii) a polarised neutral black hole that is deformed by the electric field, accumulating opposite charges in each hemisphere. For both geometries we study boundary data such as the charge density and the stress tensor. For the black hole we also study the horizon charge density and area, and further verify a Smarr formula. Then we consider this system at finite temperature and compute the Gibbs free energy for both $AdS$ soliton and black hole phases. The corresponding phase diagram generalizes the Hawkin...

  9. Data Base Development of Automobile and Light Truck Maintenance : Volume I. Test and Appendixes A-D (United States)


    The volume describes the development of the life cycle maintenance costs for 212 sales-leading 1970 through 1975 passenger cars and light trucks. These costs provide a data base for the Department of Transportation, which describes the costs for part...

  10. Evaluating the Value-Added Impact of Outdoor Management Training for Leadership Development in an MBA Program (United States)

    Kass, Darrin; Grandzol, Christian


    This study examined the benefits of Outdoor Management Training for the leadership development of students enrolled in an MBA-level Organizational Behavior course. Students enrolled in one of two experiential courses. Both were identical, except one included an intensive outdoor training component called Leadership on the Edge. The…

  11. Expanding subjectivities

    DEFF Research Database (Denmark)

    Lundgaard Andersen, Linda; Soldz, Stephen


    A major theme in recent psychoanalytic thinking concerns the use of therapist subjectivity, especially “countertransference,” in understanding patients. This thinking converges with and expands developments in qualitative research regarding the use of researcher subjectivity as a tool to understa...

  12. Rhetorical meta-language to promote the development of students' writing skills and subject matter understanding (United States)

    Pelger, Susanne; Sigrell, Anders


    Background: Feedback is one of the most significant factors for students' development of writing skills. For feedback to be successful, however, students and teachers need a common language - a meta-language - for discussing texts. Not least because in science education such a meta-language might contribute to improve writing training and feedback-giving. Purpose: The aim of this study was to explore students' perception of teachers' feedback given on their texts in two genres, and to suggest how writing training and feedback-giving could become more efficient. Sample: In this study were included 44 degree project students in biology and molecular biology, and 21 supervising teachers at a Swedish university. Design and methods: The study concerned students' writing about their degree projects in two genres: scientific writing and popular science writing. The data consisted of documented teacher feedback on the students' popular science texts. It also included students' and teachers' answers to questionnaires about writing and feedback. All data were collected during the spring of 2012. Teachers' feedback, actual and recalled - by students and teachers, respectively - was analysed and compared using the so-called Canons of rhetoric. Results: While the teachers recalled the given feedback as mainly positive, most students recalled only negative feedback. According to the teachers, suggested improvements concerned firstly the content, and secondly the structure of the text. In contrast, the students mentioned language style first, followed by content. Conclusions: The disagreement between students and teachers regarding how and what feedback was given on the students texts confirm the need of improved strategies for writing training and feedback-giving in science education. We suggest that the rhetorical meta-language might play a crucial role in overcoming the difficulties observed in this study. We also discuss how training of writing skills may contribute to

  13. Developing crash modification functions to assess safety effects of adding bike lanes for urban arterials with different roadway and socio-economic characteristics. (United States)

    Park, Juneyoung; Abdel-Aty, Mohamed; Lee, Jaeyoung; Lee, Chris


    Although many researchers have estimated crash modification factors (CMFs) for specific treatments (or countermeasures), there is a lack of studies that explored the heterogeneous effects of roadway characteristics on crash frequency among treated sites. Generally, the CMF estimated by before-after studies represents overall safety effects of the treatment in a fixed value. However, as each treated site has different roadway characteristics, there is a need to assess the variation of CMFs among the treated sites with different roadway characteristics through crash modification functions (CMFunctions). The main objective of this research is to determine relationships between the safety effects of adding a bike lane and the roadway characteristics through (1) evaluation of CMFs for adding a bike lane using observational before-after with empirical Bayes (EB) and cross-sectional methods, and (2) development of simple and full CMFunctions which are describe the CMF in a function of roadway characteristics of the sites. Data was collected for urban arterials in Florida, and the Florida-specific full SPFs were developed. Moreover, socio-economic parameters were collected and included in CMFunctions and SPFs (1) to capture the effects of the variables that represent volume of bicyclists and (2) to identify general relationship between the CMFs and these characteristics. In order to achieve better performance of CMFunctions, data mining techniques were used. The results of both before-after and cross-sectional methods show that adding a bike lane on urban arterials has positive safety effects (i.e., CMFbike crashes. It was found that adding a bike lane is more effective in reducing bike crashes than all crashes. It was also found that the CMFs vary across the sites with different roadway characteristics. In particular, annual average daily traffic (AADT), number of lanes, AADT per lane, median width, bike lane width, and lane width are significant characteristics that


    Directory of Open Access Journals (Sweden)

    Nina Ivanovna Lygina


    Full Text Available In this paper we will present the results of a pedagogical experiment aimed at studying the level of social skills in university professors. Planning cross subject communications in an academic subject with consideration of the previous and associated knowledge and skills of students in the educational programme formed the basis of the pedagogical experiment. Problems have occurred when university professors are faced with elaborating cross subject communications. It was discovered that the problems professors had were connected to their responsiveness and to the various strategies they applied while working within small groups. We will analyze the results, provide recommendations and show the change in the level of the professors’ social skills during elaboration of  cross subject communications.DOI:

  15. Adding requirements on customers to current quality models toimprove quality : development of a customer ‐ vendor interaction


    Abrahamsson, Sten; Isaksson, Raine


    In most descriptions of business development and models for Corporate Governance, contacts between supplier and customer are for the most part focused on the supplier’s responsibility to identify and document customer requirements in order to enable the organization to meet customer requirements (stated and unstated). In the actual contact between customer and supplier it has been observed in several cases that there are aspects of the interaction not described in traditional theoretical qual...

  16. Adding sound to theory of mind: Comparing children's development of mental-state understanding in the auditory and visual realms. (United States)

    Hasni, Anita A; Adamson, Lauren B; Williamson, Rebecca A; Robins, Diana L


    Theory of mind (ToM) gradually develops during the preschool years. Measures of ToM usually target visual experience, but auditory experiences also provide valuable social information. Given differences between the visual and auditory modalities (e.g., sights persist, sounds fade) and the important role environmental input plays in social-cognitive development, we asked whether modality might influence the progression of ToM development. The current study expands Wellman and Liu's ToM scale (2004) by testing 66 preschoolers using five standard visual ToM tasks and five newly crafted auditory ToM tasks. Age and gender effects were found, with 4- and 5-year-olds demonstrating greater ToM abilities than 3-year-olds and girls passing more tasks than boys; there was no significant effect of modality. Both visual and auditory tasks formed a scalable set. These results indicate that there is considerable consistency in when children are able to use visual and auditory inputs to reason about various aspects of others' mental states. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Development of realistic physical breast phantoms matched to virtual breast phantoms based on human subject data. (United States)

    Kiarashi, Nooshin; Nolte, Adam C; Sturgeon, Gregory M; Segars, William P; Ghate, Sujata V; Nolte, Loren W; Samei, Ehsan; Lo, Joseph Y


    Physical phantoms are essential for the development, optimization, and evaluation of x-ray breast imaging systems. Recognizing the major effect of anatomy on image quality and clinical performance, such phantoms should ideally reflect the three-dimensional structure of the human breast. Currently, there is no commercially available three-dimensional physical breast phantom that is anthropomorphic. The authors present the development of a new suite of physical breast phantoms based on human data. The phantoms were designed to match the extended cardiac-torso virtual breast phantoms that were based on dedicated breast computed tomography images of human subjects. The phantoms were fabricated by high-resolution multimaterial additive manufacturing (3D printing) technology. The glandular equivalency of the photopolymer materials was measured relative to breast tissue-equivalent plastic materials. Based on the current state-of-the-art in the technology and available materials, two variations were fabricated. The first was a dual-material phantom, the Doublet. Fibroglandular tissue and skin were represented by the most radiographically dense material available; adipose tissue was represented by the least radiographically dense material. The second variation, the Singlet, was fabricated with a single material to represent fibroglandular tissue and skin. It was subsequently filled with adipose-equivalent materials including oil, beeswax, and permanent urethane-based polymer. Simulated microcalcification clusters were further included in the phantoms via crushed eggshells. The phantoms were imaged and characterized visually and quantitatively. The mammographic projections and tomosynthesis reconstructed images of the fabricated phantoms yielded realistic breast background. The mammograms of the phantoms demonstrated close correlation with simulated mammographic projection images of the corresponding virtual phantoms. Furthermore, power-law descriptions of the phantom images

  18. Development of realistic physical breast phantoms matched to virtual breast phantoms based on human subject data

    Energy Technology Data Exchange (ETDEWEB)

    Kiarashi, Nooshin [Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710 and Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina 27708 (United States); Nolte, Adam C. [Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710 and Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708 (United States); Sturgeon, Gregory M.; Ghate, Sujata V. [Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710 (United States); Segars, William P. [Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710 and Medical Physics Graduate Program, Duke University, Durham, North Carolina 27708 (United States); Nolte, Loren W. [Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina 27708 and Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708 (United States); Samei, Ehsan [Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710 (United States); Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina 27708 (United States); Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708 (United States); Medical Physics Graduate Program, Duke University, Durham, North Carolina 27708 (United States); Department of Physics, Duke University, Durham, North Carolina 27708 (United States); and others


    Purpose: Physical phantoms are essential for the development, optimization, and evaluation of x-ray breast imaging systems. Recognizing the major effect of anatomy on image quality and clinical performance, such phantoms should ideally reflect the three-dimensional structure of the human breast. Currently, there is no commercially available three-dimensional physical breast phantom that is anthropomorphic. The authors present the development of a new suite of physical breast phantoms based on human data. Methods: The phantoms were designed to match the extended cardiac-torso virtual breast phantoms that were based on dedicated breast computed tomography images of human subjects. The phantoms were fabricated by high-resolution multimaterial additive manufacturing (3D printing) technology. The glandular equivalency of the photopolymer materials was measured relative to breast tissue-equivalent plastic materials. Based on the current state-of-the-art in the technology and available materials, two variations were fabricated. The first was a dual-material phantom, the Doublet. Fibroglandular tissue and skin were represented by the most radiographically dense material available; adipose tissue was represented by the least radiographically dense material. The second variation, the Singlet, was fabricated with a single material to represent fibroglandular tissue and skin. It was subsequently filled with adipose-equivalent materials including oil, beeswax, and permanent urethane-based polymer. Simulated microcalcification clusters were further included in the phantoms via crushed eggshells. The phantoms were imaged and characterized visually and quantitatively. Results: The mammographic projections and tomosynthesis reconstructed images of the fabricated phantoms yielded realistic breast background. The mammograms of the phantoms demonstrated close correlation with simulated mammographic projection images of the corresponding virtual phantoms. Furthermore, power

  19. Development of an intelligent interface for adding spatial objects to a knowledge-based geographic information system (United States)

    Campbell, William J.; Goettsche, Craig


    Earth Scientists lack adequate tools for quantifying complex relationships between existing data layers and studying and modeling the dynamic interactions of these data layers. There is a need for an earth systems tool to manipulate multi-layered, heterogeneous data sets that are spatially indexed, such as sensor imagery and maps, easily and intelligently in a single system. The system can access and manipulate data from multiple sensor sources, maps, and from a learned object hierarchy using an advanced knowledge-based geographical information system. A prototype Knowledge-Based Geographic Information System (KBGIS) was recently constructed. Many of the system internals are well developed, but the system lacks an adequate user interface. A methodology is described for developing an intelligent user interface and extending KBGIS to interconnect with existing NASA systems, such as imagery from the Land Analysis System (LAS), atmospheric data in Common Data Format (CDF), and visualization of complex data with the National Space Science Data Center Graphics System. This would allow NASA to quickly explore the utility of such a system, given the ability to transfer data in and out of KBGIS easily. The use and maintenance of the object hierarchies as polymorphic data types brings, to data management, a while new set of problems and issues, few of which have been explored above the prototype level.

  20. Development and validation of a biomarker for diarrhea-predominant irritable bowel syndrome in human subjects.

    Directory of Open Access Journals (Sweden)

    Mark Pimentel

    Full Text Available Diarrhea-predominant irritable bowel syndrome (IBS is diagnosed through clinical criteria after excluding "organic" conditions, and can be precipitated by acute gastroenteritis. Cytolethal distending toxin B (CdtB is produced by bacteria that cause acute gastroenteritis, and a post-infectious animal model demonstrates that host antibodies to CdtB cross-react with vinculin in the host gut, producing an IBS-like phenotype. Therefore, we assessed circulating anti-CdtB and anti-vinculin antibodies as biomarkers for D-IBS in human subjects. Subjects with D-IBS based on Rome criteria (n=2375 were recruited from a large-scale multicenter clinical trial for D-IBS (TARGET 3. Subjects with inflammatory bowel disease (IBD (n=142, subjects with celiac disease (n=121, and healthy controls (n=43 were obtained for comparison. Subjects with IBD and celiac disease were recruited based on the presence of intestinal complaints and histologic confirmation of chronic inflammatory changes in the colon or small intestine. Subjects with celiac disease were also required to have an elevated tTG and biopsy. All subjects were aged between 18 and 65 years. Plasma levels of anti-CdtB and anti-vinculin antibodies were determined by ELISA, and compared between groups. Anti-CdtB titers were significantly higher in D-IBS subjects compared to IBD, healthy controls and celiac disease (P<0.001. Anti-vinculin titers were also significantly higher in IBS (P<0.001 compared to the other groups. The area-under-the-receiver operating curves (AUCs were 0.81 and 0.62 for diagnosis of D-IBS against IBD for anti-CdtB and anti-vinculin, respectively. Both tests were less specific in differentiating IBS from celiac disease. Optimization demonstrated that for anti-CdtB (optical density≥2.80 the specificity, sensitivity and likelihood ratio were 91.6%, 43.7 and 5.2, respectively, and for anti-vinculin (OD≥1.68 were 83.8%, 32.6 and 2.0, respectively. These results confirm that anti-CdtB and

  1. Development and validation of a biomarker for diarrhea-predominant irritable bowel syndrome in human subjects. (United States)

    Pimentel, Mark; Morales, Walter; Rezaie, Ali; Marsh, Emily; Lembo, Anthony; Mirocha, James; Leffler, Daniel A; Marsh, Zachary; Weitsman, Stacy; Chua, Kathleen S; Barlow, Gillian M; Bortey, Enoch; Forbes, William; Yu, Allen; Chang, Christopher


    Diarrhea-predominant irritable bowel syndrome (IBS) is diagnosed through clinical criteria after excluding "organic" conditions, and can be precipitated by acute gastroenteritis. Cytolethal distending toxin B (CdtB) is produced by bacteria that cause acute gastroenteritis, and a post-infectious animal model demonstrates that host antibodies to CdtB cross-react with vinculin in the host gut, producing an IBS-like phenotype. Therefore, we assessed circulating anti-CdtB and anti-vinculin antibodies as biomarkers for D-IBS in human subjects. Subjects with D-IBS based on Rome criteria (n=2375) were recruited from a large-scale multicenter clinical trial for D-IBS (TARGET 3). Subjects with inflammatory bowel disease (IBD) (n=142), subjects with celiac disease (n=121), and healthy controls (n=43) were obtained for comparison. Subjects with IBD and celiac disease were recruited based on the presence of intestinal complaints and histologic confirmation of chronic inflammatory changes in the colon or small intestine. Subjects with celiac disease were also required to have an elevated tTG and biopsy. All subjects were aged between 18 and 65 years. Plasma levels of anti-CdtB and anti-vinculin antibodies were determined by ELISA, and compared between groups. Anti-CdtB titers were significantly higher in D-IBS subjects compared to IBD, healthy controls and celiac disease (PIBS (PIBS against IBD for anti-CdtB and anti-vinculin, respectively. Both tests were less specific in differentiating IBS from celiac disease. Optimization demonstrated that for anti-CdtB (optical density≥2.80) the specificity, sensitivity and likelihood ratio were 91.6%, 43.7 and 5.2, respectively, and for anti-vinculin (OD≥1.68) were 83.8%, 32.6 and 2.0, respectively. These results confirm that anti-CdtB and anti-vinculin antibodies are elevated in D-IBS compared to non-IBS subjects. These biomarkers may be especially helpful in distinguishing D-IBS from IBD in the workup of chronic diarrhea.

  2. Recent developments in single-subject methodology: methods for analyzing generalization, maintenance, and multicomponent treatments. (United States)

    Barrios, B A; Hartmann, D P


    At the outset of this chapter we asked whether or not single-subject methodology has outlived its usefulness to behavior therapy. We did so because serious doubts have been expressed about the ability of single-subject methodology to address the salient issues of the day. This chapter allays many of these doubts. This chapter reveals that single-subject researchers are far from helpless when investigating generalization and maintenance and identifying the active (and inactive) components in their compound treatments. In fact, a number of powerful strategies are at their disposal--strategies that are not strangers to the armamentarium of single-case researchers. These strategies are in essence nothing more than extensions of the reversal, multiple baseline, and simultaneous and alternating-treatments designs. In the case of the assessment of generalization, these extensions involve little more than the inclusion of continuous measures (or regular probes) of untrained responses throughout the investigation. In the case of the assessment of maintenance, they involve the replacement of a comparison of two or more acquisition procedures with a comparison of two or more maintenance procedures. And in the case of the identification of active (and inactive) components of compound treatments, they involve the aggregation of the findings from a series of single-subject investigations. When the requirements of single-subject designs and their extensions cannot be met, investigators still have available a set of traditional group designs (e.g., factorial and additive designs) for attacking these same issues. Assessment of generalization, maintenance, and the components of compound treatments are not the only salient issues facing behavior therapy today. Another is the widening gap between the researcher and the practitioner (e.g., Barlow, 1980; Wilson, 1981). It is thought by some that single-subject methodology may be the means of bridging this gap; that through single-subject

  3. Using Portfolios to Engage Introductory Geoscience Students in Their Subject and to Develop Learning Skills. (United States)

    Boyle, A. P.; Prior, D. J.


    It is often difficult to deal with wide-ranging, exciting geoscience topics at introductory level when the background geoscience knowledge of the incoming students is limited. This means that new students can often be confronted by self-contained, subject-based topics (e.g. introductory mineralogy) and fail to see where the bigger pictures may be. Another issue, partly arising from massification and thus increasing diversity of student cohorts but also to changes in UK school education goals, is the realisation that incoming students have difficulties combining lecture note taking, reading and general organisation of paper-based materials into a learning package that can help them write structured essays. They need help with the transfer from school to university education. Two years ago, a curriculum review provided the opportunity to develop a new module that could address these issues. The module deals with current topics. Students attend a series of 8 lectures given by 8 different faculty staff covering topics like The Origin of the Moon, Earthquake Prediction, Mass Extinctions, Snowball Earth, and Geohazards spread over the introductory year. Each lecturer uses whatever delivery style they want (PowerPoint, chalk and talk), but the lecture must be an illustration of the scientific method dealing with evidence, models and uncertainty, and must direct students towards a range of associated reading. The students develop a portfolio with a section for each lecture topic. Each section contains their notes, annotated copies of the reading and a one page (A4) summary of the main points of the topic, derived from both the notes and reading. The students also develop a glossary of geological terms. In addition, the students must attend 6 extra talks given by guest speakers at either the student society meetings or the departmental seminar series. Assessment is by the portfolio (40%) and a final essay paper (60%). The portfolio is collected in at the end of the first

  4. Imbalances of innovative industrial development of subjects of Federation, members of the Russian Arctic zone

    Directory of Open Access Journals (Sweden)

    Zharov V. S.


    Full Text Available The results of testing the previously developed methodological approach and methods of assessing the innovativeness level of the industrial development of the regions – subjects of the Federation (members of the Russian Arctic zone – on the basis of the calculation and analysis of scorecard values have been presented. It has been shown that during the years 2005–2013, the highest level of technological innovation of industrial development had been achieved in the Republic of Sakha (Yakutia. Представлены результаты апробации разработанных ранее методологического подхода и методики оценки уровня инновационности промышленного развития регионов – субъектов Федерации, входящих в Арктическую зону РФ, – на основе расчета и анализа значений системы показателей. Показано, что в течение 2005–2013 гг. наиболее высокий уровень технологической инновационности промышленного развития достигнут в Республике Саха (Якутия

  5. Developing an integrated biomedical and behavioural theory of functioning and disability: adding models of behaviour to the ICF framework. (United States)

    Johnston, Marie; Dixon, Diane


    The International Classification of Functioning Disability and Health (ICF) offers an agreed language on which a scientific model of functional outcomes can be built. The ICF defines functional outcomes as activity and activity limitations (AL) and defines both in behavioural terms. The ICF, therefore, appears to invite explanations of AL as behaviours. Studies of AL find that psychological variables, especially perceptions of control, add to biomedical variables in predicting AL. Therefore, two improved models are proposed, which integrate the ICF with two psychological theories, the theory of planned behaviour (TPB) and social cognitive theory (SCT). These models have a sound evidence base as good predictors of behaviour, include perceived control constructs and are compatible with existing evidence about AL. When directly tested in studies of community and clinic-based populations, both integrated models (ICF/TPB and ICF/SCT) outperform each of the three basic models (ICF, TPB and SCT). However, when predicting activity rather than AL, the biomedical model of the ICF does not improve prediction of activity by TPB and SCT on their own. It is concluded that these models offer a better explanation of functional outcomes than the ICF alone and could form the basis for the development of improved models.

  6. AdS braneworld with Backreaction

    CERN Document Server

    Bilic, Neven


    We review the tachyon model derived from the dynamics of a 3-brane moving in the AdS5 bulk. The bulk geometry is based on the Randall-Sundrum II model extended to include the radion. The effective tachyon Lagrangian is modified due to the back-reaction of the brane on the bulk geometry.

  7. Philosophia ad bellum

    Directory of Open Access Journals (Sweden)

    Yu. O. Loboda


    Full Text Available In the paper «Philosophia ad bellum» is being realized an attempt to classify philosophic approaches to the study of phenomenon of war by the analogy with the structure of «Just war theory» – 1. Philosophia ad bellum – «philosophy for war», where are investigated ways of using of philosophic methods of cognition in applied military sciences; 2. Philosophia supra bello – «philosophy above war», which investigates world­view, historic­philosophic, existential, logic­epistemological aspects of war; 3. Philosophia contra belli – «philosophy against war», where research of the essence of war gets its logical conclusion in grounding of the absurdity of thinking schemes which justify war as an act of violence. In the article was made historic­philosophic overview of the part «Philosophia ad bellum», where were showed tangent questions, which are considered by philosophic logic and theory of strategic intelligence. It was stated, that specialists if military intelligence admit the important role of researches in logic and theory of cognition in their professional work; were defined basic questions, which have the most essential interest for military professionals. There were analyzed ways of using of philosophic methods in developing military strategies, was made a conclusion that philosophy can be a basis of strategic failures and victories as well.

  8. Developing strategies to be added to the protocol for antenatal care: An exercise and birth preparation program

    Directory of Open Access Journals (Sweden)

    Maria Amélia Miquelutti


    Full Text Available OBJECTIVES: To describe the implementation process of a birth preparation program, the activities in the protocol for physical and birth preparation exercises, and the educational activities that have been evaluated regarding effectiveness and women's satisfaction. The birth preparation program described was developed with the following objectives: to prevent lumbopelvic pain, urinary incontinence and anxiety; to encourage the practice of physical activity during pregnancy and of positions and exercises for non-pharmacological pain relief during labor; and to discuss information that would help women to have autonomy during labor. METHODS: The program comprised the following activities: supervised physical exercise, relaxation exercises, and educational activities (explanations of lumbopelvic pain prevention, pelvic floor function, labor and delivery, and which non-pharmacological pain relief to use during labor provided regularly after prenatal consultations. These activities were held monthly, starting when the women joined the program at 18–24 weeks of pregnancy and continuing until 30 weeks of pregnancy, fortnightly thereafter from 31 to 36 weeks of pregnancy, and then weekly from the 37th week until delivery. Information and printed materials regarding the physical exercises to be performed at home were provided. NCT01155804. RESULTS: The program was an innovative type of intervention that systematized birth preparation activities that were organized to encompass aspects related both to pregnancy and to labor and that included physical, educational and home-based activities. CONCLUSIONS: The detailed description of the protocol used may serve as a basis for further studies and also for the implementation of birth preparation programs within the healthcare system in different settings.

  9. Adding silver to the rainbow: the development of the nurses' health education about LGBT elders (HEALE) cultural competency curriculum. (United States)

    Hardacker, Cecilia T; Rubinstein, Betsy; Hotton, Anna; Houlberg, Magda


    In 2009, the Howard Brown Health Center received funding from the US Department of Health and Human Services, and Health Resources and Services Administration to develop and disseminate a peer-reviewed, six-module curriculum entitled, Health Education about LGBT (lesbian, gay, bisexual and transgender) Elders (HEALE). The HEALE curriculum targets nurses and health-care staff and is focused on the treatment of LGBT elders, a population that is largely misunderstood and discriminated against in health-care settings. The HEALE curriculum was presented in hospital academic centres, community-based clinics and nursing homes over a three-year period, and training staff provided education to over 500 nurses and health-care providers. A pre-test and post-test was administered to participants, and all data were collected and archived to measure knowledge gained. Participants also completed an evaluation at the conclusion of the training to report change in personal attitude and individual response to the curriculum. From March 2011 to June 2012, 848 individuals attended HEALE curriculum sessions at 23 locations in Chicago and surrounding areas. Participants were 40% white, 25% black, 9% Hispanic/Latino and 25% Asian race/ethnicity. The majority of participants were female and approximately 25% were under the age of 30 years. There were statistically significant gains in knowledge in each of the six modules both in nursing home/home health-care settings and in hospital/educational settings, although participants in nursing home/home health care settings had lower pre-test scores and smaller knowledge gains in each of the six modules than those in hospital/educational settings. Mean increases ranged from 6.4 points (an 8.7% increase) in module 1-14.6 points (a 26.2% increase) in Module 6 (P LGBT cultural competency in geriatric education. As such, implementation of this cultural competency training will go a long way to establish fundamental concepts regarding LGBT elder care

  10. Learning and the development of social identities in the subjects Care and Technology

    NARCIS (Netherlands)

    Volman, M.L.L.; ten Dam, G.


    This article discusses the way in which social identities structure the learning processes of students in two subjects in the Dutch secondary school curriculum - Care and Technology. It analyses interviews with 23 students and their teachers with a view to explaining the disappointing results in

  11. Learning and the development of social identities in the subjects: Care and Technology

    NARCIS (Netherlands)

    Volman, M.L.L.; ten Dam, G.T.M.


    This article discusses the way in which social identities structure the learning processes of students in two subjects in the Dutch secondary school curriculum - Care and Technology. It analyzes interviews with 23 students and their teachers with a view to explaining the disappointing results in

  12. Developing Multimedia Enhanced Content to Upgrade Subject Content Knowledge of Secondary School Teachers in Tanzania (United States)

    Mtebe, Joel S.; Kibga, Elia Y.; Mwambela, Alfred A.; Kissaka, Mussa M.


    The failure rates and lack of interest amongst students in science and mathematics in secondary schools in Tanzania is a serious problem. The Ministry of Education and Vocational Training (MoEVT) implemented a project to enhance and upgrade the pedagogical knowledge and subject content knowledge of teachers in selected difficult topics in science…

  13. The Role of Subjectivity in Teacher Expertise Development: Mindfully Embracing the "Black Sheep" of Educational Research (United States)

    Inoue, Noriyuki


    In Western cultures, subjectivity has often been seen as the "black sheep" of educational research because of its heavy emphasis on objectivity. Consequently many research initiatives in education share the assumption that objective reasoning should play a central role. However, mentoring teachers' practice improvement research often…

  14. Drag cancellation by added-mass pumping

    CERN Document Server

    Giorgio-Serchi, F


    A submerged body subject to a sudden shape-change experiences large forces due to the variation of added-mass energy. While this phenomenon has been studied for single actuation events, application to sustained propulsion requires studying \\textit{periodic} shape-change. We do so in this work by investigating a spring-mass oscillator submerged in quiescent fluid subject to periodic changes in its volume. We develop an analytical model to investigate the relationship between added-mass variation and viscous damping and demonstrate its range of application with fully coupled fluid-solid Navier-Stokes simulations at large Stokes number. Our results demonstrate that the recovery of added-mass kinetic energy can be used to completely cancel the viscous damping of the fluid, driving the onset of sustained oscillations with amplitudes as large as four times the average body radius $r_0$. A quasi-linear relationship is found to link the terminal amplitude of the oscillations $X$, to the extent of size change $a$, wit...

  15. Lorentzian AdS, Wormholes and Holography

    CERN Document Server

    Arias, Raul E; Silva, Guillermo A


    We investigate the structure of two point functions for the QFT dual to an asymptotically Lorentzian AdS-wormhole. The bulk geometry is a solution of 5-dimensional second order Einstein Gauss Bonnet gravity and causally connects two asymptotically AdS space times. We revisit the GKPW prescription for computing two-point correlation functions for dual QFT operators O in Lorentzian signature and we propose to express the bulk fields in terms of the independent boundary values phi_0^\\pm at each of the two asymptotic AdS regions, along the way we exhibit how the ambiguity of normalizable modes in the bulk, related to initial and final states, show up in the computations. The independent boundary values are interpreted as sources for dual operators O^\\pm and we argue that, apart from the possibility of entanglement, there exists a coupling between the degrees of freedom leaving at each boundary. The AdS_(1+1) geometry is also discussed in view of its similar boundary structure. Based on the analysis, we propose a ...

  16. Consolidation of the subjects of the Russian Federation as an element of economic development

    Directory of Open Access Journals (Sweden)

    Lev Aleksandrovich Korshunov


    Full Text Available The discussion on the optimality of the currently existing structure of the subjects of the Russian Federation is illustrating the contradictions that have been accumulated in the dominion form of government of our country in recent years. In this paper, we attempt to assess the impact of past enlargements, which are considered as a part of the process called modernization of the country as a whole. A system of criteria for the process of consolidating and enlarging the regions was elaborated. The main criterion proposed is the quality of life in the enlarged regions. Diagnostics of the state, as well as the estimated dynamics of the socio-demographic security of the individual subjects of the Russian Federation, members of the Siberian Federal District in the period 2000-2009, was done. An integrated assessment of the socio-demographic security in the discussed subjects on the basis of estimates was obtained for the six indicative blocks: reproduction of the population, health status, level of life and material well-being of the population, quality of life, migration flows and indicators of age-sex and marriage-family structure.

  17. Baby Skyrmions in AdS

    Energy Technology Data Exchange (ETDEWEB)

    Elliot-Ripley, Matthew; Winyard, Thomas [Department of Mathematical Sciences, Durham University,South Rd, Durham (United Kingdom)


    We study the baby Skyrme model in a pure AdS background without a mass term. The tail decays and scalings of massless radial solutions are demonstrated to take a similar form to those of the massive flat space model, with the AdS curvature playing a similar role to the flat space pion mass. We also numerically find minimal energy solutions for a range of higher topological charges and find that they form concentric ring-like solutions. Popcorn transitions (named in analogy with studies of toy models of holographic QCD) from an n layer to an n+1-layer configuration are observed at topological charges 9 and 27 and further popcorn transitions for higher charges are predicted. Finally, a point-particle approximation for the model is derived and used to successfully predict the ring structures and popcorn transitions for higher charge solitons.

  18. Population Pharmacokinetic and Pharmacodynamic Modeling of Lusutrombopag, a Newly Developed Oral Thrombopoietin Receptor Agonist, in Healthy Subjects. (United States)

    Katsube, Takayuki; Ishibashi, Toru; Kano, Takeshi; Wajima, Toshihiro


    The aim of this study was to develop a population pharmacokinetic (PK)/pharmacodynamic (PD) model for describing plasma lusutrombopag concentrations and platelet response following oral lusutrombopag dosing and for evaluating covariates in the PK/PD profiles. A population PK/PD model was developed using a total of 2539 plasma lusutrombopag concentration data and 1408 platelet count data from 78 healthy adult subjects following oral single and multiple (14-day once-daily) dosing. Covariates in PK and PK/PD models were explored for subject age, body weight, sex, and ethnicity. A three-compartment model with first-order rate and lag time for absorption was selected as a PK model. A three-transit and one-platelet compartment model with a sigmoid E max model for drug effect and feedback of platelet production was selected as the PD model. The PK and PK/PD models well described the plasma lusutrombopag concentrations and the platelet response, respectively. Body weight was a significant covariate in PK. The bioavailability of non-Japanese subjects (White and Black/African American subjects) was 13 % lower than that of Japanese subjects, while the simulated platelet response profiles using the PK/PD model were similar between Japanese and non-Japanese subjects. There were no significant covariates of the tested background data including age, sex, and ethnicity (Japanese or non-Japanese) for the PD sensitivity. A population PK/PD model was developed for lusutrombopag and shown to provide good prediction for the PK/PD profiles. The model could be used as a basic PK/PD model in the drug development of lusutrombopag.

  19. AdS solutions through transgression

    Energy Technology Data Exchange (ETDEWEB)

    Donos, A. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Theory Group; Gauntlett, J.P. [Imperial College, London (United Kingdom). Blackett Lab.]|[Imperial College, London (United Kingdom). The Institute for Mathematical Sciences; Kim, Nakwoo [Kyung Hee Univ., Seoul (Korea). Dept. of Physics and Research Inst. of Basic Science


    We present new classes of explicit supersymmetric AdS{sub 3} solutions of type IIB supergravity with non-vanishing five-form flux and AdS{sub 2} solutions of D=11 supergravity with electric four-form flux. The former are dual to two-dimensional SCFTs with (0,2) supersymmetry and the latter to supersymmetric quantum mechanics with two supercharges. We also investigate more general classes of AdS{sub 3} solutions of type IIB supergravity and AdS{sub 2} solutions of D=11 supergravity which in addition have non-vanishing three-form flux and magnetic four-form flux, respectively. The construction of these more general solutions makes essential use of the Chern-Simons or ''transgression'' terms in the Bianchi identity or the equation of motion of the field strengths in the supergravity theories. We construct infinite new classes of explicit examples and for some of the type IIB solutions determine the central charge of the dual SCFTs. The type IIB solutions with non-vanishing three-form flux that we construct include a two-torus, and after two T-dualities and an S-duality, we obtain new AdS3 solutions with only the NS fields being non-trivial. (orig.)

  20. Is the Non-unitary Subject a Plausible and Productive Way to Understand Development Bureaucrats?

    NARCIS (Netherlands)

    Tamas, P.A.; Sato, C.


    Development bureaucrats are the human instruments of the policies that mobilise funds, create organisations and underwrite interventions. For their home audiences development organisations need to present bureaucrats who are reliable instruments. In the field these same organisations need staff who

  1. Emotions over time: synchronicity and development of subjective, physiological, and facial affective reactions to music. (United States)

    Grewe, Oliver; Nagel, Frederik; Kopiez, Reinhard; Altenmüller, Eckart


    Most people are able to identify basic emotions expressed in music and experience affective reactions to music. But does music generally induce emotion? Does it elicit subjective feelings, physiological arousal, and motor reactions reliably in different individuals? In this interdisciplinary study, measurement of skin conductance, facial muscle activity, and self-monitoring were synchronized with musical stimuli. A group of 38 participants listened to classical, rock, and pop music and reported their feelings in a two-dimensional emotion space during listening. The first entrance of a solo voice or choir and the beginning of new sections were found to elicit interindividual changes in subjective feelings and physiological arousal. Quincy Jones' "Bossa Nova" motivated movement and laughing in more than half of the participants. Bodily reactions such as "goose bumps" and "shivers" could be stimulated by the "Tuba Mirum" from Mozart's Requiem in 7 of 38 participants. In addition, the authors repeated the experiment seven times with one participant to examine intraindividual stability of effects. This exploratory combination of approaches throws a new light on the astonishing complexity of affective music listening.

  2. Hard Times in Higher Education: The Closure of Subject Centres and the Implications for Education for Sustainable Development (ESD

    Directory of Open Access Journals (Sweden)

    Brian Chalkley


    Full Text Available Within many British Universities and, indeed, across higher education internationally, how best to provide education for sustainable development (ESD has become an increasingly important issue. There is now a widespread view that higher education sectors have a key part to play in preparing societies for the transition to a low carbon economy and the shift towards more sustainable ways of living and working. In the UK, a leading role in this field has been played by the Higher Education Academy and especially its network of 24 Subject Centres, each of which promotes curriculum enhancement in a particular discipline area. The mission of the Higher Education Academy has been to help raise the overall quality of the student learning experience across all disciplines and all Higher Education institutions (HEIs. As part of promoting and supporting many kinds of curriculum innovation and staff development, the HE Academy has championed the cause of ESD. Now, however, as a result of government spending cuts, the Academy is facing severe budget reductions and all its Subject Centres are soon to close. At this pivotal moment, the purpose of this paper is, therefore, to review the HE Academy’s past contribution to ESD and to explore the likely future implications of the demise of its Subject Centres. The paper ends by outlining some ideas as to how the ESD agenda might be advanced in the post-Subject Centre era, in the light of the Academy’s intention to support subject communities under its new structure. The paper has been developed through participation in key committees, engagement with Academy and Subject Centre staff, as well as through a literature review.

  3. Ultraviolet asymptotics for quasiperiodic AdS_4 perturbations

    CERN Document Server

    Craps, Ben; Jai-akson, Puttarak; Vanhoof, Joris


    Spherically symmetric perturbations in AdS-scalar field systems of small amplitude epsilon approximately periodic on time scales of order 1/epsilon^2 (in the sense that no significant transfer of energy between the AdS normal modes occurs) have played an important role in considerations of AdS stability. They are seen as anchors of stability islands where collapse of small perturbations to black holes does not occur. (This collapse, if it happens, typically develops on time scales of the order 1/epsilon^2.) We construct an analytic treatment of the frequency spectra of such quasiperiodic perturbations, paying special attention to the large frequency asymptotics. For the case of a self-interacting phi^4 scalar field in a non-dynamical AdS background, we arrive at a fairly complete analytic picture involving quasiperiodic spectra with an exponential suppression modulated by a power law at large mode numbers. For the case of dynamical gravity, the structure of the large frequency asymptotics is more complicated....

  4. Evaluating a Professional Development Programme for Implementation of a Multidisciplinary Science Subject

    National Research Council Canada - National Science Library

    Visser, Talitha Christine; Coenders, Ferdinand G.M; Terlouw, C; Pieters, Julius Marie


    This study aims to evaluate a professional development programme that prepares and assists teachers with the implementation of a multidisciplinary science module, basing the evaluation on participants...

  5. Impaired cognition in depression and Alzheimer (AD: a gradient from depression to depression in AD

    Directory of Open Access Journals (Sweden)

    Narahyana Bom de Araujo


    Full Text Available Objective To assess cognition in major depressed (MD, Alzheimer's disease (AD, and depression in AD elderly. Method Subjects were evaluated by Mini Mental, Rey Auditory Verbal Learning Test, Rey Complex Figure, Digit Span, Similarities, Trail Making A/B, Verbal Fluency and Stroop. One-way ANOVA and multivariate models were used to compare the performance of each group on neuropsychological tests. Results We evaluated 212 subjects. Compared to MD, attention, working memory, processing speed and recall showed significantly better in controls. Controls showed significantly higher performance in all cognitive measures, except in attention compared to AD. Verbal fluency, memory, processing speed and abstract reasoning in MD was significantly higher compared to AD. AD was significantly better in general cognitive state than depression in AD. All other cognitive domains were similar. Conclusion A decreasing gradient in cognition appeared from the control to depression in AD, with MD and AD in an intermediate position.

  6. The Attitude of the College Students to Entrepreneurial Skills Development in the Subject E-Commerce (United States)

    Beránek, Ladislav


    One of the main goals of many educational courses at various colleges, especially those which focus on applied economics and management, is the development of students' entrepreneurship skills. It is usually accomplished through various project-oriented tasks. The development of the students' entrepreneurship skills is also the primary objective…

  7. Model of the Students' Key Competences Development through Interactive Whiteboard in the Subject of Technology (United States)

    Brecka, Peter; Valentová, Monika


    The basis of the submitted study are the continuously rising demands to alter the curricula with the aim to develop students' key competences in order to increase their professional versatility. The lack of scientific research and discussions show that little investigation has been done on the issue of development of key competences. Therefore,…

  8. Comparative Analysis of Participation of Teachers of STEM and Non-STEM Subjects in Professional Development (United States)

    Chiyaka, Edward T.; Kibirige, Joachim; Sithole, Alec; McCarthy, Peter; Mupinga, Davison M.


    School administrators continuously consider teacher professional development (PD) as one of the key strategies to improving teachers' pedagogical skills. Modern proposals for advancing education by improving student learning outcomes are centered on high quality professional development for teachers. However, teachers face a number of barriers…

  9. Predicting AD conversion

    DEFF Research Database (Denmark)

    Liu, Yawu; Mattila, Jussi; Ruiz, Miguel �ngel Mu�oz


    To compare the accuracies of predicting AD conversion by using a decision support system (PredictAD tool) and current research criteria of prodromal AD as identified by combinations of episodic memory impairment of hippocampal type and visual assessment of medial temporal lobe atrophy (MTA) on MRI...

  10. Antismoking Ads at the Point of Sale: The Influence of Ad Type and Context on Ad Reactions. (United States)

    Kim, Annice; Nonnemaker, James; Guillory, Jamie; Shafer, Paul; Parvanta, Sarah; Holloway, John; Farrelly, Matthew


    Efforts are underway to educate consumers about the dangers of smoking at the point of sale (POS). Research is limited about the efficacy of POS antismoking ads to guide campaign development. This study experimentally tests whether the type of antismoking ad and the context in which ads are viewed influence people's reactions to the ads. A national convenience sample of 7,812 adult current smokers and recent quitters was randomized to 1 of 39 conditions. Participants viewed one of the four types of antismoking ads (negative health consequences-graphic, negative social consequences-intended emotive, benefits of quitting-informational, benefits of quitting-graphic) in one of the three contexts (alone, next to a cigarette ad, POS tobacco display). We assessed participants' reactions to the ads, including perceived effectiveness, negative emotion, affective dissonance, and motivational reaction. Graphic ads elicited more negative emotion and affective dissonance than benefits of quitting ads. Graphic ads elicited higher perceived effectiveness and more affective dissonance than intended emotive ads. Antismoking ads fared best when viewed alone, and graphic ads were least influenced by the context in which they were viewed. These results suggest that in developing POS campaigns, it is important to consider the competitive pro-tobacco context in which antismoking ads will be viewed.

  11. Children with Spastic Cerebral Palsy Experience Difficulties Adjusting Their Gait Pattern to Weight Added to the Waist, While Typically Developing Children Do Not (United States)

    Meyns, Pieter; Van Gestel, Leen; Bar-On, Lynn; Goudriaan, Marije; Wambacq, Hans; Aertbeliën, Erwin; Bruyninckx, Herman; Molenaers, Guy; De Cock, Paul; Ortibus, Els; Desloovere, Kaat


    The prevalence of childhood overweight and obesity is increasing in the last decades, also in children with Cerebral Palsy (CP). Even though it has been established that an increase in weight can have important negative effects on gait in healthy adults and children, it has not been investigated what the effect is of an increase in body weight on the characteristics of gait in children with CP. In CP, pre and post three-dimensional gait analyses are performed to assess the effectiveness of an intervention. As a considerable amount of time can elapse between these measurements, and the effect of an alteration in the body weight is not taken into consideration, this effect of increased body weight is of specific importance. Thirty children with the predominantly spastic type of CP and 15 typically developing (TD) children were enrolled (age 3–15 years). All children underwent three-dimensional gait analysis with weight-free (baseline) and weighted (10% of the body weight added around their waist) trials. Numerous gait parameters showed a different response to the added weight for TD and CP children. TD children increased walking velocity, step- and stride length, and decreased double support duration with a slightly earlier timing of foot-off, while the opposite was found in CP. Similarly, increased ranges of motion at the pelvis (coronal plane) and hip (all planes), higher joint angular velocities at the hip and ankle, as well as increased moments and powers at the hip, knee and ankle were observed for TD children, while CP children did not change or even showed decreases in the respective measures in response to walking with added weight. Further, while TD children increased their gastrocnemius EMG amplitude during weighted walking, CP children slightly decreased their gastrocnemius EMG amplitude. As such, an increase in weight has a significant effect on the gait pattern in CP children. Clinical gait analysts should therefore take into account the negative

  12. Predictors of the Development of Elementary-School Children=s Intentions to Smoke Cigarettes: Hostility, Prototypes, and Subjective Norms (United States)

    Hampson, Sarah E.; Andrews, Judy A.; Barckley, Maureen


    Children’s intentions to smoke are reliable predictors of subsequent smoking and precede smoking initiation, so identifying predictors of intentions is important for preventing or delaying smoking initiation. Children’s hostility and sociability, mediated by the development of prototypes (i.e., social images of children who smoke cigarettes) and subjective norms regarding smoking among peers, were expected to predict the development of their intentions to smoke cigarettes in the future. Children in 2nd through 5th grades (N = 809) from a Western Oregon community participated in a longitudinal study. Hostility and sociability were assessed by teachers = ratings, and prototypes, subjective norms, and intentions were assessed by self-report at each of the first four annual assessments. Children’s intentions to smoke predicted whether they had tried cigarettes by the fifth assessment. For both genders, latent growth modeling demonstrated that hostility, but not sociability, predicted the development of smoking intentions. More hostile children were more likely to have higher initial levels of intentions to smoke and, for boys, this effect was mediated by their higher initial levels of subjective norms about smoking. Sociability was not related to the development of smoking cognitions for boys or girls. These results were discussed in terms of opportunities to intervene on early influences on smoking intentions. PMID:17577804

  13. Predictors of the development of elementary-school children's intentions to smoke cigarettes: hostility, prototypes, and subjective norms. (United States)

    Hampson, Sarah E; Andrews, Judy A; Barckley, Maureen


    Children's intentions to smoke are reliable predictors of subsequent smoking and precede smoking initiation; thus identifying predictors of intentions is important for preventing or delaying smoking initiation. Children's hostility and sociability, mediated by the development of prototypes (i.e., social images of children who smoke cigarettes) and subjective norms regarding smoking among peers, were expected to predict the development of their intentions to smoke cigarettes in the future. Children in 2nd through 5th grades (N = 809) from a western Oregon community participated in a longitudinal study. Hostility and sociability were assessed by teachers' ratings, and prototypes, subjective norms, and intentions were assessed by self-report at each of the first four annual assessments. Children's intentions to smoke predicted whether they had tried cigarettes by the fifth assessment. For both genders, latent growth modeling demonstrated that hostility, but not sociability, predicted the development of smoking intentions. Children who were more hostile were more likely to have higher initial levels of intentions to smoke, and for boys this effect was mediated by their higher initial levels of subjective norms about smoking. Sociability was not related to the development of smoking cognitions for boys or girls. These results are discussed in terms of opportunities to intervene in early influences on smoking intentions.

  14. Evaluating a Professional Development Programme for Implementation of a Multidisciplinary Science Subject

    NARCIS (Netherlands)

    Visser, Talitha Christine; Coenders, Ferdinand G.M.; Terlouw, C.; Pieters, Julius Marie


    This study aims to evaluate a professional development programme that prepares and assists teachers with the implementation of a multidisciplinary science module, basing the evaluation on participants’ reactions, the first level of Guskey’s five-level model for evaluation (2002). Positive

  15. Academic Developers as Change Agents Improving Quality in a Large Interprofessional Undergraduate Subject (United States)

    Cordiner, Moira


    Much has been written about academic developers as change agents but not in an interprofessional education (IPE) context. IPE involves teaching students in different health professions how to work effectively in teams across professional boundaries to improve the quality of patient care. Extensive evidence reveals that implementing sustainable IPE…

  16. Thyroid peroxidase antibodies, levels of thyroid stimulating hormone and development of hypothyroidism in euthyroid subjects

    NARCIS (Netherlands)

    Roos, A.; Links, T.P.; de Jong-van den Berg, L.T.; Gans, R.O.; Wolffenbuttel, B.H.; Bakker, S.J.


    Objective: Thyroid peroxidase antibodies (TPOAbs) have been found to be related to the levels of thyroid stimulating hormone (TSH) and to predict future development of thyroid failure in selected populations. We investigated these relations in a euthyroid general population. Design: Cross-sectional

  17. Creative Workshop as a Form of Contemporary Art and a Space for Subjective Development (United States)

    Józefowski, Eugeniusz


    The article presents the original concept of the author's creative workshop which is treated as an art form and the method of education. It contains a presentation of the structure of the original workshop developed by the author in the context of multi-layered relations occurring in the interconnected areas of art and education leading to…

  18. Why do certain consumers avoid new media developments? : An investigation of three prudent users’ subjectivity

    NARCIS (Netherlands)

    Gauttier, Stéphanie; Gauzente, Claire


    New media development constantly challenges consumer’s habits. While innovations are supposed to bring new facilities to users, a certain number of them still remain reluctant in accepting, adopting and using new media offers. The aim of this research is to review the theoretical frameworks that are

  19. It Takes Two to Tango: Studying How Students Constitute Political Subjects in Discourses on Sustainable Development (United States)

    Lundegard, Iann; Wickman, Per-Olof


    A great deal of the ongoing discussion about environmental education and education for sustainable development has to do with democracy and deliberation. Here, for example, the normative approach has been challenged. As an alternative, there is sometimes a call for a curriculum and education that is characterized by democracy, participation, and…

  20. Developing, Using, and Interacting in the Flipped Learning Movement: Gaps among Subject Areas (United States)

    Chen, Hsin-liang; Summers, Kevin L.


    The purpose of this paper is to investigate the current video collection of an open-access video website (TED-Ed). The research questions focus on its content as evidence of development, its viewership as evidence of use, and flipping as evidence of interaction in informal learning. In late September 2013, 686 video lessons were posted on the…

  1. Rhetorical Meta-Language to Promote the Development of Students' Writing Skills and Subject Matter Understanding (United States)

    Pelger, Susanne; Sigrell, Anders


    Background: Feedback is one of the most significant factors for students' development of writing skills. For feedback to be successful, however, students and teachers need a common language--a meta-language--for discussing texts. Not least because in science education such a meta-language might contribute to improve writing training and…

  2. Intra-individual cognitive imbalance in ASD between perceptual reasoning and ambiguity-solving related to tool use: Comparison among children exhibiting ASD, AD/HD, and typical development. (United States)

    Wakusawa, Keisuke; Nara, Chieko; Kubota, Yuki; Tomizawa, Yayoi; Taki, Yasuyuki; Sassa, Yuko; Kobayashi, Satoru; Suzuki-Muromoto, Sato; Hirose, Mieko; Yokoyama, Hiroyuki; Nara, Takahiro; Kure, Shigeo; Mori, Norio; Takei, Noriyoshi; Kawashima, Ryuta


    Several studies have suggested that objective deficits in the processing of abstract information in conjunction with an enhanced ability to process concrete information is a definitive characteristic of autism spectrum disorder (ASD). However, this cognitive imbalance is not necessarily clear in high-functioning autistic individuals who do not display absolute differences relative to typically developing (TD) populations. Thus, the purpose of this study was to identify this cognitive tendency in high-functioning autistic individuals using intra-individual cognitive comparisons. The reaction times (RTs) of TD children, children with ASD, and children with attention deficit hyperactivity disorder (AD/HD) (n=17 in each group, mean age=11.9years, age range=9.8-15.8years) were compared using the Which/How-to-Apply Tools (W/HAT) test, which consists of tasks requiring the adaptive use of novel tools and familiar tools in atypical and typical situations. Differences in RTs between the atypical and typical trials ([A-T]) were used to assess intra-individual cognitive imbalances. As predicted, the [A-T] scores of the ASD group were significantly higher than those of the TD group even though the RTs in the atypical and typical trials did not differ. Additionally, the [A-T] values were significantly higher in the ASD group than in the AD/HD group, which indicates that the cognitive imbalance was specific to ASD individuals. No significant interaction was detected between the trial and subject group. The findings of this study demonstrate that a cognitive imbalance in ASD individuals may enhance the current understanding of the pathophysiology of this disorder, which is found in a range of individuals, including those with obvious cortical dysfunction to those with only intra-individual imbalances. Copyright © 2017 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

  3. [Early mother-infant separation and psychosocial development. II. Longitudinal study on 42 subjects]. (United States)

    Domenici, R; Papini, M A


    It is the purpose of the present investigation to obtain some information as they can be drown from the activity of our follow-up for premature babies and infants at higher risk. The main objectives of the study were: - to evaluate the aspects of parent's emotional status and parent-infant interaction in the first year of life; - to evaluate possible effects of the early separation on later development of the children. We have observed 42 LBW infants (hospitalized at birth for a period of one-three months) and their parents for 7-8 years. Our study has included: interviews with parents, observation of interaction, clinical examinations, designs. Recurrent interactive patterns have been defined in their peculiarities in the first year of life. Patterns of later psychosocial development are also exposed: they are strictly related to the kind of the precocious interaction.


    Directory of Open Access Journals (Sweden)

    rina dwi s, febrian dewanto, bagus ardi s


    The results the influence of motivation and activity of learning achievement of 89.7% d and the average of  learning achievement experimental class achieve exhaustiveness 74.25 e Average learning achievement of  experimental class 74.25, better than average learning achievement for control class 64.57. Based on the research results obtained are valid learning tools and effective learning that show the development of learning tools goals achieved.

  5. The Development of Molecular Gastronomy as a Subject Discipline at the Dublin Institute of Technology


    Burke, Roisin; Danaher, Pauline; Traynor, Mark


    Molecular gastronomy is the study of the physical and chemical culinary transformations that occur during preparation, cooking and consumption. Molecular gastronomy differs from food science as the social, artistic and technical components of culinary and gastronomic phenomena are explored. At the Dublin Institute of Technology (DIT) the aim of developing molecular gastronomy modules is to use them as a tool to teach scientific principles to those who work in the Culinary Arts. Students and g...

  6. Development of a Medical Care Terminal for Efficient Monitoring of Bedridden Subjects

    Directory of Open Access Journals (Sweden)

    Filipe Pereira


    Full Text Available This work is developed in the context of Ambient Assisted Living (AAL and has as main objective the development of a mechatronic system that allows the care of bedridden patients with ongoing medical care handled by a single person. The developed Medical Care Terminal (MCT improves autonomy in home care, safety, comfort, and hygiene of bedridden patients. The MCT has six biomedical sensors and four environmental sensors. Data acquisition and processing is performed using Arduino and LabVIEW platforms, respectively. The proposed solution has, as main feature, its adaptability to the patient needs. One of the MCT functionalities is the remote access to the patient data through the web. The caregiver may request help from a specialist who sends back information in real time to perform first aid assistance. This device has a flexible configuration allowing a fast and cheap reconfiguration according the specific needs of the patient. The proposed mechatronic system intends to meet the needs of bedridden patients improving their quality of life, health, safety, and comfort, while enabling the remote monitoring of the patients.

  7. Application of Fuzzy Borda Combination Evaluation in Subjective and Objective Evaluation Methods in Comprehensive Evaluation of Population Development

    Directory of Open Access Journals (Sweden)

    Yu Jiajia


    Full Text Available This paper constructs the comprehensive index evaluation of population development from the three aspects of human development, population and economic society and population, resources and environment, according to the movement course and changing trend of population development at home and abroad, and the guiding ideology of national population development strategy system. The index system consists of 3 first level indexes, 8 Secondary indexes, 22 tertiary level indexes and 42 fourth level indexes. And on the basis of commonly used comprehensive evaluation methods. The comprehensive evaluation of the population development in China in 2013 was made by using the combined evaluation method, which effectively overcomes the shortcomings of the objective evaluation method and the subjective evaluation method, and obtains a more credible comprehensive evaluation value.


    Directory of Open Access Journals (Sweden)

    Lobov A. A.


    Full Text Available Effective credit policy is an essential condition for bank’s successful operation. In this article methods of developing a credit policy that accounts for information asymmetry and «reverse selection» effect in the credit market are considered. In the course of research, relationships between interest rates, “pass” credit score, total bank’s income, average profitability of a credit product and the amount of capital required to be allocated to a new product, were revealed. Noting these relationships, bank’s credit department is able to set optimal interest rates, credit score and capital, as well as to apply credit rationing, if necessary.

  9. Persistent depression is a significant risk factor for the development of arteriosclerosis in middle-aged Japanese male subjects. (United States)

    Satoh, Hiroki; Fujii, Satoshi; Tsutsui, Hiroyuki


    Depression often coexists with hypertension and various cardiovascular diseases. However, the relationship between depression and the development of arteriosclerosis has not been fully established. We assessed depression and brachial-ankle pulse wave velocity (baPWV) in 828 middle-aged Japanese male subjects at baseline and during 3 years of follow-up. Depression was assessed using Center for Epidemiological Studies-Depression questionnaires, and the study subjects were divided into the following three groups: persistent depression, transient depression and no depression. The number (%) of subjects with persistent, transient and no depression were 104 (12.6), 76 (9.2) and 648 (78.2), respectively. Blood pressure and baPWV did not differ among the three groups at baseline. The changes in the baPWV values (⊿baPWV) correlated significantly and positively with age, body mass index, baseline systolic blood pressure and persistent depression (r = 0.32, P arteriosclerosis in middle-aged Japanese male subjects.

  10. Sexuality in subjects with intellectual disability: an educational intervention proposal for parents and counselors in developing countries. (United States)

    Katz, Gregorio; Lazcano-Ponce, Eduardo


    In developing countries, the study of intellectual disability has enormous knowledge gaps, especially in the areas of intervention, utilization of services and legislation. This article provides information not only for aiding in the potential development of sexuality in individuals with intellectual disability, but also for fostering their social integration. In Mexico and the region, in order to develop educational interventions for promoting sexual health, it is necessary to consider the following priorities: a) mental health professionals should have the knowledge or receive training for carrying out a sexual education and counseling program; b) educational interventions for subjects with intellectual disability should be adapted for the different stages of life (childhood, adolescence and adulthood); c) during childhood, educational intervention should emphasize the concept of public and private conducts; d) in adolescence, intervention should consider the actual mental age and not the chronological age of the subjects receiving intervention; e) the expression of sexuality in the adult with intellectual disability depends on the early incorporation of factors for promoting social inclusion; f) for educational interventions to be successful, it is fundamental that sexual educators and counselors, in addition to working with the clients, also work with their parents and other close family members; g) intervention programs should establish development objectives for developing in persons with intellectual disability a positive attitude towards sexuality and the improvement in self-esteem; h) in subjects with intellectual disability, their linguistic comprehension level should be taken into consideration and techniques for open discussion and non-inductive education should be used; i) social integration programs should address the needs of developing countries and their individuals, since it is not feasible to import external programs due to differences in

  11. Development of a mnemonic screening tool for identifying subjects with Hunter syndrome. (United States)

    Cohn, Gabriel M; Morin, Isabelle; Whiteman, David A H


    The Hunter Outcome Survey (HOS), an international, long-term observational registry of patients with Hunter syndrome, was used to develop a simple mnemonic screening tool (HUNTER) to aid in the diagnosis of Hunter syndrome. Data regarding the prediagnosis prevalence of ten specific signs and symptoms present in individual patients enrolled in the HOS were used to develop the HUNTER mnemonic screening tool. A total score of 6 or greater using a weighting scheme in which certain manifestations were assigned a weight of 2 (facial dysmorphism, nasal obstruction or rhinorrhea, enlarged tongue, enlarged liver, enlarged spleen, joint stiffness) and others assigned a weight of 1 (hernia, hearing impairment, enlarged tonsils, airway obstruction or sleep apnea) correctly identified 95 % of patients who had no family history of Hunter syndrome or who were not diagnosed prenatally. No association between age at diagnosis and HUNTER score was found. The HUNTER mnemonic appears to be a useful screening tool. Further validation in the clinical setting will be necessary to confirm its utility.


    Directory of Open Access Journals (Sweden)



    Full Text Available The development of vetiver grass (Chrysopogon zizanioides L. has been evaluated under differ-ent levels of phosphorus on slopes of the right-side bank of the San Francisco River, in the municipality of Am-paro do São Francisco, SE. Techniques of soil bioengineering were used, characterized by the combination of vegetated riprap with stakes, seedlings of vetiver grass and sediment retainers. The experimental design was randomized blocks with five doses (0, 4, 8, 12, and 16 g pit-1 of simple superphosphate and five replicates. The growth of vetiver seedlings were observed in periods of 30, 60, 90, e 180 days, carrying out the following pa-rameters: number of roots, external root surface, root density, root length, root length density, root and shoot dry weight, root and shoot fresh weight, and shoot length, at each evaluation period. The phosphorus doses and periods of morphological development interacted in all variables of plant biomass mentioned above. Higher superphosphate doses than 9.0 g pit-1 did not offer advantages in terms of cost-benefit for the production of vetiver seedings.

  13. Development of a questionnaire to assess the relative subjective benefits of presbyopia correction. (United States)

    Buckhurst, Phillip J; Wolffsohn, James S; Gupta, Navneet; Naroo, Shehzad A; Davies, Leon N; Shah, Sunil


    To develop a standardized questionnaire of near visual function and satisfaction to complement visual function evaluations of presbyopic corrections. Eye Clinic, School of Life and Health Sciences, Aston University, Midland Eye Institute and Solihull Hospital, Birmingham, United Kingdom. Questionnaire development. A preliminary 26-item questionnaire of previously used near visual function items was completed by patients with monofocal intraocular lenses (IOLs), multifocal IOLs, accommodating IOLs, multifocal contact lenses, or varifocal spectacles. Rasch analysis was used for item reduction, after which internal and test-retest reliabilities were determined. Construct validity was determined by correlating the resulting Near Activity Visual Questionnaire (NAVQ) scores with near visual acuity and critical print size (CPS), which was measured using the Minnesota Low Vision Reading Test chart. Discrimination ability was assessed through receiver-operating characteristic (ROC) curve analysis. One hundred fifty patients completed the questionnaire. Item reduction resulted in a 10-item NAVQ with excellent separation (2.92), internal consistency (Cronbach α = 0.95), and test-retest reliability (intraclass correlation coefficient = 0.72). Correlations of questionnaire scores with near visual acuity (r = 0.32) and CPS (r = 0.27) provided evidence of validity, and discrimination ability was excellent (area under ROC curve = 0.91). Results show the NAVQ is a reliable, valid instrument that can be incorporated into the evaluation of presbyopic corrections. Copyright © 2011 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

  14. Twistor methods for AdS$_5$

    CERN Document Server

    Adamo, Tim; Williams, Jack


    We consider the application of twistor theory to five-dimensional anti-de Sitter space. The twistor space of AdS$_5$ is the same as the ambitwistor space of the four-dimensional conformal boundary; the geometry of this correspondence is reviewed for both the bulk and boundary. A Penrose transform allows us to describe free bulk fields, with or without mass, in terms of data on twistor space. Explicit representatives for the bulk-to-boundary propagators of scalars and spinors are constructed, along with twistor action functionals for the free theories. Evaluating these twistor actions on bulk-to-boundary propagators is shown to produce the correct two-point functions.

  15. Relationship between mathematics teacher subject matter knowledge, pedagogical content knowledge and professional development needs (United States)

    Tajudin, Nor'ain Mohd; Chinnappan, Mohan; Saad, Noor Shah


    Two key variables emerged from the literature review is that Specific Matter Knowledge [SMK] and Pedagogical Content Knowledge [PCK] can influence the mathematics teachers' Professional Development [PD] needs. However, the key variables of SMK and PCK that were being investigated were not defined clearly. Empirical evidence that support relationship between SMK and PD and PCK and PD were not verified. In addition, how does PCK mediate SMK and PD is not clear and somewhat lacking. Therefore, the purpose of this paper was to examine the relationship between primary mathematics teacher's SMK, PCK and PD needs. Results of path analysis with SmartPLS indicated that the direct effect of SMK on PD was mediated via PCK. This data provide support for the claim that PD programs for future teachers of primary mathematics should be driven by a more nuanced understanding of the link between SMK and PCK.

  16. Black and Korean: Racialized Development and the Korean American Subject in Korean/American Fiction

    Directory of Open Access Journals (Sweden)

    Jeehyun Lim


    Full Text Available This article examines the representation of the encounters and exchanges between Asian and black Americans in Sŏk-kyŏng Kang’s “Days and Dreams,” Heinz Insu Fenkl’s Memories of My Ghost Brother, and Chang-rae Lee’s A Gesture Life. While one popular mode of looking at Asian and black Americans relationally in the postwar era is to compare the success of Asian American assimilation to the failure of black Americans, Lim argues that such a mode of comparison cannot account for the ways in which Asian American racialization takes places within the global currents of militarism and migration. Against the popular view that attributes Asian American success to cultural difference, Lim relies on political scientist Claire Kim’s understanding of culture as something that is constructed in the process of racialization to explore how the above texts imagine the terms of comparative racialization between black and Asian Americans. The black-Korean encounters in these texts demand a heuristic of comparative racialization that goes beyond the discussion of the black-white binary as a national construct and seeks the reification and modification of this racial frame as it travels along the routes of US military and economic incursions in the Pacific. Lim suggests that the literary imagining of black-Korean encounters across the Pacific illustrates race and racialization as effects of a regime of economic development that is supported by military aggression.

  17. Development of “OQALE” Based Reference Module for School Geometry Subject and Analysis of Mathematical Creative Thinking Skills (United States)

    Wulandari, N. A. D.; Sukestiyarno, Y. L.


    This research aims to develop an OQALE based reference module for school geometry subject that meets the criteria of a valid and practical. OQALE approach is learning by of O = observation, Q = question, A = Analyze, L = Logic, E = Express. Geometry subject presented in the module are a triangle, the Pythagorean theorem, and rectangular. Mathematical skills of creative thinking shown from four aspects: fluency, flexibility, originality and elaboration. Research procedures in the development of reference module using a strategy of the investigation and development described by [2], which is limited to the sixth stage is leading field testing. The focus of this research is to develop a reference module that is valid, practical and able to increase the mathematical creative thinking skills of students. The testing is limited to three teachers, nine students and two mathematic readers using purposive sampling technique. The data validity, practicality, and creative thinking skills upgrading collected through questionnaires, observations, and interviews and analysed with a valid test, practical test, gain test and qualitative descriptive. The results were obtained (1) the validity of the module = 4.52, which is 4.20 ≤ Vmthinking mathematically nine students through the test of the gain included in the high and medium category. The conclusions of this research are the generated OQALE based reference module for school geometry subjectis valid and practical.

  18. Skil problemerne ad

    DEFF Research Database (Denmark)

    Kaspersen, Peter


    På grundlag af evalueringer og forskning i gymnasiereformen 2005 foreslås det at skille problemerne ad i forskellige niveauer. Herved kan der arbejdes med niveaudelte løsninger.......På grundlag af evalueringer og forskning i gymnasiereformen 2005 foreslås det at skille problemerne ad i forskellige niveauer. Herved kan der arbejdes med niveaudelte løsninger....

  19. Fermionic continuous spin gauge field in (AdS space

    Directory of Open Access Journals (Sweden)

    R.R. Metsaev


    Full Text Available Fermionic continuous spin field propagating in (AdS space–time is studied. Gauge invariant Lagrangian formulation for such fermionic field is developed. Lagrangian of the fermionic continuous spin field is constructed in terms of triple gamma-traceless tensor–spinor Dirac fields, while gauge symmetries are realized by using gamma-traceless gauge transformation parameters. It is demonstrated that partition function of fermionic continuous spin field is equal to one. Modified de Donder gauge condition that considerably simplifies analysis of equations of motion is found. Decoupling limits leading to arbitrary spin massless, partial-massless, and massive fermionic fields are studied.

  20. Introducing ADS 2.0 (United States)

    Accomazzi, Alberto; Kurtz, M. J.; Henneken, E. A.; Grant, C. S.; Thompson, D.; Luker, J.; Chyla, R.; Murray, S. S.


    In the spring of 1993, the Smithsonian/NASA Astrophysics Data System (ADS) first launched its bibliographic search system. It was known then as the ADS Abstract Service, a component of the larger Astrophysics Data System effort which had developed an interoperable data system now seen as a precursor of the Virtual Observatory. As a result of the massive technological and sociological changes in the field of scholarly communication, the ADS is now completing the most ambitious technological upgrade in its twenty-year history. Code-named ADS 2.0, the new system features: an IT platform built on web and digital library standards; a new, extensible, industrial strength search engine; a public API with various access control capabilities; a set of applications supporting search, export, visualization, analysis; a collaborative, open source development model; and enhanced indexing of content which includes the full-text of astronomy and physics publications. The changes in the ADS platform affect all aspects of the system and its operations, including: the process through which data and metadata are harvested, curated and indexed; the interface and paradigm used for searching the database; and the follow-up analysis capabilities available to the users. This poster describes the choices behind the technical overhaul of the system, the technology stack used, and the opportunities which the upgrade is providing us with, namely gains in productivity and enhancements in our system capabilities.

  1. Probing crunching AdS cosmologies

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, S. Prem; Vaganov, Vladislav [Department of Physics, Swansea University,Singleton Park, Swansea SA2 8PP (United Kingdom)


    Holographic gravity duals of deformations of CFTs formulated on de Sitter spacetime contain FRW geometries behind a horizon, with cosmological big crunch singularities. Using a specific analytically tractable solution within a particular single scalar truncation of N=8 supergravity on AdS{sub 4}, we first probe such crunching cosmologies with spacelike radial geodesics that compute spatially antipodal correlators of large dimension boundary operators. At late times, the geodesics lie on the FRW slice of maximal expansion behind the horizon. The late time two-point functions factorise, and when transformed to the Einstein static universe, they exhibit a temporal non-analyticity determined by the maximal value of the scale factor ã{sub max}. Radial geodesics connecting antipodal points necessarily have de Sitter energy E≲ã{sub max}, while geodesics with E>ã{sub max} terminate at the crunch, the two categories of geodesics being separated by the maximal expansion slice. The spacelike crunch singularity is curved “outward” in the Penrose diagram for the deformed AdS backgrounds, and thus geodesic limits of the antipodal correlators do not directly probe the crunch. Beyond the geodesic limit, we point out that the scalar wave equation, analytically continued into the FRW patch, has a potential which is singular at the crunch along with complex WKB turning points in the vicinity of the FRW crunch. We then argue that the frequency space Green’s function has a branch point determined by ã{sub max} which corresponds to the lowest quasinormal frequency.

  2. Development of common metrics for donation attitude, subjective norm, perceived behavioral control, and intention for the blood donation context. (United States)

    France, Janis L; Kowalsky, Jennifer M; France, Christopher R; McGlone, Sarah T; Himawan, Lina K; Kessler, Debra A; Shaz, Beth H


    The Theory of Planned Behavior has been widely used in blood donation research, but the lack of uniform, psychometrically sound measures makes it difficult to draw firm conclusions or compare results across studies. Accordingly, the goal of this study was to develop such measures of donation attitude, subjective norm, perceived behavioral control, and intention. Exploratory and confirmatory factor analyses (CFAs) were conducted on survey responses collected from college students (n = 1080). The resulting scales were then administered to an independent sample of experienced donors (n = 433) for additional CFAs and to test whether the Theory of Planned Behavior model provided a good fit to the data. CFAs conducted on both samples support the use of six-item scales, with two factors each, to measure donation attitude, subjective norm, and perceived behavioral control and a single-factor three-item scale to measure donation intention. Further, structural equation modeling of these measures revealed that the Theory of Planned Behavior provided a strong fit to the data (comparative fit index, 0.976; root mean square error of approximation, 0.041; standardized root mean square residual, 0.055) and accounted for 73.7% of the variance in donation intention. The present findings confirm the applicability of the Theory of Planned Behavior to the blood donation context and more importantly provide psychometric support for the future use of four brief measures of donation attitude, subjective norm, perceived behavioral control, and intention. © 2013 American Association of Blood Banks.

  3. Developing Pedagogical Content Knowledge for Teaching a New Topic: More Than Teaching Experience and Subject Matter Knowledge (United States)

    Chan, Kennedy Kam Ho; Yung, Benny Hin Wai


    Teaching experience has been identified as an important factor in pedagogical content knowledge (PCK) development. However, little is known about how experienced teachers may draw on their previous experience to facilitate their PCK development. This study examined how two experienced high school biology teachers approached the teaching of a newly introduced topic in the curriculum, polymerase chain reaction and their PCK development from the pre-lesson planning phase through the interactive phase to the post-lesson reflection phase. Multiple data sources included classroom observations, field notes, semi-structured interviews and classroom artefacts. It was found that the teachers' previous experience informed their planning for teaching the new topic, but in qualitatively different ways. This, in turn, had a bearing on their new PCK development. Subject matter knowledge (SMK) can not only facilitate but may also hinder this development. Our findings identify two types of experienced teachers: those who can capitalise on their previous teaching experiences and SMK to develop new PCK and those who do not. The critical difference is whether in the lesson planning stage, the teacher shows the disposition to draw on a generalised mental framework that enables the teacher to capitalise on his existing SMK to develop new PCK. Helping teachers to acquire this disposition should be a focus for teacher training in light of continuous curriculum changes.

  4. Empirical Model Development for Predicting Shock Response on Composite Materials Subjected to Pyroshock Loading. Volume 2, Part 1; Appendices (United States)

    Gentz, Steven J.; Ordway, David O.; Parsons, David S.; Garrison, Craig M.; Rodgers, C. Steven; Collins, Brian W.


    The NASA Engineering and Safety Center (NESC) received a request to develop an analysis model based on both frequency response and wave propagation analyses for predicting shock response spectrum (SRS) on composite materials subjected to pyroshock loading. The model would account for near-field environment (approximately 9 inches from the source) dominated by direct wave propagation, mid-field environment (approximately 2 feet from the source) characterized by wave propagation and structural resonances, and far-field environment dominated by lower frequency bending waves in the structure. This document contains appendices to the Volume I report.

  5. Early detection of AD using cortical thickness measurements (United States)

    Spjuth, M.; Gravesen, F.; Eskildsen, S. F.; Østergaard, L. R.


    Alzheimer's disease (AD) is a neurodegenerative disorder that causes cortical atrophy and impaired cognitive functions. The diagnosis is difficult to make and is often made over a longer period of time using a combination of neuropsychological tests, and structural and functional imaging. Due to the impact of early intervention the challenge of distinguishing early AD from normal ageing has received increasing attention. This study uses cortical thickness measurements to characterize the atrophy in nine mild AD patients (mean MMSE-score 23.3 (std: 2.6)) compared to five healthy middle-aged subjects. A fully automated method based on deformable models is used for delineation of the inner and outer boundaries of the cerebral cortex from Magnetic Resonance Images. This allows observer independent high-resolution quantification of the cortical thickness. The cortex analysis facilitates detection of alterations throughout the entire cortical mantle. To perform inter-subject thickness comparison in which the spatial information is retained, a feature-based registration algorithm is developed which uses local cortical curvature, normal vector, and a distance measure. A comparison of the two study groups reveals that the lateral side of the hemispheres shows diffuse thinner areas in the mild AD group but especially the medial side shows a pronounced thinner area which can be explained by early limbic changes in AD. For classification principal component analysis is applied to reduce the high number of thickness measurements (>200,000) into fewer features. All mild AD and healthy middle-aged subjects are classified correctly (sensitivity and specificity 100%).

  6. New Features in ADS Labs (United States)

    Accomazzi, Alberto; Kurtz, M. J.; Henneken, E. A.; Grant, C. S.; Thompson, D.; Di Milia, G.; Luker, J.; Murray, S. S.


    The NASA Astrophysics Data System (ADS) has been working hard on updating its services and interfaces to better support our community's research needs. ADS Labs is a new interface built on the old tried-and-true ADS Abstract Databases, so all of ADS's content is available through it. In this presentation we highlight the new features that have been developed in ADS Labs over the last year: new recommendations, metrics, a citation tool and enhanced fulltext search. ADS Labs has long been providing article-level recommendations based on keyword similarity, co-readership and co-citation analysis of its corpus. We have now introduced personal recommendations, which provide a list of articles to be considered based on a individual user's readership history. A new metrics interface provides a summary of the basic impact indicators for a list of records. These include the total and normalized number of papers, citations, reads, and downloads. Also included are some of the popular indices such as the h, g and i10 index. The citation helper tool allows one to submit a set of records and obtain a list of top 10 papers which cite and/or are cited by papers in the original list (but which are not in it). The process closely resembles the network approach of establishing "friends of friends" via an analysis of the citation network. The full-text search service now covers more than 2.5 million documents, including all the major astronomy journals, as well as physics journals published by Springer, Elsevier, the American Physical Society, the American Geophysical Union, and all of the arXiv eprints. The full-text search interface interface allows users and librarians to dig deep and find words or phrases in the body of the indexed articles. ADS Labs is available at

  7. Entrepreneurs As a Subject of Modern Russian Economy Development: General Characteristics and «Resource Type» Regions Specificity

    Directory of Open Access Journals (Sweden)

    Levin Sergey, N.


    Full Text Available Nowadays, special urgency has the question about the ability of entrepreneurs to act as a subject of the Russian economy development. Analysis of the specificity of targets and resource potential of the modern Russian entrepreneurs is fulfilled in the context of the general features of entrepreneurship development in the countries with "emerging markets". Distinction between "politicized" entrepreneurs, as prevailing type of entrepreneurs in these countries, and "classic" entrepreneurs is shown. Two basic strategies of their behavior in the form of "rent-seeking" and "institutional" entrepreneurship are highlighted. Incentives and constraints of "institutional" entrepreneurship strategies selection made by "politicized" entrepreneurs are considered in the context of assessing the potential of the Russian entrepreneurs as a subject of economic development as well as emerging positive externalities. Analysis is regionalized to consider the specificity of the behavior of entrepreneurs in the economy of the "resource type" regions. Models of "enclave dual economy" and "integrated regional economy" are discrete structural alternatives for "resource type" regions development. "Sectoral" frontiers of net positive externalities that emerge from institutional entrepreneurs’ activity related to the implementation of productive configurations institutions are considered as well as a choice between the "rent-seeking" and "institutional" entrepreneurship. Kemerovo region and Krasnoyarsk region are the basic regions to analyze incentives and constraints of entrepreneurs in the economy of the "resource type" regions. The authors use sociological tools in the form of semi-structured interviews. Initial evaluation of the eight entrepreneurs’ strategies of Kemerovo region and Krasnoyarsk region shows that the most of them used elements of the institutional entrepreneurs’ strategy and focused on the diversification of the regional economy. At the same time

  8. Oral mucosa: an alternative epidermic cell source to develop autologous dermal-epidermal substitutes from diabetic subjects

    Directory of Open Access Journals (Sweden)

    Daniela GUZMÁN-URIBE

    Full Text Available Abstract Oral mucosa has been highlighted as a suitable source of epidermal cells due to its intrinsic characteristics such as its higher proliferation rate and its obtainability. Diabetic ulcers have a worldwide prevalence that is variable (1%-11%, meanwhile treatment of this has been proven ineffective. Tissue-engineered skin plays an important role in wound care focusing on strategies such autologous dermal-epidermal substitutes. Objective The aim of this study was to obtain autologous dermal-epidermal skin substitutes from oral mucosa from diabetic subjects as a first step towards a possible clinical application for cases of diabetic foot. Material and Methods Oral mucosa was obtained from diabetic and healthy subjects (n=20 per group. Epidermal cells were isolated and cultured using autologous fibrin to develop dermal-epidermal in vitro substitutes by the air-liquid technique with autologous human serum as a supplement media. Substitutes were immunocharacterized with collagen IV and cytokeratin 5-14 as specific markers. A Student´s t- test was performed to assess the differences between both groups. Results It was possible to isolate epidermal cells from the oral mucosa of diabetic and healthy subjects and develop autologous dermal-epidermal skin substitutes using autologous serum as a supplement. Differences in the expression of specific markers were observed and the cytokeratin 5-14 expression was lower in the diabetic substitutes, and the collagen IV expression was higher in the diabetic substitutes when compared with the healthy group, showing a significant difference. Conclusion Cells from oral mucosa could be an alternative and less invasive source for skin substitutes and wound healing. A difference in collagen production of diabetic cells suggests diabetic substitutes could improve diabetic wound healing. More research is needed to determine the crosstalk between components of these skin substitutes and damaged tissues.

  9. Antiproton-Decelerator (AD)

    CERN Multimedia

    Laurent Guiraud


    When the Low-Energy Antiproton Ring (LEAR) was stopped in 1996, because of its costly operation, a cheaper way of continuing low-energy antiproton physics was sought. The Antiproton-Collector (AC), added in 1987 to the Antiproton Accumulator (AA) to provide a tenfold intensity increase, was converted into the Antiproton-Decelerator (AD). Antiprotons from the target at 3.5 GeV/c are decelerated to 100 MeV/c, and fast-ejected to the experiments. Major changes were necessary. Above all, the conversion from a constant-field machine to one with a magnetic cycle, modulating the field by an impressive factor 35. New systems for stochastic and electron cooling had to be added. Beam diagnostics at an intensity of only 2E7 antiprotons was a challenge. In 2000, the AD began delivery of antiprotons to the experiments.

  10. AdS nonlinear instability: moving beyond spherical symmetry (United States)

    Dias, Óscar J. C.; Santos, Jorge E.


    Anti-de Sitter (AdS) is conjectured to be nonlinear unstable to a weakly turbulent mechanism that develops a cascade towards high frequencies, leading to black hole formation (Dafermos and Holzegel 2006 Seminar at DAMTP (University of Cambridge) available at, Bizon and Rostworowski 2011 Phys. Rev. Lett. 107 031102). We give evidence that the gravitational sector of perturbations behaves differently from the scalar one studied by Bizon and Rostworowski. In contrast with Bizon and Rostworowski, we find that not all gravitational normal modes of AdS can be nonlinearly extended into periodic horizonless smooth solutions of the Einstein equation. In particular, we show that even seeds with a single normal mode can develop secular resonances, unlike the spherically symmetric scalar field collapse studied by Bizon and Rostworowski. Moreover, if the seed has two normal modes, more than one resonance can be generated at third order, unlike the spherical collapse of Bizon and Rostworowski. We also show that weak turbulent perturbative theory predicts the existence of direct and inverse cascades, with the former dominating the latter for equal energy two-mode seeds.

  11. Avoiding Ad Avoidance: Factors Affecting the Perception of Online Banner Ads (United States)

    Portnoy, Felix


    This dissertation examined the effect of search type, ad saliency, and ad repetition on the perception of online banner advertisements. In the first study, 48 student participants conducted simulated search tasks using mixed factorial design where search type (known-item vs. exploratory) was manipulated within-subject and the banner saliency level…

  12. Differential representation of liver proteins in obese human subjects suggests novel biomarkers and promising targets for drug development in obesity. (United States)

    Caira, Simonetta; Iannelli, Antonio; Sciarrillo, Rosaria; Picariello, Gianluca; Renzone, Giovanni; Scaloni, Andrea; Addeo, Pietro


    The proteome of liver biopsies from human obese (O) subjects has been compared to those of nonobese (NO) subjects using two-dimensional gel electrophoresis (2-DE). Differentially represented proteins were identified by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS)-based peptide mass fingerprinting (PMF) and nanoflow-liquid chromatography coupled to electrospray-tandem mass spectrometry (nLC-ESI-MS/MS). Overall, 61 gene products common to all of the liver biopsies were identified within 65 spots, among which 25 ones were differently represented between O and NO subjects. In particular, over-representation of short-chain acyl-CoA dehydrogenase, Δ(3,5)-Δ(2,4)dienoyl-CoA isomerase, acetyl-CoA acetyltransferase, glyoxylate reductase/hydroxypyruvate reductase, fructose-biphosphate aldolase B, peroxiredoxin I, protein DJ-1, catalase, α- and β-hemoglobin subunits, 3-mercaptopyruvate S-transferase, calreticulin, aminoacylase 1, phenazine biosynthesis-like domain-containing protein and a form of fatty acid-binding protein, together with downrepresentation of glutamate dehydrogenase, glutathione S-transferase A1, S-adenosylmethionine synthase 1A and a form of apolipoprotein A-I, was associated with the obesity condition. Some of these metabolic enzymes and antioxidant proteins have already been identified as putative diagnostic markers of liver dysfunction in animal models of steatosis or obesity, suggesting additional investigations on their role in these syndromes. Their differential representation in human liver was suggestive of their consideration as obesity human biomarkers and for the development of novel antiobesity drugs.

  13. Ad-hoc networking towards seamless communications

    CERN Document Server

    Gavrilovska, Liljana


    Ad-Hoc Networking Towards Seamless Communications is dedicated to an area that attracts growing interest in academia and industry and concentrates on wireless ad hoc networking paradigm. The persistent efforts to acquire the ability to establish dynamic wireless connections from anywhere to anyone with any device without prerequisite imbedded infrastructure move the communications boundaries towards ad-hoc networks. Recently, ad hoc networking has attracted growing interest due to advances in wireless communications, and developed framework for running IP based protocols. The expected degree of penetration of these networks will depend on the successful resolution of the key features. Ad-hoc networks pose many complex and open problems for researchers. Ad-Hoc Networking Towards Seamless Communications reveals the state-of-the-art in wireless ad-hoc networking and discusses some of the key research topics that are expected to promote and accelerate the commercial applications of these networks (e.g., MAC, rout...

  14. Italy-Japan international project-based learning for developing human resources using design of welfare equipment as a subject. (United States)

    Hanafusa, A; Komeda, T; Ito, K; Zobel, P Beomonte


    Project-based learning (PBL) is effective for developing human resources of young students. The design of welfare equipment, such as wheelchairs and gait assistive devices, is taken as the subject in this study because these devices must be fit to their environment, users, and method of use; students must consider the circumstances of each country concerned. The program commenced in 2012 at L'Aquila, Italy, and the Shibaura Institute of Technology, Japan and has been continuing for three years. Students were divided into four groups and discussions were held on how to adapt the equipment to the user and environment. After discussion, they designed and simulated a model of the equipment using CAD. Finally, they presented their designs to each other. Through the program, students had fruitful discussions, exchanged ideas from different cultures, and learned from each other. Furthermore, friendships among the students were nurtured. It is believed that the objective of the program was satisfactorily accomplished.

  15. Development and validation of a subject-specific finite element model of the functional spinal unit to predict vertebral strength. (United States)

    Lee, Chu-Hee; Landham, Priyan R; Eastell, Richard; Adams, Michael A; Dolan, Patricia; Yang, Lang


    Finite element models of an isolated vertebral body cannot accurately predict compressive strength of the spinal column because, in life, compressive load is variably distributed across the vertebral body and neural arch. The purpose of this study was to develop and validate a patient-specific finite element model of a functional spinal unit, and then use the model to predict vertebral strength from medical images. A total of 16 cadaveric functional spinal units were scanned and then tested mechanically in bending and compression to generate a vertebral wedge fracture. Before testing, an image processing and finite element analysis framework (SpineVox-Pro), developed previously in MATLAB using ANSYS APDL, was used to generate a subject-specific finite element model with eight-node hexahedral elements. Transversely isotropic linear-elastic material properties were assigned to vertebrae, and simple homogeneous linear-elastic properties were assigned to the intervertebral disc. Forward bending loading conditions were applied to simulate manual handling. Results showed that vertebral strengths measured by experiment were positively correlated with strengths predicted by the functional spinal unit finite element model with von Mises or Drucker-Prager failure criteria ( R 2  = 0.80-0.87), with areal bone mineral density measured by dual-energy X-ray absorptiometry ( R 2  = 0.54) and with volumetric bone mineral density from quantitative computed tomography ( R 2  = 0.79). Large-displacement non-linear analyses on all specimens did not improve predictions. We conclude that subject-specific finite element models of a functional spinal unit have potential to estimate the vertebral strength better than bone mineral density alone.

  16. Leg joint power output during progressive resistance FES-LCE cycling in SCI subjects: developing an index of fatigue

    Directory of Open Access Journals (Sweden)

    Faghri Pouran D


    Full Text Available Abstract Background The purpose of this study was to investigate the biomechanics of the hip, knee and ankle during a progressive resistance cycling protocol in an effort to detect and measure the presence of muscle fatigue. It was hypothesized that knee power output can be used as an indicator of fatigue in order to assess the cycling performance of SCI subjects. Methods Six spinal cord injured subjects (2 incomplete, 4 complete between the ages of twenty and fifty years old and possessing either a complete or incomplete spinal cord injury at or below the fourth cervical vertebra participated in this study. Kinematic data and pedal forces were recorded during cycling at increasing levels of resistance. Ankle, knee and hip power outputs and resultant pedal force were calculated. Ergometer cadence and muscle stimulation intensity were also recorded. Results The main findings of this study were: (a ankle and knee power outputs decreased, whereas hip power output increased with increasing resistance, (b cadence, stimulation intensity and resultant pedal force in that combined order were significant predictors of knee power output and (c knowing the value of these combined predictors at 10 rpm, an index of fatigue can be developed, quantitatively expressing the power capacity of the knee joint with respect to a baseline power level defined as fatigue. Conclusion An index of fatigue was successfully developed, proportionalizing knee power capacity during cycling to a predetermined value of fatigue. The fatigue index value at 0/8th kp, measured 90 seconds into active, unassisted pedaling was 1.6. This indicates initial power capacity at the knee to be 1.6 times greater than fatigue. The fatigue index decreased to 1.1 at 2/8th kp, representing approximately a 30% decrease in the knee's power capacity within a 4 minute timespan. These findings suggest that the present cycling protocol is not sufficient for a rider to gain the benefits of FES and thus

  17. The Subject-Modeling Approach to Developing the Methodol- ogy Competence of the Future Teachers-Psychologists

    Directory of Open Access Journals (Sweden)

    S. A. Gilmanov


    Full Text Available Any practical activity of a modern specialist requires the methodology knowledge – the ability of setting and transforming goals, operating with summarized approaches and plans, creating and reconstructing them, etc. The paper deals with the role of the methodology competence in professional thinking; the subject-modeling approach to developing the professional thinking and methodology competence is considered regarding the future teachers-psychologists.The substantiation of the above approach is given concerning the content and structure of the competence in question, as well as the students’ personal characteristics. The psychological mechanism of gaining the experience and professional thinking ability is described as interaction of two models – the cognitive and dynamic emotional ones – both reflecting the professional activity. The results of experimental work, based on such methods as analysis, theoretical modeling, supervision and polling, demon- strated the main developing factors of methodology competence: the general culture level, interest to the future profession, the professional activity presentation in educational process. The research results imply the conclusion that the purposeful pedagogic activity based on the methodology competence is necessary for developing the future specialists’ professional thinking. 

  18. Development of a Patient-Derived Induced Pluripotent Stem Cell Model for the Investigation of SCN5A-D1275N-Related Cardiac Sodium Channelopathy. (United States)

    Hayano, Mamoru; Makiyama, Takeru; Kamakura, Tsukasa; Watanabe, Hiroshi; Sasaki, Kenichi; Funakoshi, Shunsuke; Wuriyanghai, Yimin; Nishiuchi, Suguru; Harita, Takeshi; Yamamoto, Yuta; Kohjitani, Hirohiko; Hirose, Sayako; Yokoi, Fumika; Chen, Jiarong; Baba, Osamu; Horie, Takahiro; Chonabayashi, Kazuhisa; Ohno, Seiko; Toyoda, Futoshi; Yoshida, Yoshinori; Ono, Koh; Horie, Minoru; Kimura, Takeshi


    TheSCN5Agene encodes the α subunit of the cardiac voltage-gated sodium channel, NaV1.5. The missense mutation, D1275N, has been associated with a range of unusual phenotypes associated with reduced NaV1.5 function, including cardiac conduction disease and dilated cardiomyopathy. Curiously, the reported biophysical properties ofSCN5A-D1275N channels vary with experimental system.Methods and Results:First, using a human embryonic kidney (HEK) 293 cell-based heterologous expression system, theSCN5A-D1275N channels showed similar maximum sodium conductance but a significantly depolarizing shift of activation gate (+10 mV) compared to wild type. Second, we generated human-induced pluripotent stem cells (hiPSCs) from a 24-year-old female who carried heterozygousSCN5A-D1275N and analyzed the differentiated cardiomyocytes (CMs). AlthoughSCN5Atranscript levels were equivalent between D1275N and control hiPSC-CMs, both the total amount of NaV1.5 and the membrane fractions were reduced approximately half in the D1275N cells, which were rescued by the proteasome inhibitor MG132 treatment. Electrophysiological assays revealed that maximum sodium conductance was reduced to approximately half of that in control hiPSC-CMs in the D1275N cells, and maximum upstroke velocity of action potential was lower in D1275N, which was consistent with the reduced protein level of NaV1.5. This study successfully demonstrated diminished sodium currents resulting from lower NaV1.5 protein levels, which is dependent on proteasomal degradation, using a hiPSC-based model forSCN5A-D1275N-related sodium channelopathy.

  19. Segmentation and quantification for Alzheimer's disease (AD): a preliminary study (United States)

    Lei, Tianhu; Udupa, Jayaram K.; Zhuge, Ying; Moonis, Gul; Clark, Christopher


    Alzheimer's is a progressive brain disease and is clinically characterized by cognitive symptoms that, in combination with behavioral disturbances, significantly interfere with activities of daily living. The purpose of this study is to investigate the possibility of developing volumetric measures of the structural damage and atrophy of brain derived from multiprotocol MR imaging. Our approach first applies intensity inhomogeneity correction and intensity standardization to PD and T2 weighted MR images to create base images for quantitative image analysis. Then, vectorial scale-based fuzzy connectedness segmentation (VSFCS) and morphological operations are applied to the base images to extract masks of cerebrospinal fluid (CSF), grey matter (GM), and white matter (WM), and further to create a clean and accurate intracranial (IC) mask. After separating CSF from brain parenchyma (BP), VSFCS is applied to BP (PD and T2) images to generate pure GM and WM masks, and then subtracting these pure from the BP mask to detect AD lesions. This method was applied to a set of conventional PD and T2 weighted MR images that were obtained from 5 patients with probable AD and 5 healthy normal control subjects. The segmented images of individual brain tissue regions (CSF, GM, WM, and AD lesion) are consistent with a Neuroradiologist's examination. The quantitative analysis shows that patients with AD have more atrophy. The mean value of the volume of brain parenchyma of patients with AD is about 10% less than that of healthy controls.

  20. Adding and Deleting Images (United States)

    Images are added via the Drupal WebCMS Editor. Once an image is uploaded onto a page, it is available via the Library and your files. You can edit the metadata, delete the image permanently, and/or replace images on the Files tab.

  1. What Value "Value Added"? (United States)

    Richards, Andrew


    Two quantitative measures of school performance are currently used, the average points score (APS) at Key Stage 2 and value-added (VA), which measures the rate of academic improvement between Key Stage 1 and 2. These figures are used by parents and the Office for Standards in Education to make judgements and comparisons. However, simple…

  2. Adding an extra storey

    DEFF Research Database (Denmark)

    Engelmark, Jesper; Dahl, Torben; Melgaard, Ebbe


    of them had to be renovated after a shorter period. In stead of just replacing the original roof with a new one, it is now a days rather common to ad an extra storey where that is possible according to local planning. The reason is as a rule based on economical benefits, but very often this extra storey...

  3. Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects

    Directory of Open Access Journals (Sweden)

    Abdulla Salim


    Full Text Available Abstract Background Efforts to ease administration and enhance acceptability of the oral anti-malarial artemether-lumefantrine (A-L crushed tablet to infants and children triggered the development of a novel dispersible tablet of A-L. During early development of this new formulation, two studies were performed in healthy subjects, one to evaluate the palatability of three flavours of A-L, and a second one to compare the bioavailability of active principles between the dispersible tablet and the tablet (administered crushed and intact. Methods Study 1 was performed in 48 healthy schoolchildren in Tanzania. Within 1 day, all subjects tasted a strawberry-, orange- and cherry-flavoured oral A-L suspension for 10 seconds (without swallowing in a randomized, single-blind, crossover fashion. The palatability of each formulation was rated using a visual analogue scale (VAS. Study 2 was an open, randomized crossover trial in 48 healthy adults given single doses of A-L (80 mg artemether + 480 mg lumefantrine with food. The objectives were to compare the bioavailability of artemether, dihydroartemisinin (DHA and lumefantrine between the dispersible tablet and the tablet administered crushed (primary objective and intact (secondary objective. Results Study 1 showed no statistically significant difference in VAS scores between the three flavours but cherry had the highest score in several ratings (particularly for overall liking. Study 2 demonstrated that the dispersible and crushed tablets delivered bioequivalent artemether, DHA and lumefantrine systemic exposure (area under the curve [AUC]; mean ± SD AUC0-tlast were 208 ± 113 vs 195 ± 93 for artemether, 206 ± 81 vs 199 ± 84 for DHA and 262 ± 107 vs 291 ± 106 h.μg/ml for lumefantrine. Bioequivalence was also shown for peak plasma concentrations (Cmax of DHA and lumefantrine. Compared with the intact tablet, the dispersible tablet resulted in bioequivalent lumefantrine exposure, but

  4. Subjective need for psychological support (PsySupp) in parents of children and adolescents with disorders of sex development (dsd). (United States)

    Bennecke, Elena; Werner-Rosen, Knut; Thyen, Ute; Kleinemeier, Eva; Lux, Anke; Jürgensen, Martina; Grüters, Annette; Köhler, Birgit


    Disorders/diversity of sex development (dsd) is an umbrella term for congenital conditions often diagnosed within childhood. As most parents are unprepared for this situation, psychological support (PsySupp) is recommended. The aim of this study was to analyse the extent to which parents express a need for PsySupp. Three hundred twenty-nine parents of children with dsd were included; 40.4 % of the parents indicated to have a need for PsySupp, only 50 % of this group received it adequately. The diagnoses partial gonadal dysgenesis, partial androgen insensitivity syndrome (pAIS) and disorders of androgen synthesis are associated with a high need for PsySupp in parents (54, 65, and 50 %). Sex assignment surgery neither reduced nor increased the need for PsySupp. Taking a picture, radiography, laparoscopy, gonadal biopsy, gonadectomy and hormonal puberty induction are associated with a high need for PsySupp. There was no association between the need for PsySupp and the parents' perception of the appearance of the genitalia. Having a child with dsd is associated with a high need for PsySupp in parents. In particular, parents of children with XY-dsd with androgen effects other than hypospadias expressed a high need of PsySupp. PsySupp for parents should be an obligatory part of interdisciplinary care to reduce fears and concerns. What is known • In parents, having a child with dsd provokes insecurities and fears. Hence, psychological support is recommended as part of the interdisciplinary care. What is new • This is the first study investigating the subjective need for psychological support in a large sample of parents of children with dsd in Germany. We present data on the subjective need for psychological support of the parents, related diagnoses and factors, which should be considered in psychological counselling.

  5. [Development and evaluation of ExSel Test to screen for excess salt intake in hypertensive subjects]. (United States)

    Girerd, X; Villeneuve, F; Deleste, F; Giral, P; Rosenbaum, D


    Development of a test to screen excess salt intake (ESI) in hypertensive patients. Hypertensive subjects living in Paris area have been included. A 24-hour urinary sodium collection has been performed the day before the visit for a day hospital. A food diary was completed on the day of the urine collection and validated after an interview with a dietetician. An ESI was defined by a urinary sodium ≥ 200mmol/d. Clinical or food characteristics associated to an ESI were retained for the ExSel Test variables. A ROC curve was performed to determine the optimal score for the ExSel Test in detection of ESI in hypertensive patients. One hundred and forty-eight hypertensive patients have been included living in the Île-de-France area. ESI was observed in 19% with a higher frequency in men. Seven major determinants of ESI have been identified and are the questions that constitute the ExSel Test. A positive response assigns points: man (1); BMI > 30 (2); bread 4 or 5 pieces per day (1) or more than 6 pieces; cheese at least 1 time per day (2); charcuterie at least 2 times per week (2); use of processed broth or pilaf (1); food rich in hidden salt (pizza, cheeseburger, quiche, shrimp, potato chips, smoked fish, olive) at least 2 times per week (1). The ROC curve analysis shows that a score of 5 or more has the best Youden index with a sensitivity of 0.63, specificity of 0.95, PPV of 0.75, NPV of 0.92. In hypertensive subjects, an excessive salt intake can be detected by the realization of the ExSel Test based only on a simple food-questionnaire and some clinical parameters. For a clinical use of the ExSel Test, an electronic version is available on Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  6. [Development of a Japanese version of the Subjective Happiness Scale (SHS), and examination of its validity and reliability]. (United States)

    Shimai, Satoshi; Otake, Keiko; Utsuki, Narisuke; Ikemi, Akira; Lyubomirsky, Sonja


    The purpose of the present study was to develop a Japanese version of the Subjective Happiness Scale (SHS) and to examine its validity and reliability. The four items of the English SHS were translated into Japanese. These Japanese items were back-translated into English, and verified by one of the developers of the original SHS. The participants were 364 Japanese undergraduate students (158 males and 206 females). They were asked to answer the questionnaire including the Japanese SHS, five items concerning positive health and self-esteem, and the Japanese General Health Questionnaire (GHQ). The stability of the Japanese SHS was examined over a five-week time period. It was shown that the Japanese SHS was highly internal consistent with alphas of .80 for males and .84 for females. As for the test-rest reliability, a high correlation (r = .86) was found after five-week. One factor structure and factor loadings emerged clearly from factor analysis. The scores of the Japanese SHS correlated positively with positive health and self-esteem. Furthermore, they were significantly greater in the healthy group than in the unhealthy one, from the GHQ scores, especially for depression. These findings suggest that the Japanese version of SHS has internal consistency, test-retest reliability, convergent validity, and discriminant validity.

  7. Communications after AD2000

    CERN Document Server

    Hilsum, C; Rudge, A


    The Royal Society has initiated a series of meetings to discuss the effect advances in technology will have on our way of life in the next century. The two previous meetings have been concerned with housing and waste treat­ ment. The subject of the third meeting, communications, is no less critical to life, but it offers particular problems and uncertainties, especially in the forecasting of future trends. Indeed, some have doubted if there can be profitable debate on long-term development in such a fast-moving field. The importance of the topic justifies an attempt, and the reader will judge whether the authors have met the challenge. Communications today bears little resemblance to that of the 1970s. Then we knew about satellites and optical fibres, and we had seen lasers and silicon chips, but most of us could never imagine the potential of the new technologies within our grasp. We had also not assessed the thirst of the popUlation for more and better ways of talking and writing to each other. It was the ...

  8. Collapse and Nonlinear Instability of AdS Space with Angular Momentum (United States)

    Choptuik, Matthew W.; Dias, Óscar J. C.; Santos, Jorge E.; Way, Benson


    We present a numerical study of rotational dynamics in AdS5 with equal angular momenta in the presence of a complex doublet scalar field. We determine that the endpoint of gravitational collapse is a Myers-Perry black hole for high energies and a hairy black hole for low energies. We investigate the time scale for collapse at low energies E , keeping the angular momenta J ∝E in anti-de Sitter (AdS) length units. We find that the inclusion of angular momenta delays the collapse time, but retains a t ˜1 /E scaling. We perturb and evolve rotating boson stars, and find that boson stars near AdS space appear stable, but those sufficiently far from AdS space are unstable. We find that the dynamics of the boson star instability depend on the perturbation, resulting either in collapse to a Myers-Perry black hole, or development towards a stable oscillating solution.

  9. The NeckPix(©): development of an evaluation tool for assessing kinesiophobia in subjects with chronic neck pain. (United States)

    Monticone, Marco; Vernon, Howard; Brunati, Roberto; Rocca, Barbara; Ferrante, Simona


    To develop and validate NeckPix(©), a multi-image instrument for assessing daily activities in the context of pain-related fear, in order to allow its use in patients with chronic neck pain (NP). The measure was developed by means of item generation followed by reduction/selection. The psychometric testing included exploratory factor analysis; content validity by investigating clarity, specificity, appropriateness for the target population, relevance and completeness; reliability by internal consistency (Cronbach's alpha) and test-retest stability (intra-class coefficient correlation, ICC); and construct validity by comparing NeckPix with the Tampa Scale of Kinesiophobia (TSK), the Pain Catastrophising Scale (PCS), the Neck Disability Index (NDI) and a Numerical Rating Scale of pain intensity (NRS) (Pearson's correlation). The measure, which includes ten images used to assess everyday activities in the context of pain-related fear, was administered to 118 subjects with chronic non-specific NP, and proved to be acceptable and feasible. Factor analysis revealed a one-factor solution (which explained 71.12 % of variance). The content of the images was considered adequate, appropriate for the target population, comprehensive, and relevant for evaluating activity-related kinesiophobia. The instrument's internal consistency was good (α = 0.954), as was its test-retest stability (ICC 0.979). Construct validity demonstrated a close correlation with the TSK (r = 0.759), and moderate correlations with the PCS (r = 0.583), the NDI (r = 0.520), and a NRS (r = 0.455). NeckPix(©), which was successfully developed following international recommendations, proved to have a good factorial structure and satisfactory psychometric properties. Its use is recommended for research purposes.

  10. Ads in Indonesia

    Directory of Open Access Journals (Sweden)

    Wulan Roro Retno


    Full Text Available Cosmetics industry created the beauty myth for women through advertising. A cosmetic ad in Indonesia has spread a new concept of white skin: East Asia beauty myth. The white concept of Asia white skin basically derived from colonial legacy. The purpose of the research was analyzing the beauty myth in Indonesia ads using postcolonial perspective. The principal result brought the discourse analysis and postcolonial perspective a new insight in communication research. Particularly on media and cultural studies. Major conclusions showed that the beauty myth since the Dutch colonial period never been change. The main concept is always in colonialism’s idea: “white is better”. The West is better than the East.

  11. Management job ads

    DEFF Research Database (Denmark)

    Holmgreen, Lise-Lotte


    jobs by discursively constructing job ads that appeal to both sexes. This argument is part of the broader field of corporate social responsibility, corporate citizenship, and stakeholder management, which involves discussions of the obligations of corporations to acknowledge and mitigate......The article asks whether it is not the responsibility of corporations to address the issue of women being underrepresented in Danish management jobs. In other words, it is argued that corporations should be encouraged to engage more actively in the recruitment of both men and women for management...... the increasingly widespread impact that their activities have on communities and social structures. The article emphasises the need for more active engagement on the part of corporations by analysing the discursive construction of preferred candidates in a small sample of Danish management job ads. By means...


    Directory of Open Access Journals (Sweden)

    S E Mansurova


    Full Text Available Activity approach, differently refracted at different levels of education, has put many new challenges for teachers. The competence approach acts as the methodological basis of the state educational standard of higher professional education, additional professional education; the system-activity approach acts as the methodological basis of the standards of General education. With regard to teachers of General education, the main task is to overcome the contradiction between the real level of their qualifications and new high requirements for them. These requirements are outlined in the leading normative documents of the educational standards, Professional standard “Teacher”. For the system of teacher professional development the authors of this article propose an integrated approach that combines competence-based and system-activity approaches. The integrated approach differs substantially for teachers who teach subjects of Humanities and science profiles. The paper presents the examples of tasks for various categories of teachers, the specifics of the project and research activities, as well as the characteristics of the process of problematization in the classroom and in extracurricular activities of the teachers. The universal educational actions are differenciated from the position of the variable component. At the same time the authors understand the necessity of taking into account the invariant component in the teaching of humanitarian and natural science disciplines. This thesis is a reflection of the general trend towards integration and interdisciplinarity.

  13. Pattern of follicular development in sheep subjected to ovarian superstimulation after follicular ablation by laparoscopic ovum pick-up

    Directory of Open Access Journals (Sweden)

    Renan Denadai

    Full Text Available ABSTRACT: The aim of this study was to determine the pattern of follicular development in ewes following ablation of all follicles associated with ovarian superstimulatory treatment. After confirmation of reproductive cyclicity using ultrasonography and progesterone levels, five adult ewes of undetermined breed received a vaginal pessary containing 60mg of medroxyprogesterone, maintained for 10 days, with the application of 100μg cloprostenol on the fourth day. On the tenth day, 300UI equine chorionic gonadotropin (eCG was applied together with 80mg FSH, and all visible follicles were aspirated by laparoscopic ovum pick-up (LOPU. Following LOPU, ovarian structures were assessed using sonography every 8 hours for a period of 64 hours, and the number and diameter of small (4.5mm follicles were recorded. The average diameter of small follicles reduced from 5.6±1.5mm initially to 0.8±1.3mm by 56 hours. Population size of the medium-sized follicles during the observation period followed a parabolic distribution wherein the theoretical maximum size emerged at 34.6 hours with no difference at (P>0.05 24 (4.6±1.5 and 48 hours (4.8±2.3. It was concluded that in ewes subjected to ovarian superstimulation immediately following LOPU, follicular development is characterized by a new wave of follicle growth with a predominance of medium-sized follicles (2.5-4.5mm between 24 and 48 hours, and a theoretical population maximum occured at 34.6 hours.

  14. Physiological Responses and Ovarian Development of Female Chinese Mitten Crab Eriocheir sinensis Subjected to Different Salinity Conditions

    Directory of Open Access Journals (Sweden)

    Xiaowen Long


    Full Text Available Salinity plays a key role affecting ovarian development, osmoregulation and metabolism of female Chinese mitten crab, Eriocheir sinensis during reproductive migration. In this study, female E. sinensis after their puberty molt were subjected to four salinities of 0, 6, 12, and 18‰ for 40 days to investigate the salinity effects on their ovarian development as well as a range of important physiological parameters. Elevated salinity accelerated the ovarian development with ovigerous crabs found at salinity treatments of 12 and 18‰ despite no copulation had occurred. Meanwhile the survival rate of female crabs showed a decreasing trend with increasing salinity. Higher salinity also led to increased hemolymph Na+, K+, Ca2+, Cl−, and Mg2+ concentrations. The 6‰ treatment had the highest contents of hemolymph total and major free amino acids while the Na+/K+ -ATPase activity in the posterior gills was the lowest among treatments. Total n-3 polyunsaturated fatty acids (∑n-3PUFA and n-3/n-6 PUFA ratio in the anterior gills showed a decreasing trend with salinity while 18‰ had the highest ∑PUFA and ∑n-6PUFA. The ∑n-3PUFA content and n-3/n-6 PUFA ratio of the posterior gills showed a fluctuating pattern and the highest value was detected at 0‰, while an increasing trend was found for the ∑n-6PUFA with increasing salinity. The hemolymph glucose showed a decreasing trend with increasing salinity and the highest total cholesterol in hemolymph was detected at 12‰. The 18‰ treatment had the highest levels of hemolymph γ-glutamyltransferase, alkaline phosphatase and acid phosphatase, as well as glucose, urea and acid phosphatase in hepatopancreas while the highest hemolymph superoxide dismutase and malondialdehyde were detected at 0‰. Overall, the results showed that salinity increase from freshwater to brackish conditions led to lower metabolism, accelerated ovarian development, and the appearance of ovigerous crabs without


    Directory of Open Access Journals (Sweden)

    Chernyshov Alexander V.


    Full Text Available The music-compositional principles of commercial and political advertising and also the self-promotion of electronic media (radio, television, Internet are considered in this mediatext: from the elementary beeps, symbolic functions, emblems/logos and musical brands to the sound engineering technology to underscore the product's name and the complex synthesis between music and intra movements and color-light design of frames. Simultaneously examines, how the musical arrangement of ethereal advertising is involved in creation the emotional drama or bravado which reach the level of explicit or associative counterpoint 'music with the advertised object or subject' and which extend to expression of cultural image of all the broadcast channel. The article explores the works of the next genres like infomercial, teleshopping, film-ad, and autonomous commercials that have been produced in European countries or USA.

  16. Effects of glycemic load on metabolic risk markers in subjects at increased risk of developing metabolic syndrome. (United States)

    Vrolix, Ruth; Mensink, Ronald P


    Epidemiologic studies suggest that diets with a low glycemic index (GI) or glycemic load (GL) are associated with a decreased risk of developing metabolic syndrome. Intervention studies are inconsistent, however, possibly due to differences in macronutrient and fiber compositions of the experimental diets. We tested side-by-side test foods with similar macronutrient and fiber compositions but with different sucrose-flour ratios or carbohydrate source to determine the effects of different GIs and GLs on metabolic risk markers in overweight subjects. Overweight men (n = 9) and women (n = 6) received in random order for 11 wk 4 test foods with an increased GI or a decreased GI (69 compared with 40, 86 compared with 48, 63 compared with 37, and 51 compared with 20, respectively). There was a GL difference of 32 units between the 2 interventions. At the end of the 11-wk intervention periods, the decreased GL test foods did not change fasting plasma glucose (mean +/- SD: 5.83 +/- 0.6 compared with 5.94 +/- 0.6 mmol/L) or insulin (8.3 +/- 2.8 compared with 9.8 +/- 5.1 mU/L) concentrations compared with increased GL test foods. Serum total cholesterol (5.56 +/- 0.90 compared with 5.76 +/- 1.04 mmol/L), LDL-cholesterol (3.57 +/- 0.72 compared with 3.68 +/- 0.80 mmol/L), HDL-cholesterol (1.21 +/- 0.38 compared with 1.24 +/- 0.37 mmol/L), and triacylglycerol (1.61 +/- 0.77 compared with 1.78 +/- 1.04 mmol/L) concentrations were also not significantly different for decreased and increased GL test foods, respectively. Finally, proinflammatory (high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-alpha, monocyte chemoattractant protein 1) and prothrombotic (plasminogen activator inhibitor 1) markers were not affected. Glucose and lipids were also analyzed after 1 and 5 wk of intervention and were not affected by the intervention. When incorporated into a habitual diet, consumption of test foods with a decreased GL does not ameliorate metabolic risk markers

  17. AdS 3-manifolds and Higgs bundles

    DEFF Research Database (Denmark)

    Alessandrini, Daniele; Li, Qiongling


    In this paper we investigate the relationships between closed AdS $3$-manifolds and Higgs bundles. We have a new way to construct AdS structures that allows us to see many of their properties explicitly, for example we can recover the very recent formula by Tholozan for their volume. We give natu...

  18. Dressing phases of AdS3/CFT2

    NARCIS (Netherlands)

    Borsato, R.; Olsson Sax, O.E.; Sfondrini, A.; Stefanski, B.; Torrielli, A.


    We determine the all-loop dressing phases of the AdS3/CFT2 integrable system related to type IIB string theory on AdS3×S3×T4 by solving the recently found crossing relations and studying their singularity structure. The two resulting phases present a novel structure with respect to the ones

  19. The Effects of Mixture of Plant Extracts and Oils are Added to Syrup on Honey Bee Colony Development and Honey Yield

    Directory of Open Access Journals (Sweden)

    Ali Bekret


    Full Text Available This study during the spring of 2014, effects of plant extract and oil mixture obtained from various plants added to the syrup given to the forces equalized bee on physiological characteristics of the colonies were examined. Bee colonies (10 colonies in each group were randomly divided into two groups. When the first group feed syrup and plant extract oil mixture, at the same rate with feed syrup only test group to control group (1/1 sucrose-water was applied. According to the research results, the plant extract-oil mixture was not effective on the number of frames and hive weight. The mixture although numerically increased the amount of brood rearing area, this effect was not statistically significant. However, provided statistically significant increase in honey production. We concluded that, while the plant extract-oil mixture tested is not effective in brood production, is effective on honey production.

  20. Subjective and objective traumatic death: distinct roles in developing complicated grief and depression among older adults in Hong Kong. (United States)

    Tang, Suqin; Chow, Amy Y M


    Symptoms of complicated grief are associated with a traumatic death. However, the subjective experience of whether or not the death was considered traumatic has not been substantially explored. This study first examined the difference between objective and subjective traumatic death, and then investigated their respective impacts on complicated grief and depressive symptoms following bereavement among older adults in Hong Kong. Participants were 187 Hong Kong adults aged 65 years or above who had lost a family member within the past five years. Demographic information, the Inventory of Complicated Grief (ICG), the Geriatric Depression Scale (GDS), and the anxiety subscale of the Hospital Anxiety and Depression Scale (HADS) were utilized. The subjective traumatic level of the death did not differ between the objective traumatic and non-traumatic death as defined by nature of death (t = -1.554, p = 0.122). Higher subjective traumatic levels and younger age of the deceased, were positively related to complicated grief symptoms, F (10, 161) = 14.222, p subjective traumatic levels and older age of the bereaved were positively associated with symptoms of depression, F (10, 160) = 2.855, p = 0.003, R 2 = 0.151. However, objective traumatic death was found to have no relation to either complicated grief or depressive symptoms. Subjective and objective traumatic death may be two distinct concepts, and the subjective experience of the death as a trauma may be a more important factor that contributes to complicated grief and depressive symptoms.

  1. Design of a model for a professional development programme for a multidisciplinary science subject in the Netherlands.

    NARCIS (Netherlands)

    Visser, Talitha Christine; Coenders, Ferdinand G.M.; Terlouw, C.; Pieters, Julius Marie


    Schools are increasingly integrating multidisciplinary education into their programmes. The Minister of Education, Culture and Science has introduced a new, integrated science subject in secondary education in the Netherlands, called Nature, Life and Technology (NLT). This research note describes

  2. Sodium content and sodium efflux of mononuclear leucocytes from young subjects at increased risk of developing essential hypertension

    DEFF Research Database (Denmark)

    Pedersen, K E; Nielsen, J R; Klitgaard, N A


    , and to analyze whether any such changes were associated with borderline hypertension and/or heredity. Four groups of subjects were evaluated: 28 normotensive (NTO) and 20 borderline hypertensive (BHO) offspring of hypertensives, 12 borderline hypertensives with normotensive parents (BH) and 28 normotensive...... subjects with normotensive parents (NT). The cellular sodium/potassium contents of the four groups were not discernibly different. Ouabain insensitive sodium efflux rate constant and corresponding absolute efflux were significantly increased in offspring of hypertensives. Ouabain sensitive absolute sodium...

  3. Value-Added Exchange Rates


    Rudolfs Bems; Robert C. Johnson


    This paper updates the conceptual foundations for measuring real effective exchange rates (REERs) to allow for vertical specialization in trade. We derive a value-added REER describing how demand for the value added that a country produces changes as the price of its value added changes relative to competitors. We then compute this index for 42 countries from 1970-2009 using trade measured in value added terms and GDP deflators. There are substantial differences between value-added and conven...

  4. So Much to Learn, so Little Time...: Pre-Service Physical Education Teachers' Interpretations and Development of Subject Knowledge as They Learn to Teach (United States)

    Herold, Frank Andreas; Waring, Michael


    This paper explores the development of pre-service teachers during a one-year programme of initial teacher training and education (ITTE) of secondary physical education (PE) in England. It concentrates in particular on the interpretation and development of different dimensions of subject knowledge during different phases of their ITTE programme.…

  5. Wireless Ad Hoc Networks

    Directory of Open Access Journals (Sweden)

    Hong-Chuan Yang


    Full Text Available We study the energy-efficient configuration of multihop paths with automatic repeat request (ARQ mechanism in wireless ad hoc networks. We adopt a cross-layer design approach and take both the quality of each radio hop and the battery capacity of each transmitting node into consideration. Under certain constraints on the maximum tolerable transmission delay and the required packet delivery ratio, we solve optimization problems to jointly schedule the transmitting power of each transmitting node and the retransmission limit over each hop. Numerical results demonstrate that the path configuration methods can either significantly reduce the average energy consumption per packet delivery or considerably extend the average lifetime of the multihop route.

  6. Pengukuran Kinerja Keuangan dengan Pendekatan Egonomic Value Added dan Financial Value Added




    Performance measurement has become an important indicator not only for companies but also for investors. It indicates the capability of companies in managing their capital. Performance measurement can be divided into financial and non-financial performance measurement. This article will discuss further about financial performance measurement using Economic Value Added (EVA) and Financial Value Added (FVA) Economic Value Added was developed by Stern, Stewart & Company, while Financial Value...

  7. Development of mechanical properties in a CaO added AZ31 magnesium alloy processed by equal-channel angular pressing

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Seong-Hwan [Division of Materials Science and Engineering, Hanyang University, Seoul 133-791 (Korea, Republic of); Metal Forming Technology R& D Group, Korea Institute of Industrial Technology, Incheon 406-840 (Korea, Republic of); Jung, Ki Ho; Shin, Young-Chul; Yoon, Duk Jae [Metal Forming Technology R& D Group, Korea Institute of Industrial Technology, Incheon 406-840 (Korea, Republic of); Kawasaki, Megumi, E-mail: [Division of Materials Science and Engineering, Hanyang University, Seoul 133-791 (Korea, Republic of); Departments of Aerospace & Mechanical Engineering and Materials Science, University of Southern California, Los Angeles, CA 90089-1453 (United States)


    Processing through the application of equal-channel angular pressing (ECAP) is recognized as one of the attractive severe plastic deformation techniques where the processed bulk metals generally achieve ultrafine-grained microstructure leading to improved physical characteristics and mechanical properties. Magnesium has received much attention to date for its lightweight, high strength and excellent elasticity. Mg alloys with addition of CaO is reported to provide the successful casting procedure without usage of greenhouse gas, SF{sub 6}, whereas it is generally used for preventing the oxidation of Mg during casting. In the present investigation, a CaO added AZ31 (AZ31-CaO) magnesium alloy was processed by ECAP at elevated temepratures with a few steps of reduction which result in significant grain refinement to ~ 1.5 μm after 6 passes. Compression testing at room temperature demonstrated the AZ31-CaO alloy after ECAP showed enhanced yield strength more than the as-processed commercial AZ31 alloy while both alloys maintained ductility in spite of significant reduction in grain size. The improved strength in the AZ31-CaO alloy was attributed to the formation of fine Al{sub 2}Ca precipitates which experience breaking-up through ECAP and accelerate the microstructural refinement. Moreover, the preservation of ductility was attributed to the enhancement of strain hardening capability in the AZ31 alloy at room temperature. This study discusses the feasibility of using ECAP to improve both strength and ductility on magnesium alloys by applying the diagram describing the paradox of strength and ductility. - Highlights: • AZ31 and AZ31-CaO magnesium alloys were processed by ECAP up to 6 passes. • AZ31-CaO alloy after ECAP showed improved yield strength without losing ductility. • CaO in AZ31 forms fine Al{sub 2}Ca accelerating microstructural refinement during ECAP. • Feasibility of using ECAP was shown to improve both strength and ductility in Mg.

  8. High dietary phosphorus density is a risk factor for incident chronic kidney disease development in diabetic subjects: a community-based prospective cohort study. (United States)

    Yoon, Chang-Yun; Park, Jung Tak; Jhee, Jong Hyun; Noh, Juhwan; Kee, Youn Kyung; Seo, Changhwan; Lee, Misol; Cha, Min-Uk; Kim, Hyoungnae; Park, Seohyun; Yun, Hae-Ryong; Jung, Su-Young; Han, Seung Hyeok; Yoo, Tae-Hyun; Kang, Shin-Wook


    Background: High serum phosphorus concentrations are associated with an increased risk of cardiovascular disease and progression of chronic kidney disease (CKD). However, the relation between dietary phosphorus intake and CKD development has not been well evaluated.Objective: In this study, we investigated the impact of dietary phosphorus density on the development of incident CKD in a cohort of subjects with normal renal function.Design: Data were retrieved from the Korean Genome and Epidemiology Study, a prospective community-based cohort study. The study cohort consisted of subjects aged 40-69 y, who were followed up biennially from 2001 to 2014. A total of 873 subjects with diabetes mellitus (DM) and 5846 subjects without DM (non-DM) were included in the final analysis. The primary endpoint was incident CKD, defined as a composite of estimated glomerular filtration rate phosphorus density, defined as the ratio of a single-day dietary phosphorus amount to the total daily calorie intake, were 0.51 ± 0.08 mg/kcal in the DM group and 0.51 ± 0.07 mg/kcal in the non-DM group. During the follow-up, CKD newly developed in 283 (32.4%) and 792 subjects (13.5%) in the DM and non-DM groups, respectively. When the subjects were divided into quartiles according to the dietary phosphorus density in each group, the highest quartile was significantly associated with the development of incident CKD by multiple Cox proportional hazard analysis in the DM group (P = 0.02) but not in the non-DM group (P = 0.72).Conclusions: High dietary phosphorus density is associated with an increased risk of CKD development in DM patients with normal renal function. The causality in this association needs to be tested in a randomized controlled trial. © 2017 American Society for Nutrition.

  9. Personality predictors of the development of elementary school children's intentions to drink alcohol: the mediating effects of attitudes and subjective norms. (United States)

    Hampson, Sarah E; Andrews, Judy A; Barckley, Maureen; Severson, Herbert H


    The authors tested a mediation model in which childhood hostility and sociability were expected to influence the development of intentions to use alcohol in the future through the mediating mechanisms of developing attitudes and norms. Children in 1st through 5th grades (N=1,049) from a western Oregon community participated in a longitudinal study involving 4 annual assessments. Hostility and sociability were assessed by teachers' ratings at the 1st assessment, and attitudes, subjective norms, and intentions were assessed by self-report at all 4 assessments. For both genders, latent growth modeling demonstrated that sociability predicted an increase in intentions to use alcohol over time, whereas hostility predicted initial levels of these intentions. These personality effects were mediated by the development of attitudes and subjective norms, supporting a model wherein childhood personality traits exert their influence on the development of intentions to use alcohol through the development of these more proximal cognitions. ((c) 2006 APA, all rights reserved).

  10. Value Added in English Schools (United States)

    Ray, Andrew; McCormack, Tanya; Evans, Helen


    Value-added indicators are now a central part of school accountability in England, and value-added information is routinely used in school improvement at both the national and the local levels. This article describes the value-added models that are being used in the academic year 2007-8 by schools, parents, school inspectors, and other…

  11. Mobile Offloading in Wireless Ad Hoc Networks


    Kalejaiye, Gabriel B. T.; Rondina, João A. S. R.; Albuquerque, Leonardo V. V. L.; Pereira, Taís L.; Campos, Luiz F. O.; Melo, Raphael A. S.; Mascarenhas, Daniel S.; Carvalho, Marcelo M.


    This paper describes a strategy that was designed, implemented, and presented at the {\\it Mobile Ad Hoc Networking Interoperability and Cooperation (MANIAC) Challenge 2013}. The theme of the MANIAC Challenge 2013 was ``Mobile Data Offloading,'' and consisted on developing and comparatively evaluating strategies to offload infrastructure access points via customer ad hoc forwarding using handheld devices (e.g., tablets and smartphones). According to the challenge rules, a hop-by-hop bidding co...

  12. The development of heat exchangers with advanced thermomechanical materials; Sviluppi e prospettive degli scambiatori di calore ceramici per l`impiantistica energetica ad alta temperatura

    Energy Technology Data Exchange (ETDEWEB)

    Capra, Marcello [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dipt. Energia


    Current metallurgical limitations necessarily impose a number of restrictions on the efficiency of power plant and combustion systems. These limitations include both temperature and corrosion resistance. If significant improvements can be made in these areas, then not only will it be possible to obtain higher system efficiencies, but it will also be possible to further exploit new technologies. Consequently, there is appreciable interest in the development of ceramic tubes for heat exchangers. Such tubes would offer the potential of operation at much higher temperatures combined with a much improved resistance to chemical attack. They are unlikely to be suitable for high pressure operation, at least in the foreseeable future, and hence their use would be limited generally to gas to gas exchangers. In spite of the limitations on details and specific technological solutions imposed by industrial property conditions, this report provides an overview on the development of these components, which is in charge of all the major international industrial companies of the field, in consideration of the relevant benefits coming from their large industrialization. After an analysis of the industrial situation of the product, in terms both of possible applications and economical impacts on the market, an overview of major on-going R and D programmes is carried out. At present, these programmes are mostly within the general frame of the study of advanced thermomechanical components and the related manufacturing technologies development.

  13. AdS Black Hole with Phantom Scalar Field

    Directory of Open Access Journals (Sweden)

    Limei Zhang


    Full Text Available We present an AdS black hole solution with Ricci flat horizon in Einstein-phantom scalar theory. The phantom scalar fields just depend on the transverse coordinates x and y, which are parameterized by the parameter α. We study the thermodynamics of the AdS phantom black hole. Although its horizon is a Ricci flat Euclidean space, we find that the thermodynamical properties of the black hole solution are qualitatively the same as those of AdS Schwarzschild black hole. Namely, there exists a minimal temperature and the large black hole is thermodynamically stable, while the smaller one is unstable, so there is a so-called Hawking-Page phase transition between the large black hole and the thermal gas solution in the AdS space-time in Poincare coordinates. We also calculate the entanglement entropy for a strip geometry dual to the AdS phantom black holes and find that the behavior of the entanglement entropy is qualitatively the same as that of the black hole thermodynamical entropy.

  14. Development of Meta-Subject Competencies of the 7-9 Grades Basic School Students through the Implementation of Interdisciplinary Mathematical Courses (United States)

    Gorev, Pavel M.; Masalimova, Alfiya R.


    The article is aimed at describing one of the possible interdisciplinary courses for students of the 7-9 classes of the basic school connecting mathematics with natural sciences and the study of such courses role in the formation and development of meta-subject competencies of students. The leading method for this is the modeling of…

  15. Increased Risk of Diabetes Development in Subjects with the Hypertriglyceridemic Waist Phenotype: A 4-Year Longitudinal Study

    Directory of Open Access Journals (Sweden)

    Ki Joong Han


    Full Text Available BackgroundThe hypertriglyceridemic waist (HTGW phenotype is a simple and inexpensive screening parameter to identify people at increased risk of cardiovascular disease. We evaluated whether the HTGW phenotype predicts diabetes in urban Korean adults.MethodsA total of 2,900 nondiabetic subjects (mean age 44.3 years, comprising 2,078 males (71.7% and 822 females (28.3% who underwent annual medical check-ups at our center between January 2005 and December 2009, were recruited. The subjects were divided into four groups according to baseline serum triglyceride (TG level and waist circumference (WC: normal WC-normal TG (NWNT level, normal WC-high TG level, enlarged WC-normal TG level, and enlarged WC-high TG (EWHT level. High serum TG level was defined as ≥150 mg/dL and enlarged WC was defined as ≥90 cm for men and ≥85 cm for women. New cases of diabetes were determined according to questionnaires filled in by participants and the diagnostic criteria of the American Diabetes Association. Cox proportional hazards model analysis was used to assess the association of HTGW phenotype with the incidence of diabetes.ResultsA total of 101 (3.5% new diabetes cases were diagnosed during the study period. The EWHT group had a higher incidence of diabetes (8.3% compared with the NWNT group (2.2%. The adjusted hazard ratio for diabetes for subjects with the EWHT phenotype at baseline was 4.113 (95% confidence interval [CI], 2.397 to 7.059 after adjustment for age, and 2.429 (95% CI, 1.370 to 4.307 after adjustment for age, sex, total cholesterol, systolic blood pressure, and alcohol drinking history. It was attenuated by inclusion of baseline fasting glucose level in the model.ConclusionSubjects with the HTGW phenotype showed the highest risk of incident diabetes. This tool could be useful for identifying individuals at high risk of diabetes.

  16. Data package for the Low-Level Waste Disposal Development and Demonstration Program environmental impact statement: Volume 1, Sections 1--7 and Appendices A--D

    Energy Technology Data Exchange (ETDEWEB)

    Ketelle, R.H.


    This data package is required to support an Environmental Impact Statement (EIS) to be written to evaluate the effects of future disposal of low-level waste at four sites on the Oak Ridge Reservation. Current waste disposal facilities are exceeding their capacities and increasingly stringent disposal requirements dictate the need for the sites and new waste disposal technologies. The Low-Level Waste Disposal Development and Demonstration Program has developed a strategy for low-level waste disposal built around a dose based approach. This approach emphasizes contamination pathways, including surface and groundwater and ALARA conditions for workers. This strategy dictates the types of data needed for this data package. The data package provides information on geology, soils, groundwater, surface water, and ecological characterization of the Oak Ridge Reservation in order to evaluate alternative technologies and alternative sites. The results of the investigations and data collections indicate that different technologies will probably have to be used at different sites. This conclusion, however, depends on the findings of the Environmental Impact Statement. 14 figs., 19 tabs.

  17. 17 CFR 240.17Ad-14 - Tender agents. (United States)


    ... Section 240.17Ad-14 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED... Exchange Act of 1934 Supervised Investment Bank Holding Company Rules § 240.17Ad-14 Tender agents. (a) Establishing book-entry depository accounts. When securities of a subject company have been declared eligible...


    Directory of Open Access Journals (Sweden)

    Xuesong FENG, Ph.D Candidate


    Full Text Available It is expected that improvement of transport networks could give rise to the change of spatial distributions of population-related factors and car ownership, which are expected to further influence travel demand. To properly reflect such an interdependence mechanism, an aggregate multinomial logit (A-MNL model was firstly applied to represent the spatial distributions of these exogenous variables of the travel demand model by reflecting the influence of transport networks. Next, the spatial autocorrelation analysis is introduced into the log-transformed A-MNL model (called SPA-MNL model. Thereafter, the SPA-MNL model is integrated into the four-step travel demand model with feedback (called 4-STEP model. As a result, an integrated travel demand model is newly developed and named as the SPA-STEP model. Using person trip data collected in Beijing, the performance of the SPA-STEP model is empirically compared with the 4-STEP model. It was proven that the SPA-STEP model is superior to the 4-STEP model in accuracy; most of the estimated parameters showed statistical differences in values. Moreover, though the results of the simulations to the same set of assumed scenarios by the 4-STEP model and the SPA-STEP model consistently suggested the same sustainable path for the future development of Beijing, it was found that the environmental sustainability and the traffic congestion for these scenarios were generally overestimated by the 4-STEP model compared with the corresponding analyses by the SPA-STEP model. Such differences were clearly generated by the introduction of the new modeling step with spatial autocorrelation.

  19. Adding timing to the VELO

    CERN Document Server

    Mitreska, Biljana


    The LHCb experiment is designed to perform high precision measurements of matter-antimatter asymmetries and searches for rare and forbidden decays, with the aim of discovering new and unexpected particles and forces. In 2030 the LHC beam intensity will increase by a factor of 50 compared to current operations. This means increased samples of the particles we need to study, but it also presents experimental challenges. In particular, with current technology it becomes impossible to differentiate the many (>50) separate proton-proton collisions which occur for each bunch crossing.\\\\ In this project a Monte Carlo simulation was developed to model the operation of a silicon pixel vertex detector surrounding the collision region at LHCb, under the conditions expected after 2030, after the second upgrade of the Vertex Locator(VELO).The main goal was studying the effect of adding '4D' detectors which save high-precision timing information, in addition to the usual three spatial coordinates, as charged particles pas...

  20. Revisiting the thermodynamic relations in AdS /CMT models (United States)

    Hyun, Seungjoon; Park, Sang-A.; Yi, Sang-Heon


    Motivated by the recent unified approach to the Smarr-like relation of anti-de Sitter (AdS) planar black holes in conjunction with the quasilocal formalism on conserved charges, we revisit the quantum statistical and thermodynamic relations of hairy AdS planar black holes. By extending the previous results, we identify the hairy contribution in the bulk and show that the holographic computation can be improved so that it is consistent with the bulk computation. We argue that the first law can be retained in its universal form and that the relation between the on-shell renormalized Euclidean action and its free energy interpretation in gravity may also be undeformed even with the hairy contribution in hairy AdS black holes.

  1. Asymptotically AdS spacetimes with a timelike Kasner singularity

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Jie [Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel)


    Exact solutions to Einstein’s equations for holographic models are presented and studied. The IR geometry has a timelike cousin of the Kasner singularity, which is the less generic case of the BKL (Belinski-Khalatnikov-Lifshitz) singularity, and the UV is asymptotically AdS. This solution describes a holographic RG flow between them. The solution’s appearance is an interpolation between the planar AdS black hole and the AdS soliton. The causality constraint is always satisfied. The entanglement entropy and Wilson loops are discussed. The boundary condition for the current-current correlation function and the Laplacian in the IR is examined. There is no infalling wave in the IR, but instead, there is a normalizable solution in the IR. In a special case, a hyperscaling-violating geometry is obtained after a dimensional reduction.


    Indian Academy of Sciences (India)

    Subject Index. Variation of surface electric field during geomagnetic disturbed period at Maitri, Antarctica. 1721. Geomorphology. A simple depression-filling method for raster and irregular elevation datasets. 1653. Decision Support System integrated with Geographic. Information System to target restoration actions in water-.

  3. Development of a nopal fiber (Opuntia ficus-indica and powdered cocoa (Theobroma cacao added beef patties, nutritive, physicochemical and sensory characteristics

    Directory of Open Access Journals (Sweden)

    F.H. Chamorro-Ramirez


    Full Text Available The objective of this work was to evaluate addition effect of 3% of nopal fiber (FN and cacao powder (CA on the physicochemical, nutritional content and sensory acceptation of patty meat. A total of 144 patties were elaborated in three different batches: Control (TC no addition; FN with 3% of FN; and CA with 3% of CA. Physicochemical tests (pH, Aw, texture (TPA and instrumental color (CIE-Lab at different storage times (0, 2, 7, 14 and 28 days, besides to nutritional content and acceptation test. pH increased in all the treatments at 28 days of storage, where CA addition decreased luminosity (P>0.05 and maintained higher a* values (P0.05. FN or CA addition increased fiber content (P<0.05. Patties with FN showed a moderate acceptation. Since addition of FN or CA did not decreased consumer acceptation, these can be employed as ingredients in the development of functional foods.

  4. Incorporation of Inter-Subject Information to Improve the Accuracy of Subject-Specific P300 Classifiers. (United States)

    Xu, Minpeng; Liu, Jing; Chen, Long; Qi, Hongzhi; He, Feng; Zhou, Peng; Wan, Baikun; Ming, Dong


    Although the inter-subject information has been demonstrated to be effective for a rapid calibration of the P300-based brain-computer interface (BCI), it has never been comprehensively tested to find if the incorporation of heterogeneous data could enhance the accuracy. This study aims to improve the subject-specific P300 classifier by adding other subject's data. A classifier calibration strategy, weighted ensemble learning generic information (WELGI), was developed, in which elementary classifiers were constructed by using both the intra- and inter-subject information and then integrated into a strong classifier with a weight assessment. 55 subjects were recruited to spell 20 characters offline using the conventional P300-based BCI, i.e. the P300-speller. Four different metrics, the P300 accuracy and precision, the round accuracy, and the character accuracy, were performed for a comprehensive investigation. The results revealed that the classifier constructed on the training dataset in combination with adding other subject's data was significantly superior to that without the inter-subject information. Therefore, the WELGI is an effective classifier calibration strategy which uses the inter-subject information to improve the accuracy of subject-specific P300 classifiers, and could also be applied to other BCI paradigms.

  5. Holography in Lovelock Chern-Simons AdS gravity (United States)

    Cvetković, Branislav; Miskovic, Olivera; Simić, Dejan


    We analyze holographic field theory dual to Lovelock Chern-Simons anti-de Sitter (AdS) gravity in higher dimensions using first order formalism. We first find asymptotic symmetries in the AdS sector showing that they consist of local translations, local Lorentz rotations, dilatations and non-Abelian gauge transformations. Then, we compute 1-point functions of energy-momentum and spin currents in a dual conformal field theory and write Ward identities. We find that the holographic theory possesses Weyl anomaly and also breaks non-Abelian gauge symmetry at the quantum level.

  6. AdS5 magnetized solutions in minimal gauged supergravity (United States)

    Blázquez-Salcedo, Jose Luis; Kunz, Jutta; Navarro-Lérida, Francisco; Radu, Eugen


    We construct a generalization of the AdS charged rotating black holes with two equal magnitude angular momenta in five-dimensional minimal gauged supergravity. In addition to the mass, electric charge and angular momentum, the new solutions possess an extra-parameter associated with a non-zero magnitude of the magnetic potential at infinity. In contrast with the known cases, these new black holes possess a non-trivial zero-horizon size limit which describes a one parameter family of spinning charged solitons. All configurations reported in this work approach asymptotically an AdS5 spacetime in global coordinates and are free of pathologies.

  7. AdS5 magnetized solutions in minimal gauged supergravity

    Directory of Open Access Journals (Sweden)

    Jose Luis Blázquez-Salcedo


    Full Text Available We construct a generalization of the AdS charged rotating black holes with two equal magnitude angular momenta in five-dimensional minimal gauged supergravity. In addition to the mass, electric charge and angular momentum, the new solutions possess an extra-parameter associated with a non-zero magnitude of the magnetic potential at infinity. In contrast with the known cases, these new black holes possess a non-trivial zero-horizon size limit which describes a one parameter family of spinning charged solitons. All configurations reported in this work approach asymptotically an AdS5 spacetime in global coordinates and are free of pathologies.

  8. Loops in AdS from conformal field theory (United States)

    Aharony, Ofer; Alday, Luis F.; Bissi, Agnese; Perlmutter, Eric


    We propose and demonstrate a new use for conformal field theory (CFT) crossing equations in the context of AdS/CFT: the computation of loop amplitudes in AdS, dual to non-planar correlators in holographic CFTs. Loops in AdS are largely unexplored, mostly due to technical difficulties in direct calculations. We revisit this problem, and the dual 1 /N expansion of CFTs, in two independent ways. The first is to show how to explicitly solve the crossing equations to the first subleading order in 1 /N 2, given a leading order solution. This is done as a systematic expansion in inverse powers of the spin, to all orders. These expansions can be resummed, leading to the CFT data for finite values of the spin. Our second approach involves Mellin space. We show how the polar part of the four-point, loop-level Mellin amplitudes can be fully reconstructed from the leading-order data. The anomalous dimensions computed with both methods agree. In the case of ϕ 4 theory in AdS, our crossing solution reproduces a previous computation of the one-loop bubble diagram. We can go further, deriving the four-point scalar triangle diagram in AdS, which had never been computed. In the process, we show how to analytically derive anomalous dimensions from Mellin amplitudes with an infinite series of poles, and discuss applications to more complicated cases such as the N = 4 super-Yang-Mills theory.

  9. From mild cognitive impairment to subjective cognitive decline: conceptual and methodological evolution

    Directory of Open Access Journals (Sweden)

    Cheng YW


    Full Text Available Yu-Wen Cheng,1 Ta-Fu Chen,2 Ming-Jang Chiu2,3 1Department of Neurology, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan; 2Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; 3Department of Psychology, College of Science, National Taiwan University, Taipei, Taiwan Abstract: Identification of subjects at the early stages of Alzheimer’s disease (AD is fundamental for drug development and possible intervention or prevention of cognitive decline. The concept of mild cognitive impairment (MCI evolved during the past two decades to define subjects at the transitional stage between normal aging and dementia. Evidence from cross-sectional and longitudinal studies has shown that MCI is associated with an increased risk of positive AD biomarkers and an increased annual conversion rate of 5%–17% to AD. The presence of AD biomarkers in subjects with MCI was associated with an even higher risk of progression to dementia. However, earlier clinical trials for pharmacotherapy in subjects with MCI were disappointing. To extend the spectrum of AD to an earlier stage before MCI, subjective cognitive decline (SCD was introduced and was defined as self-reported cognitive decline before the deficits could be detected by cognitive tests. Subjects with SCD have an increased risk of underlying AD pathology. However, SCD can also develop secondary to other heterogeneous etiologies, including other neurodegenerative and psychiatric diseases, personality traits, physical conditions, and medication use. Several clinical and biomarker features were proposed to predict risk of conversion to AD in subjects with SCD. Further longitudinal studies are needed to support the validity of these high-risk features. Keywords: mild cognitive impairment, subjective cognitive decline, preclinical Alzheimer’s disease, Alzheimer’s disease

  10. The structural changes of upper airway and newly developed sleep breathing disorders after surgical treatment in class III malocclusion subjects. (United States)

    Lee, Ui Lyong; Oh, Hoon; Min, Sang Ki; Shin, Ji Ho; Kang, Yong Seok; Lee, Won Wook; Han, Young Eun; Choi, Young Jun; Kim, Hyun Jik


    Bimaxillary surgery is the traditional treatment of choice for correcting class III malocclusion which is reported to cause an alteration of oropharyngeal structures and upper airway narrowing that might be a predisposing factor for obstructive sleep apnea (OSA). This study aimed to analyze sleep parameters in class III malocclusion subjects and ascertain the prevalence of snoring or OSA following bimaxillary surgery.A total of 22 patients with Le Fort I osteotomy and mandibular setback for class III malocclusion were prospectively enrolled. All patients received endoscopic examination, cephalometry, 3-dimensional computed tomography (3D-CT), and sleep study twice at 1 month before and 3 months after surgery.The patient population consisted of 5 males and 17 females with a mean body mass index of 22.5 kg/m and mean age of 22.1 years. No patients complained of sleep-related symptoms, and the results of sleep study showed normal values before surgery. Three patients (13%) were newly diagnosed with mild or moderate OSA and 6 patients (27%) showed increased loudness of snoring (over 40 dB) after bimaxillary surgery. According to cephalometric analysis and 3D-CT results, the retropalatal and retroglossal areas were significantly narrowed in class III malocclusion patients, showing snoring and sleep apnea after surgery. In addition, the total volume of the upper airway was considerably reduced following surgery in the same patients.Postoperative narrowing of the upper airway and a reduction of total upper airway volume can be induced, and causes snoring and OSA in class III malocclusion subjects following bimaxillary surgery.

  11. Finding consistent strain distributions in the glenohumeral capsule between two subjects: implications for development of physical examinations. (United States)

    Drury, Nicholas J; Ellis, Benjamin J; Weiss, Jeffrey A; McMahon, Patrick J; Debski, Richard E


    The anterior-inferior glenohumeral capsule is the primary passive stabilizer to the glenohumeral joint during anterior dislocation. Physical examinations following dislocation are crucial for proper diagnosis of capsule pathology; however, they are not standardized for joint position which may lead to misdiagnoses and poor outcomes. To suggest joint positions for physical examinations where the stability provided by the capsule may be consistent among patients, the objective of this study was to evaluate the distribution of maximum principal strain on the anterior-inferior capsule using two validated subject-specific finite element models of the glenohumeral joint at clinically relevant joint positions. The joint positions with 25 N anterior load applied at 60° of glenohumeral abduction and 10°, 20°, 30° and 40° of external rotation resulted in distributions of strain that were similar between shoulders (r² ≥ 0.7). Furthermore, those positions with 20-40° of external rotation resulted in capsule strains on the glenoid side of the anterior band of the inferior glenohumeral ligament that were significantly greater than in all other capsule regions. These findings suggest that anterior stability provided by the anterior-inferior capsule may be consistent among subjects at joint positions with 60° of glenohumeral abduction and a mid-range (20-40°) of external rotation, and that the glenoid side has the greatest contribution to stability at these joint positions. Therefore, it may be possible to establish standard joint positions for physical examinations that clinicians can use to effectively diagnose pathology in the anterior-inferior capsule following dislocation and lead to improved outcomes. Copyright © 2010 Elsevier Ltd. All rights reserved.

  12. Can adding web-based support to UK primary care exercise referral schemes improve patients’ physical activity levels? Intervention development for the e-coachER study.

    Directory of Open Access Journals (Sweden)

    Adrian Taylor


    Aims: This presentation will provide details on the intervention development and data to be captured to inform a process evaluation. Methods: An initial version of e-coachER was produced, building on experiences from obesity and diabetes self-management interventions using the Lifeguide platform, and beta tested over 7 months. Co-applicants and researchers then provided feedback on a time-truncated version, and ERS patients on a real-time version, for 5 months before it was locked for the RCT. Within the trial, after participants are screened, provide consent and complete baseline assessments, they are randomised to receive usual ERS at each site or usual ERS plus a mailed Welcome Pack (including a user friendly guide to register for e-coachER access in-line, a free pedometer and a fridge magnet with daily recording strips for step counts or minutes of MVPA. Contact details for an e-coachER facilitator are provided for additional technical support. Results: At the core of the intervention are ‘7 Steps to Health’ aimed to last 5-10 mins each, to encourage patients to think about the benefits of PA, seek support from an ERS practitioner (and friends/family, and the web, to self-monitor PA with a pedometer and upload steps or minutes of MVPA, set progressive goals, build confidence, autonomy and relatedness (from Self-Determination Theory, find ways to increase sustainable PA more broadly, and deal with setbacks. An avatar (to avoid having to represent a range of individual characteristics such as age, gender, and ethnicity and brief narratives are used throughout to normalise and support behaviour change and encourage e-coachER use. Automatic or patient chosen e-mails from the Lifeguide system promote on-going use of functions such as recording weekly PA and goal setting. For each site, participants are able to access links to reputable generic websites for further information about chronic conditions and lifestyle, links to other sites and apps for self

  13. Crystals’ added value

    CERN Multimedia

    Antonella Del Rosso


    We are becoming used to the many applications that physics transfers to society. They span from vacuum techniques to electronics, and, of course, medicine and biophysics. The EU-supported PICOSEC project, of which CERN is the coordinator, goes beyond the simple spin-off technology and opens the doors of state-of-the-art crystal research to 22 researchers for applications that include calorimetry but also the next generation PET scanners.     Prototypes of crystal matrices developed for medical imaging projects.   The keyword is “multidisciplinary approach”. Developing new detectors for implementation in high-energy physics experiments but also in medical instrumentation requires a very diverse mixture of skills and competencies. Such a mixture does not necessarily come from a specific university faculty but rather from targeted training opportunities that are designed by several stakeholders, each one contributing with its own specificity. The PICOS...

  14. Development of Robust Behaviour Recognition for an at-Home Biomonitoring Robot with Assistance of Subject Localization and Enhanced Visual Tracking

    Directory of Open Access Journals (Sweden)

    Nevrez Imamoglu


    Full Text Available Our research is focused on the development of an at-home health care biomonitoring mobile robot for the people in demand. Main task of the robot is to detect and track a designated subject while recognizing his/her activity for analysis and to provide warning in an emergency. In order to push forward the system towards its real application, in this study, we tested the robustness of the robot system with several major environment changes, control parameter changes, and subject variation. First, an improved color tracker was analyzed to find out the limitations and constraints of the robot visual tracking considering the suitable illumination values and tracking distance intervals. Then, regarding subject safety and continuous robot based subject tracking, various control parameters were tested on different layouts in a room. Finally, the main objective of the system is to find out walking activities for different patterns for further analysis. Therefore, we proposed a fast, simple, and person specific new activity recognition model by making full use of localization information, which is robust to partial occlusion. The proposed activity recognition algorithm was tested on different walking patterns with different subjects, and the results showed high recognition accuracy.

  15. Black Hole Astrophysics in AdS Braneworlds

    CERN Document Server

    Emparan, R; Kaloper, Nemanja; Emparan, Roberto; Garcia-Bellido, Juan; Kaloper, Nemanja


    We consider astrophysics of large black holes localized on the brane in the infinite Randall-Sundrum model. Using their description in terms of a conformal field theory (CFT) coupled to gravity, deduced in Ref. [1], we show that they undergo a period of rapid decay via Hawking radiation of CFT modes. For example, a black hole of mass ${\\rm few} \\times M_\\odot$ would shed most of its mass in $\\sim 10^4 - 10^5$ years if the AdS radius is $L \\sim 10^{-1}$ mm, currently the upper bound from table-top experiments. Since this is within the mass range of X-ray binary systems containing a black hole, the evaporation enhanced by the hidden sector CFT modes could cause the disappearance of X-ray sources on the sky. This would be a striking signature of RS2 with a large AdS radius. Alternatively, for shorter AdS radii, the evaporation would be slower. In such cases, the persistence of X-ray binaries with black holes already implies an upper bound on the AdS radius of $L \\la 10^{-2}$ mm, an order of magnitude better than...

  16. Logarithmic AdS waves and Zwei-Dreibein gravity

    NARCIS (Netherlands)

    Bergshoeff, Eric A.; Goya, Andres F.; Merbis, Wout; Rosseel, Jan


    We show that the parameter space of Zwei-Dreibein Gravity (ZDG) in AdS(3) exhibits critical points, where massive graviton modes coincide with pure gauge modes and new 'logarithmic' modes appear, similar to what happens in New Massive Gravity. The existence of critical points is shown both at the

  17. Internet Advertising. Google AdWords versus Facebook Ads


    Paul PAŞCU


    This article describes how to use the applications for Internet advertising, Google AdWords and Facebook Ads. Our attempt is to present the advantages and disadvantages of each of them, the costs and benefits, a useful aspect for companies that plan to start advertising campaigns on the Internet.

  18. Internet Advertising. Google AdWords versus Facebook Ads

    Directory of Open Access Journals (Sweden)

    Paul PAŞCU


    Full Text Available This article describes how to use the applications for Internet advertising, Google AdWords and Facebook Ads. Our attempt is to present the advantages and disadvantages of each of them, the costs and benefits, a useful aspect for companies that plan to start advertising campaigns on the Internet.

  19. Effects of sugar-sweetened beverage intake on the development of type 2 diabetes mellitus in subjects with impaired glucose tolerance: the Mihama diabetes prevention study. (United States)

    Teshima, Nobuko; Shimo, Miho; Miyazawa, Kae; Konegawa, Sachi; Matsumoto, Aki; Onishi, Yuki; Sasaki, Ryoma; Suzuki, Toshinari; Yano, Yutaka; Matsumoto, Kazutaka; Yamada, Tomomi; Gabazza, Esteban Cesar; Takei, Yoshiyuki; Sumida, Yasuhiro


    In Japan, the incidence of type 2 diabetes mellitus (T2DM) is increasing for several reasons, including increased consumption of sugar-sweetened beverages (SSBs). However, whether SSBs cause T2DM by excess of energy production resulting in obesity remains unclear. Therefore, the present study was designed to evaluate the effects of SSB intake on the development of T2DM in subjects with impaired glucose tolerance (IGT). Ninety-three subjects (30 males and 63 females) with IGT aged 40-69 y and residing in the Mihama district (southern Mie Prefecture, Japan) were included in the study. The mean observational period was 3.6 y. All subjects underwent the 75-g oral glucose tolerance test (OGTT) and completed a lifestyle questionnaire survey related to SSB intake. OGTT results and SSB intake were evaluated before and after the observational period. In addition, the correlation between SSB intake and development of T2DM was investigated. Of the 93 subjects, 20 (21.5%) developed T2DM (T2DM group) and demonstrated a significantly high SSB intake compared with the group that did not develop the disease (non-T2DM group). The odds ratio for the incidence of T2DM based on SSB intake was 3.26 (95% confidence interval, 1.17-9.06). The body mass index (BMI; kg/m(2)) and the homeostasis model assessment for insulin resistance (HOMA-R) values was significantly higher in the T2DM group than in the non-T2DM group, while the insulinogenic indices were significantly lower in the former than in the latter group. The sum of insulin secretion levels during OGTT was not significantly different between groups. SSB intake correlated with the predisposition for developing T2DM, possibly by influencing body weight, insulin resistance, and the ability of the pancreatic beta cells to effectively compensate for the insulin resistance.

  20. Subjective meaning: an introduction

    NARCIS (Netherlands)

    van Wijnbergen-Huitink, Janneke; van Wijbergen-Huitink, Janneke; Meier, Cécile

    This introductory chapter traces some of the considerations on the basis of which relativistic approaches to subjective meaning became en vogue. In doing so, the chapter provides an overview of the relevant linguistic and philosophical issues when developing a treatment of subjectivity. In addition,

  1. Ethics in science education: responsabilities and commitments with the child's moral development in the discussion of controversial subjects

    Directory of Open Access Journals (Sweden)

    Júlio César Castilho Razera


    Full Text Available A review of recent research outcomes presents in a sample of Science Education journals, shows that ethics and moral development issues have been neglected in the Science Education research. Based in theoretical referential directed toward this theme, and in a research carried out on controversial issues in the Science Teaching, such as those related to the debate creationism versus evolutionism, this paper tries to show the necessity and possibilities to take into consideration questions of this nature in classroom, in order to help developing the moral in students.

  2. Direct implication of carbon monoxide in the development of heart failure in rats with cardiac hypertrophy subjected to air pollution. (United States)

    Melin, Alexandre; Bonnet, Pierre; Eder, Veronique; Antier, Daniel; Obert, Philippe; Fauchier, Laurent


    Pollution is known to particularly affect patients with respiratory insufficiency and right ventricle abnormalities. We therefore hypothesized that carbon monoxide (CO) at low dose could be involved in cardiovascular disorders in patients with chronic hypoxic pulmonary hypertension secondary to chronic hypoxia. Ten-week-old male and female healthy Dark Agouti rats were randomly divided into two series--untrained (U) and trained (T)--of four groups of 18 animals each. Both U and T series were continuously exposed to ambient air (U(AIR), and T(AIR); n = 16) or air plus 50 ppm CO (U(AIR+CO) and T(AIR+CO); n = 18). Similarly, rats initially subjected to right ventricle hypertrophy secondary to chronic hypoxia (H) were continuously exposed to ambient air (TH(AIR), and UH(AIR); n = 18) or air plus 50 ppm CO (UH(AIR+CO), and TH(AIR+CO); n = 18). Doppler-echocardiography and hemodynamic studies performed at rest both indi-cated that CO had no significant effect on cardiac morphology or functions in control rats (U(AIR+CO) vs U(AIR)). In contrast, cardiac dilation and large decreases in left ventricular ejection fraction, mitral early diastolic rapid inflow (E) deceleration, E/atrial contraction filling (A) ratio, +dP/dt, and -dP/dt were found in TH(AIR+CO) compared with TH(AIR). After exposure, heart rate variability was unaffected in U(AIR+CO), whereas total power spectra were markedly decreased and low frequency/high frequency power ratio was increased in TH(AIR+CO) rats. CO pollution could be directly involved in cardiac disorders of patients with pre-existent hypertrophic cardiomyopathies.

  3. The development of subjective quality of life over the first 2 years in first-episode psychosis

    DEFF Research Database (Denmark)

    Melle, Ingrid; Røssberg, Jan Ivar; Joa, Inge


    of variance were done to evaluate the development over time, and multiple linear regression analyses to evaluate predictors of change. These patients with a first-episode psychosis showed a significant improvement in general s-QoL during the first 2 years of treatment. Improvements in general s-QoL were...

  4. Cognitive and oculomotor performance in subjects with low and high schizotypy: implications for translational drug development studies. (United States)

    Koychev, I; Joyce, D; Barkus, E; Ettinger, U; Schmechtig, A; Dourish, C T; Dawson, G R; Craig, K J; Deakin, J F W


    The development of drugs to improve cognition in patients with schizophrenia is a major unmet clinical need. A number of promising compounds failed in recent clinical trials, a pattern linked to poor translation between preclinical and clinical stages of drug development. Seeking proof of efficacy in early Phase 1 studies in surrogate patient populations (for example, high schizotypy individuals where subtle cognitive impairment is present) has been suggested as a strategy to reduce attrition in the later stages of drug development. However, there is little agreement regarding the pattern of distribution of schizotypal features in the general population, creating uncertainty regarding the optimal control group that should be included in prospective trials. We aimed to address this question by comparing the performance of groups derived from the general population with low, average and high schizotypy scores over a range of cognitive and oculomotor tasks. We found that tasks dependent on frontal inhibitory mechanisms (N-Back working memory and anti-saccade oculomotor tasks), as well as a smooth-pursuit oculomotor task were sensitive to differences in the schizotypy phenotype. In these tasks the cognitive performance of 'low schizotypes' was significantly different from 'high schizotypes' with 'average schizotypes' having an intermediate performance. These results indicate that for evaluating putative cognition enhancers for treating schizophrenia in early-drug development studies the maximum schizotypy effect would be achieved using a design that compares low and high schizotypes.


    Directory of Open Access Journals (Sweden)

    Pavel E. Shenderey


    Full Text Available Modern researches show that intersubject communications atinitial stages of their inclusion in cognitive activity of studentsplay a role of the situational starting, inducing incentive. The knowledge gained by students as a result of the previousexperience of assimilation of intersubject communicationsbecomes regulators of its informa-tive activity at any stage ofinclusion of intersubject communications in cognitive activityand developments of research competence.

  6. Development of a minimum protocol for assessment in the paediatric voice clinic. Part 2: subjective measurement of symptoms of voice disorder. (United States)

    Cohen, Wendy; Wardrop, Amanda; Wynne, David McGregor; Kubba, Haytham; McCartney, Elspeth


    The European Laryngological Society (ELS) recommend that functional assessment of voice disorder in adults requires evaluation of a number of different parameters. These include perceptual evaluation of voice, videostroboscopic imaging of vocal fold movement, acoustic analysis of specific voicing aspects, aerodynamic support for voicing, and a subjective rating of voice impact. No specific guidelines are available for children, but a similar range of parameters is needed to guide intervention and measure outcomes. The development of subjective voice measures for adults and their adaptations for the paediatric population are reviewed and compared to the research comparing these to evaluation of vocal function. The need for further refinement of child assessment measures, and a proposal of how these might be developed, is discussed.

  7. Training-induced changes in muscle CSA, muscle strength, EMG, and rate of force development in elderly subjects after long-term unilateral disuse

    DEFF Research Database (Denmark)

    Suetta, Charlotte; Aagaard, Per; Rosted, Anna


    The ability to develop muscle force rapidly may be a very important factor to prevent a fall and to perform other tasks of daily life. However, information is still lacking on the range of training-induced neuromuscular adaptations in elderly humans recovering from a period of disuse. Therefore......, the present study examined the effect of three types of training regimes after unilateral prolonged disuse and subsequent hip-replacement surgery on maximal muscle strength, rapid muscle force [rate of force development (RFD)], muscle activation, and muscle size. Thirty-six subjects (60-86 yr) were randomized...... to a 12-wk rehabilitation program consisting of either 1) strength training (3 times/wk for 12 wk), 2) electrical muscle stimulation (1 h/day for 12 wk), or 3) standard rehabilitation (1 h/day for 12 wk). The nonoperated side did not receive any intervention and thereby served as a within-subject control...

  8. Using virtual reality to distinguish subjects with multiple- but not single-domain amnestic mild cognitive impairment from normal elderly subjects. (United States)

    Mohammadi, Alireza; Kargar, Mahmoud; Hesami, Ehsan


    Spatial disorientation is a hallmark of amnestic mild cognitive impairment (aMCI) and Alzheimer's disease. Our aim was to use virtual reality to determine the allocentric and egocentric memory deficits of subjects with single-domain aMCI (aMCIsd) and multiple-domain aMCI (aMCImd). For this purpose, we introduced an advanced virtual reality navigation task (VRNT) to distinguish these deficits in mild Alzheimer's disease (miAD), aMCIsd, and aMCImd. The VRNT performance of 110 subjects, including 20 with miAD, 30 with pure aMCIsd, 30 with pure aMCImd, and 30 cognitively normal controls was compared. Our newly developed VRNT consists of a virtual neighbourhood (allocentric memory) and virtual maze (egocentric memory). Verbal and visuospatial memory impairments were also examined with Rey Auditory-Verbal Learning Test and Rey-Osterrieth Complex Figure Test, respectively. We found that miAD and aMCImd subjects were impaired in both allocentric and egocentric memory, but aMCIsd subjects performed similarly to the normal controls on both tasks. The miAD, aMCImd, and aMCIsd subjects performed worse on finding the target or required more time in the virtual environment than the aMCImd, aMCIsd, and normal controls, respectively. Our findings indicated the aMCImd and miAD subjects, as well as the aMCIsd subjects, were more impaired in egocentric orientation than allocentric orientation. We concluded that VRNT can distinguish aMCImd subjects, but not aMCIsd subjects, from normal elderly subjects. The VRNT, along with the Rey Auditory-Verbal Learning Test and Rey-Osterrieth Complex Figure Test, can be used as a valid diagnostic tool for properly distinguishing different forms of aMCI. © 2018 Japanese Psychogeriatric Society.

  9. From objects to research subjects: contributions of childhood sociology to the development of an ethnography of indigenous peoples’ children education

    Directory of Open Access Journals (Sweden)

    Bárbara Elisa Pereira


    Full Text Available An ethnographic research with children requires the precision of the thick description of facts observed, such as those involving other social groups. Researches with children, however, are recent, especially considering the use of the preposition with, which means recognizing them as social actors and including them as active participants in the research process, possibilities opened up by the Childhood Sociology. Adopting this perspective, one seeks to develop a differentiated position in the research area, the atypical adult one (CORSARO, 1990; 2002; 2005; FERREIRA, 2008, in order to deepen the cultures of children, as the meanings closest to their worldview are investigated. The theoretic-methodological concepts developed by the studies on Childhood Sociology, their relations to the studies on Anthropology, and the ethnographic research with indigenous people’s children constitute the basis of this paper, whose aim is to reflect on the entry in the area and the adult’s position in researches with children.

  10. Culture-based Screening of Aerobic Microbiome in Diabetic Foot Subjects and Developing Non-Healing Ulcers

    Directory of Open Access Journals (Sweden)

    Saba Noor


    Full Text Available The study was carried on diabetic foot patients to deduce clinical attributes, the occurrence of the range of aerobic microbial flora and to assess their comparative in vitro susceptibility to the customarily used antimicrobials. We also studied the potential risk factors involved in the development of non-healing ulcers. A total of 87 organisms were isolated from 70 specimens, including Escherichia coli (19.5% among the Gram-negative and Staphylococcus aureus (18.4% among the Gram-positive as the predominant aerobes explored. Pseudomonas aeruginosa and Escherichia coli were predominant isolates of non-healing ulcers. The antimicrobial sensitivity pattern revealed that vancomycin (100% and amikacin (90.4% exhibited highest sensitivity to Gram-positive cocci, while all strains of Pseudomonas aeruginosa were sensitive towards imipenem (100%. The prevalent uncontrolled glycemic status, altered lipid spectra, the existence of neuropathy and peripheral vascular disease, suggested predisposition towards the development of non-healing lesions. The study has underlined the need for continuous surveillance of bacteria and their antimicrobial sensitivity blueprints to provide the basis for empirical therapy and to minimize the risk of complications. Further, stringent clinical evaluation and medical history will help in revealing the risk of developing non-healing status in diabetic foot ulcers.

  11. Culture-Based Screening of Aerobic Microbiome in Diabetic Foot Subjects and Developing Non-healing Ulcers. (United States)

    Noor, Saba; Ahmad, Jamal; Parwez, Iqbal; Ozair, Maaz


    The study was carried on diabetic foot patients to deduce clinical attributes, the occurrence of the range of aerobic microbial flora and to assess their comparative in vitro susceptibility to the customarily used antimicrobials. We also studied the potential risk factors involved in the development of non-healing ulcers. A total of 87 organisms were isolated from 70 specimens, including Escherichia coli (19.5%) among the Gram-negative and Staphylococcus aureus (18.4%) among the Gram-positive as the predominant aerobes explored. Pseudomonas aeruginosa and E. coli were predominant isolates of non-healing ulcers. The antimicrobial sensitivity pattern revealed that vancomycin (100%) and amikacin (90.4%) exhibited highest sensitivity to Gram-positive cocci, while all strains of P. aeruginosa were sensitive toward imipenem (100%). The prevalent uncontrolled glycemic status, altered lipid spectra, the existence of neuropathy, and peripheral vascular disease, suggested predisposition toward the development of non-healing lesions. The study has underlined the need for continuous surveillance of bacteria and their antimicrobial sensitivity blueprints to provide the basis for empirical therapy and to minimize the risk of complications. Further, stringent clinical evaluation, and medical history will help in revealing the risk of developing non-healing status in diabetic foot ulcers.

  12. Developing a Methodology for Eliciting Subjective Probability Estimates During Expert Evaluations of Safety Interventions: Application for Bayesian Belief Networks (United States)

    Wiegmann, Douglas A.a


    The NASA Aviation Safety Program (AvSP) has defined several products that will potentially modify airline and/or ATC operations, enhance aircraft systems, and improve the identification of potential hazardous situations within the National Airspace System (NAS). Consequently, there is a need to develop methods for evaluating the potential safety benefit of each of these intervention products so that resources can be effectively invested to produce the judgments to develop Bayesian Belief Networks (BBN's) that model the potential impact that specific interventions may have. Specifically, the present report summarizes methodologies for improving the elicitation of probability estimates during expert evaluations of AvSP products for use in BBN's. The work involved joint efforts between Professor James Luxhoj from Rutgers University and researchers at the University of Illinois. The Rutgers' project to develop BBN's received funding by NASA entitled "Probabilistic Decision Support for Evaluating Technology Insertion and Assessing Aviation Safety System Risk." The proposed project was funded separately but supported the existing Rutgers' program.

  13. The association between underweight and the development of albuminuria is different between sexes in relatively healthy Korean subjects. (United States)

    Jang, Cheol Min; Hyun, Young Youl; Lee, Kyu Beck; Kim, Hyang


    There are limited data on the association between underweight and albuminuria. The aim of this study is to verify the effect of underweight on the development of albuminuria. Participants who underwent two health check-ups with a 2-year interval at a tertiary hospital in Korea between 2002 and 2009 were studied. After exclusion of participants with estimated glomerular filtration rate (eGFR) albuminuria ≥1+ at the first check-up, 53 876 participants were enrolled. We measured the incidence of albuminuria at the second check-up and calculated the odds ratio (OR) for the development of albuminuria according to body mass index (BMI). After 2 years, 746 cases of incident albuminuria were observed among 53 876 participants. The effect of BMI on the development of albuminuria was modified by sex in a multivariate logistic model with adjustment for age, diabetes, hypertension, dyslipidaemia, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, uric acid, eGFR, current smoking status and alcohol intake (P-value for interaction albuminuria were 1.93 [95% confidence interval (CI), 1.35-2.76; P ≤ 0.001], 1.19 (0.84-1.67; P = 0.329) and 0.71 (0.43-1.17; P = 0.177) in underweight (BMI, albuminuria after 2 years in relatively healthy Korean females, but this relationship was not significant in males. This study suggests the need for more studies on the role of underweight in renal injury in men and women. © The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

  14. Vascoda and the Subject-based Gateways - the German Answer to Visibility and Accessibility in Collection Development

    Directory of Open Access Journals (Sweden)

    Klaus Kempf


    Full Text Available The „classic tasks“ of academic libraries comprise acquisition, cataloguing, reader services and preservation of literature or, more generally speaking, information resources. This has not changed radically in the digital age. What has changed, though, is the way the tasks are related to each other, perhaps also their respective importance (depending on the library type; but particularly the accentuation of certain aspects of the tasks mentioned above. Visibility and accessibility would hardly have been associated with collection development in the past. Holdings were entered in the catalogue and thus made ‘visible’. Accessibility was taken care of in the reader services department. This has changed significantly in the digital age. The reasons for that are manifold: · With the emergence of the so called ‘hybrid library’ the respective tasks of the central library functions have somewhat shifted and the previously rather clear-cut separations between them have become less rigid. · The innate ‘immateriality’ of digital resources requires a different approach to the topic of visibility and accessibility as early as the actual point of acquisition and in the presentation and ‘documentation’ of collection development. · Last but not least digital access points, next to the catalogue or OPAC including a large variety of different options (e.g. websites, have led to a much quicker and easier way of making holdings and particularly new acquisitions visible than would have been possible in the days of paper or card catalogues. But there are more basic reasons for the new way of dealing with visibility and accessibility. This is certainly due to the characteristics of collection development in the digital age which require us ‘acquisitions people’ to look at the question of visibility and accessibility from a different perspective and regard these as key aspects of the work we do.

  15. Patterns of regional brain activity in alcohol-dependent subjects. (United States)

    Hayden, Elizabeth P; Wiegand, Ryan E; Meyer, Eric T; Bauer, Lance O; O'connor, Sean J; Nurnberger, John I; Chorlian, David B; Porjesz, Bernice; Begleiter, Henri


    Electroencephalographic (EEG) measures of hemispheric asymmetry in anterior brain activity have been related to a variety of indices of psychopathology and emotionality. However, little is known about patterns of frontal asymmetry in alcohol-dependent (AD) samples. It is also unclear whether psychiatric comorbidity in AD subjects accounts for additional variance in frontal asymmetry, beyond a diagnosis of AD alone. We compared 193 AD subjects with 108 control subjects on resting brain activity in anterior and posterior regions, as indexed by asymmetries in alpha band power in the left and right hemispheres. Within the AD group alone, we examined whether comorbid major depressive disorder (MDD) or antisocial personality disorder (ASPD) had effects on regional asymmetry. Compared with control subjects, AD subjects exhibited lower left, relative to right, cortical activation in anterior regions. Evidence that comorbidity in AD subjects accounted for further variance in EEG asymmetry was mixed; AD subjects with comorbid ASPD were not significantly different from those without ASPD, while AD subjects with a lifetime history of MDD showed less asymmetry in anterior regions than those without MDD. Our findings indicate that AD subjects exhibit a pattern of frontal asymmetry similar to that found in other psychiatric groups. Results examining the effects of comorbidity in AD on EEG asymmetry were inconclusive. The implications of our findings for future work are described.

  16. AdS sub 2 supergravity and superconformal quantum mechanics

    CERN Document Server

    Astorino, M; Klemm, D; Zanon, D


    We investigate the asymptotic dynamics of topological anti-de Sitter supergravity in two dimensions. Starting from the formulation as a BF theory, it is shown that the AdS sub 2 boundary conditions imply that the asymptotic symmetries form a super-Virasoro algebra. Using the central charge of this algebra in Cardy's formula, we exactly reproduce the thermodynamical entropy of AdS sub 2 black holes. Furthermore, we show that the dynamics of the dilaton and its superpartner reduces to that of superconformal transformations that leave invariant one chiral component of the stress tensor supercurrent of a two-dimensional conformal field theory. This dynamics is governed by a supersymmetric extension of the de Alfaro-Fubini-Furlan model of conformal quantum mechanics. Finally, two-dimensional de Sitter gravity is also considered, and the dS sub 2 entropy is computed by counting CFT states.

  17. Entropy function and attractors for AdS black holes

    CERN Document Server

    Morales, J F; Morales, Jose F.; Samtleben, Henning


    We apply Sen's entropy formalism to the study of the near horizon geometry and the entropy of asymptotically AdS black holes in gauged supergravities. In particular, we consider non-supersymmetric electrically charged black holes with AdS_2 xS^{d-2} horizons in U(1)^4 and U(1)^3 gauged supergravities in d=4 and d=5 dimensions, respectively. We study several cases including static/rotating, BPS and non-BPS black holes in Einstein as well as in Gauss-Bonnet gravity. In all examples, the near horizon geometry and black hole entropy are derived by extremizing the entropy function and are given entirely in terms of the gauge coupling, the electric charges and the angular momentum of the black hole.

  18. AdS gravity and the scalar glueball spectrum

    Energy Technology Data Exchange (ETDEWEB)

    Vento, Vicente [Departament de Fisica Teorica, Universitat de Valencia y Institut de Fisica Corpuscular, Consejo Superior de Investigaciones Cientificas, Burjassot (Valencia) (Spain)


    The scalar glueball spectrum has attracted much attention since the formulation of Quantum Chromodynamics. Different approaches give very different results for the glueball masses. We revisit the problem from the perspective of the AdS/CFT correspondence. (orig.)

  19. The Mixed Phase of Charged AdS Black Holes

    Directory of Open Access Journals (Sweden)

    Piyabut Burikham


    Full Text Available We study the mixed phase of charged AdS black hole and radiation when the total energy is fixed below the threshold to produce a stable charged black hole branch. The coexistence conditions for the charged AdS black hole and radiation are derived for the generic case when radiation particles carry charge. The phase diagram of the mixed phase is demonstrated for both fixed potential and charge ensemble. In the dual gauge picture, they correspond to the mixed phase of quark-gluon plasma (QGP and hadron gas in the fixed chemical potential and density ensemble, respectively. In the nuclei and heavy-ion collisions at intermediate energies, the mixed phase of exotic QGP and hadron gas could be produced. The mixed phase will condense and evaporate into the hadron gas as the fireball expands.

  20. Conserved higher-spin charges in AdS4

    Directory of Open Access Journals (Sweden)

    O.A. Gelfond


    Full Text Available Gauge invariant conserved conformal currents built from massless fields of all spins in 4d Minkowski space–time and AdS4 are described in the unfolded dynamics approach. The current cohomology associated with non-zero conserved charges is found. The resulting list of charges is shown to match the space of parameters of the conformal higher-spin symmetry algebra in four dimensions.

  1. Generalised structures for N=1 AdS backgrounds

    Energy Technology Data Exchange (ETDEWEB)

    Coimbra, André [Institut für Theoretische Physik & Center for Quantum Engineering and Spacetime Research,Leibniz Universität Hannover,Appelstraße 2, 30167 Hannover (Germany); Strickland-Constable, Charles [Institut de physique théorique, Université Paris Saclay, CEA, CNRS, Orme des Merisiers, F-91191 Gif-sur-Yvette (France)


    We expand upon a claim made in a recent paper [] that generic minimally supersymmetric AdS backgrounds of warped flux compactifications of Type II and M theory can be understood as satisfying a straightforward weak integrability condition in the language of E{sub d(d)}×ℝ{sup +} generalised geometry. Namely, they are spaces admitting a generalised G-structure set by the Killing spinor and with constant singlet generalised intrinsic torsion.


    Directory of Open Access Journals (Sweden)

    Julián Andrés Rojas Meléndez


    Full Text Available The appropriation of the new technologies is a key aspect to maintain high competitiveness in a globalized economy for telecom carriers. The benefits provided by these new technologies allow them to easily adapt to the market conditions and to satisfy the changing needs of increasingly demanding users. One of these technologies is the JAIN SLEE specification, which presents a highly robust platform for rapid development and deployment of new value-added services. However the high degree of complexity of this technology limits the exploitation of its benefits and capabilities. In this paper, we propose a set of guidelines for value-added service development on JAIN SLEE environments based in the principles and guidelines for service creation defined in SOA, in order to facilitate this process.La apropiación de nuevas tecnologías por parte de los operadores de telecomunicaciones es un aspecto clave para mantener una alta competitividad en una economía globalizada. Los beneficios que proporcionan estas nuevas tecnologías les permiten a los operadores adaptarse fácilmente a las condiciones del mercado y satisfacer las necesidades cambiantes de usuarios, cada vez más exigentes. Una de estas tecnologías es la Especificación JAIN SLEE, la cual presenta una plataforma altamente robusta para el rápido desarrollo y despliegue de nuevos servicios de valor agregado. Sin embargo, el alto grado de complejidad de esta tecnología limita la explotación de sus beneficios y capacidades. En este artículo se propone una serie de lineamientos para el desarrollo de servicios de valor agregado en entornos JAIN SLEE basados en los principios y lineamientos para la creación de servicios definidos por SOA, de forma que se facilite este proceso.

  3. Classification of MR brain images by combination of multi-CNNs for AD diagnosis (United States)

    Cheng, Danni; Liu, Manhua; Fu, Jianliang; Wang, Yaping


    Alzheimer's disease (AD) is an irreversible neurodegenerative disorder with progressive impairment of memory and cognitive functions. Its early diagnosis is crucial for development of future treatment. Magnetic resonance images (MRI) play important role to help understand the brain anatomical changes related to AD. Conventional methods extract the hand-crafted features such as gray matter volumes and cortical thickness and train a classifier to distinguish AD from other groups. Different from these methods, this paper proposes to construct multiple deep 3D convolutional neural networks (3D-CNNs) to learn the various features from local brain images which are combined to make the final classification for AD diagnosis. First, a number of local image patches are extracted from the whole brain image and a 3D-CNN is built upon each local patch to transform the local image into more compact high-level features. Then, the upper convolution and fully connected layers are fine-tuned to combine the multiple 3D-CNNs for image classification. The proposed method can automatically learn the generic features from imaging data for classification. Our method is evaluated using T1-weighted structural MR brain images on 428 subjects including 199 AD patients and 229 normal controls (NC) from Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Experimental results show that the proposed method achieves an accuracy of 87.15% and an AUC (area under the ROC curve) of 92.26% for AD classification, demonstrating the promising classification performances.

  4. Added value: The differences that count

    Directory of Open Access Journals (Sweden)

    Dominique Bouchet


    Full Text Available Clinging to a simplistic conceptualization of the concept of added value might impair our capability to develop insights to what really matters today when companies seek to make differences within the global market. Today it is more necessary than ever to take into account the importance of language and culture as competitive factors.

  5. ADS Bumblebee comes of age (United States)

    Accomazzi, Alberto; Kurtz, Michael J.; Henneken, Edwin; Grant, Carolyn S.; Thompson, Donna M.; Chyla, Roman; McDonald, Steven; Shaulis, Taylor J.; Blanco-Cuaresma, Sergi; Shapurian, Golnaz; Hostetler, Timothy W.; Templeton, Matthew R.; Lockhart, Kelly E.


    The ADS Team has been working on a new system architecture and user interface named “ADS Bumblebee” since 2015. The new system presents many advantages over the traditional ADS interface and search engine (“ADS Classic”). A new, state of the art search engine features a number of new capabilities such as full-text search, advanced citation queries, filtering of results and scalable analytics for any search results. Its services are built on a cloud computing platform which can be easily scaled to match user demand. The Bumblebee user interface is a rich javascript application which leverages the features of the search engine and integrates a number of additional visualizations such as co-author and co-citation networks which provide a hierarchical view of research groups and research topics, respectively. Displays of paper analytics provide views of the basic article metrics (citations, reads, and age). All visualizations are interactive and provide ways to further refine search results. This new search system, which has been in beta for the past three years, has now matured to the point that it provides feature and content parity with ADS Classic, and has become the recommended way to access ADS content and services. Following a successful transition to Bumblebee, the use of ADS Classic will be discouraged starting in 2018 and phased out in 2019. You can access our new interface at

  6. Development and Initial Validation of a Multidimensional Scale Assessing Subjective Well-Being: The Well-Being Scale (WeBS). (United States)

    Lui, P Priscilla; Fernando, Gaithri A


    Numerous scales currently exist that assess well-being, but research on measures of well-being is still advancing. Conceptualization and measurement of subjective well-being have emphasized intrapsychic over psychosocial domains of optimal functioning, and disparate research on hedonic, eudaimonic, and psychological well-being lacks a unifying theoretical model. Lack of systematic investigations on the impact of culture on subjective well-being has also limited advancement of this field. The goals of this investigation were to (1) develop and validate a self-report measure, the Well-Being Scale (WeBS), that simultaneously assesses overall well-being and physical, financial, social, hedonic, and eudaimonic domains of this construct; (2) evaluate factor structures that underlie subjective well-being; and (3) examine the measure's psychometric properties. Three empirical studies were conducted to develop and validate the 29-item scale. The WeBS demonstrated an adequate five-factor structure in an exploratory structural equation model in Study 1. Confirmatory factor analyses showed that a bifactor structure best fit the WeBS data in Study 2 and Study 3. Overall WeBS scores and five domain-specific subscale scores demonstrated adequate to excellent internal consistency reliability and construct validity. Mean differences in overall well-being and its five subdomains are presented for different ethnic groups. The WeBS is a reliable and valid measure of multiple aspects of well-being that are considered important to different ethnocultural groups.

  7. Ad skepticisms: Antecedents and consequences

    Directory of Open Access Journals (Sweden)

    Rafique Ahmed


    Full Text Available Engaging customer is the burning issue for companies especially the service sector, either online or offline. Minimizing the customer disengagement is the same like reducing dissatisfaction or churn. Customer disengagement may be caused by many factors, ad skepticism is one of them; ad skepticism has two main antecedents personality variable and consumption/influencing varia-bles. This research explores the relationship of ad skepticism with customer disengagement through personality variables which are cynicism, reactance and self-esteem. The unit of analysis is the telecom and banking industry of Pakistan which is foreseeing an era of virtual currency and both are customer oriented industries. Only offline disengagement is researched and data is collected from the Business centers of telecom and banking branches dealing with virtual curren-cy in Pakistan. Hypothetical model is given after digging the relevant literature; model is tested through confirmatory factor analysis and structural equation modeling. Eight hypotheses were purposed from the connections of model, all hypotheses are accepted except the cynicism posi-tive effect on social ad skepticism. This can be due to commonality of social and charity in Paki-stani society, Muslims consider charity as a pious act and they do not think for cynic behavior in charity or social related works. The results manifest that customers in telecom industry are hav-ing ad skepticism and that is becoming the cause of their disengagement. Further, social ad skep-ticism has more impact on the customer disengagement than the general ad skepticism. While the reactance has more effect on general ad skepticism than other antecedents and cynicism has the lowest impact on social ad skepticism than other antecedents.

  8. Development of new diabetes risk scores on the basis of the current definition of diabetes in Japanese subjects [Rapid Communication]. (United States)

    Miyakoshi, Takahiro; Oka, Rie; Nakasone, Yasuto; Sato, Yuka; Yamauchi, Keishi; Hashikura, Rie; Takayama, Masayuki; Hirayama, Yudai; Hirabayashi, Kazuko; Koike, Hideo; Aizawa, Toru


    To develop diabetes risk score (RS) based on the current definition of diabetes, we retrospectively analyzed consecutive 4,159 health examinees who were non-diabetic at baseline. Diabetes, diagnosed by fasting plasma glucose (FPG) ≥7.0 mmol/L, 2hPG ≥11.1 mmol/L and/or HbA1c ≥6.5% (48 mmol/mol), developed in 279 of them during the mean period of 4.9 years. A full RS (RS Full ), a RS without 2hPG (RS -2hPG ) and a non-invasive RS (RS NI ) were created on the basis of multivariate Cox proportional model by weighted grading based on hazard ratio in half the persons assigned. The RSs were verified in the remaining half of the participants. Positive family history (FH), male sex, smoking and higher age, systolic blood pressure (SBP), FPG, 2hPG and HbA1c were independent predictors for RS Full . For RS -2hPG , 7 independent predictors, exclusive of 2hPG and smoking but inclusive of elevated triglycerides (TG) comparing to RS Full , were selected. FH, male sex, and higher age, SBP and HbA1c were independent predictors in RS NI . In the validation cohort, C-statistic (95%CI) of RS Full , RS -2hPG and RS NI were 0.80 (0.76-0.84), 0.75 (0.70-0.78) and 0.68 (0.63-0.72), respectively, which were significantly different from each other (P <0.01). Absolute percentage difference between predicted probability and observed diabetes were 1.9%, 0.7% and 0.9%, by the three scores, respectively, and not significantly different from each other. In conclusion, diabetes defined by the current criteria was predicted by the new diabetes risk scores with reasonable accuracy. Nonetheless, RS Full with a postchallenge glucose value performed superior to RS -2hPG and RS NI .

  9. Biomonitoring of coastal marine waters subject to anthropogenic use: development and application of the biosensor Mosselmonitor®

    Directory of Open Access Journals (Sweden)

    Barile Nadia B.


    Full Text Available The overall objective of this study was to develop a biological early warning system (Mosselmonitor® on offshore platform to detect critical environmental situations. The experiment was conducted on oil off-shore platform called Rospo Mare B. This structure is located in the area in front of Molise coast line (Italy, Adriatic Sea, characterized by a depth of about 77 m and a bathymetry between 65 and 80 m. The Mosselmonitor® works with eight mussels connected via specific sensors to PC for recording opening values of valves. A probe was installed inside the instrument to daily control of water pH, dissolved oxygen, salinity and temperature. Water samples are weekly analyzed for heavy metals, organochlorine pesticide and suspended matter. During the entire observation period, closure alarms were predominantly detected (99.9% and a decrease of 65% in alarms maximum duration was recorded from the fifth week. During the first month, none changes in water physico-chemical parameters were observed so that affect the bivalves behavior. The only chemical parameter steadily detected in water was copper; its average concentrations were of 10 ppb. Detected alarms were not comparable to those recorded in the first month: this observation could be explained considering that mussels will be adapted to copper constant presence.

  10. Development and validation of a numerical model of the swine head subjected to open-field blasts (United States)

    Kalra, A.; Zhu, F.; Feng, K.; Saif, T.; Kallakuri, S.; Jin, X.; Yang, K.; King, A.


    A finite element model of the head of a 55-kg Yucatan pig was developed to calculate the incident pressure and corresponding intracranial pressure due to the explosion of 8 lb (3.63 kg) of C4 at three different distances. The results from the model were validated by comparing findings with experimentally obtained data from five pigs at three different blast overpressure levels: low (150 kPa), medium (275 kPa), and high (400 kPa). The peak values of intracranial pressures from numerical model at different locations of the brain such as the frontal, central, left temporal, right temporal, parietal, and occipital regions were compared with experimental values. The model was able to predict the peak pressure with reasonable percentage differences. The differences for peak incident and intracranial pressure values between the simulation results and the experimental values were found to be less than 2.2 and 29.3%, respectively, at all locations other than the frontal region. Additionally, a series of parametric studies shows that the intracranial pressure was very sensitive to sensor locations, the presence of air bubbles, and reflections experienced during the experiments. Further efforts will be undertaken to correlate the different biomechanical response parameters, such as the intracranial pressure gradient, stress, and strain results obtained from the validated model with injured brain locations once the histology data become available.

  11. iAd Production Beginner's Guide

    CERN Document Server

    Collier, Ben


    This beginner's guide focuses on getting you through all the major learning points in a smooth, logical order. You'll also see how to avoid some common pitfalls. This book is for brands, advertisers and developers who want to create compelling, emotive, iAd advertisements that generate revenue and increase brand awareness. You don't need previous experience of creating adverts or apps for iPhone and iPad, as you'll be taken through the entire process to make motion-rich, beautiful ads.

  12. Introduction to AdS/CFT correspondence

    CERN Document Server

    Nastase, Horatiu


    Providing a pedagogical introduction to the rapidly developing field of AdS/CFT correspondence, this is one of the first texts to provide an accessible introduction to all the necessary concepts needed to engage with the methods, tools and applications of AdS/CFT. Without assuming anything beyond an introductory course in quantum field theory, it begins by guiding the reader through the basic concepts of field theory and gauge theory, general relativity, supersymmetry, supergravity, string theory and conformal field theory, before moving on to give a clear and rigorous account of AdS/CFT correspondence. The final section discusses the more specialised applications, including QCD, quark-gluon plasma and condensed matter. This book is self-contained and learner-focused, featuring numerous exercises and examples. It is essential reading for both students and researchers across the fields of particle, nuclear and condensed matter physics.

  13. Facilities Management and Value Adding - The LEGO case

    DEFF Research Database (Denmark)

    Jensen, Per Anker; Katchamart, Akarapong

    Purpose: To investigate how Facilities Management (FM) can add value and develop a management concept that can assist facilities managers in implementing value adding strategies and practices. Background: Earlier research has shown an increased focus on added value of FM and a FM Value Map has been...... developed to analyse and demonstrate the different ways FM can add value. However, there is a need to develop management tools that can be used more directly and proactively by facilities managers to implement adding value strategies and practices. Approach: The development of the concept is based...... example of how Value Adding Management can be implemented and added value measured. Practical Implications: The concept of Value Adding Management is expected to increase the awareness of the impacts and strategic importance of FM for organisations and can be a practical tool for facilities managers...

  14. International energy: Subject thesaurus supplement

    Energy Technology Data Exchange (ETDEWEB)



    This is a supplement to International Energy: Subject Thesaurus (ETDE/PUB--2(Rev.1)), which replaced DOE/TIC-7000--the EDB Subject Thesaurus. This supplement is provided periodically to keep International Energy: Subject Thesaurus recipients up-to-date on valid vocabulary terms (descriptors) used in building and maintaining several international energy information databases. Each issue contains all new terms added since the publication of the Thesaurus. Each supplement is a cumulative listing of the new terms, so that each issue replaces the previous one.

  15. ADS/CFT and QCD

    Energy Technology Data Exchange (ETDEWEB)

    Brodsky, Stanley J.; /SLAC; de Teramond, Guy F.; /Costa Rica U. /SLAC


    The AdS/CFT correspondence between string theory in AdS space and conformal .eld theories in physical spacetime leads to an analytic, semi-classical model for strongly-coupled QCD which has scale invariance and dimensional counting at short distances and color confinement at large distances. Although QCD is not conformally invariant, one can nevertheless use the mathematical representation of the conformal group in five-dimensional anti-de Sitter space to construct a first approximation to the theory. The AdS/CFT correspondence also provides insights into the inherently non-perturbative aspects of QCD, such as the orbital and radial spectra of hadrons and the form of hadronic wavefunctions. In particular, we show that there is an exact correspondence between the fifth-dimensional coordinate of AdS space z and a specific impact variable {zeta} which measures the separation of the quark and gluonic constituents within the hadron in ordinary space-time. This connection allows one to compute the analytic form of the frame-independent light-front wavefunctions, the fundamental entities which encode hadron properties and allow the computation of decay constants, form factors, and other exclusive scattering amplitudes. New relativistic lightfront equations in ordinary space-time are found which reproduce the results obtained using the 5-dimensional theory. The effective light-front equations possess remarkable algebraic structures and integrability properties. Since they are complete and orthonormal, the AdS/CFT model wavefunctions can also be used as a basis for the diagonalization of the full light-front QCD Hamiltonian, thus systematically improving the AdS/CFT approximation.

  16. Maximal temperature of a gas in AdS spacetime (United States)

    Dai, De-Chang; Stojkovic, Dejan


    Assuming only statistical mechanics and general relativity, we calculate the maximal temperature of gas of particles placed in anti-de Sitter (AdS) spacetime. If two particles with a given center of mass energy come close enough, according to classical gravity, they will form a black hole. We focus only on the black holes with a Hawking temperature lower than the environment, because they do not disappear. The number density of such black holes grows with the temperature in the system. At a certain finite temperature, the thermodynamical system will be dominated by black holes. This critical temperature is lower than the Planck temperature for the values of the AdS vacuum energy density below the Planck density. This result might be interesting from the AdS/CFT correspondence point of view, since it is different from the Hawking-Page phase transition, and it is not immediately clear what effect dynamically limits the maximal temperature of the thermal state on the CFT side of the correspondence.

  17. Unifying Subjectivity and Objectivity

    Directory of Open Access Journals (Sweden)

    Murugesan Chandrasekaran


    Full Text Available The contribution of modern science to the progress of civilization is immeasurable. Even its tendency toward exclusive concentration on the objective world has had salutary effects of great value. Modern science has wiped away much that was merely superstitious or speculative. Its rejection of unfounded opinions and prejudices has helped the thinking mind question conventional beliefs, shed preferences and prejudices, and challenge established authority. But modern systems thinking inherited from natural science is the suppression of the subjective dimension of reality. Many complex systems are an attempt to define and represent all subjective experience in physical terms. The modern man has a bias towards objectivity. The powerful influence of sense impressions on his mind and thinking makes him ignore the subjective experience and consider only objective facts as a valid, legitimate and representation of reality. Observing objective factors that are physical is easier than observing subjective factors that are subtle. The mechanistic view of reality has led to the rejection of the role of the individual in social development as insignificant. The individuals determine the development of society. Their social power has its roots both in subjective factors and objective factors. Economy, politics, society, and culture are inseparable dimensions of a single integrated reality. Subject and object constitute an integrated whole. The mind sees them as separate and independent. Or it views one as completely subordinate to the other. Unbiased approach to the study of all human experiences may prove that subject and object are interdependent dimensions or elements of reality.

  18. The role of professor V. I. Dolotsky in the development of Lliturgics as science and academic subject in Russian higher Church education


    Nikolai Karamyshev


    This paper is devoted to one of the key moments in liturgical studies in Russian higher church education. This moment was outwardly marked by the introduction of the new term “liturgics” instead of the old term “church antiquities” in the 1840s. The article shows the role of Professor Dolotsky in the development of liturgics as a science and an academic subject. Based on the analysis of survived manuscript documents, lithoprinted lecture notes and papers, we demonstrate that the introduction ...


    Directory of Open Access Journals (Sweden)

    D.N. Bakhrakh


    Full Text Available The question about the subjects of law branches is concerning the number of most important and difficult in law science. Its right decision influences on the subject of law regulation, precise definition of addressees of law norms, the volume of their rights and duties, the limits of action of norms of Main part of the branch, its principles. Scientific investigations, dedicated to law subjects system, promote the development of recommendations for the legislative and law applying activity; they are needed for scientific work organization and student training, for preparing qualified lawyers.

  20. Perceived subject outcomes and impact on health-related quality of life associated with diet using the new Food Benefits Assessment (FBA) questionnaire: development and psychometric validation. (United States)

    Guyonnet, Denis; Chassany, Olivier; Picard, Céline; Guillemin, Isabelle; Meunier, Juliette; Seignobos, Eva; Vigneux, Marc; Lassel, Taous; Trudeau, Elyse


    To assess the perceived outcomes associated with diet/food intake in the general adult population. The Food Benefits Assessment (FBA) questionnaire was developed from subjects' verbatim transcripts (n 18) and after comprehension tests (n 5). Normal-weight (n 130) and overweight (n 67) subjects then completed the final questionnaire twice, 7 d apart. Psychometric properties were assessed, including construct validity by principal components analysis (PCA), concurrent validity (Spearman coefficient) with the Short Form-36 scale (SF-36), known-group validity by comparing FBA dimension scores according to lifestyle and clinical variables, internal consistency reliability (Cronbach's alpha) and test-retest reproducibility in stable subjects over 1 week (intraclass correlation coefficient, ICC). PCA and Multitrait analysis confirmed the final version of the FBA comprising forty-one items split into seven dimensions (vitality; digestive comfort; physical appearance; well-being; snacking; disease prevention; aesthetics). All dimensions displayed good item convergent validity (0.44 to 0.80), good concurrent validity (highest correlation between well-being dimension of FBA and mental health scale of SF-36, r=0.83) and good known-group validity and reproducibility (ICC >or= 0.76); internal consistency reliability was good to excellent (Cronbach's alpha=0.79 to 0.91). The FBA is the first valid and reliable questionnaire that allows the assessment of diet effects and impact as perceived by subjects. It is a good candidate in the nutrition field for further use in specific population settings and with a particular food or daily diet. Linguistically validated English (UK and US) and German versions of the questionnaire are available.

  1. Free field realization of superstring theory on AdS3

    Energy Technology Data Exchange (ETDEWEB)

    Hofman, Diego M. E-mail:; Nunez, Carmen A


    The Coulomb gas representation of expectation values in SU(2) conformal field theory developed by Dotsenko is extended to the SL(2,R) WZW model and applied to bosonic string theory on AdS3 and to Type II superstrings on AdS3 x N. The spectral flow symmetry is included in the free field realization of vertex operators creating superstring states of both Ramond and Neveu-Schwarz sectors. Conjugate representations for these operators are constructed and a background charge prescription is designed to compute correlation functions. Two and three point functions of bosonic and fermionic string states in arbitrary winding sectors are calculated. Scattering amplitudes that violate winding number conservation are also discussed. (author)

  2. Fermionic currents in AdS spacetime with compact dimensions (United States)

    Bellucci, S.; Saharian, A. A.; Vardanyan, V.


    We derive a closed expression for the vacuum expectation value (VEV) of the fermionic current density in a (D +1 )-dimensional locally AdS spacetime with an arbitrary number of toroidally compactified Poincaré spatial dimensions and in the presence of a constant gauge field. The latter can be formally interpreted in terms of a magnetic flux treading the compact dimensions. In the compact subspace, the field operator obeys quasiperiodicity conditions with arbitrary phases. The VEV of the charge density is zero and the current density has nonzero components along the compact dimensions only. They are periodic functions of the magnetic flux with the period equal to the flux quantum and tend to zero on the AdS boundary. Near the horizon, the effect of the background gravitational field is small and the leading term in the corresponding asymptotic expansion coincides with the VEV for a massless field in the locally Minkowski bulk. Unlike the Minkowskian case, in the system consisting of an equal number of fermionic and scalar degrees of freedom, with same masses, charges and phases in the periodicity conditions, the total current density does not vanish. In these systems, the leading divergences in the scalar and fermionic contributions on the horizon are canceled and, as a consequence of that, the charge flux, integrated over the coordinate perpendicular to the AdS boundary, becomes finite. We show that in odd spacetime dimensions the fermionic fields realizing two inequivalent representations of the Clifford algebra and having equal phases in the periodicity conditions give the same contribution to the VEV of the current density. Combining the contributions from these fields, the current density in odd-dimensional C -,P - and T -symmetric models are obtained. As an application, we consider the ground state current density in curved carbon nanotubes described in terms of a (2 +1 )-dimensional effective Dirac model.

  3. Entanglement entropy and duality in AdS4

    Directory of Open Access Journals (Sweden)

    Ioannis Bakas


    Full Text Available Small variations of the entanglement entropy δS and the expectation value of the modular Hamiltonian δE are computed holographically for circular entangling curves in the boundary of AdS4, using gravitational perturbations with general boundary conditions in spherical coordinates. Agreement with the first law of thermodynamics, δS=δE, requires that the line element of the entangling curve remains constant. In this context, we also find a manifestation of electric–magnetic duality for the entanglement entropy and the corresponding modular Hamiltonian, following from the holographic energy–momentum/Cotton tensor duality.

  4. Education, Subject, and Human Development

    Directory of Open Access Journals (Sweden)



    Full Text Available Cambios acelerados en la producción, procesamiento y distribuciónde la información; avances en la ciencia y la tecnología;reconfiguración de las estructuras de poder y de las formas deejercicio de la ciudadanía; así como crisis de diverso orden, sonsolamente algunos de los fenómenos que marcan el mundo dehoy. Este campo de tensiones interpela a la educación, la cual seve puesta en cuestión y es desafiada a transformarse y a agenciarprocesos de formación haciendo frente a criterios eficientistasque intentan imponerse, en no pocas ocasiones, sobreaquellos de tipo pedagógico orientados a la generación de condicionesde desarrollo social.

  5. Infrastructure Development as a Condition for Improving the Mechanism of Innovative Activity Stimulation (on the Example of Southern Federal District Subjects

    Directory of Open Access Journals (Sweden)

    Nadezhda Nikolaevna Lebedeva


    Full Text Available The article discusses the concept of the mechanism of innovative activity stimulation, which represents a system consisting of actors with their goals; formal regulations (legislation; informal regulations and rules (business culture, adopted by the economic community; incentives and constraints (economic and non-economic in nature. The authors specify the understanding of infrastructure as a condition of the mechanism functioning, compare rating assessments (by the NAIDIT technique of innovation activity of subjects of the Southern Federal District (SFD and reveal significant inconsistencies. The comparative analysis of the main existing infrastructure elements of the innovation sphere (Krasnodar, Volgograd and Rostov regions let make conclusions about their sufficiency or insufficiency in different subjects of the macro-region. The negative trends of innovative infrastructure development include: the lack of a unified information and analytical database and system for the promotion and support of innovative projects; the lack of consolidated data to assess the development level of the regional innovative infrastructure in formal source; the failure and the need for development elements, such as clusters and science-technology parks, support funds and the creation of extensive networks of centers for collective use. Directions of improvement of innovation activity are presented on the basis of comparing its peculiar indicators as well as analyzing and identifying missing infrastructure elements of the innovation system (scientific and investment, information and analytical, organizational and communicative with the aim of increasing the efficiency of existing mechanisms of innovation stimulation in the regions. Scientific and practical significance of this work consists in the future use of its provisions and conclusions as additional theoretical and methodological substantiation of scientific developments in research of innovative activity

  6. Development of the Complex General Linear Model in the Fourier Domain: Application to fMRI Multiple Input-Output Evoked Responses for Single Subjects

    Directory of Open Access Journals (Sweden)

    Daniel E. Rio


    Full Text Available A linear time-invariant model based on statistical time series analysis in the Fourier domain for single subjects is further developed and applied to functional MRI (fMRI blood-oxygen level-dependent (BOLD multivariate data. This methodology was originally developed to analyze multiple stimulus input evoked response BOLD data. However, to analyze clinical data generated using a repeated measures experimental design, the model has been extended to handle multivariate time series data and demonstrated on control and alcoholic subjects taken from data previously analyzed in the temporal domain. Analysis of BOLD data is typically carried out in the time domain where the data has a high temporal correlation. These analyses generally employ parametric models of the hemodynamic response function (HRF where prewhitening of the data is attempted using autoregressive (AR models for the noise. However, this data can be analyzed in the Fourier domain. Here, assumptions made on the noise structure are less restrictive, and hypothesis tests can be constructed based on voxel-specific nonparametric estimates of the hemodynamic transfer function (HRF in the Fourier domain. This is especially important for experimental designs involving multiple states (either stimulus or drug induced that may alter the form of the response function.

  7. AdS pure spinor superstring in constant backgrounds

    Energy Technology Data Exchange (ETDEWEB)

    Chandia, Osvaldo [Departamento de Ciencias, Facultad de Artes Liberales, Universidad Adolfo Ibáñez,Facultad de Ingeniería y Ciencias, Universidad Adolfo Ibáñez,Diagonal Las Torres 2640, Peñalolén, Santiago (Chile); Bevilaqua, L. Ibiapina [Escola de Ciências e Tecnologia, Universidade Federal do Rio Grande do Norte,Caixa Postal 1524, 59072-970, Natal, RN (Brazil); Vallilo, Brenno Carlini [Facultad de Ciencias Exactas, Departamento de Ciencias Físicas, Universidad Andres Bello,Republica 220, Santiago (Chile)


    In this paper we study the pure spinor formulation of the superstring in AdS{sub 5}×S{sup 5} around point particle solutions of the classical equations of motion. As a particular example we quantize the pure spinor string in the BMN background.

  8. Early smoking-induced lung lesions in asymptomatic subjects. Correlations between high resolution dynamic CT and pulmonary function testing; Danno polmonare precoce da fumo in soggetti asintomatici. Studio correlativo con TC dinamica ad elevata risoluzione e test di funzionalita' respiratoria

    Energy Technology Data Exchange (ETDEWEB)

    Spaggiari, Enrica; Zompadori, Maurizio; Bna' , Claudio; Ormitti, Francesca; Svaerzellati, Nicola; Rabaiotti, Enrico [Parma Univ., Parma (Italy). Sezione di Diagnostica per Immagini e UO di Scienze Radiologiche Dipartimento di Scienze Cliniche; Verduri, Alessia; Chetta, Alfredo [Parma Univ., Parma (Italy). Sezione Clinica Pneumologica


    Purpose: To evaluate the prevalence and significance of the pathological effects of cigarette smoking on the lung and the sensitivity of high-resolution CT (HRCT) in the recognition of early smoking-induced lesions in asymptomatic former of current smokers. Materials and methods: We performed a prospective and consecutive analysis of 36 volunteers (16 males, 20 females), 10 non-smokers (3 males, 7 females) and 26 smokers (13 males, 13 females / 17 current smokers; 9 former smokers), all asymptomatic and with normal respiratory flows. These subjects underwent lung function testing and HRCT, after providing written informed consent for the study. The HRCT scans were obtained at three pre-selected levels (aortic arch, tracheal carina and venous hilum). The same scans were obtained in post-expiration phase. At the level of the apical segmental bronchus of the right upper lobe, we measured on the monitor wall thickening, and the total and internal diameters using the techniques reported in literature. Each study was independently evaluated by two radiologists that were blinded to all clinical and functional data: they also evaluated the presence, prevalence and type of emphysema, areas of patchy hyperlucency and oligoemia in the inspiration phase and areas of expiratory air trapping. The extension was evaluated with the visual score method. The data obtained were analysed with the Windows SPSS package for statistical analysis. Results: The two groups (non smokers and smokers) showed significant differences in some functional tests such as FEV1 (p<0.005) and Tiffeneau index (p<0.005) which were lower in current-smokers or former-smokers, although still within the normal range. The HRCT study did not show areas of emphysema or air trapping in non smokers. In the smokers' group, air trapping was observed in 30.7% of cases: 33% former-smokers and 29.4% current smokers (mean extension was 21.36% in former smokers and 9.48% in current smokers). Mean extension in the

  9. Numerical Simulations of Asymptotically AdS Spacetimes (United States)

    Bantilan, Hans

    In this dissertation, we introduce a numerical scheme to construct asymptotically anti-de Sitter spacetimes with Lorentzian signature, focusing on cases that preserve five-dimensional axisymmetry. We study the field theories that are dual to these spacetimes by appealing to the AdS/CFT correspondence in the regime where the gravity dual is completely described by Einstein gravity. The numerical scheme is based on generalized harmonic evolution, and we begin by obtaining initial data defined on some Cauchy hypersurface. For the study described in this dissertation, we use a scalar field to source deviations from pure AdS5, and obtain data that correspond to highly deformed black holes. We evolve this initial data forward in time, and follow the subsequent ringdown. What is novel about this study is that the initial horizon geometry cannot be considered a small perturbation of the final static horizon, and hence we are probing an initial non-linear phase of the evolution of the bulk spacetime. On the boundary, we find that the dual CFT stress tensor behaves like that of a thermalized N = 4 SYM fluid. We find that the equation of state of this fluid is consistent with conformal invariance, and that its transport coefficients match those previously calculated for an N = 4 SYM fluid via holographic methods. Modulo a brief transient that is numerical in nature, this matching appears to hold from the initial time onwards. We transform these solutions computed in global AdS onto a Minkowski piece of the boundary, and examine the temperature of the corresponding fluid flows. Under this transformation, the spatial profile of temperature at the initial time resembles a Lorentz-flattened pancake centered at the origin of Minkowski space. By interpreting the direction along which the data is flattened as the beam-line direction, our initial data can be thought of as approximating a head-on heavy ion collision at its moment of impact.

  10. Smooth causal patches for AdS black holes (United States)

    Raju, Suvrat


    We review the paradox of low energy excitations of a black hole in anti-de Sitter space (AdS). An appropriately chosen unitary operator in the boundary theory can create a locally strong excitation near the black hole horizon, whose global energy is small as a result of the gravitational redshift. The paradox is that this seems to violate a general rule of statistical mechanics, which states that an operator with energy parametrically smaller than k T cannot create a significant excitation in a thermal system. When we carefully examine the position dependence of the boundary unitary operator that produces the excitation and the bulk observable necessary to detect the anomalously large effect, we find that they do not both fit in a single causal patch. This follows from a remarkable property of position-space AdS correlators that we establish explicitly and resolves the paradox in a generic state of the system, since no combination of observers can both create the excitation and observe its effect. As a special case of our analysis, we show how this resolves the "Born rule" paradox of Marolf and Polchinski [J. High Energy Phys. 01 (2016) 008, 10.1007/JHEP01(2016)008] and we verify our solution using an independent calculation. We then consider boundary states that are finely tuned to display a spontaneous excitation outside the causal patch of the infalling observer, and we propose a version of causal patch complementarity in AdS/CFT that resolves the paradox for such states as well.

  11. ADS-B in space

    DEFF Research Database (Denmark)

    Knudsen, Bjarke Gosvig; Jensen, Morten; Birklykke, Alex


    them to the terrestrial receivers. This paper gives an overview of the GATOSS mission and of its highly-sensitive ADS-B software-defined radio receiver payload. Details of the design and implementation of the receiver's decoder are introduced. The first real-life, space-based results show that ADS......-B signals are indeed successfully received in space and retransmitted to a terrestrial station by the GATOSS nano-satellite orbiting at 700+ km altitudes, thus showing that GATOSS is capable of tracking flights, including transoceanic ones, from space....

  12. Do subjective memory complaints predict senile Alzheimer dementia? (United States)

    Jungwirth, Susanne; Zehetmayer, Sonja; Weissgram, Silvia; Weber, Germain; Tragl, Karl Heinz; Fischer, Peter


    Many elderly complain about their memory and undergo dementia screening by the Mini-Mental State Examination (MMSE). While objective memory impairment always precedes Alzheimer dementia (AD) it is unclear whether subjective memory complaints are predicting AD. We tried to answer this question in a prospective cohort study. The 75-years old non-demented inhabitants of Vienna-Transdanube were investigated for conversion to AD after 30 months. The predictive value of subjective memory complaints was analysed in two groups: subjects with high MMSE-score (28-30) and subjects with low MMSE-score (23-27). Only in subjects with high MMSE univariate analyses showed an association between subjective memory complaints and incident AD. In both groups the verbal memory test was the main predictor of AD in multivariate analyses. We suggest to perform memory testing in subjects complaining about memory irrespective of their performance in a screening procedure like the MMSE.

  13. Hairy AdS black holes with a toroidal horizon in 4D Einstein-nonlinear omega-model system

    Czech Academy of Sciences Publication Activity Database

    Astorino, M.; Canfora, F.; Giacomini, A.; Ortaggio, Marcello


    Roč. 776, 10 January (2018), s. 236-241 ISSN 0370-2693 R&D Projects: GA ČR GB14-37086G Institutional support: RVO:67985840 Keywords : AdS black holes * nonlinear sigma model Subject RIV: BA - General Mathematics OBOR OECD: Applied mathematics Impact factor: 4.807, year: 2016

  14. Value Adding Management: A New Facilities Management Concept

    DEFF Research Database (Denmark)

    Jensen, Per Anker; Katchamart, Akarapong


    the relevance of the basic concept and provides an important example of how Value Adding Management can be implemented and added value measured. Originality/value: The study develops a concept of Value Adding Management, which is new in FM literature. It is expected to increase the awareness of the impacts......Purpose: To investigate how Facilities Management (FM) can add value and develop a management concept that can assist facilities managers in implementing value adding strategies and practices. Theory: The study is based on the management model for FM included in the European FM standards, recent...... theories on added value of FM and real estate and the related concept of Value Management from building projects. The study is related to the EuroFM research group on The Added Value of FM. Design/methodology/approach: The study outlines a preliminary theoretical based management concept, which...

  15. A description of a staff development program: Preparing the elementary school classroom teacher to lead environmental field trips and to use an integrated subject approach to environmental education (United States)

    Egana, John Joseph

    This study of the Field Trip Specialist Program (FTS) described how a professional development plan fostered change in the traditional roles of third and fourth grade teachers. Teachers that volunteered were prepared to become interpretive guides for their class on environmental field trips, integrate their basic subject areas lessons into an environmental science context, and develop their self-perception as professional educators. This qualitative study made use of quantitative data and drew on information collected over four years from surveys, interviews, classroom observations, field trip and workshop observations, focus groups, journals and assessments performed in Florida. The FTS Program attracted teachers who thought it was important for all students to understand environmental issues, and these teachers believed in integrated instruction. These beliefs were inconsistent with many aspects of school culture. FTS invited the participation of these teachers and encouraged them to take control of the program by serving as instructors and program developers. Teachers described themselves as prepared to deliver the FTS Program with a high level of motivation and relevance. They also credited the program as beneficial in preparation for the Florida Comprehensive Assessment Tests (FCAT). Teachers reported that their responsibility as field trip leaders was the primary factor motivating them to provide conscientious presentation of pre- and post-field trip lessons and thorough integration of environmental topics in basic subject area instruction. Despite the impact of the field trip leadership factor, I could not find another program in the State of Florida that required teachers to lead their own field trips. Other influential factors specific to this program were: Voluntary participation, on-site field instruction, peer instructors and program developers, high quality and task specific materials, and pre- and post-assessments for students. Factors were identified

  16. Development of an effective dose coefficient database using a computational human phantom and Monte Carlo simulations to evaluate exposure dose for the usage of NORM-added consumer products. (United States)

    Yoo, Do Hyeon; Shin, Wook-Geun; Lee, Jaekook; Yeom, Yeon Soo; Kim, Chan Hyeong; Chang, Byung-Uck; Min, Chul Hee


    After the Fukushima accident in Japan, the Korean Government implemented the "Act on Protective Action Guidelines Against Radiation in the Natural Environment" to regulate unnecessary radiation exposure to the public. However, despite the law which came into effect in July 2012, an appropriate method to evaluate the equivalent and effective doses from naturally occurring radioactive material (NORM) in consumer products is not available. The aim of the present study is to develop and validate an effective dose coefficient database enabling the simple and correct evaluation of the effective dose due to the usage of NORM-added consumer products. To construct the database, we used a skin source method with a computational human phantom and Monte Carlo (MC) simulation. For the validation, the effective dose was compared between the database using interpolation method and the original MC method. Our result showed a similar equivalent dose across the 26 organs and a corresponding average dose between the database and the MC calculations of database with sufficient accuracy. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Ad hoc mobile wireless networks principles, protocols and applications

    CERN Document Server

    Sarkar, Subir Kumar; Puttamadappa, C


    Ad hoc mobile wireless networks have seen increased adaptation in a variety of disciplines because they can be deployed with simple infrastructures and virtually no central administration. In particular, the development of ad hoc wireless and sensor networks provides tremendous opportunities in areas including disaster recovery, defense, health care, and industrial environments. Ad Hoc Mobile Wireless Networks: Principles, Protocols and Applications explains the concepts, mechanisms, design, and performance of these systems. It presents in-depth explanations of the latest wireless technologies

  18. Total daily physical activity and the risk of AD and cognitive decline in older adults. (United States)

    Buchman, A S; Boyle, P A; Yu, L; Shah, R C; Wilson, R S; Bennett, D A


    Studies examining the link between objective measures of total daily physical activity and incident Alzheimer disease (AD) are lacking. We tested the hypothesis that an objective measure of total daily physical activity predicts incident AD and cognitive decline. Total daily exercise and nonexercise physical activity was measured continuously for up to 10 days with actigraphy (Actical®; Philips Healthcare, Bend, OR) from 716 older individuals without dementia participating in the Rush Memory and Aging Project, a prospective, observational cohort study. All participants underwent structured annual clinical examination including a battery of 19 cognitive tests. During an average follow-up of about 4 years, 71 subjects developed clinical AD. In a Cox proportional hazards model adjusting for age, sex, and education, total daily physical activity was associated with incident AD (hazard ratio = 0.477; 95% confidence interval 0.273-0.832). The association remained after adjusting for self-report physical, social, and cognitive activities, as well as current level of motor function, depressive symptoms, chronic health conditions, and APOE allele status. In a linear mixed-effect model, the level of total daily physical activity was associated with the rate of global cognitive decline (estimate 0.033, SE 0.012, p = 0.007). A higher level of total daily physical activity is associated with a reduced risk of AD.

  19. Adding Value to Indiana's Commodities. (United States)

    Welch, Mary A., Ed.


    Food processing plants are adding value to bulk and intermediate products to sell overseas. The Asian Pacific Rim economies constituted the largest market for consumer food products in 1993. This shift toward consumer food imports in this area is due to more women working outside the home, the internationalization of populations, and dramatic…

  20. Facilities Management and Added Value

    DEFF Research Database (Denmark)

    Jensen, Per Anker


    Aim: This paper aims to present different models of the concept of the added value of Facilities Management (FM), including the FM Value Map, which forms the basis of research group in EuroFM, and to present some of the results of this research collaboration. Approach and methodology: The paper i...

  1. Reproducibility of ad libitum energy intake with the use of a computerized vending machine system123 (United States)

    Votruba, Susanne B; Franks, Paul W; Krakoff, Jonathan; Salbe, Arline D


    Background: Accurate assessment of energy intake is difficult but critical for the evaluation of eating behavior and intervention effects. Consequently, methods to assess ad libitum energy intake under controlled conditions have been developed. Objective: Our objective was to evaluate the reproducibility of ad libitum energy intake with the use of a computerized vending machine system. Design: Twelve individuals (mean ± SD: 36 ± 8 y old; 41 ± 8% body fat) consumed a weight-maintaining diet for 3 d; subsequently, they self-selected all food with the use of a computerized vending machine system for an additional 3 d. Mean daily energy intake was calculated from the actual weight of foods consumed and expressed as a percentage of weight-maintenance energy needs (%WMEN). Subjects repeated the study multiple times during 2 y. The within-person reproducibility of energy intake was determined through the calculation of the intraclass correlation coefficients (ICCs) between visits. Results: Daily energy intake for all subjects was 5020 ± 1753 kcal during visit 1 and 4855 ± 1615 kcal during visit 2. There were no significant associations between energy intake and body weight, body mass index, or percentage body fat while subjects used the vending machines, which indicates that intake was not driven by body size or need. Despite overconsumption (%WMEN = 181 ± 57%), the reproducibility of intake between visits, whether expressed as daily energy intake (ICC = 0.90), %WMEN (ICC = 0.86), weight of food consumed (ICC = 0.87), or fat intake (g/d; ICC = 0.87), was highly significant (P < 0.0001). Conclusion: Although ad libitum energy intake exceeded %WMEN, the within-person reliability of this intake across multiple visits was high, which makes this a reproducible method for the measurement of ad libitum intake in subjects who reside in a research unit. This trial was registered at as NCT00342732. PMID:19923376

  2. Reproducibility of ad libitum energy intake with the use of a computerized vending machine system. (United States)

    Venti, Colleen A; Votruba, Susanne B; Franks, Paul W; Krakoff, Jonathan; Salbe, Arline D


    Accurate assessment of energy intake is difficult but critical for the evaluation of eating behavior and intervention effects. Consequently, methods to assess ad libitum energy intake under controlled conditions have been developed. Our objective was to evaluate the reproducibility of ad libitum energy intake with the use of a computerized vending machine system. Twelve individuals (mean + or - SD: 36 + or - 8 y old; 41 + or - 8% body fat) consumed a weight-maintaining diet for 3 d; subsequently, they self-selected all food with the use of a computerized vending machine system for an additional 3 d. Mean daily energy intake was calculated from the actual weight of foods consumed and expressed as a percentage of weight-maintenance energy needs (%WMEN). Subjects repeated the study multiple times during 2 y. The within-person reproducibility of energy intake was determined through the calculation of the intraclass correlation coefficients (ICCs) between visits. Daily energy intake for all subjects was 5020 + or - 1753 kcal during visit 1 and 4855 + or - 1615 kcal during visit 2. There were no significant associations between energy intake and body weight, body mass index, or percentage body fat while subjects used the vending machines, which indicates that intake was not driven by body size or need. Despite overconsumption (%WMEN = 181 + or - 57%), the reproducibility of intake between visits, whether expressed as daily energy intake (ICC = 0.90), %WMEN (ICC = 0.86), weight of food consumed (ICC = 0.87), or fat intake (g/d; ICC = 0.87), was highly significant (P < 0.0001). Although ad libitum energy intake exceeded %WMEN, the within-person reliability of this intake across multiple visits was high, which makes this a reproducible method for the measurement of ad libitum intake in subjects who reside in a research unit. This trial was registered at as NCT00342732.

  3. Incorporating the patient's perspective into drug development and communication: an ad hoc task force report of the Patient-Reported Outcomes (PRO) Harmonization Group meeting at the Food and Drug Administration, February 16, 2001. (United States)

    Acquadro, Catherine; Berzon, Rick; Dubois, Dominique; Leidy, Nancy Kline; Marquis, Patrick; Revicki, Dennis; Rothman, Margaret


    The extent to which patient-based outcomes can be used to evaluate and communicate the effect of new drugs and devices is a subject of much debate. Criteria for evaluating the scientific quality of data to support health-related quality of life (HRQL) and other patient-based labeling and promotional claims in the United States and Europe have been proposed by various scientists and organizations. Since March 2000, a working group composed of members of the International Society for Quality of Life Research (ISOQOL), the International Society for Pharmacoeconomics and Outcomes Research (ISPOR), the Pharmaceutical Manufacturer's Association Health Outcomes Committee (PhRMA-HOC), and the European Regulatory Issues on Quality of Life Assessment (ERIQA) met to discuss and coordinate the various recommendations by their respective groups and address the need to harmonize outcomes review criteria within and across United States and European regulatory agencies. Over time, the discussion expanded from HRQL outcomes to include any outcome based on data provided by the patient or patient proxy, that is, patient-reported outcomes (PROs). The working group therefore became known as the PRO Harmonization Group. Working with a member of the US Food and Drug Administration (FDA), four key issues requiring clarification were identified: how PROs are defined and put into operation for research purposes; the added value of PROs in the drug review and evaluation process; selected questions related to the PRO measurement and research methodology; and the interest and demand for PRO information by decision makers. On February 15, 2001, all members of the PRO Harmonization Group attended a meeting in Rockville, Maryland, to discuss these four issues further, and on February 16, 2001, a formal presentation was made to representatives from various departments and reviewing divisions of the FDA. These presentations are summarized in this report. All participants agreed that PROs are

  4. Black holes as bubbles of AdS (United States)

    Danielsson, U. H.; Dibitetto, G.; Giri, S.


    In this paper we propose that bubbles of AdS within Minkowski spacetime, stabilized at a finite radius by stiff matter and an electromagnetic gas, can be an alternative endpoint of gravitational collapse. The bubbles are horizonless with a size up to 12.5% larger than their Schwarzschild radius depending on their charge. We argue that they are stable against small perturbations, and have thermodynamical properties similar to those of real black holes. We provide a realization of the bubbles within string theory that relies on a specific brane intersection giving rise to a shell carrying dissolved charges from lower dimensional D-branes as well as a gas of open strings. We also note that our construction provides a new way of understanding the entropy of Reissner-Nordström black holes in the extremal limit.

  5. Colliding waves on a string in AdS$_3$

    CERN Document Server

    Vegh, David


    This paper is concerned with the classical motion of a string in global AdS$_3$. The initially static string stretches between two antipodal points on the boundary circle. Both endpoints are perturbed which creates cusps at a steady rate. The cusps propagate towards the interior where they collide. The behavior of the string depends on the strength of forcing. Three qualitatively different phases can be distinguished: transparent, gray, and black. The transparent region is analogous to a standing wave. In the black phase, there is a horizon on the worldsheet and cusps never reach the other endpoint. The string keeps folding and its length grows linearly over time. In the gray phase, the string still grows linearly. However, cusps do cross to the other side. The transparent and gray regions are separated by a transition point where a logarithmic accumulation of cusps is numerically observed. A simple model reproduces the qualitative behavior of the string in the three phases.

  6. Massless AdS 2 scattering and Bethe ansatz (United States)

    Fontanella, A.; Torrielli, A.


    We first analyse the integrable scattering theory describing the massless excitations of AdS 2 × S 2 × T 6 superstrings in the relativistic limit. The matrix part of the S-matrix is obtained in the BMN limit from the conjectured exact expression, and compared to known S-matrices with N=1 supersymmetry in 1 + 1 dimensions. A dressing factor, yet unknown for the complete theory, is here constructed based on relativistic crossing symmetry. We derive a Bethe-ansatz condition by employing a transfer-matrix technique based on the so-called free-fermion condition. This is known to overcome the problem of lack of a reference state. We then generalise the method to the massless non-relativistic case, and compare the resulting Bethe-ansatz condition with a simple massless limit of the one conjectured by Sorokin, Tseytlin, Wulff and Zarembo.

  7. Thermodynamics of charged Lovelock: AdS black holes

    Energy Technology Data Exchange (ETDEWEB)

    Prasobh, C.B.; Suresh, Jishnu; Kuriakose, V.C. [Cochin University of Science and Technology, Department of Physics, Cochin (India)


    We investigate the thermodynamic behavior of maximally symmetric charged, asymptotically AdS black hole solutions of Lovelock gravity. We explore the thermodynamic stability of such solutions by the ordinary method of calculating the specific heat of the black holes and investigating its divergences which signal second-order phase transitions between black hole states. We then utilize the methods of thermodynamic geometry of black hole spacetimes in order to explain the origin of these points of divergence. We calculate the curvature scalar corresponding to a Legendre-invariant thermodynamic metric of these spacetimes and find that the divergences in the black hole specific heat correspond to singularities in the thermodynamic phase space. We also calculate the area spectrum for large black holes in the model by applying the Bohr-Sommerfeld quantization to the adiabatic invariant calculated for the spacetime. (orig.)

  8. Adiabatic pumping solutions in global AdS (United States)

    Carracedo, Pablo; Mas, Javier; Musso, Daniele; Serantes, Alexandre


    We construct a family of very simple stationary solutions to gravity coupled to a massless scalar field in global AdS. They involve a constantly rising source for the scalar field at the boundary and thereby we name them pumping solutions. We construct them numerically in D = 4. They are regular and, generically, have negative mass. We perform a study of linear and nonlinear stability and find both stable and unstable branches. In the latter case, solutions belonging to different sub-branches can either decay to black holes or to limiting cycles. This observation motivates the search for non-stationary exactly timeperiodic solutions which we actually construct. We clarify the role of pumping solutions in the context of quasistatic adiabatic quenches. In D = 3 the pumping solutions can be related to other previously known solutions, like magnetic or translationally-breaking backgrounds. From this we derive an analytic expression.

  9. Worldsheet dilatation operator for the AdS superstring

    Energy Technology Data Exchange (ETDEWEB)

    Ramírez, Israel [Departamento de Física, Universidad Técnica Federico Santa María,Casilla 110-V, Valparaíso (Chile); Institut für Mathematik und Institut für Physik, Humboldt-Universität zu Berlin,IRIS Haus, Zum Großen Windkanal 6, 12489 Berlin (Germany); Vallilo, Brenno Carlini [Departamento de Ciencias Físicas, Universidad Andres Bello,Republica 220, Santiago (Chile)


    In this work we propose a systematic way to compute the logarithmic divergences of composite operators in the pure spinor description of the AdS{sub 5}×S{sup 5} superstring. The computations of these divergences can be summarized in terms of a dilatation operator acting on the local operators. We check our results with some important composite operators of the formalism.

  10. Brownian motion in AdS/CFT

    NARCIS (Netherlands)

    de Boer, J.; Hubeny, V.E.; Rangamani, M.; Shigemori, M.


    We study Brownian motion and the associated Langevin equation in AdS/CFT. The Brownian particle is realized in the bulk spacetime as a probe fundamental string in an asymptotically AdS black hole background, stretching between the AdS boundary and the horizon. The modes on the string are excited by

  11. Factors affecting subjective appearance evaluations among patients with congenital craniofacial conditions: An application of Cash's cognitive-behavioural model of body image development. (United States)

    Feragen, Kristin Billaud; Stock, Nicola Marie


    Satisfaction with appearance is of central importance for psychological well-being and health. For individuals with an unusual appearance, such as congenital craniofacial anomalies (CFA), appearance evaluations could be especially important. However, few, if any papers have presented a comprehensive synthesis of the factors found to affect subjective satisfaction with appearance among children, adolescents, and adults born with a CFA. Further, only a handful of craniofacial studies have applied psychological theories or models to their findings, resulting in an overall lack of guidance for researchers in the field. This paper summarises the literature pertaining to satisfaction with appearance among those affected by CFAs, and examines the extent to which Cash's cognitive-behavioural model of body image development (2012) fits with this literature. Given the overlap between factors of interest in the field of CFAs, and in the area of body image more broadly, a closer collaboration between the two research fields is suggested. Copyright © 2018 Elsevier Ltd. All rights reserved.


    Directory of Open Access Journals (Sweden)

    Elitsa Stoyanova PETROVA


    Full Text Available On the basis of an approved request by the Head of National Military University it is conducting research on motivation in military formations of the example of Vasil Levski National Military University in Veliko Tarnovo, Bulgaria. Subject of the study is motivation for training and military activities of the cadets and the objects of the study are students in professional military direction in "Organization and management of military units at the tactical level," Land forces faculty at the National Military University of Bulgaria. The article presents results of the study at second item - "Do you agree that the study of specialized topics is an important stage of your professional development of future military leader?". The interviewees were cadets who graduated through the following academic years - 2013/2014, 2014/2015, 2015/2016.

  13. [Current Developments of the Interdisciplinary Subject Rehabilitation, Physical Medicine, Naturopathic Treatment in the German Medical Faculties: Results of the DGRW Faculty Survey in 2015]. (United States)

    Schmidt, S; Bergelt, C; Deck, R; Krischak, G; Morfeld, M; Michel, M; Schwarzkopf, S R; Spyra, K; Walter, S; Mau, W


    To ascertain the current development of the rehabilitation-related medical teaching in the interdisciplinary subject Rehabilitation, Physical Medicine, Naturopathic Treatment (Q12) regarding its execution, content, exams and evaluation of teaching at the Medical Faculties the German Society of Rehabilitation Science conducted another faculty survey in 2015. Representatives of all degree courses of human medicine in German Universities (n=41) received a pseudonymised standardised questionnaire in summer 2015. The response rate was 76% (n=31). Half of the faculties (48%) stated that they had a teaching and research unit for at least 1 of the 3 subjects of the interdisciplinary Q12. The Q12-teaching of faculties including these units partially differed from the other faculties. Model medical education programmes provide on average 2 semesters more for Q12-teaching in comparison to the traditional programmes. More than 3 quarters of the traditional programmes and all other courses include other medical professionals besides physicians as lecturers. Multiple choice questions still constitute the most common examination type (94%). Nearly all Medical Faculties evaluate the rehabilitation-related teaching but only half of all them have implemented a financial gratification based on the evaluation results. Even 10 years after the implementation of Q12, major variations were demonstrated regarding the execution, content and methods of medical education in rehabilitation. In the future the influence of the National Competence Based Catalogues of Learning Objectives for Undergraduate Medical Education on the Q12-development and the Q12-teaching in medical university education in Germany with foreign qualification will be of particular interest. © Georg Thieme Verlag KG Stuttgart · New York.

  14. Subjective and objective peer approval evaluations and self-esteem development: A test of reciprocal, prospective, and long-term effects. (United States)

    Gruenenfelder-Steiger, Andrea E; Harris, Michelle A; Fend, Helmut A


    A large body of literature suggests a clear, concurrent association between peer approval and self-esteem in adolescence. However, little empirical work exists on either the prospective or reciprocal relation between peer approval and self-esteem during this age period. Moreover, it is unclear from past research whether both subjectively perceived peer approval and objectively measured peer approval are related to subsequent self-esteem over time (and vice versa) and whether these paths have long-term associations into adulthood. Using data from a large longitudinal study that covers a time span of 2 decades, we examined reciprocal, prospective relations between self-esteem and peer approval during ages 12-16 in addition to long-term relations between these variables and later social constructs at age 35. Cross-lagged regression analyses revealed small but persistent effect sizes from both types of peer approval to subsequent self-esteem in adolescence, controlling for prior self-esteem. However, effects in the reverse direction were not confirmed. These findings support the notion that peer relationships serve an important function for later self-esteem, consistent with many theoretical tenets of the importance of peers for building a strong identity. Finally, we found long-term relations between adult social constructs and adolescent objective and subjective peer approval as well as self-esteem. Therefore, not only do peer relationships play a role in self-esteem development across adolescence, but they remain impactful throughout adulthood. In sum, the current findings highlight the lasting, yet small link between peer relationships and self-esteem development and call for investigations of further influential factors for self-esteem over time. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  15. Timeliness of Creative Subjects in Architecture Education (United States)

    Vargot, T.


    The following article is about the problem of insufficient number of drawing and painting lessons delivered in the process of architectural education. There is a comparison between the education of successful architects of the past and modern times. The author stands for the importance of creative subjects being the essential part of development and education of future architects. Skills achieved during the study of creative subjects will be used not only as a mean of self-expression but as an instrument in the toolkit of a professional. Sergei Tchoban was taken as an example of a successful architect for whom the knowledge of a man-made drawing is very important. He arranges the contests of architectural drawings for students promoting creative development in this way. Nowadays, students tend to use computer programs to make architectural projects losing their individual approach. The creative process becomes a matter of scissors and paste being just a copy of something that already exists. The solution of the problem is the reconsideration of the department’s curriculum and adding extra hours for creative subjects.

  16. Certification bringing the added value to the market

    NARCIS (Netherlands)

    Wijnands, F.G.; Sukkel, W.


    More sustainable food production methods clearly provide an added value to society in comparison with traditional methods of farming. However, the question is: “value added to what?”. In this contribution, recent developments in certification are analysed against a historical background. These

  17. Value-Added Models for the Pittsburgh Public Schools (United States)

    Johnson, Matthew; Lipscomb, Stephen; Gill, Brian; Booker, Kevin; Bruch, Julie


    At the request of Pittsburgh Public Schools (PPS) and the Pittsburgh Federation of Teachers (PFT), Mathematica has developed value-added models (VAMs) that aim to estimate the contributions of individual teachers, teams of teachers, and schools to the achievement growth of their students. The authors' work in estimating value-added in Pittsburgh…

  18. Realizing "value-added" metrology (United States)

    Bunday, Benjamin; Lipscomb, Pete; Allgair, John; Patel, Dilip; Caldwell, Mark; Solecky, Eric; Archie, Chas; Morningstar, Jennifer; Rice, Bryan J.; Singh, Bhanwar; Cain, Jason; Emami, Iraj; Banke, Bill, Jr.; Herrera, Alfredo; Ukraintsev, Vladamir; Schlessinger, Jerry; Ritchison, Jeff


    The conventional premise that metrology is a "non-value-added necessary evil" is a misleading and dangerous assertion, which must be viewed as obsolete thinking. Many metrology applications are key enablers to traditionally labeled "value-added" processing steps in lithography and etch, such that they can be considered integral parts of the processes. Various key trends in modern, state-of-the-art processing such as optical proximity correction (OPC), design for manufacturability (DFM), and advanced process control (APC) are based, at their hearts, on the assumption of fine-tuned metrology, in terms of uncertainty and accuracy. These trends are vehicles where metrology thus has large opportunities to create value through the engineering of tight and targetable process distributions. Such distributions make possible predictability in speed-sorts and in other parameters, which results in high-end product. Additionally, significant reliance has also been placed on defect metrology to predict, improve, and reduce yield variability. The necessary quality metrology is strongly influenced by not only the choice of equipment, but also the quality application of these tools in a production environment. The ultimate value added by metrology is a result of quality tools run by a quality metrology team using quality practices. This paper will explore the relationships among present and future trends and challenges in metrology, including equipment, key applications, and metrology deployment in the manufacturing flow. Of key importance are metrology personnel, with their expertise, practices, and metrics in achieving and maintaining the required level of metrology performance, including where precision, matching, and accuracy fit into these considerations. The value of metrology will be demonstrated to have shifted to "key enabler of large revenues," debunking the out-of-date premise that metrology is "non-value-added." Examples used will be from critical dimension (CD

  19. The Subjectivity of Participation

    DEFF Research Database (Denmark)

    Nissen, Morten

    What is a 'we' – a collective – and how can we use such communal self-knowledge to help people? This book is about collectivity, participation, and subjectivity – and about the social theories that may help us understand these matters. It also seeks to learn from the innovative practices and ideas...... practices. Through this dialogue, it develops an original trans-disciplinary critical theory and practice of collective subjectivity for which the ongoing construction and overcoming of common sense, or ideology, is central. It also points to ways of relating discourse with agency, and fertilizing insights...... from interactionism and ideology theories in a cultural-historical framework....

  20. Adding Texture to Color: Quantitative Analysis of Color Emotions

    NARCIS (Netherlands)

    Lucassen, M.P.; Gevers, T.; Gijsenij, A.


    What happens to color emotion responses when texture is added to color samples? To quantify this we performed an experiment in which subjects ordered samples (displayed on a computer monitor) along four scales: Warm-Cool, Masculine-Feminine, Hard-Soft and Heavy-Light. Three sample types were used:

  1. Cost-savings accruable to removing value added tax from ...

    African Journals Online (AJOL)

    Background: Despite the important and essential role that medicines play in any society, all medicines, including those identified as essential, are uniformly subjected to 14% value added tax (VAT), regardless of their therapeutic value in the private healthcare sector of South Africa. The aim of this article is to demonstrate ...

  2. Review of AdS/CFT Integrability: An Overview

    CERN Document Server

    Beisert, Niklas; Alday, Luis F; Bajnok, Zoltan; Drummond, James M; Freyhult, Lisa; Gromov, Nikolay; Janik, Romuald A; Kazakov, Vladimir; Klose, Thomas; Korchemsky, Gregory P; Kristjansen, Charlotte; Magro, Marc; McLoughlin, Tristan; Minahan, Joseph A; Nepomechie, Rafael I; Rej, Adam; Roiban, Radu; Schafer-Nameki, Sakura; Sieg, Christoph; Staudacher, Matthias; Torrielli, Alessandro; Tseytlin, Arkady A; Vieira, Pedro; Volin, Dmytro; Zoubos, Konstantinos


    This is the introductory chapter of a review collection on integrability in the context of the AdS/CFT correspondence. In the collection we present an overview of the achievements and the status of this subject as of the year 2010.

  3. Effects of added fluids on the perception of solid food

    NARCIS (Netherlands)

    Pereira, L.J.; Wijk, de R.A.; Gaviao, M.B.D.; Bilt, van der A.


    The production of sufficient saliva is indispensable for good chewing. Recent research has demonstrated that salivary flow rate has little influence on the swallowing threshold. We examined the hypothesis that adding fluid to a food will influence the chewing process. Twenty healthy subjects chewed

  4. Development and psychometric testing of the Attitudes, Subjective Norms, Perceived Behavioural Control, and Intention to Pursue a Career in Mental Health Nursing scale. (United States)

    Wilbourn, Mark; Salamonson, Yenna; Ramjan, Lucie; Chang, Sungwon


    The aim of the present study was to develop and test the psychometric properties of the Attitudes, Subjective Norms, Perceived Behavioural Control, and Intention to Pursue a Career in Mental Health Nursing (ASPIRE) scale, an instrument to assess nursing students' intention to work in mental health nursing. Understanding the factors influencing undergraduate nursing students' career intentions might lead to improved recruitment strategies. However, there are no standardized tools to measure and assess students' intention to pursue a career in mental health nursing. The present study used a cross-sectional survey design undertaken at a large tertiary institution in Western Sydney (Australia) between May and August 2013. It comprised three distinct and sequential phases: (i) items were generated representing the four dimensions of the theory of planned behaviour; (ii) face and content validity were tested by a representative reference group and panel of experts; and (iii) survey data from 1109 first- and second-year and 619 third-year students were used in exploratory and confirmatory factor analyses to test the factorial validity of the scale. Internal consistency was measured using Cronbach's alpha. Items generated for the ASPIRE scale were subject to face and content validity testing. Results showed good factorial validity and reliability for the final 14-item scale. Principal axis factoring revealed a one-factor solution, the hypothesized model being supported by confirmatory factor analysis. The ASPIRE scale is a valid and reliable instrument for measuring intention to pursue a career in mental health nursing among Bachelor of Nursing students. © 2017 Australian College of Mental Health Nurses Inc.

  5. A randomized, controlled study of specific immunotherapy in monosensitized subjects with seasonal rhinitis: effect on bronchial hyperresponsiveness, sputum inflammatory markers and development of asthma symptoms. (United States)

    Crimi, Nunzio; Li Gotti, Fabrizio; Mangano, Giuseppe; Paolino, Giuseppina; Mastruzzo, Claudio; Vancheri, Carlo; Lisitano, Natalina; Polosa, Riccardo


    Allergic rhinitis is often associated with bronchial hyperresponsiveness (BHR) and airway inflammation, and it seems to be an important risk factor for the development of asthma. Specific immunotherapy (SIT) reduces symptoms and medication requirements in subjects with allergic rhinitis, but the mechanisms by which SIT promotes these beneficial effects are less clear. We have investigated the effects of Parietaria-SIT on rhinitis symptoms, BHR to inhaled methacholine, eosinophilic inflammation and cytokine production (interferon gamma and interleukin-4) in the sputum. The effect on asthma progression was also examined. Thirty non-asthmatic subjects with seasonal rhinitis and monosensitized to Parietaria judaica participated in a randomized, double-blind, placebo-controlled, parallel group study. Participants were randomly assigned to receive injections of a Parietaria pollen vaccine (n = 15) or matched placebo injections (n = 15) in a rapid updosing cluster regimen for 7 weeks, followed by monthly injections for 34 months. Throughout the 3-year study we collected data on symptoms and medication score, airway responsiveness to methacholine, eosinophilia and soluble cytokines in sputum, followed by a complete evaluation of the clinical course of atopy. Hay fever symptom and medication scores were well controlled by SIT. By the end of the study, in the placebo group, symptom and medication scores significantly increased by a median (interquartile range) of 121% (15-280%) and 263% (0-4400%) respectively (p Parietaria-SIT is effective in controlling hay fever symptoms and rescue medications, but no changes in the BHR to methacholine or sputum eosinophilia were observed. Moreover, Parietaria-SIT appears to prevent the natural progression of allergic rhinitis to asthma, suggesting that SIT should be considered earlier in the management of this condition.

  6. Strain-hardening behavior and microstructure development in polycrystalline as-cast Mg-Zn-Y alloys with LPSO phase subjected to cyclic loading

    Energy Technology Data Exchange (ETDEWEB)

    Shiraishi, Kazuma [Department of Materials Science and Engineering, Kumamoto University, 2-39-1, Kurokami, Chuo-ku, Kumamoto 860-8555 (Japan); Mayama, Tsuyoshi, E-mail: [Priority Organization for Innovation and Excellence, Kumamoto University, 2-39-1, Kurokami, Chuo-ku, Kumamoto 860-8555 (Japan); Department of Materials Science and Engineering, University of Virginia, Charlottesville, VA 22904 (United States); Yamasaki, Michiaki [School of Mechanical and Mining Engineering, The University of Queensland, St Lucia, Brisbane, Qld 4072 (Australia); Magnesium Research Center/Department of Materials Science and Engineering, Kumamoto University, 2-39-1, Kurokami, Chuo-ku, Kumamoto 860-8555 (Japan); Kawamura, Yoshihito [Magnesium Research Center/Department of Materials Science and Engineering, Kumamoto University, 2-39-1, Kurokami, Chuo-ku, Kumamoto 860-8555 (Japan)


    The strain-hardening behavior and microstructural development of polycrystalline as-cast Mg-Zn-Y alloys with various volume fractions of the long-period stacking ordered (LPSO) phase subjected to cyclic loading were experimentally evaluated. For all alloys, cyclic loading tests with a constant strain amplitude of 0.5% for up to 100 cycles showed asymmetric cyclic hardening behavior. That is, the absolute value of the compressive peak stress significantly increased during cyclic loading while the tensile peak stress slightly decreased. With increasing volume fraction of the LPSO phase, the stress amplitude significantly increased. Cyclic loading tests after compressive preloading up to 200 or 250 MPa resulted in a significant increase in the stress amplitude, while a number of kink bands developed during preloading. For the cyclic hardening behavior, the contribution of the increase in kinematic hardening was significant in the alloys with a higher volume fraction of the LPSO phase. Transmission electron microscopy observation of the cyclically deformed Mg{sub 85}Zn{sub 6}Y{sub 9} alloy indicated the formation of a deformation-induced band, where the crystal structure was transformed from 18R-LPSO to hcp-Mg with the exclusion of solute elements.

  7. The role of professor V. I. Dolotsky in the development of Lliturgics as science and academic subject in Russian higher Church education

    Directory of Open Access Journals (Sweden)

    Nikolai Karamyshev


    Full Text Available This paper is devoted to one of the key moments in liturgical studies in Russian higher church education. This moment was outwardly marked by the introduction of the new term “liturgics” instead of the old term “church antiquities” in the 1840s. The article shows the role of Professor Dolotsky in the development of liturgics as a science and an academic subject. Based on the analysis of survived manuscript documents, lithoprinted lecture notes and papers, we demonstrate that the introduction of the term “liturgics” at Saint-Petersburg Theological Academy in 1849–1853 and its following adoption in higher church education took place with a direct involvement of V. I. Dolotsky. Employing historical approach, Dolotsky signifi cantly broadened the content of his course of lectures, supplementing it with historical data. Dolotsky’s scholarly interests can be identifi ed on the basis of his articles, academic course programmes and lithoprinted lecture notes. They were related, above all, to text analysis of variable parts of church service, particularly holiday service. Besides, Dolotsky expressed interest in the origin of Holy days and their orders in antiquity. Here, by means of the historical approach, Dolotsky made use of the evidence of ancient Holy Fathers and emphasised the importance of employing liturgical sources of heterodox confessions that had common origins with the Orthodox Church. Thus, Dolotsky came to be the first Russian scholar of liturgics and provided a foundation for the further development of historical liturgics in Russian theological science.

  8. Subject (of documents)

    DEFF Research Database (Denmark)

    Hjørland, Birger


    such as concepts, aboutness, topic, isness and ofness are also briefly presented. The conclusion is that the most fruitful way of defining “subject” (of a document) is the documents informative or epistemological potentials, that is, the documents potentials of informing users and advance the development......This article presents and discuss the concept “subject” or subject matter (of documents) as it has been examined in library and information science (LIS) for more than 100 years. Different theoretical positions are outlined and it is found that the most important distinction is between document......-oriented views versus request-oriented views. The document-oriented view conceive subject as something inherent in documents, whereas the request-oriented view (or the policy based view) understand subject as an attribution made to documents in order to facilitate certain uses of them. Related concepts...

  9. Quantum Black Holes as Holograms in AdS Braneworlds

    CERN Document Server

    Emparan, R; Kaloper, Nemanja; Emparan, Roberto; Fabbri, Alessandro; Kaloper, Nemanja


    We propose a new approach for using the AdS/CFT correspondence to study quantum black hole physics. The black holes on a brane in an AdS$_{D+1}$ braneworld that solve the classical bulk equations are interpreted as duals of {\\it quantum-corrected} $D$-dimensional black holes, rather than classical ones, of a conformal field theory coupled to gravity. We check this explicitly in D=3 and D=4. In D=3 we reinterpret the existing exact solutions on a flat membrane as states of the dual 2+1 CFT. We show that states with a sufficiently large mass really are 2+1 black holes where the quantum corrections dress the classical conical singularity with a horizon and censor it from the outside. On a negatively curved membrane, we reinterpret the classical bulk solutions as quantum-corrected BTZ black holes. In D=4 we argue that the bulk solution for the brane black hole should include a radiation component in order to describe a quantum-corrected black hole in the 3+1 dual. Hawking radiation of the conformal field is then ...

  10. Attitudes Toward Alzheimer's Care-Seeking Among Korean Americans: Effects of Knowledge, Stigma, and Subjective Norm. (United States)

    Casado, Banghwa Lee; Hong, Michin; Lee, Sang E


    Early detection of Alzheimer's disease (AD) ensures that affected individuals and their caregivers can make appropriate plans for health care needs, yet many ethnic minorities delay seeking care for AD until the disease has progressed. This study examined attitudes toward care-seeking for AD among Korean Americans (KAs) and identified factors affecting their attitudes. A cross-sectional survey was used to collect data from 234 KA adults. We conducted hierarchical regression analyses to examine the effects of sociocultural background (age, gender, education, cultural orientation), AD knowledge and exposure to AD, and beliefs about AD (stigma of pity, shame, and public avoidance) and AD care (subjective norm) on KAs' attitudes toward seeking AD care from primary care physicians (PCPs) and AD specialists. We also tested whether knowledge of AD moderated the impact of beliefs about AD and AD care on KAs' attitudes toward seeking AD care. For both PCPs and AD specialists, the subjective norm had the strongest effect on KAs' attitudes toward care seeking (β = 0.557 for PCPs, β = 0.360 for specialists). Effects of stigma beliefs disappeared in the presence of the subjective norm. AD knowledge moderated the impact of the subjective norm on the attitudes toward both PCPs (β = -1.653) and specialists (β = -1.742). The significance of the subjective norm in KAs' attitudes toward AD care-seeking underscores the importance of public education, and our study suggests that increasing AD knowledge could facilitate a change in public attitudes toward seeking AD care.

  11. Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials. (United States)

    Weiner, Michael W; Veitch, Dallas P; Aisen, Paul S; Beckett, Laurel A; Cairns, Nigel J; Green, Robert C; Harvey, Danielle; Jack, Clifford R; Jagust, William; Morris, John C; Petersen, Ronald C; Saykin, Andrew J; Shaw, Leslie M; Toga, Arthur W; Trojanowski, John Q


    The Alzheimer's Disease Neuroimaging Initiative (ADNI) has continued development and standardization of methodologies for biomarkers and has provided an increased depth and breadth of data available to qualified researchers. This review summarizes the over 400 publications using ADNI data during 2014 and 2015. We used standard searches to find publications using ADNI data. (1) Structural and functional changes, including subtle changes to hippocampal shape and texture, atrophy in areas outside of hippocampus, and disruption to functional networks, are detectable in presymptomatic subjects before hippocampal atrophy; (2) In subjects with abnormal β-amyloid deposition (Aβ+), biomarkers become abnormal in the order predicted by the amyloid cascade hypothesis; (3) Cognitive decline is more closely linked to tau than Aβ deposition; (4) Cerebrovascular risk factors may interact with Aβ to increase white-matter (WM) abnormalities which may accelerate Alzheimer's disease (AD) progression in conjunction with tau abnormalities; (5) Different patterns of atrophy are associated with impairment of memory and executive function and may underlie psychiatric symptoms; (6) Structural, functional, and metabolic network connectivities are disrupted as AD progresses. Models of prion-like spreading of Aβ pathology along WM tracts predict known patterns of cortical Aβ deposition and declines in glucose metabolism; (7) New AD risk and protective gene loci have been identified using biologically informed approaches; (8) Cognitively normal and mild cognitive impairment (MCI) subjects are heterogeneous and include groups typified not only by "classic" AD pathology but also by normal biomarkers, accelerated decline, and suspected non-Alzheimer's pathology; (9) Selection of subjects at risk of imminent decline on the basis of one or more pathologies improves the power of clinical trials; (10) Sensitivity of cognitive outcome measures to early changes in cognition has been improved and

  12. Entanglement Entropy of AdS Black Holes

    Directory of Open Access Journals (Sweden)

    Maurizio Melis


    Full Text Available We review recent progress in understanding the entanglement entropy of gravitational configurations for anti-de Sitter gravity in two and three spacetime dimensions using the AdS/CFT correspondence. We derive simple expressions for the entanglement entropy of two- and three-dimensional black holes. In both cases, the leading term of the entanglement entropy in the large black hole mass expansion reproduces exactly the Bekenstein-Hawking entropy, whereas the subleading term behaves logarithmically. In particular, for the BTZ black hole the leading term of the entanglement entropy can be obtained from the large temperature expansion of the partition function of a broad class of 2D CFTs on the torus.

  13. Sputnik: ad hoc distributed computation. (United States)

    Völkel, Gunnar; Lausser, Ludwig; Schmid, Florian; Kraus, Johann M; Kestler, Hans A


    In bioinformatic applications, computationally demanding algorithms are often parallelized to speed up computation. Nevertheless, setting up computational environments for distributed computation is often tedious. Aim of this project were the lightweight ad hoc set up and fault-tolerant computation requiring only a Java runtime, no administrator rights, while utilizing all CPU cores most effectively. The Sputnik framework provides ad hoc distributed computation on the Java Virtual Machine which uses all supplied CPU cores fully. It provides a graphical user interface for deployment setup and a web user interface displaying the current status of current computation jobs. Neither a permanent setup nor administrator privileges are required. We demonstrate the utility of our approach on feature selection of microarray data. The Sputnik framework is available on Github under the Eclipse Public License. or Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail:

  14. Value adding management: A concept and a case

    DEFF Research Database (Denmark)

    Jensen, Per Anker; Katchamart, Akarapong


    Purpose: To develop a management concept that can assist facilities managers in implementing value adding strategies and practices. The FM Value Map has been developed to analyse and demonstrate the different ways FM can add value. However, there is a need to develop management tools that can...... be used more directly and proactively by facilities managers to implement adding value strategies and practices. Methodology: The development of the concept of Value Adding Management is based on the management model for FM included in the European FM standards, recent theories on added value of FM...... and real estate and the related concept of Value Management from building projects. The chapter outlines a preliminary theoretical based management concept, which is investigated, tested and discussed based on a case study of LEGO. Findings: The case study provides a clear example of a company that actual...

  15. Research and technological development in the subject of the wind power generation; Investigacion y desarrollo tecnologico en el tema de la generacion eoloelectrica

    Energy Technology Data Exchange (ETDEWEB)

    Borja Diaz, Marco A.; Gonzalez Galarza, Raul [Instituto de Investigaciones Electricas, Temixco, Morelos (Mexico)


    The wind power technology has advanced in an important way during the last decade. In the industrialized countries the annual sales of aero generators reach surprising numbers and increase annually at a rate of 30%. But, is this the direct product of the maturity of this technology?, is at the moment the wind power technology economically competitive with the conventional options? Do necessities exist of Research and Technological Development in the subject? This article presents some facts and indicators that will help the reader to deduce his own conclusions. [Spanish] La tecnologia eoloelectrica ha avanzado de manera importante durante la ultima decada. En los paises industrializados las ventas anuales de aerogeneradores alcanzan cifras sorprendentes y se incrementan al 30% anual. Pero, es esto el producto directo de la madurez de esta tecnologia?, actualmente la tecnologia eoloelectrica es economicamente competitiva con las opciones convencionales?, existen necesidades de Investigacion y Desarrollo Tecnologico en el tema? Este articulo presenta algunos hechos e indicadores que ayudaran al lector a deducir sus propias conclusiones.

  16. Brain development in male rats subjected to early weaning and treated with diet containing flour or flaxseed oil after 21 days until 60 days. (United States)

    Pessanha, C R; da Camara Boueri, B Ferolla; da Costa, L Rodrigues; Ferreira, M Rocha; Melo, H Saldanha; de Abreu, M Duque Coutinho; Pessoa, L Rozeno; da Silva, P C Alves; Pereira, A D'Avila; Ribeiro, D Cavalcante; de Meneses, J Azevedo; da Costa, C A Soares; Boaventura, G T


    The precocious interruption of lactation is a prime factor for developmental plasticity. Here we analyzed whether flour or flaxseed oil treatment contributes to body and brain mass in male rats subjected to early weaning. Pups were weaned for separation from their mother at 14 (early weaning, EW) and 21 days (control, C). At 21 days, some of the pups were evaluated (C21 v. EW21). After 21 days, control pups (C60) were fed a control diet. EW pups were divided into those fed a control diet (EWC60), those given flaxseed flour (EWFF60), and those given flaxseed oil (EWFO60) until 60 days. EW21 showed lower body and absolute brain mass and higher relative brain mass. At 60 days, EWC60 and EWFO60 had lower body mass. With regard to relative brain mass, EWC60 was heavier; EWFO60 had lower values compared with EWC60 and higher values compared with C60 and EWFF60. These results indicated that flaxseed flour, in comparison with flaxseed oil, contributes to brain development after EW.

  17. Left and right reaction time differences to the sound intensity in normal and AD/HD children. (United States)

    Baghdadi, Golnaz; Towhidkhah, Farzad; Rostami, Reza


    Right hemisphere, which is attributed to the sound intensity discrimination, has abnormality in people with attention deficit/hyperactivity disorder (AD/HD). However, it is not studied whether the defect in the right hemisphere has influenced on the intensity sensation of AD/HD subjects or not. In this study, the sensitivity of normal and AD/HD children to the sound intensity was investigated. Nineteen normal and fourteen AD/HD children participated in the study and performed a simple auditory reaction time task. Using the regression analysis, the sensitivity of right and left ears to various sound intensity levels was examined. The statistical results showed that the sensitivity of AD/HD subjects to the intensity was lower than the normal group (p  0.05). However, in control group the left pathway was more sensitive to the sound intensity level than the right one (p = 0.0156). It can be probable that the deficit of the right hemisphere has influenced on the auditory sensitivity of AD/HD children. The possible existent deficits of other auditory system components such as middle ear, inner ear, or involved brain stem nucleuses may also lead to the observed results. The development of new biomarkers based on the sensitivity of the brain hemispheres to the sound intensity has been suggested to estimate the risk of AD/HD. Designing new technique to correct the auditory feedback has been also proposed in behavioral treatment sessions. Copyright © 2017. Published by Elsevier B.V.

  18. ADS-B- Automatic Dependent Surveillance- Broadcast

    Directory of Open Access Journals (Sweden)

    Borivoj Galović


    Full Text Available The CU/Tent system of air traffic is facing many drawbacksand problems that restrict its further development and makes itdifficult to follow the trends of increase in the traffic volume.By means of their technology, the systems such as ADS-8create rhe basis for further building, upgrading, improving anddeveloping of a completely new concept of the air traffic system.Through their functions they fully fit into and support the basicfunctions of communication, navigation and swveillancewhich form the basis of the new concept that needs to be implementedas soon as possible.

  19. Green Skills as an Added-Value Element in Producing Competent Students


    Arasinah Kamis; Ramlee Mustapha; Norwaliza Abdul Wahab; Bushra Limuna Hj Ismail


    Green skills model is developed as a reference for implementing green skills in the learning process for primary school students. Elements of green skills need to be applied as early as possible in students to produce citizens who are competent in all aspects and foremost to maintain the environmental balance. Elements of green skills can be used as a value-added in any subject and as a cross-curricular element such as Design and Technology (D&T). Research shows that the country is now passin...

  20. The added value of virtual reality technology and force feedback for surgical training simulators. (United States)

    Zhang, L; Grosdemouge, C; Arikatla, V S; Ahn, W; Sankaranarayanan, G; De, S; Jones, D; Schwaitzberg, S; Cao, C G L


    Laparoscopic surgery requires more specialized training of the surgeons than traditional open surgery. The Virtual Basic Laparoscopic Surgical Trainer (VBLaST) is being developed as a virtual version of the Fundamentals of Laparoscopic Skills (FLS) trainer. This study assessed the current haptic and virtual reality (VR) technology of a virtual peg transfer task of the VBLaST, based on the subjective preference of surgeons and their objective task performance measures. Twenty-one surgical residents, fellows and attendings performed a peg-transfer task in the FLS and the VBLaST. Each subject performed 10 trials on each simulator. Results showed that subjects performed significantly better on the FLS than on the VBLaST. Subjects showed a significant learning effect on both simulators, but with an accelerated improvement on the VBLaST. Even so, 81% of the subjects preferred the FLS over the VBLaST for surgical training which could be attributed to the novelty of the VR technology and existing deficiencies of the haptic interface. Despite the subjective preference for the physical simulator, the performance results indicate an added value of VR and haptics in surgical training, which is expected to be demonstrated in more surgically relevant tasks such as suturing and knot-tying.

  1. A reference accelerator scheme for ADS applications (United States)

    Biarrotte, Jean-Luc; Bousson, Sébastien; Junquera, Tomas; Mueller, Alex C.; Olivier, Aurélia


    Accelerator Driven Systems (ADS) for transmutation of nuclear waste typically require 350 MeV-1 GeV accelerators delivering proton fluxes of 5-10 mA for demonstrators, and 20-50 mA for large industrial systems. Thus, such machines belong to the category of the so-called HPPA (High-Power Proton Accelerators), with multi-megawatt beam power. HPPA are presently developed and constructed at great pace for their broad utility in fundamental or applied science. Compared to other HPPA, many features and requirements are similar for the ADS driver. However, there is a need for exceptional reliability: because of the induced thermal stress to the sub-critical core, the number of unwanted "beam-trips" should not exceed a few per year, a requirement that is several orders of magnitude above usual performance. Consecutive to the work of the European Technical Working Group (ETWG) on ADS, the Preliminary Design Study of an Experimental ADS (PDS-XADS) was launched in 2001 as a 5th Framework Program EC project. A special Working Package (WP3) was dedicated to the accelerator design, taking especially into account that the issue of "beam-trips" could be a potential "show-stopper" for ADS technology in general. A reference solution, based on a linear superconducting accelerator with its associated doubly achromatic beam line, has been worked out to some detail. For high reliability, the proposed design is intrinsically fault tolerant, relying on highly modular "de-rated" components associated to a fast digital feedback system. The proposed solution also appears to be robust concerning operational aspects like maintenance and radioprotection. A roadmap for construction as well as the required consolidated budget was elaborated. A program for the remaining R&D, focused on experimental reliability demonstration of prototypical components has been elaborated. This R&D will be performed in the 6th Framework Program EC project EUROTRANS, which presently is just starting. EC Contract No

  2. Ad valorem versus unit taxes

    DEFF Research Database (Denmark)

    Schröder, Philipp J.H.; Sørensen, Allan


    Real-world industries are composed from heterogeneous firms and substantial intra-industry reallocations take place, i.e. high productivity firms squeeze out low productivity firms. Previous tax-tool comparisons have not included these central forces of industry structure. This paper examines...... a general equilibrium monopolistic competition model with heterogeneous firms and intra-industry reallocations. We show that the welfare superiority of ad valorem over unit taxes under imperfect competition is not only preserved but amplified. The additional difference between the tools arises because unit...... taxes distort relative prices, which in turn reduces average industry productivity through reallocations (the survival and increased market share of lower productivity firms). Importantly, numerical solutions of the model reveal that the relative welfare loss from using the unit tax increases...

  3. Topological AdS/CFT (United States)

    Genolini, Pietro Benetti; Richmond, Paul; Sparks, James


    We define a holographic dual to the Donaldson-Witten topological twist of N=2 gauge theories on a Riemannian four-manifold. This is described by a class of asymptotically locally hyperbolic solutions to N=4 gauged supergravity in five dimensions, with the four-manifold as conformal boundary. Under AdS/CFT, minus the logarithm of the partition function of the gauge theory is identified with the holographically renormalized supergravity action. We show that the latter is independent of the metric on the boundary four-manifold, as required for a topological theory. Supersymmetric solutions in the bulk satisfy first order differential equations for a twisted Sp(1) structure, which extends the quaternionic Kähler structure that exists on any Riemannian four-manifold boundary. We comment on applications and extensions, including generalizations to other topological twists.

  4. Developer


    Lakew, Lakachew


    As companies grow managing the work becomes harder and harder, thus the ad-vantages of technology come into hand for increasing communication and facili-tating work. This thesis documents the design and development of a web and mobile applica-tion for a service company. The web and mobile applications are built using Laravel and Android Studio respectively. These two applications are designed to communicate with one another so that similar data can be used across these two platforms. ...

  5. Microstructural development and superconducting properties of BaO{sub 2}-added Bi{sub 2}Sr{sub 2}CaCu{sub 2}O{sub 8+x}.

    Energy Technology Data Exchange (ETDEWEB)

    Koritala, R. E.; Trociewitz, U. P.; Bacaltchuk, C.; Schwartz, J.; Sahm, P. R.; Brandao, L.


    Investigations on the effects of Ba additions in Bi-2212 superconductors are focused on compositional, microstructural, and magnetization studies. In previous studies, we showed that BaO{sub 2} reacts with Bi-2212 to form second phases. Zero-field and in-field transport properties in Ag-clad BaO{sub 2} added Bi-2212 tapes had been improved at 4.2 K [1]-[3]. SEM micrographs, pole figures, and transport critical currents versus magnetic field orientation suggest that BaO{sub 2} has a strong influence on the microstructural properties. Magnetization studies revealed that BaO{sub 2} does not affect the pinning properties of optimally added Bi-2212. To estimate the potential of BaO{sub 2} additions in creating possible pinning sites, TEM investigations were carried out focusing on sub-micrometer inclusions and growth defects in the superconducting phase.

  6. Personal Notification Service from the ADS Abstract Service (United States)

    Eichhorn, Guenther


    The ADS provides a search system for over 4 million records. The data are organized in 4 databases, Astronomy/Planetary Sciences, Physics/Geophysics, Instrumentation, and ArXiv Preprints. The ADS is a NASA funded project and is free to use for everybody world-wide. We have recently implemented a new version of the ADS notification system ``myADS.'' This system allows our users to specify, for each of the 4 databases, an author query and two subject matter queries. These queries are executed whenever the databases are updated, and the results are emailed to the user. This system makes it very easy to keep up-to-date with the literature in Astronomy and Physics, as well as the preprint ArXiv. We plan to offer this capability in collaboration with the preprint ArXiv to the users of the preprints, to allow for a more customized notification system for new preprints. The ADS can be accessed at

  7. Improved Functionality and Curation Support in the ADS (United States)

    Accomazzi, Alberto; Kurtz, Michael J.; Henneken, Edwin A.; Grant, Carolyn S.; Thompson, Donna; Chyla, Roman; Holachek, Alexandra; Sudilovsky, Vladimir; Murray, Stephen S.


    In this poster we describe the developments of the new ADS platform over the past year, focusing on the functionality which improves its discovery and curation capabilities.The ADS Application Programming Interface (API) is being updated to support authenticated access to the entire suite of ADS services, in addition to the search functionality itself. This allows programmatic access to resources which are specific to a user or class of users.A new interface, built directly on top of the API, now provides a more intuitive search experience and takes into account the best practices in web usability and responsive design. The interface now incorporates in-line views of graphics from the AAS Astroexplorer and the ADS All-Sky Survey image collections.The ADS Private Libraries, first introduced over 10 years ago, are now being enhanced to allow the bookmarking, tagging and annotation of records of interest. In addition, libraries can be shared with one or more ADS users, providing an easy way to collaborate in the curation of lists of papers. A library can also be explicitly made public and shared at large via the publishing of its URL.In collaboration with the AAS, the ADS plans to support the adoption of ORCID identifiers by implementing a plugin which will simplify the import of papers in ORCID via a query to the ADS API. Deeper integration between the two systems will depend on available resources and feedback from the community.

  8. Superstring Theory In Ads(3) And Plane Waves

    CERN Document Server

    Son, J S


    This thesis is devoted to the study of string theory in AdS 3 and its applications to recent developments in string theory. The difficulties associated with formulating a consistent string theory in AdS3 and its underlying SL(2, R) WZW model are explained. We describe how these difficulties can be overcome by assuming that the SL(2, R) WZW model contains spectral flow symmetry. The existence of spectral flow symmetry in the fully quantum treatment is proved by a calculation of the one-loop string partition function. We consider Euclidean AdS 3 with the time direction periodically identified, and compute the torus partition function in this background. The string spectrum can be reproduced by viewing the one-loop calculation as the free energy of a gas of strings, thus providing a rigorous proof of the results based on spectral flow arguments. Next, we turn to spacetimes that are quotients of AdS 3, which include the BTZ black hole and conical spaces. Strings propagating in the conical space are described by...

  9. Subjectivity and professional vocational counselling


    Müller, Marina


    In this work, I shall deal with the psychodynamic approach to subjectivity in P.V.C. To this effect, I want to develop the concept of subject and subjectivity, its variation and historical-social construction and its approach in counselling, from a psychodynamic conceptual framework in P.V.C. with a short reference to the theoretical sources on which this approach is founded. Departamento de Psicología

  10. III Adli Bilimler Kongresi - Posterler

    Directory of Open Access Journals (Sweden)

    Adli Tıp Uzmanları Derneği ATUD


    Full Text Available POSTER ÖZETLERİ OTOPSİ UYGULAMASINA TOPLUMSAL YAKLAŞIM C. Haluk İNCE*, Nurhan İNCE** ***, Şebnem Korur FİNCANCI*, Yıldız TÜMERDEM**. ÖZET Otopsi sayısı, bir ülkenin sağlık ve yargı yönünden gelişmişliğinin kriterlerinden biridir. Çalışma bireylerin konu ile ilgili bilgi ve davranışları öğrenildiği takdirde otopsi ile ilgili olumsuz davranışlarının da en aza indirgenecek bir yöntemle eğitilmelerinin sağlanabileceği savı ile gerçekleştirilmiştir. Verileri İstanbul kentinde farklı sosyoekonomik kültürel (SEK düzeyli toplum yapısının gözlendiği ilçelerden rastlantısal örnekleme ile seçilen 342 katılıcıdan çok sorulu anketi (ön seçimli yüzyüze uygulama yöntemi ile toplanmıştır. 342 katılımcının %6l.4 (n=210'ü kadın, %38.6 (n=132'si erkektir. % 9.1 kişinin ailesinde bir otopsi deneyimi yaşamıştır. %76.9 (n:263 kişi otopsinin gerekli olduğunu ifade etmiştir. Bireylerin eğitim durumlarına göre otopsiye izin verme konusundaki görüşlerinin arasında öğrenim düzeyi yüksek olanların lehine istatistiksi açıdan anlamlı sonuç çıkmıştır. Her iki cinste de ailelerinde hangi birey olursa olsun otopsiye rıza konusundaki görüşlerinde farklılığın olmaması dikkat çekici bulunmuştur. % 16.1 (n:5' i ise dini inançlarına aykırı olduğu için otopsiye asla izin veremeyeceklerini ifade etmiştir. Toplumun SEK yapısından kaynaklanan yetersiz bilgi ülkemizdeki otopsi sayısının gelişmiş ülkelere oranla olumsuz etkilemektedir. Ancak hekim ve hekim dışı sağlık çalışanlarının da otopsi konusunda bilgi ve donanımlarını geliştirmeleri gerekmektedir. Bu çalışma otopsi sayısındaki düşüklüğün rolünü araştırmak üzere düzenlenmiştir. Anahtar Kelimeler: Otopsi, toplumsal yargı, bilgilendirme. TRAKTÖR KAZALARINDA ÖLEN OLGULARIN DEĞERLENDİRİLMESİ M.Selim ÖZKÖK*, Ufuk KATKICI. ÖZET Trafik kazaları adli tıp pratiğinde


    Directory of Open Access Journals (Sweden)

    Viktoria Shcherbatiuk


    Full Text Available The author of the article analyzes the methodology of using a number of creative tasks for working with students of Philology Department during the practical sessions of literary subjects. The tasks are focused on designing the creative qualities of future language and literature teachers: imagination, inspiration, initiative, noncommonality, extraordinary nature, his/her own point of view. At present, the students perceive the learning process as something fixed, which necessarily must be studied and passed. They will not think critically, as long as the teacher does not create creative atmosphere to facilitate the active involvement of students into the learning process. And one should allow them to freely speculate, dream up. Each person has the potential of skills, and the tasks of modern teacher are developing these skills and managing the process of the development. Therefore, the main purpose of organization of practical session is to be able to encounter the students’ intellectual forces, to cause them to work, to create a favorable pedagogical environment for their formation and simultaneously to shape the identity of a young person, his/her outlook. Organizing the practical training one should find a way to students’ minds and doesn`t give them ready knowledge but to ensure them to acquire knowledge themselves trying to search, establish dependences, and patterns. They should be engaged in creative dialogue with cultural texts and nourish their own personal position. The problem of creativity is complex and multifaceted. Since ancient times it has been in the scholars’ and philosophers’ field of view (Plato, Aristotle, Hegel, Pestalozzi, etc.. Basic issues of a creative individual are disclosed in the works by A. Luk, Ia. Ponomarev, A. Matiushkin, P. Enhelmeier, V. Moliako, O. Amatev, E. Belkina, A. Bohush, N. Vetluhina, N. Havrish, O. Dronova and others. However, the growing relevance and educational significance of this issue

  12. Interaction, transference, and subjectivity

    DEFF Research Database (Denmark)

    Lundgaard Andersen, Linda


    Fieldwork is one of the important methods in educational, social, and organisational research. In fieldwork, the researcher takes residence for a shorter or longer period amongst the subjects and settings to be studied. The aim of this is to study the culture of people: how people seem to make...... sense of their lives and which moral, professional, and ethical values seem to guide their behaviour and attitudes. In fieldwork, the researcher has to balance participation and observation in her attempts at representation. Consequently, the researcher’s academic and life-historical subjectivity...... are important filters for fieldwork. In general, fieldwork can be understood as processes where field reports and field analysis are determined by how the researcher interacts with and experiences the field, the events and informants in it, and how she subsequently develops an ethnography. However, fieldwork...

  13. The Subject in Cognitive Psychotherapy

    Directory of Open Access Journals (Sweden)

    Isabel Caro-Gabalda


    Full Text Available This paper discusses the various subjects embedded in cognitive psychotherapy. The cognitive model developed by Beck, considered as a rationalist and modernist model, will exemplify these subjects. Cognitive therapy should be placed in the modernist historical context and related to a subject characterized as having rationality and the ability to observe and detect cognitions, emotions and behaviors. The paper develops this background introducing three main subject types. The first is the introspective and conscious subject, who is able to observe what is within oneself, has free access, and is conscious of one's cognitive world. The second is the cognitive miser that describes the subject who enters into therapy. The final subject identified, is the trained scientist who is able to develop a more objective knowledge, changing faulty schemas and cognitive distortions. This subject is the one most looked for in cognitive therapy. We could connect these subjects to some of the main elements of cognitive therapy such as the concept of ABC, assessment procedures, cognitive techniques or the relevance of schemas. Finally, the paper suggests some issues for study that could contribute to the theoretical and clinical evolution of cognitive psychotherapy.

  14. Estimating Free and Added Sugar Intakes in New Zealand. (United States)

    Kibblewhite, Rachael; Nettleton, Alice; McLean, Rachael; Haszard, Jillian; Fleming, Elizabeth; Kruimer, Devonia; Te Morenga, Lisa


    The reduction of free or added sugar intake (sugars added to food and drinks as a sweetener) is almost universally recommended to reduce the risk of obesity-related diseases and dental caries. The World Health Organisation recommends intakes of free sugars of less than 10% of energy intake. However, estimating and monitoring intakes at the population level is challenging because free sugars cannot be analytically distinguished from naturally occurring sugars and most national food composition databases do not include data on free or added sugars. We developed free and added sugar estimates for the New Zealand (NZ) food composition database (FOODfiles 2010) by adapting a method developed for Australia. We reanalyzed the 24 h recall dietary data collected for 4721 adults aged 15 years and over participating in the nationally representative 2008/09 New Zealand Adult Nutrition Survey to estimate free and added sugar intakes. The median estimated intake of free and added sugars was 57 and 49 g/day respectively and 42% of adults consumed less than 10% of their energy intake from free sugars. This approach provides more direct estimates of the free and added sugar contents of New Zealand foods than previously available and will enable monitoring of adherence to free sugar intake guidelines in future.

  15. Hypothetical atopic dermatitis-myeloproliferative neoplasm (AD-MPN syndrome

    Directory of Open Access Journals (Sweden)

    Toshiaki eKawakami


    Full Text Available Atopic dermatitis (AD is a chronic inflammatory skin disease. Myeloproliferative neoplasms (MPNs are hematopoietic malignancies caused by uncontrolled proliferation of hematopoietic stem/progenitor cells. Recent studies have described several mutant mice exhibiting both AD-like skin inflammation and MPN. Common pathways for skin inflammation encompass overexpression of thymic stromal lymphopoietin and reduced signaling of epidermal growth factor receptor in the epidermis, while overproduction of granulocyte-colony stimulating factor by keratinocytes and constitutive activation of Stat5 in hematopoietic stem cells are important for the development of MPN. The murine studies suggest the existence of a similar human disease tentatively termed the AD-MPN syndrome.

  16. Influence of Antibiotics Added in Milk over Yogurth Quality

    Directory of Open Access Journals (Sweden)

    Cornelia Vintila


    Full Text Available Large spectrum antibiotics used in different cow diseases leads to their release in milk altering its proprieties during processing. Knowing the inhibitory effect of antibiotics upon lactic bacteria development and multiplying we followed the effect of gentamycin, a large spectrum antibiotic added in different doses in milk used for yogurth processing. In our research, besides the effect of antibiotica we followed also the influence of milk fat content upon milk clotting time, while antibiotics added in milk incease the clotting time of yogurth. Clotting density deceases proportional with the dosis of antibiotics added to milk.

  17. Recurring Anomaly Detection System (ReADS) (United States)

    National Aeronautics and Space Administration — Overview: ReADS can analyze text reports, such as aviation reports and problem or maintenance records. ReADS uses text clustering algorithms to group loosely related...

  18. A study on the preparation of value-added products from the nonmetallic minerals

    Energy Technology Data Exchange (ETDEWEB)



    This report consists of 4 subjects. (1) preparation of value-added products for limestone : The purpose of this study is to develop the process of grade up by economical processes with low and/or middle grade of domestic limestone and of powder coating by dry base. In this year, first of all, we investigated the status of application utilize and related industries with the domestic limestone, and then being consideration with condition selected the adequate sample from Taeback, Uljin, Andong, Jungsun and Kumsan area. (2) development of value added technology of pyrophyllite ore : Considering the value added technology for pyrophyllite ore, the study was carried out for development of manufacturing technology to produce paint's filler from pyrophyllite ore reserved at Bunam mine in Cheongsong, Kyungsangbuk-do. The objective of the study is to develop a technology for not only creating an added value of pyrophyllite but also substituting the imported pyrophyllite product. (3) manufacturing technology of materials for fine chemical and electronic industry use : For use high electrically conductive film and advanced high functional solid lubricant, add new and advanced high functional propertied to fine graphite powder through surface modification with gas and organic materials. In this year, scale up test(30 l/batch) were carried out to stand firm the process of graphite surface control and modification for mass produce and to appraise characteristics of surface modified graphite powders. To arrange in order the test sample for actual apply in related company. (4) manufacturing technology of materials for fine chemical industry use (sericite, muscovite) : During the past three years, we studied on the processing technology and treatment process for recovery of concentrated sericite and muscovite, fine grinding characterization and classification of purified sericite and muscovite and the basic study of surface modification which are used as a source material of



    Beata Skowron-Grabowska


    In the paper, the author has shown possibilities of creating added value in logistics centre from the theoretical point of view. Value creation in the supply literature commonly builds on the added value models One of such possibilities is preparing hierarchical model of creating added value through prediction of customers’ and enterprises’ in supply chain expectations. Another possibility pointed in the paper is creation of added value due to building special department of transportation and...

  20. Effective ads: new technology answers old questions

    NARCIS (Netherlands)

    L.E. Couwenberg (Linda)


    markdownabstractMarketing experts commonly refer to ads as either “emotional” or “rational” in their appeal to consumers. This dichotomy of “thinking versus feeling” is most evident when it comes to discussions around what makes an ad effective. Some studies suggest that an ad that pulls on the

  1. Automated Experiments on Ad Privacy Settings

    Directory of Open Access Journals (Sweden)

    Datta Amit


    Full Text Available To partly address people’s concerns over web tracking, Google has created the Ad Settings webpage to provide information about and some choice over the profiles Google creates on users. We present AdFisher, an automated tool that explores how user behaviors, Google’s ads, and Ad Settings interact. AdFisher can run browser-based experiments and analyze data using machine learning and significance tests. Our tool uses a rigorous experimental design and statistical analysis to ensure the statistical soundness of our results. We use AdFisher to find that the Ad Settings was opaque about some features of a user’s profile, that it does provide some choice on ads, and that these choices can lead to seemingly discriminatory ads. In particular, we found that visiting webpages associated with substance abuse changed the ads shown but not the settings page. We also found that setting the gender to female resulted in getting fewer instances of an ad related to high paying jobs than setting it to male. We cannot determine who caused these findings due to our limited visibility into the ad ecosystem, which includes Google, advertisers, websites, and users. Nevertheless, these results can form the starting point for deeper investigations by either the companies themselves or by regulatory bodies.

  2. Contextual advertising using Google AdWords and Google AdSense


    Mihok, Radovan


    The thesis introduces contextual advertising on internet using Google AdWords. The paper describes individual steps of an ad campaign (product choosing, ad types, keywords), its management and success evaluation (calculation of ROI and modified ROI).

  3. Copper subtype of Alzheimer's disease (AD): meta-analyses, genetic studies and predictive value of non-ceruloplasmim copper in mild cognitive impairment conversion to full AD. (United States)

    Squitti, Rosanna


    Alzheimer's disease (AD) is the most common form of dementia. A myriad of complex factors contribute to AD, promoting the deposition in plaques of amyloid-beta (Aβ), which is the main constituent of this pathognomonic sign of AD at autopsy brain inspection. Aβ toxicity is related to oxidative stress, which results in synaptic loss in specific brain areas, eventually leading to cognitive decline. Metal, and especially copper, dyshomeostasis is a key factor in these processes. Recent studies have demonstrated that the serum fraction of copper that is not bound to ceruloplasmin (Non-Cp copper, also known as 'free' or labile copper) increases in a percentage of AD patients and mild cognitive impairment (MCI) subjects; this is considered a precursor of AD. Non-Cp copper is the exchangeable fraction of low molecular weight copper in serum. It is distinguished from the copper structurally bound to the ceruloplasmin protein, a master protein of iron metabolism. Non-Cp copper levels are higher than normal reference values (range 0-1.6μmol/L) in about 50% of amnestic MCI subjects and 60% of AD patients, typifying them in a subset of AD. Meta-analyses, genetic studies and a prognostic study evaluating the predictive value of Non-Cp copper in MCI conversion to full AD demonstrate the existence of this copper phenotype of AD. Copyright © 2014 Elsevier GmbH. All rights reserved.

  4. Sensor and ad-hoc networks theoretical and algorithmic aspects

    CERN Document Server

    Makki, S Kami; Pissinou, Niki; Makki, Shamila; Karimi, Masoumeh


    This book brings together leading researchers and developers in the field of wireless sensor networks to explain the special problems and challenges of the algorithmic aspects of sensor and ad-hoc networks. The book also fosters communication not only between the different sensor and ad-hoc communities, but also between those communities and the distributed systems and information systems communities. The topics addressed pertain to the sensors and mobile environment.

  5. Added values of photovoltaic power systems

    Energy Technology Data Exchange (ETDEWEB)



    The structure, ownership and operation of electricity systems around the world are changing in response to industry restructuring, the availability of new technologies and increasing environmental awareness. At the same time, many countries have yet to provide basic energy services for their populations, particularly in areas not served by the electricity grid. Large-scale, central power generation and distribution which characterized the electricity industry for much of the 20{sup th} century is being challenged by new technologies, which are cleaner, faster to deploy and better matched to local requirements. Higher values are being placed on ancillary services, such as power system reliability and voltage stability, so that a simple comparison of energy cost is no longer appropriate as a measure of competitiveness. Solar photovoltaic electricity is unique amongst the new energy sources for the wide range of energy and non-energy benefits which can be provided, while the use of photovoltaic power systems as an integral part of a building provides the greatest opportunity for exploiting non-energy benefits and for adding value to the photovoltaic power system. This report documents the potential added values or non-energy benefits photovoltaic power systems can provide, the current state of market development and the key barriers faced by renewable energy technologies generally and photovoltaic power systems in particular. Means by which non-energy benefits may be used to overcome barriers to the use of photovoltaic power systems are then discussed, with specific attention to the use of building integrated photovoltaics. (author)

  6. Thermodynamic Volume in AdS/CFT (United States)

    Kim, Kyung Kiu; Ahn, Byoungjoon


    In this note, we study on extended thermodynamics of AdS black holes by varying cosmological constant. We found and discussed pressure and volume of both bulk and boundary physics through AdS/CFT correspondence. In particular, we derive the relation between thermodynamic volume and a chemical potential for M2 brane dual to four dimensional AdS space. In addition, we show that thermodynamic volume of hyperbolic black hole is related to `entanglement pressure' coming from a generalized first law of entanglement entropy.

  7. Sensibility and Subjectivity: Levinas’ Traumatic Subject

    Directory of Open Access Journals (Sweden)

    Rashmika Pandya


    Full Text Available The importance of Levinas’ notions of sensibility and subjectivity are evident in the revision of phenomenological method by current phenomenologists such as Jean-Luc Marion and Michel Henry. The criticisms of key tenants of classical phenomenology, intentionality and reduction, are of a particular note. However, there are problems with Levinas’ characterization of subjectivity as essentially sensible. In “Totality and Infinity” and “Otherwise than Being”, Levinas criticizes and recasts a traditional notion of subjectivity, particularly the notion of the subject as the first and foremost rational subject. The subject in Levinas’ works is characterized more by its sensibility and affectedness than by its capacity to reason or affect its world. Levinas ties rationality to economy and suggests an alternative notion of reason that leads to his analysis of the ethical relation as the face-to-face encounter. The ‘origin’ of the social relation is located not in our capacity to know but rather in a sensibility that is diametrically opposed to the reason understood as economy. I argue that the opposition in Levinas’ thought between reason and sensibility is problematic and essentially leads to a self-conflicted subject. In fact, it would seem that violence characterizes the subject’s self-relation and, thus, is also inscribed at the base of the social relation. Rather than overcoming a problematic tendency to dualistic thought in philosophy Levinas merely reverses traditional hierarchies of reason/emotion, subject/object and self/other. 

  8. Using Academic Journals to Help Students Learn Subject Matter Content, Develop and Practice Critical Reasoning Skills, and Reflect on Personal Values in Food Science and Human Nutrition Classes (United States)

    Iwaoka, Wayne T.; Crosetti, Lea M.


    It has been reported that students learn best when they use a wide variety of techniques to understand the information of the discipline, be it visual, auditory, discussion with others, metacognition, hands-on activities, or writing about the subject. We report in this article the use of academic journals not only as an aid for students to learn…

  9. Initial results of a study into the estimation of the development of frequency lock-in for offshore structures subjected to ice loading

    NARCIS (Netherlands)

    Hendrikse, H.; Seidel, Marc; Metrikine, A.; Loset, Sveinung


    Ice-induced vibrations have to be considered in design of vertically sided offshore structures subjected to loading by sea ice, such as offshore wind turbines and oil- and gas platforms. The interaction between ice and structure may result in high global peak loads and the occurring structural

  10. A diffusion tensor MRI study of patients with MCI and AD with a 2-year clinical follow-up. (United States)

    Scola, Elisa; Bozzali, Marco; Agosta, Federica; Magnani, Giuseppe; Franceschi, Massimo; Sormani, Maria Pia; Cercignani, Mara; Pagani, Elisabetta; Falautano, Monica; Filippi, Massimo; Falini, Andrea


    The authors assessed whether brain changes detected by diffusion tensor (DT) MRI can improve the understanding of structural damage in Alzheimer's disease (AD) and are associated with different risks of conversion to AD in amnestic mild cognitive impairment (aMCI). Twenty-one aMCI patients, 21 AD patients and 20 healthy subjects underwent conventional and DT MRI at baseline. All subjects were clinically followed up over 2 years; at the end of follow-up, aMCI were grouped into converters to AD (aMCI-C) and non-converters (aMCI-NC). The mean diffusivity (MD) and fractional anisotropy (FA) were obtained from total grey matter (GM) and white matter (WM), and from several GM and WM regions of interest (ROIs). On T1-weighted images, normalised volumes of the whole brain (NBV), GM (NGMV) and WM were measured. A significant 'trend' of worsening with a trajectory 'normal/aMCI/AD' was found for NBV and NGMV, total GM and WM MD, total WM FA, as well as for diffusivity abnormalities in several GM and WM ROIs, mainly located in posterior brain regions. aMCI-C had GM and WM changes similar to those seen in AD, whereas aMCI-NC showed a DT MRI pattern similar to that of healthy subjects. DT MRI metrics that better distinguished aMCI-C from aMCI-NC were MD of total GM and WM, hippocampi, anterior insulae, frontal and parietal WM, occipital GM and WM, and FA of temporal WM. Volumetric variables were not able to distinguish the two aMCI subgroups (aMCI-C and aMCI-NC). Subtle brain diffusivity changes occur from the prodromal stages of AD, mainly in posterior brain regions, and spread over the course of the disease to involve the frontal lobe. In aMCI, the severity of microstructural damage within and beyond the medial temporal lobe is associated with an increased short-term risk to develop AD.

  11. ASPIRE: Added-value Sensing

    DEFF Research Database (Denmark)

    Anggorojati, Bayu; Cetin, Kamil; Mihovska, Albena D.


    FP7 ICT project ASPIRE is one of the coordinated European efforts to further the advancement of this technology, in the areas of enabling technology development for RFID. The focus of ASPIRE is on the design, development and adoption of an innovative, programmable, royalty-free, lightweight...... and privacy friendly RFID middleware. Advances in active RFID integration with WSNs allow for more RFID-based applications to be developed. In order to fill the gap between the active RFID system and the existing middleware, a HAL for active reader and ALE server extension to support sensing data from active...

  12. Studies on the preparation of value-added products for industrial minerals

    Energy Technology Data Exchange (ETDEWEB)



    This report consists of 2 subjects. 1) Studies on the preparation of value-added products for limestone: This study has investigated to raise to high grade by economical processes with low grade of domestic limestone. We investigated the status of application utilize and related industries with the domestic limestone, and then being consideration with condition selected the adequate sample from Andong, Jungsun and Kumsan area. Magnetic materials were involved in impurities of sample, so magnetic separation method was applied in elimination of the ferro- and para-magnetic materials, such as chlorite, muscovite, quartz, dolomite, magnetite, feldspar and so on. Investigation of flotation was undertaken to eliminate impurities from limestone crude ore and the tests were performed to get a optimum condition adding oleic acid as a promoter, sodium silicate and sodium carbonate as a conditioning agents and MIBC as a frother, while to float the sulfide minerals added amyl xanthate as a promoter, and sulfuric acid as a pH regulator. Selective crushing and classification methods were performed to eliminate impurities depends on the mineral properties and should be the selective crushing methods are very useful at the manufacturing factory of heavy calcium carbonate with the dry milling system. 2) A study on development of value added technology of pyrophyllite and dickite: Pyrophyllite and dickite have being utilized as refractories, ceramics, cement, fiber glass, paper, rubber, paints etc. However, there are not any domestic companies to produce fillers of pyrophyllite and dickite for plastic and rubber. Moreover, several kinds of fillers are imported every year with expensive price for plastic and rubber filler. This study has purpose to develop manufacturing technologies to produce fillers for plastic and rubber of pyrophyllite and dickite. The chemical and mineralogical properties of samples, the optimum grinding condition and device for producing plastic fillers and

  13. Protein domain organisation: adding order

    Directory of Open Access Journals (Sweden)

    Kummerfeld Sarah K


    Full Text Available Abstract Background Domains are the building blocks of proteins. During evolution, they have been duplicated, fused and recombined, to produce proteins with novel structures and functions. Structural and genome-scale studies have shown that pairs or groups of domains observed together in a protein are almost always found in only one N to C terminal order and are the result of a single recombination event that has been propagated by duplication of the multi-domain unit. Previous studies of domain organisation have used graph theory to represent the co-occurrence of domains within proteins. We build on this approach by adding directionality to the graphs and connecting nodes based on their relative order in the protein. Most of the time, the linear order of domains is conserved. However, using the directed graph representation we have identified non-linear features of domain organization that are over-represented in genomes. Recognising these patterns and unravelling how they have arisen may allow us to understand the functional relationships between domains and understand how the protein repertoire has evolved. Results We identify groups of domains that are not linearly conserved, but instead have been shuffled during evolution so that they occur in multiple different orders. We consider 192 genomes across all three kingdoms of life and use domain and protein annotation to understand their functional significance. To identify these features and assess their statistical significance, we represent the linear order of domains in proteins as a directed graph and apply graph theoretical methods. We describe two higher-order patterns of domain organisation: clusters and bi-directionally associated domain pairs and explore their functional importance and phylogenetic conservation. Conclusion Taking into account the order of domains, we have derived a novel picture of global protein organization. We found that all genomes have a higher than expected

  14. The added value of advisory services in SME mergers and acquisitions

    NARCIS (Netherlands)

    Lex van Teeffelen


    The objective of this study is to shed light on the added value of the services of five disciplines in M&A advisory in the SME domain: accountants, bankers, business brokers, fiscalists and lawyers. Theory is inconclusive in the added value of advisory services and research on the subject is hardly

  15. The Effect of Comparatively-Framed versus Similarity-Framed E-Cigarette and Snus Print Ads on Young Adults' Ad and Product Perceptions. (United States)

    Banerjee, Smita C; Greene, Kathryn; Li, Yuelin; Ostroff, Jamie S


    This study examined the effects of comparative-framing [C-F; ads highlighting differences between the advertised product and conventional cigarettes and/or smokeless tobacco products] versus similarity-framing (S-F; ads highlighting congruence with conventional cigarettes and/or smokeless tobacco products) in e-cigarette and snus ads on young adult smokers' and non-smokers' ad- and product-related perceptions. One thousand fifty one (1,051) young adults (18-24 years; 76% women; 50% smokers) from existing consumer panels were recruited in a within-subjects quasi-experiment. Each participant viewed 4 online advertisements, varied by tobacco product type (e-cigarette or snus) and ad framing (C-F or S-F). The dependent measures for this study were ad-related (ad perceptions, ad credibility) and product-related perceptions (absolute and comparative risk perceptions, product appeal, and product use intentions). Former and current smokers rated C-F ads as more persuasive than S-F ads, as evidenced by favorable ad perceptions and high product use intentions. Former and current smokers also rated e-cigarette ads with more favorable ad perceptions, low absolute and comparative risk perceptions, high product appeal, and high product use intentions as compared to snus ads. However, the effect sizes of the significant differences are less than.2, indicating small magnitude of difference between the study variables. Unless FDA regulates e-cig and snus advertising, there is a potential of decreasing risk perceptions and increasing use of e-cigs among young adults. Further research on implicit/explicit comparative claims in e-cigarettes and snus advertisements that encourage risk misperceptions is recommended.

  16. Gender-related dissociations of categorical fluency in normal subjects and in subjects with Alzheimer's disease. (United States)

    Marra, Camillo; Ferraccioli, Monica; Gainotti, Guido


    Semantic fluency tasks, with the categories of birds and furniture as stimuli, were administered to normal subjects and patients with Alzheimer's disease (AD). Normal subjects showed a gender-related double dissociation consistent with the literature data because men were more fluent with the birds category and women with the furniture category. Also, patients with AD showed a Gender x Category interaction, but the double dissociation between birds and furniture was not present because of a prevalent impairment of the living category birds that was irrespective of gender. This pattern of impairment in patients with AD was independent from the disease stage. The authors conclude that (a) gender-related categorical effects cannot be considered as inborn, sex-related cognitive differences but as familiarity effects and (b) both lesion-related and familiarity-related factors must be taken into account to explain category-specific effects of patients with brain damage and patients with AD.

  17. Discrepancy between subjective autobiographical reliving and objective recall: The past as seen by Alzheimer's disease patients. (United States)

    El Haj, Mohamad; Antoine, Pascal


    This paper investigated whether Alzheimer's disease (AD) patients may demonstrate a discrepancy between subjective autobiographical reliving and objective recall. To this end, 31 AD patients and 35 controls were asked to retrieve three autobiographical memories. For each memory, participants were asked to rate its subjective characteristics (e.g., reliving, travel in time, visual imagery…). Besides this subjective assessment, we analyzed recall objectively with regard to specificity. Results showed poorer subjective autobiographical reliving and objective recall in AD patients than in controls. A discrepancy (i.e., higher level of subjective reliving than of objective recall) was observed in AD but not in control participants. Despite a compromise in their objective recall, AD patients seemed to attribute a high value to their subjective autobiographical experience. This discrepancy can be attributed to a potential genuine consciousness experience in which mild AD patients can, to some extent, experience some subjective features of the past. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Regulatory Approaches for Adding Capacity to Existing Hydropower Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Levine, Aaron L. [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Curtis, Taylor L. [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Kazerooni, Borna [National Renewable Energy Laboratory (NREL), Golden, CO (United States)


    In 2015, hydroelectric generation accounted for more than 6 percent of total net electricity generation in the United States and 46 percent of electricity generation from all renewables. The United States has considerable hydroelectric potential beyond what is already being developed. Nearly 7 GW of this potential is found by adding capacity to existing hydropower facilities. To optimize the value of hydroelectric generation, the U.S. Department of Energy's Hydropower Vision Study highlights the importance of adding capacity to existing facilities. This report provides strategic approaches and considerations for Federal Energy Regulatory Commission licensed and exempt hydropower facilities seeking to increase generation capacity, which may include increases from efficiency upgrades. The regulatory approaches reviewed for this report include capacity and non-capacity amendments, adding capacity during relicensing, and adding capacity when converting a license to a 10-MW exemption.

  19. III Adli Bilimler Kongresi - Posterler

    Directory of Open Access Journals (Sweden)

    Adli Tıp Uzmanları Derneği ATUD


    Full Text Available POSTER ÖZETLERİ ADLİ ÇOCUK OTOPSİLERİ Y.Mustafa KARAGÖZ*, Mehmet ATILGAN*, Sema (Demirçin KARAGÖZ**, Refik AKMAN*. ÖZET Çocukluk döneminde meydana gelen ölümlerin aydınlatılması, sağlık hizmetlerinin yönlendirilmesinde olduğu kadar, yasal açıdan da farklı yaklaşımları gerektirdiğinden büyük önem taşımaktadır. Bu çalışmada çocuk otopsilerine ait verilerden yararlanılarak özellikle ölüm orijinleri ve yöresel farklılıklar açısından çocuk ölümlerinin irdelenmesi amaçlanmıştır. 1987-1996 yılları arasındaki 10 yıllık süre içinde Adli Tıp Kurumu Antalya Şube Müdürlüğü’nde otopsisi yapılan 940 olgudan 18 yaş ve altındaki 172 olgu çalışma kapsamına alınarak yaş grupları, cinsiyet, ölüm nedenleri ve orijinler açısından değerlendirilmiştir. Olguların % 58.1’i erkek, % 4l.9’u kadındır. Ölüm orijinleri arasında ilk sırada kazalar (%34.3 bulunmakta, ardından intiharlar (% 19.2 gelmektedir. Kazalarda % 40.6, intiharlarda % 72.8 olmak üzere her iki gruptaki ölüm nedenleri arasında da pestisit intoksikasyonları ilk sıradadır. Doğal ölümler % 16.9 oranında olup solunum sistemi hastalıkları ön plandadır. 0-4, 5-9, ve 10-14 yaş gruplarında kazalar, 15-18 yaş grubunda ise % 36.7 lik bir oranla intihar orijinli ölümler ilk sırada yer almıştır. GÖĞÜS VE BATINA NAFİZ KESİCİ DELİCİ ALET YARALANMALARINA BAĞLI ÖLÜMLERİN RETROSPEKTİF OLARAK DEĞERLENDİRİLMESİ Süleyman GÖREN, Yaşar TIRAŞÇI. ÖZET Kesici delici aletler günümüzde çok yaygın olarak, çeşitli tip ve nitelikte evlerde ve birçok iş yerinde meslek ve sanat icrası için kullanılmaktadır. Bu aletlerin tip ve nitelikleri salt saldırı ve savunma silahı olarak kullanılan aletleri aratmayacak özelliktedir. Bu nedenle bölgedeki kesici delici alet yaralanması ile ölümler ve demografik özellikleri araştırılmaya değer görülmüştür. 1989 - 1996 y


    Directory of Open Access Journals (Sweden)



    Full Text Available The financial theory developed different categories of indicators - traditional and modern - in order to evaluate the firm’s value creation. The shareholders are directly interested by the value added in the company. The value creation is a complex process that implies correct decisions, common responsibility (managers and shareholders and actions towards an efficient and profitable activity. The traditional indicators of performance are not teoritically correlated with the the value creation and in these circumstances, should be used appropriate financial indicators in order to reflect the value of the company. Therefore, the modern indicators used in the value based management framework offer a greater flexibility and efficiency and represent a good alternative for companies. Such performance indicators used to measure the financial results correlated with shareholder wealth are the Economic Value Added (EVA, as a measure of internal performance and the Market Value Added (MVA as a measure of external performance of the company. Starting from the main deficiencies of the accounting indicators, the objective of this this study is to present the relationship between EVA and MVA and their implications on firms’valuation. Thus, the presentation and analysis of these indicators – EVA and MVA - will underline the main features, their correlations, and influence factors but also the main advantage and disadvantage of each indicator, which will enable the managers to make the correct choice and subsequently the best decision regarding the performance measures.



    Ranganadh Narayanam


    In this research as a first step we have concentrated on collecting non-intra cortical EEG data of Brainstem Speech Evoked Potentials from human subjects in an Audiology Lab in University of Ottawa. The problems we have considered are the most advanced and most essential problems of interest in Auditory Neural Signal Processing area in the world: The first problem is the Voice Activity Detection (VAD) in Speech Auditory Brainstem Responses (ABR); The second problem is to identify the best De-...

  2. Creating Flash advertising from concept to tracking-microsites, video ads and more

    CERN Document Server

    Fincanon, Jason


    Create awe-inspiring, mind-blowing Flash ads and microsites that engage consumers and demonstrate their worth to clients. The Hands-On Guide to Creating Flash Advertising delivers the nuts and bolts of the development process from initial design conception to ad completion. You'll learn the best practices for:* Mastering the myriad of ad specs, deadlines, quality and version control issues* Creating ads that balance campaign goals with design constraints* Preparing and building ads with team and QC standards* Using forms and data in ads without file bloat* File optimization techniques for swf

  3. How French subjects describe well-being from food and eating habits? Development, item reduction and scoring definition of the Well-Being related to Food Questionnaire (Well-BFQ©). (United States)

    Guillemin, I; Marrel, A; Arnould, B; Capuron, L; Dupuy, A; Ginon, E; Layé, S; Lecerf, J-M; Prost, M; Rogeaux, M; Urdapilleta, I; Allaert, F-A


    Providing well-being and maintaining good health are main objectives subjects seek from diet. This manuscript describes the development and preliminary validation of an instrument assessing well-being associated with food and eating habits in a general healthy population. Qualitative data from 12 groups of discussion (102 subjects) conducted with healthy subjects were used to develop the core of the Well-being related to Food Questionnaire (Well-BFQ). Twelve other groups of discussion with subjects with joint (n = 34), digestive (n = 32) or repetitive infection complaints (n = 30) were performed to develop items specific to these complaints. Five main themes emerged from the discussions and formed the modular backbone of the questionnaire: "Grocery shopping", "Cooking", "Dining places", "Commensality", "Eating and drinking". Each module has a common structure: items about subject's food behavior and items about immediate and short-term benefits. An additional theme - "Eating habits and health" - assesses subjects' beliefs about expected benefits of food and eating habits on health, disease prevention and protection, and quality of ageing. A preliminary validation was conducted with 444 subjects with balanced diet; non-balanced diet; and standard diet. The structure of the questionnaire was further determined using principal component analyses exploratory factor analyses, with confirmation of the sub-sections food behaviors, immediate benefits (pleasure, security, relaxation), direct short-term benefits (digestion and satiety, energy and psychology), and deferred long-term benefits (eating habits and health). Thirty-three subscales and 14 single items were further defined. Confirmatory analyses confirmed the structure, with overall moderate to excellent convergent and divergent validity and internal consistency reliability. The Well-BFQ is a unique, modular tool that comprehensively assesses the full picture of well-being related to food and eating habits in

  4. Joule-Thomson Expansion of Charged AdS Black Holes

    CERN Document Server

    Ökcü, Özgür


    In this paper, we study Joule-Thomson effects for charged AdS black holes. We obtain inversion temperatures and curves. We investigate similarities and differences between van der Waals fluids and charged AdS black holes for the expansion. We obtain isenthalpic curves for both systems in $T-P$ plane and determine the cooling-heating regions.

  5. Joule-Thomson expansion of the charged AdS black holes

    Energy Technology Data Exchange (ETDEWEB)

    Oekcue, Oezguer; Aydiner, Ekrem [Istanbul University, Department of Physics, Faculty of Science, Vezneciler, Istanbul (Turkey)


    In this paper, we study Joule-Thomson effects for charged AdS black holes. We obtain inversion temperatures and curves. We investigate similarities and differences between van der Waals fluids and charged AdS black holes for the expansion. We obtain isenthalpic curves for both systems in the T-P plane and determine the cooling-heating regions. (orig.)

  6. Static Einstein-Maxwell Black Holes with No Spatial Isometries in AdS Space. (United States)

    Herdeiro, Carlos A R; Radu, Eugen


    We explicitly construct static black hole solutions to the fully nonlinear, D=4, Einstein-Maxwell-anti-de Sitter (AdS) equations that have no continuous spatial symmetries. These black holes have a smooth, topologically spherical horizon (section), but without isometries, and approach, asymptotically, global AdS spacetime. They are interpreted as bound states of a horizon with the Einstein-Maxwell-AdS solitons recently discovered, for appropriate boundary data. In sharp contrast to the uniqueness results for a Minkowski electrovacuum, the existence of these black holes shows that single, equilibrium, black hole solutions in an AdS electrovacuum admit an arbitrary multipole structure.

  7. Effects of ad placement and type on consumer responses to podcast ads. (United States)

    Ritter, Eric A; Cho, Chang-Hoan


    The purpose of this study was to understand the effects of podcast ad placement and podcast ad type on consumers' perceived intrusiveness, perceived irritation, attitude toward the ad, and ad avoidance. Our 2 x 2 (traditional ad vs. sponsorship by beginning vs. middle) experimental study found that sponsorships generated better consumer responses than did traditional ads and that podcast ads placed at the beginning of audio podcasts yielded better consumer responses than those placed in the middle. Implications for marketers and advertisers are discussed.

  8. Cognitive Event-Related Potential, an Early Diagnosis Biomarker in Frail Elderly Subjects: The ERP-MAPT-PLUS Ancillary Study. (United States)

    Bennys, Karim; Gabelle, Audrey; Berr, Claudine; De Verbizier, Delphine; Andrieu, Sandrine; Vellas, Bruno; Touchon, Jacques


    By analyzing brain synaptic function, cognitive event-related potentials (ERPs) could provide powerful and innovative tools for early Alzheimer's disease (AD) diagnosis. We investigated the relevance of the ERP-P300 component as a potential diagnosis marker in elderly subjects at risk of developing AD. ERP-P300 was analyzed on 85 subjects recruited from the Multidomain Alzheimer Preventive Trial (MAPT). PET-AV45 brain imaging was available from 36 subjects. Two ERP-P300 subgroups were identified according to their PET-AV45 status: PET-Aβ positive (n = 15) and PET-Aβ negative (n = 21). In the amyloid positive group, we observed a highly significant increase in P3b latency in parietal brain regions (p = 0.0052). P3b in parietal regions correctly categorized 69.4% elderly subjects from the P300-PET Aβ positive group. Combined analysis of parietal P3b latencies and category fluency correctly classified 75% subjects from the P300-PET Aβ positive group. The P300 ERP presents good predictive measure of brain amyloid load and has the potential to be used as a screening instrument for preclinical AD. The incorporation of P3b latency may be used as an adjunctive tool with neuropsychological assessment (i.e., verbal category fluency) as a specific and sensitive method for preclinical assessment of AD.

  9. Feasibility study on a complete system of production, transportation and utilization of about 7 MTa of CWS from Shenmu area and Yellow Sea (China). Results of a Beijing symposium on the subject in Beijing (April 1994) and creation of a World Laboratory research centre ad hoc in Beijing

    Energy Technology Data Exchange (ETDEWEB)

    Novelli, G.; Wang Zuna [ICSC World Lab., Lausanne (Switzerland). Project NET-1


    The authors had occasion at a coal-water slurry conference in Clearwater to present a preliminary part of a feasibility study, in cooperation with an Italian and a Chinese team, for a complete integrated project of mining, slurryfication, transportation via pipeline, and utilization of 7 millions tons/year of coal. This study started in 1987 and was presented to the Chinese authority on April 1994 in a specific symposium in Beijing with a participation of 60 scientists from Italy and P.R. China. During this long period of cooperation and exchange between the parties, it was possible to organize a complete and advanced Centre of Research in Beijing supplied with modern equipment that is now in full operation and is producing work of very good quality. The goal of this paper is to summarize the above mentioned experience and describe the new Centre, the present status and the future developments. The study and the equipment of the Centre was sponsored by the World Laboratory an International Institution established in Lausanne under the presidency of Prof. A. Zichichi. This organization supported particularly by the Italian government is responsible for several programs of cooperation between N-S-E-W countries in all the critical areas of planetary importance (health, energy, agriculture, food, environment).

  10. RFID added value sensing capabilities

    DEFF Research Database (Denmark)

    Anggorjati, B.; Çetin, K.; Mihovska, A.


    Radio frequency identification (RFID) is a key technology for Europe. Since the initial emergence of the technology, there has been a noticeable shift away from RFID pilot projects of the early days, towards a broad deployment of RFID in order to increase the efficiency and innovation of processes....... Even though Europe is a leading player in the world of RFID technology, several challenges need to be addressed in order for RFID to reach its full potential. The funded under FP7 ICT project ASPIRE is one of the coordinated European efforts to further the advancement of this technology, in the areas...... of enabling technology development for RFID. In particular, the focus of ASPIRE is on design, development and adoption of an innovative, programmable, royalty-free, lightweight and privacy friendly RFID middleware....

  11. Numerical cognition: Adding it up. (United States)

    LeFevre, Jo-Anne


    In this article, I provide a historical overview of the field of numerical cognition. I first situate the evolution and development of this field in the more general context of the cognitive revolution, which started in the mid-1950s. I then discuss the genesis of numerical cognition from 6 areas: psychophysics, information processing, neuropsychology, mathematics education, psychometrics, and cognitive development. This history is personal: I discuss some of my own work over the last 30 years and describe how each of the authors of the articles in this collection originally connected with the field. One important goal of the article is to highlight the major findings, both for experts and for those who are less familiar with research on numerical processing. In sum, I sketch a context within which to appreciate the neural, computational, and behavioural work that the other 4 authors summarise in their articles in this special section. (c) 2016 APA, all rights reserved).

  12. Aspects of AdS, CFT. Black solutions in gauged supergravity and holographic conductivities

    Energy Technology Data Exchange (ETDEWEB)

    Barisch-Dick, Susanne


    We have met some interesting results within the wide subject of the AdS/CFT correspondence. We have seen how to apply AdS/CFT techniques to calculate the frequency dependent conductivity tensor for field theories dual to a black hole in Einstein-Yang-Mills theory with SU(2) gauge group. Further, we have constructed several new black solutions in N=2 U(1) gauged supergravity in four and five dimensions. The larger part of these solutions behave asymptotically like AdS which makes them interesting within the AdS/CFT context. In addition we found extremal black branes with zero entropy density - the Nernst branes. Nonetheless we are left with some yet unsolved problems. It is very interesting to see what causes the negative entropy production rate we found in chapter 4 for the normal state of the field theory. The next task is to see whether we can find an instability on the gravity side looking at the full Einstein-Yang-Mills equations. Also our work on supergravity solutions in four and five dimension exhibits some ''loose ends''. Since all our four-dimensional Nernst solutions were axion-free it would be nice to find one with axions excited. Moreover, it would be interesting to see whether the singular solutions with flowing γ could be cured by taking into account higher derivative corrections or whether there exist non-singular solutions with non-constant γ. In five dimensions we met problems when adding electric charge. At present we could not find a dyonic solution and we had the impression that having electric charges and having magnetic fields seemed to be somehow complementary to each other. We saw these difficulties even at the beginning when we performed the first-order rewriting since the first-order rewriting in chapter 6 leads to flow equations for the scalars X{sup A} which only contain magnetic fields and fluxes but no electric charges. The latter only influence the equations of motion for the X{sup A} in an indirect way. However

  13. Unpleasant subjective emotional experiencing of pain

    Directory of Open Access Journals (Sweden)

    Nandini Vallath


    Full Text Available The field of pain medicine that once began as a supportive and compassionate care, adding value to the management of acute and chronic ailments, has now transformed into a vital and essential specialty with structured training programs and service units with professionals dedicating their careers to it. The expansion of understanding of the direct relationship of pain relief to the quality of life, uncovering of neuronal pathways, and technological advances in imaging as well as in interventional techniques have all contributed to this phenomenal growth. However, there is a growing concern whether the training programs and the specialized practitioners are gradually limiting their skilled inputs primarily within the sensory realm of the pain experience with sophisticated interventional techniques and relegating its subjective and emotional dimensions to perfunctory realms within the schema of service provision. While the specialty is still young, if we can understand the inherent aspect of these dimensions within the pain experience and acknowledge the gaps in service provision, it may be possible to champion development of truly comprehensive pain relief programs that responds effectively and ethically to a patient′s felt needs. This article attempts to position the subjectivity of pain experience in context and surface the need to design complete systems of pain relief services inclusive of this dimension. It presents authors′ review of literature on perspectives of ′unpleasant subjective emotional experiencing of the pain" to elucidate possible clinical implications based on the evidences presented on neuro-biology and neuro-psychology of the pain experience; the aim being to inspire systems of care where this dimension is sufficiently evaluated and managed.

  14. International Energy: Subject Thesaurus. Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    Rutkowski, R.W. [ed.


    The Energy Technology Data Exchange (ETDE) is a consortium of member countries around the globe that share their energy research and technology information through ETDE`s database. The Exchange was established in 1987 under the auspices of the International Energy Agency (IEA) and serves all ETDE member countries. The Exchange also collaborates with other entities as appropriate.The International Energy:Subject Thesaurus [ETDE/PUB--2(Rev.2)] contains the standard vocabulary of indexing terms (descriptors) developed and structured to build and maintain energy information databases. Involved in this cooperative task are (1) the technical staff of the U.S. DOE Office of Scientific and technical Information (OSTI) in cooperation with the member countries of the International Energy Agency`s Energy Technology Data Exchange (ETDE) and (2) the International Atomic Energy Agency`s International Nuclear Information System (INIS) staff representing the more than 100 countries and organizations t hat record and index information for the international nuclear information community. Because all ETDE member countries are also members of INIS, the contents of INIS`s database are included in ETDE`s database. Indexing terminology is therefore cooperatively standardized for use in both information systems. This structured vocabulary reflects the scope of international energy research and technology programs. The terminology of this thesaurus aids in subject searching on commercial systems, such as the online products offered by Knight-Ridder Information Services and STN International and the CD-ROM products offered by Silver Platter and Knight-Ridder. This thesaurus can also be used with the in-house systems provided by some ETDE member countries. Descriptors are added to the thesaurus as needed (i.e., when a document contains a concept for which there is no adequate term or terms in the thesaurus). More than 28,000 entries appear in this document, which replaced International

  15. Optimizing nasal potential difference analysis for CFTR modulator development: assessment of ivacaftor in CF subjects with the G551D-CFTR mutation.

    Directory of Open Access Journals (Sweden)

    Steven M Rowe

    Full Text Available Nasal potential difference (NPD is used as a biomarker of the cystic fibrosis transmembrane conductance regulator (CFTR and epithelial sodium channel (ENaC activity. We evaluated methods to detect changes in chloride and sodium transport by NPD based on a secondary analysis of a Phase II CFTR-modulator study. Thirty-nine subjects with CF who also had the G551D-CFTR mutation were randomized to receive ivacaftor (Kalydeco™; also known as VX-770 in four doses or placebo twice daily for at least 14 days. All data were analyzed by a single investigator who was blinded to treatment assignment. We compared three analysis methods to determine the best approach to quantify changes in chloride and sodium transport: (1 the average of both nostrils; (2 the most-polarized nostril at each visit; and (3 the most-polarized nostril at screening carried forward. Parameters of ion transport included the PD change with zero chloride plus isoproterenol (CFTR activity, the basal PD, Ringer's PD, and change in PD with amiloride (measurements of ENaC activity, and the delta NPD (measuring CFTR and ENaC activity. The average and most-polarized nostril at each visit were most sensitive to changes in chloride and sodium transport, whereas the most-polarized nostril at screening carried forward was less discriminatory. Based on our findings, NPD studies should assess both nostrils rather than a single nostril. We also found that changes in CFTR activity were more readily detected than changes in ENaC activity, and that rigorous standardization was associated with relatively good within-subject reproducibility in placebo-treated subjects (± 2.8 mV. Therefore, we have confirmed an assay of reasonable reproducibility for detecting chloride-transport improvements in response to CFTR modulation.

  16. Development and validation of a structured questionnaire for the diagnosis of oral allergy syndrome in subjects with seasonal allergic rhinitis during the UK birch pollen season. (United States)

    Skypala, I J; Calderon, M A; Leeds, A R; Emery, P; Till, S J; Durham, S R


    Birch pollen-associated oral allergy syndrome, also known as pollen-food syndrome (PFS), is the most common food allergy in adults in the United Kingdom. Because of its characteristic rapid onset of oro-pharyngeal symptoms associated with specific plant foods, it was hypothesized that a history-based questionnaire could accurately diagnose PFS in subjects with rhino-conjunctivitis symptoms in the UK springtime. In this study of diagnostic accuracy, we aimed to validate a simple PFS diagnostic questionnaire and algorithm against a reference diagnostic test method (RTM) comprising diagnosis by expert evaluation of clinical history, skin prick tests and oral food challenge, in subjects reporting allergic rhinitis (AR) in the UK birch pollen season from March to May. Participants were UK adults reporting symptoms of spring time-AR (hayfever). They self-completed a diagnostic questionnaire in addition to undergoing an RTM comprising clinical history, skin prick testing to foods and pollens and oral food challenge. Subjects who reported anaphylaxis were excluded on the basis that they required specialist referral. One hundred and twenty three subjects took part in the study. Data from 110 participants were analysed; of the 13 exclusions, four provided insufficient data and nine reported anaphylaxis such that they warranted specialist assessment. Fifty-two participants (47%) were diagnosed with PFS by the RTM in comparison with 51 (46%) by a diagnostic questionnaire and algorithm (P=1.000, McNemar's test). The diagnostic questionnaire and algorithm had a sensitivity of 0.90 (0.78-0.96), a specificity of 0.93 (0.82-0.97), a positive predictive value of 0.92 (0.80-0.97) and a negative predictive value of 0.91 (0.80-0.96) when measured against the RTM. The diagnostic questionnaire and algorithm is a practical and robust tool, which enables rapid identification, and therefore management, of individuals with PFS who experience rhino-conjunctivitis symptoms in the UK birch

  17. Added Sugars and Cardiovascular Disease Risk in Children (United States)

    Vos, Miriam B.; Kaar, Jill L.; Welsh, Jean A.; Van Horn, Linda V.; Feig, Daniel I.; Anderson, Cheryl A.M.; Patel, Mahesh J.; Munos, Jessica Cruz; Krebs, Nancy F.; Xanthakos, Stavra A.; Johnson, Rachel K.


    BACKGROUND Poor lifestyle behaviors are leading causes of preventable diseases globally. Added sugars contribute to a diet that is energy dense but nutrient poor and increase risk of developing obesity, cardiovascular disease, hypertension, obesity-related cancers, and dental caries. METHODS AND RESULTS For this American Heart Association scientific statement, the writing group reviewed and graded the current scientific evidence for studies examining the cardiovascular health effects of added sugars on children. The available literature was subdivided into 5 broad subareas: effects on blood pressure, lipids, insulin resistance and diabetes mellitus, nonalcoholic fatty liver disease, and obesity. CONCLUSIONS Associations between added sugars and increased cardiovascular disease risk factors among US children are present at levels far below current consumption levels. Strong evidence supports the association of added sugars with increased cardiovascular disease risk in children through increased energy intake, increased adiposity, and dyslipidemia. The committee found that it is reasonable to recommend that children consume ≤25 g (100 cal or ≈6 teaspoons) of added sugars per day and to avoid added sugars for children sugars most likely can be safely consumed in low amounts as part of a healthy diet, few children achieve such levels, making this an important public health target. PMID:27550974


    Directory of Open Access Journals (Sweden)

    Ristina Siti Sundari


    Full Text Available Fish is not only perishable product but also has segmented market. Consumption market such wants the fresh fish and certainty size. The problem is when the size of fish is too big for consumption, so that product is not wanted by consumer anymore. This research aimed at knowing the added value of shredded Lele and Patin catfish agribusiness and increasing prosperity of humanitarian society throughout processing the shredded catfishes. The data of this research was analyzed by Added Value Analysis of Hayami. The result showed that the shredded product of Lele catfish gave the added value IDR 14.295,00 per kilograms with the added value ratio was 25,53 percent and Conversion value was 0,35. Whereas, the shredded product of Patin catfish gave the added value IDR 18.295,00 per kilogram with the added value ratio was 29,04 percent and Conversion value was 0,35. The agribusiness toward processing and marketing of shredded Lele and Patin catfish was innovative agribusiness that could develop business opportunity so that it could move on the economical wheel and increasing humanitarian society prosperity actively. The market demand was still very wide either in town or out of town. The partnership among various not only government but also non government associations would be a good matter toward this agribusiness is running well.

  19. Is Piaget's epistemic subject dead? (United States)

    Lawson, Anton E.

    Niaz (1990) presents arguments in favor of the retention of Piaget's epistemic subject as a theoretical construct to guide research and practice in science education and psychology. The intent of this article is to point out the weaknesses of those arguments and to suggest that the weight of evidence argues against the existence of the logical thinker postulated by Piaget. Therefore, contrary to Niaz's conclusion that the acceptance of Piaget's epistemic subject will facilitate the development of cognitive theories with greater explanatory power, the conclusion is reached that Piaget's epistemic subject is dead and that continued acceptance of this aspect of Piagetian theory would be counterproductive.

  20. Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT

    Directory of Open Access Journals (Sweden)


    Full Text Available Abstract Background The prognosis for young people diagnosed with diabetes during childhood remains poor and this is mainly related to the long-term risk of developing vascular complications. Microalbuminuria identifies subjects at risk for diabetic nephropathy (DN and cardiovascular disease (CVD. It is often detected in adolescence but is rarely treated before the age of 18 years, as at the end of puberty albumin excretion may decline and in some subjects will return into the normal range. However, evidence indicates that subjects with both transient and persistent microalbuminuria have experienced renal damage during puberty and thus reno-protection to prevent long-term complications is warranted. In adults with diabetes and microalbuminuria, the use of angiotensin converting enzyme inhibitors (ACEI and Statins is increasing, and in order to determine whether these agents are of value in the adolescent population a large randomized controlled clinical trial is needed. Methods/Design The Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT is a multi-center, randomized, double-blind, placebo-controlled trial of ACEI and Statin therapy in adolescents with type 1 diabetes. 500 high-risk adolescents, defined on the basis of their albumin excretion, are randomized to receive either ACEI (Quinapril or Statins (Atorvastatin or combination therapy or placebo for 3-4 years. There will also be a parallel open observational study, based on the follow-up of 400 low-risk non-randomized adolescents. The major endpoint of the study is the change in albumin excretion; secondary endpoints include markers of CVD, renal function, retinopathy, quality of life combined with assessment of compliance and potential health economic benefits. Discussion AdDIT will provide important data on the potential renal and cardiovascular protective effects of ACEI and Statins in high-risk adolescents. Long-term follow-up of the randomized subjects will provide



    Martha María Casas Rodríguez; Gerardo Quintero Pupo


    The work presented herein is a synthesis of an important pedagogical investigation for the aesthetic education of the art student in the elementary level. It was developed and validated in practice at Luis Casas Romero primary school. The objective is to reveal the relationship between the historical contents and aesthetics through a pedagogical model for the development of the aesthetic expression in the learning of Cuban History. It offers a pedagogical alternative for the aesthetic develop...

  2. The control processes and subjective well-being of Chinese teachers: Evidence of convergence with and divergence from the key propositions of the motivational theory of life-span development

    Directory of Open Access Journals (Sweden)

    Wan-Chi eWong


    Full Text Available An analytical review of the motivational theory of life-span development reveals that this theory has undergone a series of elegant theoretical integrations. Its claim to universality nonetheless brings forth unresolved controversies. With the purpose of scrutinizing the key propositions of this theory, an empirical study was designed to examine the control processes and subjective well-being of Chinese teachers (N = 637. The OPS-Scales (Optimization in Primary and Secondary Control Scales for the Domain of Teaching were constructed to assess patterns of control processes. Three facets of subjective well-being were investigated with the Positive and Negative Affect Schedule, the Life Satisfaction Scale, and the Subjective Vitality Scale. The results revealed certain aspects of alignment with and certain divergences from the key propositions of the motivational theory of life-span development. Neither primacy of primary control nor primacy of secondary control was clearly supported. Notably, using different criteria for subjective well-being yielded different subtypes of primary and secondary control as predictors. The hypothesized life-span trajectories of primary and secondary control received limited support. To advance the theory in this area, we recommend incorporating Lakatos’ ideas about sophisticated falsification by specifying the hard core of the motivational theory of life-span development and articulating new auxiliary hypotheses.

  3. Adding Four- Dimensional Data Assimilation (aka grid ... (United States)

    Adding four-dimensional data assimilation (a.k.a. grid nudging) to MPAS.The U.S. Environmental Protection Agency is investigating the use of MPAS as the meteorological driver for its next-generation air quality model. To function as such, MPAS needs to operate in a diagnostic mode in much the same manner as the current meteorological driver, the Weather Research and Forecasting (WRF) model. The WRF operates in diagnostic mode using Four-Dimensional Data Assimilation, also known as "grid nudging". MPAS version 4.0 has been modified with the addition of an FDDA routine to the standard physics drivers to nudge the state variables for wind, temperature and water vapor towards MPAS initialization fields defined at 6-hour intervals from GFS-derived data. The results to be shown demonstrate the ability to constrain MPAS simulations to known historical conditions and thus provide the U.S. EPA with a practical meteorological driver for global-scale air quality simulations. The National Exposure Research Laboratory (NERL) Computational Exposure Division (CED) develops and evaluates data, decision-support tools, and models to be applied to media-specific or receptor-specific problem areas. CED uses modeling-based approaches to characterize exposures, evaluate fate and transport, and support environmental diagnostics/forensics with input from multiple data sources. It also develops media- and receptor-specific models, process models, and decision support tools for use bo

  4. Scrutiny Heightens for "Value Added" Research Methods (United States)

    Viadero, Debra


    As value-added research designs gain in popularity and undergo increasing scrutiny, experts are beginning to wave cautionary flags about how best to make use of them in education. Value-added techniques for measuring student achievement appeal to administrators and policymakers at all levels of education because they quantify the gains that…

  5. Queueing Models for Mobile Ad Hoc Networks

    NARCIS (Netherlands)

    de Haan, Roland


    This thesis presents models for the performance analysis of a recent communication paradigm: \\emph{mobile ad hoc networking}. The objective of mobile ad hoc networking is to provide wireless connectivity between stations in a highly dynamic environment. These dynamics are driven by the mobility of

  6. Validity of Maxwell equal area law for black holes conformally coupled to scalar fields in $$\\text {AdS}_5$$ AdS 5 spacetime

    National Research Council Canada - National Science Library

    Miao, Yan-Gang; Xu, Zhen-Ming


    We investigate the $$P{-}V$$ P - V criticality and the Maxwell equal area law for a five-dimensional spherically symmetric AdS black hole with a scalar hair in the absence of and in the presence of a Maxwell field, respectively...

  7. Effects of added fluids on the perception of solid food. (United States)

    Pereira, Luciano Jose; de Wijk, René A; Gavião, Maria Beatriz D; van der Bilt, Andries


    The production of sufficient saliva is indispensable for good chewing. Recent research has demonstrated that salivary flow rate has little influence on the swallowing threshold. We examined the hypothesis that adding fluid to a food will influence the chewing process. Twenty healthy subjects chewed on melba toast, breakfast cake, carrot, peanut and Gouda cheese. In addition they chewed on these foods after we added different volumes of tap water or a solution of alpha-amylase. We measured jaw muscle activity and the number of cycles until swallowing. Furthermore, we obtained visual analogue scale (VAS) scores for texture and sound attributes for all foods and fluid conditions. The additional fluids significantly lowered muscle activity and swallowing threshold for melba, cake and peanut. The effect of alpha-amylase in the solutions was rather limited. Doubling the volume of tap water had a larger effect. Several texture and sound attributes of melba, cake and peanut were also significantly affected by the additional fluids. For melba, cake, and peanut we observed significant correlations between the physiology parameters and several attributes for the various fluid conditions. This indicates that the added fluid affects both the physiology (muscle activity and number of cycles) and the sensory perception of a number of texture and sound attributes. Adding fluid facilitates the chewing of dry foods (melba, cake), but does not influence the chewing of fatty (cheese) and wet products (carrot).

  8. Promoting Self-Directed Learning in Developing or Poorly Defined Subject Areas: A Problem-Based Course in Molecular Biology, Genetics, and Cancer. (United States)

    Edmondson, Katherine M.

    A new problem-based course in molecular biology, genetics, and cancer for first-year veterinary students was developed at the College of Veterinary Medicine at Cornell University (New York). The course was developed out of a desire to foster student-centered and lifelong learning and to integrate basic and clinical science knowledge despite a lack…

  9. Is Non-Subject Based Research Training a "Waste of Time," Good Only for the Development of Professional Skills? An Academic Literacies Perspective (United States)

    Bastalich, Wendy; Behrend, Monica; Bloomfield, Robert


    In recent years, contentiously for some, universities have developed generalist skills lists and associated curricula in response to government demand for more "employment-ready" graduates. Such training usually includes writing and communication. In Australia and the UK, guidelines designed to support the development of skills…

  10. Longitudinal study on oral health in subjects with Alzheimer's disease. (United States)

    Ship, J A; Puckett, S A


    To examine longitudinal oral health changes in unmedicated, generally healthy subjects with Alzheimer's disease (AD) and compare them to age- and gender-matched healthy, unmedicated control subjects. Oral health parameters were evaluated over 2 to 3 years and the results compared between subjects with AD and controls. Clinical Center of the National Institutes of Health, Bethesda, Maryland. Twenty-one community-dwelling subjects with a clinical diagnosis of AD and 21 age- and gender-matched control subjects. Neither population was being treated for any other systemic condition nor taking any prescription medications. Unstimulated and stimulated major salivary gland flow rates were measured, and gingival, periodontal, dental, and oral mucosal tissues assessed. In general, subjects with AD demonstrated decreased salivary flow rates and diminished oral health, but most longitudinal changes in oral health status were not significantly different than controls. Patients with AD are susceptible to a variety of oral health problems, and progression of AD can lead to a deterioration in oral health and function. These patients require aggressive preventive care to maintain function for as long as possible, which necessitates close cooperation among numerous health care professionals.

  11. Holographic complexity and fidelity susceptibility as holographic information dual to different volumes in AdS

    Directory of Open Access Journals (Sweden)

    N.S. Mazhari


    Full Text Available The holographic complexity and fidelity susceptibility have been defined as new quantities dual to different volumes in AdS. In this paper, we will use these new proposals to calculate both of these quantities for a variety of interesting deformations of AdS. We obtain the holographic complexity and fidelity susceptibility for an AdS black hole, Janus solution, a solution with cylindrical symmetry, an inhomogeneous background and a hyperscaling violating background. It is observed that the holographic complexity depends on the size of the subsystem for all these solutions and the fidelity susceptibility does not have any such dependence.

  12. Holographic complexity and fidelity susceptibility as holographic information dual to different volumes in AdS

    Energy Technology Data Exchange (ETDEWEB)

    Mazhari, N.S., E-mail: [Eurasian International Center for Theoretical Physics and Department of General & Theoretical Physics, Eurasian National University, Astana 010008 (Kazakhstan); Momeni, Davood, E-mail: [Eurasian International Center for Theoretical Physics and Department of General & Theoretical Physics, Eurasian National University, Astana 010008 (Kazakhstan); Bahamonde, Sebastian, E-mail: [Department of Mathematics, University College London, Gower Street, London, WC1E 6BT (United Kingdom); Faizal, Mir, E-mail: [Irving K. Barber School of Arts and Sciences, University of British Columbia - Okanagan, 3333 University Way, Kelowna, British Columbia, V1V 1V7 (Canada); Department of Physics and Astronomy, University of Lethbridge, Lethbridge, Alberta, T1K 3M4 (Canada); Myrzakulov, Ratbay, E-mail: [Eurasian International Center for Theoretical Physics and Department of General & Theoretical Physics, Eurasian National University, Astana 010008 (Kazakhstan)


    The holographic complexity and fidelity susceptibility have been defined as new quantities dual to different volumes in AdS. In this paper, we will use these new proposals to calculate both of these quantities for a variety of interesting deformations of AdS. We obtain the holographic complexity and fidelity susceptibility for an AdS black hole, Janus solution, a solution with cylindrical symmetry, an inhomogeneous background and a hyperscaling violating background. It is observed that the holographic complexity depends on the size of the subsystem for all these solutions and the fidelity susceptibility does not have any such dependence.

  13. Thermodynamic geometry and phase transitions of AdS braneworld black holes

    Energy Technology Data Exchange (ETDEWEB)

    Chaturvedi, Pankaj, E-mail:; Sengupta, Gautam, E-mail:


    The thermodynamics and phase transitions of charged RN–AdS and rotating Kerr–AdS black holes in a generalized Randall–Sundrum braneworld are investigated in the framework of thermodynamic geometry. A detailed analysis of the thermodynamics, stability and phase structures in the canonical and the grand canonical ensembles for these AdS braneworld black holes are described. The thermodynamic curvatures for both these AdS braneworld black holes are computed and studied as a function of the thermodynamic variables. Through this analysis we illustrate an interesting dependence of the phase structures on the braneworld parameter for these black holes.

  14. Google Advertising Tools Cashing in with AdSense and AdWords

    CERN Document Server

    Davis, Harold


    With this book, you'll learn how to take full advantage of Google AdWords and AdSense, the sophisticated online advertising tools used by thousands of large and small businesses. This new edition provides a substantially updated guide to advertising on the Web, including how it works in general, and how Google's advertising programs in particular help you make money. You'll find everything you need to work with AdWords, which lets you generate text ads to accompany specific search term results, and AdSense, which automatically delivers precisely targeted text and image ads to your website.

  15. Covariant charges in Chern-Simons AdS sub 3 gravity

    CERN Document Server

    Allemandi, G; Raiteri, M


    We try to give hereafter an answer to some open questions about the definition of conserved quantities in Chern-Simons theory, with particular reference to Chern-Simons AdS sub 3 gravity. Our attention is focused on the problem of global covariance and gauge invariance of the variation of Noether charges. A theory which satisfies the principle of covariance on each step of its construction is developed, starting from a gauge invariant Chern-Simons Lagrangian and using a recipe developed by Allemandi et al (2002 Class. Quantum Grav. 19 2633-55, 237-58) to calculate the variation of conserved quantities. The problem of giving a mathematical well-defined expression for the infinitesimal generators of symmetries is pointed out and it is shown that the generalized Kosmann lift of spacetime vector fields leads to the expected numerical values for the conserved quantities when the solution corresponds to the BTZ black hole. The fist law of black-hole mechanics for the BTZ solution is then proved and the transition b...

  16. A subjective scheduler for subjective dedicated networks (United States)

    Suherman; Fakhrizal, Said Reza; Al-Akaidi, Marwan


    Multiple access technique is one of important techniques within medium access layer in TCP/IP protocol stack. Each network technology implements the selected access method. Priority can be implemented in those methods to differentiate services. Some internet networks are dedicated for specific purpose. Education browsing or tutorial video accesses are preferred in a library hotspot, while entertainment and sport contents could be subjects of limitation. Current solution may use IP address filter or access list. This paper proposes subjective properties of users or applications are used for priority determination in multiple access techniques. The NS-2 simulator is employed to evaluate the method. A video surveillance network using WiMAX is chosen as the object. Subjective priority is implemented on WiMAX scheduler based on traffic properties. Three different traffic sources from monitoring video: palace, park, and market are evaluated. The proposed subjective scheduler prioritizes palace monitoring video that results better quality, xx dB than the later monitoring spots.

  17. The effect of directional inertias added to pelvis and ankle on gait (United States)


    Background Gait training robots should display a minimum added inertia in order to allow normal walking. The effect of inertias in specific directions is yet unknown. We set up two experiments to assess the effect of inertia in anteroposterior (AP) direction to the ankle and AP and mediolateral (ML) direction to the pelvis. Methods We developed an experimental setup to apply inertia in forward backward and or sideways directions. In two experiments nine healthy subjects walked on a treadmill at 1.5 km/h and 4.5 km/h with no load and with AP loads of 0.3, 1.55 and 3.5 kg to the left ankle in the first experiment and combinations of AP and ML loads on the pelvis (AP loads 0.7, 4.3 and 10.2 kg; ML loads 0.6, 2.3 and 5.3 kg). We recorded metabolic rate, EMG of major leg muscles, gait parameters and kinematics. Results & discussion Adding 1.55 kg or more inertia to the ankle in AP direction increases the pelvis acceleration and decreases the foot acceleration in AP direction both at speeds of 4.5 km/h. Adding 3.5 kg of inertia to the ankle also increases the swing time as well as AP motions of the pelvis and head-arms-trunk (HAT) segment. Muscle activity remains largely unchanged. Adding 10.2 kg of inertia to the pelvis in AP direction causes a significant decrease of the pelvis and HAT segment motions, particularly at high speeds. Also the sagittal back flexion increases. Lower values of AP inertia and ML inertias up to 5.3 kg had negligible effect. In general the found effects are larger at high speeds. Conclusions We found that inertia up to 2 kg at the ankle or 6 kg added to the pelvis induced significant changes, but since these changes were all within the normal inter subject variability we considered these changes as negligible for application as rehabilitation robotics and assistive devices. PMID:23597391

  18. Pagan, Pirate, Subject, Saint : Defining and Redefining Saxons, 150-900 A.D.

    NARCIS (Netherlands)

    Flierman, R.


    The student of the early medieval Saxons faces a number of methodological challenges. First, before the ninth century, the Saxons can only be known through reports composed by outsiders. Either Saxons left no writing of their own, or more likely, none of it survived. Second, what little reliable

  19. Comments on Cosmic Censorship in AdS/CFT

    Energy Technology Data Exchange (ETDEWEB)

    Hubeny, V.


    Recently Hertog, Horowitz, and Maeda (HHM) (hep-th/0310054) have proposed that cosmic censorship can be violated in the AdS/CFT context. They argue that for certain initial data there is insufficient energy available to make a black hole whose horizon is big enough to cloak the singularity that forms. We have investigated this proposal in the models HHM discuss and have thus far been unable to find initial data that provably satisfy this criterion, despite our development of an improved lower bound on the size of the singular region. This is consistent with recent numerical results (hep-th/0402109). For certain initial data, the energies of our configurations are not far above the lower bound on the requisite black hole mass, and so it is possible that in the exact time development naked singularities do form. We go on to argue that the finite radius cut-off AdS5 situation discussed by HHM displays instabilities when the full 10D theory is considered. We propose an AdS3 example that may well be free of this instability.

  20. Comments on Cosmic Censorship in AdS/CFT

    Energy Technology Data Exchange (ETDEWEB)

    Hubeny, Veronika E.; Liu, Xiao; Rangamani, Mukund; Shenker, Stephen


    Recently Hertog, Horowitz, and Maeda (HHM) (hep-th/0310054) have proposed that cosmic censorship can be violated in the AdS/CFT context. They argue that for certain initial data there is insufficient energy available to make a black hole whose horizon is big enough to cloak the singularity that forms. We have investigated this proposal in the models HHM discuss and have thus far been unable to find initial data that provably satisfy this criterion, despite our development of an improved lower bound on the size of the singular region. This is consistent with recent numerical results (hep-th/0402109). For certain initial data, the energies of our configurations are not far above the lower bound on the requisite black hole mass, and so it is possible that in the exact time development naked singularities do form. We go on to argue that the finite radius cut-off AdS_5 situation discussed by HHM displays instabilities when the full 10D theory is considered. We propose an AdS_3 example that may well be free of this instability.

  1. Inflation in AdS/CFT

    Energy Technology Data Exchange (ETDEWEB)

    Freivogel, Ben; /Stanford U., Phys. Dept. /LBL, Berkeley; Hubeny, Veronika E.; /LBL, Berkeley /Durham U., Dept. of Math.; Maloney, Alexander; /Stanford U., Phys. Dept.; Myers, Rob; /Perimeter Inst. Theor. Phys. /Waterloo U.; Rangamani, Mukund; /LBL, Berkeley /Durham U., Dept. of Math.; Shenker, Stephen; /Stanford U., Phys. Dept.


    We study the realization of inflation within the AdS/CFT correspondence. We assume the existence of a string landscape containing at least one stable AdS vacuum and a (nearby) metastable de Sitter state. Standard arguments imply that the bulk physics in the vicinity of the AdS minimum is described by a boundary CFT. We argue that large enough bubbles of the dS phase, including those able to inflate, are described by mixed states in the CFT. Inflating degrees of freedom are traced over and do not appear explicitly in the boundary description. They nevertheless leave a distinct imprint on the mixed state. Analytic continuation allows us, in principle, to recover a large amount of nonperturbatively defined information about the inflating regime. Our work also shows that no scattering process can create an inflating region, even by quantum tunneling, since a pure state can never evolve into a mixed state under unitary evolution.We study the realization of inflation within the AdS/CFT correspondence. We assume the existence of a string landscape containing at least one stable AdS vacuum and a (nearby) metastable de Sitter state. Standard arguments imply that the bulk physics in the vicinity of the AdS minimum is described by a boundary CFT. We argue that large enough bubbles of the dS phase, including those able to inflate, are described by mixed states in the CFT. Inflating degrees of freedom are traced over and do not appear explicitly in the boundary description. They nevertheless leave a distinct imprint on the mixed state. Analytic continuation allows us, in principle, to recover a large amount of nonperturbatively defined information about the inflating regime. Our work also shows that no scattering process can create an inflating region, even by quantum tunneling, since a pure state can never evolve into a mixed state under unitary evolution.

  2. Added value of qualitative studies in the development of health related patient reported outcomes such as the pain coping and cognition list in patients with sub-acute neck pain

    NARCIS (Netherlands)

    Pool, J.J.M.; Hiralal, S.; Ostelo, R.W.J.G.; van der Veer, K.; de Vet, H.C.W.


    Psychometric analyses, such as factor analysis, internal consistency and construct validity analysis, are well known and frequently applied methods in the development of health related patient reported outcomes. These statistical indexes shed very little light on how respondents interpret individual

  3. Application of the biospeckle method for monitoring bull's eye rot development and quality changes of apples subjected to various storage methods-preliminary studies

    National Research Council Canada - National Science Library

    Adamiak, Anna; Zdunek, Artur; Kurenda, Andrzej; Rutkowski, Krzysztof


    In this study, the biospeckle technique was evaluated for monitoring of apple bull's eye rot development and product quality in general, during storage under various conditions and during subsequent shelf life...

  4. Increased risk for diabetes development in subjects with large variation in total cholesterol levels in 2,827,950 Koreans: A nationwide population-based study.

    Directory of Open Access Journals (Sweden)

    Eun-Jung Rhee

    Full Text Available Recent studies suggest a role for hyperlipidemia in the development of diabetes. The aim of this study is to analyze the relationship between variations of total cholesterol (TC levels and the risk for type 2 diabetes development from a Korean nationwide population-based database.We examined the General Health Check-up sub-dataset of the Korean National Health Insurance Service (NHIS of 2,827,950 participants who had at least three health check-ups between 2002 and 2007, and were not reported to have diabetes during that time. The variations of TC levels between the examinations were calculated as follows: [Formula: see text]. The examinees were divided into 10 groups according to TC variation, and the hazard ratio for diabetes development from 2007 to 2013, were analyzed.During the follow-up period, 3.4% of the participants had developed diabetes. The hazard ratio (HR for diabetes development relative to the overall risk in the whole study population started to be higher than 1.0 from eighth decile of TC variation. The highest decile group showed an increased HR for diabetes development after adjustment for confounding variables (1.139; 95% confidence interval 1.116~1.163. These results were similar regardless of the use of anti-hyperlipidemic medication and baseline TC levels.The participants with a large variation in TC levels showed an increased risk for diabetes development, independent of the use of anti-hyperlipidemic medications. These results suggest a relationship between fluctuations in lipid levels and the development of type 2 diabetes.

  5. Rhazes (865-925 AD), the icon of Persian cardiology. (United States)

    Nezhad, Golnoush Sadat Mahmoudi; Dalfardi, Behnam


    For many long centuries, the function of the human cardiovascular system was an important issue among scholars of different eras and areas. Abubakr Muhammad ibn Zakariyya al-Razi (865-925 AD), known by the Latin name Rhazes, was one of the scholars concerned with this issue. This physician is recognized as the first great scientist of the Golden Age of Islamic Medicine (9th-12th centuries AD). He authored Kitab al-Mansuri (Liber Al-Mansuri), a ten-volume medical encyclopedia that covers a large number of medical subjects. The first chapter of this book is allocated to human anatomy and functions. In this article, we review the chapter from Al-Mansuri that deals with Rhazes' views on the cardiovascular system. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  6. Value-added Chemicals from Biomass by Heterogeneous Catalysis

    DEFF Research Database (Denmark)

    Voss, Bodil

    been implemented. The subject on chemical production has received less attention. This thesis describes and evaluates the quest for an alternative conversion route, based on a biomass feedstock and employing a heterogeneous catalyst capable of converting the feedstock, to a value-added chemical...... feedstock, having retained one C-C bond originating from the biomass precursor, the aspects of utilising heterogeneous catalysis for its conversion to value added chemicals is investigated. Through a simple analysis of known, but not industrialised catalytic routes, the direct conversion of ethanol...... deactivation of the Cu spinel catalyst may be concluded to be attributed to the formation of high molecular carbonaceous compounds covering the catalytic surface, being catalysed by acidic alumina sites present during and after catalyst activation. This theory explains several phenomena observed...

  7. A surface based approach for cortical thickness comparison between PiB+ and PiB- healthy control subjects (United States)

    Doré, Vincent; Bourgeat, Pierrick; Fripp, Jurgen; Acosta, Oscar; Chetelat, Gael; Szoeke, Cassandra; Ellis, Kathryn A.; Martins, Ralph N.; Villemagne, Victor; Masters, Colin L.; Ames, David; Rowe, Christopher C.; Salvado, Olivier


    β-amyloid has been shown to play a crucial role in Alzheimer's disease (AD). In vivo β-amyloid imaging using [11C]Pittsburgh compound Β (PiB) positron emission tomography has made it possible to analyze the relationship between β-amyloid deposition and different pathological markers involved in AD. PiB allows us to stratify the population between subjects which are likely to have prodromal AD, and those who don't. The comparison of the cortical thickness in these different groups is important to better understanding and detect the first symptoms of the disease which may lead to an earlier therapeutic care to reduce neurone loss. Several techniques have been developed to compare the cortical volume and/or thickness between AD and HC groups. However due to the noise introduced by the cortical thickness estimation and by the registration, these methods do not allow to unveil any major different when comparing prodromal AD groups with healthy control subjects group. To improve our understanding of where initial Alzheimer neurodegeneration occurs in the cortex we have developed a surface based technique, and have applied it to the discrimination between PIB-positive and PiB-negative HCs. We first identify the regions where AD patients show high cortical atrophy by using an AD/PiB- HC vertex-wise T-test. In each of these discriminating regions, comparison between PiB+ HC, PiB- HC and AD are performed. We found some significant differences between the two HC groups in the hippocampus and in the temporal lobe for both hemisphere and in the precuneus and occipital regions only for the left hemisphere.

  8. Adding New Colours to Interferometry (United States)


    Another vital step has been accomplished as planned towards full operation of the ESO Very Large Telescope Interferometer (VLTI) at the Paranal Observatory in Chile, one of the world's foremost astronomical facilities. In the night of March 20-21, 2004, a team of astronomers and engineers from France, Italy, Germany and ESO celebrated the successful assembly and completion of the first on-line tests of the latest of the first-generation VLTI instruments, the Astronomical Multiple BEam Recombiner (AMBER). They combined the two beams of light from the southern star Theta Centauri from two test telescopes ("siderostats" with 40-cm aperture, cf. ESO PR 06/01) to produce strong and clear interferometric fringes. Equally successful observations were then obtained on the bright star Sirius, and consistently repeated during the following nights. A joint project This is the most promising result of about 7 years of dedicated work by a team of over 40 astronomers and engineers. The AMBER instrument has been developed by a European consortium of seven research institutes in three ESO member countries, the main partners being: Laboratoire d'Astrophysique de Grenoble (LAOG), Laboratoire Universitaire d'Astrophysique de Nice (LUAN) and Observatoire de la Côte d'Azur in France, Max-Planck-Institut für Radioastronomie (MPIfR) in Bonn, Germany, and Osservatorio Astrofisico di Arcetri (OAA; part of INAF, the Italian National Institute for Astrophysics) in Florence, Italy. The total cost of AMBER is of the order of 5.9 million Euros, mostly contributed by the members of the consortium. It was built through an agreement with ESO, which rewards the consortium solely with guaranteed observing time. According to the contract, the consortium will receive 60 observing nights to be spread among two or three of the four 8.2-m VLT Unit Telescopes and 130 nights with the four Auxiliary Telescopes over a period of eight years. AMBER: soon to join three light beams at once ESO PR Photo 09a/04

  9. International Energy: Subject Thesaurus

    Energy Technology Data Exchange (ETDEWEB)

    Raridon, M.H. (ed.)


    The International Energy Subject Thesaurus contains the standard vocabulary to indexing terms (descriptors) developed and structured to build and maintain energy information databases. Involved in this cooperative task are (1) the technical staff of the USDOE Office of Scientific and Technical Information (OSTI) in cooperation with the member countries of the Energy Technology Data Exchange (ETDE) and (2) the International Nuclear Information System (INIS) staff representing the more than ninety countries and organizations recording and indexing information for the international nuclear information community. ETDE member countries are also members of the International Nuclear Information System (INIS). Nuclear information indexed and recorded for INIS by these ETDE member countries is also included in the ETDE Energy Data Base, and indexing terminology is therefore cooperatively standardized for use in both information systems. This structured vocabulary reflects the scope of international energy research, development, and technological programs and encompasses terminology derived not only from the basic sciences but also from the areas of energy resources, conservation, safety, environmental impact, and regulation.

  10. Quantum corrections to short folded superstring in AdS × S × M

    DEFF Research Database (Denmark)

    Beccaria, M.; Macorini, G.


    We consider integrable superstring theory on AdS × S × M where M = T or M = S × S with generic ratio of the radii of the two 3-spheres. We compute the one-loop energy of a short folded string spinning in AdS and rotating in S. The computation is performed by world-sheet small spin perturbation...... in the Bethe Ansatz. Remarkably, this contribution E turns out to be independent on the radii ratio. In the M = T limit, we discuss how E relates to a recent proposal for the dressing phase tested in the su(2) sector. We point out some difficulties suggesting that quantization of the AdS classical finite......-gap equations could be subtler than the easier AdS × S case....

  11. Orbiting strings in AdS black holes and N=4 SYM at finite temperature

    CERN Document Server

    Armoni, Adi; Petkou, Anastasios C


    Following Gubser, Klebanov and Polyakov [hep-th/0204051], we study strings in AdS black hole backgrounds. With respect to the pure AdS case, rotating strings are replaced by orbiting strings. We interpret these orbiting strings as CFT states of large spin similar to glueballs propagating through a gluon plasma. The energy and the spin of the orbiting string configurations are associated with the energy and the spin of states in the dual finite temperature N=4 SYM theory. We analyse in particular the limiting cases of short and long strings. Moreover, we perform a thermodynamic study of the angular momentum transfer from the glueball to the plasma by considering string orbits around rotating AdS black holes. We find that standard expectations, such as the complete thermal dissociation of the glueball, are borne out after subtle properties of rotating AdS black holes are taken into account.

  12. Fecal pollution in coastal marine sediments from a semi-enclosed deep embayment subjected to anthropogenic activities: an issue to be considered in environmental quality management frameworks development. (United States)

    González-Fernández, D; Garrido-Pérez, M C; Nebot-Sanz, E; Sales-Márquez, D


    Sewage discharge is a major source of pollution in marine environments. Urban wastewaters can directly enter marine environments carrying pathogen organisms, organic loads, and nutrients. Because marine sediments can act as the ultimate fate of a wide range of pollutants, environmental quality assessment in this compartment can help to identify pollution problems in coastal areas. In the present study, characterization of surficial marine sediments allowed assessment of fecal pollution in a semi-enclosed deep embayment that is subjected to anthropogenic activities. Physicochemical parameters and fecal indicators presented a great spatial heterogeneity. Fecal coliform and Clostridium perfringens showed accumulation in an extensive area, not only in proximity to sewage discharge points, but also in sediments at 100 meters depth. Results included herein demonstrated that, in coastal areas, urban wastewater discharge can affect the whole ecosystem through accumulation of fecal matter in bottom sediments. Application of multivariate techniques provided useful information with applicability for management of coastal areas in such complex systems. Environmental implications of wastewater discharge in coastal areas indicate the need to implement and include sediment quality control strategies in legislative frameworks.

  13. Applications of AdS/CFT in Quark Gluon Plasma

    NARCIS (Netherlands)

    Atmaja, Ardian Nata


    As one of the most important developments in string theory, the AdS/CFT correspondence(or in general gauge/gravity correspondence) encodes a way of using string theory to perform non-perturbative calculation in gauge theory which is still a complicated problem. It was firstly formulated as the

  14. VMQL: A Visual Language for Ad-Hoc Model Querying

    DEFF Research Database (Denmark)

    Störrle, Harald


    In large scale model based development, analysis level models are more like knowledge bases than engineering artifacts. Their effectiveness depends, to a large degree, on the ability of domain experts to retrieve information from them ad hoc. For large scale models, however, existing query facili...

  15. Heavy density liquid metal spallation target studies for Indian ADS ...

    Indian Academy of Sciences (India)

    An R&D programme has been initiated to address various physics and technology issues of ADS target. Under this programme, mercury and LBE experimental facilities are presently being set up. Along with these facilities, computational tools related to spallation physics (FLUKA) and CFD are being developed, and the ...

  16. Adding Value to Scholarly Journals through a Citation Indexing System (United States)

    Zainab, A. N.; Abrizah, A.; Raj, R. G.


    Purpose: The purpose of this paper is to relate the problems identified about scholarly journal publishing in Malaysia to establish motivation for the system development; to describe the design of MyCite, a Malaysian citation indexing system and to highlight the added value to journals and articles indexed through the generation of bibliometrics…

  17. The HOMA-Adiponectin (HOMA-AD) Closely Mirrors the HOMA-IR Index in the Screening of Insulin Resistance in the Brazilian Metabolic Syndrome Study (BRAMS) (United States)

    Cassani, Roberta Soares Lara; Forti, Adriana Costa e; Pareja, José Carlos; Tambascia, Marcos Antonio; Geloneze, Bruno


    Background The major adverse consequences of obesity are associated with the development of insulin resistance (IR) and adiposopathy. The Homeostasis Model Assessment-Adiponectin (HOMA-AD) was proposed as a modified version of the HOMA1-IR, which incorporates adiponectin in the denominator of the index. Objectives To evaluate the performance of the HOMA-AD index compared with the HOMA1-IR index as a surrogate marker of IR in women, and to establish the cutoff value of the HOMA-AD. Subjects/Methods The Brazilian Metabolic Syndrome Study (BRAMS) is a cross-sectional multicenter survey. The data from 1,061 subjects met the desired criteria: 18–65 years old, BMI: 18.5–49.9 Kg/m² and without diabetes. The IR was assessed by the indexes HOMA1-IR and HOMA-AD (total sample) and by the hyperglycemic clamp (n = 49). Metabolic syndrome was defined using the IDF criteria. Results For the IR assessed by the clamp, the HOMA-AD demonstrated a stronger coefficient of correlation (r = -0.64) compared with the HOMA1-IR (r = -0.56); p 0.05). The optimal cutoff identified for the HOMA-AD for the diagnosis of IR was 0.95. Conclusions The HOMA-AD index was demonstrated to be a useful surrogate marker for detecting IR among adult women and presented a similar performance compared with the HOMA1-IR index. These results may assist physicians and researchers in determining which method to use to evaluate IR in light of the available facilities. PMID:27490249

  18. The Development of Learning Processes by Direct Instruction Model and Peer – Assisted Learning achievement and attitude toward Thai Dancing Subject in Prathomsuksa 5

    Directory of Open Access Journals (Sweden)

    Saowari Phubanchuen


    Full Text Available The purposes of this study was to.. 1 study the expert’s opinion about teaching technique, teaching processes and the development of instrumental learning process on Dramatic Arts. 2 to develop the instrumental lesson plans using Direct Instruction Model and Peer Tutoring approach 3 to study the students learning outcome after using the developed lesson plans. The sample consists of 35 fifth grade students studying in Mahasarakham University Demonstration School (Elementary in 2016 Academic year using Cluster Random Sampling technique. Research toolsconsisted of 1 8 lesson plans. 2 Practical skills test and 3 chievement test. The collected data was analyzed by percentage Mean standardize score and Dependent Sample t-test The result of the study were as follow: 1. The expert’s opinion toward teaching Dramatic Arts suggest that the learning purposes and the nature of the course is the most important. Learning process has to encourage children to participate, and has served as both the audience and the performers. The good performances have been trained so they have needed skills in order to be confident and assertive plus having ability to criticism the show creatively. 2. The developed instrumental lesson plans using Direct Instruction Model and Peer Tutoring approach are appropriate in the highest level ( = 4.60. 3. The students learning outcome after using the developed lesson plans 3.1 developed instrumental lesson plans using Direct Instruction Model and Peer Tutoring approach had the Efficiency (E1/ E2 of 88.11 / 87.483.2 students’ practical skills after learning are more advanced with an average overall very satisfactory. 3.3 student achievement after learning increased from the previous level of statistical significance at level.05. 3.4 student satisfaction with the learning process using the learning management improved overall in most.

  19. Spontaneous ad hoc mobile cloud computing network. (United States)

    Lacuesta, Raquel; Lloret, Jaime; Sendra, Sandra; Peñalver, Lourdes


    Cloud computing helps users and companies to share computing resources instead of having local servers or personal devices to handle the applications. Smart devices are becoming one of the main information processing devices. Their computing features are reaching levels that let them create a mobile cloud computing network. But sometimes they are not able to create it and collaborate actively in the cloud because it is difficult for them to build easily a spontaneous network and configure its parameters. For this reason, in this paper, we are going to present the design and deployment of a spontaneous ad hoc mobile cloud computing network. In order to perform it, we have developed a trusted algorithm that is able to manage the activity of the nodes when they join and leave the network. The paper shows the network procedures and classes that have been designed. Our simulation results using Castalia show that our proposal presents a good efficiency and network performance even by using high number of nodes.

  20. Spontaneous Ad Hoc Mobile Cloud Computing Network

    Directory of Open Access Journals (Sweden)

    Raquel Lacuesta


    Full Text Available Cloud computing helps users and companies to share computing resources instead of having local servers or personal devices to handle the applications. Smart devices are becoming one of the main information processing devices. Their computing features are reaching levels that let them create a mobile cloud computing network. But sometimes they are not able to create it and collaborate actively in the cloud because it is difficult for them to build easily a spontaneous network and configure its parameters. For this reason, in this paper, we are going to present the design and deployment of a spontaneous ad hoc mobile cloud computing network. In order to perform it, we have developed a trusted algorithm that is able to manage the activity of the nodes when they join and leave the network. The paper shows the network procedures and classes that have been designed. Our simulation results using Castalia show that our proposal presents a good efficiency and network performance even by using high number of nodes.