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Sample records for subject indexes lp

  1. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Subject Index. Variation of surface electric field during geomagnetic disturbed period at Maitri, Antarctica. 1721. Geomorphology. A simple depression-filling method for raster and irregular elevation datasets. 1653. Decision Support System integrated with Geographic. Information System to target restoration actions in water-.

  2. Determining the group velocity dispersion by field analysis for the LP0X, LP1X, and LP2X mode groups independently of the fiber length: applications to step-index fibers

    DEFF Research Database (Denmark)

    Israelsen, Stine Møller; Usuga Castaneda, Mario A.; Rottwitt, Karsten

    2017-01-01

    By knowing the electric field distribution of a guided mode in an optical fiber, we are able to evaluate the group velocity dispersion in a weakly guiding step-index fiber for a pure mode in the LP0X, LP1X, and LP2X mode groups independently of the fiber length. We demonstrate the method...

  3. SUBJECT AND AUTHOR INDEXS

    Directory of Open Access Journals (Sweden)

    IJBE Volume 1

    2015-09-01

    Full Text Available SUBJECT INDEX IJBE VOLUME 1EPA, 1Agrotourism, 148AHP, 148balance scorecard, 63batik tulis Rolla Junior, 23Broiler, 90business model canvas, 137business performance,32capital structure, 81cashew industry,158CHAID,106CLI,42coal transportation service,63company’s characteristics, 81competitive advantage, 12competitive strategy, 127consumer satisfaction, 51CSI, 42customer loyalty, 42customer satisfaction,42decision of visitors, 72development strategy, 23development,158entrepreneurship, 32Feasibility studies, 90FEM, 81gap analysis, 1Indonesia Stock Exchange, 177Indosat, 137investor,177Kawah Putih, 72kedai sop durian lodaya (KSDL,51klassen typology, 96leading sector, 96less cash society, 137liquidity ratio, 165location quotient, 96logistic regression, 115market, 177marketing development strategy, 148Marketing mix, 72mobile payment, 137modern and Traditional cage, 90multiple regression analyse,165multiple regression, 177net working capital, 165organic tofu product, 115Padang, 106paired comparison, 63partnership, 1, 32Pecking Order Theory, 81PLS, 81Portfolio, 96power, 32product quality, 51profitability ratio, 165Prol Tape Primadona, 127purchase decision, 115purchase intention, 51purchasing interest,115QSPM, 23, 127refilled drinking water, 106seed,1segmentation, 106SEM, 42, 51service quality, 51SMEs, 96specialty coffee, 12stock,177strategic diagnosis,137strategy, 158Sukorambi Botanic Garden, 148SWOT, 23, 127, 148, 158SWOT-AHP, 12tourists,72UD. Primadona, 127value chain, 12VRIO,12 AUTHOR INDEX IJBE VOLUME 1Adiningsih, Kartika Puspitasari,42Aknesia, Vharessa,12Amalia, Firda Rachma,90Andati, Trias, 177Anggraeni, Lukytawati,23Asriani,158Daryanto, Arief,12, 90Djamaludin, MD., 42Djohar, Setiadi,96Fachrodji, Achmad,72Fahmi, Idqan,1, 63, 127Fasyni, Awisal,106Hubeis, Musa,148Iskandar, Dodi,51Juanda, Bambang, 165Kirbrandoko, 12, 106, 115Lumbantoruan, Dewi Margareth,96Maulana, TB Nur Ahmad,81Muksin, 148Mukti Soleh, Cecep,63Najib, Mukhamad,106Noor, Tajudin,81

  4. SUBJECT AND AUTHOR INDEXS

    Directory of Open Access Journals (Sweden)

    IJBE Volume 2

    2016-09-01

    Full Text Available SUBJECT INDEX IJBE VOLUME 2access credit, 93acquisition, 177AHP, 61, 82, 165arena simulation,43BMC, 69Bojonegoro, 69brand choice, 208brand image, 208brand positioning, 208bullwhip effect, 43burger buns, 1business synergy and financial reports, 177capital structure, 130cluster, 151coal reserves, 130coffee plantation, 93competitiveness, 82consumer behaviour, 33consumer complaint behavior, 101cooking spices, 1crackers, 1cross sectional analytical, 139crosstab, 101CSI, 12direct selling, 122discriminant analysis, 33economic value added, 130, 187employee motivation, 112employee performance, 112employees, 139EOQ, 23farmer decisions, 93farmer group, 52financial performance evaluation, 187financial performance, 52, 177financial ratio, 187financial report, 187fiva food, 23food crops, 151horticulture, 151imports, 151improved capital structure, 177IPA, 12leading sector, 151life insurance, 165LotteMart, 43main product, 61marketing mix, 33, 165matrix SWOT, 69MPE, 61multiple linear regression, 122muslim clothing, 197Ogun, 139Pangasius fillet, 82Pati, 93pearson correlation, 101perceived value, 208performance suppy chain, 23PLS, 208POQ, 23portfolio analyzing, 1product, 101PT SKP, 122pulp and papers, 187purchase decision, 165purchase intention, 33remuneration, 112re-purchasing decisions, 197sales performance, 122sawmill, 52SCOR, 23sekolah peternakan rakyat, 69SEM, 112SERVQUAL, 12Sido Makmur farmer groups, 93SI-PUHH Online, 12small and medium industries (IKM, 61socio-demographic, 139sport drink, 208stress, 139supply chain, 43SWOT, 82the mix marketing, 197Tobin’s Q, 130trade partnership, 52uleg chili sauce, 1 AUTHOR INDEX IJBE VOLUME 2Achsani, Noer Azam, 177Andati, Trias, 52, 177Andihka, Galih, 208Arkeman, Yandra, 43Baga, Lukman M, 69Cahyanugroho, Aldi, 112Daryanto, Arief, 12David, Ajibade, 139Djoni, 122Fahmi, Idqan, 1Fattah, Muhammad Unggul Abdul, 61Hakim, Dedi Budiman, 187Harianto, 93Hartoyo, 101Homisah, 1Hubeis, Musa, 112Hutagaol, M. Parulian, 93Jaya, Stevana

  5. Proceedings (Mathematical Sciences) SUBJECT INDEX

    Indian Academy of Sciences (India)

    Rigidity of minimal submanifolds with flat normal bundle. 457. Min-max property. John disks, the Apollonian metric, and min-max properties. 83. Mixed norm. Mixed norm estimate for Radon transform on weighted Lp spaces. 441. Modular equation. Theta function identities associated with Ramanujan's modular equations of.

  6. Increased risk of coronary artery calcification progression in subjects with high baseline Lp(a) levels: The Kangbuk Samsung Health Study.

    Science.gov (United States)

    Cho, Jung Hwan; Lee, Da Young; Lee, Eun Seo; Kim, Jihyun; Park, Se Eun; Park, Cheol-Young; Lee, Won-Young; Oh, Ki-Won; Park, Sung-Woo; Rhee, Eun-Jung

    2016-11-01

    Results from previous studies support the association of lipoprotein(a) [Lp(a)] levels and coronary artery disease risk. In this study, we analyzed the association between baseline Lp(a) levels and future progression of coronary artery calcification (CAC) in apparently healthy Korean adults. A total of 2611 participants (mean age: 41years, 92% mend) who underwent a routine health check-up in 2010 and 2014 were enrolled. Coronary artery calcium score (CACS) were measured by multi-detector computed tomography. Baseline Lp(a) was measured by high-sensitivity immunoturbidimetric assay. Progression of CAC was defined as a change in CACS >0 over four years. Bivariate correlation analyses with baseline Lp(a) and other metabolic parameters revealed age, total cholesterol, HDL-C, LDL-C and CACS to have a significant positive correlation, while body weight, fasting glucose level, blood pressure and triglyceride level were negatively correlated with baseline Lp(a) level. After four years of follow-up, 635 subjects (24.3%) had CAC progression. The participants who had CAC progression were older, composed of more men, more obese, and had higher fasting glucose levels and worse baseline lipid profiles compared to those who did not have CAC progression. The mean serum Lp(a) level was significantly higher in subjects who had CAC progression compared to those who did not (32.5 vs. 28.9mg/dL, p<0.01). When the risk for CAC progression according to baseline Lp(a) was calculated, those with Lp(a) level≥50mg/dL had an odds ratio of 1.333 (95% CI 1.027-1.730) for CAC progression compared to those with Lp(a)<50mg/dL after adjusting for confounding factors. In this study, the subjects who had higher Lp(a) were at significantly higher risk for CAC progression after four years of follow-up, suggesting the role of high Lp(a) in CAC progression. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  7. The Lp Lp Lp-curvature images of convex bodies and Lp Lp Lp ...

    Indian Academy of Sciences (India)

    Abstract. Associated with the Lp-curvature image defined by Lutwak, some inequali- ties for extended mixed p-affine surface areas of convex bodies and the support functions of Lp-projection bodies are established. As a natural extension of a result due to Lutwak, an Lp-type affine isoperimetric inequality, whose special ...

  8. Evaluating the Streif index against commercial subjective ...

    African Journals Online (AJOL)

    Historical physiological data for Golden Delicious and Starking apples (Malus domestica Borkh.) from various orchards in the Ceres area were analysed. Significant correlations were obtained between the SI and subjective predictions of the release date for harvesting, after adapting the local starch breakdown values.

  9. Investigation of the Brain Biodistribution of the Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitor [(18)F]GSK2647544 in Healthy Male Subjects.

    Science.gov (United States)

    Huiban, Mickael; Coello, Christopher; Wu, Kai; Xu, Yanmei; Lewis, Yvonne; Brown, Andrew P; Buraglio, Mauro; Guan, Chenbing; Shabbir, Shaila; Fong, Regan; Passchier, Jan; Rabiner, Eugenii A; Lockhart, Andrew

    2017-02-01

    GSK2647544 is a potent and specific inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), which was in development as a potential treatment for Alzheimer's disease (AD). In order to refine therapeutic dose predictions and confirm brain penetration, a radiolabelled form of the inhibitor, [(18)F]GSK2647544, was manufactured for use in a positron emission tomography (PET) biodistribution study. [(18)F]GSK2647544 was produced using a novel, copper iodide (Cu(I)) mediated, [(18)F]trifluoromethylation methodology. Healthy male subjects (n = 4, age range 34-42) received an oral dose of unlabelled GSK2647544 (100 mg) and after 2 h an intravenous (iv) injection of [(18)F]GSK2647544 (average injected activity and mass were 106 ± 47 MBq and 179 ± 55 μg, respectively) followed by dynamic PET scans for 120 min. Defined regions of interest (ROI) throughout the brain were used to obtain regional time-activity curves (TACs) and compartmental modelling analysis used to estimate the primary outcome measure, whole brain volume of distribution (VT). Secondary PK and safety endpoints were also recorded. PET dynamic data were successfully obtained from all four subjects and there were no clinically significant variations of the safety endpoints. Inspection of the TACs indicated a relatively homogenous uptake of [(18)F]GSK2647544 across all the ROIs examined. The mean whole brain VT was 0.56 (95 % CI, 0.41-0.72). Secondary PK parameters, Cmax (geometric mean) and Tmax (median), were 354 ng/ml and 1.4 h, respectively. Metabolism of GSK2647544 was relatively consistent across subjects, with 20-40 % of the parent compound [(18)F]GSK2647544 present after 120 min. The study provides evidence that GSK2647544 is able to cross the blood brain barrier in healthy male subjects leading to a measurable brain exposure. The administered doses of GSK2647544 were well tolerated. Exploratory modelling suggested that a twice-daily dose of 102 mg, at steady state, would

  10. Introduction to Subject Indexing; a Programmed Text. Volume Two: UDC and Chain Procedure in Subject Cataloguing.

    Science.gov (United States)

    Brown, A. G.; And Others

    This is the second of two volumes dealing with practical classification and subject indexing. The programed text considers use of the Universal Decimal Classification (UDC) and techniques of cross referencing based on UDC in the construction of classified and alphabetical subject catalogs. (Author/LS)

  11. The Integrative Weaning Index in Elderly ICU Subjects.

    Science.gov (United States)

    Azeredo, Leandro M; Nemer, Sérgio N; Barbas, Carmen Sv; Caldeira, Jefferson B; Noé, Rosângela; Guimarães, Bruno L; Caldas, Célia P

    2017-03-01

    With increasing life expectancy and ICU admission of elderly patients, mechanical ventilation, and weaning trials have increased worldwide. We evaluated a cohort with 479 subjects in the ICU. Patients younger than 18 y, tracheostomized, or with neurologic diseases were excluded, resulting in 331 subjects. Subjects ≥70 y old were considered elderly, whereas those elderly. Besides the conventional weaning indexes, we evaluated the performance of the integrative weaning index (IWI). The probability of successful weaning was investigated using relative risk and logistic regression. The Hosmer-Lemeshow goodness-of-fit test was used to calibrate and the C statistic was calculated to evaluate the association between predicted probabilities and observed proportions in the logistic regression model. Prevalence of successful weaning in the sample was 83.7%. There was no difference in mortality between elderly and non-elderly subjects (P = .16), in days of mechanical ventilation (P = .22) and days of weaning (P = .55). In elderly subjects, the IWI was the only respiratory variable associated with mechanical ventilation weaning in this population (P elderly subjects that may contribute to the critical moment of this population in intensive care. Copyright © 2017 by Daedalus Enterprises.

  12. Dapsone and body mass index in subjects with multibacillary leprosy.

    Science.gov (United States)

    Moura, Fernanda M L; Dias, Rosa M; Araujo, Eliete C; Brasil, Laélia M B F; Ferreira, Michelle V D; Vieira, Jose L F

    2014-04-01

    The physiological changes in obese subjects can modify the pharmacokinetic profiles of drugs influencing the therapeutic efficacy. In this study, the authors compare plasma dapsone trough levels of multibacillary leprosy subjects stratified by body mass index (BMI) to evaluate if obesity plays a significant role on drug levels. The relationship between drug levels and BMI was also determined. Dapsone was measured by high-performance liquid chromatography and BMI based on World Health Organization criteria. At steady state, the median plasma dapsone trough level was significantly lower in obesity class 2 group, when compared with other groups, but they were similar between normal weight and preobesity groups. A weak association between drug levels and BMI was observed. Obesity promotes a significant reduction in plasma dapsone trough levels of subjects with multibacillary leprosy with a weak association between drug levels and BMI.

  13. Accuracy of medical subject heading indexing of dental survival analyses.

    Science.gov (United States)

    Layton, Danielle M; Clarke, Michael

    2014-01-01

    To assess the Medical Subject Headings (MeSH) indexing of articles that employed time-to-event analyses to report outcomes of dental treatment in patients. Articles published in 2008 in 50 dental journals with the highest impact factors were hand searched to identify articles reporting dental treatment outcomes over time in human subjects with time-to-event statistics (included, n = 95), without time-to-event statistics (active controls, n = 91), and all other articles (passive controls, n = 6,769). The search was systematic (kappa 0.92 for screening, 0.86 for eligibility). Outcome-, statistic- and time-related MeSH were identified, and differences in allocation between groups were analyzed with chi-square and Fischer exact statistics. The most frequently allocated MeSH for included and active control articles were "dental restoration failure" (77% and 52%, respectively) and "treatment outcome" (54% and 48%, respectively). Outcome MeSH was similar between these groups (86% and 77%, respectively) and significantly greater than passive controls (10%, P indexed as such. Significantly more time-related MeSH were allocated to the included than the active controls (92% and 79%, respectively, P = .02), or to the passive controls (22%, P < .001). MeSH allocation within MEDLINE to time-to-event dental articles was inaccurate and inconsistent. Statistical MeSH were omitted from 30% of the included articles and incorrectly allocated to 15% of active controls. Such errors adversely impact search accuracy.

  14. On indexes and subject matter of “global competitiveness”

    Directory of Open Access Journals (Sweden)

    A. V. Korotkov

    2017-01-01

    Full Text Available The aim of the research is to analyze the subject matter of a country’s competitiveness and to characterize statistical indexes of competitiveness known in the international practice from the perspective of a more elaborated theory of market competition. This aim follows from the identified problems. First, there are no generally accepted interpretation and joint understanding of competition and competitiveness at country level. Even the international organizations giving estimations of global competitiveness disagree on definitions of competitiveness. Secondly, there is no relation to the theory of market competition in the available source materials on competitiveness of the country without original methodology. Thirdly, well-known statistical indexes of global competitiveness do not have enough theoretical justification and differ in sets of factors. All this highlights the incompleteness of the methodology and methodological support of studying competitiveness at country level.Materials and methods. The research is based on the methodology of statistics, economic theory and marketing. The authors followed the basic principle of statistical methodology – requirement of continuous combination of qualitative and quantitative analysis, when the research begins and ends with qualitative analysis. A most important section of statistical methodology is widely used – construction of statistical indexes. In the course of the analysis, a method of statistical classifications is applied. A significant role in the present research is given to the method of generalizing and analogue method, realizing that related terms should mean similar and almost similar contents. Modeling of competition and competitiveness is widely used in the present research, which made it possible to develop a logical model of competition following from the competition theory.Results. Based on the definitions’ survey the analysis of the subject matter of global

  15. Lp Lp Lp-mixed intersection bodies and star duality

    Indian Academy of Sciences (India)

    Lutwak introduced mixed projection bodies and derived their fundamental inequalities. In 1999, Moszynska [28] introduced the notion of star dual of star body. Recently,. Haberl and Ludwig [16] introduced Lp-intersection bodies. Following Haberl, Ludwig and Moszynska, the paper introduces a new concept of q-dual mixed ...

  16. Higher Body Mass Index Is Associated with Subjective Olfactory Dysfunction

    Directory of Open Access Journals (Sweden)

    Z. M. Patel

    2015-01-01

    Full Text Available Background. Morbidly obese patients demonstrate altered olfactory acuity. There has been no study directly assessing Body Mass Index (BMI in patients with olfactory dysfunction. Our purpose was to compare BMI in a group of patients with subjective olfactory dysfunction to those without subjective olfactory complaints. Methods. Retrospective matched case-control study. Sixty patients who presented to a tertiary care otolaryngology center with subjective smell dysfunction over one year were identified. Neoplastic and obstructive etiologies were excluded. Demographics, BMI, and smoking status were reviewed. Sixty age, gender, and race matched control patients were selected for comparison. Chi-square testing was used. Results. 48 out of 60 patients (80% in the olfactory dysfunction group fell into the overweight or obese categories, compared to 36 out of 60 patients (60% in the control group. There was a statistically significant difference between the olfactory dysfunction and control groups for this stratified BMI (p= 0.0168.  Conclusion. This study suggests high BMI is associated with olfactory dysfunction. Prospective clinical research should examine this further to determine if increasing BMI may be a risk factor in olfactory loss and to elucidate what role olfactory loss may play in diet and feeding habits of obese patients.

  17. A red yeast rice-olive extract supplement reduces biomarkers of oxidative stress, OxLDL and Lp-PLA2, in subjects with metabolic syndrome: a randomised, double-blind, placebo-controlled trial.

    Science.gov (United States)

    Hermans, Nina; Van der Auwera, Anastasia; Breynaert, Annelies; Verlaet, Annelies; De Bruyne, Tess; Van Gaal, Luc; Pieters, Luc; Verhoeven, Veronique

    2017-07-03

    Metabolic syndrome (MetS) refers to clustered cardiovascular risk factors (abdominal obesity, pre-diabetes, high blood pressure, dyslipidaemia). Therapies targeting oxidative stress may delay progression to atherosclerosis and diabetes. We investigated the anti-oxidative effect of a supplement combining red yeast rice and olive extract in patients with MetS. A double-blind, placebo-controlled, randomised trial was conducted with 50 patients with MetS as defined by National Cholesterol Education Program Adult Treatment Panel III criteria. Forty-nine subjects randomly assigned to red yeast rice-olive extract (RYR-olive extract; 10.82 mg of monacolins and 9.32 mg of hydroxytyrosol per Cholesfytolplus capsule) or placebo completed the 8-week trial. Whereas effects on cardiovascular risk parameters of MetS have been reported recently, the observed significant 20% increase in oxidised low-density lipoprotein (OxLDL) prompted us to investigate other oxidative stress-related parameters: malondialdehyde (MDA), lipoprotein-associated phospholipase A2 (Lp-PLA2) and 8-hydroxy-2'-deoxyguanosine (8-OHdG). Statistical calculations included univariate quantitative analysis, multivariate linear regression and correlation analysis. The updated results indicate that an RYR-olive extract supplement significantly reduced Lp-PLA2 by 7% (p  0.05). Reductions in OxLDL (20%) and Lp-PLA2 (7%) were associated with each other (r = 0.740, p < 0.001). RYR-olive extract significantly reduced Lp-PLA2 in correlation with the marked reduction in plasma OxLDL, which may lead to a reduced risk for cardiovascular disease in patients with MetS. ClinicalTrials.gov identifier: NCT02065180 . Registered on 13 February 2014.

  18. Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index

    DEFF Research Database (Denmark)

    Aller, E E J G; Larsen, Thomas Meinert; Holst, Claus

    2014-01-01

    -month intervention period.Results:During the LCD period subjects lost 11.2 (10.8, 12.0) kg (mean (95% CI)). Average weight regain over the 12-month intervention period was 3.9 (95% CI 3.0 to 4.8) kg. Subjects on the HP diets regained less weight than subjects on the LP diets. The difference in weight......Background:A high dietary protein (P) content and low glycemic index (GI) have been suggested to be beneficial for weight management, but long-term studies are scarce.Objective:The DIOGENES randomized clinical trial investigated the effect of P and GI on weight loss maintenance in overweight...

  19. CORN, LP Goldfield Approval

    Science.gov (United States)

    This November 19, 2015 letter from EPA approves the petition from CORN, LP, Goldfield facility, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel (D-code 6) RINs under the RFS pro

  20. Isometric multipliers of Lp(G, X) Lp(G, X) Lp(G, X)

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    Abstract. Let G be a locally compact group with a fixed right Haar measure and X a separable Banach space. Let Lp(G, X) be the space of X-valued measurable functions whose norm-functions are in the usual Lp . A left multiplier of Lp(G, X) is a bounded linear operator on Lp(G, X) which commutes with all left translations.

  1. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Administrator

    sensor for methanol determination in the gas phase. 703. Electrochemically active surface area. Platinum-carbon black-titanium dioxide nanocompo- site electrocatalysts for fuel cell applications. 655. Electrochemistry. Synthesis, spectroscopic and redox properties of the mononuclear Ni. II. , Ni. II. (BPh2)2 containing (B–C) ...

  2. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Amery Ice Shelf. Study of inter-annual variations in surface melting over. Amery Ice Shelf, East Antarctica, using space-borne scatterometer data. 329. Ammonium. Measurement of marine productivity using 15N and 13C tracers: Some methodological aspects. 99. Anabatic and katabatic wind. Study of vertical wind profiles in ...

  3. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Leibnitz series (2) 116 (GA). Guaiacum officinale L. (6) (FT). Gun-powder (11) 1009 (SA). Gust loads (3) 206 (SA). Gyrocarpus americanus Jacq. (12) FT. Handicap principle (5) 434 (GA). Hands-on learning (4) 351 (CR). Heisenberg (5) 411 (GA).

  4. SUBJECT INDEX

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    ? 831. India. Folds in multilayered rocks of Proterozoic age,. Rajasthan, India. 299. Trace element geochemistry of Amba Dongar carbonatite complex, India: Evidence for frac- tional crystallization and silicate-carbonate melt immiscibility. 519.

  5. SUBJECT INDEX

    Indian Academy of Sciences (India)

    179. Arabian Sea. Improved bathymetric datasets for the shallow water regions in the Indian Ocean. 261. Vertical propagation of baroclinic Kelvin waves along the west coast of India. 331. Arabian Sea Monsoon Experiment (ARMEX). Surface and upper air meteorological features during onset phase of 2003 monsoon. 305.

  6. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Landsat 7 ETM+ image in and around Kuju volcano,. Kyushu, Japan. 1049. Metallogenic epoch of the Jiapigou gold belt, Jilin. Province, China: Constrains from rare earth element, fluid inclusion geochemistry and geochronology. 1401. Ninety million years of orogenesis, 250 million years of quiescence and then further ...

  7. Subject Index

    Indian Academy of Sciences (India)

    user1

    Role of Gas Dynamical Friction in the Evolution of Embedded Stellar Clusters (K. Indulekha), 207. Puzzling Origin of CEMP-r/s Stars: An Interpretation of Abundance and Enrichment of s- and r-Process Elements from Asymptotic Giant Branch Supernovae. (Jiang Zhang, Fang Zhao, Yanping Chen, Wenyuan Cui & Bo Zhang) ...

  8. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Administrator

    A solid-polymer-electrolyte direct methanol fuel cell. (DMFC) with Pt–Ru nanoparticles supported onto poly(3,4-ethylenedioxythiophene) and polystyrene sulphonic acid polymer composite as anode. 381. CD spectroscopy. Studies on interaction between CdTe quantum dots and α-chymotrypsin by molecular spectroscopy ...

  9. Subject Index

    Indian Academy of Sciences (India)

    Peter A. Gilman), 29. Prediction of Peaks in Wolf Numbers in Cycle 24 according to Actual Numbers of. Polar Faculae (D. K. Callebaut & V. V. Makarova), 69. Prospects for Predicting Cycle 24 (Arnab Rai Choudhuri), 41. Solar Astronomy. Keynote Address: Outstanding Problems in Solar Physics (Markus J. Aschwanden), 3.

  10. SUBJECT INDEX

    Indian Academy of Sciences (India)

    WINTEC

    inflammatory activity. Solvent-free microwave-assisted synthesis of oxadia- zoles containing imidazole moiety. 41. Antimicrobial activity. Synthesis, spectral characterization of Schiff base transition metal complexes: DNA cleavage and anti- microbial ...

  11. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Unknown

    Generalized density-functional theory: Conquering the N-representability problem with exact functionals for the electron pair density and the second-order re- duced density matrix. 507. Chemical reactivity of hypervalent silicon com- pounds: The local hard and soft acids and bases prin- ciple viewpoint. 525. A philicity based ...

  12. Subject Index

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    Photometric Variability of Four Coronally Active Stars (J. C. Pandey, K. P. Singh,. R. Sagar & S. A. Drake), 9. The Investigation of Nova-like Variable MV Lyr during the 1999–2001 Years. (N. A. Katysheva, S. Yu. Shugarov, E. P. Pavlenko & P. V. Abolmasov), 15. Sun, interior. Seismic View of the Solar Interior (H. M. Antia), 3.

  13. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Creative research in the chemical industry – Four decades in retrospect. 291. Crystal structure. Two new polyoxovanadate clusters templated through cysteamine. 159. A chiral Mn(IV) complex and its supramolecular as- sembly: Synthesis, characterization and properties 311 meso-Tetrathienylporphyrins: Steady-state ...

  14. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Precipitation reconstruction using ring-width chronology of Himalayan cedar from western Himalaya: ... Fishery industry. Seasonal variability of sea surface chlorophyll-a of waters around Sri Lanka. 427. Fluorescence. Bio-optical properties of gelbstoff in the Arabian Sea at the onset of the southwest monsoon. 415. Flux.

  15. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Cu/SiO2 catalysts that contain copper phyllosilicate 1013. Ethylenediaminetetraacetic acid. Functionalization of lambda-zirconium phosphate with ethylenediaminetetraacetic acid: Synthesis, characteriza- tion and applications. 1721. Expanded porphyrins. Sulfonated graphenes catalyzed synthesis of expanded porphyrins ...

  16. Subject Index

    Indian Academy of Sciences (India)

    Some Doubts on the Validity of the Foreground Galactic Contribution Subtraction from Microwave Anisotropies (Martın López-Corredoira), 101. Effects of the Size of Cosmological N-body Simulations on Physical Quantities – II: Halo Formation and Destruction Rate (Jayanti Prasad), 117. Extragalactic Astronomy. Kinematical ...

  17. Subject Index

    Indian Academy of Sciences (India)

    user1

    ... Spectra Variability of BL Lacertae Object S5 0716+714 (Zhang Hao. Jing, Zhao Gang, Zhang Xiong, Bai Jing Ming, Tang Ling & Xu Yun Bing), 131. Part 3. Blazar Observations in High Energy Bands. Gamma-Ray and Multiwavelength Emission from Blazars (Meg Urry), 139. Quasi-Periodic Oscillations in the X-ray Light ...

  18. Subject Index

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    GMRT detection of HI 21 cm-line Absorption from the Peculiar Galaxy in Abell 2125. (K. S. Dwarakanath & F. N. Owen), 1. Hard X-ray Spectrum of Mkn 421 during the Active Phase (R. K. Manchanda), 145. Hα Emission Line Morphologies in Markarian Starburst Galaxies (A. Chitre &. U. C. Joshi), 155. Soft X-ray variability of ...

  19. SUBJECT INDEX

    Indian Academy of Sciences (India)

    resolution satellite image segmentation using. Hölder exponents. 609. Coal ... satellite observations. 441. Eastern continental margin of India. Magnetic anomalies of offshore Krishna–Godavari basin, eastern continental margin of India. 405. Ecology.

  20. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Unknown

    Cyclodextrin. Regioselective photamination of 4-nitrovera- trole upon cyclodextrin complexation. 273. Cyclohexanone. Hydrogen transfer reaction of cyclohexanone with 2-propanol catalysed by CeO2-ZnO materials: Promoting effect of ceria. 561. DFT. Measures to evaluate heteroaromaticity and their limitations: Story of ...

  1. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Wintec

    Microdetermination of human serum albumin by dif- ferential pulse voltammetry at a L-cysteine modified silver electrode. 419 β-Cyclodextrin. Guest–host interactions in the cleavage of phenyl- phenyl acetates by β-cyclodextrin in alkaline medium. 325 a-Diketones. Microwave-assisted efficient oxidation of internal al-.

  2. Subject Index

    Indian Academy of Sciences (India)

    tribpo

    Dynamical processes in flux tubes and their role in chromospheric heating. (S. S. Hasan), 283. Models of flux tubes from constrained relaxation. (A. Mangalam & V. Krishan), 299. Magnetoconvection and the solar dynamo (A. Nordlund, S. B. F. Dorch &. R. F. Stein), 307. Large scale flow and transport of magnetic flux in the ...

  3. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Unknown

    Fluorescence studies. Covalently linked bisporphyrins bearing tetraphenyl- porphyrin and perbromoporphyrin units: Synthesis and their properities. 71. Fraction of adsorption. Adsorption dynamics ans equilibrium studies of Zn(II) onto chitosan. 119. Furan amino acids. Sugar amino acids and related molecules: Some recent.

  4. Subject Index

    Indian Academy of Sciences (India)

    ray. Spectrometer (SOXS) Mission ... Luminosity Dependent Study of the High Mass X-ray Binary Pulsar 4U 0114 + 65 with ASCA (U. Mukherjee & B. ... Magnetic Source Regions of Coronal Mass Ejections (Brigitte Schmieder), 139. North–South ...

  5. SUBJECT INDEX

    Indian Academy of Sciences (India)

    protected areas of Rajasthan, India. 467. Geochemistry. Geochemical constraints on the evolution of mafic and felsic rocks in the Bathani volcanic and volcano- sedimentary sequence of Chotanagpur Granite Gneiss. Complex. 959. Identification and characterization of tsunami deposits off southeast coast of India from the ...

  6. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Unknown

    high average power TEA CO2 laser. 659. Carpaine. Five decades ... cal properties of transition metal complexes containing semiquinonate .... (5HI): Laser flash photolysis study. 547. Five-membered chelate ring. Thiosemicarbozene complexes of platinum metals. A story of variable coordination modes. 255. Fluorescence.

  7. SUBJECT INDEX

    Indian Academy of Sciences (India)

    user

    Conservation biology (7) 627 (GA). Controllability (11) 1009 (SA). Convection (7) 638 (GA). Correlation coefficient (10) 978 (TIO). Cosmology (4) 319 (GA) ..... Thiazolium salt catalysis (4) 355 (GA). Thomas precession (8) 706 (SA). Tiliacorine (6) 520 (GA). Tilt rotor (9) 836 (SA). Time (9) 844 (GA). Time, Love, Memory: A ...

  8. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Water purification (12) 1330 (GA). Water structure (12) 1307 (GA). Weak interactions (9) 802 (GA). Weierstrass approximation (4) 341 (GA). What is Science? (9) 860 (RF). Why the Universe is Expanding (5) 480 (CL). Wiles (10) 950 (SA). Wiesel Torsten (1) 88 (FF). Woodward–Hoffmann rules (12) 1211 (GA). World War I (7) ...

  9. SUBJECT INDEX

    Indian Academy of Sciences (India)

    M. Senthilkumar (Newgen Imaging) 1461 1996 Oct 15 13:05:22

    Ocean-atmosphere interaction and synoptic weather conditions in association with the two contrasting phases of monsoon during BOBMEX-1999. 283. Baseline lengths. Pre-seismic, co-seismic and post-seismic displace- ments associated with the Bhuj 2001 earthquake derived from recent and historic geodetic data 331.

  10. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Unknown

    Macrocyclic effects upon isomeric CuIIMII and MIICuII cores. Formation with unsymme- tric phenol-based macrocyclic ligands 291. Corrosion inhibition. Effect of piperidones on hydrogen permeation and corrosion inhibition of mild steel in acidic solutions. 127. Crosslinked oxalates. Inorganic-organic hybrid framework solids.

  11. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Vindhyan basin, India. 61. Blind fault. 2-D deformation of two welded half-spaces due to a blind dip-slip fault. 277. Calibration. Modeling of groundwater flow for Mujib aquifer,. Jordan ... Marine boundary layer characteristics during a cyclonic storm over the .... India, under different synoptic flow situations 557. Meteoric water.

  12. SUBJECT INDEX

    Indian Academy of Sciences (India)

    Unknown

    bdenum(IV) and tungsten(IV) with N- alkylphenothiazines and their interactions with L-cysteine and L-histidine. 165. Allyl and benzyl ethers. A convenient procedure for the synthesis of allyl and benzyl ethers from alcohols and phenols. 191. Ambient temperature. New mesogenic homologous series of α- methylcinnamates.

  13. SUBJECT INDEX

    Indian Academy of Sciences (India)

    R.Narasimhan(krishtel emaging)1461 1996 Oct 15 13:05:22

    accumulation rates. Records of climatic changes and volcanic events in an ice core from Central Dronning Maud Land (East. Antarctica) during the past century. 39. ADEOS-I. Variability of photosynthetic pigments in the Colom- bian Pacific Ocean and its relationship with the wind field using ADEOS-I data. 227. Adriatic Sea.

  14. SUBJECT INDEX

    Indian Academy of Sciences (India)

    flow deposit in Miocene-sediments of Andaman-Java subduction complex. 19. Antarctica. Influence of climatic teleconnections on the temporal isotopic variability as recorded in a firn core from the coastal Dronning Maud Land, East Antarctica. 41. Apatite fission track (AFT). Detrital zircon and apatite fission track data in the.

  15. SUBJECT INDEX

    Indian Academy of Sciences (India)

    in the Deccan Volcanic Province. 505. Ascent trajectory. Launch strategy for Indian lunar mission and precision injection to the Moon using genetic algorithm. 711 ... Space operation system for Chang'E program and its capability evaluation. 795. Chang'E-1. Scientific objectives and payloads of Chang'E-1 lunar satellite.

  16. Bibliography, subject index, and author index of the literature examined by the Radiation Shielding Information Center. Volume 7

    Energy Technology Data Exchange (ETDEWEB)

    Trubey, D.K.; Roussin, R.W.; Gustin, A.B.

    1983-08-01

    An indexed bibliography of open literature selected by the Radiation Shielding Information Center since the previous volume was published in 1980 is presented in the area of radiation transport and shielding against radiation from nuclear reactors (fission and fusion), x-ray machines, radioisotopes, nuclear weapons (including fallout, and low energy accelerators (e.g., neutron generators). The bibliography was typeset from computer files constituting the RSIC Storage and Retrieval Information System. In addition to lists of literature titles by subject categories (accessions 6201-10156), an author index is given. Most of the literature selected for Volume VII was published in the years 1977 to 1981.

  17. Lp(a) (Lipoprotein(a)) Levels Predict Progression of Carotid Atherosclerosis in Subjects With Atherosclerotic Cardiovascular Disease on Intensive Lipid Therapy: An Analysis of the AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes) Carotid Magnetic Resonance Imaging Substudy.

    Science.gov (United States)

    Hippe, Daniel S; Phan, Binh An P; Sun, Jie; Isquith, Daniel A; O'Brien, Kevin; Crouse, John R; Anderson, Todd; Huston, John; Marcovina, Santica M; Hatsukami, Thomas S; Yuan, Chun; Zhao, Xue-Qiao

    2018-01-04

    To assess whether Lp(a) (lipoprotein(a)) levels and other lipid levels were predictive of progression of atherosclerosis burden as assessed by carotid magnetic resonance imaging in subjects who have been treated with LDL-C (low-density lipoprotein cholesterol)-lowering therapy and participated in the AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes). AIM-HIGH was a randomized, double-blind study of subjects with established vascular disease, elevated triglycerides, and low HDL-C (high-density lipoprotein cholesterol). One hundred fifty-two AIM-HIGH subjects underwent both baseline and 2-year follow-up carotid artery magnetic resonance imaging. Plaque burden was measured by the percent wall volume (%WV) of the carotid artery. Associations between annualized change in %WV with baseline and on-study (1 year) lipid variables were evaluated using multivariate linear regression. P values were adjusted for multiple comparisons. Average %WV at baseline was 41.6±6.8% and annualized change in %WV over 2 years ranged from -3.2% to 3.7% per year (mean: 0.2±1.1% per year; P=0.032). Increases in %WV were significantly associated with higher baseline Lp(a) (β=0.34 per 1-SD increase of Lp(a); 95% CI, 0.15-0.52; P<0.001) after adjusting for clinical risk factors and other lipid levels. On-study Lp(a) had a similar positive association with %WV progression (β=0.33; 95% CI, 0.15-0.52; P<0.001). Despite intensive lipid therapy, aimed at aggressively lowering LDL-C to <70 mg/dL, carotid atherosclerosis continued to progress as assessed by carotid magnetic resonance imaging and that elevated Lp(a) levels were independent predictors of increases in atherosclerosis burden. © 2018 American Heart Association, Inc.

  18. Equalizer Complexity for 6-LP Mode 112 Gbit/s m-ary DP-QAM Space Division Multiplexed Transmission in Strongly Coupled Few-Mode-Fibers

    DEFF Research Database (Denmark)

    Asif, Rameez; Ye, Feihong; Morioka, Toshio

    2015-01-01

    We have quantified equalizer complexity for transmitting dual-polarized 6-LP modes (LP01, LP11a, LP11b, LP21a, LP21b and LP02) of 112 Gbit/s m-ary QAM (m=4, 16, 32, 64, 256) single carrier signals over 20 km step-index few-mode fiber. The transmitted signals are strongly coupled and recovered using...... 12×12 multiple-input multiple-output (MIMO) adaptive digital signal processing (DSP). Time domain equalization (TDE) is realized to implement the linear adaptive MIMO module that is implemented in blind mode using conventional constant-modulusalgorithm (CMA) for finite impulse response (FIR) adaptive...

  19. Determinants of the ambulatory arterial stiffness index in 7604 subjects from 6 populations

    DEFF Research Database (Denmark)

    Adiyaman, Ahmet; Dechering, Dirk G; Boggia, José

    2008-01-01

    The ambulatory arterial stiffness index (AASI) is derived from 24-hour ambulatory blood pressure recordings. We investigated whether the goodness-of-fit of the AASI regression line in individual subjects (r(2)) impacts on the association of AASI with established determinants of the relation betwe...

  20. Assessment of periodontal status among dental fluorosis subjects using community periodontal index of treatment needs.

    Science.gov (United States)

    Kumar, Pradeep R; John, Joseph

    2011-01-01

    To determine the periodontal status and treatment needs among dental fluorosis subjects residing in Ennore, Chennai, using Community Periodontal Index of Treatment Needs (CPITN). All the subjects with dental fluorosis above 15 years of age, permanent residents of Ennore, were included in the study. Subjects with known systemic diseases and subjects with other intrinsic dental stains were excluded from the study. Periodontal status was estimated using CPITN and Dental fluorosis was recorded using Dean's Dental Fluorosis Index. The total number of study subjects was 1075, of which 489 were males and 586 were females. Males were predominantly affected with periodontal disease than females. This was found to be statistically significant (P=0.000). The association between Degree of Fluorosis and Periodontal Status is statistically significant (P=0.000). There was statistically significant difference in mean number of sextants between the degree of fluorosis in each of the periodontal status (P=0.000). The finding that the lower prevalence of shallow pockets in the study area, where the fluoride level in the drinking water ranges from 1.83 to 2.01 ppm, indicates that the use of fluoride in water is beneficial to the periodontal tissues.

  1. The Subjective Wellbeing of High-School Students: Validating the Personal Wellbeing Index-School Children

    Science.gov (United States)

    Tomyn, Adrian J.; Cummins, Robert A.

    2011-01-01

    The Personal Wellbeing Index-School Children (PWI-SC) is designed as a parallel form of the adult PWI-A, to measure subjective wellbeing. This study examines the psychometric properties of the PWI-SC. Data from 351 students, aged between 12 and 20 years, were collected by two independent studies over the years 2005-2006. Using the combined data,…

  2. Arterial stiffness evaluation by cardio-ankle vascular index in hypertension and diabetes mellitus subjects.

    Science.gov (United States)

    Wang, Hongyu; Liu, Jinbo; Zhao, Hongwei; Fu, Xiaobao; Shang, Guangyun; Zhou, Yingyan; Yu, Xiaolan; Zhao, Xujing; Wang, Guang; Shi, Hongyan

    2013-01-01

    Arterial stiffness is an independent predictor for vascular diseases. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. In the present study, we investigated the possible risk factors involving CAVI in hypertension and diabetes mellitus (DM) subjects. One thousand sixty-three subjects (M/F 533/530) from Shougang Corporation Examination Center were divided into four groups: healthy group (n = 639); hypertension group (n = 312); DM group (n = 58); and hypertension with DM group (n = 54). CAVI was measured by VS-1000 apparatus. Our results showed that CAVI was significantly higher in hypertension subjects with DM than in healthy and hypertension group, respectively (8.59 ± 1.08 vs 7.23 ± 1.10; 8.59 ± 1.08 vs 7.94 ± 1.33; both P hypertension subjects with DM compared with healthy and hypertension groups. Copyright © 2013 American Society of Hypertension. Published by Elsevier Inc. All rights reserved.

  3. High hydrostatic pressure processing reduces the glycemic index of fresh mango puree in healthy subjects.

    Science.gov (United States)

    Elizondo-Montemayor, Leticia; Hernández-Brenes, Carmen; Ramos-Parra, Perla A; Moreno-Sánchez, Diana; Nieblas, Bianca; Rosas-Pérez, Aratza M; Lamadrid-Zertuche, Ana C

    2015-04-01

    Dietary guidelines recommend the daily consumption of fruits; however, healthy and type 2 diabetes mellitus (T2DM) subjects receive conflicting messages regarding ingestion of fruits, such as mango, because of its sugar content. We investigated the effects of high hydrostatic pressure (HHP) processing of fresh mango puree (MP) on the glycemic indexes (GIs) and postprandial glycemic responses of 38 healthy Mexican subjects in a randomized cross-over clinical trial. Physicochemical characterization of MP included sugar profiles by HPLC-ELSD, starch, fibers, moisture, viscosity, swelling capacity and solubility properties of alcohol insoluble residue (AIR). The mean GI for HHP-MP was significantly lower (32.7 ± 13.4) than that of unprocessed-MP (42.7 ± 19.5). A significantly higher proportion of subjects showed a low GI following the consumption of HHP-MP compared to unprocessed-MP and none of them showed a high GI for the HHP-MP, compared to a significantly higher proportion for the unprocessed-MP. The viscosity and AIR solubility values of HHP-MP samples were significantly higher, which influenced glucose peaking later (Tmax) at 45 minutes and induced 20% lower AUC values than unprocessed-MP, corresponding to greater retardation indexes. The study findings support data stating that low GI fruits are appropriate for glycemic control and that mango may be included as part of healthy subjects' diets and potentially T2DM subjects' diets. Furthermore, HHP processing of mango may offer additional benefits for glycemic control, as its performance regarding GI, AUC and Tmax was significantly better than that of the unprocessed-MP. To our knowledge, this is the first report on the impact of this commercial non-thermal pasteurization technology on glucose metabolism.

  4. Glycemic index of grain amaranth, wheat and rice in NIDDM subjects.

    Science.gov (United States)

    Chaturvedi, A; Sarojini, G; Nirmala, G; Nirmalamma, N; Satyanarayana, D

    1997-01-01

    Glycemic index of grain amaranth, wheat and rice preparations was studied in non-insulin dependent diabetic subjects. Diets containing 50 g carbohydrate equivalent were given and post-prandial blood glucose estimated at different intervals. Glycemic index calculated for different experimental diets showed that GI of amaranth-wheat composite flour diet (25:75) was the least (65.6%) followed by wheat diet (65.7%), rice diet (69.2%), amaranth-wheat flour 50:50 (75.5%), and popped amaranth in milk (97.3%). Therefore 25:75 combination of amaranth and wheat, wheat and rice can be considered low GI food, 50:50 grain amaranth and wheat medium GI food and popped amaranth and milk combination high GI food.

  5. Online lektiehjælp

    DEFF Research Database (Denmark)

    Hansen, Jens Jørgen; Remvig, Kirstin

    2016-01-01

    vejledningsdidaktik, herunder metoder, modeller og materialer for lektievejledning i regi af Lektier Online. Lektier Online er en organisation ved Statsbiblioteket i Århus, der tilbyder en online lektiecafe, hvor bl.a. gymnasie-elever kan få hjælp af frivillige universitetsstuderende. Dette didaktiske de-sign er et...

  6. Comparative study of cardio-ankle vascular index between Chinese and Japanese healthy subjects.

    Science.gov (United States)

    Wang, Hongyu; Shirai, Kohji; Liu, Jinbo; Lu, Na; Wang, Min; Zhao, Hongwei; Xie, Jun; Yu, Xiaolan; Fu, Xiaobao; Shi, Hongyan; Li, Lihong

    2014-01-01

    Arterial stiffness is an independent predictor for vascular diseases. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. However, there was little research about the CAVI value between different countries. The aim of the present study was to compare CAVI between Chinese and Japanese subjects and to assess related factors. 2519 healthy persons [1245 Chinese (M/F, 524/721) and 1274 Japanese (M/F, 534/740)] from the Department of Physical Examination were enrolled into our study. CAVI was recorded using a VaseraVS-1000 vascular screening system. CAVI was increasing with aging in all subjects. CAVI was significantly lower in Chinese compared with Japanese both in male and female. There was difference in lipid metabolism between these two groups. Multivariate analysis showed that age, systolic blood pressure (SBP), fasting plasma glucose (FPG), plasma creatinine (Cr) were significant independent associating factors of CAVI in Chinese persons (β = 0.548, p < 0.001; β = 0.129, p = 0.001; β = 0.105, p = 0.006; and β = 0.100, p = 0.012, respectively), whereas age, SBP, high-density lipoprotein cholesterol (HDL-C), Cr, body mass index (BMI), FPG were significant independent associating factors of CAVI in Japanese subjects (β = 0.669, p < 0.001; β = 0.198, p < 0.001; β = -0.079, p < 0.001; β = 0.090, p < 0.001; β = -0.124, p < 0.001; β = 0.055, p=0.009; respectively). CAVI was increasing with aging in both Chinese and Japanese subjects. CAVI was significantly lower in Chinese than in Japanese subjects. Age, SBP, FPG and creatinine were independently associated with CAVI in both Chinese and Japanese subjects.

  7. Genetic variation in the NOC gene is associated with body mass index in Chinese subjects.

    Science.gov (United States)

    Chang, Yi-Cheng; Chiu, Yen-Feng; Liu, Pi-Hua; Hee, Siow Wei; Chang, Tien-Jyun; Jiang, Yi-Der; Lee, Wei-Jei; Lee, Po-Chu; Kao, Hui-Yi; Hwang, Juey-Jen; Chuang, Lee-Ming

    2013-01-01

    Circadian clock genes are critical regulators of energy homeostasis and metabolism. However, whether variation in the circadian genes is associated with metabolic phenotypes in humans remains to be explored. In this study, we systemically genotyped 20 tag single nucleotide polymorphisms (SNPs) in 8 candidate genes involved in circadian clock, including CLOCK, BMAL1(ARNTL), PER1, PER2, CRY1, CRY2, CSNK1E,, and NOC(CCRN4L) in 1,510 non-diabetic Chinese subjects in Taipei and Yunlin populations in Taiwan. Their associations with metabolic phenotypes were analyzed. We found that genetic variation in the NOC gene, rs9684900 was associated with body mass index (BMI) (P = 0.0016, Bonferroni corrected P = 0.032). Another variant, rs135764 in the CSNK1E gene was associated with fasting glucose (P = 0.0023, Bonferroni corrected P = 0.046). These associations were consistent in both Taipei and Yunlin populations. Significant epistatic and joint effects between SNPs on BMI and related phenotypes were observed. Furthermore, NOC mRNA levels in human abdominal adipose tissue were significantly increased in obese subjects compared to non-obese controls. Genetic variation in the NOC gene is associated with BMI in Chinese subjects.

  8. Fasting Ghrelin Levels Are Decreased in Obese Subjects and Are Significantly Related With Insulin Resistance and Body Mass Index

    Directory of Open Access Journals (Sweden)

    Dimitrios Papandreou

    2017-10-01

    CONCLUSION: Obese subjects have low fasting ghrelin levels that they are significantly related to insulin resistance and body mass index. More prospective studies are needed to establish the role of ghrelin in the pathogenesis of human obesity.

  9. Usage and Impact of Controlled Vocabularies in a Subject Repository for Indexing and Retrieval

    Directory of Open Access Journals (Sweden)

    Timo Borst

    2012-04-01

    Full Text Available Since 2009, the German National Library for Economics (ZBW supports both indexing and retrieval of Open Access scientific publications like working papers, postprint articles and conference papers by means of a terminology web service. This web service is based on concepts organized as a ‘Standard Thesaurus for Economics’ (STW, which is modelled and regularly published as Linked Open Data. Moreover, it is integrated into the institution’s subject repository for automatically suggesting appropriate key words while indexing and retrieving documents, and for automatically expanding search queries on demand to gain better search results. While this approach looks promising to augment ‘off the shelf’ repository software systems in a lightweight manner with a disciplinary profile, there is still significant uncertainty about the effective usage and impact of controlled terms in the realm of these systems. To cope with this, we analyze the repository’s logfiles to get evidence of search behaviour which is potentially influenced by auto suggestion and expansion of scientific terms derived from a discipline’s literature.

  10. Obesity indexes and total mortality among elderly subjects at high cardiovascular risk: the PREDIMED study.

    Directory of Open Access Journals (Sweden)

    Miguel A Martínez-González

    Full Text Available Different indexes of regional adiposity have been proposed for identifying persons at higher risk of death. Studies specifically assessing these indexes in large cohorts are scarce. It would also be interesting to know whether a dietary intervention may counterbalance the adverse effects of adiposity on mortality.We assessed the association of four different anthropometric indexes (waist-to-height ratio (WHtR, waist circumference (WC, body mass index (BMI and height with all-cause mortality in 7447 participants at high cardiovascular risk from the PREDIMED trial. Forty three percent of them were men (55 to 80 years and 57% were women (60 to 80 years. All of them were initially free of cardiovascular disease. The recruitment took place in 11 recruiting centers between 2003 and 2009.After adjusting for age, sex, smoking, diabetes, hypertension, intervention group, family history of coronary heart disease, and leisure-time physical activity, WC and WHtR were found to be directly associated with a higher mortality after 4.8 years median follow-up. The multivariable-adjusted HRs for mortality of WHtR (cut-off points: 0.60, 0.65, 0.70 were 1.02 (0.78-1.34, 1.30 (0.97-1.75 and 1.55 (1.06-2.26. When we used WC (cut-off points: 100, 105 and 110 cm, the multivariable adjusted Hazard Ratios (HRs for mortality were 1.18 (0.88-1.59, 1.02 (0.74-1.41 and 1.57 (1.19-2.08. In all analyses, BMI exhibited weaker associations with mortality than WC or WHtR. The direct association between WHtR and overall mortality was consistent within each of the three intervention arms of the trial.Our study adds further support to a stronger association of abdominal obesity than BMI with total mortality among elderly subjects at high risk of cardiovascular disease. We did not find evidence to support that the PREDIMED intervention was able to counterbalance the harmful effects of increased adiposity on total mortality.Controlled-Trials.com ISRCTN35739639.

  11. Obesity Indexes and Total Mortality among Elderly Subjects at High Cardiovascular Risk: The PREDIMED Study

    Science.gov (United States)

    Martínez-González, Miguel A.; García-Arellano, Ana; Toledo, Estefanía; Bes-Rastrollo, Maira; Bulló, Mónica; Corella, Dolores; Fito, Montserrat; Ros, Emilio; Lamuela-Raventós, Rosa Maria; Rekondo, Javier; Gómez-Gracia, Enrique; Fiol, Miquel; Santos-Lozano, Jose Manuel; Serra-Majem, Lluis; Martínez, J. Alfredo; Eguaras, Sonia; Sáez-Tormo, Guillermo; Pintó, Xavier; Estruch, Ramon

    2014-01-01

    Background Different indexes of regional adiposity have been proposed for identifying persons at higher risk of death. Studies specifically assessing these indexes in large cohorts are scarce. It would also be interesting to know whether a dietary intervention may counterbalance the adverse effects of adiposity on mortality. Methods We assessed the association of four different anthropometric indexes (waist-to-height ratio (WHtR), waist circumference (WC), body mass index (BMI) and height) with all-cause mortality in 7447 participants at high cardiovascular risk from the PREDIMED trial. Forty three percent of them were men (55 to 80 years) and 57% were women (60 to 80 years). All of them were initially free of cardiovascular disease. The recruitment took place in 11 recruiting centers between 2003 and 2009. Results After adjusting for age, sex, smoking, diabetes, hypertension, intervention group, family history of coronary heart disease, and leisure-time physical activity, WC and WHtR were found to be directly associated with a higher mortality after 4.8 years median follow-up. The multivariable-adjusted HRs for mortality of WHtR (cut-off points: 0.60, 0.65, 0.70) were 1.02 (0.78–1.34), 1.30 (0.97–1.75) and 1.55 (1.06–2.26). When we used WC (cut-off points: 100, 105 and 110 cm), the multivariable adjusted Hazard Ratios (HRs) for mortality were 1.18 (0.88–1.59), 1.02 (0.74–1.41) and 1.57 (1.19–2.08). In all analyses, BMI exhibited weaker associations with mortality than WC or WHtR. The direct association between WHtR and overall mortality was consistent within each of the three intervention arms of the trial. Conclusions Our study adds further support to a stronger association of abdominal obesity than BMI with total mortality among elderly subjects at high risk of cardiovascular disease. We did not find evidence to support that the PREDIMED intervention was able to counterbalance the harmful effects of increased adiposity on total mortality. Trial

  12. Large-scale international validation of the ADO index in subjects with COPD: an individual subject data analysis of 10 cohorts

    Science.gov (United States)

    Puhan, Milo A; Hansel, Nadia N; Sobradillo, Patricia; Enright, Paul; Lange, Peter; Hickson, DeMarc; Menezes, Ana M; ter Riet, Gerben; Held, Ulrike; Domingo-Salvany, Antonia; Mosenifar, Zab; Antó, Josep M; Moons, Karel G M; Kessels, Alphons; Garcia-Aymerich, Judith

    2012-01-01

    Background Little evidence on the validity of simple and widely applicable tools to predict mortality in patients with chronic obstructive pulmonary disease (COPD) exists. Objective To conduct a large international study to validate the ADO index that uses age, dyspnoea and FEV1 to predict 3-year mortality and to update it in order to make prediction of mortality in COPD patients as generalisable as possible. Design Individual subject data analysis of 10 European and American cohorts (n=13 914). Setting Population-based, primary, secondary and tertiary care. Patients COPD GOLD stages I–IV. Measurements We validated the original ADO index. We then obtained an updated ADO index in half of our cohorts to improve its predictive accuracy, which in turn was validated comprehensively in the remaining cohorts using discrimination, calibration and decision curve analysis and a number of sensitivity analyses. Results 1350 (9.7%) of all subjects with COPD (60% male, mean age 61 years, mean FEV1 66% predicted) had died at 3 years. The original ADO index showed high discrimination but poor calibration (p<0.001 for difference between predicted and observed risk). The updated ADO index (scores from 0 to 14) preserved excellent discrimination (area under curve 0.81, 95% CI 0.80 to 0.82) but showed much improved calibration with predicted 3-year risks from 0.7% (95% CI 0.6% to 0.9%, score of 0) to 64.5% (61.2% to 67.7%, score of 14). The ADO index showed higher net benefit in subjects at low-to-moderate risk of 3-year mortality than FEV1 alone. Interpretation The updated 15-point ADO index accurately predicts 3-year mortality across the COPD severity spectrum and can be used to inform patients about their prognosis, clinical trial study design or benefit harm assessment of medical interventions. PMID:23242246

  13. Exercise training decreases body mass index in subjects aged 50 years and over

    Directory of Open Access Journals (Sweden)

    Ignatio Rika Haryono

    2010-12-01

    Full Text Available Exercise training can improve blood pressure in normotensive, prehypertensive, and hypertensive subjects. One of the mechanisms of blood pressure reduction in hypertensive patients with obesity is through weight loss. This study aimed to examine the effect of exercise training on bodyweight and the relationship between weight loss and reduction of blood pressure. An experimental pre-post test design without controls was used to evaluate the effect of exercise training on weight loss. The study involved 89 elderly aged 50 years or more, consisting of 40 men and 49 women, who were members of Senayan Sport Fitness Club and had been exercising for at least three months. Exercise training was programmed and performed three times a week, consisting of aerobic (walking, jogging, static cycling, and resistance exercise. All exercise was performed for one to two hours with mild to moderate intensity. Blood pressure and body weight were obtained from medical records. Paired t-test showed that systolic blood pressure (SBP, diastolic blood pressure (DBP, mean arterial pressure (MAP, pulse pressure (PP, and body mass index (BMI were significantly lower after training [(systolic, 126.3 ± 2.9 vs 122.3 ± 2.7, p=0.02, (diastolic, 80.2 ± 3.1 vs 77.2 ± 2.4, p=0.00, (MAP, 95.6 ± 4.6 vs 92.2 ± 3.4, p=0.00, (PP, 46.1 ± 4.2 vs 45.1 ± 3.6, p=0.04, (BMI, 24.5 ± 2.9 vs 23.6 ± 2.9, p=0.04]. Duration of training was the most influential factor affecting rBMI, (Beta = 0.38; p=0.00. Exercise training could lower BMI and the reduction in diastolic blood pressure was higher for the subjects aged 70 years and over.

  14. Exercise training decreases body mass index in subjects aged 50 years and over

    Directory of Open Access Journals (Sweden)

    Ignatio Rika Haryono

    2016-02-01

    Full Text Available Exercise training can improve blood pressure in normotensive, prehypertensive, and hypertensive subjects. One of the mechanisms of blood pressure reduction in hypertensive patients with obesity is through weight loss. This study aimed to examine the effect of exercise training on bodyweight and the relationship between weight loss and reduction of blood pressure. An experimental pre-post test design without controls was used to evaluate the effect of exercise training on weight loss. The study involved 89 elderly aged 50 years or more, consisting of 40 men and 49 women, who were members of Senayan Sport Fitness Club and had been exercising for at least three months. Exercise training was programmed and performed three times a week, consisting of aerobic (walking, jogging, static cycling, and resistance exercise. All exercise was performed for one to two hours with mild to moderate intensity. Blood pressure and body weight were obtained from medical records. Paired t-test showed that systolic blood pressure (SBP, diastolic blood pressure (DBP, mean arterial pressure (MAP, pulse pressure (PP, and body mass index (BMI were significantly lower after training [(systolic, 126.3 ± 2.9 vs 122.3 ± 2.7, p=0.02, (diastolic, 80.2 ± 3.1 vs 77.2 ± 2.4, p=0.00, (MAP, 95.6 ± 4.6 vs 92.2 ± 3.4, p=0.00, (PP, 46.1 ± 4.2 vs 45.1 ± 3.6, p=0.04, (BMI, 24.5 ± 2.9 vs 23.6 ± 2.9, p=0.04]. Duration of training was the most influential factor affecting rBMI, (Beta = 0.38; p=0.00. Exercise training could lower BMI and the reduction in diastolic blood pressure was higher for the subjects aged 70 years and over.

  15. [Comparative analysis of the glycemic response and glycemic index of instant mashed potatoes in subjects undergoing laparoscopic sleeve gastrectomy and control subjects].

    Science.gov (United States)

    Fuentes Valdes, Gabriel; del Valle Flores, Miguel; Vega Soto, Claudia

    2014-12-01

    The laparoscopic sleeve gastrectomy (LSG) is a successful surgical procedure for morbid obesity. However, post surgery weight regain is usual, thus applying the glycemic index could promote good weight control. To compare the glycemic index (GI) and glycemic response (GR) obtained of instant mashed potatoes in individuals subjected to LSG versus control subjects. GI and GR were assessed in 10 LSG subjects and compared with 10 controls. GI methodology proposed by FAO/WHO was used; instant mashed potatoes as test food and white bread as standard food (50g available CHO). Capillary blood sample 0 (fasting), 30, 60, 90 and 120 minutes. The GI was determined by trapezoidal method. ANOVA was used to compare a factor between RG and IG groups; t-student to compare RG between foods. Statistical significance pglycemic responses in LSG group, and its consumption possibly favoring weight regain. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  16. The Subjective Index for Physical and Social Outcome (SIPSO in Stroke: investigation of its subscale structure

    Directory of Open Access Journals (Sweden)

    George Steve

    2010-04-01

    Full Text Available Abstract Background Short and valid measures of the impact of a stroke on integration are required in health and social settings. The Subjective Index of Physical and Social Outcome (SIPSO is one such measure. However, there are questions whether scores can be summed into a total score or whether subscale scores should be calculated. This paper aims to provide clarity on the internal construct validity of the subscales and the total scale. Methods SIPSO data were collected as part of two parallel surveys of the met and unmet needs of 445 younger people (aged 18-65 with non-recent stroke (at least one year and living at home. Factor, Mokken and Rasch analysis were used. Results Factor analysis supported a two factor structure (explaining 68% of the variance as did the Mokken analysis (overall Loevinger coefficient 0.77 for the Physical Integration subscale; 0.51 for the Social Integration subscale. Both subscales fitted the Rasch model (P > 0.01 after adjusting for some observed differential item functioning. The 10-items together did not fit the Rasch model. Conclusions The SIPSO subscales are valid for use with stroke patients of working age but the total SIPSO is not. The conversion table can be used by clinicians and researchers to convert ordinal data to interval level prior to mathematical operations and other parametric procedures. Further work is required to explore the occurrence of bias by gender for some of the items.

  17. Soil properties and perceived disturbance of grasslands subjected to mechanized military training: Evaluation of an index

    Science.gov (United States)

    Althoff, Donald P.; Althoff, P.S.; Lambrecht, N.D.; Gipson, P.S.; Pontius, J.S.; Woodford, P.B.

    2007-01-01

    Mechanized maneuver training impacts the landscape by creating depressions, compacting soils, producing bare ground areas, transporting seeds of invasive plants, and crushing vegetation. We measured 3 physical, 13 chemical, and 2 biological soil properties and used a disturbance index (DI) based on perceptions of soil conditions on a military installation to assess the condition of 100 ?? 100 m plots (1 ha): 10 in 2002 and 10 in 2004. Potential DI scores range from 0 (no appreciable evidence of disturbance) to 1 (>95 per cent of the plot disturbed). Bulk density, porosity (%), and water content (%) - all at 5-1-10-0cm depth, and nematode family richness (NFR) were significantly, negatively correlated (Spearman coefficients, rs) with the DI of both years. The strong negative correlation (rs., = -0.69 in 2002, -0.79 in 2004) of NFR with the DI appears to reflect the status of nematode diversity and, therefore, may serve as a useful, inexpensive approach to rapidly assessing grasslands subjected to mechanized military training. Copyright ?? 2007 John Wiley & Sons, Ltd.

  18. Subjectivity

    Directory of Open Access Journals (Sweden)

    Jesús Vega Encabo

    2015-11-01

    Full Text Available In this paper, I claim that subjectivity is a way of being that is constituted through a set of practices in which the self is subject to the dangers of fictionalizing and plotting her life and self-image. I examine some ways of becoming subject through narratives and through theatrical performance before others. Through these practices, a real and active subjectivity is revealed, capable of self-knowledge and self-transformation. 

  19. Bibliography, subject index, and author index of the literature examined by the Radiation Shielding Information Center (Reactor and Weapons Radiation Shielding). [1973--1976

    Energy Technology Data Exchange (ETDEWEB)

    1978-01-01

    An indexed bibliography is presented of literature selected by the Radiation Shielding Information Center since the previous volume was published in 1974 in the area of radiation transport and shielding against radiation from nuclear reactors, x-ray machines, radioisotopes, nuclear weapons (including fallout), and low-energy accelerators (e.g., neutron generators). In addition to lists of literature titles by subject categories (accessions 3501-4950), author and keyword indexes are given. Most of the literature selected for Vol. V was published in the years 1973 to 1976.

  20. Bibliography, subject index, and author index of the literature examined by the radiation shielding information center. Volume 6. Reactor and weapons radiation shielding

    Energy Technology Data Exchange (ETDEWEB)

    1980-05-01

    An indexed bibliography is presented of literature selected by the Radiation Shielding Information Center since the previous volume was published in 1978 in the area of radiation transport and shielding against radiation from nuclear reactors, x-ray machines, radioisotopes, nuclear weapons (including fallout), and low energy accelerators (e.g., neutron generators). The bibliography was typeset from data processed by computer from magnetic tape files. In addition to lists of literature titles by subject categories (accessions 4951-6200), an author index is given.

  1. The relation between Lp-PLA2 levels with periodic limb movements.

    Science.gov (United States)

    Bekci, Taha Tahir; Kayrak, Mehmet; Kiyici, Aysel; Ari, Hatem; Teke, Turgut; Maden, Emin; Akilli, Hakan

    2012-03-01

    Lipoprotein-associated phospholipase A2 (Lp-PLA2), a novel marker of vulnerable plaque to prone rupture, is a predictor of both cardiovascular event and cerebrovascular event, and highly sensitive-C-reactive protein (hs-CRP) is an acute-phase response protein implicated in a broad range of cardiovascular diseases. We aimed to examine the association between periodic limb movements in sleep (PLMs) with circulating Lp-PLA2 and hs-CRP levels in patients with PLMs. Seventy patients with newly diagnosed PLM with polysomnography were enrolled this study. Patients were divided into two groups according to PLM index (normal PLM index, PLM index, ≥15). Lp-PLA2 and hs-CRP concentrations were measured in serum samples by turbidimetric and nephelometric methods, respectively. The concentrations of these parameters were compared between two groups and correlation analysis was performed between PLMs and Lp-PLA2 and hs-CRP levels. Lp-PLA2 levels and hs-CRP were significantly increased in elevated PLM index group compared with the control group (206.8 ± 78.1 vs 157.8 ± 56.7, p = 0.003, and 4.2 ± 3.5 vs 2.4 ± 2.1, p = 0.02, respectively). PLM index was positively correlated with Lp-PLA2 levels (r = 0.40, p = 0.001) and hs-CRP (r = 0.24, p = 0.05). In the linear regression model, Lp-PLA2 was an independent predictor of PLM index (R(2) = 0.36, p = 0.005). This study demonstrated an independent linear relation between PLM index and Lp-PLA2. In addition, it was seen increased Lp-PLA2 and hs-CRP levels in patients with elevated PLM index. Based on these results, we can suggest that risk of vascular events may be increased in patients with PLMs and with increased PLM index.

  2. Glycemic response to carob (ceratonia siliqua L) in healthy subjects and with the in vitro hydrolysis index.

    Science.gov (United States)

    Milek Dos Santos, Luciana; Tomzack Tulio, Lindamir; Fuganti Campos, Leticia; Ramos Dorneles, Marcelo; Carneiro Hecke Krüger, Claudia

    2014-09-12

    The purpose of this study was to determine the in vivo glycemic index of carob tablets with healthy subjects and to determine the in vitro glycemic index of carob tablets and carob flour by the hydrolysis index. Seven healthy volunteers consumed portions of carob tablets containing 26g of available carbohydrate. Their capillary blood was taken at intervals after carob or glucose consumption. The glycemic hydrolysis index by an in vitro technique was based in the release of glucose after enzymatic treatment of carob tablets and carob flour. The determination of the fiber content was performed using the enzymatic- gravimetric method. By the in vivo determination, the estimated glycemic index of carob tablets could be considered low (≤ 55). By the in vitro determination, the estimated glycemic index ranged from 40.1+0.02 of carob tablets to 40.6+0.05 of carob flour. The total fiber values obtained for carob flour samples were from 42.6% ± 0.49 to 42.9% ± 0.68 with no statistical significant differences between samples. Carob tablets and carob flour could be classified as low glycemic index food and low glycemic load food. Carob flour is a high fiber food, containing mainly high levels of insoluble fiber. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  3. Effects of dietary fiber and low glycemic index diet on glucose control in subjects with type 2 diabetes mellitus.

    Science.gov (United States)

    Bajorek, Sarah A; Morello, Candis M

    2010-11-01

    To review the effects of dietary fiber and a low glycemic index diet on glycemic risk factors in people with type 2 diabetes mellitus (T2DM) or T2DM and dyslipidemia. Literature search was conducted using PubMed, Cochrane Library, The Natural Standard, and The Natural Medicines through July 2010 using the terms type 2 diabetes mellitus, dietary fiber, psyllium, and glycemic index. Articles included were randomized controlled studies or meta-analyses examining the effects of dietary interventions (dietary fiber, low glycemic index diet, or psyllium) on glycemic risk factors (glycosylated hemoglobin A₁(c) [A1C] or postprandial plasma glucose [PPG] concentrations) in subjects with T2DM or T2DM and dyslipidemia. Both psyllium supplementation and low glycemic index diets have been studied as monotherapy in the treatment of T2DM. Seven studies were reviewed (3 randomized crossover studies, 1 randomized parallel study, 3 randomized blinded parallel studies). Individually, psyllium supplementation and a low glycemic index diet improved glycemic risk factors. PPG and A1C decreased with psyllium 10.2 g per day, while A1C decreased with a low glycemic index diet (average glycemic index 59). However, the results for the low glycemic index diet are controversial. One study was underpowered to detect changes in A1C, while another study had psyllium fiber as a confounding variable. Psyllium supplementation might be an additional therapeutic option for people with T2DM who are already receiving diabetes medication and who still experience elevated PPG concentrations. Further well-designed clinical trials and adjustment for confounding variables are needed to determine the role of a low glycemic index diet in the treatment of T2DM.

  4. Indexing it all the subject in the age of documentation, information, and data

    CERN Document Server

    Day, Ronald E

    2014-01-01

    In this book, Ronald Day offers a critical history of the modern tradition of documentation. Focusing on the documentary index (understood as a mode of social positioning), and drawing on the work of the French documentalist Suzanne Briet, Day explores the understanding and uses of indexicality. He examines the transition as indexes went from being explicit professional structures that mediated users and documents to being implicit infrastructural devices used in everyday information and communication acts. Doing so, he also traces three epistemic eras in the representation of individuals and groups, first in the forms of documents, then information, then data. Day investigates five cases from the modern tradition of documentation. He considers the socio-technical instrumentalism of Paul Otlet, "the father of European documentation" (contrasting it to the hermeneutic perspective of Martin Heidegger); the shift from documentation to information science and the accompanying transformation of persons and texts i...

  5. Composite Estimation for Single-Index Models with Responses Subject to Detection Limits

    KAUST Repository

    Tang, Yanlin

    2017-11-03

    We propose a semiparametric estimator for single-index models with censored responses due to detection limits. In the presence of left censoring, the mean function cannot be identified without any parametric distributional assumptions, but the quantile function is still identifiable at upper quantile levels. To avoid parametric distributional assumption, we propose to fit censored quantile regression and combine information across quantile levels to estimate the unknown smooth link function and the index parameter. Under some regularity conditions, we show that the estimated link function achieves the non-parametric optimal convergence rate, and the estimated index parameter is asymptotically normal. The simulation study shows that the proposed estimator is competitive with the omniscient least squares estimator based on the latent uncensored responses for data with normal errors but much more efficient for heavy-tailed data under light and moderate censoring. The practical value of the proposed method is demonstrated through the analysis of a human immunodeficiency virus antibody data set.

  6. Increasing water intake by 2 liters reduces crystallization risk indexes in healthy subjects.

    Science.gov (United States)

    de La Guéronnière, Viviane; Le Bellego, Laurent; Jimenez, Inmaculada Buendia; Dohein, Oriane; Tack, Ivan; Daudon, Michel

    2011-03-01

    The objective of the present study was to evaluate the effects of drinking 2 additional litres of water/day on several urinary risk factors for lithiasis in healthy subjects, through measurement of crystallization risk indices (Tiselius CRI). 48 healthy subjects, aged 25 to 50 were studied for urinary parameters including CRI in the laboratory ward, for 24 hours. After this first period, they were randomized either to a 2L/d additional water intake (treated group) or usual fluid consumption (control group) for a 6 days period, which ended by a second measurement period in the laboratory ward for 24 hours. Total additional water intake was actually 1.3L/d on average in treated subjects, because subjects decreased other usual sources of fluid intake. In 24 hour urine, Tiselius CRI varied differently among treated subjects and controls between the 2 periods; male controls subjects experienced much higher values (above 2 in average in first morning urine sample) in the second period (p = 0.05). Of interest, in a transversal analysis, we observed a positive relation between BMI or waist circumference on the one hand, and with 24 hour urea excretion or osmotic load on the other hand. These results show a beneficial effect of a final 1.3L additional water intake on Tiselius CRI in healthy subjects.

  7. The fatty liver index is associated with increased mortality in subjects referred to coronary angiography

    NARCIS (Netherlands)

    Lerchbaum, E.; Pilz, S.; Grammer, T.B.; Boehm, B.O.; Stojakovic, T.; Obermayer-Pietsch, B.; Marz, W.

    2013-01-01

    Background and aims: Fatty liver index (FLI), a surrogate parameter for nonalcoholic fatty liver disease, is an emerging risk factor for cardiovascular diseases and mortality. We aimed to evaluate whether FLI is associated with all-cause, cardiovascular, and non-cardiovascular mortality as well as

  8. Analysis of relative kinematic index with normalized standing time between subjects with and without recurrent low back pain.

    Science.gov (United States)

    Sung, Paul S; Danial, Pamela

    2017-02-01

    Although subjects with recurrent low back pain (LBP) demonstrate altered postural control, their postural steadiness during one leg standing is unknown. The purpose of this study was to investigate postural steadiness based on relative kinematic index of the lower limbs and trunk with normalized standing time in subjects with recurrent LBP during dominant and non-dominant leg standing. Sixty individuals participated in the study, including 29 subjects in the control group (18 male, 11 female) and 31 subjects with recurrent LBP (21 male, 10 female). The outcome measures included relative kinematic index of the body regions and normalized standing time during the one leg standing test. The relative kinematic index was the ratio between standstill time and successful standing time. The normalized standing time was defined as a ratio between the successful standing time and the requested standing time. The control group demonstrated significantly longer normalized standing time on the dominant (t = -2.57, p = 0.013) and non-dominant (t = -2.78, p = 0.007) legs than the LBP group. The relative kinematic index of the core spine model significantly decreased for the dominant (t = -3.01, p = 0.004) and non-dominant (t = -3.06, p = 0.003) legs in the LBP group. In addition, the kinematic index indicated pelvis and non-dominant shank during dominant leg standing (R 2 = 0.97) in the LBP group. In the control group, the pelvis was significantly correlated with the core spine model during standing on the dominant (R 2 = 0.95) and non-dominant (R 2 = 0.97) legs. The relative kinematic index of the pelvis was found to be most significant for longer standing durations in both groups. In the LBP group, the shank and foot were significantly higher in addition to the pelvis due to possible compensatory motion. The control group took advantage of pelvic control with the core spine to minimize lower limb movements. Clinicians need to consider the core spine for

  9. Comparison of the effects of various types anaerobic trainings in subjects with body mass index values over 25

    OpenAIRE

    Achtarová, Monika

    2015-01-01

    Title: Comparison of the effects of various types anaerobic trainings in subjects with body mass index values over 25 Abstract This thesis describes the mechanisms of anaerobic training, especially focused on high interval training, defines the basic concepts associated with anaerobic activity and focuses on workouts that have excellent benefits for the human body. The core theme of this thesis are HIIT workouts - High Intensity Interval Training, which relate to concepts such as EPOC effect ...

  10. Large-scale international validation of the ADO index in subjects with COPD

    DEFF Research Database (Denmark)

    Puhan, Milo A; Hansel, Nadia N; Sobradillo, Patricia

    2012-01-01

    -year mortality and to update it in order to make prediction of mortality in COPD patients as generalisable as possible. DESIGN: Individual subject data analysis of 10 European and American cohorts (n=13 914). SETTING: Population-based, primary, secondary and tertiary care. PATIENTS: COPD GOLD stages I...

  11. Medical Subject Headings (MeSH) for indexing and retrieving open-source healthcare data.

    Science.gov (United States)

    Marc, David T; Khairat, Saif S

    2014-01-01

    The US federal government initiated the Open Government Directive where federal agencies are required to publish high value datasets so that they are available to the public. Data.gov and the community site Healthdata.gov were initiated to disperse such datasets. However, data searches and retrieval for these sites are keyword driven and severely limited in performance. The purpose of this paper is to address the issue of extracting relevant open-source data by proposing a method of adopting the MeSH framework for indexing and data retrieval. A pilot study was conducted to compare the performance of traditional keywords to MeSH terms for retrieving relevant open-source datasets related to "mortality". The MeSH framework resulted in greater sensitivity with comparable specificity to the keyword search. MeSH showed promise as a method for indexing and retrieving data, yet future research should conduct a larger scale evaluation of the performance of the MeSH framework for retrieving relevant open-source healthcare datasets.

  12. Inverse relationship of cardioankle vascular index with BMI in healthy Japanese subjects: a cross-sectional study.

    Science.gov (United States)

    Nagayama, Daiji; Imamura, Haruki; Sato, Yuta; Yamaguchi, Takashi; Ban, Noriko; Kawana, Hidetoshi; Ohira, Masahiro; Saiki, Atsuhito; Shirai, Kohji; Tatsuno, Ichiro

    2017-01-01

    The objective of this study is to investigate the association of body mass index (BMI) with arterial stiffness assessed by cardioankle vascular index (CAVI). A retrospective cross-sectional study was conducted in 23,257 healthy Japanese subjects (12,729 men and 10,528 women, aged 47.1 ± 12.5 years, BMI 22.9 ± 3.4 kg/m(2)) who underwent health screening between 2004 and 2006 in Japan. Exclusion criteria were current medication use and a past history of cardiovascular disease, hypertension, stroke, diabetes, and nephritis. Male subjects showed significantly higher BMI, CAVI, and triglycerides and lower high-density lipoprotein (HDL)-cholesterol compared with female subjects. Next, the subjects were divided into tertiles of BMI: lower, middle, and upper, in a gender-specific manner. After adjusting for confounders including age, systolic blood pressure, and HDL-cholesterol identified by multiple regression analysis, the mean CAVI decreased progressively as BMI tertile increased in both genders. Furthermore, a negative inverse relationship between BMI and adjusted CAVI was observed throughout the BMI distribution. Multivariate logistic regression model for contributors of high CAVI (≥90th percentile) identified obesity (odds ratios (95% confidence interval): 0.804 (0.720-0.899)], older age [15.6 (14.0-17.4)], male gender [2.26 (2.03-2.51)], hypertension [2.28 (2.06-2.54)], impaired fasting glucose [1.17 (1.01-1.37)], and low HDL-cholesterol [0.843 (0.669-1.06)] as independent factors. We demonstrated an inverse relationship between CAVI and BMI in healthy Japanese subjects, suggesting that systemic accumulation of adipose tissue per se may lead to a linear decrease of arterial stiffness in nonobese and obese subjects without metabolic disorders.

  13. A spinach O-acetylserine(thiollyase homologue, SoCSaseLP, suppresses cysteine biosynthesis catalysed by other enzyme isoforms

    Directory of Open Access Journals (Sweden)

    Miki Noda

    2016-06-01

    Full Text Available An enzyme, O-acetylserine(thiollyase (OASTL, also known as O-acetylserine sulfhydrylase or cysteine synthase (CSase, catalyses the incorporation of sulfide into O-acetylserine and produces cysteine. We previously identified a cDNA encoding an OASTL-like protein from Spinacia oleracea, (SoCSaseLP, but a recombinant SoCSaseLP produced in Escherichia coli did not show OASTL activity. The exon-intron structure of the SoCSaseLP gene shared conserved structures with other spinach OASTL genes. The SoCSaseLP and a Beta vulgaris homologue protein, KMT13462, comprise a unique clade in the phylogenetic tree of the OASTL family. Interestingly, when the SoCSaseLP gene was expressed in tobacco plants, total OASTL activity in tobacco leaves was reduced. This reduction in total OASTL activity was most likely caused by interference by SoCSaseLP with cytosolic OASTL. To investigate the possible interaction of SoCSaseLP with a spinach cytosolic OASTL isoform SoCSaseA, a pull-down assay was carried out. The recombinant glutathione S-transferase (GST-SoCSaseLP fusion protein was expressed in E. coli together with the histidine-tagged SoCSaseA protein, and the protein extract was subjected to glutathione affinity chromatography. The histidine-tagged SoCSaseA was co-purified with the GST-SoCSaseLP fusion protein, indicating the binding of SoCSaseLP to SoCSaseA. Consistent with this interaction, the OASTL activity of the co-purified SoCSaseA was reduced compared with the activity of SoCSaseA that was purified on its own. These results strongly suggest that SoCSaseLP negatively regulates the activity of other cytosolic OASTL family members by direct interaction.

  14. Glycemic variability in relation to oral disposition index in the subjects with different stages of glucose tolerance.

    Science.gov (United States)

    Chen, Tong; Xu, Feng; Su, Jian-Bin; Wang, Xue-Qin; Chen, Jin-Feng; Wu, Gang; Jin, Yan; Wang, Xiao-Hua

    2013-01-01

    Glucose variability could be an independent risk factor for diabetes complications in addition to average glucose. The deficiency in islet β cell secretion and insulin sensitivity, the two important pathophysiological mechanisms of diabetes, are responsible for glycemic disorders. The oral disposition index evaluated by product of insulin secretion and sensitivity is a useful marker of islet β cell function. The aim of the study is to investigate glycemic variability in relation to oral disposition index in the subjects across a range of glucose tolerance from the normal to overt type 2 diabetes. 75-g oral glucose tolerance test (OGTT) was performed in total 220 subjects: 47 with normal glucose regulation (NGR), 52 with impaired glucose metabolism (IGM, 8 with isolated impaired fasting glucose [IFG], 18 with isolated impaired glucose tolerance [IGT] and 26 with combined IFG and IGT), 61 screen-diagnosed diabetes by isolated 2-h glucose (DM2h) and 60 newly diagnosed diabetes by both fasting and 2-h glucose (DM). Insulin sensitivity index (Matsuda index, ISI), insulin secretion index (ΔI30/ΔG30), and integrated β cell function measured by the oral disposition index (ΔI30/ΔG30 multiplied by the ISI) were derived from OGTT. All subjects were monitored using the continuous glucose monitoring system for consecutive 72 hours. The multiple parameters of glycemic variability included the standard deviation of blood glucose (SD), mean of blood glucose (MBG), high blood glucose index (HBGI), continuous overlapping net glycemic action calculated every 1 h (CONGA1), mean of daily differences (MODD) and mean amplitude of glycemic excursions (MAGE). From the NGR to IGM to DM2h to DM group, the respective values of SD (mean ± SD) (0.9 ± 0.3, 1.5 ± 0.5, 1.9 ± 0.6 and 2.2 ± 0.6 mmol/), MBG (5.9 ± 0.5, 6.7 ± 0.7, 7.7 ± 1.0 and 8.7 ± 1.5 mmol/L), HGBI [median(Q1-Q3)][0.8(0.2-1.2), 2.0(1.2-3.7), 3.8(2.4-5.6) and 6

  15. Quality of pharmacy-specific Medical Subject Headings (MeSH) assignment in pharmacy journals indexed in MEDLINE.

    Science.gov (United States)

    Minguet, Fernando; Salgado, Teresa M; van den Boogerd, Lucienne; Fernandez-Llimos, Fernando

    2015-01-01

    The Medical Subject Headings (MeSH) is the National Library of Medicine (NLM) controlled vocabulary for indexing articles. Inaccuracies in the MeSH thesaurus have been reported for several areas including pharmacy. To assess the quality of pharmacy-specific MeSH assignment to articles indexed in pharmacy journals. The 10 journals containing the highest number of articles published in 2012 indexed under the MeSH 'Pharmacists' were identified. All articles published over a 5-year period (2008-2012) in the 10 previously selected journals were retrieved from PubMed. MeSH terms used to index these articles were extracted and pharmacy-specific MeSH terms were identified. The frequency of use of pharmacy-specific MeSH terms was calculated across journals. A total of 6989 articles were retrieved from the 10 pharmacy journals, of which 328 (4.7%) were articles not fully indexed and therefore did not contain any MeSH terms assigned. Among the 6661 articles fully indexed, the mean number of MeSH terms was 10.1 (SD = 4.0), being 1.0 (SD = 1.3) considered as Major MeSH. Both values significantly varied across journals. The mean number of pharmacy-specific MeSH terms per article was 0.9 (SD = 1.2). A total of 3490 (52.4%) of the 6661 articles were indexed in pharmacy journals without a single pharmacy-specific MeSH. Of the total 67193 MeSH terms assigned to articles, on average 10.5% (SD = 13.9) were pharmacy-specific MeSH. A statistically significant different pattern of pharmacy-specific MeSH assignment was identified across journals (Kruskal-Wallis P MeSH terms to articles indexed in pharmacy journals can be improved to further enhance evidence gathering in pharmacy. Over half of the articles published in the top-10 journals publishing pharmacy literature were indexed without a single pharmacy-specific MeSH. Copyright © 2015 Elsevier Inc. All rights reserved.

  16. Inverse relationship of cardioankle vascular index with BMI in healthy Japanese subjects: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Nagayama D

    2016-12-01

    Full Text Available Daiji Nagayama,1,2 Haruki Imamura,2 Yuta Sato,2 Takashi Yamaguchi,2 Noriko Ban,2 Hidetoshi Kawana,2 Masahiro Ohira,2 Atsuhito Saiki,2 Kohji Shirai,3 Ichiro Tatsuno2 1Center of Endocrinology and Metabolism, Shin-Oyama City Hospital, Oyama-City, 2Center of Diabetes, Endocrinology and Metabolism, 3Department of Vascular Function, Sakura Medical Center, Toho University, Sakura-City, Japan Objective: The objective of this study is to investigate the association of body mass index (BMI with arterial stiffness assessed by cardioankle vascular index (CAVI. Subjects and methods: A retrospective cross-sectional study was conducted in 23,257 healthy Japanese subjects (12,729 men and 10,528 women, aged 47.1 ± 12.5 years, BMI 22.9 ± 3.4 kg/m2 who underwent health screening between 2004 and 2006 in Japan. Exclusion criteria were current medication use and a past history of cardiovascular disease, hypertension, stroke, diabetes, and nephritis. Results: Male subjects showed significantly higher BMI, CAVI, and triglycerides and lower high-density lipoprotein (HDL-cholesterol compared with female subjects. Next, the subjects were divided into tertiles of BMI: lower, middle, and upper, in a gender-specific manner. After adjusting for confounders including age, systolic blood pressure, and HDL-cholesterol identified by multiple regression analysis, the mean CAVI decreased progressively as BMI tertile increased in both genders. Furthermore, a negative inverse relationship between BMI and adjusted CAVI was observed throughout the BMI distribution. Multivariate logistic regression model for contributors of high CAVI (≥90th percentile identified obesity (odds ratios (95% confidence interval: 0.804 (0.720–0.899], older age [15.6 (14.0–17.4], male gender [2.26 (2.03–2.51], hypertension [2.28 (2.06–2.54], impaired fasting glucose [1.17 (1.01–1.37], and low HDL-cholesterol [0.843 (0.669–1.06] as independent factors. Conclusion: We demonstrated an

  17. Indexed

    CERN Document Server

    Hagy, Jessica

    2008-01-01

    Jessica Hagy is a different kind of thinker. She has an astonishing talent for visualizing relationships, capturing in pictures what is difficult for most of us to express in words. At indexed.blogspot.com, she posts charts, graphs, and Venn diagrams drawn on index cards that reveal in a simple and intuitive way the large and small truths of modern life. Praised throughout the blogosphere as “brilliant,” “incredibly creative,” and “comic genius,” Jessica turns her incisive, deadpan sense of humor on everything from office politics to relationships to religion. With new material along with some of Jessica’s greatest hits, this utterly unique book will thrill readers who demand humor that makes them both laugh and think.

  18. 75 FR 39680 - Houston Pipe Line Company LP, Worsham-Steed Gas Storage, L.P., Energy Transfer Fuel, LP, Mid...

    Science.gov (United States)

    2010-07-12

    ... Storage, L.P., Energy Transfer Fuel, LP, Mid Continent Market Center, L.L.C., Oasis Pipeline, LP (Not... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-44-000; Docket No. PR10-46-000; Docket No. PR10-48...

  19. Malocclusion and orthodontic treatment need evaluated among subjects with Down syndrome using the Dental Aesthetic Index (DAI).

    Science.gov (United States)

    Abdul Rahim, Farah S; Mohamed, Alizae M; Nor, Murshida Marizan; Saub, Roslan

    2014-07-01

    To determine the prevalence of malocclusion and need for orthodontic treatment among persons with Down Syndrome (DS). Study participants were 113 persons with DS from the selected community-based rehabilitation center who fulfilled the inclusion and exclusion criteria. Ten occlusal characteristics of the Dental Aesthetic Index (DAI) were measured on study models to determine the degree of malocclusion. A single score represented the dentofacial anomalies, determined the level of severity, and determined the need for orthodontic treatment. Crowding in the anterior maxillary and mandibular arch was the main malocclusion problems among the subjects with DS. Comparison between age group and genders revealed no significant differences in four categories of orthodontic treatment need (P > .05). Most of the subjects with DS (94; 83.2%) had severe and very severe malocclusion, which indicated a desirable and mandatory need for orthodontic treatment.

  20. Associations of Subjective Social Status with Physical Activity and Body Mass Index across Four Asian Countries

    Directory of Open Access Journals (Sweden)

    Leah Frerichs

    2014-01-01

    Full Text Available Objective. The aims of this study were to (1 assess physical activity and weight status differences and (2 explore the direction and shape of subjective social status (SSS association with physical activity and weight status within four Asian countries. Methods. Cross section data of adult respondents from the nationally representative East Asian Social Survey were used for analyses. Logistic regression stratified by gender was conducted for the first aim, and simple and quadratic logistic regression models were used for the second. Results. SSS was significantly associated with odds of weekly or daily physical activity across all countries and genders, except for South Korean and Japanese females. Quadratic models provided significantly better fit for Chinese males (LR (d.f. = 1 = 6.51, P value <.05 and females (LR (d.f. = 1 = 7.36, P value <.01, South Korean males (LR (d.f. = 1 = 4.40, P value <.05, and Taiwanese females (LR (d.f. = 1 = 4.87, P value <.05. Conclusions. This study provides a comparable cross Asian country measure of moderate-to-vigorous physical activity and new findings that a connection exists between SSS and physical activity. Differences of class distinction help explain the different shaped SSS relationships.

  1. Sampling with removal in LP-type problems

    Directory of Open Access Journals (Sweden)

    Bernd Gärtner

    2015-02-01

    Full Text Available Random sampling is an important tool in optimization subject to finitely or infinitely many constraints. Here we are interested in obtaining solutions of low cost that violate only few constraints. Under convexity or similar favorable conditions, and assuming fixed dimension, one can indeed derive combinatorial bounds on the expected number (or probability mass of constraints violated by the optimal solution subject to a (small random sample of  constraints. The cost of the sample solution, however, cannot be bounded combinatorially.Suppose that after picking the sample, we remove $k$ constraints from it in such a way that the best improvement of objective function is achieved. Can we still guarantee (good bounds on the number or mass of violated constraints?  This question was asked and  partially answered in the framework of chance-constrained optimization.Here we study the question in the completely combinatorial setting LP-type problems, which allows a unified treatment of many different optimization problems. Given a nondegenerate LP-type problem of combinatorial dimension $\\delta$, we consider sampling with subsequent removal of the $k$ constraints that lead to the best improvement of objective function. We show that this induces an LP-type problem of combinatorial dimension $O(\\delta^{k+1}$, and that this bound is tight in the worst case. It follows that through this kind of removal, the expected number of violated constraints blows up by a factor of at most $O(\\delta^{k}$; for relevant sample sizes, however, a matching lower bound for the blowup factor is not implied. At the same time, our results show that further improvements require new tools that go beyond combinatorial dimension.

  2. Transcranial direct current stimulation improves the QT variability index and autonomic cardiac control in healthy subjects older than 60 years

    Directory of Open Access Journals (Sweden)

    Piccirillo G

    2016-11-01

    Full Text Available Gianfranco Piccirillo,1 Cristina Ottaviani,2 Claudia Fiorucci,1 Nicola Petrocchi,2 Federica Moscucci,1 Claudia Di Iorio,1 Fabiola Mastropietri,1 Ilaria Parrotta,1 Matteo Pascucci,1 Damiano Magrì3 1Department of Cardiovascular, Respiratory, Nephrological, Anestesiological and Geriatric Sciences, “Sapienza” University, 2Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, 3Department of Clinical and Molecular Medicine, University of Rome “Sapienza”, Rome, Italy Background: Noninvasive brain stimulation technique is an interesting tool to investigate the causal relation between cortical functioning and autonomic nervous system (ANS responses. Objective: The objective of this report is to evaluate whether anodal transcranial direct current stimulation (tDCS over the temporal cortex influences short-period temporal ventricular repolarization dispersion and cardiovascular ANS control in elderly subjects. Subjects and methods: In 50 healthy subjects (29 subjects younger than 60 years and 21 subjects older than 60 years matched for gender, short-period RR and systolic blood pressure spectral variability, QT variability index (QTVI, and noninvasive hemodynamic data were obtained during anodal tDCS or sham stimulation. Results: In the older group, the QTVI, low-frequency (LF power expressed in normalized units, the ratio between LF and high-frequency (HF power, and systemic peripheral resistances decreased, whereas HF power expressed in normalized units and α HF power increased during the active compared to the sham condition (P<0.05. Conclusion: In healthy subjects older than 60 years, tDCS elicits cardiovascular and autonomic changes. Particularly, it improves temporal ventricular repolarization dispersion, reduces sinus sympathetic activity and systemic peripheral resistance, and increases vagal sinus activity and baroreflex sensitivity. Keywords: transcranial direct current stimulation, QT variability, heart rate variability

  3. Leg joint power output during progressive resistance FES-LCE cycling in SCI subjects: developing an index of fatigue

    Directory of Open Access Journals (Sweden)

    Faghri Pouran D

    2008-04-01

    Full Text Available Abstract Background The purpose of this study was to investigate the biomechanics of the hip, knee and ankle during a progressive resistance cycling protocol in an effort to detect and measure the presence of muscle fatigue. It was hypothesized that knee power output can be used as an indicator of fatigue in order to assess the cycling performance of SCI subjects. Methods Six spinal cord injured subjects (2 incomplete, 4 complete between the ages of twenty and fifty years old and possessing either a complete or incomplete spinal cord injury at or below the fourth cervical vertebra participated in this study. Kinematic data and pedal forces were recorded during cycling at increasing levels of resistance. Ankle, knee and hip power outputs and resultant pedal force were calculated. Ergometer cadence and muscle stimulation intensity were also recorded. Results The main findings of this study were: (a ankle and knee power outputs decreased, whereas hip power output increased with increasing resistance, (b cadence, stimulation intensity and resultant pedal force in that combined order were significant predictors of knee power output and (c knowing the value of these combined predictors at 10 rpm, an index of fatigue can be developed, quantitatively expressing the power capacity of the knee joint with respect to a baseline power level defined as fatigue. Conclusion An index of fatigue was successfully developed, proportionalizing knee power capacity during cycling to a predetermined value of fatigue. The fatigue index value at 0/8th kp, measured 90 seconds into active, unassisted pedaling was 1.6. This indicates initial power capacity at the knee to be 1.6 times greater than fatigue. The fatigue index decreased to 1.1 at 2/8th kp, representing approximately a 30% decrease in the knee's power capacity within a 4 minute timespan. These findings suggest that the present cycling protocol is not sufficient for a rider to gain the benefits of FES and thus

  4. Reliability of the Kinematic Steadiness Index during one-leg standing in subjects with recurrent low back pain.

    Science.gov (United States)

    Sung, Paul S; Danial, Pamela; Lee, Dongchul C

    2017-10-04

    To assess the reliability of standing time and the Kinematic Steadiness Index (KSI) in one-leg standing compared with the Timed Up and Go (TUG) test while considering anthropometric factors in subjects with recurrent low back pain (LBP). Sixty-six individuals participated in the study. The data were collected on two different days, 1 week apart. The KSI of the core spine, using video motion-capture techniques, was based on the relative standing time and relative standstill time. The intraclass correlation coefficient (ICC2,1) was compared for the reliability between measures. The covariates, such as age, Body Mass Index, and the Oswestry Disability Index (ODI), were analyzed for any interactions based on these measures. The standing time (t = - 1.01, p = 0.32) and the KSI (t = - 1.70, p = 0.09) were not significantly different between measures. The TUG results were not different between measures (t = 1.01, p = 0.32). The Cronbach's alpha for the standing time was 0.84, for KSI was 0.89, and for TUG was 0.76. The standing time and KSI demonstrated an interaction with age, while the TUG demonstrated an interaction with the ODI score. The KSI during one-leg standing could help to develop a practical tool to justify quantity and quality of balance outcome measures, which identify balance deficits and core spine rehabilitation strategies in subjects with recurrent LBP.

  5. Association of Lp-PLA2 Mass and Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients.

    Science.gov (United States)

    Wang, Yan; Zhang, Jin; Qian, Yuesheng; Tang, Xiaofeng; Ling, Huawei; Chen, Kemin; Gao, Pingjin; Zhu, Dingliang

    2015-01-01

    Intracranial arterial stenosis (ICAS) is a common cause of ischemic stroke in Asians, whereas whites tend to have more extracranial lesions. Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been associated with ischemic stroke by a large amount of work. However, there are few studies focusing on the relationship of Lp-PLA2 and asymptomatic ICAS or extracranial arterial stenosis (ECAS). Wehereby sought to explore the relationship of Lp-PLA2 and ICAS, ECAS and concurrent stenosis in stroke-free hypertensive patients in Chinese population. All the subjects were evaluated for the presence and severity of ICAS and ECAS through computerized tomographic angiography (CTA) covered the whole brain down to the level of aortic arch. Lp-PLA2 mass was measured by enzyme linked immunoassay. The association of Lp-PLA2 and vascular stenosis was analyzed through multivariate logistic regression. Among 414 participants, 163 (39.4%) had no ICAS or ECAS, 63 (15.2%) had ECAS only, 111 (26.8%) had ICAS only and 77 (18.6%) had concurrent extraintracranial stenosis. Lp-PLA2 mass was significantly associated with isolated ICAS (OR: 2.3; 95% CI: 1.14-4.64), and concurrent stenosis (OR: 3.93; 95% CI: 1.62-9.51), but was not related to isolated ECAS (OR: 1.54; 95% CI: 0.68-3.48). Lp-PLA2 mass was also associated with moderate to severe ICAS no matter how was the ECAS. Moreover, patients with higher Lp-PLA2 mass showed more sever ICAS and had more intracranial arterial lesions. This study revealed the association of Lp-PLA2 mass with ICAS in stroke-free hypertensive patients in Chinese population. The further long-term cohort study was warranted to elucidate the concrete effect of Lp-PLA2 on the asymptomatic ICAS.

  6. Glycemic index of split peas, rice (Binam, kidney beans, green peas, "Lavash" bread and broad bean kernels in NIDDM subjects

    Directory of Open Access Journals (Sweden)

    Darabi A

    2000-09-01

    Full Text Available Equal amounts of carbohydrates from various foodstuffs do not increase blood glucose to the same extent. This study was carried out, therefore, in 1996 at the National Nutrition and Food Technology Research institute in Tehran to determine the glycemic index of split pease, rice (Binam, kidney beans, green peas, “Lavash” bread and broad bean kernels. Diabetic subjects were studied in a clinical trial. The exact amount of cabohydrate in foodstuffs was determined using AOAC. Methods. White bread was used as the reference food. After a 12-hour overnight fast on seven separate days each subject was given the test food in an amount to provide 25 g of carbohydrate. Blood glucose was determined after 0, 60, 120 minutes using orthotouidine method. Glycemi response in each individual was calculated as the area under the 2- hour glucose individual was calculated as the area under the test food glucose curve as a percentage of the mean area under the whith bread glucose curve. Glycemic indices of the test foods were 31± 8.5 for split peas, 42.9±3 for rice, 44±9 for kidney beans, 57±7 for green peas, 69±8.5 for “Lavash” bread, and 96±14 for broad bean kernels .Legumes and rice (Binam can be used efficiently in meal planning for the diabetic subjects.

  7. A unified treatment for Lp Brunn-Minkowski type inequalities

    OpenAIRE

    Zou, Du; Xiong, Ge

    2016-01-01

    A unified approach used to generalize classical Brunn-Minkowski type inequalities to Lp Brunn-Minkowski type inequalities, called the Lp transference principle, is refined in this paper. As illustrations of the effectiveness and practicability of this method, several new Lp Brunn-Minkowski type inequalities concerning the mixed volume, moment of inertia, quermassintegral, projection body and capacity are established.

  8. Directory of Book Trade and Related Organizations. Books Trade Associations, United States and Canada; International and Foreign Book Trade Associations; National Information Standards Organization (NISO) Standards; Calendar, 2003-2012; Acronyms; Index of Organizations; Subject Index.

    Science.gov (United States)

    Bowker Annual Library and Book Trade Almanac, 2003

    2003-01-01

    Includes two lists: one of book trade associations in the United States and Canada, and one of international and foreign book trade associations. Concludes with National Information Standards Organization (NISO) standards; calendar, 2003-2012; acronyms; index of organizations; and subject index. (LRW)

  9. The value of the acoustic voice quality index as a measure of dysphonia severity in subjects speaking different languages.

    Science.gov (United States)

    Maryn, Youri; De Bodt, Marc; Barsties, Ben; Roy, Nelson

    2014-06-01

    The Acoustic Voice Quality Index (AVQI) is a relatively new clinical method to quantify dysphonia severity. Since it partially relies on continuous speech, its performance may vary with voice-related phonetic differences and thus across languages. The present investigation therefore assessed the AVQI's performance in English, Dutch, German, and French. Fifty subjects were recorded reading sentences in the four languages, as well as producing a sustained vowel. These recordings were later edited to calculate the AVQI. The samples were also perceptually rated on overall dysphonia severity by three experienced voice clinicians. The AVQI's cross-linguistic concurrent validity and diagnostic precision were assessed. The results support earlier data, and confirm good cross-linguistic validity and diagnostic accuracy. Although no statistical differences were observed between languages, the AVQI performed better in English and German and less well in French. These results validate the AVQI as a potentially robust and objective dysphonia severity measure across languages.

  10. Haplotype structure of the beta2-adrenergic receptor gene in 814 Danish Caucasian subjects and association with body mass index

    DEFF Research Database (Denmark)

    Jensen, Mette Kamp; Nielsen, Morten; Koefoed, Pernille

    2009-01-01

    Several single nucleotide polymorphisms (SNPs) have been identified in the beta(2)-adrenergic receptor gene (ADRB2). By the use of five SNPs (G46A, C79G, C491T, C523A, G1053C) for identification of ADRB2 haplotypes in 814 Danish Caucasians, we investigated whether ADRB2 haplotypes are associated...... with body mass index (BMI). The SNPs showed organization into 13 distinct haplotypes and 41 haplotype pairs. The study identified four common haplotypes: ACCCC (10.1 +/- 0.3 %), ACCCG (27.9 +/- 0.3 %), GCCAC (10.8 +/- 0.1 %) and GGCCG (41.0 +/- 0.2 %) (frequencies (SD), seen in 91 % of the population....... In the total population (mean age +/- SD: 50 +/- 16 years), BMI was not related to haplotype pairs, individual SNPs or allelic haplotypes. However, in subjects haplotype groups (p = 0.014) but were not related...

  11. The acute effect of various glycemic index dietary carbohydrates on endothelial function in nondiabetic overweight and obese subjects.

    Science.gov (United States)

    Lavi, Talya; Karasik, Avraham; Koren-Morag, Nira; Kanety, Hannah; Feinberg, Micha S; Shechter, Michael

    2009-06-16

    This study sought to explore the effect of glycemic-index dietary carbohydrates on endothelium-dependent flow-mediated dilation (FMD) in overweight and obese nondiabetic volunteers. Post-prandial hyperglycemia has been recognized as a cardiovascular risk factor in both the diabetic and the general population. Endothelial dysfunction has been shown to occur in diabetic and hyperglycemic patients. We prospectively assessed brachial artery FMD in 56 healthy overweight and obese nondiabetic volunteers (38 [67.9%] men, mean age 48 +/- 6 years) on 4 separate mornings, 1 to 2 weeks apart. After overnight fasting, the percent FMD (%FMD) improvement and endothelium-independent nitroglycerin-mediated dilation (%NTG) were assessed, after which subjects received 1 of 4 group meals at each visit (placebo [water] or a carbohydrate meal of glucose, cornflakes, or high-fiber cereal). Meals were distributed in a rotating randomized fashion, such that each subject received all 4 meals once throughout the study period. Fasting and 2-h post-prandial serum glucose levels were similar in all 3 meals, whereas at 30 to 90 min, serum glucose levels were significantly higher after glucose and cornflakes (high glycemic) compared with fiber (low glycemic). Baseline %FMD, not significantly different in the 3 carbohydrate-based meals, was reduced 2 h post-prandially in all groups, showing statistical significance in only high-glycemic index meals: glucose (15 +/- 9% vs. 10 +/- 8%, p glycemic carbohydrate consumption significantly suppresses FMD in nondiabetic overweight and obese volunteers, suggesting a mechanism whereby high-glycemic meals may enhance cardiovascular risk.

  12. 75 FR 20870 - Montreux Equity Partners II SBIC, L.P.; Montreux Equity Partners III SBIC, L.P.; Notice Seeking...

    Science.gov (United States)

    2010-04-21

    ... ADMINISTRATION Montreux Equity Partners II SBIC, L.P.; Montreux Equity Partners III SBIC, L.P.; Notice Seeking... given that Montreux Equity Partners II SBIC, L.P. and Montreux Equity Partners III SBIC, L.P., 3000 Sand...). Montreux Equity Partners III SBIC, L.P. proposes to sell part of its equity interest in Renal CarePartners...

  13. A 14-item Mediterranean diet assessment tool and obesity indexes among high-risk subjects: the PREDIMED trial.

    Directory of Open Access Journals (Sweden)

    Miguel Angel Martínez-González

    Full Text Available OBJECTIVE: Independently of total caloric intake, a better quality of the diet (for example, conformity to the Mediterranean diet is associated with lower obesity risk. It is unclear whether a brief dietary assessment tool, instead of full-length comprehensive methods, can also capture this association. In addition to reduced costs, a brief tool has the interesting advantage of allowing immediate feedback to participants in interventional studies. Another relevant question is which individual items of such a brief tool are responsible for this association. We examined these associations using a 14-item tool of adherence to the Mediterranean diet as exposure and body mass index, waist circumference and waist-to-height ratio (WHtR as outcomes. DESIGN: Cross-sectional assessment of all participants in the "PREvención con DIeta MEDiterránea" (PREDIMED trial. SUBJECTS: 7,447 participants (55-80 years, 57% women free of cardiovascular disease, but with either type 2 diabetes or ≥ 3 cardiovascular risk factors. Trained dietitians used both a validated 14-item questionnaire and a full-length validated 137-item food frequency questionnaire to assess dietary habits. Trained nurses measured weight, height and waist circumference. RESULTS: Strong inverse linear associations between the 14-item tool and all adiposity indexes were found. For a two-point increment in the 14-item score, the multivariable-adjusted differences in WHtR were -0.0066 (95% confidence interval, -0.0088 to -0.0049 for women and -0.0059 (-0.0079 to -0.0038 for men. The multivariable-adjusted odds ratio for a WHtR>0.6 in participants scoring ≥ 10 points versus ≤ 7 points was 0.68 (0.57 to 0.80 for women and 0.66 (0.54 to 0.80 for men. High consumption of nuts and low consumption of sweetened/carbonated beverages presented the strongest inverse associations with abdominal obesity. CONCLUSIONS: A brief 14-item tool was able to capture a strong monotonic inverse association between

  14. A 14-Item Mediterranean Diet Assessment Tool and Obesity Indexes among High-Risk Subjects: The PREDIMED Trial

    Science.gov (United States)

    Martínez-González, Miguel Angel; García-Arellano, Ana; Toledo, Estefanía; Salas-Salvadó, Jordi; Buil-Cosiales, Pilar; Corella, Dolores; Covas, Maria Isabel; Schröder, Helmut; Arós, Fernando; Gómez-Gracia, Enrique; Fiol, Miquel; Ruiz-Gutiérrez, Valentina; Lapetra, José; Lamuela-Raventos, Rosa Maria; Serra-Majem, Lluís; Pintó, Xavier; Muñoz, Miguel Angel; Wärnberg, Julia; Ros, Emilio; Estruch, Ramón

    2012-01-01

    Objective Independently of total caloric intake, a better quality of the diet (for example, conformity to the Mediterranean diet) is associated with lower obesity risk. It is unclear whether a brief dietary assessment tool, instead of full-length comprehensive methods, can also capture this association. In addition to reduced costs, a brief tool has the interesting advantage of allowing immediate feedback to participants in interventional studies. Another relevant question is which individual items of such a brief tool are responsible for this association. We examined these associations using a 14-item tool of adherence to the Mediterranean diet as exposure and body mass index, waist circumference and waist-to-height ratio (WHtR) as outcomes. Design Cross-sectional assessment of all participants in the “PREvención con DIeta MEDiterránea” (PREDIMED) trial. Subjects 7,447 participants (55–80 years, 57% women) free of cardiovascular disease, but with either type 2 diabetes or ≥3 cardiovascular risk factors. Trained dietitians used both a validated 14-item questionnaire and a full-length validated 137-item food frequency questionnaire to assess dietary habits. Trained nurses measured weight, height and waist circumference. Results Strong inverse linear associations between the 14-item tool and all adiposity indexes were found. For a two-point increment in the 14-item score, the multivariable-adjusted differences in WHtR were −0.0066 (95% confidence interval, –0.0088 to −0.0049) for women and –0.0059 (–0.0079 to –0.0038) for men. The multivariable-adjusted odds ratio for a WHtR>0.6 in participants scoring ≥10 points versus ≤7 points was 0.68 (0.57 to 0.80) for women and 0.66 (0.54 to 0.80) for men. High consumption of nuts and low consumption of sweetened/carbonated beverages presented the strongest inverse associations with abdominal obesity. Conclusions A brief 14-item tool was able to capture a strong monotonic inverse association between

  15. Inter-examiner reproducibility of Ocular Response Analyzer using the waveform score quality index in healthy subjects.

    Science.gov (United States)

    Mandalos, Achilleas; Anastasopoulos, Eleftherios; Makris, Leonidas; Dervenis, Nikolaos; Kilintzis, Vasilis; Topouzis, Fotis

    2013-02-01

    To evaluate the inter-examiner reproducibility of Ocular Response Analyzer (ORA) parameters in healthy subjects using the waveform score (WS) for quality control of acquisition. Fifteen healthy subjects had their intraocular pressure (IOP) measured with ORA by 2 masked examiners. An acquisition protocol that aimed at obtaining 4 reliable measurements in each eye with WS≥6 and with as few repeated measurements as possible was employed, whereas a maximum of 8 measurements per eye was allowed. Additional good quality criteria included symmetrical force-in and force-out applanation signal peaks on the ORA waveform and few or no distortions of the applanation signal curve. Only the right eyes were included in the analysis. Examiners were trained but not experienced. The inter-examiner reproducibility of ORA parameters was assessed using the intraclass correlation coefficient (ICC). Mean values of the best 4 measurements were considered in analysis. ICC including the best 4 measurements per eye was high for all ORA parameters. Specifically, ICC for Goldmann-correlated IOP was 0.961, for corneal-compensated IOP was 0.962, for corneal resistance factor was 0.987, and for corneal hysteresis was 0.988. Similar reproducibility was found when only the 3 best measurements per eye were included in the analysis. The protocol for IOP measurement with ORA using the WS ≥6 as quality index achieved high inter-examiner reproducibility for all ORA parameters. High reproducibility was obtained even by inexperienced examiners when considering the mean of the best 3 measurements per eye.

  16. The Land Processes Distributed Active Archive Center (LP DAAC)

    Science.gov (United States)

    Golon, Danielle K.

    2016-10-03

    The Land Processes Distributed Active Archive Center (LP DAAC) operates as a partnership with the U.S. Geological Survey and is 1 of 12 DAACs within the National Aeronautics and Space Administration (NASA) Earth Observing System Data and Information System (EOSDIS). The LP DAAC ingests, archives, processes, and distributes NASA Earth science remote sensing data. These data are provided to the public at no charge. Data distributed by the LP DAAC provide information about Earth’s surface from daily to yearly intervals and at 15 to 5,600 meter spatial resolution. Data provided by the LP DAAC can be used to study changes in agriculture, vegetation, ecosystems, elevation, and much more. The LP DAAC provides several ways to access, process, and interact with these data. In addition, the LP DAAC is actively archiving new datasets to provide users with a variety of data to study the Earth.

  17. Large-scale international validation of the ADO index in subjects with COPD: an individual subject data analysis of 10 cohorts

    DEFF Research Database (Denmark)

    Puhan, Milo A; Hansel, Nadia N; Sobradillo, Patricia

    2012-01-01

    Background: Little evidence on the validity of simple and widely applicable tools to predict mortality in patients with chronic obstructive pulmonary disease (COPD) exists.Objective: To conduct a large international study to validate the ADO index that uses age, dyspnoea and FEV1 to predict 3-yea...

  18. Trigonometric bases for matrix weighted Lp-spaces

    DEFF Research Database (Denmark)

    Nielsen, Morten

    2010-01-01

    We give a complete characterization of 2π-periodic matrix weights W for which the vector-valued trigonometric system forms a Schauder basis for the matrix weighted space Lp(T;W). Then trigonometric quasi-greedy bases for Lp(T;W) are considered. Quasi-greedy bases are systems for which the simple...

  19. 76 FR 68745 - Seneca Power Partners, L.P.

    Science.gov (United States)

    2011-11-07

    ...] Seneca Power Partners, L.P. v. New York Independent System Operator, Inc.; Notice of Complaint Take... and Procedures, 18 CFR 385.206, Seneca Power Partners, L.P. (Complainant) filed a complaint against... TTY, call (202) 502-8659. Comment Date: 5 p.m. Eastern Time on November 28, 2011. Dated: October 28...

  20. 78 FR 16846 - Notice of Application; Equitrans, L.P.

    Science.gov (United States)

    2013-03-19

    ... Energy Regulatory Commission Notice of Application; Equitrans, L.P. Take notice that on March 1, 2013, Equitrans, L.P. (Equitrans), 625 Liberty Avenue, Suite 1700, Pittsburgh, Pennsylvania 15222, filed in Docket...: 5:00 p.m. Eastern Time on April 2, 2013. Dated: March 12, 2013. Kimberly D. Bose, Secretary. BILLING...

  1. The role of LP gas in eradicating energy poverty

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, Michael; Behuria, Sarthak

    2010-09-15

    LP Gas is an ideal solution for dealing with energy poverty. Clean burning, low carbon, extremely efficient, requiring minimal infrastructure or R and D investment and with plentiful long term global supply, LP Gas can be quickly introduced to play an important role in eradicating energy poverty and steering both industrialised and developing countries onto more sustainable energy development paths.

  2. Flygtninge på langvarig starthjælp

    DEFF Research Database (Denmark)

    Johansen, Adam; Højland, Marianne; Hansen, Henning

    Spørgeskema-, fokusgruppe- og interviewbaseret undersøgelse af personlige og sociale konsekvenser af familiers forsørgelse på starthjælp. Kvalitativ og kvantitativ undersøgelse af starthjælpens konsekvenser for flygtningefamilier med mere end 1 år på starthjælp...

  3. 76 FR 50881 - Airworthiness Directives; M7 Aerospace LP Airplanes

    Science.gov (United States)

    2011-08-17

    ...-025-AD; Amendment 39-16771; AD 2011-17-07] RIN 2120-AA64 Airworthiness Directives; M7 Aerospace LP.... SUMMARY: We are adopting a new airworthiness directive (AD) for certain M7 Aerospace LP Models SA226-T... AD, contact M7 Aerospace, LC, 10823 NE. Entrance Road, San Antonio, Texas 78216; telephone (210) 824...

  4. Clinical outcomes, radiologic kinematics, and effects on sagittal balance of the 6 df LP-ESP lumbar disc prosthesis.

    Science.gov (United States)

    Lazennec, Jean-Yves; Even, Julien; Skalli, Wafa; Rakover, Jean-Patrick; Brusson, Adrien; Rousseau, Marc-Antoine

    2014-09-01

    Surgical treatment of degenerative disc disease remains a controversial subject. Lumbar fusion has been associated with a potential risk of segmental junctional disease and sagittal balance misalignment. Motion preservation devices have been developed as an alternative to fusion. The LP-ESP disc is a one-piece deformable device achieving 6 df, including shock absorption and elastic return. This is the first clinical report on its use. To assess clinical outcomes and radiologic kinematics in the first 2 years after implantation. Prospective cohort of patients with LP-ESP total disc replacement (TDR) at the lumbar spine. Forty-six consecutive patients. Clinical outcomes were the visual analog scale (VAS) for pain, the Oswestry disability index (ODI), and the GHQ28 (General Health Questionnaire) psychological score. Radiologic data were the range of motion (ROM), sagittal balance parameters, and mean center of rotation (MCR). Patients had single-level TDR at L4-L5 or L5-S1. Outcomes were prospectively recorded for 2 years (before and at 3, 6, 12, and 24 months after surgery). The SpineView software was used for computed analysis of the radiographic data. Paired t tests were used for statistical comparisons. No intraoperative complication occurred. All clinical scores improved significantly at 24 months: the back pain VAS scores by a mean of 4.1 points and the ODI by 33 points. The average ROM of the instrumented level was 5.4°±4.8° at 2 years and more than 2° for 76% of prostheses. The MCR was in a physiological area in 73% of cases. The sagittal balance (pelvic tilt, sacral slope, and segmental lordosis) did not change significantly at any point of the follow-up. Results from the 2-year follow-up indicate that LP-ESP prosthesis recreates lumbar spine function similar to that of the healthy disc in terms of ROM, quality of movement, effect on sagittal balance, and absence of modification in the kinematics of the upper adjacent level. Copyright © 2014 Elsevier Inc

  5. Composition of The Knee Index, a novel three-dimensional biomechanical index for knee joint load, in subjects with mild to moderate knee osteoarthritis

    DEFF Research Database (Denmark)

    Clausen, Brian; Andriacchi, Tom; Nielsen, Dennis Brandborg

    osteoarthritis according to the ACR criteria. Three dimensional gait analysis was performed. Subjects walked barefoot at self-selected walking speed. The first peak magnitude KI from all three planes were calculated using inverse dynamics. Results Frontal plane kinematics contributed with 59.3% (SD 25.6) of KI...... while sagittal plane kinematics contributed with 40.5% (SD 26.1). A substantial inter-subject variation in the relative contribution of the flexion and extension moment components to KI was observed. Conclusion Our findings support the notion that the primary contributor to KI is the frontal plane...... kinematics (i.e. the knee adduction moment), and secondarily the sagittal plane kinematics (i.e. the knee flexion moment). This holds promise for using KI in clinical trials since both frontal and sagittal knee joint moments have been suggested to be associated with the knee osteoarthritis disease...

  6. The maximal operator in weighted variable spaces Lp(⋅

    Directory of Open Access Journals (Sweden)

    Vakhtang Kokilashvili

    2007-01-01

    Full Text Available We study the boundedness of the maximal operator in the weighted spaces Lp(⋅(ρ over a bounded open set Ω in the Euclidean space ℝn or a Carleson curve Γ in a complex plane. The weight function may belong to a certain version of a general Muckenhoupt-type condition, which is narrower than the expected Muckenhoupt condition for variable exponent, but coincides with the usual Muckenhoupt class Ap in the case of constant p. In the case of Carleson curves there is also considered another class of weights of radial type of the form ρ(t=∏k=1mwk(|t-tk|, tk∈Γ, where wk has the property that r1p(tkwk(r∈Φ10, where Φ10 is a certain Zygmund-Bari-Stechkin-type class. It is assumed that the exponent p(t satisfies the Dini–Lipschitz condition. For such radial type weights the final statement on the boundedness is given in terms of the index numbers of the functions wk (similar in a sense to the Boyd indices for the Young functions defining Orlich spaces.

  7. Lp(a-cholesterol is associated with HDL-cholesterol in overweight and obese African American children and is not an independent risk factor for CVD

    Directory of Open Access Journals (Sweden)

    Sharma Sushma

    2012-01-01

    Full Text Available Abstract Background The role of Lipoprotein (a cholesterol {Lp(a-C}as an additional and/or independent risk factor for cardiovascular disease (CVD is not clear. We evaluated the associations between Lp(a-C and other CVD risk factors including plasma lipoprotein concentrations and body fatness in overweight and obese African American children. Methods A cross-sectional analysis was carried out using data from a sample of 121 African American children aged 9-11 years with Body Mass Index (BMI's greater than the 85th percentile. Body height, weight and waist circumference (WC were measured. Fasting plasma concentrations of Lp(a-C, Total cholesterol (TC, High density lipoprotein cholesterol (HDL-C, Very low density lipoprotein cholesterol (VLDL-C, Intermediate density lipoprotein cholesterol (IDL-C, Low density lipoprotein cholesterol (LDL-C, and Triacylglycerides (TAG were analyzed using the vertical auto profile (VAP cholesterol method. Results After adjusting for child age, gender, and pubertal status, Lp(a-C was positively associated with both HDL-C and TC, and negatively associated with VLDL-C and TAG. Including BMIz and WC as additional covariates did not alter the direction of the relationships between Lp(a-C and the other lipoproteins. Finally, after adjusting for the other plasma lipoproteins, Lp(a-C remained strongly associated with HDL-C, whereas the associations of Lp(a-C with the other lipoproteins were not significant when HDL-C was simultaneously included in the regression models. Conclusions Lp(a-C was positively associated with HDL-C and this association is not influenced by other lipoprotein subclasses or by the degree of obesity. We conclude that Lp(a cholesterol is not an independent risk factor for CVD in African American children.

  8. Gradient Compared Lp-LMS Algorithms for Sparse System Identification

    OpenAIRE

    Feng, Yong; Wu, Jiasong; Zeng, Rui; Luo, Limin; Shu, Huazhong

    2015-01-01

    In this paper, we propose two novel p-norm penalty least mean square (Lp-LMS) algorithms as supplements of the conventional Lp-LMS algorithm established for sparse adaptive filtering recently. A gradient comparator is employed to selectively apply the zero attractor of p-norm constraint for only those taps that have the same polarity as that of the gradient of the squared instantaneous error, which leads to the new proposed gradient compared p-norm constraint LMS algorithm (LpGC-LMS). We expl...

  9. n-3 PUFA Esterified to Glycerol or as Ethyl Esters Reduce Non-Fasting Plasma Triacylglycerol in Subjects with Hypertriglyceridemia

    DEFF Research Database (Denmark)

    Hedengran, Anne; Szecsi, Pal B; Dyerberg, Jørn

    2015-01-01

    To date, treatment of hypertriglyceridemia with long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) has been investigated solely in fasting and postprandial subjects. However, non-fasting triacylglycerols are more strongly associated with risk of cardiovascular disease. The objective......-PUFA group (P omega-3 index (EPA + DHA content in erythrocyte membranes). The omega-3 index increased 63.2 % in the AG......-associated phospholipase A2 (LpPLA2) decreased in the EE-PUFA group (P = 0.001). No serious adverse events were observed. Supplementation with long-chain n-3 PUFA lowered non-fasting triacylglycerol levels, suggestive of a reduction in cardiovascular risk. Regardless of the different effects on heart rate, HDL, and LpPLA2...

  10. AppLP: A Dialogue on Applications of Logic Programming

    OpenAIRE

    Warren, David S.; Liu, Yanhong A.

    2017-01-01

    This document describes the contributions of the 2016 Applications of Logic Programming Workshop (AppLP), which was held on October 17 and associated with the International Conference on Logic Programming (ICLP) in Flushing, New York City.

  11. LP formulation of asymmetric zero-sum stochastic games

    KAUST Repository

    Li, Lichun

    2014-12-15

    This paper provides an efficient linear programming (LP) formulation of asymmetric two player zero-sum stochastic games with finite horizon. In these stochastic games, only one player is informed of the state at each stage, and the transition law is only controlled by the informed player. Compared with the LP formulation of extensive stochastic games whose size grows polynomially with respect to the size of the state and the size of the uninformed player\\'s actions, our proposed LP formulation has its size to be linear with respect to the size of the state and the size of the uninformed player, and hence greatly reduces the computational complexity. A travelling inspector problem is used to demonstrate the efficiency of the proposed LP formulation.

  12. Predictive Value of Kushida Index and Acoustic Pharyngometry for the Evaluation of Upper Airway in Subjects With or Without Obstructive Sleep Apnea

    Science.gov (United States)

    Cho, Hae Young; Grunstein, Ronald R; Yee, Brendon

    2004-01-01

    Acoustic pharyngometry is a relatively new noninvasive method that quantifies geometrically complexed pharyngeal dimensions. Our study aimed to investigate the predictability and usefulness of acoustic pharyngometry in diagnosis of obstructive sleep apnea (OSA), and we developed a prospective clinical trial in 16 subjects without apnea and 54 subjects with apnea. All seventy subjects received polysomnography (PSG) to assess the sleep architecture, including breathing and the degree of apnea hypopnea index. Acoustic pharyngometry was performed in four body positions (sitting, supine, right and left lateral) while awake with tidal breathing in addition to morphometric measurements (Kushida index) of oral cavity. This study shows that the cross-sectional area and volume of the upper airway is smaller in the supine position than any other positions. As well, the oropharyngeal junction area of the supine position is the most predictive parameter to discriminate between subjects with or without OSA. Acoustic pharyngometry can be a clinically useful tool for localizing the narrowed portion of the upper airway and predicting obstructive sleep apnea. PMID:15483340

  13. Glycaemic index of parboiled rice depends on the severity of processing: study in type 2 diabetic subjects

    DEFF Research Database (Denmark)

    Larsen, H. N.; Rasmussen, O. W.; Rasmussen, Peter Have

    2000-01-01

    diabetic subjects ingested four test meals: white bread (WB) and three meals of cooked polished rice of the same variety being non-parboiled (NP), mildly traditionally parboiled (TP) and severely pressure parboiled (PP). The participants ingested the test meals (50 g available carbohydrates) on separate...... white bread (626 +/- 80; P ... that to white bread (P

  14. A comparison of indexing methods to evaluate quality of soils subjected to different erosion: the role of soil microbiological properties.

    Science.gov (United States)

    Romaniuk, Romina; Lidia, Giuffre; Alejandro, Costantini; Norberto, Bartoloni; Paolo, Nannipieri

    2010-05-01

    Soil quality assessment is needed to evaluate the soil conditions and sustainability of soil and crop management properties, and thus requires a systematic approach to select and interpret soil properties to be used as indicators. The aim of this work was to evaluate and compare different indexing methods to assess quality of an undisturbed grassland soil (UN), a degraded pasture soil (GL) and a no tilled soil (NT) with four different A horizon depths (25, 23, 19 and 14 cm) reflecting a diverse erosion. Twenty four soil properties were measured from 0 to10 (1) and 10 to 20 cm. (2) and a minimum data set was chosen by multivariate principal component analysis (PCA) considering all measured soil properties together (A), or according to their classification in physical, chemical or microbiological (B) properties. The measured soil properties involved either inexpensive or not laborious standard protocols, to be used in routine laboratory analysis (simple soil quality index - SSQI), or a more laborious, time consuming and expensive protocols to determine microbial diversity and microbial functionality by methyl ester fatty acids (PLFA) and catabolic response profiles (CRP), respectively (complex soil quality index - CSQI). The selected properties were linearly normalized and integrated by the weight additive method to calculate SSQI A, SSQI B, CSQI A and CSQI B indices. Two microbiological soil quality indices (MSQI) were also calculated: the MSQI 1 only considered microbiological properties according to the procedure used for calculating SQI; the MSQI 2 was calculated by considering microbial carbon biomass (MCB), microbial activity (Resp) and functional diversity determined by CPR (E). The soil quality indices were SSQI A = MCB 1 + Particulate Organic Carbon (POC)1 + Mean Weight Diameter (MWD)1; SSQI B = Saturated hydraulic conductivity (K) 1 + Total Organic Carbon (TOC) 1 + MCB 1; CSQI A = MCB 1 + POC 1 + MWD 1; CSQI B = K 1+ TOC 1+ 0.3 * (MCB 1+ i/a +POC 1) + 0

  15. [Obesity and dyslipidemia in Tunisian bipolar subjects].

    Science.gov (United States)

    Ezzaher, Asma; Haj Mouhamed, Dhouha; Mechri, Anwar; Neffati, Fadoua; Douki, Wahiba; Gaha, Lotfi; Najjar, Mohamed Fadhel

    2010-01-01

    This study aims to investigate the prevalence of obesity and overweight and their association with lipid parameters in bipolar patients. Our study included 130 patients with bipolar disorder and 130 control subjects aged respectively 37.9 +/- 12.1 and 37.2 +/- 13.1 years. Obesity was evaluated by body mass index (BMI). Concentrations of total cholesterol, triglycerides, cLDL and cHDL were determined by enzymatic methods and ApoA1, ApoB and Lp(a) by techniques immunoturbidimetric. The prevalence of obesity in patients is 30.1% vs 12.3% in controls. A significant increase in BMI was noted in patients compared with controls regardless of sex and tobacco status and in patients aged less than 35 years and those consumers of alcohol. The majority of obese and overweight patients are treated with valproic acid. We found increase in cholesterol (4.41 +/- 1.02 vs 3.90 +/- 0.98 mmol/L), in cLDL (2.13 +/- 1.09 vs 1.29 +/- 0.56 mmol/L) and in Lp(a) (236 +/- 207 vs 163 +/- 150 mg/L) and decrease in HDLc (0.98 +/- 0.28 vs 1.09 +/- 0.36 mmol/L), more frequent at the obese patients and those presenting an overweight. In conclusion, in bipolar patients, obesity and overweight are frequent and associated with perturbations in lipid profile particularly an increase in total cholesterol, cLDL and Lp(a) and decrease in cHDL that increase the risk of cardiovascular disease.

  16. A comparative study of the origin, structure, and indexing language of the Persian and English keywords of articles indexed in the IranMedex database and their compliance with the Persian medical thesaurus and Medical Subject Headings.

    Science.gov (United States)

    Parsaei-Mohammadi, Parastoo; Ghasemi, Ali Hossein; Hassanzadeh-Beheshtabad, Raziyeh

    2017-01-01

    In the present era, thesauri as tools in indexing play an effective role in integrating retrieval preventing fragmentation as well as a multiplicity of terminologies and also in providing information content of documents. This study aimed to investigate the keywords of articles indexed in IranMedex in terms of origin, structure and indexing situation and their Compliance with the Persian Medical Thesaurus and Medical Subject Headings (MeSH). This study is an applied research, and a survey has been conducted. Statistical population includes 32,850 Persian articles which are indexed in the IranMedex during the years 1385-1391. 379 cases were selected as sample of the study. Data collection was done using a checklist. In analyzing the findings, the SPSS Software were used. Although there was no significant difference in terms of indexing origin between the proportion of different types of the Persian and English keywords of articles indexed in the IranMedex, the compliance rates of the Persian and English keywords with the Persian medical thesaurus and MeSH were different in different years. In the meantime, the structure of keywords is leaning more towards phrase structure, and a single word structure and the majority of keywords are selected from the titles and abstracts. The authors' familiarity with the thesauri and controlled tools causes homogeneity in assigning keywords and also provides more precise, faster, and easier retrieval of the keywords. It's suggested that a mixture of natural and control languages to be used in this database in order to reach more comprehensive results.

  17. Relationship between cardio-ankle vascular index and N-terminal pro-brain natriuretic peptide in hypertension and coronary heart disease subjects.

    Science.gov (United States)

    Wang, Hongyu; Liu, Jinbo; Zhao, Hongwei; Zhou, Yingyan; Zhao, Xujing; Song, Yuejie; Li, Lihong; Shi, Hongyan

    2014-09-01

    Arterial stiffness is an independent predictor for vascular diseases. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a strong prognostic marker in advanced stage of coronary heart disease (CHD). In the present study, we investigated the relationship between CAVI and NT-proBNP in hypertension and CHD subjects. Five hundred one subjects (male/female, 209/292) from Vascular Medicine of Peking University Shougang Hospital were divided into four groups: healthy group (n = 186), hypertension group (n = 159), CHD group (n = 45), and hypertension with CHD group (n = 111). CAVI was measured using VS-1000 apparatus. Our results showed that CAVI was significantly higher in hypertension subjects with CHD than in healthy and hypertension group, respectively (8.42 ± 1.51 vs. 7.77 ± 1.19; 8.42 ± 1.51 vs. 7.92 ± 1.11; both P vascular-related diseases. Crown Copyright © 2014. Published by Elsevier Inc. All rights reserved.

  18. The impact of visceral adipose tissue and high-molecular weight adiponectin on cardio-ankle vascular index in asymptomatic Japanese subjects.

    Science.gov (United States)

    Ohashi, Norihiko; Ito, Chikako; Fujikawa, Rumi; Yamamoto, Hideya; Kihara, Yasuki; Kohno, Nobuoki

    2009-07-01

    Few studies addressed the relation of visceral adiposity and high-molecular weight (HMW) adiponectin to arterial stiffness. We investigated the impact of visceral adipose tissue (VAT) and HMW adiponectin on cardio-ankle vascular index (CAVI) in asymptomatic Japanese subjects. We studied 487 consecutive subjects (271 men and 216 women) who underwent general health examination between October 2005 and May 2008. The abdominal, visceral, and subcutaneous adipose tissue areas were determined by low-dose x-ray computed tomography. Serum levels of total and HMW adiponectin were measured using the enzyme-linked immunosorbent assay system based on a monoclonal antibody to humans. Cardio-ankle vascular index was positively correlated with VAT area and negatively correlated with HMW adiponectin levels. We also found the positive association of the number of metabolic syndrome components with CAVI in both sexes. A stepwise multiple regression analysis revealed that age, VAT area, serum HMW adiponectin levels, and homeostasis model assessment of insulin resistance were independent determinants of CAVI. Receiver operating characteristic analyses demonstrated that the predictive value of the VAT area for the extent of CAVI (mild: 75th percentile) exceeded that of total or HMW adiponectin levels in both sexes. In conclusion, increased CAVI is associated with both amounts of VAT measured by computed tomography and serum HMW adiponectin levels in asymptomatic Japanese subjects. Receiver operating characteristic analysis indicates that the VAT area is a lot better predictor of arterial stiffness than adiponectin levels.

  19. Genome-wide association study of Lp-PLA(2 activity and mass in the Framingham Heart Study.

    Directory of Open Access Journals (Sweden)

    Sunil Suchindran

    2010-04-01

    Full Text Available Lipoprotein-associated phospholipase A(2 (Lp-PLA(2 is an emerging risk factor and therapeutic target for cardiovascular disease. The activity and mass of this enzyme are heritable traits, but major genetic determinants have not been explored in a systematic, genome-wide fashion. We carried out a genome-wide association study of Lp-PLA(2 activity and mass in 6,668 Caucasian subjects from the population-based Framingham Heart Study. Clinical data and genotypes from the Affymetrix 550K SNP array were obtained from the open-access Framingham SHARe project. Each polymorphism that passed quality control was tested for associations with Lp-PLA(2 activity and mass using linear mixed models implemented in the R statistical package, accounting for familial correlations, and controlling for age, sex, smoking, lipid-lowering-medication use, and cohort. For Lp-PLA(2 activity, polymorphisms at four independent loci reached genome-wide significance, including the APOE/APOC1 region on chromosome 19 (p = 6 x 10(-24; CELSR2/PSRC1 on chromosome 1 (p = 3 x 10(-15; SCARB1 on chromosome 12 (p = 1x10(-8 and ZNF259/BUD13 in the APOA5/APOA1 gene region on chromosome 11 (p = 4 x 10(-8. All of these remained significant after accounting for associations with LDL cholesterol, HDL cholesterol, or triglycerides. For Lp-PLA(2 mass, 12 SNPs achieved genome-wide significance, all clustering in a region on chromosome 6p12.3 near the PLA2G7 gene. Our analyses demonstrate that genetic polymorphisms may contribute to inter-individual variation in Lp-PLA(2 activity and mass.

  20. Sparse Adaptive Channel Estimation Based on lp-Norm-Penalized Affine Projection Algorithm

    OpenAIRE

    Yingsong Li; Wenxing Li; Wenhua Yu; Jian Wan; Zhiwei Li

    2014-01-01

    We propose an lp-norm-penalized affine projection algorithm (LP-APA) for broadband multipath adaptive channel estimations. The proposed LP-APA is realized by incorporating an lp-norm into the cost function of the conventional affine projection algorithm (APA) to exploit the sparsity property of the broadband wireless multipath channel, by which the convergence speed and steady-state performance of the APA are significantly improved. The implementation of the LP-APA is equivalent to adding a z...

  1. Characterization of human high-density lipoprotein subclasses LP A-I and LP A-I/A-II and binding to HepG2 cells

    NARCIS (Netherlands)

    E.P.C. Kilsdonk (Liesbeth); T. van Gent (Teus); A. van Tol (Arie)

    1990-01-01

    markdownabstractAbstract Plasma HDL can be classified according to their apolipoprotein content into at least two types of lipoprotein particles: lipoproteins containing both apo A-I and apo A-II (LP A-I/A-II) and lipoproteins with apo A-I but without apo A-II (LP A-I). LP A-I and LP A-I/A-II

  2. The combined effect of subjective body image and body mass index (distorted body weight perception) on suicidal ideation.

    Science.gov (United States)

    Shin, Jaeyong; Choi, Young; Han, Kyu-Tae; Cheon, Sung-Youn; Kim, Jae-Hyun; Lee, Sang Gyu; Park, Eun-Cheol

    2015-03-01

    Mental health disorders and suicide are an important and growing public health concern in Korea. Evidence has shown that both globally and in Korea, obesity is associated with an increased risk of developing some psychiatric disorders. Therefore, we examined the association between distorted body weight perception (BWP) and suicidal ideation. Data were obtained from the 2007-2012 Korea National Health and Nutritional Evaluation Survey (KNHANES), an annual cross-sectional nationwide survey that included 14 276 men and 19 428 women. Multiple logistic regression analyses were conducted to investigate the associations between nine BWP categories, which combined body image (BI) and body mass index (BMI) categories, and suicidal ideation. Moreover, the fitness of our models was verified using the Akaike information criterion. Consistent with previous studies, suicidal ideation was associated with marital status, household income, education level, and perceived health status in both genders. Only women were significantly more likely to have distorted BWP; there was no relationship among men. In category B1 (low BMI and normal BI), women (odds ratio [OR], 2.25; 95% confidence interval [CI], 1.48 to 3.42) were more likely to express suicidal ideation than women in category B2 (normal BMI and normal BI) were. Women in overweight BWP category C2 (normal BMI and fat BI) also had an increased OR for suicidal ideation (OR, 2.25; 95% CI, 1.48 to 3.42). Those in normal BWP categories were not likely to have suicidal ideation. Among women in the underweight BWP categories, only the OR for those in category A2 (normal BMI and thin BI) was significant (OR, 1.34; 95% CI, 1.13 to 1.59). Distorted BWP should be considered an important factor in the prevention of suicide and for the improvement of mental health among Korean adults, especially Korean women with distorted BWPs.

  3. The Combined Effect of Subjective Body Image and Body Mass Index (Distorted Body Weight Perception on Suicidal Ideation

    Directory of Open Access Journals (Sweden)

    Jaeyong Shin

    2015-03-01

    Full Text Available Objectives: Mental health disorders and suicide are an important and growing public health concern in Korea. Evidence has shown that both globally and in Korea, obesity is associated with an increased risk of developing some psychiatric disorders. Therefore, we examined the association between distorted body weight perception (BWP and suicidal ideation. Methods: Data were obtained from the 2007-2012 Korea National Health and Nutritional Evaluation Survey (KNHANES, an annual cross-sectional nationwide survey that included 14 276 men and 19 428 women. Multiple logistic regression analyses were conducted to investigate the associations between nine BWP categories, which combined body image (BI and body mass index (BMI categories, and suicidal ideation. Moreover, the fitness of our models was verified using the Akaike information criterion. Results: Consistent with previous studies, suicidal ideation was associated with marital status, household income, education level, and perceived health status in both genders. Only women were significantly more likely to have distorted BWP; there was no relationship among men. In category B1 (low BMI and normal BI, women (odds ratio [OR], 2.25; 95% confidence interval [CI], 1.48 to 3.42 were more likely to express suicidal ideation than women in category B2 (normal BMI and normal BI were. Women in overweight BWP category C2 (normal BMI and fat BI also had an increased OR for suicidal ideation (OR, 2.25; 95% CI, 1.48 to 3.42. Those in normal BWP categories were not likely to have suicidal ideation. Among women in the underweight BWP categories, only the OR for those in category A2 (normal BMI and thin BI was significant (OR, 1.34; 95% CI, 1.13 to 1.59. Conclusions: Distorted BWP should be considered an important factor in the prevention of suicide and for the improvement of mental health among Korean adults, especially Korean women with distorted BWPs.

  4. Optimized design method for trench-assisted grade-index ring-core fiber with low DMD and large Aeff

    Science.gov (United States)

    Qiao, Xihui; Tu, Jiajing; Long, Keping

    2017-02-01

    We propose a kind of trench-assisted graded-index ring-core fiber (TA-GI-RCF) with a low refractive index rod deployed in the center of the core, which supports three LP modes (LP01, LP11 and LP21) transmission. There are two difficulties about designing TA-GI-RCF, one is to depart LP21 mode from LP02 mode because their effective indices are too close which makes it difficult to realize only three LP modes transmission; the other one is how to make sure these three LP modes reach the receiver end with low differential mode delay (DMD), so that the computation complexity of multi-input multi-output (MIMO) digital signal process (DSP) can be reduced. At first, we realize the separation of LP21 mode and LP02 mode in TA-GI-RCF by enlarging the size of low refractive index rod. We next investigate the influence of the TA-GI-RCF structural parameters on DMD and DMD slope, and find that a graded-index core and a low refractive index rod can flexibly tune the DMD, and a trench can flexibly control the DMD slope. Through optimizing the core parameters, we find that the design region of α is 1.01 2.23 and that of Δ1 is 0.28% 0.46% at r1=30 μm, where α is the profile exponent and Δ1 is the relative refractive index difference between core and cladding. Simulation results show that TA-GI-RCF can achieve the effective area (Aeff) of LP01 mode over 2000 μm2 and the |DMD| between LP01 mode and LP11 mode is DMD over whole C+L band and large Aeff.

  5. Volume-dependent effect of supervised exercise training on fatty liver and visceral adiposity index in subjects with type 2 diabetes The Italian Diabetes Exercise Study (IDES).

    Science.gov (United States)

    Balducci, Stefano; Cardelli, Patrizia; Pugliese, Luca; D'Errico, Valeria; Haxhi, Jonida; Alessi, Elena; Iacobini, Carla; Menini, Stefano; Bollanti, Lucilla; Conti, Francesco G; Nicolucci, Antonio; Pugliese, Giuseppe

    2015-08-01

    This study evaluated the effect of supervised exercise training on liver enzymes and two surrogate measures of non-alcoholic fatty liver disease (NAFLD) in subjects with type 2 diabetes. Sedentary patients from 22 outpatient diabetes clinics were randomized by center, age and treatment to twice-a-week supervised aerobic and resistance training plus structured exercise counseling (exercise group, EXE; n=303) versus counseling alone (control group, CON; n=303) for 12 months. EXE participants were further randomized to low-to-moderate (n=142) or moderate-to-high (n=161) intensity training of equal energy cost. Baseline and end-of-study levels of liver enzymes, fatty liver index (FLI) and visceral adiposity index (VAI) were obtained. Enzyme levels did not change, whereas FLI and VAI decreased significantly in EXE, but not CON participants. Physical activity (PA) volume was an independent predictor of both FLI and VAI reductions, the extent of which increased from the 1st to the 4th quintile of PA volume and baseline to end-of-study changes in fitness parameters. Differences in the effect of LI versus HI training were negligible. Data from this large cohort of subjects with type 2 diabetes indicate that FLI and VAI decrease with supervised training in a volume-dependent manner. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  6. Quality Control of Motor Unit Number Index (MUNIX) Measurements in 6 Muscles in a Single-Subject "Round-Robin" Setup.

    Science.gov (United States)

    Neuwirth, Christoph; Burkhardt, Christian; Alix, James; Castro, José; de Carvalho, Mamede; Gawel, Malgorzata; Goedee, Stephan; Grosskreutz, Julian; Lenglet, Timothée; Moglia, Cristina; Omer, Taha; Schrooten, Maarten; Weber, Markus

    2016-01-01

    Motor Unit Number Index (MUNIX) is a neurophysiological measure that provides an index of the number of lower motor neurons in a muscle. Its performance across centres in healthy subjects and patients with Amyotrophic Lateral Sclerosis (ALS) has been established, but inter-rater variability between multiple raters in one single subject has not been investigated. To assess reliability in a set of 6 muscles in a single subject among 12 examiners (6 experienced with MUNIX, 6 less experienced) and to determine variables associated with variability of measurements. Twelve raters applied MUNIX in six different muscles (abductor pollicis brevis (APB), abductor digiti minimi (ADM), biceps brachii (BB), tibialis anterior (TA), extensor dig. brevis (EDB), abductor hallucis (AH)) twice in one single volunteer on consecutive days. All raters visited at least one training course prior to measurements. Intra- and inter-rater variability as determined by the coefficient of variation (COV) between different raters and their levels of experience with MUNIX were compared. Mean intra-rater COV of MUNIX was 14.0% (±6.4) ranging from 5.8 (APB) to 30.3% (EDB). Mean inter-rater COV was 18.1 (±5.4) ranging from 8.0 (BB) to 31.7 (AH). No significant differences of variability between experienced and less experienced raters were detected. We provide evidence that quality control for neurophysiological methods can be performed with similar standards as in laboratory medicine. Intra- and inter-rater variability of MUNIX is muscle-dependent and mainly below 20%. Experienced neurophysiologists can easily adopt MUNIX and adequate teaching ensures reliable utilization of this method.

  7. Beneficial effect of a weight-stable, low-fat/low-saturated fat/low-glycaemic index diet to reduce liver fat in older subjects.

    Science.gov (United States)

    Utzschneider, Kristina M; Bayer-Carter, Jennifer L; Arbuckle, Matthew D; Tidwell, Jaime M; Richards, Todd L; Craft, Suzanne

    2013-03-28

    Non-alcoholic fatty liver disease is associated with insulin resistance and dyslipidaemia and can progress to steatohepatitis and cirrhosis. We sought to determine whether dietary fat and saturated fat content alter liver fat in the absence of weight change in an older population. Liver fat was quantified by magnetic resonance spectroscopy before and after 4 weeks on an isoenergetic low-fat/low-saturated fat/low-glycaemic index (LGI) (LSAT: 23 % fat/7 % saturated fat/GI 70) diet in older subjects. In the present study, twenty subjects (seven males/thirteen females; age 69.3 (SEM 1.6) years, BMI 26.9 (SEM 0.8) kg/m2) were randomised to the LSAT diet and fifteen subjects (six males/nine females; age 68.6 (SEM 1.8) years, BMI 28.1 (SEM 0.9) kg/m2) to the HSAT diet. Weight remained stable. Liver fat decreased significantly on the LSAT diet (median 2.2 (interquartile range (IQR) 3.1) to 1.7 (IQR 1.8) %, P= 0.002) but did not change on the HSAT diet (median 1.2 (IQR 4.1) to 1.6 (IQR 3.9) %). The LSAT diet lowered fasting glucose and total cholesterol, HDL-cholesterol and LDL-cholesterol and raised TAG (Pdiet had no effect on glucose or HDL-cholesterol but increased total cholesterol and LDL-cholesterol (Pdiet, but the Matsuda index of insulin sensitivity improved on the LSAT diet (Pdiet was a predictor of changes in lipid parameters but not liver fat. We conclude that diet composition may be an important factor in the accumulation of liver fat, with a low-fat/low-saturated fat/LGI diet being beneficial.

  8. Improvement of the omega 3 index of healthy subjects does not alter the effects of dietary saturated fats or n-6PUFA on LDL profiles.

    Science.gov (United States)

    Dias, Cintia B; Amigó, Núria; Wood, Lisa G; Mallol, Roger; Correig, Xavier; Garg, Manohar L

    2017-03-01

    Dietary fat composition is known to modulate circulating lipid and lipoprotein levels. Although supplementation with long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) has been shown to reduce plasma triglyceride levels, the effect of the interactions between LCn-3PUFA and the major dietary fats consumed has not been previously investigated. In a randomized controlled parallel design clinical intervention, we examined the effect of diets rich in either saturated fatty acids (SFA) or omega-6 polyunsaturated fatty acids (n-6PUFA) on plasma lipid levels and lipoprotein profiles (lipoprotein size, concentration and distribution in subclasses) in subjects with an adequate omega 3 index. Twenty six healthy subjects went through a four-week pre-supplementation period with LCn-3PUFA and were then randomized to diets rich in either n-6PUFA or SFA both supplemented with LCn-3PUFA. The diet rich in n-6PUFA decreased low density lipoprotein (LDL) particle concentration (-8%, p=0.013) and LDL cholesterol (LDL-C) level (-8%, p=0.021), while the saturated fat rich diet did not affect LDL particle concentration or LDL-C levels significantly. Nevertheless, dietary saturated fatty acids increased LCn-3PUFA in plasma and tissue lipids compared with n-6PUFA, potentially reducing other cardiovascular risk factors such as inflammation and clotting tendency. Improvement on the omega 3 index of healthy subjects did not alter the known effects of dietary saturated fats and n-6PUFA on LDL profiles. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Comparison of myocardial performance index obtained either by conventional echocardiography or tissue Doppler echocardiography in healthy subjects and patients with heart failure.

    Science.gov (United States)

    Duzenli, Mehmet Akif; Ozdemir, Kurtulus; Aygul, Nazif; Soylu, Ahmet; Aygul, Meryem Ulku; Gök, Hasan

    2009-01-01

    This study was planned to investigate the normal reference values of myocardial performance index (MPI) obtained by tissue Doppler echocardiography (TDE) and the agreement between MPI measured by TDE and conventional MPI measured by pulsed-wave Doppler (PWD) in healthy subjects and patients with heart failure (HF). Two hundred and three patients with HF and 190 healthy subjects were enrolled in this study. Isovolumic contraction and relaxation time (ICT and IRT) and ejection time (ET) were measured from mitral inflow and left ventricular (LV) outflow. Tissue Doppler echocardiography recordings were obtained at the septal, lateral, inferior, and anterior of the mitral annulus and same time intervals were measured. Myocardial performance index was calculated. The functional capacity of the patients with HF was determined according to New York Heart Association classification. TDE-MPI values were higher than conventional PWD-MPI values in both groups (53%+/-8% vs 48%+/-11%, P<0.0001 in the healthy subjects; 84%+/-21% vs 72%+/-19%, P<0.0001 in the patients with HF). Moderate agreement was found between PWD-MPI and LV mean TDE-MPI in both groups. In identifying patients with moderately or severely decreased LV ejection fraction, TDE-MPI had higher cutoff values than conventional PWD-MPI, and TDE-MPI had higher specificity, sensitivity, negative predictive value, and diagnostic accuracy. In patients with HF, TDE-MPI had a stronger correlation with LV ejection fraction and functional capacity than did PWD-MPI. TDE-MPI is an alternative to conventional PWD-MPI in assessment of cardiac function. However, the higher MPI cutoff points should be considered when this method is used for the evaluation of cardiac function.

  10. The Association of Unintentional Changes in Weight, Body Composition, and Homeostasis Model Assessment Index with Glycemic Progression in Non-Diabetic Healthy Subjects

    Directory of Open Access Journals (Sweden)

    Eun-Jung Rhee

    2011-04-01

    Full Text Available BackgroundWe performed a retrospective longitudinal study on the effects of changes in weight, body composition, and homeostasis model assessment (HOMA indices on glycemic progression in subjects without diabetes during a four-year follow-up period in a community cohort without intentional intervention.MethodsFrom 28,440 non-diabetic subjects who participated in a medical check-up program in 2004, data on anthropometric and metabolic parameters were obtained after four years in 2008. Body composition analyses were performed with a bioelectrical impedance analyzer. Skeletal muscle index (SMI, % was calculated with lean mass/weight×100. Subjects were divided into three groups according to weight change status in four years: weight loss (≤-5.0%, stable weight (-5.0 to 5.0%, weight gain (≥5.0%. Progressors were defined as the subjects who progressed to impaired fasting glucose or diabetes.ResultsProgressors showed worse baseline metabolic profiles compared with non-progressors. In logistic regression analyses, the increase in changes of HOMA-insulin resistance (HOMA-IR in four years presented higher odds ratios for glycemic progression compared with other changes during that period. Among the components of body composition, a change in waist-hip ratio was the strongest predictor, and SMI change in four years was a significant negative predictor for glycemic progression. Changes in HOMA β-cell function in four years was a negative predictor for glycemic progression.ConclusionIncreased interval changes in HOMA-IR, weight gain and waist-hip ratio was associated with glycemic progression during a four-year period without intentional intervention in non-diabetic Korean subjects.

  11. Comparison of Physiological and Psychological Relaxation Using Measurements of Heart Rate Variability, Prefrontal Cortex Activity, and Subjective Indexes after Completing Tasks with and without Foliage Plants.

    Science.gov (United States)

    Park, Sin-Ae; Song, Chorong; Oh, Yun-Ah; Miyazaki, Yoshifumi; Son, Ki-Cheol

    2017-09-20

    The objective of this study was to compare physiological and psychological relaxation by assessing heart rate variability (HRV), prefrontal cortex activity, and subjective indexes while subjects performed a task with and without foliage plants. In a crossover experimental design, 24 university students performed a task transferring pots with and without a foliage plant for 3 min. HRV and oxyhemoglobin (oxy-Hb) concentration in the prefrontal cortex were continuously measured. Immediately thereafter, subjective evaluation of emotions was performed using a modified semantic differential (SD) method and a profile of mood state questionnaire (POMS). Results showed that the natural logarithmic (ln) ratio of low frequency/high frequency, as an estimate of sympathetic nerve activity, was significantly lower while performing the task with foliage plants for the average 3 min measurement interval. Oxy-Hb concentration in the left prefrontal cortex showed a tendency to decrease in the 2-3 min interval in the task with foliage plants compared to the task without plants. Moreover, significant psychological relaxation according to POMS score and SD was demonstrated when the task involved foliage plants. In conclusion, the task involving foliage plants led to more physiological and psychological relaxation compared with the task without foliage plants.

  12. Cardiac output and cardiac index measured with cardiovascular magnetic resonance in healthy subjects, elite athletes and patients with congestive heart failure

    Directory of Open Access Journals (Sweden)

    Carlsson Marcus

    2012-07-01

    Full Text Available Abstract Background Cardiovascular Magnetic Resonance (CMR enables non-invasive quantification of cardiac output (CO and thereby cardiac index (CI, CO indexed to body surface area. The aim of this study was to establish if CI decreases with age and compare the values to CI for athletes and for patients with congestive heart failure (CHF. Methods CI was measured in 144 healthy volunteers (39 ± 16 years, range 21–81 years, 68 females, in 60 athletes (29 ± 6 years, 30 females and in 157 CHF patients with ejection fraction (EF below 40% (60 ± 13 years, 33 females. CI was calculated using aortic flow by velocity-encoded CMR and is presented as mean ± SD. Flow was validated in vitro using a flow phantom and in 25 subjects with aorta and pulmonary flow measurements. Results There was a slight decrease of CI with age in healthy subjects (8 ml/min/m2 per year, r2 = 0.07, p = 0.001. CI in males (3.2 ± 0.5 l/min/m2 and females (3.1 ± 0.4 l/min/m2 did not differ (p = 0.64. The mean ± SD of CI in healthy subjects in the age range of 20–29 was 3.3 ± 0.4 l/min/m2, in 30–39 years 3.3 ± 0.5 l/min/m2, in 40–49 years 3.1 ± 0.5 l/min/m2, 50–59 years 3.0 ± 0.4 l/min/m2 and >60 years 3.0 ± 0.4 l/min/m2. There was no difference in CI between athletes and age-controlled healthy subjects but HR was lower and indexed SV higher in athletes. CI in CHF patients (2.3 ± 0.6 l/min/m2 was lower compared to the healthy population (p 2 = 0.07, p  Conclusions CI decreases in healthy subjects with age but does not differ between males and females. We found no difference in CI between athletes and healthy subjects at rest but CI was lower in patients with congestive heart failure. The presented values can be used as reference values for flow velocity mapping CMR.

  13. Association between the Postprandial Glucose Levels and Arterial Stiffness Measured According to the Cardio-ankle Vascular Index in Non-diabetic Subjects.

    Science.gov (United States)

    Tsuboi, Atsuko; Ito, Chikako; Fujikawa, Rumi; Yamamoto, Hideya; Kihara, Yasuki

    2015-01-01

    Although a relationship between post-challenge hyperglycemia and arterial stiffness has been reported, the relationship between the postprandial glucose levels and cardio-ankle vascular index (CAVI) in non-diabetic subjects is not clear. This study thus evaluated the association between the postprandial glucose levels after a composite meal and the degree of arterial stiffness measured according to CAVI in non-diabetic subjects. The subjects included 1,291 individuals (655 men and 636 women; mean age, 48.6 years; range, 23-85 years) who underwent medical examinations, including blood tests and CAVI assessments, between October 2005 and April 2012. The 1-hour postprandial glucose levels were determined after a 600-kcal traditional Japanese meal. The CAVI values were significantly higher in the subjects with higher 1-hour postprandial glucose levels (≥140 mg/dL in men; ≥158 mg/dL in women). A simple regression analysis indicated that the CAVI values were significantly correlated with the 1-hour postprandial glucose levels in men (r=0.286, pblood pressure, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, 1-hour postprandial glucose, homeostatis model assessment of insulin resistance, estimated glemerular filtration rate, and high sensitive C-reactive protein, stepwise multiple regression analysis demonstrated that the 1-hour postprandial glucose level was an independent predictor associated with the CAVI in men (p=0.003) and older women 50 years of age or older (p=0.003). This study demonstrated that the 1-hour postprandial glucose levels are associated with increased CAVI values in non-diabetic men and older women 50 years of age or older.

  14. Effect of high and low glycemic index breakfast on postprandial metabolic parameters and satiety in subjects with type 2 diabetes mellitus under intensive insulin therapy: Controlled clinical trial.

    Science.gov (United States)

    Lobos, Daniela R; Vicuña, Isabella A; Novik, Victoria; Vega, Claudia A

    2017-08-01

    The results of studies evaluating the metabolic effects of glycemic index (GI) in subjects with type 2 diabetes mellitus (DM2) have been contradictory. Consequently, the benefits of its application are controversial and polarized opinions of international organizations have been disclosed. The above situation leads this study to evaluate the acute effect of low and high GI breakfast on the glycemic response and satiety in subjects with DM2 under intensive insulin therapy (IIT). A controlled, crossover and single-blind clinical trial was developed involving 10 obese subjects with DM2 under IIT, with a period of at least six months under IIT and with fast insulin prescription before breakfast. Subjects ingested on two different occasions a high or low GI breakfast. In both stages, glycemia was evaluated at 0 (basal), 30, 60 and 120 min, and satiety and satiation were evaluated through a visual analogue scale. In contrast to high GI breakfast, the low GI meal generated a significant decrease of 46% for the area under the curve of glucose (Δ 1940 mg/dL × 120 min, p = 0.022) and in mean glycemia evaluated at 30, 60 and 120 min. Moreover, in the low GI stage 8 of 10 patients achieved a 2 h postprandial glycemia lower than 180 mg/dL, without statistical significance. A nonsignificant increase of 12.7% (Δ 1.06 cm, p = 0.271) in satiety at 120 min in the low GI stage was observed. In contrast to high GI breakfast, the low GI breakfast generated a significantly lower glycemic response. This assay allowed for the contribution of more in depth nutritional recommendations for this group of patients. Registered under ClinicalTrials.gov Identifier no. NCT02881164. Copyright © 2017 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.

  15. The potential of the Global Person Generated Index for evaluating the perceived impacts of conservation interventions on subjective well-being

    DEFF Research Database (Denmark)

    Rasolofoson, Ranaivo Andriarilala; Nielsen, Martin Reinhardt; Jones, Julia P.G.

    2018-01-01

    There is growing interest in the importance of ensuring that biodiversity conservation is not achieved at the expense of local people’s well-being. It has been suggested that when evaluating the impact of an intervention, the affected population should be allowed to define well-being (requiring...... a subjective measure), and impacts (requiring a participatory approach), but very few, if any, conservation evaluations live up to these standards. We used a participatory impact evaluation approach with the Global Person Generated Index (GPGI) to investigate the relative impacts of strict protection......, and the relative importance of the five identified domains. Participatory impact evaluation establishes local perceptions of the cause-effect relationship between an intervention and respondents’ performance in each domain. Over half the respondents perceived no positive or negative impacts from the conservation...

  16. Fire Service Training. LP and Compressed Gas Emergencies.

    Science.gov (United States)

    North Carolina State Dept. of Community Colleges, Raleigh.

    Part of a series of instructional outlines intended for use in a training program for firemen with no previous formal training, this curriculum guide discusses safety precautions for liquefied petroleum (LP) and compressed gas emergencies. During its twelve hours of instruction it covers (1) terminology; (2) the chemical composition of the gases;…

  17. 2-Summing operators on C([0,1],lp)

    Indian Academy of Sciences (India)

    In this paper, in case s = 2, we give necessary and sufficient conditions that natural operators on C([0, 1],lp) with values in l1 satisfies (α), (β) and (γ), which show that the above implication is the best possible result. Keywords. Banach spaces of continuous functions; tensor products; operator ideals; p-summing operators. 1.

  18. Optimization of lipase production by Staphylococcus sp. Lp12 ...

    African Journals Online (AJOL)

    A bacterial strain isolated from an oil contaminated soil, identified as Staphylococcus sp. Lp12 was screened for lipase activity on tributyrin agar and spirit blue agar medium. Maximum lipase production was observed at 48 h of growth (3.5 Eu/ml). Peptone was found to be as an ideal nitrogen source for production at a ...

  19. Prediabetes Exhibits Decreased Disposition Index Correlated with Deterioration of Glycemic Parameters in Nonobese Japanese Subjects: A Cross-Sectional Study from Medical Examination.

    Science.gov (United States)

    Takeda, Yasutaka; Fujita, Yukihiro; Yanagimachi, Tsuyoshi; Honjo, Jun; Abiko, Atsuko; Asai, Mahito; Haneda, Masakazu

    2017-08-01

    Prediabetes, defined as impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), likely develops to type 2 diabetes mellitus (DM) and independently increases cardiovascular risk. We employed disposition index (DI), a new metabolic parameter indicating the pancreatic beta cell function adjusted for insulin resistance, and investigated whether it could be altered in Japanese population with prediabetes and associated with early glucose intolerance. A total of 102 adults who underwent an oral glucose tolerance test at the medical screening were designated to normal glucose tolerance (NGT), IFG, IGT, and DM. We calculated insulinogenic index (IGI) and homeostasis model assessment (HOMA) of β cell function (HOMA-β) as insulin secretory function, HOMA-insulin resistance (HOMA-IR), and quantitative insulin sensitivity check index (QUICKI) as insulin resistance and DI, and assessed correlations between these indices and glycemic parameters. We observed graded increase of glycemic parameters in the order of NGT, IFG, IGT, and DM. HOMA-IR was significantly higher only in DM compared with NGT, although HOMA-β, IGI, and QUICKI showed no significant differences among the groups. In contrast, DI was significantly lower in IFG, IGT, and DM compared with NGT. In correlation analysis, glycemic parameters related positively to HOMA-IR, but inversely to DI. Only two parameters, IGI and particularly DI, were significantly decreased in the subjects with 1-hr postload glucose >8.6 mmol/L previously proposed as a predictor of type 2 diabetes. Our results suggest that reduction of DI promptly reflects the alteration of early glucose intolerance in Japanese population presenting with prediabetes.

  20. Proceedings (Mathematical Sciences) SUBJECT INDEX

    Indian Academy of Sciences (India)

    Sobolev spaces associated to the harmonic oscillator. 337. Hilbert matrix. Inequalities involving upper bounds for certain matrix operators. 325. Hilbert modules. Generalized unitaries and the Picard group. 429. Hilbert space. On Nyman, Beurling and Baez-Duarte's. Hilbert space reformulation of the Rie- mann hypothesis.

  1. Proceedings (Mathematical Sciences) SUBJECT INDEX

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    perforated domain with Dirichlet boundary condition. 425. Deformed sphere. Stokes flow with slip and Kuwabara bound- ary conditions. 463. Degree of a map. Two-dimensional weak pseudomanifolds on eight vertices. 257. δM -invariant. A basic inequality for submanifolds in locally conformal almost cosymplectic manifolds.

  2. Proceedings (Mathematical Sciences) SUBJECT INDEX

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    Some approximation theorems. 87. Automorphic form. Reduction theory for a rational function field. 153. Banach algebra. Questions concerning matrix algebras and ... Euler–Maclaurin summation formula. Analogues of Euler and Poisson summa- tion formulae. 213. Exponential energy decay. Uniform stability of damped ...

  3. Proceedings (Mathematical Sciences) SUBJECT INDEX

    Indian Academy of Sciences (India)

    Abelian groups. A variant of Davenport's constant. 147. Additive mapping. On the stability of Jensen's functional equation on groups. 31. Analytic functions. On Eneström–Kakeya theorem and related analytic functions. 359. A-net. On the problem of isometry of a hypersur- face preserving mean curvature. 49. Arithmetical ...

  4. Proceedings (Mathematical Sciences) SUBJECT INDEX

    Indian Academy of Sciences (India)

    67. Explicit formula. Large time behaviour of solutions of a sys- tem of generalized Burgers equation 509. Extension spaces. Fixed point theory for composite maps on almost dominating extension spaces 339. Fatou property. Basic topological and geometric properties of Ces`aro–Orlicz spaces. 461. Finite amplitude motions.

  5. Proceedings (Mathematical Sciences) SUBJECT INDEX

    Indian Academy of Sciences (India)

    New inequalities for the Hurwitz zeta func- tion. 495. Dirichlet problem. On existence and stability of solutions for higher order semilinear Dirichlet problems. 627. Discrete approximation. Approximation of quantum Lévy processes by quantum random walks. 281. Distance condition. Decomposition and removability proper-.

  6. Proceedings (Mathematical Sciences) SUBJECT INDEX

    Indian Academy of Sciences (India)

    metric sums. 411. Asymptotics. A further note on the force discrepancy for wing theory in Euler flow. 679. Atkin–Lehner theory. Orthogonality and Hecke operators .... synectic lift of a Riemannian metric 345. Injective tensor products. Riesz isomorphisms of tensor products of order unit Banach spaces. 383. Integral transforms.

  7. Subject Index 1207..1226

    Indian Academy of Sciences (India)

    Dry heat. Response surface method applied to optimization of estradiol permeation in chitosan membranes. 481. DTA/TG. Synthesis and luminescence properties of BaTiO3:RE (RE = Gd3+, Dy3+, Tb3+, Lu3+) phosphors. 1011. Duplex stainless steel. Effect of rolling deformation and solution treatment on microstructure and ...

  8. Proceedings (Mathematical Sciences) SUBJECT INDEX

    Indian Academy of Sciences (India)

    C*-enveloping algebra. Topological *-algebras with C*-enveloping algebras II. 65. Calderón–Lozanowski space. On property (β) in Banach lattices, Calderón–. Lozanowskii and Orlicz–Lorentz spaces. 319. Caratheodory function. Periodic and boundary value problems for second order differential equations. 107. Character.

  9. Hjælp til selvcensur

    DEFF Research Database (Denmark)

    Plessis, Erik Mygind du

    2016-01-01

    This paper seeks to explain silence in the workplace through an analytical perspective derived from Judith Butlers work on censorship, and in this way suggest an alternative to explanations in the existing literature on employee silence, which are often tied to the actions and motivations...... of the individual subject. It is thus argued that self-help books can be seen as indicative of a pervasive culture of self-improvement, which among other things promotes the absence of criticism in the workplace. The empirical point of departure for this argument is the two bestselling self-help books The secret...

  10. 75 FR 38514 - Application to Export Electric Energy; Brookfield Energy Marketing LP

    Science.gov (United States)

    2010-07-02

    ... Application to Export Electric Energy; Brookfield Energy Marketing LP AGENCY: Office of Electricity Delivery and Energy Reliability, DOE. ACTION: Notice of application. SUMMARY: Brookfield Energy Marketing LP... power marketing agencies and other entities within the United States. The existing international...

  11. Deregulation of LP gas industry and future problems; LP gas sangyo no kisei kanwa to kongo no kadai

    Energy Technology Data Exchange (ETDEWEB)

    Mori, T.; Okaya, Y.; Kaneko, Y. [The Institute of Energy Economics, Tokyo (Japan)

    1997-01-30

    This paper describes deregulation of LP gas industry and future problems. The conventional regulation in LP gas industry aims at the security of safety of LP gas and the proper business. The deregulation consists of the release of social regulation of safety and the reconsideration based on the introduction of competitive principle. The law was enforced from April, 1997. This law includes the proper response to advancement of safety technology, addition of self-safety incentive, open information to general consumers, and simplification of procedures. Safety and sales are separated through an establishment of safety organization. License system of sales is changed to registration system for easier participation. The current LP gas industry is loosing its competitive force due to its higher cost compared with the competitive fuels. The demand stays in a low level. There are a lot of small-scale retailers, and the enhancement of them is a problem. It is required to improve the productivity by the expansion of scale through cooperation and integration, to reduce the cost by rationalization through bulk supply and centralized monitoring, and to realize the diversification of management.

  12. Ambulatory Arterial Stiffness Index (AASI) is Unable to Estimate Arterial Stiffness of Hypertensive Subjects: Role of Nocturnal Dipping of Blood Pressure.

    Science.gov (United States)

    Di Raimondo, Domenico; Casuccio, Alessandra; Di Liberti, Rosangela; Musiari, Gaia; Zappulla, Valentina; D'Angelo, Alessandra; Pinto, Antonio

    2017-01-01

    Ambulatory Arterial Stiffness Index (AASI) has been proposed as an indirect and simpler method to estimate the Arterial Stiffness (AS). AASI, calculated from a set of data collected during a 24-hours ambulatory blood pressure monitoring (ABPM), is defined as 1 minus the regression slope of diastolic on systolic blood pressure (BP) values. For a given increase in diastolic BP, the increase in systolic BP is smaller in a compliant compared to a stiff artery; the stiffer the arterial tree, the closer AASI is to 1. AASI was demonstrated to predict cardiovascular mortality, cerebrovascular events and to be associated with target organ damage. Taking into account the almost complete absence of data regarding the ability of AASI to predict the different degree of AS when hypertensives are divided into four classes of dipping in relation to the extent of the nocturnal reduction of BP (extreme dippers, dippers, mild dippers and reverse dippers) aim to clarify the ability of AASI to estimate the different degree of AS of hypertensive subjects with different nocturnal BP profile and resulting in different extent of organ damage. We enrolled 816 subjects (403 men and 413 women) with essential hypertension, referred to the U.O.C of Medicina Interna e Cardioangiologia of the University of Palermo; 173 subjects (71 men and 102 women, mean age 44.4 ± 14.6 years) without a history of hypertension were enrolled as controls. The analysis of data was performed by dividing the population into four categories in relation to the extent of the nocturnal decline of BP: 124 extreme dipper (mean age 54,8 ± 12,4 years, men 46.8 %); 287 dipper (mean age 55,9 ± 14,2 years, men 54,0 %); 271 mild dipper (mean age 61,5 ± 14,7 years, men 52,0 %); 134 reverse dipper (mean age 61,5 ± 14,7 years, men 33.6 %). The mean value of AASI was significantly higher for mild and reverse dippers versus control patients and versus the other categories of dipping. The multiple regression analysis with AASI as

  13. Responsiveness and Minimal Important Changes of the Western Ontario and McMaster Universities Osteoarthritis Index in Subjects Undergoing Rehabilitation Following Hip Fracture.

    Science.gov (United States)

    Monticone, Marco; Ambrosini, Emilia; Secci, Claudio; Rocca, Barbara; Ferrante, Simona; Capone, Antonio

    2017-05-01

    To evaluate the responsiveness and minimal important changes (MICs) for the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and its subscales in subjects with hip fractures. At the beginning and end of a 2-month rehabilitation program, 106 patients completed the WOMAC. After the program, the global perceived effect (GPE) was analyzed to produce a dichotomous outcome (improved vs. stable). Responsiveness for the WOMAC and its subscales were calculated by distribution (effect size; standardized response mean) and anchor-based methods (receiver operating characteristic curves; correlations between change scores of the WOMAC and its subscales and GPE). Receiver operating characteristic curves were also used in order to compute the best cutoff levels between improved and stable subjects (MICs). The effect size ranged from 0.64 to 11.10 and the standardized response mean from 0.79 to 2.65. The receiver operating characteristic analyses revealed an MIC value (area under the curve, sensitivity, specificity) for the WOMAC of 29 (0.817, 92, 78); values of 35 (0.820, 77, 76) 44 (0.625, 25, 95), and 24 (0.707, 100, 76) were found for pain, stiffness, and physical function subscales, respectively. Correlations between change scores of the WOMAC and its subscales and GPE were low (0.240, for stiffness subscale) to moderate (0.438-0.570 for the other subscales and the WOMAC). The WOMAC and its subscales (all but stiffness) were sensitive in detecting clinical changes in subjects with hip fracture undergoing rehabilitation. We recommend taking the MICs provided into account when assessing patients' improvement or planning studies in this clinical context.

  14. Beneficial effect of a weight-stable, low-fat/low-saturated fat/low-glycaemic index diet to reduce liver fat in older subjects

    Science.gov (United States)

    Utzschneider, Kristina M.; Bayer-Carter, Jennifer L.; Arbuckle, Matthew D.; Tidwell, Jaime M.; Richards, Todd L.; Craft, Suzanne

    2014-01-01

    Non-alcoholic fatty liver disease is associated with insulin resistance and dyslipidaemia and can progress to steatohepatitis and cirrhosis. We sought to determine whether dietary fat and saturated fat content alter liver fat in the absence of weight change in an older population. Liver fat was quantified by magnetic resonance spectroscopy before and after 4 weeks on an isoenergetic low-fat/low-saturated fat/low-glycaemic index (LGI) (LSAT: 23% fat/7% saturated fat/GI fat/high-saturated fat/high-GI (HSAT: 43% fat/24% saturated fat/GI > 70) diet in older subjects. In the present study, twenty subjects (seven males/thirteen females; age 69·3 (sem 1·6) years, BMI 26·9 (sem 0·8) kg/m2) were randomised to the LSAT diet and fifteen subjects (six males/nine females; age 68·6 (sem 1·8) years, BMI 28·1 (sem 0·9) kg/m2) to the HSAT diet. Weight remained stable. Liver fat decreased significantly on the LSAT diet (median 2·2 (interquartile range (IQR) 3·1) to 1·7 (IQR 1·8) %, P=0·002) but did not change on the HSAT diet (median 1·2 (IQR 4·1) to 1·6 (IQR 3·9) %). The LSAT diet lowered fasting glucose and total cholesterol, HDL-cholesterol and LDL-cholesterol and raised TAG (Peffect on glucose or HDL-cholesterol but increased total cholesterol and LDL-cholesterol (Pfat. We conclude that diet composition may be an important factor in the accumulation of liver fat, with a low-fat/low-saturated fat/LGI diet being beneficial. PMID:22849970

  15. Changes in pulse rate, respiratory rate, blood oxygenation, perfusion index, skin conductance, and their variability induced during and after grounding human subjects for 40 minutes.

    Science.gov (United States)

    Chevalier, Gaetan

    2010-01-01

    Previous studies have shown that grounding produces quantifiable physiologic changes. This study was set up to reproduce and expand earlier electrophysiologic and physiologic parameters measured immediately after grounding with improved methodology and state-of-the-art equipment. A multiparameter double-blind experiment was conducted with 14 men and 14 women (age range: 18-80) in relatively good health. Subjects were screened for health problems using a commonly used health questionnaire. They were seated in a comfortable recliner and measured during 2-hour grounding sessions, leaving time for signals to stabilize before, during, and after grounding (40 minutes for each period). Sham 2-hour grounding sessions were also recorded with the same subjects as controls. This report presents results for 5 of the 18 parameters measured. The parameters reported here are: skin conductance (SC), blood oxygenation (BO), respiratory rate (RR), pulse rate (PR), and perfusion index (PI). This study was performed in a rented facility in Encinitas, California. The facility was chosen in a quiet area for its very low electromagnetic noise. For each session, statistical analyses were performed on four 10-minute segments: before and after grounding (sham grounding for control session) and before and after ungrounding (sham ungrounding). There was an immediate decrease in SC at grounding and an immediate increase at ungrounding on all subjects. RR increased during grounding, and the effect lasted after ungrounding. RR variance increased immediately after grounding then decreased. BO variance decreased during grounding, followed by a dramatic increase after ungrounding. PR and PI variances increased toward the end of the grounding period, and this change persisted after ungrounding. These results warrant further research to determine how grounding affects the body. Grounding could become important for relaxation, health maintenance and disease prevention.

  16. Body Mass Index and Mortality in the General Population and in Subjects with Chronic Disease in Korea: A Nationwide Cohort Study (2002-2010.

    Directory of Open Access Journals (Sweden)

    Nam Hoon Kim

    Full Text Available The association between body mass index (BMI and mortality is not conclusive, especially in East Asian populations. Furthermore, the association has been neither supported by recent data, nor assessed after controlling for weight changes.We evaluated the relationship between BMI and all-cause or cause-specific mortality, using prospective cohort data by the National Health Insurance Service in Korea, which consisted of more than one million subjects. A total of 153,484 Korean adults over 30 years of age without pre-existing cardiovascular disease or cancer at baseline were followed-up until 2010 (mean follow-up period = 7.91 ± 0.59 years. Study subjects repeatedly measured body weight 3.99 times, on average.During follow-up, 3,937 total deaths occurred; 557 deaths from cardiovascular disease, and 1,224 from cancer. In multiple-adjusted analyses, U-shaped associations were found between BMI and mortality from any cause, cardiovascular disease, and cancer after adjustment for age, sex, smoking status, alcohol consumption, physical activity, socioeconomic status, and weight change. Subjects with a BMI < 23 kg/m2 and ≥ 30 kg/m2 had higher risks of all-cause and cause-specific mortality compared with the reference group (BMI 23-24.9 kg/m2. The lowest risk of all-cause mortality was observed in subjects with a BMI of 25-26.4 kg/m2 (adjusted hazard ratio [HR] 0.86; 95% CI 0.77 to 0.97. In subgroup analyses, including the elderly and those with chronic diseases (diabetes mellitus, hypertension, and chronic kidney disease, subjects with a BMI of 25-29.9 kg/m2 (moderate obesity had a lower risk of mortality compared with the reference. However, this association has been attenuated in younger individuals, in those with higher socioeconomic status, and those without chronic diseases.Moderate obesity was associated more strongly with a lower risk of mortality than with normal, underweight, and overweight groups in the general population of South Korea

  17. Body image discrepancy and subjective norm as mediators and moderators of the relationship between body mass index and quality of life

    Science.gov (United States)

    Pétré, Benoit; Scheen, André J; Ziegler, Olivier; Donneau, Anne-Françoise; Dardenne, Nadia; Husson, Eddy; Albert, Adelin; Guillaume, Michèle

    2016-01-01

    Background and objective Despite the strength and consistency of the relationship between body mass index (BMI) and quality of life (QoL), a reduction in BMI does not necessarily lead to an improvement in QoL. Between-subject variability indicates the presence of mediators and moderators in the BMI–QoL association. This study aimed to examine the roles of body image discrepancy (BID) and subjective norm (SN) as potential mediators and moderators. Subjects and methods In 2012, 3,016 volunteers (aged ≥18 years) participated in a community-based survey conducted in the French-speaking region of Belgium. Participation was enhanced using a large multimedia campaign (which was supported by a large network of recruiters) that employed the nonstigmatizing slogan, “Whatever your weight, your opinion will count”. Participants were invited to complete a web-based questionnaire on their weight-related experiences. Self-reported measures were used to calculate each participant’s BMI, BID, SN, and QoL (a French obesity-specific QoL questionnaire was used to calculate the participants’ physical dimension of QoL scores [PHY-QoL], psychosocial dimension of QoL scores [PSY/SOC-QoL], and their total scores). The covariates included gender, age, subjective economic status, level of education, household size, and perceived health. The mediation/moderation tests were based on Hayes’ method. Results Tests showed that the relationships between BMI and PHY-QoL, PSY/SOC-QoL, and TOT-QoL were partially mediated by BID in both males and females and by SN in females. Moreover, BID was a moderator of the relationship between BMI and PSY/SOC-QoL in males and females. SN was a moderator of the relationship between BMI and PSY/SOC-QoL in males and between BMI and total scores in males (when used without BID in the models). Conclusion BID and SN should be considered as important factors in obesity management strategies. The study shows that targeting BMI only is not sufficient to

  18. Body image discrepancy and subjective norm as mediators and moderators of the relationship between body mass index and quality of life.

    Science.gov (United States)

    Pétré, Benoit; Scheen, André J; Ziegler, Olivier; Donneau, Anne-Françoise; Dardenne, Nadia; Husson, Eddy; Albert, Adelin; Guillaume, Michèle

    2016-01-01

    Despite the strength and consistency of the relationship between body mass index (BMI) and quality of life (QoL), a reduction in BMI does not necessarily lead to an improvement in QoL. Between-subject variability indicates the presence of mediators and moderators in the BMI-QoL association. This study aimed to examine the roles of body image discrepancy (BID) and subjective norm (SN) as potential mediators and moderators. In 2012, 3,016 volunteers (aged ≥18 years) participated in a community-based survey conducted in the French-speaking region of Belgium. Participation was enhanced using a large multimedia campaign (which was supported by a large network of recruiters) that employed the nonstigmatizing slogan, "Whatever your weight, your opinion will count". Participants were invited to complete a web-based questionnaire on their weight-related experiences. Self-reported measures were used to calculate each participant's BMI, BID, SN, and QoL (a French obesity-specific QoL questionnaire was used to calculate the participants' physical dimension of QoL scores [PHY-QoL], psychosocial dimension of QoL scores [PSY/SOC-QoL], and their total scores). The covariates included gender, age, subjective economic status, level of education, household size, and perceived health. The mediation/moderation tests were based on Hayes' method. Tests showed that the relationships between BMI and PHY-QoL, PSY/SOC-QoL, and TOT-QoL were partially mediated by BID in both males and females and by SN in females. Moreover, BID was a moderator of the relationship between BMI and PSY/SOC-QoL in males and females. SN was a moderator of the relationship between BMI and PSY/SOC-QoL in males and between BMI and total scores in males (when used without BID in the models). BID and SN should be considered as important factors in obesity management strategies. The study shows that targeting BMI only is not sufficient to improve the QoL of overweight and obese subjects, and that other variables

  19. Dual factor pulse pressure: body mass index and outcome in type 2 diabetic subjects on maintenance  hemodialysis. A longitudinal study 2003–2006

    Directory of Open Access Journals (Sweden)

    Lydia Foucan

    2008-12-01

    Full Text Available Lydia Foucan1,2, Kheira Hue3, Jocelyn Inamo1, Jacqueline Deloumeaux1,2, Anne Blanchet-Deverly, et al1Research group Clinical Epidemiology and Medicine of the University of Antilles and Guyane, French West Indies; 2Department of Medical Information and Public Health; 3Nephrology and hemodialysis Unit; 4Cardiology Unit, CHU of Pointe-à-Pitre, Guadeloupe, French West Indies; 5Hemodialysis Unit, Clinic of Choisy Sainte Anne, Guadeloupe, French West IndiesBackground: Inverse associations between risk factors and mortality have been reported in epidemiological studies of patients on maintenance hemodialysis (MHD.Objective: The aim of this prospective study was to estimate the effect of the dual variable pulse pressure (PP – body mass index (BMI on cardiovascular (CV events and death in type 2 diabetic (T2D subjects on MHD in a Caribbean population.Methods: Eighty Afro-Caribbean T2D patients on MHD were studied prospectively from 2003 to 2006. Proportional-hazard modeling was used.Results: Of all, 23.8% had a high PP (PP ≥ 75th percentile, 76.3% had BMI < 30 Kg/m2, 21.3% had the dual factor high PP – absence of obesity. During the study period, 23 patients died and 13 CV events occurred. In the presence of the dual variable and after adjustment for age, gender, duration of MHD, and pre-existing CV complications, the adjusted hazard ratio (HR (95% CI of CV events and death were respectively 2.7 (0.8–8.3; P = 0.09 and 2.4 (1.1–5.9; P = 0.04.Conclusions: The dual factor, high PP – absence of obesity, is a prognosis factor of outcome. In type 2 diabetics on MHD, a specific management strategy should be proposed in nonobese subjects with wide pulse pressure in order to decrease or prevent the incidence of fatal and nonfatal events.Keywords: dual factor, pulse pressure, body mass index, type 2 diabetes, outcome

  20. Bragg grating induced cladding mode coupling due to asymmetrical index modulation in depressed cladding fibers

    DEFF Research Database (Denmark)

    Berendt, Martin Ole; Grüne-Nielsen, Lars; Soccolich, C.F.

    1998-01-01

    UV-written Bragg gratings find wide spread use as wavelength selective components. In reflection high extinction ratios are routinely obtained. However, coupling to cladding modes gives excess loss on the short wavelength side of the main reflection. Different fiber-designs have been proposed...... to reduce this problem. None of these designs seems to give complete solutions. In particular, the otherwise promising depressed cladding design gives a pronounced coupling to one LP01 mode, this has been referred to as a Ghost grating. To find the modes of the fiber we have established a numerical mode......-solver based on the staircase-approximation method. The Bragg grating causes coupling between the fundamental LP01 mode and higher order LP1p modes that satisfy phase-matching. The coupling strength is determined by the overlap integral of the LP01, the LP1p mode, and the UV-induced index perturbation. For LP0...

  1. Influence of fruit drinks with or without lactobacillus Lp299v on the gastrointestinal uptake of paracetamol in man

    DEFF Research Database (Denmark)

    Akerman, Ulrika; Edvinsson, Lars

    2009-01-01

    BACKGROUND: Clinical observations have revealed that patients throw up undigested paracetamol tablets several hours following intake of rosehip drink with Lp299v (Proviva). The purpose of this study was to demonstrate if this translates into altered plasma levels of paracetamol in nineteen healthy...... subjects consuming 200 ml of water, Rose hip drink or Proviva together with 1.5 gram of paracetamol. FINDINGS: The concentration of paracetamol in plasma increased rapidly when the paracetamol-containing tablets were consumed together with water and after 30 minutes a median level of 90 mumol/l was reached...... (a 95% confidence interval of 57,161). The corresponding 30 minutes values of paracetamol levels in the presence of rosehip with or without Lp299v were 0 mumol/l (95% confidence intervals contain only zero for both rosehip treatments). There were significant differences in AUC, maximal paracetamol...

  2. Kvartsimaasälpäjauheen käyttö betonin osa-aineksena

    OpenAIRE

    Kynsilehto, Tuomas

    2017-01-01

    Opinnäytetyössä selvitettiin Keliber Oy:n toimittaman kvartsimaasälpäjauheen soveltuvuutta betonin osa-ainekseksi. Kvartsimaasälpäjauheen soveltuvuutta ei ollut aiemmin testattu. Työssä tehtiin kiviaineksen alkututkimukset ja selvitettiin, onko kvartsimaasälpäjauheen käyttö mahdollista lujuusominaisuuksiensa vuoksi, sekä mikä on kvartsimaasälpäjauheen vaikutus tuoreen betonin työstettävyysominaisuuksiin. Kvartsimaasälpäjauheen soveltuvuus testattiin luomalla yhdeksän eri normaalin, täryt...

  3. Association between cerebral cannabinoid 1 receptor availability and body mass index in patients with food intake disorders and healthy subjects: a [(18)F]MK-9470 PET study.

    Science.gov (United States)

    Ceccarini, J; Weltens, N; Ly, H G; Tack, J; Van Oudenhove, L; Van Laere, K

    2016-07-12

    Although of great public health relevance, the mechanisms underlying disordered eating behavior and body weight regulation remain insufficiently understood. Compelling preclinical evidence corroborates a critical role of the endocannabinoid system (ECS) in the central regulation of appetite and food intake. However, in vivo human evidence on ECS functioning in brain circuits involved in food intake regulation as well as its relationship with body weight is lacking, both in health and disease. Here, we measured cannabinoid 1 receptor (CB1R) availability using positron emission tomography (PET) with [(18)F]MK-9470 in 54 patients with food intake disorders (FID) covering a wide body mass index (BMI) range (anorexia nervosa, bulimia nervosa, functional dyspepsia with weight loss and obesity; BMI range=12.5-40.6 kg/m(2)) and 26 age-, gender- and average BMI-matched healthy subjects (BMI range=18.5-26.6 kg/m(2)). The association between regional CB1R availability and BMI was assessed within predefined homeostatic and reward-related regions of interest using voxel-based linear regression analyses. CB1R availability was inversely associated with BMI in homeostatic brain regions such as the hypothalamus and brainstem areas in both patients with FID and healthy subjects. However, in FID patients, CB1R availability was also negatively correlated with BMI throughout the mesolimbic reward system (midbrain, striatum, insula, amygdala and orbitofrontal cortex), which constitutes the key circuit implicated in processing appetitive motivation and hedonic value of perceived food rewards. Our results indicate that the cerebral homeostatic CB1R system is inextricably linked to BMI, with additional involvement of reward areas under conditions of disordered body weight.

  4. Dødshjælp, drabsforbud og deontologi

    DEFF Research Database (Denmark)

    Dige, Morten

    2008-01-01

    Et velkendt argument imod aktiv dødshjælp har det deontologiske forbud mod drab eller pligten til ikke at slå ihjel som en central præmis. Sådanne deontologiske argumenter spiller en fremtrædende rolle i nylige publikationer fra Det Etiske Råd. For at gælde ukvalificeret, må disse argumenter imid...

  5. LP-gas marketers nationwide reveal hardships encountered during crisis

    Energy Technology Data Exchange (ETDEWEB)

    1990-04-01

    The authors report on a survey of 150 randomly-selected LP-gas marketers nationwide. Replies were solicited from every major geographical region. The purpose of the survey was to obtain a comprehensive sampling of information on local price increases, shipping difficulties, relations with customers, and strategies for the future. This paper presents a profile that sums up the effects of the propane emergency on marketers and customers.

  6. Smell of danger: an analysis of LP-gas odorization

    Energy Technology Data Exchange (ETDEWEB)

    Cain, W.S.; Turk, A.

    1985-03-01

    LP-gas derives warning properties from the odorants ethyl mercaptan or thiophane. Laboratory tests have implied that the average person has the ability to smell the odors before leaking LP-gas reaches one-fifth its lower limit of flammability. Generally, however, laboratory tests ignore or discard persons with a poor sense of smell, especially the elderly and persons with certain types of hyposmia. Some persons who apparently can smell the warning agents when directed may otherwise fail to notice or identify them. Elderly men seem particularly vulnerable to instances of incidental anosmia and olfactory agnosia. Psychophysical testing of the warning agents has been rather unsophisticated. There exists neither a standard protocol for testing nor adequate specification of the perceptual properties that might make one warning agent better than another. Without such developments, improvement in warning agents will fail to occur. Possible improvements include increases in concentration, the use of blends to insure more uniform delivery of agent and, to decrease the perceptual vulnerability of relatively insensitive people, use of agents with favorable psychophysical (stimulus-response) functions and use of agents with favorable adaptation characteristics. Even without a change in existing products, it seems advisable to learn more about the vulnerability of LP-gas users and to employ educational means to reduce risks.

  7. Combined perianal-intrarectal (PI) lidocaine-prilocaine (LP) cream and lidocaine-ketorolac gel provide better pain relief than combined PI LP cream and periprostatic nerve block during transrectal prostate biopsy.

    Science.gov (United States)

    Cormio, Luigi; Pagliarulo, Vincenzo; Lorusso, Fabrizio; Selvaggio, Oscar; Perrone, Antonia; Sanguedolce, Francesca; Bufo, Pantaleo; Carrieri, Giuseppe

    2012-06-01

    What's known on the subject? and What does the study add? Study Type - Harm Reduction RCT Level of Evidence 1b The combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block effectively counteracts probe and sampling related pain during transrectal prostate biopsy, but not pain due to periprostatic infiltration. The novel combination of lidocaine-prilocaine cream and lidocaine-ketorolac gel, both administered perianal-intrarectally, provides the same probe and sampling-related pain relief than combined perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block and prevents the non-negligible pain due to periprostatic infiltration, thus leading to better overall patients' compliance to the procedure. • To compare the efficacy and safety of combined perianal-intrarectal (PI) lidocaine-prilocaine (LP) cream and lidocaine-ketorolac (LK) gel with combined PI LP cream and periprostatic nerve block (PPNB) in relieving pain during transrectal ultrasonography guided prostate biopsy (TPB). • In all, 200 patients were randomized to receive combined PI LP cream and LK gel (group 1) or combined PI LP cream and PPNB (group 2) before TPB. • The 0-10-point visual analogue scale (VAS) was used for assessing pain at probe insertion and movements (VAS-1), periprostatic infiltration (VAS-2) when applied, and prostate sampling (VAS-3), as well as maximal procedural pain (MPP). • Complications occurring ≤ 20 days after the TPB were recorded. • The groups were comparable for patients' age, serum PSA level, prostate volume, and cancer detection rate. • All patients tolerated the procedure well. The two anaesthetic regimens provided almost equal mean VAS-1 (0.33 vs 0.37; P= 0.701) and VAS-3 (0.52 vs 0.51; P= 0.954) scores, but patients in group 2 reported significantly greater MPP scores (0.68 vs 1.53; P PI LP cream and LK gel provided the same probe- and sampling- related pain relief as combined PI LP and PPNB; moreover

  8. Body image discrepancy and subjective norm as mediators and moderators of the relationship between body mass index and quality of life

    Directory of Open Access Journals (Sweden)

    Pétré B

    2016-11-01

    Full Text Available Benoit Pétré,1 André J Scheen,2 Olivier Ziegler,3 Anne-Françoise Donneau,1 Nadia Dardenne,1 Eddy Husson,1 Adelin Albert,1 Michèle Guillaume1 1Department of Public Health, University of Liège, Liège, Belgium; 2Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, CHU Sart Tilman, University of Liège, Liège, Belgium; 3Department of Diabetes, Metabolic Diseases and Nutrition, Nancy University Hospital, Nancy, France Background and objective: Despite the strength and consistency of the relationship between body mass index (BMI and quality of life (QoL, a reduction in BMI does not necessarily lead to an improvement in QoL. Between-subject variability indicates the presence of mediators and moderators in the BMI–QoL association. This study aimed to examine the roles of body image discrepancy (BID and subjective norm (SN as potential mediators and moderators. Subjects and methods: In 2012, 3,016 volunteers (aged ≥18 years participated in a community-based survey conducted in the French-speaking region of Belgium. Participation was enhanced using a large multimedia campaign (which was supported by a large network of recruiters that employed the nonstigmatizing slogan, “Whatever your weight, your opinion will count”. Participants were invited to complete a web-based questionnaire on their weight-related experiences. Self-reported measures were used to calculate each participant’s BMI, BID, SN, and QoL (a French obesity-specific QoL questionnaire was used to calculate the participants’ physical dimension of QoL scores [PHY-QoL], psychosocial dimension of QoL scores [PSY/SOC-QoL], and their total scores. The covariates included gender, age, subjective economic status, level of education, household size, and perceived health. The mediation/moderation tests were based on Hayes’ method. Results: Tests showed that the relationships between BMI and PHY-QoL, PSY/SOC-QoL, and TOT-QoL were partially mediated by BID

  9. Projective drawings for assessing stress among subjects with medical symptoms compatible with sick building syndrome, and validation of a modified version of the Stress Load Index from the Drawing Personality Profile: a pilot study.

    Science.gov (United States)

    Runeson, Roma; Wahlstedt, Kurt; Norbäck, Dan

    2007-02-01

    It was hypothesized that subjects with medical symptoms would show more signs of stress in projective drawings. A Stress Load Index, including five signs of stress in drawings, was evaluated. A questionnaire with an instruction to draw "a person in the rain" was sent to a cohort of 195 subjects, and the drawings were analysed blindly for eight stress items. Men had a higher index than women (p sick building syndrome symptoms (p < .05). In conclusion, a nonverbal projective drawing test detected sex differences which represent directions opposite to those with verbal methods. These need empirical assessment.

  10. [Plasma homocysteine, Lp(a), and oxidative stress markers in peripheral macroangiopathy in patients with type 2 diabetes mellitus].

    Science.gov (United States)

    Real, Jose T; Folgado, José; Molina Mendez, Mercedes; Martinez-Hervás, Sergio; Peiro, Marta; Ascaso, Juan F

    2016-01-01

    To study new risk factors for peripheral macroangiopathy (PM) in patients with diabetes, as oxidative stress (OS) and its interaction with classical risk factors: age, Lp(a), plasma homocysteine values and HbA1c. We studied 204 type2 diabetic (T2DM) patients, consecutive selected form a reference hospital and a secondary hospital form our Community (2009-2010). Design was a case (ABI1.2 and were excluded. Clinical and biological parameters were determined using standard methods. Comparing clinical and biological parameters obtained in both studied groups (T2DM+ABIdiabetes, Lp(a) and plasma homocysteine values. No differences were found in OS parameters: reduced glutathione, oxidized glutathione and maloldialdehide between studied groups. Plasma homocysteine values were an independent risk factor for the presence of PM and were related to evolution time of diabetes and reduced glutathione. We have confirmed that Lp(a) and independently plasma homocysteine values were related to PM in T2DM subjects. No association with PM and OS markers (GSH, GSSG and MDA) were found in T2DM with more than 10years of evolution time of their disease and high prevalence of chronic complications. Copyright © 2016 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. All rights reserved.

  11. No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects.

    Directory of Open Access Journals (Sweden)

    Jens Baumert

    Full Text Available Plasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI. Genome-wide association studies (GWAS have identified a variety of gene regions associated with elevated plasma fibrinogen concentrations. However, little is yet known about how associations between environmental factors and fibrinogen might be modified by genetic variation. Therefore, we conducted large-scale meta-analyses of genome-wide interaction studies to identify possible interactions of genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentration. The present study included 80,607 subjects of European ancestry from 22 studies. Genome-wide interaction analyses were performed separately in each study for about 2.6 million single nucleotide polymorphisms (SNPs across the 22 autosomal chromosomes. For each SNP and risk factor, we performed a linear regression under an additive genetic model including an interaction term between SNP and risk factor. Interaction estimates were meta-analysed using a fixed-effects model. No genome-wide significant interaction with smoking status, alcohol consumption or BMI was observed in the meta-analyses. The most suggestive interaction was found for smoking and rs10519203, located in the LOC123688 region on chromosome 15, with a p value of 6.2 × 10(-8. This large genome-wide interaction study including 80,607 participants found no strong evidence of interaction between genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentrations. Further studies are needed to yield deeper insight in the interplay between environmental factors and gene variants on the regulation of fibrinogen concentrations.

  12. Levator plate movement during voluntary pelvic floor muscle contraction in subjects with incontinence and prolapse: a cross-sectional study and review.

    Science.gov (United States)

    Thompson, Judith A; O'Sullivan, Peter B

    2003-06-01

    Transabdominal ultrasound was used to assess 104 women with incontinence and prolapse. The bladder was used as a marker of levator plate (LP) movement. The women were asked to draw in and lift the pelvic floor muscles (PFM) and a change in position of the LP in a cranial or caudal direction during contraction was documented. Three different patterns of movement of the LP were identified, with 38% of subjects elevating and 43% of subjects depressing the LP; 19% had no change in LP movement. In the stress incontinence group there was a higher than expected number that elevated the LP. In the urgency and prolapse groups there was a higher than expected number of subjects that depressed the LP ( P=0.008).The results highlight three different subgroups based on the patients' attempt to initiate elevation of the LP. Subjects who depressed the LP when instructed to elevate it appeared to adopt straining strategies via the generation of intra-abdominal pressure. Depression of the LP may have long-term negative implications for prolapse and incontinence.

  13. Cardiac output and cardiac index measured with cardiovascular magnetic resonance in healthy subjects, elite athletes and patients with congestive heart failure

    National Research Council Canada - National Science Library

    Marcus Carlsson; Ruslana Andersson; Karin Markenroth Bloch; Katarina Steding-Ehrenborg; Henrik Mosén; Freddy Stahlberg; Bjorn Ekmehag; Hakan Arheden

    2012-01-01

    ...) and thereby cardiac index (CI, CO indexed to body surface area). The aim of this study was to establish if CI decreases with age and compare the values to CI for athletes and for patients with congestive heart failure (CHF). Methods...

  14. Sparse Adaptive Channel Estimation Based on lp-Norm-Penalized Affine Projection Algorithm

    Directory of Open Access Journals (Sweden)

    Yingsong Li

    2014-01-01

    Full Text Available We propose an lp-norm-penalized affine projection algorithm (LP-APA for broadband multipath adaptive channel estimations. The proposed LP-APA is realized by incorporating an lp-norm into the cost function of the conventional affine projection algorithm (APA to exploit the sparsity property of the broadband wireless multipath channel, by which the convergence speed and steady-state performance of the APA are significantly improved. The implementation of the LP-APA is equivalent to adding a zero attractor to its iterations. The simulation results, which are obtained from a sparse channel estimation, demonstrate that the proposed LP-APA can efficiently improve channel estimation performance in terms of both the convergence speed and steady-state performance when the channel is exactly sparse.

  15. Ældre indvandrere med behov for (hjemme)hjælp

    DEFF Research Database (Denmark)

    Liversage, Anika

    2017-01-01

    utilstrækkelig kvalitet. Muligheden for at fravælge kommunal hjemmehjælp kan betinges af, af de ældre indvandrere i stedet modtager hjælp fra yngre, primært kvindelige, familiemedlemmer. Denne familiære hjælp kan dog betyde, at fx nogle svigerdøtre kommer til at varetage ganske krævende omsorgsopgaver. I nogle...

  16. Extremum of geometric functionals involving general L p $L_{p}$ -projection bodies

    Directory of Open Access Journals (Sweden)

    Weidong Wang

    2016-05-01

    Full Text Available Abstract Following the discovery of general L p $L_{p}$ -projection bodies by Ludwig, Haberl and Schuster determined the extremum of the volume of the polars of this family of L p $L_{p}$ -projection bodies. In this paper, the result of Haberl and Schuster is extended to all dual quermassintegrals, and a dual counterpart for the quermassintegrals of general L p $L_{p}$ -projection bodies is also obtained. Moreover, the extremum of the L q $L_{q}$ -dual affine surface areas of polars of general L p $L_{p}$ -projection bodies are determined.

  17. INDEX-2004

    Indian Academy of Sciences (India)

    Yogananda C S (6) 51 (GA); (7) 86 (BR). SUBJECT INDEX. A Nephew Remembers (12) 78 (PR). A Personal Memoir of Dr Beatrice Tinsley,. Astronomer (5) 84 (BR). Abelian groups (7) 70 (CR). Accelerograms (8) 79 (CR). Action potential (2) 72 (GA). Alcohol (10) 41 (GA). Algae (5) 33 (GA). Algebraic Topology (10) 86 (BR).

  18. OMPS-NPP L2 LP Aerosol Extinction Vertical Profile swath daily 3slit V1 (OMPS_NPP_LP_L2_AER675_DAILY) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — The OMPS-NPP L2 LP Aerosol Extinction Vertical Profile swath daily 3slit collection contains the retrieved aerosol extinction coefficients at 675 nm (AER675)...

  19. Infimal Convolution Regularisation Functionals of BV and Lp Spaces

    KAUST Repository

    Burger, Martin

    2016-02-03

    We study a general class of infimal convolution type regularisation functionals suitable for applications in image processing. These functionals incorporate a combination of the total variation seminorm and Lp norms. A unified well-posedness analysis is presented and a detailed study of the one-dimensional model is performed, by computing exact solutions for the corresponding denoising problem and the case p=2. Furthermore, the dependency of the regularisation properties of this infimal convolution approach to the choice of p is studied. It turns out that in the case p=2 this regulariser is equivalent to the Huber-type variant of total variation regularisation. We provide numerical examples for image decomposition as well as for image denoising. We show that our model is capable of eliminating the staircasing effect, a well-known disadvantage of total variation regularisation. Moreover as p increases we obtain almost piecewise affine reconstructions, leading also to a better preservation of hat-like structures.

  20. A fast L(p) spike alignment metric.

    Science.gov (United States)

    Dubbs, Alexander J; Seiler, Brad A; Magnasco, Marcelo O

    2010-11-01

    The metrization of the space of neural responses is an ongoing research program seeking to find natural ways to describe, in geometrical terms, the sets of possible activities in the brain. One component of this program is spike metrics-notions of distance between two spike trains recorded from a neuron. Alignment spike metrics work by identifying "equivalent" spikes in both trains. We present an alignment spike metric having L(p) underlying geometrical structure; the L(2) version is Euclidean and is suitable for further embedding in Euclidean spaces by multidimensional scaling methods or related procedures. We show how to implement a fast algorithm for the computation of this metric based on bipartite graph matching theory.

  1. 78 FR 11567 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2013-02-19

    ... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Airplanes AGENCY... Previously Held by Israel Aircraft Industries, Ltd.) Model Gulfstream G150 airplanes. This AD was prompted by...: 2013-03-23 Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd...

  2. 77 FR 44432 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2012-07-30

    ... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Airplanes AGENCY... previously held by Israel Aircraft Industries, Ltd.) Model Astra SPX, 1125 Westwind Astra, and Gulfstream 100... new AD: 2012-15-06 Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft...

  3. 78 FR 12995 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2013-02-26

    ... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Airplanes AGENCY... ] LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Model Gulfstream 100... airplane from the applicability. The Civil Aviation Authority of Israel (CAAI), which is the aviation...

  4. 77 FR 64767 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2012-10-23

    ... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Airplanes AGENCY... airworthiness directive (AD) for certain Gulfstream Aerospace LP (Type Certificate previously held by Israel... Certificate previously held by Israel Aircraft Industries, Ltd.) Model Galaxy and Gulfstream 200 airplanes...

  5. 76 FR 70040 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2011-11-10

    ... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Airplanes AGENCY... previously held by Israel Aircraft Industries, Ltd.) Model Galaxy and Gulfstream G150 airplanes; and...: 2011-23-07 Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd...

  6. 75 FR 28485 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2010-05-21

    ... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Model Gulfstream 100... Israel Aircraft Industries, Ltd.): Amendment 39-16307. Docket No. FAA-2010-0034; Directorate Identifier... Gulfstream Aerospace LP (Type Certificate previously held by Israel Aircraft Industries, Ltd.) Model...

  7. 75 FR 35017 - Brookfield Energy Marketing LP; Supplemental Notice That Initial Market-Based Rate Filing...

    Science.gov (United States)

    2010-06-21

    ... Energy Regulatory Commission Brookfield Energy Marketing LP; Supplemental Notice That Initial Market... supplemental notice in the above-referenced proceeding of Brookfield Energy Marketing LP's application for... the FERC Online links at http://www.ferc.gov . To facilitate electronic service, persons with Internet...

  8. 77 FR 28375 - Eagle Rock Desoto Pipeline, L.P.; Notice of Petition for Rate Approval

    Science.gov (United States)

    2012-05-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Eagle Rock Desoto Pipeline, L.P.; Notice of Petition for Rate Approval Take notice that on May 1, 2012, Eagle Rock Desoto Pipeline, L.P. (Desoto) filed a Rate Election pursuant to...

  9. 75 FR 27774 - Eagle Rock Desoto Pipeline, L.P.; Notice of Rate Election

    Science.gov (United States)

    2010-05-18

    ... Rock Desoto Pipeline, L.P.; Notice of Rate Election May 11, 2010. Take notice that on May 3, 2010, Eagle Rock Desoto Pipeline, L.P., (Desoto) filed a Notice of Rate Election pursuant to section 284.123(b...

  10. 77 FR 74884 - Cambria Investment Management, L.P. and Cambria ETF Trust; Notice of Application

    Science.gov (United States)

    2012-12-18

    ... COMMISSION Cambria Investment Management, L.P. and Cambria ETF Trust; Notice of Application December 12, 2012...: Cambria Investment Management, L.P. (``Cambria'') and Cambria ETF Trust (the ``Trust''). Summary of... actively-managed series, Cambria Shareholder Yield ETF (the ``Initial Fund''). The investment objective of...

  11. 76 FR 20971 - Eagle Rock Desoto Pipeline, L.P.; Notice of Filing

    Science.gov (United States)

    2011-04-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Eagle Rock Desoto Pipeline, L.P.; Notice of Filing Take notice that on April 7, 2011, Eagle Rock Desoto Pipeline, L.P. filed a revised Statement of Operating Conditions to...

  12. On the boundedness of operators in LP(ιq and Triebel-Lizorkin Spaces

    Directory of Open Access Journals (Sweden)

    João Pedro Boto

    2008-01-01

    Full Text Available Given a bounded linear operator T:LPO(ℝn→Lp1(ℝn, we state conditions under which T defines a bounded operator between corresponding pairs of Lp(ℝn;ιq spaces and Triebel-Lizorkin spaces Fp,qs(ℝn. Applications are given to linear parabolic equations and to Schrödinger semigroups.

  13. 77 FR 74280 - Proposed Information Collection (Learner's Perception (LP) Survey); Comment Request

    Science.gov (United States)

    2012-12-13

    ... AFFAIRS Proposed Information Collection (Learner's Perception (LP) Survey); Comment Request AGENCY.... Title: Learner's Perception (LP) Survey, VA Form 10-0439. OMB Control Number: 2900-0691. Type of Review... trainees perception of their clinical experience with VA versus non-VA facilities. VA will use the data to...

  14. 78 FR 11965 - Agency Information Collection (Learner's Perception (LP) Survey) Activities Under OMB Review

    Science.gov (United States)

    2013-02-20

    ... AFFAIRS Agency Information Collection (Learner's Perception (LP) Survey) Activities Under OMB Review...'s Perception (LP) Survey, VA Form 10-0439. OMB Control Number: 2900-0691. Type of Review: Extension... trainees perception of their clinical experience with VA versus non-VA facilities. VA will use the data to...

  15. Automated Test Assembly Using lp_Solve Version 5.5 in R

    Science.gov (United States)

    Diao, Qi; van der Linden, Wim J.

    2011-01-01

    This article reviews the use of the software program lp_solve version 5.5 for solving mixed-integer automated test assembly (ATA) problems. The program is freely available under Lesser General Public License 2 (LGPL2). It can be called from the statistical language R using the lpSolveAPI interface. Three empirical problems are presented to…

  16. Automated test assembly using lp_solve version 5.5 in R

    NARCIS (Netherlands)

    Diao, Qi; van der Linden, Willem J.

    2011-01-01

    This article reviews the use of the software program lp_solve version 5.5 for solving mixed-integer automated test assembly (ATA) problems. The program is freely available under Lesser General Public License 2 (LGPL2). It can be called from the statistical language R using the lpSolveAPI interface.

  17. Comparing subjective and objective indicators to describe the national entrepreneurial context: the Global Entrepreneurship Monitor and the Global Competitiveness Index contributions

    Directory of Open Access Journals (Sweden)

    Alicia Coduras

    2013-01-01

    Full Text Available Entrepreneurship research is progressing towards the construction of indexes that integrate the information of the three predominant approaches: the entrepreneurial activity output; the population’s entrepreneurial behavior, values and aspirations; and the context in which entrepreneurship takes place. In this study we compare the Global Competitiveness Index data, one of the objective sources of information selected among those recognized as descriptors of national contexts, with the national entrepreneurial context qualitative information provided by the Global Entrepreneurship Monitor. The main purpose of this research is to contribute to the knowledge of entrepreneurial context sources of information by opening a discussion around the usefulness and contribution that could make the Global Entrepreneurship Monitor source in this field, and to determine if it is recommendable to proceed to its formal validation in the short time. The obtained results evidence that the two sources do not overlap to the degree of substituting one by the other and that the Global Entrepreneurship Monitor provides relevant qualitative details about the state of entrepreneurial context that are interesting to complement the Global Competitiveness Index information. The conclusion is to recommend the formal validation of this source, being also necessary to make comparisons with other relevant sources and to clear up its role in the progress of the integrated indexes construction.

  18. Preference vs. Authority: A Comparison of Student Searching in a Subject-Specific Indexing and Abstracting Database and a Customized Discovery Layer

    Science.gov (United States)

    Dahlen, Sarah P. C.; Hanson, Kathlene

    2017-01-01

    Discovery layers provide a simplified interface for searching library resources. Libraries with limited finances make decisions about retaining indexing and abstracting databases when similar information is available in discovery layers. These decisions should be informed by student success at finding quality information as well as satisfaction…

  19. The runaway binary LP 400-22 is leaving the Galaxy

    Science.gov (United States)

    Kilic, Mukremin; Gianninas, A.; Brown, Warren R.; Harris, Hugh C.; Dahn, Conard C.; Agüeros, M. A.; Heinke, Craig O.; Kenyon, S. J.; Panei, J. A.; Camilo, Fernando

    2013-10-01

    We present optical spectroscopy, astrometry, radio and X-ray observations of the runaway binary LP 400-22. We refine the orbital parameters of the system based on our new radial velocity observations. Our parallax data indicate that LP 400-22 is significantly more distant (3σ lower limit of 840 pc) than initially predicted. LP 400-22 has a tangential velocity in excess of 830 km s-1; it is unbound to the Galaxy. Our radio and X-ray observations fail to detect a recycled millisecond pulsar companion, indicating that LP 400-22 is a double white dwarf system. This essentially rules out a supernova runaway ejection mechanism. Based on its orbit, a Galactic Centre origin is also unlikely. However, its orbit intersects the locations of several globular clusters; dynamical interactions between LP 400-22 and other binary stars or a central black hole in a dense cluster could explain the origin of this unusual binary.

  20. Low-frequency and low-intensity ultrasound irradiation to the forearm improves an index of arterial stiffness in subjects with type 2 diabetes and hypertension

    Directory of Open Access Journals (Sweden)

    Katsunori Nonogaki

    2017-09-01

    Conclusions: The low-frequency and low-intensity ultrasound irradiation to the forearm for 10 min might be useful as a preventive application for arterial stiffness in subjects with type 2 diabetes and hypertension.

  1. Mode division multiplexing coupler of four LP modes based on a five-core microstructured optical fiber

    Science.gov (United States)

    Zhang, Hongwei; Liu, Yange; Wang, Zhi; Han, Ya; Yang, Kang; Yu, Jie

    2018-03-01

    An all-fiber mode division multiplexing coupler based on a five-core microstructured optical fiber is proposed to multiplex or demultiplex LP11, LP21, LP02 and LP01 modes simultaneously. The five-core microstructured optical fiber is composed of a few mode core supporting the four LP modes propagating at 1550 nm and four single-mode cores surrounding the few-mode core. The coupling mechanism between LP01 mode in each single-mode core and the corresponding four LP modes in the few-mode core is based on avoid-crossing effect. Numerical simulation results show that coupling bandwidths of LP11, LP21, LP02 and LP01 mode are 115 nm, 56 nm, 30 nm, 46 nm respectively, with a coupling length of 2156.1 μm. The proposed mode division multiplexing coupler can multiplex or demultiplex four LP modes simultaneously with large operation bandwidth, making it a good candidate for space-division multiplexing system.

  2. 77 FR 76586 - Founders Equity SBIC I, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business...

    Science.gov (United States)

    2012-12-28

    ... Doc No: 2012-31325] SMALL BUSINESS ADMINISTRATION [License No. 02/72-0625] Founders Equity SBIC I, L.P... Notice is hereby given that Founders Equity SBIC I, L.P., 711 Fifth Avenue, 5th Floor, New York, NY 10022... (``SBA'') Rules and Regulations (13 CFR 107.730). Founders Equity SBIC I, L.P. proposes to provide debt...

  3. 78 FR 57444 - Eagle Fund III, L.P.; Notice Seeking Exemption Under the Small Business Investment Act, Conflicts...

    Science.gov (United States)

    2013-09-18

    ... ADMINISTRATION Eagle Fund III, L.P.; Notice Seeking Exemption Under the Small Business Investment Act, Conflicts of Interest Notice is hereby given that Eagle Fund III, L.P., 101 S. Hanley Road, Suite 1250, St... Business Administration (``SBA'') Rules and Regulations. Eagle Fund III, L.P., provided debt and equity...

  4. 78 FR 57444 - Eagle Fund III-A, L.P.; Notice Seeking Exemption Under the Small Business Investment Act...

    Science.gov (United States)

    2013-09-18

    ... ADMINISTRATION Eagle Fund III-A, L.P.; Notice Seeking Exemption Under the Small Business Investment Act, Conflicts of Interest Notice is hereby given that Eagle Fund III-A, L.P., 101 S. Hanley Road, Suite 1250, St... Business Administration (``SBA'') Rules and Regulations. Eagle Fund III-A, L.P., provided debt and equity...

  5. 76 FR 59767 - Plexus Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment...

    Science.gov (United States)

    2011-09-27

    ... ADMINISTRATION Plexus Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that Plexus Fund II, L.P., 200 Providence Road... Business Administration (``SBA'') Rules and Regulations (13 CFR 107.730). Plexus II, L.P., proposes to...

  6. Efficacy and safety of the probiotic Lactobacillus paracasei LP-33 in allergic rhinitis: a double-blind, randomized, placebo-controlled trial (GA2LEN Study).

    Science.gov (United States)

    Costa, D J; Marteau, P; Amouyal, M; Poulsen, L K; Hamelmann, E; Cazaubiel, M; Housez, B; Leuillet, S; Stavnsbjerg, M; Molimard, P; Courau, S; Bousquet, J

    2014-05-01

    An imbalance between Th1 and Th2 cells is involved in allergic rhinitis (AR) that may be improved by probiotics. To test the efficacy of the probiotic Lactobacillus paracasei subsp. paracasei LP-33, a double-blind, placebo-controlled, randomized trial was carried out in patients with AR to grass pollen treated with loratadine and presenting altered quality of life. Subjects with persistent AR, symptomatic during the grass pollen season, and a positive skin test or specific immunoglobulin E to grass pollens were included by general practitioners (GPs). All received loratadine for 5 weeks. The primary end point was the improvement in Rhinitis Quality of Life (RQLQ) global score at the fifth week of LP-33 consumption compared with placebo (in addition to loratadine). Secondary end points included nasal and ocular symptoms (individual and total symptom scores), visual analogue scale and time of first exacerbation of the symptoms when loratadine was stopped. A total of 425 subjects were included. Using intent-to-treat analysis, the RQLQ global score decreased significantly more in the LP-33 group than in the placebo group (P=0.0255, difference=-0.286 (95% confidence interval (CI): -0.536; -0.035)). No significant differences were noted for the change of the rhinitis total symptom score 5 global score between groups (P=0.1288, difference=-0.452 (95% CI: -1.036; 0.132)). Significant differences in ocular symptoms (RQLQ) were observed between groups (P=0.0029, difference=-0.4087 (95% CI: -0.6768; -0.1407)). This study performed by GPs shows that LP-33 improves the quality of life of subjects with persistent AR who are currently being treated with an oral H1-antihistamine. Whereas nasal symptoms had not changed, ocular symptoms had consistently improved.

  7. WOMAC Osteoarthritis Index--additional dimensions for use in subjects with post-traumatic osteoarthritis of the knee. Western Ontario and MacMaster Universities

    DEFF Research Database (Denmark)

    Roos, Ewa M.; Roos, H P; Lohmander, L S

    1999-01-01

    To compare the sensitivity of WOMAC and the two added dimensions Sport and Recreation Function and Knee Related Quality of Life in subjects with radiographic knee OA to that in controls. To study the influence of age on the reported outcomes....

  8. Measuring Subjective Quality of Life in Czech and Slovak Nurses: Validity of the Czech and Slovak Versions of Personal Wellbeing Index

    Directory of Open Access Journals (Sweden)

    ELENA GURKOVÁ

    2012-12-01

    Full Text Available The aim of this study was to investigate the psychometric properties of the Slovak and Czech versions of the Personal Well-beingIndex (PWI in population of nurses. The sample for study consisted of 1043 hospital staff nurses from 12 hospitals in the Czechand Slovak Republics. The data were collected using a set of questionnaires that included the Positive Affect Scale, the NegativeAffect Scale, and PWI. The PWI demonstrated good psychometric properties in terms of its factor structure, reliability, convergentand construct validity.

  9. INDEXING AND INDEX FUNDS

    Directory of Open Access Journals (Sweden)

    HAKAN SARITAŞ

    2013-06-01

    Full Text Available Proponents of the efficient market hypothesis believe that active portfolio management is largely wasted effort and unlikely to justify the expenses incurred. Therefore, they advocate a passive investment strategy that makes no attempt to outsmart the market. One common strategy for passive management is indexing where a fund is designed to replicate the performance of a broad-based index of stocks and bonds. Traditionally, indexing was used by institutional investors, but today, the use of index funds proliferated among individual investors. Over the years, both international and domestic index funds have disproportionately outperformed the market more than the actively managed funds have.

  10. Optical manipulation of biological particles using LP21 mode in fiber

    Science.gov (United States)

    Chen, Shijie; Huang, He; Zou, Hongmei; Li, Qing; Fu, Jian; Lin, Feng; Wu, X.

    2014-12-01

    We demonstrate the optical manipulation of biological particles using a low-order LP21 fiber mode. The focused four-lobed LP21 mode distribution was theoretically and experimentally found to be effective in optical tweezer applications, including selective cellular pick-up, pairing, grouping or separation, as well as rotation of cell dimers and clusters. Our proposed theoretical model estimates both the translational dragging force and rotational torque in good accordance with experimental data. With a simple all-fiber configuration, and low peak irradiation to target bioparticles, the proposed LP21 ‘optical chuck’ system has great application potential in biological test systems.

  11. The interleukin-1 receptor antagonist anakinra improves first-phase insulin secretion and insulinogenic index in subjects with impaired glucose tolerance

    DEFF Research Database (Denmark)

    van Poppel, P C M; van Asseldonk, E J P; Holst, Jens Juul

    2014-01-01

    Inflammation at the level of the β cell appears to be involved in progressive β-cell dysfunction in type 2 diabetes. We assessed the effect of blocking interleukin-1 (IL-1) by anakinra [recombinant human interleukin-1 receptor antagonist (IL-1Ra)] on β-cell function. Sixteen participants with imp......Inflammation at the level of the β cell appears to be involved in progressive β-cell dysfunction in type 2 diabetes. We assessed the effect of blocking interleukin-1 (IL-1) by anakinra [recombinant human interleukin-1 receptor antagonist (IL-1Ra)] on β-cell function. Sixteen participants......-phase insulin secretion improved after anakinra treatment compared with placebo, 148 ± 20 versus 123 ± 14 mU/l, respectively (p = 0.03), and the insulinogenic index was higher after anakinra treatment. These results support the concept of involvement of IL-1β in the (progressive) decrease of insulin secretion...

  12. Geometric phase due to orbit-orbit interaction: rotating LP11 modes in a two-mode fiber

    Science.gov (United States)

    Pradeep Chakravarthy, T.; Naik, Dinesh N.; Viswanathan, Nirmal K.

    2017-10-01

    Accumulation of geometric phase due to non-coplanar propagation of higher-order modes in an optical fiber is experimentally demonstrated. Vertically-polarized LP11 fiber mode, excited in a horizontally-held, torsion-free, step-index, two-mode optical fiber, rotates due to asymmetry in the propagating k-vectors, arising due to off-centered beam location at the fiber input. Perceiving the process as due to rotation of the fiber about the off-axis launch position, the orbital Berry phase accumulation upon scanning the launch position in a closed-loop around the fiber axis manifests as rotational Doppler effect, a consequence of orbit-orbit interaction. The anticipated phase accumulation as a function of the input launch position, observed through interferometry is connected to the mode rotation angle, quantified using the autocorrelation method.

  13. Pomegranate juice, but not an extract, confers a lower glycemic response on a high-glycemic index food: randomized, crossover, controlled trials in healthy subjects.

    Science.gov (United States)

    Kerimi, Asimina; Nyambe-Silavwe, Hilda; Gauer, Julia S; Tomás-Barberán, Francisco A; Williamson, Gary

    2017-10-11

    Background: Low-glycemic index diets have demonstrated health benefits associated with a reduced risk of developing type 2 diabetes.Objectives: We tested whether pomegranate polyphenols could lower the glycemic response of a high-glycemic index food when consumed together and the mechanism by which this might occur.Design: We compared the acute effect of a pomegranate juice and a polyphenol-rich extract from pomegranate (supplement) on the bread-derived postprandial blood glucose concentration in 2 randomized, crossover, controlled studies (double-blinded for the supplements), each on 16 healthy volunteers. An additional randomized, crossover, controlled study on 16 volunteers consuming constituent fruit acids in a pH-balanced solution (same pH as pomegranate) and bread was conducted to determine any contributions to postprandial responses caused by acidic beverages.Results: As primary outcome, the incremental area under the curve for bread-derived blood glucose (-33.1% ± 18.1%, P = 0.000005) and peak blood glucose (25.4% ± 19.3%, P = 0.0004) were attenuated by pomegranate juice, compared with a control solution containing the equivalent amount of sugars. In contrast, the pomegranate supplement, or a solution containing the malic and citric acid components of the juice, was ineffective. The pomegranate polyphenol punicalagin was a very effective inhibitor of human α-amylase in vitro, comparable to the drug acarbose. Neither the pomegranate extract nor the individual component polyphenols inhibited 14C-D-glucose transport across differentiated Caco-2/TC7 cell monolayers, but they inhibited uptake of 14C-glucose into Xenopus oocytes expressing the human glucose transporter type 2. Further, some of the predicted pomegranate gut microbiota metabolites modulated 14C-D-glucose and 14C-deoxy-D-glucose uptake into hepatic HepG2 cells.Conclusions: These data indicate that pomegranate polyphenols, when present in a beverage but not in a supplement, can reduce the

  14. Index and Indexing Assessment: Criteria and Standards

    Directory of Open Access Journals (Sweden)

    Hassan Ashrafi

    2007-10-01

    Full Text Available Indexing is one of the most important methods of content representation where by assigning descriptors to the documents, their subject content are made known. Since index and indexing are remarkably significant in information retrieval, its quality and evaluation and provision of criteria and standards had always been the mainstay of researchers in this field. Given the fact that Indexing is a complex process, offering definitions, principles and methods could be step towards optimal use of the information. The present study, while offering a capsule definition of index, will investigate the indexing evaluation criteria and would follow it up with a definition of indexing. Finally a number of standards in the field of indexing are presented and would make its conclusions.

  15. LP-tee pikeneb Tartust Pärnuni / Sirje Pärismaa

    Index Scriptorium Estoniae

    Pärismaa, Sirje, 1958-

    2015-01-01

    Norrast pärit tõenduspõhist koostöökultuuri arendava LP-mudeliga (learning environment and pedagogical analysis) on liitumas seitse kooli Pärnust, Viljandist, Puhjast, Tartust ning kolm lasteaeda

  16. LibraryH3lp: A New Flexible Chat Reference System

    Directory of Open Access Journals (Sweden)

    Pam Sessoms

    2008-09-01

    Full Text Available LibraryH3lp is an integrated IM and web chat system designed specifically for Virtual Reference services in libraries. The software was designed for, and is currently used by, a night-time chat reference collaboraton between several large academic libraries. LibraryH3lp is designed for the workflow of chat reference, supporting multiple simultaneous operators and routing to queues of operators in a particular service area. It also supports web page embeddable chat 'widgets', as well as simultaneous gateways to multiple IM protocols. This article discusses the motivation for the development of the software, and provides an overview of LibraryH3lp's features and technical architecture. Parts of LibraryH3lp are available as open source. The complete application is available as a low-cost hosted service, and will eventually be available to be licensed for local hosting.

  17. Characterization of LpGPAT Gene in Lilium pensylvanicum and Response to Cold Stress

    Directory of Open Access Journals (Sweden)

    Shao-kun Sun

    2015-01-01

    Full Text Available LpGPAT was obtained from L. pensylvanicum using RT-PCR and rapid amplification of cDNA ends. The cloned full-length cDNA was 1544 bp; it encoded 410 amino acids and had a molecular size of 46 KDa. The nucleic acid sequence analysis showed that it shared high homology with other known GPATs. SMAT result suggests that there is a PlsC that exists in 176-322 amino acid sequence of LpGAPT; it means LpGPAT protein is a member of the family of acyltransferase and has acyltransferase enzymatic activity. Result of real-time quantitative PCR and semiquantitative PCR support LpGPAT gene is definitely induced by low temperature stress.

  18. LP MOON GAMMA RAY SPECTROMETER 3 RDR V1.0

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set contains processed LP-GRS time-series data that are used as the fundamental data for deriving composition measurements of the lunar surface using...

  19. Mapping breast cancer blood flow index, composition, and metabolism in a human subject using combined diffuse optical spectroscopic imaging and diffuse correlation spectroscopy

    Science.gov (United States)

    Yazdi, Hossein S.; O'Sullivan, Thomas D.; Leproux, Anais; Hill, Brian; Durkin, Amanda; Telep, Seraphim; Lam, Jesse; Yazdi, Siavash S.; Police, Alice M.; Carroll, Robert M.; Combs, Freddie J.; Strömberg, Tomas; Yodh, Arjun G.; Tromberg, Bruce J.

    2017-04-01

    Diffuse optical spectroscopic imaging (DOSI) and diffuse correlation spectroscopy (DCS) are model-based near-infrared (NIR) methods that measure tissue optical properties (broadband absorption, μa, and reduced scattering, μs‧) and blood flow (blood flow index, BFI), respectively. DOSI-derived μa values are used to determine composition by calculating the tissue concentration of oxy- and deoxyhemoglobin (HbO2, HbR), water, and lipid. We developed and evaluated a combined, coregistered DOSI/DCS handheld probe for mapping and imaging these parameters. We show that uncertainties of 0.3 mm-1 (37%) in μs‧ and 0.003 mm-1 (33%) in μa lead to ˜53% and 9% errors in BFI, respectively. DOSI/DCS imaging of a solid tissue-simulating flow phantom and a breast cancer patient reveals well-defined spatial distributions of BFI and composition that clearly delineates both the flow channel and the tumor. BFI reconstructed with DOSI-corrected μa and μs‧ values had a tumor/normal contrast of 2.7, 50% higher than the contrast using commonly assumed fixed optical properties. In conclusion, spatially coregistered imaging of DOSI and DCS enhances intrinsic tumor contrast and information content. This is particularly important for imaging diseased tissues where there are significant spatial variations in μa and μs‧ as well as potential uncoupling between flow and metabolism.

  20. The relationship among body mass index, subjective reporting of chronic disease, and the use of health care services in Newfoundland and Labrador, Canada.

    Science.gov (United States)

    Twells, Laurie K; Knight, John; Alaghehbandan, Reza

    2010-02-01

    The purpose of the study was to examine the association of body mass index (BMI) with the prevalence of chronic disease and health services use in adults living in Newfoundland and Labrador (NL). A cross-sectional analysis of 2345 adult respondents to the 2001 Canadian Community Health Survey was performed. Outcome measures included the prevalence of chronic disease and health services use. The sample comprised normal (37%), overweight (39%), obese (17%), and morbidly obese (6%) individuals. Obese and morbidly obese individuals were more likely to report the presence of a chronic disease. Adjusting for age and sex, increasing BMI category was significantly associated with a greater likelihood of cardiovascular, endocrine, and pulmonary diseases (excluding asthma). The majority of survey respondents in each category reported having a regular doctor (>75%), and there were no significant differences across categories. Compared to those with a normal BMI, obese and morbidly obese individuals reported a significantly higher number of visits to a family physician. There were no differences across BMI categories and the use of specialist or hospital services. Almost a quarter of the study sample in NL was classified as morbidly obese or obese. These individuals reported more chronic conditions and more visits to a family physician than the normal-weight group. The greater morbidity and the increased frequency of visits to family physicians suggests greater consideration should be given to channeling financial and human resources to the primary health care of this high-risk population.

  1. The E-wave propagation index (EPI): A novel echocardiographic parameter for prediction of left ventricular thrombus. Derivation from computational fluid dynamic modeling and validation on human subjects.

    Science.gov (United States)

    Harfi, Thura T; Seo, Jung-Hee; Yasir, Hayder S; Welsh, Nathaniel; Mayer, Susan A; Abraham, Theodore P; George, Richard T; Mittal, Rajat

    2017-01-15

    To describe the derivation and validation of a novel echocardiographic metric for prediction of left ventricle thrombus (LVT). Computational fluid dynamic modeling using cardiac CT images was used to derive a novel echocardiography-based metric to predict the presence of LVT. We retrospectively reviewed 25 transthoracic echocardiograms showing definite LVT (LVT group). We then randomly selected 25 patients with LVEF ≥55% (Normal EF group) and 25 patients with severe cardiomyopathy (CMP) with LVEF ≤40% without evidence of LVT (CMP group). The E-wave Propagation Index (EPI) was measured as the E-wave velocity time-integral divided by the LV length. An EPI>1 indicates penetration of the mitral jet into the apex whereas an EPIEPI was compared between the three groups. Crude and adjusted odd ratios of EPI and LVT association were also measured. Mean EPI was highest for the normal EF group and lowest in the LVT group (1.7 vs. 0.8; pEPI also differed significantly between LVT and CMP groups (0.8 vs. 1.2; pEPI EPI EPI of less than 1 is an independent predictor of LVT formation. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  2. HT-LP thermometamorphism modelling : Agly massif, French Pyrenees.

    Science.gov (United States)

    Tournaire Guille, Baptiste; Pascal, Marie-Lola; Lejeune, Anne-Marie; Annen, Catherine

    2017-04-01

    Owing to the strongly anomalous thermal gradients implied, HT-LP metamorphism is a worldwide type of processes in which magma emplacement and solidification at relatively high levels in the crust must be considered as a potentially major heat source. Thermal modelling (e.g. Annen et al. 2005) is an appropriate tool for constraining the part played by such processes in practical cases of thermometamorphism. We study the Agly massif, an exhumed part of middle crust from the Variscan belt in the French Pyrenees. This massif is a classical example of HT-LP metamorphism (Vielzeuf 1996), composed of a metasedimentary cover, mainly micaschists aged from upper Cambrian to Devonian, unconformably overlying an older basement of para- and orthogneisses. The Variscan metamorphic facies extend from greenschists, in the upper part of the cover, to granulites in the basement (Fonteilles 1976). The apparent geotherm of about 110°/km in the metasedimentary cover (amphibolite and greenschist facies) has given way to contrasting interpretations. Magmatic activity partly synchronous with and probably related to the Variscan thermometamorphism is observed at the outcropping level as at least 4 magmatic bodies of mantle origin (Touil 1994), of Stephanian age, including granodiorites and subordinate diorites and gabbros. Recent U/Pb datations on zircons (Tournaire-Guille et al., in prep) also reveal the presence of lower Cambrian magmatism in the gneisses, therefore confirming their interpretation as a pre-Variscan basement. The location (depth), volume (thickness), temperature (composition) and timing of magma emplacement are the parameters controlling the thermal effect to be modelled with a Matlab® code (Annen et al. 2005). In order to constrain these parameters, we have updated the lithostratigraphy and the PT conditions of the Variscan metamorphism in the Agly area. Mineralogic and petrologic data exploited in thermobarometric analyses compared with thermodynamic PerpleX modelling

  3. A study on the physical fitness index, heart rate and blood pressure in different phases of lunar month on male human subjects

    Science.gov (United States)

    Chakraborty, Ujjwal; Ghosh, Tusharkanti

    2013-09-01

    The gravitational pull of the moon on the earth is not the same in all phases of the lunar month, i.e. new moon (NM), first quarter (FQ), full moon (FM) and third quarter (TQ), and as a result the amplitude of tide differs in different phases. The gravitational pull of the moon may have effects on the fluid compartments of the human body and hence the cardiovascular system may be affected differentially in the different phases of the lunar month. In the present study resting heart rate (HR) and blood pressure (BP), physical fitness index (PFI), peak HR and BP immediately after step test, and recovery HR and BP after step test were measured during different phases of the lunar month in 76 male university students (age 23.7 ± 1.7 years). At rest, both systolic and mean arterial BP were ˜5 mmHg lower in NM and FM compared to FQ and TQ, but resting HR was not significantly different between phases. Further, peak HR and peak systolic BP after step test were lower (˜4 beat/min and ˜5 mmHg, respectively) in NM and FM compared to FQ and TQ. PFI was also higher (˜5) in NM and FM compared to FQ and TQ. Recovery of HR after step test was quicker in NM and FM compared to that of FQ and TQ. It appears from this study that gravitational pull of the moon may affect the cardiovascular functions of the human body. Moreover, the physical efficiency of humans is increased in NM and FM due to these altered cardiovascular regulations.

  4. Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice

    Science.gov (United States)

    DEMİRKAYA, Kadriye; AKGÜN, Özlem Martı; ŞENEL, Buğra; ÖNCEL TORUN, Zeynep; SEYREK, Melik; LACİVİTA, Enza; LEOPOLDO, Marcello; DOĞRUL, Ahmet

    2016-01-01

    ABSTRACT The most recently identified serotonin (5-HT) receptor is the 5-HT7 receptor. The antinociceptive effects of a 5-HT7 receptor agonist have been shown in neuropathic and inflammatory animal models of pain. A recent study demonstrated the functional expression of 5-HT7 receptors in the substantia gelatinosa (SG) of the trigeminal subnucleus caudalis, which receives and processes orofacial nociceptive inputs. Objective To investigate the antinociceptive effects of pharmacological activation of 5-HT7 receptors on orofacial pain in mice. Material and Methods Nociception was evaluated by using an orofacial formalin test in male Balb-C mice. Selective 5-HT7 receptor agonists, LP 44 and LP 211 (1, 5, and 10 mg/kg), were given intraperitoneally 30 min prior to a formalin injection. A bolus of 10 µl of 4% subcutaneous formalin was injected into the upper lip of mice and facial grooming behaviors were monitored. The behavioral responses consisted of two distinct periods, the early phase corresponding to acute pain (Phase I: 0–12 min) and the late phase (Phase II: 12–30 min). Results LP 44 and LP 211 (1, 5, and 10 mg/kg) produced an analgesic effect with reductions in face rubbing time in both Phase I and Phase II of the formalin test. Conclusion Our results suggest that 5-HT7 receptor agonists may be promising analgesic drugs in the treatment of orofacial pain. PMID:27383702

  5. Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice.

    Science.gov (United States)

    Demirkaya, Kadriye; Akgün, Özlem Martı; Şenel, Buğra; Öncel Torun, Zeynep; Seyrek, Melik; Lacivita, Enza; Leopoldo, Marcello; Doğrul, Ahmet

    2016-01-01

    To investigate the antinociceptive effects of pharmacological activation of 5-HT7 receptors on orofacial pain in mice. Nociception was evaluated by using an orofacial formalin test in male Balb-C mice. Selective 5-HT7 receptor agonists, LP 44 and LP 211 (1, 5, and 10 mg/kg), were given intraperitoneally 30 min prior to a formalin injection. A bolus of 10 µl of 4% subcutaneous formalin was injected into the upper lip of mice and facial grooming behaviors were monitored. The behavioral responses consisted of two distinct periods, the early phase corresponding to acute pain (Phase I: 0-12 min) and the late phase (Phase II: 12-30 min). LP 44 and LP 211 (1, 5, and 10 mg/kg) produced an analgesic effect with reductions in face rubbing time in both Phase I and Phase II of the formalin test. Our results suggest that 5-HT7 receptor agonists may be promising analgesic drugs in the treatment of orofacial pain.

  6. Characterization of Lactobacillus plantarum Lp27 isolated from Tibetan kefir grains: a potential probiotic bacterium with cholesterol-lowering effects.

    Science.gov (United States)

    Huang, Ying; Wu, Fei; Wang, Xiaojun; Sui, Yujie; Yang, Longfei; Wang, Jinfeng

    2013-05-01

    Lactobacillus plantarum Lp27 was isolated from Tibetan kefir grains. The Lp27 isolate survived a 3-h incubation at pH 2.0 and grew normally in 0.3% oxgall. In addition, the Lp27 isolate exhibited an adhesion ratio of 9.5 ± 2.5% with Caco-2 cells. Antibiotic susceptibility tests indicated that the Lp27 isolate was sensitive to gentamicin, tetracycline, erythromycin, and chloramphenicol, and was resistant to vancomycin with a minimum inhibitory value of 23µg/mL. The Lp27 isolate inhibited cholesterol absorption through downregulation of Niemann-Pick C1-like 1 (NPC1L1) expression in Caco-2 cells. The Lp27 isolate was fed to hypercholesterolemic rats at a dose of 10(9) cfu/d for 4wk. The Lp27 feeding significantly lowered serum total cholesterol, low-density lipoprotein cholesterol, and triglycerides concentrations, but no change was observed in the serum high-density lipoprotein cholesterol concentrations. In addition, liver total cholesterol and triglycerides were decreased in the Lp27-fed group. The expression of NPC1L1 in the duodenum and jejunum was significantly decreased following Lp27 feeding. These results indicate that Lp27 might be an effective cholesterol-lowering probiotic and a possible mechanism for the cholesterol-reducing effects of probiotics. Copyright © 2013 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  7. HeLP-Diabetes: randomised controlled trial protocol.

    Science.gov (United States)

    Murray, Elizabeth; Dack, Charlotte; Barnard, Maria; Farmer, Andrew; Li, Jinshuo; Michie, Susan; Pal, Kingshuk; Parrott, Steve; Ross, Jamie; Sweeting, Michael; Wood, Bindie; Yardley, Lucy

    2015-12-29

    Type 2 Diabetes Mellitus (T2DM) is common, affecting nearly 400 million people worldwide. Achieving good health for people with T2DM requires active self-management; however, uptake of self-management education is poor, and there is an urgent need to find better, more acceptable, cost-effective methods of providing self-management support. Web-based self-management support has many potential benefits for patients and health services. The aim of this trial is to determine the effectiveness and cost-effectiveness of a web-based self-management support programme for people with T2DM. This will be a multi-centre individually randomised controlled trial in primary care, recruiting adults with T2DM who are registered with participating general practices in England. Participants will be randomised to receive either an evidence-based, theoretically informed, web-based self-management programme for people with T2DM which addresses medical, emotional, and role management, called Healthy Living for People with type 2 Diabetes (HeLP-Diabetes) or a simple information website. The joint primary outcomes are glycated haemoglobin (HbA1c) and diabetes-related distress, measured by the Problem Areas In Diabetes (PAID) questionnaire. Secondary outcomes include cardiovascular risk factors, depression and anxiety, and self-efficacy for self-management of diabetes. Health economic data include health service use, costs due to the intervention, and EQ-5D for calculation of Quality Adjusted Life Years (QALYS). Data will be collected at baseline, 3 months and 12 months, with the primary endpoint at 12 months. Practice nurses, blinded to patient allocation, collect clinical data; patients complete online questionnaires for patient reported measures. A sample size of 350 recruited participants allows for attrition of up to 15 % and will provide 90 % power of detecting at a 5 % significance level a true average difference in the PAID score of 4.0 and 0.25 % change in HbA1c (both small effect

  8. Lipoprotein-Associated Phospholipase A2 Mass Level Is Increased in Elderly Subjects with Type 2 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    J. Fortunato

    2014-01-01

    Full Text Available Objective. Lipoprotein-associated phospholipase A2 (Lp-PLA2 is extensively expressed by advanced atherosclerotic lesions and may play a role in plaque instability. We selected a group of elderly subjects that underwent transcatheter aortic valve implantation (TAVI or balloon angioplasty (BA and separated them into two groups, diabetic and nondiabetic, to compare the level of Lp-PLA2 mass between them. Methods. 44 patients aged 79.6±5.6 years with symptomatic severe aortic valve stenosis underwent TAVI (n=35 or BA (n=9. 21 subjects had confirmed type 2 diabetes mellitus. Lp-PLA2 mass was measured using an enzyme-linked immunosorbent assay kit (USCN Life Science, China before and 3 days after the procedure. Results. Lp-PLA2 mass was significantly elevated in this population (1296±358 ng/mL before TAVI; 1413±268 ng/mL before BA and further increased after TAVI (1604±437 ng/mL, P<0.01 or BA (1808±303 ng/mL, P<0.01. Lp-PLA2 mass was significantly increased on the diabetic group before these interventions. Conclusion. Lp-PLA2 may be a novel biomarker for the presence of rupture-prone atherosclerotic lesions in elderly patients. Levels of Lp-PLA2 in diabetic patients may accompany the higher amount of small dense LDL particles seen in these subjects.

  9. HUBUNGAN PENGGUNAAN LP-LPO DENGAN KECUKUPAN DAN KERASIONALAN PENGGUNAAN OBAT DI PUSKESMAS

    Directory of Open Access Journals (Sweden)

    Max Joseph Herman

    2012-09-01

    Full Text Available A study to determine the impact of the implementation of LP-LPO (Drug-use Report and Drug-request Form upon the availability and the rational use of drugs at Puskesmas (Health Centre had been carried out during 1998. The study location were four districts, i.e. Pasaman and Agam in West Sumatera and Pasuruan and Malang in East Java. The survey was conducted retrospectively by visiting 40 PHCs selected purposively to interview, observe and tranfer data from 1997/1998 LP-LPO. Data concerning the implementation of LP-LPO through some variables, the availability of drugs and an evaluation of rational prescription based on the standard treatment guidelines in the year of 1997/1998 were collected. Multiple regression was used to analyze the correlation among variables of the implementation of LP-LPO and the availability as well as the rational use of drugs, following a general description of each variable involved at selected HCs. The study revealed good results in the implementation of LP-LPO to manage the availability of indicator drugs at HCs. However, at most HCs the drug supply did not fit the request. The percentages of HCs in implementing LP-LPO in terms of variables of planning, scheduling, record keeping, timing of reporting, methods and data resources ranged from 50 to 80%. Statistically there was a significant correlation between the implementation of LP-LPO in terms of the above variables and the availability of drugs. On the contrary, there was no statistically significant correlation between drug availability and rational prescription, which was found only at 5% of HCs.

  10. The Healthy Lifestyles Programme (HeLP), a novel school-based intervention to prevent obesity in school children: study protocol for a randomised controlled trial

    Science.gov (United States)

    2013-01-01

    Background Over the last three decades there has been a substantial increase in the proportion of children who are overweight or obese. The Healthy Lifestyles Programme (HeLP) is a novel school-based intervention, using highly interactive and creative delivery methods to prevent obesity in children. Methods/Design We describe a cluster randomised controlled trial to evaluate the effectiveness and cost effectiveness of HeLP. The intervention has been developed using intervention mapping (involving extensive stakeholder involvement) and has been guided by the Information, Motivation, Behavioural Skills model. HeLP includes creating a receptive environment, drama activities, goal setting and reinforcement activities and runs over three school terms. Piloting showed that 9 to 10 year olds were the most receptive and participative. This study aims to recruit 1,300 children from 32 schools (over half of which will have ≥19% of pupils eligible for free school meals) from the southwest of England. Participating schools will be randomised to intervention or control groups with baseline measures taken prior to randomisation. The primary outcome is change in body mass index standard deviation score (BMI SDS) at 24 months post baseline. Secondary outcomes include, waist circumference and percent body fat SDS and proportion of children classified as overweight or obese at 18 and 24 months and objectively measured physical activity and food intake at 18 months. Between-group comparisons will be made using random effects regression analysis taking into account the hierarchical nature of the study design. An economic evaluation will estimate the incremental cost-effectiveness of HeLP, compared to control, from the perspective of the National Health Service (NHS)/third party payer. An in-depth process evaluation will provide insight into how HeLP works, and whether there is any differential uptake or engagement with the programme. Discussion The results of the trial will provide

  11. Analysis of error floor of LDPC codes under LP decoding over the BSC

    Energy Technology Data Exchange (ETDEWEB)

    Chertkov, Michael [Los Alamos National Laboratory; Chilappagari, Shashi [UNIV OF AZ; Vasic, Bane [UNIV OF AZ; Stepanov, Mikhail [UNIV OF AZ

    2009-01-01

    We consider linear programming (LP) decoding of a fixed low-density parity-check (LDPC) code over the binary symmetric channel (BSC). The LP decoder fails when it outputs a pseudo-codeword which is not a codeword. We propose an efficient algorithm termed the instanton search algorithm (ISA) which, given a random input, generates a set of flips called the BSC-instanton and prove that: (a) the LP decoder fails for any set of flips with support vector including an instanton; (b) for any input, the algorithm outputs an instanton in the number of steps upper-bounded by twice the number of flips in the input. We obtain the number of unique instantons of different sizes by running the ISA sufficient number of times. We then use the instanton statistics to predict the performance of the LP decoding over the BSC in the error floor region. We also propose an efficient semi-analytical method to predict the performance of LP decoding over a large range of transition probabilities of the BSC.

  12. Immunomodulatory Effects of Lactobacillus plantarum Lp62 on Intestinal Epithelial and Mononuclear Cells

    Directory of Open Access Journals (Sweden)

    Thalis Ferreira dos Santos

    2016-01-01

    Full Text Available Probiotic lactic acid bacteria are known for their ability to modulate the immune system. They have been shown to inhibit inflammation in experiments with animal models, cell culture, and clinical trials. The objective of this study was to elucidate the anti-inflammatory potential of Lactobacillus plantarum Lp62, isolated from cocoa fermentation, in a cell culture model. Lp62 inhibited IL-8 production by Salmonella Typhi-stimulated HT-29 cells and prevented the adhesion of pathogens to these epithelial cells. The probiotic strain was able to modulate TNF-α, IL1-β, and IL-17 secretion by J774 macrophages. J774 activation was reduced by coincubation with Lp62. PBMC culture showed significantly higher levels of CD4+CD25+ T lymphocytes following treatment with Lp62. Probiotics also induced increased IL-10 secretion by mononuclear cells. L. plantarum Lp62 was able to inhibit inflammatory stimulation in epithelial cells and macrophages and activated a tolerogenic profile in mononuclear cells of healthy donors. These results indicate this strain for a possible application in the treatment or prevention of inflammatory diseases.

  13. Genetic invalidation of Lp-PLA2 as a therapeutic target

    DEFF Research Database (Denmark)

    Gregson, John M; Freitag, Daniel F; Surendran, Praveen

    2017-01-01

    AIMS: Darapladib, a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), has not reduced risk of cardiovascular disease outcomes in recent randomized trials. We aimed to test whether Lp-PLA2 enzyme activity is causally relevant to coronary heart disease. METHODS: In 72......,657 patients with coronary heart disease and 110,218 controls in 23 epidemiological studies, we genotyped five functional variants: four rare loss-of-function mutations (c.109+2T > C (rs142974898), Arg82His (rs144983904), Val279Phe (rs76863441), Gln287Ter (rs140020965)) and one common modest-impact variant...... to compare effects of darapladib treatment on soluble Lp-PLA2 activity, conventional cardiovascular risk factors, and coronary heart disease risk with corresponding effects of Lp-PLA2-lowering alleles. RESULTS: Lp-PLA2 activity was decreased by 64% (p = 2.4 × 10(-25)) with carriage of any of the four loss...

  14. [Changes in lipoprotein (a) [Lp(a)] level after an ischemic stroke].

    Science.gov (United States)

    Wehr, Hanna; Rado, Maria; Mendel, Tadeusz; Swiderska, Małgorzata; Bednarska-Makaruk, Małgorzata; Szirkowiec, Walentyna

    2004-01-01

    The aim of the work was to recognize whether often observed high levels of apolipoprotein (a) [Lp(a)] in patients shortly after an ischemic stroke are a result of the acute phase reaction. In 13 patients Lp(a) was determined within the first 24 hours after the stroke onset, after the next 7 days and after three months i.e. when it could be considered that Lp(a) level was the same as before onset of the disease. In 17 patients only two determinations were performed. Another acute phase indicator: C-reactive protein (CRP), as well as serum lipids were also determined. CRP level was increased in the first determination and increased further after 7 days. After three months it returned to low values. High density lipoprotein (HDL) cholesterol which demonstrates a negative acute phase response changed in the opposite way. No similar fluctuations of Lp(a) level were observed. It can be concluded that during the investigated period Lp(a) had no properties of the acute phase reactant.

  15. The lysine-peptoid hybrid LP5 maintain activity under physiological conditions and affects virulence gene expression in Staphylococcus aureus

    DEFF Research Database (Denmark)

    Gottschalk, Sanne; Ingmer, Hanne; Thomsen, Line E.

    2016-01-01

    The antimicrobial peptide, LP5, is a lysine-peptoid hybrid, with antimicrobial activity against clinically relevant bacteria. Here, we investigated how various environmental conditions affect the antimicrobial activity of LP5 against Staphylococcus aureus (S. aureus). We found that LP5 maintained...... to sub-inhibitory concentrations of LP5 affected the expression of the major virulence factors of S. aureus, revealing a potential as anti virulence compound. Thus, these results show how environmental factors affect the peptide efficiency and further add to the knowledge on how the peptide affects S...

  16. Circulating and PBMC Lp-PLA2 associate differently with oxidative stress and subclinical inflammation in nonobese women (menopausal status.

    Directory of Open Access Journals (Sweden)

    Jean Kyung Paik

    Full Text Available BACKGROUND: This study aimed to determine the association of lipoprotein-associated phospholipase A(2 (Lp-PLA(2 activity in circulation and peripheral blood mononuclear cells (PBMCs with inflammatory and oxidative stress markers in nonobese women and according to menopausal status. Lp-PLA(2 activity, a marker for cardiovascular risk is associated with inflammation and oxidative stress. METHODOLOGY/PRINCIPAL FINDINGS: Eighty postmenopausal women (53.0±4.05 yr and 96 premenopausal women (39.7±9.25 yr participated in this study. Lp-PLA(2 activities, interleukin (IL-6, tumor necrosis factor (TNF-α, and IL-1β in plasma as well as in PBMCs were measured. Plasma ox-LDL was also measured. Postmenopausal women demonstrated higher circulating levels of ox-LDL and IL-6, as well as IL-6, TNF-α, and IL-1β in PBMCs, than premenopausal women. In both groups, plasma Lp-PLA(2 activity positively correlated with Lp-PLA(2 activity in PBMCs and plasma ox-LDL. In premenopausal women, Lp-PLA(2 activities in plasma and PBMCs positively correlated with IL-6, TNF-α, and IL-1β in PBMCs. In postmenopausal women, plasma ox-LDL positively correlated with PBMC cytokine production. In subgroup analysis of postmenopausal women according to plasma ox-LDL level (median level: 48.715 U/L, a significant increase in Lp-PLA(2 activity in the plasma but not the PBMCs was found in the high ox-LDL subgroup. Plasma Lp-PLA(2 activity positively correlated with unstimulated PBMC Lp-PLA(2 activity in the low ox-LDL subgroup (r = 0.627, P<0.001, whereas in the high ox-LDL circulating Lp-PLA(2 activity positively correlated with plasma ox-LDL (r = 0.390, P = 0.014 but not with Lp-PLA(2 activity in PBMCs. CONCLUSIONS/SIGNIFICANCE: The lack of relation between circulating Lp-PLA(2 activity and Lp-PLA(2 activity in PBMCs was found in postmenopausal women with high ox-LDL. This may indicate other sources of circulating Lp-PLA(2 activity except PBMC in postmenopausal women

  17. The antimicrobial lysine-peptoid hybrid LP5 inhibits DNA replication and induces the SOS response in Staphylococcus aureus

    DEFF Research Database (Denmark)

    Gottschalk, Sanne; Ifrah, Dan; Lerche, Sandra

    2013-01-01

    the growth of S. aureus without ATP leakage. Instead, LP5 bound DNA and inhibited macromolecular synthesis. The binding to DNA also led to inhibition of DNA gyrase and topoisomerase IV and caused induction of the SOS response. CONCLUSIONS: Our data demonstrate that LP5 may have a dual mode of action against...... S. aureus. At MIC concentrations, LP5 binds DNA and inhibits macromolecular synthesis and growth, whereas at concentrations above the MIC, LP5 targets the bacterial membrane leading to disruption of the membrane. These results add new information about the MOA of a new synthetic AMP and aid...... in the future design of synthetic peptides with increased therapeutic potential....

  18. Subject-Author Index 989..1009

    Indian Academy of Sciences (India)

    White Spot Syndrome Virus infection in Penaeus monodon is facilitated by housekeeping molecules. 917. Auditory pathway. Role of sound stimulation in reprogramming brain connectivity. 605. Autism Spectrum Disorder. Maternal hormonal interventions as a risk factor for Autism Spectrum Disorder: An epidemiological.

  19. subject index - Indian Academy of Sciences

    Indian Academy of Sciences (India)

    -geological potential of Varanasi area, U.P.,. India. 489. Characteristic period. Considerations on seismic microzonation in areas with two-dimensional hills. 783. Characteristic site period. Seismic hazard assessment of Chennai city consider-.

  20. Subject Index S¯adhan¯a

    Indian Academy of Sciences (India)

    processed images. 37. High speed preprocessing system. 511. Incompressibility constraint. Behaviour of Lagrangian triangular mixed fluid finite elements. 21. Inductively coupled plasma. Design, fabrication and performance evaluation of a 22-channel direct reading atomic emission spectrometer using inductively coupled ...

  1. subject index - Indian Academy of Sciences

    Indian Academy of Sciences (India)

    25 E) India. 229. Atmospheric composition, physics and chemistry. An experimental set-up for carbon isotopic analysis of atmospheric CO2 and an example of ecosystem response during solar eclipse 2010. 623. Diurnal and semi-diurnal tidal structures due to O2, O3 and H2O heating. 1207. Atmospheric Sciences. A simple ...

  2. Inhibitors for the bacterial ectonucleotidase Lp1NTPDase from Legionella pneumophila.

    Science.gov (United States)

    Fiene, Amelie; Baqi, Younis; Malik, Enas M; Newton, Patrice; Li, Wenjin; Lee, Sang-Yong; Hartland, Elizabeth L; Müller, Christa E

    2016-09-15

    Legionella pneumophila is an aerobic, Gram-negative bacterium of the genus Legionella, which constitutes the major causative agent of Legionnaires' disease. Recently a nucleoside triphosphate diphosphohydrolase (NTPDase) from L. pneumophila was identified and termed Lp1NTPDase; it was found to be a structural and functional homolog of mammalian NTPDases catalyzing the hydrolysis of ATP to ADP and ADP to AMP. Its activity is believed to contribute to the virulence of Legionella pneumophila. Therefore Lp1NTPDase inhibitors are considered as novel antibacterial drugs. However, only weakly potent compounds are available so far. In the present study, a capillary electrophoresis (CE)-based enzyme assay for monitoring the Lp1NTPDase activity was established. The enzymatic reaction was performed in a test tube followed by separation of substrate and products by CE and subsequent quantification by UV analysis. After kinetic characterization of the enzyme, a series of 1-amino-4-ar(alk)ylamino-2-sulfoanthraquinone derivatives structurally related to the anthraquinone dye Reactive Blue 2, a non-selective ecto-NTPDase inhibitor, was investigated for inhibitory activity on Lp1NTPDase using the CE-based enzyme assay. Derivatives bearing a large lipophilic substituent (e.g., fused aromatic rings) in the 4-position of the 1-amino-2-sulfoanthraquinone showed the highest inhibitory activity. Compounds with IC50 values in the low micromolar range were identified. The most potent inhibitor was 1-amino-4-[phenanthrene-9-yl-amino]-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate (28, PSB-16131), with an IC50-value of 4.24μM. It represents the most potent Lp1NTPDase inhibitor described to date. These findings may serve as a starting point for further optimization. Lp1NTPDase inhibition provides a novel approach for the (immuno)therapy of Legionella infections. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Capillary tone: cyclooxygenase, shear stress, luminal glycocalyx, and hydraulic conductivity (Lp).

    Science.gov (United States)

    Williams, Donna A; Flood, Mary H

    2015-04-01

    Control of capillary hydraulic conductivity (Lp) is the physiological mechanism that underpins systemic hydration. Capillaries form the largest surface of endothelial cells in any species with a cardiovascular system and all capillaries are exposed to the flow-induced force, shear stress (τ). Vasoactive molecules such as prostacyclin (cyclooxygenase product, COX) are released from endothelial cells in response to τ. Little is known about how COX activity impacts capillary Lp. The purpose here was to assess Lp in situ following an acute Δτ stimulus and during COX1/COX2 inhibition. Mesenteric true capillaries (TC) of Rana pipiens (pithed) were cannulated for Lp assessment using the modified Landis technique. Rana were randomized into Control and Test groups. Two capillaries per animal were used (perfusate, 10 mg·mL(-1) BSA/frog Ringer's; superfusate, frog Ringer's or indomethacin (10(-5) mol·L(-1)) mixed in frog Ringer's solution). Three distinct responses of Lp to indomethacin (TC2) were demonstrated (TC1 and TC2 medians: Test Subgroup 1, 3.0 vs. 1.8; Test Subgroup 2, 18.2 vs. 2.2; Test Subgroup 3, 4.2 vs. 10.2 × 10(-7) cm·sec(-1)·cm H2O(-1)). Multiple regression analysis revealed a relationship between capillary Lp and systemic red blood cell concentration or hematocrit, plasma protein concentration, and Δτ (Test Subgroup 1, R(2) = 0.59, P healthy state. Recovering barrier function may be an unrecognized benefit of transfusions during blood loss or edema formation. © 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

  4. An LP-based heuristic for the fixed charge transportation problem

    DEFF Research Database (Denmark)

    Klose, Andreas

    2007-01-01

    The fixed charge transportation problem consists in finding a minimum cost network flow from a set of suppliers to a set of customers. Beside costs proportional to quantities transported, transportation costs also include a fixed charge. The paper describes a linear programming based heuristic...... approach for computing lower and upper bounds on the minimal cost. To this end, the LP relaxation is iteratively strengthened by means of adding cuts; in each iteration the current LP solution is then used to guide a local search heuristic. In addition to standard polyhedral cuts as lifted cover...

  5. Long Period (LP) volcanic earthquake source location at Merapi volcano by using dense array technics

    Science.gov (United States)

    Metaxian, Jean Philippe; Budi Santoso, Agus; Laurin, Antoine; Subandriyo, Subandriyo; Widyoyudo, Wiku; Arshab, Ghofar

    2015-04-01

    Since 2010, Merapi shows unusual activity compared to last decades. Powerful phreatic explosions are observed; some of them are preceded by LP signals. In the literature, LP seismicity is thought to be originated within the fluid, and therefore to be representative of the pressurization state of the volcano plumbing system. Another model suggests that LP events are caused by slow, quasi-brittle, low stress-drop failure driven by transient upper-edifice deformations. Knowledge of the spatial distribution of LP events is fundamental for better understanding the physical processes occurring in the conduit, as well as for the monitoring and the improvement of eruption forecasting. LP events recorded at Merapi have a spectral content dominated by frequencies between 0.8 and 3 Hz. To locate the source of these events, we installed a seismic antenna composed of 4 broadband CMG-6TD Güralp stations. This network has an aperture of 300 m. It is located on the site of Pasarbubar, between 500 and 800 m from the crater rim. Two multi-parameter stations (seismic, tiltmeter, S-P) located in the same area, equipped with broadband CMG-40T Güralp sensors may also be used to complete the data of the antenna. The source of LP events is located by using different approaches. In the first one, we used a method based on the measurement of the time delays between the early beginnings of LP events for each array receiver. The observed differences of time delays obtained for each pair of receivers are compared to theoretical values calculated from the travel times computed between grid nodes, which are positioned in the structure, and each receiver. In a second approach, we estimate the slowness vector by using MUSIC algorithm applied to 3-components data. From the slowness vector, we deduce the back-azimuth and the incident angle, which give an estimation of LP source depth in the conduit. This work is part of the Domerapi project funded by French Agence Nationale de la Recherche (https

  6. Association of carotid plaque Lp-PLA(2 with macrophages and Chlamydia pneumoniae infection among patients at risk for stroke.

    Directory of Open Access Journals (Sweden)

    Berna Atik

    Full Text Available BACKGROUND: We previously showed that the burden of Chlamydia pneumoniae in carotid plaques was significantly associated with plaque interleukin (IL-6, and serum IL-6 and C-reactive protein (CRP, suggesting that infected plaques contribute to systemic inflammatory markers in patients with stroke risk. Since lipoprotein-associated phospholipase A2 (Lp-PLA(2 mediates inflammation in atherosclerosis, we hypothesized that serum Lp-PLA(2 mass and activity levels and plaque Lp-PLA(2 may be influenced by plaque C. pneumoniae infection. METHODOLOGY/PRINCIPAL FINDINGS: Forty-two patients underwent elective carotid endarterectomy. Tissue obtained at surgery was stained by immunohistochemistry for Lp-PLA(2 grade, macrophages, IL-6, C. pneumoniae and CD4+ and CD8+ cells. Serum Lp-PLA(2 activity and mass were measured using the colorimetric activity method (CAM and ELISA, respectively. Serum homocysteine levels were measured by HPLC. Eleven (26.2% patients were symptomatic with transient ischemic attacks. There was no correlation between patient risk factors (smoking, coronary artery disease, elevated cholesterol, diabetes, obesity, hypertension and family history of genetic disorders for atherosclerosis and serum levels or plaque grade for Lp-PLA(2. Plaque Lp-PLA(2 correlated with serum homocysteine levels (p = 0.013, plaque macrophages (p<0.01, and plaque C. pneumoniae (p<0.001, which predominantly infected macrophages, co-localizing with Lp-PLA(2. CONCLUSIONS: The significant association of plaque Lp-PLA(2 with plaque macrophages and C. pneumoniae suggests an interactive role in accelerating inflammation in atherosclerosis. A possible mechanism for C. pneumoniae in the atherogenic process may involve infection of macrophages that induce Lp-PLA(2 production leading to upregulation of inflammatory mediators in plaque tissue. Additional in vitro and in vivo research will be needed to advance our understanding of specific C. pneumoniae and Lp-PLA(2

  7. 77 FR 77122 - Pyxis Capital, L.P., et al.;

    Science.gov (United States)

    2012-12-31

    ... basis, and will be subject to a Transaction Fee. 13. Neither the Trust nor any Fund will be advertised or marketed or otherwise held out as a traditional open-end investment company or mutual fund... and/or service fees charged with respect to shares of an Acquiring Fund will not exceed the limits...

  8. Lp-valued stochastic convolution integral driven by Volterra noise

    Czech Academy of Sciences Publication Activity Database

    Čoupek, P.; Maslowski, B.; Ondreját, Martin

    2018-01-01

    Roč. 18, č. 6 (2018), č. článku 1850048. ISSN 0219-4937 R&D Projects: GA ČR(CZ) GA15-08819S Institutional support: RVO:67985556 Keywords : Volterra process * Rosenblatt process * hypercontractivity Subject RIV: BA - General Mathematics Impact factor: 0.820, year: 2016

  9. 75 FR 8921 - Grant of Authority for Subzone Status; Brightpoint North America L.P. (Cell Phone Kitting and...

    Science.gov (United States)

    2010-02-26

    ... authority to establish a special-purpose subzone at the cell phone kitting and distribution facilities of... kitting and distribution of cell phones at the facilities of Brightpoint North America L.P., located in... Foreign-Trade Zones Board Grant of Authority for Subzone Status; Brightpoint North America L.P. (Cell...

  10. 75 FR 39244 - Arizona Public Service Company, Sequent Energy Management, L.P.; Notice of Joint Petition for...

    Science.gov (United States)

    2010-07-08

    ... Energy Regulatory Commission Arizona Public Service Company, Sequent Energy Management, L.P.; Notice of... notice that on June 25, 2010, Arizona Public Service Company and Sequent Energy Management, L.P. filed...://www.ferc.gov , using the ``eLibrary'' link and is available for review in the Commission's Public...

  11. 75 FR 49926 - Arena Energy, L.P. v. Sea Robin Pipeline Company, LLC; Notice of Complaint

    Science.gov (United States)

    2010-08-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Arena Energy, L.P. v. Sea Robin Pipeline Company, LLC; Notice of Complaint... Commission's (Commission) Rules of Practice and Procedure, 18 CFR 385.206 (2010), Arena Energy, L.P...

  12. Prenatal exposure to a maternal LP diet decreases BDNF expression in the brains of the neonatal offspring

    Science.gov (United States)

    Maternal low protein (LP) diets during gestation cause learning and mernmy impai1ment as well as cognitive deficits in the neonatal and adult offsp1ing. The cellular and molecular mechanism that mediate the deleterious effects of prenatal exposure to a maternal LP diet on cognitive function is egreg...

  13. 75 FR 56093 - Eagle Rock Desoto Pipeline, LP; Notice of Motion for Extension of Rate Case Filing Deadline

    Science.gov (United States)

    2010-09-15

    ... Energy Regulatory Commission Eagle Rock Desoto Pipeline, LP; Notice of Motion for Extension of Rate Case Filing Deadline September 8, 2010. Take notice that on September 8, 2010, Eagle Rock Desoto Pipeline, L.P. (Eagle Rock) filed a request to extend the date for filing its next rate case to May 1, 2012. Eagle Rock...

  14. 76 FR 22695 - Yuba City Cogenerations Partners, LP; Supplemental Notice That Initial Market-Based Rate Filing...

    Science.gov (United States)

    2011-04-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Yuba City Cogenerations Partners, LP; Supplemental Notice That Initial... notice in the above-referenced proceeding of Yuba City Cogeneration Partners, LP's application for market...

  15. 78 FR 338 - Buckeye Hammond Railroad, L.L.C.; Acquisition and Operation Exemption; Buckeye Partners, L.P.

    Science.gov (United States)

    2013-01-03

    ...] Buckeye Hammond Railroad, L.L.C.; Acquisition and Operation Exemption; Buckeye Partners, L.P. Buckeye Hammond Railroad, L.L.C. (BHRR), a noncarrier, has filed a verified notice of exemption under 49 CFR 1150.31 \\1\\ to acquire from Buckeye Partners, L.P., a noncarrier, and to operate approximately 6,797 feet...

  16. Unge indvandrere på kontanthjælp i Københavns kommune: Barrierer for uddannelse og arbejde

    DEFF Research Database (Denmark)

    Pico Geerdsen, Lars; Jakobsen, Vibeke

    I dette arbejdspapir undersøges, hvilke barrierer for uddannelse og beskæftigelse, der eksisterer for unge indvandrere på kontanthjælp i Københavns Kommune. I undersøgelsen gives en karakteristik af de unge indvandrere på kontanthjælp. Desuden analyseres deres kontakt med aktiveringssystemet og e...

  17. 76 FR 36910 - Astoria Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas...

    Science.gov (United States)

    2011-06-23

    ... Energy Regulatory Commission Astoria Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas Turbine Power LLC, Dunkirk Power LLC, Huntley Power LLC, Oswego Harbor Power LLC, TC... that on June 15, 2011, Astoria Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC...

  18. 76 FR 34692 - Astoria Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas...

    Science.gov (United States)

    2011-06-14

    ... Energy Regulatory Commission Astoria Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas Turbine Power LLC, Dunkirk Power LLC, Huntley Power LLC, Oswego Harbor Power LLC, TC... (Commission), 18 CFR 385.206 (2011), Astoria Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill...

  19. 78 FR 4842 - Linden VFT, LLC v. Brookfield Energy Marketing, LP, Cargill Power Markets, LLC; Notice of Complaint

    Science.gov (United States)

    2013-01-23

    ... Energy Regulatory Commission Linden VFT, LLC v. Brookfield Energy Marketing, LP, Cargill Power Markets... 206 and 306 of the Federal Power Act, 16 U.S.C. 824(e) and 825(e), Linden VFT, LLC (Complainant) filed a formal complaint against Brookfield Energy Marketing, LP and Cargill Power Markets, LLC...

  20. 77 FR 60430 - Brigham Oil & Gas, L.P.; Notice for Temporary Waiver of Filing and Reporting Requirements

    Science.gov (United States)

    2012-10-03

    ... Federal Energy Regulatory Commission Brigham Oil & Gas, L.P.; Notice for Temporary Waiver of Filing and... Rules of Practice and Procedure, 18 CFR 385.204 (2012), Brigham Oil & Gas, L.P., (Brigham Oil & Gas.... Brigham Oil & Gas requested review on an expedited basis and that a Commission order granting the...

  1. Estimating the Population Impact of Lp(a) Lowering on the Incidence of Myocardial Infarction and Aortic Stenosis

    DEFF Research Database (Denmark)

    Afshar, Mehdi; Kamstrup, Pia R; Williams, Ken

    2016-01-01

    OBJECTIVE: High lipoprotein(a) (Lp[a]) is the most common genetic dyslipidemia and is a causal factor for myocardial infarction (MI) and aortic stenosis (AS). We sought to estimate the population impact of Lp(a) lowering that could be achieved in primary prevention using the therapies in developm...

  2. 75 FR 76317 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2010-12-08

    ... Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd... Israel (CAAI), which is the aviation authority for Israel, has issued Israeli Airworthiness Directive 28... Israel Aircraft Industries, Ltd.): Docket No. FAA-2010-1164; Directorate Identifier 2010-NM-057-AD...

  3. 75 FR 57844 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2010-09-23

    ... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Model Galaxy and... Held by Israel Aircraft Industries, Ltd.): Amendment 39-16438. Docket No. FAA-2010-0555; Directorate... Certificate previously held by Israel Aircraft Industries, Ltd.) Model Galaxy and Gulfstream 200 airplanes...

  4. 77 FR 32069 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2012-05-31

    ... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Airplanes AGENCY... previously held by Israel Aircraft Industries, Ltd.) Model Galaxy and Gulfstream 200 airplanes. This proposed... receive about this proposed AD. Discussion The Civil Aviation Authority of Israel (CAAI), which is the...

  5. 77 FR 58323 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2012-09-20

    ... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Airplanes AGENCY... Previously Held by Israel Aircraft Industries, Ltd.) Model Gulfstream G150 airplanes. This proposed AD was... Israel (CAAI), which is the aviation authority for Israel, has issued Israeli Airworthiness Directive 01...

  6. 75 FR 36296 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2010-06-25

    ... Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd... The Civil Aviation Authority of Israel (CAAI), which is the aviation authority for Israel, has issued... Previously Held by Israel Aircraft Industries, Ltd.): Docket No. FAA-2010-0555; Directorate Identifier 2010...

  7. 78 FR 47546 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2013-08-06

    ... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Airplanes AGENCY... Certificate Previously Held by Israel Aircraft Industries, Ltd.) Model Gulfstream 100 airplanes, and Model... of Israel (CAAI), which is the aviation authority for Israel, has issued Israeli Airworthiness...

  8. 78 FR 35263 - Freeport LNG Development, L.P.; Application for Blanket Authorization To Export Previously...

    Science.gov (United States)

    2013-06-12

    ... the LNG at the time of export. The Application was filed under section 3 of the Natural Gas Act (NGA... not prohibited by U.S. law or policy. Current Application The current Application is filed in... Freeport LNG Development, L.P.; Application for Blanket Authorization To Export Previously Imported...

  9. State of the Art in LP-WAN Solutions for Industrial IoT Services

    Directory of Open Access Journals (Sweden)

    Ramon Sanchez-Iborra

    2016-05-01

    Full Text Available The emergence of low-cost connected devices is enabling a new wave of sensorization services. These services can be highly leveraged in industrial applications. However, the technologies employed so far for managing this kind of system do not fully cover the strict requirements of industrial networks, especially those regarding energy efficiency. In this article a novel paradigm, called Low-Power Wide Area Networking (LP-WAN, is explored. By means of a cellular-type architecture, LP-WAN–based solutions aim at fulfilling the reliability and efficiency challenges posed by long-term industrial networks. Thus, the most prominent LP-WAN solutions are reviewed, identifying and discussing the pros and cons of each of them. The focus is also on examining the current deployment state of these platforms in Spain. Although LP-WAN systems are at early stages of development, they represent a promising alternative for boosting future industrial IIoT (Industrial Internet of Things networks and services.

  10. 76 FR 57087 - Stone Harbor Investment Partners LP, et al.; Notice of Application

    Science.gov (United States)

    2011-09-15

    ..., or cause more than 10% of the acquired company's voting stock to be owned by investment companies and... COMMISSION Stone Harbor Investment Partners LP, et al.; Notice of Application September 7, 2011. AGENCY... the Investment Company Act of 1940 (``Act'') for an exemption from rule 12d1-2(a) under the Act...

  11. 77 FR 71585 - Brookfield Energy Marketing LP v. ISO New England Inc.; Notice of Complaint

    Science.gov (United States)

    2012-12-03

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Brookfield Energy Marketing LP v. ISO New England Inc.; Notice of... Procedure of the Federal Energy Regulatory Commission (Commission), 18 CFR 385.206 and sections 206 and 306...

  12. 76 FR 66618 - Airworthiness Directives; Eurocopter France (Eurocopter) Model EC225LP Helicopters

    Science.gov (United States)

    2011-10-27

    ...-43-AD; Amendment 39-16815; AD 2011-20-05] RIN 2120-AA64 Airworthiness Directives; Eurocopter France (Eurocopter) Model EC225LP Helicopters AGENCY: Federal Aviation Administration, DOT. ACTION: Final rule... directive to read as follows: 2011-20-05 Eurocopter France (Eurocopter): Amendment 39-16815; Docket No. FAA...

  13. 76 FR 66613 - Airworthiness Directives; Eurocopter France (Eurocopter) Model EC225LP Helicopters

    Science.gov (United States)

    2011-10-27

    ...-028-AD; Amendment 39-16834; AD 2011-21-11] RIN 2120-AA64 Airworthiness Directives; Eurocopter France (Eurocopter) Model EC225LP Helicopters AGENCY: Federal Aviation Administration, DOT. ACTION: Final rule... amended by adding a new airworthiness directive (AD) to read as follows: 2011-21-11 Eurocopter France...

  14. A novel cold-adapted lipase, LP28, from a mesophilic Streptomyces strain.

    Science.gov (United States)

    Simkhada, Jaya Ram; Yoo, Hah Young; Cho, Seung Sik; Choi, Yun Hee; Kim, Seung Wook; Park, Don Hee; Yoo, Jin Cheol

    2012-01-01

    Fossil fuel is limited but its usage has been growing rapidly, thus the fuel is predicted to be completely running out and causing an unbearable global energy crisis in the near future. To solve this potential crisis, incorporating with increasing environmental concerns, significant attentions have been given to biofuel production in the recent years. With the aim of isolating a microbial biocatalyst with potential application in the field of biofuel, a lipase from Streptomyces sp. CS628, LP28, was purified using hydroxyapatite column chromatography followed by a gel filtration. Molecular weight of LP28 was estimated to be 32,400 Da by SDS-PAGE. The activity was the highest at 30 °C and pH 8.0 and was stable at pH 6.0-8.0 and below 25 °C. The enzyme preferentially hydrolyzed p-nitrophenyl decanoate (C10), a medium chain substrate. Furthermore, LP28 non-specifically hydrolyzed triolein releasing both 1,2- and 1,3-diolein. More importantly, LP28 manifestly catalyzed biodiesel production using palm oil and methanol; therefore, it can be a potential candidate in the field of biofuel.

  15. Espacios $L_p$ y teoremas de convergencia para integrales vectoriales

    OpenAIRE

    Bravo de la Parra, Rafael

    1987-01-01

    This paper deals with the study of a bilinear integral, which is an extension of Bartle $^\\ast$-integral for locally convex spaces. Attention is focused on the construction of spaces $L_p$, and theorems of convergence of integrable functions.

  16. Survival associated pathway identification with group Lp penalized global AUC maximization

    Directory of Open Access Journals (Sweden)

    Liu Zhenqiu

    2010-08-01

    Full Text Available Abstract It has been demonstrated that genes in a cell do not act independently. They interact with one another to complete certain biological processes or to implement certain molecular functions. How to incorporate biological pathways or functional groups into the model and identify survival associated gene pathways is still a challenging problem. In this paper, we propose a novel iterative gradient based method for survival analysis with group Lp penalized global AUC summary maximization. Unlike LASSO, Lp (p 1. We first extend Lp for individual gene identification to group Lp penalty for pathway selection, and then develop a novel iterative gradient algorithm for penalized global AUC summary maximization (IGGAUCS. This method incorporates the genetic pathways into global AUC summary maximization and identifies survival associated pathways instead of individual genes. The tuning parameters are determined using 10-fold cross validation with training data only. The prediction performance is evaluated using test data. We apply the proposed method to survival outcome analysis with gene expression profile and identify multiple pathways simultaneously. Experimental results with simulation and gene expression data demonstrate that the proposed procedures can be used for identifying important biological pathways that are related to survival phenotype and for building a parsimonious model for predicting the survival times.

  17. 78 FR 12048 - Gulf Shore Energy Partners, LP; Notice of Abbreviated Application for Limited Amendment to...

    Science.gov (United States)

    2013-02-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Gulf Shore Energy Partners, LP; Notice of Abbreviated Application for Limited Amendment to Certificate of Public Convenience and Necessity On February 11, 2013, Gulf Shore...

  18. 76 FR 41432 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

    Science.gov (United States)

    2011-07-14

    ... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Model Galaxy, Gulfstream... actuator centering spring rod was discovered on a model G100 aircraft during a routine scheduled maintenance inspection. * * * This latent failure of a centering spring rod, if not detected and corrected, in...

  19. Norra LP-mudel ajab Eestis juuri / intervjueerinud Sirje Pärismaa

    Index Scriptorium Estoniae

    2016-01-01

    Teaduspõhise LP-mudeli (Learning environment and pedagogical analysis) - abivahendi koolikultuuri parandamiseks ja süsteemsemaks lähenemiseks tekkinud probleemidele - on kasutusele võtnud 10 kooli ja 3 lasteaeda. Norra hariduseksperdid Janne Stoen ja Hanna Jahnsen vastasid Õpetajate Lehe küsimustele

  20. TRIGONOMETRIC QUASI-GREEDY BASES FOR L-p (T; w)

    DEFF Research Database (Denmark)

    Nielsen, Morten

    2009-01-01

    We give a complete characterization of 2π-periodic weights w for which the usual trigonometric system forms a quasi-greedy basis for Lp(T;w), i.e. bases for which simple thresholding approximants converge in norm. The characterization implies that this can happen only for p=2 and whenever the sys...

  1. 78 FR 14778 - Application to Export Electric Energy; Shell Energy North America (US), L.P.

    Science.gov (United States)

    2013-03-07

    ... applicant have a franchised service area. The electric energy that Shell Energy proposes to export to Mexico... Shell Energy application to export electric energy to ] Mexico should be clearly marked with OE Docket... Application to Export Electric Energy; Shell Energy North America (US), L.P. AGENCY: Office of Electricity...

  2. 47 CFR 74.1204 - Protection of FM broadcast, FM Translator and LP100 stations.

    Science.gov (United States)

    2010-10-01

    ... LP100 stations. 74.1204 Section 74.1204 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... effective radiated power (ERP) to be used is the maximum ERP of the main radiated lobe in the pertinent... component or the horizontal component of the ERP should be used, whichever is greater in the pertinent...

  3. 78 FR 8611 - WINCO Investment Partnership 2008 L.P. and Winstead PC; Notice of Application

    Science.gov (United States)

    2013-02-06

    ... security or other property to the investment company or knowingly purchasing a security or other property... COMMISSION WINCO Investment Partnership 2008 L.P. and Winstead PC; Notice of Application January 31, 2013... under sections 6(b) and 6(e) of the Investment Company Act of 1940 (the ``Act'') granting an exemption...

  4. Weighted $L^p$ estimates for the elliptic Schrödinger operator

    Directory of Open Access Journals (Sweden)

    Fengping Yao

    2014-07-01

    Full Text Available In this paper we study weighted $L^p$ estimates for the elliptic Schrödinger operator $P=-\\Delta +V(x $ with non-negative potentials $V(x$ on $\\mathbb{R}^n~(n\\geq 3$ which belongs to certain reverse Hölder class.

  5. Serum LP(A) levels in randomized healthy men from different European countries

    NARCIS (Netherlands)

    Cigolini, M; Seidell, J C; Zenti, M G; Bonadonna, G; Zambelli, L; Deslypere, J P; Contaldo, F; Cruz, A.; Charzewska, J; Targher, G

    Serum lipoprotein(a) [Lp(a)], blood lipids, serum insulin and anthropometric parameters were determined in randomized samples of 38-year-old men living in six European cities: Ede (The Netherlands), Deinze (Belgium), Warsaw (Poland), Lumiar (Portugal), Verona and Naples (respectively in northern and

  6. Robust Granger Analysis in Lp Norm Space for Directed EEG Network Analysis.

    Science.gov (United States)

    Li, Peiyang; Huang, Xiaoye; Li, Fali; Wang, Xurui; Zhou, Weiwei; Liu, Huan; Ma, Teng; Zhang, Tao; Guo, Daqing; Yao, Dezhong; Xu, Peng

    2017-11-01

    Granger analysis (GA) is widely used to construct directed brain networks based on various physiological recordings, such as functional magnetic resonance imaging, and electroencephalogram (EEG). However, in real applications, EEGs are inevitably contaminated by unexpected artifacts that may distort the networks because of the L2 norm structure utilized in GAs when estimating directed links. Compared with the L2 norm, the Lp ( ) norm can compress outlier effects. In this paper, an extended GA is constructed by applying the Lp ( ) norm strategy to estimate robust causalities under outlier conditions, and a feasible iteration procedure is utilized to solve the new GA model. A quantitative evaluation using a predefined simulation network demonstrates smaller bias errors and higher linkage consistence for the Lp ( , 0.8, 0.6, 0.4, 0.2) -GAs compared with both the Lasso- and L2-GAs under various simulated outlier conditions. Applications in resting-state EEGs that contain ocular artifacts also show that the proposed GA can effectively compress the ocular outlier influence and recover the reliable networks. The proposed Lp-GA may be helpful in capturing the reliable network structure when EEGs are contaminated with artifacts in related studies.

  7. Harried LP-gas marketers recount the recent price/supply nightmare

    Energy Technology Data Exchange (ETDEWEB)

    Prowler, S

    1990-02-01

    This article presents a survey of several LP-gas marketers, who discuss how their companies responded to the propane fuel crisis during the winter of 1989-1990. wholesale and retail pricing, as well as consumer response during this period are described. Supply strategies for the future are discussed.

  8. Serum Lp-PLA2: as a novel viewpoint in periodontal treatment of hyperlipidaemics.

    Science.gov (United States)

    Fentoğlu, Özlem; Kirzioğlu, Fatma Yeşim; Tözüm Bulut, Memduha; Kurgan, Şivge; Koçak, Havva; Sütcü, Recep; Kale Köroğlu, Banu; Günhan, Meral

    2015-01-01

    To evaluate the effects of periodontal treatment on serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and C-reactive protein (CRP) levels in hyperlipidaemic patients with periodontitis. The study included 52 hyperlipidaemics and 28 systemically healthy controls (C) with periodontitis. Of the 52 hyperlipidaemics, 29 received a suggested diet (HD), and 23 of them were prescribed statin (HS). Clinical periodontal parameters, serum lipids, Lp-PLA2, and CRP levels were assessed at the baseline and 2 months after the completion of the nonsurgical periodontal treatment (2MPT). Serum parameters were also evaluated 1 week following the periodontal treatment (1WPT). At the baseline, patients in the HS group had a higher percentage of bleeding on probing than those in the C and HD groups. Hyperlipidaemics had higher serum triglyceride levels than the control group at 2MPT compared to the baseline. At 2MPT, the levels of Lp-PLA2 in the HS group were significantly higher compared to the baseline and 1WPT. There were no statistically significant differences in CRP levels between study periods for all groups. The periodontal treatment may affect the inflammatory control of hyperlipidaemic patients with periodontitis via increased Lp-PLA2 levels and severity of the impaired lipid metabolism. These findings may be important regarding the therapeutic strategies for hyperlipidaemics with periodontitis.

  9. 76 FR 65507 - Notice of Petition for Rate Approval; Eagle Ford Midstream, LP

    Science.gov (United States)

    2011-10-21

    ... Energy Regulatory Commission Notice of Petition for Rate Approval; Eagle Ford Midstream, LP Take notice that on October 11, 2011, (Eagle Ford) filed a petition for rate approval pursuant to section 284.123(b.... Eagle Ford states that it is an existing intrastate pipeline, within the meaning of sections 2(16) and...

  10. Måling af friktion ved hjælp af spindelpressen

    DEFF Research Database (Denmark)

    Henningsen, Poul

    Teknisk Manual. Denne rapport gennemgår forsøgsopstillinger på spindelpressen til måling af friktion. Der bliver kort gennemgået hvilket udstyr der skal bruges, og hvordan data opsamles og transducerne kalibreres. Rapporten er en hjælp til opstilling af udstyret. Beskrivelser af testprincipper og...

  11. 76 FR 65717 - Erie Boulevard Hydropower, L.P.; Notice of Availability of Environmental Assessment

    Science.gov (United States)

    2011-10-24

    ... Energy Regulatory Commission Erie Boulevard Hydropower, L.P.; Notice of Availability of Environmental Assessment In accordance with the National Environmental Policy Act of 1969 and the Federal Energy Regulatory... has prepared an Environmental Assessment (EA) for the project. The project does not occupy any federal...

  12. 76 FR 46287 - Erie Boulevard Hydropower, L.P.; Notice of Availability of Environmental Assessment

    Science.gov (United States)

    2011-08-02

    ... Energy Regulatory Commission Erie Boulevard Hydropower, L.P.; Notice of Availability of Environmental Assessment In accordance with the National Environmental Policy Act of 1969 and the Federal Energy Regulatory... environmental assessment (EA). The project is located on the Sacandaga River in Saratoga County, New York. The...

  13. State of the Art in LP-WAN Solutions for Industrial IoT Services.

    Science.gov (United States)

    Sanchez-Iborra, Ramon; Cano, Maria-Dolores

    2016-05-17

    The emergence of low-cost connected devices is enabling a new wave of sensorization services. These services can be highly leveraged in industrial applications. However, the technologies employed so far for managing this kind of system do not fully cover the strict requirements of industrial networks, especially those regarding energy efficiency. In this article a novel paradigm, called Low-Power Wide Area Networking (LP-WAN), is explored. By means of a cellular-type architecture, LP-WAN-based solutions aim at fulfilling the reliability and efficiency challenges posed by long-term industrial networks. Thus, the most prominent LP-WAN solutions are reviewed, identifying and discussing the pros and cons of each of them. The focus is also on examining the current deployment state of these platforms in Spain. Although LP-WAN systems are at early stages of development, they represent a promising alternative for boosting future industrial IIoT (Industrial Internet of Things) networks and services.

  14. Efficacy and Safety of Lactobacillus plantarum DSM 9843 (LP299V) in the Prevention of Antibiotic-Associated Gastrointestinal Symptoms in Children-Randomized, Double-Blind, Placebo-Controlled Study.

    Science.gov (United States)

    Olek, Agnieszka; Woynarowski, Marek; Ahrén, Irini Lazou; Kierkuś, Jarosław; Socha, Piotr; Larsson, Niklas; Önning, Gunilla

    2017-07-01

    To determine if Lactobacillus plantarum DSM9843 (LP299V) reduces the frequency of antibiotic-associated loose/watery stools and gastrointestinal symptoms, and can be administered safely to children who are prescribed antibiotics. We performed a prospective, double-blind, randomized, placebo-controlled, multicenter, parallel-group study in children receiving outpatient antibiotic therapy in primary healthcare settings. The children were given LP299V/placebo during the antibiotic therapy and for 1 week after the end of treatment. The primary outcome measure was the incidence of at least 1 loose/watery stool (type 6 or 7 according to the Bristol Stool Form Scale). Gastrointestinal symptoms (abdominal pain, abdominal distention, vomiting, and flatulence) were followed up until 1 week after the last intake of the study product. A total of 438 children (male: 235, female: 203) aged 1-11 years (mean ± SD: 5.2 ± 2.7) were randomized to receive LP299V (N = 218) or placebo (N = 220). The incidence of loose/watery stools in the 2 study groups (LP299V and placebo) was similar, 39% vs 44.5% respectively (P = .26) as was the mean number of loose/watery stools (3.9 ± 3.5 vs 4.7 ± 6.3; P = .9). Antibiotic-associated diarrhea (defined as ≥3 loose/watery stools/24 hours starting from 2 hours after initiation of antibiotic treatment until the end of the study) occurred in 2.8% of the subjects receiving LP299V compared with 4.1% in the placebo arm (P = .4). The number of children with abdominal symptoms did not differ between the groups. No beneficial effect of LP299V compared with placebo was observed for the incidence of loose/watery stools, mean number of loose/watery stools, or the incidence of abdominal symptoms. LP299V had a satisfactory safety profile. ClinicalTrials.gov: NCT01940913. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. The effect of an inhibitor of gut serotonin (LP533401) during the induction of periodontal disease.

    Science.gov (United States)

    Lima, G M G; Corazza, B J M; Moraes, R M; de Oliveira, F E; de Oliveira, L D; Franco, G C N; Perrien, D S; Elefteriou, F; Anbinder, A L

    2016-10-01

    LP533401 is an inhibitor of tryptophan hydroxylase 1, which regulates serotonin production in the gut. Previous work indicates that LP533401 has an anabolic effect in bone. Thus, we hypothesized that inhibition of gut serotonin production may modulate the host response in periodontal disease. In this study, we aimed to analyze the effects of LP533401 in a rat periodontitis model to evaluate the role of gut serotonin in periodontitis pathophysiology. Twenty-four rats were divided into three groups: treated group (T: ligature-induced periodontal disease and LP533401, 25 mg/kg/d) by gavage; ligature group (L: ligature-induced periodontal disease only); and control group (C: without ligature-induced periodontal disease). After 28 d, radiographic alveolar bone support was measured on digital radiographs, and alveolar bone volume fraction, tissue mineral density and trabeculae characteristics were quantified by microcomputed tomography in the right hemi-mandible. Left hemi-mandibles were decalcified and alveolar bone loss, attachment loss and area of collagen in the gingiva were histologically analyzed. Significant difference between the L and C groups was found, confirming that periodontal disease was induced. We observed no difference between the T and L groups regarding alveolar bone destruction and area of collagen. LP533401 (25 mg/kg/d) for 28 d does not prevent bone loss and does not modulate host response in a rat model of induced periodontal disease. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  16. [Association between genotype and allele frequencies of CYP2A6*12 and rs16969968 in CHRNA5 variants with smoking and body mass index in young subjects from Northeast Mexico].

    Science.gov (United States)

    Borrego-Soto, Gissela; Costilla-Esquivel, Antonio; Padilla-Rivas, Gerardo Raymundo; Cázares-Samaniego, Paulina Janeth; Posadas-Valay, Rodolfo; Velasco-Castañón, José Gerardo; Mercado-Longoria, Roberto; Ortiz-López, Rocío; Rojas-Martínez, Augusto

    2015-11-01

    Several studies have reported that variants rs16969968 G>A of the CHRNA5 gene and CYP2A6*12 of the CYP2A6 gene are associated with smoking and smoking refusal, respectively. In addition, some studies report that a higher cigarette consumption is associated with low body mass index (BMI). To analyze the allele and genotypic frequencies of these variants and their impact on smoking and BMI. A blood sample was obtained and a survey about smoking habits was answered by 319 university students aged 18 to 35 years (127 women, 171 smokers), living in Northeastern Mexico. Genetic variants were studied by polymerase chain reaction/restriction fragment length polymorphism and their frequencies were associated with smoking and BMI. No associations were found between the analyzed variants and smoking in the study groups. However, there was an association among non-smoking subjects between the A allele of rs16969968 and high a BMI (p food-addiction disorders.

  17. Concomitant effects of Ramadan fasting and time-of-day on apolipoprotein AI, B, Lp-a and homocysteine responses during aerobic exercise in Tunisian soccer players.

    Directory of Open Access Journals (Sweden)

    Omar Hammouda

    Full Text Available OBJECTIVE: To examine the time-of-day and Ramadan fasting (RF effects on serum apolipoprotein-AI (Apo-AI and B (Apo-B, lipoprotein particles-a (Lp-a, high-sensitive C-reactive-protein (hs-CRP, and homocysteine (Hcy during the Yo-Yo intermittent recovery test (YYIRT. DESIGN: Performance and biochemical measures were completed at two times-of-day (07:00 and 17:00 h, 1-week before RF (BR, the second week of RF (SWR, and the fourth week of RF (ER. SETTING: For each session, subjects performed the YYIRT, and blood samples were taken before and 3-min after the test for biochemical measures. PARTICIPANTS: Fifteen soccer players. MAIN OUTCOME MEASURES: Total distance during the YYIRT, core temperature, body composition, dietary intakes, lipid (HDL-C, LDL-C, Apo-AI, B and Lp-a and inflammatory (hs-CRP and Hcy profiles. RESULTS: Performances during the YYIRT were higher in the evening than the morning BR (P < 0.05, but this fluctuation was not observed during RF. Moreover, LDL-C, ApoB, and Lp-a were stable throughout the daytime BR. However, during RF, they decreased at 17:00 h (P < 0.05. Likewise, HDL-C and Apo-AI increased after the exercise and were higher at 17:00 h BR (P < 0.001. Moreover, these parameters increased during RF (P < 0.01. Furthermore, Hcy and hs-CRP increased during the exercise (P < 0.01 with higher evening levels BR. During ER, the diurnal pattern of Hcy was inversed (P < 0.001. CONCLUSIONS: This study concluded that caloric restriction induced by RF seems to ameliorate lipid and inflammatory markers of cardiovascular health during intermittent exercise performed in the evening.

  18. 77 FR 74544 - Eagle Fund III, L.P., License No. 07/07-0116; Notice Seeking Exemption Under Section 312 of the...

    Science.gov (United States)

    2012-12-14

    ... ADMINISTRATION Eagle Fund III, L.P., License No. 07/07-0116; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that Eagle Fund III, L.P... interest, of the Small Business Administration Rules and Regulations (13 CFR part 107). Eagle Fund III, L.P...

  19. New Concepts in Indexing *

    Science.gov (United States)

    Shank, Russell

    1965-01-01

    Recent trends in indexing emphasize mechanical, not intellectual, developments. Mechanized operations have produced indexes in depth (1) of information on limited areas of science or (2) utilizing limited parameters for analysis. These indexes may include only citations or both useful data and citations of source literature. Both keyword-in-context and citation indexing seem to be passing the test of the marketplace. Mechanical equipment has also been successfully used to manipulate EAM cards for production of index copy. Information centers are increasingly being used as control devices in narrowly defined subject areas. Authors meet growing pressures to participate in information control work by preparing abstracts of their own articles. Mechanized image systems persist, although large systems are scarce and the many small systems may bring only limited relief for information control and retrieval problems. Experimentation and limited development continue on theory and technique of automatic indexing and abstracting. PMID:14306025

  20. Transcriptome analysis of the epidermis of the purple quail-like (q-lp) mutant of silkworm, Bombyx mori.

    Science.gov (United States)

    Wang, Pingyang; Qiu, Zhiyong; Xia, Dingguo; Tang, Shunming; Shen, Xingjia; Zhao, Qiaoling

    2017-01-01

    A new purple quail-like (q-lp) mutant found from the plain silkworm strain 932VR has pigment dots on the epidermis similar to the pigment mutant quail (q). In addition, q-lp mutant larvae are inactive, consume little and grow slowly, with a high death rate and other developmental abnormalities. Pigmentation of the silkworm epidermis consists of melanin, ommochrome and pteridine. Silkworm development is regulated by ecdysone and juvenile hormone. In this study, we performed RNA-Seq on the epidermis of the q-lp mutant in the 4th instar during molting, with 932VR serving as the control. The results showed 515 differentially expressed genes, of which 234 were upregulated and 281 downregulated in q-lp. BLASTGO analysis indicated that the downregulated genes mainly encode protein-binding proteins, membrane components, oxidation/reduction enzymes, and proteolytic enzymes, whereas the upregulated genes largely encode cuticle structural constituents, membrane components, transport related proteins, and protein-binding proteins. Quantitative reverse transcription PCR was used to verify the accuracy of the RNA-Seq data, focusing on key genes for biosynthesis of the three pigments and chitin as well as genes encoding cuticular proteins and several related nuclear receptors, which are thought to play key roles in the q-lp mutant. We drew three conclusions based on the results: 1) melanin, ommochrome and pteridine pigments are all increased in the q-lp mutant; 2) more cuticle proteins are expressed in q-lp than in 932VR, and the number of upregulated cuticular genes is significantly greater than downregulated genes; 3) the downstream pathway regulated by ecdysone is blocked in the q-lp mutant. Our research findings lay the foundation for further research on the developmental changes responsible for the q-lp mutant.

  1. LP-search and its use in analysis of the accuracy of control systems with acoustical models

    Science.gov (United States)

    Sergeyev, V. I.; Sobol, I. M.; Statnikov, R. B.; Statnikov, I. N.

    1973-01-01

    The LP-search is proposed as an analog of the Monte Carlo method for finding values in nonlinear statistical systems. It is concluded that: To attain the required accuracy in solution to the problem of control for a statistical system in the LP-search, a considerably smaller number of tests is required than in the Monte Carlo method. The LP-search allows the possibility of multiple repetitions of tests under identical conditions and observability of the output variables of the system.

  2. Differential Gene Expression of TRPM1, the Potential Cause of Congenital Stationary Night Blindness and Coat Spotting Patterns (LP) in the Appaloosa Horse (Equus caballus)

    Science.gov (United States)

    Bellone, Rebecca R.; Brooks, Samantha A.; Sandmeyer, Lynne; Murphy, Barbara A.; Forsyth, George; Archer, Sheila; Bailey, Ernest; Grahn, Bruce

    2008-01-01

    The appaloosa coat spotting pattern in horses is caused by a single incomplete dominant gene (LP). Homozygosity for LP (LP/LP) is directly associated with congenital stationary night blindness (CSNB) in Appaloosa horses. LP maps to a 6-cM region on ECA1. We investigated the relative expression of two functional candidate genes located in this LP candidate region (TRPM1 and OCA2), as well as three other linked loci (TJP1, MTMR10, and OTUD7A) by quantitative real-time RT–PCR. No large differences were found for expression levels of TJP1, MTMR10, OTUD7A, and OCA2. However, TRPM1 (Transient Receptor Potential Cation Channel, Subfamily M, Member 1) expression in the retina of homozygous appaloosa horses was 0.05% the level found in non-appaloosa horses (R = 0.0005). This constitutes a >1800-fold change (FC) decrease in TRPM1 gene expression in the retina (FC = −1870.637, P = 0.001) of CSNB-affected (LP/LP) horses. TRPM1 was also downregulated in LP/LP pigmented skin (R = 0.005, FC = −193.963, P = 0.001) and in LP/LP unpigmented skin (R = 0.003, FC = −288.686, P = 0.001) and was downregulated to a lesser extent in LP/lp unpigmented skin (R = 0.027, FC = −36.583, P = 0.001). TRP proteins are thought to have a role in controlling intracellular Ca2+ concentration. Decreased expression of TRPM1 in the eye and the skin may alter bipolar cell signaling as well as melanocyte function, thus causing both CSNB and LP in horses. PMID:18660533

  3. Efficacy and safety of the probiotic Lactobacillus paracasei LP-33 in allergic rhinitis

    DEFF Research Database (Denmark)

    Costa, D J; Marteau, P; Amouyal, M

    2014-01-01

    BACKGROUND/OBJECTIVES: An imbalance between Th1 and Th2 cells is involved in allergic rhinitis (AR) that may be improved by probiotics. To test the efficacy of the probiotic Lactobacillus paracasei subsp. paracasei LP-33, a double-blind, placebo-controlled, randomized trial was carried out......). All received loratadine for 5 weeks. The primary end point was the improvement in Rhinitis Quality of Life (RQLQ) global score at the fifth week of LP-33 consumption compared with placebo (in addition to loratadine). Secondary end points included nasal and ocular symptoms (individual and total symptom......=-0.286 (95% confidence interval (CI): -0.536; -0.035)). No significant differences were noted for the change of the rhinitis total symptom score 5 global score between groups (P=0.1288, difference=-0.452 (95% CI: -1.036; 0.132)). Significant differences in ocular symptoms (RQLQ) were observed between...

  4. Switchable narrow linewidth fiber laser with LP11 transverse mode output

    Science.gov (United States)

    Shen, Ya; Ren, Guobin; Yang, Yuguang; Yao, Shuzhi; Wu, Yue; Jiang, Youchao; Xu, Yao; Jin, Wenxing; Zhu, Bofeng; Jian, Shuisheng

    2018-01-01

    We experimentally demonstrate a switchable narrow linewidth single-longitudinal-mode (SLM) erbium-doped fiber (EDF) ring laser with LP11 transverse mode output. The laser is based on a mode selective all-fiber fused coupler which is composed of a single-mode fiber (SMF) and a two-mode fiber (TMF). By controlling the polarization state of the output light, the laser can provide narrow linewidth SLM output with LP11 transverse mode at two specific wavelengths, which correspond to two transmission peaks of the chirped moiré fiber grating (CMFBG). The 20 dB linewidth of the fiber laser for each wavelength is approximately 7.2 and 6.4 kHz.

  5. Comportamiento de proporciones divinas e índice de Bolton en mediciones dentales de individuos con maloclusión Behavior of "divine" proportions and the Bolton's index in dental measurements of subjects with malocclusion

    Directory of Open Access Journals (Sweden)

    Adriana Lorenzo Uribazo

    2011-09-01

    Full Text Available Los pacientes acuden cada vez con más frecuencia a los servicios estomatológicos en busca de mejorar su aspecto estético. Uno de los métodos más polémicos para el examen de la estética lo constituyen aquellos que se basan en el empleo de la proporción divina, esto motivó a la realización de este trabajo. Se evaluó el comportamiento de las proporciones divinas en mediciones dentales de individuos con maloclusión, mediante el empleo del índice de Bolton. Se realizó un estudio descriptivo transversal en estudiantes del segundo al quinto años de la Facultad de Estomatología de La Habana, Cuba, desde el mes de enero del año 2009 al mes de enero del año 2010. Se emplearon modelos de yeso pertenecientes a 80 estudiantes de 18 a 25 años de edad. Se efectuaron mediciones de los anchos mesiodistales de los dientes y se relacionaron algunas secciones de dientes donde se identificaron los que guardaron relación de proporción divina, según la variable oclusión. Los estudiantes que presentaron maloclusión se estudiaron según la variación del índice de Bolton. En los estudiantes con maloclusión el índice de Bolton que predominó fue a favor de un mayor tamaño de los dientes anteroinferiores, con rangos de proporción divina menores de 1,60.Patients came more and more frequently to Stomatology services to improve the esthetic feature. Among the more polemic methods for esthetics examination are those based on the use of divine proportion, leading to carrying out of present paper to assess the behavior of divine proportions in the dental measurements of subjects with malocclusion using the Bolton's index. A cross-sectional and descriptive study was conducted in second to fifth years students of the Stomatology Faculty of La Habana from January, 2009 to January, 2010 using the plaster casts in 80 students aged 18 to 25. Measurements of the mesio-distal width of teeth relating some sections of them where were identified those en

  6. Théorie $L^p$ pour l'équation de Cauchy-Riemann

    OpenAIRE

    Laurent-Thiébaut, Christine

    2013-01-01

    In this paper we propose a systematic study of the Cauchy-Riemann operator in the $L^p$-setting in complex manifolds. We first consider $L^p_{loc}$-theory and then we develop an $L^p$ Andreotti-Grauert theory. Finally we consider Serre duality and its applications to the solvability of the Cauchy-Riemann equation with exact support in $L^p$-spaces.

  7. Th\\'eorie $L^p$ pour l'\\'equation de Cauchy-Riemann

    OpenAIRE

    Laurent-Thiébaut, Christine

    2013-01-01

    In this paper we propose a systematic study of the Cauchy-Riemann operator in the $L^p$-setting in complex manifolds. We first consider $L^p_{loc}$-theory and then we develop an $L^p$ Andreotti-Grauert theory. Finally we consider Serre duality and its applications to the solvability of the Cauchy-Riemann equation with exact support in $L^p$-spaces.

  8. Characteristics of a Monoacylglycerol Lipase Isolated from Pseudomonas sp. LP7315 -Hydrolysis and Synthesis of Monoglycerides

    OpenAIRE

    Sakiyama, Takaharu; Yoshimi, Tsuyoshi; Miyake, Akira; Umeoka, Midori; Tanaka, Atsushi; Ozaki, Sho; Nakanishi, Kazuhiro

    2001-01-01

    A monoacylglycerol lipase (MGL) was purified from Pseudomonas sp. LP7315 by ammonium sulfate precipitation, anion-exchange chromatography, and preparative electrophoresis. The purified enzyme was homogeneous on an SDS-polyacrylamide gel with a molecular mass of 59 kDa. Itshydrolytic activity was confirmed to be specific for monoglycerides: the enzyme did not hydrolyze diandtriglycerides. MGL was found to be stable even after l-h incubation at 65℃. The hydrolytic activity depended not only on ...

  9. A convolution type characterization for Lp - multipliers for the Heisenberg group

    Directory of Open Access Journals (Sweden)

    R. Radha

    2007-01-01

    Full Text Available It is well known that if m is an Lp - multiplier for the Fourier transform on ℝn(1

  10. Safety analysis report -- Packages LP-50 tritium package (Packaging of fissile and other radioactive materials)

    Energy Technology Data Exchange (ETDEWEB)

    Gates, A.A.; McCarthy, P.G.; Edl, J.W.; Chalfant, G.G. (comps.); Cadelli, G.

    1975-05-01

    Elemental tritium is shipped at low pressure in a stainless steel container (LP-50) surrounded by an aluminum vessel and Celotex insulation at least 4 in. thick in a steel drum. Each package contains a large quantity (greater than a Type A quantity) of nonfissile material, as defined in AECM 0529. This report provides the details of the safety analysis performed for this type container.

  11. Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression.

    Science.gov (United States)

    Delacrétaz, Aurélie; Preisig, Martin; Vandenberghe, Frederik; Saigi Morgui, Nuria; Quteineh, Lina; Choong, Eva; Gholam-Rezaee, Mehdi; Kutalik, Zoltan; Magistretti, Pierre; Aubry, Jean-Michel; von Gunten, Armin; Castelao, Enrique; Vollenweider, Peter; Waeber, Gerard; Conus, Philippe; Eap, Chin B

    2015-01-01

    Obesity development during psychotropic treatments represents a major health issue in psychiatry. Melanin-concentrating hormone receptor 2 (MCHR2) is a central receptor involved in energy homeostasis. MCHR2 shares its promoter region with MCHR2-AS1, a long antisense non-coding RNA. The aim of this study was to determine whether tagging single nucleotide polymorphisms (tSNPs) of MCHR2 and MCHR2-AS1 are associated with the body mass index (BMI) in the psychiatric and in the general population. The influence of MCHR2 and MCHR2-AS1 tSNPs on BMI was firstly investigated in a discovery psychiatric sample (n1 = 474). Positive results were tested for replication in two other psychiatric samples (n2 = 164, n3 = 178) and in two population-based samples (CoLaus, n4 = 5409; GIANT, n5 = 113809). In the discovery sample, TT carriers of rs7754794C>T had 1.08 kg/m2 (p = 0.04) lower BMI as compared to C-allele carriers. This observation was replicated in an independent psychiatric sample (-2.18 kg/m2; p = 0.009). The association of rs7754794C>T and BMI seemed stronger in subjects younger than 45 years (median of age). In the population-based sample, a moderate association was observed (-0.17 kg/m2; p = 0.02) among younger individuals (influence of MCHR2 and/or MCHR2-AS1 on obesity in psychiatric patients and on the pathophysiology of atypical depression.

  12. Concomitant effects of Ramadan fasting and time-of-day on apolipoprotein AI, B, Lp-a and homocysteine responses during aerobic exercise in Tunisian soccer players.

    Science.gov (United States)

    Hammouda, Omar; Chtourou, Hamdi; Aloui, Asma; Chahed, Henda; Kallel, Choumous; Miled, Abdelhedi; Chamari, Karim; Chaouachi, Anis; Souissi, Nizar

    2013-01-01

    To examine the time-of-day and Ramadan fasting (RF) effects on serum apolipoprotein-AI (Apo-AI) and B (Apo-B), lipoprotein particles-a (Lp-a), high-sensitive C-reactive-protein (hs-CRP), and homocysteine (Hcy) during the Yo-Yo intermittent recovery test (YYIRT). Performance and biochemical measures were completed at two times-of-day (07:00 and 17:00 h), 1-week before RF (BR), the second week of RF (SWR), and the fourth week of RF (ER). For each session, subjects performed the YYIRT, and blood samples were taken before and 3-min after the test for biochemical measures. Fifteen soccer players. Total distance during the YYIRT, core temperature, body composition, dietary intakes, lipid (HDL-C, LDL-C, Apo-AI, B and Lp-a) and inflammatory (hs-CRP and Hcy) profiles. Performances during the YYIRT were higher in the evening than the morning BR (P exercise and were higher at 17:00 h BR (P exercise (P evening levels BR. During ER, the diurnal pattern of Hcy was inversed (P exercise performed in the evening.

  13. Calling the lp_solve Linear Program Software from R, S-PLUS and Excel

    Directory of Open Access Journals (Sweden)

    Samuel E. Buttrey

    2005-05-01

    Full Text Available We present a link that allows R, S-PLUS and Excel to call the functions in the lp_solve system. lp_solve is free software (licensed under the GNU Lesser GPL that solves linear and mixed integer linear programs of moderate size (on the order of 10,000 variables and 50,000 constraints. R does not include this ability (though two add-on packages offer linear programs without integer variables, while S-PLUS users need to pay extra for the NuOPT library in order to solve these problems. Our link manages the interface between these statistical packages and lp_solve. Excel has a built-in add-in named Solver that is capable of solving mixed integer programs, but only with fewer than 200 variables. This link allows Excel users to handle substantially larger problems at no extra cost. While our primary concern has been the Windows operating system, the package has been tested on some Unix-type systems as well.

  14. The Leptospiral Antigen Lp49 is a Two-Domain Protein with Putative Protein Binding Function

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira Giuseppe,P.; Oliveira Neves, F.; Nascimento, A.; Gomes Guimaraes, B.

    2008-01-01

    Pathogenic Leptospira is the etiological agent of leptospirosis, a life-threatening disease that affects populations worldwide. Currently available vaccines have limited effectiveness and therapeutic interventions are complicated by the difficulty in making an early diagnosis of leptospirosis. The genome of Leptospira interrogans was recently sequenced and comparative genomic analysis contributed to the identification of surface antigens, potential candidates for development of new vaccines and serodiagnosis. Lp49 is a membrane-associated protein recognized by antibodies present in sera from early and convalescent phases of leptospirosis patients. Its crystal structure was determined by single-wavelength anomalous diffraction using selenomethionine-labelled crystals and refined at 2.0 Angstroms resolution. Lp49 is composed of two domains and belongs to the all-beta-proteins class. The N-terminal domain folds in an immunoglobulin-like beta-sandwich structure, whereas the C-terminal domain presents a seven-bladed beta-propeller fold. Structural analysis of Lp49 indicates putative protein-protein binding sites, suggesting a role in Leptospira-host interaction. This is the first crystal structure of a leptospiral antigen described to date.

  15. The First Photometric Investigation of the Neglected Contact Binary LP Comae

    Science.gov (United States)

    Liu, Jinzhong; Zhang, Yu; Song, Fangfang; Yang, Taozhi

    2017-10-01

    In this paper, we present the first complete photometric light curves in the B, V, and R passbands of the neglected contact binary LP Com. Based on the Wilson-Devinney code, it has been found that the LP Com is a W-type W UMa binary with a mass ratio of q={m}2/{m}1=4.36 and a contact degree of f = 21.3 ± 0.3%. By using our new times of minimum light together with those collected from the literature, we found that the observed calculated (O-C) curve shows an upward parabolic variation that corresponds to a long-term increase in the orbital period at a rate of {dP}/{dt}=+2.59× {10}-7 days yr-1. Such a long-term increase in its orbital period may be caused by a mass transfer from the less massive component to the more massive one. This indicates that LP Com is in the thermal relaxation oscillation controlled evolution stage. The presence of two dark spots on both companions was used to fit the asymmetry of the light curves. When the upward parabolic change was subtracted, the {(O-C)}2 curve reveals a cyclic variation with a period of 10.09 yr and a small amplitude of 0.0028 days. The cyclic variation was investigated by the light-time effect due to the presence of an extremely cool stellar companion.

  16. Stress Corrosion Behavior of 12Cr Martensite Steel for Steam Turbine LP Blade

    Science.gov (United States)

    Tianjian, Wang; Yubing, Pei; Zhenhuan, Gao; Hua, Fan; Gongxian, Yang

    With the development of capacity and efficiency of coal-fired thermal power plant, the length of Low Pressure (LP) last-stage blade of steam turbine became longer. Therefore, the design static stress of blade gets closer or even higher than the yield strength of material. Because of the special operation condition of LP last stage blade, the stress corrosion crack of 12Cr-Ni-Mo-V-N Martensite stainless steel may happen especially at the root of the blade where designed the highest static stress. In this paper, the stress corrosion behavior of 12Cr-Ni-Mo-V-N Martensite stainless steels used for steam turbine LP last stage blade in 3vol% NaCl solution was studied, the constant stress is about 95%, 85%, 65% and 35% of yield stress respectively and the test was lasted for 3000 hours, the stress corrosion behavior was studied and then, the effect of shot penning strengthen for anti-stress corrosion property of 12Cr-Ni-Mo-V-N Martensitic steel was studied. The results showed that the purity of steel affects the stress corrosion behavior huge especially at the high and medium stress condition. The shot penning cannot enhances the anti-stress corrosion property of the 12Cr-Ni-Mo-V-N steel at high tensile constant stress condition, however it will make the anti-stress corrosion property better when the stress is low.

  17. SCIAMACHY stratospheric aerosol extinction profile retrieval using the OMPS/LP algorithm

    Directory of Open Access Journals (Sweden)

    G. Taha

    2011-03-01

    Full Text Available The Ozone Mapper and Profiler Suite, Limp Profiler (OMPS/LP algorithm is used to retrieve ozone concentration and aerosol extinction profiles using a series of 120 SCIAMACHY limb measurements collocated with SAGE II solar occultation events. The primary goal of the study is to ascertain the capability of the OMPS/LP retrieval algorithm to accurately retrieve the vertical distribution of stratospheric aerosol extinction coefficient so as to better account for aerosol effects in the ozone profiling retrieval process. Using simulated radiances, we show that the aerosol extinction coefficient can be retrieved from limb scatter measurements within 5% and a standard deviation better than 15%, which is more than sufficient to improve the OMPS/LP ozone products to be used as Environmental Data Records. We also illustrate the ability of SCIAMACHY limb measurements to retrieve stratospheric aerosol extinction profiles with accuracy comparable to other instruments. The retrieved aerosol extinction profiles agree with collocated SAGE II measurements on average to within 25%, with a standard deviation of 35%.

  18. Gene therapy for hemophilia B mice with scAAV8-LP1-hFIX.

    Science.gov (United States)

    Lu, Wei; Zhou, Qingzhang; Yang, Hao; Wang, Hao; Gu, Yexing; Shen, Qi; Xue, Jinglun; Dong, Xiaoyan; Chen, Jinzhong

    2016-06-01

    Hemophilia B is a hemorrhagic disease caused by the deficiency of clotting factor IX (FIX). Gene therapy might be the ultimate strategy for the disease. However, two main problems that should be solved in gene therapy for hemophilia B are immunity and safety. Self-complementary adeno-associated virus serotype 8 (scAAV8), a non-human primate AAV featuring low immunogenicity and high transfection efficiency in liver cells, might be a potential vector for hemophilia B gene therapy. A strong liver-specific promoter-1 (LP1) was inserted and mutant human FIX Arg338Ala was introduced into plasmid scAAV8-LP1 to develop an optimized AAV8 vector that expresses human clotting factor FIX (hFIX). The efficiency of scAAV8-LP1-hFIX administered through normal systemic injection or hydrodynamic injection was compared. A high expression was achieved using hydrodynamic injection, and the peak hFIX expression levels in the 5 × 10(11) and 1 × 10(11) virus genome (vg) cohorts were 31.94% and 25.02% of normal level, respectively, at 60 days post-injection. From the perspective of long-term (200 days) expression, both injection methods presented promising results with the concentration value maintained above 4% of normal plasma. The results were further verified by enzyme-linked immunosorbent assay and activated partial thromboplastin time. Our study provides a potential gene therapy method for hemophilia B.

  19. Browse Author Index

    African Journals Online (AJOL)

    Items 101 - 150 of 167 ... KOUAME, C. Kouame, CN · Kouame, CN · Kouame, D · Kouame, D · Kouame, GK · KOUAME, L.P · Kouame, LP · Kouame, MLO · Kouame, NF · Kouamelan, EP · KOUAO, J.B. · Kouassi, AB · Kouassi, AF · Kouassi, AM · Kouassi, CK · Kouassi, F.A · Kouassi, F.W · Kouassi, FY · Kouassi, HK · Kouassi, HR

  20. 77 FR 21587 - Bayer Cropscience, LP, Including On-Site Leased Workers From Jacobs PSG, Middough Associates, Inc...

    Science.gov (United States)

    2012-04-10

    ... Employment and Training Administration Bayer Cropscience, LP, Including On-Site Leased Workers From Jacobs PSG, Middough Associates, Inc., Adecco, CDI Engineering Solutions, Becht Engineering, Engineering... Engineering Solutions, Becht Engineering, Engineering Support Systems, Manufacturing Management Services, US...

  1. Remarks on the Phragmen-Lindelof theorem for Lp-viscosity solutions of fully nonlinear PDEs with unbounded ingredients

    Directory of Open Access Journals (Sweden)

    Kazushige Nakagawa

    2009-11-01

    Full Text Available The Phragmen-Lindelof theorem for Lp-viscosity solutions of fully nonlinear second order elliptic partial differential equations with unbounded coefficients and inhomogeneous terms is established.

  2. Evaluation of the Interaction between the Poincianella pyramidalis (Tul. LP Queiroz Extract and Antimicrobials Using Biological and Analytical Models.

    Directory of Open Access Journals (Sweden)

    Thiago P Chaves

    Full Text Available Poincianella pyramidalis (Tul. LP Queiroz (Fabaceae is an endemic tree of northeastern Brazil, occurring mainly in the Caatinga. Its medicinal use is widespread and is an important therapeutic option against diarrhea, dysentery, and respiratory and urinary infections, among other diseases. In this study we determined the chemical marker and evaluated the interaction between P. pyramidalis extract and a commercial antimicrobial through the use of biological and analytical models. To obtain the extract, an ethanol-water mixture (50:50 v/v was used as solvent. It was nebulized in a spray dryer using colloidal silicon dioxide as a drying adjuvant. The extract (ENPp was subjected to HPLC analysis to verify the presence of certain secondary metabolites. The Minimum Inhibitory Concentration (MIC of the extract against Gram-negative bacteria was determined by broth microdilution and the MIC of synthetic antimicrobial drugs in the presence and absence of the extract. The antioxidant activity of ENPp was evaluated by the DPPH method. The compatibility between the antimicrobial and the extract was evaluated by thermal analysis (TG/DTA. The acute toxicity of the extract was evaluated in vivo in rodents. The results indicate significant additive action of the extract on synthetic antibiotics, considerable antioxidant activity and absence of toxicity. This extract shows high potential for the development of formulations for antimicrobial therapy when used with a vegetable-active ingredient.

  3. 34 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Science.gov (United States)

    2010-07-01

    ...]; 106.41 Adjustment period, [78]; 106.41(d) Contact sport defined, 106.41(d) Equal opportunity, [76, 77... Offerings Adjustment period, [55]; 106.34(a) (i) General, [7, 43]; 106.34 Music classes, [43]; 106.34(f...

  4. 45 CFR Subject Index to Title Ix... - Subject Index to Title IX Preamble and Regulation 1

    Science.gov (United States)

    2010-10-01

    ... obligation, 86.4(b) Form, 86.4(c) Athletics, ; 86.41 Adjustment period, ; 86.41(d) Contact sport defined, 86...) Course Offerings Adjustment period, ; 86.34(a) (i) General, ; 86.34 Music classes, ; 86.34(f) Physical...

  5. Walkability Index

    Science.gov (United States)

    The Walkability Index dataset characterizes every Census 2010 block group in the U.S. based on its relative walkability. Walkability depends upon characteristics of the built environment that influence the likelihood of walking being used as a mode of travel. The Walkability Index is based on the EPA's previous data product, the Smart Location Database (SLD). Block group data from the SLD was the only input into the Walkability Index, and consisted of four variables from the SLD weighted in a formula to create the new Walkability Index. This dataset shares the SLD's block group boundary definitions from Census 2010. The methodology describing the process of creating the Walkability Index can be found in the documents located at ftp://newftp.epa.gov/EPADataCommons/OP/WalkabilityIndex.zip. You can also learn more about the Smart Location Database at https://edg.epa.gov/data/Public/OP/Smart_Location_DB_v02b.zip.

  6. Afghanistan Index

    DEFF Research Database (Denmark)

    Linnet, Poul Martin

    2007-01-01

    The Afghanistan index is a compilation of quantitative and qualitative data on the reconstruction and security effort in Afghanistan. The index aims at providing data for benchmarking of the international performance and thus provides the reader with a quick possibility to retrieve valid...... information on progress or lack of progress in the reconstruction of the post Taliban Afghanistan. The index is mainly based on information collected on the internet in order to provide quick access to the original source. The index is under development and thus new information will be added on a continuous...

  7. Dietary inflammatory index and telomere length in subjects with a high cardiovascular disease risk from the PREDIMED-NAVARRA study: cross-sectional and longitudinal analyses over 5 y1

    Science.gov (United States)

    García-Calzón, Sonia; Zalba, Guillermo; Ruiz-Canela, Miguel; Shivappa, Nitin; Hébert, James R; Martínez, J Alfredo; Fitó, Montserrat; Gómez-Gracia, Enrique; Martínez-González, Miguel A; Marti, Amelia

    2015-01-01

    Background: Dietary factors can affect telomere length (TL), a biomarker of aging, through oxidation and inflammation-related mechanisms. A Dietary Inflammatory Index (DII) could help to understand the effect of the inflammatory potential of the diet on telomere shortening. Objective: This study aimed to determine the association of the DII with TL and to examine whether diet-associated inflammation could modify the telomere attrition rate after a 5-y follow-up of a Mediterranean dietary intervention. Design: This was a prospective study of 520 participants at high cardiovascular disease risk (mean ± SD age: 67.0 ± 6.0 y, 45% males) from the PREDIMED-NAVARRA (PREvención con DIeta MEDiterránea-NAVARRA) trial. Leukocyte TL was measured by quantitative real-time polymerase chain reaction at baseline and after 5 y of follow-up. The DII was calculated from self-reported data by using a validated 137-item food-frequency questionnaire. Results: Longer telomeres at baseline were found in participants who had a more anti-inflammatory diet (lowest DII score) (P-trend = 0.012). Longitudinal analyses further showed that a greater anti-inflammatory potential of the diet (i.e., a decrease in the DII) could significantly slow down the rate of telomere shortening. Moreover, the multivariable-adjusted OR for short telomeres (z score ≤20th percentile) was 1.80 (95% CI: 1.03, 3.17) in a comparison between the highest (proinflammatory) and the lowest (anti-inflammatory) DII tertiles. Similarly, a greater DII (greatest proinflammatory values) after a 5-y follow-up was associated with almost a 2-fold higher risk of accelerated telomere attrition compared with the highest decrease in DII (greatest anti-inflammatory values) during this period (P-trend = 0.025). Conclusions: This study showed both cross-sectional and longitudinal associations between the inflammatory potential of the diet and telomere shortening in subjects with a high cardiovascular disease risk. Our findings are

  8. Deteksi Kanker Kulit Melanoma dengan Linear Discriminant Analysis-Fuzzy k-Nearest Neigbhour Lp-Norm

    Directory of Open Access Journals (Sweden)

    Mustika Mentari

    2016-02-01

    Full Text Available Abstrak Seiring perkembangan teknologi dilakukan otomatisasi deteksi kanker kulit melalui citra dermoscopy. Pengambilan informasi fitur citra dermoscopy terganggu dengan outlier dan overfitting, karena faktor jenis kulit, penyebaran kanker yang tidak merata atau kesalahan sampling. Penelitian ini mengusulkan deteksi kanker kulit melanoma dengan mengintegrasikan metode fuzzy K-Nearest Neighbour (FuzzykNN, Lp-norm dan Linear Discriminant Analysis (LDA untuk mengurangi outlier dan overfitting. Masukan berupa citra warna RGB yang dinormalisasi menjadi RGBr. Reduksi dimensi dengan LDA menghasilkan fitur dengan nilai eigen paling menonjol. LDA pada penelitian ini menghasilkan dua fitur paling menonjol dari 141 jenis fitur, yaitu wilayah tumor dan minimum wilayah tumor channel R. Kemudian dilakukan klasifikasi FuzzykNN dan metode pengukur jarak Lp-norm. Penggunaan metode LDA dan Lp-norm dalam proses klasifikasi ini mengatasi terjadinya overfitting. Akurasi yang dihasilkan metode LDA-fuzzykNN Lp Norm, yaitu 72% saat masing-masing nilai p dan k = 25. Metode gabungan ini terbukti cukup baik dari pada metode yang dijalankan terpisah. Kata kunci: melanoma, fuzzy, KNN, Lp-norm, LDA. Abstract As the advancement of technology skin cancer detection need to be automated with the use of dermoscopy image. Outlier and overfitting are the problem in feature extraction of dermoscopy image, this can be caused by skin type, uneven cancer distribution or sampling error. This study proposed melanoma skin cancer detection by fuzzy K-Nearest Neighbour (FuzzykNN with Lp-norm integrated with Linear Discriminant Analysis (LDA to reduce the problem of outlier and overfitting. Input used in this study are images with RGB channel, then it adapted to RGBr. Dimensional reduction with LDA result in features with highest eigen value. LDA in this research select 2 discriminant, they are tumor area and minimum tumor area in R channel. This features then classified by fuzzykNN with Lp

  9. Comparison of Lipoprotein-Associated Phospholipase A2 and High Sensitive C-Reactive Protein as Determinants of Metabolic Syndrome in Subjects without Coronary Heart Disease: In Search of the Best Predictor

    Directory of Open Access Journals (Sweden)

    Mónica Acevedo

    2015-01-01

    Full Text Available High sensitivity C-reactive protein (hsCRP is a marker of metabolic syndrome (MS and cardiovascular (CV disease. Lipoprotein-associated phospholipase A2 (Lp-PLA2 also predicts CV disease. There are no reports comparing these markers as predictors of MS. Methods. Cross-sectional study comparing Lp-PLA2 and hsCRP as predictors of MS in asymptomatic subjects was carried out; 152 subjects without known atherosclerosis participated. Data were collected on demographics, cardiovascular risk factors, anthropometric and biochemical measurements, and hsCRP and Lp-PLA2 activity levels. A logistic regression analysis was performed with each biomarker and receiver operating characteristic (ROC curves were constructed for MS. Results. Mean age was 46 ± 11 years, and 38% of the subjects had MS. Mean Lp-PLA2 activity was 185 ± 48 nmol/mL/min, and mean hsCRP was 2.1 ± 2.2 mg/L. Subjects with MS had significantly higher levels of Lp-PLA2 (P=0.03 and hsCRP (P<0.0001 than those without MS. ROC curves showed that both markers predicted MS. Conclusion. Lp-PLA2 and hsCRP are elevated in subjects with MS. Both biomarkers were independent and significant predictors for MS, emphasizing the role of inflammation in MS. Further research is necessary to determine if inflammation predicts a higher risk for CV events in MS subjects.

  10. AP Index

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Planetary Amplitude index - Bartels 1951. The a-index ranges from 0 to 400 and represents a K-value converted to a linear scale in gammas (nanoTeslas)--a scale that...

  11. Expanding subjectivities

    DEFF Research Database (Denmark)

    Lundgaard Andersen, Linda; Soldz, Stephen

    2012-01-01

    A major theme in recent psychoanalytic thinking concerns the use of therapist subjectivity, especially “countertransference,” in understanding patients. This thinking converges with and expands developments in qualitative research regarding the use of researcher subjectivity as a tool to understa...

  12. Indexes to Volume 78

    Indian Academy of Sciences (India)

    Subject Index. 971. Magnetic response of split-ring resonator metamaterials: From effective medium dispersion to photonic band gaps. Sangeeta Chakrabarti and S Anantha Ramakrishna. 483–492. Determination of the optimal parameters for the fabrication of ZnO thin films prepared by spray pyrolysis method. M Ardyanian ...

  13. Indexes to Volume 79

    Indian Academy of Sciences (India)

    Subject Index. Tau reconstruction, energy calibration and identification at ATLAS. Michel Trottier-McDonald. 1337–1340. Search for a Higgs boson decaying into two photons in the CMS detector. Roberta Volpe. 1341–1344. Open flavour charmed mesons in a quantum chromodynamics potential model. Krishna Kingkar ...

  14. Lq -Lp optimization for multigrid fluorescence tomography of small animals using simplified spherical harmonics

    Science.gov (United States)

    Edjlali, Ehsan; Bérubé-Lauzière, Yves

    2018-01-01

    We present the first Lq -Lp optimization scheme for fluorescence tomographic imaging. This is then applied to small animal imaging. Fluorescence tomography is an ill-posed, and in full generality, a nonlinear problem that seeks to image the 3D concentration distribution of a fluorescent agent inside a biological tissue. Standard candidates for regularization to deal with the ill-posedness of the image reconstruction problem include L1 and L2 regularization. In this work, a general Lq -Lp regularization framework (Lq discrepancy function - Lp regularization term) is introduced for fluorescence tomographic imaging. A method to calculate the gradient for this general framework is developed which allows evaluating the performance of different cost functions/regularization schemes in solving the fluorescence tomographic problem. The simplified spherical harmonics approximation is used to accurately model light propagation inside the tissue. Furthermore, a multigrid mesh is utilized to decrease the dimension of the inverse problem and reduce the computational cost of the solution. The inverse problem is solved iteratively using an lm-BFGS quasi-Newton optimization method. The simulations are performed under different scenarios of noisy measurements. These are carried out on the Digimouse numerical mouse model with the kidney being the target organ. The evaluation of the reconstructed images is performed both qualitatively and quantitatively using several metrics including QR, RMSE, CNR, and TVE under rigorous conditions. The best reconstruction results under different scenarios are obtained with an L1.5 -L1 scheme with premature termination of the optimization process. This is in contrast to approaches commonly found in the literature relying on L2 -L2 schemes.

  15. The great contribution: Index Medicus, Index-Catalogue, and IndexCat.

    Science.gov (United States)

    Greenberg, Stephen J; Gallagher, Patricia E

    2009-04-01

    The systematic indexing of medical literature by the Library of the Surgeon-General's Office (now the National Library of Medicine) has been called "America's greatest contribution to medical knowledge." In the 1870s, the library launched two indexes: the Index Medicus and the Index-Catalogue of the Library of the Surgeon-General's Office. Index Medicus is better remembered today as the forerunner of MEDLINE, but Index Medicus began as the junior partner of what the library saw as its major publication, the Index-Catalogue. However, the Index-Catalogue had been largely overlooked by many medical librarians until 2004, when the National Library of Medicine released IndexCat, the online version of Index-Catalogue. Access to this huge amount of material raised new questions: What was the coverage of the Index-Catalogue? How did it compare and overlap with the Index Medicus? Over 1,000 randomly generated Index Medicus citations were cross-referenced in IndexCat. Inclusion, form, content, authority control, and subject headings were evaluated, revealing that the relationship between the two publications was neither simple nor static through time. In addition, the authors found interesting anomalies that shed light on how medical literature was selected and indexed in "America's greatest contribution to medical knowledge."

  16. Indexing from thesauri to the semantic web

    CERN Document Server

    de Keyser, Piet

    2012-01-01

    Indexing consists of both novel and more traditional techniques. Cutting-edge indexing techniques, such as automatic indexing, ontologies, and topic maps, were developed independently of older techniques such as thesauri, but it is now recognized that these older methods also hold expertise. Indexing describes various traditional and novel indexing techniques, giving information professionals and students of library and information sciences a broad and comprehensible introduction to indexing. This title consists of twelve chapters: an Introduction to subject readings and theasauri; Automatic i

  17. Laser polarimeter LP101M and its applications in liquid cromatography

    Science.gov (United States)

    Fajer, V.; Rodriguez, C.; Gonzalez, R.; Cossio, G.; Martinez, M.; Bravo, O.

    1996-02-01

    A high sensitivity laser polarimeter LP101M employing a He-Ne laser has been designed and constructed as a detector for liquid chromatography achieving a sensitivity better than 0.001 degree. The operation principle and technical characteristics of this instrument are described. A liquid gel chromatography column system suitable for sugar cane juice analysis was also designed and calibrated. It separated and analyzed the medium molecular weight carbohydrates and demonstrated the strong influence of these substances in the conventional polarimetric determinations.

  18. Nonlinear optics in the LP(02) higher-order mode of a fiber.

    Science.gov (United States)

    Chen, Y; Chen, Z; Wadsworth, W J; Birks, T A

    2013-07-29

    The distinct disperion properties of higher-order modes in optical fibers permit the nonlinear generation of radiation deeper into the ultraviolet than is possible with the fundamental mode. This is exploited using adiabatic, broadband mode convertors to couple light efficiently from an input fundamental mode and also to return the generated light to an output fundamental mode over a broad spectral range. For example, we generate visible and UV supercontinuum light in the LP(02) mode of a photonic crystal fiber from sub-ns pulses with a wavelength of 532 nm.

  19. Fault-Tolerant Facility Location: A Randomized Dependent LP-Rounding Algorithm

    Science.gov (United States)

    Byrka, Jaroslaw; Srinivasan, Aravind; Swamy, Chaitanya

    We give a new randomized LP-rounding 1.725-approximation algorithm for the metric Fault-Tolerant Uncapacitated Facility Location problem. This improves on the previously best known 2.076-approximation algorithm of Swamy & Shmoys. To the best of our knowledge, our work provides the first application of a dependent-rounding technique in the domain of facility location. The analysis of our algorithm benefits from, and extends, methods developed for Uncapacitated Facility Location; it also helps uncover new properties of the dependent-rounding approach.

  20. Review of Cohesion in Indexing

    Directory of Open Access Journals (Sweden)

    Hasan Ashrafi Rizi

    2007-07-01

    Full Text Available Indexers often disagree on judging terms that best reflect the content of a document. Difference of opinion highlights one of the characteristics of indexing which is indexing cohesion. Also known as consistency, little study of the subject matter has been undertaken in the past few years. However, its importance has been recently acknowledged in effective information retrieval and expansion of access points to the document content. The present paper investigates cohesion in indexing. In addition of presenting the definitions offered by experts, it takes note of the factors influencing indexing cohesion. Methods for measuring cohesion are offered.

  1. Comparison of a lightweight polypropylene mesh (Optilene® LP) and a large-pore knitted PTFE mesh (GORE® INFINIT® mesh)--Biocompatibility in a standardized endoscopic extraperitoneal hernia model.

    Science.gov (United States)

    Jacob, Dietmar A; Schug-Pass, Christine; Sommerer, Florian; Tannapfel, Andrea; Lippert, Hans; Köckerling, Ferdinand

    2012-02-01

    The use of a mesh with good biocompatibility properties is of decisive importance for the avoidance of recurrences and chronic pain in endoscopic hernia repair surgery. As we know from numerous experiments and clinical experience, large-pore, lightweight polypropylene meshes possess the best biocompatibility. However, large-pore meshes of different polymers may be used as well and might be an alternative solution. Utilizing a totally extraperitoneal technique in an established animal model, 20 domestic pigs were implanted with either a lightweight large-pore polypropylene (PP) mesh (Optilene® LP) or a medium-weight large-pore knitted polytetrafluorethylene (PTFE) mesh (GORE® INFINIT® mesh). After 94 days, the pigs were sacrificed and postmortem diagnostic laparoscopy was performed, followed by explantation of the specimens for macroscopic, histological and immunohistochemical evaluation. The mean mesh shrinkage rate was 14.2% for Optilene® LP vs. 24.7% for INFINIT® mesh (p = 0.017). The partial volume of the inflammatory cells was 11.2% for Optilene® LP vs. 13.9% for INFINIT (n.s.). CD68 was significantly higher for INFINIT (11.8% vs. 5.6%, p = 0.007). The markers of cell turnover, namely Ki67 and the apoptotic index, were comparable at 6.4% vs. 12.4% (n.s.) and 1.6% vs. 2.0% (n.s.). In the extracellular matrix, TGF-β was 35.4% for Optilene® LP and 31.0% for INFINIT® (n.s.). Collagen I (pos/300 μm) deposits were 117.8 and 114.9, respectively. In our experimental examinations, Optilene® LP and INFINIT® showed a comparable biocompatibility in terms of chronic inflammatory reaction; however, the shrinkage rate was significantly higher for INFINIT® after 3 months. The higher shrinkage rate of INFINIT® should be taken into account when choosing the mesh size for an adequate hernia overlap.

  2. X-Ray-based Kinematic Analysis of Cervical Spine According to Prosthesis Designs: Analysis of the Mobi C, Bryan, PCM, and Prestige LP.

    Science.gov (United States)

    Park, Sung B; Kim, Ki J; Jin, Yong J; Kim, Hyun J; Jahng, Tae-A; Chung, Chun K

    2015-06-01

    A retrospective study. To identify significant kinematic changes in the cervical spine after cervical artificial disk replacement (ADR) using prostheses with diverse designs. Various types of artificial disks are used for cervical ADR. However, few clinical studies with a follow-up of 2 or more years have reported on the change in the curvatures and range of motion (ROM) of the cervical spine after cervical ADR in relation to different designs. The cohort comprised 58 patients who underwent single-level cervical ADR for radiculopathy. The patients were divided into 4 groups according to the device they received: Mobi-C, Bryan, PCM, and Prestige LP. The radiographs of the cervical spine were obtained preoperatively and at 12, 24, and 36 months after surgery. Several kinematic parameters, including lordotic angles and ROM of the cervical spine, index level, and superior and inferior adjacent disk levels, were assessed preoperatively and at predefined follow-up time points. Cervical sagittal lordosis in patients who received Bryan and PCM prostheses increased at the last follow-up period. The 4 patient groups showed a trend toward an increase of lordosis in the superior adjacent segment with time. The patients who received the Bryan device lost their preoperative lordotic angle at the inferior adjacent level. The ROM of the cervical spine in patients who received Bryan and PCM prostheses increased at the last follow-up compared with preoperative values. The incidence of adjacent segment degeneration in the Mobi-C, Bryan, Prestige LP, and PCM groups were 14.2%, 25%, 9.0%, and 7.6%, respectively. These results suggest preservation of sagittal ROM and increased superior adjacent segment kinematics, regardless of prosthesis design. Devices with an unconstrained design may not be beneficial to adjacent segment kinematics compared with semiconstrained prostheses.

  3. Walkability Index

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Walkability Index dataset characterizes every Census 2010 block group in the U.S. based on its relative walkability. Walkability depends upon characteristics of...

  4. Diversity Index

    Data.gov (United States)

    Town of Chapel Hill, North Carolina — This map service summarizes racial and ethnic diversity in the United States in 2012.The Diversity Index shows the likelihood that two persons chosen at random from...

  5. Writing and the 'Subject'

    DEFF Research Database (Denmark)

    Greve, Charlotte

    /reading subject) manifests itself in the material mark on the page. The study shows how this indexical reference to a ‘subject’ is manipulated and used as a mask through which a writer/painter can perform a certain ‘subject’. Through analyses of the various levels on which the ‘subject’ is represented...... in the early as well as the contemporary avant-garde, it becomes clear that the ‘subject’ is an unstable category that can be exposed to manipulation and play. Handwriting is performing as a signature (as an index), but is at the same time similar to the signature of a subject (an icon) and a verbal construct...

  6. Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A2 (Lp-PLA2 : a review

    Directory of Open Access Journals (Sweden)

    Damasceno Nágila RT

    2011-09-01

    Full Text Available Abstract The association of cardiovascular events with Lp-PLA2 has been studied continuously today. The enzyme has been strongly associated with several cardiovascular risk markers and events. Its discovery was directly related to the hydrolysis of the platelet-activating factor and oxidized phospholipids, which are considered protective functions. However, the hydrolysis of bioactive lipids generates lysophospholipids, compounds that have a pro-inflammatory function. Therefore, the evaluation of the distribution of Lp-PLA2 in the lipid fractions emphasized the dual role of the enzyme in the inflammatory process, since the HDL-Lp-PLA2 enzyme contributes to the reduction of atherosclerosis, while LDL-Lp-PLA2 stimulates this process. Recently, it has been verified that diet components and drugs can influence the enzyme activity and concentration. Thus, the effects of these treatments on Lp-PLA2 may represent a new kind of prevention of cardiovascular disease. Therefore, the association of the enzyme with the traditional assessment of cardiovascular risk may help to predict more accurately these diseases.

  7. The Lp Lp Lp-curvature images of convex bodies and Lp Lp Lp ...

    Indian Academy of Sciences (India)

    Associated with the -curvature image defined by Lutwak, some inequalities for extended mixed -affine surface areas of convex bodies and the support functions of -projection bodies are established. As a natural extension of a result due to Lutwak, an -type affine isoperimetric inequality, whose special cases are ...

  8. Effect of nicotine on melanogenesis and antioxidant status in HEMn-LP melanocytes

    Energy Technology Data Exchange (ETDEWEB)

    Delijewski, Marcin; Beberok, Artur; Otręba, Michał; Wrześniok, Dorota; Rok, Jakub; Buszman, Ewa, E-mail: ebuszman@sum.edu.pl

    2014-10-15

    Nicotine is a natural ingredient of tobacco plants and is responsible for the addictive properties of tobacco. Nowadays nicotine is also commonly used as a form of smoking cessation therapy. It is suggested that nicotine may be accumulated in human tissues containing melanin. This may in turn affect biochemical processes in human cells producing melanin. The aim of this study was to examine the effect of nicotine on melanogenesis and antioxidant status in cultured normal human melanocytes HEMn-LP. Nicotine induced concentration-dependent loss in melanocytes viability. The value of EC{sub 50} was determined to be 7.43 mM. Nicotine inhibited a melanization process in human light pigmented melanocytes and caused alterations of antioxidant defense system. Significant changes in cellular antioxidant enzymes: superoxide dismutase and catalase activities and in hydrogen peroxide content were stated. The obtained results may explain a potential influence of nicotine on biochemical processes in melanocytes in vivo during long term exposition to nicotine. - Graphical abstract: Nicotine inhibits melanogenesis and induces oxidative stress in HEMn-LP melanocytes. - Highlights: • Nicotine induces concentration-dependent loss in melanocytes viability. • Nicotine in non-cytotoxic concentrations inhibits melanogenesis. • Nicotine in higher concentrations induces oxidative stress.

  9. Observerless Scheme for Sensorless Speed Control of PMSM Using Direct Torque Control Method With LP Filter

    Directory of Open Access Journals (Sweden)

    BEKIROGLU, N.

    2010-08-01

    Full Text Available In this study, direct torque control (DTC of a permanent magnet synchronous motor is realized with a sensorless speed control technique without using an observer. Space vector pulse width modulation (SVPWM technique is applied in order to determine the switching sequence of the voltage source inverter. Torque and flux, the main variables of the DTC, are estimated by using the mathematical model of the motor. Estimated torque and flux values are compared with their references in every control cycle. Then, according to the torque and flux demand, the voltage vector is constituted. In the proposed control scheme, speed is estimated by using flux calculations and a PI controller is used to process the torque and flux errors. Furthermore, a low-pass (LP filter is implemented within the proposed system for voltage and current harmonics suppression. The results proved that proposed scheme for the DTC provides the speed control under various torque demands without employing a sensor. The proposed system performs very well for a sensorless operation and effectively eliminates the harmonics due to the LP filter.

  10. LP Norm SAR Tomography by Iteratively Rewighted Least Square: First Results on Hong Kong

    Science.gov (United States)

    Mancon, Simone; Tebaldini, Stefano; Monti Guarnieri, Andre

    2014-11-01

    Synthetic aperture radar tomography (TomoSAR) is the natural extension to 3-D of conventional 2-D Synthetic Aperture Radar (SAR) imaging. In this work, we focus on urban scenarios where targets of interest are point-like and radiometrically strong, i.e. the reflectivity profile in elevation is sparse. Accordingly, the method for TomoSAR imaging suggested in this work is based on Compressive Sensing (CS) theory. CS problems are typically solved by looking for the minimal solution in some Lp norm, where 0≤ p ≤ 1. The solution that minimizes an arbitrary Lp norm can be obtained using the Iteratively Reweighted Least Square (IRLS) algorithm. Based on an experimental comparison among different choices for p, the conclusion drawn is that the usual choice p = 1 is the best trade-off between resolution and robustness to noise. Results from real data will be discussed by reporting a TomoSAR reconstruction of an area in Hong Kong (China), acquired by COSMO-SkyMed.

  11. Immune-enhancing effect of nanometricLactobacillus plantarumnF1 (nLp-nF1) in a mouse model of cyclophosphamide-induced immunosuppression.

    Science.gov (United States)

    Choi, Dae-Woon; Jung, Sun Young; Kang, Jisu; Nam, Young-Do; Lim, Seong-Il; Kim, Ki Tae; Shin, Hee Soon

    2017-11-15

    Nanometric Lactobacillus plantarum nF1 (nLp-nF1) is a biogenics consisting of dead L. plantarum pre-treated with heat and a nanodispersion process. In this study, we investigated the immune-enhancing effects of nLp-nF1 in vivo and in vitro . To evaluate the immunostimulatory effects of nLp-nF1, mice immunosuppressed by cyclophosphamide (CPP) treatment were administered with nLp-nF1. As expected, CPP restricted the immune response of mice, whereas oral administration of nLp-nF1 significantly increased total IgG in serum, and cytokine production [interleukin-12 (IL-12) and tumor necrosis factor alpha (TNF-α)] in bone marrow cells. Furthermore, nLp-nF1 enhanced the production of splenic cytokines such as IL-12, TNF-α, and interferon gamma (IFN-γ). In vitro , nLp-nF1 stimulated the immune response by enhancing the production of cytokines such as IL-12, TNF-α, and IFN-γ. Moreover, nLp-nF1 given a food additive enhanced the immune responses when combined with various food materials on in vitro . These results suggest that nLp-nF1 could be used to strengthen the immune system and recover normal immunity in people with a weaker immune system, such as children, the elderly, and patients.

  12. Nuclear Energy Standards. KWIC index

    Energy Technology Data Exchange (ETDEWEB)

    1984-01-01

    The KWIC Index is an alphabetical listing that provides rapid identification of NE standards based upon the specific subject areas. This index facilitates identification of a NE standard by major or key words located in the center of the alphabetical index listing. Alphanumerical designations for specific NE standards are shown in the right-hand column. Standards referenced in this listing include those that are active, inactive, or discontinued.

  13. Virginia ESI: INDEX (Index Polygons)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains vector polygons representing the boundaries of all hardcopy cartographic products produced as part of the Environmental Sensitivity Index...

  14. Visualisering av farmakologiska substanser i levervävnad med hjälp av masspketrometrisk bildtagning

    OpenAIRE

    Mäkinen, Matias

    2017-01-01

    Målet för detta forskningsprojekt var att utveckla en metod med vars hjälp det är möjligt att detektera farmakologiska substanser i levervävnad med hjälp av masspektrometrisk bildtagning, så kallad MALDI-MSI. I litteraturen finns beskrivet tillämpningar av MALDI-MSI med vars hjälp det detekterats till exempel lipider i vävnader eller såsom i denna studie farmkologiska substanser. Arbetet bestod av två delmoment. I den första delen isolerades hepatocyter ur råttlever genom att perfusera k...

  15. Insertion of apoLp-III into a lipid monolayer is more favorable for saturated, more ordered, acyl-chains

    Energy Technology Data Exchange (ETDEWEB)

    Rathnayake, Sewwandi S. [Kent State Univ., Kent, OH (United States); Mirheydari, Mona [Kent State Univ., Kent, OH (United States); Schulte, Adam [Kent State Univ., Kent, OH (United States); Gillahan, James E. [Kent State Univ., Kent, OH (United States); Gentit, Taylor [Kent State Univ., Kent, OH (United States); Phillips, Ashley N. [Kent State Univ., Kent, OH (United States); Okonkwo, Rose K. [Kent State Univ., Kent, OH (United States); Burger, Koert N.J. [Utrecht Univ. (Netherlands); Mann, Elizabeth K. [Kent State Univ., Kent, OH (United States); Vaknin, David [Ames Lab., Ames, IA (United States); Bu, Wei [Ames Lab., Ames, IA (United States); Agra-Kooijman, Dena Mae [Kent State Univ., Kent, OH (United States); Kooijman, Edgar E. [Kent State Univ., Kent, OH (United States)

    2013-10-04

    Neutral lipid transport in mammals is complicated involving many types of apolipoprotein. The exchangeable apolipoproteins mediate the transfer of hydrophobic lipids between tissues and particles, and bind to cell surface receptors. Amphipathic a-helices form a common structural motif that facilitates their lipid binding and exchangeability. ApoLp-III, the only exchangeable apolipoprotein found in insects, is a model amphipathic a:helix bundle protein and its three dimensional structure and function mimics that of the mammalian proteins apoE and apoAI. Even the intracellular exchangeable lipid droplet protein TIP47/perilipin 3 contains an a-helix bundle domain with high structural similarity to that of apoE and apoLp-III. Here, we investigated the interaction of apoLp-III from Locusta migratoria with lipid monolayers. Consistent with earlier work we find that insertion of apoLp-III into fluid lipid monolayers is highest for diacylglycerol. We observe a preference for saturated and more highly ordered lipids, suggesting a new mode of interaction for amphipathic a-helix bundles. X-ray reflectivity shows that apoLp-III unfolds at a hydrophobic interface and flexible loops connecting the amphipathic cc-helices stay in solution. X-ray diffraction indicates that apoLp-III insertion into diacylglycerol monolayers induces additional ordering of saturated acyl-chains. These results thus shed important new insight into the protein-lipid interactions of a model exchangeable apolipoprotein with significant implications for its mammalian counterparts. (C) 2013 Elsevier B.V. All rights reserved.

  16. Influence of fruit drinks with or without lactobacillus Lp299v on the gastrointestinal uptake of paracetamol in man

    DEFF Research Database (Denmark)

    Akerman, Ulrika; Edvinsson, Lars

    2009-01-01

    (a 95% confidence interval of 57,161). The corresponding 30 minutes values of paracetamol levels in the presence of rosehip with or without Lp299v were 0 mumol/l (95% confidence intervals contain only zero for both rosehip treatments). There were significant differences in AUC, maximal paracetamol...... = 0.003); there were no significant difference between rosehip drink with or without Lp299v (p > 0.3). CONCLUSION: We have demonstrated an interaction between the uptake of paracetamol and the solvent in rosehip drink/Provia which mainly consists of long chain carbohydrates. This may in the clinic...

  17. Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a levels in African Americans.

    Directory of Open Access Journals (Sweden)

    Rahul C Deo

    2011-01-01

    Full Text Available Lipoprotein(a (Lp(a is an important causal cardiovascular risk factor, with serum Lp(a levels predicting atherosclerotic heart disease and genetic determinants of Lp(a levels showing association with myocardial infarction. Lp(a levels vary widely between populations, with African-derived populations having nearly 2-fold higher Lp(a levels than European Americans. We investigated the genetic basis of this difference in 4464 African Americans from the Jackson Heart Study (JHS using a panel of up to 1447 ancestry informative markers, allowing us to accurately estimate the African ancestry proportion of each individual at each position in the genome. In an unbiased genome-wide admixture scan for frequency-differentiated genetic determinants of Lp(a level, we found a convincing peak (LOD = 13.6 at 6q25.3, which spans the LPA locus. Dense fine-mapping of the LPA locus identified a number of strongly associated, common biallelic SNPs, a subset of which can account for up to 7% of the variation in Lp(a level, as well as >70% of the African-European population differences in Lp(a level. We replicated the association of the most strongly associated SNP, rs9457951 (p = 6 × 10(-22, 27% change in Lp(a per allele, ∼5% of Lp(a variance explained in JHS, in 1,726 African Americans from the Dallas Heart Study and found an even stronger association after adjustment for the kringle(IV repeat copy number. Despite the strong association with Lp(a levels, we find no association of any LPA SNP with incident coronary heart disease in 3,225 African Americans from the Atherosclerosis Risk in Communities Study.

  18. Coupled-Flow Simulation of HP-LP Turbines Has Resulted in Significant Fuel Savings

    Science.gov (United States)

    Veres, Joseph P.

    2001-01-01

    Our objective was to create a high-fidelity Navier-Stokes computer simulation of the flow through the turbines of a modern high-bypass-ratio turbofan engine. The simulation would have to capture the aerodynamic interactions between closely coupled high- and low-pressure turbines. A computer simulation of the flow in the GE90 turbofan engine's high-pressure (HP) and low-pressure (LP) turbines was created at GE Aircraft Engines under contract with the NASA Glenn Research Center. The three-dimensional steady-state computer simulation was performed using Glenn's average-passage approach named APNASA. The areas upstream and downstream of each blade row mutually interact with each other during engine operation. The embedded blade row operating conditions are modeled since the average passage equations in APNASA actively include the effects of the adjacent blade rows. The turbine airfoils, platforms, and casing are actively cooled by compressor bleed air. Hot gas leaks around the tips of rotors through labyrinth seals. The flow exiting the high work HP turbines is partially transonic and, therefore, has a strong shock system in the transition region. The simulation was done using 121 processors of a Silicon Graphics Origin 2000 (NAS 02K) cluster at the NASA Ames Research Center, with a parallel efficiency of 87 percent in 15 hr. The typical average-passage analysis mesh size per blade row was 280 by 45 by 55, or approx.700,000 grid points. The total number of blade rows was 18 for a combined HP and LP turbine system including the struts in the transition duct and exit guide vane, which contain 12.6 million grid points. Design cycle turnaround time requirements ran typically from 24 to 48 hr of wall clock time. The number of iterations for convergence was 10,000 at 8.03x10(exp -5) sec/iteration/grid point (NAS O2K). Parallel processing by up to 40 processors is required to meet the design cycle time constraints. This is the first-ever flow simulation of an HP and LP

  19. Author Index

    Indian Academy of Sciences (India)

    Astr. (2010) 31, 221–222. Author Index. Aggarwal Malini see Jain Rajmal, 155. Aghaee, A. Determination of the Mean Hi Absorption of the Intergalactic. Medium, 59. Agrawal, S. P. see Singh Ambika, 89. Biesiada Marek Could the Optical Transient SCP 06F6 be due to Micro- lensing?, 213. C¸ aliskan, S . see Küçük, ˙I., 135.

  20. INDEXING MECHANISM

    Science.gov (United States)

    Kock, L.J.

    1959-09-22

    A device is presented for loading and unloading fuel elements containing material fissionable by neutrons of thermal energy. The device comprises a combination of mechanical features Including a base, a lever pivotally attached to the base, an Indexing plate on the base parallel to the plane of lever rotation and having a plurality of apertures, the apertures being disposed In rows, each aperture having a keyway, an Index pin movably disposed to the plane of lever rotation and having a plurality of apertures, the apertures being disposed in rows, each aperture having a keyway, an index pin movably disposed on the lever normal to the plane rotation, a key on the pin, a sleeve on the lever spaced from and parallel to the index pin, a pair of pulleys and a cable disposed between them, an open collar rotatably attached to the sleeve and linked to one of the pulleys, a pin extending from the collar, and a bearing movably mounted in the sleeve and having at least two longitudinal grooves in the outside surface.

  1. AUTHOR INDEX

    Indian Academy of Sciences (India)

    user1

    AUTHOR INDEX. Abtahi Fatemeh. Completely continuous and weakly co- mpletely continuous abstract Segal algebras. 539. Afrouzi G A. Remark on an infinite semipositone prob- lem with indefinite weight and falling zeros. 145. Balasubramanian R. Density of primes in l-th power residues. 19. Banerjee Pradipto. Divisibility ...

  2. AUTHOR INDEX

    Indian Academy of Sciences (India)

    AUTHOR INDEX. Abada Asmaa see Das Debottam. 867. Abbas Gauhar. Constraints on the Kl3 form factors from analyticity and unitarity. 891. Abou El-Ela F M. Electron transport in wurtzite InN. 125. Adachi M M see Kumar Sunil ..... Trottier-McDonald Michel. Tau reconstruction, energy calibration and identification at ATLAS.

  3. Index Fossils

    Indian Academy of Sciences (India)

    Permanent link: http://www.ias.ac.in/article/fulltext/reso/011/10/0069-0077. Keywords. Index fossil; guide fossil; correlation; age determination; Dicroidium; Glossopteris. Author Affiliations. Dipanjan Ghosh1. Biological Science Department Kirnahar Shib Chandra High School Kirnahar, Birbhum 731302, West Bengal, India.

  4. Indexes to Nuclear Regulatory Commission issuances, January--June 1995. Volume 41, Index 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    Digests and indexes for issuances of the Commission (CLI), the Atomic Safety and Licensing Board Panel (LBP), the Administrative Law Judges (ALJ), the directors` Decisions (DD), and the Denials of Petitions for rulemaking (DPRM) are presented in this document. These digests and indexes are intended to serve as a guide to the issuances. The information elements are displayed in one or more of five separate formats arranged as follows: Case name index; digests and headers; legal citations index; subject index; and facility index.

  5. Indexes to Nuclear Regulatory Commission Issuances, July--December 1993. Volume 38, Index 2

    Energy Technology Data Exchange (ETDEWEB)

    1994-04-01

    Digests and indexes for issuances of the Commission (CLI), the Atomic Safety and Licensing Board Panel (LBP), the Administrative Law Judges (ALJ), the Directors` Decisions (DD), and the Denials of Petitions for Rulemaking (DPRM) are presented in this document. These digests and indexes are intended to serve as a guide to the issuances. These information elements are displayed in one or more of five separate formats arranged as follows: Case Name Index; Digests and Headers; Legal Citations Index; Subject Index, and Facility Index.

  6. Analisis Kata Tabu dan Klasifikasinya di Lirik Lagu Eminem pada Album `The Marshal Mathers LP`

    Directory of Open Access Journals (Sweden)

    Laily Nur Affini

    2017-04-01

    Full Text Available This research is dedicated for readers in the field of linguistics and has a purpose to reveal taboo words based on a certain theory and the classifications. The analysed taboo words exist in Emeninems album,The Marshall Mathers LP. A theory employed in the analysis is using Timothy Jay theory where taboo words are differentiated in seven classifications; cursing, profanity, blasphemy, obscenity, sexual harassment, vulgar language, name-calling and insult.The data was taken into two parts, primary and secondary. The primary data is the lyric itself and the secondary data is taken from books, articles and dictionary. The result of the analysis shows a revelation of the taboo words classifications, shown up in a table.

  7. 78 FR 13742 - BB&T Capital Partners Mezzanine Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the...

    Science.gov (United States)

    2013-02-28

    ... ADMINISTRATION BB&T Capital Partners Mezzanine Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that BB&T Capital Partners... Regulations (13 CFR 107.730). BB&T Capital Partners Mezzanine Fund II, L.P. proposes to provide debt financing...

  8. 77 FR 76586 - GC SBIC IV, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act...

    Science.gov (United States)

    2012-12-28

    ... Regulations (13 CFR 107.730). GC SBIC IV, L.P. provided loan financing to Massage Envy LLC, 14350 N. 87th... the Regulations because Massage Envy LLC used financing proceeds from GC SBIC IV, L.P. in part to...

  9. 77 FR 74545 - Eagle Fund III-A, L.P.; License No. 07/07-0117: Notice Seeking Exemption Under Section 312 of the...

    Science.gov (United States)

    2012-12-14

    ... ADMINISTRATION Eagle Fund III-A, L.P.; License No. 07/07-0117: Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that Eagle Fund III-A, L.P... interest, of the Small Business Administration Rules and Regulations (13 CFR part 107). Eagle Fund III- A...

  10. 77 FR 70812 - United States v. Star Atlantic Waste Holdings, L.P., Veolia Environnement S.A. and Veolia ES...

    Science.gov (United States)

    2012-11-27

    ... Antitrust Division United States v. Star Atlantic Waste Holdings, L.P., Veolia Environnement S.A. and Veolia... Environnement S.A. and Veolia ES Solid Waste, Inc., Civil Action No. 1:12-cv-01847-RWR. On November 15, 2012... Holdings, L.P. of Veolia Environnement S.A.'s U.S. subsidiary, Veolia ES Solid Waste, Inc., would violate...

  11. A Novel Low-Temperature Alkaline Lipase from Acinetobacter johnsonii LP28 Suitable for Detergent Formulation

    Directory of Open Access Journals (Sweden)

    Hai Kuan Wang

    2011-01-01

    Full Text Available A strain LP28 that produces alkaline and low-temperature lipase was isolated from the soil collected from the Bay of Bohai, PR China and identified as Acinetobacter johnsonii using 16S rDNA sequencing. The lipase was purified to homogeneity by centrifugation, followed by ammonium sulphate precipitation, dialysis, ion exchange chromatography on cellulose DE-52 and gel filtration chromatography on Sephadex G-75. The enzyme was purified about 34-fold with a final yield of 13 % and the relative molecular mass of the enzyme was determined to be 53 kDa by SDS-PAGE. The purified enzyme exhibited maximum activity at 30 °C and pH=9.0, and retained 94.53 % of its maximum activity at 20 °C. The enzyme was stable at 50 °C and retained 80.9 % of its original activity for 30 min. It was also highly stable in a pH range of 8.0–11.0. The enzyme hydrolyzed a wide range of oils and showed a high level of lipase activity in hydrolyzing tributyrin. The enzyme activity was promoted in the presence of Na+, Ca2+, K+, Mg2+ and sodium citrate. Ba2+, Mn2+, Cr3+ and Co2+ did not affect the enzyme activity, whereas the presence of Al3+, Cu2+, Fe2+, Fe3+, Zn2+ and EDTA reduced the enzyme activity. Regarding the stability of detergent process, the enzyme was highly stable in the presence of various oxidizing agents, some commercial detergents and alkaline protease, and its activity was also promoted by most of the surfactants, viz. Tween 20, Tween 80, sodium cholate, sodium taurocholate and saponin. For these characteristics, the lipase from Acinetobacter johnsonii LP28 showed good potential as an additive in laundry detergent formulation.

  12. Effects of Supportive Educational Program on Anxiety of Mothers of Children Undergoing the Lumbar Puncture (LP

    Directory of Open Access Journals (Sweden)

    Mousa Mahdizadeh

    2016-07-01

    Full Text Available Background: Lumbar Puncture test is one of the most stressful diagnostic procedures in pediatric ward that its prescription put mothers under extreme pressure. There are limited interventions in this regard. Aim: determining the impact of supportive educational program on the anxiety of mothers whose children are undergoing lumbar puncture (LP. Method: the present study is a randomized controlled clinical trial carried out in 2015. Sixty mothers of children undergoing lumbar puncture and hospitalized 3educational hospitals of Mashhad, Iran, were randomly divided to control group (n=30 and intervention group (n=30. The intervention group received supportive program during a session of 60 min. Spielberger State-Trait Anxiety Inventory (STAI was selected as the research tool. Finally, data were analyzed by Chi-square test, independent t-test using SPSS v.16 software. Results: The mean age of the mothers was 27.3±5.3 and 26.0±3.1, respectively. The mean pre-interventions maternal manifest anxiety was 51.9±6.2 and 53.4±4.3 out of 80, respectively, in the intervention and control groups. The mean post-interventions maternal manifest anxiety was 44.9±5.1 and 52.7±4.2, respectively, in the intervention and control groups. According to the results of independent t-test, significant difference was observed statistically for the mean maternal manifest anxiety between the two groups (p> 0.001. Implications for Practice: Regarding the reduction of maternal anxiety in the intervention group, which is possible because of the attention to the emotional needs of mothers, in addition to proper training; this program can be considered as an effective method to reduce maternal anxiety before the LP test.

  13. International Energy: Subject Thesaurus

    Energy Technology Data Exchange (ETDEWEB)

    Raridon, M.H. (ed.)

    1990-01-01

    The International Energy Subject Thesaurus contains the standard vocabulary to indexing terms (descriptors) developed and structured to build and maintain energy information databases. Involved in this cooperative task are (1) the technical staff of the USDOE Office of Scientific and Technical Information (OSTI) in cooperation with the member countries of the Energy Technology Data Exchange (ETDE) and (2) the International Nuclear Information System (INIS) staff representing the more than ninety countries and organizations recording and indexing information for the international nuclear information community. ETDE member countries are also members of the International Nuclear Information System (INIS). Nuclear information indexed and recorded for INIS by these ETDE member countries is also included in the ETDE Energy Data Base, and indexing terminology is therefore cooperatively standardized for use in both information systems. This structured vocabulary reflects the scope of international energy research, development, and technological programs and encompasses terminology derived not only from the basic sciences but also from the areas of energy resources, conservation, safety, environmental impact, and regulation.

  14. Characterization of learning and memory deficits in C57BL/6 mice infected with LP-BM5, a murine model of AIDS.

    Science.gov (United States)

    Iida, R; Yamada, K; Mamiya, T; Saito, K; Seishima, M; Nabeshima, T

    1999-03-01

    Mice infected with an immunosuppressive murine leukemia virus mixture, LP-BM5 show a profound immunosuppression described as murine acquired immune deficiency syndrome (AIDS). In the present study, we characterized learning and memory deficits in C57BL/6 mice infected with LP-BM5. Spontaneous alternation behavior in a Y-maze and latent learning (spatial attention) in a water-finding test, as well as spatial reference and reversal learning in a water maze test, were significantly impaired in the mice infected with LP-BM5. These deficits appeared in the absence of any motoric and visual impairment as assessed by open-field, rotarod and visual water maze tests. These results suggest that cognitive functions are impaired in the mice infected with LP-BM5. Furthermore, LP-BM5-infected mice may be useful as a model for the AIDS dementia complex.

  15. 75 FR 76037 - HAVI Logistics, North America a Subsidiary of HAVI Group, LP Including On-Site Leased Workers of...

    Science.gov (United States)

    2010-12-07

    ... Employment and Training Administration HAVI Logistics, North America a Subsidiary of HAVI Group, LP Including... Logistics, North America, Lisle, IL; Amended Certification Regarding Eligibility To Apply for Worker... Assistance on September 3, 2010, applicable to workers of HAVI Logistics, North America, a subsidiary of HAVI...

  16. 78 FR 28273 - Alpine Investors IV SBIC, LP; Notice Seeking Exemption Under Section 312 of the Small Business...

    Science.gov (United States)

    2013-05-14

    ... Investment Act, Conflicts of Interest Notice is hereby given that Alpine Investors IV SBIC, LP, 3 Embarcadero Center, Suite 2330, San Francisco, CA, a Federal Licensee under the Small Business Investment Act of 1958... percent of the stock of Great Bay Software, Inc., to fund transaction fees, and for working capital...

  17. 77 FR 24723 - AstraZeneca Pharmaceuticals LP; Withdrawal of Approval of a New Drug Application for IRESSA

    Science.gov (United States)

    2012-04-25

    ... HUMAN SERVICES Food and Drug Administration AstraZeneca Pharmaceuticals LP; Withdrawal of Approval of a New Drug Application for IRESSA AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is withdrawing approval of a new drug application (NDA) for...

  18. Optimal design for crosstalk analysis in 12-core 5-LP mode homogeneous multicore fiber for different lattice structure

    Science.gov (United States)

    Kumar, Dablu; Ranjan, Rakesh

    2018-03-01

    12-Core 5-LP mode homogeneous multicore fibers have been proposed for analysis of inter-core crosstalk and dispersion, with four different lattice structures (circular, 2-ring, square lattice, and triangular lattice) having cladding diameter of 200 μm and a fixed cladding thickness of 35 μm. The core-to-core crosstalk impact has been studied numerically with respect to bending radius, core pitch, transmission distance, wavelength, and core diameter for all 5-LP modes. In anticipation of further reduction in crosstalk levels, the trench-assisted cores have been incorporated for all respective designs. Ultra-low crosstalk (-138 dB/100 km) has been achieved through the triangular lattice arrangement, with trench depth Δ2 = -1.40% for fundamental (LP01) mode. It has been noted that the impact of mode polarization on crosstalk behavior is minor, with difference in crosstalk levels between two polarized spatial modes as ≤0.2 dB. Moreover, the optimized cladding diameter has been obtained for all 5-LP modes for a target value of crosstalk of -50 dB/100 km, with all the core arrangements. The dispersion characteristic has also been analyzed with respect to wavelength, which is nearly 2.5 ps/nm km at operating wavelength 1550 nm. The relative core multiplicity factor (RCMF) for the proposed design is obtained as 64.

  19. 75 FR 76040 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

    Science.gov (United States)

    2010-12-07

    ... Resources and Recovery, SecurAmerica, LLC, Industrial Distribution Group (IDG), LLC, ARM Automation, Inc... Employment and Training Administration Dell Products LP, Winston-Salem (WS-1) Division, Including On- Site... Solutions, South East, Omni Resources and Recovery, SecurAmerica, LLC, Industrial Distribution Group (IDG...

  20. 76 FR 21034 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

    Science.gov (United States)

    2011-04-14

    ... Employment and Training Administration Dell Products LP, Winston-Salem (WS-1) Division, Including On- Site... Solutions, South East, Omni Resources And Recovery, Securamerica, LLC, Industrial Distribution Group (IDG), LLC, Arm Automation, Inc., Seaton Corporation, Foxconn/PCE Technology, Inc. and Select Staffing, Also...

  1. 76 FR 76475 - Tregaron Opportunity Fund I, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

    Science.gov (United States)

    2011-12-07

    ... Business Investment Act, Conflicts of Interest Notice is hereby given that Tregaron Opportunity Fund I, L.P., 540 University Avenue, Suite 250, Palo Alto, CA 94301, a Federal Licensee under the Small Business... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS...

  2. 78 FR 48177 - Purdue Pharma L.P.; Withdrawal of Approval of a New Drug Application for Oxycontin

    Science.gov (United States)

    2013-08-07

    .... FDA-2013-N-0883] Purdue Pharma L.P.; Withdrawal of Approval of a New Drug Application for Oxycontin...) is withdrawing approval of a new drug application (NDA) for OXYCONTIN (oxycodone hydrochloride...: FDA approved NDA 20-553 for OXYCONTIN (oxycodone hydrochloride) Extended-Release Tablets, 10...

  3. 76 FR 54758 - Alliance Pipeline L.P.; Notice of Intent To Prepare an Environmental Assessment for the Planned...

    Science.gov (United States)

    2011-09-02

    ... the Commission's pre-filing process. A flow chart illustrating the pre-filing process is included with... Project involving construction and operation of facilities by Alliance Pipeline L.P. (Alliance) in... Commission in its decision-making process to determine whether the project is in the public convenience and...

  4. 76 FR 51966 - Texas Eastern Transmission, LP; Notice of Intent To Prepare an Environmental Assessment for the...

    Science.gov (United States)

    2011-08-19

    ... not your only public input opportunity; please refer to the Environmental Review Process flow chart in... Expansion Project involving construction and operation of facilities by Texas Eastern Transmission, LP...- making process to determine whether the project is in the public convenience and necessity. This notice...

  5. 76 FR 63278 - Bayer CropScience LP; Determination of Nonregulated Status for Cotton Genetically Engineered for...

    Science.gov (United States)

    2011-10-12

    ... Animal and Plant Health Inspection Service [Docket No. APHIS-2010-0102] Bayer CropScience LP... Tolerance AGENCY: Animal and Plant Health Inspection Service, USDA. ACTION: Notice. SUMMARY: We are advising... Through Genetic Engineering Which Are Plant Pests or Which There Is Reason to Believe Are Plant Pests...

  6. 77 FR 36525 - Cheniere Creole Trail Pipeline Company, L.P.; Notice of Intent To Prepare an Environmental...

    Science.gov (United States)

    2012-06-19

    ... Energy Regulatory Commission Cheniere Creole Trail Pipeline Company, L.P.; Notice of Intent To Prepare an Environmental Assessment for the Proposed Creole Trail Expansion Project and Request for Comments on... environmental assessment (EA) that will discuss the environmental impacts of the Creole Trail Expansion Project...

  7. 78 FR 66911 - Texas Eastern Transmission, LP; Notice of Intent To Prepare an Environmental Assessment for the...

    Science.gov (United States)

    2013-11-07

    ... discuss the environmental impacts of the Emerald Longwall Mine Panel D1 Project in Docket No. CP14-4-000... Energy Regulatory Commission Texas Eastern Transmission, LP; Notice of Intent To Prepare an Environmental Assessment for the Proposed Emerald Longwall Mine Panel D1 and Consol Baily East Mine Panel 1l Projects and...

  8. 78 FR 77770 - Ironwood Equity Fund, LP; Notice Seeking Exemption Under Section 312 of the Small Business...

    Science.gov (United States)

    2013-12-24

    ... Investment Act, Conflicts of Interest Notice is hereby given that Ironwood Equity Fund, LP, 45 Nod Road, Avon... Act and Section 107.730, Financings which Constitute Conflicts of Interest of the Small Business... convertible debt investment in Action Environmental Group, Inc., a portfolio company of its Associate Ironwood...

  9. 75 FR 6414 - Cardinal Growth, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business...

    Science.gov (United States)

    2010-02-09

    ... Act, Conflicts of Interest Notice is hereby given that Cardinal Growth, L.P., 311 South Wacker Driver... Section 312 of the Act and Section 107.730, Financings which Constitute Conflicts of Interest of the Small... financing to GreenRock Environmental Management, Inc., 1400 West Carroll Avenue, Chicago, IL 60607. The...

  10. 76 FR 77298 - Emergence Capital Partners SBIC, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

    Science.gov (United States)

    2011-12-12

    ... Business Investment Act, Conflicts of Interest Notice is hereby given that Ironwood Mezzanine Fund II, L.P... Section 312 of the Act and Section 107.730, Financings which Constitute Conflicts of Interest of the Small.... proposes to provide debt financing to Action Environmental Group, Inc., 451 Frelinghuysen Avenue, Newark...

  11. 75 FR 5634 - Ironwood Mezzanine Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

    Science.gov (United States)

    2010-02-03

    ... Investment Act, Conflicts of Interest Notice is hereby given that Ironwood Mezzanine Fund II, L.P. 200 Fisher... Section 312 of the Act and Section 107.730, Financings which Constitute Conflicts of Interest of the Small.... proposes to provide debt/equity security financing to Action Carting Environmental Services, Inc., 451...

  12. 76 FR 36914 - Astoria Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas...

    Science.gov (United States)

    2011-06-23

    ... Energy Regulatory Commission Astoria Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas Turbine Power LLC, Dunkirk Power LLC, Huntley Power LLC, Oswego Harbor Power LLC, TC..., 2011, Astoria Generating Company, NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas Turbine...

  13. Beyond the floor effect on the Wechsler Intelligence Scale for Children--4th Ed. (WISC-IV): calculating IQ and Indexes of subjects presenting a floored pattern of results.

    Science.gov (United States)

    Orsini, A; Pezzuti, L; Hulbert, S

    2015-05-01

    It is now widely known that children with severe intellectual disability show a 'floor effect' on the Wechsler scales. This effect emerges because the practice of transforming raw scores into scaled scores eliminates any variability present in participants with low intellectual ability and because intelligence quotient (IQ) scores are limited insofar as they do not measure scores lower than 40. Following Hessl et al.'s results, the present authors propose a method for the computation of the Wechsler Intelligence Scale for Children--4th Ed. (WISC-IV)'s IQ and Indexes in intellectually disabled participants affected by a floored pattern of results. The Italian standardization sample (n = 2200) for the WISC-IV was used. The method presented in this study highlights the limits of the 'floor effect' of the WISC-IV in children with serious intellectual disability who present a profile with weighted scores of 1 in all the subtests despite some variability in the raw scores. Such method eliminates the floor effect of the scale and therefore makes it possible to analyse the strengths and weaknesses of the WISC-IV's Indexes in these participants. The Authors reflect on clinical utility of this method and on the meaning of raw score of 0 on subtest. © 2014 MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd.

  14. Energy data base: subject thesaurus

    Energy Technology Data Exchange (ETDEWEB)

    Redford, J.S. (ed.)

    1981-10-01

    The technical staff of the DOE Technical Information Center, during its subject indexing activities, develops and structures a vocabulary that allows consistent machine storage and retrieval of information necessary to the accomplishment of the DOE mission. This thesaurus incorporates that structured vocabulary. The terminology of this thesaurus is used for the subject control of information announced in DOE Energy Research Abstracts, Energy Abstracts for Policy Analysis, and various update journals and bulletins in specialized areas. This terminology also facilitates subject searching of the DOE Energy Data Base on the DOE/RECON on-line retrieval system and on other commercial retrieval systems. The rapid expansion of the DOE's activities will result in a commitant thesaurus expansion as information relating to new activities is indexed. Only the terms used in the indexing of documents at the Technical Information Center to date are included. (JSR)

  15. Index to Selected Outdoor Recreation Literature. Volume I.

    Science.gov (United States)

    Bureau of Outdoor Recreation (Dept. of Interior), Washington, DC.

    A partial index to selected outdoor recreation literature received by the Department of the Interior Library during 1966 provides 991 abstracts retrievable by subject index, name index, geographic index, and publications appendices. Subject categories include outdoor recreation resources, administration of resources and programs, recreation users'…

  16. The impact of active stakeholder involvement on recruitment, retention and engagement of schools, children and their families in the cluster randomised controlled trial of the Healthy Lifestyles Programme (HeLP): a school-based intervention to prevent obesity.

    Science.gov (United States)

    Lloyd, J; McHugh, C; Minton, J; Eke, H; Wyatt, K

    2017-08-14

    Recruitment and retention of participants is crucial for statistical power and internal and external validity and participant engagement is essential for behaviour change. However, many school-based interventions focus on programme content rather than the building of supportive relationships with all participants and tend to employ specific standalone strategies, such as incentives, to improve retention. We believe that actively involving stakeholders in both intervention and trial design improves recruitment and retention and increases the chances of creating an effective intervention. The Healthy Lifestyles Programme, HeLP (an obesity prevention programme for children 9-10 years old) was developed using intervention mapping and involved extensive stakeholder involvement in both the design of the trial and the intervention to ensure that: (i) delivery methods were suitably engaging, (ii) deliverers had the necessary skills and qualities to build relationships and (iii) the intervention dovetailed with the National Curriculum. HeLP was a year-long intervention consisting of 4 multi-component phases using a range of delivery methods. We recruited 1324 children from 32 schools from the South West of England to a cluster-randomised controlled trial to determine the effectiveness of HeLP in preventing obesity. The primary outcome was change in body mass index standard deviation score (BMI SDS) at 24 months post randomisation. Secondary outcomes included additional anthropometric and behavioural (physical activity and diet) measures at 18 and 24 months. Anthropometric and behavioural measures were taken in 99%, 96% and 94% of children at baseline, 18 and 24 months, respectively, with no differential follow up between the control and intervention groups at each time point. All children participated in the programme and 92% of children and 77% of parents across the socio-economic spectrum were considered to have actively engaged with HeLP. We attribute our excellent

  17. Dendrophysiological plant strategies of Poincianella pyramidalis (Tul. L.P. Queiroz after wood herbivory in semiarid region of Paraíba - Brazil

    Directory of Open Access Journals (Sweden)

    Otacilio Antunes Santana

    2016-10-01

    Full Text Available The increase in Equus africanus asinus Linnaeus population in semiarid areas of Northeast Brazil had significant impacts on wild and rural areas. The objective of this work was to analyze the herbivory of E. africanus asinus on Poincianella pyramidalis (Tul. L.P. Queiroz and determine the dendrophysiological strategies P. pyramidalis used during and after damage caused by E. africanus asinus. The selected areas have significant populations of P. pyramidalis with amplified importance value higher than 50%. Two areas were established: one control and another experimental, with presence of E. africanus asinus. The study was carried out from 2001 to 2015. The evaluated variables of P. pyramidalis were: sap flow, basic density, diameter, volume, biomass and leaf area index. The increase of abandoned E. africanus asinus in semiarid areas resulted in impact and responses from P. pyramidalis. This plant species compensates for biomass losses and physiological activities reduction with two strategies: i increase in the belowground biomass stock, and ii increase in sap flow in undisturbed branches.

  18. Consuming a mixed diet enriched with lupin protein beneficially affects plasma lipids in hypercholesterolemic subjects: a randomized controlled trial.

    Science.gov (United States)

    Bähr, Melanie; Fechner, Anita; Kiehntopf, Michael; Jahreis, Gerhard

    2015-02-01

    The objectives of this study were to assess whether 25 g/d lupin protein, integrated into a mixed diet, might affect cardiovascular risk factors and whether l-arginine was responsible for these effects. Seventy-two hypercholesterolemic subjects participated in the randomized, controlled, double-blind three-phase crossover study. They were assigned to three diets with 25 g/d lupin protein (LP), milk protein (MP) or milk protein plus 1.6 g/d arginine (MPA) each for 28 d in a random order interrupted by 6-week washout periods. Lupin protein and the comparator milk protein were incorporated into complex food products (bread, roll, sausage, and vegetarian spread). Arginine was administered via capsules. Sixty-eight subjects were included in final analyses. Compared with MP, LDL cholesterol was significantly lower after LP. Compared with MP and MPA, homocysteine was significantly lower after LP. Compared with baseline, concentrations of total, LDL, and HDL cholesterol significantly decreased after LP and MPA. Triacylglycerols and uric acid significantly decreased after LP. The relative changes in total and LDL cholesterol were significantly greater for subjects with severe hypercholesterolemia (>6.6 mmol/L) than those with moderate hypercholesterolemia (5.2-6.6 mmol/L). The present study showed for the first time that incorporation of 25 g/d of lupin protein into a variety of complex food products lowers total and LDL cholesterol, triacylglycerols, homocysteine, and uric acid in hypercholesterolemic subjects. The hypocholesterolemic effect is stronger in subjects with severe hypercholesterolemia. Arginine might be responsible for some, but not all of the beneficial effects of lupin protein. This trial was registered at http://clinicaltrials.gov (study ID number NCT01598649). Copyright © 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  19. Variation in LPA is associated with Lp(a levels in three populations from the Third National Health and Nutrition Examination Survey.

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    Logan Dumitrescu

    2011-01-01

    Full Text Available The distribution of lipoprotein(a [Lp(a] levels can differ dramatically across diverse racial/ethnic populations. The extent to which genetic variation in LPA can explain these differences is not fully understood. To explore this, 19 LPA tagSNPs were genotyped in 7,159 participants from the Third National Health and Nutrition Examination Survey (NHANES III. NHANES III is a diverse population-based survey with DNA samples linked to hundreds of quantitative traits, including serum Lp(a. Tests of association between LPA variants and transformed Lp(a levels were performed across the three different NHANES subpopulations (non-Hispanic whites, non-Hispanic blacks, and Mexican Americans. At a significance threshold of p<0.0001, 15 of the 19 SNPs tested were strongly associated with Lp(a levels in at least one subpopulation, six in at least two subpopulations, and none in all three subpopulations. In non-Hispanic whites, three variants were associated with Lp(a levels, including previously known rs6919246 (p = 1.18 × 10(-30. Additionally, 12 and 6 variants had significant associations in non-Hispanic blacks and Mexican Americans, respectively. The additive effects of these associated alleles explained up to 11% of the variance observed for Lp(a levels in the different racial/ethnic populations. The findings reported here replicate previous candidate gene and genome-wide association studies for Lp(a levels in European-descent populations and extend these findings to other populations. While we demonstrate that LPA is an important contributor to Lp(a levels regardless of race/ethnicity, the lack of generalization of associations across all subpopulations suggests that specific LPA variants may be contributing to the observed Lp(a between-population variance.

  20. Automatic inference of indexing rules for MEDLINE

    Directory of Open Access Journals (Sweden)

    Shooshan Sonya E

    2008-11-01

    Full Text Available Abstract Background: Indexing is a crucial step in any information retrieval system. In MEDLINE, a widely used database of the biomedical literature, the indexing process involves the selection of Medical Subject Headings in order to describe the subject matter of articles. The need for automatic tools to assist MEDLINE indexers in this task is growing with the increasing number of publications being added to MEDLINE. Methods: In this paper, we describe the use and the customization of Inductive Logic Programming (ILP to infer indexing rules that may be used to produce automatic indexing recommendations for MEDLINE indexers. Results: Our results show that this original ILP-based approach outperforms manual rules when they exist. In addition, the use of ILP rules also improves the overall performance of the Medical Text Indexer (MTI, a system producing automatic indexing recommendations for MEDLINE. Conclusion: We expect the sets of ILP rules obtained in this experiment to be integrated into MTI.

  1. Automatic inference of indexing rules for MEDLINE.

    Science.gov (United States)

    Névéol, Aurélie; Shooshan, Sonya E; Claveau, Vincent

    2008-11-19

    Indexing is a crucial step in any information retrieval system. In MEDLINE, a widely used database of the biomedical literature, the indexing process involves the selection of Medical Subject Headings in order to describe the subject matter of articles. The need for automatic tools to assist MEDLINE indexers in this task is growing with the increasing number of publications being added to MEDLINE. In this paper, we describe the use and the customization of Inductive Logic Programming (ILP) to infer indexing rules that may be used to produce automatic indexing recommendations for MEDLINE indexers. Our results show that this original ILP-based approach outperforms manual rules when they exist. In addition, the use of ILP rules also improves the overall performance of the Medical Text Indexer (MTI), a system producing automatic indexing recommendations for MEDLINE. We expect the sets of ILP rules obtained in this experiment to be integrated into MTI.

  2. Trial baseline characteristics of a cluster randomised controlled trial of a school-located obesity prevention programme; the Healthy Lifestyles Programme (HeLP trial

    Directory of Open Access Journals (Sweden)

    Jenny Lloyd

    2017-04-01

    Full Text Available Abstract Background We have developed a healthy lifestyles programme (HeLP for primary school aged children (9–10 years, currently being evaluated in a definitive cluster randomised controlled trial. This paper descriptively presents the baseline characteristics of trial children (BMI, waist circumference, % body fat, diet and physical activity by gender, cluster level socio-economic status, school size and time of recruitment into the trial. Methods Schools were recruited from across the South West of England and allocated 1:1 to either intervention (HeLP or control (usual practice stratified by the proportion of children eligible for free school meals (FSM, 1 Year 5 class. The primary outcome is change in body mass index standard deviation score (BMI sds at 24 months post-randomisation. Secondary outcomes are BMI sds at 18 months, waist circumference and percentage body fat sds at 18 and 24 months, proportion of children classified as underweight, overweight and obese at 18 and 24 months, physical activity (for a sub-sample and food intake at 18 months. Results At baseline 11.4% and 13.6% of children were categorised as overweight or obese respectively. A higher percentage of girls than boys (25.3% vs 24.8% and children from schools in FSM category 2 (28.2% vs 23.2% were overweight or obese. Children were consuming a mean (range of 4.15 (0–13 energy dense snacks (EDS and 3.23 (0–9 healthy snacks (HS per day with children from schools in FSM category 2 consuming more EDS and negative food markers and less HS and positive food markers. Children spent an average 53.6 min per day (11.9 to 124.8 in MVPA and thirteen hours (779.3 min per day (11 h to 15 h doing less than ‘light’ intensity activity. Less than 5% of children achieved the Departments of Health’s recommendation of 60 min of MVPA every day. Conclusion We have excellent completeness of baseline data for all measures and have achieved compliance to accelerometry not

  3. Processing and targeting of proteins derived from polyprotein with 2A and LP4/2A as peptide linkers in a maize expression system.

    Directory of Open Access Journals (Sweden)

    He Sun

    Full Text Available In the transformation of multiple genes, gene fusion is an attractive alternative to other methods, including sexual crossing, re-transformation, and co-transformation, among others. The 2A peptide from the foot-and-mouth disease virus (FMDV causes the co-translational "cleavage" of polyprotein and operates in a wide variety of eukaryotic cells. LP4, a linker peptide that originates from a natural polyprotein occurring in the seed of Impatiens balsamina, can be split between the first and second amino acids in post-translational processing. LP4/2A is a hybrid linker peptide that contains the first nine amino acids of LP4 and 20 amino acids of 2A. The three linkers have been used as a suitable technique to link the expression of genes in some transgenic plants, but to date the cleavage efficiency of three linkers have not been comprehensively demonstrated in the same transformation system, especially in the staple crop. To verify the functions of 2A, LP4, and LP4/2A linker peptides in transgenic maize, six fusion protein vectors that each encoded a single open reading frame (ORF incorporating two report genes, Green Fluorescent Protein (GFP and β-glucuronidase (GUS, separated by 2A (or modified 2A, LP4 or LP4/2A were assembled to compare the cleavage efficiency of the three linkers in a maize transient expression system. The results demonstrated the more protein production and higher cleavage splicing efficiency with the polyprotein construct linked by the LP4/2A peptide than those of the polyprotein constructs linked by 2A or LP4 alone. Seven other fusion proteins that each encoded a single ORF incorporating two different genes GFP and Red Fluorecent Protein (RFP with different signal peptides were assembled to study the subcellular localization of genes linked by LP4/2A. The subcellular localization experiments suggested that both types of signal peptide, co-translational and post-translational, could lead their proteins to the target

  4. Modulation of phosducin-like protein 3 (PhLP3 levels promotes cytoskeletal remodelling in a MAPK and RhoA-dependent manner.

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    Nandini V L Hayes

    Full Text Available BACKGROUND: Phosducin-like protein 3 (PhLP3 forms a ternary complex with the ATP-dependent molecular chaperone CCT and its folding client tubulin. In vitro studies suggest PhLP3 plays an inhibitory role in β-tubulin folding while conversely in vivo genetic studies suggest PhLP3 is required for the correct folding of β-tubulin. We have a particular interest in the cytoskeleton, its chaperones and their role in determining cellular phenotypes associated with high level recombinant protein expression from mammalian cell expression systems. METHODOLOGY/PRINCIPAL FINDINGS: As studies into PhLP3 function have been largely carried out in non mammalian systems, we examined the effect of human PhLP3 over-expression and siRNA silencing using a single murine siRNA on both tubulin and actin systems in mammalian Chinese hamster ovary (CHO cell lines. We show that over-expression of PhLP3 promotes an imbalance of α and β tubulin subunits, microtubule disassembly and cell death. In contrast, β-actin levels are not obviously perturbed. On-the-other-hand, RNA silencing of PhLP3 increases RhoA-dependent actin filament formation and focal adhesion formation and promotes a dramatic elongated fibroblast-like change in morphology. This was accompanied by an increase in phosphorylated MAPK which has been associated with promoting focal adhesion assembly and maturation. Transient overexpression of PhLP3 in knockdown experiments rescues cells from the morphological change observed during PhLP3 silencing but mitosis is perturbed, probably reflecting a tipping back of the balance of PhLP3 levels towards the overexpression state. CONCLUSIONS: Our results support the hypothesis that PhLP3 is important for the maintenance of β-tubulin levels in mammalian cells but also that its modulation can promote actin-based cytoskeletal remodelling by a mechanism linked with MAPK phosphorylation and RhoA-dependent changes. PhLP3 levels in mammalian cells are thus finely poised and

  5. DETERMINATION OF LEVEL OF FOOD ADDITIVES IN Labisia pumila (LP BEVERAGES CONSUMED IN KUANTAN, MALAYSIA

    Directory of Open Access Journals (Sweden)

    Ade Chandra Iwansyah

    2013-03-01

    Full Text Available The content levels of several food additives (gallic acid, benzoic acid and caffeine in commercial Labisia pumila (LP beverage samples in Kuantan, Malaysia were determined by high performances liquid chromatography (HPLC. These analytical measurements were undertaken primarily to assess the compliance of content levels of the investigated food additives and their daily intake doses with permissible levels. The results obtained from this study indicated that the average levels of GA, caffeine and benzoic acid in the analyzed beverages were 37.62-229.35 ppm, 43.46 -168.00 ppm and 98.10-241.13 ppm, respectively. In addition, the concentrations of these food additives have been converted into daily intake doses based on beverage consumption. It was estimated that the mean daily intake of GA, caffeine and benzoic acid  by the adult population of Kuantan through the consumption of the analyzed beverages  were 0.39 mg/kg body weight/day for GA, 0.59 mg/kg body weight/day for caffeine (19.6 % ADI and 0.43 mg/kg body weight/day for benzoic acid (8.6%ADI. None of the analyzed beverage sample was found to violate the current legal limits as stipulated in Malaysian food regulation.   Keywords: beverages, daily intake, food additives, Labisia pumila

  6. lpNet: a linear programming approach to reconstruct signal transduction networks.

    Science.gov (United States)

    Matos, Marta R A; Knapp, Bettina; Kaderali, Lars

    2015-10-01

    With the widespread availability of high-throughput experimental technologies it has become possible to study hundreds to thousands of cellular factors simultaneously, such as coding- or non-coding mRNA or protein concentrations. Still, extracting information about the underlying regulatory or signaling interactions from these data remains a difficult challenge. We present a flexible approach towards network inference based on linear programming. Our method reconstructs the interactions of factors from a combination of perturbation/non-perturbation and steady-state/time-series data. We show both on simulated and real data that our methods are able to reconstruct the underlying networks fast and efficiently, thus shedding new light on biological processes and, in particular, into disease's mechanisms of action. We have implemented the approach as an R package available through bioconductor. This R package is freely available under the Gnu Public License (GPL-3) from bioconductor.org (http://bioconductor.org/packages/release/bioc/html/lpNet.html) and is compatible with most operating systems (Windows, Linux, Mac OS) and hardware architectures. bettina.knapp@helmholtz-muenchen.de Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  7. Three small transiting planets around the M-dwarf host star LP 358-499

    Science.gov (United States)

    Wells, R.; Poppenhaeger, K.; Watson, C. A.

    2018-01-01

    We report on the detection of three transiting small planets around the low-mass star LP 358-499 (K2-133), using photometric data from the Kepler-K2 mission. Using multiband photometry, we determine the host star to be an early M dwarf with an age likely older than a gigayear. The three detected planets K2-133 b, c and d have orbital periods of ca. 3, 4.9 and 11 d and transit depths of ca. 700, 1000 and 2000 ppm, respectively. We also report a planetary candidate EPIC 247887989.01 with a period of 26.6 d and a depth of ca. 1000 ppm, which may be at the inner edge of the stellar habitable zone, depending on the specific host star properties. Using the transit parameters and the stellar properties, we estimate that the innermost planet may be rocky. The system is suited for follow-up observations to measure planetary masses and JWST transmission spectra of planetary atmospheres.

  8. Interaction of a model apolipoprotein, apoLp-III, with an oil-phospholipid interface.

    Science.gov (United States)

    Mirheydari, Mona; Mann, Elizabeth K; Kooijman, Edgar E

    2017-10-10

    Lipid droplets are "small" organelles that play an important role in de novo synthesis of new membrane, and steroid hormones, as well as in energy storage. The way proteins interact specifically with the oil-(phospho-)lipid monolayer interface of lipid droplets is a relatively unexplored but crucial question. Here, we use our home built liquid droplet tensiometer to mimic intracellular lipid droplets and study protein-lipid interactions at this interface. As model neutral lipid binding protein, we use apoLp-III, an amphipathic α-helix bundle protein. This domain is also found in proteins from the perilipin family and in apoE. Protein binding to the monolayer is studied by the decrease in the oil/water surface tension. Previous work used POPC (one of the major lipids found on lipid droplets) to form the phospholipid monolayer on the triolein surface. Here we expand this work by incorporating other lipids with different physico-chemical properties to study the effect of charge and lipid head-group size. This study sheds light on the affinity of this important protein domain to interact with lipids. Copyright © 2017. Published by Elsevier B.V.

  9. Evaluation of Llaima volcano activities for localization and classification of LP, VT and TR events

    Science.gov (United States)

    Dehghan Firoozabadi, Ali; Seguel, Fabian; Soto, Ismael; Guevara, David; Huenupan, Fernando; Curilem, Millaray; Franco, Luis

    2017-09-01

    Evaluation of seismic signals is one of the most important research topics on Volcanology. Volcanoes have daily activity; therefore, high speed evaluation of recorded signals is a challenge for improving the study of the natural phenomena occurring inside these natural formations. The aim of this paper is the evaluation (denoising, localization and classification) and analysis of Llaima volcano activities, one of the most actives volcanoes in South America. Different already proposed methods, such as, Butterworth, Spectral Subtraction (SS) and Wiener Filter (WF) are compared to the proposed Modified Spectral Subtraction (MSS) and Modified Wiener Filter (MWF) to find the best method for denoising the volcano signals. Then, event localization based on received signals of volcano is performed. In this step, Time Delay Estimation (TDE)-based method is used on data acquired from 3 mechanical sensors located in the volcano area. The proposed method is used to estimate the area for event location. The proposed denoising methods make the starting point for the event more evident to increase the localization accuracy for events where the starting point is difficult to find. In the last step, a method based on the novel DNN technique is proposed to classify the three main events occurring in the Llaima volcano (TR (Tremor), LP (Long Period) and VT (Volcano Tectonic)).

  10. Browse Author Index

    African Journals Online (AJOL)

    Items 1 - 50 of 114 ... Basheer, Ayoub B.M. · Batubenge, Augustin T · Batubenge, T A · Batubenge, T. Augustin · Baxter, M · Bárcenas, D · Bárcenas, Diómedes · Bárcenas, Diómedes · Bárcenas, Diomedes · Beanland, Kevin · Behrendt, D · Beik, S.P.A. · Bella, Angelo · Belluce, LP · Bencherif, F. Bendoukha, B · Benferhat, Leila

  11. Sensitivity analysis for CORSOR models simulating fission product release in LOFT-LP-FP-2 severe accident experiment

    Energy Technology Data Exchange (ETDEWEB)

    Hoseyni, Seyed Mohsen [Islamic Azad Univ., Tehran (Iran, Islamic Republic of). Dept. of Basic Sciences; Islamic Azad Univ., Tehran (Iran, Islamic Republic of). Young Researchers and Elite Club; Pourgol-Mohammad, Mohammad [Sahand Univ. of Technology, Tabriz (Iran, Islamic Republic of). Dept. of Mechanical Engineering; Yousefpour, Faramarz [Nuclear Science and Technology Research Institute, Tehran (Iran, Islamic Republic of)

    2017-03-15

    This paper deals with simulation, sensitivity and uncertainty analysis of LP-FP-2 experiment of LOFT test facility. The test facility simulates the major components and system response of a pressurized water reactor during a LOCA. MELCOR code is used for predicting the fission product release from the core fuel elements in LOFT LP-FP-2 experiment. Moreover, sensitivity and uncertainty analysis is performed for different CORSOR models simulating release of fission products in severe accident calculations for nuclear power plants. The calculated values for the fission product release are compared under different modeling options to the experimental data available from the experiment. In conclusion, the performance of 8 CORSOR modeling options is assessed for available modeling alternatives in the code structure.

  12. Strategic planning for minimizing CO2 emissions using LP model based on forecasted energy demand by PSO Algorithm and ANN

    Energy Technology Data Exchange (ETDEWEB)

    Yousefi, M.; Omid, M.; Rafiee, Sh. [Department of Agricultural Machinery Engineering, University of Tehran, Karaj (Iran, Islamic Republic of); Ghaderi, S.F. [Department of Industrial Engineering, University of Tehran, Tehran (Iran, Islamic Republic of)

    2013-07-01

    Iran's primary energy consumption (PEC) was modeled as a linear function of five socioeconomic and meteorological explanatory variables using particle swarm optimization (PSO) and artificial neural networks (ANNs) techniques. Results revealed that ANN outperforms PSO model to predict test data. However, PSO technique is simple and provided us with a closed form expression to forecast PEC. Energy demand was forecasted by PSO and ANN using represented scenario. Finally, adapting about 10% renewable energy revealed that based on the developed linear programming (LP) model under minimum CO2 emissions, Iran will emit about 2520 million metric tons CO2 in 2025. The LP model indicated that maximum possible development of hydropower, geothermal and wind energy resources will satisfy the aim of minimization of CO2 emissions. Therefore, the main strategic policy in order to reduce CO2 emissions would be exploitation of these resources.

  13. Relations between a novel, reliable, and rapid index of arterial compliance (PP-HDI) and well-established inidices of arterial blood pressure (ABP) in a sample of hypertensive elderly subjects.

    Science.gov (United States)

    Bergamini, L; Finelli, M E; Bendini, C; Ferrari, E; Veschi, M; Neviani, F; Manni, B; Pelosi, A; Rioli, G; Neri, M

    2009-01-01

    Hypertension is a risk factor for a long-lasting arterial wall-remodelling leading to stiffness. The rapid method measuring the pulse pressure (PP) by means of the tool of Hypertension Diagnostic Instruments (HDI) called PP-HDI, overcomes some of the problems arising with more-time consuming methods, like ambulatory blood pressure monitoring (ABPM), and give information about the elasticity of the arterial walls. We studied the relationship between the PP-HDI, the large artery compliance (LA-C) and small artery compliance (SA-C) and few well-established indices of arterial blood pressure (ABP) in a sample of 75 hypertensive subjects, aged 65 years and over. Significant correlations between LA-C and heart rate (HR), PP-ABPM and PP-HDI were found. SA-C relates with HR and systolic blood pressure (SBP) measured in lying and standing positions. Applying a stepwise regression analysis, we found that LA-C variance stems from PP-HDI and HR, while SA-C variance stems from SBP in lying position. Receiver operator characteristic (ROC) curves for thresholds of PP showed that PP-HDI reached levels of sensitivity/specificity similar to PP-ABPM. In conclusion, surveillance of ABP through hemo-dynamic indices, in particular of SBP, is essential, nevertheless the advantage of this control is not known in an elderly population where the organ damage is already evident. PP needs necessarily an instrumental measurement. The PP-HDI result is similar in reliability with respect to PPABPM, but is more rapid and well applicable in an elderly population.

  14. Thermal–hydraulic system study of the HELOKA-LP helium loop using RELAP5-3D code

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Xue Zhou, E-mail: jin@kit.edu; Schlindwein, Georg; Schlenker, Markus; Ghidersa, Bradut-Eugen; Chen, Yuming; Arbeiter, Frederik

    2013-10-15

    Highlights: • Thermal–hydraulic system study for the HELOKA-LP using RELAP5-3D. • Validation of various experiments with corresponding simulations, and good comparison between the experiments and the simulations. • Simulation of the two most heated compartments of IFMIF HFTM in the modeled helium loop and prediction of the loop dynamic. -- Abstract: The thermal–hydraulic system analyses for the HELOKA-LP (Helium Loop Karlsruhe – Low Pressure) facility are presented. Typical operation ranges for the test section are mass flow rate between 12 and 120 g/s, inlet temperature between 10 and 250 °C and pressure level between 0.3 and 0.6 MPa. An orifice is used for the loop testing, for which different experiments are validated with appropriate simulations. Afterwards instead of the orifice, two most heated compartments of IFMIF (International Fusion Materials Irradiation Facility) HFTM (high flux test module) are simulated in HELOKA-LP. Using the system code REALP5-3D components in the loop are modeled as well as the main control strategy. With this model the loop dynamics in conditions relevant for the HFTM operation are analyzed and the thermal time constant of the compartment is estimated.

  15. Neural substrates of normal and impaired preattentive sensory discrimination in large cohorts of nonpsychiatric subjects and schizophrenia patients as indexed by MMN and P3a change detection responses.

    Science.gov (United States)

    Takahashi, Hidetoshi; Rissling, Anthony J; Pascual-Marqui, Roberto; Kirihara, Kenji; Pela, Marlena; Sprock, Joyce; Braff, David L; Light, Gregory A

    2013-02-01

    Schizophrenia (SZ) patients have information processing deficits, spanning from low level sensory processing to higher-order cognitive functions. Mismatch negativity (MMN) and P3a are event-related potential (ERP) components that are automatically elicited in response to unattended changes in ongoing, repetitive stimuli that provide a window into abnormal information processing in SZ. MMN and P3a are among the most robust and consistently identified deficits in SZ, yet the neural substrates of these responses and their associated deficits in SZ are not fully understood. This study examined the neural sources of MMN and P3a components in a large cohort of SZ and nonpsychiatric control subjects (NCS) using Exact Low Resolution Electromagnetic Tomography Analyses (eLORETA) in order to identify the neural sources of MMN and P3a as well as the brain regions associated with deficits commonly observed among SZ patients. 410 SZ and 247 NCS underwent EEG testing using a duration-deviant auditory oddball paradigm (1-kHz tones, 500ms SOA; standard p=0.90, 50-ms duration; deviant tones P=0.10, 100-ms duration) while passively watching a silent video. Voxel-by-voxel within- (MMN vs. P3a) and between-group (SZ vs. NCS) comparisons were performed using eLORETA. SZ had robust deficits in MMN and P3a responses measured at scalp electrodes consistent with other studies. These components mapped onto neural sources broadly distributed across temporal, frontal, and parietal regions. MMN deficits in SZ were associated with reduced activations in discrete medial frontal brain regions, including the anterior-posterior cingulate and medial frontal gyri. These early sensory discriminatory MMN impairments were followed by P3a deficits associated with widespread reductions in the activation of attentional networks (frontal, temporal, parietal regions), reflecting impaired orienting or shifts of attention to the infrequent stimuli. MMN and P3a are dissociable responses associated with broadly

  16. Neural substrates of normal and impaired preattentive sensory discrimination in large cohorts of nonpsychiatric subjects and schizophrenia patients as indexed by MMN and P3a change detection responses☆

    Science.gov (United States)

    Takahashi, Hidetoshi; Rissling, Anthony J.; Pascual-Marqui, Roberto; Kirihara, Kenji; Pela, Marlena; Sprock, Joyce; Braff, David L.; Light, Gregory A.

    2013-01-01

    Objective Schizophrenia (SZ) patients have information processing deficits, spanning from low level sensory processing to higher-order cognitive functions. Mismatch negativity (MMN) and P3a are event-related potential (ERP) components that are automatically elicited in response to unattended changes in ongoing, repetitive stimuli that provide a window into abnormal information processing in SZ. MMN and P3a are among the most robust and consistently identified deficits in SZ, yet the neural substrates of these responses and their associated deficits in SZ are not fully understood. This study examined the neural sources of MMN and P3a components in a large cohort of SZ and nonpsychiatric control subjects (NCS) using Exact Low Resolution Electromagnetic Tomography Analyses (eLORETA) in order to identify the neural sources of MMN and P3a as well as the brain regions associated with deficits commonly observed among SZ patients. Methods 410 SZ and 247 NCS underwent EEG testing using a duration-deviant auditory oddball paradigm (1-kHz tones, 500 ms SOA; standard p=0.90, 50-ms duration; deviant tones P=0.10, 100-ms duration) while passively watching a silent video. Voxel-by-voxel within- (MMN vs. P3a) and between-group (SZ vs. NCS) comparisons were performed using eLORETA. Results SZ had robust deficits in MMN and P3a responses measured at scalp electrodes consistent with other studies. These components mapped onto neural sources broadly distributed across temporal, frontal, and parietal regions. MMN deficits in SZ were associated with reduced activations in discrete medial frontal brain regions, including the anterior–posterior cingulate and medial frontal gyri. These early sensory discriminatory MMN impairments were followed by P3a deficits associated with widespread reductions in the activation of attentional networks (frontal, temporal, parietal regions), reflecting impaired orienting or shifts of attention to the infrequent stimuli. Conclusions MMN and P3a are

  17. 76 FR 76802 - Riverside Micro-Cap Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

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    2011-12-08

    ... 77067 (``DISA''). The financing is brought within the purview of Sec. 107.730(a) and (d) of the... Riverside Micro-Cap Fund II, L.P., own more than ten percent of DISA, and therefore this transaction is...

  18. Integrating theory and data to create an online self-management programme for adults with type 2 diabetes: HeLP-Diabetes

    Directory of Open Access Journals (Sweden)

    Kingshuk Pal

    2015-10-01

    This protocol demonstrates a multi-disciplinary approach to combining evidence from multiple sources to create ’HeLP-Diabetes’: a theory and evidence based online self-management intervention for adults with type 2 diabetes.

  19. The obesity and fatty liver are reduced by plant-derived Pediococcus pentosaceus LP28 in high fat diet-induced obese mice.

    Directory of Open Access Journals (Sweden)

    Xingrong Zhao

    Full Text Available We evaluated the effect of an oral administration of a plant-derived lactic acid bacterium, Pediococcus pentosaceus LP28 (LP28, on metabolic syndrome by using high fat diet-induced obese mice. The obese mice were divided into 2 groups and fed either a high fat or regular diet for 8 weeks. Each group was further divided into 3 groups, which took LP28, another plant-derived Lactobacillus plantarum SN13T (SN13T or no lactic acid bacteria (LAB. The lean control mice were fed a regular diet without inducing obesity prior to the experiment. LP28 reduced body weight gain and liver lipid contents (triglyceride and cholesterol, in mice fed a high fat diet for 8 weeks (40%, 54%, and 70% less than those of the control group without LAB, and P = 0.018, P<0.001, and P = 0.021, respectively, whereas SN13T and the heat treated LP28 at 121°C for 15 min were ineffective. Abdominal visceral fat in the high fat diet mice fed with LP28 was also lower than that without LAB by 44%, although it was not significant but borderline (P = 0.076. The sizes of the adipocytes and the lipid droplets in the livers were obviously decreased. A real-time PCR analyses showed that lipid metabolism-related genes, such as CD36 (P = 0.013, SCD1 encoding stearoyl-CoA desaturase 1 (not significant but borderline, P = 0.066, and PPARγ encoding peroxisome proliferator-activated receptor gamma (P = 0.039, were down-regulated by taking LP28 continuously, when compared with those of the control group. In conclusion, LP28 may be a useful LAB strain for the prevention and reduction of the metabolic syndrome.

  20. Reciprocal relationship of T regulatory cells and monocytic myeloid-derived suppressor cells in LP-BM5 murine retrovirus-induced immunodeficiency.

    Science.gov (United States)

    O'Connor, Megan A; Vella, Jennifer L; Green, William R

    2016-02-01

    Immunomodulatory cellular subsets, including myeloid-derived suppressor cells (MDSCs) and T regulatory cells (Tregs), contribute to the immunosuppressive tumour microenvironment and are targets of immunotherapy, but their role in retroviral-associated immunosuppression is less well understood. Due to known crosstalk between Tregs and MDSCs in the tumour microenvironment, and also their hypothesized involvement during human immunodeficiency virus/simian immunodeficiency virus infection, studying the interplay between these immune cells during LP-BM5 retrovirus-induced murine AIDS is of interest. IL-10-producing FoxP3+ Tregs expanded after LP-BM5 infection. Following in vivo adoptive transfer of natural Treg (nTreg)-depleted CD4+T-cells, and subsequent LP-BM5 retroviral infection, enriched monocytic MDSCs (M-MDSCs) from these nTreg-depleted mice displayed altered phenotypic subsets. In addition, M-MDSCs from LP-BM5-infected nTreg-depleted mice exhibited increased suppression of T-cell, but not B-cell, responses, compared with M-MDSCs derived from non-depleted LP-BM5-infected controls. Additionally, LP-BM5-induced M-MDSCs modulated the production of IL-10 by FoxP3+ Tregs in vitro. These collective data highlight in vitro and for the first time, to the best of our knowledge, in vivo reciprocal modulation between retroviral-induced M-MDSCs and Tregs, and may provide insight into the immunotherapeutic targeting of such regulatory cells during retroviral infection.

  1. Scientific Journal Indexing

    Directory of Open Access Journals (Sweden)

    Getulio Teixeira Batista

    2007-08-01

    Full Text Available It is quite impressive the visibility of online publishing compared to offline. Lawrence (2001 computed the percentage increase across 1,494 venues containing at least five offline and five online articles. Results shown an average of 336% more citations to online articles compared to offline articles published in the same venue. If articles published in the same venue are of similar quality, then they concluded that online articles are more highly cited because of their easier access. Thomson Scientific, traditionally concerned with printed journals, announced on November 28, 2005, the launch of Web Citation Index™, the multidisciplinary citation index of scholarly content from institutional and subject-based repositories (http://scientific.thomson. com/press/2005/8298416/. The Web Citation Index from the abstracting and indexing (A&I connects together pre-print articles, institutional repositories and open access (OA journals (Chillingworth, 2005. Basically all research funds are government granted funds, tax payer’s supported and therefore, results should be made freely available to the community. Free online availability facilitates access to research findings, maximizes interaction among research groups, and optimizes efforts and research funds efficiency. Therefore, Ambi-Água is committed to provide free access to its articles. An important aspect of Ambi-Água is the publication and management system of this journal. It uses the Electronic System for Journal Publishing (SEER - http://www.ibict.br/secao.php?cat=SEER. This system was translated and customized by the Brazilian Institute for Science and Technology Information (IBICT based on the software developed by the Public Knowledge Project (Open Journal Systems of the British Columbia University (http://pkp.sfu.ca/ojs/. The big advantage of using this system is that it is compatible with the OAI-PMH protocol for metadata harvesting what greatly promotes published articles

  2. Indexes to Nuclear Regulatory Commission Issuances, January 1996--June 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-09-01

    Digests and indexes for issuances of the Commission, the Atomic Safety and Licensing Board Panel, The Administrative Law Judges, the Director`s Decisions, and the Decisions on Petitions for Rulemaking are presented in this document. The digests and indexes are intended to serve as a guide to the issuances. Information elements common the cases hear and ruled upon are displayed in one or more of five formats: case name index, headers and digests, legal citations index, subject index, and facility index.

  3. In-line optofluidic refractive index sensing in a side-channel photonic crystal fiber.

    Science.gov (United States)

    Zhang, Nan; Humbert, Georges; Wu, Zhifang; Li, Kaiwei; Shum, Perry Ping; Zhang, Nancy Meng Ying; Cui, Ying; Auguste, Jean-Louis; Dinh, Xuan Quyen; Wei, Lei

    2016-11-28

    An in-line optofluidic refractive index (RI) sensing platform is constructed by splicing a side-channel photonic crystal fiber (SC-PCF) with side-polished single mode fibers. A long-period grating (LPG) combined with an intermodal interference between LP01 and LP11 core modes is used for sensing the RI of the liquid in the side channel. The resonant dip shows a nonlinear wavelength shift with increasing RI over the measured range from 1.3330 to 1.3961. The RI response of this sensing platform for a low RI range of 1.3330-1.3780 is approximately linear, and exhibits a sensitivity of 1145 nm/RIU. Besides, the detection limit of our sensing scheme is improved by around one order of magnitude by introducing the intermodal interference.

  4. Page 1 Subject Index 727 Periodic density distribution Periodic ...

    Indian Academy of Sciences (India)

    Precession photography of fibres: Prediction of patterns 415. Proton linear accelerator. Design studies of a 100 MeV proton linear accel- erator 257. Proximity effect. Structural instability and superconductivity in niobium-titanium alloys 555. Pseudo-random sequences. Implementation and comparative study of ran-.

  5. S¯adhan¯a Vol. 35, 2010 Subject Index

    Indian Academy of Sciences (India)

    for commercial vehicle clutch system. 585. CNC end milling. Optimization in CNC end milling of UNS ... Electric field effects. Influence of unbalanced voltages on the movement of metallic particle in a three phase common enclosure gas insulated busduct. 393. Electromagnet. Design, fabrication, and characterization of a.

  6. S¯adhan¯a Vol. 33, 2008 Subject Index

    Indian Academy of Sciences (India)

    Elasto-plastic strain analysis. Elasto-plastic strain analysis by a semi- analytical method. 403. Electric vehicle drive. The differential induction machine: Theory and performance. 663. Electronic packaging. A study aimed at characterizing the interfacial structure in a tin-silver solder on nickel-coated copper plate during aging.

  7. S¯adhan¯a Vol. 38, 2013 Subject Index

    Indian Academy of Sciences (India)

    variable DOF. 247. Gas–liquid phase separation. Entrainment phenomenon in gas–liquid two- phase flow: A review. 1173. Gasification. Biomass-based gasifiers for internal combus- tion (IC) engines—A review. 461. Gauss–Newton method. Flexibility-based structural damage identifica- tion using Gauss–Newton method.

  8. S¯adhan¯a Vol. 30, 2005 Subject Index

    Indian Academy of Sciences (India)

    colony optimization (ACO). Allocation of advertising space by a web ser- vice provider using combinatorial auctions. 213. Association rules. Interestingness of association rules in data mining: Issues relevant to e-commerce 291. Bearing damage.

  9. S¯adhan¯a Vol. 31, 2005 Subject Index

    Indian Academy of Sciences (India)

    Automatic recognition. New method for a person identification sys- tem. 259. Bearing damage. Detection of bearing defects in three-phase induction motors using Park's transform and radical basis function neural networks 235. Bending vibrations. Natural frequencies of a flat viaduct road part simply supported on two ends.

  10. Ax-Ax_12038_Subject index.indd

    Indian Academy of Sciences (India)

    gpc000018295

    H S Gupta, New Delhi. P K Gupta, Meerut. Sanjay Gupta, Navi Mumbai. Stefan T Hertwig, Bern. Thomas H Hintze, Valhalla. Anneli Hoikkala, Jyvaskyla. Judith Humphries, Appleton. Laura A Hyatt, Lawrenceville. Maneesha Inamdar, Bangalore ... Neelam Shirsat, Navi Mumbai. S Shivaji, Hyderabad. K R Shivanna, Bangalore.

  11. S¯adhan¯a Vol. 26, 2001 Subject Index

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    projectile. 379. Automation. A second-order autocorrelator for single-shot measurement of femtosecond laser pulse durations. 603. Axially symmetric bodies. Axial symmetric rotation of a partically immersed body in a liquid with a surfacetant layer. 353. Backpropagation algorithm. Application of chaotic noise reduction tech-.

  12. A Subject Index to Comic Books and Related Material.

    Science.gov (United States)

    Scott, Randall W.

    The original problem of the Special Collections division of the Michigan State University Library (MSU) was to establish a direction for the comic book section of the popular culture collection, and to state the holdings in the chosen area. The comics chosen as the target collection were the superhero comics of the 1960's through 1975, as this was…

  13. Subject Index to Databases Available from Computer Search Service.

    Science.gov (United States)

    Atkinson, Steven D., Comp.; Knee, Michael, Comp.

    The University Libraries Computer Search Service (State University of New York at Albany, SUNYA) provides access to databases from many vendors including BRS, Dialog, Wilsonline, CA Search, and Westlaw. Members of the Computer Search Service, Collection Development, and Reference Service staffs select vendor services and new databases for their…

  14. Page 1 Subject Index Xi Molecular structure Study of microwave ...

    Indian Academy of Sciences (India)

    controlled atmosphere 3. Potassium hexacyanoferrate. Interaction of potassium hexacyano- ferrate (II) with histidine 199. Potentiometric determination. Potentiometric determination of ther- modynamic parameters for the com- plex formation of Arsenazo I and. Spadins with ytterium (III), zirco- nium (IV) and cerium (IV) 531.

  15. Subject Index S¯adhan¯a Vol. 37, 2012

    Indian Academy of Sciences (India)

    Damage tolerant evaluation of cracked stiffened panels under fatigue loading. 171. De-bond growth. Fatigue de-bond growth in adhesively bonded single lap joints. 79. Decentralized controller. A set of decentralized PID controllers for an n - link robot manipulator. 405. DeConverter. Punjabi to UNL enconversion system.

  16. Page 1 Subject Index Large amplitude Effects of transverse shear ...

    Indian Academy of Sciences (India)

    Effects of transverse shear and rotatory inertia on large amplitude vibration of composite plates and shells 367. Loss of coolant accident. Safety of nuclear power plants 263. Markov chains. Computer-aided reliability analysis of fault- tolerant systems 209. Metal matrix composites. Recent research and development, future ...

  17. ASCUS Directory of Membership and Subject Field Index, 1980.

    Science.gov (United States)

    Association for School, College, and University Staffing, Madison, WI.

    The membership of the Association for School, College, and University Staffing (ASCUS) includes representatives of major educational institutions that prepare personnel for positions in schools, colleges, universities, school districts, and other educational agencies. This directory provides listings of those people on college campuses who are…

  18. Subject Index S¯adhan¯a Vol. 36, 2011

    Indian Academy of Sciences (India)

    for determining cutting force model in turning hardened AISI H11 hot work tool steel 109. Allophone. Salient phonetic features of Indian languages in speech technology. 587. Aluminum alloy 5083. An investigation of the microstructures and properties of metal inert gas and friction stir welds in aluminum alloy 5083. 505.

  19. S¯adhan¯a Vol. 28, 2003 Subject Index

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    review of diamond-cutting glasses. 945. Bulk material glass. Bulk metallic glasses: A new class of engi- neering materials. 783. Carbon doping. Superconductivity in MgB2:Phonon modes and influence of carbon doping. 263. Carbon equilvant. Influence of alloying on hydrogen-assisted cracking and diffusable hydrogen ...

  20. S¯adhan¯a Vol. 34, 2009 Subject Index

    Indian Academy of Sciences (India)

    Gas turbine. Entropy generation in a channel resembling gas turbine cooling passage: Effect of rota- tion number and density ratio on entropy generation. 439 ... Hot filament CVD. High vacuum tribology of polycrystalline dia- mond coatings. 811. Hotwire CVD. Bio-functionalization of silicon nitride-based piezo-resistive ...

  1. S¯adhan¯a Vol. 27, 2002 Subject Index

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    Extra Deep drawn steel sheets. Experimental and finite element analysis of fracture criterion in general yielding fracture mechanics. 631. Fast breeder ... Modelling and control of broad band traf- fic using multiplative multifractual cascades. 699. Human computer interaction. Indian accent text-to-speech system for web.

  2. S¯adhan¯a Vol. 32, 2007 Subject Index

    Indian Academy of Sciences (India)

    Influence of various acids on the physico- mechanical properties of pozzolanic mortars. 683. Prediction scenarios. Prediction of traffic fatalities and prospects for mobility becoming sustainable-safe. 365. Pressure-sensitive paint. Resection methodology for PSP data processing: Recent experiences in NAL 19. Public health.

  3. S¯adhan¯a Vol. 29, 2004 Subject Index

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    Abutments. Velocity and turbulence at a wing-wall abut- ment. 35. Acoustic noise. Application of holography in jet acoustic studies. 389. Air-fuel combustion. Numerical study of effect of oxygen fraction on local entropy generation in a methane-air burner. 641. All solid-state exciter. A compact spark pre-ionized pulser ...

  4. Energy Data Base: Subject Thesaurus

    Energy Technology Data Exchange (ETDEWEB)

    Raridon, M.H. (ed.)

    1987-09-01

    This seventh edition of the subject thesaurus contains the standard vocabulary of indexing terms (descriptors) developed and structured by the technical staff of the Office of Scientific and Technical Information as part of its subject indexing activities for building and maintaining the Energy Data Base (EDB) and other energy information data bases for the Department of Energy (DOE). The purpose of this thesaurus is to enhance the efficiency of information retrieval from these data bases. This structured vocabulary reflects the scope of DOE's research, development, and technological programs and encompasses terminology derived not only from the basic sciences for also from areas of energy resources, conservation, safety, environmental impact, and regulation. There are 21,080 valid descriptors and 5683 forbidden terms in this edition of the Thesaurus. These descriptors are listed alphabetically.

  5. [Differences in Measured Values among Homogenous Assay Reagents of LDL-C in LP-X Positive Serum Samples].

    Science.gov (United States)

    Abe, Misako; Kurosawa, Hideo; Sato, Ryo; Ito, Kumie; Tomono, Yoshiharu; Manita, Daisuke; Hirowatari, Yuji; Yoshida, Hiroshi

    2015-03-01

    The LDL-C level measures with homogeneous (direct) assays in almost of clinical laboratories. Several reports however showed differences in measured values among the assay reagents. We investigated the differences in LDL-C values among direct assays and Friedewald formula (F-f) in 58 LP-X positive serum samples from jaundice patients by comparing LDL-C values measured by anion-exchange chromatography (AEX-HPLC), largely comparable to ultracentrifugation method. Changes in LDL-C values during the treatment of 8 patients were also investigated. Direct assay reagents from Sekisui Medical (S-r), Denka-Seiken (D-r), Wako Chemical (W-r), and Kyowa Medics (K-r) were used for comparison. F-f, S-r, and D-r correlated with AEX-HPLC with r values 0.6. Two samples in which F-f values provided 500 mg/dL plus bias to AEX-HPLC (LDL-C value of 220 mg/dL) demonstrated increased levels of IDL-C before treatment. LDL-C values (S-r and D-r) of the 2 samples were relatively high and near to F-f data while LDL-C values (W-r and K-r) were relatively low and close to AEX-HPLC data. The jaundice treatment decreased LDL-C values (S-r and D-r) and converged to 220 mg/dL, indicating that S-r and D-r might react markedly to IDL. These changes were consistent with decreases in serum free cholesterol and phospholipid in support of LP-X. By contrast, W-r and K-r data showed upward tendency and also converged to 220 mg/dL. These results suggest that LDL-C direct assay reagents would be classified into 2 groups with respect to the reagent reactivity to LP-X.

  6. Electromyographic and neuromuscular variables in unstable postpolio subjects, stable postpolio subjects, and control subjects.

    Science.gov (United States)

    Rodriquez, A A; Agre, J C; Franke, T M

    1997-09-01

    To compare strength and endurance variables obtained in the quadriceps muscles of postpolio and control subjects over a 7-year interval with macro and single fiber electromyography (EMG) variables. A controlled inception cohort study. Neuromuscular research laboratory of a university hospital. A cohort of 23 postpolio and 14 control subjects. All postpolio subjects had a history, physical examination, and EMG consistent with previous poliomyelitis, and had greater than antigravity strength in the quadriceps muscle tested. Unstable postpolio subjects acknowledged new quadriceps weakness over the 7-year period of the study (n = 11), and stable postpolio subjects denied new weakness of the quadriceps over the same period (n = 12). All subjects had tests of neuromuscular function of the quadriceps muscles at the onset of this study and yearly over a 7-year period. EMG variables were determined on a separate day after the seventh year of neuromuscular measurements. Neuromuscular variables measured were isometric knee extension peak torque, isometric endurance (time to inability to maintain knee extensor contraction at 40% of maximal torque), tension time index (TTI) (product of isometric endurance time and 40% of maximal torque), and recovery of torque at 10 minutes after the endurance test. EMG variables were macro EMG and single fiber EMG (jitter, fiber density, and percent blocking). Unstable postpolio subjects did not lose strength more rapidly than stable postpolio subjects or control subjects. Unstable postpolio subjects were significantly weaker, had decreased TTI, larger macro EMG amplitude, greater jitter, blocking, and fiber density in comparison with stable postpolio subjects (all p postpolio group (p .05) with neuromuscular or EMG variables in control, stable, or unstable postpolio subjects.

  7. An lp-norm approach to robust probabilistic inspection of plate-like structure defects with guided waves

    Science.gov (United States)

    Li, Dan; Yu, Hao; Xu, Feng; Liu, Da Peng; Qiu Zhang, Jian; Ta, De an

    2017-10-01

    In this paper, an lp-norm approach to robust probabilistic inspection of plate-like structure defects with guided waves is proposed. Analytical results show that the more the outliers in the measurements, the smaller p is preferred. Moreover, the relationship between our and the conventional signal difference coefficient (SDC) is also provided. While the experimental results verify the analytical ones, it is also shown that our approach has a good tolerance for impulsive noise interference, namely the unexpected artifacts in the reconstructed tomographic image caused by the impulsive interference are eliminated.

  8. Listening to people to cure people: the LpCp - tool, an instrument to evaluate hospital humanization.

    Science.gov (United States)

    Buffoli, M; Bellini, E; Bellagarda, A; Di Noia, M; Nickolova, M; Capolongo, S

    2014-01-01

    In the healthcare environment, nowadays, only a few among the available evaluation systems pay enough attention to certain social sustainability aspects. Among these, humanization plays a key role in an environment, like hospitals, where the mental and physical well-being of patients and healthcare operators is crucial. Our research project, known as 'SustHealth', is focused on the deficiencies of the evaluation methodology and aims at developing an assessment system related to a questionnaire-based investigation capable of revealing the most influential conditions and dynamics in people's hospital experience, while also recommending areas in hospitals where efforts can be made to sustain improvement strategies. The humanization of healthcare structures began with a significant investigation to assess all the major evaluation tools in both hospitals - to better understand the physical and emotional interactions in the structure-user ratio - and other areas. This helped understand the strengths and criticalities of the systems that were examined. This first step also allowed to shed light on the most important aspects to keep in mind when developing an evaluation system. During the operational steps an all-new LpCp - tool (Listening to people to Cure people) was created, which includes a questionnaire-based investigation and processing software, and its application for beta-testing in a 600-bed hospital in Milan. The LpCp - tool proved to be effective and capable of finding the deficiencies and potential in the examined hospital. Considering different themes through alternative viewpoints (staff, patients/visitors, technicians, etc.), the tool has allowed underlining different perceptions of the same place and also provided sound information to guide healthcare management in taking informed decisions about specific problems or users. Former interesting results show an inadequate appraisal about e.g. on-site facilities or recreational activities and a lack of

  9. Predicción del consumo de electricidad y gas lp en un hotel mediante redes neuronales artificiales.

    OpenAIRE

    Montero Laurencio, Reineris; PÉREZ TELLO, CARLOS; Góngora Leyva, Ever

    2011-01-01

    El presente trabajo se desarrollo con el fin de aportar a la mejora de las herramientas actuales de planificación energética aplicada a hoteles turísticos. Con ellos es posible predecir el consumo de energía eléctrica y de gas LP de una instalación con mas de un noventa por ciento de precisión, empleando redes neurales artificiales (RNA) como modelos de ajuste y predictivos. Como variables de entrada a las estructuras de los modelos se tuvieron en cuenta las condiciones climatológicas de la r...

  10. Air University Library Index to Military Periodicals. Cumulative Issue January - December 1988. Volume 39, Number 4

    National Research Council Canada - National Science Library

    Adams, Emily

    1988-01-01

    The Air University Library Index to Military Periodicals is a subject index to significant articles, news items, and editorials appearing in 77 English language military and aeronautical periodicals...

  11. Air University Library Index to Military Periodicals. Cumulative Issue January - December 1985. Volume 36, Number 4

    National Research Council Canada - National Science Library

    Goodman, A

    1985-01-01

    The Air University Library Index to Military Periodicals is a subject index to significant articles, news items, and editorials appearing in 76 English language military and aeronautical periodicals...

  12. An extracellular matrix response element in the promoter of the LpS1 genes of the sea urchin Lytechinus pictus.

    Science.gov (United States)

    Seid, C A; Ramachandran, R K; George, J M; Govindarajan, V; González-Rimbau, M F; Flytzanis, C N; Tomlinson, C R

    1997-08-01

    The extracellular matrix (ECM) has been shown to play an important role in development and tissue-specific gene expression, yet the mechanism by which genes receive signals from the ECM is poorly understood. The aboral ectoderm-specific LpS1-alpha and -beta genes of Lytechinus pictus , members of the Spec gene family, provide an excellent model system to study ECM- mediated gene regulation. Disruption of the ECM by preventing collagen deposition using the lathrytic agent beta-aminopropionitrile (BAPN) inhibits LpS1 gene transcription. LpS1 transcription resumes after removal of BAPN and subsequent collagen reformation. Using a chloramphenicol acetyltransferase (CAT) reporter gene assay, we show that a 125 bp region of the LpS1-beta promoter from -108 to +17 contains an ECM response element (ECM RE). Insertion of the 125 bp region into the promoter of the metallothionein gene of L. pictus, a gene unaffected by ECM disruption, caused the fused promoter to become ECM dependent. As with the endogenous LpS1 genes, CAT activity directed by the fused LpS1-beta promoter resumed in embryos recovered from ECM disruption. A mutation in a cis -acting element called the proximal G-string, which lies in the 125 bp region, caused CAT activity levels in ECM-disrupted embryos to equal that of the wild-type LpS1-bet apromoter in ECM-intact embryos. These results suggest that the intact ECM normally transmits signals to inhibit repressor activity at the proximal G-string in aboral ectoderm cells. Consistent with these results were our findings which showed that in addition to expression in the aboral ectoderm, the proximal G-string mutation caused expression of the CAT gene in oral ectoderm cells. These studies suggested that the proximal G-string serves as a binding site for negative regulation of the LpS1 genes in oral ectoderm during development. We also examined trans -acting factors binding the proximal G-string following ECM disruption. Band shift gels revealed a predominant

  13. Lp-PLA2 silencing protects against ox-LDL-induced oxidative stress and cell apoptosis via Akt/mTOR signaling pathway in human THP1 macrophages.

    Science.gov (United States)

    Zheng, HuaDong; Cui, DaJiang; Quan, XiaoJuan; Yang, WeiLin; Li, YingNa; Zhang, Lin; Liu, EnQi

    2016-09-02

    Atherosclerosis is a disease of the large- and medium-size arteries that is characterized by the formation of atherosclerotic plaques, in which foam cells are the characteristic pathological cells. However, the key underlying pathomechanisms are still not fully elucidated. In this study, we investigated the role of lipoprotein-associated phospholipase A2 (Lp-PLA2) in ox-LDL-induced oxidative stress and cell apoptosis, and further, elucidated the potential machanisms in human THP1 macrophages. Flow cytometry and western blot analyses showed that both cell apoptosis and Lp-PLA2 expression were dose-dependently elevated after ox-LDL treatment for 24 h and also time-dependently increased after 50 mg/L ox-LDL incubation in THP1 macrophages. In addition, Lp-PLA2 silencing decreased ox-LDL-induced Lp-PLA2 and CD36 expression in THP1 macrophages. We also found that the levels of oil red O-staining, triglyceride (TG) and total cholesterol (TC) were significantly upregulated in ox-LDL-treated THP1 cells, but inhibited by Lp-PLA2 silencing. Furthermore, ox-LDL treatment resulted in significant increases of ROS and MDA but a marked decrease of SOD, effects that were reversed by Lp-PLA2 silencing in THP1 cells. Lp-PLA2 silencing reduced ox-LDL-induced cell apoptosis and caspase-3 expression in THP1 cells. Moreover, Lp-PLA2 siRNA transfection dramatically lowered the elevated levels of p-Akt and p-mTOR proteins in ox-LDL-treated THP1 cells. Both PI3K inhibitor LY294002 and mTOR inhibitor rapamycin decreased the augmented caspase-3 expression and TC content induced by ox-LDL, respectively. Taken together, these results revealed that Lp-PLA2 silencing protected against ox-LDL-induced oxidative stress and cell apoptosis via Akt/mTOR signaling pathway in human THP1 macrophages. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. 76 FR 25229 - Special Conditions: Gulfstream Aerospace LP (GALP) Model G250 Airplane, Dynamic Test Requirements...

    Science.gov (United States)

    2011-05-04

    ... Trauma Index (TTI) and lateral pelvic acceleration, which were in addition to the existing injury... arm, chest, and head of an occupant seated next to the structure. A conservative representation of the... padding (foam or equivalent) such as Ensolite. (c) Thoracic Trauma: TTI injury criterion must be...

  15. EJSCREEN Indexes 2016 Public

    Data.gov (United States)

    U.S. Environmental Protection Agency — There is an EJ Index for each environmental indicator. There are eleven EJ Indexes in EJSCREEN reflecting the 11 environmental indicators. The EJ Index names are:...

  16. EJSCREEN Indexes 2015 Public

    Data.gov (United States)

    U.S. Environmental Protection Agency — There is an EJ Index for each environmental indicator. There are eight EJ Indexes in EJSCREEN reflecting the 8 environmental indicators. The EJ Index names are:...

  17. Effects of chlorpyrifos and chlorantraniliprole on fermentation quality of alfalfa (Medicago sativa L.) silage inoculated with or without Lactobacillus plantarum LP.

    Science.gov (United States)

    Zhang, Qing; Yu, Zhu; Wang, Xianguo; Na, Risu

    2017-03-01

    The effects of pesticides and Lactobacillus plantarum (LP) on fermentation quality of alfalfa (Medicago sativa L.) silage were investigated. Chlorpyrifos and chlorantraniliprole were sprayed on the surface of alfalfa plants at 658.6 and 45.0 g active ingredient/ha, respectively. Alfalfa plants were harvested on day 5 post-application and ensiled with or without LP. Chlorpyrifos and chlorantraniliprole decreased the yeast count of alfalfa material (P < 0.05). Both pesticides increased the butyric acid content of alfalfa silage (P < 0.001). Chlorpyrifos increased pH and decreased lactic acid, acetic acid and short-chain fatty acid contents (P < 0.05). LP decreased pH and butyric acid content, and increased lactic acid and short-chain fatty acid contents of alfalfa silage treated with pesticides (P < 0.05). LP increased the concentration of chlorpyrifos residue in alfalfa silage (P < 0.05). Chlorpyrifos and chlorantraniliprole affected the microbial communities of the material before ensiling, especially coliform bacteria and yeast; the two pesticide residues were reduced after the fermentation of alfalfa silage and affected the fermentation process, whereas LP improved the fermentation quality of pesticides-contaminated alfalfa silage and slowed down the dissipation of chlorpyrifos. © 2016 Japanese Society of Animal Science.

  18. VizieR Online Data Catalog: 2yrs of eclipse data & precise RVs for LP661-13 (Dittmann+, 2017)

    Science.gov (United States)

    Dittmann, J. A.; Irwin, J. M.; Charbonneau, D.; Berta-Thompson, Z. K.; Newton, E. R.; Latham, D. W.; Latham, C. A.; Esquerdo, G.; Berlind, P.; Calkins, M. L.

    2017-09-01

    MEarth-south, like its northern counterpart, consists of eight f/9 40cm Ritchey-Chretien telescopes on German equatorial mounts. The telescopes are located at the Cerro-Tololo International Observatory (CTIO) in Chile. The telescopes are automated and take data on every clear night. We obtained RV measurements with the Tillinghast Reflector Echelle Spectrograph (TRES) on the 1.5m Tillinghast reflector located at the Fred Lawrence Whipple Observatory (FLWO) on Mt. Hopkins, Arizona (R=44000). We obtained 14 observations of LP 661-13 with TRES, with eight exposures taken in the 2014 observing season (2014 February 18-2014 March 28) and six taken in the 2015 observing season (2014 December 27-2015 January 06). Follow-up photometric observations of both primary and secondary eclipses were performed with the MEarth-south telescopes. We observed 11 unique eclipse events with six different telescopes. We have obtained 9173 individual observations of LP 661-13, with 5098 observations being in-eclipse measurements and 4075 out-of-eclipse measurements. (2 data files).

  19. Nucleic acid indexing

    Science.gov (United States)

    Guilfoyle, Richard A.; Guo, Zhen

    1999-01-01

    A restriction site indexing method for selectively amplifying any fragment generated by a Class II restriction enzyme includes adaptors specific to fragment ends containing adaptor indexing sequences complementary to fragment indexing sequences near the termini of fragments generated by Class II enzyme cleavage. A method for combinatorial indexing facilitates amplification of restriction fragments whose sequence is not known.

  20. Indexing executive compensation contracts

    NARCIS (Netherlands)

    Dittmann, I.; Maug, E.; Spalt, O.G.

    2013-01-01

    We analyze the efficiency of indexing executive pay by calibrating the standard compensation model to a large sample of U.S. CEOs. The benefits from indexing the strike price of options are small, and fully indexing all options would increase compensation costs by 50% for most firms. Indexing has

  1. Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism

    Energy Technology Data Exchange (ETDEWEB)

    Bakolitsa, Constantina; Kumar, Abhinav; Carlton, Dennis; Miller, Mitchell D.; Krishna, S.Sri; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L.; Chiu, Hsiu-Ju; Clayton, Thomas; Deller, Marc C.; Duan, Lian; Elsliger, Marc-André; Feuerhelm, Julie; Grzechnik, Slawomir K.; Grant, Joanna C.; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Kozbial, Piotr; Marciano, David; McMullan, Daniel; Morse, Andrew T.; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Paulsen, Jessica; Reyes, Ron; Rife, Christopher L.; Tien, Henry J.; Trout, Christina V.; van den Bedem, Henry; Weekes, Dana; Xu, Qingping; Hodgson, Keith O.; Wooley, John; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A. (Burnham)

    2011-08-17

    The structure of LP2179, a member of the PF08866 (DUF1831) family, suggests a novel {alpha} + {beta} fold comprising two {beta}-sheets packed against a single helix. A remote structural similarity to two other uncharacterized protein families specific to the Bacillus genus (PF08868 and PF08968), as well as to prokaryotic S-adenosylmethionine decarboxylases, is consistent with a role in amino-acid metabolism. Genomic neighborhood analysis of LP2179 supports this functional assignment, which might also then be extended to PF08868 and PF08968.

  2. Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism.

    Science.gov (United States)

    Bakolitsa, Constantina; Kumar, Abhinav; Carlton, Dennis; Miller, Mitchell D; Krishna, S Sri; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L; Chiu, Hsiu Ju; Clayton, Thomas; Deller, Marc C; Duan, Lian; Elsliger, Marc André; Feuerhelm, Julie; Grzechnik, Slawomir K; Grant, Joanna C; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K; Klock, Heath E; Knuth, Mark W; Kozbial, Piotr; Marciano, David; McMullan, Daniel; Morse, Andrew T; Nigoghossian, Edward; Okach, Linda; Oommachen, Silvya; Paulsen, Jessica; Reyes, Ron; Rife, Christopher L; Tien, Henry J; Trout, Christina V; van den Bedem, Henry; Weekes, Dana; Xu, Qingping; Hodgson, Keith O; Wooley, John; Deacon, Ashley M; Godzik, Adam; Lesley, Scott A; Wilson, Ian A

    2010-10-01

    The structure of LP2179, a member of the PF08866 (DUF1831) family, suggests a novel α+β fold comprising two β-sheets packed against a single helix. A remote structural similarity to two other uncharacterized protein families specific to the Bacillus genus (PF08868 and PF08968), as well as to prokaryotic S-adenosylmethionine decarboxylases, is consistent with a role in amino-acid metabolism. Genomic neighborhood analysis of LP2179 supports this functional assignment, which might also then be extended to PF08868 and PF08968.

  3. Lp Lp Lp-mixed intersection bodies and star duality

    Indian Academy of Sciences (India)

    Author Affiliations. Zhao Chang-jian1 Wing-Sum Cheung2. Department of Information and Mathematics Sciences, College of Science, China Jiliang University, Hangzhou 310018, People's Republic of China; Department of Mathematics, The University of Hong Kong, Pokfulam Road, Hong Kong ...

  4. CLASSIFIED BY SUBJECT IN SPORT SCIENCES

    Directory of Open Access Journals (Sweden)

    Petar Protić

    2007-05-01

    Full Text Available High school and academic libraries users need precise classifi cation and subject access review of printed and electronic resources. In library catalogue since, Universal Decimal Classifi cation (UDC -similar to Dewey system - ex classifi es research and scientifi c areas. in subject areas of 796 Sport and 371 Teaching. Nowadays, users need structure of subjects by disciplines in science. Full-open resources of library must be set for users in subject access catalogue, because on the example of bachelors degree thesis in Faculty of Physical Education in Novi Sad they reaches for disciplines in database with 36 indexes sort by fi rst letters in names (Athletics, Boxing, Cycling, etc. This database have single and multiplied index for each thesis. Users in 80% cases of research according to the subject access catalogue of this library.

  5. Primary Index Term Secondary Index Term Tertiary Index term ...

    Indian Academy of Sciences (India)

    chaubey

    Tertiary Index term. Geosciences. Solid earth. Tectonics. Structural Geology. Geodynamics. Seismology. Exploration geophysics. Seismic hazards. Geomagnetism. Mineralogy. Petrology. Metamorphic. Igneous. Sedimentary. Fossil fuels. Petroleum and coal. Isotope geology. Geochronology. Isotope geology. Landform and.

  6. WA Smith: LP Vosloo, CH van Niekerkand FP Theron Gossypol, a ...

    African Journals Online (AJOL)

    and compared for volume, colour, motility, concentration, viability, morphology, viability after deep freezing and swimming speed after deep freezing. The more subjective methods of semen evaluation were included in the study because of their importance in practical semen evaluation. Semen colour as a possible indicator ...

  7. Sensibility and Subjectivity: Levinas’ Traumatic Subject

    Directory of Open Access Journals (Sweden)

    Rashmika Pandya

    2011-02-01

    Full Text Available The importance of Levinas’ notions of sensibility and subjectivity are evident in the revision of phenomenological method by current phenomenologists such as Jean-Luc Marion and Michel Henry. The criticisms of key tenants of classical phenomenology, intentionality and reduction, are of a particular note. However, there are problems with Levinas’ characterization of subjectivity as essentially sensible. In “Totality and Infinity” and “Otherwise than Being”, Levinas criticizes and recasts a traditional notion of subjectivity, particularly the notion of the subject as the first and foremost rational subject. The subject in Levinas’ works is characterized more by its sensibility and affectedness than by its capacity to reason or affect its world. Levinas ties rationality to economy and suggests an alternative notion of reason that leads to his analysis of the ethical relation as the face-to-face encounter. The ‘origin’ of the social relation is located not in our capacity to know but rather in a sensibility that is diametrically opposed to the reason understood as economy. I argue that the opposition in Levinas’ thought between reason and sensibility is problematic and essentially leads to a self-conflicted subject. In fact, it would seem that violence characterizes the subject’s self-relation and, thus, is also inscribed at the base of the social relation. Rather than overcoming a problematic tendency to dualistic thought in philosophy Levinas merely reverses traditional hierarchies of reason/emotion, subject/object and self/other. 

  8. Analysis in indexing

    DEFF Research Database (Denmark)

    Mai, Jens Erik

    2005-01-01

    The paper discusses the notion of steps in indexing and reveals that the document-centered approach to indexing is prevalent and argues that the document-centered approach is problematic because it blocks out context-dependent factors in the indexing process. A domain-centered approach to indexing...... is presented as an alternative and the paper discusses how this approach includes a broader range of analyses and how it requires a new set of actions from using this approach; analysis of the domain, users and indexers. The paper concludes that the two-step procedure to indexing is insufficient to explain...... the indexing process and suggests that the domain-centered approach offers a guide for indexers that can help them manage the complexity of indexing....

  9. Sparse Adaptive Iteratively-Weighted Thresholding Algorithm (SAITA) for Lp-Regularization Using the Multiple Sub-Dictionary Representation.

    Science.gov (United States)

    Li, Yunyi; Zhang, Jie; Fan, Shangang; Yang, Jie; Xiong, Jian; Cheng, Xiefeng; Sari, Hikmet; Adachi, Fumiyuki; Gui, Guan

    2017-12-15

    Both L 1/2 and L 2/3 are two typical non-convex regularizations of L p (0dictionary sparse transform strategies for the two typical cases p∈{1/2, 2/3} based on an iterative Lp thresholding algorithm and then proposes a sparse adaptive iterative-weighted L p thresholding algorithm (SAITA). Moreover, a simple yet effective regularization parameter is proposed to weight each sub-dictionary-based L p regularizer. Simulation results have shown that the proposed SAITA not only performs better than the corresponding L₁ algorithms but can also obtain a better recovery performance and achieve faster convergence than the conventional single-dictionary sparse transform-based L p case. Moreover, we conduct some applications about sparse image recovery and obtain good results by comparison with relative work.

  10. Approximation of signals (functions belonging to the weighted W(Lp,ξ(t-class by linear operators

    Directory of Open Access Journals (Sweden)

    M. L. Mittal

    2006-01-01

    Full Text Available Mittal and Rhoades (1999–2001 and Mittal et al. (2006 have initiated the studies of error estimates En(f through trigonometric Fourier approximations (TFA for the situations in which the summability matrix T does not have monotone rows. In this paper, we determine the degree of approximation of a function f˜, conjugate to a periodic function f belonging to the weighted W(Lp,ξ(t-class (p≥1, where ξ(t is nonnegative and increasing function of t by matrix operators T (without monotone rows on a conjugate series of Fourier series associated with f. Our theorem extends a recent result of Mittal et al. (2005 and a theorem of Lal and Nigam (2001 on general matrix summability. Our theorem also generalizes the results of Mittal, Singh, and Mishra (2005 and Qureshi (1981-1982 for Nörlund (Np-matrices.

  11. Mejor lp-aproximación y fórmulas de reparto del excedente en funciones financieras supraditivas

    Directory of Open Access Journals (Sweden)

    Quesada, J.M.

    1999-01-01

    Full Text Available El objetivo de este trabajo es caracterizar los diferentes tipos de reparto del capital obtenido por la inversión conjunta de n cantidades, c1, c2,..., cn aportadas por n inversores distintos. Este problema tiene especial interés en el caso de que las funciones financieras sean supraditivas. Tales modelos de reparto surgen como casos particulares de un mismo problema de mejor aproximación en lp,1 <= p <= INF, sobre un conjunto convexo y cerrado. Asimismo estudiamos las propiedades que caracterizan a una función de reparto y concluimos, finalmente, que la única formula de reparto que satisface estas propiedades y además es independiente de la ley financiera es la del reparto proporcional del capital obtenido en función de las cantidades invertidas.

  12. Quantum Mechanics and Molecular Mechanics Study of the Catalytic Mechanism of Human AMSH-LP Domain Deubiquitinating Enzymes.

    Science.gov (United States)

    Zhu, Wenyou; Liu, Yongjun; Ling, Baoping

    2015-08-25

    Deubiquitinating enzymes (DUBs) catalyze the cleavage of the isopeptide bond in polyubiquitin chains to control and regulate the deubiquitination process in all known eukaryotic cells. The human AMSH-LP DUB domain specifically cleaves the isopeptide bonds in the Lys63-linked polyubiquitin chains. In this article, the catalytic mechanism of AMSH-LP has been studied using a combined quantum mechanics and molecular mechanics method. Two possible hydrolysis processes (Path 1 and Path 2) have been considered. Our calculation results reveal that the activation of Zn(2+)-coordinated water molecule is the essential step for the hydrolysis of isopeptide bond. In Path 1, the generated hydroxyl first attacks the carbonyl group of Gly76, and then the amino group of Lys63 is protonated, which is calculated to be the rate limiting step with an energy barrier of 13.1 kcal/mol. The energy barrier of the rate limiting step and the structures of intermediate and product are in agreement with the experimental results. In Path 2, the protonation of amino group of Lys63 is prior to the nucleophilic attack of activated hydroxyl. The two proton transfer processes in Path 2 correspond to comparable overall barriers (33.4 and 36.1 kcal/mol), which are very high for an enzymatic reaction. Thus, Path 2 can be ruled out. During the reaction, Glu292 acts as a proton transfer mediator, and Ser357 mainly plays a role in stabilizing the negative charge of Gly76. Besides acting as a Lewis acid, Zn(2+) also influences the reaction by coordinating to the reaction substrates (W1 and Gly76).

  13. CENDI Indexing Workshop

    Science.gov (United States)

    1994-01-01

    The CENDI Indexing Workshop held at NASA Headquarters, Two Independence Square, 300 E Street, Washington, DC, on September 21-22, 1994 focused on the following topics: machine aided indexing, indexing quality, an indexing pilot project, the MedIndEx Prototype, Department of Energy/Office of Scientific and Technical Information indexing activities, high-tech coding structures, category indexing schemes, and the Government Information Locator Service. This publication consists mostly of viewgraphs related to the above noted topics. In an appendix is a description of the Government Information Locator Service.

  14. Regulatory and technical reports (abstract index journal): Annual compilation for 1994. Volume 19, Number 4

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-01

    This compilation consists of bibliographic data and abstracts for the formal regulatory and technical reports issued by the US Nuclear Regulatory Commission (NRC) Staff and its contractors. It is NRC`s intention to publish this compilation quarterly and to cumulate it annually. The main citations and abstracts in this compilation are listed in NUREG number order. These precede the following indexes: secondary report number index, personal author index, subject index, NRC originating organization index (staff reports), NRC originating organization index (international agreements), NRC contract sponsor index (contractor reports), contractor index, international organization index, and licensed facility index. A detailed explanation of the entries precedes each index.

  15. 76 FR 55720 - BB&T Capital Partners Mezzanine Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the...

    Science.gov (United States)

    2011-09-08

    ... ADMINISTRATION BB&T Capital Partners Mezzanine Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that BB&T Capital Partners... Regulations (13 CFR 107.730). BB&T Capital Partners Mezzanine Fund II proposes to provide debt security...

  16. Rapid Response to a College Outbreak of Meningococcal Serogroup B Disease: Nation's First Widespread Use of Bivalent rLP2086 Vaccine

    Science.gov (United States)

    Fiorito, Theresa M.; Bornschein, Suzanne; Mihalakos, Alysia; Kelleher, Catherine M.; Alexander-Scott, Nicole; Kanadanian, Koren V.; Raymond, Patricia; Sicard, Kenneth; Dennehy, Penelope H.

    2017-01-01

    Objective: To outline the reasoning behind use of bivalent rLP2086 in a Rhode Island college meningococcal B disease outbreak, highlighting the timeline from outbreak declaration to vaccination clinic, emphasizing that these two time points are vaccination.…

  17. L.P. Sabaneev’s journals: history of hunting journals, collection of work "Nature", "Journal of Hunting", journal "Nature and Hunting"

    Directory of Open Access Journals (Sweden)

    Kubyshko Olga Vladimirovna

    2016-03-01

    Full Text Available The article presents the historical and typological analysis of the heritage of the outstanding scientist, publisher and editor L.P. Sabaneev - «Nature», «Hunting» and «Nature and Hunting» journals as an example of the formation and development of hunting journals of the XIX century. Orientation to the works by the famous biologist, scientist, publisher and editor L.P. Sabaneev seems quite relevant, due to his modern outlook on nature, and actual continuation of his work - the publication of high- quality scientific and popular and specialized magazines with a clear moral and patriotic position, which focuses on environmental and hunting issues. The paper attempts to trace the chronological changes in the typological picture of publications issued by L.P. Sabaneev, and pays attention to strengthening the typological features of mass publications and information component, focuses on the creation of the most successful models of specialized hunting publication - magazine «Nature and Hunting». By all evidence, L.P. Sabaneev tended to reach the widest possible audience with a view to promote and popularize environmental awareness system of views on hunting and wildlife management.

  18. Rapid Response to a College Outbreak of Meningococcal Serogroup B Disease: Nation's First Widespread Use of Bivalent rLP2086 Vaccine

    Science.gov (United States)

    Fiorito, Theresa M.; Bornschein, Suzanne; Mihalakos, Alysia; Kelleher, Catherine M.; Alexander-Scott, Nicole; Kanadanian, Koren V.; Raymond, Patricia; Sicard, Kenneth; Dennehy, Penelope H.

    2017-01-01

    Objective: To outline the reasoning behind use of bivalent rLP2086 in a Rhode Island college meningococcal B disease outbreak, highlighting the timeline from outbreak declaration to vaccination clinic, emphasizing that these two time points are <3 days apart. Participants: Staff, faculty, and students at College X eligible for vaccination.…

  19. Implementation of Online Peer Assessment in a Design for Learning and Portfolio (D4L+P) Program to Help Students Complete Science Projects

    Science.gov (United States)

    Wuttisela, Karntarat; Wuttiprom, Sura; Phonchaiya, Sonthi; Saengsuwan, Sayant

    2016-01-01

    Peer assessment was one of the most effective strategies to improve students' understanding, metacognitive skills, and social interaction. An online tool, "Designing for Learning and Portfolio (D4L+P)", was developed solely to support the T5 (tasks, tools, tutorials, topicresources, and teamwork) method of teaching and learning. This…

  20. Systemic administration and local microinjection into the central nervous system of the 5-HT(7) receptor agonist LP-211 modify the sleep-wake cycle in the rat.

    Science.gov (United States)

    Monti, Jaime M; Leopoldo, Marcello; Jantos, Héctor

    2014-02-01

    The effects of LP-211, a selective serotonin 5-HT7 receptor agonist were studied in adult rats implanted for chronic sleep recordings. Intraperitoneal administration of LP-211 (2.5-10mg/kg) during the light phase of the light-dark cycle significantly increased wakefulness (W) and reduced rapid-eye-movement sleep (REMS) and the number of REM periods during the 6-h recording period. Direct infusion of LP-211 into the dorsal raphe nucleus (DRN) (2-6 mM), locus coeruleus nucleus (LC) (4 mM), basal forebrain (horizontal limb of the diagonal band of Broca) (HDB) (2 mM) or laterodorsal tegmental nucleus (LDT) (4 mM) induced also a decrease of REMS. Additionally, microinjection of the 5-HT7 receptor ligand into the HDB (2 mM) augmented W. Presently, there is no satisfactory explanation for the effect of 5-HT7 receptor activation on W and REMS occurrence. Additional studies are required to characterize the neurotransmitter systems responsible for the actions of LP-211 on the behavioral states. Copyright © 2013 Elsevier B.V. All rights reserved.