Sample records for subject area entries



    Groshev A. V.; Shulga A. V.


    Book-entry securities as the subject of theft. The article deals with the questions of legal assessment of crimes, targeted at embezzlement of book-entry securities. The article reports author's position concerning the expediency of creation in Russian criminal law system, the criminal liability for book-entry security taking in articles about theft and property crimes. The plot of the article requires the discussion in terms of recognizing book-entry securities the subject of theft, and crea...

  2. Advanced Restricted Area Entry Control System (ARAECS)


    Appleton, Robert; Casillas, Jose; Scales, Gregory; Green, Robert; Niehoff, Mellissa; Fitzgerald, David; Ouellette, David


    Approved for public release; distribution is unlimited The Navy requires a capability for effective and efficient entry control for restricted areas that house critical assets. This thesis describes an Advanced Restricted Area Entry Control System (ARAECS) to meet this requirement. System requirements were obtained from existing governing documentation as well as stakeholder inputs. A functional architecture was developed and then modeled using the Imagine That Inc. ExtendSim tool. Factors...

  3. Foveal avascular zone area in normal subjects

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    Chang Xu


    Full Text Available AIM: To measure the foveal avascular zone(FAZarea and to investigate the characteristics of the FAZ area in normal eyes, using optical coherence tomography(OCTangiography.METHODS: This was a cross-sectional study. The FAZ area was measured in 69 participants, for a total of 138 eyes, using RTVue-100 OCT. The relations between the FAZ area and the potential factors were evaluated by univariate and multivariate linear regression analysis. Differences between the right and left eyes were calculated, and values were compared by means of a paired t test. Pearson correlation analysis was performed to assess the relationships of the FAZ area between the right and left eyes. RESULTS: The mean FAZ area was 0.30±0.11mm2 in all subjects. For the male subjects, the mean FAZ area was 0.29±0.13mm2, and for the female subjects 0.31±0.09mm2, with no significant difference(t=-1.346,P=0.180. The FAZ area did not correlate with all the potential factors. The mean FAZ area in the right eye was 0.30±0.11mm2, and in the left eye was 0.30±0.10mm2,with no significant difference(P=0.943. There was a strong correlation between the right and left eyes for the FAZ area. CONCLUSION: OCT angiography is a noninvasive method of visualizing and measuring the FAZ area in normal subjects. The FAZ area does not correlate with old age, sex and other factors. It shows significant interocular symmetry in normal subjects.

  4. 32 CFR 552.25 - Entry regulations for certain Army training areas in Hawaii. (United States)


    ... in Hawaii. 552.25 Section 552.25 National Defense Department of Defense (Continued) DEPARTMENT OF THE... Regulations for Certain Army Training Areas in Hawaii § 552.25 Entry regulations for certain Army training areas in Hawaii. (a) Purpose. (1) This regulation establishes procedures governing the entry onto...

  5. Local Development of Subject Area Item Banks. (United States)

    Ward, Annie W.; Barlow, Gene


    It is feasible for school districts to develop and use subject area tests as reliable as those previously available only from commercial publishers. Three projects in local item development in a large school district are described. The first involved only Algebra 1. The second involved life science and career education at the elementary level; and…

  6. The Structure and Contents of the English Written Entry Examination as a Major Subject at the Department of Linguistics

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    Светлана Евгеньевна Боброва


    Full Text Available The author of the article has been writing English entry examinations for PFUR for over a decade. In this article she analyses the structure and contents of the English language entry examination for prospective students of Linguistics at the Faculty of Philology. The requirements for the entry written test are set by the State standards of complete secondary education for foreign languages at the level of a major subject. The PFUR entry examination has always been written in accordance with recommendations of the Education and Science Ministry and the Federal Institute of Pedagogical Assessment.

  7. Acquisition in different and special subject areas

    CERN Document Server

    Katz, Linda S


    Learn how acquisitions librarians successfully serve specialized users! In this book, you'll find profiles, methods, and processes for acquisitions in specialized subject areas, such as local and regional poetry, oceanography, educational information in electronic formats, popular fiction, regional and ethnic materials, and more. Seasoned acquisitions librarians share their experiences in gathering the hard-to-find materials their libraries' highly specialized clients need to access. You'll also examine issues surrounding the acquisition of new reference tools that are vital in today's emergi

  8. 76 FR 19380 - Notice of Entry Into Effect of MARPOL Annex V Wider Caribbean Region Special Area (United States)


    ... SECURITY Coast Guard Notice of Entry Into Effect of MARPOL Annex V Wider Caribbean Region Special Area... effect of discharge requirements from ships in the Wider Caribbean Region (WCR) special area (SA) as...(b), the Coast Guard announces the May 1, 2011 date for entry into effect of discharge requirements...

  9. Crying in the park: Autism stigma, school entry and maternal subjectivity


    Lilley, Rozanna


    In this article I focus on the experiences of mothers of children diagnosed with autism as they respond to, and are shaped by, encounters with stigmatising practices at primary school entry. Analysing narratives recorded during interviews with 22 mothers of children diagnosed with autism in Sydney, Australia, I argue that Erving Goffman's theorising around 'courtesy stigma' is inadequate to the task of understanding the felt experiences of these women. I propose the notion of 'attachment stig...

  10. Crying in the park: Autism stigma, school entry and maternal subjectivity

    Directory of Open Access Journals (Sweden)

    Rozanna Lilley


    Full Text Available In this article I focus on the experiences of mothers of children diagnosed with autism as they respond to, and are shaped by, encounters with stigmatising practices at primary school entry. Analysing narratives recorded during interviews with 22 mothers of children diagnosed with autism in Sydney, Australia, I argue that Erving Goffman's theorising around 'courtesy stigma' is inadequate to the task of understanding the felt experiences of these women. I propose the notion of 'attachment stigma', which more readily does the double work of referring to both the intersubjective mother/child relationship, often intensified and prolonged due to disability, and the role of mothering ideologies in shaping stigmatising responses. Mothers' school exclusion narratives point to the salience of experiences of stigmatisation in the lives of families of children with autism, and to the continuing force of gendered moral rationalities underpinned by punishing notions of 'good' and 'bad' mothering.

  11. Effect of A-Level Subject Choice and Entry Tariff on Final Degree and Level 1 Performance in Biosciences (United States)

    King, Nicola C.; Aves, Stephen J.


    Following the publication of the higher education white paper increasing entry tariff and widening participation have become even more important issues for universities. This report examines the relationship between entry tariff and undergraduate achievement in Biosciences at the University of Exeter. We show that, whilst there is a significant…

  12. Drilling in areas subject to environmental protection; A perfuracao em area de protecao ambiental

    Energy Technology Data Exchange (ETDEWEB)

    Mendonca, Ricardo Teixeira; Guimaraes, Antimio Santos [PETROBRAS, XX (Brazil). Distrito de Perfuracao do Nordeste. Div. Tecnica; Santana, Manoel Messias de [PETROBRAS, XX (Brazil). Regiao de Producao do Nordeste. Setor de Seguranca Industrial


    This paper presents the practices developed for pollution control in areas subject to environmental protection. This well drilling operation was carried out in the Municipality of Marechal Deodoro, in the State of Alagoas, in locality named Massagueira. We stress the preventive methods for liquid and solid effluent generation and the use of Closed Fluid System or Anti-Dike System. (author) 3 figs.

  13. Thermal math model analysis of FRSI test article subjected to cold soak and entry environments. [Flexible Reuseable Surface Insulation in Space Shuttle Orbiter (United States)

    Gallegos, J. J.


    A multi-objective test program was conducted at the NASA/JSC Radiant Heat Test Facility in which an aluminum skin/stringer test panel insulated with FRSI (Flexible Reusable Surface Insulation) was subjected to 24 simulated Space Shuttle Orbiter ascent/entry heating cycles with a cold soak in between in the 10th and 20th cycles. A two-dimensional thermal math model was developed and utilized to predict the thermal performance of the FRSI. Results are presented which indicate that the modeling techniques and property values have been proven adequate in predicting peak structure temperatures and entry thermal responses from both an ambient and cold soak condition of an FRSI covered aluminum structure.

  14. Decoding Area Studies and Interdisciplinary Majors: Building a Framework for Entry-Level Students (United States)

    MacPherson, Kristina Ruth


    Decoding disciplinary expertise for novices is increasingly part of the undergraduate curriculum. But how might area studies and other interdisciplinary programs, which require integration of courses from multiple disciplines, decode expertise in a similar fashion? Additionally, as a part of decoding area studies and interdisciplines, how might a…

  15. Hanford Environmental Information System (HEIS). Volume 3, Subject Area reference manual

    Energy Technology Data Exchange (ETDEWEB)

    Schreck, R.I.


    The Hanford Environmental Information System (HEIS) Subject Area manuals are designed as reference guides, that is, each chapter provides the information needed to make best use of each subject area, its tables, and reporting capabilities. Each subject area is documented in a chapter in one of the subject area manuals. Because these are reference manuals, most of the information is also available in the online help system as well. See Section 5.4.2 of the HEIS User`s Guide (DOE-RL 1994a) for a detailed description of the online help.

  16. More than Beliefs: Subject Areas and Teachers' Integration of Laptops in Secondary Teaching (United States)

    Howard, Sarah K.; Chan, Amy; Caputi, Peter


    The purpose of this paper is to explore the relationship of subject areas to teachers' technology integration. Educational technology research has often identified "culture clashes" to explain differences in technology use between subject areas. These clashes are frequently attributed to core features, values and beliefs held in the…

  17. Extent of the availability of Africana resources in subject areas in ...

    African Journals Online (AJOL)

    The study investigated the extent of the availability of Africana resources in various subject areas in thirteen first and second generation federal university libraries in Nigeria with the view of suggesting ways to improve the development of the collection in the university libraries that are deficient in the subject areas of any of ...

  18. Reactogenicity and immunogenicity of measles-rubella combined vaccine in school-entry-aged subjects with naturally acquired measles immunity. (United States)

    Kumagai, Takuji; Ihara, Toshiaki; Nakayama, Tetsuo; Nagata, Nobuo; Kamiya, Hitoshi


    The reintroduction of measles-rubella combined (MR) vaccination to Japan raised concerns about adverse events as well as immunogenicity related to booster immunization in subjects with naturally acquired immunity to measles or rubella. The time course of reactogenicity and antibody responses in recipients with pre-existing immunity to measles through natural infection was observed. Eighteen children aged 80-104 months received MR booster vaccination; 16 of them had had previous rubella vaccination. There were virtually no clinical reactions related to booster vaccination, and a highly significant antibody response to rubella antigen, whereas the antibody rise to measles was statistically significant but poor. Vaccination of individuals already immune is not harmful. Booster immunization to rubella for Japanese children is vitally important. © 2015 Japan Pediatric Society.

  19. Subjectivity

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    Jesús Vega Encabo


    Full Text Available In this paper, I claim that subjectivity is a way of being that is constituted through a set of practices in which the self is subject to the dangers of fictionalizing and plotting her life and self-image. I examine some ways of becoming subject through narratives and through theatrical performance before others. Through these practices, a real and active subjectivity is revealed, capable of self-knowledge and self-transformation. 

  20. Mastication, EMG activity and occlusal contact area in subjects with different facial types. (United States)

    Gomes, Simone Guimarães Farias; Custodio, William; Jufer, Juliana Silva Moura; Del Bel, Cury Altair Antoninha; Garcia, Renata Cunha Matheus Rodrigues


    Dentofacial morphology may affect orofacial functions, therefore the aim of the current study was to evaluate the influence of craniofacial morphology on masticatory function, occlusal contact area (OCA), and masticatory muscles activity. Seventy-eight (78) subjects were divided into three groups according to vertical facial pattern: 1. mesofacial; 2. brachyfacial; and 3. dolichofacial. Artificial material and the sieving method were used to access masticatory efficiency (ME). OCA was determined by registration of posterior teeth. Electromyographic (EMG) activity of the masseter and anterior temporal (AT) muscles was accessed bilaterally at rest and at maximal vertical clenching (MVC). ME (%) was significantly higher in brachyfacial and lower in dolichofacial subjects. Brachyfacials presented the highest OCA (mm2) followed by meso and dolichofacial subjects. The EMG of the masseter and AT at rest and at MVC showed that dolichofacial subjects presented the lowest activity values, while brachyfacial subjects presented significantly higher measurements. Craniofacial morphology affected masticatory function, OCA, and EMG activity of the masticatory muscles.

  1. Increased BDNF promoter methylation in the Wernicke area of suicide subjects. (United States)

    Keller, Simona; Sarchiapone, Marco; Zarrilli, Federica; Videtic, Alja; Ferraro, Angelo; Carli, Vladimir; Sacchetti, Silvana; Lembo, Francesca; Angiolillo, Antonella; Jovanovic, Nikolina; Pisanti, Francesco; Tomaiuolo, Rossella; Monticelli, Antonella; Balazic, Joze; Roy, Alec; Marusic, Andrej; Cocozza, Sergio; Fusco, Alfredo; Bruni, Carmelo B; Castaldo, Giuseppe; Chiariotti, Lorenzo


    Brain-derived neurotrophic factor (BDNF) plays a pivotal role in the pathophysiology of suicidal behavior and BDNF levels are decreased in the brain and plasma of suicide subjects. So far, the mechanisms leading to downregulation of BDNF expression are poorly understood. To test the hypothesis that alterations of DNA methylation could be involved in the dysregulation of BDNF gene expression in the brain of suicide subjects. Three independent quantitative methylation techniques were performed on postmortem samples of brain tissue. BDNF messenger RNA levels were determined by quantitative real-time polymerase chain reaction. Academic medical center. Forty-four suicide completers and 33 nonsuicide control subjects of white ethnicity. The DNA methylation degree at BDNF promoter IV and the genome-wide DNA methylation levels in the brain's Wernicke area. Postmortem brain samples from suicide subjects showed a statistically significant increase of DNA methylation at specific CpG sites in BDNF promoter/exon IV compared with nonsuicide control subjects (P Wernicke area of the postmortem brain of suicide subjects irrespective of genome-wide methylation levels, indicating that a gene-specific increase in DNA methylation could cause or contribute to the downregulation of BDNF expression in suicide subjects. The reported data reveal a novel link between epigenetic alteration in the brain and suicidal behavior.

  2. An investigation on impacts of scheduling configurations on Mississippi biology subject area testing (United States)

    Marchette, Frances Lenora

    The purpose of this mixed modal study was to compare the results of Biology Subject Area mean scores of students on a 4 x 4 block schedule, A/B block schedule, and traditional year-long schedule for 1A to 5A size schools. This study also reviewed the data to determine if minority or gender issues might influence the test results. Interviews with administrators and teachers were conducted about the type of schedule configuration they use and the influence that the schedule has on student academic performance on the Biology Subject Area Test. Additionally, this research further explored whether schedule configurations allow sufficient time for students to construct knowledge. This study is important to schools, teachers, and administrators because it can assist them in considering the impacts that different types of class schedules have on student performance and if ethnic or gender issues are influencing testing results. This study used the causal-comparative method for the quantitative portion of the study and constant comparative method for the qualitative portion to explore the relationship of school schedules on student academic achievement on the Mississippi Biology Subject Area Test. The aggregate means of selected student scores indicate that the Mississippi Biology Subject Area Test as a measure of student performance reveals no significant difference on student achievement for the three school schedule configurations. The data were adjusted for initial differences of gender, minority, and school size on the three schedule configurations. The results suggest that schools may employ various schedule configurations and expect student performance on the Mississippi Biology Subject Area Test to be unaffected. However, many areas of concern were identified in the interviews that might impact on school learning environments. These concerns relate to effective classroom management, the active involvement of students in learning, the adequacy of teacher education

  3. Building Virtually Free Subject Area Expertise through Social Media: An Exploratory Study (United States)

    Kooy, Brian K.


    Central to the ongoing success of the liaison model is the need for liaison librarians to stay informed and up-to-date about recent developments in the subject areas of their assigned academic departments and programs. This article describes an exploratory study conducted to determine whether information obtained from the social media accounts of…

  4. Subject Area Glossary. Arabic-English Vocabulary. Curriculum Bulletin Number 22. (United States)

    Chicago Board of Education, IL. Dept. of Curriculum.

    A glossary of commonly used and subject-area English words and their Arabic equivalents with romanization was prepared for teachers and Arabic-speaking, limited-English-speaking children in the Chicago public schools. It consists of: (1) a key to Arabic pronunciation of velarized consonants, glottal consonants, and Arabic double-consonants; (2) a…

  5. Ascertaining Activities in a Subject Area Through Bibliometric Analysis; Application to "Library Literature" (United States)

    Saracevic, Tefko; Perk, Lawrence J.


    A combination of quantitative and qualitative techniques were used to analize the journal articles indexed in one volume of Library Literature.'' This approach, merging bibliometrics and classification, yielded results in such areas as dispersion of articles among journals, frequency of article type and types of subjects covered. (16 references)…

  6. Perceptions of Classroom Assessment Tasks: An Interplay of Gender, Subject Area, and Grade Level (United States)

    Alkharusi, Hussain Ali; Al-Hosni, Salim


    This study investigates students' perceptions of classroom assessment tasks as a function of gender, subject area, and grade level. Data from 2753 students on Dorman and Knightley's (2006) Perceptions of Assessment Tasks Inventory (PATI) were analyzed in a MANOVA design. Results showed that students tended to hold positive perceptions of their…

  7. A Subject-Specificity Analysis of Radio Channels in Wireless Body Area Networks

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    Yang Hao


    Full Text Available This paper presents an analysis of subject-specific radio channels in wireless body area networks (WBANs using a simulation tool based on the parallel finite-difference time-domain (FDTD technique. This technique is well suited to model radio propagations around complex, inhomogeneous objects such as the human body. The impacts of different subjects varying in size on on-body, inter-body, and off-body radio channels are studied. The analysis demonstrates that the characteristics of on-body radio channels are subject-specific and are associated with human gender, height, and body mass index. On the other hand, when waves propagate away from the body, such as in the inter-body and off-body cases, the impacts of different subjects on the channel characteristics are found to be negligible.

  8. Subjective Evaluations of Motion Area and Velocity Characteristics of Dual Manipulator in Young and Elderly People (United States)

    Yoda, Mitsumasa; Yoda, Asako; Shiota, Yasuhito

    In this study, we conducted a subjective evaluation experiment of a dual manipulator, which exhibits different motion characteristics. There are three motion characteristics: two of which are age-related, and the third is a robot motion characteristic and is newly added to these two motions. The motions are evaluated from motion areas and motion velocities. Subjects are elderly and young people, and the impressions of the motions are compared in two of the different age groups by the Semantic Differential (SD) method. The obtained results indicate that there are age differences in the evaluation of three manipulator motion areas. The elderly people show a higher reliability and a higher familiarity in a robot motion area than in the other two motions. The elderly people seem to be more affected by the manipulator motion than the young people. Therefore, a careful consideration is required when planning the motion of a manipulator for elderly people.

  9. Chewing side, bite force symmetry, and occlusal contact area of subjects with different facial vertical patterns

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    Simone Guimarães Farias Gomes


    Full Text Available Craniofacial dimensions influence oral functions; however, it is not known whether they are associated with function asymmetry. The objective of this study was to evaluate chewing side preference and lateral asymmetry of occlusal contact area and bite force of individuals with different craniofacial patterns. Seventy-eight dentate subjects were divided into 3 groups according to the VERT index as follows: (1 mesofacial, (2 brachyfacial and (3 dolichofacial. Chewing side preference was evaluated using jaw tracking equipment, occlusal contact area was measured by silicon registration of posterior teeth, and bite force was measured unilaterally on molar regions using 2.25 mm-thick sensors. Statistical analysis was performed using ANOVA on Ranks, Student's t-test, and Mann-Whitney tests at a 5% significance level. Mesofacial, brachyfacial, and dolichofacial subjects presented more occlusal contact area on the left side. Only dolichofacial subjects showed lateral asymmetry for bite force, presenting higher force on the left side. No statistically significant differences were found for chewing side preference among all groups. Within the limitations of this study, it can be concluded that craniofacial dimensions play a role in asymmetry of bite force. ID: NCT01286363.

  10. Condylar volume and condylar area in class I, class II and class III young adult subjects

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    Saccucci Matteo


    Full Text Available Abstract Aim Aim of this study was to compare the volume and the shape of mandibular condyles in a Caucasian young adult population, with different skeletal pattern. Material and methods 200 Caucasian patients (15–30 years old, 95 male and 105 females were classified in three groups on the base of ANB angle: skeletal class I (65 patients, skeletal class II (70 patients and skeletal class III (65 patients. Left and right TMJs of each subject were evaluated independently with CBCT (Iluma. TMJ evaluation included: condylar volume; condylar area; morphological index (MI. Condylar volumes were calculated by using the Mimics software. The condylar volume, the area and the morphological index (MI were compared among the three groups, by using non-parametric tests. Results The Kruskal-Wallis test and the Mann Whitney test revealed that: no significant difference was observed in the whole sample between the right and the left condylar volume; subjects in skeletal class III showed a significantly higher condylar volume, respect to class I and class II subjects (p 3 in males and 663.5 ± 81.3 mm3 in females; p 2 in males and 389.76 ± 61.15 mm2 in females; p  Conclusion Skeletal class appeared to be associated to the mandibular condylar volume and to the mandibular condylar area in the Caucasian orthodontic population.

  11. Condylar volume and condylar area in class I, class II and class III young adult subjects. (United States)

    Saccucci, Matteo; D'Attilio, Michele; Rodolfino, Daria; Festa, Felice; Polimeni, Antonella; Tecco, Simona


    Aim of this study was to compare the volume and the shape of mandibular condyles in a Caucasian young adult population, with different skeletal pattern. 200 Caucasian patients (15-30 years old, 95 male and 105 females) were classified in three groups on the base of ANB angle: skeletal class I (65 patients), skeletal class II (70 patients) and skeletal class III (65 patients). Left and right TMJs of each subject were evaluated independently with CBCT (Iluma). TMJ evaluation included: condylar volume; condylar area; morphological index (MI). Condylar volumes were calculated by using the Mimics software. The condylar volume, the area and the morphological index (MI) were compared among the three groups, by using non-parametric tests. The Kruskal-Wallis test and the Mann Whitney test revealed that: no significant difference was observed in the whole sample between the right and the left condylar volume; subjects in skeletal class III showed a significantly higher condylar volume, respect to class I and class II subjects (p condylar volume was observed in class II subjects, respect to class I and class III (p condylar volume (699.8 ± 63.07 mm3 in males and 663.5 ± 81.3 mm3 in females; p condylar surface (423.24 ± 63.03 mm2 in males and 389.76 ± 61.15 mm2 in females; p condylar volume and to the mandibular condylar area in the Caucasian orthodontic population.

  12. [Characterization of the leadership subject areas in the respiratory field in Spain]. (United States)

    de Granda-Orive, J I; García-Río, F; Roig-Vázquez, F; Aleixandre-Benavent, R; Valderrama-Zurían, J C; Martínez-Albiach, J M; Callol-Sánchez, L


    The aim of this study was to characterize the leading topics in respiratory system in Spain through a bibliometric analysis. For identify and characterize the performance of the different research topics in respiratory system in Spain, we compile the production using a journal that turn out representative of a broad group of researcher. In this sense the journal Archivos de Bronconeumología is the most important publication in Spanish language of this field. A total of 2198 articles published in Archivos Bronconeumología from 1970 to 2000 were analyzed. In each three decades, we did not found differences except in the productivity index in oncology in the eighty decade and in respiratory failure and sleep disturbance (RFSD) and oncology areas in the ninetieth decade and in the Price index (consumption indicators) in the diagnostic and therapeutic techniques area in seventy decade. When we compare the productivity index of each subject areas between decades, we found a significant production increase in the ninetieth decade in asthma, RFSD, tuberculosis, non tuberculosis infection, circulation, oncology, pleural disease and interstitial areas versus the same in seventy decade, and also, we found significant differences between ninetieth and eighty decades in the asthma, RFSD, non tuberculosis infection, circulation and pleural disease areas. Tuberculosis area maintains an insularity index higher than the other areas. We also found a progressive increase in the insularity index of RFSD, non tuberculosis infection, oncology and interstitial disease areas. In general all the indicators maintains stable although the more productivity topics were respiratory failure and sleep disturbances, and oncology. The productivity has increased in asthma, respiratory failure and sleep disturbances, tuberculosis, non - tuberculosis respiratory infections, oncology, pulmonary circulation, pleura and interstitial disease.

  13. Data Entry Curriculum. (United States)

    Chinatown Manpower Project, Inc., New York, NY.

    This document describes a project that provides full-time training in the microcomputing area of data entry/word processing as well as job-specific English as a second language (ESL) to adults whose first language is Chinese. The project includes a component that develops the trainees' language proficiency in business communications while…

  14. Blood biomonitoring of metals in subjects living near abandoned mining and active industrial areas. (United States)

    Madeddu, Roberto; Tolu, Paola; Asara, Yolande; Farace, Cristiano; Forte, Giovanni; Bocca, Beatrice


    A human blood biomonitoring campaign to detect the environmental exposure to metals (Cd, Cu, Cr, Mn, Pb and Zn) in 265 subjects was performed in the South-Western part of Sardinia (an Italian island) that is a particular area with a great history of coal and metal mining (Pb/Zn mainly) activities and large industrial structures (as metallurgy). Subjects living near the industrial plant area had geometric means (GM) of blood Cd (0.79 μg/l), Cu (971 μg/l), Mn (12.2 μg/l), and Pb (55.7 μg/l) significantly higher than controls (Cd, 0.47 μg/l; Cu, 900 μg/l; Mn 9.98 μg/l; Pb, 26.5 μg/l) and than people living nearby the past mining sites. Subjects living next to one dismissed mine were statistically higher in blood Cu (GM, 1,022 μg/l) and Pb (GM, 41.4 μg/l) concentrations than controls. No differences were observed in people living in the different mining sites, and this might be related to the decennial disclosure of mines and the adoption of environmental remediation programmes. Some interindividual variables influenced blood biomonitoring data, as smoke and age for Cd, gender for Cu, age, sex and alcohol for Pb, and age for Zn. Moreover, blood metal levels of the whole population were similar to reference values representative of the Sardinian population and acceptably safe according to currently available health guidelines.

  15. 75 FR 26967 - Guidance for Industry: Use of Water by Food Manufacturers in Areas Subject to a Boil-Water... (United States)


    ... Areas Subject to a Boil-Water Advisory; Availability AGENCY: Food and Drug Administration, HHS. ACTION... entitled ``Guidance for Industry: Use of Water by Food Manufacturers in Areas Subject to a Boil-Water Advisory.'' This guidance is intended to advise food manufacturers that once a boil-water advisory has been...

  16. Academic Majors and Subject-Area Certifications of Health Education Teachers in the United States, 2011-2012 (United States)

    Cardina, Catherine


    Purpose: The purpose of this study was to identify academic preparation and subject-area certifications of K-12 public school staff teaching at least one health education class during 2011-2012 academic year. In general, teachers who are well qualified to teach a subject area are more likely to positively affect student achievement. Methods: Data…

  17. Increased cortical area and thickness in the distal radius in subjects with SHOX-gene mutation. (United States)

    Frederiksen, A L; Hansen, S; Brixen, K; Frost, M


    Short-stature homeobox (SHOX) gene haploinsufficiency may cause skeletal dysplasia including Léri-Weill Dyschondrosteosis (LWD), a clinical entity characterised by the triad of low height, mesomelic disproportion and Madelung's deformity of the wrist. Bone microarchitecture and estimated strength in adult SHOX mutation carriers have not been examined. Twenty-two subjects with a SHOX mutation including 7 males and 15 females with a median age of 38.8 [21.1-52.2] years were recruited from five unrelated families. The control group consisted of 22 healthy subjects matched on age and sex. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. Bone geometry, volumetric density, microarchitecture and finite element estimated (FEA) bone strength were measured using high-resolution peripheral quantitative computed tomography (HR-pQCT). A full region of interest (ROI) image analysis and height-matched ROI analyses adjusting for differences in body height between the two groups were performed. Areal BMD and T-scores showed no significant differences between cases and controls. Total radius area was smaller in cases than controls (207 [176-263] vs. 273 [226-298] mm, pRadius cortical bone area (74 ± 20 vs. 58 ± 17 mm(2), p=0.01) and thickness (1.16 ± 0.30 vs. 0.84 ± 0.26 mm, pRadius trabecular bone area (119 [103-192] vs. 202 [168-247] mm(2), pradius and tibia cortical porosity or FEA failure load between groups. A segment of cortical bone defect was identified in the distal radius adjacent to ulna in five unrelated SHOX mutation carriers. Subjects with a SHOX mutation presented with a different bone geometry in radius and tibia while there were no differences in BMD or failure load compared to controls, suggesting that mutations in SHOX gene may have an impact on bone microarchitecture albeit not bone strength. Copyright © 2014 Elsevier Inc. All rights reserved.

  18. Refractive error study in young subjects: results from a rural area in Paraguay (United States)

    Signes-Soler, Isabel; Hernández-Verdejo, José Luis; Estrella Lumeras, Miguel Angel; Tomás Verduras, Elena; Piñero, David P.


    AIM To evaluate the distribution of refractive error in young subjects in a rural area of Paraguay in the context of an international cooperation campaign for the prevention of blindness. METHODS A sample of 1466 young subjects (ranging from 3 to 22 years old), with a mean age of 11.21±3.63 years old, were examined to assess their distance visual acuity (VA) and refractive error. The first screening examination performed by trained volunteers, included visual acuity testing, autokeratometry and non-cycloplegic autorefraction. Inclusion criteria for a second complete cycloplegic eye examination by an optometrist were VA <20/25 (0.10 logMAR or 0.8 decimal) and/or corneal astigmatism ≥1.50 D. RESULTS An uncorrected distance VA of 0 logMAR (1.0 decimal) was found in 89.2% of children. VA <20/25 and/or corneal astigmatism ≥1.50 D was found in 3.9% of children (n=57), with a prevalence of hyperopia of 5.2% (0.2% of the total) in this specific group. Furthermore, myopia (spherical equivalent ≤-0.5 D) was found in 37.7% of the refracted children (0.5% of the total). The prevalence of refractive astigmatism (cylinder ≤-1.50 D) was 15.8% (0.6% of the total). Visual impairment (VI) (0.05≤VA≤0.3) was found in 12/114 (0.4%) of the refracted eyes. Main causes for VI were refractive error (58%), retinal problems (17%, 2/12), albinism (17%, 2/12) and unknown (8%, 1/12). CONCLUSION A low prevalence of refractive error has been found in this rural area of Paraguay, with higher prevalence of myopia than of hyperopia. PMID:28393041

  19. Refractive error study in young subjects: results from a rural area in Paraguay

    Directory of Open Access Journals (Sweden)

    Isabel Signes-Soler


    Full Text Available AIM: To evaluate the distribution of refractive error in young subjects in a rural area of Paraguay in the context of an international cooperation campaign for the prevention of blindness. METHODS: A sample of 1466 young subjects (ranging from 3 to 22 years old, with a mean age of 11.21±3.63 years old, were examined to assess their distance visual acuity (VA and refractive error. The first screening examination performed by trained volunteers, included visual acuity testing, autokeratometry and non-cycloplegic autorefraction. Inclusion criteria for a second complete cycloplegic eye examination by an optometrist were VA <20/25 (0.10 logMAR or 0.8 decimal and/or corneal astigmatism ≥1.50 D. RESULTS: An uncorrected distance VA of 0 logMAR (1.0 decimal was found in 89.2% of children. VA <20/25 and/or corneal astigmatism ≥1.50 D was found in 3.9% of children (n=57, with a prevalence of hyperopia of 5.2% (0.2% of the total in this specific group. Furthermore, myopia (spherical equivalent ≤-0.5 D was found in 37.7% of the refracted children (0.5% of the total. The prevalence of refractive astigmatism (cylinder ≤-1.50 D was 15.8% (0.6% of the total. Visual impairment (VI (0.05≤VA≤0.3 was found in 12/114 (0.4% of the refracted eyes. Main causes for VI were refractive error (58%, retinal problems (17%, 2/12, albinism (17%, 2/12 and unknown (8%, 1/12. CONCLUSION: A low prevalence of refractive error has been found in this rural area of Paraguay, with higher prevalence of myopia than of hyperopia.

  20. Spatial variability of soil potassium in sugarcane areas subjected to the application of vinasse. (United States)

    De Carvalho, Laércio A; Meurer, Ismael; Da Silva Junior, Carlos A; Santos, Cristiane F B; Libardi, Paulo L


    When deposited on land the vinasse can promote improvement in fertility, however, often fertilizer application occurs in areas considered homogeneous, without taking into account the variability of the soil. The objective of this study was to evaluate the effect of vinasse application on potassium content in two classes of soils cultivated with sugarcane, and characterize the spatial variability of soil using geostatistical techniques. In the 2010 and 2011 crop year, soil samples were collected from an experimental grid at 0-0.2 and 0.2-0.4 m depth in three soils cultivated with sugarcane, totaling 90 samplings in each grid, for the determination of pH, calcium (Ca), magnesium (Mg), potassium (K), phosphorus (P), aluminum (Al) and potential acidity (H + Al). The data have been submitted to analysis of descriptive statistics and the K attribute was subjected to geostatistical analysis. The coefficient of variation indicated medium and high variability of K for the three soils. The results showed that the spatial dependence of K increased in depth to FRce and decreased to PHlv, indicating that the attribute could have followed the pattern of distribution of clay in depth. The investigation of the spatial variability of K on the surface and subsurface soils provided the definition of management zones with different levels of fertility, which can be organized into sub-areas for a more efficient management of the resources and the environment.

  1. Spatial variability of soil potassium in sugarcane areas subjected to the application of vinasse

    Directory of Open Access Journals (Sweden)



    Full Text Available When deposited on land the vinasse can promote improvement in fertility, however, often fertilizer application occurs in areas considered homogeneous, without taking into account the variability of the soil. The objective of this study was to evaluate the effect of vinasse application on potassium content in two classes of soils cultivated with sugarcane, and characterize the spatial variability of soil using geostatistical techniques. In the 2010 and 2011 crop year, soil samples were collected from an experimental grid at 0-0.2 and 0.2-0.4 m depth in three soils cultivated with sugarcane, totaling 90 samplings in each grid, for the determination of pH, calcium (Ca, magnesium (Mg, potassium (K, phosphorus (P, aluminum (Al and potential acidity (H + Al. The data have been submitted to analysis of descriptive statistics and the K attribute was subjected to geostatistical analysis. The coefficient of variation indicated medium and high variability of K for the three soils. The results showed that the spatial dependence of K increased in depth to FRce and decreased to PHlv, indicating that the attribute could have followed the pattern of distribution of clay in depth. The investigation of the spatial variability of K on the surface and subsurface soils provided the definition of management zones with different levels of fertility, which can be organized into sub-areas for a more efficient management of the resources and the environment.


    Directory of Open Access Journals (Sweden)

    P. P. Oleynik


    Full Text Available The paper deals with domain-driven design applicability of information systems for client queuing subject areas. The following optimality criteria were put forward for the final implementation: the possibility of automation with a single system both for small institution and a whole network of institutions; advanced graphical interface with support for sensor screens; implementation of multi-users account of orders from clients; flexible application architecture with the ability of future enhancement; ability of integration with a variety of peripherals. The necessity of each criterion definition is shown. For implementability estimation, test information system was designed, automating the queuing system. Unified modeling language UML is used. Description of each class functionality is given and the association with other classes as well. Attention is paid to the design of tree (hierarchical structures and selection procedure of base classes based on the analysis of existing common attributes. For the system implementation, its own development environment SharpArchitect RAD Studio is used, offering MDA approach for implementation of systems based on standardized meta object system. A graphical view of order form developed prototype is presented, composition and structure are described, and notation developed by the author is given simplifying the prototyping process. Approaches to differentiation of access rights for different user roles are shown. Conformity of the received implementation to each selected optimality criterion is determined. Recommendations for further system development are given.

  3. How predictive are sex and empathizing-systemizing cognitive style for entry into the academic areas of social or physical sciences? (United States)

    Groen, Y; Fuermaier, A B M; Tucha, L I; Koerts, J; Tucha, O


    Based on the Empathizing-Systemizing (E-S) theory, it was hypothesized that the underrepresentation of female students in the physical sciences and the underrepresentation of males in the social sciences relates to differences in E-S cognitive style between the sexes. This hypothesis was tested in 115 physical science students and 155 social science students from a university in the Netherlands. The students completed visuospatial tests and the systemizing quotient-revised (SQ-R) as measures for systemizing, and a Cartoon Prediction test and the empathy quotient (EQ) as measures for empathizing. Independent of sex, the physical science students scored significantly lower than social science students on EQ (with large effect size) and 'brain type' that represents the standardized difference score between EQ and SQ-R (with large effect size). Physical science students, furthermore, scored significantly higher on the Cartoon Prediction task and one of the visuospatial tasks; however, these effects were only small of size. Unlike the scores on the SQ-R and the performance tests, the 'brain type' score of the EQ and SQ-R questionnaires was a good predictor of entry into social or physical sciences. Interestingly, the typical sex differences in more empathizing and less systemizing in females compared to males were only small for EQ and 'brain type', and absent for the SQ-R and the performance tests. This study only partially confirms the E-S theory, because typical sex differences were only minor in this selective sample and only the self-report measures predicted academic area in the absence of a role for sex.

  4. US Ports of Entry (United States)

    Department of Homeland Security — HSIP Non-Crossing Ports-of-Entry A Port of Entry is any designated place at which a CBP officer is authorized to accept entries of merchandise to collect duties, and...

  5. Intra-Rater Reliability of Rehabilitative Ultrasound Imaging for Multifidus Muscles Thickness and Cross Section Area in Healthy Subjects


    Hosseinifar, Mohammad; Akbari, Asghar; Ghiasi, Fateme


    Introduction: Rehabilitative Ultrasound Imaging (RUSI) must be valuable method for research and rehabilitation. So, the reliability of its measurements must be determined. The purpose of this study was to evaluate the intra-rater reliability of RUSI for measurement of multifidus (MF) muscles cross section areas (CSAs), bladder wall diameter, and thickness of MF muscles between 2 sessions in healthy subjects. Method: Fifteen healthy subjects through simple non-probability sampling participated...

  6. Economics of Scholarly Publishing: Exploring the Causes of Subscription Price Variations of Scholarly Journals in Business Subject-Specific Areas (United States)

    Liu, Lewis G.


    This empirical research investigates subscription price variations of scholarly journals in five business subject-specific areas using the semilogarithmic regression model. It has two main purposes. The first is to address the unsettled debate over whether or not and to what extent commercial publishers reap monopoly profits by overcharging…

  7. Performance Gaps between Online and Face-to-Face Courses: Differences across Types of Students and Academic Subject Areas (United States)

    Xu, Di; Jaggars, Shanna S.


    Using a dataset containing nearly 500,000 courses taken by over 40,000 community and technical college students in Washington State, this study examines the performance gap between online and face-to-face courses and how the size of that gap differs across student subgroups and academic subject areas. While all types of students in the study…

  8. Problem Solving and Creativity and Design: What Influence Do They Have on Girls' Interest in STEM Subject Areas? (United States)

    Cooper, Robyn; Heaverlo, Carol


    For girls there is a distinct loss in interest, lack of confidence, and decline in positive attitudes toward STEM subject areas that begins early on in their academic experience and increases with age. According to the National Academy of Engineering, students need to begin associating the possibilities in STEM fields with the need for creativity…

  9. Reproducibility and repeatability of foveal avascular zone area measurements using swept-source optical coherence tomography angiography in healthy subjects. (United States)

    Mastropasqua, Rodolfo; Toto, Lisa; Mattei, Peter A; Di Nicola, Marta; Zecca, Isaia A L; Carpineto, Paolo; Di Antonio, Luca


    To assess the reproducibility and repeatability of foveal avascular zone (FAZ) area measurements using swept-source optical coherence tomography angiography (SS-OCTA) in healthy subjects. Sixty-four eyes of 64 healthy volunteers were randomly subjected to FAZ area measurements using SS-OCTA by 2 examiners in 2 different sessions. The FAZ areas measured by the first and second observer were 0.269 ± 0.092 mm2 and 0.270 ± 0.090 mm2, respectively. Within subjects, the coefficients of variations were 2.44% (95% confidence interval [CI] 1.95% to 2.93%) and 2.66% (95% CI 2.00% to 3.31%) for the first and second observers, respectively. The coefficient of repeatability average measurements of FAZ area were 0.021 mm2 and 0.024 mm2. The intraclass correlation coefficient values were 0.993 (95% CI 0.989 to 0.996) and 0.991 (95% CI 0.986 to 0.995). Interobserver and intraobserver concordance correlation coefficients ranged from 0.998 (95% CI 0.997 to 0.999) to 0.999 (95% CI 0.998 to 0.999) and from 0.989 (95% CI 0.982 to 0.993) to 0.987 (95% CI 0.979 to 0.992), respectively. The FAZ area measurements by means of SS-OCTA showed high reproducibility and repeatability in healthy eyes.

  10. Condylar volume and condylar area in class I, class II and class III young adult subjects


    Saccucci Matteo; D’Attilio Michele; Rodolfino Daria; Festa Felice; Polimeni Antonella; Tecco Simona


    Abstract Aim Aim of this study was to compare the volume and the shape of mandibular condyles in a Caucasian young adult population, with different skeletal pattern. Material and methods 200 Caucasian patients (15–30 years old, 95 male and 105 females) were classified in three groups on the base of ANB angle: skeletal class I (65 patients), skeletal class II (70 patients) and skeletal class III (65 patients). Left and right TMJs of each subject were evaluated independently with CBCT (Iluma). ...

  11. MEG reveals a fast pathway from somatosensory cortex to occipital areas via posterior parietal cortex in a blind subject

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    Andreas A Ioannides


    Full Text Available Cross-modal activity in visual cortex of blind subjects has been reported during performance of variety of non-visual tasks. A key unanswered question is through which pathways non-visual inputs are funneled to the visual cortex. Here we used tomographic analysis of single trial magnetoencephalography (MEG data recorded from one congenitally blind and two sighted subjects after stimulation of the left and right median nerves at three intensities: below sensory threshold, above sensory threshold and above motor threshold; the last sufficient to produce thumb twitching. We identified reproducible brain responses in the primary somatosensory (S1 and motor (M1 cortices at around 20 ms post-stimulus, which were very similar in sighted and blind subjects. Time-frequency analysis revealed strong 45 to 70 Hz activity at latencies of 20 to 50 ms in S1 and M1, and posterior parietal cortex Brodmann areas (BA 7 and 40, which compared to lower frequencies, were substantially more pronounced in the blind than the sighted subjects. Critically, at frequencies from α-band up to 100 Hz we found clear, strong and widespread responses in the visual cortex of the blind subject, which increased with the intensity of the somatosensory stimuli. Time-delayed mutual information (MI revealed that in blind subject the stimulus information is funneled from the early somatosensory to visual cortex through posterior parietal BA 7 and 40, projecting first to visual areas V5 and V3, and eventually V1. The flow of information through this pathway occured in stages characterized by convergence of activations into specific cortical regions. In sighted subjects, no linked activity was found that led from the somatosensory to the visual cortex through any of the studied brain regions. These results provide the first evidence from MEG that in blind subjects, tactile information is routed from primary somatosensory to occipital cortex via the posterior parietal cortex.

  12. MEG reveals a fast pathway from somatosensory cortex to occipital areas via posterior parietal cortex in a blind subject. (United States)

    Ioannides, Andreas A; Liu, Lichan; Poghosyan, Vahe; Saridis, George A; Gjedde, Albert; Ptito, Maurice; Kupers, Ron


    Cross-modal activity in visual cortex of blind subjects has been reported during performance of variety of non-visual tasks. A key unanswered question is through which pathways non-visual inputs are funneled to the visual cortex. Here we used tomographic analysis of single trial magnetoencephalography (MEG) data recorded from one congenitally blind and two sighted subjects after stimulation of the left and right median nerves at three intensities: below sensory threshold, above sensory threshold and above motor threshold; the last sufficient to produce thumb twitching. We identified reproducible brain responses in the primary somatosensory (S1) and motor (M1) cortices at around 20 ms post-stimulus, which were very similar in sighted and blind subjects. Time-frequency analysis revealed strong 45-70 Hz activity at latencies of 20-50 ms in S1 and M1, and posterior parietal cortex Brodmann areas (BA) 7 and 40, which compared to lower frequencies, were substantially more pronounced in the blind than the sighted subjects. Critically, at frequencies from α-band up to 100 Hz we found clear, strong, and widespread responses in the visual cortex of the blind subject, which increased with the intensity of the somatosensory stimuli. Time-delayed mutual information (MI) revealed that in blind subject the stimulus information is funneled from the early somatosensory to visual cortex through posterior parietal BA 7 and 40, projecting first to visual areas V5 and V3, and eventually V1. The flow of information through this pathway occurred in stages characterized by convergence of activations into specific cortical regions. In sighted subjects, no linked activity was found that led from the somatosensory to the visual cortex through any of the studied brain regions. These results provide the first evidence from MEG that in blind subjects, tactile information is routed from primary somatosensory to occipital cortex via the posterior parietal cortex.

  13. Cross-Modal Recruitment of Auditory and Orofacial Areas During Sign Language in a Deaf Subject. (United States)

    Martino, Juan; Velasquez, Carlos; Vázquez-Bourgon, Javier; de Lucas, Enrique Marco; Gomez, Elsa


    Modern sign languages used by deaf people are fully expressive, natural human languages that are perceived visually and produced manually. The literature contains little data concerning human brain organization in conditions of deficient sensory information such as deafness. A deaf-mute patient underwent surgery of a left temporoinsular low-grade glioma. The patient underwent awake surgery with intraoperative electrical stimulation mapping, allowing direct study of the cortical and subcortical organization of sign language. We found a similar distribution of language sites to what has been reported in mapping studies of patients with oral language, including 1) speech perception areas inducing anomias and alexias close to the auditory cortex (at the posterior portion of the superior temporal gyrus and supramarginal gyrus); 2) speech production areas inducing speech arrest (anarthria) at the ventral premotor cortex, close to the lip motor area and away from the hand motor area; and 3) subcortical stimulation-induced semantic paraphasias at the inferior fronto-occipital fasciculus at the temporal isthmus. The intraoperative setup for sign language mapping with intraoperative electrical stimulation in deaf-mute patients is similar to the setup described in patients with oral language. To elucidate the type of language errors, a sign language interpreter in close interaction with the neuropsychologist is necessary. Sign language is perceived visually and produced manually; however, this case revealed a cross-modal recruitment of auditory and orofacial motor areas. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Estimating species – area relationships by modeling abundance and frequency subject to incomplete sampling (United States)

    Yamaura, Yuichi; Connor, Edward F.; Royle, Andy; Itoh, Katsuo; Sato, Kiyoshi; Taki, Hisatomo; Mishima, Yoshio


    Models and data used to describe species–area relationships confound sampling with ecological process as they fail to acknowledge that estimates of species richness arise due to sampling. This compromises our ability to make ecological inferences from and about species–area relationships. We develop and illustrate hierarchical community models of abundance and frequency to estimate species richness. The models we propose separate sampling from ecological processes by explicitly accounting for the fact that sampled patches are seldom completely covered by sampling plots and that individuals present in the sampling plots are imperfectly detected. We propose a multispecies abundance model in which community assembly is treated as the summation of an ensemble of species-level Poisson processes and estimate patch-level species richness as a derived parameter. We use sampling process models appropriate for specific survey methods. We propose a multispecies frequency model that treats the number of plots in which a species occurs as a binomial process. We illustrate these models using data collected in surveys of early-successional bird species and plants in young forest plantation patches. Results indicate that only mature forest plant species deviated from the constant density hypothesis, but the null model suggested that the deviations were too small to alter the form of species–area relationships. Nevertheless, results from simulations clearly show that the aggregate pattern of individual species density–area relationships and occurrence probability–area relationships can alter the form of species–area relationships. The plant community model estimated that only half of the species present in the regional species pool were encountered during the survey. The modeling framework we propose explicitly accounts for sampling processes so that ecological processes can be examined free of sampling artefacts. Our modeling approach is extensible and could be applied

  15. Magneto encephalography (MEG: perspectives of speech areas functional mapping in human subjects

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    Butorina A. V.


    Full Text Available One of the main problems in clinical practice and academic research is how to localize speech zones in the human brain. Two speech areas (Broca and Wernicke areas that are responsible for language production and for understanding of written and spoken language have been known since the past century. Their location and even hemispheric lateralization have a substantial inter-individual variability, especially in neurosurgery patients. Wada test is one of the most frequently used invasive methodology for speech hemispheric lateralization in neurosurgery patients. However, besides relatively high-risk of Wada test for patient's health, it has its own limitation, e. g. low reliability of Wada-based evidence of verbal memory brain lateralization. Therefore, there is an urgent need for non-invasive, reliable methods of speech zones mapping.The current review summarizes the recent experimental evidence from magnitoencephalographic (MEG research suggesting that speech areas are included in the speech processing within the first 200 ms after the word onset. The electro-magnetic response to deviant word, mismatch negativity wave with latency of 100—200 ms, can be recorded from auditory cortex within the oddball-paradigm. We provide the arguments that basic features of this brain response, such as its automatic, pre-attentive nature, high signal to noise ratio, source localization at superior temporal sulcus, make it a promising vehicle for non-invasive MEG-based speech areas mapping in neurosurgery.

  16. Subject-specific computational modeling of DBS in the PPTg area (United States)

    Zitella, Laura M.; Teplitzky, Benjamin A.; Yager, Paul; Hudson, Heather M.; Brintz, Katelynn; Duchin, Yuval; Harel, Noam; Vitek, Jerrold L.; Baker, Kenneth B.; Johnson, Matthew D.


    Deep brain stimulation (DBS) in the pedunculopontine tegmental nucleus (PPTg) has been proposed to alleviate medically intractable gait difficulties associated with Parkinson's disease. Clinical trials have shown somewhat variable outcomes, stemming in part from surgical targeting variability, modulating fiber pathways implicated in side effects, and a general lack of mechanistic understanding of DBS in this brain region. Subject-specific computational models of DBS are a promising tool to investigate the underlying therapy and side effects. In this study, a parkinsonian rhesus macaque was implanted unilaterally with an 8-contact DBS lead in the PPTg region. Fiber tracts adjacent to PPTg, including the oculomotor nerve, central tegmental tract, and superior cerebellar peduncle, were reconstructed from a combination of pre-implant 7T MRI, post-implant CT, and post-mortem histology. These structures were populated with axon models and coupled with a finite element model simulating the voltage distribution in the surrounding neural tissue during stimulation. This study introduces two empirical approaches to evaluate model parameters. First, incremental monopolar cathodic stimulation (20 Hz, 90 μs pulse width) was evaluated for each electrode, during which a right eyelid flutter was observed at the proximal four contacts (−1.0 to −1.4 mA). These current amplitudes followed closely with model predicted activation of the oculomotor nerve when assuming an anisotropic conduction medium. Second, PET imaging was collected OFF-DBS and twice during DBS (two different contacts), which supported the model predicted activation of the central tegmental tract and superior cerebellar peduncle. Together, subject-specific models provide a framework to more precisely predict pathways modulated by DBS. PMID:26236229

  17. Subject-specific computational modeling of DBS in the PPTg area

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    Laura M. Zitella


    Full Text Available Deep brain stimulation (DBS in the pedunculopontine tegmental nucleus (PPTg has been proposed to alleviate medically intractable gait difficulties associated with Parkinson’s disease. Clinical trials have shown somewhat variable outcomes, stemming in part from surgical targeting variability, modulating fiber pathways implicated in side effects, and a general lack of mechanistic understanding of DBS in this brain region. Subject-specific computational models of DBS are a promising tool to investigate the underlying therapy and side effects. In this study, a parkinsonian rhesus macaque was implanted unilaterally with an 8-contact DBS lead in the PPTg region. Fiber tracts adjacent to PPTg, including the oculomotor nerve, central tegmental tract, and superior cerebellar peduncle, were reconstructed from a combination of pre-implant 7T MRI, post-implant CT, and post-mortem histology. These structures were populated with axon models and coupled with a finite element model simulating the voltage distribution in the surrounding neural tissue during stimulation. This study introduces two empirical approaches to evaluate model parameters. First, incremental monopolar cathodic stimulation (20Hz, 90µs pulse width was evaluated for each electrode, during which a right eyelid flutter was observed at the proximal four contacts (-1.0 to -1.4mA. These current amplitudes followed closely with model predicted activation of the oculomotor nerve when assuming an anisotropic conduction medium. Second, PET imaging was collected OFF-DBS and twice during DBS (two different contacts, which supported the model predicted activation of the central tegmental tract and superior cerebellar peduncle. Together, subject-specific models provide a framework to more precisely predict pathways modulated by DBS.

  18. Modelling of E. coli distribution in coastal areas subjected to combined sewer overflows. (United States)

    De Marchis, Mauro; Freni, Gabriele; Napoli, Enrico


    Rivers, lakes and the sea were the natural receivers of raw urban waste and storm waters for a long time but the low sustainability of such practice, the increase of population and a renewed environmental sensibility increased researcher interest in the analysis and mitigation of the impact of urban waters on receiving water bodies (RWB). In Europe, the integrated modelling of drainage systems and RWB has been promoted as a promising approach for implementing the Water Framework Directive. A particular interest is given to the fate of pathogens and especially of Escherichia coli, in all the cases in which an interaction between population and the RWB is foreseen. The present paper aims to propose an integrated water quality model involving the analysis of several sewer systems (SS) discharging their polluting overflows on the coast in a sensitive marine environment. From a modelling point of view, the proposed application integrated one-dimensional drainage system models with a complex three-dimensional model analysing the propagation in space and time of E. coli in the coastal marine area. The integrated approach was tested in a real case study (the Acicastello bay in Italy) where data were available both for SS model and for RWB propagation model calibration. The analysis shows a good agreement between the model and monitored data. The integrated model was demonstrated to be a valuable tool for investigating the pollutant propagation and to highlight the most impacted areas.

  19. CO2 sequestration in two mediterranean dune areas subjected to a different level of anthropogenic disturbance (United States)

    Bonito, Andrea; Ricotta, Carlo; Iberite, Mauro; Gratani, Loretta; Varone, Laura


    Coastal sand dunes are among the most threatened habitats, especially in the Mediterranean Basin, where the high levels of human pressure impair the presence of plant species, putting at risk the maintenance of the ecosystem services, such as CO2 sequestration provided by these habitats. The aim of this study was to analyze how disturbance-induced changes in plant species abundance patterns account for variations in annual CO2 sequestration flow (CS) of Mediterranean sand dune areas. Two sites characterized by a high (site HAD) and a lower (site LAD) anthropogenic disturbance level were selected. At both sites, plant species number, cover, height and CS based on net photosynthesis measurements were sampled. At the plant species level, our results highlighted that Ammophila arenaria and Pancratium maritimum, had a key role in CS. Moreover, the results revealed a patchy species assemblage in both sites. In particular, HAD was characterized by a higher extension of the anthropogenic aphytoic zone (64% of the total transect length) than LAD. In spite of the observed differences in plant species composition, there were not significant differences between HAD and LAD in structural and functional traits, such as plant height and net photosynthesis. As a consequence, HAD and LAD had a similar CS (443 and 421 Mg CO2 ha-1 y-1, respectively). From a monetary point of view, our estimates based on the social costs of carbon revealed that the flow of sequestered CO2 valued on an average 3181 ± 114 ha-1 year-1 (mean value for the two sites). However, considering also the value of the CO2 negative flow related to loss of vegetated area, the annual net benefit arising from CO2 sequestration amounted to 1641 and 1772 for HAD and LAD, respectively. Overall, the results highlighted the importance to maximize the efforts to preserve dune habitats by applying an effective management policy, which could allow maintaining also a regulatory ecosystem service such as CO2 sequestration.

  20. Population aging in local areas and subjective well-being of older adults: Findings from two studies in Japan. (United States)

    Saito, Tami; Sugisawa, Hidehiro; Harada, Ken; Kai, Ichiro


    Subjective well-being (SWB) of older adults could be affected by both individual and community characteristics. However, the effect of community characteristics, such as population aging in local areas, remains unclear. This study examined the cross-sectional and longitudinal associations between the area-level population aging and SWB of older individuals from two distinct surveys. Those analyzed were 572 respondents aged 75 years and older for a cross-sectional survey in a metropolitan area in Tokyo, Japan (Study 1) and 1,257 and 859 respondents for a cross-sectional and longitudinal analysis, respectively, for a 2-year longitudinal survey project in urban and rural areas of Fukui Prefecture (Study 2). Area-level population aging was assessed by the number of people aged 65 years or older per 100 residents. SWB was assessed with the Life Satisfaction Index-A (LSIA). Multilevel analysis was performed to examine unconditional and conditional associations between the area-level number of older adults per 100 residents and the individual-level LSIA scores. The area-level number of older adults per 100 residents was significantly and positively associated with the LSIA scores in Study 1 (p = 0.042), even after controlling for the area- and individual-level covariates. In Study 2, we also found a significant effect of the area-level number of older adults per 100 residents on LSIA scores in the longitudinal multivariate analysis (p = 0.049). Findings from two survey projects suggested cross-validity in the positive effect of area-level population aging on older adults' SWB. Policymakers should consider older citizens' SWB in the recent urban-to-rural migration governmental policy as well as in urban renovation planning.

  1. The Difference in Translaminar Pressure Gradient and Neuroretinal Rim Area in Glaucoma and Healthy Subjects

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    Lina Siaudvytyte


    Full Text Available Purpose. To assess differences in translaminar pressure gradient (TPG and neuroretinal rim area (NRA in patients with normal tension glaucoma (NTG, high tension glaucoma (HTG, and healthy controls. Methods. 27 patients with NTG, HTG, and healthy controls were included in the prospective pilot study (each group consisted of 9 patients. Intraocular pressure (IOP, intracranial pressure (ICP, and confocal laser scanning tomography were assessed. TPG was calculated as the difference of IOP minus ICP. ICP was measured using noninvasive two-depth transcranial Doppler device. The level of significance P 0.05. The difference between TPG for healthy (5.4(7.7 mmHg and glaucomatous eyes (NTG 6.3(3.1 mmHg, HTG 15.7(7.7 mmHg was statistically significant (P < 0.001. Higher TPG was correlated with decreased NRA (r = −0.83; P = 0.01 in the NTG group. Conclusion. Translaminar pressure gradient was higher in glaucoma patients. Reduction of NRA was related to higher TPG in NTG patients. Further prospective studies are warranted to investigate the involvement of TPG in glaucoma management.

  2. Sonographic measurements of low-echoic synovial area in the dorsal aspect of metatarsophalangeal joints in healthy subjects. (United States)

    Hiraga, Masao; Ikeda, Kei; Shigeta, Koichiro; Sato, Akito; Yoshitama, Tamami; Hara, Ryota; Tanaka, Yasuhito


    Assessment of synovitis in the metatarsophalangeal (MTP) joints with ultrasound has been shown to improve the accuracy of assessment of rheumatoid arthritis (RA). However, the presence of intraarticular low-echoic synovial area (LESA) in the MTP joints in healthy subjects complicates the sonographic assessment of these joints. Healthy subjects with no arthritic symptoms in their MTP joints were recruited. All subjects completed a questionnaire and underwent physical examination and sonographic assessment. LESAs in the dorsal aspect of all MTP joints were measured in the longitudinal view. One thousand non-arthritic MTP joints in 100 healthy subjects (female 73, mean age 41.0 years old) were evaluated. Measurable LESAs were identified in all joints assessed. Mean length of LESA in each of the 1st-5th MTP joints was 17.8, 13.9, 11.9, 10.6, and 9.2 mm, respectively, whereas mean thickness was 2.4, 2.4, 1.8, 1.2, and 0.8 mm, respectively. Multivariate linear regression models identified the difference between 1st and 5th MTP joints as the most independently influential factor on the measurement of LESA. Our data provide the normal reference values for the measurements of LESA in Japanese, which should be taken into consideration when the synovitis in MTP joints is evaluated with ultrasound.

  3. Comparison of optic area measurement using fundus photography and optical coherence tomography between optic nerve head drusen and control subjects. (United States)

    Flores-Rodríguez, Patricia; Gili, Pablo; Martín-Ríos, María Dolores; Grifol-Clar, Eulalia


    To compare optic disc area measurement between optic nerve head drusen (ONHD) and control subjects using fundus photography, time-domain optical coherence tomography (TD-OCT) and spectral-domain optical coherence tomography (SD-OCT). We also made a comparison between each of the three techniques. We performed our study on 66 eyes (66 patients) with ONHD and 70 healthy control subjects (70 controls) with colour ocular fundus photography at 20º (Zeiss FF 450 IR plus), TD-OCT (Stratus OCT) with the Fast Optic Disc protocol and SD-OCT (Cirrus OCT) with the Optic Disc Cube 200 × 200 protocol for measurement of the optic disc area. The measurements were made by two observers and in each measurement a correction of the image magnification factor was performed. Measurement comparison using the Student's t-test/Mann-Whitney U test, the intraclass correlation coefficient, Pearson/Spearman rank correlation coefficient and the Bland-Altman plot was performed in the statistical analysis. Mean and standard deviation (SD) of the optic disc area in ONHD and in controls was 2.38 (0.54) mm(2) and 2.54 (0.42) mm(2), respectively with fundus photography; 2.01 (0.56) mm(2) and 1.66 (0.37) mm(2), respectively with TD-OCT, and 2.03 (0.49) mm(2) and 1.75 (0.38) mm(2), respectively with SD-OCT. In ONHD and controls, repeatability of optic disc area measurement was excellent with fundus photography and optical coherence tomography (TD-OCT and SD-OCT), but with a low degree of agreement between both techniques. Optic disc area measurement is smaller in ONHD compared to healthy subjects with fundus photography, unlike time-domain and spectral-domain optical coherence tomography in which the reverse is true. Both techniques offer good repeatability, but a low degree of correlation and agreement, which means that optic disc area measurement is not interchangeable or comparable between techniques. Ophthalmic & Physiological Optics © 2013 The College of Optometrists.

  4. Fourier power, subjective distance and object categories all provide plausible models of BOLD responses in scene-selective visual areas

    Directory of Open Access Journals (Sweden)

    Mark Daniel Lescroart


    Full Text Available Perception of natural visual scenes activates several functional areas in the human brain, including the Parahippocampal Place Area (PPA, Retrosplenial Complex (RSC, and the Occipital Place Area (OPA. It is currently unclear what specific scene-related features are represented in these areas. Previous studies have suggested that PPA, RSC, and/or OPA might represent at least three qualitatively different classes of features: (1 2D features related to Fourier power; (2 3D spatial features such as the distance to objects in a scene; or (3 abstract features such as the categories of objects in a scene. To determine which of these hypotheses best describes the visual representation in scene-selective areas, we applied voxel-wise modeling (VM to BOLD fMRI responses elicited by a set of 1,386 images of natural scenes. VM provides an efficient method for testing competing hypotheses by comparing predictions of brain activity based on encoding models that instantiate each hypothesis. Here we evaluated three different encoding models that instantiate each of the three hypotheses listed above. We used linear regression to fit each encoding model to the fMRI data recorded from each voxel, and we evaluated each fit model by estimating the amount of variance it predicted in a withheld portion of the data set. We found that voxel-wise models based on Fourier power or the subjective distance to objects in each scene predicted much of the variance predicted by a model based on object categories. Furthermore, the response variance explained by these three models is largely shared, and the individual models explain little unique variance in responses. Based on an evaluation of previous studies and the data we present here, we conclude that there is currently no good basis to favor any one of the three alternative hypotheses about visual representation in scene-selective areas. We offer suggestions for further studies that may help resolve this issue.

  5. Fourier power, subjective distance, and object categories all provide plausible models of BOLD responses in scene-selective visual areas (United States)

    Lescroart, Mark D.; Stansbury, Dustin E.; Gallant, Jack L.


    Perception of natural visual scenes activates several functional areas in the human brain, including the Parahippocampal Place Area (PPA), Retrosplenial Complex (RSC), and the Occipital Place Area (OPA). It is currently unclear what specific scene-related features are represented in these areas. Previous studies have suggested that PPA, RSC, and/or OPA might represent at least three qualitatively different classes of features: (1) 2D features related to Fourier power; (2) 3D spatial features such as the distance to objects in a scene; or (3) abstract features such as the categories of objects in a scene. To determine which of these hypotheses best describes the visual representation in scene-selective areas, we applied voxel-wise modeling (VM) to BOLD fMRI responses elicited by a set of 1386 images of natural scenes. VM provides an efficient method for testing competing hypotheses by comparing predictions of brain activity based on encoding models that instantiate each hypothesis. Here we evaluated three different encoding models that instantiate each of the three hypotheses listed above. We used linear regression to fit each encoding model to the fMRI data recorded from each voxel, and we evaluated each fit model by estimating the amount of variance it predicted in a withheld portion of the data set. We found that voxel-wise models based on Fourier power or the subjective distance to objects in each scene predicted much of the variance predicted by a model based on object categories. Furthermore, the response variance explained by these three models is largely shared, and the individual models explain little unique variance in responses. Based on an evaluation of previous studies and the data we present here, we conclude that there is currently no good basis to favor any one of the three alternative hypotheses about visual representation in scene-selective areas. We offer suggestions for further studies that may help resolve this issue. PMID:26594164

  6. Intra-Rater Reliability of Rehabilitative Ultrasound Imaging for Multifidus Muscles Thickness and Cross Section Area in Healthy Subjects. (United States)

    Hosseinifar, Mohammad; Akbari, Asghar; Ghiasi, Fateme


    Rehabilitative Ultrasound Imaging (RUSI) must be valuable method for research and rehabilitation. So, the reliability of its measurements must be determined. The purpose of this study was to evaluate the intra-rater reliability of RUSI for measurement of multifidus (MF) muscles cross section areas (CSAs), bladder wall diameter, and thickness of MF muscles between 2 sessions in healthy subjects. Fifteen healthy subjects through simple non-probability sampling participated in this single-group repeated-measures reliability study. MF muscles thickness at rest and during contraction, MF muscles CSAs at rest, and bladder diameters at rest and during pelvic floor muscles (PFM) contraction were measured through RUSI. Pearson's correlation coefficient test was used to determine intra-rater reliability of variables. The results showed that intra-class correlation Coefficient (ICCs) values with 95% confidence interval (CI) and the standard error of the measurement (SEM) were good to excellent agreement for a single investigator between measurement occasions. The intra-rater reliability for the bladder wall displacement was high (ICCs for rest and PFM contraction state: 0.96 and 0.95 respectively), for the MF muscles CSAs at the L4 level was good to high (ICCs 0.75 and 0.91 for right (Rt) and left (Lt) side respectively), and for the thickness of MF muscles at two levels, at rest and during two tasks was moderate to high (ICCs: 0.64 to 0.87). The Trans-Abdominal (TA) method of RUSI is a reliable method to quantify the PFM contraction in healthy subjects. Also, the RUSI is a reliable method to measure the MF muscles CSAs, the MF muscles thickness at rest and during functional tasks in healthy subjects.

  7. Entry at Venus (United States)

    Venkatapathy, Ethiraj; Smith, Brandon


    This is lecture to be given at the IPPW 2016, as part of the 2 day course on Short Course on Destination Venus: Science, Technology and Mission Architectures. The attached presentation material is intended to be introduction to entry aspects of Venus in-situ robotic missions. The presentation introduces the audience to the aerodynamic and aerothermodynamic aspects as well as the loads, both aero and thermal, generated during entry. The course touches upon the system design aspects such as TPS design and both high and low ballistic coefficient entry system concepts that allow the science payload to be protected from the extreme entry environment and yet meet the mission objectives.

  8. Interval estimation for the area under the receiver operating characteristic curve when data are subject to error. (United States)

    Li, Yanhong; Koval, John J; Donner, Allan; Zou, G Y


    The area (A) under the receiver operating characteristic curve is commonly used to quantify the ability of a biomarker to correctly classify individuals into two populations. However, many markers are subject to measurement error, which must be accounted for to prevent understating their effectiveness. In this paper, we develop a new confidence interval procedure for A which is adjusted for measurement error using either external or internal replicated measurements. Based on the observation that A is a function of normal means and variances, we develop the procedure by recovering variance estimates needed from confidence limits for normal means and variances. Simulation results show that the procedure performs better than the previous ones based on the delta-method in terms of coverage percentage, balance of tail errors and interval width. Two examples are presented. Copyright © 2010 John Wiley & Sons, Ltd.

  9. A case study of full integration of the arts into core subject area instruction in one East Texas secondary school (United States)

    Leysath, Maggie

    This exploratory phenomenological case study investigated the influence the full integration of the arts into core subject instruction has on classroom environment, student academic achievement, and student engagement as perceived by administrators, teachers, and students in one East Texas secondary school. Participant interviews were analyzed using Creswell's (2012) six-step method for analyzing phenomenological studies. The researcher implemented three learning activities in which ceramics learning objectives were fully integrated with chemistry learning objectives. The first activity combined clay properties and pottery wheel throwing with significant numbers. The second activity combined glaze formulation with moles. The third combined stoichiometry with the increased glaze formula for students to glaze the bowls they made. Findings suggest the full integration of art in core subject area instruction has numerous positive effects. Participants reported improved academic achievement for all students including reluctant learners. Students, teachers, and the administrator reported greater participation in the art integrated activities. Participants perceived a need for further training for teachers and administrators for greater success.

  10. Double entry bookkeeping vs single entry bookkeeping

    Directory of Open Access Journals (Sweden)

    Ileana Andreica


    Full Text Available Abstract: A financial management eficiently begin, primarily, with an accounting record kept in the best possible conditions, this being conditioned on the adoption of a uniform forms, rational, clear and simple accounting. Throughout history, there have been known two forms of accounting: the simple and double entry. Romanian society after 1990 underwent a substantial change in social structure, the sector on which put a great emphasis being private, that of small manufacturers, peddler, freelance, who work independently and authorized or as associative form (family enterprises, various associations (owners, tenants, etc., liberal professions, etc.. They are obliged to keep a simple bookkeeping, because they have no juridical personality. Companies with legal personality are required to keep double entry bookkeeping; therefore, knowledge and border demarcation between the two forms of organisation of accounting is an essential. The material used for this work is mainly represented by the financial and accounting documents, by the analysis of the economic, by legislative updated sources, and as the method was used the comparison method, using hypothetical data, in case of an authorized individual and a legal entity. Based on the chosen material, an authorized individual (who perform single entry accounting system and a juridical entity (who perform double entry accounting system were selected comparative case studies, using hypothetical data, were analysed advantages and disadvantages in term of fiscal, if using two accounting systems, then were highlighted some conclusion that result.

  11. Entry Skills for BSNs. (United States)

    Stull, Mary K.


    Describes the Continuing Education for Consensus on Entry Skills project, designed to bring the expectations of nursing service and nursing education closer on entry-level competencies of new baccalaureate graduates. Discusses teaching and collaboration skills, planning and evaluation of patient care skills, interpersonal relations/communication…

  12. The response of teachers to new subject areas in a national science curriculum: The case of the earth science component (United States)

    King, Chris


    The National Curriculum for Science (NCS) introduced to schools in England and Wales in 1989 contained an earth science component that was new to many secondary science teachers. Ten years after this introduction, a survey was undertaken to test teacher perception of the effectiveness of their teaching in this subject area that was new to them, and to identify factors that might affect this effectiveness. The information gained has been used in reviewing possible curriculum changes and in developing professional development strategies that would improve the effectiveness of NCS earth science teaching. The data collected from science teachers who are currently teaching this earth science component revealed that their background knowledge of earth science from their own education was generally poor, even though most of them considered their knowledge to be moderate. The teachers indicated that the achievement of their pupils in earth science is moderate, while reports on national testing show it is poor. They reported that their main sources of earth science knowledge and understanding were science textbooks written for 11- to 16-year-old pupils (with their small earth science content of variable quality) and science colleagues (who often have poor earth science backgrounds too). Most teachers indicated that they needed more support in this area. Overall, the data indicated that while teachers consider their teaching in this area to be moderate, other evidence suggests it is poor. If this situation is not to continue it should be addressed. In the longer term the emphasis on the earth science content of the National Science Curriculum could be changed (either enhanced or reduced) within larger scale curriculum changes. Until such curriculum change takes place, effective methods of professional development should be instituted so that teachers have a much improved basis on which to build their earth science teaching. Similar measures would be necessary in other

  13. The Measurement of Relevance Amount of Documents That By Using of Google cross-language retrieval About Agriculture Subject Area are Retrieved

    Directory of Open Access Journals (Sweden)

    Fatemeh Jamshidi Ghahfarokhi


    Full Text Available In this study, the relevance amount of documents has been investigated by using google cross-language retrieval tools about a agriculture subject area in cross-language retrieval form, are retrieved. For this purpose, by using Persian journals articles that have had English abstracts, Persian phrases and subject terms with their English equivalent were extracted. In three class us, thirty number of phrases and subject terms of agriculture area were extracted: First class, subject phrases that only in agriculture are used; Secondary, agriculture subject terms that in other fields are used too; Third class, agriculture subject terms that out of this field are considered as public term. Then by these phrases and terms, documents were searched, and relevance amount of search results are investigated. Results of study showed that google cross-language retrieval tools for two classes of phrases and terms, in cross-language retrieval of relevance document about agriculture subject area, aren`t succeed: one class, agriculture subject terms that in other fields are used too. other class, agriculture subject terms that out of agriculture field are considered as public term. Google cross-language retrieval tools about subject phrase and terms that only in agriculture field are used, are performance rather desirable than other two class of phrase and terms

  14. Cytogenetic analysis chromosomal status of subjects from the regions in the vicinity of uranium-contaminated areas

    Energy Technology Data Exchange (ETDEWEB)

    Jovicic, D.; Milacie, S.; Kovacevic, R.; Petrovic, I.


    The past application of nuclear technology has brought about free emission of numerous Due to the military application of the depleted uranium (DU) in our country, the problem of its radioactivity and hemo toxicity if actualized. Likewise every heavy metal, its is highly toxic and, in addition to it, also radioactive: Interaction of the water-soluble uranium forms with soil is an important effect. In this way, it penetrates into food chain and endangers human health. The study was aimed at determining possible karyotype genotoxic effects in individuals from the regions close to the contaminated areas. Biological dosimetry was performed using modified Moorthead's micromethod. Our studies included the targeted group of 29 patients from the affected regions. The subjects were averagely aged 39.5{+-}2.8 years. Average age of the control group (k), unexposed to the effects of the known genotoxic agents comprising 22 individuals was 28.3{+-}1.2 years. The presented data evidenced that increased incidence of the chromosomal aberrations was found in 6 subjects,accounting for 20.6%. Dicentric type changes were evidence, as well ring chromosomes and eccentric fragments, which are, at the same time the most frequent aberrations. The changes are considered reparable aberrations accounting for 2-3% in metaphases of the unexposed individuals. Statistical data processing evidenced significant difference (p<0.005) between structural chromosomal aberrations in the studied and control groups, as well as in the number of chromatid aberrations (p<0.05).Based on the obtained data it may be concluded that human karyotype changes were present in the studied group, resulting from interaction of ionizing irradiation and other genotoxic agents, with possibility of potent synergistic effects. It is necessary to stress the importance of further monitoring and control of the general population health, particularly due to possible late genetic effects that may affect future generations

  15. The Measurement of Relevance Amount of Documents That By Using of Google cross-language retrieval About Agriculture Subject Area are Retrieved

    National Research Council Canada - National Science Library

    Fatemeh Jamshidi Ghahfarokhi


    In this study, the relevance amount of documents has been investigated by using google cross-language retrieval tools about a agriculture subject area in cross-language retrieval form, are retrieved...

  16. [Psychosocial stressors, sense of community, and subjective wellbeing in children and adolescents in urban and rural areas in Northeast Brazil]. (United States)

    Abreu, Desirée Pereira de; Viñas, Ferran; Casas, Ferran; Montserrat, Carme; González-Carrasco, Mònica; Alcantara, Stefania Carneiro de


    The study's overall objective was to investigate the relationship between psychosocial stressors, sense of community, and subjective wellbeing in urban and rural schoolchildren in Northeast Brazil, focusing on differences according to territorial context. The sample consisted of 757 participants, 495 from urban schools and 262 from rural schools, enrolled in the 6th and 7th grades (9 to 18 years of age) in 21 municipal and state public schools, of which 13 urban and 8 rural, in 7 municipalities (counties) in Ceará State, Brazil. The study instruments were inventory of stressful events, scale of life satisfaction for students, index of sense of community, and satisfaction indices by life domains (family, material goods, relations, neighborhood/zone, health, time, school, and personal). The results indicate that socioeconomically underprivileged public schoolchildren from urban areas are more exposed to daily stress and score lower on satisfaction in specific domains of life and on sense of community. This latter is an important indicator for evaluating wellbeing in this young population.

  17. Border Crossing Entry Data (United States)

    Department of Transportation — The Bureau of Transportation Statistics (BTS) Border Crossing/Entry Data provides summary statistics for inbound crossings at the U.S.-Canadian and the U.S.-Mexican...

  18. Fragmentation and ablation during entry

    Energy Technology Data Exchange (ETDEWEB)

    Canavan, G.H.


    This note discusses objects that both fragment and ablate during entry, using the results of previous reports to describe the velocity, pressure, and fragmentation of entering objects. It shows that the mechanisms used there to describe the breakup of non-ablating objects during deceleration remain valid for most ablating objects. It treats coupled fragmentation and ablation during entry, building on earlier models that separately discuss the entry of objects that are hard, whose high heat of ablation permits little erosion, and those who are strong whose strength prevents fragmentation, which are discussed in ``Radiation from Hard Objects,`` ``Deceleration and Radiation of Strong, Hard, Asteroids During Atmospheric Impact,`` and ``Meteor Signature Interpretation.`` This note provides a more detailed treatment of the further breakup and separation of fragments during descent. It replaces the constraint on mass per unit area used earlier to determine the altitude and magnitude of peak power radiation with a detailed analytic solution of deceleration. Model predictions are shown to be in agreement with the key features of numerical calculations of deceleration. The model equations are solved for the altitudes of maximum radiation, which agree with numerical integrations. The model is inverted analytically to infer object size and speed from measurements of peak power and altitude to provide a complete model for the approximate inversion of meteor data.

  19. Thinking and Reading for Entry Level Workers. (United States)

    Allentown Literacy Council, PA.

    A pilot project demonstrated that cooperative training programs are effective and cost efficient for small businesses. Common entry-level reading and thinking tasks were identified in a variety of occupational areas. Five growing occupational areas were identified: industrial/machine operator; health care; food preparation; hotel/hospitality; and…

  20. 19 CFR 151.64 - Extra copy of entry summary. (United States)


    ... TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.64 Extra copy of entry summary. One extra copy of the entry summary covering wool or hair subject to duty at a rate per clean kilogram shall be filed in addition to the copies otherwise required. ...

  1. 19 CFR 151.63 - Information on entry summary. (United States)


    ... THE TREASURY (CONTINUED) EXAMINATION, SAMPLING, AND TESTING OF MERCHANDISE Wool and Hair § 151.63 Information on entry summary. Each entry summary covering wool or hair subject to duty at a rate per clean... estimated or actual net weight of the wool or hair in its condition as imported, its total estimated clean...

  2. Viral Entry into Cells (United States)

    D'Orsogna, Maria R.


    Successful viral infection of a healthy cell requires complex host-pathogen interactions. In this talk we focus on the dynamics specific to the HIV virus entering a eucaryotic cell. We model viral entry as a stochastic engagement of receptors and coreceptors on the cell surface. We also consider the transport of virus material to the cell nucleus by coupling microtubular motion to the concurrent biochemical transformations that render the viral material competent for nuclear entry. We discuss both mathematical and biological consequences of our model, such as the formulation of an effective integrodifferential boundary condition embodying a memory kernel and optimal timing in maximizing viral probabilities.

  3. Advanced Restricted Area Entry Control System (Araecs) (United States)


    Table 19. Technology Readiness Level Maturity Assessment 2. Biometric Modalities a. Iris Recognition (1) Overview. The Iris is the colored part of derived from measurement of a part of a person’s anatomy. Examples of physiological biometrics include fingerprint, hand, face, iris and retina. A... biometrics that can be used with a smart identification card include: fingerprint, hand geometry, facial recognition, iris and retina scan, and voice and

  4. Lobbying on entry

    NARCIS (Netherlands)

    Perotti, E.C.; Volpin, P.


    We develop a model of endogenous lobby formation in which wealth inequality and political accountability undermine entry and financial development. Incumbents seek a low level of effective investor protection to prevent potential entrants from raising capital. They succeed because they can promise

  5. MEG reveals a fast pathway from somatosensory cortex to occipital areas via posterior parietal cortex in a blind subject

    DEFF Research Database (Denmark)

    Ioannides, Andreas A; Liu, Lichan; Poghosyan, Vahe


    magnetoencephalography (MEG) data recorded from one congenitally blind and two sighted subjects after stimulation of the left and right median nerves at three intensities: below sensory threshold, above sensory threshold and above motor threshold; the last sufficient to produce thumb twitching. We identified...... reproducible brain responses in the primary somatosensory (S1) and motor (M1) cortices at around 20 ms post-stimulus, which were very similar in sighted and blind subjects. Time-frequency analysis revealed strong 45-70 Hz activity at latencies of 20-50 ms in S1 and M1, and posterior parietal cortex Brodmann...... of information through this pathway occurred in stages characterized by convergence of activations into specific cortical regions. In sighted subjects, no linked activity was found that led from the somatosensory to the visual cortex through any of the studied brain regions. These results provide the first...

  6. Reproducibility of fat area measurements in young, non-obese subjects by computerized analysis of magnetic resonance images

    NARCIS (Netherlands)

    Elbers, J.M.; Haumann, G.; Asscheman, H.; Seidell, J C; Gooren, Louis J G


    OBJECTIVE: To assess reproducibility, expressed as both inter-observer variability and intra-observer variability, of fat area measurements on images obtained by magnetic resonance (MR); to compare variability between fat area measurements, calculated from a single image per body region and from the

  7. Parallels between Objective Indicators and Subjective Perceptions of Quality of Life: A Study of Metropolitan and County Areas in Taiwan (United States)

    Liao, Pei-shan


    This study explores the consistency between objective indicators and subjective perceptions of quality of life in a ranking of survey data for cities and counties in Taiwan. Data used for analysis included the Statistical Yearbook of Hsiens and Municipalities and the Survey on Living Conditions of Citizens in Taiwan, both given for the year 2000.…

  8. Subjectivity in Education and Health: Research Notes on School Learning Area and Physical Education in Mental Health (United States)

    Bezerra, Marilia; da Costa, Jonatas Maia


    This paper presents the results of two studies researching the theory of subjectivity from a cultural-historical perspective. The studies are situated in the fields of education and health and are conducted using Qualitative Epistemology. The first study discusses the pathological movement problems of learning disabilities in Brazilian schools and…

  9. Atmospheric Entry Experiments at IRS (United States)

    Auweter-Kurtz, M.; Endlich, P.; Herdrich, G.; Kurtz, H.; Laux, T.; Löhle, S.; Nazina, N.; Pidan, S.


    Entering the atmosphere of celestial bodies, spacecrafts encounter gases at velocities of several km/s, thereby being subjected to great heat loads. The thermal protection systems and the environment (plasma) have to be investigated by means of computational and ground facility based simulations. For more than a decade, plasma wind tunnels at IRS have been used for the investigation of TPS materials. Nevertheless, ground tests and computer simulations cannot re- place space flights completely. Particularly, entry mission phases encounter challenging problems, such as hypersonic aerothermodynamics. Concerning the TPS, radiation-cooled materials used for reuseable spacecrafts and ablator tech- nologies are of importance. Besides the mentioned technologies, there is the goal to manage guidance navigation, con- trol, landing technology and inflatable technologies such as ballutes that aim to keep vehicles in the atmosphere without landing. The requirement to save mass and energy for planned interplanetary missions such as Mars Society Balloon Mission, Mars Sample Return Mission, Mars Express or Venus Sample Return mission led to the need for manoeuvres like aerocapture, aero-breaking and hyperbolic entries. All three are characterized by very high kinetic vehicle energies to be dissipated by the manoeuvre. In this field flight data are rare. The importance of these manoeuvres and the need to increase the knowledge of required TPS designs and behavior during such mission phases point out the need of flight experiments. As result of the experience within the plasma diagnostic tool development and the plasma wind tunnel data base, flight experiments like the PYrometric RE-entry EXperiment PYREX were developed, fully qualified and successfully flown. Flight experiments such as the entry spectrometer RESPECT and PYREX on HOPE-X are in the conceptual phase. To increase knowledge in the scope of atmospheric manoeuvres and entries, data bases have to be created combining both

  10. [Left ventricular hypertrophy in black African subjects with artery hypertension: Results of a cross-sectional survey conducted in semi-rural area in Senegal]. (United States)

    Mbaye, A; Dodo, B; Ngaïde, A A; Sy, N F; Babaka, K; Mingou, J S; Faye, M; Niang, K; Sarr, S A; Dioum, M; Bodian, M; Ndiaye, M B; Kane, A D; Ndour-Mbaye, M; Diao, M; Diack, B; Kane, M; Diagne-Sow, D; Thiaw, I; Kane, A


    To assess the prevalence of left ventricular hypertrophy according to electrocardiographic and echocardiographic criteria among hypertensive patients living in semi-rural Senegalese area. According to the World Health Organization STEPSwise approach, we conducted, in November 2012, a cross-sectional and exhaustive study in the population aged at least 35 years old and living for at least six months in the semi-rural area of Guéoul. We researched electrocardiographic and echocardiographic left ventricular hypertrophy in hypertensive subjects. Data were analyzed with SPSS 18.0 software version. The significance level was agreed for a value of P<0.05. We examined 1411 subjects aged on average of 48.5±12.7 years. In total, 654 subjects were hypertensive and screening of left ventricular hypertrophy (LVH) was effective in 515 of them. According to Sokolow-Lyon index, 86 subjects (16.7%) presented electrocardiographic LVH, more frequently in men (P=0.002). According to Cornell index and Cornell product, LVH was founded respectively in 66 (12.8%) and 52 subjects (10.1%), more frequently in female (P=0.0001; P=0.004). It was more common in grade 3 of hypertension however criteria. In echocardiography, prevalence of LVH was 2.2% (13 cases) according to the left ventricular mass, 9.3% (48 cases) according to the left ventricular mass indexed to body surface area and 8.2% (42 cases) according to the left ventricular mass indexed to height 2.7 . LVH was significantly correlated with the electrocardiographic LVH according to Sokolow-Lyon index (P<0.0001) and the grade 3 of hypertension (P=0.003). Although rare in hypertensive Senegalese living in semi-rural area, left ventricular hypertrophy is correlated with severity of grade of hypertension. Screening by electrocardiogram will allow better follow-up of these hypertensive subjects. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  11. Deployable Entry-system Project (United States)

    National Aeronautics and Space Administration — The Deployable Entry-system ProjecT (ADEPT) will develop requirements for the ADEPT flight test.  Prior entry systems used high mass thermal protection...

  12. Entry Decision and Pricing Policies


    Sílvia Jorge; Cesaltina Pires


    We extend the analysis of the impact of firms' pricing policies upon entry to a framework where price competition and differentiated products are present. We consider a model where an incumbent serves two distinct and independent geographical markets and an entrant may enter in one of the markets. Entry under discriminatory pricing is more likely than under uniform pricing when entry is profitable under discriminatory pricing but unprofitable under uniform pricing. Our results show entry unde...

  13. The perceptions of teachers and principals toward providing additional compensation to teachers in high-need subject areas (United States)

    Longing, Jeffrey Lucian

    The purpose of this study was to determine possible differences in the perceptions of teachers teaching in high-need areas (i.e., math, science, special education, etc.) and teachers not teaching in high-need areas, (i.e., business education, physical education, etc.) as defined by the states of Arkansas and Louisiana, regarding higher compensation for high-need teachers. In addition, possible perception differences among principals and teachers were determined. The independent variables consisted of gender, position held, years of certified experience, and certification areas. The dependent variable was the perceptions of the participants on providing higher compensation for high-need teachers in order to attract and retain them. The data for all variables were collected using the Teacher Compensation Survey. The sample for this study was limited to teachers, grades 9 through 12, and principals of public high schools in south Arkansas and north Louisiana. Forty-four school districts in south Arkansas (Arkansas Department of Education, 2008a) and north Louisiana (Louisiana Department of Education, 2008a) met the criteria for this study. Twenty-two superintendents gave permission for their districts to participate in the research. A sample of 849 teachers and 38 principals were identified in these districts. Surveys were returned from 350 teachers, creating a 41% response rate. When the 31 principals that returned surveys were added to the total population, the response rate increased to 43% with 381 of the 887 surveyed responding. However, 42 of the teachers and two of the principals skipped some of the questions on the survey and were not included in the study. The researcher used a One-Way ANOVA and independent t-tests to determine the presence of statistical differences at the .05 level. The data showed that most math and science teachers agreed that high-need teachers should be compensated at a higher rate than teachers not teaching in high-need areas. The data

  14. Moderate-to-vigorous physical activity in individuals with psoriasis: associations with body surface area and subjective disease severity. (United States)

    Wilson, P B


    Psoriasis is associated with serious comorbidities such as cardiovascular disease, type 2 diabetes, and metabolic syndrome. These comorbidities are related to low physical activity in the general population. Limited research has evaluated physical activity in psoriasis, and thus, the purpose of this investigation was to compare physical activity between individuals with and without psoriasis as well as explore the associations between measures of psoriasis severity and physical activity. Cross-sectional study using data from the 2003-2006 National Health and Nutrition Examination Survey. Self-reported psoriasis diagnosis and psoriasis severity were regressed on moderate/vigorous physical activity, as measured objectively by accelerometers. Measures of psoriasis severity included rating of psoriasis as a problem in life and body surface area involvement. A total of 4316 individuals had data on psoriasis, moderate/vigorous physical activity, and relevant covariates, with 3.6% (population weighted) of participants (N.=117) reporting a diagnosis of psoriasis. A psoriasis diagnosis was not associated with moderate/vigorous physical activity, and furthermore, body surface area involvement was not associated with moderate/vigorous physical activity among participants with psoriasis. However, every tertile increase in psoriasis as a problem in life was associated with 28% less moderate/vigorous physical activity, which remained significant after adjusting for covariates and removing outliers. While a diagnosis of psoriasis and body surface area involvement do not appear to be associated with less moderate/vigorous physical activity, individuals that rate their psoriasis to be a large problem engage in less moderate/vigorous physical activity.

  15. Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil

    Directory of Open Access Journals (Sweden)

    Juan Camilo Sánchez-Arcila


    Full Text Available In Brazil, malaria is prevalent in the Amazon region and these regions coincide with high prevalence of intestinal parasites but few studies explore the interaction between malaria and other parasites. Therefore, the present study evaluates changes in cytokine, chemokine, C-reactive protein, and nitric oxide (NO concentrations in 264 individuals, comparing plasma from infected individuals with concurrent malaria and intestinal parasites to individuals with either malaria infection alone and uninfected. In the studied population 24% of the individuals were infected with Plasmodium and 18% coinfected with intestinal parasites. Protozoan parasites comprised the bulk of the intestinal parasites infections and subjects infected with intestinal parasites were more likely to have malaria. The use of principal component analysis and cluster analysis associated increased levels of IL-6, TNF-α, IL-10, and CRP and low levels of IL-17A predominantly with individuals with malaria alone and coinfected individuals. In contrast, low levels of almost all inflammatory mediators were associated predominantly with individuals uninfected while increased levels of IL-17A were associated predominantly with individuals with intestinal parasites only. In conclusion, our data suggest that, in our population, the infection with intestinal parasites (mainly protozoan does not modify the pattern of cytokine production in individuals infected with P. falciparum and P. vivax.

  16. Concentration and correlations of perfluoroalkyl substances in whole blood among subjects from three different geographical areas in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Chon Rae; Lam, Nguyen Hoang [College of Fisheries and Ocean Sciences, Chonnam National University, Yeosu 550-749 (Korea, Republic of); Cho, Byung Mann [Department of Preventive Medicine and Occupational Medicine, School of Medicine, Pusan National University, Yangsan 626-770 (Korea, Republic of); Kannan, Kurunthachalam [Wadsworth Center, New York State Department of Health and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Empire State Plaza PO Box 509, Albany, NY 12201-0509 (United States); Cho, Hyeon Seo, E-mail: [College of Fisheries and Ocean Sciences, Chonnam National University, Yeosu 550-749 (Korea, Republic of)


    blood were found in Korea. • Gender was found to influence the concentrations of PFOA, PFNA, PFHxS and PFOSA. • Significant positive associations between PFAS levels and age of subjects were found. • Occupation was a determinant for PFNA and PFHxS concentrations.

  17. Paralympic Games sport entries mamual



    This manual is designed to provide National Paralympic Committees (NPCs) with the Paralympic Sport Entries process, relevant policies, and instructions for completing the online registration for athletes participating in the Sochi 2014 Paralympic Winter Games and to assist NPCs in using the online Sport Entries and Qualification (ePEQ) system to complete the entries of their athletes to the Sochi 2014 Paralympic Winter Games.

  18. Advertising and generic market entry. (United States)

    Königbauer, Ingrid


    The effect of purely persuasive advertising on generic market entry and social welfare is analysed. An incumbent has the possibility to invest in advertising which affects the prescribing physician's perceived relative qualities of the brand-name and the generic version of the drug. Advertising creates product differentiation and can induce generic market entry which is deterred without differentiation due to strong Bertrand competition. However, over-investment in advertising can deter generic market entry under certain conditions and reduces welfare as compared to accommodated market entry.

  19. Effect of toe-spread-out exercise on hallux valgus angle and cross-sectional area of abductor hallucis muscle in subjects with hallux valgus. (United States)

    Kim, Moon-Hwan; Yi, Chung-Hwi; Weon, Jong-Hyuck; Cynn, Heon-Seock; Jung, Do-Young; Kwon, Oh-Yun


    [Purpose] This study investigated whether the toe-spread-out exercise affects the hallux valgus angle, the cross-sectional area of the abductor hallucis muscle, and the hallux valgus angle during active abduction. [Subjects and Methods] Twenty-four subjects with hallux valgus were randomly assigned to orthosis and orthosis plus toe-spread-out exercise groups. The orthosis group wore the orthosis for 8 weeks, while the orthosis plus toe-spread-out group also performed the toe-spread-out exercise. The hallux valgus angle, the cross-sectional area of the abductor hallucis muscle, and the hallux valgus angle during active abduction were measured initially and after 8 weeks by radiography and ultrasonography. [Results] While there were no significant changes in the three parameters in the orthosis group, there were significant differences in the orthosis plus toe-spread-out exercise group after 8 weeks. In addition there were significant differences in the three measures between the two groups. [Conclusion] The toe-spread-out exercise reduces the hallux valgus angle and hallux valgus angle during active abduction, and increases the cross-sectional area of the abductor hallucis muscle. The toe-spread-out exercise is recommended for patients with mild to moderate hallux valgus.

  20. An analysis of subject areas and country participation for all health-related projects in the EU's FP5 and FP6 programmes. (United States)

    Galsworthy, Michael J; Irwin, Rachel; Charlesworth, Kate; Ernst, Kelly; Hristovski, Dimitar; Wismar, Matthias; McKee, Martin


    Previous analyses concerning health components of European Union (EU)-funded research have shown low project participation levels of the 12 newest member states (EU-12). Additionally, there has been a lack of subject-area analysis. In the Health Research for Europe project, we screened all projects of the EU's Framework Programmes for research FP5 and FP6 (1998-2006) to identify health research projects and describe participation by country and subject area. FP5 and FP6 project databases were acquired and screened by coders to identify health-related projects, which were then categorized according to the 47 divisions of the EU Health Portal (N = 2728 projects) plus an extra group of 'basic/biotech' projects (N = 1743). Country participation and coordination rates for projects were also analyzed. Approximately 20% of the 26 946 projects (value €29.2bn) were health-related (N = 4756. Value €6.04bn). Within the health categories, the largest expenditures were cancer (11.9%), 'other' (i.e. not mental health or cardiovascular) non-communicable diseases (9.5%) and food safety (9.4%). One hundred thirty-two countries participated in these projects. Of the 27 EU countries (and five partner countries), north-western and Nordic states acquired more projects per capita. The UK led coordination with > 20% of projects. EU-12 countries were generally under-represented for participation and coordination. Combining our findings with the associated literature, we comment on drivers determining distribution of participation and funds across countries and subject areas. Additionally, we discuss changes needed in the core EU projects database to provide greater transparency, data exploitation and return on investment in health research. © The Author 2013. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.

  1. Study Results on Knowledge Requirements for Entry-Level Airport Operations and Management Personnel (United States)

    Quilty, Stephen M.


    This paper identifies important topical knowledge areas required of individuals employed in airport operations and management positions. A total of 116 airport managers and airfield operations personnel responded to a survey that sought to identify the importance of various subject matter for entry level airport operations personnel. The results from this study add to the body of research on aviation management curriculum development and can be used to better develop university curriculum and supplemental training focused on airport management and operations. Recommendations are made for specialized airport courses within aviation management programs. Further, this study identifies for job seekers or individuals employed in entry level positions those knowledge requirements deemed important by airport managers and operations personnel at different sized airports.

  2. Tactile Data Entry for Extravehicular Activity (United States)

    Adams, Richard J.; Olowin, Aaron B.; Hannaford, Blake; Sands, O Scott


    In the task-saturated environment of extravehicular activity (EVA), an astronaut's ability to leverage suit-integrated information systems is limited by a lack of options for data entry. In particular, bulky gloves inhibit the ability to interact with standard computing interfaces such as a mouse or keyboard. This paper presents the results of a preliminary investigation into a system that permits the space suit gloves themselves to be used as data entry devices. Hand motion tracking is combined with simple finger gesture recognition to enable use of a virtual keyboard, while tactile feedback provides touch-based context to the graphical user interface (GUI) and positive confirmation of keystroke events. In human subject trials, conducted with twenty participants using a prototype system, participants entered text significantly faster with tactile feedback than without (p = 0.02). The results support incorporation of vibrotactile information in a future system that will enable full touch typing and general mouse interactions using instrumented EVA gloves.

  3. Keyboard data entry use among osteopathic medical students and residents. (United States)

    Helstrom, Julia M; Langenau, Erik E; Sandella, Jeanne M; Mote, Beth L


    Candidates taking the Comprehensive Osteopathic Medical Licensing Examination-USA Level 2-Performance Evaluation (COMLEX-USA Level 2-PE) are currently evaluated on their ability to document clinical findings using a handwritten postencounter note. However, keyboard data entry is increasingly used for medical documentation. To determine the use and perception of keyboard data entry among osteopathic medical students and residents in educational and clinical settings. A Web-based survey regarding frequency of and preference for keyboard data entry was distributed to 9801 osteopathic medical students, 17,268 osteopathic residents, and 34 clinical deans of colleges of osteopathic medicine (COMs). In addition, 31 COMs' clinical skills center directors were contacted to participate in a telephone survey about the use of keyboard data entry in their centers. A total of 1711 students, 1198 residents, 14 clinical deans, and 17 clinical skills center directors responded to the surveys. The majority of students (872 [51%]) reported using electronic keyboard data entry at their COM's clinical skills center for postencounter notes. Among respondents, 379 students (23%), 77 residents (9%), and 1 clinical dean reported that electronic keyboard data entry is never or rarely used during clinical rotations. Most trainees (1592 students [93%], 864 residents [94%]) reported that they were either comfortable or very comfortable with typing. Given the option of recording methods for SOAP (subjective, objective, assessment, plan) note findings on the COMLEX-USA Level 2-PE, 7 clinical deans were unsure of their students' preferences, while the remaining favored keyboard data entry (5) over handwriting (2). The majority of student and resident respondents would choose keyboard data entry (1009 [60%] and 511 [55%], respectively). Osteopathic medical students and residents are comfortable with typing; they are exposed to and would prefer using an electronic form of entry for medical

  4. [Nicotine dependence, smoking-related attitude, and subjective norms across the stages of change for smoking cessation among adults smokers in a rural area]. (United States)

    Kim, Young Hee; Seo, Nam Sook; Kang, Hae Young


    The purpose of this study was to identify nicotine dependence, smoking-related attitude, and subjective norms across the stages of change for smoking cessation among adult smokers in a rural area. The subjects were 276 current smokers (male=243, female=33). There were 3 stages of change for smoking cessation: pre-contemplation, contemplation, and preparation stage. Data was collected by an interview or self-reporting from February 12th to March 5th 2004, and analyzed with frequency, percentage, chi- square-test, Fisher's exact probability test, ANOVA, and Scheffe test using the SPSS-PC program. According to the stages of change, 114(41.3%) current smokers were in pre-contemplation, 110(39.9%) in contemplation, and 52(18.8%) in the preparation stage. There was a higher percentage of males than females (chi- square=8.99, p=.011) in the preparation stage. The mean score of the smoking-related attitude (F=7.43, p=.001) and subjective norm(F=27.41, p=.001) were both lowest in the pre-contemplation stage and increased positively during the stages of change for smoking cessation. Based on these findings, the authors recommend that community-based smoking cessation programs should be developed by considering the intention or motives of current smokers and should be initiated in the preparation stage and primarily for male groups.

  5. HIV: cell binding and entry

    National Research Council Canada - National Science Library

    Wilen, Craig B; Tilton, John C; Doms, Robert W


    The first step of the human immunodeficiency virus (HIV) replication cycle-binding and entry into the host cell-plays a major role in determining viral tropism and the ability of HIV to degrade the human immune system...

  6. Tactile Data Entry System Project (United States)

    National Aeronautics and Space Administration — Building on our successful Phase I Tactile Data Entry program, Barron Associates proposes development of a Glove-Enabled Computer Operations (GECO) system to permit...

  7. Iodine distribution in natural waters of different chemical composition in relation to water-bearing soils and rocks and water fractions in areas subjected to radioiodine contamination (United States)

    Kolmykova, Liudmila; Korobova, Elena


    Iodine is an essential microelement required for normal functioning of thyroid gland. Natural deficiency of stable iodine is compensated by its active intake by thyroid and provokes its higher irradiation in case of radiation accidents and contamination of the environment by radioiodine isotopes. The bioavailability of both stable and radioactive iodine and the specificity of its uptake by living organisms largely depends on geochemical parameters of the environment related to natural conditions of water migration. The goal of the study was to investigate spatial distribution of iodine in natural water of different chemical composition in relation to typical water-bearing soils and rocks and water fractions in Bryansk areas subjected to radioiodine contamination after the Chernobyl accident and to evaluate contribution of this factor to the occurrence of endemic thyroid diseases among local population inhabiting geochemically different areas of fluvioglacial and loess-like sedimentary rocks. The highest content of iodine (Me=13.3 µg/l) was observed in surface water of landscapes with H-Ca, Ca and H-Ca-Fe classes of water migration. The lowest microelement level (Me=5.25 µg/l) was noted in groundwater of landscapes with H, H-Fe classes of water migration in areas of Paleogene water bearing rocks. Regardless of the type of source and class of water migration up to 90% of the total content of iodide is present in the fraction membrane filtration). Up to 50% of iodine pass to solution containing particles water in areas of loess-like sedimentary rocks hosts the highest levels of iodine where its associated with calcium mineral aquatic complexes and the suspended particles. The obtained data is believed to be useful in explanation of mobility and intake of iodine and its radioactive analogues by rural population living in different geochemical conditions and using local drinking waters. The data should be accounted of in planning prophylactics of endemic diseases and

  8. Educational role of art history as a school subject area in programmes of formal education in Slovenia: the aspect of vzgoja, according to general European guidelines

    Directory of Open Access Journals (Sweden)

    Marjana Dolšina


    Full Text Available Programmes of formal education establish a systematic transfer of knowledge as well as universal values from one generation to another. By that, they ensure the survival of social structures, prevent radical disruptions in their continuity, and serve as basis for general development of a society. Their content and didactic arrangements include interweaving of two basic aspects: the cognitive one and the one related to vzgoja (i.e. upbringing, moral/value education etc.. The latter aims to achieve the ideals of a tolerant, just and lifelong learning society, but seems to be facing increasing challenges, mainly emerging from neoliberal capitalist mentality. Art history as a school subject area in elementary and secondary education may provide an insight beneath the surface of historical events. Thus, it helps develop a critical view towards them and consequently towards the present real-life situations, which contributes to ascending the taxonomic scale of conative educational goals.

  9. [Subjective Workload, Job Satisfaction, and Work-Life-Balance of Physicians and Nurses in a Municipal Hospital in a Rural Area Compared to an Urban University Hospital]. (United States)

    Körber, Michael; Schmid, Klaus; Drexler, Hans; Kiesel, Johannes


    Medical and nursing shortages in rural areas represent a current serious public health problem. The healthcare of the rural population is at risk. This study compares perceived workload, job satisfaction and work-life balance of physicians and nurses at a clinic in a rural area with two clinics of a University hospital. Physicians and nurses were interviewed anonymously with a standardized questionnaire (paper and pencil), including questions on job satisfaction, subjective workload and work-life balance. The response rate was almost 50% in the University hospital as well as in the municipal hospital. 32 physicians and 54 nurses from the University hospital and 18 physicians and 137 nurses from the municipal hospital participated in the survey. Nurses at the University hospital assessed the organization of the daily routine with 94.1% as better than those at the municipal hospital (82.4%, p=0.03). Physicians at the University hospital were able to better implement acquired knowledge at a University clinic with 87.5% than their counterparts at the municipal hospital (55.5%, p=0.02). In contrast to their colleagues at the municipal hospital, only 50% of the physicians at the University hospital subjectively considered their workload as just right (83.3% municipal, p=0.02). 96.9% of the physicians at the University hospital were "daily" or "several times a week" under time pressure (municipal 50%, pwork and family life (62.9% University hospital, 72.8% Municipal hospital). In contrast, only 20% of the physicians at the University Hospital but 42.9% of the physicians of the municipal hospital had sufficient opportunities to balance workload and family (p=0.13). The return rate of almost 50% can be described as good. Due to the small number of physicians, especially from the municipal hospital, it can be assumed that some interesting differences could not be detected. There were only slight differences between the nurses from the two hospitals. In contrast, subjective

  10. Physics-Based Modeling of Meteor Entry and Breakup (United States)

    Prabhu, Dinesh K.; Agrawal, Parul; Allen, Gary A., Jr.; Bauschlicher, Charles W., Jr.; Brandis, Aaron M.; Chen, Yih-Kang; Jaffe, Richard L.; Palmer, Grant E.; Saunders, David A.; Stern, Eric C.; hide


    spherical geometries of diameters ranging from 1 to 100 m for an entry velocity of 20 kms and stagnation pressures ranging from 1 to 100 atm; (ii) the influence of shape and departure of heating environment predictions from those for a simple spherical geometry; (iii) assessment of thermal response models for silica subject to intense radiation; and (iv) results for porosity-driven gross fragmentation of meteors, idealized as a collection of smaller objects. Lessons learned from these simulations will be used to help understand the Chelyabinsk meteor entry up to its first point of fragmentation.

  11. Autonomous gliding entry guidance with

    Directory of Open Access Journals (Sweden)

    Guo Jie


    Full Text Available This paper presents a novel three-dimensional autonomous entry guidance for relatively high lift-to-drag ratio vehicles satisfying geographic constraints and other path constraints. The guidance is composed of onboard trajectory planning and robust trajectory tracking. For trajectory planning, a longitudinal sub-planner is introduced to generate a feasible drag-versus-energy profile by using the interpolation between upper boundary and lower boundary of entry corridor to get the desired trajectory length. The associated magnitude of the bank angle can be specified by drag profile, while the sign of bank angle is determined by lateral sub-planner. Two-reverse mode is utilized to satisfy waypoint constraints and dynamic heading error corridor is utilized to satisfy no-fly zone constraints. The longitudinal and lateral sub-planners are iteratively employed until all of the path constraints are satisfied. For trajectory tracking, a novel tracking law based on the active disturbance rejection control is introduced. Finally, adaptability tests and Monte Carlo simulations of the entry guidance approach are performed. Results show that the proposed entry guidance approach can adapt to different entry missions and is able to make the vehicle reach the prescribed target point precisely in spite of geographic constraints.

  12. Chemical composition of drinking water as a possible environment-specific factor modifying the thyroid risk in the areas subjected to radioiodine contamination (United States)

    Kolmykova, Lyudmila; Korobova, Elena; Ryzhenko, Boris


    Water is one of the main natural agents providing chemical elements' migration in the environment and food chains. In our opinion a study of spatial variation of the essential trace elements in local drinking water is worth considering as the factor that may contribute to variation of the health risk in areas contaminated by radionuclides and radioiodine in particular. Radioiodine was proved to increase the risk of thyroid cancer among children who lived in areas contaminated during the Chernobyl accident. It was also shown that low stable iodine status of the contaminated area and population also contributed to the risk of this disease in case of radionuclide contamination. The goal of the study was to investigate chemical composition of the drinking water in rural settlements of the Bryansk oblast' subjected to radioiodine contamination and to evaluate speciation of stable I and Se on the basis of their total concentration and chemical composition of the real water samples with the help of thermodynamic modelling. Water samples were collected from different aquifers discharging at different depths (dug wells, local private bore holes and water pipes) in rural settlements located in areas with contrasting soil iodine status. Thermodynamic modelling was performed using original software (HCh code of Y.Shvarov, Moscow State University, RUSSIA) incorporating the measured pH, Corg and elements' concentration values. Performed modelling showed possibility of formation of complex CaI+ ion in aqueous phase, I sorption by goethite and transfer of Se to solid phase as FeSe in the observed pH-Eh conditions. It helped to identify environmental conditions providing high I and Se mobility and their depletion from natural waters. Both the experimental data and modeling showed that I and Se migration and deficiency in natural water is closely connected to pH, Eh conditions and the concentration of typomorphic chemical elements (Ca, Mg, Fe) defining the class of water migration

  13. How Dictionary Users Choose Senses in Bilingual Dictionary Entries ...

    African Journals Online (AJOL)

    Abstract: We use modern eye-tracking technology to scrutinize the process of sense and equivalent selection in polysemous bilingual entries. Our study subjects, intermediate and advanced Polish learners of English, consulted 26 Polish-to-English dictionary pages prompted with a sentence translation task. Throughout the ...

  14. Effects of Guidance Techniques and Initial/Entry Career Maturity ...

    African Journals Online (AJOL)

    while the fourth group was exposed to a non-specific treatment (drug abuse). The design is a 4 x 2 factorial with fixed effect consisting of initial/entry career behaviour (high & low) and treatment/control groups. Data d erived from the post treatment were subjected to 2-way analysis of variance. The results of the study show ...

  15. Visas for entry and stays in the Host States

    CERN Multimedia

    DG Unit


    1. What is a visa? A visa is an administrative document authorising nationals of countries subject to the visa requirement to transit, enter and stay in a foreign country. The numerous types of visa include in particular: a) Short-stay visas (the Schengen C-type visa), which allows their holders to enter and reside in the Schengen Area1) for a continuous or a non-continuous period not exceeding 3 months within any six-month period with effect from initial entry into the Schengen Area; b) Long-stay visas (D-type visa or national visa for the purposes of taking up employment), which are required for stays of over three months, allowing the holder to obtain a legitimation document (titre de séjour) from the Host States: A “carte de légitimation” issued by the Swiss Federal Department of Foreign Affairs; A “titre de séjour spécial” issued by the French Ministry of Foreign and European Affairs. Since 5 April 2010...

  16. Spacecraft entry into an atmosphere (United States)

    Iaroshevskii, Vasilii A.

    Problems related to the safe entry of spacecraft into the earth or other planetary atmospheres are discussed in a general manner. Attention is given to restrictions imposed on dynamical and thermal overloads, and an analysis is made of the aerodynamic characteristics of space vehicles of different types. Analytical and semianalytical methods for calculating entry trajectories are compared, and the applicability regions of approximate solutions are determined. The discussion also covers reentry trajectory optimization problems and the principal types of perturbations and navigation and control techniques.

  17. Regulation of entry into gametogenesis. (United States)

    van Werven, Folkert J; Amon, Angelika


    Gametogenesis is a fundamental aspect of sexual reproduction in eukaryotes. In the unicellular fungi Saccharomyces cerevisiae (budding yeast) and Schizosaccharomyces pombe (fission yeast), where this developmental programme has been extensively studied, entry into gametogenesis requires the convergence of multiple signals on the promoter of a master regulator. Starvation signals and cellular mating-type information promote the transcription of cell fate inducers, which in turn initiate a transcriptional cascade that propels a unique type of cell division, meiosis, and gamete morphogenesis. Here, we will provide an overview of how entry into gametogenesis is initiated in budding and fission yeast and discuss potential conserved features in the germ cell development of higher eukaryotes.

  18. Economics of entry into marriage


    Bowmaker, Simon W.


    This thesis contains three studies on the economics of entry into marriage; a life event that has been shown to have significant implications for the well-being (economic and otherwise) of men, women and their children. The first study examines the effect of family background on the timing of first marriage of 7,853 individuals born in 1970 in Great Britain. Hazard model analysis reveals that high levels of parental resources serve to delay entry into marriage for both males and femal...

  19. 9 CFR 381.208 - Poultry products offered for entry and entered to be handled and transported as domestic; entry... (United States)


    ... Cosmetic Act. (b) Poultry products entered in accordance with this subpart may, subject to the provisions... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Poultry products offered for entry and....208 Section 381.208 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF...

  20. Entry Facilitation by Environmental Groups

    NARCIS (Netherlands)

    van der Made, Allard; Schoonbeek, Lambert

    We consider a model of vertical product differentiation where consumers care about the environmental damage their consumption causes. An environmental group is capable of increasing consumers' environmental concern via a costly campaign. We show that the prospect of such a campaign can induce entry

  1. Phoebus: A Hypervelocity Entry Demonstrator (United States)

    Ferracina, L.; Marraffa, L.; Longo, J.


    ESA is today considering various missions, such as Marco Polo R and (Moon of) Mars Sample Return, requiring capsules re-entering the Earth atmosphere at speeds up to 13 km/s.To mature critical high speed re-entry technologies and consequently to speed-up the development and reduce the development cost (and cost uncertainties) for future sample return mission, an in-flight technology demonstrator, named PHOEBUS (Project for a High- speed Of Entry Ballistic multi-User System), is presently under investigation at the European Space Research and Technology Centre (ESTEC) of ESA.This paper focuses on the preliminary aerothermodynamics feasibility assessment conducted within the Concurrent Design Facility (CDF) study at ESA-ESTEC for the design of the PHOEBUS re-entry capsule starting from a parametric analysis of the entry phase to enable a preliminary design and a baseline configuration selection and concluded with non- equilibrium reacting flow computations coupled with radiation and transport simulations to estimate the heat flux experience by the TPS at few selected trajectory points.

  2. Forcing Entry into the Nucleus. (United States)

    Lomakin, Alexis; Nader, Guilherme; Piel, Matthieu


    Nuclear pore complexes tightly regulate nucleo-cytoplasmic transport, controlling the nuclear concentration of several transcription factors. In a recent issue of Cell, Elosegui-Artola et al. (2017) show that nuclear deformation modulates the nuclear entry rates of YAP/TAZ via nuclear pore stretching, clarifying how forces affect gene transcription. Copyright © 2017. Published by Elsevier Inc.

  3. Text Entry by Gazing and Smiling

    Directory of Open Access Journals (Sweden)

    Outi Tuisku


    Full Text Available Face Interface is a wearable prototype that combines the use of voluntary gaze direction and facial activations, for pointing and selecting objects on a computer screen, respectively. The aim was to investigate the functionality of the prototype for entering text. First, three on-screen keyboard layout designs were developed and tested (n=10 to find a layout that would be more suitable for text entry with the prototype than traditional QWERTY layout. The task was to enter one word ten times with each of the layouts by pointing letters with gaze and select them by smiling. Subjective ratings showed that a layout with large keys on the edge and small keys near the center of the keyboard was rated as the most enjoyable, clearest, and most functional. Second, using this layout, the aim of the second experiment (n=12 was to compare entering text with Face Interface to entering text with mouse. The results showed that text entry rate for Face Interface was 20 characters per minute (cpm and 27 cpm for the mouse. For Face Interface, keystrokes per character (KSPC value was 1.1 and minimum string distance (MSD error rate was 0.12. These values compare especially well with other similar techniques.

  4. Increasing mortality from ischaemic heart disease in China from 2004 to 2010: disproportionate rise in rural areas and elderly subjects. 438 million person-years follow-up. (United States)

    Zhang, Xiaofei; Khan, Arshad A; Haq, Ehtesham Ul; Rahim, Aadil; Hu, Dayi; Attia, John; Oldmeadow, Christopher; Ma, Xiaoyan; Ding, Rongjing; Boyle, Andrew J


    We sought to ascertain the changes in mortality from ischaemic heart disease (IHD) from 2004 to 2010 in China as the sheer size of China's population makes disease patterns relevant globally. Data on IHD mortality were obtained from the Chinese Centre for Disease Control and Prevention National Disease Surveillance Point System, which includes 161 counties and a population of over 73 million-a representative sample of over 6% of the entire population of China. Both crude and World Health Organization (WHO)-standardized IHD mortality increased, in both men and women and in both urban and rural locations, during the study period, demonstrating the effect of urbanization, economic growth, and epidemiological transition on cardiovascular health. WHO-standardized IHD mortality increased for rural males by 9.2% per year (95% CI: 6.7-11.7%; P < 0.0001), and the trend was statistically significantly higher (P = 0.0001) than in urban males by 6.4% per year (95% CI: 3-10%; P = 0.02). WHO-standardized IHD mortality rate increased for rural females by 7.0% per year (95% CI: 4.6-9.4%; P < 0.0001); this was statistically significantly higher than urban females by 4.3% per year (95% CI: 1-8%; P = 0.02). The age group over 80 years showed the greatest increase in IHD mortality. Mortality from IHD is increasing in China, in contrast to decreasing in other countries. This is largely driven by increasing IHD mortality in rural areas and subjects over 80 years old. This needs urgent attention by public health workers and policymakers.

  5. Airport Barriers to Entry in the US

    National Research Council Canada - National Science Library

    Dresner M; Windle R; Yao Y


    An examination is conducted on the effects of three airport barriers to entry - slot controls, gate constraints, and gate utilisation during peak operating periods - on both yields and entry in the US airline...

  6. Bi-weekly waterfowl survey data entry (United States)

    US Fish and Wildlife Service, Department of the Interior — Data sheet for the entry of bi-weekly waterfowl survey data from the state of Kansas. This Excel file contains the data entry sheet and a chart displaying waterfowl...

  7. Essays on Empirical Industrial Organization : Entry and Innovation

    NARCIS (Netherlands)

    Fernandez Machado, Roxana


    The dissertation contains three essays on empirical industrial organization devoted to studying firms' strategic interaction in different settings. The first essay develops an entry model to address an important matter in the area of urban economics: the development of cities. In particular, it

  8. Risk Factors for Mosquito House Entry in the Lao PDR

    NARCIS (Netherlands)

    Hiscox, A.F.; Khammanithong, P.; Kaul, S.; Sananikhom, P.; Luthi, R.; Hill, N.; Brey, P.T.; Lindsay, S.W.


    Background Construction of the Nam Theun 2 hydroelectric project and flooding of a 450 km2 area of mountain plateau in south-central Lao PDR resulted in the resettlement of 6,300 people to newly built homes. We examined whether new houses would have altered risk of house entry by mosquitoes compared

  9. Flavivirus Entry Receptors: An Update

    Directory of Open Access Journals (Sweden)

    Manuel Perera-Lecoin


    Full Text Available Flaviviruses enter host cells by endocytosis initiated when the virus particles interact with cell surface receptors. The current model suggests that flaviviruses use at least two different sets of molecules for infectious entry: attachment factors that concentrate and/or recruit viruses on the cell surface and primary receptor(s that bind to virions and direct them to the endocytic pathway. Here, we present the currently available knowledge regarding the flavivirus receptors described so far with specific attention to C-type lectin receptors and the phosphatidylserine receptors, T-cell immunoglobulin and mucin domain (TIM and TYRO3, AXL and MER (TAM. Their role in flavivirus attachment and entry as well as their implication in the virus biology will be discussed in depth.

  10. 19 CFR 122.42 - Aircraft entry. (United States)


    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Aircraft entry. 122.42 Section 122.42 Customs... AIR COMMERCE REGULATIONS Aircraft Entry and Entry Documents; Electronic Manifest Requirements for Passengers, Crew Members, and Non-Crew Members Onboard Commercial Aircraft Arriving In, Continuing Within...

  11. Outer planet atmospheric entry probes - An overview of technology readiness (United States)

    Vojvodich, N. S.; Reynolds, R. T.; Grant, T. L.; Nachtsheim, P. R.


    Entry probe systems for characterizing, by in situ measurements, the atmospheric properties, chemical composition, and cloud structure of the planets Saturn, Uranus, and Jupiter are examined from the standpoint of unique mission requirements, associated subsystem performance, and degree of commonality of design. Past earth entry vehicles (PAET) and current planetary spacecraft (Pioneer Venus probes and Viking lander) are assessed to identify the extent of potential subsystem inheritance, as well as to establish the significant differences, in both form and function, relative to outer planet requirements. Recent research results are presented and reviewed for the most critical probe technology areas, including: science accommodation, telecommunication, and entry heating and thermal protection. Finally presented is a brief discussion of the use of decision analysis techniques for quantifying various probe heat-shield test alternatives and performance risk.

  12. Predicting the Diversity of Foreign Entry Modes

    DEFF Research Database (Denmark)

    Hashai, Niron; Geisler Asmussen, Christian; Benito, Gabriel


    This paper expands entry mode literature by referring to multiple modes exerted in different value chain activities within and across host markets, rather than to a single entry mode at the host market level. Scale of operations and knowledge intensity are argued to affect firms' entry mode...... diversity across value chain activities and host markets. Analyzing a sample of Israeli based firms we show that larger firms exhibit a higher degree of entry mode diversity both across value chain activities and across host markets. Higher levels of knowledge intensity are also associated with more...... diversity in firms' entry modes across both dimensions....

  13. ERDA energy information data base subject thesaurus

    Energy Technology Data Exchange (ETDEWEB)


    The technical staff of the ERDA Technical Information Center, during its subject indexing activities, develops and structures a vocabulary that allows consistent machine storage and retrieval of information necessary to the accomplishment of the ERDA mission. This thesaurus incorporates that structured vocabulary. Terms in the thesaurus are listed alphabetically; each alphabetic entry is accompanied by a ''word block'' containing all the terms associated with the entry. (RWR)

  14. ERDA energy information data base: subject thesaurus

    Energy Technology Data Exchange (ETDEWEB)


    The technical staff of the ERDA Technical Information Center, as part of its subject indexing activities, develops and structures a vocabulary which allows consistent machine storage and retrieval of information. This thesaurus incorporates that structured vocabulary. Terms in the thesaurus are listed alphabetically; each entry is accompanied by a ''word block'' containing all the terms associated with the entry. There are 15,905 approved terms and 4198 forbidden terms in this edition. (RWR)

  15. A Structural Equation Model Analyzing the Relationship of Student Achievement Motivations and Personality Factors in a Range of Academic Subject-Matter Areas (United States)

    Tempelaar, Dirk T.; Gijselaers, Wim H.; Schim van der Loeff, Sybrand; Nijhuis, Jan F. H.


    The question of subject-specificity of achievement motivations is important, both for educational psychology, as well as for educational policy. This study contributes to the investigation of the heterogeneity in achievement motivations in the context of the expectancy-value model. Whereas existing research deals with middle and high school…

  16. Masticatory and cervical muscle tenderness and pain sensitivity in a remote area in subjects with a temporomandibular disorder and neck disability. (United States)

    Silveira, Anelise; Armijo-Olivo, Susan; Gadotti, Inae C; Magee, David


    To compare the masticatory and cervical muscle tenderness and pain sensitivity in the hand (remote region) between patients with temporomandibular disorders (TMD) and healthy controls. Twenty female subjects were diagnosed with chronic TMD, and 20 were considered healthy. Subjects completed the Neck Disability Index and Limitations of Daily Functions in a TMD questionnaire. Tenderness of the masticatory and cervical muscles and pain sensitivity in the hand were measured using an algometer. Three-way mixed analysis of variance (ANOVA) evaluated differences in muscle tenderness between groups. One-way ANOVA compared pain sensitivity in the hand between groups. Effect sizes were assessed using Cohen guidelines. Significantly increased masticatory and cervical muscle tenderness and pain sensitivity in the hand were found in subjects with TMD when compared with healthy subjects. Moderate to high effect sizes showed the clinical relevance of the findings. The results of this study have highlighted the importance of assessing TMD patients not only in the craniofacial region but also in the neck and other parts of the body. Future studies should focus on testing the effectiveness of treatments addressing the neck and the pain sensitivity in the hand in patients with TMD.

  17. Multi-Mission Earth Entry Vehicle: Aerodynamic and Aerothermal Analysis of Trajectory Environments (United States)

    Trumble, Kerry; Dyakonov, Artem; Fuller, John


    Multi-mission Earth Entry Vehicle (MMEEV) is designed to deliver small payloads from space to Earth's surface by flying an uncontrolled ballistic entry, which ends with ground impact. The included range of entry velocities is from 10 to 16 km/s. The range of ballistic coefficients is from 41.94 to 128.74 kg/m2, which insures a low subsonic terminal velocity on the order of 50 m/sec. The range of entry flight path angles, considered in this analysis is from -5 to -25 degrees. The assessment and parametric characterization of aeroheating and aerodynamic performance of the capsule during entry is the subject of this paper.

  18. Titan Atmospheric Entry Radiative Heating (United States)

    Brandis, Aaron; Cruden, Brett


    Detailed spectrally and spatially resolved radiance has been measured in the Electric Arc Shock Tube for conditions relevant to Titan entry, varying atmospheric composition, free-stream density (equivalent to altitude) and shock velocity. Permutations in atmospheric composition include 1.1, 2, 5 and 8.6 CH4 by mole with a balance of N2 and 1.5 CH4 0.5 Ar 98 N2 by mole, which is consistent with the current understanding of Titan's atmosphere. The effect of gas impurities identified in previous shock tube studies were also examined by testing in pure N2 and deliberate addition of air to the CH4N2 mixtures. The test campaign measured radiation at velocities from 4.7 kms to 8 kms and free-stream pressures from 0.1 to 0.47 Torr. These conditions cover a range of potential trajectories for flight missions, including a direct ballistic trajectory, a fly by or an extremely high speed entry. Radiances measured in this work are substantially larger compared to that reported both in past EAST test campaigns and other shock tube facilities. Depending on the metric used for comparison, the discrepancy can be as high as an order of magnitude. Potential causes for the discrepancy, such as the effect of oxygen due to Air leakage, gas composition and purity are discussed. The present work provides a new benchmark set of data to replace those published in previous studies.

  19. BeppoSAX equatorial uncontrolled re-entry (United States)

    Portelli, C.

    The X-ray astronomy satellite BeppoSAX (Satellite per Astronomia X, "Beppo" in honor of Giuseppe Occhialini), is a project of the Italian Space Agency (ASI) with participation of the Netherlands Agency for Aerospace Programs (NIVR). BeppoSAX was launched by an Atlas G Centaur directly into a circular 600 km- orbit at 3.9 degrees inclination on April 30th, 1996. The satellite is a three axis stabilized spacecraft with a total mass of about 1400 kg. The current (May 1, 2002) flight altitude is about 470 km and its uncontrolled re-entry is predicted late in 2002, or in 2003, with a 26 kg of hydrazine on board that could not be vented or used for controlled re-entry due to gyro's package total failure. Due to the relatively high mass of BeppoSAX, it has to be expected that parts of the satellite will survive the re-entry into the earth atmosphere. The Italian Space Agency has committed a study to HTG for the analysis of the destructive phase of the uncontrolled atmospheric re-entry by means of a dedicated European software tool (SCARAB). The expected outputs will be used in order to determine how much of the spacecraft and how many fragments parts of it will reach the ground on the equatorial earth zone. This paper will address the peculiarities of the spacecraft initial status, its risks at end of life and the SCARAB modelling as well as its 6D flight dynamics re-entry analysis results also in terms of the destruction history tree. Consideration will be made on the ground dispersion and casualt y area due to the very restricted equatorial zone impacted. References B. Fritsche, H. Klinkrad, A. Kashkovsky, E.Grinberg; Spacecraft Disintegration during uncontrolled atmospheric entry ; IAA-99-IAA.6.7.02; 50t h IAC 4-8 Oct. 1999

  20. Optometry Australia Entry-level Competency Standards for Optometry 2014. (United States)

    Kiely, Patricia M; Slater, Jared


    Competency standards for entry-level to the profession of optometry in Australia were first developed in 1993, revised in 1997 and 2000, and again in 2008, when therapeutic competency standards were introduced but differentiated from the entry-level competencies. Therapeutic competencies were an additional requirement for the purpose of endorsing optometric registration to allow prescription of medicines for conditions of the eye. Recent changes to educational and registration requirements mean that therapeutic competencies are now required at entry-level. To address this and to ensure the standards reflect current best practice, a full revision of the standards was undertaken. A steering committee oversaw the review of the standards, which involved a literature review, workshops with optometrists and broad consultation with stakeholders, including the Optometry Board of Australia, individual optometrists and employers of optometrists, to identify changes needed. Representatives of the profession from Australia and New Zealand and from academia in Australia were involved. A modified document based on the feedback received was circulated to the State Divisions and the National Board of the then Optometrists Association Australia. The updated standards reflect the state of entry to the optometric profession in 2014; competencies for prescribing of scheduled medicines are included, new material has been added, other areas have been modified. The updated entry-level competency standards were adopted on behalf of the profession by the National Board of the then Optometrists Association Australia in March 2014. Competency standards have been updated so that they continue to be current and useful for the profession, individual optometrists and Australian and New Zealand registration authorities for the purposes of accreditation of optometric programs and assessment of overseas-trained optometrists. This paper details the revision process and presents the 2014 version of

  1. Immediate Effects of Combining Local Techniques in the Craniomandibular Area and Hamstring Muscle Stretching in Subjects with Temporomandibular Disorders: A Randomized Controlled Study. (United States)

    Rodriguez-Blanco, Cleofás; Cocera-Morata, Francisco Miguel; Heredia-Rizo, Alberto Marcos; Ricard, François; Almazán-Campos, Ginés; Oliva-Pascual-Vaca, Ángel


    To assess the immediate effects on vertical mouth opening, orofacial mechanosensitivity, and lumbar and suboccipital mobility after adding a myofascial induction technique to a multimodal protocol in subjects with temporomandibular disorders (TMD). A randomized and double-blind controlled trial was carried out. University-based physical therapy research clinic. Sixty subjects (35±11.22 years) with TMD, and restricted mobility of the mandibular condyles and the first cervical vertebrae, were recruited and randomized to either a control group (CG) (n=30) or an experimental group (EG) (n=30). The CG underwent a neuromuscular technique over the masseter muscles and passive hamstring muscle stretching. A suboccipital muscle inhibition technique was added to this protocol in the EG. Primary measurements were made of vertical mouth opening and pressure pain threshold of the masseter muscles. Secondary outcome measures included pressure algometry of the trigeminal nerve, suboccipital range of motion, and lumbar spine mobility, assessed with the sit-and-reach (SAR) test and lumbar forward bending. All evaluations were collected at baseline and immediately after intervention. In the intragroup comparison, the EG observed an increase in suboccipital flexion (p0.05). The inclusion of a myofascial induction maneuver in a protocol combining local (neuromuscular treatment) and distal techniques (hamstring stretching) in subjects with TMD has no impact on improving mouth opening, suboccipital and lumbar mobility, and orofacial sensitivity to mechanical pressure.

  2. Preventing re-entry to foster care. (United States)

    Carnochan, Sarah; Rizik-Baer, Daniel; Austin, Michael J


    Re-entry to foster care generally refers to circumstances in which children who have been discharged from foster care to be reunified with their family of origin, adopted, or provided kinship guardianship are returned to foster care. In the context of the federal performance measurement system, re-entry refers specifically to a return to foster care following an unsuccessful reunification. The federal Children and Family Services Review measures re-entry to foster care with a single indicator, called the permanency of reunification indicator, one of four indicators comprising the reunification composite measure. This review focuses on research related to the re-entry indicator, including the characteristics of children, caregivers and families, as well as case and child welfare services that are associated with a higher or lower risk of re-entry to foster care. Promising post-reunification services designed to prevent re-entry to foster care are described.

  3. Risk Assessment for Destructive Re-Entry (United States)

    Lips, T.; Koppenwallner, G.; Bianchi, L.; Klinkrad, H.


    From 2007 to 2008, Hypersonic Technology Göttingen (HTG) worked on a study called Risk Assessment for Destructive Re-entry (RADR). The main purposes of this study were to identify and to quantify the inherent uncertainties of re-entry analysis tools, and to provide possible risk mitigation measures. For these purposes, three basic risk scenarios were specified: a 1-ton-class satellite without propulsion for uncontrolled re-entry, a 6-ton-class satellite with propulsion and the capability to perform a controlled re-entry, and a 1-ton-class launcher upper stage re-entering uncontrolled. Based on the identified uncertainty parameters, variation analyses were conducted for these scenarios with the two ESA tools for re-entry analysis SCARAB (Spacecraft Atmospheric Reentry and Aerothermal Breakup) and SESAM (Spacecraft Entry Survival Analysis Module). This paper describes the major results of the RADR study.

  4. Entry menus in bilingual electronic dictionaries


    Lew, Robert; Tokarek, Patryk


    The study undertakes to assess the efficiency of entry menus in bilingual dictionaries in the electronic format. An experimental dictionary interface is tested for performance in terms of access speed and task success. The task underlying dictionary use is guided Polish-to-English translation, performed under three conditions by 90 Polish learners of English. The first version of the dictionary displays a complete polysemous entry immediately after an entry is selected. In the second version ...

  5. A comparison of human jaw muscle cross-sectional area and volume in long- and short-face subjects, using MRI

    NARCIS (Netherlands)

    Boom, H.P.W.; van Spronsen, P.H.; van Ginkel, F.C.; van Schijndel, R.A.; Castelijns, J.A.; Tuinzing, D.B.


    Objective In humans, the vertical craniofacial dimensions vary significantly with the size of the jaw muscles, which are regarded as important controlling factors of craniofacial growth. The functional relevance of the maximum cross-sectional area (CSA), indicating maximum muscle strength, is

  6. A comparison of human jaw muscle cross-sectional area and volume in long- and short-face subjects, using MRI

    NARCIS (Netherlands)

    van Spronsena, P. H.; van Ginkel, F. C.; van Schijndel, R. A.; Castelijns, J. A.; Tuinzing, D. B.

    Objective: In humans, the vertical craniofacial dimensions vary significantly with the size of the jaw muscles, which are regarded as important controlling factors of craniofacial growth. The functional relevance of the maximum cross-sectional area (CSA), indicating maximum muscle strength, is

  7. A comparison of human jaw muscle cross-sectional area and volume in long- and short-face subjects, using MRI

    NARCIS (Netherlands)

    Boom, H.P.; van Spronsen, P.H.; van Ginkel, F.C.; van Schijndel, R.A.; Castelijns, J.A.; Tuinzing, D.B.


    Objective: In humans, the vertical craniofacial dimensions vary significantly with the size of the jaw muscles, which are regarded as important controlling factors of craniofacial growth. The functional relevance of the maximum cross-sectional area (CSA), indicating maximum muscle strength, is

  8. Ultrasound screening for asymptomatic carotid stenosis in subjects with calcifications in the area of the carotid arteries on panoramic radiographs: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Karp Kjell


    Full Text Available Abstract Background Directed ultrasonic screening for carotid stenosis is cost-effective in populations with > 5% prevalence of the diagnosis. Occasionally, calcifications in the area of the carotid arteries are incidentally detected on odontological panoramic radiographs. We aimed to determine if directed screening for carotid stenosis with ultrasound is indicated in individuals with such calcifications. Methods This was a cross-sectional study. Carotid ultrasound examinations were performed on consecutive persons, with findings of calcifications in the area of the carotid arteries on panoramic radiography that were otherwise eligible for asymptomatic carotid endarterectomy. Results Calcification in the area of the carotid arteries was seen in 176 of 1182 persons undergoing panoramic radiography. Of these, 117 fulfilled the inclusion criterion and were examined with carotid ultrasound. Eight persons (6.8%; 95% CI 2.2-11.5% had a carotid stenosis - not significant over the 5% pre-specified threshold (p = 0.232, Binomial test. However, there was a significant sex difference (p = 0.008, as all stenoses were found in men. Among men, 12.5% (95%CI 4.2-20.8% had carotid stenosis - significantly over the 5% pre-specified threshold (p = 0.014, Binomial test. Conclusions The incidental finding of calcification in the area of the carotid arteries on panoramic radiographs should be followed up with carotid screening in men that are otherwise eligible for asymptomatic carotid endarterectomy. Trial Registration The study was registered at; NCT00514644

  9. Teenagers' Significant Experiences in Areas of Arts: A Study of the Subjectively Felt Impact and Some Qualitative Aspects of Experiences Involving Productive Arts Activities (United States)

    Finnas, Leif


    As a part of a larger project, this study focused primarily on Finland-Swedish ninth-graders' "productive" arts experiences (involving music-making, acting, writing, painting/drawing, dancing), as these had been reported when the pupils had been asked to write down descriptions of "strong" experiences in arts areas (music,…

  10. Innate immunity modulation in virus entry. (United States)

    Faure, Mathias; Rabourdin-Combe, Chantal


    Entry into a cell submits viruses to detection by pattern recognition receptors (PRRs) leading to an early innate anti-viral response. Several viruses evolved strategies to avoid or subvert PRR recognition at the step of virus entry to promote infection. Whereas viruses mostly escape from soluble PRR detection, endocytic/phagocytic PRRs, such as the mannose receptor or DC-SIGN, are commonly used for virus entry. Moreover, virion-incorporated proteins may also offer viruses a way to dampen anti-viral innate immunity upon virus entry, and entering viruses might usurp autophagy to improve their own infectivity. Copyright © 2011 Elsevier B.V. All rights reserved.

  11. Retroviral host range extension is coupled with Env-activating mutations resulting in receptor-independent entry

    Czech Academy of Sciences Publication Activity Database

    Lounková, Anna; Kosla, Jan; Přikryl, David; Štafl, Kryštov; Kučerová, Dana; Svoboda, Jan


    Roč. 114, č. 26 (2017), E5148-E5157 ISSN 0027-8424 R&D Projects: GA ČR GA15-22207S Institutional support: RVO:68378050 Keywords : Rous sarcoma virus * retrovirus * virus entry * envelope glycoprotein * receptor-independent entry Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 9.661, year: 2016

  12. School Entry, Educational Attainment and Quarter of Birth: A Cautionary Tale of LATE. NBER Working Paper No. 15236 (United States)

    Barua, Rashmi; Lang, Kevin


    Partly in response to increased testing and accountability, states and districts have been raising the minimum school entry age, but existing studies show mixed results regarding the effects of entry age. These studies may be severely biased because they violate the monotonicity assumption needed for LATE. We propose an instrument not subject to…

  13. Gene Therapy Targeting HIV Entry

    Directory of Open Access Journals (Sweden)

    Chuka Didigu


    Full Text Available Despite the unquestionable success of antiretroviral therapy (ART in the treatment of HIV infection, the cost, need for daily adherence, and HIV-associated morbidities that persist despite ART all underscore the need to develop a cure for HIV. The cure achieved following an allogeneic hematopoietic stem cell transplant (HSCT using HIV-resistant cells, and more recently, the report of short-term but sustained, ART-free control of HIV replication following allogeneic HSCT, using HIV susceptible cells, have served to both reignite interest in HIV cure research, and suggest potential mechanisms for a cure. In this review, we highlight some of the obstacles facing HIV cure research today, and explore the roles of gene therapy targeting HIV entry, and allogeneic stem cell transplantation in the development of strategies to cure HIV infection.

  14. Changes in Cerebral Hemodynamics during Complex Motor Learning by Character Entry into Touch-Screen Terminals.

    Directory of Open Access Journals (Sweden)

    Akira Sagari

    Full Text Available Studies of cerebral hemodynamics during motor learning have mostly focused on neurorehabilitation interventions and their effectiveness. However, only a few imaging studies of motor learning and the underlying complex cognitive processes have been performed.We measured cerebral hemodynamics using near-infrared spectroscopy (NIRS in relation to acquisition patterns of motor skills in healthy subjects using character entry into a touch-screen terminal. Twenty healthy, right-handed subjects who had no previous experience with character entry using a touch-screen terminal participated in this study. They were asked to enter the characters of a randomly formed Japanese syllabary into the touch-screen terminal. All subjects performed the task with their right thumb for 15 s alternating with 25 s of rest for 30 repetitions. Performance was calculated by subtracting the number of incorrect answers from the number of correct answers, and gains in motor skills were evaluated according to the changes in performance across cycles. Behavioral and oxygenated hemoglobin concentration changes across task cycles were analyzed using Spearman's rank correlations.Performance correlated positively with task cycle, thus confirming motor learning. Hemodynamic activation over the left sensorimotor cortex (SMC showed a positive correlation with task cycle, whereas activations over the right prefrontal cortex (PFC and supplementary motor area (SMA showed negative correlations.We suggest that increases in finger momentum with motor learning are reflected in the activity of the left SMC. We further speculate that the right PFC and SMA were activated during the early phases of motor learning, and that this activity was attenuated with learning progress.

  15. 10 CFR 835.501 - Radiological areas. (United States)


    ... 10 Energy 4 2010-01-01 2010-01-01 false Radiological areas. 835.501 Section 835.501 Energy DEPARTMENT OF ENERGY OCCUPATIONAL RADIATION PROTECTION Entry Control Program § 835.501 Radiological areas. (a) Personnel entry control shall be maintained for each radiological area. (b) The degree of control shall be...

  16. Border Crossing/Entry Data - Border Crossing/Entry Data Time Series tool (United States)

    Department of Transportation — The dataset is known as “Border Crossing/Entry Data.” The Bureau of Transportation Statistics (BTS) Border Crossing/Entry Data provides summary statistics to the...

  17. Graduate entry students' early perceptions of their future nursing careers. (United States)

    McKenna, Lisa; Brooks, Ingrid


    Graduate entry nursing programs designed for individuals with prior degrees in other disciplines are becoming increasingly popular internationally. They provide entry into nursing for people with unique skill-sets. Yet, little is known about why these individuals choose career change into nursing and what they expect from their new careers. This component of a larger study sought to explore graduate entry nursing students' short and longer term career intentions on commencement of their courses. A cross-sectional survey was used. Descriptive frequencies were used to analyse demographic data, while summative content analysis was used with the open-ended questions. Participants were drawn from eight cohorts of commencing students from enrolled in one graduate entry masters program in Australia between 2009 and 2015. Content analysis identified three main categories: professional role, work location, and work context. Longer term responses were categorised under four categories: professional role, work location, work context and personal and professional goals. Many students had clear directions about their future nursing careers. On graduation, many envisioned working in advanced roles or in clinical specialty areas, primarily in hospital settings. However, in the longer term, there was diversity among with many envisaging work outside traditional hospital settings, and some in other health disciplines. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

  18. Expanding subjectivities

    DEFF Research Database (Denmark)

    Lundgaard Andersen, Linda; Soldz, Stephen


    A major theme in recent psychoanalytic thinking concerns the use of therapist subjectivity, especially “countertransference,” in understanding patients. This thinking converges with and expands developments in qualitative research regarding the use of researcher subjectivity as a tool to understa...

  19. Subject thesaurus permuted listing: Energy Data Base

    Energy Technology Data Exchange (ETDEWEB)

    Raridon, M.H. (ed.)


    This permuted listing, an appendix to the Energy Data Base: Subject Thesaurus (DOE/TIC-7000-R6), has been prepared to alleviate the problems of entry to a large multidisciplinary thesaurus containing both single and multi-word descriptors. It is designed to be used in conjunction with the Subject Thesaurus and is not to be used alone. Each descriptor, whether a single word or multi-word entry, has been permuted and alphabetized by each significant word. The complete descriptor is given at each point.

  20. 19 CFR 147.11 - Entry. (United States)


    ...) TRADE FAIRS Procedure for Importation § 147.11 Entry. (a) Made in name of fair operator. All entries of articles for a fair shall be made at the port in the name of the fair operator which shall be deemed for... exhibition purposes under the Trade Fair Act of 1959. Mark Number Package and contents Quality Invoice value...

  1. Strategic Entry Deterrence Modeling: Literature Review

    Directory of Open Access Journals (Sweden)

    D. A. Seliverstov


    Full Text Available The prime focus in this article is on key findings concerning theoretical aspects of strategic behavior by incumbents to deter market entry of new firms. The author summarizes main lines of scientific research in the topic which give an insight into the patterns of the incumbent’s impact on the behavior of the entrants, the entry deterrence instruments and the consequences of these actions. Today the free entry markets are considered to be a rare phenomenon. The market entry of new firms is associated with significant entry costs, which allow the incumbents to take advantage of their dominant position and derive positive economic profits. In case of entry threat by potential competitors the incumbents take strategic actions aimed at deterring entry and preserving their dominant position. Among the most efficient strategic actions one can emphasize the erection of additional barriers to entry for the newcomers through producing the limit output and price, investments in sunk assets, capacity expansion and product differentiation. Meanwhile by taking strategic actions the incumbents are not always trying to affect the entrant’s costs and profit directly, they often aim at changing the entrant’s expectations regarding future intentions of the incumbents to preserve dominant position.

  2. 27 CFR 27.184 - Entry documents. (United States)


    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Entry documents. 27.184 Section 27.184 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... Distilled Spirits From Customs Custody Free of Tax for Use of the United States § 27.184 Entry documents...

  3. Factors associated with poor nutritional status among community dwelling Lebanese elderly subjects living in rural areas: results of the AMEL study. (United States)

    Boulos, C; Salameh, P; Barberger-Gateau, P


    This study aimed to assess the nutritional status, measured by MNA, and its association with socio-demographic indicators and health related characteristics of a representative sample of community dwelling elderly subjects. Cross-sectional study. Community dwelling elderly individuals living in rural communities in Lebanon. 1200 elderly individuals aged 65 years or more. Socio-demographic indicators and health related characteristics were recorded during a standardized interview. Nutritional status was assessed through Mini Nutritional Assessment (MNA). The 5-item GDS score and the WHO-5-A score were used to assess mood, whereas Mini Mental Status (MMS) was applied to evaluate cognitive status. The prevalence of malnutrition and risk of malnutrition was 8.0% respective 29.1% of the study sample. Malnutrition was significantly more frequent in elderly subjects aged more than 85 years, in females, widowed and illiterate people. Moreover, participants who reported lower financial status were more often malnourished or at risk of malnutrition. Regarding health status, poor nutritional status was more common among those reporting more than three chronic diseases, taking more than three drugs daily, suffering from chronic pain and those who had worse oral health status. Also, depressive disorders and cognitive dysfunction were significantly related to malnutrition. After multivariate analysis following variables remained independently associated to malnutrition: living in the governorate of Nabatieh (ORa 2.30, 95% CI 1.35 -3.93), reporting higher income (ORa 0.77, 95% CI 0.61-0.97), higher number of comorbidities (ORa 1.22, 95% CI 1.12-1.32), chronic pain (ORa 1.72, 95% CI 1.24-2.39), and depressive disorders (ORa 1.66, 95% CI 1.47-1.88). On the other hand, better cognitive functioning was strongly associated with decreased nutritional risk (ORa 0.27, 95%CI 0.17-0.43). Our results highlighted the close relationship between health status and malnutrition. The

  4. Stoichiometric parameters of HIV-1 entry. (United States)

    Zarr, Melissa; Siliciano, Robert


    During HIV type 1 (HIV-1) entry, trimers of gp120 bind to CD4 and either the CCR5 or CXCR4 coreceptor on the target cell. The stoichiometric parameters associated with HIV-1 entry remain unclear. Important unanswered questions include: how many trimers must attach to CD4 molecules, how many must bind coreceptors, and how many functional gp120 subunits per trimer are required for entry? We performed single round infectivity assays with chimeric viruses and compared the experimental relative infectivity curves with curves generated by mathematical models. Our results indicate that HIV-1 entry requires only a small number of functional spikes (one or two), that Env trimers may function with fewer than three active subunits, and that there is no major difference in the stoichiometric requirements for CCR5 vs. CXCR4 mediated HIV-1 entry into host cells. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Orion Entry Display Feeder and Interactions with the Entry Monitor System (United States)

    Baird, Darren; Bernatovich, Mike; Gillespie, Ellen; Kadwa, Binaifer; Matthews, Dave; Penny, Wes; Zak, Tim; Grant, Mike; Bihari, Brian


    The Orion spacecraft is designed to return astronauts to a landing within 10 km of the intended landing target from low Earth orbit, lunar direct-entry, and lunar skip-entry trajectories. Al pile the landing is nominally controlled autonomously, the crew can fly precision entries manually in the event of an anomaly. The onboard entry displays will be used by the crew to monitor and manually fly the entry, descent, and landing, while the Entry Monitor System (EMS) will be used to monitor the health and status of the onboard guidance and the trajectory. The entry displays are driven by the entry display feeder, part of the Entry Monitor System (EMS). The entry re-targeting module, also part of the EMS, provides all the data required to generate the capability footprint of the vehicle at any point in the trajectory, which is shown on the Primary Flight Display (PFD). It also provides caution and warning data and recommends the safest possible re-designated landing site when the nominal landing site is no longer within the capability of the vehicle. The PFD and the EMS allow the crew to manually fly an entry trajectory profile from entry interface until parachute deploy having the flexibility to manually steer the vehicle to a selected landing site that best satisfies the priorities of the crew. The entry display feeder provides data from the ENIS and other components of the GNC flight software to the displays at the proper rate and in the proper units. It also performs calculations that are specific to the entry displays and which are not made in any other component of the flight software. In some instances, it performs calculations identical to those performed by the onboard primary guidance algorithm to protect against a guidance system failure. These functions and the interactions between the entry display feeder and the other components of the EMS are described.

  6. Psychosocial working conditions, school sense of coherence and subjective health complaints. A multilevel analysis of ninth grade pupils in the Stockholm area. (United States)

    Modin, Bitte; Ostberg, Viveca; Toivanen, Susanna; Sundell, Knut


    This study explores the psychosocial working conditions of 7930 Swedish 9th grade students, distributed over 475 classes and 130 schools, in relation to their subjective health using multilevel modeling. At the individual level, students with "strained" working conditions in school (i.e. those experiencing a high level of demands in combination with a low level of control) demonstrated significantly worse health compared to students in "low-strain" situations. "Strained" conditions in combination with a weak school-related sense of coherence were especially unfavourable for health. These findings remained significant when support from teachers, school marks, norm-breaking behaviours, family-relations and certain class- and school-contextual conditions were adjusted for. Thus, while demands are an essential part of school work, this study suggests that high levels of control and a strong school-related sense of coherence can protect against the more detrimental effects on health that high demands at school may cause. Copyright © 2010 The Association for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

  7. Experimental Economics on Firm’s Behavior: Entry Game Approach

    Directory of Open Access Journals (Sweden)

    I Wayan Sukadana


    Full Text Available The paper analyzes subject’s behavior in evolutionary process of entry game. The experiment is designed to analyze the behavior of the subject. The experiment is set in sequential entry games. Process of the game was conducted under asymmetric information, uncertainty, payoff perturbation and random matching. The subjects of the experiment were students of the Universitas Udayana, Bali, Indonesia. Subjects who play as new-entrance firms tend to choose “stay-out” strategy when the uncertainty and the amount of loss increase. Meanwhile, the subjects who play as an incumbent firm, which set to have more information about the game (market rather than the new-entrances, most of the time abuse their position by choose “threat” strategy, which not a credible strategy for some of them. Experimental studies shows that New-entrance tend to weight more on lost when the risk increase (from risk averse setting to risk seeking setting, and tend to choose sure value over a lotteries although the expected value from lotteries is higher or the same. These findings support the reason that Indonesian youngsters tend to choose a job as a PNS or employee of existing firms. The results also support the reason that Indonesian businessman is more willing to open a new business if they have a guarantee for their losses.

  8. Design of a Self Don/Doffing Rear Entry Planetary Suit to Interface with a Suit Port/Lock Project (United States)

    National Aeronautics and Space Administration — Under Phase 1 of subject SBIR, Air-Lock, Incorporated will design a self donning and doffing Rear Entry Hard Upper Torso (REHUT) that interfaces with a suit port....

  9. 50 CFR 91.22 - Display of contest entries. (United States)


    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Display of contest entries. 91.22 Section... Administering the Contest § 91.22 Display of contest entries. The Federal Duck Stamp Office assigns all eligible entries a number as entries are received. That office displays the entries in numerical order at the...


    Energy Technology Data Exchange (ETDEWEB)



    We have assembled a system using a personal computer workstation equipped with standard office software, an audio system, speech recognition software and an inexpensive radio-based wireless microphone that permits laboratory workers to enter or modify data while performing other work. Speech recognition permits users to enter data while their hands are holding equipment or they are otherwise unable to operate a keyboard. The wireless microphone allows unencumbered movement around the laboratory without a ''tether'' that might interfere with equipment or experimental procedures. To evaluate the potential of voice data entry in a laboratory environment, we developed a prototype relational database that records the disposal of radionuclides and/or hazardous chemicals Current regulations in our laboratory require that each such item being discarded must be inventoried and documents must be prepared that summarize the contents of each container used for disposal. Using voice commands, the user enters items into the database as each is discarded. Subsequently, the program prepares the required documentation.

  11. Retrovirus Entry by Endocytosis and Cathepsin Proteases

    Directory of Open Access Journals (Sweden)

    Yoshinao Kubo


    Full Text Available Retroviruses include infectious agents inducing severe diseases in humans and animals. In addition, retroviruses are widely used as tools to transfer genes of interest to target cells. Understanding the entry mechanism of retroviruses contributes to developments of novel therapeutic approaches against retrovirus-induced diseases and efficient exploitation of retroviral vectors. Entry of enveloped viruses into host cell cytoplasm is achieved by fusion between the viral envelope and host cell membranes at either the cell surface or intracellular vesicles. Many animal retroviruses enter host cells through endosomes and require endosome acidification. Ecotropic murine leukemia virus entry requires cathepsin proteases activated by the endosome acidification. CD4-dependent human immunodeficiency virus (HIV infection is thought to occur via endosomes, but endosome acidification is not necessary for the entry whereas entry of CD4-independent HIVs, which are thought to be prototypes of CD4-dependent viruses, is low pH dependent. There are several controversial results on the retroviral entry pathways. Because endocytosis and endosome acidification are complicatedly controlled by cellular mechanisms, the retrovirus entry pathways may be different in different cell lines.

  12. Novel Approaches to Inhibit HIV Entry

    Directory of Open Access Journals (Sweden)

    Chukwuka A. Didigu


    Full Text Available Human Immunodeficiency Virus (HIV entry into target cells is a multi-step process involving binding of the viral glycoprotein, Env, to its receptor CD4 and a coreceptor—either CCR5 or CXCR4. Understanding the means by which HIV enters cells has led to the identification of genetic polymorphisms, such as the 32 base-pair deletion in the ccr5 gene (ccr5∆32 that confers resistance to infection in homozygous individuals, and has also resulted in the development of entry inhibitors—small molecule antagonists that block infection at the entry step. The recent demonstration of long-term control of HIV infection in a leukemic patient following a hematopoietic stem cell transplant using cells from a ccr5∆32 homozygous donor highlights the important role of the HIV entry in maintaining an established infection and has led to a number of attempts to treat HIV infection by genetically modifying the ccr5 gene. In this review, we describe the HIV entry process and provide an overview of the different classes of approved HIV entry inhibitors while highlighting novel genetic strategies aimed at blocking HIV infection at the level of entry.

  13. Inflatable Emergency Atmospheric-Entry Vehicles (United States)

    Jones, Jack; Hall, Jeffrey; Wu, Jiunn Jeng


    In response to the loss of seven astronauts in the Space Shuttle Columbia disaster, large, lightweight, inflatable atmospheric- entry vehicles have been proposed as means of emergency descent and landing for persons who must abandon a spacecraft that is about to reenter the atmosphere and has been determined to be unable to land safely. Such a vehicle would act as an atmospheric decelerator at supersonic speed in the upper atmosphere, and a smaller, central astronaut pod could then separate at lower altitudes and parachute separately to Earth. Astronaut-rescue systems that have been considered previously have been massive, and the cost of designing them has exceeded the cost of fabrication of a space shuttle. In contrast, an inflatable emergency-landing vehicle according to the proposal would have a mass between 100 and 200 kg, could be stored in a volume of approximately 0.2 to 0.4 cu m, and could likely be designed and built much less expensively. When fully inflated, the escape vehicle behaves as a large balloon parachute, or ballute. Due to very low mass-per-surface area, a large radius, and a large coefficient of drag, ballutes decelerate at much higher altitudes and with much lower heating rates than the space shuttle. Although the space shuttle atmospheric reentry results in surface temperatures of about 1,600 C, ballutes can be designed for maximum temperatures below 600 C. This allows ballutes to be fabricated with lightweight ZYLON(Registered TradeMark) or polybenzoxazole (PBO), or equivalent.

  14. An Innovative Approach for Gob-Side Entry Retaining in Thick Coal Seam Longwall Mining

    Directory of Open Access Journals (Sweden)

    Manchao He


    Full Text Available Gob-side entry retaining (GER is a popular non-pillar mining technique regarding how to reserve a gateroad for the use of next panel mining. When used in thick coal seams, the conventional entry retaining method requires a huge amount of filling materials and may cause entry (gateroad accidents. Thus, an innovative non-pillar longwall mining approach is introduced. First, structural and mechanical models were built to explore the mechanism of the new approach. The modeling results indicate that effective bulking of the gob roof and reasonable support of the entry roof were key governing factors in improving entry stabilities and reducing roof deformations. Accordingly, a directional roof fracturing technique was proposed to contribute to gob roof caving, and a constant resistance and large deformation anchor (CRLDA cable was used to stabilize the entry roof. Subsequently, the evolutionary laws of the roof structure and stresses were explored using numerical simulation. It was found that the structure of the surrounding rocks around the retained entry changed significantly after roof fracturing. The stress-bearing center was transferred to the gob area, and the entry roof was in a low stress environment after adopting the approach. Finally, the approach was tested on a thick coal seam longwall mining panel. Field monitoring indicates that the retained entry was in a stable state and the index of the retained entry met the requirement of the next mining panel. This work provides an effective and economical approach to non-pillar longwall mining in thick coal seams.

  15. Multiple biomarker responses in Prochilodus lineatus subjected to short-term in situ exposure to streams from agricultural areas in Southern Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Vieira, Carlos Eduardo Delfino [Laboratório de Ecofisiologia Animal — Departamento de Ciências Fisiológicas, Universidade Estadual de Londrina, Paraná (Brazil); Costa, Patrícia Gomes [Laboratório de Microcontaminantes Orgânicos e Ecotoxicologia — Instituto de Oceanografia, Universidade Federal do Rio Grande, Rio Grande do Sul (Brazil); Lunardelli, Bruna; Fernandes de Oliveira, Luciana [Laboratório de Ecofisiologia Animal — Departamento de Ciências Fisiológicas, Universidade Estadual de Londrina, Paraná (Brazil); Costa Cabrera, Liziara da [Laboratório de Análise de Compostos Orgânicos e Metais — Escola de Química e Alimentos, Universidade Federal do Rio Grande, Rio Grande do Sul (Brazil); Risso, Wagner Ezequiel [Laboratório de Ecofisiologia Animal — Departamento de Ciências Fisiológicas, Universidade Estadual de Londrina, Paraná (Brazil); Primel, Ednei Gilberto [Laboratório de Análise de Compostos Orgânicos e Metais — Escola de Química e Alimentos, Universidade Federal do Rio Grande, Rio Grande do Sul (Brazil); and others


    In order to assess the quality of streams susceptible to contamination by pesticides we apply biochemical and genotoxic biomarkers in the Neotropical fish Prochilodus lineatus submitted to in situ tests. Fish were caged, for 96 h, in two streams located in areas with intensive use of pesticides, the Apertados (AP) and the Jacutinga (JC), and in a small stream (Godoy stream — GD) found inside a forest fragment adjacent to a State Park. Biochemical parameters, such as biotransformation enzymes 7-ethoxyresorufin-O-deethylase (EROD) and glutathione-S-transferase (GST), non-protein thiols (NPSH), lipoperoxidation (LPO), protein carbonylation (PCO) and acetylcholinesterase (AChE) were evaluated in various fish organs, as well as genotoxic biomarkers (damage to DNA and occurrence of micronuclei and erythrocyte nuclear abnormalities). Samples of water and sediment were collected for analysis of metals (Cu, Cr, Pb, Ni, Mn, Cd and Zn), organochloride pesticides, and triazine and glyphosate herbicides. We observed an increase in liver GST activity in fish at AP and gill GST activity in fish at JC. An increase in liver LPO was also observed in fish exposed to AP and JC. The same animals also exhibited increased DNA damage and erythrocyte nuclear abnormalities (ENAs) compared to the fish kept in GD. A number of compounds showed concentrations higher than the permitted levels, in particular, dichlorodiphenyltrichloroethane (DDT), its metabolites dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyldichloroethane (DDD), hexachlorocyclohexanes (HCH), heptachloride, diclofluanid and aldrins. These pesticides were detected at higher concentrations in water and sediment samples from AP, followed by JC and GD. The Integrated Biomarker Response Index (IBR) indicated that AP and JC (AP: 21.7 > JC: 18.5 > GD: 12.6) have the worst environmental quality. Integrated biomarker analysis revealed that the alterations observed related well with the levels of environmental contaminants

  16. Hydrogeologic monitoring of the Paraíba do Sul river floodplain area subject to sand mining in the Tremembé municipality, SP, Brazil

    Directory of Open Access Journals (Sweden)

    Getulio Teixeira Batista


    Full Text Available To characterize the geological, hydrogeological, hydrochemical, and hydrobacterial aspects of the surface and groundwater in the floodplain of the Paraíba do Sul river in Tremembé municipality, the water levels of the Quaternary sedimentary aquifer experimental site was monitored based on four wells and eight associated piezometers with daily measures of water levels in continuous operation since December 3, 2009. In addition, data from a modular weather station in operation since March 2010 and data from the quality of surface water and groundwater have been analyzed in the period between March 2010 and March 2011. The water balance between April 2010 and March 2011 was estimated to verify the periods of water deficiency and excess. Data loggers installed in the piezometers enabled daily groundwater levels monitoring to establish the influence of the Paraíba do Sul river in the water levels of the Quaternary sedimentary aquifer and also they allowed the determination of the water loss to the atmosphere. A hydrogeological model with simplified equations, based on hydraulics parameters obtained in the wells pump tests, was implemented to calculate the amount of daily evapotranspiration and the average distance of the water loss from the wells to the atmosphere. An evaporation rate of 83.4 m3/h from the open-pit sand mine located at 212.2 m and of 89.2 m3/h for the one at 885.0 m average distance from the monitoring wells were observed. Chemical and bacteriological analysis involving multiple parameters were performed in the period from March 2010 to March 2011 in groundwater collected in wells, in the open-pit mines and in the waters of the Paraíba do Sul river. The results allowed to observe the influences of the Paraíba do Sul river as well as the contamination from fertilizers and pesticides from the agriculture practiced in the floodplain area on the quality of the groundwater.

  17. Entry Mode and Performance of Nordic Firms

    DEFF Research Database (Denmark)

    Wulff, Jesper


    This study investigates whether the relationship between mode of international market entry and non-location bound international experience is weaker for firms that are large or have a high foreign to total sales ratio, labeled multinational experience. Empirical evidence based on 250 foreign...... market entries made by Norwegian, Danish and Swedish firms suggests that the association between equity mode choice and non-location bound international experience diminishes in the presence of higher levels of multinational experience. Furthermore, firms whose entry mode choice is predicted by the model...

  18. Foreign Entry and Heterogeneous Growth of Firms

    DEFF Research Database (Denmark)

    Deng, Paul Duo; Jefferson, Gary H.

    We adopt the framework of Schumpeterian creative destruction formalized by Aghion et al. (2009) to analyze the impact of foreign entry on the productivity growth of domestic firms. In the face of foreign entry, domestic firms exhibit heterogeneous patterns of growth depending on their technological...... distance from foreign firms. Domestic firms with smaller technological distance from their foreign counterparts tend to experience faster productivity growth, while firms with larger technological distance tend to lag further behind. We test this hypothesis using a unique firm-level data of Chinese...... manufacturing. Our empirical results confirm that foreign entry indeed generates strong heterogeneous growth patterns among domestic firms....

  19. One-year transitional programme increases knowledge to level sufficient for entry into the fourth year of the medical curriculum

    NARCIS (Netherlands)

    Cohen-Schotanus, Janke; Schönrock-Adema, Johanna; Bouwkamp-Timmer, Tineke; van Scheltinga, Gerard R. Terwisscha; Kuks, Jan B. M.


    Background: To cope with a lack of doctors and in anticipation of the Bachelor-Master structure for Medicine, several Dutch universities offer graduate entry programmes for students with degrees in areas related to Medicine. The graduate entry programme is a four-year programme: after a transition


    Indian Academy of Sciences (India)

    Subject Index. Variation of surface electric field during geomagnetic disturbed period at Maitri, Antarctica. 1721. Geomorphology. A simple depression-filling method for raster and irregular elevation datasets. 1653. Decision Support System integrated with Geographic. Information System to target restoration actions in water-.

  1. Entry Systems Modeling (ESM) Project (United States)

    National Aeronautics and Space Administration — Cutting edge customer driven research in two areas:Aerosciences, including the completion and delivery of two new aerothermal CFD codes, a first ever validated shock...

  2. Market entry strategies into the BRIC countries

    DEFF Research Database (Denmark)

    Boyd, Britta; Dyhr Ulrich, Anna Marie


    Based on a sample of 177 exporting SMEs, this study investigates what market entry strategy is used by Danish family and non-family businesses. From a resource-based view, three critical internal factors (risk, flexibility and control) affecting the entry mode choice into the BRIC markets...... compared to non-family firms. Furthermore, the Danish exporters regarded China as being the most established of the four BRIC markets which could be seen in their willingness to use high control entry modes in China. Finally, non-family firms are more concerned about higher flexibility and lower control...... when entering the BRIC markets. In contrast, family firms choose high commitment entry modes which involve high risk and low flexibility when entering the BRIC markets. Further implications discuss the suitability of export strategies to BRIC markets for managers of Danish family and non-family firms....

  3. Adaptive Text Entry for Mobile Devices

    DEFF Research Database (Denmark)

    Proschowsky, Morten Smidt

    to improve the models of human motor behaviour. TUP-Key is a variant of TUP, designed for 12 key phone keyboards. It is introduced in the thesis but has not been implemented or evaluated. Both text entry methods support adaptive context-aware language models. YourText is a framework for adaptive context...... for mobile devices and a framework for adaptive context-aware language models. Based on analysis of current text entry methods, the requirements to the new text entry methods are established. Transparent User guided Prediction (TUP) is a text entry method for devices with one dimensional touch input. It can...... be touch sensitive wheels, sliders or similar input devices. The interaction design of TUP is done with a combination of high level task models and low level models of human motor behaviour. Three prototypes of TUP are designed and evaluated by more than 30 users. Observations from the evaluations are used...

  4. Border Crossing/Entry Data - Boarder Crossing (United States)

    Department of Transportation — Border Crossing/Entry Data provides summary statistics for incoming crossings at the U.S.-Canadian and the U.S.-Mexican border at the port level. Data are available...

  5. The Effects of Entry in Bilateral Oligopoly

    Directory of Open Access Journals (Sweden)

    Alex Dickson


    Full Text Available The purpose of this paper is to study the effects of entry into the market for a single commodity in which both sellers and buyers are permitted to interact strategically. With the inclusion of an additional seller, the market is quasi-competitive: the price falls and volume of trade increases, as expected. However, contrary to the conventional wisdom, existing sellers’ payoffs may increase. The conditions under which entry by new sellers raises the equilibrium payoffs of existing sellers are derived. These depend in an intuitive way on the elasticity of a strategic analog of demand and the market share of existing sellers, and encompass entirely standard economic environments. Similar results are derived relating to the entry of additional buyers and the effects of entry on both sides of the market are investigated.

  6. Remodeling of Calcium Entry Pathways in Cancer. (United States)

    Villalobos, Carlos; Sobradillo, Diego; Hernández-Morales, Miriam; Núñez, Lucía


    Ca(2+) entry pathways play important roles in control of many cellular functions, including long-term proliferation, migration and cell death. In recent years, it is becoming increasingly clear that, in some types of tumors, remodeling of Ca(2+) entry pathways could contribute to cancer hallmarks such as excessive proliferation, cell migration and invasion as well as resistance to cell death or survival. In this chapter we briefly review findings related to remodeling of Ca(2+) entry pathways in cancer with emphasis on the mechanisms that contribute to increased store-operated Ca(2+) entry (SOCE) and store-operated currents (SOCs) in colorectal cancer cells. Finally, since SOCE appears critically involved in colon tumorogenesis, the inhibition of SOCE by aspirin and other NSAIDs and its possible contribution to colon cancer chemoprevention is reviewed.

  7. Developing Quantitative Models for Auditing Journal Entries


    Argyrou, Argyris


    The thesis examines how the auditing of journal entries can detect and prevent financial statement fraud. Financial statement fraud occurs when an intentional act causes financial statements to be materially misstated. Although it is not a new phenomenon, financial statement fraud has attracted much publicity in the wake of numerous cases of financial malfeasance (e.g. ENRON, WorldCom). Existing literature has provided limited empirical evidence on the link between auditing journal entrie...

  8. Entry modes of European firms in Vietnam


    Daniel Simonet


    Purpose: The purpose of the paper is to explore the entry modes of EU firms setting up operations in Vietnam. Design/methodology/approach: we use a case study approach on Haymarket, Cadbury, Creative Education, Fairchild, Aventis and Artemisinin and Farming International using interviews from managerial professionals in Vietnam. Findings: Despite the fact that Vietnam has been opening up for more than 20 years, licensing is the preferred entry mode because of the risks involved in ventur...

  9. Limit pricing and secret barriers to entry


    Brighi, Luigi; D'Amato, Marcello


    We study a two periods entry game where the incumbent .rm, who has private information about his own production costs, makes a non observable long run investment choice, along with a pricing decision observed by the entrant. The investment choice affects both post-entry competition and first period cost of production, so that the cost of signaling becomes endogenous. The game is solved following Bayes-Nash requirements, the intuitive criterion is used to constrain off-equilibrium beliefs. Whe...

  10. Using the Theory of Planned Behaviour to Understand Students' Subject Choices in Post-Compulsory Education (United States)

    Taylor, Rachel Charlotte


    In recent years, there have been concerns in the UK regarding the uptake of particular subjects in post-compulsory education. Whilst entries for Advanced level (A-level) subjects such as media studies have experienced considerable growth, entries for A-level physics have, until recently, been declining, prompting fears of a skills crisis in future…

  11. Orion Capsule Handling Qualities for Atmospheric Entry (United States)

    Tigges, Michael A.; Bihari, Brian D.; Stephens, John-Paul; Vos, Gordon A.; Bilimoria, Karl D.; Mueller, Eric R.; Law, Howard G.; Johnson, Wyatt; Bailey, Randall E.; Jackson, Bruce


    Two piloted simulations were conducted at NASA's Johnson Space Center using the Cooper-Harper scale to study the handling qualities of the Orion Command Module capsule during atmospheric entry flight. The simulations were conducted using high fidelity 6-DOF simulators for Lunar Return Skip Entry and International Space Station Return Direct Entry flight using bank angle steering commands generated by either the Primary (PredGuid) or Backup (PLM) guidance algorithms. For both evaluations, manual control of bank angle began after descending through Entry Interface into the atmosphere until drogue chutes deployment. Pilots were able to use defined bank management and reversal criteria to accurately track the bank angle commands, and stay within flight performance metrics of landing accuracy, g-loads, and propellant consumption, suggesting that the pilotability of Orion under manual control is both achievable and provides adequate trajectory performance with acceptable levels of pilot effort. Another significant result of these analyses is the applicability of flying a complex entry task under high speed entry flight conditions relevant to the next generation Multi Purpose Crew Vehicle return from Mars and Near Earth Objects.

  12. Evolved atmospheric entry corridor with safety factor (United States)

    Liang, Zixuan; Ren, Zhang; Li, Qingdong


    Atmospheric entry corridors are established in previous research based on the equilibrium glide condition which assumes the flight-path angle to be zero. To get a better understanding of the highly constrained entry flight, an evolved entry corridor that considers the exact flight-path angle is developed in this study. Firstly, the conventional corridor in the altitude vs. velocity plane is extended into a three-dimensional one in the space of altitude, velocity, and flight-path angle. The three-dimensional corridor is generated by a series of constraint boxes. Then, based on a simple mapping method, an evolved two-dimensional entry corridor with safety factor is obtained. The safety factor is defined to describe the flexibility of the flight-path angle for a state within the corridor. Finally, the evolved entry corridor is simulated for the Space Shuttle and the Common Aero Vehicle (CAV) to demonstrate the effectiveness of the corridor generation approach. Compared with the conventional corridor, the evolved corridor is much wider and provides additional information. Therefore, the evolved corridor would benefit more to the entry trajectory design and analysis.

  13. Proposed entry of organization in bilingual glossaries terminology - sign language and brazilian portuguese language

    Directory of Open Access Journals (Sweden)

    Patricia Tuxi


    Full Text Available This work, which is inserted in the research line of Translation and Terminology, presented as an object of study the basic terms used in political and educational discourses that permeate national conference events. In respect to the Law 10436/2002 and Decree 5626/2005 is right for the Deaf have access to information in Brazilian Sign Language - Libras. One way to ensure this right is the presence of translator and interpreter to act in areas with specialized subjects should retain the knowledge of the specific terminology used in different contexts. The current study is based on the methodology for the preparation of dictionaries and glossaries Faulstich (1995. The research follows the approach of Socioterminology and as following: i recognition and identification of the target audience; ii delimitation of the surveyed area; iii collection and organization of data; iv organization glossary and validity test. The search result is the presentation of a proposal for entry of organizing a Terminology Glossary Bilingual facing the conference area that can serve as a reference source and training of translators and interpreters who work in the national conference events.

  14. Proposed entry of organization in bilingual glossaries terminology - sign language and brazilian portuguese language

    Directory of Open Access Journals (Sweden)

    Patricia Tuxi


    Full Text Available This work, which is inserted in the research line of Translation and Terminology, presented as an object of study the basic terms used in political and educational discourses that permeate national conference events. In respect to the Law 10436/2002 and Decree 5626/2005 is right for the Deaf have access to information in Brazilian Sign Language - Libras. One way to ensure this right is the presence of translator and interpreter to act in areas with specialized subjects should retain the knowledge of the specific terminology used in different contexts. The current study is based on the methodology for the preparation of dictionaries and glossaries Faulstich (1995. The research follows the approach of Socioterminology and as following: i recognition and identification of the target audience; ii delimitation of the surveyed area; iii collection and organization of data; iv organization glossary and validity test. The search result is the presentation of a proposal for entry of organizing a Terminology Glossary Bilingual facing the conference area that can serve as a reference source and training of translators and interpreters who work in the national conference events.

  15. Enhancement of motor learning by focal intermittent theta burst stimulation (iTBS) of either the primary motor (M1) or somatosensory area (S1) in healthy human subjects. (United States)

    Platz, Thomas; Adler-Wiebe, Marija; Roschka, Sybille; Lotze, Martin


    Motor rehabilitation after brain damage relies on motor re-learning as induced by specific training. Non-invasive brain stimulation (NIBS) can alter cortical excitability and thereby has a potential to enhance subsequent training-induced learning. Knowledge about any priming effects of NIBS on motor learning in healthy subjects can help to design targeted therapeutic applications in brain-damaged subjects. To examine whether complex motor learning in healthy subjects can be enhanced by intermittent theta burst stimulation (iTBS) to primary motor or sensory cortical areas. Eighteen young healthy subjects trained eight different arm motor tasks (arm ability training, AAT) once a day for 5 days using their left non-dominant arm. Except for day 1 (baseline), training was performed after applying an excitatory form of repetitive transcranial magnetic stimulation (iTBS) to either (I) right M1 or (II) S1, or (III) sham stimulation to the right M1. Subjects were randomly assigned to conditions I, II, or III. A principal component analysis of the motor behaviour data suggested eight independent motor abilities corresponding to the 8 trained tasks. AAT induced substantial motor learning across abilities with generalisation to a non-trained test of finger dexterity (Nine-Hole-Peg-Test, NHPT). Participants receiving iTBS (to either M1 or S1) showed better performance with the AAT tasks over the period of training compared to sham stimulation as well as a bigger improvement with the generalisation task (NHPT) for the trained left hand after training completion. Priming with an excitatory repetitive transcranial magnetic stimulation as iTBS of either M1 or S1 can enhance motor learning across different sensorimotor abilities.

  16. Macropinocytosis is the entry mechanism of amphotropic murine leukemia virus. (United States)

    Rasmussen, Izabela; Vilhardt, Frederik


    The entry mechanism of murine amphotropic retrovirus (A-MLV) has not been unambiguously determined. We show here that A-MLV is internalized not by caveolae or other pinocytic mechanisms but by macropinocytosis. Thus, A-MLV infection of mouse embryonic fibroblasts deficient for caveolin or dynamin, and NIH 3T3 cells knocked down for caveolin expression, was unaffected. Conversely, A-MLV infection of NIH 3T3 and HeLa cells was sensitive to amiloride analogues and actin-depolymerizing drugs that interfere with macropinocytosis. Further manipulation of the actin cytoskeleton through conditional expression of dominant positive or negative mutants of Rac1, PAK1, and RhoG, to increase or decrease macropinocytosis, similarly correlated with an augmented or inhibited infection with A-MLV, respectively. The same experimental perturbations affected the infection of viruses that use clathrin-coated-pit endocytosis or other pathways for entry only mildly or not at all. These data agree with immunofluorescence studies and cryo-immunogold labeling for electron microscopy, which demonstrate the presence of A-MLV in protrusion-rich areas of the cell surface and in cortical fluid phase (dextran)-filled macropinosomes, which also account for up to a half of the cellular uptake of the cell surface-binding lectin concanavalin A. We conclude that A-MLV use macropinocytosis as the predominant entry portal into cells. Binding and entry of virus particles into mammalian cells are the first steps of infection. Understanding how pathogens and toxins exploit or divert endocytosis pathways has advanced our understanding of membrane trafficking pathways, which benefits development of new therapeutic schemes and methods of drug delivery. We show here that amphotropic murine leukemia virus (A-MLV) pseudotyped with the amphotropic envelope protein (which expands the host range to many mammalian cells) gains entry into host cells by macropinocytosis. Macropinosomes form as large, fluid

  17. Heat stress in urban areas: Indoor and outdoor temperatures in different urban structure types and subjectively reported well-being during a heat wave in the city of Leipzig

    Directory of Open Access Journals (Sweden)

    Ulrich Franck


    Full Text Available Climate projections for Leipzig suggest elevated minimum and maximum temperatures as well as more frequent days with high temperatures. Hence, climate change is threatening human well-being and health. People spend the majority of their time indoors. Therefore, indoor temperatures (especially during the night are of special importance with respect to well-being and health. Indoor air temperature depends on outdoor air temperatures, but is for example modified by type of urban structure, housing area, and may be also influenced by differences in the behavior of the inhabitants. Especially in cities, outdoor air temperatures depend on urban structure e.g. housing density, building arrangement, unpaved areas, types of urban structures, urban green, and other factors. Hence, the questions arise how types of urban structures are related to inner-urban temperature differences and how outdoor air temperatures influence indoor temperatures in dependence on urban housing conditions. This work is a part of a pilot study conducted during the summer 2010 which gathered data from remote sensing, mobile measurements, stationary measurements of air temperatures and relative humidity in areas with different housing structures, and of indoor as well as outdoor temperatures in occupied apartments. Household-survey data reported the subjective perception of heat stress. The study resulted in rather complex relationships between type of housing areas, indoor and outdoor temperatures, morning and evening temperatures, indoor and outdoor temperatures as well as subjective heat perception. Green spaces and types of residential areas are related to air temperatures. More green resulted in lower temperatures. Temperatures have a tendency to increase with increasing story number and are significantly higher in the top floor. An indoor heat island effect corresponding to the outdoor effect could be shown for the homes: Distance to city center is a predicting variable for

  18. Entries for the UK Business Plan Competition 2003

    CERN Multimedia


    PPARC is supporting the Research Councils' Business Plan Competition 2003, for which outline (one page) entries should be submitted by 31.1.03. The competition is open to CERN staff and visiting academics from UK establishments. The main condition on entry for CERN staff is that there should be intent to commercialise the technology in the UK. Postgraduates, postdocs and academic staff who have a business idea arising from their research and want to develop this further are encouraged to participate. There is a £25,000 first prize and advice and training along the way. The first step is simple - just prepare a one page summary of your business idea - without giving away any potential business secrets and fill in your details on the short application form. The training element will provide a comprehensive coverage on the issues you need to know about with case studies and special sessions on specific issues of relevance to different research areas. Staff from CERN EP division submitted an entry last year, w...

  19. Acquisition entry strategy of Nordic Multinational Enterprises in China: An analysis of key determinants

    DEFF Research Database (Denmark)

    Arslan, Ahmad; Wang, Yi


    This article addresses the key determinants of acquisition entry strategy (i.e., the choice between full versus partial acquisition) of Nordic multinational enterprises (MNEs) in China. Although general establishment and entry mode strategies have been a highly researched area in international...... business studies, acquisitions as a specific entry strategy and its different aspects have been scarcely researched. Therefore, the current study aims to fill the gap in literature by analyzing determinants of acquisition entry strategy based on three important theoretical bases: transaction cost economics....... The empirical results show that high target country experience, high cultural distance, high level of product diversification, and subsidiary location in institutionally developed and open cities of China were positively associated with choice of full acquisitions by Nordic MNEs. On the other hand, high...

  20. Obtaining orthotropic elasticity tensor using entries zeroing method. (United States)

    Gierlach, Bartosz; Danek, Tomasz


    A generally anisotropic elasticity tensor obtained from measurements can be represented by a tensor belonging to one of eight material symmetry classes. Knowledge of symmetry class and orientation is helpful for describing physical properties of a medium. For each non-trivial symmetry class except isotropic this problem is nonlinear. A common method of obtaining effective tensor is a choosing its non-trivial symmetry class and minimizing Frobenius norm between measured and effective tensor in the same coordinate system. Global optimization algorithm has to be used to determine the best rotation of a tensor. In this contribution, we propose a new approach to obtain optimal tensor, with the assumption that it is orthotropic (or at least has a similar shape to the orthotropic one). In orthotropic form tensor 24 out of 36 entries are zeros. The idea is to minimize the sum of squared entries which are supposed to be equal to zero through rotation calculated with optimization algorithm - in this case Particle Swarm Optimization (PSO) algorithm. Quaternions were used to parametrize rotations in 3D space to improve computational efficiency. In order to avoid a choice of local minima we apply PSO several times and only if we obtain similar results for the third time we consider it as a correct value and finish computations. To analyze obtained results Monte-Carlo method was used. After thousands of single runs of PSO optimization, we obtained values of quaternion parts and plot them. Points concentrate in several points of the graph following the regular pattern. It suggests the existence of more complex symmetry in the analyzed tensor. Then thousands of realizations of generally anisotropic tensor were generated - each tensor entry was replaced with a random value drawn from normal distribution having a mean equal to measured tensor entry and standard deviation of the measurement. Each of these tensors was subject of PSO based optimization delivering quaternion for optimal


    Indian Academy of Sciences (India)


    sensor for methanol determination in the gas phase. 703. Electrochemically active surface area. Platinum-carbon black-titanium dioxide nanocompo- site electrocatalysts for fuel cell applications. 655. Electrochemistry. Synthesis, spectroscopic and redox properties of the mononuclear Ni. II. , Ni. II. (BPh2)2 containing (B–C) ...


    Indian Academy of Sciences (India)

    protected areas of Rajasthan, India. 467. Geochemistry. Geochemical constraints on the evolution of mafic and felsic rocks in the Bathani volcanic and volcano- sedimentary sequence of Chotanagpur Granite Gneiss. Complex. 959. Identification and characterization of tsunami deposits off southeast coast of India from the ...

  3. Workforce re-entry for Japanese unemployed dental hygienists. (United States)

    Usui, Y; Miura, H


    The aim of this study was to define the profile of unemployed dental hygienists who could be enticed to re-enter the workforce and the factors that could facilitate their re-entry into the dental field in Japan. The questionnaire was mailed with a postage-paid return envelope to a sample of 3095 licensed dental hygienists. A 50.4% response rate (S = 1477) was observed. The rate of working dental hygienists was 60.3% (n = 891), and of unemployed dental hygienists was 39.7% (n = 586). Of the latter, 31.9% (n = 187) stated intentions of returning to the workplace. The unemployed dental hygienists seeking employment were more often married and had more children, compared with working dental hygienists currently. This group also had significantly fewer total service years. Moreover, only 11.96% of them belonged to the Japan Dental Hygienists' Association, and 41.3% of those attended training workshops. According to their response, they perceived their top three major barriers to re-entry as 'lack sufficient dental hygiene skill', 'child rearing' and 'poor working atmosphere'. 'Flexibility in the work schedule' and 'location' were the most important factors for re-entry from their perspective. There were not many dental hygienists hoping to return to the dental field. The findings suggested that strategies to encourage non-practicing dental hygienists to re-entry should be emphasized in the areas of a flexible working atmosphere, easy access to information on how to return to practice and guidance on how to maintain professionalism during inactivity. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  4. ELECTRA © Launch and Re-Entry Safety Analysis Tool (United States)

    Lazare, B.; Arnal, M. H.; Aussilhou, C.; Blazquez, A.; Chemama, F.


    French Space Operation Act gives as prime objective to National Technical Regulations to protect people, properties, public health and environment. In this frame, an independent technical assessment of French space operation is delegated to CNES. To perform this task and also for his owns operations CNES needs efficient state-of-the-art tools for evaluating risks. The development of the ELECTRA© tool, undertaken in 2007, meets the requirement for precise quantification of the risks involved in launching and re-entry of spacecraft. The ELECTRA© project draws on the proven expertise of CNES technical centers in the field of flight analysis and safety, spaceflight dynamics and the design of spacecraft. The ELECTRA© tool was specifically designed to evaluate the risks involved in the re-entry and return to Earth of all or part of a spacecraft. It will also be used for locating and visualizing nominal or accidental re-entry zones while comparing them with suitable geographic data such as population density, urban areas, and shipping lines, among others. The method chosen for ELECTRA© consists of two main steps: calculating the possible reentry trajectories for each fragment after the spacecraft breaks up; calculating the risks while taking into account the energy of the fragments, the population density and protection afforded by buildings. For launch operations and active re-entry, the risk calculation will be weighted by the probability of instantaneous failure of the spacecraft and integrated for the whole trajectory. ELECTRA©’s development is today at the end of the validation phase, last step before delivery to users. Validation process has been performed in different ways: numerical application way for the risk formulation; benchmarking process for casualty area, level of energy of the fragments entries and level of protection housing module; best practices in space transportation industries concerning dependability evaluation; benchmarking process for

  5. Experience at the Los Alamos Meson Physics Facility with the use of alloy Inconel 718 as an enclosure for a beam degrader and as a proton beam entry window

    Energy Technology Data Exchange (ETDEWEB)

    Sommer, W.F.; Ferguson, P.D.; Brown, R.D.; Cedillo, C.M.; Zimmerman, E.


    Operation of the Los Alamos Meson Physics Facility (LAMPF) began in 1972 and continues at present. An injector delivers protons to a 0.8 kin long linear accelerator which produces a particle energy of 800 MeV; the protons are then transported to a variety of experimental areas. The proton beam is transported in a vacuum tube, controlled and bent by electromagnets. The highest intensity beam, at a maximum level of 1 mA, is delivered to the experimental area designated as Area A. At the end of the experimental area, the beam is transported through an interface between beamline vacuum and one atmosphere air pressure. This interface is made of metal and is generally referred to as a beam entry window. At LAMPF, after the beam has exited the vacuum tube, it becomes incident on a number of experiments or ``targets.`` These include capsules for radiation damage studies, a beam ``degrader`` for the long-term neutrino experiment, and as many nine targets in the Isotope Production (IP) stringer system used to produce medically significant isotopes. Following the IP system is a beam stop used for the purpose its name implies. The beam stop also contains a beam entry window, whose purpose is to separate the 250 psig water cooling environment from I atmosphere of air. The beam entry window, the beam degrader, and the beam stop window are made of alloy Inconel 718, have endured a lengthy irradiation service time at LAMPF, and are the subject of this report.

  6. Financial Performance of Entry Mode Decisions

    DEFF Research Database (Denmark)

    Boyd, Britta; Dyhr Ulrich, Anna Marie; Hollensen, Svend


    Based on a survey of 170 Danish SMEs the paper examines influences on entry mode choices and the financial outcome of these decisions. The main research objectives are divided into two steps: Step 1: To determine the factors influencing the choice of foreign entry modes by Danish companies. Step ...... and implications are provided for companies willing to invest more into foreign markets in order to achieve a higher degree of control and better financial results.......Based on a survey of 170 Danish SMEs the paper examines influences on entry mode choices and the financial outcome of these decisions. The main research objectives are divided into two steps: Step 1: To determine the factors influencing the choice of foreign entry modes by Danish companies. Step 2......: To determine the relationship between the choice of entry mode and export performance, measured in terms of financial outcome. Drawing from transaction cost theory the authors develop and test a model where different factors affect the level of control chosen by the parent company. This study contributes...

  7. Atmospheric Entry Studies for Venus Missions: 45 Sphere-Cone Rigid Aeroshells and Ballistic Entries (United States)

    Prabhu, Dinesh K.; Spilker, Thomas R.; Allen, Gary A., Jr.; Hwang, Helen H.; Cappuccio, Gelsomina; Moses, Robert W.


    The present study considers direct ballistic entries into the atmosphere of Venus using a 45deg sphere-cone rigid aeroshell, a legacy shape that has been used successfully in the past in the Pioneer Venus Multiprobe Mission. For a number of entry mass and heatshield diameter combinations (i.e., various ballistic coefficients) and entry velocities, the trajectory space in terms of entry flight path angles between skip out and -30deg is explored with a 3DoF trajectory code, TRAJ. From these trajectories, the viable entry flight path angle space is determined through the use of mechanical and thermal performance limits on the thermal protection material and science payload; the thermal protection material of choice is entry-grade carbon phenolic, for which a material thermal response model is available. For mechanical performance, a 200 g limit is placed on the peak deceleration load experienced by the science instruments, and 10 bar is assumed as the pressure limit for entry-grade carbon-phenolic material. For thermal performance, inflection points in the total heat load distribution are used as cut off criteria. Analysis of the results shows the existence of a range of critical ballistic coefficients beyond which the steepest possible entries are determined by the pressure limit of the material rather than the deceleration load limit.

  8. Curriculum Differentiation and Social Inequality in Higher Education Entry in Scotland and Ireland (United States)

    Iannelli, Cristina; Smyth, Emer; Klein, Markus


    This paper examines the relative importance of upper secondary subject choice and attainment in explaining social inequalities in access to higher education (HE) in Scotland and Ireland. These two countries differ in the extent of curriculum differentiation, in the degree of standardisation in school examination and in HE entry criteria. In…

  9. Regulation of Entry and the Distortion of Industrial Organization


    Raymond Fisman; Virginia Sarria-Allende


    We study the distortions to industrial organization caused by entry regulation. We take advantage of heterogeneity across industries in their natural barriers and growth opportunities to examine whether some industries are differentially affected by country-level entry regulation. In industries with high natural entry barriers, entry regulation has little impact on the quantity and average size of firms in an industry. By contrast, in industries with low natural entry barriers, countries with...

  10. 19 CFR 141.56 - Single entry summary for multiple transportation entries consigned to the same consignee. (United States)


    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Single entry summary for multiple transportation entries consigned to the same consignee. 141.56 Section 141.56 Customs Duties U.S. CUSTOMS AND BORDER... transportation entries consigned to the same consignee. (a) Requirement. Port directors may accept one entry...

  11. Modes and orders of market entry

    DEFF Research Database (Denmark)

    Ulhøi, John Parm


    This paper focuses on the initial questions of how and when to enter a market from the perspective of a firm. By entry mode is meant a firm’s strategy (innovation or imitation) for entering the market in response to environmental changes. Entry order refers to the related issue of market timing...... strategies are more ambiguous. Based on a corporate technology and innovation strategy perspective, the paper reconceptualises and extends existing modes and orders of market entry, and in particular clarifies the ambiguity associated with imitative strategies. Four distinct imitator strategies...... are identified. The paper closes with a brief discussion of limitations, avenues for future research, and implications for managers and affected policymakers....

  12. CELEBRATING OUR SUBJECTIVITY: Research as Lived Experience

    African Journals Online (AJOL)

    The area is a small island of humanity in a sea of industry and freeways. Bordered on all fronts by built environments that serve as barriers to isolate it from other .... school hell rings at the end of the day I drive to my own place, far away fhlm the smoke stacks, the freeway and the struggles (Personal. Journal entry September ...

  13. Form, its meaning, and dictionary entries

    Directory of Open Access Journals (Sweden)

    Violetta Koseska-Toszewa


    It is worth stressing that distinguishing between the form and its meaning in comparing the material 6 languages belonging to three different groups of Slavic languages (as is the case in the MONDILEX Project will allow us to avoid numeorus substantiva mistakes and erroneous conclusions. Hence dictionary entries should be verified and made uniform in that respect before they are “digitalized”... Distinction between the form and its meaning in a dictionary entry is fully possible, as shown by works of Z. Saloni (2002 and A.Przepiórkowski (2008.

  14. [Variability of physician judgements in school entry examinations]. (United States)

    Geyer, S; Wedegärtner, F


    Data from school entry examinations were used for studying the variability of judgements between physicians performing the examinations. Two diagnoses were subject to examination: 1) Obesity, because an external criterion was available for this one. The medical classifications were compared with automated classifications using an external criterion. 2) Language anomalies, because these are the most frequent diagnoses. No external criterion had been available, thus differences within the group of examining physicians were considered. Data from all school entry examinations performed in the city of Hannover between 1998 and 2001 were used. Altogether 14 physicians were involved, but due to low case numbers the data of two had to be omitted. The analyses are based on 18,303 datasets. For obesity the agreement rates between physicians' and automatically generated diagnoses were ascertained by calculating sensitivity and specificity. Comparisons of differences between physicians with respect to chances of getting a diagnosis were performed using logistic regression. The sensitivity of classifying body weights above the 75 (th) percentile correctly was 0.64 over all years of observation. The respective sensitivity of classifying children with body weights above the 97 (th) percentile was 0.70. Considerable differences over the four years of observation occurred. For performing logistic regressions, the diagnoses of the physician with the smallest difference from an external criterion were used as standard of comparison. The diagnoses of the physician with the largest difference yielded an OR=0.08. The overall variability within the group of examining physicians was large. With respect to language anomalies, although considerable, the within-group differences were smaller. The largest odds ratio in this case was OR=0.40. Diagnoses from school entry examinations vary according to the physicians involved. Thus the data should not be used for epidemiological studies. In

  15. Continuous Aerodynamic Modelling of Entry Shapes

    NARCIS (Netherlands)

    Dirkx, D.; Mooij, E.


    During the conceptual design phase of a re-entry vehicle, the vehicle shape can be varied and its impact on performance evaluated. To this end, the continuous modeling of the aerodynamic characteristics as a function of the shape is useful in exploring the full design space. Local inclination

  16. Female entrepreneurial networks and foreign market entry

    DEFF Research Database (Denmark)

    Rosenbaum, Gitte Ohrt


    The purpose of this paper is to explore the role of networks in the 116 foreign market entries (FMEs) of women-owned small businesses. A multiple case study based on semi-structured interviews with eight female entrepreneurs in the Danish fashion design industry. The results show that contrary...

  17. Entry modes of European firms in Vietnam

    Directory of Open Access Journals (Sweden)

    Daniel Simonet


    Full Text Available Purpose: The purpose of the paper is to explore the entry modes of EU firms setting up operations in Vietnam. Design/methodology/approach: we use a case study approach on Haymarket, Cadbury, Creative Education, Fairchild, Aventis and Artemisinin and Farming International using interviews from managerial professionals in Vietnam. Findings: Despite the fact that Vietnam has been opening up for more than 20 years, licensing is the preferred entry mode because of the risks involved in venturing with local firms; that preference signals a low level commitment and a high perception of risk and state interference. In line with Vietnam transition to state - rather than private market - capitalism, a foreign company opting for a joint-venture will do so with a state-owned rather than privately-owned company. The choice of a subsidiary can be explained by the lack of trust in partners and institutions, not by improvement in the socio-political environment. Limitations: In determining the entry mode strategy, the paper focuses on the Uppsala school’s “psychic distance” (e.g. cultural distance, lack of trust rather than on firm-specific advantages (Rugman, 1980; 2006. Key-words: international entry mode; emerging markets; subsidiary; joint-venture; India; Vietnam

  18. Internet portals as portfolios of entry options

    NARCIS (Netherlands)

    Perotti, E.C.; Rossetto, S.


    We investigate the valuation of platform investment, such as a software operating system or an Internet portal WebPage. Platform investment is the creation of an innovative distribution and production infrastructure, which increases access to customers; as a result it reduces entry costs in related

  19. Flavivirus cell entry and membrane fusion

    NARCIS (Netherlands)

    Smit, Jolanda M.; Moesker, Bastiaan; Rodenhuis-Zybert, Izabela; Wilschut, Jan

    Flaviviruses, such as dengue virus and West Nile virus, are enveloped viruses that infect cells through receptor-mediated endocytosis and fusion from within acidic endosomes. The cell entry process of flaviviruses is mediated by the viral E glycoprotein. This short review will address recent

  20. Radiation and critical shocks in atmospheric entry

    Energy Technology Data Exchange (ETDEWEB)

    Canavan, G.H.


    Sub- and supercritical shock waves are produced during atmospheric entry. The radiation efficiency of the former increases strongly with velocity and altitude; that of the latter increases with altitude, but decreases with supercritical velocities. These efficiencies shift the region of maximum radiation one to two scale heights higher and decrease overall radiation efficiency.

  1. Flavivirus cell entry and membrane fusion

    NARCIS (Netherlands)

    Smit, Jolanda M.; Moesker, Bastiaan; Rodenhuis-Zybert, Izabela; Wilschut, Jan


    Flaviviruses, such as dengue virus and West Nile virus, are enveloped viruses that infect cells through receptor-mediated endocytosis and fusion from within acidic endosomes. The cell entry process of flaviviruses is mediated by the viral E glycoprotein. This short review will address recent

  2. Correlation Between Entry Requirements and Academic ...

    African Journals Online (AJOL)

    In this study, the investigator examines the correlation between entry requirements and academic performance of undergraduate students at the University of Buea. The quality of performance on the Cameroon General Certificate Examination at the Advanced Level is the predictor while the criterion is the cumulative grade ...

  3. Foreign entry, cultural barriers and learning

    NARCIS (Netherlands)

    H.G. Barkema (Harry); J.H.J. Bell (John); J.M.E. Pennings


    textabstractThis paper examines the longevity of foreign entries. Hypotheses are developed on the mode (start-ups vs. acquisitions) and ownership structure (wholly owned vs. joint ventures) in relation to cultural distance. The hypotheses are tested within a framework of organizational learning,

  4. 19 CFR 159.7 - Rewarehouse entries. (United States)


    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Rewarehouse entries. 159.7 Section 159.7 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY.... When any of the following types of merchandise are withdrawn from warehouse for transportation to...

  5. Business entry and window of opportunity

    DEFF Research Database (Denmark)

    Tegtmeier, Silke; Kurczewska, Agnieszka


    This paper explores the nascence period - the time between idea generation and business entry -among women entrepreneurs with a graduate degree. To address this research problem and to better understand the specifics of a window of opportunity, we combine selected theories of human and social...

  6. Mission Sizing and Trade Studies for Low Ballistic Coefficient Entry Systems to Venus (United States)

    Dutta, Soumyo; Smith, Brandon; Prabhu, Dinesh; Venkatapathy, Ethiraj


    The U.S and the U.S.S.R. have sent seventeen successful atmospheric entry missions to Venus. Past missions to Venus have utilized rigid aeroshell systems for entry. This rigid aeroshell paradigm sets performance limitations since the size of the entry vehicle is constrained by the fairing diameter of the launch vehicle. This has limited ballistic coefficients (beta) to well above 100 kg/m2 for the entry vehicles. In order to maximize the science payload and minimize the Thermal Protection System (TPS) mass, these missions have entered at very steep entry flight path angles (gamma). Due to Venus thick atmosphere and the steep-gamma, high- conditions, these entry vehicles have been exposed to very high heat flux, very high pressures and extreme decelerations (upwards of 100 g's). Deployable aeroshells avoid the launch vehicle fairing diameter constraint by expanding to a larger diameter after the launch. Due to the potentially larger wetted area, deployable aeroshells achieve lower ballistic coefficients (well below 100 kg/m2), and if they are flown at shallower flight path angles, the entry vehicle can access trajectories with far lower decelerations (50-60 g's), peak heat fluxes (400 W/cm2) and peak pressures. The structural and TPS mass of the shallow-gamma, low-beta deployables are lower than their steep-gamma, high-beta rigid aeroshell counterparts at larger diameters, contributing to lower areal densities and potentially higher payload mass fractions. For example, at large diameters, deployables may attain aeroshell areal densities of 10 kg/m2 as opposed to 50 kg/m2 for rigid aeroshells. However, the low-beta, shallow-gamma paradigm also raises issues, such as the possibility of skip-out during entry. The shallow-gamma could also increase the landing footprint of the vehicle. Furthermore, the deployable entry systems may be flexible, so there could be fluid-structure interaction, especially in the high altitude, low-density regimes. The need for precision in

  7. Shuttle Entry Imaging Using Infrared Thermography (United States)

    Horvath, Thomas; Berry, Scott; Alter, Stephen; Blanchard, Robert; Schwartz, Richard; Ross, Martin; Tack, Steve


    During the Columbia Accident Investigation, imaging teams supporting debris shedding analysis were hampered by poor entry image quality and the general lack of information on optical signatures associated with a nominal Shuttle entry. After the accident, recommendations were made to NASA management to develop and maintain a state-of-the-art imagery database for Shuttle engineering performance assessments and to improve entry imaging capability to support anomaly and contingency analysis during a mission. As a result, the Space Shuttle Program sponsored an observation campaign to qualitatively characterize a nominal Shuttle entry over the widest possible Mach number range. The initial objectives focused on an assessment of capability to identify/resolve debris liberated from the Shuttle during entry, characterization of potential anomalous events associated with RCS jet firings and unusual phenomenon associated with the plasma trail. The aeroheating technical community viewed the Space Shuttle Program sponsored activity as an opportunity to influence the observation objectives and incrementally demonstrate key elements of a quantitative spatially resolved temperature measurement capability over a series of flights. One long-term desire of the Shuttle engineering community is to calibrate boundary layer transition prediction methodologies that are presently part of the Shuttle damage assessment process using flight data provided by a controlled Shuttle flight experiment. Quantitative global imaging may offer a complementary method of data collection to more traditional methods such as surface thermocouples. This paper reviews the process used by the engineering community to influence data collection methods and analysis of global infrared images of the Shuttle obtained during hypersonic entry. Emphasis is placed upon airborne imaging assets sponsored by the Shuttle program during Return to Flight. Visual and IR entry imagery were obtained with available airborne

  8. Coronaviruses induce entry-independent, continuous macropinocytosis. (United States)

    Freeman, Megan Culler; Peek, Christopher T; Becker, Michelle M; Smith, Everett Clinton; Denison, Mark R


    Macropinocytosis is exploited by many pathogens for entry into cells. Coronaviruses (CoVs) such as severe acute respiratory syndrome (SARS) CoV and Middle East respiratory syndrome CoV are important human pathogens; however, macropinocytosis during CoV infection has not been investigated. We demonstrate that the CoVs SARS CoV and murine hepatitis virus (MHV) induce macropinocytosis, which occurs late during infection, is continuous, and is not associated with virus entry. MHV-induced macropinocytosis results in vesicle internalization, as well as extended filopodia capable of fusing with distant cells. MHV-induced macropinocytosis requires fusogenic spike protein on the cell surface and is dependent on epidermal growth factor receptor activation. Inhibition of macropinocytosis reduces supernatant viral titers and syncytia but not intracellular virus titers. These results indicate that macropinocytosis likely facilitates CoV infection through enhanced cell-to-cell spreading. Our studies are the first to demonstrate virus use of macropinocytosis for a role other than entry and suggest a much broader potential exploitation of macropinocytosis in virus replication and host interactions. Importance: Coronaviruses (CoVs), including severe acute respiratory syndrome (SARS) CoV and Middle East respiratory syndrome CoV, are critical emerging human pathogens. Macropinocytosis is induced by many pathogens to enter host cells, but other functions for macropinocytosis in virus replication are unknown. In this work, we show that CoVs induce a macropinocytosis late in infection that is continuous, independent from cell entry, and associated with increased virus titers and cell fusion. Murine hepatitis virus macropinocytosis requires a fusogenic virus spike protein and signals through the epidermal growth factor receptor and the classical macropinocytosis pathway. These studies demonstrate CoV induction of macropinocytosis for a purpose other than entry and indicate that viruses

  9. Protections for Workers Who Must Enter Pesticide-Treated Areas Early (United States)

    The Worker Protection Standard allows entry into a pesticide-treated area that remains under a restricted-entry interval only in a few narrow work situations. Learn about special protections that must be provided for workers in these situations.

  10. A Choice Prediction Competition for Market Entry Games: An Introduction

    Directory of Open Access Journals (Sweden)

    Ido Erev


    Full Text Available A choice prediction competition is organized that focuses on decisions from experience in market entry games ( and The competition is based on two experiments: An estimation experiment, and a competition experiment. The two experiments use the same methods and subject pool, and examine games randomly selected from the same distribution. The current introductory paper presents the results of the estimation experiment, and clarifies the descriptive value of several baseline models. The experimental results reveal the robustness of eight behavioral tendencies that were documented in previous studies of market entry games and individual decisions from experience. The best baseline model (I-SAW assumes reliance on small samples of experiences, and strong inertia when the recent results are not surprising. The competition experiment will be run in May 2010 (after the completion of this introduction, but they will not be revealed until September. To participate in the competition, researchers are asked to E-mail the organizers models (implemented in computer programs that read the incentive structure as input, and derive the predicted behavior as an output. The submitted models will be ranked based on their prediction error. The winners of the competition will be invited to publish a paper that describes their model.

  11. Foreign Entry Modes Under Institutional Pressures: The Impact of Strategic Resource Seeking and Market Seeking Strategies

    Directory of Open Access Journals (Sweden)

    Manuel Portugal Ferreira


    Full Text Available Multinational corporations (MNCs are subject to the various dimensions of the external institutional environments. Institutional theory suggests that MNCs need to conform to the prevailing rules, norms and procedures of the locations where they operate in order to survive and grow. This means that MNCs need to develop the best possible configuration of strategy-structure for their worldwide operations. Previous research has noted that in these conditions firms may simply seek to follow a referent other. However, MNCs’ specific strategy for a focal foreign operation is likely to determine the entry mode for each host country. In certain circumstances it may be whether MNCs are pursuing a market-seeking strategy or a strategic resource seeking strategy that shapes the entry mode in face of the prevailing institutional pressures. We contribute to the understanding of entry modes into foreign markets as a reflection of a strategic choice that is bound by institutional constraints.

  12. Market Entry Strategies : Case: McDonald's entry on the Russian market


    Karataev, Oleg


    The thesis considers the entry strategy and development of the company McDonald's into international markets. The theoretical aspects of the entry strategy of the company into the international markets. Analyzes the key features of the development of McDonald's in Russia. Investigated the prospects of the company in international markets. In theoretic part there was regarded some important aspects of international strategic management, such as: strategic alternatives, elements and levels o...

  13. Adiamento do ingresso no mercado de trabalho sob o enfoque demográfico: uma análise das regiões metropolitanas brasileiras Aplazamiento del ingreso al mercado laboral bajo el enfoque demográfico: un análisis de las regiones metropolitanas brasileñas Demographic perspectives on delayed labor market entry in metropolitan areas in Brazil

    Directory of Open Access Journals (Sweden)

    Maria Carolina Tomás


    Full Text Available O trabalho analisa o adiamento do ingresso no mercado de trabalho entre jovens, através de duas técnicas demográficas: o método singulate mean age; e tabelas de sobrevivência. A base de dados utilizada foi a Pesquisa Mensal de Emprego (PME, considerando-se as seis regiões metropolitanas estudadas (São Paulo, Belo Horizonte, Salvador, Rio de Janeiro, Porto Alegre e Recife conjuntamente. Os períodos analisados foram 1983 e 2001. Ao final, contatou-se um adiamento maior entre os homens, o que os aproxima do padrão de transição feminino, embora eles continuem entrando mais cedo no mercado de trabalho. Ademais, está ocorrendo uma alteração no padrão etário de inserção, já que houve diminuição no contingente de jovens entrando no mercado de trabalho até os 17 anos.El trabajo analiza el aplazamiento del ingreso al mercado laboral entre jóvenes, a través de dos técnicas demográficas: El método singulate mean age; y tablas de sobrevivencia. La base de datos utilizada fue la Encuesta Mensual de Empleo (PME, considerándose las seis regiones metropolitanas estudiadas (San Pablo, Belo Horizonte, Salvador, Río de Janeiro, Porto Alegre y Recife conjuntamente. Los períodos analizados fueron 1983 y 2001. Al final, se constató un aplazamiento mayor entre los hombres, lo que los aproxima al padrón de transición femenino, aunque éstos continúen entrando más temprano al mercado laboral. Además, está ocurriendo una modificación en el padrón etario de inserción, ya que hubo una disminución en el contingente de jóvenes entrando al mercado laboral hasta los 17 años.The article analyzes late entry into the labor market among Brazilian youth, using two demographic techniques: the singulate mean age, and survival tables. The data basis used is the Monthly Employment Survey (PME carried out and published by the Brazilian Census Office (IBGE. The analysis considers six metropolitan areas (São Paulo, Belo Horizonte, Salvador, Rio

  14. Entry Location and Entry Timing (ELET Decision Model for International Construction Firms

    Directory of Open Access Journals (Sweden)

    Che Maznah Mat Isa


    Full Text Available This paper proposes a model for entry location (EL and entry timing (ET decisions to guide construction firms in accessing targeted international markets.  Neglecting to properly choose the right combination of the entry location and entry timing (ELET decisions can lead to poor performance of the firms’ international ventures.  The sampling frame was from the Malaysian construction firms that have undertaken and completed projects abroad.  Survey questionnaires sent to 115 firms registered with Construction Industry Development Board (CIDB Malaysia, operating in more than 50 countries, achieved a 39.1 per cent response rate. Based on a comprehensive statistical analysis of survey data it was found that the mutually inclusive significant factors that influenced the firms’ ELET decisions were: the firm’s ability to assess market signals and opportunities, international experience, financial capacity, competencies and capabilities (project management, specialist expertise and technology, resources (level of knowledge based on research and development, experience in similar works, financial support from the home country banks, technical complexities of projects and availability of funds for projects.  Hence, the present research builds on and extends the literature on the ELET decisions in a more integrated way. Keywords: Entry location, entry timing, resource-based view, international markets, Malaysian construction firms.

  15. Adaptive Deployable Entry and Placement Technology (ADEPT) Project (United States)

    National Aeronautics and Space Administration — The ADEPT Project is developing a mechanically deployable low-ballistic coefficient aeroshell entry system to perform entry descent landing (EDL) functions for...

  16. Design and Simulation Tools for Planetary Atmospheric Entry Vehicles Project (United States)

    National Aeronautics and Space Administration — Atmospheric entry is one of the most critical phases of flight during planetary exploration missions. During the design of an entry vehicle, experimental and...

  17. Interviews as a Selection Tool for Entry-Level Hospitality Employees. (United States)

    Martin, Lynda


    Responses from human resource professionals in restaurants (n=85) and hotels (n=118) identified critical entry-level job behaviors that might be used in developing behavior-based interviews. The large variety of responses and lack of agreement suggest that clear identification of these behaviors may be an area of weakness in the hospitality…

  18. Anesthesia Recordkeeping: Accuracy of Recall with Computerized and Manual Entry Recordkeeping (United States)

    Davis, Thomas Corey


    Introduction: Anesthesia information management systems are rapidly gaining widespread acceptance. Aggressively promoted as an improvement to manual-entry recordkeeping systems in the areas of accuracy, quality improvement, billing and vigilance, these systems record all patient vital signs and parameters, providing a legible hard copy and…

  19. Checking Questionable Entry of Personally Identifiable Information Encrypted by One-Way Hash Transformation. (United States)

    Chen, Xianlai; Fann, Yang C; McAuliffe, Matthew; Vismer, David; Yang, Rong


    As one of the several effective solutions for personal privacy protection, a global unique identifier (GUID) is linked with hash codes that are generated from combinations of personally identifiable information (PII) by a one-way hash algorithm. On the GUID server, no PII is permitted to be stored, and only GUID and hash codes are allowed. The quality of PII entry is critical to the GUID system. The goal of our study was to explore a method of checking questionable entry of PII in this context without using or sending any portion of PII while registering a subject. According to the principle of GUID system, all possible combination patterns of PII fields were analyzed and used to generate hash codes, which were stored on the GUID server. Based on the matching rules of the GUID system, an error-checking algorithm was developed using set theory to check PII entry errors. We selected 200,000 simulated individuals with randomly-planted errors to evaluate the proposed algorithm. These errors were placed in the required PII fields or optional PII fields. The performance of the proposed algorithm was also tested in the registering system of study subjects. There are 127,700 error-planted subjects, of which 114,464 (89.64%) can still be identified as the previous one and remaining 13,236 (10.36%, 13,236/127,700) are discriminated as new subjects. As expected, 100% of nonidentified subjects had errors within the required PII fields. The possibility that a subject is identified is related to the count and the type of incorrect PII field. For all identified subjects, their errors can be found by the proposed algorithm. The scope of questionable PII fields is also associated with the count and the type of the incorrect PII field. The best situation is to precisely find the exact incorrect PII fields, and the worst situation is to shrink the questionable scope only to a set of 13 PII fields. In the application, the proposed algorithm can give a hint of questionable PII entry

  20. Concepts of papillomavirus entry into host cells. (United States)

    Day, Patricia M; Schelhaas, Mario


    Papillomaviruses enter basal cells of stratified epithelia. Assembly of new virions occurs in infected cells during terminal differentiation. This unique biology is reflected in the mechanism of entry. Extracellularly, the interaction of nonenveloped capsids with several host cell proteins, after binding, results in discrete conformational changes. Asynchronous internalization occurs over several hours by an endocytic mechanism related to, but distinct from macropinocytosis. Intracellular trafficking leads virions through the endosomal system, and from late endosomes to the trans-Golgi-network, before nuclear delivery. Here, we discuss the existing data with the aim to synthesize an integrated model of the stepwise process of entry, thereby highlighting key open questions. Additionally, we relate data from experiments with cultured cells to in vivo results. Copyright © 2013 Elsevier B.V. All rights reserved.

  1. Aurora A, mitotic entry, and spindle bipolarity (United States)

    Liu, Quentin; Ruderman, Joan V.


    The kinase Aurora-A (Aur-A), which is enriched at centrosomes, is required for centrosome maturation and accurate chromosome segregation, and recent work implicates centrosomes as sites where the earliest activation of cyclin B1-cdc2 occurs. Here, we have used Xenopus egg extracts to investigate Aur-A's contribution to cell cycle progression and spindle morphology in the presence or absence of centrosomes. We find that addition of active Aur-A accelerates cdc2 activation and mitotic entry. Depletion of endogenous Aur-A or addition of inactive Aur-A, which lead to monopolar spindles, delays but does not block mitotic entry. These effects on timing and spindle structure do not require the presence of centrosomes or chromosomes. The catalytic domain alone of Aur-A is sufficient to restore spindle bipolarity; additional N-terminal sequences function in mitotic timing. PMID:16581905

  2. Filter for interpretation of fragmentation during entry

    Energy Technology Data Exchange (ETDEWEB)

    Canavan, G.H.


    Objects that fragment cascade and decelerate abruptly, producing short, bright, signatures which can be used to estimate object diameter and speed. Other objects can be incorporated into a generalized fragmentation filter. This note summarizes the results of previous reports on the prediction and inversion of signatures from objects that radiate, ablate, and fragment during entry and uses them to produce models for the parameters of entering objects.

  3. Entry Mistakes, Entrepreneurial Boldness and Optimism


    Brocas, Isabelle; Carrillo, Juan D


    We analyze the investment decision of a population of time inconsistent entrepreneurs who overweight current payoffs relative to future returns. We show that, in order to avoid inefficient procrastination, agents may find it optimal to keep optimistic priors about their chances of success and 'blindly invest'. This explains entrepreneurial boldness and entry mistakes (or an excessive level of investment in the economy) without assuming the existence of boundedly rational, 'intrinsically optim...

  4. Dynamics in car ownership: the role of entry into parenthood

    NARCIS (Netherlands)

    Oakil, A.T.M.; Manting, D.; Nijland, H.


    This study investigates the impact of entry into parenthood on changes in car ownership. If entry into parenthood affects changes in car ownership, then delay or offset of entry into parenthood might also be an important explanation of recent car travel trends of young adults. This study analysed

  5. 31 CFR 337.6 - Conversions to book-entry. (United States)


    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Conversions to book-entry. 337.6... HOUSING ADMINISTRATION DEBENTURES Certificated Debentures § 337.6 Conversions to book-entry. Upon implementation of the book-entry debenture system, to be announced in advance by separate public notice, all new...

  6. 19 CFR 12.11 - Requirements for entry and release. (United States)


    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Requirements for entry and release. 12.11 Section 12.11 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... of arrival for any type of entry except rewarehouse and informal mail entries. Such notice shall be...

  7. Identifying missing dictionary entries with frequency-conserving context models (United States)

    Williams, Jake Ryland; Clark, Eric M.; Bagrow, James P.; Danforth, Christopher M.; Dodds, Peter Sheridan


    In an effort to better understand meaning from natural language texts, we explore methods aimed at organizing lexical objects into contexts. A number of these methods for organization fall into a family defined by word ordering. Unlike demographic or spatial partitions of data, these collocation models are of special importance for their universal applicability. While we are interested here in text and have framed our treatment appropriately, our work is potentially applicable to other areas of research (e.g., speech, genomics, and mobility patterns) where one has ordered categorical data (e.g., sounds, genes, and locations). Our approach focuses on the phrase (whether word or larger) as the primary meaning-bearing lexical unit and object of study. To do so, we employ our previously developed framework for generating word-conserving phrase-frequency data. Upon training our model with the Wiktionary, an extensive, online, collaborative, and open-source dictionary that contains over 100 000 phrasal definitions, we develop highly effective filters for the identification of meaningful, missing phrase entries. With our predictions we then engage the editorial community of the Wiktionary and propose short lists of potential missing entries for definition, developing a breakthrough, lexical extraction technique and expanding our knowledge of the defined English lexicon of phrases.

  8. Re-Entry Point Targeting for LEO Spacecraft using Aerodynamic Drag (United States)

    Omar, Sanny; Bevilacqua, Riccardo; Fineberg, Laurence; Treptow, Justin; Johnson, Yusef; Clark, Scott


    Most Low Earth Orbit (LEO) spacecraft do not have thrusters and re-enter atmosphere in random locations at uncertain times. Objects pose a risk to persons, property, or other satellites. Has become a larger concern with the recent increase in small satellites. Working on a NASA funded project to design a retractable drag device to expedite de-orbit and target a re-entry location through modulation of the drag area. Will be discussing the re-entry point targeting algorithm here.

  9. Entry Descent and Landing Workshop Proceedings. Volume 1; Inflatable Reentry Vehicle Experiment-3 (IRVE-3) Project Overview & Instrumentation (United States)

    Dillman, Robert


    Entry mass at Mars is limited by the payload size that can be carried by a rigid capsule that can fit inside the launch vehicle fairing. Landing altitude at Mars is limited by ballistic coefficient (mass per area) of entry body. Inflatable technologies allow payload to use full diameter of launch fairing, and deploy larger aeroshell before atmospheric interface, landing more payload at a higher altitude. Also useful for return of large payloads from Low Earth Orbit (LEO).

  10. Reflections on design workshops with older adults for touchscreen mobile text entry

    Directory of Open Access Journals (Sweden)

    Andreas Komninos


    Full Text Available On touchscreen devices such as smartphones and tablets, text entry remains key to many tasks and is an important factor in the usability of such devices. The physical and cognitive issues associated with ageing can make the known problems of text entry particularly acute for older adults. Poor usability can present a significant problem for older adults where accessing services and social activities are concerned, both of which have implications for exclusion. In a study of mobile text entry where we aimed to develop novel keyboard layouts to address the particular requirements of this group of users we employed a variety of participatory design techniques. We report on our experiences from employing these methods and the methodological implications for further research in this area.

  11. Practical guidelines for modelling post-entry spread in invasion ecology

    Directory of Open Access Journals (Sweden)

    Hazel Parry


    Full Text Available In this article we review a variety of methods to enable understanding and modelling the spread of a pest or pathogen post-entry. Building upon our experience of multidisciplinary research in this area, we propose practical guidelines and a framework for model development, to help with the application of mathematical modelling in the field of invasion ecology for post-entry spread. We evaluate the pros and cons of a range of methods, including references to examples of the methods in practice. We also show how issues of data deficiency and uncertainty can be addressed. The aim is to provide guidance to the reader on the most suitable elements to include in a model of post-entry dispersal in a risk assessment, under differing circumstances. We identify both the strengths and weaknesses of different methods and their application as part of a holistic, multidisciplinary approach to biosecurity research.

  12. 19 CFR 149.6 - Entry and entry summary documentation and Importer Security Filing submitted via a single... (United States)


    ... Security Filing submitted via a single electronic transmission. 149.6 Section 149.6 Customs Duties U.S... submitted via a single electronic transmission. If the Importer Security Filing is filed pursuant to § 149.2 of this part via the same electronic transmission as entry or entry/entry summary documentation...

  13. Study and Development of a Sub-Orbital Re-Entry Demonstrator (United States)

    Savino, R.

    The Italian and European Space Agencies are supporting a research programme, developed in Campania region by a cluster of industries, research institutes and universities, on a low-cost re-entry capsule, able to return payloads from the ISS to Earth and/or to perform short-duration scientific missions in Low Earth Orbit (LEO). The ballistic capsule is characterized by a deployable, disposable "umbrella-like" heat shield that allows relatively small dimensions at launch and a sufficient exposed surface area in re-entry conditions, reducing the ballistic coefficient and leading to acceptable heat fluxes, mechanical loads and final descent velocity. ESA is supporting a preliminary study to develop a flight demonstrator of the capsule to be embarked as a secondary payload onboard a sub-orbital sounding rocket. The deployable thermal protection system concept may be applied to future science and robotic exploration mission requiring planetary entry and, possibly also to missions in the framework of Human Space flight, requiring planetary entry or re-entry. The technology offers also an interesting potential for aerobraking, aerocapture and for de-orbiting. This paper summarizes the results of these activities, which are being more and more refined as the work proceeds, including the definition and analysis of the mission scenario, the aerodynamic, aerothermodynamic, mechanical and structural analyses and the technical definition of avionics, instrumentation and main subsystems.

  14. Exporting Complex Digital Products: Motives and Entry Modes

    DEFF Research Database (Denmark)

    Rask, Morten

    When the product is digital, it will most often be distributed directly to the customer through the Internet, and therefore the entry modes, considered in this paper, are different flavors of the entry mode called direct export: Virtual export channel are generally understood as the entry mode...... for digital product providers. However other types of entry modes like what wee call direct digital export with F2F-sales, direct digital export with F2F-support and virtual sales subsidiary are entry modes that respond to a higher degree of pre- and after-sales complexity....

  15. Exporting Complex Digital Products: Motives and Entry Modes

    DEFF Research Database (Denmark)

    Rask, Morten


    When the product is digital, it will most often be distributed directly to the customer through the Internet, and therefore, the entry modes, considered in this paper, are different flavors of the entry mode called direct export: virtual export channel is generally understood as the entry mode...... for digital product providers. However, other types of entry modes like what we call direct digital export with F2F-sales, direct digital export with F2F-support, and virtual sales subsidiary are entry modes that respond to a higher degree of pre- and postsales complexity....

  16. Small-molecule HIV-1 entry inhibitors targeting gp120 and gp41: a patent review (2010-2015). (United States)

    Li, Wen; Lu, Lu; Li, Weihua; Jiang, Shibo


    It is essential to discover and develop small-molecule HIV-1 entry inhibitors with suitable pharmaceutical properties. Areas covered: We review the development of small-molecule HIV-1 entry inhibitors as evidenced in patents, patent applications, and related research articles published between 2010 and 2015. Expert opinion: HIV-1 Env gp120 and gp41 are important targets for development of HIV-1 entry inhibitors. The Phe43 pocket in gp120 and the highly conserved hydrophobic pocket on gp41 NHR-trimer are important targets for identification of HIV-1 attachment and fusion inhibitors, respectively. Compounds that bind to Phe43 pocket can block viral gp120 binding to CD4 on T cells, thus inhibiting HIV-1 attachment. However, most compounds targeting Phe43 pocket identified so far are HIV-1 entry agonists with the ability to enhance infectivity of HIV-1 in CD4-negative cells. Therefore, it is essential to identify HIV-1 entry antagonist-based HIV-1 attachment/entry inhibitors. Compounds binding to the gp41 hydrophobic pocket may inhibit CHR binding to the gp41 NHR trimer, thus blocking six-helix bundle formation and gp41-mediated virus-cell fusion. However, most lead compounds targeting this pocket have low potency, possibly because the pocket is too big or too deep. Therefore, it is necessary to identify other pockets in gp41 for developing HIV-1 fusion/entry inhibitors.

  17. Competitive Dynamics of Market Entry: Scale and Survival

    Directory of Open Access Journals (Sweden)

    John W. UPSON


    Full Text Available Market entry is the essence of strategy and is largely viewed as a dichotomous event: entry or no entry. What has not been acknowledged is the uniqueness of each market entry. Our study highlights the scale of market entry in the context of multipoint competition. We assert that entry scale varies based on the risk of market incumbent retaliation. Theory suggests that when risk associated with retaliation are low, firms enter with large scale and when associated risks are high, firms enter with low scale. Further, survival is viewed as dependent on following theory. We argue and find supporting evidence that firms behave in the opposite manner and do so to their own benefit, thereby revealing a unique discrepancy between theory and practice among 75 product market entries by 27 firms.

  18. Assessment of the ATV-1 Re-Entry Observation Campaign for Future Re-Entry Missions (United States)

    Lips, T.; Lohle, S.; Marynowsky, T.; Rees, D.; Stenbeak-Nielsen, H. C.; Beks, M. L.; Hatton, J.


    This paper summarizes the midterm results of the currently ongoing ESA study “Assessment of the ATV-1 Reentry Observation Campaign for Future Re-entry Missions”. The primary objective of this study is to investigate the data obtained during a joint ESA/NASA airborne observation campaign of the destructive re-entry of ATV-1 Jules Verne which occurred on September 29, 2008. The presented results are focused on spectroscopic fragment characterization(material identification), frame-by-frame fragment tracking(manual and automatic) for various video recordings, 3D triangulation of the tracked fragments, and fragment propagation until complete demise or ground impact, including the actual size and location of the ATV-1 debris footprint. Fragment propagation analyses comprise also the derivation of aerodynamic fragment properties and potential delta velocities. These parameters are of high importance for the re-entry safety analysis for ATV-2 Johannes Kepler.

  19. The campaigning soldier: Vitellius’ entry into Rome

    Directory of Open Access Journals (Sweden)

    A. T. Fear


    Full Text Available Tacitus’ account of Vitellius’ triumphal entry into Rome is used by the author to underline his disapproval of this emperor. However the historian’s description of the Vitellian army has often been seen as positive and in sharp contrast to that given to the emperor himself. This article attempts to show that on close inspection Tacitus’ account is equally hostile to the emperor’s troops and that his disapproval is reinforced by his dwelling upon the colour of their uniforms and the varied associations this would have had in the Roman mind.

  20. PDBsum: Structural summaries of PDB entries. (United States)

    Laskowski, Roman A; Jabłońska, Jagoda; Pravda, Lukáš; Vařeková, Radka Svobodová; Thornton, Janet M


    PDBsum is a web server providing structural information on the entries in the Protein Data Bank (PDB). The analyses are primarily image-based and include protein secondary structure, protein-ligand and protein-DNA interactions, PROCHECK analyses of structural quality, and many others. The 3D structures can be viewed interactively in RasMol, PyMOL, and a JavaScript viewer called 3Dmol.js. Users can upload their own PDB files and obtain a set of password-protected PDBsum analyses for each. The server is freely accessible to all at: © 2017 The Protein Society.

  1. Radon entry into a simple test structure

    DEFF Research Database (Denmark)

    Andersen, C.E.; Søgaard-Hansen, J.; Majborn, B.


    in the cylinder and in selected locations in the soil. In this paper, the test structure is described, and initial results concerning the transport of soil gas and radon under steady-state conditions are reported. It is found that the soil in the vicinity of the structure is partially depleted with respect......A simple test structure for studies of radon entry into houses has been constructed at a field site at Riso National Laboratory. It consists of a 40 1, stainless-steel cylinder placed in a 0.52 m deep quadratic excavation with a side length of 2.4 m. The excavation is lined with an airtight...

  2. Inhibition of enterovirus 71 entry by transcription factor XBP1

    Energy Technology Data Exchange (ETDEWEB)

    Jheng, Jia-Rong; Lin, Chiou-Yan [Department of Biochemistry and Research Center for Emerging Viral Infections, Chang Gung University, 259 Wen-Hwa First Road, Kweishan, Taoyuan 333, Taiwan (China); Horng, Jim-Tong, E-mail: [Department of Biochemistry and Research Center for Emerging Viral Infections, Chang Gung University, 259 Wen-Hwa First Road, Kweishan, Taoyuan 333, Taiwan (China); Lau, Kean Seng [Department of Biochemistry and Research Center for Emerging Viral Infections, Chang Gung University, 259 Wen-Hwa First Road, Kweishan, Taoyuan 333, Taiwan (China)


    Highlights: Black-Right-Pointing-Pointer IRE1 was activated but no XBP1 splicing was detected during enterovirus 71 infection. Black-Right-Pointing-Pointer XBP1 was subject to translational shutoff by enterovirus 71-induced eIF4G cleavage. Black-Right-Pointing-Pointer The uptake of UV-irradiated virus was decreased in XBP1-overexpressing cells. -- Abstract: Inositol-requiring enzyme 1 (IRE1) plays an important role in the endoplasmic reticulum (ER), or unfolded protein, stress response by activating its downstream transcription factor X-box-binding protein 1 (XBP1). We demonstrated previously that enterovirus 71 (EV71) upregulated XBP1 mRNA levels but did not activate spliced XBP1 (XBP1s) mRNA or its downstream target genes, EDEM and chaperones. In this study, we investigated further this regulatory mechanism and found that IRE1 was phosphorylated and activated after EV71 infection, whereas its downstream XBP1s protein level decreased. We also found that XBP1s was not cleaved directly by 2A{sup pro}, but that cleavage of eukaryotic translation initiation factor 4G by the EV71 2A{sup pro} protein may contribute to the decrease in XBP1s expression. Knockdown of XBP1 increased viral protein expression, and the synthesis of EV71 viral protein and the production of EV71 viral particles were inhibited in XBP1-overexpressing RD cells. When incubated with replication-deficient and UV-irradiated EV71, XBP1-overexpressing RD cells exhibited reduced viral RNA levels, suggesting that the inhibition of XBP1s by viral infection may underlie viral entry, which is required for viral replication. Our findings are the first indication of the ability of XBP1 to inhibit viral entry, possibly via its transcriptional activity in regulating molecules in the endocytic machinery.

  3. Thermophysics Issues Relevant to High-Speed Earth Entry of Large Asteroids (United States)

    Prabhu, D.; Saunders, D.; Agrawal, P.; Allen, G.; Bauschlicher, C.; Brandis, A.; Chen, Y.-K.; Jaffe, R.; Schulz, J.; Stern, E.; hide


    Physics of atmospheric entry of meteoroids was an active area of research at NASA ARC up to the early 1970s (e.g., the oft-cited work of Baldwin and Sheaffer). However, research in the area seems to have ended with the Apollo program, and any ties with an active international meteor physics community seem to have significantly diminished thereafter. In the decades following the 1970s, the focus of entry physics at NASA ARC has been on improvement of the math models of shock-layer physics (especially in chemical kinetics and radiation) and thermal response of ablative materials used for capsule heatshields. With the overarching objectives of understanding energy deposition into the atmosphere and fragmentation, could these modern analysis tools and processes be applied to the problem of atmospheric entry of meteoroids as well? In the presentation we will explore: (i) the physics of atmospheric entries of meteoroids using our current state-of-the-art tools and processes, (ii) how multiple bodies interact, and (iii) the influence of wall blowing on flow dynamics.

  4. Passive Stability on an Entry Vehicle to Enhance Crew Survival (United States)

    Deger, Daniel J.; Hoffman, David; Crull, Tim; Cuthbert, Peter; Liama, Eduardo; Madsen, Chris; Stuart, Phil; Bryant, Lee


    The most desirable crew survival feature for an entry vehicle is probably a full coverage escape system. With full coverage escape, crew survival is maintained for a wide range of failures by the allowing the crew to escape from the failed vehicle and performing the entry to touchdown flight phase in an alternative system. However, there are considerable challenges in providing a separate entry capability, and for some programs, requiring full coverage escape could result in program cancellation. An alternative means of providing for crew survival if the flight control system fails is to design a return vehicle that can enter without active attitude control. A study was performed to assess the feasibility of performing a totally passive entry. Lift over drag has a major impact on performing a passive entry, so a parametric of three typical lift over drag concepts was performed. First an assessment of historical entry vehicles was completed. Second an assessment of end of mission entry trajectories and entry trajectories initiated from ascent abort profiles were made. Trajectories for a wide array of pitch, yaw, and roll rates were made. Third, six-degree-of freedom analyses of the entry were performed. FOP a truly passive return, the entry vehicle must trim in only the heat shield forward orientation. An assessment of the effect of center of gravity placement to achieve this orientation was made.

  5. Structural correlates of rotavirus cell entry.

    Directory of Open Access Journals (Sweden)

    Aliaa H Abdelhakim


    Full Text Available Cell entry by non-enveloped viruses requires translocation into the cytosol of a macromolecular complex--for double-strand RNA viruses, a complete subviral particle. We have used live-cell fluorescence imaging to follow rotavirus entry and penetration into the cytosol of its ∼ 700 Å inner capsid particle ("double-layered particle", DLP. We label with distinct fluorescent tags the DLP and each of the two outer-layer proteins and track the fates of each species as the particles bind and enter BSC-1 cells. Virions attach to their glycolipid receptors in the host cell membrane and rapidly become inaccessible to externally added agents; most particles that release their DLP into the cytosol have done so by ∼ 10 minutes, as detected by rapid diffusional motion of the DLP away from residual outer-layer proteins. Electron microscopy shows images of particles at various stages of engulfment into tightly fitting membrane invaginations, consistent with the interpretation that rotavirus particles drive their own uptake. Electron cryotomography of membrane-bound virions also shows closely wrapped membrane. Combined with high resolution structural information about the viral components, these observations suggest a molecular model for membrane disruption and DLP penetration.

  6. Extraterrestrial Regolith Derived Atmospheric Entry Heat Shields (United States)

    Hogue, Michael D.; Mueller, Robert P.; Sibille, Laurent; Hintze, Paul E.; Rasky, Daniel J.


    High-mass planetary surface access is one of NASAs technical challenges involving entry, descent and landing (EDL). During the entry and descent phase, frictional interaction with the planetary atmosphere causes a heat build-up to occur on the spacecraft, which will rapidly destroy it if a heat shield is not used. However, the heat shield incurs a mass penalty because it must be launched from Earth with the spacecraft, thus consuming a lot of precious propellant. This NASA Innovative Advanced Concept (NIAC) project investigated an approach to provide heat shield protection to spacecraft after launch and prior to each EDL thus potentially realizing significant launch mass savings. Heat shields fabricated in situ can provide a thermal-protection system for spacecraft that routinely enter a planetary atmosphere. By fabricating the heat shield with space resources from materials available on moons and asteroids, it is possible to avoid launching the heat-shield mass from Earth. Regolith has extremely good insulating properties and the silicates it contains can be used in the fabrication and molding of thermal-protection materials. In this paper, we will describe three types of in situ fabrication methods for heat shields and the testing performed to determine feasibility of this approach.

  7. Essays on international market entry : Strategic alliance governance and product segment entry

    NARCIS (Netherlands)

    Eapen, A.


    This dissertation consists of three empirical studies on the entry and evolution of foreign firms in a new market. The common thread through these three essays is a focus on the scope of the foreign firm in a host country, and on how this scope is shaped by local firms and environments. The first

  8. Flow Redistribution Between Legs and Brain During STS 93 Re-Entry and Landing (United States)

    Arbeille, P.; Meck, J.; Porcher, M.; Benavides, E.; Martin, D. S.; South, D. A.; Ribeiro, C.; Westover, A.


    The objective was to quantify bit by bit the arterial hemodynamic response to the successive acceleration induced fluid shifts during re-entry and landing. Method: The astronaut instrumented himself with a flat Doppler probe fixed on the skin, a blood pressure arm cuff, and 3 ECG electrodes. The ICMS (integrated cardiovascular monitoring system, 15x15x25 cu cm, battery powered) designed to monitor Blood pressure, ECG, cerebral and femoral flows was fixed below the astronaut sit in the middeck. Recordings started 5 minutes before de-orbiting (TIG) and stopped 5 min after wheels stop. Results. During re-entry blood pressure increased by 20% at TIG, and then by 25 to 30% during the highest Gz accelerations (approx 1 S g ) . The cerebral flow remained decreased by 10 to 15% below inflight value all during the Entry and landing phases. Conversely the femoral flow increased at TIG and entry ( + l0 to 20%), recovered at 0.lg, and then decreased in proportion with the Gz acceleration (-10% to -40% from 0.5g to 1.5g). The reduction in Femoral flow was associated with an opposite variation in lower limb vascular resistance. Consequently the cerebral flow/femoral flow ratio decreased at TIG and entry (-20%), and then increased according to the Gz acceleration level ( + l0 to +40% from 0.5 to 1.5g). Conclusion: During orthostatic tests (Stand LBNP tests) the cerebral to femoral flow ratio allowed to quantify the efficiency of the flow redistribution between these 2 areas and predicted orthostatic intolerance. In the present case the astronaut was found orthostatically tolerant at postflight tilt tests, but we suggest that during re-entry this parameter could predict the occurrence of syncope in severely disadapted astronauts.

  9. 78 FR 76152 - Agency Information Collection Activities: Transportation Entry and Manifest of Goods Subject to... (United States)


    ... methodology and assumptions used; (3) Enhance the quality, utility, and clarity of the information to be... CFR 10.61, 19 CFR 18.11, 19 CFR 18.20 and 19 CFR 18.25, and can be found at

  10. 75 FR 60772 - Agency Information Collection Activities: Transportation Entry and Manifest of Goods Subject to... (United States)


    ... proposed collection of information, including the validity of the methodology and assumptions used; ( . Current Actions: This submission is being made to extend the expiration...

  11. Titan Imagery with Keck AO during and after Probe Entry

    Energy Technology Data Exchange (ETDEWEB)

    de Pater, I; Adamkovics, M; Bouchez, A H; Brown, M E; Gibbard, S G; Marchis, F; Roe, H G; Schaller, E L; Young, E


    We present adaptive optics data from the 10-m W.M. Keck telescope that were taken during the time the Huygens probe descended through Titan's atmosphere, and on the days following touch-down. The spatial resolution of the images is typically {approx}0.04-inch, or {approx}240 km on Titan (60 km/pixel). No probe entry signal was detected at levels exceeding 0.8 {micro}Jy (3-{sigma}) per pixel (0.01-inch), which although within the range of predicted flux levels, cannot constrain any models. We present data on Titan's surface, troposphere and stratosphere during the days following probe entry, when the solar phase angle varied from 0.05{sup o} up to 0.8{sup o}, with the Sun in the West. Contrary to expectation, the data often showed the East side to be brightest. Adding data obtained with Keck and Gemini over the past few years reveals that the East-West asymmetry can be explained by a combination of the solar phase angle effect together with a general preponderance of haze on Titan's East or morning hemisphere. The troposphere was characterized by quiescent weather; only a few small clouds were present near the south pole, at typical altitudes of 30-40 km. While stratospheric haze was prominent over the northern hemisphere, tropospheric haze dominated the south, from the S. pole up to latitudes of {approx} -45{sup o}. An intriguing observation is that obtained at 1.22 {micro}m, which revealed haze in the form of a collar at -60{sup o}, in contrast to the polar haze cap as usually seen. A comparison of narrow band JHK images of Titan's surface with that obtained by Cassini ISS shows a striking resemblance in small-scale features. After a decent attempt to remove the atmosphere from the images, the surface contrast between dark and bright areas may be larger at 2 {micro}m than at 1.6 and 1.3 {micro}m. If true, this could imply that the dark areas on Titan's surface are covered by a coarser grained frost than the bright areas, and/or that there

  12. Orthopoxvirus species and strain differences in cell entry. (United States)

    Bengali, Zain; Satheshkumar, P S; Moss, Bernard


    Vaccinia virus (VACV) enters cells by a low pH endosomal route or by direct fusion with the plasma membrane. We previously found differences in entry properties of several VACV strains: entry of WR was enhanced by low pH, reduced by bafilomycin A1 and relatively unaffected by heparin, whereas entry of IHD-J, Copenhagen and Elstree were oppositely affected. Since binding and entry modes may have been selected by specific conditions of in vitro propagation, we now examined the properties of three distinct, recently isolated cowpox viruses and a monkeypox virus as well as additional VACV and cowpox virus strains. The recent isolates were more similar to WR than to other VACV strains, underscoring the biological importance of endosomal entry by orthopoxviruses. Sequence comparisons, gene deletions and gene swapping experiments indicated that viral determinants, other than or in addition to the A26 and A25 "fusion-suppressor" proteins, impact entry properties. Published by Elsevier Inc.

  13. Orthopoxvirus species and strain differences in cell entry

    Energy Technology Data Exchange (ETDEWEB)

    Bengali, Zain; Satheshkumar, P.S. [Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3210 (United States); Moss, Bernard, E-mail: [Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3210 (United States)


    Vaccinia virus (VACV) enters cells by a low pH endosomal route or by direct fusion with the plasma membrane. We previously found differences in entry properties of several VACV strains: entry of WR was enhanced by low pH, reduced by bafilomycin A1 and relatively unaffected by heparin, whereas entry of IHD-J, Copenhagen and Elstree were oppositely affected. Since binding and entry modes may have been selected by specific conditions of in vitro propagation, we now examined the properties of three distinct, recently isolated cowpox viruses and a monkeypox virus as well as additional VACV and cowpox virus strains. The recent isolates were more similar to WR than to other VACV strains, underscoring the biological importance of endosomal entry by orthopoxviruses. Sequence comparisons, gene deletions and gene swapping experiments indicated that viral determinants, other than or in addition to the A26 and A25 'fusion-suppressor' proteins, impact entry properties.

  14. Mid-L/D Lifting Body Entry Demise Analysis (United States)

    Ling, Lisa


    The mid-lift-to-drag ratio (mid-L/D) lifting body is a fully autonomous spacecraft under design at NASA for enabling a rapid return of scientific payloads from the International Space Station (ISS). For contingency planning and risk assessment for the Earth-return trajectory, an entry demise analysis was performed to examine three potential failure scenarios: (1) nominal entry interface conditions with loss of control, (2) controlled entry at maximum flight path angle, and (3) controlled entry at minimum flight path angle. The objectives of the analysis were to predict the spacecraft breakup sequence and timeline, determine debris survival, and calculate the debris dispersion footprint. Sensitivity analysis was also performed to determine the effect of the initial pitch rate on the spacecraft stability and breakup during the entry. This report describes the mid-L/D lifting body and presents the results of the entry demise and sensitivity analyses.

  15. Current Research in Bookkeeping/Accounting and Basic Business Subjects (United States)

    Nanassy, Louis C., Comp.


    Listed are 26 doctoral and masters theses completed during the years 1974-5 involving research in bookkeeping/accounting and basic business subjects. The entries are arranged alphabetically by author and include the title of the study and the name of the associated institution. (MS)

  16. Protease inhibitors targeting coronavirus and filovirus entry. (United States)

    Zhou, Yanchen; Vedantham, Punitha; Lu, Kai; Agudelo, Juliet; Carrion, Ricardo; Nunneley, Jerritt W; Barnard, Dale; Pöhlmann, Stefan; McKerrow, James H; Renslo, Adam R; Simmons, Graham


    In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases. The respective enzymes are thus excellent targets for antiviral intervention. In cell culture, activation of Ebola virus, as well as SARS- and MERS-coronavirus can be accomplished by the endosomal cysteine proteases, cathepsin L (CTSL) and cathepsin B (CTSB). In addition, SARS- and MERS-coronavirus can use serine proteases localized at the cell surface, for their activation. However, it is currently unclear which protease(s) facilitate viral spread in the infected host. We report here that the cysteine protease inhibitor K11777, ((2S)-N-[(1E,3S)-1-(benzenesulfonyl)-5-phenylpent-1-en-3-yl]-2-{[(E)-4-methylpiperazine-1-carbonyl]amino}-3-phenylpropanamide) and closely-related vinylsulfones act as broad-spectrum antivirals by targeting cathepsin-mediated cell entry. K11777 is already in advanced stages of development for a number of parasitic diseases, such as Chagas disease, and has proven to be safe and effective in a range of animal models. K11777 inhibition of SARS-CoV and Ebola virus entry was observed in the sub-nanomolar range. In order to assess whether cysteine or serine proteases promote viral spread in the host, we compared the antiviral activity of an optimized K11777-derivative with that of camostat, an inhibitor of TMPRSS2 and related serine proteases. Employing a pathogenic animal model of SARS-CoV infection, we demonstrated that viral spread and pathogenesis of SARS-CoV is driven by serine rather than cysteine proteases and can be effectively prevented by camostat. Camostat has been clinically used to treat chronic pancreatitis, and thus represents an exciting potential therapeutic for respiratory coronavirus infections. Our results indicate that camostat, or similar serine protease inhibitors, might be an effective option for treatment of SARS and

  17. An Automated Evaluation Metric for Chinese Text Entry


    Jiang, Mike Tian-Jian; Zhan, James; Lin, Jaimie; Lin, Jerry; Hsu, Wen-Lien


    In this paper, we propose an automated evaluation metric for text entry. We also consider possible improvements to existing text entry evaluation metrics, such as the minimum string distance error rate, keystrokes per character, cost per correction, and a unified approach proposed by MacKenzie, so they can accommodate the special characteristics of Chinese text. Current methods lack an integrated concern about both typing speed and accuracy for Chinese text entry evaluation. Our goal is to re...

  18. Methodological aspects of journaling a dynamic adjusting entry model

    Directory of Open Access Journals (Sweden)

    Vlasta Kašparovská


    Full Text Available This paper expands the discussion of the importance and function of adjusting entries for loan receivables. Discussion of the cyclical development of adjusting entries, their negative impact on the business cycle and potential solutions has intensified during the financial crisis. These discussions are still ongoing and continue to be relevant to members of the professional public, banking regulators and representatives of international accounting institutions. The objective of this paper is to evaluate a method of journaling dynamic adjusting entries under current accounting law. It also expresses the authors’ opinions on the potential for consistently implementing basic accounting principles in journaling adjusting entries for loan receivables under a dynamic model.

  19. Passive Earth Entry Vehicle Landing Test (United States)

    Kellas, Sotiris


    Two full-scale passive Earth Entry Vehicles (EEV) with realistic structure, surrogate sample container, and surrogate Thermal Protection System (TPS) were built at NASA Langley Research Center (LaRC) and tested at the Utah Test and Training Range (UTTR). The main test objective was to demonstrate structural integrity and investigate possible impact response deviations of the realistic vehicle as compared to rigid penetrometer responses. With the exception of the surrogate TPS and minor structural differences in the back shell construction, the two test vehicles were identical in geometry and both utilized the Integrated Composite Stiffener Structure (ICoSS) structural concept in the forward shell. The ICoSS concept is a lightweight and highly adaptable composite concept developed at NASA LaRC specifically for entry vehicle TPS carrier structures. The instrumented test vehicles were released from a helicopter approximately 400 m above ground. The drop height was selected such that at least 98% of the vehicles terminal velocity would be achieved. While drop tests of spherical penetrometers and a low fidelity aerodynamic EEV model were conducted at UTTR in 1998 and 2000, this was the first time a passive EEV with flight-like structure, surrogate TPS, and sample container was tested at UTTR for the purpose of complete structural system validation. Test results showed that at a landing vertical speed of approximately 30 m/s, the test vehicle maintained structural integrity and enough rigidity to penetrate the sandy clay surface thus attenuating the landing load, as measured at the vehicle CG, to less than 600 g. This measured deceleration was found to be in family with rigid penetrometer test data from the 1998 and 2000 test campaigns. Design implications of vehicle structure/soil interaction with respect to sample container and sample survivability are briefly discussed.

  20. The Hera Saturn entry probe mission (United States)

    Mousis, O.; Atkinson, D. H.; Spilker, T.; Venkatapathy, E.; Poncy, J.; Frampton, R.; Coustenis, A.; Reh, K.; Lebreton, J.-P.; Fletcher, L. N.; Hueso, R.; Amato, M. J.; Colaprete, A.; Ferri, F.; Stam, D.; Wurz, P.; Atreya, S.; Aslam, S.; Banfield, D. J.; Calcutt, S.; Fischer, G.; Holland, A.; Keller, C.; Kessler, E.; Leese, M.; Levacher, P.; Morse, A.; Muñoz, O.; Renard, J.-B.; Sheridan, S.; Schmider, F.-X.; Snik, F.; Waite, J. H.; Bird, M.; Cavalié, T.; Deleuil, M.; Fortney, J.; Gautier, D.; Guillot, T.; Lunine, J. I.; Marty, B.; Nixon, C.; Orton, G. S.; Sánchez-Lavega, A.


    The Hera Saturn entry probe mission is proposed as an M-class mission led by ESA with a contribution from NASA. It consists of one atmospheric probe to be sent into the atmosphere of Saturn, and a Carrier-Relay spacecraft. In this concept, the Hera probe is composed of ESA and NASA elements, and the Carrier-Relay Spacecraft is delivered by ESA. The probe is powered by batteries, and the Carrier-Relay Spacecraft is powered by solar panels and batteries. We anticipate two major subsystems to be supplied by the United States, either by direct procurement by ESA or by contribution from NASA: the solar electric power system (including solar arrays and the power management and distribution system), and the probe entry system (including the thermal protection shield and aeroshell). Hera is designed to perform in situ measurements of the chemical and isotopic compositions as well as the dynamics of Saturn's atmosphere using a single probe, with the goal of improving our understanding of the origin, formation, and evolution of Saturn, the giant planets and their satellite systems, with extrapolation to extrasolar planets. Hera's aim is to probe well into the cloud-forming region of the troposphere, below the region accessible to remote sensing, to the locations where certain cosmogenically abundant species are expected to be well mixed. By leading to an improved understanding of the processes by which giant planets formed, including the composition and properties of the local solar nebula at the time and location of giant planet formation, Hera will extend the legacy of the Galileo and Cassini missions by further addressing the creation, formation, and chemical, dynamical, and thermal evolution of the giant planets, the entire solar system including Earth and the other terrestrial planets, and formation of other planetary systems.

  1. Parvoviral host range and cell entry mechanisms. (United States)

    Cotmore, Susan F; Tattersall, Peter


    Parvoviruses elaborate rugged nonenveloped icosahedral capsids of approximately 260 A in diameter that comprise just 60 copies of a common core structural polypeptide. While serving as exceptionally durable shells, capable of protecting the single-stranded DNA genome from environmental extremes, the capsid also undergoes sequential conformational changes that allow it to translocate the genome from its initial host cell nucleus all the way into the nucleus of its subsequent host. Lacking a duplex transcription template, the virus must then wait for its host to enter S-phase before it can initiate transcription and usurp the cell's synthetic pathways. Here we review cell entry mechanisms used by parvoviruses. We explore two apparently distinct modes of host cell specificity, first that used by Minute virus of mice, where subtle glycan-specific interactions between host receptors and residues surrounding twofold symmetry axes on the virion surface mediate differentiated cell type target specificity, while the second involves novel protein interactions with the canine transferrin receptor that allow a mutant of the feline leukopenia serotype, Canine parvovirus, to bind to and infect dog cells. We then discuss conformational shifts in the virion that accompany cell entry, causing exposure of a capsid-tethered phospholipase A2 enzymatic core that acts as an endosomolytic agent to mediate virion translocation across the lipid bilayer into the cell cytoplasm. Finally, we discuss virion delivery into the nucleus, and consider the nature of transcriptionally silent DNA species that, escaping detection by the cell, might allow unhampered progress into S-phase and hence unleash the parvoviral Trojan horse.

  2. Disabled graduate-entry medical student experience. (United States)

    Tso, Simon


    This study explored the experiences of graduate-entry medicine degree programme students who were disabled on the disclosure of their disability and the challenging disability issues they encountered during their degree programme. Eight student volunteers with a disability from the University of Warwick graduate-entry medicine degree programme took part in this study. Audio recordings of their semi-structured interviews were transcribed verbatim and analysed thematically. Contributory factors to a reluctance or delay in disclosing disability to the medical school included confidentiality concerns, the potential impact of disclosure on their medical school application outcome and not perceiving their disability had an impact on their ability to function. They disclosed their disability for a range of professional and practical considerations. One participant was investigated and diagnosed with dyslexia following failure in a medical school examination. Disabled medical students encountered challenging issues such as having concerns about their future fitness to practice and employability, repeated disclosure of disability, confidentiality, abuse and difficulties in organising reasonable adjustments. Disabled medical students encounter challenging issues DISCUSSION: Medical school staff should keep an open mind about undiagnosed disability as a potential contributory factor to graduate students' academic underperformance. Participants expressed concerns about the management of their disability information that could potentially be addressed through regular dialogue between the students with a disability and medical school representatives, to define who, when and how other staff members could have access to the students' disability information. Despite the challenges students with a disability encountered during their degree programme, they viewed themselves as individuals who were in a good position to empathise with patients and understand their needs. © 2017 John

  3. Quality of data entry using single entry, double entry and automated forms processing--an example based on a study of patient-reported outcomes.

    Directory of Open Access Journals (Sweden)

    Aksel Paulsen

    Full Text Available BACKGROUND: The clinical and scientific usage of patient-reported outcome measures is increasing in the health services. Often paper forms are used. Manual double entry of data is defined as the definitive gold standard for transferring data to an electronic format, but the process is laborious. Automated forms processing may be an alternative, but further validation is warranted. METHODS: 200 patients were randomly selected from a cohort of 5777 patients who had previously answered two different questionnaires. The questionnaires were scanned using an automated forms processing technique, as well as processed by single and double manual data entry, using the EpiData Entry data entry program. The main outcome measure was the proportion of correctly entered numbers at question, form and study level. RESULTS: Manual double-key data entry (error proportion per 1000 fields = 0.046 (95% CI: 0.001-0.258 performed better than single-key data entry (error proportion per 1000 fields = 0.370 (95% CI: 0.160-0.729, (p = 0.020. There was no statistical difference between Optical Mark Recognition (error proportion per 1000 fields = 0.046 (95% CI: 0.001-0.258 and double-key data entry (p = 1.000. With the Intelligent Character Recognition method, there was no statistical difference compared to single-key data entry (error proportion per 1000 fields = 6.734 (95% CI: 0.817-24.113, (p = 0.656, as well as double-key data entry (error proportion per 1000 fields = 3.367 (95% CI: 0.085-18.616, (p = 0.319. CONCLUSIONS: Automated forms processing is a valid alternative to double manual data entry for highly structured forms containing only check boxes, numerical codes and no dates. Automated forms processing can be superior to single manual data entry through a data entry program, depending on the method chosen.

  4. The Bulgarian Odonata database – current status, organisation and a case study new entries

    Directory of Open Access Journals (Sweden)

    Yordan Kutsarov


    Full Text Available Bulgarian Odonata database is analysed for the period of the last 10 years. All new entries are summarised in individual species graphs representing the trends in data compilations. Special attention is paid on the role of communities in this process with a single study case which is evident of how a small contribution could elucidate important new information on some underexplored areas. It is concluded that for the past 10 years mountain areas and large Bulgarian rivers have been understudied. These should be the priority target areas in the investigations undertaken in near future.

  5. Simulation-Based Analysis of Reentry Dynamics for the Sharp Atmospheric Entry Vehicle (United States)

    Tillier, Clemens Emmanuel


    This thesis describes the analysis of the reentry dynamics of a high-performance lifting atmospheric entry vehicle through numerical simulation tools. The vehicle, named SHARP, is currently being developed by the Thermal Protection Materials and Systems branch of NASA Ames Research Center, Moffett Field, California. The goal of this project is to provide insight into trajectory tradeoffs and vehicle dynamics using simulation tools that are powerful, flexible, user-friendly and inexpensive. Implemented Using MATLAB and SIMULINK, these tools are developed with an eye towards further use in the conceptual design of the SHARP vehicle's trajectory and flight control systems. A trajectory simulator is used to quantify the entry capabilities of the vehicle subject to various operational constraints. Using an aerodynamic database computed by NASA and a model of the earth, the simulator generates the vehicle trajectory in three-dimensional space based on aerodynamic angle inputs. Requirements for entry along the SHARP aerothermal performance constraint are evaluated for different control strategies. Effect of vehicle mass on entry parameters is investigated, and the cross range capability of the vehicle is evaluated. Trajectory results are presented and interpreted. A six degree of freedom simulator builds on the trajectory simulator and provides attitude simulation for future entry controls development. A Newtonian aerodynamic model including control surfaces and a mass model are developed. A visualization tool for interpreting simulation results is described. Control surfaces are roughly sized. A simple controller is developed to fly the vehicle along its aerothermal performance constraint using aerodynamic flaps for control. This end-to-end demonstration proves the suitability of the 6-DOF simulator for future flight control system development. Finally, issues surrounding real-time simulation with hardware in the loop are discussed.

  6. An Examination of Market Entry Perspectives in Emerging Markets

    Directory of Open Access Journals (Sweden)

    Marvin O. Bates


    Full Text Available Purpose – The purpose of this article is to describe the marketing-oriented market entry approaches that businesses are currently using across the three levels of the world economic pyramid (i.e., WEP. These levels are the Top-tier, the Middle-tier, and the Base of the Pyramid-tier (i.e., BoP-tier. Methodology – The literature of the BoP was reviewed, and market entry approaches were itemized across the three WEP levels. Secondly, BoP strategic theorists including Prahalad identified the need for a BoP marketing focus replacing the traditional 4Ps marketing approach (i.e., Product, Price, Place and Promotion with the BoP-specific 4As marketing approach (i.e., Awareness, Affordability, Access and Availability. This 4As marketing approach is discussed. Findings – New marketing-oriented market-entry approaches are proposed for each of the three WEP levels. These approaches are based on where in the WEP the firm currently exists, and where in the WEP the firm desires to refocus market-entry activities; identified approaches include: inter-country expansion, intra-country entry, adjacent market entry, and extended market entry. Secondly, the absence of a clearly articulated marketing strategy for middle-tier markets was observed. Practical implications – This article has two specific applications. First, it summarizes the evolving market entry perspectives to provide a context for future market research in both emerging markets and the pre-emerging BoP markets. Second, the future requirement for an articulated marketing strategy for middle-tier markets is suggested. Originality – This article examined existing market entry approaches across all three levels of the WEP, inclusive of the BoP economic level. The language used to clarify market entry movements was extended, providing a specificity of description not previously found in either the existing market entry or BoP literature.

  7. Seismic Parameters of Mining-Induced Aftershock Sequences for Re-entry Protocol Development (United States)

    Vallejos, Javier A.; Estay, Rodrigo A.


    A common characteristic of deep mines in hard rock is induced seismicity. This results from stress changes and rock failure around mining excavations. Following large seismic events, there is an increase in the levels of seismicity, which gradually decay with time. Restricting access to areas of a mine for enough time to allow this decay of seismic events is the main approach in re-entry strategies. The statistical properties of aftershock sequences can be studied with three scaling relations: (1) Gutenberg-Richter frequency magnitude, (2) the modified Omori's law (MOL) for the temporal decay, and (3) Båth's law for the magnitude of the largest aftershock. In this paper, these three scaling relations, in addition to the stochastic Reasenberg-Jones model are applied to study the characteristic parameters of 11 large magnitude mining-induced aftershock sequences in four mines in Ontario, Canada. To provide guidelines for re-entry protocol development, the dependence of the scaling relation parameters on the magnitude of the main event are studied. Some relations between the parameters and the magnitude of the main event are found. Using these relationships and the scaling relations, a space-time-magnitude re-entry protocol is developed. These findings provide a first approximation to concise and well-justified guidelines for re-entry protocol development applicable to the range of mining conditions found in Ontario, Canada.

  8. Characteristics of the overflow pollution of storm drains with inappropriate sewage entry. (United States)

    Yin, Hailong; Lu, Yi; Xu, Zuxin; Li, Huaizheng; Schwegler, Benedict R


    To probe the overflow pollution of separate storm drains with inappropriate sewage entries, in terms of the relationship between sewage entries and the corresponding dry-weather and wet-weather overflow, the monitoring activities were conducted in a storm drainage system in the Shanghai downtown area (374 ha). In this study site, samples from inappropriately entered dry-weather sewage and the overflow due to storm pumps operation on dry-weather and wet-weather days were collected and then monitored for six water quality constituents. It was found that overflow concentrations of dry-weather period could be higher than those of wet-weather period; under wet-weather period, the overflow concentrations of storm drains were close to or even higher than that of combined sewers. Relatively strong first flush mostly occurred under heavy rain that satisfied critical rainfall amount, maximum rainfall intensity, and maximum pumping discharge, while almost no first flush effect or only weak first flush effect was found for the other rainfall events. Such phenomenon was attributed to lower in-line pipe storage as compared to that of the combined sewers, and serious sediment accumulation within the storm pipes due to sewage entry. For this kind of system, treating a continuous overflow rate is a better strategy than treating the maximum amount of early part of the overflow. Correcting the key inappropriate sewage entries into storm drains should also be focused.

  9. Study on Mini Re-Entry System Using Deployable Membrane Aeroshell (United States)

    Koyama, Masashi; Suzuki, Kojiro; Imamura, Osamu; Yamada, Kazuhiko

    An aeroshell made from membrane material have an advantage of reduction in the aerodynamic heating, because its small mass and large area enable us to make the low-ballistic-coefficient flight, in which the vehicle decelerates at very high altitude with low atmospheric density. In this paper, we propose a new concept of mini re-entry system for small satellites. This vehicle is called "FEATHER" (Flexible Expanded Aeroshell with Tiny payload Harness for Entry and Recovery). "FEATHER" is a novel re-entry and recovery system, featuring the autonomous aeroshell deployment, the low-ballistic-coefficient re-entry with less severe aerodynamicc heating and so on. FEATHER is composed of the membrane aeroshell made from the high-temperature cloth called ZYLON®, an outer frame made of Shape Memory Alloy (SMA) and a payload. When the aeroshell receives the aerodynamic heating, the temperature of SMA frame rises and restores the circular shape as memorized beforehand. Then the membrane aeroshell is automatically deployed. Therefore the vehicle can achieve the low-ballistic-coefficient flight with a drastic reduction in the aerodynamic heating without any additional sensors, controllers and actuators. The preliminary studies made on FEATHER system so far including the hypersonic wind tunnel experiments are presented in this paper.



    Kaplan, Tugba


    Firms, whichhave to compete with global firms in domestic market, try to internationalizefor gaining competitive advantage. The aim of this study is to recommend a conceptual framework to explain thedynamics of internationalization process of leader and follower firms thatinternationalize from an emerging country. In this study, author tries tofigure out the determinants of entrymode decisions of follower firms. In addition, bandwagon effect of leaders'entry mode strategies on followers&...

  11. Local perinuclear calcium signals associated with mitosis-entry in early sea urchin embryos



    Using calcium-sensitive dyes together with their dextran conjugates and confocal microscopy, we have looked for evidence of localized calcium signaling in the region of the nucleus before entry into mitosis, using the sea urchin egg first mitotic cell cycle as a model. Global calcium transients that appear to originate from the nuclear area are often observed just before nuclear envelope breakdown (NEB). In the absence of global increases in calcium, confocal microscopy using Calcium Green- 1...

  12. Praxis, subjectivity and sense

    Directory of Open Access Journals (Sweden)

    Alfredo Gómez-Muller


    Full Text Available A primordial aspect of the Sartrian critique of alienation concerns understanding the analytic ideology as the domination of materiality over the symbolic, in other words as the reification of the human, and therefore as anticulture. In the context of contemporary nihilism, the decoding of the mechanisms which consign praxis to the practico-inert requires a critique of the relations between the social sciences and philosophy, which in its turn implies a new theory of the relation between what Sartre calls the "notion" (the area of subjectivity and the "concept" (objectivity, From this perspective, the deconstruction of the established frontiers between the social sciences and philosophy, and between the conceptual and the narrative, is corelative to a redefinition of the relation between theory and practice.

  13. Racial/Ethnic Disparities in ADHD Diagnosis by Kindergarten Entry (United States)

    Morgan, Paul L.; Hillemeier, Marianne M.; Farkas, George; Maczuga, Steve


    Background: Whether and to what extent racial/ethnic disparities in attention-deficit/hyperactivity disorder (ADHD) diagnosis occur by kindergarten entry is currently unknown. We investigated risk factors associated with an ADHD diagnosis by kindergarten entry generally, and specifically whether racial/ethnic disparities in ADHD diagnosis occur by…

  14. 19 CFR 147.44 - Entry for another fair. (United States)


    ... TREASURY (CONTINUED) TRADE FAIRS Disposition of Articles Entered for Fairs § 147.44 Entry for another fair. Articles entered for a fair which are to be entered for another fair under the provisions of this part... 19 Customs Duties 2 2010-04-01 2010-04-01 false Entry for another fair. 147.44 Section 147.44...

  15. Entry, Pricing, and Product Design in an Initially Monopolized Market (United States)

    Davis, Steven J.; Murphy, Kevin M.; Topel, Robert H.


    We analyze entry, pricing, and product design in a model with differentiated products. Market equilibrium can be "separating," with multiple sellers and a sorting of heterogeneous consumers across goods, or "exclusionary," with one seller serving all customer types. Entry into an initially monopolized market can occur because of cost reductions or…

  16. 19 CFR 146.63 - Entry for consumption. (United States)


    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Entry for consumption. 146.63 Section 146.63... TREASURY (CONTINUED) FOREIGN TRADE ZONES Transfer of Merchandise From a Zone § 146.63 Entry for consumption... status may be entered for consumption from a zone. (b) Zone-restricted merchandise. Merchandise in a zone...

  17. Strategic advantage and the optimal exercise of entry options

    NARCIS (Netherlands)

    Perotti, E.C.; Rossetto, S.


    We investigate the timing and the valuation of strategic investment aimed at enhancing entry opportunities in related market segments. As demand is uncertain, entry options should be exercised at the optimal time, trading off the market share gain against the option to wait until more information is

  18. Entry ramps in the Nagel-Schreckenberg model

    DEFF Research Database (Denmark)

    Pedersen, Morten Monrad; Ruhoff, Peder Thusgaard


    This paper describes a way of including entry ramps in the Nagel-Schreckenberg traffic model. The idea is to place what are called shadow cars on a highway next to cars on entry ramps, which enables the drivers to take ramp cars into account. The model is shown to capture important real...

  19. 27 CFR 20.27 - Right of entry and examination. (United States)


    ... Administrative Provisions Authorities § 20.27 Right of entry and examination. An appropriate TTB officer may... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Right of entry and... spirits, denatured alcohol, specially denatured rum or articles (including any substance for use in the...

  20. Cadaveric study for ideal dorsal pedicle screw entry point

    Directory of Open Access Journals (Sweden)

    Sandeep Sonone


    Conclusion: We conclude that the ideal pedicle entry point described here should be considered by surgeons during thoracic pedicle screw instrumentation. The notch at the base of the superior articular process will always remain constant and therefore an important anatomical landmark in guiding the screw toward the entry of the pedicle.

  1. 15 CFR 2011.204 - Entry of specialty sugars. (United States)


    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Entry of specialty sugars. 2011.204... UNITED STATES TRADE REPRESENTATIVE ALLOCATION OF TARIFF-RATE QUOTA ON IMPORTED SUGARS, SYRUPS AND MOLASSES Specialty Sugar § 2011.204 Entry of specialty sugars. An importer or the importer's agent must...

  2. 18 CFR 33.5 - Proposed accounting entries. (United States)


    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Proposed accounting... § 33.5 Proposed accounting entries. If the applicant is required to maintain its books of account in... present proposed accounting entries showing the effect of the transaction with sufficient detail to...

  3. 19 CFR 10.1 - Domestic products; requirements on entry. (United States)


    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Domestic products; requirements on entry. 10.1 Section 10.1 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Articles Exported and Returned § 10.1 Domestic products; requirements on entry. (a) Except as otherwise...

  4. 7 CFR 1205.525 - Entry of gin code number. (United States)


    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Entry of gin code number. 1205.525 Section 1205.525... Cotton Board Rules and Regulations Warehouse Receipts § 1205.525 Entry of gin code number. The warehouse that first receives a bale for storage after ginning shall enter the gin code number of the gin at...

  5. The Language Functioning of Youth at Entry to Residential Treatment (United States)

    Trout, Alexandra L.; Huscroft-D'Angelo, Jacqueline; DeSalvo, Catherine; Gehringer, Robert


    Although much is known about the behavioral and educational characteristics of youth at entry to residential care, little is known about youth language performance. Given the impact of language deficits on outcomes, this study assessed the specific language skills of 70 adolescents at entry to a residential treatment setting. Results revealed…

  6. 27 CFR 478.23 - Right of entry and examination. (United States)


    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Right of entry and... Administrative and Miscellaneous Provisions § 478.23 Right of entry and examination. (a) Except as provided in... of a criminal investigation of a person or persons other than the licensee, (2) For insuring...

  7. Foreign Bank Entry and Credit Allocation in Emerging Markets

    NARCIS (Netherlands)

    Degryse, H.A.; Havrylchyk, O.; Jurzyk, E.; Kozak, S.


    We employ a unique data set containing bank-specific information to explore how foreign bank entry determines credit allocation in emerging markets. We investigate the impact of the mode of foreign entry (greenfield or takeover) on banks’ portfolio allocation to borrowers with different degrees of

  8. 19 CFR 142.3 - Entry documentation required. (United States)


    ... § 141.61(a)(1) of this chapter. (2) Evidence of the right to make entry. Evidence of the right to make entry, as set forth in § 141.11 of this chapter. (3) Commercial invoice. A commercial invoice, except that in those instances listed in § 141.83(d) of this chapter where a commercial invoice is not...

  9. Demographic and academic-related differences between standard-entry and graduate-entry nursing students: a prospective correlational survey. (United States)

    Everett, Bronwyn; Salamonson, Yenna; Trajkovski, Suza; Fernandez, Ritin


    Students who enroll in graduate-entry nursing programs are described as more highly motivated, scoring higher in most learning strategies, and achieving greater academic success than standard-entry nursing students. A prospective correlational design was used to compare the demographic and academic-related characteristics of standard-entry and graduate-entry nursing students in their first year of study. Between 2007 and 2011, students enrolled in the Bachelor of Nursing, Standard Entry and the Bachelor Nursing, Graduate Entry at a large Australian university were surveyed in the first year of their program. Data included English-language usage and time spent in paid work, as well as four dimensions of Pintrich's Motivated Strategies for Learning Questionnaire. Survey data was linked to students' academic grades at the end of the semester. A total of 730 students completed the survey and consented to collection of their academic grades. Graduate-entry students were more likely to be older (28.6 vs. 24.3 years, P groups for use of Extrinsic Goal Orientation as a learning strategy, the graduate-entry students were more likely to identify Peer Learning, Help Seeking and Critical Thinking as strategies for learning than the standard-entry students (P group of students achieved a higher mean GPA (4.8 vs. 4.0, P groups, lower levels of English-language proficiency and increased time spent in paid work were predictors of poorer academic performance. Similar to US-based studies, demographic and academic-related differences were identified between standard-entry and graduate-entry nursing students. However, the study also highlights lower levels of English-language proficiency and increased time spent in paid work negatively impacted academic performance in both groups of nursing students. Copyright © 2013 Elsevier Ltd. All rights reserved.

  10. Determination of entry site for acute type A aortic dissection by initial enhanced CT-scan

    Energy Technology Data Exchange (ETDEWEB)

    Mase, Takenori; Narumiya, Chihiro; Aoyama, Takahiko; Nagata, Yoshihisa [Aichi Medical Univ., Nagakute (Japan). School of Medicine


    Acute type A aortic dissection presents a surgical emergency because conservative therapy is not effective in the majority of instances. Enhanced CT-scan of the chest is commonly available and is considered to be an optimal diagnostic method for this disease. The operative strategy is to resect the primary tear to close the entry site of the aortic dissection and replace it with a tubular Dacron graft. Therefore, the existence of the entry site is important in determining the operative procedure. Based on the numerical value of the enhanced CT-scan inspection, the present study seeks to preoperatively identify the location of the presumed entry site in aortic dissection. From May 1996 to June 1999, 21 consecutive patients (Marfan's syndrome excluded) with acute type A aortic dissection underwent surgical treatment. Nineteen patients were preoperatively examined by enhanced CT-scan: 11 men and 8 women, with a mean age of 61 years. CT-scan slices used for early diagnosis were of the ascending aorta, aortic arch, descending aorta, and thoracoabdominal aorta. The largest diameters of the whole and true lumen were measured from cross-sectional aortic images with a personal computer, and the areas of the whole and true lumen were obtained by the manual tracing method. The true ratio was calculated for the largest diameter and area of the whole lumen. The nineteen patients were divided into two groups according to the location of the entry site based on the operating views. Seven patients with the entry site in the ascending aorta were classified as group A, and twelve patients with the entry site further in the aortic arch and descending aorta were classified as group B. Comparisons were performed by non-parametric analysis. Moreover, a discriminant analysis was applied to evaluate the classification between the two groups. The ratio of the largest diameter of the true lumen in group A at the level of the ascending and descending aorta was significantly greater than

  11. Attitudes towards statistics of graduate entry medical students: the role of prior learning experiences. (United States)

    Hannigan, Ailish; Hegarty, Avril C; McGrath, Deirdre


    While statistics is increasingly taught as part of the medical curriculum, it can be an unpopular subject and feedback from students indicates that some find it more difficult than other subjects. Understanding attitudes towards statistics on entry to graduate entry medical programmes is particularly important, given that many students may have been exposed to quantitative courses in their previous degree and hence bring preconceptions of their ability and interest to their medical education programme. The aim of this study therefore is to explore, for the first time, attitudes towards statistics of graduate entry medical students from a variety of backgrounds and focus on understanding the role of prior learning experiences. 121 first year graduate entry medical students completed the Survey of Attitudes toward Statistics instrument together with information on demographics and prior learning experiences. Students tended to appreciate the relevance of statistics in their professional life and be prepared to put effort into learning statistics. They had neutral to positive attitudes about their interest in statistics and their intellectual knowledge and skills when applied to it. Their feelings towards statistics were slightly less positive e.g. feelings of insecurity, stress, fear and frustration and they tended to view statistics as difficult. Even though 85% of students had taken a quantitative course in the past, only 24% of students described it as likely that they would take any course in statistics if the choice was theirs. How well students felt they had performed in mathematics in the past was a strong predictor of many of the components of attitudes. The teaching of statistics to medical students should start with addressing the association between students' past experiences in mathematics and their attitudes towards statistics and encouraging students to recognise the difference between the two disciplines. Addressing these issues may reduce students

  12. Sensibility and Subjectivity: Levinas’ Traumatic Subject

    Directory of Open Access Journals (Sweden)

    Rashmika Pandya


    Full Text Available The importance of Levinas’ notions of sensibility and subjectivity are evident in the revision of phenomenological method by current phenomenologists such as Jean-Luc Marion and Michel Henry. The criticisms of key tenants of classical phenomenology, intentionality and reduction, are of a particular note. However, there are problems with Levinas’ characterization of subjectivity as essentially sensible. In “Totality and Infinity” and “Otherwise than Being”, Levinas criticizes and recasts a traditional notion of subjectivity, particularly the notion of the subject as the first and foremost rational subject. The subject in Levinas’ works is characterized more by its sensibility and affectedness than by its capacity to reason or affect its world. Levinas ties rationality to economy and suggests an alternative notion of reason that leads to his analysis of the ethical relation as the face-to-face encounter. The ‘origin’ of the social relation is located not in our capacity to know but rather in a sensibility that is diametrically opposed to the reason understood as economy. I argue that the opposition in Levinas’ thought between reason and sensibility is problematic and essentially leads to a self-conflicted subject. In fact, it would seem that violence characterizes the subject’s self-relation and, thus, is also inscribed at the base of the social relation. Rather than overcoming a problematic tendency to dualistic thought in philosophy Levinas merely reverses traditional hierarchies of reason/emotion, subject/object and self/other. 

  13. Comparison of single-entry and double-entry two-step couple screening for cystic fibrosis carriers

    NARCIS (Netherlands)

    tenKate, LP; Verheij, JBGM; Wildhagen, MF; Hilderink, HBM; Kooij, L; Verzijl, JG; Habbema, JDF


    Both single-entry two-step (SETS) couple screening and double-entry two-step (DETS) couple screening have been recommended as methods to screen for cystic fibrosis gene carriers. In this paper we compare the expected results from both types of screening. In general, DETS results in a higher

  14. The Societal Nature of Subjectivity

    DEFF Research Database (Denmark)

    Olesen, Henning Salling


    The HSR Focus presents a psycho-societal approach to qualitative empirical research in several areas of everyday social life. It is an approach which integrates a theory of subjectivity and an interpretation methodology which integrates hermeneutic experiences from text analysis and psychoanalysis...

  15. Optimization of a Hot Structure Aeroshell and Nose Cap for Mars Atmospheric Entry (United States)

    Langston, Sarah L.; Lang, Christapher G.; Samareh, Jamshid A.; Daryabeigi, Kamran


    The National Aeronautics and Space Administration (NASA) is preparing to send humans beyond Low Earth Orbit and eventually to the surface of Mars. As part of the Evolvable Mars Campaign, different vehicle configurations are being designed and considered for delivering large payloads to the surface of Mars. Weight and packing volume are driving factors in the vehicle design, and the thermal protection system (TPS) for planetary entry is a technology area which can offer potential weight and volume savings. The feasibility and potential benefits of a ceramic matrix composite hot structure concept for different vehicle configurations are explored in this paper, including the nose cap for a Hypersonic Inflatable Aerodynamic Decelerator (HIAD) and an aeroshell for a mid lift-to-drag (Mid L/D) concept. The TPS of a planetary entry vehicle is a critical component required to survive the severe aerodynamic heating environment during atmospheric en- try. The current state-of-the-art is an ablative material to protect the vehicle from the heat load. The ablator is bonded to an underlying structure, which carries the mechanical loads associated with entry. The alternative hot structure design utilizes an advanced carbon-carbon material system on the outer surface of the vehicle, which is exposed to the severe heating and acts as a load carrying structure. The preliminary design using the hot structure concept and the ablative concept is determined for the spherical nose cap of the HIAD entry vehicle and the aeroshell of the Mid L/D entry vehicle. The results of the study indicate that the use of hot structures for both vehicle concepts leads to a feasible design with potential weight and volume savings benefits over current state-of-the-art TPS technology that could enable future missions.

  16. Induced charge effects on electrokinetic entry flow (United States)

    Prabhakaran, Rama Aravind; Zhou, Yilong; Zhao, Cunlu; Hu, Guoqing; Song, Yongxin; Wang, Junsheng; Yang, Chun; Xuan, Xiangchun


    Electrokinetic flow, due to a nearly plug-like velocity profile, is the preferred mode for transport of fluids (by electroosmosis) and species (by electrophoresis if charged) in microfluidic devices. Thus far there have been numerous studies on electrokinetic flow within a variety of microchannel structures. However, the fluid and species behaviors at the interface of the inlet reservoir (i.e., the well that supplies the fluid and species) and microchannel are still largely unexplored. This work presents a fundamental investigation of the induced charge effects on electrokinetic entry flow due to the polarization of dielectric corners at the inlet reservoir-microchannel junction. We use small tracing particles suspended in a low ionic concentration fluid to visualize the electrokinetic flow pattern in the absence of Joule heating effects. Particles are found to get trapped and concentrated inside a pair of counter-rotating fluid circulations near the corners of the channel entrance. We also develop a depth-averaged numerical model to understand the induced charge on the corner surfaces and simulate the resultant induced charge electroosmosis (ICEO) in the horizontal plane of the microchannel. The particle streaklines predicted from this model are compared with the experimental images of tracing particles, which shows a significantly better agreement than those from a regular two-dimensional model. This study indicates the strong influences of the top/bottom walls on ICEO in shallow microchannels, which have been neglected in previous two-dimensional models.

  17. Molecular and Cellular Aspects of Rhabdovirus Entry

    Directory of Open Access Journals (Sweden)

    Yves Gaudin


    Full Text Available Rhabdoviruses enter the cell via the endocytic pathway and subsequently fuse with a cellular membrane within the acidic environment of the endosome. Both receptor recognition and membrane fusion are mediated by a single transmembrane viral glycoprotein (G. Fusion is triggered via a low-pH induced structural rearrangement. G is an atypical fusion protein as there is a pH-dependent equilibrium between its pre- and post-fusion conformations. The elucidation of the atomic structures of these two conformations for the vesicular stomatitis virus (VSV G has revealed that it is different from the previously characterized class I and class II fusion proteins. In this review, the pre- and post-fusion VSV G structures are presented in detail demonstrating that G combines the features of the class I and class II fusion proteins. In addition to these similarities, these G structures also reveal some particularities that expand our understanding of the working of fusion machineries. Combined with data from recent studies that revealed the cellular aspects of the initial stages of rhabdovirus infection, all these data give an integrated view of the entry pathway of rhabdoviruses into their host cell.

  18. Intracellular Route of Canine Parvovirus Entry (United States)

    Vihinen-Ranta, Maija; Kalela, Anne; Mäkinen, Päivi; Kakkola, Laura; Marjomäki, Varpu; Vuento, Matti


    The present study was designed to investigate the endocytic pathway involved in canine parvovirus (CPV) infection. Reduced temperature (18°C) or the microtubule-depolymerizing drug nocodazole was found to inhibit productive infection of canine A72 cells by CPV and caused CPV to be retained in cytoplasmic vesicles as indicated by immunofluorescence microscopy. Consistent with previously published results, these data indicate that CPV enters a host cell via an endocytic route and further suggest that microtubule-dependent delivery of CPV to late endosomes is required for productive infection. Cytoplasmic microinjection of CPV particles was used to circumvent the endocytosis and membrane fusion steps in the entry process. Microinjection experiments showed that CPV particles which were injected directly into the cytoplasm, thus avoiding the endocytic pathway, were unable to initiate progeny virus production. CPV treated at pH 5.0 prior to microinjection was unable to initiate virus production, showing that factors of the endocytic route other than low pH are necessary for the initiation of infection by CPV. PMID:9420290

  19. Swiss Army Pathogen: The Salmonella Entry Toolkit

    Directory of Open Access Journals (Sweden)

    Peter J. Hume


    Full Text Available Salmonella causes disease in humans and animals ranging from mild self-limiting gastroenteritis to potentially life-threatening typhoid fever. Salmonellosis remains a considerable cause of morbidity and mortality globally, and hence imposes a huge socio-economic burden worldwide. A key property of all pathogenic Salmonella strains is the ability to invade non-phagocytic host cells. The major determinant of this invasiveness is a Type 3 Secretion System (T3SS, a molecular syringe that injects virulence effector proteins directly into target host cells. These effectors cooperatively manipulate multiple host cell signaling pathways to drive pathogen internalization. Salmonella does not only rely on these injected effectors, but also uses several other T3SS-independent mechanisms to gain entry into host cells. This review summarizes our current understanding of the methods used by Salmonella for cell invasion, with a focus on the host signaling networks that must be coordinately exploited for the pathogen to achieve its goal.

  20. Influence of clay and silica on permeability and capillary entry pressure of chalk reservoirs in the North Sea

    DEFF Research Database (Denmark)

    Røgen, Birte; Fabricius, Ida Lykke


    The permeability and capillary entry pressure of chalk reservoirs are controlled by their porosity and specific surface area. Measured permeabilities are in the range 0.025-5.3 mD and are successfully predicted by use of the Kozeny equation. In this paper we focus on the factors that control spec...

  1. Angle of Attack Modulation for Mars Entry Terminal State Optimization (United States)

    Lafleur, Jarret M.; Cerimele, Christopher J.


    From the perspective of atmospheric entry, descent, and landing (EDL), one of the most foreboding destinations in the solar system is Mars due in part to its exceedingly thin atmosphere. To benchmark best possible scenarios for evaluation of potential Mars EDL system designs, a study is conducted to optimize the entry-to-terminal-state portion of EDL for a variety of entry velocities and vehicle masses, focusing on the identification of potential benefits of enabling angle of attack modulation. The terminal state is envisioned as one appropriate for the initiation of terminal descent via parachute or other means. A particle swarm optimizer varies entry flight path angle, ten bank profile points, and ten angle of attack profile points to find maximum-final-altitude trajectories for a 10 30 m ellipsled at 180 different combinations of values for entry mass, entry velocity, terminal Mach number, and minimum allowable altitude. Parametric plots of maximum achievable altitude are shown, as are examples of optimized trajectories. It is shown that appreciable terminal state altitude gains (2.5-4.0 km) over pure bank angle control may be possible if angle of attack modulation is enabled for Mars entry vehicles. Gains of this magnitude could prove to be enabling for missions requiring high-altitude landing sites. Conclusions are also drawn regarding trends in the bank and angle of attack profiles that produce the optimal trajectories in this study, and directions for future work are identified.

  2. The effects of foreign banks entry in emerging market economies

    Directory of Open Access Journals (Sweden)

    MSc. Florida Veljanoska


    Full Text Available This paper investigates the effects of foreign bank entry in emerging markets. We developed a picture of a multinational bank in an emerging markets by combining statistics from several sources, in order to explore broad range of effects that brings foreign bank entry in the developing countries. Some impacts of foreign bank entry have been thoroughly studied, while others are hardly mention. Entry of foreign bank brings large benefits to host country’s financial system and economies at large. This paper is studying those benefits very carefully, by analyzing the impact of foreign bank entry on economy, government, monetary policy, large enterprises, small and medium size enterprises, domestic bank etc. But, we also consider the fact that at the same time, foreign investment in the financial sector, rises some concerns, and therefore we analyze the negative effects as well. At the end we must admit that although there are some negative consequences from foreign bank entry in emerging markets, the benefits that arise from foreign banks penetration are much more, and this trend of foreign bank entry has brought new positive economic impulse in developing world.

  3. Considering the Language of Computerized Order Entry Systems. (United States)

    Diemert, Simon; Weber, Jens; Price, Morgan


    Computerized Provider Order Entry (CPOE) systems have been shown to introduce new problems into clinical environments. Given the communication intensive nature of these systems considering the language(s) of communication can provide insight into their function and subsequent problems. The current (as November 2015) CPOE literature was reviewed using the language concepts of syntax, semantics, and pragmatics as a lens. In total, 202 articles were considered, of these only 46 received a full review. 145 results related to language concepts were extracted from these articles. These were categorized into five categories: syntax, semantics, system-pragmatics, syntax-pragmatics, and semantic-pragmatics. In total key themes were synthesized. The themes identified can be used to direct further research in the area of CPOE systems. It was found that current literature heavily favors pragmatics concerns of language at the expense of considering underlying factors (syntax and semantics). The results support the use of language as a means of analyzing interactions between actors in communication intensive systems.

  4. Communications Blackout Predictions for Atmospheric Entry of Mars Science Laboratory (United States)

    Morabito, David D.; Edquist, Karl


    The Mars Science Laboratory (MSL) is expected to be a long-range, long-duration science laboratory rover on the Martian surface. MSL will provide a significant milestone that paves the way for future landed missions to Mars. NASA is studying options to launch MSL as early as 2009. MSL will be the first mission to demonstrate the new technology of 'smart landers', which include precision landing and hazard avoidance in order to -land at scientifically interesting sites that would otherwise be unreachable. There are three elements to the spacecraft; carrier (cruise stage), entry vehicle, and rover. The rover will have an X-band direct-to-Earth (DTE) link as well as a UHF proximity link. There is also a possibility of an X-band proximity link. Given the importance of collecting critical event telemetry data during atmospheric entry, it is important to understand the ability of a signal link to be maintained, especially during the period near peak convective heating. The received telemetry during entry (or played back later) will allow for the performance of the Entry-Descent-Landing technologies to be assessed. These technologies include guided entry for precision landing, hazard avoidance, a new sky-crane landing system and powered descent. MSL will undergo an entry profile that may result in a potential communications blackout caused by ionized plasma for short periods near peak heating. The vehicle will use UHF and possibly X-band during the entry phase. The purpose of this report is to quantify or bound the likelihood of any such blackout at UHF frequencies (401 MHz) and X-band frequencies (8.4 GHz). Two entry trajectory scenarios were evaluated: a stressful entry trajectory to quantify an upper-bound for any possible blackout period, and a nominal likely trajectory to quantify likelihood of blackout for such cases.


    Directory of Open Access Journals (Sweden)

    Roger Lee Mendoz


    Full Text Available BACKGROUND Unlike many other countries, only 19% of physicians remain independent or solo practitioners in the United States. This study seeks to determine if entry barriers to solo practice exist in physician services markets with a predominantly suburban patient base. Any entry barrier will play a critical role in a wide variety of competition and income-related issues in these markets. MATERIALS AND METHODS This study hypothesizes that substantial deterrence to entry is present in suburban settings where physician competition is typically much less than metropolitan areas. Information about their competitive position was obtained from solo primary care physicians (PCPs and specialists in southern New Jersey municipalities. Two-sample t - tests (α =0.05 ascertained whether the means differences of these two groups are statistically significant for the population from which they were sampled. Regression coefficients were computed for the magnitude of differences in barrier impact between samples. RESULTS Adapting the Orr model, E = ß0 e ß 1 (πp -π* e ß 2 Q . S ß 3 µ, to this study allowed us to estimate the overall height of entry barriers to suburban solo practice. The study finds that entry barriers tend to have moderate effects on PCPs, with the exception of legal and regulatory compliance which are just as burdensome to specialists. Risk and insurance, capital, advertising, research and development (R & D as well as market concentration are far more challenging to solo specialists mainly due to overuse of already costly tests, procedures, and medications by specialists for "defensive medicine," and heavy reliance on specialists by PCPs. Labor costs are associated with several barriers. CONCLUSION Despite their declining population, market entry (and presumably survival of solo physicians is not as straightforward of a phenomenon as conjectural and anecdotal evidence might suggest. Medical specialty offers an explanatory variable

  6. Atmospheric structure from Phoenix atmospheric entry data (United States)

    Catling, D. C.


    The atmospheric structure at the time of landing of NASA's Phoenix probe has been derived from measurements of the aerodynamic drag of the spacecraft during atmospheric entry and descent. The result provides the first atmospheric structure in Mars' polar environment obtained from in situ measurements. Phoenix was equipped with an inertial measurement unit (IMU) that used accelerometers for linear acceleration measurement in three Cartesian axes and ring-laser gyroscopes to measure the three- dimensional orientation of the probe (Taylor et al., 2008). The temperature structure of the atmosphere along the flight path was calculated via a four-step process: (i) integrating forward the IMU data to obtain the time history of the spacecraft velocity vector relative to the atmosphere as a function of altitude; (ii) calculating atmospheric density from drag, with iteration for aerodynamic coefficient dependence on density; (iii) integrating the hydrostatic equation to derive the vertical pressure; and (iv) calculating atmospheric temperature from the equation of state. Initial profile reconstruction shows reasonable agreement with predictions in the middle atmosphere for the given season and time of day (landing occurred at 16h 33min 37sec in local solar time expressed as a 24-hour clock). However, the derived lower atmospheric structure below ~0.1 mbar is generally warmer than predicted. A possible explanation could be a shallower vertical distribution of dust that usually assumed. References: P. A. Taylor, D. C. Catling, M. Daly, C. S. Dickinson, H. O. Gunnlaugsson, A-M. Harri, C. F. Lange, Temperature, pressure and wind instrumentation on the Phoenix meteorological package, J. Geophys. Res., 113, EA0A10, doi:10.1029/2007JE003015, 2008.

  7. Modulation of Calcium Entry by Mitochondria. (United States)

    Fonteriz, Rosalba; Matesanz-Isabel, Jessica; Arias-Del-Val, Jessica; Alvarez-Illera, Pilar; Montero, Mayte; Alvarez, Javier


    The role of mitochondria in intracellular Ca(2+) signaling relies mainly in its capacity to take up Ca(2+) from the cytosol and thus modulate the cytosolic [Ca(2+)]. Because of the low Ca(2+)-affinity of the mitochondrial Ca(2+)-uptake system, this organelle appears specially adapted to take up Ca(2+) from local high-Ca(2+) microdomains and not from the bulk cytosol. Mitochondria would then act as local Ca(2+) buffers in cellular regions where high-Ca(2+) microdomains form, that is, mainly close to the cytosolic mouth of Ca(2+) channels, both in the plasma membrane and in the endoplasmic reticulum (ER). One of the first targets proposed already in the 1990s to be regulated in this way by mitochondria were the store-operated Ca(2+) channels (SOCE). Mitochondria, by taking up Ca(2+) from the region around the cytosolic mouth of the SOCE channels, would prevent its slow Ca(2+)-dependent inactivation, thus keeping them active for longer. Since then, evidence for this mechanism has accumulated mainly in immunitary cells, where mitochondria actually move towards the immune synapse during T cell activation. However, in many other cell types the available data indicate that the close apposition between plasma and ER membranes occurring during SOCE activation precludes mitochondria from getting close to the Ca(2+)-entry sites. Alternative pathways for mitochondrial modulation of SOCE, both Ca(2+)-dependent and Ca(2+)-independent, have also been proposed, but further work will be required to elucidate the actual mechanisms at work. Hopefully, the recent knowledge of the molecular nature of the mitochondrial Ca(2+) uniporter will allow soon more precise studies on this matter.

  8. Comparable stocks, boundedly rational stock markets and IPO entry rates.

    Directory of Open Access Journals (Sweden)

    Jay Chok

    Full Text Available In this study, we examine how initial public offerings (IPO entry rates are affected when stock markets are boundedly rational and IPO firms infer information from their counterparts in the market. We hypothesize a curvilinear relationship between the number of comparable stocks and initial public offerings (IPO entry rates into the NASDAQ Stock Exchange. Furthermore, we argue that trading volume and changes in stock returns partially mediates the relationship between the number of comparable stocks and IPO entry rates. The statistical evidence provides strong support for the hypotheses.

  9. CIF and other mysteries of the store-operated Ca2+-entry pathway. (United States)

    Bolotina, Victoria M; Csutora, Peter


    The molecular mechanism of the store-operated Ca2+-entry (SOCE) pathway remains one of the most intriguing and long lasting mysteries of Ca2+ signaling. The elusive calcium influx factor (CIF) that is produced upon depletion of Ca2+ stores has attracted growing attention, triggered by new discoveries that filled the gap in the chain of reactions leading to activation of store-operated channels and Ca2+ entry. Ca2+-independent phospholipase A2 emerged as a target of CIF, and a major determinant of the SOCE mechanism. Here, we present our viewpoint on CIF and conformational-coupling models of SOCE from a historical perspective, trying to resolve some of the problem areas, and summarizing our present knowledge on how depletion of intracellular Ca2+ stores signals to plasma membrane channels to open and provide Ca2+ influx that is required for many important physiological functions.

  10. RITD - Adapting Mars Entry, Descent and Landing System for Earth (United States)

    Heilimo, Jyri; Harri, Ari-Matti; Aleksashkin, Sergey; Koryanov, Vsevolod; Arruego, Ignacio; Schmidt, Walter; Haukka, Harri; Finchenko, Valery; Martynov, Maxim; Ostresko, Boris; Ponomarenko, Andrey; Kazakovtsev, Viktor; Martin, Susanna; Siili, Tero


    A new generation of inflatable Entry, Descent and Landing System (EDLS) for Mars has been developed. It is used in both the initial atmospheric entry and atmospheric descent before the semi-hard impact of the penetrator into Martian surface. The EDLS applicability to Earth's atmosphere is studied by the EU/RITD [1] project. Project focuses to the analysis and tests of the transonic behaviour of this compact and light weight payload entry system at the Earth re-entry. 1. EDLS for Earth The dynamical stability of the craft is analysed, concentrating on the most critical part of the atmospheric re-entry, the transonic phase. In Martian atmosphere the MetNet vehicle stability during the transonic phase is understood. However, in the more dense Earth's atmosphere, the transonic phase is shorter and turbulence more violent. Therefore, the EDLS has to be sufficiently dynamically stable to overcome the forces tending to deflect the craft from its nominal trajectory and attitude. The preliminary design of the inflatable EDLS for Earth will be commenced once the scaling of the re-entry system and the dynamical stability analysis have been performed. The RITD-project concentrates on mission and applications achievable with the current MetNet-type (i.e. 'Mini-1' category) of lander, and on requirements posed by other type Earth re-entry concepts. 2. Entry Angle Determination for Mini-1 - lander For successful Earth landing, the suitable re-entry angle and velocity with specific descent vehicle (DV) mass and heat flux parameters need to be determined. These key parameters in determining the Earth re-entry for DV are: qmax (kW/m2): maximal specific heat flux, Q (MJ/m2): specific integral heat flux to DV front shield, m (kg): descent vehicle (DV) mass, V (m/s): re-entry velocity and Θ (deg.): flight-path angle at Earth re-entry For Earth re-entry, the calculation results in the optimal value of entry velocity for MetNet ('Mini-1' category) -type lander, with mass of 22kg, being

  11. Text entry rate of access interfaces used by people with physical disabilities: A systematic review. (United States)

    Koester, Heidi Horstmann; Arthanat, Sajay


    This study systematically reviewed the research on assistive technology (AT) access interfaces used for text entry, and conducted a quantitative synthesis of text entry rates (TER) associated with common interfaces. We searched 10 databases and included studies in which: typing speed was reported in words per minute (WPM) or equivalent; the access interface was available for public use; and individuals with physical impairments were in the study population. For quantitative synthesis, we used only the TER reported for individuals with physical impairments. Studies also had to report the sample size, and the average and standard deviation for the TER data. Thirty-nine studies met the criteria for quantitative synthesis. Studies involved seven interface types: standard keyboard typing, on-screen keyboard (OSK) with cursor selection, OSK with scanning selection, automatic speech recognition (ASR), Morse code, brain-computer interface (BCI), and other. ASR, standard keyboard, cursor OSK, and scanning OSK had at least four studies and 30 subjects, with TER averaging 15.4, 12.5, 4.2, and 1.7 WPM, respectively. When combined with measurements of a particular client's text entry performance, the TER from this review can be used within an evidence-based decision-making process for selecting control interfaces.

  12. [The entry of Epstein-Barr virus into B lymphocytes and epithelial cells during infection]. (United States)

    Zuo, Lie-Lian; Zhu, Mei-Juan; Du, Shu-Juan; Lu, Jian-Hong; Li, Gui-Yuan


    Epstein-Barr virus (EBV) is a human herpesvirus associated with important human diseases, including infectious mononucleosis syndrome, malignant lymphoma, and nasopharyngeal carcinoma. The mechanism of EBV entry into host cells remains a subject of intensive research. After decades of study, researchers have identified several key proteins and different patterns of EBV intrusion into host cells. The viral surface glycoproteins, gp350/220, gp42, gB, gH, and gL, are involved in interactions with the CR2 receptor on the surface of B lymphocytes during viral entry. However, the majority of epithelial cells lack CR2 receptor expression, which makes viral invasion much more complex than in B lymphocytes. Three different models have been proposed to explain how EBV enters epithelial cells: (1) "transfer of infection", mediated by B lymphocytes or Langerhans cells; (2) EBV utilizes its own proteins during the process of fusion with the cell membrane; and (3) progeny virions arising from EBV-infected epithelial cells cross lateral membranes into adjacent epithelial cells. This review will discuss the relevant mechanism of viral entry into B lymphocytes and epithelial cells during EBV infection.




    Acquisition performance of 22 rats in a straight alley runway was examined. The animals were subjected to partial reinforcement when the alley was black (B+/-) and continuous reinforcement when it was white (W+). The results indicated (a) higher terminal performance, for partial as against continuous reinforcement conditions, for starting-time and running-time measures, and (b) lower terminal performance under partial conditions for a goal-entry-time measure. These results confirm within subjects an effect previously demonstrated, in the runway, only in between-groups tests, where one group is run under partial reinforcement and a separate group is run under continuous reinforcement in the presence of the same external stimuli. Differences between the runway situation, employing a discrete-trial procedure and performance measures at three points in the response chain, and the Skinner box situation, used in its free-operant mode with a single performance measure, are discussed in relation to the present findings.

  14. The Design Process of Physical Security as Applied to a U.S. Border Port of Entry

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, G.G.


    This paper details the application of a standard physical security system design process to a US Border Port of Entry (PoE) for vehicle entry/exit. The physical security design methodology is described as well as the physical security similarities to facilities currently at a US Border PoE for vehicles. The physical security design process description includes the various elements that make up the methodologies well as the considerations that must be taken into account when dealing with system integration of those elements. The distinctions between preventing unlawful entry/exit of illegal contraband and personnel are described. The potential to enhance the functions of drug/contraband detection in the Pre-Primary Inspection area through the application of emerging technologies are also addressed.

  15. Moods of Norway: NY market entry


    Haugom, Mats Klevengen; Throne, Sindre Raaen; Myrseth, Sebastian; Løvoll, Linda-Marie


    Purpose The purpose of this document is to identify the key strategic and supplementary measures the Moods of Norway(MoN) management must take under consideration, to successfully penetrate the New York marketplace, more importantly stay there. Methodology In order to identify those areas of importance stated in the purpose, we looked at the several areas of importance such as the company´s history of expansion, identified business objectives for the New York launch, anal...

  16. Mini-Series on the Entry Level Debate. (United States)

    Fagan, Thomas K., Ed.; And Others


    Eight essays regarding the debate over establishment of the doctoral degree as a requirement for entry-level school psychologists are presented. Critical issues facing the National Association of School Psychologists and the American Psychological Association are considered. (TJH)

  17. Orion Entry Performance-Based Center-of-Gravity Box (United States)

    Rea, Jeremy R.


    The Orion capsule has many performance requirements for its atmospheric entry trajectory. Requirements on landing accuracy, maximum heating rate, total heat load, propellant usage, and sensed acceleration must all be satised. It is desired to define a methodology to translate the many performance requirements for an atmospheric entry trajectory into language easily understood by vehicle designers in terms of an allowable center-of-gravity box. This is possible by noting that most entry performance parameters for a capsule vehicle are mainly determined by the lift-to-drag ratio of the vehicle. However, the lift-to- drag ratio should be considered a probabilistic quantity rather than deterministic, where variations in the lift-to-drag are caused by both aerodynamic and center-of-gravity un- certainties. This paper discusses the technique used by the Orion program to define the allowable dispersions in center-of-gravity to achieve the desired entry performance while accounting for aerodynamic uncertainty.

  18. Forecast and capacity planning for Nogales' ports of entry : [summary]. (United States)


    This document provides the final report of the activities performed under the project : Nogales POEs Traffic Study: Forecast and Capacity Planning for Nogales Ports of Entry : sponsored by the Arizona Department of Transportation (ADOT) under Gran...

  19. 19 CFR 122.26 - Entry and clearance. (United States)


    ... AIR COMMERCE REGULATIONS Private Aircraft § 122.26 Entry and clearance. Private aircraft, as defined... information as set forth in § 122.22(c), and grants electronic clearance via electronic mail or telephone. ...

  20. Entry and Exit Dynamics of Nascent Business Owners

    DEFF Research Database (Denmark)

    Rocha, Vera; Carneiro, Anabela; Varum, Celeste


    This paper reports a comprehensive study on the dynamics of nascent business owners using a unique longitudinal matched employer–employee dataset. We follow over 157,000 individuals who leave paid employment and become business owners during the period 1992–2007. The contributions of this paper...... are twofold. First, we analyze both entry and exit, identifying and characterizing different profiles of individuals leaving paid employment to become business owners, and distinguishing exits by dissolution from exits by ownership transfer. Second, we provide new evidence on how particular experiences...... in the labor market and entry modes shape the post-entry dynamics of nascent business owners. By differentiating between different entry and exit routes, this paper provides new evidence on different human capital patterns among nascent business owners and on key determinants of entrepreneurial survival. Our...

  1. The state-of-the-art port of entry workshop

    Energy Technology Data Exchange (ETDEWEB)

    Godfrey, B.


    The increased demand for freight movements through international ports of entry and the signing of the North American Free Trade Agreement (NAFTA) have increased freight traffic at border ports of entry. The State-of-the-Art Port of Entry Workshop initiated a dialogue among technologists and stakeholders to explore the potential uses of technology at border crossings and to set development priorities. International ports of entry are both information and labor intensive, and there are many promising technologies that could be used to provide timely information and optimize inspection resources. Participants universally held that integration of technologies and operations is critical to improving port services. A series of Next Steps was developed to address stakeholder issues and national priorities, such as the National Transportation Policy and National Drug Policy. This report documents the views of the various stakeholders and technologists present at the workshop and outlines future directions of study.

  2. AIRLINE COMPETITION: Barriers to Entry Continue in Some Domestic Markets

    National Research Council Canada - National Science Library


    .... Airline deregulation has led to lower fares and better service for most air travelers largely because of increased competition spurred by the entry of new airlines into the industry and established...

  3. 40 CFR 89.506 - Right of entry and access. (United States)


    ... conduct activities related to entry and access as authorized in this section only upon the consent of the... manufacturer is responsible for locating its foreign testing and manufacturing facilities in jurisdictions...

  4. Advanced Metal Rubber Sensors for Hypersonic Decelerator Entry Systems Project (United States)

    National Aeronautics and Space Administration — NanoSonic proposes to design and develop light-weight, low-modulus, and durable Metal Rubber™ sensors for aeroelastic analysis of Hypersonic Decelerator Entry...

  5. Multidisciplinary Design Under Uncertainty for Entry Vehicles Project (United States)

    National Aeronautics and Space Administration — The physical difficulty of designing entry vehicles originates from the large degree of coupling between the various disciplines involved in the design. Every...

  6. The choice of foreign entry modes in a control perspective

    DEFF Research Database (Denmark)

    Boyd, Britta; Dyhr Ulrich, Anna Marie; Hollensen, Svend

    depending on the control that the company has over its activities abroad. The paper examines selected factors that influence the ‘entry modes’ of Danish SMEs in different strategic settings. Results show that the most deciding factor for the choice of high control entry mode (subsidiary) was the factor...... turnover. The factors: personal networks and the interruption of the international activities were the most significant factors for the choice of intermediate mode (joint ventures and strategic alliances).......The aim of this article is to investigate the choice of entry modes for international markets in a control perspective. A survey from The Confederation of Danish Industry with 234 Danish small- and medium sized enterprises served as a data base. The entry modes are categorized into three groups...

  7. Mexican Immigration and the Port-of-Entry School. (United States)

    Baca, Reynaldo; And Others


    Results of immigrant student census data are used to describe school entry patterns and educational backgrounds of Mexican immigrant students. Interviews with recently arrived immigrant parents reveal educational and occupational expectations. Research and policy implications are discussed. (MW)

  8. 7 CFR 319.41-5 - Condition of entry. (United States)


    ... be made safe by sterilization or other treatment, the entire shipment may be refused entry. (b) When... safeguards and by routing prescribed by the inspector to an approved port where facilities for sterilization...

  9. International Energy: Subject Thesaurus

    Energy Technology Data Exchange (ETDEWEB)

    Raridon, M.H. (ed.)


    The International Energy Subject Thesaurus contains the standard vocabulary to indexing terms (descriptors) developed and structured to build and maintain energy information databases. Involved in this cooperative task are (1) the technical staff of the USDOE Office of Scientific and Technical Information (OSTI) in cooperation with the member countries of the Energy Technology Data Exchange (ETDE) and (2) the International Nuclear Information System (INIS) staff representing the more than ninety countries and organizations recording and indexing information for the international nuclear information community. ETDE member countries are also members of the International Nuclear Information System (INIS). Nuclear information indexed and recorded for INIS by these ETDE member countries is also included in the ETDE Energy Data Base, and indexing terminology is therefore cooperatively standardized for use in both information systems. This structured vocabulary reflects the scope of international energy research, development, and technological programs and encompasses terminology derived not only from the basic sciences but also from the areas of energy resources, conservation, safety, environmental impact, and regulation.

  10. Newly designed launch and entry suit (LES) modeled by technician (United States)


    Space shuttle orange launch and entry suit (LES), a partial pressure suit, is modeled by a technician. LES was designed for STS-26, the return to flight mission, and subsequent missions. Included in the crew escape system (CES) package are launch and entry helmet (LEH) with communications carrier (COMM CAP), parachute pack and harness, life raft, life preserver unit (LPU), LES gloves, suit oxygen manifold and valves, boots, and survival gear.

  11. Principles of safe abdominal entry in laparoscopic gynecologic surgery

    Directory of Open Access Journals (Sweden)

    Jongrak Thepsuwan


    Full Text Available Laparoscopic gynecologic surgery has been widely used with a range of benefits. However, there are complications that are related to the abdominal entry process. Serious complications are gastrointestinal tract and major blood vessel injuries. This review introduces the recent available literature to prevent and eliminate the laparoscopic entry complications. The open entry technique is associated with a significant reduction of failed entry, compared to the closed entry technique; however there is no difference in the incidence of visceral or vascular injury. Laparoscopic entry by the left upper abdomen (i.e., Palmer's point or the middle upper abdomen (i.e., the Lee-Huang point could be considered in patients with suspected periumbilical adhesions or a history of umbilical hernia, or after three failed attempts of insufflation at the umbilicus. The Lee-Huang point has its own benefit for the operative laparoscopy in large pelvic pathologies and gynecology malignancy cases. The angle of Veress needle insertion varies from 45° in nonobese women to 90° in extraordinarily obese women. The high intra-peritoneal pressure entries, which range from 20 mmHg to 25 mmHg, minimize the risk of vascular injury. Therefore, this will not adversely affect the cardiopulmonary function in healthy women. The Veress intraperitoneal pressure (<10 mmHg is a reliable indicator of correct intraperitoneal placement of the Veress needle. The elevation of anterior abdominal wall for placement of a Veress needle increases the risks of failed entry and shows no advantage in regard to vascular or visceral complications. Surgeons should continue to increase their knowledge of anatomy, their training, and their experience to decrease laparoscopic complications.

  12. Can Small Entry Barriers Have Large Effects on Competition?


    Seabright, Paul


    One of the main aims of the deregulation of previously heavily regulated markets is to diminish artificial barriers to entry. But in oligopolistic markets, the mechanisms whereby potential competition can discipline the behaviour of incumbent firms are not very well understood, especially since pricing responses to entry can typically be very rapid. This paper develops a model in which potential competition has no direct effect upon the pricing behaviour of incumbents, but affects the extent ...

  13. The entry price threshold in EU agriculture: deterrent or barrier?


    Santeramo, Fabio Gaetano; Cioffi, Antonio


    The paper investigates the effects of the entry price scheme for fresh fruit and vegetables. The analysis is conducted on the European prices of tomatoes, lemons and apples for some of the main competing countries on the European domestic markets: Morocco, Argentina, Turkey and China. The econometric analysis is based on testing and estimating a switching vector autoregressive model with endogenous threshold entry price level. The model shows the isolation effects and the accumulation of Sta...

  14. Modeling global franchising in emerging markets: An entry mode analysis


    Baena Graciá, Verónica


    Emerging markets are some of the fastest-growing economies in the world because of their substantial economic transformation. Nevertheless, little is known about the factors influencing choices of foreign entry mode into those markets. In an attempt to expand knowledge of this topic, this article presents an empirical assessment of the relationship between a set of variables and the four possible entry modes franchisors can adopt: direct franchising, master franchising, joint venture, and dir...

  15. Predictors of student success in entry-level science courses (United States)

    Singh, Mamta K.

    Although the educational evaluation process is useful and valuable and is supported by the Higher Education Act, a strong research base for program evaluation of college entry-level science courses is still lacking. Studies in science disciplines such as, biology, chemistry, and physics have addressed various affective and demographic factors and their relationships to student achievement. However, the literature contains little information that specifically addresses student biology content knowledge skills (basics and higher order thinking skills) and identifies factors that affect students' success in entry-level college science courses. These gate-keeping courses require detailed evaluation if the goal of an institution is to increase students' performance and success in these courses. These factors are, in fact, a stepping stone for increasing the number of graduates in Science, Technology, Engineering, and Mathematics (STEM) majors. The present study measured students' biology content knowledge and investigated students' performance and success in college biology, chemistry, and physics entry-level courses. Seven variables---gender, ethnicity, high school Grade Point Average (GPA), high school science, college major, school financial aid support, and work hours were used as independent variables and course final performance as a dichotomous dependent variable. The sample comprised voluntary student participants in entry-level science courses. The study attempted to explore eight research questions. Content knowledge assessments, demographic information analysis, multiple regression analysis, and binary logistic regression analysis were used to address research questions. The results suggested that high school GPA was a consistently good predictor of students' performance and success in entry-level science courses. Additionally, high school chemistry was a significant predictor variable for student success in entry-level biology and chemistry courses

  16. Institutions, resources, and entry strategies in emerging economies


    Klaus E Meyer; Estrin, Saul; Bhaumik, Sumon; Peng, Mike W.


    We investigate the impact of market-supporting institutions on business strategies by analyzing the entry strategies of foreign investors entering emerging economies. We apply and advance the institutions-based view of strategy by integrating it with resource-based considerations. In particular, we show how resource-seeking strategies are pursued using different entry modes in different institutional contexts. Alternative modes of entry— greenfield, acquisition, and joint venture (JV)—allo...

  17. Stagnation Point Radiative Heating Relations for Venus Entry (United States)

    Tauber, Michael E.; Palmer, Grant E.; Prabhu, Dinesh K.


    Improved analytic expressions for calculating the stagnation point radiative heating during entry into the atmosphere of Venus have been developed. These analytic expressions can be incorporated into entry trajectory simulation codes. Together with analytical expressions for convective heating at the stagnation point, the time-integrated total heat load at the stagnation point is used in determining the thickness of protective material required, and hence the mass of the fore body heatshield of uniform thickness.

  18. Entry of Wal-Mart Supercenters and Supermarkets’ Profit Margins


    Xiaoou Liu; Rigoberto A. Lopez


    This article quantifies the impact of Wal-Mart Supercenters on supermarkets’ profitability via a two-stage dynamic entry game, using method of simulated moments and milk scanner data from Dallas/Fort Worth supermarkets. The empirical findings show that the entry of Wal-Mart Supercenters accounts for about an average 50% decrease in milk profit margins for incumbent supermarkets. Effects of scale are found to be more significant for Wal-Mart Supercenters than for incumbent supermarkets, granti...

  19. Factors Influencing Choice of Occupational Area among Technical ...

    African Journals Online (AJOL)

    Factors Influencing Choice of Occupational Area among Technical Education Students with Differing Entry Qualifications. ... Interest in study area; perceived availability of job opportunities related to area of specialization; simplicity of area in training and in employment; and perceived affordability of equipment for ...

  20. Acceptions of the "death"entry in language dictionaries

    Directory of Open Access Journals (Sweden)

    Jessica Camara Siqueira


    Full Text Available Language dictionaries present the meaning of an entry in a way not restricted to linguistic information, since we also have interdisciplinary and contextual aspects that dialogue with socio-cultural issues in which the entry is inserted. Considering the potential character of the study of contextual meanings, the “death” entry was chosen to carry out a comparative analysis among language dictionaries. The choice was motivated by the recurrence of this entry in ancient and contemporary dictionaries, and the fact of its having a concept that allows various historical, social and ideological discussions. The goal is to reveal the different nuances of the “death” entry in language dictionaries, observing four main aspects: etymology, diachrony, synonymic construction and meaning of “death” in school dictionaries. Based on lexicographical studies of classical authors, we did a comparative analysis of meanings of “death” in different types of language dictionaries. We found that in each group dictionary we may find traces of ideological choices in the construction of the contextual meaning of the “death” entry.

  1. Using analytic network process for evaluating mobile text entry methods. (United States)

    Ocampo, Lanndon A; Seva, Rosemary R


    This paper highlights a preference evaluation methodology for text entry methods in a touch keyboard smartphone using analytic network process (ANP). Evaluation of text entry methods in literature mainly considers speed and accuracy. This study presents an alternative means for selecting text entry method that considers user preference. A case study was carried out with a group of experts who were asked to develop a selection decision model of five text entry methods. The decision problem is flexible enough to reflect interdependencies of decision elements that are necessary in describing real-life conditions. Results showed that QWERTY method is more preferred than other text entry methods while arrangement of keys is the most preferred criterion in characterizing a sound method. Sensitivity analysis using simulation of normally distributed random numbers under fairly large perturbation reported the foregoing results reliable enough to reflect robust judgment. The main contribution of this paper is the introduction of a multi-criteria decision approach in the preference evaluation of text entry methods. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  2. Store-operated calcium entry and increased endothelial cell permeability. (United States)

    Norwood, N; Moore, T M; Dean, D A; Bhattacharjee, R; Li, M; Stevens, T


    We hypothesized that myosin light chain kinase (MLCK) links calcium release to activation of store-operated calcium entry, which is important for control of the endothelial cell barrier. Acute inhibition of MLCK caused calcium release from inositol trisphosphate-sensitive calcium stores and prevented subsequent activation of store-operated calcium entry by thapsigargin, suggesting that MLCK serves as an important mechanism linking store depletion to activation of membrane calcium channels. Moreover, in voltage-clamped single rat pulmonary artery endothelial cells, thapsigargin activated an inward calcium current that was abolished by MLCK inhibition. F-actin disruption activated a calcium current, and F-actin stabilization eliminated the thapsigargin-induced current. Thapsigargin increased endothelial cell permeability in the presence, but not in the absence, of extracellular calcium, indicating the importance of calcium entry in decreasing barrier function. Although MLCK inhibition prevented thapsigargin from stimulating calcium entry, it did not prevent thapsigargin from increasing permeability. Rather, inhibition of MLCK activity increased permeability that was especially prominent in low extracellular calcium. In conclusion, MLCK links store depletion to activation of a store-operated calcium entry channel. However, inhibition of calcium entry by MLCK is not sufficient to prevent thapsigargin from increasing endothelial cell permeability.

  3. Effects ok ikea's entry into a furniture production cluster

    Directory of Open Access Journals (Sweden)

    Vasco Eiriz


    Full Text Available The entry of a multinational into a cluster, a geographic agglomeration in a given place or region of predominantly small and medium enterprises specialized in a given industry or related industries, impacts the incumbent in the cluster. Aiming to identify the main effects of a multinational entry on the firms’ strategy in a cluster, it was analyzed the entry of IKEA, a Swedish multinational, into the cluster of furniture production in Paços de Ferreira and Paredes, in Portugal. In this study, the data collection technique to access primary data was a survey. The sample has small enterprises, which is similar to the structure of firms in the studied cluster. Results show that more than half the sample thinks that the entry of the multinational had not affected them. However, the firms that acknowledge a significant impact, assess that impact as negative. The competitiveness factors that have improved more significantly after IKEA’s entry were new product development and exporting strategies. The main responses of incumbent firms to the multinational entry were internationalization and the development of generic strategies of differentiation and focus based on differentiation.

  4. Exploiting Herpes Simplex Virus Entry for Novel Therapeutics

    Directory of Open Access Journals (Sweden)

    Deepak Shukla


    Full Text Available Herpes Simplex virus (HSV is associated with a variety of diseases such as genital herpes and numerous ocular diseases. At the global level, high prevalence of individuals who are seropositive for HSV, combined with its inconspicuous infection, remains a cause for major concern. At the molecular level, HSV entry into a host cell involves multiple steps, primarily the interaction of viral glycoproteins with various cell surface receptors, many of which have alternate substitutes. The molecular complexity of the virus to enter a cell is also enhanced by the existence of different modes of viral entry. The availability of many entry receptors, along with a variety of entry mechanisms, has resulted in a virus that is capable of infecting virtually all cell types. While HSV uses a wide repertoire of viral and host factors in establishing infection, current therapeutics aimed against the virus are not as diversified. In this particular review, we will focus on the initial entry of the virus into the cell, while highlighting potential novel therapeutics that can control this process. Virus entry is a decisive step and effective therapeutics can translate to less virus replication, reduced cell death, and detrimental symptoms.

  5. An audit of aerodynamic loss in a double entry turbine under full and partial admission

    Energy Technology Data Exchange (ETDEWEB)

    Newton, Peter, E-mail: [Department of Mechanical Engineering, Imperial College London, London (United Kingdom); Copeland, Colin, E-mail: [Department of Mechanical Engineering, Imperial College London, London (United Kingdom); Martinez-Botas, Ricardo, E-mail: [Department of Mechanical Engineering, Imperial College London, London (United Kingdom); Seiler, Martin, E-mail: [ABB Turbo Systems Ltd., Baden (Switzerland)


    Highlights: Black-Right-Pointing-Pointer A study of the loss inside a mixed flow, double entry turbocharger turbine. Black-Right-Pointing-Pointer Both full and partial admission conditions are discussed and compared. Black-Right-Pointing-Pointer Under partial admission the rotor wheel was found to act in a fully unsteady manner. Black-Right-Pointing-Pointer The inter-space region was a major area of loss generation under partial admission. - Abstract: The current study investigates the sources of loss inside a mixed flow, double entry turbocharger turbine under steady inlet conditions in both full and partial admission. Under normal on-engine operation, it is likely that both limbs in a double entry device will be fed by exhaust pulsations which are out of phase meaning that the turbine will spend most or all of the time with unbalanced flow through each limb. In the extreme case one limb will be flowing whilst the other is stagnant, this is the partial admission condition. Even under steady state inlet conditions, unequal admission is an important effect to study on the way to fully understanding pulsed operation of a double entry device. This paper presents 3D computational analyses of the flow inside a double entry turbine under both full and partial admission. The computational results are compared to experimental results of and . The distribution of loss within the turbine is evaluated for each computational condition by means of entropy production. In the full admission case the most significant area of loss was found to be in the tip region. Under the partial admission condition the flow regime is very different. In this case the rotor wheel was found to be acting in a fully unsteady manner, with the flow being unable to reach a fully developed state throughout the flowing section of the volute. The most significant area of entropy generation in the partial admission case was associated with interaction of the flows in each sector of the volute, this

  6. A subjective scheduler for subjective dedicated networks (United States)

    Suherman; Fakhrizal, Said Reza; Al-Akaidi, Marwan


    Multiple access technique is one of important techniques within medium access layer in TCP/IP protocol stack. Each network technology implements the selected access method. Priority can be implemented in those methods to differentiate services. Some internet networks are dedicated for specific purpose. Education browsing or tutorial video accesses are preferred in a library hotspot, while entertainment and sport contents could be subjects of limitation. Current solution may use IP address filter or access list. This paper proposes subjective properties of users or applications are used for priority determination in multiple access techniques. The NS-2 simulator is employed to evaluate the method. A video surveillance network using WiMAX is chosen as the object. Subjective priority is implemented on WiMAX scheduler based on traffic properties. Three different traffic sources from monitoring video: palace, park, and market are evaluated. The proposed subjective scheduler prioritizes palace monitoring video that results better quality, xx dB than the later monitoring spots.

  7. Energy data base: subject thesaurus

    Energy Technology Data Exchange (ETDEWEB)

    Redford, J.S. (ed.)


    The technical staff of the DOE Technical Information Center, during its subject indexing activities, develops and structures a vocabulary that allows consistent machine storage and retrieval of information necessary to the accomplishment of the DOE mission. This thesaurus incorporates that structured vocabulary. The terminology of this thesaurus is used for the subject control of information announced in DOE Energy Research Abstracts, Energy Abstracts for Policy Analysis, and various update journals and bulletins in specialized areas. This terminology also facilitates subject searching of the DOE Energy Data Base on the DOE/RECON on-line retrieval system and on other commercial retrieval systems. The rapid expansion of the DOE's activities will result in a commitant thesaurus expansion as information relating to new activities is indexed. Only the terms used in the indexing of documents at the Technical Information Center to date are included. (JSR)

  8. Requirements on Atmospheric Entry of Small Probes for Several Planets: Venus, Saturn, Neptune and Uranus in Preparation for the Future ESA Cosmic Vision Missions (United States)

    Tomuta, D.; Rebuffat, D.; Larranaga, J.; Erd, C.; Bavdaz, M.; Falkner, P.


    In preparation for the ESA Cosmic Vision new call for medium class missions, a set of entry probes for inner and outer planets have been preliminary investigated by ESA using its Concurrent Design Facility. These Entry Probe missions are hypothetically assumed for launching time 2020-2035. A preliminary design of the probes arrived at a mass of about 300kg. In the following, the study is focused on the entry conditions for each of the planets Venus, Saturn, Neptune and Uranus with the aim to define the conditions for the Entry and Descent System (EDS) and its required technologies. For Venus case, two scenarios where considered: one where the entry probe is released during a typical gravity assist by a large interplanetary mission and another scenario featuring a stand alone mission targeted to Venus. During the entry in Venus atmosphere (mainly composed of CO2 (96.5%) and N2 (3.5%)), the probes are subjected to maximum heat fluxes of 60MW/m2, which is highly demanding in both scenarios. For the outer planet missions, only flyby scenarios with a targeted release of the probe were considered. The entry probes for the outer planets are subjected to heat fluxes above 100MW/m2, which is even more challenging the Thermal Protection Systems (TPS) and therefore requiring the use of special high temperature protection technology to prevent the destruction during the entry. ESA efforts for future missions are directed towards the development of an European Light Ablative Material (ELAM), though used in PEP study only for the Back Cover of the Entry Module. The TPS as well as both radiative and convective heat fluxes need simulations and verification by means of ground facility experiments. Based on the lessons learned from previous mission studies (mission to a near-Earth objects c.f. Marco Polo, Deimos Sample return), an Atmospheric Mars Sample Return is now under study. For sample return missions on return to Earth, a passive re-entry capsule delivering the sample

  9. Numerical Study of Flow Augmented Thermal Management for Entry and Re-Entry Environments (United States)

    Cheng, Gary C.; Neroorkar, Kshitij D.; Chen, Yen-Sen; Wang, Ten-See; Daso, Endwell O.


    The use of a flow augmented thermal management system for entry and re-entr environments is one method for reducing heat and drag loads. This concept relies on jet penetration from supersonic and hypersonic counterflowing jets that could significantly weaken and disperse the shock-wave system of the spacecraft flow field. The objective of this research effort is to conduct parametric studies of the supersonic flow over a 2.6% scale model of the Apollo capsule, with and without the counterflowing jet, using time-accurate and steady-state computational fluid dynamics simulations. The numerical studies, including different freestream Mach number angle of attack counterflowing jet mass flow rate, and nozzle configurations, were performed to examine their effect on the drag and beat loads and to explore the counternowing jet condition. The numerical results were compared with the test data obtained from transonic blow-down wind-tunnel experiments conducted independently at NASA MSFC.

  10. Virus entry. Lassa virus entry requires a trigger-induced receptor switch. (United States)

    Jae, Lucas T; Raaben, Matthijs; Herbert, Andrew S; Kuehne, Ana I; Wirchnianski, Ariel S; Soh, Timothy K; Stubbs, Sarah H; Janssen, Hans; Damme, Markus; Saftig, Paul; Whelan, Sean P; Dye, John M; Brummelkamp, Thijn R


    Lassa virus spreads from a rodent to humans and can lead to lethal hemorrhagic fever. Despite its broad tropism, chicken cells were reported 30 years ago to resist infection. We found that Lassa virus readily engaged its cell-surface receptor α-dystroglycan in avian cells, but virus entry in susceptible species involved a pH-dependent switch to an intracellular receptor, the lysosome-resident protein LAMP1. Iterative haploid screens revealed that the sialyltransferase ST3GAL4 was required for the interaction of the virus glycoprotein with LAMP1. A single glycosylated residue in LAMP1, present in susceptible species but absent in birds, was essential for interaction with the Lassa virus envelope protein and subsequent infection. The resistance of Lamp1-deficient mice to Lassa virus highlights the relevance of this receptor switch in vivo. Copyright © 2014, American Association for the Advancement of Science.

  11. Entry-Level Activities in System Consultation (United States)

    Hylander, Ingrid


    System-level consultation or organizational development in schools is an area in great need of theoretical models and definitions. The three articles in this special issue provide a unique learning opportunity not only for consultation across borders but also for consultation within the same nation. In my commentary, I limit my remarks to a few…

  12. Atmospheric entry of nuclear-powered vehicles due to accidental/inadvertent termination of operations (United States)

    Menees, Gene P.; Park, Chul; Tauber, Michael E.


    The entries of the radioactive components into earth's atmosphere resulting from an accident or inadvertent abort of a space vehicle powered by nuclear-thermal-rockets are investigated. The study is made for a typical piloted Mars mission vehicle incapacitated by an accident or malfunction during the trans-Mars-injection maneuver due to simultaneous multiple failures of its component systems. The three different accident/abort modes considered are the following: (1) a constant-rate angular pitching motion of the vehicle, (2) a constant-acceleration angular pitching motion of the vehicle, and (3) the rocket engine breaks away from the rest of the vehicle with a finite relative (dispersion) velocity. The speeds and angles of the atmospheric entries are calculated for each mode for different values of the time of the accident, pitching rate, acceleration, and dispersion velocity. For the most severe entry speeds and flight-path angles, the stagnation-point pressures, heat transfer rates, thickness, and mass per unit area of the heat shields necessary to protect the radioactive components from disintegrating, deceleration g-loads, and high ground-impact velocities are calculated. The study points out that the high g-loads and high ground-impact velocities are the most serious problems that must be addressed.

  13. Costing conservation: an expert appraisal of the pollinator habitat benefits of England's entry level stewardship. (United States)

    Breeze, T D; Bailey, A P; Balcombe, K G; Potts, S G


    Pollination services provided by insects play a key role in English crop production and wider ecology. Despite growing evidence of the negative effects of habitat loss on pollinator populations, limited policy support is available to reverse this pressure. One measure that may provide beneficial habitat to pollinators is England's entry level stewardship agri-environment scheme. This study uses a novel expert survey to develop weights for a range of models which adjust the balance of Entry Level Stewardship options within the current area of spending. The annual costs of establishing and maintaining these option compositions were estimated at £59.3-£12.4 M above current expenditure. Although this produced substantial reduction in private cost:benefit ratios, the benefits of the scheme to pollinator habitat rose by 7-140 %; significantly increasing the public cost:benefit ratio. This study demonstrates that the scheme has significant untapped potential to provide good quality habitat for pollinators across England, even within existing expenditure. The findings should open debate on the costs and benefits of specific entry level stewardship management options and how these can be enhanced to benefit both participants and biodiversity more equitably.

  14. Challenges to Computational Aerothermodynamic Simulation and Validation for Planetary Entry Vehicle Analysis (United States)

    Gnoffo, Peter A.; Johnston, Christopher O.; Kleb, Bil


    Challenges to computational aerothermodynamic (CA) simulation and validation of hypersonic flow over planetary entry vehicles are discussed. Entry, descent, and landing (EDL) of high mass to Mars is a significant driver of new simulation requirements. These requirements include simulation of large deployable, flexible structures and interactions with reaction control system (RCS) and retro-thruster jets. Simulation of radiation and ablation coupled to the flow solver continues to be a high priority for planetary entry analyses, especially for return to Earth and outer planet missions. Three research areas addressing these challenges are emphasized. The first addresses the need to obtain accurate heating on unstructured tetrahedral grid systems to take advantage of flexibility in grid generation and grid adaptation. A multi-dimensional inviscid flux reconstruction algorithm is defined that is oriented with local flow topology as opposed to grid. The second addresses coupling of radiation and ablation to the hypersonic flow solver--flight- and ground-based data are used to provide limited validation of these multi-physics simulations. The third addresses the challenges of retro-propulsion simulation and the criticality of grid adaptation in this application. The evolution of CA to become a tool for innovation of EDL systems requires a successful resolution of these challenges.

  15. Quality of data entry using single entry, double entry and automated forms processing--an example based on a study of patient-reported outcomes

    DEFF Research Database (Denmark)

    Paulsen, Aksel; Overgaard, Søren; Lauritsen, Jens Martin


    The clinical and scientific usage of patient-reported outcome measures is increasing in the health services. Often paper forms are used. Manual double entry of data is defined as the definitive gold standard for transferring data to an electronic format, but the process is laborious. Automated...

  16. An Automated Method to Compute Orbital Re-Entry Trajectories with Heating Constraints (United States)

    Zimmerman, Curtis; Dukeman, Greg; Hanson, John; Fogle, Frank R. (Technical Monitor)


    Determining how to properly manipulate the controls of a re-entering re-usable launch vehicle (RLV) so that it is able to safely return to Earth and land involves the solution of a two-point boundary value problem (TPBVP). This problem, which can be quite difficult, is traditionally solved on the ground prior to flight. If necessary, a nearly unlimited amount of time is available to find the "best" solution using a variety of trajectory design and optimization tools. The role of entry guidance during flight is to follow the pre-determined reference solution while correcting for any errors encountered along the way. This guidance method is both highly reliable and very efficient in terms of onboard computer resources. There is a growing interest in a style of entry guidance that places the responsibility of solving the TPBVP in the actual entry guidance flight software. Here there is very limited computer time. The powerful, but finicky, mathematical tools used by trajectory designers on the ground cannot in general be made to do the job. Nonconvergence or slow convergence can result in disaster. The challenges of designing such an algorithm are numerous and difficult. Yet the payoff (in the form of decreased operational costs and increased safety) can be substantial. This paper presents an algorithm that incorporates features of both types of guidance strategies. It takes an initial RLV orbital re-entry state and finds a trajectory that will safely transport the vehicle to a Terminal Area Energy Management (TAEM) region. During actual flight, the computed trajectory is used as the reference to be flown by a more traditional guidance method.

  17. Improving laboratory data entry quality using Six Sigma. (United States)

    Elbireer, Ali; Le Chasseur, Julie; Jackson, Brooks


    The Uganda Makerere University provides clinical laboratory support to over 70 clients in Uganda. With increased volume, manual data entry errors have steadily increased, prompting laboratory managers to employ the Six Sigma method to evaluate and reduce their problems. The purpose of this paper is to describe how laboratory data entry quality was improved by using Six Sigma. The Six Sigma Quality Improvement (QI) project team followed a sequence of steps, starting with defining project goals, measuring data entry errors to assess current performance, analyzing data and determining data-entry error root causes. Finally the team implemented changes and control measures to address the root causes and to maintain improvements. Establishing the Six Sigma project required considerable resources and maintaining the gains requires additional personnel time and dedicated resources. After initiating the Six Sigma project, there was a 60.5 percent reduction in data entry errors from 423 errors a month (i.e. 4.34 Six Sigma) in the first month, down to an average 166 errors/month (i.e. 4.65 Six Sigma) over 12 months. The team estimated the average cost of identifying and fixing a data entry error to be $16.25 per error. Thus, reducing errors by an average of 257 errors per month over one year has saved the laboratory an estimated $50,115 a year. The Six Sigma QI project provides a replicable framework for Ugandan laboratory staff and other resource-limited organizations to promote quality environment. Laboratory staff can deliver excellent care at a lower cost, by applying QI principles. This innovative QI method of reducing data entry errors in medical laboratories may improve the clinical workflow processes and make cost savings across the health care continuum.

  18. Brain correlates of subjective freedom of choice (United States)

    Filevich, Elisa; Vanneste, Patricia; Brass, Marcel; Fias, Wim; Haggard, Patrick; Kühn, Simone


    The subjective feeling of free choice is an important feature of human experience. Experimental tasks have typically studied free choice by contrasting free and instructed selection of response alternatives. These tasks have been criticised, and it remains unclear how they relate to the subjective feeling of freely choosing. We replicated previous findings of the fMRI correlates of free choice, defined objectively. We introduced a novel task in which participants could experience and report a graded sense of free choice. BOLD responses for conditions subjectively experienced as free identified a postcentral area distinct from the areas typically considered to be involved in free action. Thus, the brain correlates of subjective feeling of free action were not directly related to any established brain correlates of objectively-defined free action. Our results call into question traditional assumptions about the relation between subjective experience of choosing and activity in the brain’s so-called voluntary motor areas. PMID:24021855

  19. 50 CFR 26.27 - Exception for entry on designated routes of travel. (United States)


    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Exception for entry on designated routes of travel. 26.27 Section 26.27 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) THE NATIONAL WILDLIFE REFUGE SYSTEM PUBLIC ENTRY AND USE Public Entry § 26.27 Exception for entry on designated...

  20. 19 CFR 144.12 - Contents of entry summary; estimated duties. (United States)


    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Contents of entry summary; estimated duties. 144... Procedures for Warehouse Entry § 144.12 Contents of entry summary; estimated duties. The entry summary, Customs Form 7501, shall show the value, classification, and rate of duty as approved by the port director...

  1. 19 CFR 144.42 - Combined entry for rewarehouse and withdrawal for consumption. (United States)


    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Combined entry for rewarehouse and withdrawal for consumption. 144.42 Section 144.42 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND... applicable to this type of entry, with the following exceptions: (1) Form of entry. A combined entry for...

  2. Bovine parvovirus uses clathrin-mediated endocytosis for cell entry. (United States)

    Dudleenamjil, Enkhmart; Lin, Chin-Yo; Dredge, Devin; Murray, Byron K; Robison, Richard A; Johnson, F Brent


    Entry events of bovine parvovirus (BPV) were studied. Transmission electron micrographs of infected cells showed virus particles in cytoplasmic vesicles. Chemical inhibitors that block certain aspects of the cellular machinery were employed to assess viral dependency upon those cellular processes. Chlorpromazine, ammonium chloride, chloroquine and bafilamicin A1 were used to inhibit acidification of endosomes and clathrin-associated endocytosis. Nystatin was used as an inhibitor of the caveolae pathway. Cytochalasin D and ML-7 were used to inhibit actin and myosin functions, respectively. Nocodazole and colchicine were employed to inhibit microtubule activity. Virus entry was assessed by measuring viral transcription using real-time PCR, synthesis of capsid protein and assembly of infectious progeny virus in the presence of inhibitor blockage. The results indicated that BPV entry into embryonic bovine trachael cells utilizes endocytosis in clathrin-coated vesicles, is dependent upon acidification, and appears to be associated with actin and microtubule dependency. Evidence for viral entry through caveolae was not obtained. These findings provide a fuller understanding of the early cell-entry events of the replication cycle for members of the genus Bocavirus.

  3. Trading Robustness Requirements in Mars Entry Trajectory Design (United States)

    Lafleur, Jarret M.


    One of the most important metrics characterizing an atmospheric entry trajectory in preliminary design is the size of its predicted landing ellipse. Often, requirements for this ellipse are set early in design and significantly influence both the expected scientific return from a particular mission and the cost of development. Requirements typically specify a certain probability level (6-level) for the prescribed ellipse, and frequently this latter requirement is taken at 36. However, searches for the justification of 36 as a robustness requirement suggest it is an empirical rule of thumb borrowed from non-aerospace fields. This paper presents an investigation into the sensitivity of trajectory performance to varying robustness (6-level) requirements. The treatment of robustness as a distinct objective is discussed, and an analysis framework is presented involving the manipulation of design variables to effect trades between performance and robustness objectives. The scenario for which this method is illustrated is the ballistic entry of an MSL-class Mars entry vehicle. Here, the design variable is entry flight path angle, and objectives are parachute deploy altitude performance and error ellipse robustness. Resulting plots show the sensitivities between these objectives and trends in the entry flight path angles required to design to these objectives. Relevance to the trajectory designer is discussed, as are potential steps for further development and use of this type of analysis.

  4. A Gestalt approach to Gram-negative entry. (United States)

    Silver, Lynn L


    A major obstacle confronting the discovery and development of new antibacterial agents to combat resistant Gram-negative (GN) organisms is the lack of a rational process for endowing compounds with properties that allow (or promote) entry into the bacterial cytoplasm. The major permeability difference between GN and Gram-positive (GP) bacteria is the GN outer membrane (OM) which is a permeability barrier itself and potentiates efflux pumps that expel compounds. Based on the fact that OM-permeable and efflux-deleted GNs are sensitive to many anti-GP drugs, recent efforts to approach the GN entry problem have focused on ways of avoiding efflux and transiting or compromising the OM, with the tacit assumption that this could allow entry of compounds into the GN cytoplasm. But bypassing the OM and efflux obstacles does not take into account the additional requirement of penetrating the cytoplasmic membrane (CM) whose sieving properties appear to be orthogonal to that of the OM. That is, tailoring compounds to transit the OM may well compromise their ability to enter the cytoplasm. Thus, a Gestalt approach to understanding the chemical requirements for GN entry seems a useful adjunct. This might consist of characterizing compounds which reach the cytoplasm, grouping (or binning) by routes of entry and formulating chemical 'rules' for those bins. This will require acquisition of data on large numbers of compounds, using non-activity-dependent methods of measuring accumulation in the cytoplasm. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Dopamine Receptor Activation Increases HIV Entry into Primary Human Macrophages (United States)

    Gaskill, Peter J.; Yano, Hideaki H.; Kalpana, Ganjam V.; Javitch, Jonathan A.; Berman, Joan W.


    Macrophages are the primary cell type infected with HIV in the central nervous system, and infection of these cells is a major component in the development of neuropathogenesis and HIV-associated neurocognitive disorders. Within the brains of drug abusers, macrophages are exposed to increased levels of dopamine, a neurotransmitter that mediates the addictive and reinforcing effects of drugs of abuse such as cocaine and methamphetamine. In this study we examined the effects of dopamine on HIV entry into primary human macrophages. Exposure to dopamine during infection increased the entry of R5 tropic HIV into macrophages, irrespective of the concentration of the viral inoculum. The entry pathway affected was CCR5 dependent, as antagonizing CCR5 with the small molecule inhibitor TAK779 completely blocked entry. The effect was dose-dependent and had a steep threshold, only occurring above 108 M dopamine. The dopamine-mediated increase in entry required dopamine receptor activation, as it was abrogated by the pan-dopamine receptor antagonist flupenthixol, and could be mediated through both subtypes of dopamine receptors. These findings indicate that the effects of dopamine on macrophages may have a significant impact on HIV pathogenesis. They also suggest that drug-induced increases in CNS dopamine may be a common mechanism by which drugs of abuse with distinct modes of action exacerbate neuroinflammation and contribute to HIV-associated neurocognitive disorders in infected drug abusers. PMID:25268786

  6. Structural and mechanistic studies of measles virus illuminate paramyxovirus entry.

    Directory of Open Access Journals (Sweden)

    Richard K Plemper


    Full Text Available Measles virus (MeV, a member of the paramyxovirus family of enveloped RNA viruses and one of the most infectious viral pathogens identified, accounts for major pediatric morbidity and mortality worldwide although coordinated efforts to achieve global measles control are in place. Target cell entry is mediated by two viral envelope glycoproteins, the attachment (H and fusion (F proteins, which form a complex that achieves merger of the envelope with target cell membranes. Despite continually expanding knowledge of the entry strategies employed by enveloped viruses, our molecular insight into the organization of functional paramyxovirus fusion complexes and the mechanisms by which the receptor binding by the attachment protein triggers the required conformational rearrangements of the fusion protein remain incomplete. Recently reported crystal structures of the MeV attachment protein in complex with its cellular receptors CD46 or SLAM and newly developed functional assays have now illuminated some of the fundamental principles that govern cell entry by this archetype member of the paramyxovirus family. Here, we review these advances in our molecular understanding of MeV entry in the context of diverse entry strategies employed by other members of the paramyxovirus family.

  7. BST2/Tetherin enhances entry of human cytomegalovirus.

    Directory of Open Access Journals (Sweden)

    Kasinath Viswanathan


    Full Text Available Interferon-induced BST2/Tetherin prevents budding of vpu-deficient HIV-1 by tethering mature viral particles to the plasma membrane. BST2 also inhibits release of other enveloped viruses including Ebola virus and Kaposi's sarcoma associated herpesvirus (KSHV, indicating that BST2 is a broadly acting antiviral host protein. Unexpectedly however, recovery of human cytomegalovirus (HCMV from supernatants of BST2-expressing human fibroblasts was increased rather than decreased. Furthermore, BST2 seemed to enhance viral entry into cells since more virion proteins were released into BST2-expressing cells and subsequent viral gene expression was elevated. A significant increase in viral entry was also observed upon induction of endogenous BST2 during differentiation of the pro-monocytic cell line THP-1. Moreover, treatment of primary human monocytes with siRNA to BST2 reduced HCMV infection, suggesting that BST2 facilitates entry of HCMV into cells expressing high levels of BST2 either constitutively or in response to exogenous stimuli. Since BST2 is present in HCMV particles we propose that HCMV entry is enhanced via a reverse-tethering mechanism with BST2 in the viral envelope interacting with BST2 in the target cell membrane. Our data suggest that HCMV not only counteracts the well-established function of BST2 as inhibitor of viral egress but also employs this anti-viral protein to gain entry into BST2-expressing hematopoietic cells, a process that might play a role in hematogenous dissemination of HCMV.

  8. Capstone projects as scholarship of application in entry-level occupational therapy education. (United States)

    Jirikowic, Tracy; Pitonyak, Jennifer S; Rollinger, Beth; Fogelberg, Donald; Mroz, Tracy M; Powell, Janet M


    Capstone projects are integrative student learning experiences used in higher education. This article describes the value and merit of capstone projects as scholarship of application within an entry-level occupational therapy education program. The capstone process is outlined and roles and responsibilities of student, faculty members, and community mentors described. Summative curricular evaluation from 5 years of capstone projects indicated that project characteristics and objectives aligned with the theory and desired outcomes of applied scholarship in the areas of student learning, faculty practice and development, and community service. Challenges identified can further inform development of the capstone experience in occupational therapy education.

  9. Mineralogical alteration of artificial meteorites during atmospheric entry. The STONE-5 experiment (United States)

    Brandstätter, Franz; Brack, André; Baglioni, Pietro; Cockell, Charles S.; Demets, René; Edwards, Howell G. M.; Kurat, Gero; Osinski, Gordon R.; Pillinger, Judith M.; Roten, Claude-Alain; Sancisi-Frey, Suzy


    The generic concept of the artificial meteorite experiment STONE is to fix rock samples bearing microorganisms on the heat shield of a recoverable space capsule and to study their modifications during atmospheric re-entry. The STONE-5 experiment was performed mainly to answer astrobiological questions. The rock samples mounted on the heat shield were used (i) as a carrier for microorganisms and (ii) as internal control to verify whether physical conditions during atmospheric re-entry were comparable to those experienced by "real" meteorites. Samples of dolerite (an igneous rock), sandstone (a sedimentary rock), and gneiss impactite from Haughton Crater carrying endolithic cyanobacteria were fixed to the heat shield of the unmanned recoverable capsule FOTON-M2. Holes drilled on the back side of each rock sample were loaded with bacterial and fungal spores and with dried vegetative cryptoendoliths. The front of the gneissic sample was also soaked with cryptoendoliths. The mineralogical differences between pre- and post-flight samples are detailed. Despite intense ablation resulting in deeply eroded samples, all rocks in part survived atmospheric re-entry. Temperatures attained during re-entry were high enough to melt dolerite, silica, and the gneiss impactite sample. The formation of fusion crusts in STONE-5 was a real novelty and strengthens the link with real meteorites. The exposed part of the dolerite is covered by a fusion crust consisting of silicate glass formed from the rock sample with an admixture of holder material (silica). Compositionally, the fusion crust varies from silica-rich areas (undissolved silica fibres of the holder material) to areas whose composition is "basaltic". Likewise, the fusion crust on the exposed gneiss surface was formed from gneiss with an admixture of holder material. The corresponding composition of the fusion crust varies from silica-rich areas to areas with "gneiss" composition (main component potassium-rich feldspar). The

  10. Reliable and efficient injury assessment for free-fall lifeboat occupants during water entry: Correlation study between lifeboat acceleration indicators and simulated human injury responses

    NARCIS (Netherlands)

    Dam, E. van; Uittenbogaard, J.; Reinholdtsen, S.A.; Fouques, S.; Sauder, T.


    The evacuation of personnel from an offshore installation in severe weather conditions is generally ensured by free-fall lifeboats. During the water entry phase of the launch, the lifeboat may be subject to large acceleration loads that may cause harmful acceleration-induced loads on the occupants.

  11. The method of adaptation under the parameters of the subject of the information interaction

    Directory of Open Access Journals (Sweden)

    Инесса Анатольевна Воробьёва


    Full Text Available To ensure the effectiveness of settings (adaptation created software and hardware on the particular subject of the method was developed for adaptation under the parameters of the subject of information interaction in the form of a set of operations to build a network dialog procedures on the basis of accounting for entry-level qualification of the subject, assessment of the current level of skills and operational restructuring of the network in accordance with the assessment of his level.

  12. Estimating Subjective Probabilities

    DEFF Research Database (Denmark)

    Andersen, Steffen; Fountain, John; Harrison, Glenn W.

    Subjective probabilities play a central role in many economic decisions, and act as an immediate confound of inferences about behavior, unless controlled for. Several procedures to recover subjective probabilities have been proposed, but in order to recover the correct latent probability one must...

  13. Estimating Subjective Probabilities

    DEFF Research Database (Denmark)

    Andersen, Steffen; Fountain, John; Harrison, Glenn W.


    Subjective probabilities play a central role in many economic decisions and act as an immediate confound of inferences about behavior, unless controlled for. Several procedures to recover subjective probabilities have been proposed, but in order to recover the correct latent probability one must ...

  14. Subjective meaning: an introduction

    NARCIS (Netherlands)

    van Wijnbergen-Huitink, Janneke; van Wijbergen-Huitink, Janneke; Meier, Cécile

    This introductory chapter traces some of the considerations on the basis of which relativistic approaches to subjective meaning became en vogue. In doing so, the chapter provides an overview of the relevant linguistic and philosophical issues when developing a treatment of subjectivity. In addition,

  15. Subjective safety in traffic.

    NARCIS (Netherlands)


    The term ‘subjective safety in traffic’ refers to people feeling unsafe in traffic or, more generally, to anxiety regarding being unsafe in traffic for oneself and/or others. Subjective safety in traffic can lead to road users limiting their mobility and social activities, which is one of the

  16. Subjective poverty line definitions

    NARCIS (Netherlands)

    J. Flik; B.M.S. van Praag (Bernard)


    textabstractIn this paper we will deal with definitions of subjective poverty lines. To measure a poverty threshold value in terms of household income, which separates the poor from the non-poor, we take into account the opinions of all people in society. Three subjective methods will be discussed

  17. Control Areas (United States)

    Department of Homeland Security — This feature class represents electric power Control Areas. Control Areas, also known as Balancing Authority Areas, are controlled by Balancing Authorities, who are...

  18. Mars Entry Atmospheric Data System Modeling, Calibration, and Error Analysis (United States)

    Karlgaard, Christopher D.; VanNorman, John; Siemers, Paul M.; Schoenenberger, Mark; Munk, Michelle M.


    The Mars Science Laboratory (MSL) Entry, Descent, and Landing Instrumentation (MEDLI)/Mars Entry Atmospheric Data System (MEADS) project installed seven pressure ports through the MSL Phenolic Impregnated Carbon Ablator (PICA) heatshield to measure heatshield surface pressures during entry. These measured surface pressures are used to generate estimates of atmospheric quantities based on modeled surface pressure distributions. In particular, the quantities to be estimated from the MEADS pressure measurements include the dynamic pressure, angle of attack, and angle of sideslip. This report describes the calibration of the pressure transducers utilized to reconstruct the atmospheric data and associated uncertainty models, pressure modeling and uncertainty analysis, and system performance results. The results indicate that the MEADS pressure measurement system hardware meets the project requirements.

  19. Features of Human Herpesvirus-6A and -6B Entry

    Directory of Open Access Journals (Sweden)

    Takahiro Maeki


    Full Text Available Human herpesvirus-6 (HHV-6 is a T lymphotropic herpesvirus belonging to the Betaherpesvirinae subfamily. HHV-6 was long classified into variants A and B (HHV-6A and HHV-6B; however, recently, HHV-6A and HHV-6B were reclassified as different species. The process of herpesvirus entry into target cells is complicated, and in the case of HHV-6A and HHV-6B, the detailed mechanism remains to be elucidated, although both viruses are known to enter cells via endocytosis. In this paper, (1 findings about the cellular receptor and its ligand for HHV-6A and HHV-6B are summarized, and (2 a schematic model of HHV-6A’s replication cycle, including its entry, is presented. In addition, (3 reports showing the importance of lipids in both the HHV-6A envelope and target-cell membrane for viral entry are reviewed, and (4 glycoproteins involved in cell fusion are discussed.

  20. Confined space entry program for the Westinghouse Hanford Company

    Energy Technology Data Exchange (ETDEWEB)

    Cornell, T.M.


    To comply with anticipated OSHA regulatory requirements concerning Permit-Required Confined Spaces, Westinghouse Hanford Company (WHC) created a Confined Spaces Task Team. The primary focus of the task team was to prepare a formal Confined Space Entry (CSE) Program that would ensure full compliance with the anticipated OSHA requirements. A comprehensive training plan was also prepared and submitted for approval as soon as the new CSE Program was approved and released for implementation. On January 14, 1993, OSHA released their final ruling which contained several further changes, requiring the WHC Confined Space Entry Program and Training Plan to be revised. The revised training manual and lessons learned in establishing a Confined Space Entry Program are presented.

  1. Paramyxovirus Fusion and Entry: Multiple Paths to a Common End (United States)

    Chang, Andres; Dutch, Rebecca E.


    The paramyxovirus family contains many common human pathogenic viruses, including measles, mumps, the parainfluenza viruses, respiratory syncytial virus, human metapneumovirus, and the zoonotic henipaviruses, Hendra and Nipah. While the expression of a type 1 fusion protein and a type 2 attachment protein is common to all paramyxoviruses, there is considerable variation in viral attachment, the activation and triggering of the fusion protein, and the process of viral entry. In this review, we discuss recent advances in the understanding of paramyxovirus F protein-mediated membrane fusion, an essential process in viral infectivity. We also review the role of the other surface glycoproteins in receptor binding and viral entry, and the implications for viral infection. Throughout, we concentrate on the commonalities and differences in fusion triggering and viral entry among the members of the family. Finally, we highlight key unanswered questions and how further studies can identify novel targets for the development of therapeutic treatments against these human pathogens. PMID:22590688

  2. Paramyxovirus Fusion and Entry: Multiple Paths to a Common End

    Directory of Open Access Journals (Sweden)

    Rebecca E. Dutch


    Full Text Available The paramyxovirus family contains many common human pathogenic viruses, including measles, mumps, the parainfluenza viruses, respiratory syncytial virus, human metapneumovirus, and the zoonotic henipaviruses, Hendra and Nipah. While the expression of a type 1 fusion protein and a type 2 attachment protein is common to all paramyxoviruses, there is considerable variation in viral attachment, the activation and triggering of the fusion protein, and the process of viral entry. In this review, we discuss recent advances in the understanding of paramyxovirus F protein-mediated membrane fusion, an essential process in viral infectivity. We also review the role of the other surface glycoproteins in receptor binding and viral entry, and the implications for viral infection. Throughout, we concentrate on the commonalities and differences in fusion triggering and viral entry among the members of the family. Finally, we highlight key unanswered questions and how further studies can identify novel targets for the development of therapeutic treatments against these human pathogens.

  3. Disambiguating bilingual nominal entries against WordNet

    CERN Document Server

    Rigau, G; Rigau, German; Agirre, Eneko


    This paper explores the acquisition of conceptual knowledge from bilingual dictionaries (French/English, Spanish/English and English/Spanish) using a pre-existing broad coverage Lexical Knowledge Base (LKB) WordNet. Bilingual nominal entries are disambiguated agains WordNet, therefore linking the bilingual dictionaries to WordNet yielding a multilingual LKB (MLKB). The resulting MLKB has the same structure as WordNet, but some nodes are attached additionally to disambiguated vocabulary of other languages. Two different, complementary approaches are explored. In one of the approaches each entry of the dictionary is taken in turn, exploiting the information in the entry itself. The inferential capability for disambiguating the translation is given by Semantic Density over WordNet. In the other approach, the bilingual dictionary was merged with WordNet, exploiting mainly synonymy relations. Each of the approaches was used in a different dictionary. Both approaches attain high levels of precision on their own, sh...

  4. Clinical nurse specialist leadership in computerized provider order entry design. (United States)

    Roggow, Darla J; Solie, Carol J; Tracy, Mary Fran; Gjere, Niki


    The purpose of this clinical project was to design and implement a computerized provider order entry system. Well-designed clinical computer systems can advance best practice and quality decision making, leading to improvements in patient and organizational outcomes. An Orders Design Group composed of clinical nurse specialists (CNSs), staff nurses, and information management personnel was formed. CNSs used competencies in the system sphere to lead the integration of the needs of patients, nurses, and organizations into new technologies. CNSs facilitated implementation of a collaboratively designed interdisciplinary computerized order entry process. Evaluation of the design and implementation process demonstrated greater success with the order entry system under the leadership of CNSs than past initiatives where CNSs were not in leadership roles. CNS competencies in designing and implementing innovative system-level solutions are key to clinical information systems design.

  5. Towards a Market Entry Framework for Digital Payment Platforms

    DEFF Research Database (Denmark)

    Kazan, Erol; Damsgaard, Jan


    This study presents a framework to understand and explain the design and configuration of digital payment platforms and how these platforms create conditions for market entries. By embracing the theoretical lens of platform envelopment, we employed a multiple and comparative-case study...... in a European setting by using our framework as an analytical lens to assess market-entry conditions. We found that digital payment platforms have acquired market entry capabilities, which is achieved through strategic platform design (i.e., platform development and service distribution) and technology design...... (i.e., issuing evolutionary and revolutionary payment instruments). The studied cases reveal that digital platforms leverage payment services as a mean to bridge and converge core and adjacent platform markets. In so doing, platform envelopment strengthens firms’ market position in their respective...

  6. Mars Atmospheric Entry Integrated Navigation with Partial Intermittent Measurements

    Directory of Open Access Journals (Sweden)

    Tai-shan Lou


    Full Text Available Signal degradation suffered by the vehicle is a combination brownout and blackout during Mars atmospheric entry. The communications brownout means that signal fades and blackout means that the signal is lost completely. The communications brownout and blackout periods are analyzed and predicted with an altitude and velocity profiles. In the brownout period, the range measurements between the vehicle and the orbiters are modeled as intermittent measurements with the radio signal arrival probabilities, which are distributed as a Rayleigh distribution of the electron number density around the entry vehicle. A new integrated navigation strategy during the Mars atmospheric entry phase is proposed to consider the probabilities of the radio measurements in the communications brownout and blackout periods under the IMU/beacon scenario based on the information filter with intermittent measurements. Numerical navigation simulations are designed to show the performance of the proposed navigation strategy under the integrated navigation scenario.

  7. Energy Data Base: Subject Thesaurus permutated listing. Revision 6, Appendix

    Energy Technology Data Exchange (ETDEWEB)

    Redford, J.S. (ed.)


    The Office of Scientific and Technical Information, in its role of managing scientific and technical information in support of DOE programs, develops and maintains a standardized vocabulary for indexing this information. This permutated listing, an appendix to the Energy Data Base: Subject Thesaurus (DOE/TIC-7000-R6), has been prepared to alleviate the problems of entry to a large multidisciplinary thesaurus containing both single and multiword descriptors. It is designed to be used in conjunction with the Subject Thesaurus and is not to be used alone.

  8. Operational Area Environmental Evaluations

    Energy Technology Data Exchange (ETDEWEB)

    Bailey-White, Brenda Eileen [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Nagy, Michael David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Wagner, Katrina Marie [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Goodman, Thomas Richard [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Herring, Allen [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Catechis, Christopher S. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Kinghorn, Aubrianna Nicole [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Johnson, Ellie [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Barthel, Michael David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Casaus, Benito [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)


    The Operational Area Environmental Evaluation update provides a description of activities that have the potential to adversely affect natural and cultural resources, including soil, air, water, biological, ecological, and historical resources. The environmental sensitivity of an area is evaluated and summarized, which may facilitate informed management decisions as to where development may be prohibited, restricted, or subject to additional requirements.

  9. The role of digital data entry in participatory environmental monitoring. (United States)

    Brammer, Jeremy R; Brunet, Nicolas D; Burton, A Cole; Cuerrier, Alain; Danielsen, Finn; Dewan, Kanwaljeet; Herrmann, Thora Martina; Jackson, Micha V; Kennett, Rod; Larocque, Guillaume; Mulrennan, Monica; Pratihast, Arun Kumar; Saint-Arnaud, Marie; Scott, Colin; Humphries, Murray M


    Many argue that monitoring conducted exclusively by scientists is insufficient to address ongoing environmental challenges. One solution entails the use of mobile digital devices in participatory monitoring (PM) programs. But how digital data entry affects programs with varying levels of stakeholder participation, from nonscientists collecting field data to nonscientists administering every step of a monitoring program, remains unclear. We reviewed the successes, in terms of management interventions and sustainability, of 107 monitoring programs described in the literature (hereafter programs) and compared these with case studies from our PM experiences in Australia, Canada, Ethiopia, Ghana, Greenland, and Vietnam (hereafter cases). Our literature review showed that participatory programs were less likely to use digital devices, and 2 of our 3 more participatory cases were also slow to adopt digital data entry. Programs that were participatory and used digital devices were more likely to report management actions, which was consistent with cases in Ethiopia, Greenland, and Australia. Programs engaging volunteers were more frequently reported as ongoing, but those involving digital data entry were less often sustained when data collectors were volunteers. For the Vietnamese and Canadian cases, sustainability was undermined by a mismatch in stakeholder objectives. In the Ghanaian case, complex field protocols diminished monitoring sustainability. Innovative technologies attract interest, but the foundation of effective participatory adaptive monitoring depends more on collaboratively defined questions, objectives, conceptual models, and monitoring approaches. When this foundation is built through effective partnerships, digital data entry can enable the collection of more data of higher quality. Without this foundation, or when implemented ineffectively or unnecessarily, digital data entry can be an additional expense that distracts from core monitoring objectives

  10. Journal entries facilitating preprofessional scientific literacy and mutualistic symbiotic relationships (United States)

    Vander Vliet, Valerie J.

    This study explored journal writing as an alternative assessment to promote the development of pre-professional scientific literacy and mutualistic symbiotic relationships between teaching and learning, instruction and assessment, and students and teachers. The larger context of this study is an action reaction project of the attempted transformation of a traditional first year undergraduate pre-professional biology class to sociocultural constructivist principles. The participants were commuter and residential, full and part-time students ranging in age from 18 to 27 and 18/21 were female. The backgrounds of the students varied considerably, ranging from low to upper middle income, including students of Black and Asian heritage. The setting was a medium-sized Midwestern university. The instructor has twenty years of experience teaching Biology at the college level. The data were analyzed using the constant comparative method and the development of grounded theory. The journal entries were analyzed as to their function and form in relationship to the development of multiple aspects of pre-professional scientific literacy. The perceptions of the students as to the significance of the use of journal entries were also determined through the analysis of their use of journal entries in their portfolios and statements in surveys and portfolios. The analysis revealed that journal entries promoted multiple aspects of pre-professional scientific literacy in both students and the instructor and facilitated the development of mutualistic symbiotic relationships between teaching and learning, instruction and assessment, and students and teachers. The function analysis revealed that the journal entries fulfilled the functions intended for the development of multiple aspects of pre-professional scientific literacy. The complexity of journal writing emerged from the form analysis, which revealed the multiple form elements inherent in journal entries. Students perceived journal

  11. Minimum wages as a barrier to entry: Evidence from Germany


    Bachmann, Ronald; Bauer, Thomas K.; Kröger, Hanna


    This study analyses employers' support for the introduction of industry-specific minimum wages as a cost-raising strategy in order to deter market entry. Using a unique data set consisting of 800 firms in the German service sector, we find some evidence that high-productivity employers support minimum wages. We further show that minimum wage support is higher in industries and regions with low barriers to entry. This is particularly the case in East Germany, where the perceived threat of low-...

  12. Best Entry Points for Structured Document Retrieval - Part I: Characteristics

    DEFF Research Database (Denmark)

    Reid, Jane; Lalmas, Mounia; Finesilver, Karen


    Structured document retrieval makes use of document components as the basis of the retrieval process, rather than complete documents. The inherent relationships between these components make it vital to support users' natural browsing behaviour in order to offer effective and efficient access...... to structured documents. This paper examines the concept of best entry points, which are document components from which the user can browse to obtain optimal access to relevant document components. In particular this paper investigates the basic characteristics of best entry points....

  13. Partial Acquistion as an Entry Mode in Transition Economies

    DEFF Research Database (Denmark)

    Jakobsen, Kristian; Meyer, Klaus E.


    Multinational enterprises often acquire stakes in an existing enterprise when entering emerging economies. This paper examines the determinants of entry mode choices with a special focus on these partial acquisitions, which have received little attention in the scholarly literature. We show...... that partial acquisitions have features that are distinct from other modes with respect to the transfer of resources to the subsidiary and the determinants of entry mode choice. Recent research suggests that a buyer prefers partial acquisitions, when a seller possesses asymmetric information advantages...

  14. Unifying Subjectivity and Objectivity

    Directory of Open Access Journals (Sweden)

    Murugesan Chandrasekaran


    Full Text Available The contribution of modern science to the progress of civilization is immeasurable. Even its tendency toward exclusive concentration on the objective world has had salutary effects of great value. Modern science has wiped away much that was merely superstitious or speculative. Its rejection of unfounded opinions and prejudices has helped the thinking mind question conventional beliefs, shed preferences and prejudices, and challenge established authority. But modern systems thinking inherited from natural science is the suppression of the subjective dimension of reality. Many complex systems are an attempt to define and represent all subjective experience in physical terms. The modern man has a bias towards objectivity. The powerful influence of sense impressions on his mind and thinking makes him ignore the subjective experience and consider only objective facts as a valid, legitimate and representation of reality. Observing objective factors that are physical is easier than observing subjective factors that are subtle. The mechanistic view of reality has led to the rejection of the role of the individual in social development as insignificant. The individuals determine the development of society. Their social power has its roots both in subjective factors and objective factors. Economy, politics, society, and culture are inseparable dimensions of a single integrated reality. Subject and object constitute an integrated whole. The mind sees them as separate and independent. Or it views one as completely subordinate to the other. Unbiased approach to the study of all human experiences may prove that subject and object are interdependent dimensions or elements of reality.


    Directory of Open Access Journals (Sweden)

    D.N. Bakhrakh


    Full Text Available The question about the subjects of law branches is concerning the number of most important and difficult in law science. Its right decision influences on the subject of law regulation, precise definition of addressees of law norms, the volume of their rights and duties, the limits of action of norms of Main part of the branch, its principles. Scientific investigations, dedicated to law subjects system, promote the development of recommendations for the legislative and law applying activity; they are needed for scientific work organization and student training, for preparing qualified lawyers.

  16. Airborne re-entry observation experiment SLIT: UV spectroscopy during STARDUST and ATV1 re-entry (United States)

    Löhle, Stefan; Wernitz, Ricarda; Herdrich, Georg; Fertig, Markus; Röser, Hans-Peter; Ritter, Heiko


    Emission spectra during re-entry have been measured in 2006 for the STARDUST capsule and in 2008 for the ATV1 "Jules Verne" re-entry. This paper summarizes the approach to design the airborne UV spectroscopic setup and its modifications with respect to the missions. For the STARDUST mission, results of data analysis of data presented in 2008 are given while for the ATV1 observation first spectra of the main disruption are exemplary presented. The surface radiation during the STARDUST re-entry is used to estimate convective and radiative heat flux using different analytical models. A first look at the spectroscopic footprint of ATV1 shows that during the first explosive event, a severe break-up of the main ATV1 structure occurs. However, a correlation with an explosion of fuel could not be observed.

  17. Florida Master Teacher Program: Testing Teacher Subject Matter Knowledge. (United States)

    Lavely, Carolyn; And Others


    The efforts of the Florida Institute for Instructional Research and Practice in designing, developing, and analyzing the subject area knowledge tests of the Florida Master Teacher Program are described. A total of 13 subject area examinations was developed in 1984-85, and 5 additional tests were developed the following year. For each subject area…

  18. Energy Data Base: Subject Thesaurus

    Energy Technology Data Exchange (ETDEWEB)

    Raridon, M.H. (ed.)


    This seventh edition of the subject thesaurus contains the standard vocabulary of indexing terms (descriptors) developed and structured by the technical staff of the Office of Scientific and Technical Information as part of its subject indexing activities for building and maintaining the Energy Data Base (EDB) and other energy information data bases for the Department of Energy (DOE). The purpose of this thesaurus is to enhance the efficiency of information retrieval from these data bases. This structured vocabulary reflects the scope of DOE's research, development, and technological programs and encompasses terminology derived not only from the basic sciences for also from areas of energy resources, conservation, safety, environmental impact, and regulation. There are 21,080 valid descriptors and 5683 forbidden terms in this edition of the Thesaurus. These descriptors are listed alphabetically.

  19. Public Relations: Roles, Entry Requirements and Professionalism

    Directory of Open Access Journals (Sweden)

    Kadek Dwi Cahaya Putra


    Full Text Available Abstract: This paper attempts to describe that there is a chance for non-Public Relations graduates to work as or at the Public Relations industry. Studies have shown that Public Relations practitioners are mostly from generalist background (not Public Relations and even come into the job by chance. A Public Relations is a very sociable person, possess a mix of functional, managerial and negotiating abilities as well as analytical and well-developed communication and understand people and human psychology. With working roles of Expert Prescriber, Communication Facilitator, Problem Solving Facilitator and Communication Technician, a Public Relations needs to be well prepared by learning foreign language, joining personality improvement course, developing networking and understanding computer and communication technology. Areas of where a Public relations works are in-house (organization/company, consultancy and freelance practitioner having various titles showing their main function in the organization such as public affairs, event manager, community relations manager, marketing communication executive, employee relations manager, corporate communications manager, media coordinator. As there is an increased challenge of Public Relations’s professionalism, a true practitioner is best prepared by educational institutions with lecturers having sound education and practice combined with extensive link-and -match research and industrial-practical placement for the graduates.


    Directory of Open Access Journals (Sweden)

    Petar Protić


    Full Text Available High school and academic libraries users need precise classifi cation and subject access review of printed and electronic resources. In library catalogue since, Universal Decimal Classifi cation (UDC -similar to Dewey system - ex classifi es research and scientifi c areas. in subject areas of 796 Sport and 371 Teaching. Nowadays, users need structure of subjects by disciplines in science. Full-open resources of library must be set for users in subject access catalogue, because on the example of bachelors degree thesis in Faculty of Physical Education in Novi Sad they reaches for disciplines in database with 36 indexes sort by fi rst letters in names (Athletics, Boxing, Cycling, etc. This database have single and multiplied index for each thesis. Users in 80% cases of research according to the subject access catalogue of this library.

  1. The Data Subject

    DEFF Research Database (Denmark)

    Blume, Peter


    This article considers whether it is fortunate that data protection rules, as a starting point, apply to all physical persons as data subjects, or whether it would be better to differentiate between kinds of persons on grounds of their ability to act as a data subject. In order to protect all...... persons, it is argued that a principle of care should be part of data protection law....

  2. Protein/peptide-based entry/fusion inhibitors as anti-HIV therapies: challenges and future direction. (United States)

    Fumakia, Miral; Yang, Sidi; Gu, Jijin; Ho, Emmanuel A


    The failures of several first-generation and second-generation small molecule drug-based anti-HIV therapies in various stages of clinical trials are an indication that there is a need for a paradigm shift in the future designs of anti-HIV therapeutics. Over the past several decades, various anti-HIV drugs have been developed, among them, protein/peptide-based therapies. From the first peptide discovered (SJ2176) to the first peptide approved by the Food and Drug Administration (DP178/T20/enfuvirtide/Fuzeon®), anti-HIV proteins/peptides as fusion/entry inhibitors have been shown to provide potent effects and benefits. This review summarizes the past and current endeavors in this area, discusses the potential mechanisms of action for various anti-HIV proteins/peptides, compares the advantages and disadvantages between the different proteins/peptides, and finally, examines the future direction of the field, specifically, strategies that will enhance the therapeutic efficacy of fusion/entry inhibitor-based anti-HIV proteins/peptides. Although there are numerous reviews highlighting the general field of entry/fusion inhibitors, there is a lack of literature focused on protein/peptide-based entry/fusion inhibitors for HIV therapy, and as a result, this review is intended to fill this void by summarizing the past, current, and future development of these macromolecules. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

  3. A Study of Nutrition in Entry-Level Dental Hygiene Education Programs. (United States)

    Johnson, Deborah L; Gurenlian, JoAnn R; Freudenthal, Jacqueline J


    The aims of this study were to document the extent of nutritional content in U.S. dental hygiene program curricula; identify program directors' opinions, perceptions, and barriers to expanding nutritional content; and evaluate if a proposed nutrition curriculum model would be beneficial. This mixed methods study involved quantitative and qualitative aspects. An invitation letter was sent to all 335 directors of entry-level U.S. dental hygiene programs. In response, 55 directors submitted nutrition course syllabi from their programs (16.4% of the total) for the quantitative analysis. In addition, 14 nutrition instructors and ten program directors were interviewed regarding their perceptions and opinions of nutrition education for dental hygiene students. All aspects of the content analysis results revealed that nutrition content in entry-level dental hygiene programs is diverse. Some programs did not include nutrition content, while others provided oral and systemic nutrition intervention subject matter. Some programs offered multiple clinical nutrition applications and patient contact opportunities while most required none. The interview results disclosed a variety of opinions and perceptions of dental hygienists' role in nutrition. Several interviewees viewed dental hygienists' role in nutrition to be an integral part of patient care, while others indicated no role or providing caries prevention counseling only. Although dental hygienists are expected to provide nutrition assessments and interventions, no standards or standardized competencies exist for nutrition in dental hygiene education. A standardized nutrition model could be beneficial for entry-level programs to ensure dental hygienists possess basic knowledge to perform nutrition assessments and intervention to address Healthy People 2020's intervention initiatives.

  4. Repetitive natriuresis and blood pressure. Long-term calcium entry blockade with isradipine. (United States)

    Krusell, L R; Jespersen, L T; Schmitz, A; Thomsen, K; Pedersen, O L


    The long-term effects (3.5 months) of a new calcium entry blocker of the 1-4-dihydropyridine class, isradipine (PN 200-110), on renal hemodynamics and excretional parameters were investigated in 10 essential hypertensive subjects (World Health Organization Classes I and II). Blood pressure and renal vascular resistance fell significantly (p less than 0.001), and a slight increase in glomerular filtration rate and renal plasma flow was seen (p less than 0.05). Output of fluid from the proximal tubules, measured as clearance of lithium and uric acid, increased significantly (p less than 0.01 and p less than 0.05, respectively), and a compensatory increase in absolute reabsorption of sodium beyond the proximal tubular level accompanied by an increase in clearance of potassium was noted. A 40% increase in the resultant clearance of sodium (p less than 0.01) and an increase in diuresis (p less than 0.05) followed the morning dose of isradipine after 3.5 months of treatment. Changes in blood pressure were significantly correlated with changes in absolute proximal reabsorption of sodium (r = 0.81), excretion of sodium (r = -0.64), and diuresis (r = -0.80). Thus, the natriuretic properties of calcium entry blockers may be more important for the long-term antihypertensive effect than the vasodilator effect per se. A model for renal sodium handling following treatment with calcium entry blockers was proposed. Although a causal relationship is not implied, isradipine induced a sustained, repetitive postdose effect on proximal fluid output, net natriuresis, and diuresis, that was intimately related to the long-term blood pressure-regulating response.

  5. 7 CFR 322.21 - Post-entry handling. (United States)


    ... Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE... or parasites of bees, or of undesirable species or strains of honeybees. We will use the following... systems, contain the restricted organisms, parasites and pathogens, and prevent the entry of other...

  6. Parachute triggering algorithms for re-entry vehicles

    NARCIS (Netherlands)

    Ording, B.E.; Sudars, M.; Brouwer, G.F.

    Most re-entry vehicles utilize a Descent and Landing System (DLS) for a safe descent through the lowest part of the atmosphere. It usually requires deployment in a certain suitable range of flight conditions, which has to be estimated by limited means of navigation. This paper presents a comparison

  7. 76 FR 13703 - New Origin Entry Separation & Containerization Standards (United States)


    ...'' information in L604 or L603. There is no minimum load threshold for this separation. Periodicals Local Surface... for Periodicals piece processing based on the origin entry point. Prepare container (pallet) placards... a container price applicable to Periodicals bundles placed directly on mixed ADC pallets or...

  8. The role of digital data entry in participatory environmental monitoring

    NARCIS (Netherlands)

    Brammer, Jeremy R.; Brunet, Nicolas D.; Burton, A.C.; Cuerrier, Alain; Danielsen, Finn; Dewan, Kanwaljeet; Herrmann, Thora Martina; Jackson, Micha V.; Kennett, Rod; Larocque, Guillaume; Mulrennan, Monica; Pratihast, Arun Kumar; Saint-Arnaud, Marie; Scott, Colin; Humphries, Murray M.


    Many argue that monitoring conducted exclusively by scientists is insufficient to address ongoing environmental challenges. One solution entails the use of mobile digital devices in participatory monitoring (PM) programs. But how digital data entry affects programs with varying levels of

  9. Motivational interview improves treatment entry in homeless veterans. (United States)

    Wain, R Morgan; Wilbourne, Paula L; Harris, Keith W; Pierson, Heather; Teleki, Jasmine; Burling, Thomas A; Lovett, Steven


    Motivational Interviewing (MI) has successfully been used to facilitate entry and compliance in drug and alcohol treatment programs. Some questions have been raised as to the effectiveness of MI in severely distressed populations. This study aims to assess the effectiveness of MI in a population of homeless, unemployed, and substance dependent veterans who are being wait-listed for entry into a residential treatment program. Seventy-five veterans placed on a wait-list were randomized to receive a single MI or standard (Std) intake interview. Outcomes assessed were entry, and length of stay (LOS). Secondary outcomes assessed included program completion and rates of graduation. Readiness to change and self-efficacy were assessed before and after the interview. Significantly more participants entered the program in the MI group (95%) than in the Std group (71%). Although those in the MI group remained in the program longer, and had higher program completion and graduation rates, these differences were not statistically significant. No significant between-group or within-group differences were found in readiness or self-efficacy. This study demonstrates that a single, easily administered intervention can increase program entry. Also based on the study findings, further research into the question of whether MI can increase program retention, in a severely distressed population, is warranted. Published by Elsevier Ireland Ltd.

  10. 77 FR 5681 - Establishment of Global Entry Program (United States)


    ... entry and exit at Amsterdam Airport Schiphol. It uses iris scans to provide quick and secure biometric... to conduct the biometric based background checks and participate in an interview at an enrollment... personally identifiable information (PII), including biometric data and employment history, in GES may be...

  11. 7 CFR 322.11 - Ports of entry. (United States)


    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Ports of entry. 322.11 Section 322.11 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Adult...

  12. 7 CFR 322.19 - Inspection; refusal of entry. (United States)


    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Inspection; refusal of entry. 322.19 Section 322.19 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of...

  13. 7 CFR 322.35 - Ports of entry. (United States)


    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Ports of entry. 322.35 Section 322.35 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and Transit of...

  14. 7 CFR 322.10 - Inspection; refusal of entry. (United States)


    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Inspection; refusal of entry. 322.10 Section 322.10 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of...

  15. 7 CFR 322.20 - Ports of entry. (United States)


    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Ports of entry. 322.20 Section 322.20 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation of Restricted...

  16. 7 CFR 322.34 - Inspection; refusal of entry. (United States)


    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Inspection; refusal of entry. 322.34 Section 322.34 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND BEEKEEPING EQUIPMENT Importation and...

  17. 50 CFR 660.512 - Limited entry fishery. (United States)


    ... of a vessel with more than 5 mt of CPS finfish on board in the CPS Limited Entry Zone, other than... permit for a vessel will be issued only if that vessel landed 100 mt of CPS finfish from January 1, 1993...) and implementing regulations at 15 CFR part 904, subpart D, apply. (f) Initial issuance. (1) The SFD...

  18. The Association of Kindergarten Entry Age with Early Literacy Outcomes (United States)

    Huang, Francis L.; Invernizzi, Marcia A.


    The authors investigated whether age at kindergarten entry was associated with early literacy achievement gaps and if these gaps persisted over time. Using the kindergarten age eligibility cutoff date, they created 2 groups of students who represented the oldest and youngest children in a cohort of students in high-poverty, low-performing schools.…

  19. 9 CFR 93.806 - Animals refused entry. (United States)


    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Animals refused entry. 93.806 Section 93.806 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS IMPORTATION OF...

  20. Handling Qualities of a Capsule Spacecraft During Atmospheric Entry (United States)

    Bilimoria, Karl D.; Mueller, Eric R.


    A piloted simulation was conducted to study handling qualities for capsule spacecraft entering the Earth s atmosphere. Eight evaluation pilots, including six pilot astronauts, provided Cooper-Harper ratings, workload ratings, and qualitative comments. The simulation began after descending through the atmospheric entry interface point and continued until the drogue parachutes deployed. There were two categories of piloting tasks, both of which required bank angle control. In one task category, the pilot followed a closed-loop bank angle command computed by the backup guidance system to manage g-loads during entry. In the other task category, the pilot used intuitive rules to determine the desired bank angle independently, based on an open-loop schedule of vertical speed, Mach, and total energy specified at several range-to-target gates along the entry trajectory. Pilots were able to accurately track the bank angle guidance commands and steered the capsule toward the recovery site with essentially the same range error as the benchmark autopilot trajectory albeit with substantially higher propellant usage, and the handling qualities for this task were satisfactory. Another key result was that the complex piloting task of atmospheric entry could be performed satisfactorily, even in the presence of large dispersions, by controlling bank angle to follow a simple open-loop schedule.

  1. Mentor Relationships for Entry-Level Men in Student Affairs (United States)

    Calhoun, Daniel W.; Taub, Deborah J.


    This qualitative study examined the experiences of entry-level men in student affairs, with particular focus on the function of mentors and role models. Through semistructured interviews and a focus group, 22 participants shared their thoughts and experiences regarding mentorship. Results indicated mentorship to be instrumental in recruitment and…

  2. Forecast and capacity planning for Nogales' ports of entry. (United States)


    This report documents the findings and the activities performed under ADOT grant JPA 08024T. The overall purpose of this study was to forecast the number of border crossings by mode of traffic at the NogalesMariposa and DeConcini Ports of Entry...

  3. Methods and Devices: An Alternative Instrument for Making Entry ...

    African Journals Online (AJOL)

    Femoral shaft fractures are common in children and are increasingly being treated with elastic intramedullary nail. We outline an instrument we have used successfully to make an entry point for placement of elastic nail. Keywords: Elastic nailing, Fracture shaft femur, Technique ...

  4. Leadership: Industry Needs for Entry-Level Engineering Positions (United States)

    Hartmann, Beth Lin; Jahren, Charles T.


    This paper presents the results of a study that sought to identify what companies mean by the word "leadership" when used a job descriptions for entry-level, full-time engineering positions. Seven years of job posting data was analyzed to first understand the frequency and use of the word "leadership" in job descriptions. Using…

  5. The Entrepreneurial Process: An International Analysis of Entry and Exit

    NARCIS (Netherlands)

    P.W. van der Zwan (Peter)


    textabstractThis thesis deals with the entrepreneurial process from an international perspective. The first part explores which people decide to enter entrepreneurship. A distinction is made between two modes of entrepreneurial entry: taking over an existing firm and starting a new firm. The second

  6. Age at school entry and intergenerational educational mobility


    Philipp C. Bauer; Riphahn, Regina T.


    We use Swiss data to test whether intergenerational educational mobility is affected by the age at which children first enter (primary) school. Early age at school entry significantly affects mobility and reduces the relative advantage of children of better educated parents.

  7. How Dictionary Users Choose Senses in Bilingual Dictionary Entries ...

    African Journals Online (AJOL)

    Throughout the task, an eye-tracking device unobtrusively recorded their gaze patterns, which are analyzed and discussed. Both successful and unsuccessful searches are examined. Also, we assess the potential of eye-tracking technology in the study of dictionary use. Keywords: eye tracking, bilingual dictionary, entry ...

  8. 40 CFR 86.1849-01 - Right of entry. (United States)


    ... Provisions for Control of Air Pollution From New and In-Use Light-Duty Vehicles, Light-Duty Trucks, and... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Right of entry. 86.1849-01 Section 86.1849-01 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED...

  9. Voices of Women at Entry Level Positions of Educational Administration. (United States)

    Hackney, Catherine Eggleston


    This paper examines the effects of organizational culture on women's professional lives. It focuses on women in entry-level positions in educational administration and explores the interaction of organizational attitudes and expectations with the participants' personalities, epistemological positions, work needs, performance self-esteem, and sense…

  10. Application of an Aesthetic Evaluation Model to Data Entry Screens. (United States)

    Ngo, D. C. L.; Byrne, J. G.


    Describes a new model for quantitatively assessing screen formats. Results of applying the model to data entry screens support the use of the model. Also described is a critiquing mechanism embedded in a user interface design environment as a demonstration of this approach. (Author/AEF)

  11. On satellite umbra/penumbra entry and exit positions


    Neta, Beny; Vellado, David


    The problem of computing Earth satellite entry and exit positions through the Earth's umbra and penumbra, for satellites in elliptical orbits, is solved without the use of a quartic equation. A condition for existence of a solution is given. This problem is related to perturbation force resulting from solar radiation pressure.

  12. Cygnus Code Simulation of Magnetoshell Aerocapture and Entry System (United States)

    Shimazu, Akihisa; Kirtley, David; Barnes, Dan; Slough, John


    A Magnetoshell Aerocapture and Entry System (MAC) is a novel concept for planetary atmospheric entry, which enables both manned and planetary deep space orbiter space missions that are difficult with present day technologies. The MAC uses a low-beta dipole plasma magnetoshell to produce a drag effect on the spacecraft through the collisional interactions between the entry atmospheric neutrals and the confined plasma in the magnetoshell, creating a dynamic and controllable plasma parachute for entry. To understand the performance and the behavior of the MAC, the Cygnus 2D Hall MHD code is used for this study. The Cygnus code is a 2D Hall MHD code with coupled external circuits, which has been originally developed for studying FRC formation, translation, merging, and compression. In this study, the Cygnus code is modified to support the MAC geometry with a simplified plasma-neutral model that accounts for electron-impact ionization, radiative recombination, and resonant charge exchange to simulate the collisional interaction processes for the MAC.

  13. From nascent to actual entrepreneurship: the effect of entry barriers

    NARCIS (Netherlands)

    A.J. van Stel (André); D. Storey (David); A.R.M. Wennekers (Sander); A.R. Thurik (Roy)


    textabstractThis exploratory study focuses on the conversion from nascent to actual entrepreneurship and the role of entry barriers in this process. Using data for a sample of countries participating in the Global Entrepreneurship Monitor between 2002 and 2004, we estimate a twoequation model

  14. A new approach to orientation: professional entry into practice. (United States)

    Bowers, Bendi; Bennett, Sandra S; Schneider, Sharon K; Brunner, Barbie W


    With a strong emphasis on the overall recruitment and retention of staff, the University of Arkansas for Medical Sciences, Clinical Programs Staff Education Department, developed a new orientation program: "Professional Entry Into Practice." This article provides the model to review current orientation processes and to revise and evaluate new orientation processes.

  15. Candidate Medical Countermeasures Targeting Ebola Virus Cell Entry (United States)


    vesiculoviruses in vitro [96]. 261 The pharmacokinetic profile of K11777 in rodents, dogs , and nonhuman primates is suggestive 262 of its safety in humans [97...2123-2131 (2014). 600 89. Wolf MC, Freiberg AN, Zhang T et al. A broad-spectrum antiviral targeting entry of 601 enveloped viruses. Proc. Natl. Acad

  16. Oblique water entry of a three dimensional body

    Directory of Open Access Journals (Sweden)

    Scolan Yves-Marie


    Full Text Available The problem of the oblique water entry of a three dimensional body is considered. Wagner theory is the theoretical framework. Applications are discussed for an elliptic paraboloid entering an initially flat free surface. A dedicated experimental campaign yields a data base for comparisons. In the present analysis, pressure, force and dynamics of the wetted surface expansion are assessed.

  17. Late entry to antenatal care in New South Wales, Australia

    Directory of Open Access Journals (Sweden)

    Rubin George


    Full Text Available Abstract Aims This study aimed to assess the prevalence of women who entered antenatal care (ANC late and to identify factors related to the late entry to ANC in New South Wales (NSW in 2004. Methods The NSW Midwives Data Collection contained data of 85,034 women who gave birth in 2004. Data were downloaded using SAS and transferred to STATA 8.0. Entering ANC after 12 weeks of gestation was classified as late. The Andersen Health Seeking Behaviour Model was used for selection and analyses of related factors. Regression and hierarchical analyses were used to identify significant factors and their relative contributions to the variation of pregnancy duration at entry to ANC. Results 41% of women commenced ANC after 12 weeks of gestation. Inequality existed between groups of women with predisposing characteristics and enabling resources contributed more to the variation in pregnancy duration at entry to ANC than needs. The groups of women with highest risk were teenagers, migrants from developing countries, women living in Western Sydney, Aboriginal and Torres Strait Islanders, women with three or more previous pregnancies and heavy smokers. The high risk groups with largest number of women were migrants from developing countries and women living in Western Sydney. Conclusion A large number of women in NSW entered ANC late in their pregnancies. Efforts to increase early entry to ANC should be targeted on identified high risk groups of women.

  18. Cones of Games arising from Market Entry Problems

    NARCIS (Netherlands)

    Brânzei, R.; Tijs, S.H.; Timmer, J.B.


    Market entry situations are modelled, where an entrepreneur has to decide for a collection of markets which market to enter and which not. The entrepreneur can improve his prior information by making use of a group of informants, each of them knowing the situation in one or more markets. For such a

  19. Entry Level Systems Analysts: What Does the Industry Want?

    Directory of Open Access Journals (Sweden)

    Donna M. Grant


    Full Text Available This study investigates the skill sets necessary for entry level systems analysts. Towards this end, the study combines two sources of data, namely, a content analysis of 200 systems analysts’ online job advertisements and a survey of 20 senior Information Systems (IS professionals. Based on Chi-square tests, the results reveal that most employers prefer entry level systems analysts with an undergraduate Computer Science degree. Furthermore, most of the employers prefer entry level systems analysts to have some years of experience as well as industry certifications. The results also reveal that there is a higher preference for entry level systems analysts who have non-technical and people skills (e.g., problem solving and oral communication. The empirical results from this study will inform IS educators as they develop future systems analysts. Additionally, the results will be useful to the aspiring systems analysts who need to make sure that they have the necessary job skills before graduating and entering the labor market.

  20. The University of Sydney Library Catalogue Data Entry System. (United States)

    Jacob, M. E. L.; And Others


    This report is a description of the history, development, and present state of the University of Sydney Library Catalog Data Entry System. The system has been designed for use on an IBM System 360/20 using assembler programing language. While its primary objective is the generation of machine-readable catalogs, a byproduct of the system has been…

  1. Rift Valley Fever Virus Glycoproteins, Key to Entry and Control

    NARCIS (Netherlands)

    de Boer, S.M.


    In this thesis we have focussed on the RVFV Gn and Gc glycoproteins, the keys for virus entry and virus control. RVFV is an emerging virus that has already spread across the African continent and to the Arabian Peninsula. Outbreaks of RVFV are characterized by abortion storms and high mortality,

  2. 46 CFR 14.305 - Entries in continuous discharge book. (United States)


    ... 46 Shipping 1 2010-10-01 2010-10-01 false Entries in continuous discharge book. 14.305 Section 14.305 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN SHIPMENT... discharge book. If the merchant mariner holds a continuous discharge book, the master or individual in...

  3. Field performance of three peanut entries in Oklahoma (United States)

    Peanut entries (Tamrun 96, Tamrun OL02, and TX 994313) were among peanut lines included in four tests in 2006 and 2007. Plots were planted during May and harvested in late September to mid October to attain a growing season of 155 days. Plots were arranged in a complete randomized block design wit...

  4. Essential Entry-Level Skills for Systems Analysts (United States)

    Banerjee, Sarbani; Lin, William


    In this study, the authors provide some details about a variety of entry-level skills that are vitally important to systems analysts. They gathered the data from information technology practitioners, who related their experiences with real-world systems development projects. Such empirical evidence may be useful to faculty as they decide which…

  5. Parachute triggering algorithms for re-entry vehicles

    NARCIS (Netherlands)

    Ording, B.E.; Sudars, M.; Brouwer, G.F.


    Most re-entry vehicles utilize a Descent and Landing System (DLS) for a safe descent through the lowest part of the atmosphere. It usually requires deployment in a certain suitable range of flight conditions, which has to be estimated by limited means of navigation. This paper presents a comparison

  6. Does competitive entry structurally change key marketing metrics?

    NARCIS (Netherlands)

    Kornelis, Marcel; Dekimpe, Marnik G.; Leeflang, Peter S. H.

    To what extent does competitive entry create a structural change in key marketing metrics? New players mayjust be a temporal nuisance to incumbents, but could also fundamentally change the latter's performance evolution, or induce them to permanently alter their spending levels and/or pricing

  7. Integrated alarm annunciation and entry control systems -- Survey results

    Energy Technology Data Exchange (ETDEWEB)

    Clever, J.J.; Arakaki, L.H.; Monaco, F.M.; Juarros, L.E.; Quintana, G.R.


    This report provides the results and analyses of a detailed survey undertaken in Summer 1993 to address integrated intrusion detection alarm annunciation and entry control system issues. This survey was undertaken as a first attempt toward beginning to answer questions about integrated systems and commercial capabilities to meet or partially meet US Department of Energy (DOE) site needs.

  8. 19 CFR 147.43 - Entry under the Customs laws. (United States)


    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Entry under the Customs laws. 147.43 Section 147.43 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF... the Customs laws. (a) Payment of duties and taxes. Any applicable duties and internal revenue taxes on...

  9. Largest Two Entries in a Row and Column

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 5; Issue 2. Largest Two Entries in a Row and Column. R B Bapat. Classroom Volume 5 Issue 2 February 2000 pp 68-71. Fulltext. Click here to view fulltext PDF. Permanent link: Author Affiliations.

  10. Widening Participation and Contextual Entry Policy in Accounting and Finance (United States)

    Rowbottom, N.


    The paper examines the performance of accounting and finance students entering university via a "widening participation" scheme that seeks to attract students who have been historically under-represented in higher education. Focus is placed on the policy of providing contextual entry offers that recognise that academic qualifications be…

  11. Data link relay design. [space probe with entry at Uranus (United States)

    Parsons, P.


    The data link for the Ames baseline probe as applied to the MJU spacecraft specifically with an entry at Uranus is analyzed. A frequency analysis, a trajectory analysis, and a discussion of the effects on the spacecraft design by the data link are presented. The possibilities of a two-way link are considered.

  12. SME's perceptions regarding strategic and structural entry barriers

    NARCIS (Netherlands)

    Lutz, Clemens; Kemp, Ron; Dijkstra, S. Gerhard


    Abstract Extant literature discusses a large number of different entry barriers that may hamper market efficiency or entrepreneurial activity. In practice several of these barriers cohere and stem from the same root. Factor analysis is used to identify the underlying dimensions of these barriers. 7

  13. Love me tender: new entry in popular music

    NARCIS (Netherlands)

    Mol, J.; Chiu, M.M.; Wijnberg, N.


    The purpose of this paper is to investigate new entry as a process of organizational change against the background of the digital revolution in the music industry. The study analyzes questionnaire data gathered from 131 companies active in the Dutch music industry that collectively engaged in 215


    Directory of Open Access Journals (Sweden)

    E. V. Maslennikov


    Full Text Available The article outlines some of the possible ways of integrating the deployment tool conceptualizing domains of sociology on the basis of the machine sets of steps3. Substantiates the urgency of the problem of application of structural constructs of mathematics as a structure-formalism domain of sociology as a combination of theoretical knowledge. Formulated understanding of the sociological dimension in a broad sense of the concept of research as a measurement based on the use of instrumental in conceptualizing the methodology of sociological research. Under instrumental conceptualization refers to the construction of complex conceptual (conceptual schema structurally interconnected relationships between their individual elements, which are the units of the consideration related conceptual integrity, derived from interpretation of the properties “Set” construct. The paper proposes a definition based on the properties set in the scale set by the structure of N. Bourbaki4 relations systems in the data sets under the structural dimension of social phenomena to understand the interpretation of the investigated properties of social phenomena in terms of a construct that lies at the basis of the theoretical model that reflects the diversity of these qualities with the help of conceptual schemes that determine the quality of each as a structure of relations systems (ie, property in these qualities. In conclusion, the article lists presented in a number of publications, some preliminary results of the application of the methodology of conceptualizing instrumental in related disciplines from sociology. These works can perform suggestive role in the knowledge and understanding of methods of problem fields and objectives of the work on the conceptualization of theoretical sociology, using the mathematical theory of forms. 

  15. Characteristics of Open Access Journals in Six Subject Areas (United States)

    Walters, William H.; Linvill, Anne C.


    We examine the characteristics of 663 Open Access (OA) journals in biology, computer science, economics, history, medicine, and psychology, then compare the OA journals with impact factors to comparable subscription journals. There is great variation in the size of OA journals; the largest publishes more than 2,700 articles per year, but half…

  16. Occupational Listings Arranged by Cluster and Subject Matter Areas. (United States)

    Schwarz, Otto

    Approximately 850 occupations are listed under 27 occupational clusters. The Dictionary of Occupational Title (DOT) number is specified for occupations in the clusters of business training and distributive education, chemistry, general shop and industrial arts, home economics, foreign language, music, social studies, art, agriculture, physics, and…

  17. School Librarians Teach Subject Area 10: Computer and Information Sciences (United States)

    Dow, Mirah J. Ingram


    School librarians currently speak about school libraries as the largest classroom in the building. If so, how can these librarians describe what they teach? This article explains the user-centered instructional role of secondary school librarians in teaching information and technology literacy skills, as well as how they can authoritatively ensure…


    Directory of Open Access Journals (Sweden)

    Jusuf ZEKIRI


    Full Text Available Organizations that operate in international markets need to make the most important decisions in order to select a best mode of entry into foreign markets. This paper attempts to clarify some of the issues arising in international market selection. A firm must assess before entering a particular market the motives and  potential factors that play a significant role during the process of decision making for market selection. An overview of the current methodologies for market selection based on the literature on international marketing is provided. Therefore, the main objective of the paper is to outline and discuss the relevant issues and challenges from a theoretical viewpoint related with the possible entry modes into international and global markets. This paper concentrates on secondary sources of research regarding the internationalisation of businesses.  According to the previous literature, scholars have already found out some of determinants influencing the efficiency of foreign entry, such as: economic factors, political risk, legal factors, cultural factor, international experience, etc. A model can be outlined from the theoretical viewpoints about the advantages and disadvantage of each foreign market entry strategy discussed. One of the fundamental steps that need to be taken prior to beginning international marketing is the environmental analysis. There are uncontrollable forces which are external forces upon which the management has no direct control, although it can exert an influence. Internal forces are controllable forces upon which the management administers to adapt to changes in the uncontrollable forces. The conclusion will provide a short summary of identified key elements that need to be considered by management in choosing international markets and their foreign market entry modes.

  19. A novel small molecule inhibitor of hepatitis C virus entry.

    Directory of Open Access Journals (Sweden)

    Carl J Baldick

    Full Text Available Small molecule inhibitors of hepatitis C virus (HCV are being developed to complement or replace treatments with pegylated interferons and ribavirin, which have poor response rates and significant side effects. Resistance to these inhibitors emerges rapidly in the clinic, suggesting that successful therapy will involve combination therapy with multiple inhibitors of different targets. The entry process of HCV into hepatocytes represents another series of potential targets for therapeutic intervention, involving viral structural proteins that have not been extensively explored due to experimental limitations. To discover HCV entry inhibitors, we utilized HCV pseudoparticles (HCVpp incorporating E1-E2 envelope proteins from a genotype 1b clinical isolate. Screening of a small molecule library identified a potent HCV-specific triazine inhibitor, EI-1. A series of HCVpp with E1-E2 sequences from various HCV isolates was used to show activity against all genotype 1a and 1b HCVpp tested, with median EC50 values of 0.134 and 0.027 µM, respectively. Time-of-addition experiments demonstrated a block in HCVpp entry, downstream of initial attachment to the cell surface, and prior to or concomitant with bafilomycin inhibition of endosomal acidification. EI-1 was equally active against cell-culture adapted HCV (HCVcc, blocking both cell-free entry and cell-to-cell transmission of virus. HCVcc with high-level resistance to EI-1 was selected by sequential passage in the presence of inhibitor, and resistance was shown to be conferred by changes to residue 719 in the carboxy-terminal transmembrane anchor region of E2, implicating this envelope protein in EI-1 susceptibility. Combinations of EI-1 with interferon, or inhibitors of NS3 or NS5A, resulted in additive to synergistic activity. These results suggest that inhibitors of HCV entry could be added to replication inhibitors and interferons already in development.

  20. Filovirus Entry: A Novelty in the Viral Fusion World

    Directory of Open Access Journals (Sweden)

    Wendy Maury


    Full Text Available Ebolavirus (EBOV and Marburgvirus (MARV that compose the filovirus family of negative strand RNA viruses infect a broad range of mammalian cells. Recent studies indicate that cellular entry of this family of viruses requires a series of cellular protein interactions and molecular mechanisms, some of which are unique to filoviruses and others are commonly used by all viral glycoproteins. Details of this entry pathway are highlighted here. Virus entry into cells is initiated by the interaction of the viral glycoprotein1 subunit (GP1 with both adherence factors and one or more receptors on the surface of host cells. On epithelial cells, we recently demonstrated that TIM-1 serves as a receptor for this family of viruses, but the cell surface receptors in other cell types remain unidentified. Upon receptor binding, the virus is internalized into endosomes primarily via macropinocytosis, but perhaps by other mechanisms as well. Within the acidified endosome, the heavily glycosylated GP1 is cleaved to a smaller form by the low pH-dependent cellular proteases Cathepsin L and B, exposing residues in the receptor binding site (RBS. Details of the molecular events following cathepsin-dependent trimming of GP1 are currently incomplete; however, the processed GP1 specifically interacts with endosomal/lysosomal membranes that contain the Niemann Pick C1 (NPC1 protein and expression of NPC1 is required for productive infection, suggesting that GP/NPC1 interactions may be an important late step in the entry process. Additional events such as further GP1 processing and/or reducing events may also be required to generate a fusion-ready form of the glycoprotein. Once this has been achieved, sequences in the filovirus GP2 subunit mediate viral/cellular membrane fusion via mechanisms similar to those previously described for other enveloped viruses. This multi-step entry pathway highlights the complex and highly orchestrated path of internalization and fusion that

  1. 30 CFR 717.14 - Backfilling and grading of road cuts, mine entry area cuts, and other surface work areas. (United States)


    ... growth and land uses. Where necessary to protect against upward migration of salts, exposure by erosion... to prevent leaching of toxic pollutants. Barren rock or similar materials excess to the mining...) Retain all earth, rock and other mineral nonwaste materials on the solid portion of existing or new...

  2. Memories of the Ottoman Empires Entry into the First World War

    Directory of Open Access Journals (Sweden)

    Mehmet BİÇİCİ


    Full Text Available The Ottoman Empire's entry into the First World War and how it occurs in a process and the conditions under which the subject is extremely important in terms of recent history. Because the First World War, six centuries has resulted in the liquidation of the Ottoman Empire. From the Armistice more ink drying and Sevre paved the way for foreign occupation and intervention has led to the Turkish War of Independence. An independent state under the debris of destroyed large Turkey, under the leadership of Ataturk many years with great dedication and achievement are established by the National Struggle. It is therefore that the Ottoman Empire's entry into the war, perhaps more than the war itself were discussed. Today we rotate back to relive the events is not possible. But good to analyze what happened , they take lessons from this day to try to make the right decisions is the duty of the Turkish nation. Already Republic of Turkey, The lessons of these events have taken, II. World War didn‟t enter


    Energy Technology Data Exchange (ETDEWEB)

    Dugan, J; Debbie Chapman, D


    properly latch doors and barriers. It is a compelling product for households with children, elderly, or high traffic areas such as an office where a properly closed and latched door is essential for security and safety. In an age of ever increasing security concerns and limited human resources, Smart Latch{trademark} can be a significant addition to the $20 billion plus industrial and consumer lockset market. The Smart Latch{trademark} is unique because: (1) as an inexpensive, battery powered, stand-alone device or as integrated into any standard consumer lock set, the device uses neural network technology to analyze the acoustic signatures associated with normal door operation and generates an alert if a door is not latched correctly and within a set amount of time. (2) It is not easily spoofed or defeated. (3) Installation, setup, and use are simple.

  4. Subject (of documents)

    DEFF Research Database (Denmark)

    Hjørland, Birger


    such as concepts, aboutness, topic, isness and ofness are also briefly presented. The conclusion is that the most fruitful way of defining “subject” (of a document) is the documents informative or epistemological potentials, that is, the documents potentials of informing users and advance the development......This article presents and discuss the concept “subject” or subject matter (of documents) as it has been examined in library and information science (LIS) for more than 100 years. Different theoretical positions are outlined and it is found that the most important distinction is between document......-oriented views versus request-oriented views. The document-oriented view conceive subject as something inherent in documents, whereas the request-oriented view (or the policy based view) understand subject as an attribution made to documents in order to facilitate certain uses of them. Related concepts...

  5. Science of the subjective. (United States)

    Jahn, R G; Dunne, B J


    Over the greater portion of its long scholarly history, the particular form of human observation, reasoning, and technical deployment we properly term "science" has relied at least as much on subjective experience and inspiration as it has on objective experiments and theories. Only over the past few centuries has subjectivity been progressively excluded from the practice of science, leaving an essentially secular analytical paradigm. Quite recently, however, a compounding constellation of newly inexplicable physical evidence, coupled with a growing scholarly interest in the nature and capability of human consciousness, are beginning to suggest that this sterilization of science may have been excessive and could ultimately limit its epistemological reach and cultural relevance. In particular, an array of demonstrable consciousness-related anomalous physical phenomena, a persistent pattern of biological and medical anomalies, systematic studies of mind/brain relationships and the mechanics of human creativity, and a burgeoning catalogue of human factors effects within contemporary information processing technologies, all display empirical correlations with subjective aspects that greatly complicate, and in many cases preclude, their comprehension on strictly objective grounds. However, any disciplined re-admission of subjective elements into rigorous scientific methodology will hinge on the precision with which they can be defined, measured, and represented, and on the resilience of established scientific techniques to their inclusion. For example, any neo-subjective science, while retaining the logical rigor, empirical/theoretical dialogue, and cultural purpose of its rigidly objective predecessor, would have the following requirements: acknowledgment of a proactive role for human consciousness; more explicit and profound use of interdisciplinary metaphors; more generous interpretations of measurability, replicability, and resonance; a reduction of ontological

  6. The FachRef-Assistant: Personalised, subject specific, and transparent stock management

    Directory of Open Access Journals (Sweden)

    Eike T. Spielberg


    Full Text Available We present in this paper a personalized web application for the weeding of printed resources: the FachRef-Assistant. It offers an extensive range of tools for evidence based stock management, based on the thorough analysis of usage statistics. Special attention is paid to the criteria individualization, transparency of the parameters used, and generic functions. Currently, it is designed to work with the Aleph-System from ExLibris, but efforts were spent to keep the application as generic as possible. For example, all procedures specific to the local library system have been collected in one Java package. The inclusion of library specific properties such as collections and systematics has been designed to be highly generic as well by mapping the individual entries onto an in-memory database. Hence simple adaption of the package and the mappings would render the FachRef-Assistant compatible to other library systems. The personalization of the application allows for the inclusion of subject specific usage properties as well as of variations between different collections within one subject area. The parameter sets used to analyse the stock and to prepare weeding and purchase proposal lists are included in the output XML-files to facilitate a high degree of transparency, objectivity and reproducibility.

  7. Violence against women: a relation between subjective dimensions and the production of information

    Directory of Open Access Journals (Sweden)

    Mariana de Lima Campos


    Full Text Available The violence against women is considered a social issue and affects the lives of millions of women in their different areas of acting. An important mechanism to identify and diagnose incidents related to this phenomenon are the information and communication systems in the public sector because allow the mapping of cases, the construction of indicators and an idea of the magnitude of the problem, allowing therefore , building more effective initiatives related to its combat. The point to be emphasized is about data produced and inserted in these systems, keeping in mind the influence of subjective dimensions derived values, beliefs, meanings and meanings attributed to violence against women. Through a literature review and documentary on the subject, the analysis refers to the inclusion of data in the Sistema de Informações de Agravos de Notificação (SINAN, the Ministry of Health. It is believed that values  established culturally in society are reflected in the information produced and higher level, the existence of underreporting, establishing itself as one of the negative aspects related to data entry into the system and to combat with violence against women. It is understood that these facts refer to a historical and cultural vision marked by evaluative concepts regarding hierarchical gender patterns impacting on the procedures of the systems and commitment of professionals with the purposes established for their services.

  8. The Subjectivity of Participation

    DEFF Research Database (Denmark)

    Nissen, Morten

    What is a 'we' – a collective – and how can we use such communal self-knowledge to help people? This book is about collectivity, participation, and subjectivity – and about the social theories that may help us understand these matters. It also seeks to learn from the innovative practices and ideas...... practices. Through this dialogue, it develops an original trans-disciplinary critical theory and practice of collective subjectivity for which the ongoing construction and overcoming of common sense, or ideology, is central. It also points to ways of relating discourse with agency, and fertilizing insights...... from interactionism and ideology theories in a cultural-historical framework....

  9. Role of Pulse Pressure and Geometry of Primary Entry Tear in Acute Type B Dissection Propagation. (United States)

    Peelukhana, Srikara V; Wang, Yanmin; Berwick, Zachary; Kratzberg, Jarin; Krieger, Joshua; Roeder, Blayne; Cloughs, Rachel E; Hsiao, Albert; Chambers, Sean; Kassab, Ghassan S


    The hemodynamic and geometric factors leading to propagation of acute Type B dissections are poorly understood. The objective is to elucidate whether geometric and hemodynamic parameters increase the predilection for aortic dissection propagation. A pulse duplicator set-up was used on porcine aorta with a single entry tear. Mean pressures of 100 and 180 mmHg were used, with pulse pressures ranging from 40 to 200 mmHg. The propagation for varying geometric conditions (%circumference of the entry tear: 15-65%, axial length: 0.5-3.2 cm) were tested for two flap thicknesses (1/3rd and 2/3rd of the thickness of vessel wall, respectively). To assess the effect of pulse and mean pressure on flap dynamics, the %true lumen (TL) cross-sectional area of the entry tear were compared. The % circumference for propagation of thin flap (47 ± 1%) was not significantly different (p = 0.14) from thick flap (44 ± 2%). On the contrary, the axial length of propagation for thin flap (2.57 ± 0.15 cm) was significantly different (p propagation was calculated as 75 ± 9 J/m2 and was fairly uniform across different specimens. Pulse pressure had a significant effect on the flap movement in contrast to mean pressure. Hence, mitigation of pulse pressure and restriction of flap movement may be beneficial in patients with type B acute dissections.

  10. Specific regulation of the chemokine response to viral hemorrhagic septicemia virus at the entry site. (United States)

    Montero, Jana; Garcia, Jessica; Ordas, M Camino; Casanova, Isabel; Gonzalez, Antonia; Villena, Alberto; Coll, Julio; Tafalla, Carolina


    The fin bases constitute the main portal of rhabdovirus entry into rainbow trout (Oncorhynchus mykiss), and replication in this first site strongly conditions the outcome of the infection. In this context, we studied the chemokine response elicited in this area in response to viral hemorrhagic septicemia virus (VHSV), a rhabdovirus. Among all the rainbow trout chemokine genes studied, only the transcription levels of CK10 and CK12 were significantly upregulated in response to VHSV. As the virus had previously been shown to elicit a much stronger chemokine response in internal organs, we compared the effect of VHSV on the gills, another mucosal site which does not constitute the main site of viral entry or rhabdoviral replication. In this case, a significantly stronger chemokine response was triggered, with CK1, CK3, CK9, and CK11 being upregulated in response to VHSV and CK10 and CK12 being down-modulated by the virus. We then conducted further experiments to understand how these different chemokine responses of mucosal tissues could correlate with their capacity to support VHSV replication. No viral replication was detected in the gills, while at the fin bases, only the skin and the muscle were actively supporting viral replication. Within the skin, viral replication took place in the dermis, while viral replication was blocked within epidermal cells at some point before protein translation. The different susceptibilities of the different skin layers to VHSV correlated with the effect that VHSV has on their capacity to secrete chemotactic factors. Altogether, these results suggest a VHSV interference mechanism on the early chemokine response at its active replication sites within mucosal tissues, a possible key process that may facilitate viral entry.

  11. Impact of the time span selected to calibrate the ballistic parameter on spacecraft re-entry predictions (United States)

    Pardini, C.; Anselmo, L.

    The trajectory modeling of satellites that are re-entering the Earth’s atmosphere, as a result of natural orbital decay, has always been a challenging task. Residual lifetime estimations and re-entry predictions are affected by substantial uncertainties, associated with atmospheric density models, with the forecasts of the relevant solar and geomagnetic activity indices and with tracking data, which for uncontrolled re-entries are usually sparse and not particularly accurate. Furthermore, modeling the aerodynamic forces that act on low altitude satellites is a formidable task, especially for objects of a complex shape and unknown attitude evolution. The ballistic parameter, defined as B = CDA/M, where CD, A and M are, respectively, the satellite drag coefficient, cross-sectional area and mass, incorporates the uncertainties related to the physical characteristics and attitude of the satellite, as well as the complicated interaction between air molecules and satellite surface. Since the uncertainties affecting the drag force computation are driven mainly by the product of air density and ballistic parameter, the latter may be adjusted so as to force the atmospheric density model to agree with the air drag revealed by the tracking data. Thus, the value of B that gives the best numerical fit between the estimated and the observed orbit, in a given time/data span, can be used to propagate the last available state vector, so as to calculate the satellite’s residual lifetime. However, the value of B may fluctuate from one data fit span to another, depending both on how the true density differs from the modeled one and on the possible changes in the satellite’s attitude. Of course, different values of B can be seen in different estimations of the satellite’s lifetime and re-entry epoch. Therefore, the choice of any suitable time/data span to calibrate the ballistic parameter is very tricky during a re-entry campaign. In an attempt to assess the impact of the

  12. Secondary School Science Predictors of Academic Performance in University Bioscience Subjects (United States)

    Green, Rod; Brown, Elizabeth; Ward, Alex


    In 2009 the Faculty of Health Sciences at La Trobe University in Melbourne, Australia is introducing a common first year for 11 different undergraduate courses in the faculty. Current prerequisite science entry requirements vary with course and range from none to at least two science or mathematics subjects and from [approximately]50 to 99 in…

  13. A Comparison Study of the Pedagogical Content Knowledge of Single Subject Mathematics Credential Candidates (United States)

    Vierra, Vicki Ann


    This descriptive study compares the entry-level pedagogical content knowledge of single subject mathematics credential candidates based on career status and undergraduate majors. Career changers from science, technology, engineering or math (STEM) fields are compared to first career candidates to see if they bring different skills and knowledge to…

  14. Paying Hypertension Research Subjects (United States)

    Casarett, David; Karlawish, Jason; Asch, David A


    CONTEXT Cash payments are often used to compensate subjects who participate in research. However, ethicists have argued that these payments might constitute an undue inducement. OBJECTIVES To determine whether potential subjects agree with theoretical arguments that a payment could be an undue inducement. DESIGN/SETTING/PARTICIPANTS Survey of 350 prospective jurors. MAIN OUTCOME MEASURES Belief that a $500 payment for research participation would impair their own, and others' ability to think carefully about the risks and benefits of a clinical trial. RESULTS Two hundred sixty-one jurors (74.6%) believed that a $500 payment would impair subjects' ability to think carefully about the risks and benefits of research. Ninety-six of 120 (80%) expressed this concern about subjects with a low income ($50,000). In contrast, only 69 (19.7%) of jurors believed that a $500 payment would influence them. Jurors who believed that this payment would influence them reported lower incomes and less education. CONCLUSION Members of the general public share ethical concerns about the influence of payments for research, although they believe that these concerns are more applicable to others than to themselves.

  15. Subjects, Models, Languages, Transformations

    NARCIS (Netherlands)

    Rensink, Arend; Bézivin, J.; Heckel, R.


    Discussions about model-driven approaches tend to be hampered by terminological confusion. This is at least partially caused by a lack of formal precision in defining the basic concepts, including that of "model" and "thing being modelled" - which we call subject in this paper. We propose a minimal

  16. Subjective Duration and Psychophysics (United States)

    Eisler, Hannes


    Three models are proposed to describe the strategy applied by a subject when he is confronted with two successive time intervals and is required to deal with some relation between them, for example, by telling which was the longer by adjusting the second to match the first. (Author)

  17. Barron's SAT subject test

    CERN Document Server

    Jansen, MA, Robert


    Includes one diagnostic test and three complete tests, all questions answered and explained, self-assessment guides, and subject reviews. Also features test strategies, QR codes to short instructional videos, and a detailed appendix with equations, physical constants, and a basic math review.

  18. Parametric Thermal Soak Model for Earth Entry Vehicles (United States)

    Agrawal, Parul; Samareh, Jamshid; Doan, Quy D.


    The analysis and design of an Earth Entry Vehicle (EEV) is multidisciplinary in nature, requiring the application many disciplines. An integrated tool called Multi Mission System Analysis for Planetary Entry Descent and Landing or M-SAPE is being developed as part of Entry Vehicle Technology project under In-Space Technology program. Integration of a multidisciplinary problem is a challenging task. Automation of the execution process and data transfer among disciplines can be accomplished to provide significant benefits. Thermal soak analysis and temperature predictions of various interior components of entry vehicle, including the impact foam and payload container are part of the solution that M-SAPE will offer to spacecraft designers. The present paper focuses on the thermal soak analysis of an entry vehicle design based on the Mars Sample Return entry vehicle geometry and discusses a technical approach to develop parametric models for thermal soak analysis that will be integrated into M-SAPE. One of the main objectives is to be able to identify the important parameters and to develop correlation coefficients so that, for a given trajectory, can estimate the peak payload temperature based on relevant trajectory parameters and vehicle geometry. The models are being developed for two primary thermal protection (TPS) materials: 1) carbon phenolic that was used for Galileo and Pioneer Venus probes and, 2) Phenolic Impregnated Carbon Ablator (PICA), TPS material for Mars Science Lab mission. Several representative trajectories were selected from a very large trade space to include in the thermal analysis in order to develop an effective parametric thermal soak model. The selected trajectories covered a wide range of heatload and heatflux combinations. Non-linear, fully transient, thermal finite element simulations were performed for the selected trajectories to generate the temperature histories at the interior of the vehicle. Figure 1 shows the finite element model

  19. 50 CFR 91.13 - Technical requirements for design and submission of entry. (United States)


    ..., DEPARTMENT OF THE INTERIOR (CONTINUED) MISCELLANEOUS PROVISIONS MIGRATORY BIRD HUNTING AND CONSERVATION STAMP... entry. The design must be a horizontal drawing or painting 7 inches high and 10 inches wide. The entry...

  20. Encyclopaedia Entries for: (1) Spa Tourism, (2) Backpacker Tourism and (3) Country Profile: Ireland


    Kelly, Catherine


    These entries detail definitional terms for spa tourism, backpacker tourism and an overview of tourism in the Irish Republic. Key trends, main products, visitor numbers and attractions are outlined in each concise entry for this extensive encyclopaedia.