Sample records for subdominant influenza-specific response

  1. Decline of influenza-specific CD8+ T cell repertoire in healthy geriatric donors

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    Ramachandra Lakshmi


    Full Text Available Abstract Background While influenza vaccination results in protective antibodies against primary infections, clearance of infection is primarily mediated through CD8+ T cells. Studying the CD8+ T cell response to influenza epitopes is crucial in understanding the disease associated morbidity and mortality especially in at risk populations such as the elderly. We compared the CD8+ T cell response to immunodominant and subdominant influenza epitopes in HLA-A2+ control, adult donors, aged 21-42, and in geriatric donors, aged 65 and older. Results We used a novel artificial Antigen Presenting Cell (aAPC based stimulation assay to reveal responses that could not be detected by enzyme-linked immunosorbent spot (ELISpot. 14 younger control donors and 12 geriatric donors were enrolled in this study. The mean number of influenza-specific subdominant epitopes per control donor detected by ELISpot was only 1.4 while the mean detected by aAPC assay was 3.3 (p = 0.0096. Using the aAPC assay, 92% of the control donors responded to at least one subdominant epitopes, while 71% of control donors responded to more than one subdominant influenza-specific response. 66% of geriatric donors lacked a subdominant influenza-specific response and 33% of geriatric donors responded to only 1 subdominant epitope. The difference in subdominant response between age groups is statistically significant (p = 0.0003. Conclusion Geriatric donors lacked the broad, multi-specific response to subdominant epitopes seen in the control donors. Thus, we conclude that aging leads to a decrease in the subdominant influenza-specific CTL responses which may contribute to the increased morbidity and mortality in older individuals.

  2. Modulation of innate immune responses by influenza-specific ovine polyclonal antibodies used for prophylaxis.

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    Catherine Rinaldi

    Full Text Available In the event of a novel influenza A virus pandemic, prophylaxis mediated by antibodies provides an adjunct control option to vaccines and antivirals. This strategy is particularly pertinent to unvaccinated populations at risk during the lag time to produce and distribute an effective vaccine. Therefore, development of effective prophylactic therapies is of high importance. Although previous approaches have used systemic delivery of monoclonal antibodies or convalescent sera, available supply is a serious limitation. Here, we have investigated intranasal delivery of influenza-specific ovine polyclonal IgG antibodies for their efficacy against homologous influenza virus challenge in a mouse model. Both influenza-specific IgG and F(ab'2 reduced clinical scores, body weight loss and lung viral loads in mice treated 1 hour before virus exposure. Full protection from disease was also observed when antibody was delivered up to 3 days prior to virus infection. Furthermore, effective prophylaxis was independent of a strong innate immune response. This strategy presents a further option for prophylactic intervention against influenza A virus using ruminants to generate a bulk supply that could potentially be used in a pandemic setting, to slow virus transmission and reduce morbidity associated with a high cytokine phenotype.

  3. Naturally-acquired influenza-specific CD4+ T-cell proliferative responses are impaired in HIV-infected African adults.

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    Kondwani C Jambo

    Full Text Available Seasonal influenza has been associated with greater morbidity and mortality in AIDS patients. Highly-active antiretroviral therapy (HAART has led to some reduction in influenza-related complications but the nature of naturally-acquired T-cell immunity to influenza virus in an African setting, and how this changes with immune reconstitution following HAART is unknown. We measured influenza-specific CD4(+ T-cell immunity in unimmunized HIV-infected Malawian adults and then investigated immune reconstitution following HAART.Peripheral blood mononuclear cells were isolated from HIV-infected and HIV-uninfected Malawian adults. CFSE proliferation and CD154 expression flow cytometry-based assays were used to measure influenza-specific CD4(+ T-cell immunity.We found lower naturally-acquired proliferative influenza-specific CD4(+ T-cell responses in AIDS patients that was also present in asymptomatic HIV-infected adults with relatively high CD4 counts (>350 cells/µl. Influenza-specific CD4(+ T-cell immune reconstitution in HIV-infected patients on HAART for 12 months was poor despite a marked reduction in viral load and an increase in CD4 count. This poor immune reconstitution was characterised by a low influenza-specific proliferative CD4(+ T-cell response and reduced proportions of CD154-expressing influenza-specific CD4(+ T-cells in peripheral blood.Our data suggest that asymptomatic HIV-infected adults may also be at risk of influenza-related complications and that HAART alone may not circumvent this risk in AIDS patients. This study highlights the need to identify possible interventions early in HIV infection to reduce the risk of influenza and to intensify influenza surveillance in these susceptible African populations.

  4. Evaluation of Influenza-Specific Humoral Response by Microbead Array Analysis

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    Yoav Keynan


    Full Text Available RATIONALE: Quantitation and determination of antigen specificity of systemic and mucosal immune responses to influenza vaccination is beneficial for future vaccine development. Previous methods to acquire this information were costly, time consuming and sample exhaustive. The benefits of suspension microbead array (MBA analysis are numerous. The multiplex capabilities of the system conserve time, money and sample, while generating statistically powerful data.

  5. Vaccine Targeting of Subdominant CD8+ T Cell Epitopes Increases the Breadth of the T Cell Response upon Viral Challenge, but May Impair Immediate Virus Control

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    Steffensen, Maria A; Pedersen, Louise Holm; Jahn, Marie Louise


    , hence, a greater efficiency in controlling escape variants. However, to our knowledge the evidence supporting this concept is limited at best. To improve upon this, we used the murine lymphocytic choriomeningitis virus model and adenoviral vectors to compare a vaccine expressing unmodified Ag......As a result of the difficulties in making efficient vaccines against genetically unstable viruses such as HIV, it has been suggested that future vaccines should preferentially target subdominant epitopes, the idea being that this should allow a greater breadth of the induced T cell response and...... to a vaccine expressing the same Ag without its immunodominant epitope. We found that removal of the dominant epitope allowed the induction of CD8(+) T cell responses targeting at least two otherwise subdominant epitopes. Importantly, the overall magnitude of the induced T cell responses was similar, allowing...

  6. Induction of novel CD8+ T-cell responses during chronic untreated HIV-1 infection by immunization with subdominant cytotoxic T-lymphocyte epitopes

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    Kloverpris, Henrik; Karlsson, Ingrid; Bonde, Jesper


    OBJECTIVE:: To investigate the potential to induce additional cytotoxic T-lymphocyte (CTL) immunity during chronic HIV-1 infection. DESIGN:: We selected infrequently targeted or subdominant but conserved HLA-A*0201-binding epitopes in Gag, Pol, Env, Vpu and Vif. These relatively immune silent epi...... lead to stronger and more durable cellular responses to selected epitopes with the potential to control viral replication and prevent disease in HIV-1-infected individuals....

  7. Influenza-specific T cells from older people are enriched in the late effector subset and their presence inversely correlates with vaccine response.

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    Lisa E Wagar

    Full Text Available T cells specific for persistent pathogens accumulate with age and express markers of immune senescence. In contrast, much less is known about the state of T cell memory for acutely infecting pathogens. Here we examined T cell responses to influenza in human peripheral blood mononuclear cells from older (>64 and younger (<40 donors using whole virus restimulation with influenza A (A/PR8/34 ex vivo. Although most donors had pre-existing influenza reactive T cells as measured by IFNγ production, older donors had smaller populations of influenza-responsive T cells than young controls and had lost a significant proportion of their CD45RA-negative functional memory population. Despite this apparent dysfunction in a proportion of the older T cells, both old and young donors' T cells from 2008 could respond to A/California/07/2009 ex vivo. For HLA-A2+ donors, MHC tetramer staining showed that a higher proportion of influenza-specific memory CD8 T cells from the 65+ group co-express the markers killer cell lectin-like receptor G1 (KLRG1 and CD57 compared to their younger counterparts. These markers have previously been associated with a late differentiation state or immune senescence. Thus, memory CD8 T cells to an acutely infecting pathogen show signs of advanced differentiation and functional deterioration with age. There was a significant negative correlation between the frequency of KLRG1(+CD57(+ influenza M1-specific CD8 T cells pre-vaccination and the ability to make antibodies in response to vaccination with seasonal trivalent inactivated vaccine, whereas no such trend was observed when the total CD8(+KLRG1(+CD57(+ population was analyzed. These results suggest that the state of the influenza-specific memory CD8 T cells may be a predictive indicator of a vaccine responsive healthy immune system in old age.

  8. Epitope mapping of Ebola virus dominant and subdominant glycoprotein epitopes facilitates construction of an epitope-based DNA vaccine able to focus the antibody response in mice (United States)


    Epitope mapping of Ebola virus dominant and subdominant glycoprotein epitopes facilitates construction of an epitope-based DNA vaccine able to focus... vaccinated against or infected with EBOV. Using the information obtained along with structural modeling to predict epitope accessibility, we then...constructed two DNA vaccines encoding immunodominant and subdominant epitopes predicted to be accessible on EBOV GP. Although a construct designed to

  9. Dominant CD8+ T-Lymphocyte Responses Suppress Expansion of Vaccine-Elicited Subdominant T Lymphocytes in Rhesus Monkeys Challenged with Pathogenic Simian-Human Immunodeficiency Virus▿ (United States)

    Manuel, Edwin R.; Yeh, Wendy W.; Seaman, Michael S.; Furr, Kathryn; Lifton, Michelle A.; Hulot, Sandrine L.; Autissier, Patrick; Letvin, Norman L.


    Emerging data suggest that a cytotoxic T-lymphocyte response against a diversity of epitopes confers greater protection against a human immunodeficiency virus/simian immunodeficiency virus infection than does a more focused response. To facilitate the creation of vaccine strategies that will generate cellular immune responses with the greatest breadth, it will be important to understand the mechanisms employed by the immune response to regulate the relative magnitudes of dominant and nondominant epitope-specific cellular immune responses. In this study, we generated dominant Gag p11C- and subdominant Env p41A-specific CD8+ T-lymphocyte responses in Mamu-A*01+ rhesus monkeys through vaccination with plasmid DNA and recombinant adenovirus encoding simian-human immunodeficiency virus (SHIV) proteins. Infection of vaccinated Mamu-A*01+ rhesus monkeys with a SHIV Gag Δp11C mutant virus generated a significantly increased expansion of the Env p41A-specific CD8+ T-lymphocyte response in the absence of secondary Gag p11C-specific CD8+ T-lymphocyte responses. These results indicate that the presence of the Gag p11C-specific CD8+ T-lymphocyte response following virus challenge may exert suppressive effects on primed Env p41A-specific CD8+ T-lymphocyte responses. These findings suggest that immunodomination exerted by dominant responses during SHIV infection may diminish the breadth of recall responses primed during vaccination. PMID:19641002

  10. Dominant CD8+ T-lymphocyte responses suppress expansion of vaccine-elicited subdominant T lymphocytes in rhesus monkeys challenged with pathogenic simian-human immunodeficiency virus. (United States)

    Manuel, Edwin R; Yeh, Wendy W; Seaman, Michael S; Furr, Kathryn; Lifton, Michelle A; Hulot, Sandrine L; Autissier, Patrick; Letvin, Norman L


    Emerging data suggest that a cytotoxic T-lymphocyte response against a diversity of epitopes confers greater protection against a human immunodeficiency virus/simian immunodeficiency virus infection than does a more focused response. To facilitate the creation of vaccine strategies that will generate cellular immune responses with the greatest breadth, it will be important to understand the mechanisms employed by the immune response to regulate the relative magnitudes of dominant and nondominant epitope-specific cellular immune responses. In this study, we generated dominant Gag p11C- and subdominant Env p41A-specific CD8(+) T-lymphocyte responses in Mamu-A*01(+) rhesus monkeys through vaccination with plasmid DNA and recombinant adenovirus encoding simian-human immunodeficiency virus (SHIV) proteins. Infection of vaccinated Mamu-A*01(+) rhesus monkeys with a SHIV Gag Deltap11C mutant virus generated a significantly increased expansion of the Env p41A-specific CD8(+) T-lymphocyte response in the absence of secondary Gag p11C-specific CD8(+) T-lymphocyte responses. These results indicate that the presence of the Gag p11C-specific CD8(+) T-lymphocyte response following virus challenge may exert suppressive effects on primed Env p41A-specific CD8(+) T-lymphocyte responses. These findings suggest that immunodomination exerted by dominant responses during SHIV infection may diminish the breadth of recall responses primed during vaccination.

  11. Epitope mapping of Ebola virus dominant and subdominant glycoprotein epitopes facilitates construction of an epitope-based DNA vaccine able to focus the antibody response in mice. (United States)

    Mitchell, Daniel A J; Dupuy, Lesley C; Sanchez-Lockhart, Mariano; Palacios, Gustavo; Back, Jaap W; Shimanovskaya, Katya; Chaudhury, Sidhartha; Ripoll, Daniel R; Wallqvist, Anders; Schmaljohn, Connie S


    We performed epitope mapping studies on the major surface glycoprotein (GP) of Ebola virus (EBOV) using Chemically Linked Peptides on Scaffolds (CLIPS), which form linear and potential conformational epitopes. This method identified monoclonal antibody epitopes and predicted additional epitopes recognized by antibodies in polyclonal sera from animals experimentally vaccinated against or infected with EBOV. Using the information obtained along with structural modeling to predict epitope accessibility, we then constructed two DNA vaccines encoding immunodominant and subdominant epitopes predicted to be accessible on EBOV GP. Although a construct designed to produce a membrane-bound oligopeptide was poorly immunogenic, a construct generating a secreted oligopeptide elicited strong antibody responses in mice. When this construct was administered as a boost to a DNA vaccine expressing the complete EBOV GP gene, the resultant antibody response was focused largely toward the less immunodominant epitopes in the oligopeptide. Taken together, the results of this work suggest a utility for this method for immune focusing of antibody responses elicited by vaccination.

  12. Multiplex peptide-MHC tetramer staining using mass cytometry for deep analysis of the influenza-specific T-cell response in mice. (United States)

    Fehlings, M; Chakarov, S; Simoni, Y; Sivasankar, B; Ginhoux, F; Newell, E W


    Antigen-specific T cells play a crucial role for the host protective immunity against viruses and other diseases. The use of mass cytometry together with a combinatorial multiplex tetramer staining has successfully been applied for probing and characterization of multiple antigen-specific CD8 + T cells in human blood samples. The present study shows that this approach can also be used to rapidly assess the magnitude of influenza-specific CD8 + T cell epitope dominance across lymph nodes and lungs in a murine model of a highly pathological influenza infection. Moreover, we show feasibility of extending this approach to include concurrent identification of virus-specific CD4 + T cells. By using a double coding approach, we probed for five influenza-specific MHCI-peptide complexes as well as one influenza-specific MHCII-peptide complex in the presence of irrelevant control peptides and show that this approach is capable of tracking antigen-specific T cells across individual lymph nodes and lungs. The simultaneous staining with 26 surface maker molecules further facilitated an in-depth characterization of T cells reacting with influenza epitopes and revealed tissue specific phenotypic differences between CD4 + T cells targeting the same pathogenic epitope. In conclusion, this approach provides the possibility for a rapid and comprehensive analysis of antigen-specific CD8 + and CD4 + T cells in different disease settings that might be advantageous for subsequent vaccine formulation strategies. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Enhancement of the CD8+ T cell response to a subdominant epitope of respiratory syncytial virus by deletion of an immunodominant epitope


    Mok, Hoyin; Lee, Sujin; Wright, David?W.; Crowe, James E.


    Cytotoxic T lymphocytes are critical for the control of respiratory syncytial virus infection in humans and mice. Recently, we identified a new H-2Kd restricted subdominant epitope in the RSV M2 protein. In this study, we investigated if modification of anchor residues at positions 2 and 9 in the dominant M282–90 epitope in the M2 protein would alter the CTL epitope dominance hierarchy following immunization with plasmid DNA encoding M2 proteins. We showed that immunogenicity of the subdomina...

  14. Immune subdominant antigens as vaccine candidates against Mycobacterium tuberculosis. (United States)

    Orr, Mark T; Ireton, Gregory C; Beebe, Elyse A; Huang, Po-Wei D; Reese, Valerie A; Argilla, David; Coler, Rhea N; Reed, Steven G


    Unlike most pathogens, many of the immunodominant epitopes from Mycobacterium tuberculosis are under purifying selection. This startling finding suggests that M. tuberculosis may gain an evolutionary advantage by focusing the human immune response against selected proteins. Although the implications of this to vaccine development are incompletely understood, it has been suggested that inducing strong Th1 responses against Ags that are only weakly recognized during natural infection may circumvent this evasion strategy and increase vaccine efficacy. To test the hypothesis that subdominant and/or weak M. tuberculosis Ags are viable vaccine candidates and to avoid complications because of differential immunodominance hierarchies in humans and experimental animals, we defined the immunodominance hierarchy of 84 recombinant M. tuberculosis proteins in experimentally infected mice. We then combined a subset of these dominant or subdominant Ags with a Th1 augmenting adjuvant, glucopyranosyl lipid adjuvant in stable emulsion, to assess their immunogenicity in M. tuberculosis-naive animals and protective efficacy as measured by a reduction in lung M. tuberculosis burden of infected animals after prophylactic vaccination. We observed little correlation between immunodominance during primary M. tuberculosis infection and vaccine efficacy, confirming the hypothesis that subdominant and weakly antigenic M. tuberculosis proteins are viable vaccine candidates. Finally, we developed two fusion proteins based on strongly protective subdominant fusion proteins. When paired with the glucopyranosyl lipid adjuvant in stable emulsion, these fusion proteins elicited robust Th1 responses and limited pulmonary M. tuberculosis for at least 6 wk postinfection with a single immunization. These findings expand the potential pool of M. tuberculosis proteins that can be considered as vaccine Ag candidates. Copyright © 2014 by The American Association of Immunologists, Inc.

  15. Stellarator Turbulence: Subdominant Eigenmodes and Quasilinear Modeling. (United States)

    Pueschel, M J; Faber, B J; Citrin, J; Hegna, C C; Terry, P W; Hatch, D R


    Owing to complex geometry, gyrokinetic simulations in stellarator geometry produce large numbers of subdominant unstable and stable, near-orthogonal eigenmodes. Here, results based on the full eigenmode spectrum in stellarator geometry are presented for the first time. In the nonlinear state of a low-magnetic-shear ion-temperature-gradient-driven case, a multitude of these modes are active and imprint the system. Turbulent frequency spectra are broadband as a consequence, in addition to a nonlinear, narrow signature at electron frequencies. It is shown that successful quasilinear, mixing-length transport modeling is possible in stellarators, where it is essential to account for all subdominant unstable modes.

  16. Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes

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    Román, Victor Raúl Gómez; Jensen, Kristoffer Jarlov; Jensen, Sanne Skov


    We have designed a therapeutic HIV-1 vaccine concept based on peptides together with the adjuvant CAF01. Peptides represented 15 HLA-supertype-restricted subdominant and conserved CD8 T cell epitopes and three CD4 T-helper cell epitopes. In this phase I clinical trial, safety and immunogenicity...... is feasible and safe in Guinea-Bissau and that it is possible to redirect T cell immunity with CAF01-adjuvanted HIV-1 peptide vaccine during untreated HIV-1 infection in some patients. However, relatively few preexisting and vaccine-induced HIV-1 T cell responses to CD8 T cell epitopes were detected against...

  17. A window of opportunity: Subdominant predators can use suboptimal prey. (United States)

    Jackson, Kelly A; McCord, Joshua S; White, Jennifer A


    Introduced species have been linked to declines of native species through mechanisms including intraguild predation and exploitative competition. However, coexistence among species may be promoted by niche partitioning if native species can use resources that the invasive species cannot. Previous research has shown that some strains of the aphid Aphis craccivora are toxic to a competitively dominant invasive lady beetle, Harmonia axyridis. Our objective was to investigate whether these aphids might be an exploitable resource for other, subdominant, lady beetle species. We compared larval development rate, survival, and adult weight of five lady beetle species in no-choice experiments with two different strains of A. craccivora, one of which is toxic to H. axyridis and one that is nontoxic. Two lady beetle species, Cycloneda munda and Coleomegilla maculata, were able to complete larval development when feeding on the aphid strain that is toxic to H. axyridis, experiencing only slight developmental delays relative to beetles feeding on the other aphid strain. One species, Coccinella septempunctata, also was able to complete larval development, but experienced a slight reduction in adult weight. The other two lady beetle species, Hippodamia convergens and Anatis labiculata, demonstrated generally low survivorship when consuming A. craccivora, regardless of aphid strain. All five species showed increased survival and/or development relative to H. axyridis on the "toxic" aphid strain. Our results suggest that this toxic trait may act as a narrow-spectrum defense for the aphids, providing protection against only some lady beetle enemies. For other less-susceptible lady beetles, these aphids have the potential to provide competitive release from the otherwise dominant H. axyridis.

  18. DNA/Ad5 vaccination with SIV epitopes induced epitope-specific CD4⁺ T cells, but few subdominant epitope-specific CD8⁺ T cells. (United States)

    Vojnov, Lara; Bean, Alexander T; Peterson, Eric J; Chiuchiolo, Maria J; Sacha, Jonah B; Denes, Ferencz S; Sandor, Matyas; Fuller, Deborah H; Fuller, James T; Parks, Christopher L; McDermott, Adrian B; Wilson, Nancy A; Watkins, David I


    The goals of a T cell-based vaccine for HIV are to reduce viral peak and setpoint and prevent transmission. While it has been relatively straightforward to induce CD8(+) T cell responses against immunodominant T cell epitopes, it has been more difficult to broaden the vaccine-induced CD8(+) T cell response against subdominant T cell epitopes. Additionally, vaccine regimens to induce CD4(+) T cell responses have been studied only in limited settings. In this study, we sought to elicit CD8(+) T cells against subdominant epitopes and CD4(+) T cells using various novel and well-established vaccine strategies. We vaccinated three Mamu-A*01(+) animals with five Mamu-A*01-restricted subdominant SIV-specific CD8(+) T cell epitopes. All three vaccinated animals made high frequency responses against the Mamu-A*01-restricted Env TL9 epitope with one animal making a low frequency CD8(+) T cell response against the Pol LV10 epitope. We also induced SIV-specific CD4(+) T cells against several MHC class II DRBw*606-restricted epitopes. Electroporated DNA with pIL-12 followed by a rAd5 boost was the most immunogenic vaccine strategy. We induced responses against all three Mamu-DRB*w606-restricted CD4 epitopes in the vaccine after the DNA prime. Ad5 vaccination further boosted these responses. Although we successfully elicited several robust epitope-specific CD4(+) T cell responses, vaccination with subdominant MHC class I epitopes elicited few detectable CD8(+) T cell responses. Broadening the CD8(+) T cell response against subdominant MHC class I epitopes was, therefore, more difficult than we initially anticipated. Copyright © 2011 Elsevier Ltd. All rights reserved.

  19. Adjuvanted HLA-supertype restricted subdominant peptides induce new T-cell immunity during untreated HIV-1-infection

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    Karlsson, Ingrid; Brandt, Lea; Vinner, Lasse


    We investigated the potential of inducing additional T-cell immunity during chronic HIV-1 infection directed to subdominant HIV-1 epitopes from common HLA-supertypes. Ten treatment-naïve HIV-1-infected individuals were immunized with peptides in the adjuvant CAF01. One individual received placebo...... responses specific for one or more vaccine epitopes were induced in 10/10 vaccinees. The responses were dominated by CD107a and MIP1β expression. There were no significant changes in HIV-1 viral load or CD4 T-cell counts. Our study demonstrates that the peptide/CAF01 vaccine is safe and that it is possible...... to generate new HIV-1 T-cell responses to defined epitopes in treatment-naïve HIV-1-infected individuals....

  20. Subdominant Outer Membrane Antigens in Anaplasma marginale: Conservation, Antigenicity, and Protective Capacity Using Recombinant Protein.

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    Deirdre R Ducken

    Full Text Available Anaplasma marginale is a tick-borne rickettsial pathogen of cattle with a worldwide distribution. Currently a safe and efficacious vaccine is unavailable. Outer membrane protein (OMP extracts or a defined surface protein complex reproducibly induce protective immunity. However, there are several knowledge gaps limiting progress in vaccine development. First, are these OMPs conserved among the diversity of A. marginale strains circulating in endemic regions? Second, are the most highly conserved outer membrane proteins in the immunogens recognized by immunized and protected animals? Lastly, can this subset of OMPs recognized by antibody from protected vaccinates and conserved among strains recapitulate the protection of outer membrane vaccines? To address the first goal, genes encoding OMPs AM202, AM368, AM854, AM936, AM1041, and AM1096, major subdominant components of the outer membrane, were cloned and sequenced from geographically diverse strains and isolates. AM202, AM936, AM854, and AM1096 share 99.9 to 100% amino acid identity. AM1041 has 97.1 to 100% and AM368 has 98.3 to 99.9% amino acid identity. While all four of the most highly conserved OMPs were recognized by IgG from animals immunized with outer membranes, linked surface protein complexes, or unlinked surface protein complexes and shown to be protected from challenge, the highest titers and consistent recognition among vaccinates were to AM854 and AM936. Consequently, animals were immunized with recombinant AM854 and AM936 and challenged. Recombinant vaccinates and purified outer membrane vaccinates had similar IgG and IgG2 responses to both proteins. However, the recombinant vaccinates developed higher bacteremia after challenge as compared to adjuvant-only controls and outer membrane vaccinates. These results provide the first evidence that vaccination with specific antigens may exacerbate disease. Progressing from the protective capacity of outer membrane formulations to

  1. Immediate effects of different treatments for the wrist joints of subdominant hands, using electromechanical reaction time. (United States)

    Hu, Chunying; Huang, Qiuchen; Yu, Lili; Zhou, Yue; Gu, Rui; Cui, Yao; Ge, Meng; Xu, Yanfeng; Liu, Jianfeng


    [Purpose] The aim of this study was to examine the immediate effects of muscle strength training and neuromuscular joint facilitation distal resistance training on wrist joints by using electromechanical reaction time. [Subjects and Methods] The subjects were 12 healthy young people (24.2 ± 3.1 years, 169.7 ± 6.5 cm, 65.3 ± 12.6 kg). Two kinds of isotonic contraction techniques were applied on the wrist joint: the wrist joint extension muscle strength training and the wrist joint extension pattern of neuromuscular joint facilitation. The electromechanical reaction time, premotor time, and motor time of the left upper limb were measured before and after each intervention session of muscle strength training and neuromuscular joint facilitation. [Results] The neuromuscular joint facilitation group showed significant shortening of the electromechanical reaction time and motor time after the intervention. [Conclusion] These results suggest that the electromechanical reaction time and motor time of the wrist joint can be improved by neuromuscular joint facilitation together with proximal resistance training, which can be used as a new form of exercise for improving the functions of subdominant hand wrist joints.

  2. [Age differences in memorizing of sequence of movements of leading and subdominant hand]. (United States)


    Age-specific features of motor short-term memory were studied. Two groups of right-handed volunteers (18-25 and 35-60 years old) reproduced the memorized sequence of six movements by the right hand or by the left one. The mean values of erroneous movements are shown to be significantly higher in elder group, demonstrating the age-dependent reduction of motor short-term memory capacity. More detailed analysis of reproduction of separate elements of the sequence demonstrates that the age-dependent increasing of error value is significant for the leading right hand, but not for the subdominant left one. The data obtained are consistent with the evidences about age-dependent reduction of hemispheric asymmetry and about more pronounced reduction of the accuracy of the movements of the leading hand. According to the hypothesis about hemispheric specialization in coding of movement information (right hemisphere specialization on absolute positional coding, the left one--on relative vector coding, i.e. coding of the movements) the data suppose the age-dependent reduction of the left-hemisphere system of relative coding. The reduction of memory capacity apparently can be explained by the reduction of role of the left hemisphere in functioning of the short-term motor memory owing to age-dependent reduction of hemispheric asymmetry.

  3. TCR Affinity Associated with Functional Differences between Dominant and Subdominant SIV Epitope-Specific CD8+ T Cells in Mamu-A*01+ Rhesus Monkeys


    Osuna, Christa E; Ana Maria Gonzalez; Hsun-Hsien Chang; Amy Shi Hung; Elizabeth Ehlinger; Kara Anasti; S Munir Alam; Letvin, Norman L.


    Many of the factors that contribute to CD8+ T cell immunodominance hierarchies during viral infection are known. However, the functional differences that exist between dominant and subdominant epitope-specific CD8+ T cells remain poorly understood. In this study, we characterized the phenotypic and functional differences between dominant and subdominant simian immunodeficiency virus (SIV) epitope-specific CD8+ T cells restricted by the major histocompatibility complex (MHC) class I allele Mam...

  4. Mucosal vaccination with heterologous viral vectored vaccine targeting subdominant SIV accessory antigens strongly inhibits early viral replication

    DEFF Research Database (Denmark)

    Xu, Huanbin; Andersson, Anne-Marie Carola; Ragonnaud, Emeline


    Conventional HIV T cell vaccine strategies have not been successful in containing acute peak viremia, nor in providing long-term control. We immunized rhesus macaques intramuscularly and rectally using a heterologous adenovirus vectored SIV vaccine regimen encoding normally weakly immunogenic tat...... immune hyperactivation as measured by naïve T cell depletion, Ki-67 and PD-1 expression on T cells. These results indicate that vaccination towards SIV accessory antigens vaccine can provide a level of acute control of SIV replication with a suggestion of beneficial immunological consequences in infected...... animals of unknown long-term significance. In conclusion, our studies demonstrate that a vaccine encoding subdominant antigens not normally associated with virus control can exert a significant impact on acute peak viremia....

  5. Kinetics of the avian influenza-specific humoral responses in lung are indicative of local antibody production

    NARCIS (Netherlands)

    Geus, de E.D.; Rebel, J.M.J.; Vervelde, L.


    The role and kinetics of respiratory immunoglobulins in AIV infection has not been investigated. In this study we determined the numbers of both total antibody secreting cells (ASC) and virus-specific ASC in lung, spleen, blood and bone marrow (BM) following low-pathogenic AIV infection. Antiviral

  6. Balancing Act: Evidence for a Strong Subdominant d-Wave Pairing Channel in Ba_{0.6}K_{0.4}Fe_{2}As_{2}

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    T. Böhm


    Full Text Available We present detailed measurements of the temperature-dependent Raman spectra of optimally doped Ba_{0.6}K_{0.4}Fe_{2}As_{2} and analyze the low-temperature spectra based on local-density-approximation band-structure calculations and the subsequent estimation of effective Raman vertices. Experimentally, a narrow, emergent mode appears in the B_{1g} (d_{x^{2}-y^{2}} Raman spectra only below T_{c}, well into the superconducting state and at an energy below twice the energy gap on the electron Fermi-surface sheets. The Raman spectra can be reproduced quantitatively with estimates for the magnitude and momentum-space structure of an A_{1g} (s-wave pairing gap on different Fermi-surface sheets, as well as the identification of the emergent sharp feature as a Bardasis-Schrieffer exciton. Formed as a Cooper-pair bound state in a subdominant d_{x^{2}-y^{2}} channel, the binding energy of the exciton relative to the gap edge shows that the coupling strength in the subdominant channel is as strong as 60% of that in the dominant s-wave channel. This result suggests that d_{x^{2}-y^{2}} may be the dominant pairing symmetry in Fe-based superconductors that lack central hole bands.

  7. Comparative prevalence and characterization of ESBL-producing Enterobacteriaceae in dominant versus subdominant enteric flora in veal calves at slaughterhouse, France. (United States)

    Haenni, Marisa; Châtre, Pierre; Métayer, Véronique; Bour, Maxime; Signol, Elodie; Madec, Jean-Yves; Gay, Emilie


    Food-producing animals have become a growing reservoir of Extended-Spectrum Beta-Lactamase (ESBL)-producing bacteria. In cattle, veal calves are exposed to high amounts of antibiotics but ESBL prevalence data are still limited compared to other food sectors such as poultry production. Based on the investigation of 491 veal calves from different slaughtering batches at 12 abattoirs, this study shows a prevalence of 29.4% of ESBL producers in the faecal flora of veal calves in France in 2012. A variety of blaCTX-M genes was found, reflecting possible diverse pathways of dissemination in cattle. Another major conclusion is the comparison of the ESBL prevalence in the dominant versus sub-dominant Escherichia coli population of the same calves (1% and 29.4%, respectively). Also, the ESBL E. coli clones in the sub-dominant flora mostly differed from the non-ESBL dominant E. coli clones of the same calves. Of note, the distribution of blaCTX-M genes and E. coli phylogroups were similar to the ones previously found in ESBL E. coli clones from diseased calves. The hypothesis that ESBL genes may distribute more abundantly in certain backgrounds of E. coli was also discussed. In all, as recently reported in the Netherlands, these results strongly suggest a recent increase in the prevalence of ESBL carriage in French veal calves, which should be considered one of the major ESBL reservoirs in food animals. Copyright © 2014 Elsevier B.V. All rights reserved.

  8. Influence of an immunodominant herpes simplex virus type 1 CD8+ T cell epitope on the target hierarchy and function of subdominant CD8+ T cells. (United States)

    Treat, Benjamin R; Bidula, Sarah M; Ramachandran, Srividya; St Leger, Anthony J; Hendricks, Robert L; Kinchington, Paul R


    Herpes simplex virus type 1 (HSV-1) latency in sensory ganglia such as trigeminal ganglia (TG) is associated with a persistent immune infiltrate that includes effector memory CD8+ T cells that can influence HSV-1 reactivation. In C57BL/6 mice, HSV-1 induces a highly skewed CD8+ T cell repertoire, in which half of CD8+ T cells (gB-CD8s) recognize a single epitope on glycoprotein B (gB498-505), while the remainder (non-gB-CD8s) recognize, in varying proportions, 19 subdominant epitopes on 12 viral proteins. The gB-CD8s remain functional in TG throughout latency, while non-gB-CD8s exhibit varying degrees of functional compromise. To understand how dominance hierarchies relate to CD8+ T cell function during latency, we characterized the TG-associated CD8+ T cells following corneal infection with a recombinant HSV-1 lacking the immunodominant gB498-505 epitope (S1L). S1L induced a numerically equivalent CD8+ T cell infiltrate in the TG that was HSV-specific, but lacked specificity for gB498-505. Instead, there was a general increase of non-gB-CD8s with specific subdominant epitopes arising to codominance. In a latent S1L infection, non-gB-CD8s in the TG showed a hierarchy targeting different epitopes at latency compared to at acute times, and these cells retained an increased functionality at latency. In a latent S1L infection, these non-gB-CD8s also display an equivalent ability to block HSV reactivation in ex vivo ganglionic cultures compared to TG infected with wild type HSV-1. These data indicate that loss of the immunodominant gB498-505 epitope alters the dominance hierarchy and reduces functional compromise of CD8+ T cells specific for subdominant HSV-1 epitopes during viral latency.

  9. Influence of an immunodominant herpes simplex virus type 1 CD8+ T cell epitope on the target hierarchy and function of subdominant CD8+ T cells.

    Directory of Open Access Journals (Sweden)

    Benjamin R Treat


    Full Text Available Herpes simplex virus type 1 (HSV-1 latency in sensory ganglia such as trigeminal ganglia (TG is associated with a persistent immune infiltrate that includes effector memory CD8+ T cells that can influence HSV-1 reactivation. In C57BL/6 mice, HSV-1 induces a highly skewed CD8+ T cell repertoire, in which half of CD8+ T cells (gB-CD8s recognize a single epitope on glycoprotein B (gB498-505, while the remainder (non-gB-CD8s recognize, in varying proportions, 19 subdominant epitopes on 12 viral proteins. The gB-CD8s remain functional in TG throughout latency, while non-gB-CD8s exhibit varying degrees of functional compromise. To understand how dominance hierarchies relate to CD8+ T cell function during latency, we characterized the TG-associated CD8+ T cells following corneal infection with a recombinant HSV-1 lacking the immunodominant gB498-505 epitope (S1L. S1L induced a numerically equivalent CD8+ T cell infiltrate in the TG that was HSV-specific, but lacked specificity for gB498-505. Instead, there was a general increase of non-gB-CD8s with specific subdominant epitopes arising to codominance. In a latent S1L infection, non-gB-CD8s in the TG showed a hierarchy targeting different epitopes at latency compared to at acute times, and these cells retained an increased functionality at latency. In a latent S1L infection, these non-gB-CD8s also display an equivalent ability to block HSV reactivation in ex vivo ganglionic cultures compared to TG infected with wild type HSV-1. These data indicate that loss of the immunodominant gB498-505 epitope alters the dominance hierarchy and reduces functional compromise of CD8+ T cells specific for subdominant HSV-1 epitopes during viral latency.

  10. In vivo proliferation of naïve and memory influenza-specific CD8(+) T cells

    DEFF Research Database (Denmark)

    Flynn, K J; Riberdy, J M; Christensen, Jan Pravsgaard


    days. The greatly expanded population of CD8(+)NPP(+) memory T cells in the lymphoid tissue of secondarily challenged mice declines progressively in mean prevalence over the ensuing 100 days, despite the fact that at least some of these lymphocytes continue to cycle. The recall of cell......The virus-specific CD8(+) T cell response has been analyzed through the development, effector, and recovery phases of primary and secondary influenza pneumonia. Apparently, most, if not all, memory T cells expressing clonotypic receptors that bind a tetrameric complex of influenza nucleoprotein (NP......)(366-374) peptide+H-2D(b) (NPP) are induced to divide during the course of this localized respiratory infection. The replicative phase of the recall response ends about the time that virus can no longer be recovered from the lung, whereas some primary CD8(+)NPP(+) T cells may proliferate for a few more...

  11. A self-consistent model of cosmic-ray fluxes and positron excess: roles of nearby pulsars and a sub-dominant source population (United States)

    Joshi, Jagdish C.; Razzaque, Soebur


    The cosmic-ray positron flux calculated using the cosmic-ray nuclei interactions in our Galaxy cannot explain observed data above 10 GeV. An excess in the measured positron flux is therefore open to interpretation. Nearby pulsars, located within sub-kiloparsec range of the Solar system, are often invoked as plausible sources contributing to the excess. We show that an additional, sub-dominant population of sources together with the contributions from a few nearby pulsars can explain the latest positron excess data from the Alpha Magnetic Spectrometer (AMS). We simultaneously model, using the DRAGON code, propagation of cosmic-ray proton, Helium, electron and positron and fit their respective flux data. Our fit to the Boron to Carbon ratio data gives a diffusion spectral index of 0.45, which is close to the Kraichnan turbulent spectrum.

  12. Identification of conserved subdominant HIV Type 1 CD8(+) T Cell epitopes restricted within common HLA Supertypes for therapeutic HIV Type 1 vaccines

    DEFF Research Database (Denmark)

    Karlsson, Ingrid; Kløverpris, Henrik; Jensen, Kristoffer Jarlov


    The high HIV-1 prevalence, up to 4.6% in Guinea-Bissau, West Africa, makes it a relevant location for testing of therapeutic vaccines. With the aim of performing a clinical study in Guinea-Bissau, after first testing the vaccine for safety in Denmark, Europe, we here describe the design...... of a universal epitope peptide-based T cell vaccine with relevance for any geographic locations. The two major obstacles when designing such a vaccine are the high diversities of the HIV-1 genome and of the human major histocompatibility complex (MHC) class I. We selected 15 CD8-restricted epitopes predicted...... from conserved regions of HIV-1 that were subdominant (i.e., infrequently targeted) within natural infections. Moreover, the epitopes were predicted to be restricted to at least one of the five common HLA supertypes (HLA-A01, A02, A03, B07, and B44). Here, we validated the resulting peptide...

  13. Influenza preparedness and response: Involvement of African Field Epidemiology and Laboratory Training Programs, 2009

    Directory of Open Access Journals (Sweden)

    Nykiconia Preacely


    Full Text Available st pandemic preparedness and response exercise, five (83% of them were influenza specific. CONCLUSION: FELTPs played an important role in H1N1 surveillance and response in sub-Saharan Africa. Continued technical assistance and support to these programs is vital to foster their capacity to monitor and control public health threats.

  14. Comparison of mucosal lining fluid sampling methods and influenza-specific IgA detection assays for use in human studies of influenza immunity. (United States)

    de Silva, Thushan I; Gould, Victoria; Mohammed, Nuredin I; Cope, Alethea; Meijer, Adam; Zutt, Ilse; Reimerink, Johan; Kampmann, Beate; Hoschler, Katja; Zambon, Maria; Tregoning, John S


    We need greater understanding of the mechanisms underlying protection against influenza virus to develop more effective vaccines. To do this, we need better, more reproducible methods of sampling the nasal mucosa. The aim of the current study was to compare levels of influenza virus A subtype-specific IgA collected using three different methods of nasal sampling. Samples were collected from healthy adult volunteers before and after LAIV immunization by nasal wash, flocked swabs and Synthetic Absorptive Matrix (SAM) strips. Influenza A virus subtype-specific IgA levels were measured by haemagglutinin binding ELISA or haemagglutinin binding microarray and the functional response was assessed by microneutralization. Nasosorption using SAM strips lead to the recovery of a more concentrated sample of material, with a significantly higher level of total and influenza H1-specific IgA. However, an equivalent percentage of specific IgA was observed with all sampling methods when normalized to the total IgA. Responses measured using a recently developed antibody microarray platform, which allows evaluation of binding to multiple influenza strains simultaneously with small sample volumes, were compared to ELISA. There was a good correlation between ELISA and microarray values. Material recovered from SAM strips was weakly neutralizing when used in an in vitro assay, with a modest correlation between the level of IgA measured by ELISA and neutralization, but a greater correlation between microarray-measured IgA and neutralizing activity. In conclusion we have tested three different methods of nasal sampling and show that flocked swabs and novel SAM strips are appropriate alternatives to traditional nasal washes for assessment of mucosal influenza humoral immunity. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. The in vivo effects of neutralizing antibodies against IFN-γ, IL-4, or IL-10 on the humoral immune response in young and aged mice

    NARCIS (Netherlands)

    Dobber, R.; Tielemans, M.; Nagelkerken, L.


    In the present study we investigated whether age-related changes in the composition and functional properties of murine CD4+ T cells are reflected in vivo by a changed humoral response to influenza vaccine in aged mice. After the primary immunization, the titers of influenza-specific IgM, IgG1,

  16. Preserved antigen-specific immune response in patients with multiple sclerosis responding to IFNβ-therapy.

    Directory of Open Access Journals (Sweden)

    Matthias Mehling

    Full Text Available BACKGROUND: Interferon-beta (IFNβ regulates the expression of a complex set of pro- as well as anti-inflammatory genes. In cohorts of MS patients unstratified for therapeutic response to IFNβ, normal vaccine-specific immune responses have been observed. Data capturing antigen-specific immune responses in cohorts of subjects defined by response to IFNβ-therapy are not available. OBJECTIVE: To assess antigen-specific immune responses in a cohort of MS patients responding clinically and radiologically to IFNβ. METHODS: In 26 MS patients, clinical and MRI disease activity were assessed before and under treatment with IFNβ. Humoral and cellular immune response to influenza vaccine was prospectively characterized in these individuals, and 33 healthy controls by influenza-specific Enzyme-Linked Immunosorbent Assay (ELISA and Enzyme Linked Immuno Spot Technique (ELISPOT. RESULTS: Related to pre-treatment disease activity, IFNβ reduced clinical and radiological MS disease-activity. Following influenza vaccination, frequencies of influenza-specific T cells and concentrations of anti-influenza A and B IgM and IgG increased comparably in MS-patients and in healthy controls. CONCLUSIONS: By showing in a cohort of MS-patients responding to IFNβ vaccine-specific immune responses comparable to controls, this study indicates that antigen-specific immune responses can be preserved under successful IFNβ-therapy.

  17. High Affinity Antibodies against Influenza Characterize the Plasmablast Response in SLE Patients After Vaccination. (United States)

    Kaur, Kaval; Zheng, Nai-Ying; Smith, Kenneth; Huang, Min; Li, Lie; Pauli, Noel T; Henry Dunand, Carole J; Lee, Jane-Hwei; Morrissey, Michael; Wu, Yixuan; Joachims, Michelle L; Munroe, Melissa E; Lau, Denise; Qu, Xinyan; Krammer, Florian; Wrammert, Jens; Palese, Peter; Ahmed, Rafi; James, Judith A; Wilson, Patrick C


    Breakdown of B cell tolerance is a cardinal feature of systemic lupus erythematosus (SLE). Increased numbers of autoreactive mature naïve B cells have been described in SLE patients and autoantibodies have been shown to arise from autoreactive and non-autoreactive precursors. How these defects, in the regulation of B cell tolerance and selection, influence germinal center (GC) reactions that are directed towards foreign antigens has yet to be investigated. Here, we examined the characteristics of post-GC foreign antigen-specific B cells from SLE patients and healthy controls by analyzing monoclonal antibodies generated from plasmablasts induced specifically by influenza vaccination. We report that many of the SLE patients had anti-influenza antibodies with higher binding affinity and neutralization capacity than those from controls. Although overall frequencies of autoreactivity in the influenza-specific plasmablasts were similar for SLE patients and controls, the variable gene repertoire of influenza-specific plasmablasts from SLE patients was altered, with increased usage of JH6 and long heavy chain CDR3 segments. We found that high affinity anti-influenza antibodies generally characterize the plasmablast responses of SLE patients with low levels of autoreactivity; however, certain exceptions were noted. The high-avidity antibody responses in SLE patients may also be correlated with cytokines that are abnormally expressed in lupus. These findings provide insights into the effects of dysregulated immunity on the quality of antibody responses following influenza vaccination and further our understanding of the underlying abnormalities of lupus.

  18. High Affinity Antibodies against Influenza Characterize the Plasmablast Response in SLE Patients After Vaccination.

    Directory of Open Access Journals (Sweden)

    Kaval Kaur

    Full Text Available Breakdown of B cell tolerance is a cardinal feature of systemic lupus erythematosus (SLE. Increased numbers of autoreactive mature naïve B cells have been described in SLE patients and autoantibodies have been shown to arise from autoreactive and non-autoreactive precursors. How these defects, in the regulation of B cell tolerance and selection, influence germinal center (GC reactions that are directed towards foreign antigens has yet to be investigated. Here, we examined the characteristics of post-GC foreign antigen-specific B cells from SLE patients and healthy controls by analyzing monoclonal antibodies generated from plasmablasts induced specifically by influenza vaccination. We report that many of the SLE patients had anti-influenza antibodies with higher binding affinity and neutralization capacity than those from controls. Although overall frequencies of autoreactivity in the influenza-specific plasmablasts were similar for SLE patients and controls, the variable gene repertoire of influenza-specific plasmablasts from SLE patients was altered, with increased usage of JH6 and long heavy chain CDR3 segments. We found that high affinity anti-influenza antibodies generally characterize the plasmablast responses of SLE patients with low levels of autoreactivity; however, certain exceptions were noted. The high-avidity antibody responses in SLE patients may also be correlated with cytokines that are abnormally expressed in lupus. These findings provide insights into the effects of dysregulated immunity on the quality of antibody responses following influenza vaccination and further our understanding of the underlying abnormalities of lupus.

  19. Critical role of TLR7 signaling in the priming of cross-protective cytotoxic T lymphocyte responses by a whole inactivated influenza virus vaccine.

    Directory of Open Access Journals (Sweden)

    Natalija Budimir

    Full Text Available Current influenza vaccines fail to induce protection against antigenically distinct virus strains. Accordingly, there is a need for the development of cross-protective vaccines. Previously, we and others have shown that vaccination with whole inactivated virus (WIV induces cross-protective cellular immunity in mice. To probe the mechanistic basis for this finding, we investigated the role of TLR7, a receptor for single-stranded RNA, in induction of cross-protection. Vaccination of TLR7-/- mice with influenza WIV failed to protect against a lethal heterosubtypic challenge; in contrast, wild-type mice were fully protected. The lack of protection in TLR7-/- mice was associated with high viral load and a relative paucity of influenza-specific CD8+ cytotoxic T lymphocyte (CTL responses. Dendritic cells (DCs from TLR7-/- mice were unable to cross-present WIV-derived antigen to influenza-specific CTLs in vitro. Similarly, TLR7-/- DCs failed to mature and become activated in response to WIV, as determined by the assessment of surface marker expression and cytokine production. Plasmacytoid DCs (pDCs derived from wild-type mice responded directly to WIV while purified conventional DCs (cDCs did not respond to WIV in isolation, but were responsive in mixed pDC/cDC cultures. Depletion of pDCs prior to and during WIV immunization resulted in reduced numbers of influenza-specific CTLs and impaired protection from heterosubtypic challenge. Thus, TLR7 plays a critical role in the induction of cross-protective immunity upon vaccination with WIV. The initial target cells for WIV appear to be pDCs which by direct or indirect mechanisms promote activation of robust CTL responses against conserved influenza epitopes.

  20. CD4+ T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8+ T cell responses to influenza. (United States)

    Ballesteros-Tato, André; León, Beatriz; Lund, Frances E; Randall, Troy D


    CD4(+) T cells promote CD8(+) T cell priming by licensing dendritic cells (DCs) via CD40-CD154 interactions. However, the initial requirement for CD40 signaling may be replaced by the direct activation of DCs by pathogen-derived signals. Nevertheless, CD40-CD154 interactions are often required for optimal CD8(+) T cell responses to pathogens for unknown reasons. Here we show that CD40 signaling is required to prevent the premature contraction of the influenza-specific CD8(+) T cell response. CD40 is required on DCs but not on B cells or T cells, whereas CD154 is required on CD4(+) T cells but not CD8(+) T cells, NKT cells, or DCs. Paradoxically, even though CD154-expressing CD4(+) T cells are required for robust CD8(+) T cell responses, primary CD8(+) T cell responses are apparently normal in the absence of CD4(+) T cells. We resolved this paradox by showing that the interaction of CD40-bearing DCs with CD154-expressing CD4(+) T cells precludes regulatory T cell (T reg cell)-mediated suppression and prevents premature contraction of the influenza-specific CD8(+) T cell response. Thus, CD4(+) T helper cells are not required for robust CD8(+) T cell responses to influenza when T reg cells are absent.

  1. Identification of subdominant lactic acid bacteria in dawadawa (a ...

    African Journals Online (AJOL)

    Pediococcus sp, Lactobacillus sp, Lactobacillus plantarum, Lactobacillus acidophilus and Lactobacillus brevis. The first dominant species were P. pentosaceus, which was more in abundance, L. raffinolactus, L. mesenteroides and another Leuconostoc sp. At the end of fermentation, a stable community comprising of P.

  2. CD4+ T helper cells use CD154–CD40 interactions to counteract T reg cell–mediated suppression of CD8+ T cell responses to influenza (United States)

    Ballesteros-Tato, André; León, Beatriz; Lund, Frances E.


    CD4+ T cells promote CD8+ T cell priming by licensing dendritic cells (DCs) via CD40–CD154 interactions. However, the initial requirement for CD40 signaling may be replaced by the direct activation of DCs by pathogen-derived signals. Nevertheless, CD40–CD154 interactions are often required for optimal CD8+ T cell responses to pathogens for unknown reasons. Here we show that CD40 signaling is required to prevent the premature contraction of the influenza-specific CD8+ T cell response. CD40 is required on DCs but not on B cells or T cells, whereas CD154 is required on CD4+ T cells but not CD8+ T cells, NKT cells, or DCs. Paradoxically, even though CD154-expressing CD4+ T cells are required for robust CD8+ T cell responses, primary CD8+ T cell responses are apparently normal in the absence of CD4+ T cells. We resolved this paradox by showing that the interaction of CD40-bearing DCs with CD154-expressing CD4+ T cells precludes regulatory T cell (T reg cell)–mediated suppression and prevents premature contraction of the influenza-specific CD8+ T cell response. Thus, CD4+ T helper cells are not required for robust CD8+ T cell responses to influenza when T reg cells are absent. PMID:23835849

  3. US university response to H1N1: a study of access to online preparedness and response information. (United States)

    Schwartz, Rachel D; Bayles, Brett R


    The recent outbreaks of severe acute respiratory syndrome, H5N1 (avian influenza), and, most recently, the novel H1N1 influenza pandemic of 2009 have raised awareness of the danger of new and emerging infections. Preparedness and response plans for such outbreaks are crucial, and given the centrality of the Internet as a source of information on university and college campuses, such plans should be made available at pandemic-dedicated university Web sites. The information on these sites must be comprehensive, accessible, and tailored to the specific circumstances of individual schools. An Internet-based search was conducted in September 2009 to evaluate university Web sites for influenza-specific information in a sample of 51 universities. Web sites were assessed by applying a set of key words and a list of 10 indicators used as measures of accessibility and comprehensiveness. Of the 51 universities evaluated, only 9 (17.6%) either had no influenza Web site or had a university influenza preparedness plan with no dedicated Web site. Only 6 (14.3%) of the schools with influenza specific Web sites had information for parents, with 23 (54.8%) providing information specifically for faculty and staff, and 24 (57.1%) providing information specifically to students. We found no guidelines for maximizing the access to and effectiveness of online pandemic communications at institutions of higher learning. Until such time as appropriate guidelines are developed, university authorities must carefully assess their needs, taking into account local, national, and international public health circumstances and resources; ease of access; comprehensiveness; and appropriately tailored strategies in their online communications. Copyright © 2012 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.

  4. Antibody Responses with Fc-Mediated Functions after Vaccination of HIV-Infected Subjects with Trivalent Influenza Vaccine

    DEFF Research Database (Denmark)

    Kristensen, Anne B; Lay, William N; Ana-Sosa-Batiz, Fernanda


    This study seeks to assess the ability of seasonal trivalent inactivated influenza vaccine (TIV) to induce nonneutralizing antibodies (Abs) with Fc-mediated functions in HIV-uninfected and HIV-infected subjects. Functional influenza-specific Ab responses were studied in 30 HIV-negative and 27 HIV......-positive subjects immunized against seasonal influenza. All 57 subjects received the 2015 TIV. Fc-mediated antihemagglutinin (anti-HA) Ab activity was measured in plasma before and 4 weeks after vaccination using Fc-receptor-binding assays, NK cell activation assays, and phagocytosis assays. At baseline, the HIV......-positive group had detectable but reduced functional Ab responses to both vaccine and nonvaccine influenza antigens. TIV enhanced Fc-mediated Ab responses in both HIV-positive and HIV-negative groups. A larger rise was generally observed in the HIV-positive group, such that there was no difference in functional...

  5. The impact of immunosenescence on humoral immune response variation after influenza A/H1N1 vaccination in older subjects.

    Directory of Open Access Journals (Sweden)

    Iana H Haralambieva

    Full Text Available Although influenza causes significant morbidity and mortality in the elderly, the factors underlying the reduced vaccine immunogenicity and efficacy in this age group are not completely understood. Age and immunosenescence factors, and their impact on humoral immunity after influenza vaccination, are of growing interest for the development of better vaccines for the elderly.We assessed associations between age and immunosenescence markers (T cell receptor rearrangement excision circles - TREC content, peripheral white blood cell telomerase - TERT expression and CD28 expression on T cells and influenza A/H1N1 vaccine-induced measures of humoral immunity in 106 older subjects at baseline and three timepoints post-vaccination.TERT activity (TERT mRNA expression was significantly positively correlated with the observed increase in the influenza-specific memory B cell ELISPOT response at Day 28 compared to baseline (p-value=0.025. TREC levels were positively correlated with the baseline and early (Day 3 influenza A/H1N1-specific memory B cell ELISPOT response (p-value=0.042 and p-value=0.035, respectively. The expression and/or expression change of CD28 on CD4+ and/or CD8+ T cells at baseline and Day 3 was positively correlated with the influenza A/H1N1-specific memory B cell ELISPOT response at baseline, Day 28 and Day 75 post-vaccination. In a multivariable analysis, the peak antibody response (HAI and/or VNA at Day 28 was negatively associated with age, the percentage of CD8+CD28 low T cells, IgD+CD27- naïve B cells, and percentage overall CD20- B cells and plasmablasts, measured at Day 3 post-vaccination. The early change in influenza-specific memory B cell ELISPOT response was positively correlated with the observed increase in influenza A/H1N1-specific HAI antibodies at Day 28 and Day 75 relative to baseline (p-value=0.007 and p-value=0.005, respectively.Our data suggest that influenza-specific humoral immunity is significantly influenced by

  6. Plasmablast-derived polyclonal antibody response after influenza vaccination. (United States)

    He, Xiao-Song; Sasaki, Sanae; Narvaez, Carlos F; Zhang, Caiqiu; Liu, Hui; Woo, Jennifer C; Kemble, George W; Dekker, Cornelia L; Davis, Mark M; Greenberg, Harry B


    Conventional measurement of antibody responses to vaccines largely relies on serum antibodies, which are primarily produced by bone marrow plasma cells and may not represent the entire vaccine-induced B cell repertoire, including important functional components such as those targeted to mucosal sites. After immunization or infection, activated B cells differentiate into plasmablasts in local lymphoid organs, then traffic through circulation to the target sites where they further develop into plasma cells. On day 7 after influenza vaccination, a burst of plasmablasts, highly enriched for vaccine-specific antibody secreting cells, appears in the peripheral blood. This provides a unique window to the overall B cell response to the vaccine, without interference of pre-existing cross-reactive serum antibody. In this study we isolated B cells from volunteers on day 7 after immunization with the inactivated influenza vaccine and cultured them ex vivo to collect plasmablast-derived polyclonal antibodies (PPAb). The PPAb contained secreted IgG and IgA, which was approximately 0.2ng per antibody secreting cell. Influenza-specific IgG and IgA binding activity was detected in PPAb at dilutions up to 10(5) by ELISA. The ratio of the titers of influenza-specific IgA to IgG by ELISA was 4-fold higher in PPAb than in day 28 post-vaccination sera, suggesting that vaccine-induced IgA is enriched in PPAb compared to sera. Functional activity was also detected in PPAb as determined by microneutralization and hemagglutination inhibition assays. In addition to bulk B cell cultures, we also cultured plasmablast subsets sorted by cell surface markers to generate PPAb. These results suggest that PPAb better reflects the mucosal IgA response than serum samples. Since PPAb are exclusively produced by recently activated B cells, it allows assessing vaccine-induced antibody response without interference from pre-existing cross-reactive serum antibodies and permits an assessment of antibody

  7. HLA Class I Binding 9mer Peptides from Influenza A Virus Induce CD4(+) T Cell Responses

    DEFF Research Database (Denmark)

    Wang, M. J.; Larsen, Mette Voldby; Nielsen, Morten


    Background: Identification of human leukocyte antigen class I (HLA-I) restricted cytotoxic T cell (CTL) epitopes from influenza virus is of importance for the development of new effective peptide-based vaccines. Methodology/Principal Findings: In the present work, bioinformatics was used to predict...... 9mer peptides derived from available influenza A viral proteins with binding affinity for at least one of the 12 HLA-I supertypes. The predicted peptides were then selected in a way that ensured maximal coverage of the available influenza A strains. One hundred and thirty one peptides were...... synthesized and their binding affinities for the HLA-I supertypes were measured in a biochemical assay. Influenza-specific T cell responses towards the peptides were quantified using IFN gamma ELISPOT assays with peripheral blood mononuclear cells (PBMC) from adult healthy HLA-I typed donors as responder...

  8. CAF01 potentiates immune responses and efficacy of an inactivated influenza vaccine in ferrets.

    Directory of Open Access Journals (Sweden)

    Cyril Jean-Marie Martel

    Full Text Available Trivalent inactivated vaccines (TIV against influenza are given to 350 million people every year. Most of these are non-adjuvanted vaccines whose immunogenicity and protective efficacy are considered suboptimal. Commercially available non-adjuvanted TIV are known to elicit mainly a humoral immune response, whereas the induction of cell-mediated immune responses is negligible. Recently, a cationic liposomal adjuvant (dimethyldioctadecylammonium/trehalose 6,6'-dibehenate, CAF01 was developed. CAF01 has proven to enhance both humoral and cell-mediated immune responses to a number of different experimental vaccine candidates. In this study, we compared the immune responses in ferrets to a commercially available TIV with the responses to the same vaccine mixed with the CAF01 adjuvant. Two recently circulating H1N1 viruses were used as challenge to test the vaccine efficacy. CAF01 improved the immunogenicity of the vaccine, with increased influenza-specific IgA and IgG levels. Additionally, CAF01 promoted cellular-mediated immunity as indicated by interferon-gamma expressing lymphocytes, measured by flow cytometry. CAF01 also enhanced the protection conferred by the vaccine by reducing the viral load measured in nasal washes by RT-PCR. Finally, CAF01 allowed for dose-reduction and led to higher levels of protection compared to TIV adjuvanted with a squalene emulsion. The data obtained in this human-relevant challenge model supports the potential of CAF01 in future influenza vaccines.

  9. Enhanced transpiration by riparian buffer trees in response to advection in a humid temperate agricultural landscape (United States)

    Hernandez-Santana, V.; Asbjornsen, H.; Sauer, T.; Isenhart, T.; Schilling, K.; Schultz, Ronald


    Riparian buffers are designed as management practices to increase infiltration and reduce surface runoff and transport of sediment and nonpoint source pollutants from crop fields to adjacent streams. Achieving these ecosystem service goals depends, in part, on their ability to remove water from the soil via transpiration. In these systems, edges between crop fields and trees of the buffer systems can create advection processes, which could influence water use by trees. We conducted a field study in a riparian buffer system established in 1994 under a humid temperate climate, located in the Corn Belt region of the Midwestern U.S. (Iowa). The goals were to estimate stand level transpiration by the riparian buffer, quantify the controls on water use by the buffer system, and determine to what extent advective energy and tree position within the buffer system influence individual tree transpiration rates. We primarily focused on the water use response (determined with the Heat Ratio Method) of one of the dominant species (Acer saccharinum) and a subdominant (Juglans nigra). A few individuals of three additional species (Quercus bicolor, Betula nigra, Platanus occidentalis) were monitored over a shorter time period to assess the generality of responses. Meteorological stations were installed along a transect across the riparian buffer to determine the microclimate conditions. The differences found among individuals were attributed to differences in species sap velocities and sapwood depths, location relative to the forest edge and prevailing winds and canopy exposure and dominance. Sapflow rates for A. saccharinum trees growing at the SE edge (prevailing winds) were 39% greater than SE interior trees and 30% and 69% greater than NW interior and edge trees, respectively. No transpiration enhancement due to edge effect was detected in the subdominant J. nigra. The results were interpreted as indicative of advection effects from the surrounding crops. Further, significant

  10. Development of cross-protective influenza A vaccines based on cellular responses

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    Peter Christiaan Soema


    Full Text Available Seasonal influenza vaccines provide protection against matching influenza A virus (IAV strains mainly through the induction of neutralizing serum IgG antibodies. However, these antibodies fail to confer a protective effect against mismatched IAV. This lack of efficacy against heterologous influenza strains has spurred the vaccine development community to look for other influenza vaccine concepts, which have the ability to elicit cross-protective immune responses.One of the concepts that is currently been worked on are influenza vaccines inducing influenza-specific T cell responses. T cells are able to lyse infected host cells, thereby clearing the virus. More interestingly, these T cells can recognize highly conserved epitopes of internal influenza proteins, making cellular responses less vulnerable to antigenic variability. T cells are therefore cross-reactive against many influenza strains, and thus are a promising concept for future influenza vaccines. Despite their potential, there are currently no T cell based IAV vaccines on the market. Selection of the proper antigen, appropriate vaccine formulation and evaluation of the efficacy of T cell vaccines remains challenging, both in preclinical and clinical settings.In this review, we will discuss the current developments in influenza T cell vaccines, focusing on existing protein-based and novel peptide-based vaccine formulations. Furthermore, we will discuss the feasibility of influenza T cell vaccines and their possible use in the future.

  11. A De-O-acylated Lipooligosaccharide-Based Adjuvant System Promotes Antibody and Th1-Type Immune Responses to H1N1 Pandemic Influenza Vaccine in Mice

    Directory of Open Access Journals (Sweden)

    Ji In Ryu


    Full Text Available Vaccine adjuvants are agents that are used to promote immune responses to vaccine antigens and thereby to enhance the protective efficacy of the vaccines. In this study, we investigated the adjuvant activity of CIA06, an adjuvant system that is composed of a toll-like receptor 4 agonist de-O-acylated lipooligosaccharide (dLOS and aluminum hydroxide, on the H1N1 pandemic influenza vaccine Greenflu-S® in mice. CIA06 significantly enhanced influenza-specific serum IgG, hemagglutination-inhibition, and virus-neutralizing antibody titers, which eliminated vaccine dose-dependency in the antibody response. Mice immunized with the CIA06-adjuvanted Greenflu-S showed Th1-type-predominant cytokine profiles, and both CD4+ and CD8+ T cell responses were induced. Immunization of mice with the CIA06-adjuvanted vaccine reduced the mortality and morbidity of mice upon lethal challenges with influenza virus, and no excessive inflammatory responses were observed in the lung tissues of the immunized mice after viral infection. These data suggest that the dLOS-based adjuvant system CIA06 can be used to promote the immune responses to influenza vaccine or to spare antigen dose without causing harmful inflammatory responses.

  12. Subdominant positive solutions of the discrete equation Δu(k+n=−p(ku(k

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    Jaromír Baštinec


    Full Text Available A delayed discrete equation Δu(k+n=−p(ku(k with positive coefficient p is considered. Sufficient conditions with respect to p are formulated in order to guarantee the existence of positive solutions if k→∞. As a tool of the proof of corresponding result, the method described in the author's previous papers is used. Except for the fact of the existence of positive solutions, their upper estimation is given. The analysis shows that every positive solution of the indicated family of positive solutions tends to zero (if k→∞ with the speednot smaller than the speed characterized by the function k·(n/(n+1k. A comparison with the known results is given and some open questions are discussed.

  13. Social dominance is associated with individual differences in heart rate and energetic response to food restriction in female red deer. (United States)

    Turbill, Christopher; Ruf, Thomas; Rothmann, Angela; Arnold, Walter


    Energy expenditure is a key mechanism underlying animal ecology, yet why individuals often differ in metabolic rate even under identical conditions remains largely unexplained. Individual variation in metabolism might be explained by correlations with other behavioral and physiological traits, with individual syndromes having environment- or state-dependent costs and benefits to fitness. We tested whether social rank within herds of female red deer is associated with individual differences in resting heart rate, an index of metabolic rate, and energetic response to monthly periods of food restriction during winter in a large outdoor enclosure near Vienna, Austria. Social rank had a strong positive effect on average daily heart rate, independent of the effects of food intake, air temperature, body temperature, and body mass. Subordinate individuals had lower heart rates than dominants, and consequently they suffered lower rates of body mass loss during periods of restricted pellet food supply. A greater capacity to minimize energy requirements might benefit the survival of subdominant female red deer during periods of negative energy balance in winter. Our study provides empirical support in a large mammal for linkages in behavior and metabolism within individuals that have environment-dependent consequences to the energy budget.

  14. Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8+ T Cell Responses

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    Monica Loi


    Full Text Available The macroautophagy machinery has been implicated in MHC class II restricted antigen presentation. Here, we report that this machinery assists in the internalization of MHC class I molecules. In the absence of the autophagy factors Atg5 and Atg7, MHC class I surface levels are elevated due to decreased endocytosis and degradation. Internalization of MHC class I molecules occurs less efficiently if AAK1 cannot be recruited via Atg8/LC3B. In the absence of Atg-dependent MHC class I internalization, dendritic cells stimulate CD8+ T cell responses more efficiently in vitro and in vivo. During viral infections, lack of Atg5 results in enhanced influenza- and LCMV-specific CD8+ T cell responses in vivo. Elevated influenza-specific CD8+ T cell responses are associated with better immune control of this infection. Thus, the macroautophagy machinery orchestrates T cell immunity by supporting MHC class II but compromises MHC class I restricted antigen presentation.

  15. Responsibility and Responsiveness

    DEFF Research Database (Denmark)

    Nissen, Ulrik Becker


    in a differentiated unity with each other. This idea can be substantiated by a figurative appropriation of a Chalcedonian Christology, particularly the communicatio idiomatum. The communicative dimension of this concept has been found to be useful for a reinterpretation of the idea of responsibility. By engaging...

  16. Regional signatures of plant response to drought and elevated temperature across a desert ecosystem. (United States)

    Munson, Seth M; Muldavin, Esteban H; Belnap, Jayne; Peters, Debra P C; Anderson, John P; Reiser, M Hildegard; Gallo, Kirsten; Melgoza-Castillo, Alicia; Herrick, Jeffrey E; Christiansen, Tim A


    The performance of many desert plant species in North America may decline with the warmer and drier conditions predicted by climate change models, thereby accelerating land degradation and reducing ecosystem productivity. We paired repeat measurements of plant canopy cover with climate at multiple sites across the Chihuahuan Desert over the last century to determine which plant species and functional types may be the most sensitive to climate change. We found that the dominant perennial grass, Bouteloua eriopoda, and species richness had nonlinear responses to summer precipitation, decreasing more in dry summers than increasing with wet summers. Dominant shrub species responded differently to the seasonality of precipitation and drought, but winter precipitation best explained changes in the cover of woody vegetation in upland grasslands and may contribute to woody-plant encroachment that is widespread throughout the southwestern United States and northern Mexico. Temperature explained additional variability of changes in cover of dominant and subdominant plant species. Using a novel empirically based approach we identified "climate pivot points" that were indicative of shifts from increasing to decreasing plant cover over a range of climatic conditions. Reductions in cover of annual and several perennial plant species, in addition to declines in species richness below the long-term summer precipitation mean across plant communities, indicate a decrease in the productivity for all but the most drought-tolerant perennial grasses and shrubs in the Chihuahuan Desert. Overall, our regional synthesis of long-term data provides a robust foundation for forecasting future shifts in the composition and structure of plant assemblages in the largest North American warm desert.

  17. Immune response of calves inoculated with proteins ofAnaplasma marginale bound to an immunostimulant complex

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    Marcela Ribeiro Gasparini

    Full Text Available Despite our current knowledge of the immunology, pathology, and genetics of Anaplasma marginale, prevention in cattle is currently based on old standbys, including live attenuated vaccines, antibiotic treatment, and maintaining enzootic stability in cattle herds. In the present study, we evaluated the use of an immunostimulant complex (ISCOMATRIX adjuvant, associated with a pool of recombinant major surface proteins (rMSP1a, rMSP1b, rMSP4 and rMSP5 to improve the humoral immune response triggered in calves mainly by IgG2. Ten calves were divided in three groups: 4 calves were inoculated with the ISCOMATRIX/rMSPs (G1; 2 calves were inoculated with ISCOMATRIX adjuvant (G2; and 4 calves received saline (G3. Three inoculations were administered at 21-day intervals. In G1, the calves showed significant increases in total IgG, IgG1 and IgG2 levels 21 days after the second inoculation, compared to the control group (p < 0.05, and G1 calves remained above the cut-off value 28 days after the third inoculation (p < 0.05. The post-immunized sera from calves in G1 reacted specifically for each of the rMSPs used. In conclusion, the ISCOMATRIX/rMSPs induced antigen-specific seroconversion in calves. Therefore, additional testing to explore the protection induced by rMSPs, both alone and in conjunction with proteins previously identified as subdominant epitopes, is warranted.

  18. Corporate Responsibility

    DEFF Research Database (Denmark)

    Waddock, Sandra; Rasche, Andreas


    We define and discuss the concept of corporate responsibility. We suggest that corporate responsibility has some unique characteristics, which makes it different from earlier conceptions of corporate social responsibility. Our discussion further shows commonalities and differences between corporate...... responsibility and related concepts, such as corporate citizenship and business ethics. We also outline some ways in which corporations have implemented corporate responsibility in practice....

  19. Cigarette smoke inhibits BAFF expression and mucosal immunoglobulin A responses in the lung during influenza virus infection. (United States)

    Wang, Jianmiao; Li, Qinghai; Xie, Jungang; Xu, Yongjian


    It is incompletely understood how cigarette smoke (CS) exposure affects lung mucosal immune responses during viral respiratory infections. B cell activating factor belonging to the tumor necrosis factor family (BAFF) plays an important role in the induction of secretory immunoglobulin A (S-IgA) which is the main effector of the mucosal immune system. We therefore investigated the effects of CS exposure on BAFF expression and S-IgA responses in the lung during influenza virus infection. Mice were exposed to CS and/or infected with influenza virus. Bronchoalveolar lavage fluid and lung compartments were analyzed for BAFF expression, influenza-specific S-IgA level and histological changes. Lung B cells were isolated and the activation-induced cytidine deaminase (Aicda) expression was determined. BEAS-2B cells were treated with CS extract (CSE), influenza virus, interferon beta or N-acetylcysteine and BAFF expression was measured. CS inhibited BAFF expression in the lung, particularly after long-term exposure. BAFF and S-IgA levels were increased during influenza virus infection. Three-month CS exposure prior to influenza virus infection resulted in reduced BAFF and S-IgA levels in the lung as well as augmented pulmonary inflammation on day 7 after infection. Prior CS exposure also caused decreased Aicda expression in lung B cells during infection. Neutralization of BAFF in the lung resulted in reduced S-IgA levels during influenza virus infection. CSE inhibited virus-mediated BAFF induction in a dose-dependent manner in BEAS-2B cells, while this inhibition of BAFF by CSE was prevented by pretreatment with the antioxidant N-acetylcysteine. Our findings indicate that CS may hinder early mucosal IgA responses in the lung during influenza virus infection through oxidative inhibition of BAFF, which might contribute to the increased incidence and severity of viral infections in smokers.

  20. H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination.

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    M Anthony Moody

    Full Text Available BACKGROUND: During the recent H1N1 influenza pandemic, excess morbidity and mortality was seen in young but not older adults suggesting that prior infection with influenza strains may have protected older subjects. In contrast, a history of recent seasonal trivalent vaccine in younger adults was not associated with protection. METHODS AND FINDINGS: To study hemagglutinin (HA antibody responses in influenza immunization and infection, we have studied the day 7 plasma cell repertoires of subjects immunized with seasonal trivalent inactivated influenza vaccine (TIV and compared them to the plasma cell repertoires of subjects experimentally infected (EI with influenza H3N2 A/Wisconsin/67/2005. The majority of circulating plasma cells after TIV produced influenza-specific antibodies, while most plasma cells after EI produced antibodies that did not react with influenza HA. While anti-HA antibodies from TIV subjects were primarily reactive with single or few HA strains, anti-HA antibodies from EI subjects were isolated that reacted with multiple HA strains. Plasma cell-derived anti-HA antibodies from TIV subjects showed more evidence of clonal expansion compared with antibodies from EI subjects. From an H3N2-infected subject, we isolated a 4-member clonal lineage of broadly cross-reactive antibodies that bound to multiple HA subtypes and neutralized both H1N1 and H3N2 viruses. This broad reactivity was not detected in post-infection plasma suggesting this broadly reactive clonal lineage was not immunodominant in this subject. CONCLUSION: The presence of broadly reactive subdominant antibody responses in some EI subjects suggests that improved vaccine designs that make broadly reactive antibody responses immunodominant could protect against novel influenza strains.

  1. H3N2 Influenza Infection Elicits More Cross-Reactive and Less Clonally Expanded Anti-Hemagglutinin Antibodies Than Influenza Vaccination (United States)

    Walter, Emmanuel B.; Woods, Christopher W.; Ginsburg, Geoffrey S.; McClain, Micah T.; Denny, Thomas N.; Chen, Xi; Munshaw, Supriya; Marshall, Dawn J.; Whitesides, John F.; Drinker, Mark S.; Amos, Joshua D.; Gurley, Thaddeus C.; Eudailey, Joshua A.; Foulger, Andrew; DeRosa, Katherine R.; Parks, Robert; Meyerhoff, R. Ryan; Yu, Jae-Sung; Kozink, Daniel M.; Barefoot, Brice E.; Ramsburg, Elizabeth A.; Khurana, Surender; Golding, Hana; Vandergrift, Nathan A.; Alam, S. Munir; Tomaras, Georgia D.; Kepler, Thomas B.; Kelsoe, Garnett; Liao, Hua-Xin; Haynes, Barton F.


    Background During the recent H1N1 influenza pandemic, excess morbidity and mortality was seen in young but not older adults suggesting that prior infection with influenza strains may have protected older subjects. In contrast, a history of recent seasonal trivalent vaccine in younger adults was not associated with protection. Methods and Findings To study hemagglutinin (HA) antibody responses in influenza immunization and infection, we have studied the day 7 plasma cell repertoires of subjects immunized with seasonal trivalent inactivated influenza vaccine (TIV) and compared them to the plasma cell repertoires of subjects experimentally infected (EI) with influenza H3N2 A/Wisconsin/67/2005. The majority of circulating plasma cells after TIV produced influenza-specific antibodies, while most plasma cells after EI produced antibodies that did not react with influenza HA. While anti-HA antibodies from TIV subjects were primarily reactive with single or few HA strains, anti-HA antibodies from EI subjects were isolated that reacted with multiple HA strains. Plasma cell-derived anti-HA antibodies from TIV subjects showed more evidence of clonal expansion compared with antibodies from EI subjects. From an H3N2-infected subject, we isolated a 4-member clonal lineage of broadly cross-reactive antibodies that bound to multiple HA subtypes and neutralized both H1N1 and H3N2 viruses. This broad reactivity was not detected in post-infection plasma suggesting this broadly reactive clonal lineage was not immunodominant in this subject. Conclusion The presence of broadly reactive subdominant antibody responses in some EI subjects suggests that improved vaccine designs that make broadly reactive antibody responses immunodominant could protect against novel influenza strains. PMID:22039424

  2. A trivalent virus-like particle vaccine elicits protective immune responses against seasonal influenza strains in mice and ferrets.

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    Ted M Ross

    Full Text Available There is need for improved human influenza vaccines, particularly for older adults who are at greatest risk for severe disease, as well as to address the continuous antigenic drift within circulating human subtypes of influenza virus. We have engineered an influenza virus-like particle (VLP as a new generation vaccine candidate purified from the supernatants of Sf9 insect cells following infection by recombinant baculoviruses to express three influenza virus proteins, hemagglutinin (HA, neuraminidase (NA, and matrix 1 (M1. In this study, a seasonal trivalent VLP vaccine (TVV formulation, composed of influenza A H1N1 and H3N2 and influenza B VLPs, was evaluated in mice and ferrets for the ability to elicit antigen-specific immune responses. Animals vaccinated with the TVV formulation had hemagglutination-inhibition (HAI antibody titers against all three homologous influenza virus strains, as well as HAI antibodies against a panel of heterologous influenza viruses. HAI titers elicited by the TVV were statistically similar to HAI titers elicited in animals vaccinated with the corresponding monovalent VLP. Mice vaccinated with the TVV had higher level of influenza specific CD8+ T cell responses than a commercial trivalent inactivated vaccine (TIV. Ferrets vaccinated with the highest dose of the VLP vaccine and then challenged with the homologous H3N2 virus had the lowest titers of replicating virus in nasal washes and showed no signs of disease. Overall, a trivalent VLP vaccine elicits a broad array of immunity and can protect against influenza virus challenge.

  3. Sustainable responsibilities?

    DEFF Research Database (Denmark)

    Lystbæk, Christian Tang


    This working paper analyzes the conceptions of corporate responsibility for sustainable development in EU policies on CSR. The notion of corporate responsibility has until recently been limited to economical and legal responsibilities. Based on this narrow conception of corporate responsibility.......e. a combination of destruction and construction, this chapter will deconstruct conceptions of responsibility for sustainable development in these EU documents on CSR. A deconstructive conceptual analysis involves destructing dominant interpretations of a text and allowing for constructions of alternative...... such as sustainability actually means, but on what the concept says and does not say. A deconstructive analysis of EU policies on CSR, then, pinpoints that such policies are sites of conceptual struggles. This kind of analysis is suitable for studying conceptions of corporate responsibility for sustainable development...

  4. [Medical responsibility]. (United States)

    Lassale, B


    Blood transfusion is a medical act, which follows the dictates of important rules in medical responsability. The following presentation will mention the legal responsibility of the practitioner throughout the transfusion process: first, giving the patient complete and precise information and geting his full consent; then, writing the appropriate prescription; finally, balancing the benefice and risk of therapy and using reglementation to avoid the practitioner's responsibility to be put at risks.

  5. Shift in epitope dominance of IgM and IgG responses to Plasmodium falciparum MSP1 block 4

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    Leke Rose GF


    Full Text Available Abstract Background Plasmodium falciparum merozoite surface protein-1 (MSP1 has been extensively studied as a blood-stage malaria vaccine candidate, with most work focused on the conserved 19 kDa and semi-conserved 42 kDa C-terminal regions (blocks 16-17 and the hypervariable N-terminal repeat region (block 2. However, recent genotyping studies suggest that additional regions of MSP1 may be under selective pressure, including a locus of intragenic recombination designated as block 4 within the 3' region of the gene. Methods The current study examined the antibody response to the two parental and two recombinant forms of block 4 and to blocks 16-17 (3D7 in study populations from Colombia, Papua New Guinea and Cameroon that differ in malaria transmission intensity and ethnic composition. Results IgM and IgG antibodies were detected against parental and recombinant MSP1 block 4 peptides in all three populations. Overall, 32-44% of the individuals produced IgM to one or more of the peptides, with most individuals having IgM antibodies reactive with both parental and recombinant forms. In contrast, IgG seropositivity to block 4 varied among populations (range 15-65%, with the majority of antibodies showing specificity for one or a pair of block 4 peptides. The IgG response to block 4 was significantly lower than that to blocks 16-17, indicating block 4 is subdominant. Antibodies to block 4 and blocks 16-17 displayed distinct IgG subclass biases, with block 4 responses biased toward IgG3 and blocks 16-17 toward IgG1. These patterns of responsiveness were consistently observed in the three study populations. Conclusions Production of antibodies specific for each parental and recombinant MSP1 block 4 allele in different populations exposed to P. falciparum is consistent with balancing selection of the MSP1 block 4 region by the immune response of individuals in areas of both low and high malaria transmission. MSP1 block 4 determinants may be important

  6. Consequences of bulk odd-frequency superconducting states for the classification of Cooper pairs


    Asano, Yasuhiro; Fominov, Yakov V.; Tanaka, Yukio


    We analyze symmetries and magnetic properties of Cooper pairs appearing as subdominant pairing correlations in inhomogeneous superconductors, on the basis of the quasiclassical Green-function theory. The frequency symmetry, parity, and the type of magnetic response of such subdominant correlations are opposite to those of the dominant pairing correlations in the bulk state. Our conclusion is valid even when we generalize the theory of superconductivity to recently proposed diamagnetic odd-fre...

  7. Competing responsibly

    NARCIS (Netherlands)

    Jeurissen, R.J.M.; Ven, van de B.W.


    In this paper we examine the effects of different competitive conditions on the determination and evaluation of strategies of corporate social responsibility (CSR). Although the mainstream of current thinking in business ethics recognizes that a firm should invest in social responsibility, the

  8. Query responses

    Directory of Open Access Journals (Sweden)

    Paweł Łupkowski


    Full Text Available In this article we consider the phenomenon of answering a query with a query. Although such answers are common, no large scale, corpus-based characterization exists, with the exception of clarification requests. After briefly reviewing different theoretical approaches on this subject, we present a corpus study of query responses in the British National Corpus and develop a taxonomy for query responses. We point at a variety of response categories that have not been formalized in previous dialogue work, particularly those relevant to adversarial interaction. We show that different response categories have significantly different rates of subsequent answer provision. We provide a formal analysis of the response categories in the framework of KoS.

  9. Human immunodeficiency virus type 1 specific cytotoxic T lymphocyte responses in Chinese infected with HIV-1 B'/C Recombinant (CRF07_BC

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    Yu Xu G


    Full Text Available Abstract Background The characterization of HIV-1-specific T cell responses in people infected with locally circulating HIV-1 strain will facilitate the development of HIV-1 vaccine. Sixty intravenous drug users infected with HIV-1 circulating recombinant form 07_BC (CRF07_BC, which has been spreading rapidly in western China from north to south, were recruited from Xinjiang, China to assess the HIV-1-specific T cell responses at single peptide level with overlapping peptides (OLP covering the whole concensus clades B and C proteome. Results The median of the total magnitude and total number of OLPs recognized by CTL responses were 10925 SFC/million PBMC and 25 OLPs, respectively, when tested by clade C peptides, which was significantly higher than when tested by clade B peptides. The immunodominant regions, which cover 14% (58/413 of the HIV-1 proteome, are widely distributed throughout the HIV-1 proteome except in Tat, Vpu and Pol-PR, with Gag, Pol-RT, Pol-Int and Nef being most frequently targeted. The subdominant epitopes are mostly located in p24, Nef, integrase, Vpr and Vif. Of the responses directed to clade C OLPs, 61.75% (972/1574 can be observed when tested with corresponding clade B OLPs. However, Pol-PR and Vpu tend to be targeted in the clade B sequence rather than the clade C sequence, which is in line with the recombinant pattern of CRF07_BC. Stronger and broader CTL responses in subjects with CD4 cell counts ranging from 200 to 400/mm3 were observed when compared to those with less than 200/mm3 or more than 400/mm3, though there have been no significant correlations identified between the accumulative CTL responses or overall breadth and CD4 cell count or plasma viral load. Conclusion This is the first study conducted to comprehensively address T cell responses in Chinese subjects infected with HIV-1 CRF07_BC in which subtle differences in cross-reactivity were observed, though similar patterns of overall immune responses were

  10. Impaired immune responses in the lungs of aged mice following influenza infection

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    Toapanta Franklin R


    Full Text Available Abstract Background Each year, influenza virus infection causes severe morbidity and mortality, particularly in the most susceptible groups including children, the elderly (>65 years-old and people with chronic respiratory diseases. Among the several factors that contribute to the increased susceptibility in elderly populations are the higher prevalence of chronic diseases (e.g. diabetes and the senescence of the immune system. Methods In this study, aged and adult mice were infected with sublethal doses of influenza virus (A/Puerto Rico/8/1934. Differences in weight loss, morbidity, virus titer and the kinetics of lung infiltration with cells of the innate and adaptive immune responses were analyzed. Additionally, the main cytokines and chemokines produced by these cells were also assayed. Results Compared to adult mice, aged mice had higher morbidity, lost weight more rapidly, and recovered more slowly from infection. There was a delay in the accumulation of granulocytic cells and conventional dendritic cells (cDCs, but not macrophages in the lungs of aged mice compared to adult animals. The delayed infiltration kinetics of APCs in aged animals correlated with alteration in their activation (CD40 expression, which also correlated with a delayed detection of cytokines and chemokines in lung homogenates. This was associated with retarded lung infiltration by natural killer (NK, CD4+ and CD8+ T-cells. Furthermore, the percentage of activated (CD69+ influenza-specific and IL-2 producer CD8+ T-cells was higher in adult mice compared to aged ones. Additionally, activation (CD69+ of adult B-cells was earlier and correlated with a quicker development of neutralizing antibodies in adult animals. Conclusion Overall, alterations in APC priming and activation lead to delayed production of cytokines and chemokines in the lungs that ultimately affected the infiltration of immune cells following influenza infection. This resulted in delayed activation of the

  11. Emergency Response (United States)

    Information for first responders, industry, federal, state and local governments on EPA's role and available resources for response to oil spills, chemical, biological, radiological releases, and large-scale national emergencies.

  12. The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi.

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    Jonatan Ersching


    Full Text Available The β1i, β2i and β5i immunoproteasome subunits have an important role in defining the repertoire of MHC class I-restricted epitopes. However, the impact of combined deficiency of the three immunoproteasome subunits in the development of protective immunity to intracellular pathogens has not been investigated. Here, we demonstrate that immunoproteasomes play a key role in host resistance and genetic vaccination-induced protection against the human pathogen Trypanosoma cruzi (the causative agent of Chagas disease, immunity to which is dependent on CD8+ T cells and IFN-γ (the classical immunoproteasome inducer. We observed that infection with T. cruzi triggers the transcription of immunoproteasome genes, both in mice and humans. Importantly, genetically vaccinated or T. cruzi-infected β1i, β2i and β5i triple knockout (TKO mice presented significantly lower frequencies and numbers of splenic CD8+ effector T cells (CD8+CD44highCD62Llow specific for the previously characterized immunodominant (VNHRFTLV H-2Kb-restricted T. cruzi epitope. Not only the quantity, but also the quality of parasite-specific CD8+ T cell responses was altered in TKO mice. Hence, the frequency of double-positive (IFN-γ+/TNF+ or single-positive (IFN-γ+ cells specific for the H-2Kb-restricted immunodominant as well as subdominant T. cruzi epitopes were higher in WT mice, whereas TNF single-positive cells prevailed among CD8+ T cells from TKO mice. Contrasting with their WT counterparts, TKO animals were also lethally susceptible to T. cruzi challenge, even after an otherwise protective vaccination with DNA and adenoviral vectors. We conclude that the immunoproteasome subunits are key determinants in host resistance to T. cruzi infection by influencing both the magnitude and quality of CD8+ T cell responses.

  13. Responsive Innovation

    DEFF Research Database (Denmark)

    Pedersen, Carsten

    of the firm’s daily operations. Yet, they are rarely asked to provide updated information about critical issues. The present paper seeks to conceptually develop the notion of responsive innovation, by drawing on literary streams concerning collective sensing, strategic issue diagnosis and integra......-tive strategy within a micro foundations perspective. It is posited that companies should root their innovation processes in the collective sensing of frontline-employees and customers that operate around the organizational periphery. This frames the con-cept of responsive innovation, where individuals engaged...

  14. Designing responsibility

    NARCIS (Netherlands)

    Gertz, Nolen


    Technology can mediate not only our nihilism, but also our responsibility. In order to achieve the latter rather than the former, we need to move away from the model of freedom we have been following from Aristotle to Marx to today, that more leisure means more freedom. Through the insights found in

  15. Authors’ Response

    DEFF Research Database (Denmark)

    Alrøe, Hugo Fjelsted; Noe, Egon


    Upshot: In our response we focus on five questions that point to important common themes in the commentaries: why start in wicked problems, what kind of system is a scientific perspective, what is the nature of second-order research processes, what does this mean for understanding interdisciplinary...

  16. A Response. (United States)

    Wilson, John


    Presents John Wilson's response to the articles within this issue of the "Journal of Moral Education". Focuses on broad issues related to the disagreements that surfaced. Explains that one issue concerns the nature of philosophical or conceptual analysis. Addresses aspects of his own work. (CMK)

  17. Emociones responsables

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    Valdecantos, Antonio


    Full Text Available A properly moral responsibility is currently distinguished from other uses of this concept. It is orthodox to attribute three traits to moral responsibility: the obligation to answer with reasons, the obligation to compensate for the damage, and the withdrawal of such a responsibility once the retrieval has been paid. It is also fraquently assumed that the analysis of so called moral emotions confirms the validity of the orthodox notion. I maintain that the description of indignation (a caracteristically moral emotion strongly attacks the orthodox notion. On my view, indignation implies a distinctive notion of responsibility, excluding the second and third traits of the orthodox conception. Moral responsibility is an anomaly of morals. This form of responsibility is highly akin to the one proposed by the Spanish writer Rafael Sánchez Ferlosio in El alma y la vergüenza (Soul and shame, 2000. My revision of moral responsibility is designed to exemplify a conception of morality itself as a set of «anomalies».

    Es corriente distinguir la responsabilidad propiamente moral de otros usos de este mismo concepto. De ordinario se cree que la responsabilidad moral tiene tres rasgos: la exigencia de responder con razones, la obligación de resarcir por el daño causado y la cancelación de dicha responsabilidad una vez efectuada la reparación. Se supone también que el análisis de las emociones llamadas morales confirma la bondad de esta noción ortodoxa. Sostengo que esto último no es cierto, o que no lo es, al menos, a partir de lo que suele entenderse por indignación (una de las emociones típicamente morales. En realidad, la indignación no exige la responsabilidad moral ortodoxa, sino otra que elimina sus rasgos segundo y tercero. La responsabilidad moral es una anomalía de la moral. Esta forma de responsabilidad es muy semejante a la que ha propuesto Rafael Sánchez Ferlosio en El alma y la vergüenza (2000. La

  18. Antigen-specific H1N1 influenza antibody responses in acute respiratory tract infections and their relation to influenza infection and disease course. (United States)

    Haran, John Patrick; Hoaglin, David C; Chen, Huaiqing; Boyer, Edward W; Lu, Shan


    Early antibody responses to influenza infection are important in both clearance of virus and fighting the disease. Acute influenza antibody titers directed toward H1-antigens and their relation to infection type and patient outcomes have not been well investigated. Using hemagglutination inhibition (HI) assays, we aimed to characterize the H1-specific antibody titers in patients with influenza infection or another respiratory infection before and after the H1N1-pandemic influenza outbreak. Among patients with acute influenza infection we related duration of illness, severity of symptoms, and need for hospitalization to antibody titers. There were 134 adult patients (average age 34.7) who presented to an urban academic emergency department (ED) from October through March during the 2008-2011 influenza seasons with symptoms of fever and a cough. Nasal aspirates were tested by viral culture, and peripheral blood serum was run in seven H1-subtype HI assays. Acutely infected influenza patients had markedly lower antibody titers for six of the seven pseudotype viruses. For the average over the seven titers (log units, base 2) their mean was 7.24 (95% CI 6.88, 7.61) compared with 8.60 (95% CI 8.27, 8.92) among patients who had a non-influenza respiratory illness, pinfection, titers of some antibodies correlated with severity of symptoms and with total duration of illness (pacute respiratory infections, lower concentrations of H1-influenza-specific antibodies were associated with influenza infection. Among influenza-infected patients, higher antibody titers were present in patients with a longer duration of illness and with higher severity-of-symptom scores. Copyright © 2014 Elsevier B.V. All rights reserved.

  19. Responsive Lotteries (United States)

    Feige, Uriel; Tennenholtz, Moshe

    Given a set of alternatives and a single player, we introduce the notion of a responsive lottery. These mechanisms receive as input from the player a reported utility function, specifying a value for each one of the alternatives, and use a lottery to produce as output a probability distribution over the alternatives. Thereafter, exactly one alternative wins (is given to the player) with the respective probability. Assuming that the player is not indifferent to which of the alternatives wins, a lottery rule is called truthful dominant if reporting his true utility function (up to affine transformations) is the unique report that maximizes the expected payoff for the player. We design truthful dominant responsive lotteries. We also discuss their relations with scoring rules and with VCG mechanisms.

  20. Responsive Innovation

    DEFF Research Database (Denmark)

    Pedersen, Carsten

    Although the importance of stakeholder networks has been recognized in recent years, a non-teleological model that incorporates their collective sensing into innovation processes has so far not been developed. Hence, this paper argues that traditional linear and sequential innovation models...... are insufficient in hypercompetitive environments. Instead, it is proposed that companies should ground their innovation processes in the collective sensing of frontline-employees and customers that operate around the organizational periphery. This frames the concept of responsive innovation, where key...

  1. Priming by a novel universal influenza vaccine (Multimeric-001)-a gateway for improving immune response in the elderly population. (United States)

    Atsmon, Jacob; Caraco, Yoseph; Ziv-Sefer, Sagit; Shaikevich, Dimitry; Abramov, Ester; Volokhov, Inna; Bruzil, Svetlana; Haima, Kirsten Y; Gottlieb, Tanya; Ben-Yedidia, Tamar


    A new vaccine, "Multimeric-001" (M-001) has been recently developed, containing conserved, common linear influenza epitopes that activate both cellular and humoral arms of the immune system against a wide variety of influenza A and B strains. Apart from its direct action, M-001 is an attractive candidate for priming immune responses to seasonal influenza vaccine for the elderly population. The current clinical study was designed to assess M-001's standalone and priming action in participants over 65 years old. Evaluation of standalone action is based on induction of cell mediated immunity (CMI), since M-001 alone does not induce hemagglutinin inhibition (HAI) antibodies. This was a two-center, randomized, placebo-controlled study. 120 participants were randomized 1:1:1:1 into four groups to receive either two sequential non-adjuvanted or a single non-adjuvanted or a single adjuvanted intramuscular injection of 500 mcg M-001 (treatment), or one placebo (saline) injection, before receiving the trivalent inactivated influenza vaccine (TIV). Due to visual differences between placebo and treatment the study was partially blinded. HAI was evaluated at baseline and 3 weeks after standard TIV vaccination as a measure of M-001's efficacy. CMI responses were evaluated in a subset (10/group) of the participants. Participants were monitored for safety throughout the study. Overall the treatment was well-tolerated and safe, though sample sizes allowed only limited statistical analysis. M-001 priming resulted in enhanced seroconversion towards all three TIV strains, compared to priming with placebo. Significant elevation of influenza-specific CMI was observed following immunization with M-001 alone. The standalone and priming actions of M-001 were demonstrated in elderly participants despite the limitations of small population size and pre-existing HAI antibody titers in some participants. As a standalone vaccine, M-001 induced significant CMI to multiple strains and as a primer

  2. Emotional Responses

    DEFF Research Database (Denmark)

    Hansen, Flemming; Christensen, Sverre Riis; Lundsteen, Steen


    Recent neurological research has pointed to the importance of fundamental emotional processes for most kinds of human behaviour. Measures of emotional response tendencies towards brands seem to reveal intangible aspects of brand equity, particularly in a marketing context. In this paper a procedure...... for estimating such emotional brand equity is presented and findings from two successive studies of more than 100 brands are reported. It demonstrates how changes that occur between two years are explainable in terms of factors identifiable in the markets, and that the measures otherwise are stable over time....... Also, it is shown that the measurement procedure is extremely robust....

  3. Photoparoxysmal responses

    Directory of Open Access Journals (Sweden)

    Mauro Muszkat


    Full Text Available Sixty-five outpatients with photoparoxysmal response (PPR during routine EEG were studied. The PPR showed prevalence in women (75.4%. Seizures were found in 66.1% of cases. The rest recordings were abnormal in 41.8% with prevalence of generalized paroxysm. Eight patterns of PPR were observed, being polyspike mixed to slow wave the most frequent (53%. The epileptic group showed a bimodal distribution in the several bands of photic stimulation, near 8 and 20-24 Hz. A sustained paroxysmal abnormality persisting after the photic stimulation was present in 6 epileptic patients.

  4. Naturalizing Responsibility. (United States)

    Zullo, Silvia


    In the contemporary debate on the use of the neurosciences in ethics and law, numerous arguments have been bandied about among scientists and philosophers looking to uphold or reject the reliability and validity of scientific findings obtained by brain imaging technologies. Among the most vexing questions is, Can we trust that technology? One point of disagreement is whether brain scans offer a window through which to observe the functioning of the mind, in such a way as to enable lawyers, judges, physicians, and lawmakers to detect anomalies in brain function that may account for criminal unconscious behavior. Those who stand behind brain imaging believe that this can indeed be achieved, whereas those in opposition stress that brain scans are highly open to interpretation and that the data they provide is insufficient to establish causal connections. The question essentially comes down to whether technology can reliably be used to determine the intentions of the individual, thus establishing mens rea, for example, and hence responsibility. This article focuses on the latter notion and explores whether we can rely on the neurosciences to shed light on a complex form of moral and legal reasoning, as well as the role of the neurosciences in reawakening a philosophical and legal interest in trying to set responsibility on an empirical basis.

  5. Responsible innovation

    CERN Document Server

    De Woot, Philippe


    Economic development is rooted in disruption, not in equilibrium. And a powerful engine of economic development is innovation; but is this innovation always for the common good? The dark side of the extraordinary dynamism of innovation lies precisely in its destructive power. If simply left to market forces, it could lead to social chaos and great human suffering. To face the challenges of our time, we must create the proper climate and culture to develop strong entrepreneurial drive. But, more than ever, we must give this entrepreneurial drive its ethical and societal dimensions. Responsible innovation means a more voluntary orientation towards the great problems of the 21st century, e.g. depletion of the planet's resources, rising inequality, and new scientific developments potentially threatening freedom, democracy and human integrity. We need to transform our ceaseless creativity into real progress for humankind. In this respect, the rapid development of social innovation opens the door for new methods an...

  6. Increase in IFNγ(-IL-2(+ cells in recent human CD4 T cell responses to 2009 pandemic H1N1 influenza.

    Directory of Open Access Journals (Sweden)

    Jason M Weaver

    Full Text Available Human CD4 T cell recall responses to influenza virus are strongly biased towards Type 1 cytokines, producing IFNγ, IL-2 and TNFα. We have now examined the effector phenotypes of CD4 T cells in more detail, particularly focusing on differences between recent versus long-term, multiply-boosted responses. Peptides spanning the proteome of temporally distinct influenza viruses were distributed into pools enriched for cross-reactivity to different influenza strains, and used to stimulate antigen-specific CD4 T cells representing recent or long-term memory. In the general population, peptides unique to the long-circulating influenza A/New Caledonia/20/99 (H1N1 induced Th1-like responses biased toward the expression of IFNγ(+TNFα(+ CD4 T cells. In contrast, peptide pools enriched for non-cross-reactive peptides of the pandemic influenza A/California/04/09 (H1N1 induced more IFNγ(-IL-2(+TNFα(+ T cells, similar to the IFNγ(-IL-2(+ non-polarized, primed precursor T cells (Thpp that are a predominant response to protein vaccination. These results were confirmed in a second study that compared samples taken before the 2009 pandemic to samples taken one month after PCR-confirmed A/California/04/09 infection. There were striking increases in influenza-specific TNFα(+, IFNγ(+, and IL-2(+ cells in the post-infection samples. Importantly, peptides enriched for non-cross-reactive A/California/04/09 specificities induced a higher proportion of Thpp-like IFNγ(-IL-2(+TNFα(+ CD4 T cells than peptide pools cross-reactive with previous influenza strains, which induced more Th1 (IFNγ(+TNFα(+ responses. These IFNγ(-IL-2(+TNFα(+ CD4 T cells may be an important target population for vaccination regimens, as these cells are induced upon infection, may have high proliferative potential, and may play a role in providing future effector cells during subsequent infections.

  7. The role of membrane fusion activity of a whole inactivated influenza virus vaccine in (re)activation of influenza-specific cytotoxic T lymphocytes

    NARCIS (Netherlands)

    Budimir, Natalija; Meijerhof, Tjarko; Wilschut, Jan; Huckriede, Anke; de Haan, Aalzen


    Induction of cytotoxic T lymphocyte (CTL) activity against conserved influenza antigens, e.g. nucleoprotein (NP) could be a step towards cross-protective influenza vaccine. The major challenge for non-replicating influenza vaccines aiming for activation of CTLs is targeting of antigen to the MHC

  8. Cultural Studies, Pedagogy, and Response-Ability (United States)

    Rossiter, Penelope


    A few years ago, in a tutorial in an advanced level undergraduate subject that she teaches--"Emotions, Culture and Community"--the author was a witness and participant in a pedagogical event that moved and provoked the class: It incited response-ability. This article is about that event, the meaning of response-ability, and the window…

  9. Modeling Response Signal and Response Time Data (United States)

    Ratcliff, Roger


    The diffusion model (Ratcliff, 1978) and the leaky competing accumulator model (LCA, Usher & McClelland, 2001) were tested against two-choice data collected from the same subjects with the standard response time procedure and the response signal procedure. In the response signal procedure, a stimulus is presented and then, at one of a number of…

  10. Poorly Responsive Celiac Disease (United States)

    ... Celiac Disease › Poorly Responsive Celiac Disease Poorly Responsive Celiac Disease It is estimated that up to 30% of ... continuing to ingest gluten. Causes of Poorly Responsive Celiac Disease Continuing Gluten Ingestion The most common reason for ...

  11. Optimal Responsible Investment

    DEFF Research Database (Denmark)

    Jessen, Pernille

    The paper studies retail Socially Responsible Investment and portfolio allocation. It extends conventional portfolio theory by allowing for a personal value based investment decision. When preferences for responsibility enter the framework for mean-variance analysis, it yields an optimal...... responsible investment model. An example of index investing illustrates the theory. Results show that it is crucial for the responsible investor to consider portfolio risk, expected return, and responsibility simultaneously in order to obtain an optimal portfolio. The model enables responsible investors...

  12. Responsibility in Labour Law


    Mandíková, Irena


    This thesis deals with responsibility in labour-law relationships. At the beginning, the thesis focuses on defining responsibility in labour law from a general perspective, in particular in the light of its characteristics. This part is followed by a classification of responsibility in terms of individual branches of law. A prevalent part of this thesis examines the most common type of labour-law responsibility, i.e. responsibility for damage. This part describes in detail the individual type...

  13. Vaccination of mice with plasmids expressing processed capsid protein of foot-and-mouth disease virus - Importance of dominant and subdominant epitopes for antigenicity and protection

    DEFF Research Database (Denmark)

    Frimann, Tine; Barfoed, Annette Malene; Aasted, Bent


    example of a dominant and variable site. This variability is a problem when designing vaccines against this disease, because it necessitates a close match between vaccine strain and virus in an outbreak. We have introduced a series of mutations into viral capsid proteins with the aim of selectively...... as compared to mice vaccinated with wild type epitopes. Most of the modifications did not adversely affect the ability of the plasmids to induce complete protection of mice against homologous challenge....

  14. Comparison of DNA extraction kits and modification of DNA elution procedure for the quantitation of subdominant bacteria from piggery effluents with real‐time PCR

    National Research Council Canada - National Science Library

    Desneux, Jérémy; Pourcher, Anne‐Marie


    Four commercial DNA extraction kits and a minor modification in the DNA elution procedure were evaluated for the quantitation of bacteria in pig manure samples. The PowerSoil ® , PowerFecal ® , NucleoSpin...

  15. Environmental Response Management Application (ERMA) Gulf Response (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Response Management Application (ERMA) (R) is a web-based Geographic Information System (GIS) tool that assists both emergency responders and...

  16. Science's social responsibility

    DEFF Research Database (Denmark)

    Sandvik, Kjetil


    What is science’s social responsibility? Is it like corporate responsibility an add-on to the main product: we produce knowledge and scientific solutions, but we also care for the environment, for sustainability, for fair-trade and so on? Or doesn’t social responsibility add to science at all...... solving problems and thus creating a base for science in its strategic mode, in its interplay-with-society mode. So science’s social responsibility may utter itself in various ways but I think it is fair to say that it is all about responsibility for taking part in making society move forward...... or to here-and-now social responsibility issues: science’s social responsibility is not just a responsibility towards today’s society, but also towards the societies which may evolve in the future....

  17. Responsibility and Capacities

    DEFF Research Database (Denmark)

    Ryberg, Jesper


    That responsible moral agency presupposes certain mental capacities, constitutes a widely accepted view among theorists. Moreover, it is often assumed that degrees in the development of the relevant capacities co-vary with degrees of responsibility. In this article it is argued that, the move from...... the view that responsibility requires certain mental capacities to the position that degrees of responsibility co-vary with degrees of the development of the mental capacities, is premature....

  18. Responsibility for others' emotions


    Rietti, Sophie


    Recent philosophical work on responsibility for emotion has tended to focus on what responsibility we can have for our own emotions. Folk psychology suggests we can also be responsible for others’ emotions, and they for ours, and that this can be reason for praise or blame . However, many branches of applied (and popular) psychology, and some schools of philosophy, deny there can be interpersonal responsibility for emotion. I shall be arguing here against this view, and for an account on whic...

  19. Stimulus Responsive Nanoparticles (United States)

    Cairns, Darran Robert (Inventor); Huebsch, Wade W. (Inventor); Sierros, Konstantinos A. (Inventor); Shafran, Matthew S. (Inventor)


    Disclosed are various embodiments of methods and systems related to stimulus responsive nanoparticles. In one embodiment including a stimulus responsive nanoparticle system, the system includes a first electrode, a second electrode, and a plurality of elongated electro-responsive nanoparticles dispersed between the first and second electrodes, the plurality of electro-responsive nanorods configured to respond to an electric field established between the first and second electrodes.

  20. Caution: Response to Intervention (United States)

    Johns, Beverley Holden; Kauffman, James M.


    The authors encourage caution in the implementation of Response to Intervention and dispel the false hopes that Response to Intervention will solve many of education's challenges. Outlined in this article are the reasons why Response to Intervention cannot be the solution to the identification of students for special education, why it can't…

  1. Playful Hyper Responsibility

    DEFF Research Database (Denmark)

    Knudsen, Hanne; Åkerstrøm Andersen, Niels


    Over the past 10–15 years, state-funded schools have begun to require parents to assume an undefined and infinite personal responsibility. In this article, we investigate how schools organize responsibility games to respond to this challenge and how these games affect the concept of responsibility...

  2. Aligning Responsible Business Practices

    DEFF Research Database (Denmark)

    Weller, Angeli E.


    This article offers an in-depth case study of a global high tech manufacturer that aligned its ethics and compliance, corporate social responsibility, and sustainability practices. Few large companies organize their responsible business practices this way, despite conceptual relevance and calls...... and managers interested in understanding how responsible business practices may be collectively organized....

  3. Optimal Responsible Investment

    DEFF Research Database (Denmark)

    Jessen, Pernille

    Numerous institutions are now engaged in Socially Responsible Investment or have signed the "UN Principles for Responsible Investment". Retail investors, however, are still lacking behind. This is peculiar since the sector constitutes key stakeholders in environmental, social and governmental...... standards. This paper considers optimal responsible investment for a small retail investor. It extends conventional portfolio theory by allowing for a personal-value based investment decision. Preferences for responsibility are defined in the framework of mean-variance analysis and an optimal responsible...... investment model identified. Implications of the altered investment problem are investigated when the dynamics between portfolio risk, expected return and responsibility is considered. Relying on the definition of a responsible investor, it is shown how superior investment opportunities can emerge when...

  4. The responsibilities of engineers. (United States)

    Smith, Justin; Gardoni, Paolo; Murphy, Colleen


    Knowledge of the responsibilities of engineers is the foundation for answering ethical questions about the work of engineers. This paper defines the responsibilities of engineers by considering what constitutes the nature of engineering as a particular form of activity. Specifically, this paper focuses on the ethical responsibilities of engineers qua engineers. Such responsibilities refer to the duties acquired in virtue of being a member of a group. We examine the practice of engineering, drawing on the idea of practices developed by philosopher Alasdair MacIntyre, and show how the idea of a practice is important for identifying and justifying the responsibilities of engineers. To demonstrate the contribution that knowledge of the responsibilities of engineers makes to engineering ethics, a case study from structural engineering is discussed. The discussion of the failure of the Sleipner A Platform off the coast of Norway in 1991 demonstrates how the responsibilities of engineers can be derived from knowledge of the nature of engineering and its context.

  5. Space race functional responses. (United States)

    Sjödin, Henrik; Brännström, Åke; Englund, Göran


    We derive functional responses under the assumption that predators and prey are engaged in a space race in which prey avoid patches with many predators and predators avoid patches with few or no prey. The resulting functional response models have a simple structure and include functions describing how the emigration of prey and predators depend on interspecific densities. As such, they provide a link between dispersal behaviours and community dynamics. The derived functional response is general but is here modelled in accordance with empirically documented emigration responses. We find that the prey emigration response to predators has stabilizing effects similar to that of the DeAngelis-Beddington functional response, and that the predator emigration response to prey has destabilizing effects similar to that of the Holling type II response. A stability criterion describing the net effect of the two emigration responses on a Lotka-Volterra predator-prey system is presented. The winner of the space race (i.e. whether predators or prey are favoured) is determined by the relationship between the slopes of the species' emigration responses. It is predicted that predators win the space race in poor habitats, where predator and prey densities are low, and that prey are more successful in richer habitats. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  6. Responsible geographies and geographies of response

    DEFF Research Database (Denmark)

    Grindsted, Thomas Skou

    and responsibilities concerning academic fights over representing global environmental change. A major part concerns the theoretical basis and draws inspiration from a series of critical geographical work on the marketization of universities, and relates this tincture to the wider education for sustainability...... the reading and writing of global environmental change....

  7. The variable effects of soil nitrogen availability and insect herbivory on aboveground and belowground plant biomass in an old-field ecosystem

    DEFF Research Database (Denmark)

    Blue, Jarrod D.; Souza, Lara; Classen, Aimée T.


    not be limiting primary production in this ecosystem. Insects reduced the aboveground biomass of subdominant plant species and decreased coarse root production. We found no statistical interactions between N availability and insect herbivory for any response variable. Overall, the results of 6 years of nutrient...

  8. Conversations About Responsible Nanoresearch. (United States)

    Kjølberg, Kamilla Lein; Strand, Roger


    There is currently a strong focus on responsible research in relation to the development of nanoscience and nanotechnology. This study presents a series of conversations with nanoresearchers, with the 'European Commission recommendation on a code of conduct for responsible nanosciences and nanotechnologies research' (EC-CoC) as its point of departure. Six types of reactions to the document are developed, illustrating the diversity existing within the scientific community in responses towards this kind of new approaches to governance. Three broad notions of responsible nanoresearch are presented. The article concludes by arguing that while the suggestion put forward in the EC-CoC brings the concept of responsible nanoresearch a long way, one crucial element is to be wanted, namely responsible nanoresearch as increased awareness of moral choices.

  9. Responsive aqueous foams. (United States)

    Fameau, Anne-Laure; Carl, Adrian; Saint-Jalmes, Arnaud; von Klitzing, Regine


    Remarkable properties have emerged recently for aqueous foams, including ultrastability and responsiveness. Responsive aqueous foams refer to foams for which the stability can be switched between stable and unstable states with a change in environment or with external stimuli. Responsive foams have been obtained from various foam stabilizers, such as surfactants, proteins, polymers, and particles, and with various stimuli. Different strategies have been developed to design this type of soft material. We briefly review the two main approaches used to obtain responsive foams. The first approach is based on the responsiveness of the interfacial layer surrounding the gas bubbles, which leads to responsive foams. The second approach is based on modifications that occur in the aqueous phase inside the foam liquid channels to tune the foam stability. We will highlight the most sophisticated approaches, which use light, temperature, and magnetic fields and lead to switchable foam stability. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Melatonin responsive hemicrania continua. (United States)

    Rozen, Todd D


    Hemicrania continua is one of the indomethacin-responsive headache syndromes. There are very few effective alternative therapies for hemicrania continua, thus patients may require daily indomethacin for years. The risks of long-term indomethacin include gastrointestinal and renal dysfunction. Melatonin is a pineal hormone with a chemical structure very similar to indomethacin. Recently, melatonin was shown to be effective for primary stabbing headache, another indomethacin-responsive syndrome. Three cases of melatonin responsive hemicrania continua are now reported.

  11. Biological response modifiers

    Energy Technology Data Exchange (ETDEWEB)

    Weller, R.E.


    Much of what used to be called immunotherapy is now included in the term biological response modifiers. Biological response modifiers (BRMs) are defined as those agents or approaches that modify the relationship between the tumor and host by modifying the host's biological response to tumor cells with resultant therapeutic effects.'' Most of the early work with BRMs centered around observations of spontaneous tumor regression and the association of tumor regression with concurrent bacterial infections. The BRM can modify the host response in the following ways: Increase the host's antitumor responses through augmentation and/or restoration of effector mechanisms or mediators of the host's defense or decrease the deleterious component by the host's reaction; Increase the host's defenses by the administration of natural biologics (or the synthetic derivatives thereof) as effectors or mediators of an antitumor response; Augment the host's response to modified tumor cells or vaccines, which might stimulate a greater response by the host or increase tumor-cell sensitivity to an existing response; Decrease the transformation and/or increase differentiation (maturation) of tumor cells; or Increase the ability of the host to tolerate damage by cytotoxic modalities of cancer treatment.

  12. GADRAS Detector Response Function.

    Energy Technology Data Exchange (ETDEWEB)

    Mitchell, Dean J.; Harding, Lee; Thoreson, Gregory G; Horne, Steven M.


    The Gamma Detector Response and Analysis Software (GADRAS) applies a Detector Response Function (DRF) to compute the output of gamma-ray and neutron detectors when they are exposed to radiation sources. The DRF is fundamental to the ability to perform forward calculations (i.e., computation of the response of a detector to a known source), as well as the ability to analyze spectra to deduce the types and quantities of radioactive material to which the detectors are exposed. This document describes how gamma-ray spectra are computed and the significance of response function parameters that define characteristics of particular detectors.

  13. Radiological Emergency Response Data (United States)

    U.S. Environmental Protection Agency — Quality Data Asset includes all current and historical emergency radiological response event and incident of national significance data and surveillance, monitoring,...

  14. Environmentally Responsible Aviation Project (United States)

    National Aeronautics and Space Administration — Created in 2009 as part of NASA's Aeronautics Research Mission Directorate's Integrated Systems Research Program, the Environmentally Responsible Aviation...

  15. Chemical Spill Response Manual

    NARCIS (Netherlands)

    Marieke Zeinstra; Wierd Koops


    A two year programme has been carried out by the NHL University of Applied Sciences together with private companies in the field of oil and chemical spill response to finalize these manuals on oil and chemical spill response. These manuals give a good overview of all aspects of oil and chemical

  16. Oil Spill Response Manual

    NARCIS (Netherlands)

    Sandra Heins; Marieke Zeinstra; Wierd Koops


    A two year programme has been carried out by the NHL University of Applied Sciences together with private companies in the field of oil and chemical spill response to finalize these manuals on oil and chemical spill response. These manuals give a good overview of all aspects of oil and chemical

  17. Collective Responsibility for Oppression

    NARCIS (Netherlands)

    Stahl, Titus


    Many contemporary forms of oppression are not primarily the result of formally organized collective action nor are they an unintended outcome of a combination of individual actions. This raises the question of collective responsibility. I argue that we can only determine who is responsible for

  18. On being responsible

    DEFF Research Database (Denmark)

    Davies, Sarah Rachael; Glerup, Cecilie; Horst, Maja


    as to enable innovation. To call for responsibility has, indeed, become somewhat trite. In this essay we take not the normative demand for responsibility, but its operationalisation, as our analytical focus, arguing that it is important not to underestimate the term’s practical flexibility and discursive...

  19. Response model parameter linking

    NARCIS (Netherlands)

    Barrett, M.L.D.


    With a few exceptions, the problem of linking item response model parameters from different item calibrations has been conceptualized as an instance of the problem of equating observed scores on different test forms. This thesis argues, however, that the use of item response models does not require

  20. Eastern Frequency Response Study

    Energy Technology Data Exchange (ETDEWEB)

    Miller, N.W.; Shao, M.; Pajic, S.; D' Aquila, R.


    This study was specifically designed to investigate the frequency response of the Eastern Interconnection that results from large loss-of-generation events of the type targeted by the North American Electric Reliability Corp. Standard BAL-003 Frequency Response and Frequency Bias Setting (NERC 2012a), under possible future system conditions with high levels of wind generation.

  1. Responsibilities and retention

    Directory of Open Access Journals (Sweden)

    Simon J Littlewood


    Full Text Available As our understanding of orthodontic relapse has improved, there is an increasing move toward long-term retention. Safely reducing relapse using appropriate long-term retention imposes considerable responsibilities on the orthodontist, the patient, and the patient's general dentist. This article will describe these responsibilities.

  2. UN assesses tsunami response

    Directory of Open Access Journals (Sweden)

    Marion Couldrey


    Full Text Available A report to the UN’s Economic and Social Council (ECOSOC identifies lessons learned from the humanitarian response. Recommendations stress the need for national ownership and leadership of disaster response and recovery, improved coordination, transparent use of resources, civil society engagement and greater emphasis on risk reduction.

  3. Responsive Space Program Brief

    Energy Technology Data Exchange (ETDEWEB)

    Dors, Eric E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)


    The goal of the Responsive Space program is to make significant, integrated science and technology contributions to the end-to-end missions of the U.S. Government that protect against global emerging and nuclear threats, from the earliest adversary planning through resilient event response report describes the LANL space program, mission, and other activities. The report describes some of their activities.

  4. Electrodermal Response in Gaming

    Directory of Open Access Journals (Sweden)

    J. Christopher Westland


    Full Text Available Steady improvements in technologies that measure human emotional response offer new possibilities for making computer games more immersive. This paper reviews the history of designs a particular branch of affective technologies that acquire electrodermal response readings from human subjects. Electrodermal response meters have gone through continual improvements to better measure these nervous responses, but still fall short of the capabilities of today's technology. Electrodermal response traditionally have been labor intensive. Protocols and transcription of subject responses were recorded on separate documents, forcing constant shifts of attention between scripts, electrodermal measuring devices and of observations and subject responses. These problems can be resolved by collecting more information and integrating it in a computer interface that is, by adding relevant sensors in addition to the basic electrodermal resistance reading to untangle (1 body resistance; (2 skin resistance; (3 grip movements; other (4 factors affecting the neural processing for regulation of the body. A device that solves these problems is presented and discussed. It is argued that the electrodermal response datastreams can be enriched through the use of added sensors and a digital acquisition and processing of information, which should further experimentation and use of the technology.

  5. Rangeland -- Plant responses to elevated CO sub 2

    Energy Technology Data Exchange (ETDEWEB)

    Owensby, C.E.; Coyne, P.I.; Ham, J.M.; Parton, W.; Rice, C.; Auen, L.M.; Adam, N.


    Several broad conclusions which can be drawn from the work that was accomplished during the first 3-year phase of the study is described. In prairie ecosystems dominated by C{sub 4} grasses, it is likely that elevated atmospheric CO{sub 2} will increase ecosystem level productivity, with a greater increase in belowground productivity. The increased productivity will primarily result from increased water use efficiency due to the anti-transpirant action of CO{sub 2}. Fumigation chambers are directly confounded with elevated CO{sub 2} effects, in that both reduce evapotranspiration. The reduced evapotranspiration of the fumigation chamber is primarily through reduced wind speeds and reduced radiation. In very dry years, fumigation chamber effects are negligible, but in years with normal precipitation, chamber effects and elevated CO{sub 2} effects are essentially equal with respect to reduced evapotranspiration effects. Increased production under elevated CO{sub 2} results in reduced nitrogen concentration in the herbage and increased fiber concentrations. Consequently, digestibility of the herbage is reduced, and microbial degradation of surface litter and soil organic matter is slowed. On the negative side, ruminant productivity will likely be reduced substantially, but increased carbon storage in the soil may buffer against future rise in atmospheric CO{sub 2}. Tallgrass prairie will not likely change greatly in botanical composition, since the C{sub 4} dominants responded to elevated CO{sub 2} more than the C{sub 3} subdominants.

  6. Geospatial Information Response Team (United States)

    Witt, Emitt C.


    Extreme emergency events of national significance that include manmade and natural disasters seem to have become more frequent during the past two decades. The Nation is becoming more resilient to these emergencies through better preparedness, reduced duplication, and establishing better communications so every response and recovery effort saves lives and mitigates the long-term social and economic impacts on the Nation. The National Response Framework (NRF) ( was developed to provide the guiding principles that enable all response partners to prepare for and provide a unified national response to disasters and emergencies. The NRF provides five key principles for better preparation, coordination, and response: 1) engaged partnerships, 2) a tiered response, 3) scalable, flexible, and adaptable operations, 4) unity of effort, and 5) readiness to act. The NRF also describes how communities, tribes, States, Federal Government, privatesector, and non-governmental partners apply these principles for a coordinated, effective national response. The U.S. Geological Survey (USGS) has adopted the NRF doctrine by establishing several earth-sciences, discipline-level teams to ensure that USGS science, data, and individual expertise are readily available during emergencies. The Geospatial Information Response Team (GIRT) is one of these teams. The USGS established the GIRT to facilitate the effective collection, storage, and dissemination of geospatial data information and products during an emergency. The GIRT ensures that timely geospatial data are available for use by emergency responders, land and resource managers, and for scientific analysis. In an emergency and response capacity, the GIRT is responsible for establishing procedures for geospatial data acquisition, processing, and archiving; discovery, access, and delivery of data; anticipating geospatial needs; and providing coordinated products and services utilizing the USGS' exceptional pool of

  7. Frequency Response Analysis Tool

    Energy Technology Data Exchange (ETDEWEB)

    Etingov, Pavel V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Kosterev, Dmitry [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Dai, T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)


    Frequency response has received a lot of attention in recent years at the national level, which culminated in the development and approval of North American Electricity Reliability Corporation (NERC) BAL-003-1 Frequency Response and Frequency Bias Setting Reliability Standard. This report is prepared to describe the details of the work conducted by Pacific Northwest National Laboratory (PNNL) in collaboration with the Bonneville Power Administration and Western Electricity Coordinating Council (WECC) Joint Synchronized Information Subcommittee (JSIS) to develop a frequency response analysis tool (FRAT). The document provides the details on the methodology and main features of the FRAT. The tool manages the database of under-frequency events and calculates the frequency response baseline. Frequency response calculations are consistent with frequency response measure (FRM) in NERC BAL-003-1 for an interconnection and balancing authority. The FRAT can use both phasor measurement unit (PMU) data, where available, and supervisory control and data acquisition (SCADA) data. The tool is also capable of automatically generating NERC Frequency Response Survey (FRS) forms required by BAL-003-1 Standard.

  8. State responsibility and counterterrorism

    National Research Council Canada - National Science Library

    Taylor, Isaac


    .... Yet, what each state is required to do in this project is unclear and contested. This article examines a number of bases on which we might assign responsibilities to conduct counterterrorist operations to states...

  9. Social Responsibility Instruments

    Directory of Open Access Journals (Sweden)

    Katarzyna Mizera


    Full Text Available Responsible business notion is more and more present in Polish economy, however the results of the research carried out in Polish business still shows a low level of CRS idea knowledge, especially in small and medium companies. Although responsible business notion is generally known, its details, ways of preparing strategy, instruments and what is more its benefits are still narrowly spread. Many business people face the lack of knowledge and information, which on one hand make it easier to spread and deepen wrong stereotypes connected with this notion and on the other hand make business people unwilling to implement CRS in their companies. The subjects of this article are examples of instruments which are responsible for realization of social responsibility strategy.

  10. Drones and Responsibility

    DEFF Research Database (Denmark)

    of different responsibility issues raised by military drones. The book discusses four main sets of questions: First, from a legal point of view, we analyse the ways in which the use of drones makes the attribution of criminal responsibility to individuals for war crimes more complicated and what adjustments...... may be required in international criminal law and in military practices to avoid ’responsibility gaps’ in warfare. From a moral and political perspective, the volume looks at the conditions under which the use of military drones by states is impermissible, permissible, or even obligatory and what...... our conception of agency and responsibility. The book will be of interest to scholars and students in (military) ethics and to those in law, politics and the military involved in the design, deployment and evaluation of military drones....

  11. Corporate Social Responsibility

    National Research Council Canada - National Science Library

    Suhaimi Ishak; Mohamad Naimi Mohamad Nor


    .... In Malaysia, based on the Malaysian Code on Corporate Governance (MCCG), (2007; 2012) clearly stated the role and responsibility of the board of directors toward the risk management activities...

  12. Consumer rights and responsibilities (United States)

    In March 1998, the Advisory Commission on Consumer Protection and Quality in the Health Care Industry issued its final report, which included the Consumer Bill of Rights and Responsibilities. The Commission was appointed ...

  13. OEM Emergency Response Information (United States)

    U.S. Environmental Protection Agency — The Office of Emergency Management retains records of all incident responses in which it participates. This data asset includes three major sources of information:...

  14. NOAA Emergency Response Imagery (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The imagery posted on this site is in response to natural disasters. The aerial photography missions were conducted by the NOAA Remote Sensing Division. The majority...

  15. Socially responsible investment engagement

    NARCIS (Netherlands)

    Goessling, T.; Buijter, Bas; Freeman, R.E.; Kujala, J.; Sachs, S.


    This study explores engagement in socially responsible investment (SRI) processes. More specifically, it researches the impact of shareholder salience on the success of engagement activities. The research question asks: What is the relationship between shareholder salience and engagement effort

  16. Responsive design high performance

    CERN Document Server

    Els, Dewald


    This book is ideal for developers who have experience in developing websites or possess minor knowledge of how responsive websites work. No experience of high-level website development or performance tweaking is required.

  17. Environmental Response Team (United States)

    This website will serve as a resource directory of the Environmental Response Team's roles and capabilities as well as list contacts for each discipline to provide information to EPA personnel and the public.

  18. Regional Response Teams (United States)

    There are thirteen in the U.S., each representing a geographic region (including the Caribbean and the Pacific Basin). Composed of representatives from field offices of the agencies that make up the National Response Team, and state representatives.

  19. Regional cholera response discussion

    CSIR Research Space (South Africa)

    Funke, Nicola S


    Full Text Available research questions identified by the CSIR on cholera as a trans- or cross-border communicable disease that requires complex interventions in terms of preparedness and response, management, prevention and mitigation. The workshop commenced with a...

  20. Space race functional responses

    National Research Council Canada - National Science Library

    Sjödin, Henrik; Brännström, Åke; Englund, Göran


    We derive functional responses under the assumption that predators and prey are engaged in a space race in which prey avoid patches with many predators and predators avoid patches with few or no prey...

  1. Adrenal Responses to Stress


    Goldstein, David S.


    Based on concepts proposed by Langley, Cannon, and Selye, adrenal responses to stress occur in a syndrome that reflects activation of the sympathoadrenal system and hypothalamic–pituitary–adrenocortical (HPA) axis; and a “stress syndrome” maintains homeostasis in emergencies such as “fight or flight” situations, but if the stress response is excessive or prolonged then any of a variety of clinical disorders can arise. The idea of a unitary sympathoadrenal system does not account for evidence ...

  2. National Response Framework (United States)


    version of the NRF and implements the new requirements and terminology of PPD-8. By fostering a holistic approach to response, this NRF emphasizes the... history of emergency management and the distilled wisdom of responders and leaders across the whole community. Engaged Partnership Effective...emergency responders, and access to community staples (e.g., grocery stores, pharmacies , and banks) and fire and other first response services. Critical

  3. Pathological responses to terrorism. (United States)

    Yehuda, Rachel; Bryant, Richard; Marmar, Charles; Zohar, Joseph


    Many important gains have been made in understanding PTSD and other responses to trauma as a result of neuroscience-based observations. Yet there are many gaps in our knowledge that currently impede our ability to predict those who will develop pathologic responses. Such knowledge is essential for developing appropriate strategies for mounting a mental health response in the aftermath of terrorism and for facilitating the recovery of individuals and society. This paper reviews clinical and biological studies that have led to an identification of pathologic responses following psychological trauma, including terrorism, and highlights areas of future-research. It is important to not only determine risk factors for the development of short- and long-term mental health responses to terrorism, but also apply these risk factors to the prediction of such responses on an individual level. It is also critical to consider the full spectrum of responses to terrorism, as well as the interplay between biological and psychological variables that contribute to these responses. Finally, it is essential to remove the barriers to collecting data in the aftermath of trauma by creating a culture of education in which the academic community can communicate to the public what is and is not known so that survivors of trauma and terrorism will understand the value of their participation in research to the generation of useful knowledge, and by maintaining the acquisition of knowledge as a priority for the government and those involved in the immediate delivery of services in the aftermath of large-scale disaster or trauma.

  4. Advances in Crash Response

    Centers for Disease Control (CDC) Podcasts


    In this podcast, Dr. Richard C. Hunt, Director of CDC's Division of Injury Response, provides an overview on the benefits of using an Advanced Automatic Collision Notification system, or AACN, to help with emergency triage of people injured in vehicle crashes.  Created: 6/29/2009 by National Center for Injury Prevention and Control (NCIPC), Division of Injury Response (DIR).   Date Released: 6/29/2009.


    Directory of Open Access Journals (Sweden)



    Full Text Available The violation of a social norm establishing a rule of conduct engages the violator’s liability. Responsibility is a social phenomenon and it expresses, in its shortest definition, an act of commitment of the individual in the process of social interaction. This study aims to analyze the concepts of liability and responsibility, but also the relationship between them, starting from their common fundamentals and ending with the main differences between the two notions.

  6. Auxin response factors. (United States)

    Chandler, John William


    Auxin signalling involves the activation or repression of gene expression by a class of auxin response factor (ARF) proteins that bind to auxin response elements in auxin-responsive gene promoters. The release of ARF repression in the presence of auxin by the degradation of their cognate auxin/indole-3-acetic acid repressors forms a paradigm of transcriptional response to auxin. However, this mechanism only applies to activating ARFs, and further layers of complexity of ARF function and regulation are being revealed, which partly reflect their highly modular domain structure. This review summarizes our knowledge concerning ARF binding site specificity, homodimer and heterodimer multimeric ARF association and cooperative function and how activator ARFs activate target genes via chromatin remodelling and evolutionary information derived from phylogenetic comparisons from ARFs from diverse species. ARFs are regulated in diverse ways, and their importance in non-auxin-regulated pathways is becoming evident. They are also embedded within higher-order transcription factor complexes that integrate signalling pathways from other hormones and in response to the environment. The ways in which new information concerning ARFs on many levels is causing a revision of existing paradigms of auxin response are discussed. © 2016 John Wiley & Sons Ltd.

  7. Enviromental responsability and corporate social responsability

    Directory of Open Access Journals (Sweden)

    Jesús Marí Farinós


    Full Text Available The environmental management of companies and organizations in general is going to be internalized in the operation and management structures, linking conceptual and chronologically to improve corporate reputation, management excellence, knowledge and innovation. Embracing, undoubtedly too, with the assumption of an ethical commitment of the company to society: environmental sustainability and generational solidarity in the transmission of culture and values of that nature. The existing need to know the potential impact of business operations on society and the environment results in the appearance of a document, which may well be called a Sustainability Report or Social Balance, which is compiled from a series social indicators, which are the instruments responsible to reflect the value of the shares held by the company in social and environmental fields.

  8. Decoupling Responsible Management Education

    DEFF Research Database (Denmark)

    Rasche, Andreas; Gilbert, Dirk Ulrich


    to responsible management education with their limited internal capacity for change. Our analysis proposes that decoupling is likely if schools (a) are exposed to resource stringency, (b) face overt or covert resistance against change processes, (c) are confronted with competing institutional pressures, and (d......This article examines under what conditions business schools may decouple the structural effects of their engagement in responsible management education from actual organizational practices. We argue that schools may be unable to match rising institutional pressures to publicly commit......) perceive institutional demands as ambiguous. We discuss two implications of this proposition. On one hand, decoupling can cause dissonant legitimacy perceptions, leading to cynicism around responsible management education within business schools. On the other hand, a temporary inconsistency between talk...

  9. Photovoltaic spectral responsivity measurements

    Energy Technology Data Exchange (ETDEWEB)

    Emery, K.; Dunlavy, D.; Field, H.; Moriarty, T. [National Renewable Energy Lab., Golden, CO (United States)


    This paper discusses the various elemental random and nonrandom error sources in typical spectral responsivity measurement systems. The authors focus specifically on the filter and grating monochrometer-based spectral responsivity measurement systems used by the Photovoltaic (PV) performance characterization team at NREL. A variety of subtle measurement errors can occur that arise from a finite photo-current response time, bandwidth of the monochromatic light, waveform of the monochromatic light, and spatial uniformity of the monochromatic and bias lights; the errors depend on the light source, PV technology, and measurement system. The quantum efficiency can be a function of he voltage bias, light bias level, and, for some structures, the spectral content of the bias light or location on the PV device. This paper compares the advantages and problems associated with semiconductor-detector-based calibrations and pyroelectric-detector-based calibrations. Different current-to-voltage conversion and ac photo-current detection strategies employed at NREL are compared and contrasted.

  10. The integrated stress response. (United States)

    Pakos-Zebrucka, Karolina; Koryga, Izabela; Mnich, Katarzyna; Ljujic, Mila; Samali, Afshin; Gorman, Adrienne M


    In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α) by one of four members of the eIF2α kinase family, which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. The gene expression program activated by the ISR optimizes the cellular response to stress and is dependent on the cellular context, as well as on the nature and intensity of the stress stimuli. Although the ISR is primarily a pro-survival, homeostatic program, exposure to severe stress can drive signaling toward cell death. Here, we review current understanding of the ISR signaling and how it regulates cell fate under diverse types of stress. © 2016 The Authors.

  11. Adaptive response modelling (United States)

    Campa, Alessandro; Esposito, Giuseppe; Belli, Mauro

    Cellular response to radiation is often modified by a previous delivery of a small "priming" dose: a smaller amount of damage, defined by the end point being investigated, is observed, and for this reason the effect is called adaptive response. An improved understanding of this effect is essential (as much as for the case of the bystander effect) for a reliable radiation risk assessment when low dose irradiations are involved. Experiments on adaptive response have shown that there are a number of factors that strongly influence the occurrence (and the level) of the adaptation. In particular, priming doses and dose rates have to fall in defined ranges; the same is true for the time interval between the delivery of the small priming dose and the irradiation with the main, larger, dose (called in this case challenging dose). Different hypotheses can be formulated on the main mechanism(s) determining the adaptive response: an increased efficiency of DNA repair, an increased level of antioxidant enzymes, an alteration of cell cycle progression, a chromatin conformation change. An experimental clearcut evidence going definitely in the direction of one of these explanations is not yet available. Modelling can be done at different levels. Simple models, relating the amount of damage, through elementary differential equations, to the dose and dose rate experienced by the cell, are relatively easy to handle, and they can be modified to account for the priming irradiation. However, this can hardly be of decisive help in the explanation of the mechanisms, since each parameter of these models often incorporates in an effective way several cellular processes related to the response to radiation. In this presentation we show our attempts to describe adaptive response with models that explicitly contain, as a dynamical variable, the inducible adaptive agent. At a price of a more difficult treatment, this approach is probably more prone to give support to the experimental studies

  12. Socially responsible investing

    Directory of Open Access Journals (Sweden)

    Krstić Nataša


    Full Text Available Socially responsible investing, as an investment strategy which seeks to consider both the increase of an investment's financial returns and the achievement of certain social goals, today is a global phenomenon and one of the strongest trends in socially responsible business. Its ultimate result is that shareholders and investors have the discretionary power to force companies to become more attentive and dedicated to the treatment of social, environmental and ethical problems and principles, thereby realizing their potential to change not only a particular industry, but the entire economy as well.

  13. Luxury organizations and responsibility

    DEFF Research Database (Denmark)

    Montesa, Farah; Rohrbeck, René


    In this article, findings from previous research, almost forty examples of responsible practices in luxury firms, were clustered and eight generic tools were revealed to advance sustainability. These tools are posed as questions to assess the luxury firm’s level of sustainability and to plan...

  14. Response to Intervention Effectiveness (United States)

    Mulholland, Stephanie L.


    The intersection of No Child Left Behind (2002) and the reauthorization of the Individuals with Disabilities Education Act (2004) made it necessary for educators to examine achievement trends within their schools and implement a Response to Intervention (RTI) program. This study examines the achievement trends in one school district since its…

  15. Vestibulo-Sympathetic Responses (United States)

    Yates, Bill J; Bolton, Philip S.; Macefield, Vaughan G.


    Evidence accumulated over 30 years, from experiments on animals and human subjects, has conclusively demonstrated that inputs from the vestibular otolith organs contribute to the control of blood pressure during movement and changes in posture. This review considers the effects of gravity on the body axis, and the consequences of postural changes on blood distribution in the body. It then separately considers findings collected in experiments on animals and human subjects demonstrating that the vestibular system regulates blood distribution in the body during movement. Vestibulosympathetic reflexes differ from responses triggered by unloading of cardiovascular receptors such as baroreceptors and cardiopulmonary receptors, as they can be elicited before a change in blood distribution occurs in the body. Dissimilarities in the expression of vestibulosympathetic reflexes in humans and animals are also described. In particular, there is evidence from experiments in animals, but not humans, that vestibulosympathetic reflexes are patterned, and differ between body regions. Results from neurophysiological and neuroanatomical studies in animals are discussed that identify the neurons that mediate vestibulosympathetic responses, which include cells in the caudal aspect of the vestibular nucleus complex, interneurons in the lateral medullary reticular formation, and bulbospinal neurons in the rostral ventrolateral medulla (RVLM). Recent findings showing that cognition can modify the gain of vestibulosympathetic responses are also presented, and neural pathways that could mediate adaptive plasticity in the responses are proposed, including connections of the posterior cerebellar vermis with the vestibular nuclei and brainstem nuclei that regulate blood pressure. PMID:24715571

  16. Whistleblowing & Professional Responsibilities. (United States)

    Professional Engineer, 1979


    Discussed are the moral dilemmas encountered daily by professionals and how the teaching of ethics may help resolve the conflicts individuals face with respect to whistleblowing. Included are consideration of responsibilities, role of ethics codes, and courses on professional ethics. (CS)

  17. Energy-responsive timekeeping

    Indian Academy of Sciences (India)

    ... with genetic regulators of metabolism, and are directly responsive to cellular energy supply. This close interaction is likely to be critical for normal circadian regulation of metabolism, and may also underlie the disruption of proper metabolic rhythms observed in metabolic disorders, such as obesity and type-II diabetes.

  18. Decoupling Responsible Management Education

    DEFF Research Database (Denmark)

    Rasche, Andreas; Gilbert, Dirk Ulrich

    stringency, (2) face overt or covert resistance against change processes, (3) are confronted with competing institutional pressures, and (4) perceive institutional demands as ambiguous. The discussion points to two implications. While decoupling may give rise to the illusion that responsible management...

  19. Lithium response across generations. (United States)

    Grof, P; Duffy, A; Alda, M; Hajek, T


    To describe and integrate observations from bipolar patients responsive to lithium stabilization and their children. Selected findings are described from the clinical and biological investigations of adults meeting research criteria for bipolar disorder and for responsiveness to lithium stabilization; and from prospective studies of the children of lithium responders and non-responders. Response to prophylactic lithium identifies a valid subtype of bipolar disorder, however the search for biological markers of lithium response, while promising, has so far remained inconclusive. Adult responders to lithium stabilization exhibit definable clinical features which are also observable in their affected children. In prospective studies the children of bipolar parents develop symptoms earlier than reported previously, with marked differences between the offspring of lithium responders and non-responders. The illness evolves in predictable clinical stages, first from non-specific sleep and anxiety disorders to mood symptoms and then, often starting in adolescence, major depressive and later activated episodes. Investigating and comparing unequivocal responders and non-responders to long-term lithium treatment and their offspring is a fertile research strategy for addressing a multitude of clinical and research questions.

  20. Corporate Social Responsibility

    African Journals Online (AJOL)

    business ethics. The logical supposition was that the multinationals spreading destructive externalities could have a converse ability to mitigate their damages and make positive contributions within their areas of operation. Models of corporate social responsibility (CSR) and new global business standards became.

  1. Response to Mackenzie (United States)

    Peers, Chris


    Chris Peers begins his response to Jim Mackenzie's article, "Peers on Socrates and Plato" by asking "What is the 'masculine imaginary?'" Peers defines the term "imaginary" as it is applied in his article, "Freud, Plato and Irigaray: A Morpho-Logic of Teaching and Learning" (2012) and draws…

  2. Environmentally responsive graphene systems. (United States)

    Zhang, Jing; Song, Long; Zhang, Zhipan; Chen, Nan; Qu, Liangti


    Graphene materials have been attracting significant research interest in the past few years, with the recent focuses on graphene-based electronic devices and smart stimulus-responsive systems that have a certain degree of automatism. Owing to its huge specific surface area, large room-temperature electron mobility, excellent mechanical flexibility, exceptionally high thermal conductivity and environmental stability, graphene is identified as a beneficial additive or an effective responding component by itself to improve the conductivity, flexibility, mechanical strength and/or the overall responsive performance of smart systems. In this review article, we aim to present the recent advances in graphene systems that are of spontaneous responses to external stimulations, such as environmental variation in pH, temperature, electric current, light, moisture and even gas ambient. These smart stimulus-responsive graphene systems are believed to have great theoretical and practical interests to a wide range of device applications including actuators, switches, robots, sensors, drug/gene deliveries, etc. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.




  4. Definitions of social responsibility

    NARCIS (Netherlands)

    Planken, B.C.


    The role of Corporate Social Responsibility in the business world has developed from a fig leaf marketing front into an important aspect of corporate behavior over the past several years. Sustainable strategies are valued, desired and deployed more and more by relevant players in many industries all

  5. The Responsive Global Organization

    DEFF Research Database (Denmark)

    Andersen, Torben Juul


    The global business context is turbulent and becoming a dynamic complex system where small events can trigger large outcomes that are difficult to predict. This gives urgency to the search for responsive global organizations that are able to adapt the multinational corporate strategy so it provides...

  6. Senescence responsive transcriptional element (United States)

    Campisi, Judith; Testori, Alessandro


    Recombinant polynucleotides have expression control sequences that have a senescence responsive element and a minimal promoter, and which are operatively linked to a heterologous nucleotide sequence. The molecules are useful for achieving high levels of expression of genes in senescent cells. Methods of inhibiting expression of genes in senescent cells also are provided.

  7. Test Fairness: A Response (United States)

    Davies, Alan


    This article presents the author's response to Xiaoming Xi's paper titled "How do we go about investigating test fairness?" In the paper, Xi offers "a means to fully integrate fairness investigations and practice". Given the current importance accorded to fairness in the language testing community, Xi makes a case for viewing fairness as an aspect…

  8. Power and responsibility

    NARCIS (Netherlands)

    Nollkaemper, A.


    This paper critically reviews the popular proposition that 'power breeds responsibility'. It first explains why this proposition is intuitively appealing. Particularly in situations where multiple actors contribute to harm, power can be a criterion for determining who of a multitude of actors should

  9. Randomized response methods

    NARCIS (Netherlands)

    van der Heijden, P.G.M.; Cruyff, Maarten; Bockenholt, U.


    In survey research it is often problematic to ask people sensitive questions because they may refuse to answer or they may provide a socially desirable answer that does not reveal their true status on the sensitive question. To solve this problem Warner (1965) proposed randomized response (RR). Here

  10. DNA damage response

    NARCIS (Netherlands)

    G. Giglia-Mari (Giuseppina); A. Zotter (Angelika); W. Vermeulen (Wim)


    textabstractStructural changes to DNA severely affect its functions, such as replication and transcription, and play a major role in age-related diseases and cancer. A complicated and entangled network ofDNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance

  11. Corporate social responsibility

    Directory of Open Access Journals (Sweden)

    Arsić Zoran


    Full Text Available Corporate Social Responsibility (CSR is a concept whereby companies integrate social and environmental concerns in their business operations and in their interaction with their stakeholders on a voluntary basis. Definition emphasizes three basic characteristics of CSR. CSR is voluntary concept, it covers environmental issues and interaction with stakeholders, not only shareholders, is taken into account.

  12. Businesses’ human rights responsibilities

    Directory of Open Access Journals (Sweden)

    Corinne Lewis


    Full Text Available There is no international human rights law standard that expresslyprohibits businesses’ arbitrary displacement of persons. Businessesdo, however, have the responsibility to avoid infringements of humanrights that could lead to displacement and also to take actions toremedy their human rights violations that might lead to displacement.

  13. Socially responsible firms

    NARCIS (Netherlands)

    Ferrell, A.; Liang, Hao; Renneboog, Luc


    In the corporate finance tradition, starting with Berle and Means (1932), corporations should generally be run to maximize shareholder value. The agency view of corporate social responsibility (CSR) considers CSR an agency problem and a waste of corporate resources. Given our identification strategy

  14. Socially Responsible Firms

    NARCIS (Netherlands)

    Renneboog, L.D.R.; Liang, H.; Ferrell, A.


    In the corporate finance tradition starting with Berle & Means (1923), corporations should generally be run so as to maximize shareholder value. The agency view of corporate social responsibility (CSR) generally considers CSR as a managerial agency problem and a waste of corporate resources, since

  15. Critical Response Protocol (United States)

    Ellingson, Charlene; Roehrig, Gillian; Bakkum, Kris; Dubinsky, Janet M.


    This article introduces the Critical Response Protocol (CRP), an arts-based technique that engages students in equitable critical discourse and aligns with the "Next Generation Science Standards" vision for providing students opportunities for language learning while advancing science learning (NGSS Lead States 2013). CRP helps teachers…

  16. Rethinking Moral Responsibility

    NARCIS (Netherlands)

    Vedder, A.H.; Johnson, D.; Moor, J.; Tavani, H.


    Questions regarding the moral responsibility of Internet access and service providers relating to possible negative aspects of information on the Internet call for a reassessment of the ways in which we think about attributing blame, guilt, and duties of reparation and compensation. They invite us

  17. Modeling of Responses and Response Times with the Package CIRT

    NARCIS (Netherlands)

    Fox, Gerardus J.A.; Klein Entink, R.H.; van der Linden, Willem J.


    In computerized testing, the test takers' responses as well as their response times on the items are recorded. The relationship between response times and response accuracies is complex and varies over levels of observation. For example, it takes the form of a tradeoff between speed and accuracy at

  18. Responsible conduct of research

    CERN Document Server

    Shamoo, Adil E


    Since the early 2000s, the field of Responsible Conduct of Research has become widely recognized as essential to scientific education, investigation, and training. At present, research institutions with public funding are expected to have some minimal training and education in RCR for their graduate students, fellows and trainees. These institutions also are expected to have a system in place for investigating and reporting misconduct in research or violations of regulations in research with human subjects, or in their applications to federal agencies for funding. Public scrutiny of the conduct of scientific researchers remains high. Media reports of misconduct scandals, biased research, violations of human research ethics rules, and moral controversies in research occur on a weekly basis. Since the 2009 publication of the 2nd edition of Shamoo and Resnik's Responsible Conduct of Research, there has been a vast expansion in the information, knowledge, methods, and diagnosis of problems related to RCR and the ...

  19. Aesthetic responses to music

    DEFF Research Database (Denmark)

    Istok, Eva; Brattico, Elvira; Jacobsen, Thomas


    , the adjective "touching" was often listed together with "beautiful". In addition, we found music-specific vocabulary as well as adjectives related to emotions and mood states indicating that affective processes are an essential part of aesthetic responses to music. Differences between music experts and laymen......We explored the content and structure of the cognitive, knowledge-based concept underlying aesthetic responses to music. To this aim, we asked 290 Finnish students to verbally associate the aesthetic value of music and to write down a list of appropriate adjectives within a given time limit....... No music was presented during the task. In addition, information about participants' musical background was collected. A variety of analysis techniques was used to determine the key results of our study. The adjective "beautiful" proved to be the core item of the concept under question. Interestingly...

  20. Corporate Social Responsibility

    DEFF Research Database (Denmark)

    Liempd, Dennis van; Warming-Rasmussen, Bent; Abild-Nielsen, Jens


    Målet med denne artikel er at klargøre, at der findes forskellige teoretiske tilgange til ansvarlig leverandørstyring og Corporate Social Responsibility (i det følgende kaldt CSR). Endvidere er det målet at belyse, at området er i kraftig udvikling og forventes at få øget betydning for revisor i...... ansvarlig leverandørstyring og CSR. I artiklen konkluderes følgende: - at udviklingen i Corporate Social Responsibility indikerer, at etik er den mest betydende faktor (driver); (jf. afsnit 1)- at etik som primær driver vil betyde, at virksomheden vil gå ud over lovens minimumkrav, og stræbe efter de...

  1. Probing human response times (United States)

    Johansen, Anders


    In a recent preprint (Dialog in e-mail traffic, preprint cond-mat/0304433), the temporal dynamics of an e-mail network has been investigated by Eckmann, Moses and Sergi. Specifically, the time period between an e-mail message and its reply were recorded. It will be shown here that their data agrees quantitatively with the frame work proposed to explain a recent experiment on the response of “internauts” to a news publication (Physica A 296(3-4) (2001) 539) despite differences in communication channels, topics, time-scale and socio-economic characteristics of the two population. This suggest a generalized response time distribution ∼ t-1 for human populations in the absence of deadlines with important implications for psychological and social studies as well the study of dynamical networks.

  2. Hematologic Response to Exercise

    Directory of Open Access Journals (Sweden)

    Javier Fernando Bonilla Briceño


    Full Text Available Moderate to intensive physical exercisegenerates different types of response in an individual.These responses depend upon the typeof exercise and the duration of it, and they canbe acute or chronic. Exercise affects differentcorporal system, among those is the hematologicalsystem. Literature describes changes inthe blood volume, changes in the activity andpopulation of white blood cells, as well asmodifications in the humoral and cellularimmunity, and in the count and shape of bloodplatelets. Also and as a result of those changes, ithas been determined too, that exercise modifiesin a negative way the life time of red blood cells,generating an apparent anemia, that has beenwidely discuss and that might be, among manyfactors, associated to hemolysis. This hemolysismight be associated with osmotic mechanismsor oxidative stress. The true is that all thoseevents are strongly related and may cause a lowperformance in the practice of any physicalactivity, including that of sportsmen.

  3. Structural response synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Ozisik, H.; Keltie, R.F.


    The open loop control technique of predicting a conditioned input signal based on a specified output response for a second order system has been analyzed both analytically and numerically to gain a firm understanding of the method. Differences between this method of control and digital closed loop control using pole cancellation were investigated as a follow up to previous experimental work. Application of the technique to diamond turning using a fast tool is also discussed.

  4. Chinas Response to Terrorism (United States)


    unable to write their names in Mandarin. The paper contended that this language barrier , coupled with poverty and “enthusiasm for religion,” made this...important responsibilities for counterterrorism policy, and provide a venue that can help overcome bureaucratic barriers and coordinate and guide...345 Minnie Chan, “Mainland’s Elite Forces Go through ’ Hell ’ to Prepare for War against Terror

  5. Ocular Response Analyzer


    Kaushik, Sushmita; Pandav, Surinder Singh


    Until recently, corneal biomechanical properties could not be measured in vivo. The ocular response analyzer is a new, noninvasive device that analyses corneal biomechanical properties simply and rapidly. The ORA allows cornea compensated IOP measurements and can estimate corneal hysteresis (CH) and corneal resistance factor (CRF). It is designed to improve the accuracy of IOP measurement by using corneal biomechanical data to calculate a biomechanically adjusted estimate of intraocular press...

  6. Operationally Responsive Tasking (United States)


    RESPONSIVE TASKING by Aaron C. Bass September 2011 Thesis Advisor: Alan D. Scott Second Reader: Mark Rhoades THIS PAGE INTENTIONALLY LEFT...September 2011 Author: Aaron C. Bass Approved by: Alan D. Scott Thesis Advisor Mark M. Rhoades Second Reader [34] D. Pizzocaro, M. Johnson, H. Rowaihy, S. Chalmers , A. Preece, A. Bar- Noy, and T. La Porta, “A Knapsack

  7. Cell response to surgery.

    LENUS (Irish Health Repository)

    Ni Choileain, Niamh


    OBJECTIVES: To describe the profound alterations in host immunity that are produced by major surgery as demonstrated by experimental and clinical studies, and to evaluate the benefits of therapeutic strategies aimed at attenuating perioperative immune dysfunction. DATA SOURCES: A review of the English-language literature was conducted, incorporating searches of the MEDLINE, EMBASE, and Cochrane collaboration databases to identify laboratory and clinical studies investigating the cellular response to surgery. STUDY SELECTION: Original articles and case reports describing immune dysfunction secondary to surgical trauma were included. DATA EXTRACTION: The results were compiled to show outcomes of different studies and were compared. DATA SYNTHESIS: Current evidence indicates that the early systemic inflammatory response syndrome observed after major surgery that is characterized by proinflammatory cytokine release, microcirculatory disturbance, and cell-mediated immune dysfunction is followed by a compensatory anti-inflammatory response syndrome, which predisposes the patient to opportunistic infection, multiple organ dysfunction syndrome, and death. Because there are currently no effective treatment options for multiple organ dysfunction syndrome, measures to prevent its onset should be initiated at an early stage. Accumulating experimental evidence suggests that targeted therapeutic strategies involving immunomodulatory agents such as interferon gamma, granulocyte colony-stimulating factor, the prostaglandin E(2) antagonist, indomethacin, and pentoxifylline may be used for the treatment of systemic inflammatory response syndrome to prevent the onset of multiple organ dysfunction syndrome. CONCLUSIONS: Surgical trauma produces profound immunological dysfunction. Therapeutic strategies directed at restoring immune homeostasis should aim to redress the physiological proinflammatory-anti-inflammatory cell imbalance associated with major surgery.

  8. Prediction of flap response. (United States)

    Potgieter, Frederik J; Roberts, Cynthia; Cox, Ian G; Mahmoud, Ashraf M; Herderick, Edward E; Roetz, Marlize; Steenkamp, Wouter


    To find predictors of the induced biomechanical and optical effects of lamellar flap creation on the cornea. Optimed Eye and Laser Clinic, Pretoria, South Africa, and the Department of Ophthalmology and Biomedical Engineering Center, The Ohio State University, Columbus, Ohio, and Bausch & Lomb Vision Research Laboratory, Rochester, New York, USA. This prospective study monitored the refractive, wavefront aberration, and corneal topographic changes in 29 eyes of 15 patients for 3 months after the creation of a corneal lamellar flap. The main outcome measures for statistical analysis were refraction, total corneal thickness, residual corneal bed thickness, horizontal white-to-white corneal diameter, horizontal flap diameter, topography data, and wavefront data. Statistically significant changes were seen in the autorefraction mode. Wavefront data showed significant change in 4 Zernike modes-90/180-degree astigmatism, vertical coma, horizontal coma, and spherical aberration. The topography data indicated the corneal biomechanical response was significantly predicted by stromal bed thickness in the early follow-up period and by total corneal pachymetry and flap diameter in a 2-parameter statistical model in the late follow-up period. Uncomplicated lamellar flap creation is responsible for systematic changes in corneal topography and induction of higher-order optical aberrations. Predictors of this response include stromal bed thickness, flap diameter, and total corneal pachymetry.

  9. Load responsive hydrodynamic bearing (United States)

    Kalsi, Manmohan S.; Somogyi, Dezso; Dietle, Lannie L.


    A load responsive hydrodynamic bearing is provided in the form of a thrust bearing or journal bearing for supporting, guiding and lubricating a relatively rotatable member to minimize wear thereof responsive to relative rotation under severe load. In the space between spaced relatively rotatable members and in the presence of a liquid or grease lubricant, one or more continuous ring shaped integral generally circular bearing bodies each define at least one dynamic surface and a plurality of support regions. Each of the support regions defines a static surface which is oriented in generally opposed relation with the dynamic surface for contact with one of the relatively rotatable members. A plurality of flexing regions are defined by the generally circular body of the bearing and are integral with and located between adjacent support regions. Each of the flexing regions has a first beam-like element being connected by an integral flexible hinge with one of the support regions and a second beam-like element having an integral flexible hinge connection with an adjacent support region. A least one local weakening geometry of the flexing region is located intermediate the first and second beam-like elements. In response to application of load from one of the relatively rotatable elements to the bearing, the beam-like elements and the local weakening geometry become flexed, causing the dynamic surface to deform and establish a hydrodynamic geometry for wedging lubricant into the dynamic interface.

  10. Risk and responsibility

    Energy Technology Data Exchange (ETDEWEB)

    Leiss, W.; Chociolko, C.


    Management of health and environmental risks and the disagreements from industry, government, and environmental activist points of view were discussed. A definition of risk and risk management theory were introduced. The apportioning of responsibility was discussed. The manner in which individuals and organizations secure benefits to themselves, and off-load responsibility for the risks to someone else, to some other segment of society, or to the public at large, was explained and demonstrated by examples from various walks of life. Obstacles to arriving at consensus were examined at length, illustrated by the seemingly intractable controversies surrounding power frequency electric and magnetic fields. Potential solutions discussed included as prime prerequisite the acceptance of the notion that risks are trade-offs, i.e. to take risks is to incur a certain loss in expectation of a larger, but uncertain, offsetting gain. An equally important notion that was at the centre of a possible solution was the recognition of the indivisible duality of risk-taking and the generation of trade-offs. Risk management theories, including apportioning responsibility through negotiated consensus, and the role of experts,were discussed in detail. 9 figs., 18 tabs., 231 refs.

  11. Temperature responsive cooling apparatus

    Energy Technology Data Exchange (ETDEWEB)

    Weker, M.L.; Stearns, R.M.


    A temperature responsive cooling apparatus is described for an air conditioner or refrigeration system in operative association with a reservoir of fluid, the air conditioner or refrigeration system having an air cooled coil and means for producing a current of air for cooling the coil, the temperature responsive cooling apparatus comprising: (a) means for transferring the fluid from the reservoir to the air conditioner temperature responsive cooling apparatus, (b) a fluid control device activated by the current of air for cooling the coil; (c) a temperature activated, nonelectrical device for terminating and initiating the flow of fluid therethrough in an intermittent fashion for enhancing the operability of the compressor associated with the refrigeration system and for reducing the quantity of fluid required to cool the coil of the refrigeration system, (d) a fluid treatment device for preventing, reducing or mitigating the deposition of nonevaporative components on the air cooled coil, and (e) means for dispersing the fluid to the air cooled coil from the fluid control device for cooling the coil and increasing the efficiency of the air conditioner thereby reducing the cost of operating and maintaining the air conditioner without damaging the air conditioner and without the deposition of nonevaporative components thereupon.


    Directory of Open Access Journals (Sweden)

    Hatib A. Kadir


    Full Text Available Sociological discussion of globalisation is preoccupied with the political, economic, and military dimension of it, with little attention to its religious aspect. This paper attempts to trace the impacts of globalisation on religion and religious responses, the argument of which derives mainly from the so-called “Bridge-Building Program” organised by CRCS & ICRS-UGM in 2008. It argues that though they share a common concern, people of different faiths are at risk of deepening the problems rather than offering solutions in view of their different responses for which we categorise them into different but overlapping categories -ideological, ambivalent, integrative, exclusive, and imitative. It then leads to a more fundamental question of whether interfaith cooperation is possible given those different and sometime opposing responses. [Dalam kajian sosiologi, diskusi mengenai globalisasi kerap kali semata-mata ditinjau dari sisi politik, enonomi dan militer, sementara dimensi agama sering kali dikesampingkan. Artikel ini membahas dampak globalisasi terhadap agama dan respon komunitas agama terhadap globalisasi. Data yang muncul dalam artikel ini diambil dari sebuah workshop berjudul“Bridge- Building Program.” Melalui artikel ini, saya berpendapat bahwa, meskikomunitas agama-agama memiliki keprihatinan yang sama terhadap dampak globalisasi, namun respon mereka cenderung mempertajam persoalan yang diakibatkan globalisasi, ketimbang memberikan solusi. Respon tersebut dalam dikategorikan –meski tidak kaku- dalam: respon ideologis, ambivalen, integratif, ekslusif dan imitatif. Selanjutnya, artikel juga mengulas pada pertanyaan mendasar mengenai apakah kerjasama antar agama mungkin dilakukan menyimak ragam respon yang saling bertentangan tersebut.

  13. Crisis response to schools. (United States)

    Johnson, K


    While community based crisis response teams offer needed resources to schools impacted by crisis, they are often not asked to help. Reports from crisis team leaders at the school shooting incidents at James W. Parker Middle School, Edinboro, Pennsylvania and Columbine High School, Littleton, Colorado are contrasted regarding utilization of community resources. Factors limiting the usefulness of community based teams include unfamiliarity with school organization, culture, and procedures. Key differences in school vs. community team precepts, decision-making, and strategic paradigms render team coordination difficult. Successful cross training presents opportunities for school-community partnership and utilization of community teams for school duty.

  14. Community response to noise

    Directory of Open Access Journals (Sweden)

    Takashi Yano


    Full Text Available Activities from 2008 to 2011 by ICBEN community response to noise team were summarized. That is, individual community-based indexes such as community tolerance Level, Zuricher Fluglarm Index (ZFI and Frankfurter Fluglarm Index (FFI/FNI were newly proposed, differences in railway bonus between Europe and Asia were discussed by a Swedish survey, socio-acoustic surveys were reported from developing countries, and annoyance equivalents and dominant source models were proposed as the adequate combined noise model. Furthermore, not only negative, but also positive aspects of sound were discussed as soundscape studies. Finally, seven items were listed as future team activities.

  15. Responsive City Lighting

    DEFF Research Database (Denmark)

    Poulsen, Esben Skouboe; Andersen, Hans Jørgen; Jensen, Ole B.

    This paper presents and discusses perspectives extracted from two interviews conducted during the experiments Urban Responsive Lighting. The two experts embody two different fields related to city lighting: architecture & public lighting industry. The representatives were invited to the test......-site, where 15 LED RGB Park lamps, controlled driven by a wind sensor, mobile phone applications or by thermal camera tracking. According to the specialists are the social and aesthetical dimensions more interesting than the energy use cases and efficiency. This motivates an interdisciplinary discussion...

  16. Affect and criminal responsibility

    Directory of Open Access Journals (Sweden)

    Drakić Dragiša S.


    Full Text Available In this article the author deals with an issue of relationship between the affect and criminal responsibility. In order to provide a multi-angle approach to analysis of this issue the author resorted to multidisciplinary - criminal law and psychiatric-psychological approach. Although the topic covered by this article is significant and complex, it appears to be of virtually no interest in the literature. For that reason the author's endeavor to research this topic should not go unmentioned. In the first part of the article the author tried to provide answers to some preliminary questions without which it would be impossible to understand the relationship between the affect and criminal responsibility. Those are the following questions: what are affects, what is their nature and intensity, how long they last and how they influence psychological functions of a person acting in affect? Central part of the article is dedicated to examining the importance of the affect as a phenomenon in criminal law dogma and in judicial rulings, as well as its effect on criminal responsibility. The author finds that acting in affect may be considered as a mitigating circumstance in the sentencing, but can also be a basis for mitigation of the sentence or even suspension of the sentence, as part of some general criminal law norms. Also, for certain offenses it may be considered as a favorable condition that renders that offence to be less grave. Finally, the affect may be considered as a psychological basis diminished, or even lack of, mental capacity. The last above mentioned issue receives special attention of the author, and claims that only the affect that is 'of extreme proportions' may lead to mental incapacity. Such affect is the one that 'demolishes restrains and removes reasonable and target-oriented actions'. In further analysis the author proposes criteria and methodology for assessment of person's sanity in criminal law and criminal procedure. Further

  17. Scientific Social Responsibility?

    DEFF Research Database (Denmark)

    Glerup, Cecilie; Horst, Maja

    formed organizations to make science responsible for its social effects. More recently, ideals of increasing the social acceptability of science through engagement, reflexivity and dialogue seems to have found their way into the heart of policy-making, not least as a way of making science a prime motor...... the multiple experiments with different ways of "socializing science," defined both as making the social explicit and as changing the practices of science. In the study of the different approaches, we are particularly occupied with their normative foundation, their definition of the problem which justifies...

  18. Realizing Corporate Responsibility

    DEFF Research Database (Denmark)

    Girschik, Verena

    pharmaceutical company Novo Nordisk, a company known for its remarkable investments in integrating societal objectives into its business model and promoting new ways of thinking about and doing business. The case inspired the overarching theoretical question how actors construct and legitimize new ideas...... and practices at the nascent stages of institutional change. To address this question, the dissertation develops a micro-sociological approach to institutional change that brings to light how actors struggle over meaning in power relations by focusing on processes of positioning and framing. The three articles...... in this dissertation unfold distinct yet interdependent processes of positioning and framing that constitute new ways of performing and understanding corporate responsibility....

  19. Emotional response to advertising

    Directory of Open Access Journals (Sweden)

    Bogdan Anastasiei


    Full Text Available Emotions can transcend cultural, linguistic, demographic, and social boundaries. Emotions affect information processing and create a positive attitude toward the ad, which becomes associated with the brand. Objectives. This study investigates the role of pleasure (P, arousal (A and domination (D emotions in mobile’s photo camera advertisement and how each of them is influencing consumer attitude towards the advertisement and brand. Prior Work. Holbrook and Batra (1987 developed their own emotional scale based on these three dimensions (PAD, showing that these emotions mediate consumer responses to advertising. Approach. A 1*4 factorial experiment design method was adopted in order to measure the impact of independent variables (emotion type on dependent variables (attitude toward ad, attitude toward brand. Results. The results revealed that emotions like Pleasure (loving, friendly, grateful and Arousal (active, interested, excited, entertained influence consumers' attitudes towards brand and advertising. Value. Marketers need to understand the role of pleasure and arousal emotions when making advertising campaign; an effective promotion leads to persuading consumers. The results indicate that marketing practitioners should measure affective responses when testing an advertisement, as long as this action would predict brand attitude.

  20. State responses to biotechnology. (United States)

    Harris, Rebecca C


    This article reviews biotechnology legislation in the 50 states for 11 policy areas spanning 1990-2010, an era of immense growth in biotechnology, genetic knowledge, and significant policy development. Policies regarding health insurance, life insurance, long-term care insurance, DNA data bank collection, biotech research protection, biotech promotion and support, employment discrimination, genetic counselor licensing, human cloning, and genetic privacy each represent major policy responses arising from biotechnology and coinciding with key areas of state regulation (insurance, criminal justice, economic development, labor law, health and safety, privacy, and property rights). This analysis seeks to answer three questions regarding biotechnology legislation at the state level: who is acting (policy adoption), when is policy adopted (policy timing), and what is policy doing (policy content). Theoretical concerns examine state ideology (conservative or liberal), policy type (economic or moral), and the role of external events (federal law, news events, etc.) on state policy adoption. Findings suggest ideological patterns in adoption, timing, and content of biotech policy. Findings also suggest economic policies tend to be more uniform in content than moral policies, and findings also document a clear link between federal policy development, external events, and state policy response.

  1. Multilevel corporate environmental responsibility. (United States)

    Karassin, Orr; Bar-Haim, Aviad


    The multilevel empirical study of the antecedents of corporate social responsibility (CSR) has been identified as "the first knowledge gap" in CSR research. Based on an extensive literature review, the present study outlines a conceptual multilevel model of CSR, then designs and empirically validates an operational multilevel model of the principal driving factors affecting corporate environmental responsibility (CER), as a measure of CSR. Both conceptual and operational models incorporate three levels of analysis: institutional, organizational, and individual. The multilevel nature of the design allows for the assessment of the relative importance of the levels and of their components in the achievement of CER. Unweighted least squares (ULS) regression analysis reveals that the institutional-level variables have medium relationships with CER, some variables having a negative effect. The organizational level is revealed as having strong and positive significant relationships with CER, with organizational culture and managers' attitudes and behaviors as significant driving forces. The study demonstrates the importance of multilevel analysis in improving the understanding of CSR drivers, relative to single level models, even if the significance of specific drivers and levels may vary by context. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Playful Hyper Responsibility: Toward a Dislocation of Parents' Responsibility? (United States)

    Knudsen, Hanne; Andersen, Niels Åkerstrøm


    Over the past 10-15?years, state-funded schools have begun to require parents to assume an undefined and infinite personal responsibility. In this article, we investigate how schools organize responsibility games to respond to this challenge and how these games affect the concept of responsibility. We point to a dislocation in the way parents are…

  3. BAER - brainstem auditory evoked response (United States)

    ... auditory potentials; Brainstem auditory evoked potentials; Evoked response audiometry; Auditory brainstem response; ABR; BAEP ... Normal results vary. Results will depend on the person and the instruments used to perform the test.

  4. Gut Bacteria Affect Immunotherapy Response (United States)

    Three new studies have identified intestinal bacteria that appear to influence the response to checkpoint inhibitors. This Cancer Currents blog post explains how the researchers think their findings could be used to improve patients’ responses to these immunotherapy drugs.

  5. Personal Responsibility and Lifestyle Diseases

    DEFF Research Database (Denmark)

    Andersen, Martin Marchman; Nielsen, Morten Ebbe Juul


    , to be responsible for behaviors leading to increased risk of disease. We show that only what we call the causal approach can adequately accommodate widely shared intuitions to the effect that certain causal influences—such as genetic make-up or certain social circumstances—diminish, or undermine personal......What does it take for an individual to be personally responsible for behaviors that lead to increased risk of disease? We examine three approaches to responsibility that cover the most important aspects of the discussion of responsibility and spell out what it takes, according to each of them...... responsibility. However, accepting the causal approach most likely makes personal responsibility impossible. We therefore need either to reject these widely shared intuitions about what counts as responsibility-softening or undermining or to accept that personal responsibility for behaviors leading to increased...

  6. Multimodal responsive action

    DEFF Research Database (Denmark)

    Oshima, Sae

    While a first pair part projects a limited set of second pair parts to be provided next, responders select different types and formats for second pair parts to assemble activities (Schegloff 2007). Accordingly, various ways of shaping responses have been extensively studied (e.g. Pomerantz 1984...... the recipient’s gaze shift becomes a significant part of the speaker’s turn construction (Goodwin 1980), and when head nods show the recipient’s affiliation with the speaker’s stance (Stivers 2008). Still, much room remains for extending our current understanding of responding actions that necessarily involve...... both verbal and body-behavioral elements. This paper explores one such situation in professional-client interaction, during the event of evaluating a service outcome in a haircutting session. In general, a haircutting session is brought to its closure through the service-assessment sequence, in which...

  7. El consumo responsable


    Quirós Álvarez, Guillermo


    La necesidad de organizar la economía según la justicia, el respeto al ser humano y a los recursos naturales, ya no es una cuestión de opinión moral o política, es un imperativo que nos exige poner de nuestra parte. Esta posibilidad no deriva de derechos garantizados por la ley, sino de la voluntad de vivir de forma responsable en lo cotidiano. El consumidor es el último eslabón del sistema económico y como tal tiene la responsabilidad y el poder de cambiar el estado a que se nos induce por l...

  8. Scoping Memo Response

    Energy Technology Data Exchange (ETDEWEB)

    Goldstein, Noah [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Stewart, Jeff [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Lamont, Alan [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dube, Evi [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gansemer, Jim [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)


    What follows is a response to the questions posed in the May 21, 2010 document "Assigned Commissioner's Ruling and Scoping Memo, Phase 1", pertaining to Rulemaking 09-11-014, also referred to as the "Scoping Memo". The questions refer to the specific components of the CPUC Energy Efficiency (EE) Evaluation, Measurement, and Verification (EM&V) program, currently in its 2010-2012 cycle. In the Scoping Memo, there was reference to the need to update the policy and methodological framework of EM&V, due to changes in law (AB32), policy (California Long Term Energy Efficiency Strategic Plan), the availability of new data, and challenges to previous EM&V cycles.

  9. Responses from the Frontline

    DEFF Research Database (Denmark)

    Caswell, Dorte; Høybye-Mortensen, Matilde


    Economic sanctions have gained more political legitimacy and are being more widely used as a tool to improve the willingness of unemployed welfare recipients to participate in activities within the framework of active labour market policy (ALMP). The focus of this article is the use of economic...... sanctions on cash benefit recipients in Denmark. Quantitative analyses show a substantial increase in the use of economic sanctions in Denmark, including sanctions on those who are categorised as having problems in addition to unemployment. In this article we will direct our attention to responses from both...... differences in the use of sanctions from one municipality to another.Research on street-level bureaucracy focuses on the role of organisations when analysing street-level behaviour (Brodkin 2011; Soss et al. 2011b). This paper draws on this research, looking at organisational structure and how social workers...

  10. Organizations` responsibility to consumers

    Directory of Open Access Journals (Sweden)

    Vasile Dinu


    Full Text Available Relationships between organizations and consumers have a contradictory nature, because they are built on a base of imbalance between them, but can become, in a functioning market economy, partnerships, through which to resolve their interests, opposed as tendency, including conflict situations so that everyone ultimately gets what he wants, in the given historical conditions: organizations, the maximum possible profits and consumers, a higher degree of satisfaction of their needs. Market economies have as an existential fundament the competition, but the aspirations of a nation are founded on cooperation, on partnership. An economic system that divides people into winners and losers shouldn’t be promoted. For this reason, organizations must be more sensitive to the needs of society, as they are expressed through the values of the social human being (consumer compared to the values of the economic human being (producer, hence the need to increase their responsibilities to the consumer.

  11. Hanford Emergency Response Plan

    Energy Technology Data Exchange (ETDEWEB)

    Wagoner, J.D.


    The Hanford Emergency Response Plan for the US Department of Energy (DOE), Richland Operations Office (RL), incorporates into one document an overview of the emergency management program for the Hanford Site. The program has been developed in accordance with DOE orders, and state and federal regulations to protect worker and public health and safety and the environment in the event of an emergency at or affecting the Hanford Site. This plan provides a description of how the Hanford Site will implement the provisions of DOE 5500 series and other applicable Orders in terms of overall policies and concept of operations. It should be used as the basis, along with DOE Orders, for the development of specific contractor and RL implementing procedures.

  12. The Chronic Responsibility

    DEFF Research Database (Denmark)

    Ravn, Iben M; Frederiksen, Kirsten; Beedholm, Kirsten


    This article reports on the results of a Fairclough-inspired critical discourse analysis aiming to clarify how chronically ill patients are presented in contemporary Danish chronic care policies. Drawing on Fairclough’s three-dimensional framework for analyzing discourse, and using Dean’s concepts...... of governmentality as an interpretative lens, we analyzed and explained six policies published by the Danish Health and Medicines Authority between 2005 and 2013. The analysis revealed that discourses within the policy vision of chronic care consider chronically ill patients’ active role, lifestyle, and health...... behavior to be the main factors influencing susceptibility to chronic diseases. We argue that this discursive construction naturalizes a division between people who can actively manage responsible self-care and those who cannot. Such discourses may serve the interests of those patients who are already...

  13. Responsive acoustic surfaces

    DEFF Research Database (Denmark)

    Peters, Brady; Tamke, Martin; Nielsen, Stig Anton


    Acoustic performance is defined by the parameter of reverberation time; however, this does not capture the acoustic experience in some types of open plan spaces. As many working and learning activities now take place in open plan spaces, it is important to be able to understand and design...... for the acoustic conditions of these spaces. This paper describes an experimental research project that studied the design processes necessary to design for sound. A responsive acoustic surface was designed, fabricated and tested. This acoustic surface was designed to create specific sonic effects. The design...... was simulated using custom integrated acoustic software and also using Odeon acoustic analysis software. The research demonstrates a method for designing space- and sound-defining surfaces, defines the concept of acoustic subspace, and suggests some new parameters for defining acoustic subspaces....

  14. Corporate Social Responsibility

    DEFF Research Database (Denmark)

    Kampf, Constance


    Understanding Corporate Social Responsibility (CSR) as having explicit policies and implicit norms situated in cultural systems highlights the connections between institutional and cultural structures of nation states and business' commitment to CSR as reflected in the strategies used...... to communicate CSR to public audiences via the Internet.  To frame CSR from a situated perspective (Matten & Moon 2005) implies a shift in understanding relations between corporations and their stakeholders from a corporate-centered model to a cultural systems perspective.  This paper describes an approach...... to cultural systems in which can be used to frame our understanding of implicit norms with respect to CSR, and demonstrates how these norms result in different practices of communicating CSR in the WalMart and Maersk corporate websites....

  15. Complex Deployed Responsive Service (United States)

    Parry, Glenn; McLening, Marc; Caldwell, Nigel; Thompson, Rob

    A pizza restaurant must provide product, in the form of the food and drink, and service in the way this is delivered to the customer. Providing this has distinct operational challenges, but what if the restaurant also provides a home delivery service? The service becomes deployed as the customer is no-longer co-located with the production area. The business challenge is complicated as service needs to be delivered within a geographic region, to time or the pizza will be cold, and within a cost that is not ­prohibitive. It must also be responsive to short term demand; needing to balance the number of staff it has available to undertake deliveries against a forecast of demand.

  16. Thermal Responsive Envelope

    DEFF Research Database (Denmark)

    Foged, Isak Worre; Pasold, Anke


    alterations, their respective durability and copper’s architectural (visual and transformative) aesthetic qualities. Through the use of an evolutionary solver, the composite structure of the elements are organised to find the bending behaviour specified by and for the thermal environments. The entire model......The paper presents an architectural computational method and model, which, through additive and subtractive processes, create composite elements with bending behaviour based on thermal variations in the surrounding climatic environment. The present effort is focused on the manipulation of assembly...... composite layers and their relative layer lengths thereby embedding the merged material effect to create a responsive behavioural architectural envelope. Copper and polypropylene are used as base materials for the composite structure due to their high differences in thermal expansion, surface emissivity...

  17. Signals and Responses (United States)

    Lee, Angie


    The nitrogen-fixing symbiosis between bacteria in the family Rhizobiaceae and members of the legume family (Fabaceae) has been well studied, particularly from the perspective of the early signaling and recognition events. Recent studies of non-nodulating legume mutants have resulted in the identification of a number of genes that are responsive to signal molecules from the bacteria. However, a second group of nodule-forming bacteria, completely unrelated to the Rhizobiaceae, which are α-Proteobacteria, has been discovered. These bacteria belong to the β-Proteobacteria and have been designated β-rhizobia to distinguish them from the better-known α-rhizobia. Here, we review what is known in this economically important symbiosis about the interaction between legumes and α-rhizobia, and we incorporate information, where known, about the β-rhizobia. PMID:19521481

  18. Socially Responsible Investing

    DEFF Research Database (Denmark)

    Parisi, Cristiana; Stang, Andreas

    This paper analyzes the Scandinavian market for Socially Responsible Investing (SRI) mutual funds in order to determine the returns from discriminatory investment decision compared to the return from conventional portfolios. The analysis is conducted on 642 Scandinavian equity mutual funds....... The methodology adopts the Sharpe ratio to establish the risk return relationship. Moreover, the Capital Asset Pricing Model (CAPM) and the Fama and French Three Factor model are used to test the hypotheses. The results indicate the underperformance of Swedish and Danish SRI funds relative to their conventional...... counterparts. In the case of Norway no statistical difference in return is found when conducting the three factor regression. The Scandinavian market is considered particularly relevant for the interest of the investors in SRI mutual funds. However, to the authors’ knowledge, this is the first study to present...

  19. Affective responses to dance. (United States)

    Christensen, Julia F; Pollick, Frank E; Lambrechts, Anna; Gomila, Antoni


    The objective of the present work was the characterization of mechanisms by which affective experiences are elicited in observers when watching dance movements. A total of 203 dance stimuli from a normed stimuli library were used in a series of independent experiments. The following measures were obtained: (i) subjective measures of 97 dance-naïve participants' affective responses (Likert scale ratings, interviews); and (ii) objective measures of the physical parameters of the stimuli (motion energy, luminance), and of the movements represented in the stimuli (roundedness, impressiveness). Results showed that (i) participants' ratings of felt and perceived affect differed, (ii) felt and perceived valence but not arousal ratings correlated with physical parameters of the stimuli (motion energy and luminance), (iii) roundedness in posture shape was related to the experience of more positive emotion than edgy shapes (1 of 3 assessed rounded shapes showed a clear effect on positiveness ratings while a second reached trend level significance), (iv) more impressive movements resulted in more positive affective responses, (v) dance triggered affective experiences through the imagery and autobiographical memories it elicited in some people, and (vi) the physical parameters of the video stimuli correlated only weakly and negatively with the aesthetics ratings of beauty, liking and interest. The novelty of the present approach was twofold; (i) the assessment of multiple affect-inducing mechanisms, and (ii) the use of one single normed stimulus set. The results from this approach lend support to both previous and present findings. Results are discussed with regards to current literature in the field of empirical aesthetics and affective neuroscience. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Can Arousal Modulate Response Inhibition? (United States)

    Weinbach, Noam; Kalanthroff, Eyal; Avnit, Amir; Henik, Avishai


    The goal of the present study was to examine if and how arousal can modulate response inhibition. Two competing hypotheses can be drawn from previous literature. One holds that alerting cues that elevate arousal should result in an impulsive response and therefore impair response inhibition. The other suggests that alerting enhances processing of…

  1. Social Facilitation of Aiding Responses. (United States)

    Bartell, Patricia; And Others

    Research on individual's response to emergency situations in the presence of others has produced conflicting results. The bystander effect is the label applied to inaction or the unlikelihood of assistance with others present. The social facilitation effect occurs when the presence of others energizes response; strong habit responses are…

  2. Dopa-responsive dystonia

    Directory of Open Access Journals (Sweden)

    Đurić Gordana


    Full Text Available Backgrround/Aim. Dystonia is considered to be a prolonged involuntary contractions of the muscles leading to twisting, repetitive movements or irregular postures. Etiologically, it could be classified as primary and secondary dystonia. Dopa-responsive dystonia (DRD belongs to a group of primary dystonia. The aim of this study was to detect the presence of gene GCH-I mutation in our population in patients with dopa-responsive dystonic dyskinesia and to analyze clinical specificity of the affected. Methods. Out of the group of patients with dystonia of different distribution four patients were separated whose clinical picture indicated the diagnosis of DRD. Two patients had a positive family anamnesis while the other two were sporadic. Genetic analysis was performed by the use of a standard protocol, which included PCR amplification and DNK sequencing according to the method of Senger and autoradiografy. Results. In the patients from the family DRD-1 new hetaerazygote point mutation 520G→A in 4-m exson gene GCH-I was revealed. First symptoms of the disease showed in the age of seven by the torsion of the left foot, progressively advanced and got into the evolution of numbness in the legs, aggravated gait, tending to worsen in the evening, and the therapy with levodopa (500 mg produced a dramatic effect. The second mutation in the female patient from the family DRD-2 was homozygote deletion in1-m intron gene GCH-I (IVS1-85delA. Unwilling torsion of the foot, feeling of weakness in the lower extremities (that caused falling without loss of the consciousness were clinical demonstrations of the disease. The application of levodopa (300 mg caused regression of the symptoms of the disease. Hetaerazygote deletion of adenine in the position 209 in the first exon (209del A was identificated in the patient DRD-3 with negative family anamnesis, in who in the age of ten the torsion of the foot inside occurred for the first time following by trembling of

  3. Corporate social responsibility in hospitality

    Directory of Open Access Journals (Sweden)

    Snježana Gagić


    Full Text Available Responsible management of global hospitality companies increasingly recognizes how important are concerns about the society, the environment as well as all stakeholders in maintaining a good market position. In Serbia, the concept of corporate social responsibility is relatively unknown and insufficiently researched in all business areas, especially in the hospitality industry where small businesses are dominated. The papers task is to present particular activities that demonstrate social responsibility to employees, customers-guests, local communities as well as the environment. The paper aims to highlight the benefits of adopting the principles of corporate social responsibility and innovation applied in catering enterprises as an example of good corporate social responsibility practices.

  4. Assessing Imaging Response to Therapy. (United States)

    Minocha, Jeet; Lewandowski, Robert J


    Locoregional therapies (LRTs) have proved valuable in the treatment of patients with cancer, most commonly in the liver. Accurate assessment of response to these therapies is crucial because objective response can be a surrogate of improved survival. Imaging plays an essential role in the objective evaluation of tumor response to most cancer therapies, including LRTs. Assessing imaging response to LRTs, however, can be challenging and is evolving. This article reviews the different criteria used to assess radiologic response to LRTs, with special attention to imaging assessment following treatment of hepatocellular carcinoma. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Remune. Immune Response. (United States)

    Lai, Derhsing; Jones, Taff


    The Immune Response Corp (IRC) is developing Remune, a potential HIV therapeutic vaccine. Remune is based on the Salk Immunogen, which is derived from an HIV isolate which has been inactivated by chemical depletion of glycoprotein 120 (gp120). Preliminary data suggested that Remune, in combination with antiviral drug therapy, results in undetectable levels of HIV. Phase III trials commenced in May 1997 and it was initially expected that registration filings would be made in 1999. However, following interim analysis of the 2500-patient, multicenter, double-blind, pivotal phase III study (study 806) in May 1999, an independent panel recommended concluding the clinical endpoint trial and IRC and licensee, Agouron, decided to pursue alternative regulatory strategies, including initiating two additional phase III surrogate marker trials. Despite this, Agouron gave IRC notice of termination of its continued development in July 2001. In August 2001, IRC informed Agouron that, due to the total number of endpoints to date falling short of that previously assumed by Agouron, it did not intend to continue Agouron's Study 202 of Remune. In July 2001, licensee Trinity Medical Group filed an NDA with the governing health authorities in Thailand for Remune. The Thai FDA certified Immune Response's Remune manufacturing facility as being in compliance with GMP standards, following an on site inspection by Thai officials in November 2001 that was performed as a requirement of Trinity's Thai NDA. As a result of this certification, Trinity expected that a "timely determination" could be made by the Thai FDA. Rhĵne-Poulenc Rorer discontinued its part in the development of Remune, with all manufacturing, marketing and distribution rights reverting to IRC. After Agouron returned rights to Remune in July 2001, IRC heldfull rights in the US, Europe and Japan, while collaborating with its partners Trinity Medical Group and Roemmers Laboratory in the Southeast Asian and Latin American

  6. Age affects drivers' response times. (United States)

    Bilban, Marjan; Vojvoda, Alenka; Jerman, Janez


    In Slovenia the number of drivers over 65 is increasing every year. With age comes a decrease in psychophysical abilities, which include sensory and motoric functions and the ability of processing visual information. These changes increase the response time and decrease the driving capacity. The aim of this study was to establish a correlation between age and response time and to determine the difference in response times between men and women. In the research participated 573 randomly chosen drivers aged 19-80 with a valid driving license. We measured their response times, when stimulated by a red traffic light, on a simulator The results clearly demonstrate that a correlation between age and the response time exists. The results show that a significant increase in response times occurs after the age of 65. In all age groups, except the oldest, women achieved longer response times than men.

  7. Why Pandemic Response is Unique

    DEFF Research Database (Denmark)

    Bækkeskov, Erik; Rubin, Olivier


    , the case studies of media coverage in the USA and Denmark demonstrate that the response was bureaucratized in the public health agencies (CDC and DMHA, respectively). Hence, while natural disaster responses appear to follow a political logic, the response to pandemics appears to be more strongly instituted...... attention and coverage in two deviant cases, the USA and Denmark. Findings – Theories linking political survival to disaster responses find little empirical support in the substantial cross-country variations of vaccination responses during the 2009 H1N1 pandemic. Rather than following a political logic...... in the hands of bureaucratic experts. Research limitations/implications – There is an added value of encompassing bureaucratic dynamics in political theories of disaster response; bureaucratized expertise proved to constitute a strong plausible explanation of the 2009 pandemic vaccination response. Practical...

  8. Emergency Response Guideline Development

    Energy Technology Data Exchange (ETDEWEB)

    Gary D. Storrick


    Task 5 of the collaborative effort between ORNL, Brazil, and Westinghouse for the International Nuclear Energy Research Initiative entitled “Development of Advanced Instrumentation and Control for an Integrated Primary System Reactor” focuses on operator control and protection system interaction, with particular emphasis on developing emergency response guidelines (ERGs). As in the earlier tasks, we will use the IRIS plant as a specific example of an integrated primary system reactor (IPSR) design. The present state of the IRIS plant design – specifically, the lack of a detailed secondary system design – precludes establishing detailed emergency procedures at this time. However, we can create a structure for their eventual development. This report summarizes our progress to date. Section 1.2 describes the scope of this effort. Section 2 compares IPSR ERG development to the recent AP1000 effort, and identifies three key plant differences that affect the ERGs and control room designs. The next three sections investigate these differences in more detail. Section 3 reviews the IRIS Safety-by-Design™ philosophy and its impact on the ERGs. Section 4 looks at differences between the IRIS and traditional loop PWR I&C Systems, and considers their implications for both control room design and ERG development. Section 5 examines the implications of having one operating staff control multiple reactor units. Section 6 provides sample IRIS emergency operating procedures (EOPs). Section 7 summarizes our conclusions.

  9. Social Economy and Responsibility

    Directory of Open Access Journals (Sweden)

    Eva Abramuszkinová Pavlíková


    Full Text Available Given the importance of entrepreneurial activities as an engine of economic growth and poverty alleviation, the issue of business development and entrepreneurial activities, has received increasing attention from a number of interested parties worldwide and also in the Czech Republic. The focus of this paper is on a social economy, a social responsibility and social enterprises. The development of the social economy framework will be introduced in the European context and specifically in the Czech Republic. A case study of a Czech social entrepreneur will be introduced based on qualitative research, namely the biographical narrative method.Social enterprises can support activities of various target groups, such as economic activities of mentally and physically handicapped people, which often operate in economically and socially marginalized situations, including stereotyped images. They give them a chance to become active members of society. In this way they can help to reduce the poverty on a local level. The aim of this paper is to introduce a social entrepreneurship as important part of social economy development in the Czech Republic.

  10. Joined and Responsible Parenting

    Directory of Open Access Journals (Sweden)

    Selmani-Bakiu Arta


    Full Text Available In the contemporary family law, parents are obliged to arrange the joined implementation of the parenting rights either by their own will or through the help of their lawyers and/or mediators. This institute of mutual agreement is known as joined custody or joined implementation of the parenting right after the divorce of the marriage. This institute makes it possible for parents who live separately to arrange their custody rights in the most convenient way for the child. With a joined custody agreement, the parents accept the obligation to implement all the rights and duties that constitute the parenting right even in case of their separation. Through not dividing their rights from their obligations and with the aim of being closer to the needs of the child, the institute of joined custody helps avoid the feelings of hostility and disagreement in regard to the judicial decision which gives permanent custody to one of the parents. This institute is incorporated in the family law of many countries (Sweden, Norway, Finland, Denmark, UK, France, Italy, Germany, Belgium, Switzerland, Hungary, Czech Republic, USA and Australia. This article aims to emphasize the need to introduce in the family law of RM an explicit provision for joined and responsible custody after the divorce in order to achieve the best interest of the child. There is a joined initiative of parents who live separately from their children who request the amendment of the Family Law of RM in this direction.

  11. Rapid response manufacturing (RRM)

    Energy Technology Data Exchange (ETDEWEB)

    Cain, W.D. [Lockheed Martin Energy Systems, Inc., Oak Ridge, TN (United States); Waddell, W.L. [National Centers for Manufacturing Sciences, Ann Arbor, MI (United States)


    US industry is fighting to maintain its competitive edge in the global market place. Today markets fluctuate rapidly. Companies, to survive, have to be able to respond with quick-to-market, improved, high quality, cost efficient products. The way products are developed and brought to market can be improved and made more efficient through the proper incorporation of emerging technologies. The RRM project was established to leverage the expertise and resources of US private industries and federal agencies to develop, integrate, and deploy new technologies that meet critical needs for effective product realization. The RRM program addressed a needed change in the US Manufacturing infrastructure that will ensure US competitiveness in world market typified by mass customization. This project provided the effort needed to define, develop and establish a customizable infrastructure for rapid response product development design and manufacturing. A major project achievement was the development of a broad-based framework for automating and integrating the product and process design and manufacturing activities involved with machined parts. This was accomplished by coordinating and extending the application of feature-based product modeling, knowledge-based systems, integrated data management, and direct manufacturing technologies in a cooperative integrated computing environment. Key technological advancements include a product model that integrates product and process data in a consistent, minimally redundant manner, an advanced computer-aided engineering environment, knowledge-based software aids for design and process planning, and new production technologies to make products directly from design application software.

  12. Vaccines, our shared responsibility. (United States)

    Pagliusi, Sonia; Jain, Rishabh; Suri, Rajinder Kumar


    The Developing Countries Vaccine Manufacturers' Network (DCVMN) held its fifteenth annual meeting from October 27-29, 2014, New Delhi, India. The DCVMN, together with the co-organizing institution Panacea Biotec, welcomed over 240 delegates representing high-profile governmental and nongovernmental global health organizations from 36 countries. Over the three-day meeting, attendees exchanged information about their efforts to achieve their shared goal of preventing death and disability from known and emerging infectious diseases. Special praise was extended to all stakeholders involved in the success of polio eradication in South East Asia and highlighted challenges in vaccine supply for measles-rubella immunization over the coming decades. Innovative vaccines and vaccine delivery technologies indicated creative solutions for achieving global immunization goals. Discussions were focused on three major themes including regulatory challenges for developing countries that may be overcome with better communication; global collaborations and partnerships for leveraging investments and enable uninterrupted supply of affordable and suitable vaccines; and leading innovation in vaccines difficult to develop, such as dengue, Chikungunya, typhoid-conjugated and EV71, and needle-free technologies that may speed up vaccine delivery. Moving further into the Decade of Vaccines, participants renewed their commitment to shared responsibility toward a world free of vaccine-preventable diseases. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  13. Initiatives of Ecological Responsibility

    Directory of Open Access Journals (Sweden)

    Roman Sergeevich Volodin


    Full Text Available Preservation of environment is one of the global problems for the mankind. The concept of sustainable development presented at the governmental level in 1987 urged to fix at the interstate level the basic principles of development of humanity in harmony with the nature. The Charter signed in 1991 “Business and sustainable development” proclaimed a new stage of development of world entrepreneurship – business had to become ecologicallyoriented and to form the ecologically-oriented demand. In recent years it is possible to state the huge growth of technologies of effective environmental management, energy saving and energy efficiency. The leading world corporations include reduction of the ecological aspects in priority strategic objectives, as much as possible promoting transition to the use of green technologies. “Green” experience of the Western companies showed that reduction of influence on environment is not only the task of the state, but also the effective instrument to increase competitiveness of the organization. Besides the growth of favorable perception of the company by consumers, it receives considerable decrease in prime cost of the made production or the rendered services due to effective and economical use of natural resources. Russia is among the first countries who accepted the concept of sustainable development at the legislative level, nevertheless, only recently we can note that technologies of rational environmental management, energy saving and energy efficiency became one of priority problems of its development. In the present article the advanced methods of the state and private initiatives in the field of ecological responsibility are considered, and the methods of overcoming the new challenges are offered.

  14. Building a rapid response team. (United States)

    Halvorsen, Lisa; Garolis, Salomeja; Wallace-Scroggs, Allyson; Stenstrom, Judy; Maunder, Richard


    The use of rapid response teams is a relatively new approach for decreasing or eliminating codes in acute care hospitals. Based on the principles of a code team for cardiac and/or respiratory arrest in non-critical care units, the rapid response teams have specially trained nursing, respiratory, and medical personnel to respond to calls from general care units to assess and manage decompensating or rapidly changing patients before their conditions escalate to a full code situation. This article describes the processes used to develop a rapid response team, clinical indicators for triggering a rapid response team call, topics addressed in an educational program for the rapid response team members, and methods for evaluating effectiveness of the rapid response team.

  15. Network Culture, Performance & Corporate Responsibility


    Brondoni, Silvio M


    The growth and sustainability of free market economies highlights the need to define rules more suited to the current condition of market globalisation and also encourages firms to adopt more transparent and accountable corporate responsibility (and corporate social responsibility, namely the relationship between the company, environment and social setting). From a managerial perspective, corporate responsibility is linked to ensure the lasting pursuit of the company mission, seeking increasi...

  16. Corporate Social Responsibility in Ukraine


    Stepanenko, Ievgeniia


    In the article are considered essence of corporate social responsibility and terms necessary for realization of social activity management subjects. Hikes over are brought to realization of corporate social responsibility, meaningfulness of large and middle business is certain in becoming of social responsibility of enterprises. It is set that exactly midsize business must come forward as a main motor of economic development of Ukraine. Becoming features and modern state of corporate social r...

  17. Coordinating Military Response to Disasters (United States)


    encompasses the Caribbean Islands outside of the U.S. territories. I will examine SOUTHCOM’s response to the earthquake in Haiti 2010 to show the lack effective and timely response to the island. In a report conducted by the RAND corporation, it revealed the earthquake that struck Haiti in...Wermuth, Timothy Jackson, Agnes Gereben Schaefer and Matthew Stafford. The U.S. Military Response to the 2010 Haiti Earthquake : Considerations for

  18. Property Rights, Restrictions and Responsibilities

    DEFF Research Database (Denmark)

    Enemark, Stig

    Land Administration Systems are the basis for conceptualizing rights, restrictions and responsibilities related to people, policies and places. Property rights are normally concerned with ownership and tenure whereas restrictions usually control use and activities on land. Responsibilities relate...... more to a social, ethical commitment or attitude to environmental sustainability and good husbandry. This paper provides an overall understanding of the concept of land administration systems for dealing with rights, restrictions and responsibilities in future spatially enabled government. Finally...

  19. Responsible nanotechnology development (United States)

    Forloni, Gianluigi


    the nanotoxicology. The establishment of an effective strategy cannot ignore the distinction between different nanoparticles on their use and the type of exposure to which we are subjected. Categorization is essential to orchestrate toxicological rules realistic and effective. The responsible development of nanotechnology means a common effort, by scientists, producers, stakeholders, and public institutions to develop appropriate programs to systematically approach the complex issue of the nanotoxicology.

  20. A Mixed Effects Randomized Item Response Model (United States)

    Fox, J.-P.; Wyrick, Cheryl


    The randomized response technique ensures that individual item responses, denoted as true item responses, are randomized before observing them and so-called randomized item responses are observed. A relationship is specified between randomized item response data and true item response data. True item response data are modeled with a (non)linear…


    Directory of Open Access Journals (Sweden)



    Full Text Available The role of corporate social responsibility has increased significantly nowadays. The studies conducted have shown that consumers are increasingly no longer interested only in buying good quality and reliable products, but they are also interested whether they were produced in a socially responsible manner. In the recent years investors have increasingly realised that investing in social responsibility regarding the social and environmental areas, greatly contributes to the growth of the internal and external image of management. This paper aims at presenting a number of interesting issues related to social responsibility manifested by the insurance companies.

  2. Rights and responsibilities in Darfur

    Directory of Open Access Journals (Sweden)

    Katherine Reyes


    Full Text Available A combined UN-military-police-humanitarian initiative hasbeen promoting civic rights and responsibilities among IDPsin order to increase security throughout Kalma camp and itssurroundings.

  3. Leadership Development: A Supervisory Responsibility

    National Research Council Canada - National Science Library

    French, David


    .... This is a recurring theme found throughout leadership literature and speeches. The US Air Force clearly establishes subordinate development as a supervisory responsibility in top-level doctrine...


    Directory of Open Access Journals (Sweden)

    MI Mitha Dwi Restuti


    Full Text Available Tujuan penelitian ini adalah untuk mengetahui pengaruh negatif pengungkapan Corporate Sosial Responsibility (CSR disclosure terhadap Earning Response Coefficient (ERC. Alat analisis yang digunakan dalam penelitian ini menggunakan metode analisis regresi berganda.Sampel yang digunakan adalah sebanyak 150 perusahaan yang terdaftar pada Bursa Efek Indonesia pada tahun 2010. Berdasarkan hasil penelitian ditemukan bahwa pengungkapan Corporate Social Responsibility tidak berpengaruh terhadap Earning Response Coefficient (ERC. Hal ini dapat dikatakan bahwa investor belum memperhatikan informasi-informasi sosial yang diungkapkan dalam laporan tahunan perusahaan sebagai informasi yang dapat mempengaruhi investor dalam melakukan keputusan investasi. Investor masih mengganggap informasi laba lebih bermanfaat dalam menilai perusahaan dan dianggap lebih mampu memberikan informasi untuk mendapatkan return saham yang diharapkan oleh investor dibandingkan dengan informasi sosial yang diungkapkan oleh perusahaan.The purpose of this study is to determine the negative effect of Corporate Social Responsibility disclosure (CSR disclosure of Earnings Response Coefficient (ERC. Multiple regressions were used to analyze the data. The samples were 150 companies listed on the Indonesia Stock Exchange in 2010. Based on the research, the result was the disclosures of Corporate Social Responsibility did not influence Earning Response Coefficient (ECR. It can be said that investors did not pay attention to social information that was disclosed in the company’s annual report as information that could affect investors in making investment decisions. Investor did not consider sosial information; they only consider profit information to assess the company value and their investment return

  5. Response Strategies and Response Styles in Cross-Cultural Surveys

    NARCIS (Netherlands)

    Morren, M.H.; Gelissen, J.P.T.M.; Vermunt, J.K.


    This article addresses the following research questions: Do respondents participating in cross-cultural surveys differ in their response style when responding to attitude statements? If so, are characteristics of the response process associated with their ethnicity and generation of immigration? To

  6. Panel design effects on response rates and response quality

    NARCIS (Netherlands)

    R. Seger; Ph.H.B.F. Franses (Philip Hans)


    textabstractTo understand changes in individuals' opinions and attitudes it would be best to collect data through panels. Such panels, however, often cause irritation among respondents, resulting in low response rates and low response quality. We address whether this problem can be alleviated by

  7. Motivation of chemical industry social responsibility through Responsible Care. (United States)

    Givel, Michael


    Advocates of corporate social responsibility argue corporations should not only meet the needs of shareholders, but other key stakeholders including the community, customers, suppliers, and employees. Since 1988, the chemical industry has engaged in a major self-regulatory "Responsible Care" industry-wide social responsibility campaign to ensure environmental, public health, safety, and security performance among member companies. Contrary to the arguments of advocates of corporate social responsibility that such efforts meet the needs of stakeholders other than shareholders such as the community, the primary goal of the Responsible Care effort has been to change public concerns and opinion about chemical industry environmental and public health practices while also opposing support for stronger and more expensive public health and environmental legislation and regulation of chemical products, even if warranted.

  8. Response moderation models for conditional dependence between response time and response accuracy. (United States)

    Bolsinova, Maria; Tijmstra, Jesper; Molenaar, Dylan


    It is becoming more feasible and common to register response times in the application of psychometric tests. Researchers thus have the opportunity to jointly model response accuracy and response time, which provides users with more relevant information. The most common choice is to use the hierarchical model (van der Linden, 2007, Psychometrika, 72, 287), which assumes conditional independence between response time and accuracy, given a person's speed and ability. However, this assumption may be violated in practice if, for example, persons vary their speed or differ in their response strategies, leading to conditional dependence between response time and accuracy and confounding measurement. We propose six nested hierarchical models for response time and accuracy that allow for conditional dependence, and discuss their relationship to existing models. Unlike existing approaches, the proposed hierarchical models allow for various forms of conditional dependence in the model and allow the effect of continuous residual response time on response accuracy to be item-specific, person-specific, or both. Estimation procedures for the models are proposed, as well as two information criteria that can be used for model selection. Parameter recovery and usefulness of the information criteria are investigated using simulation, indicating that the procedure works well and is likely to select the appropriate model. Two empirical applications are discussed to illustrate the different types of conditional dependence that may occur in practice and how these can be captured using the proposed hierarchical models. © 2016 The British Psychological Society.

  9. Psychophysiological responses to Salsa dance. (United States)

    Guidetti, Laura; Buzzachera, Cosme Franklim; Emerenziani, Gian Pietro; Meucci, Marco; Saavedra, Francisco; Gallotta, Maria Chiara; Baldari, Carlo


    Speculation exists whether dance provides physiological stimuli adequate to promote health and fitness benefits. Unfortunately, research to date has not addressed the affective and exertional responses to dance. These responses are of interest as positive affective and exertional responses experienced during physical activity may play an important role in predicting adherence. The present study aims to examine the psychophysiological responses of different Salsa dance styles. Ten pairs of dancers performed two different structured lessons of Salsa dance, including Typical Salsa and Rueda de Casino lessons, and a non-structured Salsa dance at a night club. Physiological responses (i.e., percent of heart rate reserve; %HRR) were continuously assessed and perceived exertion and affective valence were rated every 15 min throughout the trials. %HRR responses differed between the Salsa dance styles (%HRR from 41.3 to 51.9%), and participants were dancing at intensities near their ventilatory threshold. Specifically, Typical Salsa lesson elicited lower %HRR responses than Rueda de Casino lesson (p dance at a night club condition (p > 0.05). Surprisingly, exertional (from 8 to 11) and affective (from +3 to +5) responses were unaffected by Salsa dance styles (p > 0.05). These data support that different Salsa dance styles provide physiological stimuli adequate to promote health and fitness benefits, and perhaps more importantly, produce pleasurable experiences, which in turn might lead to an increase in adherence to Salsa dancing which likely provides exercise-like health benefits.

  10. Psychophysiological responses to Salsa dance.

    Directory of Open Access Journals (Sweden)

    Laura Guidetti

    Full Text Available Speculation exists whether dance provides physiological stimuli adequate to promote health and fitness benefits. Unfortunately, research to date has not addressed the affective and exertional responses to dance. These responses are of interest as positive affective and exertional responses experienced during physical activity may play an important role in predicting adherence. The present study aims to examine the psychophysiological responses of different Salsa dance styles. Ten pairs of dancers performed two different structured lessons of Salsa dance, including Typical Salsa and Rueda de Casino lessons, and a non-structured Salsa dance at a night club. Physiological responses (i.e., percent of heart rate reserve; %HRR were continuously assessed and perceived exertion and affective valence were rated every 15 min throughout the trials. %HRR responses differed between the Salsa dance styles (%HRR from 41.3 to 51.9%, and participants were dancing at intensities near their ventilatory threshold. Specifically, Typical Salsa lesson elicited lower %HRR responses than Rueda de Casino lesson (p 0.05. Surprisingly, exertional (from 8 to 11 and affective (from +3 to +5 responses were unaffected by Salsa dance styles (p > 0.05. These data support that different Salsa dance styles provide physiological stimuli adequate to promote health and fitness benefits, and perhaps more importantly, produce pleasurable experiences, which in turn might lead to an increase in adherence to Salsa dancing which likely provides exercise-like health benefits.

  11. An Anatomy of Moral Responsibility

    NARCIS (Netherlands)

    Braham, M.; van Hees, M.V.B.P.M

    This paper examines the structure of moral responsibility for outcomes. A central feature of the analysis is a condition that we term the 'avoidance potential', which gives precision to the idea that moral responsibility implies a reasonable demand that an agent should have acted otherwise. We show

  12. Thermal Response Of Composite Insulation (United States)

    Stewart, David A.; Leiser, Daniel B.; Smith, Marnell; Kolodziej, Paul


    Engineering model gives useful predictions. Pair of reports presents theoretical and experimental analyses of thermal responses of multiple-component, lightweight, porous, ceramic insulators. Particular materials examined destined for use in Space Shuttle thermal protection system, test methods and heat-transfer theory useful to chemical, metallurgical, and ceramic engineers needing to calculate transient thermal responses of refractory composites.

  13. Data modelling for emergency response

    NARCIS (Netherlands)

    Dilo, Arta; Zlatanova, Sidi


    Emergency response is one of the most demanding phases in disaster management.The fire brigade, paramedics, police and municipality are the organisations involved in the first response to the incident. They coordinate their work based on welldefined policies and procedures, but they also need the

  14. Hemicrania continua responsive to verapamil. (United States)

    Rajabally, Yusuf A; Jacob, Saiju


    Hemicrania continua (HC) is a rare headache syndrome, typically responsive to indomethacin, although patients resistant to this drug have been described. Few treatment alternatives have been proposed in the literature. We here report a patient with HC whose initial excellent response to indomethacin faded but then responded remarkably to verapamil.

  15. Randomized Item Response Theory Models

    NARCIS (Netherlands)

    Fox, Gerardus J.A.


    The randomized response (RR) technique is often used to obtain answers on sensitive questions. A new method is developed to measure latent variables using the RR technique because direct questioning leads to biased results. Within the RR technique is the probability of the true response modeled by

  16. Corporate Responses to Stakeholder Activism

    DEFF Research Database (Denmark)

    Uldam, Julie; Krause Hansen, Hans


    of the Extractive Industries Transparency Initiative (EITI), Shell and BP, drawing on qualitative methods. Findings: The paper demonstrates that overt responses create an impression of consensus between antagonistic interests and that covert responses support this impression by containing deep-seated conflicts...

  17. Individual Rights versus Institutional Responsibilities. (United States)

    Stager, Susan


    Discusses individual rights versus institutional responsibilities as addressed in the Bill of Rights and Responsibilities for Electronic Learners. Topics addressed include freedom of speech and First Amendment rights; freedom of the press; freedom of assembly; right to privacy; freedom from unreasonable searches; due process; and future issues.…

  18. Rangeland -- Plant responses to elevated CO{sub 2}. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Owensby, C.E.; Coyne, P.I.; Ham, J.M.; Parton, W.; Rice, C.; Auen, L.M.; Adam, N.


    Several broad conclusions which can be drawn from the work that was accomplished during the first 3-year phase of the study is described. In prairie ecosystems dominated by C{sub 4} grasses, it is likely that elevated atmospheric CO{sub 2} will increase ecosystem level productivity, with a greater increase in belowground productivity. The increased productivity will primarily result from increased water use efficiency due to the anti-transpirant action of CO{sub 2}. Fumigation chambers are directly confounded with elevated CO{sub 2} effects, in that both reduce evapotranspiration. The reduced evapotranspiration of the fumigation chamber is primarily through reduced wind speeds and reduced radiation. In very dry years, fumigation chamber effects are negligible, but in years with normal precipitation, chamber effects and elevated CO{sub 2} effects are essentially equal with respect to reduced evapotranspiration effects. Increased production under elevated CO{sub 2} results in reduced nitrogen concentration in the herbage and increased fiber concentrations. Consequently, digestibility of the herbage is reduced, and microbial degradation of surface litter and soil organic matter is slowed. On the negative side, ruminant productivity will likely be reduced substantially, but increased carbon storage in the soil may buffer against future rise in atmospheric CO{sub 2}. Tallgrass prairie will not likely change greatly in botanical composition, since the C{sub 4} dominants responded to elevated CO{sub 2} more than the C{sub 3} subdominants.

  19. Emotional response towards food packaging

    DEFF Research Database (Denmark)

    Liao, Lewis Xinwei; Corsi, Armando M.; Chrysochou, Polymeros


    In this paper we investigate consumers’ emotional responses to food packaging. More specifically, we use self-report and physiological measures to jointly assess emotional responses to three typical food packaging elements: colours (lowwavelength vs. high-wavelength), images (positive vs. negative......) and typefaces (simple vs. ornate). A sample of 120 participants was exposed to mock package design concepts of chocolate blocks. The results suggest that images generate an emotional response that can be measured by both self-report and physiological measures, whereas colours and typefaces generate emotional...... response that can only be measured by self-report measures. We propose that a joint application of selfreport and physiological measures can lead to richer information and wider interpretation of consumer emotional responses to food packaging elements than using either measure alone....

  20. Mapping 'Social Responsibility' in Science

    DEFF Research Database (Denmark)

    Glerup, Cecilie; Horst, Maja


    aims to exclude the social from the scientific production in order to make it objective and thereby responsible; the Reflexivity rationality, which sees it as science's responsibility to let itself be guided by problems in society in choice of research focus and methods; the Contribution rationality......, which insists that responsible science should live up to public demands for innovation and democracy; and the Integration rationality, which advocates that science should be co-constructed with societal actors in order to be socially responsible. While each rationality is distinct, the article argues......This article employs the Foucauldian notion of ‘political rationality’ to map discussions and ideals about the responsibility of science toward society. By constructing and analyzing an archive of 263 journal papers, four political rationalities were identified: the Demarcation rationality, which...

  1. Electric response in superfluid helium (United States)

    Chagovets, Tymofiy V.


    We report an experimental investigation of the electric response of superfluid helium that arises in the presence of a second sound standing wave. It was found that the signal of the electric response is observed in a narrow range of second sound excitation power. The linear dependence of the signal amplitude has been derived at low excitation power, however, above some critical power, the amplitude of the signal is considerably decreased. It was established that the rapid change of the electric response is not associated with a turbulent regime generated by the second sound wave. A model of the appearance of the electric response as a result of the oscillation of electron bubbles in the normal fluid velocity field in the second sound wave is presented. Possible explanation for the decrease of the electric response are presented.

  2. Response of Vegetation in Northern China to Global Warming (United States)

    Cui, H.; Huang, R.


    During the last 30 years, the warmth index (WI) (Kira, 1945) has increased by 10 to 20 points in northern China and the humid index (HI) (Xu,1985) correspondingly decreased by 1 to 2 points. Accordingly, the green leaf stage of plants and herbs around Beijing prolonged from late Nov. to mid-Dec. The phenophase has also been changed, e.g., the most enjoyable period of red leaves such as common smoketree (Cotinus coggygria) and maple (Acer mono and A.truncatum) has postponed for 10 days and the blooming period of flowering plants has also advanced for the same span. Some plants, e.g. japanese pagodatree (Sophora japonica) and hispid locust (Robinia hispida) even blossom again in fall. Some evergreen and thermophilic plants have also been planted to further north. Rice (Oryza sativa) have extended to around 49 degree N and, as an extreme case, to 52 degree N (Huma County, Heilongjiang Province), and tea (Camellia sinensis) from around 35 to 36.5 degree N. River basins of Songhuajiang and Nenjiang in Heilongjiang Province become important rice production bases. Rizhao and Qingdao in Shandong province become famous tea production bases. Before 1970s, evergreen broadleaf woody plants were rarely cultivated in Beijing. But now such plants as privet (Lygustrum lucidum), magnolia (Magnolia grandiflora), evergreen euonymus (Euonymus japonicus), and boxwood (Buxus sinica var. margaritacea) all live there through the winter. Many thermophilic garden plants, such as fig (Ficus carica), Chinese tulip tree (Liliodendron chinense), Chinese photinia (Photinia serrulata), crape myrtle (Lagerstroemia indica), and plum blossom (Prunus mume) are also successively cultivated outdoors in Beijing. Common papermulberry (Broussonetia papirifera) gradually increases and even becomes subdominant species of deciduous forest during last 30 years in the piedmont around Beijing. The cultivation boundary of some thermophilic trees, e.g., Chinese catalpa (Catalpa ovata), japanese pagodatree

  3. Heterophony and hyper-responsibility

    DEFF Research Database (Denmark)

    Knudsen, Hanne; Andersen, Niels Åkerstrøm


    One of the current challenges facing the health system is that it depends on non-health factors as it recognises that the individual's health depends not only on nutrition and sporting activity but also on factors such as their job, family situation and level of education. This makes it difficult...... for the health system to take responsibility for defining what health responsibility includes. Therefore, since the late 1980s, one of the governing ambitions of the health system has been to make citizens responsible for their own situation....

  4. Transcompartmental Inflammatory Responses in Humans

    DEFF Research Database (Denmark)

    Plovsing, Ronni R; Berg, Ronan M G; Evans, Kevin A


    OBJECTIVES: Transcompartmental signaling during early inflammation may lead to propagation of disease to other organs. The time course and the mechanisms involved are still poorly understood. We aimed at comparing acute transcompartmental inflammatory responses in humans following lipopolysacchar......OBJECTIVES: Transcompartmental signaling during early inflammation may lead to propagation of disease to other organs. The time course and the mechanisms involved are still poorly understood. We aimed at comparing acute transcompartmental inflammatory responses in humans following......-α, interleukin-6, and albumin (all p humans is followed by a transcompartmental proinflammatory response, the degree and differential...

  5. Responses of elderly spouse caregivers. (United States)

    Given, B; Stommel, M; Collins, C; King, S; Given, C W


    In this paper three categories of variables were identified to predict spouses' reactions to caregiving roles: patient characteristics, the caregiving environment, and characteristics of the caregiver. Measures of these variables were administered to 159 spouse caregivers. Four domains of caregivers' responses were identified: negative emotional reactions, feelings of responsibility for the patient, feelings of abandonment by family, and impact of caregiving on daily schedules. These domains were influenced most by patient negative behaviors, physical health, and age, and by caregiver age, employment, and emotional status. Amount of assistance, affective support, and hours of care also were predictive of spouse responses.

  6. The 2010 Haiti earthquake response. (United States)

    Raviola, Giuseppe; Severe, Jennifer; Therosme, Tatiana; Oswald, Cate; Belkin, Gary; Eustache, Eddy


    This article presents an overview of the mental health response to the 2010 Haiti earthquake. Discussion includes consideration of complexities that relate to emergency response, mental health and psychosocial response in disasters, long-term planning of systems of care, and the development of safe, effective, and culturally sound mental health services in the Haitian context. This information will be of value to mental health professionals and policy specialists interested in mental health in Haiti, and in the delivery of mental health services in particularly resource-limited contexts in the setting of disasters. Copyright © 2013 Elsevier Inc. All rights reserved.

  7. Emergency Response and Management Activities (United States)

    This quarterly report, highlighting accomplishments over the past several months, showcases EPA’s unique emergency response capabilities through the use of cutting-edge technologies and innovative cleanup strategies.

  8. GBM Response Matrix FITS Files (United States)

    National Aeronautics and Space Administration — Time-dependent detector response matrices for each GBM detector covering the duration of every GBM flare. Needed in the spectral analysis software to relate observed...

  9. Identification of noisy response latency

    DEFF Research Database (Denmark)

    Tamborrino, Massimiliano; Ditlevsen, Susanne; Lansky, Petr


    be highly unreliable, unless the background signal is accounted for in the analysis. In fact, if the background signal is ignored, however small it is compared to the response and however large the delay is, the estimate of the time delay will go to zero for any reasonable estimator when increasing......In many physical systems there is a time delay before an applied input (stimulation) has an impact on the output (response), and the quantification of this delay is of paramount interest. If the response can only be observed on top of an indistinguishable background signal, the estimation can...... the number of observations. Here we propose a unified concept of response latency identification in event data corrupted by a background signal. It is done in the context of information transfer within a neural system, more specifically on spike trains from single neurons. The estimators are compared...

  10. Corporate Social Responsibility in Afghanistan

    DEFF Research Database (Denmark)

    Azizi, Sameer

    This doctoral dissertation examines the business-development relations in Afghanistan by focusing on Corporate Social Responsibility (CSR) and other related practices from corporations in the Afghan mobile telecommunications industry. More concretely, the study aims to explore the characteristics...

  11. Dapsone responsive juvenile pemphigus foliaceus

    Directory of Open Access Journals (Sweden)

    Gautam R


    Full Text Available An 8-year-old girl of Pemphigus foliaceus is reported because of the rarity of the condition in childhood. The disease was resistant to steroids and showed a dramatic response to dapsone.

  12. Response to Kuhse [with Commentary

    National Research Council Canada - National Science Library

    R. M. Perkin; D. B. Resnik; H. Kuhse


    ...: is the last gasp necessary?. A common thread in both Hawryluck's and Kuhse's responses is the difficulties encountered when using the agent's intentions to make moral distinctions between using neuromuscular blocking drugs...

  13. Mapping "Social Responsibility" in Science

    DEFF Research Database (Denmark)

    Horst, Maja; Glerup, Cecilie

    The paper investigates the discourse on social responsibility in science as it appears in academic journals. Through database searches a collection of more than 300 papers have been analysed in order to map their answers to the following three questions: - What is the central problem that threatens...... of social responsibility of science imply different forms of governance of and within science. The paper employs a Foucaldian discourse analysis to understand how a particular conceptualisation of responsibility implies a political rationality, i.e. a particular form of governance of science. The analysis...... responsibility in science? - What are the central aspects of science or its relation to society that need to be regulated or changed? - What kinds of solutions are imagined and how are these solutions supposed to be put into place? On this basis the paper explores how different interpretations of the notion...

  14. Quantal Response: Estimation and Inference (United States)


    Application to Quantal Response 3.1 The Quantal Response Model In the quantal response (QR) model ,11 the response is a binary (Bernoulli) random variable y...inverse of P. With p = G(a+bx), then Q(p) = a+bx and X(p) = Q(p)−a b . (79) Common choices for the link G include the logistic cdf for the logit model ...x−m s ) . (84) where bs = 1 and a =−bm. Then X(p) = m+ Q(p) b = m+ sQ(p) . (85) If G(0) = 1/2, as it does for the logit and probit models , then P(m

  15. EPA’s Response Techniques (United States)

    Done through 10 regional office and in close cooperation with a network of federal, state, and local governments. First they investigate the site, then determine response alternatives and safety measures, considering hazards and exposure pathways.

  16. Corporate responsibility and the media


    Grayson, David


    This paper discusses how CR is covered in the media and the media’s own corporate responsibilities, covering both traditional and new media. Co published with Centrum fur Corporate Citizenship Deutschland

  17. Thrips responses to plant odours


    Kogel, de, W.J.; Koschier, E.H.


    Thrips responses to plant odour compounds were assessed using a Y-tube olfactometer. Several compounds were attractive to adult Frankliniella occidentalis females, since the majority walked towards the odour source. Some odours that were attractive for western flower thrips appeared to be non-attractive for Thrips tabaci and visa versa. Chrysanthemum buds or flowers that were used as an odour source in the olfactometer elicited no positive response from western flower thrips. In wind tunnel e...

  18. Chromosomal instability determines taxane response

    DEFF Research Database (Denmark)

    Swanton, C.; Nicke, B.; Schuett, M.


    Microtubule-stabilizing (MTS) agents, such as taxanes, are important chemotherapeutics with a poorly understood mechanism of action. We identified a set of genes repressed in multiple cell lines in response to MTS agents and observed that these genes are overexpressed in tumors exhibiting chromos...... resistance but carboplatin sensitivity, indicating that CIN may determine MTS response in vivo. Thus, pretherapeutic assessment of CIN may optimize treatment stratification and clinical trial design using these agents....

  19. Anchoring Vignettes and Response Consistency


    Arie Kapteyn; Smith, James P.; Arthur van Soest


    The use of anchoring vignettes to correct for differential item functioning rests upon two identifying assumptions: vignette equivalence and response consistency. To test the second assumption the authors conduct an experiment in which respondents in an Internet panel are asked to both describe their health in a number of domains and rate their health in these domains. In a subsequent interview respondents are shown vignettes that are in fact descriptions of their own health. Under response c...

  20. Distributed Dynamic Condition Response Structures

    DEFF Research Database (Denmark)

    Hildebrandt, Thomas; Mukkamala, Raghava Rao

    We present distributed dynamic condition response structures as a declarative process model inspired by the workflow language employed by our industrial partner and conservatively generalizing labelled event structures. The model adds to event structures the possibility to 1) finitely specify...... as a labelled transition system. Exploration of the relationship between dynamic condition response structures and traditional models for concurrency, application to more complex scenarios, and further extensions of the model is left to future work....

  1. Reforming Disaster and Emergency Response (United States)


    St ra te gy R es ea rc h Pr oj ec t REFORMING DISASTER AND EMERGENCY RESPONSE BY COLONEL MARK D. JOHNSON United States Army...From - To) 4. TITLE AND SUBTITLE Reforming Disaster and Emergency Response 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...the Federal Emergency Management Agency (FEMA) has focused too much on day- to-day disasters , from snow storms to forest fires, tripling the number

  2. business ethics and social responsibility


    Lačná, Silvia


    This Bachelor Thesis focuses mainly on the business ethics and social responsibility. It is divided into two parts: theoretical and practical. The theoretical part examines the relationship of business ethics and social responsibility and the ways of their implementation in enterprises in the Czech Republic. The practical part consists of research focuses on the social and ethical environment in particular selected company. It is divided into three sections: the relationship between employees...

  3. Sequence conservation of subdominant HLA-A2-binding CTL epitopes in HIV-1 clinical isolates and CD8+ T-lymphocyte cross-recognition may explain the immune reaction in infected individuals

    DEFF Research Database (Denmark)

    Thorn, Mette; Tang, Sheila; Therrien, Dominic


    Cytotoxic T-lymphocytes (CTL) are critical for immune control of infection with human immunodeficiency virus type-1 (HIV-1) and searches for relevant CTL epitopes for immune therapy are ongoing. Recently, we identified 28 HLA-A2-binding HIV-1 CTL epitopes (1). In this follow-up study we fully gen...... that T-cell promiscuity may explain the observed CD8(+) T-cell reaction to epitope variants and it may be possible to use the selected immune optimized epitope peptides for therapeutic vaccination....

  4. Response to commentators of "a critique of positive responsibility". (United States)

    Stieb, James A


    It has been claimed that (1) computer professionals should be held responsible for an undisclosed list of "undesirable events" associated with their work and (2) most if not all computer disasters can be avoided by truly understanding responsibility. Commentators of "A Critique of Positive Responsibility in Computing" argue that this is not Donald Gotterbarn's view (Gotterbarn, JSEE 14(2):235-239, 2008) but that a critique of the view nevertheless raises significant moral issues within computing such as the ethical goals of a computing profession, the appropriate ethical stance toward bugs, and the public good with respect to computing (Miller, JSEE 14(2):245-249, 2008). Commentators also argue that "A Critique"'s "profitable misreading" demonstrates the "moral ecology" of organizations "dedicated narrowly to financial success" and that other "moral ecologies" that are customer or quality driven can be shown to be more important or preeminent (Huff, JSEE 14(2):241-244, 2008). It is argued here that (1) the hyper-inflated reading of Gotterbarn's and Ladd's views on positive responsibility persists despite Gotterbarn's explicit rejection of it, and that (2) such a reading of positive responsibility cannot be placed within a single moral ecology, nor can a single moral ecology be shown to be any more important or preeminent than others.

  5. Differential lung NK cell responses in avian influenza virus infected chickens correlate with pathogenicity. (United States)

    Jansen, Christine A; de Geus, Eveline D; van Haarlem, Daphne A; van de Haar, Peter M; Löndt, Brandon Z; Graham, Simon P; Göbel, Thomas W; van Eden, Willem; Brookes, Sharon M; Vervelde, Lonneke


    Infection of chickens with low pathogenicity avian influenza (LPAI) virus results in mild clinical signs while infection with highly pathogenic avian influenza (HPAI) viruses causes death of the birds within 36-48 hours. Since natural killer (NK) cells have been shown to play an important role in influenza-specific immunity, we hypothesise that NK cells are involved in this difference in pathogenicity. To investigate this, the role of chicken NK-cells in LPAI virus infection was studied. Next activation of lung NK cells upon HPAI virus infection was analysed. Infection with a H9N2 LPAI virus resulted in the presence of viral RNA in the lungs which coincided with enhanced activation of lung NK cells. The presence of H5N1 viruses, measured by detection of viral RNA, did not induce activation of lung NK cells. This suggests that decreased NK-cell activation may be one of the mechanisms associated with the enhanced pathogenicity of H5N1 viruses.

  6. Responsible Quality at Casall : Evaluating Corporate Social Responsibility Projects


    Jakobsson, Kim; Klavebäck, Sofia; Nehm, Tobias


    Much research has been conducted within Corporate Social Responsibility (CSR), and it is currently a highly debated topic. Today, CSR is not only pursued in response to public pressure, but is also seen as a source of competitive advantage and differentiation. The problem that this thesis deals with is that many SMEs do not use CSR as a proactive competitive tool in a strategic manner. Therefore, the purpose of this thesis is to develop an evaluation framework for SME‟s CSR projects, and to u...

  7. Corporate social responsibility and the economics of consumer social responsibility


    Etilé, Fabrice; Teyssier, Sabrina


    La diffusion de la Responsabilité sociale des entreprises (CSR) est conditionnée par les comportements d’achat des consommateurs. Nombre d’entre eux déclarent être favorables à la CSR et pourtant, la consommation responsable reste à un niveau faible. Cette revue de la littérature analyse deux barrières principales à la consommation responsable : la disponibilité-à-payer des consommateurs, qui dépend de leurs préférences sociales ; et l’asymétrie d’information entre les entreprises et les cons...

  8. Response

    CERN Multimedia

    CERN. Geneva


    ALICE is the LHC experiment dedicated to the study of Heavy Ion collisions. In particular, the detector features low momentum tracking and vertexing, and comprehensive particle identification capabilities. In a single central heavy ion collision at the LHC, thousands of particles per unit rapidity are produced, making the data volume, track reconstruction and search of rare signals particularly challenging. Data science and machine learning techniques could help to tackle some of the challenges outlined above. In this talk, we will discuss some early attempts to use these techniques for the processing of detector signals and for the physics analysis. We will also highlight the most promising areas for the application of these methods.

  9. Response

    CERN Multimedia

    CERN. Geneva


    Neuromorphic silicon chips have been developed over the last 30 years, inspired by the design of biological nervous systems and offering an alternative paradigm for computation, with real-time massively parallel operation and potentially large power savings with respect to conventional computing architectures. I will present the general principles with a brief investigation of the design choices that have been explored, and I'll discuss how such hardware has been applied to problems such as classification.

  10. Response

    CERN Multimedia

    CERN. Geneva


    Stochastic optimization, among which bio-inspired algorithms, is gaining momentum in areas where more classical optimization algorithms fail to deliver satisfactory results, or simply cannot be directly applied. This presentation will introduce baseline stochastic optimization algorithms, and illustrate their efficiency in different domains, from continuous non-convex problems to combinatorial optimization problem, to problems for which a non-parametric formulation can help exploring unforeseen possible solution spaces.

  11. Response

    CERN Multimedia

    CERN. Geneva


    Starting from a brief historical perspective on scientific discovery, this talk will review some of the theory and open problems of deep learning and describe how to design efficient feedforward and recursive deep learning architectures for applications in the natural sciences. In particular, the focus will be on multiple particle problems at different scales: in biology (e.g. prediction of protein structures), chemistry (e.g. prediction of molecular properties and reactions), and high-energy physics (e.g. detection of exotic particles, jet substructure and tagging, "dark matter and dark knowledge")

  12. responsibility

    African Journals Online (AJOL)

    tones of gathering lots of people together to share food, drink, music, song and dance, laughter, sadness and ... Activities of the Zimbabwean theatre are overseen by the Ministry of Sports, Recre- ation and Culture. ..... dren perform the full range of CHIPAWO performances - plays, dances, music and songs”. Apart from the ...

  13. Heart rate response to breathing

    DEFF Research Database (Denmark)

    Mehlsen, J; Pagh, K; Nielsen, J S


    Heart rate responses to stepwise and periodic changes in lung volume were studied in seven young healthy males. Stepwise inspiration and expiration both resulted in an increase in heart rate followed by a rapid decrease in heart rate. The fastest heart rate was reached in 1.6 +/- 0.5 s and in 3.......6 +/- 1.4 s in response to inspiration and expiration, respectively (P less than 0.01). The slowest heart rate was reached in 4.8 +/- 1.0 s and in 7.6 +/- 1.9 s in response to inspiration and expiration, respectively (P less than 0.01). Following this biphasic change the heart rate returned to a steady...... level. The difference between the fastest and the slowest heart rates was significantly larger in response to inspiration (21.7 +/- 7.3 beats per minute) than in response to expiration (12.0 +/- 7.3 beats per minute; P less than 0.01). Periodic changes in lung volume were performed with frequencies from...

  14. Stimulus ambiguity elicits response conflict. (United States)

    Szmalec, Arnaud; Verbruggen, Frederick; Vandierendonck, André; De Baene, Wouter; Verguts, Tom; Notebaert, Wim


    Conflict monitoring theory [M.M. Botvinick, T. Braver, D. Barch, C. Carter, J.D. Cohen, Conflict monitoring and cognitive control, Psychol. Rev. 108 (2001) 625-652] assumes that perceptual ambiguity among choice stimuli elicits response conflict in choice reaction. It hence predicts that response conflict is also involved in elementary variants of choice reaction time (RT) tasks, i.e., those variants that, by contrast with the Stroop task or the Go/No-Go task for instance, are rarely associated with cognitive control. In order to test this prediction, an experiment was designed in which participants performed a simple RT task and a regular between-hand 2-choice RT task under three different levels of stimulus ambiguity. The data show that response conflict, as measured by the N2 component of the event-related brain potential (ERP), was elicited in the 2-choice RT task but not in the simple RT task and that the degree of response conflict in the 2-choice RT task was a function of stimulus ambiguity. These results show that response conflict is also present in a regular choice RT task which is traditionally not considered to be a measure of cognitive conflict.

  15. Corporate Social Responsibility in Aviation (United States)

    Phillips, Edwin D.


    The dialog within aviation management education regarding ethics is incomplete without a discussion of corporate social responsibility (CSR). CSR research requires discussion involving: (a) the current emphasis on CSR in business in general and aviation specifically; (b) business and educational theory that provide a basis for aviation companies to engage in socially responsible actions; (c) techniques used by aviation and aerospace companies to fulfill this responsibility; and (d) a glimpse of teaching approaches used in university aviation management classes. The summary of this research suggests educators explain CSR theory and practice to students in industry and collegiate aviation management programs. Doing so extends the discussion of ethical behavior and matches the current high level of interest and activity within the aviation industry toward CSR.

  16. Integrated Stress Responses in Salmonella (United States)

    Shen, Shu; Fang, Ferric C.


    The foodborne gram-negative pathogen Salmonella must adapt to varied environmental conditions encountered within foods, the host gastrointestinal tract and the phagosomes of host macrophages. Adaptation is achieved through the coordinate regulation of gene expression in response to environmental signals such as temperature, pH, osmolarity, redox state, antimicrobial peptides, and nutrient deprivation. This review will examine mechanisms by which the integration of regulatory responses to a broad array of environmental signals can be achieved. First, in the most straightforward case, tandem promoters allow gene expression to respond to multiple signals. Second, versatile sensor proteins may respond to more than one environmental signal. Third, transcriptional silencing and counter-silencing as demonstrated by the H-NS paradigm provides a general mechanism for the convergence of multiple regulatory inputs. Fourth, signaling cascades allow gene activation by independent sensory elements. These mechanisms allow Salmonella to utilize common adaptive stress pathways in response to a diverse range of environmental conditions. PMID:21570144

  17. Responsiveness of Clinical Outcome Measures

    DEFF Research Database (Denmark)

    Lauridsen, Henrik Hein

    subgroups of patients with LBP. In addition, we explored whether low back pain patients were able to determine an acceptable treatment outcome before it began. Methods The responsiveness in subgroups study. An extensive cross-cultural adaptation and validation of the ODI was carried out on patients seen...... in SeS and leg pain patients. Moreover, patients' retrospective evaluation of treatment effect was more responsive in PrS patients compared to serial measurements. The prospective acceptable outcome study. The prospective acceptable outcome method was reproducible. The MCIDpre was outside instrument...... measurement error and 1.5-4.5 times larger compared to the MCIDpost. Furthermore, the MCIDpre was almost comparable to patients' post-treatment acceptable change, but only for the pain scale. Conclusion The Danish version of the ODI is a reliable, valid and responsive HMS which is psychometrically more...

  18. Stress Response of Granular Systems (United States)

    Ramola, Kabir; Chakraborty, Bulbul


    We develop a framework for stress response in two dimensional granular media, with and without friction, that respects vector force balance at the microscopic level. We introduce local gauge degrees of freedom that determine the response of contact forces between constituent grains on a given, disordered, contact network, to external perturbations. By mapping this response to the spectral properties of the graph Laplacian corresponding to the underlying contact network, we show that this naturally leads to spatial localization of forces. We present numerical evidence for localization using exact diagonalization studies of network Laplacians of soft disk packings. Finally, we discuss the role of other constraints, such as torque balance, in determining the stability of a granular packing to external perturbations.

  19. Risk, responsibility and political action

    DEFF Research Database (Denmark)

    Halskov Jensen, Elisabeth


    ABSTRACT. This paper presents an argumentative case study of the discursive representation of risk, responsibility and political action in the Spanish media. The study uses a critical discourse analytical approach combined with theories on risk, agency and political communication in the media...... in discourse. Discourse analysis shows that in the Spanish newspaper sample the focus was on the construal of high risk and on the construal of the national Spanish politicians, the EU and the Brit-ish nation as scapegoats. No responsibility was associated with consumers or other individual players. Political....... It is argued that an application of the Toulmin model is useful for eliciting systematic overall repre-sentations of responsibility and agency in environmental crises such as the mad cow crisis as well as for revealing relationships between social domains such as moral, politics, economics and science...

  20. "Responsibility in Mobility": International Students and Social Responsibility (United States)

    Tran, Ly Thi; Vu, Thao Thi Phuong


    Enhancing the educational experience and social connectedness for international students is the responsibility of different involved parties among whom international students themselves and host institutions play a key role. However, the question of how the condition of cross-border mobility has shaped and re-shaped international students'…

  1. Medical Response to Haiti Earthquake: Operation Unified Response (United States)


    Employ EMF -150 Evacuation of Haitians Resumes Definitive Care Components of NDMS Activated AE Review Board Established USS VINSON Departs 153rd Blood...daily USG health meetings to pass information from UN Health Cluster and prioritize USG medical response. • Operational Environmental Risk Surveillance

  2. Conditional autonomy and responsible Action: A response to Yusef ...

    African Journals Online (AJOL)

    Yusef Waghid in his response to Martin Hall argues that Martin Hall offers a better way of making sense of some of the conceptual and pragmatic links between academic freedom and institutional autonomy. Nevertheless Waghid critiques Hall's uncritical treatment of prominent theoretical positions for his claims, which ...

  3. Response: Critical Realism--Response to Longhofer and Floersch (United States)

    Briar-Lawson, Katharine


    This article addresses key challenges posed by critical realism, proposed by Longhofer and Floersch, as a philosophical underpinning for a science of social work. As a response to Longhofer and Floersch, it is argued that critical realism may be instructive in debates about structural conditions that dictate more inclusive interventions and…

  4. Building Fluent Performance: Measuring Response Rate and Multiplying Response Opportunities (United States)

    Binder, Carl


    Precision teaching emerged from O.R. Lindsley's pristine application of Skinner's natural science of behavior, with a focus on response rate measurement and free operant procedures. When applied with human learners in instructional settings, these first principles led to a series of developments framed in this paper as four kinds of ceilings that…

  5. Counterconditioned Fear Responses Exhibit Greater Renewal than Extinguished Fear Responses (United States)

    Holmes, Nathan M.; Leung, Hiu T.; Westbrook, R. Frederick


    This series of experiments used rats to compare counterconditioning and extinction of conditioned fear responses (freezing) with respect to the effects of a context shift. In each experiment, a stimulus was paired with shock in context A, extinguished or counterconditioned through pairings with sucrose in context B, and then tested for renewal…

  6. Climate Migration and Moral Responsibility. (United States)

    Nawrotzki, Raphael

    Even though anthropogenic climate change is largely caused by industrialized nations, its burden is distributed unevenly with poor developing countries suffering the most. A common response to livelihood insecurities and destruction is migration. Using Peter Singer's "historical principle" this paper argues that a morally just evaluation requires taking causality between climate change and migration under consideration. The historical principle is employed to emphasize shortcomings in commonly made philosophical arguments to oppose immigration. The article concludes that none of these arguments is able to override the moral responsibility of industrialized countries to compensate for harms that their actions have caused.

  7. The Social Responsibility of Enterprises

    DEFF Research Database (Denmark)

    Rosdahl, Anders

    One of the main themes in the research program concerns the social responsibility of enterprises. The present working paper discusses this concept from a number of different angles. The working paper is part of process aimed at clarifying what may be meant by social responsibility of enterprises....... In the paper both common sense conceptions, sociological and economic perspectives are indicated. The conclusion is that the research program must take a social and labour market oriented conception as its point of departure and that both rational choice and cultural perspectives should be considered...

  8. Neuronal responses to physiological stress

    DEFF Research Database (Denmark)

    Kagias, Konstantinos; Nehammer, Camilla; Pocock, Roger David John


    damage during aging that results in decline and eventual death. Studies have shown that the nervous system plays a pivotal role in responding to stress. Neurons not only receive and process information from the environment but also actively respond to various stresses to promote survival. These responses...... include changes in the expression of molecules such as transcription factors and microRNAs that regulate stress resistance and adaptation. Moreover, both intrinsic and extrinsic stresses have a tremendous impact on neuronal development and maintenance with implications in many diseases. Here, we review...... the responses of neurons to various physiological stressors at the molecular and cellular level....


    Rosso, Anna Maria; Chiorri, Carlo; Denevi, Simona


    In this study, three different subtypes of Space responses to the Rorschach test were hypothesized: S-fusion, S-reversal, and S-integration. The relationship between these subtypes and feelings of anger and aggression was investigated. The Rorschach test, the State-Trait Anxiety Inventory-2 (STAXI-2), and the Aggression Questionnaire (AQ) were administered to 50 university students. Scores on the STAXI-2 were positively associated with S-fusion and negatively associated with S-integration. No significant associations of S subtypes with aggression were found. The findings support the hypothesis that different figure-ground relationships, shown in the subtypes of S responses, indicate different psychological processes.

  10. Clinical interpretation of leukocyte responses. (United States)

    Latimer, K S; Rakich, P M


    Basic information has been presented concerning leukocyte (neutrophil, monocyte, lymphocyte, eosinophil, and basophil) function, production, kinetics, and response to various physiological and disease states. Using this information, veterinary practitioners should be able to interpret leukogram data from sick and healthy dogs and cats. Specifically, characteristic leukogram patterns such as physiological leukocytosis, corticosteroid-associated changes, and the presence of infection or severe inflammation should be recognized. In addition, interpretation of individual leukocyte responses should be possible. Several tables have been provided to assist in constructing a differential diagnosis to explain increases or decreases in absolute leukocyte numbers that lie outside of expected reference intervals.

  11. Partiality of Responsibility: Ethics in Sustainability Consulting

    NARCIS (Netherlands)

    Earhart, R.S.


    Sustainability, Socially Responsible Investment (SRI) and Corporate Social Responsibility (CSR) are both highly normative fields of professional practice, framed by various narratives: capitalist versus environmentalist, waste versus respect for the planet, consumerism versus responsibility;

  12. Cortical Response of Retardates for AER Audiometry (United States)

    Hogan, Donald D.


    Averaged auditory evoked responses were obtained from 15 retarded and motor-handicapped subjects and from 15 nonretarded subjects in order to investigate comparative responsiveness and response features. (Author)

  13. Responses of plants to air pollution

    National Research Council Canada - National Science Library

    Mudd, J. Brian; Kozlowski, T. T


    .... KOZLOWSKI Pollution, 1975 ELROY L. RICE. Allelopathy, (Eds.). Fire and Ecosystems, 1974 (Eds.). Responses of Plants to Air Responses of Plants to Air PollutionRESPONSES OF PLANTS TO AIR POLLUTION E...

  14. 7 CFR 3407.4 - Responsibilities. (United States)


    ... indicated: (a) Administrator. The Administrator is responsible for providing leadership, formulating agency... Deputy Administrators are responsible for: (1) Ensuring that eligible institutions under CSREES formula..., and formula projects. (c) Program Managers. CSREES Program Managers are responsible for: (1) Preparing...

  15. Superior Responsibility in International Criminal Law


    Lindeman, Lars


    International humanitarian law places a duty on leaders to ensure that their subordinates respect the rules of armed conflict during their actions. International law provides two primary bases for holding a person criminally responsible: personal criminal responsibility and superior responsibility. This is a study into the latter form of responsibility. Superior responsibility (or command responsibility) is a form of criminal liability, which can be used to establish the criminal responsibili...

  16. The Social Responsibility of Enterprises

    DEFF Research Database (Denmark)

    Rosdahl, Anders

    More than 20 per cent of the Danish working age population is provided for by some form of public income transfer. The goal of the present government is that enterprises should employ more of these persons: Enterprises should become more socially responsible. The paper analyses enterprises...

  17. Preparing Engineers for Social Responsibility (United States)

    Zandvoort, H.


    In this paper I introduce the contributions to a special section of the journal: one devoted to the question of how engineering curricula can or should contribute to the preparation of graduates for socially responsible decision making and conduct. The special section is motivated by the circumstance that, although there is broad agreement that…

  18. Mechanical Response of Thermoelectric Materials

    Energy Technology Data Exchange (ETDEWEB)

    Wereszczak, Andrew A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Case, Eldon D. [Michigan State Univ., East Lansing, MI (United States)


    A sufficient mechanical response of thermoelectric materials (TEMats) to structural loadings is a prerequisite to the exploitation of any candidate TEMat's thermoelectric efficiency. If a TEMat is mechanically damaged or cracks from service-induced stresses, then its thermal and electrical functions can be compromised or even cease. Semiconductor TEMats tend to be quite brittle and have a high coefficient of thermal expansion; therefore, they can be quite susceptible to mechanical failure when subjected to operational thermal gradients. Because of this, sufficient mechanical response (vis-a-vis, mechanical properties) of any candidate TEMat must be achieved and sustained in the context of the service-induced stress state to which it is subjected. This report provides an overview of the mechanical responses of state-of-the-art TEMats; discusses the relevant properties that are associated with those responses and their measurement; and describes important, nonequilibrium phenomena that further complicate their use in thermoelectric devices. For reference purposes, the report also includes several appendixes that list published data on elastic properties and strengths of a variety of TEMats.

  19. Caenorhabditis elegans response to salt

    NARCIS (Netherlands)

    O.O. Umuerri (Oluwatoroti Omowayewa)


    textabstractThis thesis describes my work, where I used genetic methods to identify new genes involved in salt taste in C. elegans. In addition, I used calcium imaging to characterize the cellular response of C. elegans to salt. The thesis is divided into five sections and each section is summarized

  20. Responsive media in HTML5

    CERN Document Server

    Libby, Alex


    If you are a web designer with a good understanding of CSS, jQuery, and HTML, but new to creating responsive sites, then this book is for you. The prerequisite is a good understanding of CSS and HTML; the demos will suit those who have some prior knowledge of Less CSS, WordPress, or Bootstrap.

  1. Adolescent Suicide: One School's Response. (United States)

    Adams, Cheryll M.


    This article documents the responses of a state-supported residential high school for gifted students following the 1994 suicides of three students. The school's measures to develop a screening procedure, design a prevention program, disseminate information about adolescent suicide, and host a conference are outlined, as is a separate crisis…

  2. Predicting response to epigenetic therapy

    DEFF Research Database (Denmark)

    Treppendahl, Marianne B; Sommer Kristensen, Lasse; Grønbæk, Kirsten


    of good pretreatment predictors of response is of great value. Many clinical parameters and molecular targets have been tested in preclinical and clinical studies with varying results, leaving room for optimization. Here we provide an overview of markers that may predict the efficacy of FDA- and EMA...

  3. Incumbent response to disruptive innovation

    DEFF Research Database (Denmark)

    Kaulio, Matti; Thorén, Kent; Rohrbeck, René

    This article presents a preliminary analysis of a retrospective longitudinal case study of an incumbent, the Swedish-Finnish Telecom operator TeliaSonera AB, with focus on its responses to technical and business model change. Findings nuance the general understanding of Telco’s as passive actors...

  4. Partnerships for corporate social responsability

    NARCIS (Netherlands)

    Bruijn, de T.J.N.M. (Theo)


    The purpose of this paper is to conceptualise the extent to which partnerships with non-governmental organisations (NGOs) are a necessity for successful efforts of businesses in the area of corporate social responsibility (CSR). The main findings are based on an analysis of existing literature on

  5. Response to David Temperley's Commentary

    Directory of Open Access Journals (Sweden)

    William Thomson


    Full Text Available The author responds to points raised in David Temperley’s commentary, which appeared in Vol. 1, No. 2 of Empirical Musicology Review. The response includes a discussion of strengths and limitations of atemporal models of musical perception, with particular attention to presentations such as those of Carol Krumhansl and Fred Lerdahl.

  6. Thrips responses to plant odours

    NARCIS (Netherlands)

    Kogel, de W.J.; Koschier, E.H.


    Thrips responses to plant odour compounds were assessed using a Y-tube olfactometer. Several compounds were attractive to adult Frankliniella occidentalis females, since the majority walked towards the odour source. Some odours that were attractive for western flower thrips appeared to be

  7. Perceptions of Corporate Social Responsibility (United States)

    Gavin, James F.; Maynard, William S.


    This study investigated the possible implications of Corporate Social Responsibility (CSR) for employee expectations and satisfactions. Specifically, interest centered on the question of how perceptions of an organization's involvement in the resolution of current societal problems might relate to members' expectations of equitable job rewards and…

  8. Criminal Responsibility in International Law

    NARCIS (Netherlands)

    van Sliedregt, E.


    This book examines the concept of individual criminal responsibility for serious violations of international law, i.e. aggression, genocide, crimes against humanity and war crimes. Such crimes are rarely committed by single individuals. Rather, international crimes generally connote a plurality of

  9. Auxin response under osmotic stress. (United States)

    Naser, Victoria; Shani, Eilon


    The phytohormone auxin (indole-3-acetic acid, IAA) is a small organic molecule that coordinates many of the key processes in plant development and adaptive growth. Plants regulate the auxin response pathways at multiple levels including biosynthesis, metabolism, transport and perception. One of the most striking aspects of plant plasticity is the modulation of development in response to changing growth environments. In this review, we explore recent findings correlating auxin response-dependent growth and development with osmotic stresses. Studies of water deficit, dehydration, salt, and other osmotic stresses point towards direct and indirect molecular perturbations in the auxin pathway. Osmotic stress stimuli modulate auxin responses by affecting auxin biosynthesis (YUC, TAA1), transport (PIN), perception (TIR/AFB, Aux/IAA), and inactivation/conjugation (GH3, miR167, IAR3) to coordinate growth and patterning. In turn, stress-modulated auxin gradients drive physiological and developmental mechanisms such as stomata aperture, aquaporin and lateral root positioning. We conclude by arguing that auxin-mediated growth inhibition under abiotic stress conditions is one of the developmental and physiological strategies to acclimate to the changing environment.

  10. Outplacement and corporate social responsibility

    NARCIS (Netherlands)

    Jeurissen, R.J.M.


    This article presents a response to the following papers: "Ethical Marketing," by P.E. Murphy, G.R. Laczniak, N.E. Bowie, and T.A. Klein, "Marketing Ethics: Cases and Readings," edited by P.E. Murphy and G.R. Laczniak, "Advertising Ethics" by E.H. Spence and B. van Heekeren, and "Corporate Social

  11. Vibration response of misaligned rotors (United States)

    Patel, Tejas H.; Darpe, Ashish K.


    Misalignment is one of the common faults observed in rotors. Effect of misalignment on vibration response of coupled rotors is investigated in the present study. The coupled rotor system is modelled using Timoshenko beam elements with all six dof. An experimental approach is proposed for the first time for determination of magnitude and harmonic nature of the misalignment excitation. Misalignment effect at coupling location of rotor FE model is simulated using nodal force vector. The force vector is found using misalignment coupling stiffness matrix, derived from experimental data and applied misalignment between the two rotors. Steady-state vibration response is studied for sub-critical speeds. Effect of the types of misalignment (parallel and angular) on the vibration behaviour of the coupled rotor is examined. Along with lateral vibrations, axial and torsional vibrations are also investigated and nature of the vibration response is also examined. It has been found that the misalignment couples vibrations in bending, longitudinal and torsional modes. Some diagnostic features in the fast Fourier transform (FFT) of torsional and longitudinal response related to parallel and angular misalignment have been revealed. Full spectra and orbit plots are effectively used to reveal the unique nature of misalignment fault leading to reliable misalignment diagnostic information, not clearly brought out by earlier studies.

  12. Elementary School Philosophy: A Response (United States)

    Wartenberg, Thomas E.


    This article is a response to criticism of my book "Big Ideas for Little Kids." The main topics addressed are: Who is the audience for the book? Can people without formal philosophical training can be good facilitators of elementary school philosophy discussions? Is it important to assess attempts to teach philosophy in elementary school? Should…

  13. Public Relations: A Professional Responsibility (United States)

    Fox, Carol Lynne


    A public relations program for guidance services must be honest, continuous, positive, comprehensive, sensitive to the public's concern, and presented in nontechnical terms. A counselor has professional responsibility to convey his competencies and character of guidance services to the public through a public relations role. The school counselor…

  14. Responsible investing in South Africa

    NARCIS (Netherlands)

    Viviers, S.; Bosch, J.K.; Smit, vd M E.; Buijs, A.


    Given growing interest in the phenomenon of Responsible Investing (RI), both locally and internationally, the purpose of this paper is to provide an overview of the RI sector in South Africa. It focuses on the definition and characteristics of RI within the South African context; the size and nature

  15. Tensions of Corporate Social Responsibility

    DEFF Research Database (Denmark)

    Strand, Robert

    I engaged with the top management team (TMT) and employees of American Cafes Corporation as an action/intervention researcher in the 20 months immediately following the TMT’s decision to formalize the company’s corporate social responsibility (CSR) activities. This led to the establishment...

  16. Plant responses to multiple herbivory

    NARCIS (Netherlands)

    Li, Yehua


    This thesis explores whether aphid-infestation interferes with the plant response to chewing herbivores and whether this impacts performance and behaviour of individual chewing insect herbivores and their natural enemies, as well as the entire insect community. I investigated this using three wild

  17. Information Science and Responsive Evaluation (United States)

    Stake, Robert E.


    Responsive evaluation builds upon the methods of informal evaluation in disciplined ways: getting personally acquainted with the evaluand, observation of activities, interviewing people who are in different ways familiar with the evaluand, searching documents that reveal what happened in the past or somewhere else. It calls for sustained effort to…

  18. Parenting: Responsibilities, Risks and Respect (United States)

    Vincent, Carol


    Professor Carol Vincent gets the 2012 Professorial Lecture series underway with a thought provoking talk drawing on research projects conducted over the last twelve years. The lecture will explore factors identified in current policy, media, and other social and political forums as the risks and responsibilities of contemporary parenting, with a…

  19. Nonlocal Response in Plasmonic Nanostructures

    DEFF Research Database (Denmark)

    Wubs, Martijn; Mortensen, N. Asger


    After a brief overview of nanoplasmonics experiments that defy explanation with classical electrodynamics, we introduce nonlocal response as a main reason for non-classical effects. This concept is first introduced phenomenologically, and afterwards based on the semi-classical hydrodynamic Drude ...

  20. Green taxation and individual responsibility

    Energy Technology Data Exchange (ETDEWEB)

    Ballet, Jerome [C3ED Centre of Economics and Ethics for Environment and Development, UVSQ, University of Versailles, Saint-Quentin-en-Yvelines (France); Bazin, Damien [EMAFI Macroeconomics and International Finance Research Centre at University of Nice Sophia Antipolis, 28, avenue Valrose, BP 2135, 06103 Nice (France); Lioui, Abraham [Department of Economics, Bar Ilan University, Ramat Gan (Israel); Touahri, David [LEST Institute of Labor Econmics and Industrial Sociology and Mediterranean University Aix-Marseille II, Marseille (France)


    The current article aims at studying the effects of taxation on environmental quality, in an economy where its agents are responsible. Individual responsibility towards nature is modelized by the voluntary effort to which the households have agreed insofar as the improvement of environmental quality is concerned. It is an original way to show that the individuals may feel committed towards the environment and assume obligations towards it as well as towards environmental public policy. Given that, in our model, such effort is taken from one's allocated time for leisure, its opportunity cost is that of the sacrificed time for leisure, and is therefore equal to the individual's wage. We shall highlight that State intervention through the introduction of a (green) tax always crowds out individual responsibility. However, the intensity of this crowding-out depends on the performance of the State. Moreover, State intervention could, depending on the amount of crowding-out, reduce the overall quality of the environment. In a general equilibrium setting, we show that the crowding-out effect is not systematic. This is because there will then be an interaction between effort (or work time) and the cost of that effort (linked to the individual's wage, and therefore to production and finally to work/effort). In this article, we shall discuss the conditions under which public policy crowds out individual responsibility within this context. (author)

  1. Author's Response to Peer Commentary (United States)

    Hartley, James


    This article presents the author's response to peer commentary on his article entitled "Reflections on 50 years of teaching psychology." The author is pleased that most of them share some of his concerns about the lack of progress in the teaching of psychology over the last 50 years, and he welcomes the fact that they then go on to raise…

  2. Editorial. Sustainability: A social responsability


    Palmero Iglesias, Luis


    Editorial nº2_1 Palmero Iglesias, L. (2017). Editorial. Sustainability: A social responsability. VITRUVIO - International Journal of Architectural Technology and Sustainability. (1):vii-viii. doi:10.4995/vitruvio-ijats.2017.7650. vii viii 1 2

  3. Demand Response in Smart Grids

    DEFF Research Database (Denmark)

    Hansen, Jacob; Knudsen, Jesper Viese; Annaswamy, Anuradha M.


    In recent decades, moves toward higher integration of Renewable Energy Resources have called for fundamental changes in both the planning and operation of the overall power grid. One such change is the incorporation of Demand Response (DR), the process by which consumers can adjust their demand...

  4. Moral Responsibility and Computer Technology. (United States)

    Friedman, Batya

    Noting a recent increase in the number of cases of computer crime and computer piracy, this paper takes up the question, "How can understanding the social context of computing help us--as parents, educators, and members of government and industry--to educate young people to become morally responsible members of an electronic information…

  5. Speaking of Corporate Social Responsibility

    NARCIS (Netherlands)

    Liang, H.; Marquis, C.; Renneboog, L.D.R.; Li Sun, Sunny


    We argue that the language spoken by corporate decision makers influences their firms’ social responsibility and sustainability practices. Linguists suggest that obligatory future-time-reference (FTR) in a language reduces the psychological importance of the future. Prior research has shown that

  6. Corporate Social Responsibility for Sustainability

    Directory of Open Access Journals (Sweden)

    Wojciech Przychodzeń


    Full Text Available Purpose: The purpose of this paper is to is to provide insights on implementing corporate social responsibility for sustainability (CSRS concept and show how it differs from basic corporate social responsibility (CSR. Methodology: The paper discusses major issues with references to existing literature and real business cases from S&P500 consumer discretionary sector. Findings: The main fi nding of this paper is that CSRS could provide the company with a competitive advantage as a growing number of consumers become more sustainable conscious. It could also help to overcome the increasing consumers’ skepticism towards corporate social responsibility practices. Finally, it can also be seen as a step forward in defi ning what types of corporate activities are associated with desirable social and environmental gains. Research limitations: Our sample was restricted to the U.S. fi rms from the consumer discretionary sector. Therefore, conclusions should not be generalized to other markets. Our study is based on the analysis of environmental and social responsibility statements and assumes that they accurately represent corporate commitment in majority of the cases. Practical implications: CSRS offers corporations the opportunity to use their unique skills, culture, values, resources, and management capabilities to lead social progress by making sustainability part of its internal corporate logic. Originality: The paper raises the importance of the different conditions necessary for making sustainable development concept an important part of corporate strategy.

  7. Immune responses in space flight (United States)

    Sonnenfeld, G.


    Space flight has been shown to have profound effects on immunological parameters of humans, monkeys and rodents. These studies have been carried out by a number of different laboratories. Among the parameters affected are leukocyte blastogenesis, natural killer cell activity, leukocyte subset distribution, cytokine production - including interferons and interleukins, and macrophage maturation and activity. These changes start to occur only after a few days space flight, and some changes continue throughout long-term space flight. Antibody responses have received only very limited study, and total antibody levels have been shown to be increased after long-term space flight. Several factors could be involved in inducing these changes. These factors could include microgravity, lack of load-bearing, stress, acceleration forces, and radiation. The mechanism(s) for space flight-induced changes in immune responses remain(s) to be established. Certainly, there can be direct effects of microgravity, or other factors, on cells that play a fundamental role in immune responses. However, it is now clear that there are interactions between the immune system and other physiological systems that could play a major role. For example, changes occurring in calcium use in the musculoskeletal system induced by microgravity or lack of use could have great impact on the immune system. Most of the changes in immune responses have been observed using samples taken immediately after return from space flight. However, there have been two recent studies that have used in-flight testing. Delayed-type hypersensitivity responses to common recall antigens of astronauts and cosmonauts have been shown to be decreased when tested during space flights. Additionally, natural killer cell and blastogenic activities are inhibited in samples taken from rats during space flight. Therefore, it is now clear that events occurring during space flight itself can affect immune responses. The biological

  8. Hazardous Materials Management and Emergency Response (HAMMER) (United States)

    Federal Laboratory Consortium — The Volpentest Hazardous Materials Management and Emergency Response (HAMMER) Federal Training Center is a safety and emergency response training center that offers...

  9. Site-specific ground response analysis

    National Research Council Canada - National Science Library

    L. GovindaRaju; G. V. Ramana; C. HanumanthaRao; T. G. Sitharam


    ... modifications to the underlying motion. We highlight the engineering importance of site-specific ground response analysis and difficulties faced in conducting a complete ground response analysis...

  10. Copepod Response Behavior in Turbulence (United States)

    Krizan, Daniel

    The objective of this thesis is to determine copepod response to turbulence generated by obstacles in cross flow. Mainly, flow and copepod response downstream a square fractal grid is examined but experiments downstream a cylinder provides comparison. This is done by simultaneously measuring the copepods position and velocity using 3D-PTV in a measurement volume and measuring the two dimensional three component velocity vectors of the flow using stereo PIV. These measurements are done in a way that does not elicit copepod response. Tomographic PIV is done downstream the square fractal grid without copepods to gain volumetric velocity knowledge of the flow in the measurement volume. Copepods are known to execute sudden high speed jumps (or escapes) in response to sensed hydrodynamic signals. The fractal grid was shown to elicit copepod escape, specifically directly downstream with escape frequency decreasing further downstream where turbulence levels were much lower. It was found that at a slower freestream speed copepods exhibited jumps not in reaction to flow disturbances but to reorient themselves (cruise swimming). There was almost no copepod response in the wake of a cylinder, but copepods again exhibited cruise swimming behavior at a slower freestream speed. In regions with high maximum principal strain rate (MPSR) downstream of the fractal grid, copepods were observed to exhibit multiple escapes. Moreover, copepods were observed to jump towards regions of lower turbulence and against the freestream direction. From stereo PIV, instantaneous 2D MPSR values of less than 3s -1 were shown to create escape in 60% of copepod escapes analyzed. Finally, it was found that on average larger MPSR resulted in larger jumps from copepods.

  11. Responsibility and hand washing behaviour. (United States)

    Taylor, Jasmine; Purdon, Christine


    Recent research suggests that compulsions persist due to a self-perpetuating mechanism of poor memory confidence and repetition. However, most of this work has examined checking compulsions and findings may not generalize well to washing compulsions. This study examined the role of responsibility in the persistence of washing behaviour. Hand washing was examined in undergraduates (n = 80) high and low in contamination fears (CF) under conditions of high or low responsibility (RL). Wash duration and number of visits to objects/locations key to the wash (e.g., soap) were examined. Overvalued responsibility predicted washing duration across groups. Neither wash duration nor number of visits was associated with memory for the wash. Wash duration predicted post-wash certainty that the wash had prevented harm, but only in the high CF group, and that effect varied according to RL: longer wash duration predicted greater certainty under conditions of low RL but predicted less certainty under conditions of high RL. Greater repetition predicted poorer sensory confidence, but only in the high CF group under high RL conditions. The data were collected in an analogue sample of modest size. Replication in a clinical sample is required. Self-perpetuating mechanisms identified in perseverative checking seem to also be present in perseverative washing, but only under conditions of high responsibility. Sensory confidence may be more important to perseverative washing than memory confidence. More research is required to understand self-perpetuating mechanisms at play when washing to under conditions of high responsibility. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. NASA's Support to Flood Response (United States)

    Green, D. S.; Murray, J. J.; Stough, T.


    The extent of flood and inundation, the impacts on people and infrastructure, and generally the situational awareness on all scales for decision making are areas where NASA is mobilizing scientific results, advanced sensing and technologies, experts and partnerships to support response. NASA has targeted mature application science and ready technology for flood and inundation monitoring and assessment. This includes supporting timely data management and product dissemination with users and partners. Requirements are captured in the form of science-area questions, while solutions measure readiness for use by considering standard tools and approaches that make information more accessible, interoperable, understandable and reliable. The program collaborates with capacity building and areas of education and outreach needed to create and leverage non-traditional partnerships in transdisciplinary areas including socio-economic practice, preparedness and resilience assessment, early warning and forecast response, and emergency management, relief and recovery. The program outcomes also seek alignment with and support to global and community priorities related to water resources and food security. This presentation will examine the achievements of individual projects and the challenges and opportunities of more comprehensive and collaborative teams behind NASA's response to global flooding. Examples from recent event mobilization will be reviewed including to the serious of domestic floods across the south and Midwest United States throughout 2015 and 2016. Progress on the combined use of optical, microwave and SAR remote sensing measurements, topographic and geodetic data and mapping, data sharing practices will be reviewed. Other response case studies will examine global flood events monitored, characterized and supported in various boundary regions and nations. Achievements and future plans will be described for capabilities including global flood modeling, near real

  13. Modulating macrophage response to biomaterials (United States)

    Zaveri, Toral

    Macrophages recruited to the site of biomaterial implantation are the primary mediators of the chronic foreign body response to implanted materials. Since foreign body response limits performance and functional life of numerous implanted biomaterials/medical devices, various approaches have been investigated to modulate macrophage interactions with biomaterial surfaces to mitigate this response. In this work we have explored two independent approaches to modulate the macrophage inflammatory response to biomaterials. The first approach targets surface integrins, cell surface receptors that mediate cell adhesion to biomaterials through adhesive proteins spontaneously adsorbed on biomaterial surfaces. The second approach involves surface modification of biomaterials using nanotopographic features since nanotopography has been reported to modulate cell adhesion and viability in a cell type-dependent manner. More specifically, Zinc Oxide (ZnO) nanorod surface was investigated for its role in modulating macrophage adhesion and survival in vitro and foreign body response in vivo. For the first approach, we have investigated the role of integrin Mac-1 and RGD-binding integrins in the in-vivo osteolysis response and macrophage inflammatory processes of phagocytosis as well as inflammatory cytokine secretion in response to particulate biomaterials. We have also investigated the in vivo foreign body response (FBR) to subcutaneously implanted biomaterials by evaluating the thickness of fibrous capsule formed around the implants after 2 weeks of implantation. The role of Mac-1 integrin was isolated using a Mac-1 KO mouse and comparing it to a WT control. The role of RGD binding integrins in FBR was investigated by coating the implanted biomaterial with ELVAX(TM) polymer loaded with Echistatin which contains the RGD sequence. For the in-vivo osteolysis study and to study the in-vitro macrophage response to particulate biomaterials, we used the RGD peptide encapsulated in ELVAX

  14. Irrepressible, truncated Auxin Response Factors (United States)

    Ckurshumova, Wenzislava; Krogan, Naden T.; Marcos, Danielle; Caragea, Adriana E.; Berleth, Thomas


    The molecularly well-characterized auxin signal transduction pathway involves two evolutionarily conserved families interacting through their C-terminal domains III and IV: the Auxin Response Factors (ARFs) and their repressors the Aux/IAAs, to control auxin-responsive genes, among them genes involved in auxin transport.1,2 We have developed a new genetic tool to study ARF function. Using MONOPTEROS (MP)/ARF5, we have generated a truncated version of MP (MPΔ),3 which has lost the target domains for repression by Aux/IAA proteins. Besides exploring genetic interactions between MP and Aux/IAAs, we used this construct to trace MP’s role in vascular patterning, a previously characterized auxin dependent process.4,5 Here we summarize examples of naturally occurring truncated ARFs and summarize potential applications of truncated ARFs as analytical tools. PMID:22827953

  15. Responsible Canadian energy progress report

    Energy Technology Data Exchange (ETDEWEB)



    The Canadian Association of Petroleum Producers (CAPP) represents oil and gas companies throughout Canada; its members produce over 90% of Canada's natural gas and crude oil output. The aim of the Association is to improve the economics of the Canadian upstream petroleum sector in an environmentally and socially responsible way. The aim of this Responsible Canadian Energy report is to present the performance data of CAPP's members for the year 2009. Data, trends, and performance analyses are provided throughout the document. This analysis makes it possible to determine where progress has been made and where performance improvement is necessary. It also presents success stories and best practices so that other companies can learn from them how to improve their own performance. This paper provides useful information on the performance of the upstream petroleum industry in Canada and highlights where the focus should be for further improvement in its performance.

  16. Dynamical response of vibrating ferromagnets

    CERN Document Server

    Gaganidze, E; Ziese, M


    The resonance frequency of vibrating ferromagnetic reeds in a homogeneous magnetic field can be substantially modified by intrinsic and extrinsic field-related contributions. Searching for the physical reasons of the field-induced resonance frequency change and to study the influence of the spin glass state on it, we have measured the low-temperature magnetoelastic behavior and the dynamical response of vibrating amorphous and polycrystalline ferromagnetic ribbons. We show that the magnetoelastic properties depend strongly on the direction of the applied magnetic field. The influence of the re-entrant spin glass transition on these properties is discussed. We present clear experimental evidence that for applied fields perpendicular to the main area of the samples the behavior of ferromagnetic reeds is rather independent of the material composition and magnetic state, exhibiting a large decrease of the resonance frequency. This effect can be very well explained with a model based on the dynamical response of t...

  17. Crystallization Driven Responsive Janus Assembly (United States)

    Qi, Hao; Mei, Shan; Li, Christopher; Soft Materials Lab Team


    Responsive and dynamic nanostructures are ubiquitous in Nature, and they are also utter importance for applications such as sensing and drug delivery. Herein we report a series of hierarchical block copolymer nanostructure that is able to undergo 2D (sheet-like) to 3D (bowl-like) shape changing upon specific external stimuli. Freestanding Janus nanosheets were prepared via crystallization-driven self-assembly of poly(ɛ-caprolactone)-b-poly(acrylic acid) (PCL-b-PAA) and subsequent crosslinking and disassembly process. Due to the mechanical contrast between the two layers, and the chemical responsiveness of the PAA layer, such Janus nanosheets transform a mechanically stable nanobowl upon pH change. Atomic force microscopy and transmission electron microscopy results confirmed the Janus structure and bending behavior. Detailed structural characterization and shape changing mechanisms will be discussed.

  18. Responsible Investment: Taxes and Paradoxes

    Directory of Open Access Journals (Sweden)

    Knuutinen Reijo


    Full Text Available Taxes have become an issue of corporate social responsibility (CSR, but the role of taxation is to some extent an ambiguous and controversial issue in the CSR framework. Similarly, another unclear question is what role investors who are committed to sustainable and responsible investment (SRI see taxes as having on their environmental, social, and governance (ESG agenda. Corporate taxes have an inverse relationship with the return of the investors: taxes paid directly affect what is left on the bottom line, reducing the return of investors. However, investors are now more aware of tax-related risks, which can include different forms of reputation risk. Corporate tax planning may increase the returns, but those increased returns are riskier. This study focuses particularly on the relationship between SRI and taxation. We find that tax matters are considered to be on the ESG agenda, but their role and significance in the ESG analysis is unclear.

  19. Plant response to polluted air

    Energy Technology Data Exchange (ETDEWEB)

    Kendrick, J.B. Jr.; Darley, E.F.; Middleton, J.T.; Paulus, A.O.


    Field observations and controlled fumigation experiments have shown that plants differ in their response to atmospheric contamination by ethylene, herbicides, fluorides, sulfur dioxide, and smog, or oxidized hydrocarbons. Controlled experiments have also shown that plant response to air pollution varies with species and variety of plant, age of plant tissue, soil fertility levels, soil moisture, air temperatures during the prefumigation growth period, and presence of certain agricultural chemicals on leaves. The leaves of many plants; such as tomato, African marigold, fuchsia, pepper, and potato, become curved and malformed in the presence of ethylene, while those of cantaloupe, China aster, gardenia, Cattleya orchid, and snapdragon do not. Ethylene may cause serious damage to the sepals of orchids without injury to the petals or leaves.

  20. Thiamine– Responsive Megaloblastic Anemia Syndrome

    Directory of Open Access Journals (Sweden)

    F Motavaselian


    Full Text Available Thiamine Responsive megaloblastic anemia in DIDMOA (Wolfram syndrome has an autosomal- recessive mode of inheritance . Megaloblastic anemia and sideroblastic anemia is accompanied by diabetes insipidus (DI, diabetes mellitus (DM ,optic atrophy (OA and deafness (D. Neutropenia and thrombocytopenia are also present. We report a 7 month old girl with congenital macrocytic anemia; a rare clinical feature of Wolfram,s syndrome with increased plasma levels of blood glucose, both of which dramatically responded to administration of thiamine in large doses . The patient also had neurosensorial deafness, but no improvement was observed in the deafness. We presented the case because thiamine-responsive megaloblastic anemia is a rare clinical presentation of Wolfram syndrome and after institution of treatment with thiamine, the anemia and hyperglycemia returned to normal.

  1. Small Business Social Responsibility Communication

    DEFF Research Database (Denmark)

    Morsing, Mette; Spence, Laura J.


    Purpose: Corporate social responsibility communication by small and medium sized enterprises is theorized to form the concept of Small Business Social Responsibility (SBSR) Communication. Design/methodology/approach: This is a conceptual paper that draws on Foucault’s theory of governmentality...... to develop a theoretical explanation for SBSR communication. Findings: Our analysis conceptualizes the ‘governmentality dilemma’ as SBSR managers face two simultaneous and potentially counterproductive expectations: responding to externally prescribed expectations, norms and standards such as branding, codes...... of conduct and CSR reporting (i.e. CSR as a “regime of truth”, Foucault) and an internally prescribed ethos of a personal philosophy of ethics and norms such as family identity and employee values, concern for local community and legacy of the company (i.e. CSR as personally held values). We contribute...

  2. Anion-responsive supramolecular gels. (United States)

    Maeda, Hiromitsu


    Supramolecular gels that change their state or structure in response to anion stimuli have been highlighted. Only a few examples exist of such supramolecular gels, the structures and properties of which can be controlled and modulated by interactions with anions. To form anion-responsive dimensionally-controlled organized structures, the constituent low-molecular-weight gelator molecules must act as anion receptors by possessing one or more of van der Waals interaction units (aliphatic chains), stacking pi planes, hydrogen-bonding sites, and metal-coordination units. This Concept focuses on the gelation and transition behaviors of amide- and urea-based anion-stimulated systems, metal-coordinated systems, and novel acyclic pi-conjugated oligopyrroles that act as "molecular flippers."

  3. Beyond the basics: immune response. (United States)

    Krost, William S; Mistovich, Joseph J; Limmer, Daniel D


    The human immune response is arguably among the most difficult processes for an EMS provider to understand. The immune system provides front-line defense to any potentially inflammatory process, with the goal of destroying or inactivating pathogens, abnormal cells and foreign substances. The system includes the thymus, spleen, lymph nodes, lymphoid tissues (as in the GI tract and bone marrow), macrophages, lymphocytes, including B and T cells, and antibodies, among others. On the surface, the skin and stomach acid serve as physical barriers to invasion. This article will primarily concentrate on the immune response to allergies, but will discuss some other immune disorders to illustrate the role of the immune system in common disease processes.

  4. Voltage Controlled Dynamic Demand Response

    DEFF Research Database (Denmark)

    Bhattarai, Bishnu Prasad; Bak-Jensen, Birgitte; Mahat, Pukar


    central or dispersed generations might not be sufficient for future scenario. One of the effective methods to cope with this scenario is to enable demand response. This paper proposes a dynamic voltage regulation based demand response technique to be applied in low voltage (LV) distribution feeders....... An adaptive dynamic model has been developed to determine composite voltage dependency of an aggregated load on feeder level. Following the demand dispatch or control signal, optimum voltage setting at the LV substation is determined based on the voltage dependency of the load. Furthermore, a new technique...... has been proposed to estimate the voltage at consumer point of connection (POC) to ensure operation within voltage limits. Finally, the effectiveness of the proposed method is analyzed comprehensively with reference to three different scenarios on a low voltage (LV) feeder (Borup feeder) owned...

  5. Neurologic disorder and criminal responsibility. (United States)

    Yaffe, Gideon


    Sufferers from neurologic and psychiatric disorders are not uncommonly defendants in criminal trials. This chapter surveys a variety of different ways in which neurologic disorder bears on criminal responsibility. It discusses the way in which a neurologic disorder might bear on the questions of whether or not the defendant acted voluntarily; whether or not he or she was in the mental state that is required for guilt for the crime; and whether or not he or she is deserving of an insanity defense. The discussion demonstrates that a just determination of whether a sufferer from a neurologic disorder is diminished in his or her criminal responsibility for harmful conduct requires equal appreciation of the nature of the relevant disorder and its impact on behavior, on the one hand, and of the legal import of facts about the psychologic mechanisms through which behavior is generated, on the other. © 2013 Elsevier B.V. All rights reserved.

  6. Organizational responses to institutional contradictions

    DEFF Research Database (Denmark)

    Bjerregaard, Toke; Jonasson, Charlotte

    This paper examines the role of intraorganizational group and political processes in shaping the institutional forms that emerge in heterogeneous fields. We argue that while the specific institutional oppositions of heterogeneous fields compel organizational changes, the institutional forms....... Moreover, we argue that the boundary between practices in which organizational institutions change and are maintained are blurred. Hence, recruitment practices, which often are understood as carrying an institutional logic into an organization by being adopted in response to a new demand, may lead...... that emerge in such fields cannot easily be predicted. They are effects of indeterminate social processes of regularizations and breakings of co-existing logics. We illuminate the under-explored role of group strategies in moderating organizational response to conflicts in institutional prescriptions...

  7. Radiogenomics and radiotherapy response modeling (United States)

    El Naqa, Issam; Kerns, Sarah L.; Coates, James; Luo, Yi; Speers, Corey; West, Catharine M. L.; Rosenstein, Barry S.; Ten Haken, Randall K.


    Advances in patient-specific information and biotechnology have contributed to a new era of computational medicine. Radiogenomics has emerged as a new field that investigates the role of genetics in treatment response to radiation therapy. Radiation oncology is currently attempting to embrace these recent advances and add to its rich history by maintaining its prominent role as a quantitative leader in oncologic response modeling. Here, we provide an overview of radiogenomics starting with genotyping, data aggregation, and application of different modeling approaches based on modifying traditional radiobiological methods or application of advanced machine learning techniques. We highlight the current status and potential for this new field to reshape the landscape of outcome modeling in radiotherapy and drive future advances in computational oncology.



    Zafir Mohd Makhbul; Fazilah Mohamad Hasun


    Gender differences have been highlighted by the researchers in discussing the stress outcomes. Stress studies consistently show that females report significantly higher levels of psychological and physical stress than their male counterparts. The literature has shown that rarely have there been any studies conducted which are able to look at the gender responses to stress outcomes among supporting staff. The main objective of this paper is to compare the stress outcomes experienced by male an...

  9. Inflammatory response in equine joints


    Ley, Cecilia


    Proinflammatory cytokines mediate inflammatory responses as well as regulate tissue metabolism. Thus, they may provide a link between inflammation and other pathologic findings seen in equine joint disease. The aims of this thesis were to gain a deeper understanding of the development of chondral pathology in equine osteoarthritis (OA) by obtaining increased knowledge of inflammatory processes in the joint, and to investigate proinflammatory cytokines as markers of joint pathology. Measuremen...

  10. Egg introduction: differential allergic responses

    Directory of Open Access Journals (Sweden)

    Dosanjh A


    Full Text Available Amrita Dosanjh Medical Center, Rady Childrens Hospital, San Diego, CA, USA Abstract: The use of egg protein preparations in clinical trials to reduce the incidence of egg allergy among infants includes a number of preparations of egg. These include whole egg, egg white protein, and egg yolk preparations. The study of the differential immune responses to these allergenic proteins in comparison is suggested as a future research area of investigation. Keywords: food allergy, egg allergy, clinical trial, atopy

  11. The Dynamic Responsiveness of Organizations

    DEFF Research Database (Denmark)

    Andersen, Torben Juul

    Organizational studies should address contemporary challenges of dealing effectively with the increasingly complex and dynamic business conditions. In this context we argue that structural features are linked to the corporate strategy process and affect the organization’s ability to respond...... to ongoing environmental changes. Sustainable performance arguably derives from integrative strategy-making where business opportunities are pursued as they emerge while being directed and coordinated through forward-looking analytics. This combination of decentralized responsiveness and central reasoning...

  12. Dipolar response of hydrated proteins


    Matyushov, Dmitry V.


    The paper presents an analytical theory and numerical simulations of the dipolar response of hydrated proteins. The effective dielectric constant of the solvated protein, representing the average dipole moment induced at the protein by a uniform external field, shows a remarkable variation among the proteins studied by numerical simulations. It changes from 0.5 for ubiquitin to 640 for cytochrome c. The former value implies a negative dipolar susceptibility of ubiquitin, that is a dia-electri...

  13. Thiamine– Responsive Megaloblastic Anemia Syndrome


    F Motavaselian; F Nourani; Kh Dehghani; M Kheirandish; AH Jafari; A Hashemi


    Thiamine Responsive megaloblastic anemia in DIDMOA (Wolfram) syndrome has an autosomal- recessive mode of inheritance . Megaloblastic anemia and sideroblastic anemia is accompanied by diabetes insipidus (DI), diabetes mellitus (DM) ,optic atrophy (OA) and deafness (D). Neutropenia and thrombocytopenia are also present. We report a 7 month old girl with congenital macrocytic anemia; a rare clinical feature of Wolfram,s syndrome with increased plasma levels of blood glucose, both of which drama...

  14. Thermomechanical response of WIPP repositories

    Energy Technology Data Exchange (ETDEWEB)

    Maxwell, D.E.; Wahi, K.K.; Dial, B.


    Coarsely zoned STEALTH 2D calculations were used to investigate two candidate WIPP repositories. The grid was designed for one hundred thousand years of response with modest computing costs. As a result, the early time mechanical response was compromised by non-real oscillations that could not be damped completely before a few thousand years. In spite of these oscillations, it was possible to see that the dominant effects of stress and strain peaked between one and two thousand years, at the time of maximum heat in the site. This time corresponded to the condition that the surface heat loss rate balanced the heat generation rate. Though the creep strains were quite small, a large volume of salt was involved and the effects were significant. The peak surface uplift of 75HLW was increased by about 25% due to creep. However, the deviatoric stress relaxation due to creep produced large changes in the stress fields. The Rustler layer survived reasonable failure criterion for the 75HLW case with creep, and failed both in tension and shear, according to these same criterion, when the calculation was repeated without creep. The deviatoric stress fields, with and without salt creep, concentrated near the repository as expected and also in the Rustler layer due to its relatively high Young's modulus compared to the neighboring layers. Since the time of interest is so much smaller than the 100,000 years this calculation was designed to examine, it is possible to model the WIPP stratigraphy in much more detail and still be able to calculate the response for the time of interest. A finer zoned calculation of the response of the WIPP stratigraphy to a repository similar to the 75 K watt/acre repository is modeled in this report. In this calculation the Rustler formation is modeled as a five layered formation using material properties derived from data taken at the Nome site.

  15. Threat interferes with response inhibition. (United States)

    Hartikainen, Kaisa M; Siiskonen, Anna R; Ogawa, Keith H


    A potential threat, such as a spider, captures attention and engages executive functions to adjust ongoing behavior and avoid danger. We and many others have reported slowed responses to neutral targets in the context of emotional distractors. This behavioral slowing has been explained in the framework of attentional competition for limited resources with emotional stimuli prioritized. Alternatively, slowed performance could reflect the activation of avoidance/freezing-type motor behaviors associated with threat. Although the interaction of attention and emotion has been widely studied, little is known on the interaction between emotion and executive functions. We studied how threat-related stimuli (spiders) interact with executive performance and whether the interaction profile fits with a resource competition model or avoidance/freezing-type motor behaviors. Twenty-one young healthy individuals performed a Go-NoGo visual discrimination reaction time (RT) task engaging several executive functions with threat-related and emotionally neutral distractors. The threat-related distractors had no effect on the RT or the error rate in the Go trials. The NoGo error rate, reflecting failure in response inhibition, increased significantly because of threat-related distractors in contrast to neutral distractors, P less than 0.05. Thus, threat-related distractors temporarily impaired response inhibition. Threat-related distractors associated with increased commission errors and no effect on RT does not suggest engagement of avoidance/freezing-type motor behaviors. The results fit in the framework of the resource competition model. A potential threat calls for evaluation of affective significance as well as inhibition of undue emotional reactivity. We suggest that these functions tax executive resources and may render other executive functions, such as response inhibition, temporarily compromised when the demands for resources exceed availability.

  16. Overconfidence and Managers’ Responsibility Hoarding


    Nieken, Petra; Sadrieh, Abdolkarim; Zhou, Nannan


    Overconfidence is a well-established behavioral phenomenon that involves an overestimation of own capabilities. We introduce a model, in which managers and agents exert effort in a joint production, after the manager decides on the allocation of the tasks. A rational manager tends to delegate the critical task to the agent more often than given by the efficient task allocation. In contrast, an overconfident manager is more likely to hoard responsibility, i.e. to delegate the critical task les...


    Directory of Open Access Journals (Sweden)



    Full Text Available In the world today the need for improvement the business management quality assumes significant change in organization and mode of business management. Establishing of appropriate level, structure and authority of business management depends in most cases on the size, number of employees, complexness of technological and business process, market position and other factors. Development of a business requires decentralization of operative functions. The decentralization of a business means the increase of operative activities control of greater number of managers in such a business. An important segment that so far was neither sufficiently applied in the romanian practice, not sufficiently treated is a system of responsibility. One of the aims of this research is also stimulation of more intensive activities on initiating the process of accounting modernisation. First of all, on the improvement and more rational legal accounting regulation and motivation of professional accountants organization for quicker development of contemporary accounting principles and standards in compliance with tendencies of the european environment. The known experiences just point to the necessity of more complex perception of place and role of the management accounting and within it of the system of accounting responsibility in preparing of business plans and buget, in creation of development and investment policy. Therefore, the system of accounting responsibility should eneble monitoring and control of actual operational activities of each part of decentralized business. The process of performance evaluation and accounting responsibility in a descentralized business organization represents a significant element of an internal control system and in that sense the emphasis was put on that fact in this paper.

  18. Demand Response Spinning Reserve Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Eto, Joseph H.; Nelson-Hoffman, Janine; Torres, Carlos; Hirth,Scott; Yinger, Bob; Kueck, John; Kirby, Brendan; Bernier, Clark; Wright,Roger; Barat, A.; Watson, David S.


    The Demand Response Spinning Reserve project is a pioneeringdemonstration of how existing utility load-management assets can providean important electricity system reliability resource known as spinningreserve. Using aggregated demand-side resources to provide spinningreserve will give grid operators at the California Independent SystemOperator (CAISO) and Southern California Edison (SCE) a powerful, newtool to improve system reliability, prevent rolling blackouts, and lowersystem operating costs.

  19. Phenomenology between Pathos and Response

    Directory of Open Access Journals (Sweden)

    Bernhard Waldenfels


    Full Text Available The author calls phenomenological intentionality, into question while taking it, nevertheless, as a starting point. From the analysis of the meaning of phenomena he goes back to a pathic dimension which precedes them. What happens to us or affects us and to what we respond in different ways cannot be reduced to previous horizons. Between pathos and response, there is an irreducible cleft which constitutes a special sort of time-lag. What happens to us comes is always too early; our responses always come too late. Our experience is never completely up to date. In order to explore this pre-semantic and pre-pragmatic depth of experience we need a sort of responsive reduction, which guides all meaning toward something we respond to. In conclusion, the author evokes some areas in which such a revision of phenomenology shows its effects, namely the genesis of life in bioethics, the historical elaboration of memory and the experience of the Other.  

  20. Immune Responses in Hookworm Infections (United States)

    Loukas, Alex; Prociv, Paul


    Hookworms infect perhaps one-fifth of the entire human population, yet little is known about their interaction with our immune system. The two major species are Necator americanus, which is adapted to tropical conditions, and Ancylostoma duodenale, which predominates in more temperate zones. While having many common features, they also differ in several key aspects of their biology. Host immune responses are triggered by larval invasion of the skin, larval migration through the circulation and lungs, and worm establishment in the intestine, where adult worms feed on blood and mucosa while injecting various molecules that facilitate feeding and modulate host protective responses. Despite repeated exposure, protective immunity does not seem to develop in humans, so that infections occur in all age groups (depending on exposure patterns) and tend to be prolonged. Responses to both larval and adult worms have a characteristic T-helper type 2 profile, with activated mast cells in the gut mucosa, elevated levels of circulating immunoglobulin E, and eosinoophilia in the peripheral blood and local tissues, features also characteristic of type I hypersensitivity reactions. The longevity of adult hookworms is determined probably more by parasite genetics than by host immunity. However, many of the proteins released by the parasites seem to have immunomodulatory activity, presumably for self-protection. Advances in molecular biotechnology enable the identification and characterization of increasing numbers of these parasite molecules and should enhance our detailed understanding of the protective and pathogenetic mechanisms in hookworm infections. PMID:11585781

  1. Indentation responses of piezoelectric films (United States)

    Wang, J. H.; Chen, C. Q.; Lu, T. J.

    Frictionless indentation responses of transversely isotropic piezoelectric film/rigid substrate systems under circular cylindrical indenter (i.e., punch), conical indenter (i.e., cone), and spherical indenter (i.e., sphere) are investigated. Both insulating and conducting indenters are considered. The technique of Hankel transformation is employed to derive the corresponding dual integral equations for the mixed boundary value indentation problems. For the two limiting cases of infinitely thick and infinitely thin piezoelectric films, closed-form solutions are obtained. For piezoelectric films of finite thickness, a numerical method is constructed to solve the dual integral equations and semi-empirical models having only two unknown parameters are proposed for the responses of indentation force, electric charge and electric potential, and contact radius. With the two parameters inferred from the numerical results, the semi-empirical formulae are found to provide good estimates of the indentation responses for the two limiting cases of infinitely thick and thin piezoelectric films, as well as those in between. The inferred parameters in the proposed semi-empirical formulae for normalized indentation force and electric charge are checked against four different piezoelectric materials and are found to be insensitive to the selection of piezoelectric materials. It is believed that the proposed semi-empirical indentation formulae are useful in developing experimental indentation techniques to extract the material properties of piezoelectric films.

  2. Socially Responsible investment in Ukraine

    Directory of Open Access Journals (Sweden)

    Iryna Shkura


    Full Text Available Over the past 20 years the phenomenon of socially responsible investment (SRI has grown considerably in popularity and there has been in particular a sharp increase in research into its environmental, social and governance (ESG aspects. The process of SRI itself and research into this diverse phenomenon have become widespread particularly in developed countries and essentially supported by international organizations, specialized financial consulting companies, and institutional investors. The issues of theoretical, methodological and practical aspects of SRI in the Ukrainian market have considerable potential for research. The aim of the article is to study theoretical and methodological aspects of SRI as well as define the current state and prospects of socially responsible investment in Ukraine. The article covers the existing differences in the approaches to defining socially responsible investment and social investment, describes their features and proposes a method of classification, as well as clarifying the role of SRI under conditions of sustainable development. The current problems and prospects of SRI development in Ukraine are discussed.

  3. Responsibilities of Companies towards Employees

    Directory of Open Access Journals (Sweden)

    Monray Marsellus Botha


    Full Text Available Central to company law is the promotion of corporate governance. An important question in company law still today is in whose interest the company should be managed. Corporate governance needs to address the entire span of responsibilities to stakeholders of the company such as customers, employees, shareholders, suppliers and the community at large. The promotion of human rights in the application of company law must also take place. This is extremely important given the significant role of enterprises within the social and economic life of the nation. The interests of various stakeholder groups in the context of the corporation as a "social institution" should be enhanced and protected. Because corporations are part of society and the community, like all of us, it is required of them to be socially responsible and have greater accountability to all stakeholders of the company. Although directors must act in the best interests of shareholders collectively they must also consider the interests of other stakeholders. Sustainable relationships with all the relevant stakeholders are thus important. The advancement of social justice is thus important to corporations in that they should take note of the Constitution, labour legislation and company law legislation when social justice issues are dealt with. Employees have become very important stakeholders of companies and their needs should be taken into account in the bigger corporate governance and social responsibility framework.

  4. Reader-Response Theory and ELT. (United States)

    Hirvela, Alan


    Discusses the notion of personal response, which is a method in English-language teaching that aims to elicit learner production of discourse in the target language. The article distinguishes between reader-response and personal response approaches and demonstrates how the inclusion of reader response in literature-based communicative language…



    Petra F.A. Dilling


    As corporate social responsibility receives increased attention by company stakeholders, researchers are also increasingly exploring corporate social responsibility, its causes and implications. However little is known about the perception of corporate social responsibility. This study explores the link between stakeholder perception of corporate social responsibility and its relationship with underlying factors. The findings suggest that age of the corporation, community involvement, and cul...

  6. A Model of Academic Social Responsability

    Directory of Open Access Journals (Sweden)

    Alina Mihaela DIMA


    Full Text Available This paper develops the idea of academic social responsibility derived from the corporate social responsibility, presents the main achievements of the Romanian higher education system from the perspective of social responsibility and proposes a model of social responsibility in universities based on six dimensions determined by extensive literature review and content analysis.

  7. Response and Reinforcement in Operant Audiometry. (United States)

    Primus, Michael A.


    Response and reinforcement features of operant discrimination paradigms used in audiometric assessment were investigated with normal 17-month-old children. Findings indicated more responses prior to onset of habituation when response tasks involved complex central processing skills and a twofold increase in number of subject responses when…

  8. Parental Grief Response to Perinatal Death. (United States)

    Smith, Anne Clarke; Borgers, Sherry B.


    Examined grief responses of parents suffering perinatal loss and explored effects of gender, type of loss, time since loss, number of losses, and subsequent pregnancy on grief response. Responses to Grief Experience Inventory from 176 such parents revealed subjects suffering grief. Grief response was affected by subjects' perception that loss was…

  9. 32 CFR 700.802 - Responsibility. (United States)


    ... Officers in General § 700.802 Responsibility. (a) The responsibility of the commanding officer for his or... with his or her responsibility. While the commanding officer may, at his or her discretion, and when... responsibility for the safety, well-being, and efficiency of the entire command. (b) A commanding officer who...

  10. 30 CFR 780.4 - Responsibilities. (United States)


    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Responsibilities. 780.4 Section 780.4 Mineral... Responsibilities. (a) It is the responsibility of the applicant to provide to the regulatory authority all of the... responsibility of State and Federal governmental agencies to provide information to the regulatory authority...

  11. 30 CFR 740.4 - Responsibilities. (United States)


    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Responsibilities. 740.4 Section 740.4 Mineral... Responsibilities. (a) The Secretary is responsible for: (1) Approval, disapproval or conditional approval of mining... lands pursuant to the terms of any cooperative agreement. (c) The following responsibilities of OSM may...

  12. 32 CFR 327.3 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 327.3 Section 327.3 National... DEFENSE COMMISSARY AGENCY PRIVACY ACT PROGRAM § 327.3 Responsibilities. (a) The Director, DeCA. (1... requests received and prepares documentation to the office of primary responsibility (OPR) for response. (4...

  13. 30 CFR 783.4 - Responsibilities. (United States)


    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Responsibilities. 783.4 Section 783.4 Mineral... Responsibilities. (a) It is the responsibility of the applicant to provide, except where specifically exempted in this part, all information required by this part in the application. (b) It is the responsibility of...

  14. 30 CFR 779.4 - Responsibilities. (United States)


    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Responsibilities. 779.4 Section 779.4 Mineral... Responsibilities. (a) It is the responsibility of the applicant to provide, except where specifically exempted in this part, all information required by this part in the application. (b) It is the responsibility of...

  15. 32 CFR 290.6 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 290.6 Section 290.6 National... Responsibilities. (a) Headquarters. (1) The Assistant Director, Resources is responsible for: (i) The overall... Advisor, as required, in the discharge of their responsibilities. (iv) Coordinating Freedom of Information...

  16. 32 CFR 268.4 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 268.4 Section 268.4 National... COLLECTING AND REPORTING OF FOREIGN INDEBTEDNESS WITHIN THE DEPARTMENT OF DEFENSE § 268.4 Responsibilities..., or is otherwise assigned responsibility, is responsible for taking initial collection action...

  17. 30 CFR 784.4 - Responsibilities. (United States)


    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Responsibilities. 784.4 Section 784.4 Mineral... Responsibilities. (a) It is the responsibility of the applicant to provide to the regulatory authority all of the... responsibility of State and Federal governmental agencies to provide information to the regulatory authority...

  18. 15 CFR 14.41 - Recipient responsibilities. (United States)


    ... COMMERCIAL ORGANIZATIONS Post-Award Requirements Procurement Standards § 14.41 Recipient responsibilities... responsibilities arising under its contract(s). The recipient is the responsible authority, without recourse to the... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Recipient responsibilities. 14.41...

  19. Environment strategy: Issues and board responses


    Coulson-Thomas, Colin


    Examines and raises questions about issues facing boards in relation to environment strategy and their responses. Covers threats and opportunities, determining responses, monitoring developments, issues and responses, collective and collaborative responses, working and operating environments, making use of current and future infrastructure, impacts of new technologies on the environment, attitudes, perspectives, values and behaviours, reorienting corporate activities and creating new lifestyl...

  20. Disaster Response and Preparedness Application: Emergency Environmental Response Tool (EERT) (United States)

    Smoot, James; Carr, Hugh; Jester, Keith


    In 2000, the National Aeronautics and Space Administration (NASA) Environmental Office at the John C. Stennis Space Center (SSC) developed an Environmental Geographic Information Systems (EGIS) database. NASA had previously developed a GIS database at SSC to assist in the NASA Environmental Office's management of the Center. This GIS became the basis for the NASA-wide EGIS project, which was proposed after the applicability of the SSC database was demonstrated. Since its completion, the SSC EGIS has aided the Environmental Office with noise pollution modeling, land cover assessment, wetlands delineation, environmental hazards mapping, and critical habitat delineation for protected species. At SSC, facility management and safety officers are responsible for ensuring the physical security of the facilities, staff, and equipment as well as for responding to environmental emergencies, such as accidental releases of hazardous materials. All phases of emergency management (planning, mitigation, preparedness, and response) depend on data reliability and system interoperability from a variety of sources to determine the size and scope of the emergency operation. Because geospatial data are now available for all NASA facilities, it was suggested that this data could be incorporated into a computerized management information program to assist facility managers. The idea was that the information system could improve both the effectiveness and the efficiency of managing and controlling actions associated with disaster, homeland security, and other activities. It was decided to use SSC as a pilot site to demonstrate the efficacy of having a baseline, computerized management information system that ultimately was referred to as the Emergency Environmental Response Tool (EERT).

  1. Creating responsible partnerships in tourism

    Directory of Open Access Journals (Sweden)

    Ana Spitzer


    Full Text Available RQ: Organisations do not provide sufficient time and effort to seek out companies for partners that would, with the assistance of responsible cooperation, contribute to better quality offers and consequently to increased income and the good reputation of both companies. Responsibilities and ethics is where organizations on bothsides would take on and accept their own norms, tasks, obligations and be aware that in a relationship there is a need to give explanations and justify one’s actions, such partnerships will be long and prosperous. This requires a great deal of knowledge and maturity together with a very important personal characteristic that is care. This study examines whether the creation of long term partnerships through responsible and more personal (friendlyrelations brings the organization to greater success.Purpose: The purpose of this research is to determine how important it is for organizations in the tourism industry to build long term relationships, what it should be based on and whether companies are willing to change the current methods of operations.Method: The method of research was an interview with individuals that had a certain position within a tourism company and had contacts with partners and were obligated to see out new ones. A paradigm model was built and the responses analysed.Results: The survey results are encouraging. The interviews showed that respondents were aware that it is necessary to have long term and responsible partnerships. They recognized that in today’s world there is a lack of collaboration that is based on understanding andthat there should be more relations on a personal level. It isrequired that this changes in the future. The participants specifically highlight financial irresponsibility in many companies that destroys collaboration.Organization: With the help of this study, the author attempts to contribute ideas to organizations on how to create solid collaboration with partners, as

  2. Adhesion Characteristics and Swelling Response of Stimuli-Responsive Hydrogels (United States)

    Benjamin, Chandler

    Stimuli-responsive hydrogels are a class of shape memory materials that have been successfully used in microfluidic and biomedical devices and additionally as biomaterials. These materials operate in a hydrated environment and respond with a significant volumetric reversible transformation through absorption or release of water within the polymeric network. The pH sensitive 2-hydroxyethyl methacrylate (2-dimethylamino) ethyl methacrylate, (HEMA-DMAEMA) stimuli-responsive hydrogel is used in microfluidic devices as sensors and actuators. This hydrogel responds to an acidic aqueous environment with a subsequent volume change. This actuation requires the hydrogel to be in an acidic environment to remain in its swollen state. In chapter 2 I initially characterize this hydrogel in terms of engineering properties such as the storage modulus G', the loss modulus G'' and loss tangent tan(delta). The storage modulus is analogous to the shear modulus from elasticity theory. The loss modulus is a representation of energy dissipation from applied loading. The loss tangent tan(delta) is a measure of damping in a material. In chapter 3 I develop a method of measuring the Fung parameter beta° for stimuli-responsive hydrogels using a simple tensile test. HEMA-DMAEMA stimuli-responsive hydrogels are examined using this method. The HEMA-DMAEMA is pre-conditioned in 3.0 (acidic) pH and 11.0 (basic) pH buffer solutions prior to testing to compare the theoretical results to experiment in both the swollen and unswollen states. The measured Fung parameter beta° is 0.870 +/- 0.018. In chapter 4 I examine the interfacial adhesion of HEMA-DMAEMA. Experimental observations have given indications that the adhesion of the (HEMA-DMAEMA) is effected by substrate modifications. Using a unique experimental technique coupled with concepts from fracture mechanics I measure differences in the adhesive strength of HEMA-DMAEMA on borosilicate glass substrates, both unmodified and with different



    Ozan Büyükyılmaz; Yahya Fidan


    Corporate social responsibility includes the activities performed by enterprises that going beyond the legitimate expectations and carried out on a voluntary basis to improve the social and environmental well-being. In this study, the concept of corporate social responsibility is examined within the frame of definition and content, social responsibility theories, causes that enterprises are moving to social responsibility activities and the scope of social responsibility. It is intended to...

  4. Framework of Social Responsibilities of Forestry Enterprises


    SUI, Shuang; Zhang, Weimin


    Forestry industry plays a key role in regulating climate and promoting sustainable development of society. Environmental responsibility is the key part of social responsibilities of forestry enterprises. Based on the particularity of forestry industry, the framework of social responsibility reports of forestry enterprises is provided, and major topics of social responsibilities followed by forestry enterprises are analyzed. Meanwhile, the core values of social responsibilities of forestry ent...

  5. Rangeland plant response to elevated CO{sub 2}. Annual report, 1991

    Energy Technology Data Exchange (ETDEWEB)

    Owensby, C.E.; Coyne, P.I.; Ham, J.M.; Parton, W.; Rice, C.; Auen, L.M.; Adam, N.


    Effects of carbon dioxide enrichment on a tallgrass ecosystem were monitored during the 1990 growing season. The chambers, CO{sub 2} delivery system, and data acquisition and control system were in place and operational by 4 April 1990. CO{sub 2} fumigation and data acquisition began on that date. Nitrogen fertilizer as ammonium nitrate was applied at a rate of 45 kg ha {sup -1} on 1 April to the N-fertilized plots. The chambers were 4.5 m in diameter and 4 m in height to allow for destructive sampling for biomass accumulation, leaf area determination, and for grazing esophageally-fistulated sheep. The experimental site was located in pristine Tallgrass Prairie north of/and adjacent to the Kansas State University campus. Vegetation on the site was a mixture of C3 and C4 species and was dominated by big bluestem (Andropogon geradii vitman) and indiangrass (Sorghastrum nutans (L.) Nash). Subdominants included Kentucky bluegrass (Poa pratensis L.), sideoats grama (Bouteloua curtipendula (Michx.) Torr.), and tall dropseed (Sporobolus asper var. asper (Michx.) Kunth). Members of the sedge family made up 5-10% of the composition. Principal forbs included western ragweed (Ambrosia psilostachya DC.), Louisiana sagewort (Artemesia ludoviciana Nutt.), and mayflower scurfpea (Psoralea tenuiflora var. floribunda (Nutt.) Rydb.). Average peak biomass occurs in early August at 425 g m{sup -2} of which 35 g m{sup -2} is from forbs. The area was ideal for meeting the experimental objectives, in that the mixture of C3 and C4 plants would allow for assessment of competitive relationships among numerous species of both carbon fixation pathways.

  6. Host response in aggressive periodontitis. (United States)

    Kulkarni, Cyelee; Kinane, Denis F


    It is critical to understand the underlying host responses in aggressive periodontitis to provide a better appreciation of the risk and susceptibility to this disease. Such knowledge may elucidate the etiology and susceptibility to aggressive periodontitis and directly influence treatment decisions and aid diagnosis. This review is timely in that several widely held tenets are now considered unsupportable, namely the concept that Aggregatibacter actinomycetemycomitans is the key pathogen and that chemotactic defects in polymorphonuclear leukocytes are part of the etiopathology. This review also serves to put into context key elements of the host response that may be implicated in the genetic background of aggressive periodontitis. Furthermore, key molecules unique to the host response in aggressive periodontitis may have diagnostic utility and be used in chairside clinical activity tests or as population screening markers. It is becoming increasingly appreciated that the microbial etiology of aggressive periodontitis and the histopathology of this disease are more similar to than different from that of chronic periodontitis. An important therapeutic consideration from the lack of support for A. actinomycetemycomitans as a critical pathogen here is that the widely held belief that tetracycline had a role in aggressive periodontitis therapy is now not supported and that antibiotics such as those used effectively in chronic periodontitis (metronidazole and amoxicillin) are not contraindicated. Furthermore, A. actinomycetemycomitans-related molecules, such as cytolethal distending toxin and leukotoxin, are less likely to have utility as diagnosis agents or as therapeutic targets. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  7. Nested Dynamic Condition Response Graphs

    DEFF Research Database (Denmark)

    Hildebrandt, Thomas; Mukkamala, Raghava Rao; Slaats, Tijs


    We present an extension of the recently introduced declarative process model Dynamic Condition Response Graphs ( DCR Graphs) to allow nested subgraphs and a new milestone relation between events. The extension was developed during a case study carried out jointly with our industrial partner...... Exformatics, a danish provider of case and workflow management systems. We formalize the semantics by giving first a map from Nested to (flat) DCR Graphs with milestones, and then extending the previously given mapping from DCR Graphs to Buchi-automata to include the milestone relation....

  8. Climate Responsive Buildings in China

    DEFF Research Database (Denmark)

    Haase, M.; Amato, A.; Heiselberg, Per


    energy strategies to develop guidelines and procedures for estimation of environmental performance of responsive building elements and integrated building concepts This paper introduces the ideas of this collaborative work within the framework of the Annex44 of the International Energy Agency (IEA......) and discusses its usefulness for Hong Kong and China. Special focus was put on the description of the different climates in China and a detailed analysis revealed its potential for energy conservation strategies. It could be shown that Natural Ventilation (NV) has the potential to increase thermal comfort up...

  9. Communication, Marketing and Corporate Responsibility

    Directory of Open Access Journals (Sweden)

    Frederico de Andrade Gabrich


    Full Text Available Advertising, which stems from the strategic planning of the company's marketing , integrates the proposal and the corresponding consumer contract to the product or service offered to the market. As part of the contract, advertising and communication strategies and business marketing also undergo fully the principle of information and the principle of good faith in its objective meaning. Therefore, communication strategies, marketing planning and advertising actions of truly citizen and responsible company should be structured legally in order to consider all related duties in good faith.

  10. Dipolar response of hydrated proteins. (United States)

    Matyushov, Dmitry V


    The paper presents an analytical theory and numerical simulations of the dipolar response of hydrated proteins in solution. We calculate the effective dielectric constant representing the average dipole moment induced at the protein by a uniform external field. The dielectric constant shows a remarkable variation among the proteins, changing from 0.5 for ubiquitin to 640 for cytochrome c. The former value implies a negative dipolar susceptibility, that is a dia-electric dipolar response and negative dielectrophoresis. It means that ubiquitin, carrying an average dipole of ≃240 D, is expected to repel from the region of a stronger electric field. This outcome is the result of a negative cross-correlation between the protein and water dipoles, compensating for the positive variance of the intrinsic protein dipole in the overall dipolar susceptibility. In contrast to the neutral ubiquitin, charged proteins studied here show para-electric dipolar response and positive dielectrophoresis. The study suggests that the dipolar response of proteins in solution is strongly affected by the coupling of the protein surface charge to the hydration water. The protein-water dipolar cross-correlations are long-ranged, extending ~2 nm from the protein surface into the bulk. A similar correlation length of about 1 nm is seen for the electrostatic potential produced by the hydration water inside the protein. The analysis of numerical simulations suggests that the polarization of the protein-water interface is highly heterogeneous and does not follow the standard dielectric results for cavities carved in dielectrics. The polarization of the water shell gains in importance, relative to the intrinsic protein dipole, at high frequencies, above the protein Debye peak. The induced interfacial dipole can be either parallel or antiparallel to the protein dipole, depending on the distribution of the protein surface charge. As a result, the high-frequency absorption of the protein solution can

  11. Environmental philosophy: response to critics. (United States)

    Sarkar, Sahotra


    The following piece is a response to the critiques from Frank, Garson, and Odenbaugh. The issues at stake are: the definition of biodiversity and its normativity, historical fidelity in ecological restoration, naturalism in environmental ethics, and the role of decision theory. The normativity of the concept of biodiversity in conservation biology is defended. Historical fidelity is criticized as an operative goal for ecological restoration. It is pointed out that the analysis requires only minimal assumptions about ethics. Decision theory is presented as a tool, not a domain-limiting necessary requirement for environmental philosophy. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. Combating plagiarism: a shared responsibility. (United States)

    Rathod, Sujit D


    Scientific progress depends on the free dissemination of original thinking and research. With the evidence base formed by publication, investigators develop and implement additional studies, and policy makers propose new laws and regulations. The ramifications of this evidence can affect millions of lives and reallocate considerable resources for programmes or research. As such, it is incumbent on investigators to conduct rigorous research, which precludes engaging in scientific misconduct such as falsification, fabrication and plagiarism. This article addresses the causes and consequences of plagiarism and the processes by which plagiarism is discovered. It concludes by considering the responsibilities of members of the research community in preventing and addressing plagiarism.


    Directory of Open Access Journals (Sweden)



    Full Text Available In this article the authors aim to create a presentation of the triangle morals-ethics-responsibility with an accent on the current globalized society. Business ethics has to disseminate in all the corners of a company, and first of all it has to be understood. Understanding the moral criteria of behaviour in business is important because the new Organizational structures create new complications, related to information flow and information administration inside various workgroups and in the entire organization, for which there are no traditional precedents.

  14. Protein causes a glycemic response. (United States)

    Whelan, William J; Ghanchi, Hammad; Ricciardi, Michael


    The glycemic index is used to compare the extent to which the blood glucose level increases following the consumption of foods containing digestible carbohydrate and is considered to be zero, or not measurable, if the food, such as protein, is carbohydrate-free. We have found that after overnight fasting, the consumption of several varieties of meat caused significant increases in blood glucose levels. We consider these possibly to be because of gluconeogenesis from the digested protein. It is a curious feature that in two instances the response was inversely related to the amount of meat consumed, over the range from 26 to 78 g of protein.

  15. Seismic response of linear accelerators

    CERN Document Server

    Collette, C; Guinchard, M; Hauviller, C


    This paper is divided into two parts. The first part presents recent measurements of ground motion in the LHC tunnel at CERN. From these measurements, an update of the ground motion model currently used in accelerator simulations is presented. It contains new features like a model of the lateral motion and the technical noise. In the second part, it is shown how this model can be used to evaluate the seismic response of a linear accelerator in the frequency domain. Then, the approach is validated numerically on a regular lattice, taking the dynamic behavior of the machine alignment stage and the mechanical stabilization of the quadrupoles into account.

  16. Seismic response of linear accelerators

    Directory of Open Access Journals (Sweden)

    C. Collette


    Full Text Available This paper is divided into two parts. The first part presents recent measurements of ground motion in the LHC tunnel at CERN. From these measurements, an update of the ground motion model currently used in accelerator simulations is presented. It contains new features like a model of the lateral motion and the technical noise. In the second part, it is shown how this model can be used to evaluate the seismic response of a linear accelerator in the frequency domain. Then, the approach is validated numerically on a regular lattice, taking the dynamic behavior of the machine alignment stage and the mechanical stabilization of the quadrupoles into account.

  17. Coastal hypoxia responses to remediation (United States)

    Kemp, W. M.; Testa, J. M.; Conley, D. J.; Gilbert, D.; Hagy, J. D.


    The incidence and intensity of hypoxic waters in coastal aquatic ecosystems has been expanding in recent decades coincident with eutrophication of the coastal zone. Because of the negative effects hypoxia has on many organisms, extensive efforts have been made to reduce the size and duration of hypoxia in many coastal waters. Although it has been broadly assumed that reductions in nutrient loading rates would reverse eutrophication and consequently, hypoxia, recent analyses of historical data from European and North American coastal systems suggest little evidence for simple linear response trajectories. We review existing data, analyses, and models that relate variations in the extent and intensity of hypoxia to changes in loading rates for inorganic nutrients and labile organic matter. We also assess existing knowledge of physical and ecological factors regulating oxygen in coastal marine waters and examine a broad range of examples where hypoxia responses to reductions in nutrient (or organic matter) inputs have been documented. Of the 22 systems identified where concurrent time series of loading and O2 were available, half displayed relatively clear and direct recoveries following remediation. We explored in detail 5 well-studied systems that have exhibited complex, non-linear responses to loading, including apparent "regime shifts." A summary of these analyses suggests that O2 conditions improved rapidly and linearly in systems where remediation focused on organic inputs from sewage plants, which were the primary drivers of hypoxia. In larger more open systems where diffuse nutrient loads are more important in fueling O2 depletion and where climatic influences are pronounced, responses to remediation tend to follow non-linear trends that may include hysteresis and time-lags. Improved understanding of hypoxia remediation requires that future studies use comparative approaches and consider multiple regulating factors including: (1) the dominant temporal scales

  18. Subject Responses to Electrochromic Windows

    Energy Technology Data Exchange (ETDEWEB)

    Clear, Robert; Inkarojrit, Vorapat; Lee, Eleanor


    Forty-three subjects worked in a private office with switchable electrochromic windows, manually-operated Venetian blinds, and dimmable fluorescent lights. The electrochromic window had a visible transmittance range of approximately 3-60%. Analysis of subject responses and physical data collected during the work sessions showed that the electrochromic windows reduced the incidence of glare compared to working under a fixed transmittance (60%) condition. Subjects used the Venetian blinds less often and preferred the variable transmittance condition, but used slightly more electric lighting with it than they did when window transmittance was fixed.

  19. Social Representations of Responsibility in Guatemalan Students

    Directory of Open Access Journals (Sweden)

    Humberto Emilio Aguilera Arévalo


    Full Text Available The responsibility is a key concept in the twentieth century because it establishes a connection between the individual and society. Recent studies analyze the responsibility as a relational concept that connects the individual to an event and its outcomes. In that sense, the responsibility may be linked to Markova perspective on dialogicality and social representations because it activates the Ego-Alter-Object dynamic: being responsible for something (Ego toward someone (Alter, and in relation to an instance (object. This paper analyzes the social representations of responsibility in a sample of 296 university students from Guatemala, who answered six stimulus words I Responsible, I Irresponsible, Responsible Guatemalan, Irresponsible Guatemalan, Responsible European and Irresponsible European, using the natural semantic networks technique. Subsequently two questionnaires were made; one about responsibility and irresponsibility on a personal, in group and out group level, based on semantic networks obtained. Finally, factor analysis and hierarchical cluster analysis were made.

  20. Noninvasive imaging of immune responses. (United States)

    Rashidian, Mohammad; Keliher, Edmund J; Bilate, Angelina M; Duarte, Joao N; Wojtkiewicz, Gregory R; Jacobsen, Johanne Tracey; Cragnolini, Juanjo; Swee, Lee Kim; Victora, Gabriel D; Weissleder, Ralph; Ploegh, Hidde L


    At their margins, tumors often contain neutrophils, dendritic cells, and activated macrophages, which express class II MHC and CD11b products. The interplay between stromal cells, tumor cells, and migratory cells such as lymphocytes creates opportunities for noninvasive imaging of immune responses. We developed alpaca-derived antibody fragments specific for mouse class II MHC and CD11b products, expressed on the surface of a variety of myeloid cells. We validated these reagents by flow cytometry and two-photon microscopy to obtain images at cellular resolution. To enable noninvasive imaging of the targeted cell populations, we developed a method to site-specifically label VHHs [the variable domain (VH) of a camelid heavy-chain only antibody] with (18)F or (64)Cu. Radiolabeled VHHs rapidly cleared the circulation (t1/2 ≈ 20 min) and clearly visualized lymphoid organs. We used VHHs to explore the possibility of imaging inflammation in both xenogeneic and syngeneic tumor models, which resulted in detection of tumors with remarkable specificity. We also imaged the infiltration of myeloid cells upon injection of complete Freund's adjuvant. Both anti-class II MHC and anti-CD11b VHHs detected inflammation with excellent specificity. Given the ease of manufacture and labeling of VHHs, we believe that this method could transform the manner in which antitumor responses and/or infectious events may be tracked.

  1. Static response of deformable microchannels (United States)

    Christov, Ivan C.; Sidhore, Tanmay C.


    Microfluidic channels manufactured from PDMS are a key component of lab-on-a-chip devices. Experimentally, rectangular microchannels are found to deform into a non-rectangular cross-section due to fluid-structure interactions. Deformation affects the flow profile, which results in a nonlinear relationship between the volumetric flow rate and the pressure drop. We develop a framework, within the lubrication approximation (l >> w >> h), to self-consistently derive flow rate-pressure drop relations. Emphasis is placed on handling different types of elastic response: from pure plate-bending, to half-space deformation, to membrane stretching. The ``simplest'' model (Stokes flow in a 3D rectangular channel capped with a linearly elastic Kirchhoff-Love plate) agrees well with recent experiments. We also simulate the static response of such microfluidic channels under laminar flow conditions using ANSYSWorkbench. Simulations are calibrated using experimental flow rate-pressure drop data from the literature. The simulations provide highly resolved deformation profiles, which are difficult to measure experimentally. By comparing simulations, experiments and our theoretical models, we show good agreement in many flow/deformation regimes, without any fitting parameters.

  2. Responsive Polymers for Crop Protection

    Directory of Open Access Journals (Sweden)

    Serban F. Peteu


    Full Text Available This review outlines the responsive polymer methods currently in use with their potential application to plant protection and puts forward plant-specific mechanisms as stimuli in newly devised methods for smart release of crop protection agents (CPAs. CPAs include chemicals (fungicides, insecticides, herbicides, biochemicals (antibiotics, RNA-based vaccines for plant viruses, semiochemicals (pheromones, repellents, allomones, microbial pesticides, growth regulators (insect and plant or micronutrients, all with crop protection effects. This appraisal focuses on emerging uses of polymer nano-encapsulated CPAs. Firstly, the most interesting advances in controlled release methods are critically discussed with their advantages and drawbacks. Secondly, several plant-specific stimuli-based smart methods are anticipated for use alongside the polymer nano- or micro-capsules. These new CPA release methods are designed to (i protect plants against infection produced by fungi or bacteria, and (ii apply micro-nutrients when the plants need it the most. Thus, we foresee (i the responsive release of nano- encapsulated bio-insecticides regulated by plant stress enzymes, and (ii the delivery of micro-nutrients synchronized by the nature or intensity of plant root exudates. Such continued advances of nano-scale smart polymer-based CPAs for the protection of crops herald a “small revolution” for the benefit of sustainable agriculture.

  3. Return to joint parental responsibility. (United States)

    Pierotti, D


    Along the frontiers of the former Soviet Union young women die every day because of the serious medical conditions preventing childbearing; they die because they are culturally obligated to reproduce. Such cultural codes led to the death of a 15-year-old girl who was killed by her immigrant father and other relatives because she wanted to live like her peers in the French city of Colmar. A 1992 visit of the author to Catalonia to discuss male reproductive roles made him reevaluate earlier views. Traditional sexist attitudes resulted in the expulsion of pregnant students from a nursing school by a male doctor who blamed them, while male partners were acquitted. Preparation for the conference in Barcelona by reviewing 20 years of work on male sexuality and family planning yielded only a few studies on male responsibility and the changing role of males. The advent of modern contraceptives has weakened male supremacy in Europe except among some immigrant families and religious extremists. Divorce and child custody laws, favoring the mother further, eroded male dominance. Even organizations have been formed to defend male rights. In vitro fertilization was endorsed by American lesbians in an article in 1993 reducing males to sperm donor status. Modern reproductive medical technology seems to have broken all limits; even elderly women can be made to conceive. These extreme examples indicate that the male-female relationships and joint responsibility for raising children in a family should be resuscitated based on equal terms for emotional stability and benefit of parents and progeny.

  4. Physicians' responses to resource constraints. (United States)

    Hurst, Samia A; Hull, Sara Chandros; DuVal, Gordon; Danis, Marion


    A common dilemma that confronts physicians in clinical practice is the allocation of scarce resources. Yet the strategies used by physicians in actual situations of resource constraint have not been studied. This study explores the strategies and rationales reported by physicians in situations of resource constraints encountered in practice. A national survey of US internists, oncologists, and intensive care specialists was performed by computer-assisted telephone interviews. As part of this survey, we asked physicians to tell us about a recent ethical dilemma encountered in practice. A subset of respondents reported difficulties regarding resource allocation. Transcripts of open-ended responses were coded for content based on consensus. Of the 600 physicians originally identified, 537 were eligible and 344 participated (response rate, 64%). Internists do not make allocation decisions alone but rather engage in negotiation in their resolution. Furthermore, these decisions are not made as dichotomous choices. Rather they often involve alternative solutions in the face of complexities of both the health care system and situations where limited resources must be allocated. Justice is not commonly the justification for rationing. Physicians' experiences in situations of resource constraints appear to be more complex than the normative literature on health care rationing assumes. In addition, reasoning about justice in health care seems to play only a small part in clinical decision making. Bridging this gap could be an important step in fostering fair allocation of resources in difficult cases.

  5. Otto Hahn achievement and responsibility

    CERN Document Server

    Hoffmann, Klaus


    Otto Hahn (1879-1968) was awarded the 1944 Nobel Prize for Chemistry for his work on atomic fission: his work in Berlin in the 1930s and 1940s with Lise Meitner and Fritz Strassmann led to the discovery that uranium nuclei bombarded by neutrons undergo spontaneous fission, releasing enormous energies. This work, conveyed to England and the US by scientific refugees from Nazi Germany, led to the instigation of the Manhattan Project and the development of the Atomic Bomb. Reviled by many after the war as one of the people responsible for the carnage at Hiroshima and Nagasaki, Hahn had already begun to reflect on the social responsibility of scientists for their fundamental discoveries and the subsequent applications of the knowledge they create. Already during the war, Hahn had protested Nazi restrictions on Universities and researchers, and after the War, he became actively involved in efforts to restrict the spread of nuclear weapons. In this volume Klaus Hoffmann discusses Hahn's contributions to science and...

  6. Ombuds’ corner: responsibility and reporting

    CERN Multimedia

    Vincent Vuillemin


    In this series, the Bulletin aims to explain the role of the Ombuds at CERN by presenting practical examples of misunderstandings that could have been resolved by the Ombuds if he had been contacted earlier. Please note that, in all the situations we present, the names are fictitious and used only to improve clarity.   Jack* is a new staff member. He joined CERN after having worked successfully in industry, where he had been given considerable responsibility in projects as well as in human resources, despite the fact that he was still young. After a few months, given his expertise, he found himself in charge of part of a project, technically, and also responsible for a few collaborators. That did not present any difficulty for him given his past experience where he was used to handling business in quite an independent way. Also, a high level of respect and ethics had been encouraged by his past employer, which helped him in the interaction with his colleagues. For some tim...

  7. Synthetic biology, metaphors and responsibility. (United States)

    McLeod, Carmen; Nerlich, Brigitte


    Metaphors are not just decorative rhetorical devices that make speech pretty. They are fundamental tools for thinking about the world and acting on the world. The language we use to make a better world matters; words matter; metaphors matter. Words have consequences - ethical, social and legal ones, as well as political and economic ones. They need to be used 'responsibly'. They also need to be studied carefully - this is what we want to do through this editorial and the related thematic collection. In the context of synthetic biology, natural and social scientists have become increasingly interested in metaphors, a wave of interest that we want to exploit and amplify. We want to build on emerging articles and books on synthetic biology, metaphors of life and the ethical and moral implications of such metaphors. This editorial provides a brief introduction to synthetic biology and responsible innovation, as well as a comprehensive review of literature on the social, cultural and ethical impacts of metaphor use in genomics and synthetic biology. Our aim is to stimulate an interdisciplinary and international discussion on the impact that metaphors can have on science, policy and publics in the context of synthetic biology.

  8. Towards a more responsible press

    Directory of Open Access Journals (Sweden)

    Taimur ul Hassan


    Full Text Available The article analyses Pakistan’s newspapers’ performance with regard to civil society in2003 by using content analysis approach. There is no gainsaying that a strong civil society guaranteesa strong democracy. In Pakistan, spells of military rule have stunted the growth of democracy,adversely affecting civil society. Media too has suffered as a result. Normative theories of media callfor laying down norms and conventions for media. In democracy, all sections of society should berepresented in media. In Pakistan’s case, due to military regimes and quasi democratic governments,combined with the demands of market economy, the media have largely not been able to fulfill thisresponsibility towards society. Social Responsibility demands that the media must fulfill itsresponsibility towards society, while giving a free space to all voices of society. In Pakistan, whethernewspapers played that role in 2003 when civil society had accelerated its campaign to end honorkillings and crimes against women is investigated. The findings show that newspapers did supportcivil society, showing a gradual movement towards a more responsible press.

  9. Inflammatory Response in Islet Transplantation

    Directory of Open Access Journals (Sweden)

    Mazhar A. Kanak


    Full Text Available Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle type 1 diabetes as well as refractory chronic pancreatitis. Despite the vast advancements made in this field, challenges still remain in achieving high frequency and long-term successful transplant outcomes. Here we review recent advances in understanding the role of inflammation in islet transplantation and development of strategies to prevent damage to islets from inflammation. The inflammatory response associated with islets has been recognized as the primary cause of early damage to islets and graft loss after transplantation. Details on cell signaling pathways in islets triggered by cytokines and harmful inflammatory events during pancreas procurement, pancreas preservation, islet isolation, and islet infusion are presented. Robust control of pre- and peritransplant islet inflammation could improve posttransplant islet survival and in turn enhance the benefits of islet cell transplantation for patients who are insulin dependent. We discuss several potent anti-inflammatory strategies that show promise for improving islet engraftment. Further understanding of molecular mechanisms involved in the inflammatory response will provide the basis for developing potent therapeutic strategies for enhancing the quality and success of islet transplantation.

  10. Adaptive Planning For Threat Response (United States)

    Hayslip, Iris C.; Rosenking, Jeffrey P.


    In this paper we present a design for a multilevel planning system which addresses some of the real time aspects of planning for threat response. Our approach utilizes multiple knowledge representations, and a coupled system of AI and conventional models. The motivation behind this design is to maximize the amount and depth of knowledge which can be utilized depending upon the amount of time which is available to plan. This research is part of the continued development of Grumman's Rapid Expert Assessment to Counter Threats (REACT) system; designed to aid pilots in air combat decision making. REACT consists of cooperating expert systems which communicate and are controlled by the use of a blackboard architecture. This paper concentrates on the REACT module which deals with fast response planning for combat maneuvering at low altitude over hilly terrain. REACT research has led to many interesting and potentially useful results applicable to general autonomous vehicle control architectures. In particular work on integrating the capability in REACT to reason about the tactical use of terrain has suggested guidelines for knowledge base design and data management, system and language specifications, and planner architectures pertinent to real-time coupled systems. We also describe the associated implementation progress, where the experimental planner is being integrated into the multi-language modular system.

  11. Responsible marketing for sustainable tourism

    Directory of Open Access Journals (Sweden)

    Jegdić Vaso


    Full Text Available The biggest challenge associated with the concept of sustainable tourism is its operationalisation and perception as a process to be applied through development plans, projects and ongoing activities of tour operators. The traditional approach to marketing, focused on a limited idea of maximising profit businesses, was not able to respond to a number of social and environmental requirements imposed by the concept of sustainable development. This paper discusses the ways in which marketing could play a more important role in the sustainable development of tourism. This refers to the determination of consumer needs and preferences, the formation of certain products and pricing, product information and advertising to consumers of their benefits in a sustainable manner, as well as adequate distribution channels used by businesses to deliver products to consumers. Environmental and social marketing are now being confirmed as important elements of a much broader marketing perspective. In order to develop tourism with sustainable outcomes, responsible marketing can be crucial. The concept of marketing mix for sustainable tourism was used as a starting point to explore the specific role of responsible marketing in tourism.

  12. Comparing bee species responses to chemical mixtures: Common response patterns?

    Directory of Open Access Journals (Sweden)

    Alex Robinson

    Full Text Available Pollinators in agricultural landscapes can be exposed to mixtures of pesticides and environmental pollutants. Existing mixture toxicity modelling approaches, such as the models of concentration addition and independent action and the mechanistic DEBtox framework have been previously shown as valuable tools for understanding and ultimately predicting joint toxicity. Here we apply these mixture models to investigate the potential to interpret the effects of semi-chronic binary mixture exposure for three bee species: Apis mellifera, Bombus terrestris and Osmia bicornis within potentiation and mixture toxicity experiments. In the potentiation studies, the effect of the insecticide dimethoate with added propiconazole fungicide and neonicotinoid insecticide clothianidin with added tau-fluvalinate pyrethroid acaricide showed no difference in toxicity compared to the single chemical alone. Clothianidin toxicity showed a small scale, but temporally conserved increase in exposure conducted in the presence of propiconazole, particularly for B. terrestris and O. bicornis, the latter showing a near three-fold increase in clothianidin toxicity in the presence of propiconazole. In the mixture toxicity studies, the dominant response patterns were of additivity, however, binary mixtures of clothianidin and dimethoate in A. mellifera, B. terrestris and male O. bicornis there was evidence of a predominant antagonistic interaction. Given the ubiquitous nature of exposures to multiple chemicals, there is an urgent need to consider mixture effects in pollinator risk assessments. Our analyses suggest that current models, particularly those that utilise time-series data, such as DEBtox, can be used to identify additivity as the dominant response pattern and also those examples of interactions, even when small-scale, that may need to be taken into account during risk assessment.

  13. Corporate Social Responsibility: Why? ethical justification of corporate social responsibility

    Directory of Open Access Journals (Sweden)

    Susy Caballero Jara


    Full Text Available Mucho se ha discutido en el Perú sobre qué es la responsabilidad social empresarial (RSE ycómo se implementa. La pregunta de por qué, en cambio, no ha recibido similar interés. Esta esprecisamente la interrogante que el presente artículo busca responder: ¿Qué justifica la RSE?¿Por qué las empresas deben ser socialmente responsables?Tomando como punto de partida la clasificación en cuatro grandes teorías de responsabilidadsocial empresarial o corporativa propuesta por Garriga y Melé (2004, a saber, las teoríasinstrumentales, políticas, integradoras y éticas, se identifican rastros de las mismas en la literaturaperuana. De esta forma, se logra un panorama de las distintas justificaciones brindadas porlos autores peruanos. Posteriormente, se toma partido a favor de las teorías éticas de RSE, enparticular del subgrupo «teoría normativa de los grupos de interés» (stakeholder normativetheory, que ve a la RSE como ética aplicada a los negocios, exponiendo sus versiones utilitaristay deontológica, exposición que deja a esta última mejor posicionada. De esta manera, sepropone ir más allá de las justificaciones exclusivamente rentistas, según la cual el empresariodebe ser socialmente responsable porque le conviene, y considerar la deontología como lajustificación del por qué hacer RSE.

  14. Response Mixture Modeling of Intraindividual Differences in Responses and Response Times to the Hungarian WISC-IV Block Design Test

    NARCIS (Netherlands)

    Molenaar, D.; Bolsinova, M.; Rozsa, S.; De Boeck, P.


    Response times may constitute an important additional source of information about cognitive ability as it enables to distinguishing between different intraindividual response processes. In this paper, we present a method to disentangle interindividual variation from intraindividual variation in the

  15. A simplified multisupport response spectrum method (United States)

    Ye, Jihong; Zhang, Zhiqiang; Liu, Xianming


    A simplified multisupport response spectrum method is presented. The structural response is a sum of two components of a structure with a first natural period less than 2 s. The first component is the pseudostatic response caused by the inconsistent motions of the structural supports, and the second is the structural dynamic response to ground motion accelerations. This method is formally consistent with the classical response spectrum method, and the effects of multisupport excitation are considered for any modal response spectrum or modal superposition. If the seismic inputs at each support are the same, the support displacements caused by the pseudostatic response become rigid body displacements. The response spectrum in the case of multisupport excitations then reduces to that for uniform excitations. In other words, this multisupport response spectrum method is a modification and extension of the existing response spectrum method under uniform excitation. Moreover, most of the coherency coefficients in this formulation are simplified by approximating the ground motion excitation as white noise. The results indicate that this simplification can reduce the calculation time while maintaining accuracy. Furthermore, the internal forces obtained by the multisupport response spectrum method are compared with those produced by the traditional response spectrum method in two case studies of existing long-span structures. Because the effects of inconsistent support displacements are not considered in the traditional response spectrum method, the values of internal forces near the supports are underestimated. These regions are important potential failure points and deserve special attention in the seismic design of reticulated structures.


    Directory of Open Access Journals (Sweden)

    POPESCU Luminiţa Gabriela


    Full Text Available In the actual context, where globalization is moreover dynamic, the concept of solid state, well defined and territorialised is becoming diffuse while the traditional social connections (labour relations, community solidarity are becoming weaker and more fragile. The economic individualisation, migration and cultural fragmentation hold a devastating impact upon the living environment, namely significant growth of anonymity, distrust and discontent. As effect of those realities, the governments are searching responses to these processes of “social liquefaction”. Taking into consideration the fact that that the governance tools based on authority, hierarchy and bureaucracy are becoming useless due to the lack of effectiveness and legitimacy, we witness the emergence of new modes of public governance, in light to reconfigure solid ground, adequate for interventions. The design of a new type of governance should take into consideration its dual character. One component aims accountable community, as the traditional society has demonstrated that it is not able to generate spontaneously neither trust nor social capital. The second component is focused on identifying those strategies providing that accountability should be taken jointly by the public authorities and the other actors such as companies, third sector organisations and citizens. The accomplishment of such a model means to overcome several challenges. On the one hand, are the members of the community aware of the importance of their commitment? Are they truly motivated to participate in such a structure? On the other hand, how prepared are the political representatives and public authorities to accept cooperation with various categories of actors at community level? The space of strategic responsiveness introduced by the current research provides a possible scenario for responding to the above questions. Additionally, the research attempts to provide an answer to a special question


    This presentation will provide the evidence that ozone exposure in animal models induce neuroendocrine stress response and this stress response modulates lung injury and inflammation through adrenergic and glucocorticoid receptors.

  18. Growth response of tomato ( Lycopersicum esculentum Mill ...

    African Journals Online (AJOL)

    Growth response of tomato ( Lycopersicum esculentum Mill) inoculated with ... The field study attempted to validate positive responses obtained in the greenhouse. ... height and girth with the regression coefficient (r2) ranging from 0.74 to 0.96.

  19. Implications of Fiscal Responsibility on Economic Growth

    National Research Council Canada - National Science Library

    Anca Florentina Gavriluţă (Vatamanu)


    ... preserving fiscal discipline. This study tests the implications of fiscal responsibility on economic growth with the scope to analyze and find out the major issue of responsible public finances...

  20. SRB O-ring free response analysis (United States)

    Moore, Carleton J.


    The free response of viton O-rings were investigated. Two different response mechanisms of viton O-rings are identified and a theoretical representation of the two mechanisms is compared with experimental results for various temperatures.

  1. Morality, Moral Luck and Responsibility. Fortune's Web

    DEFF Research Database (Denmark)

    Nielsen, Carsten Fogh


    Anmeldelse af Nafsika Athanassoulis bog: Morality, Moral Lock and Responsibility (Palgrave MacMillian 2010)......Anmeldelse af Nafsika Athanassoulis bog: Morality, Moral Lock and Responsibility (Palgrave MacMillian 2010)...

  2. Archetypes of famine and response. (United States)

    Howe, Paul


    Famines have long been characterised by rapidly shifting dynamics: sudden price spirals, sharp increases in mortality, the media frenzy that often accompanies such spikes, the swift scaling up of aid flows, and a subsequent decline in interest. In arguing that these aspects of famine have been largely ignored in recent years due to attention to the famine process', this paper attempts to make these dynamics more explicit by applying systems thinking. It uses standard archetypes of systems thinking to explain six situations--watch, price spiral, aid magnet, media frenzy, overshoot, and peaks--that are present in many famine contexts. It illustrates their application with examples from crises in Ethiopia, Malawi, Niger, and Sudan. The paper contends that the systems approach offers a tool for analysing the larger patterns in famines and for pinpointing the most appropriate responses to them, based on an awareness of the dynamics of the crises.

  3. Responsive Social Psychologies to Animals

    Directory of Open Access Journals (Sweden)

    Dolores Galindo


    Full Text Available In this essay we approach some clues of research that move at the interface between Social Psychology and Ethology, discussing responsive relationships with animals from the contributions of Vinciane Despret. We argue that to be apart of the emerging social psychology of aspects critical in Latin America after the 1970s crisis, ethology has become not to evolutionary social psychologists interested in the study of the agency not restricted to human. What practices can bring the Ethology for Social Psychologies? Which derive stories (reencounter between the animal studies in this field translated and placed under other questions by the Social Psychologies? From a body in movement, employed as psychosocial research method, we have testimony of production which is beyond survival through pairing elements and paired opposites that lead the body to resistance limits, the limits of the human borders.

  4. Ventilatory responses to imagined exercise. (United States)

    Gallego, J; Denot-Ledunois, S; Vardon, G; Perruchet, P


    We studied whether the ventilatory responses to imagined exercise are influenced by automatic processes. Twentynine athletes produced mental images of a sport event with successive focus on the environment, the preparation, and the exercise. Mean breathing frequency increased from 15 to 22 breaths/min. Five participants reported having voluntarily controlled breathing, two of them during preparation. Twenty participants reported that their breathing pattern changed during the experiment: 11 participants were unable to correctly report on the direction of changes in frequency, and 13 incorrectly reported changes in amplitude. This finding suggests that these changes were not voluntary in most participants and may therefore reveal automatic forebrain influences on exercise hyperpnea. However, these changes may also reflect nonspecific processes (e.g., arousal) different from those occurring during actual exercise.

  5. Light Pollution Responses and Remedies

    CERN Document Server

    Mizon, Bob


    Light pollution is a major threat to astronomy across the entire developed world. The night sky that most of us can see bears little relationship to the spectacular vistas that our ancestors have gazed at for tens of thousands of years. It is ironic that as our understanding of the universe has improved, our ability to see it has been dramatically reduced by the skyglow of our civilization. In the second edition of Light Pollution - Responses and Remedies, Bob Mizon delves into the history and practice of lighting and how its misue has not only stolen the stars, but blighted our lives and those of our fellow-creatures on this planet. This book suggests how we can win back the night sky and at the same time save energy and money, improve our health, and even lower crime rate! It also includes a list of targets for urban stargazers, and recommendations for ensuring sane lighting worldwide.

  6. Arterial responses during migraine headache

    DEFF Research Database (Denmark)

    Iversen, Helle Klingenberg; Nielsen, T H; Olesen, J


    The superficial temporal artery has been thought to be the main focus of pain during migraine attacks, but its diameter has never been measured directly. The use of a new, high-resolution ultrasound machine to measure arterial size in 25 migraine patients with unilateral head pain showed...... that the lumen was wider on the painful than on the non-painful side during a migraine attack. The diameters of both radial arteries and the temporal artery on the non-painful side were smaller during than between attacks. The generalised vasoconstriction was not shared by the temporal artery on the affected...... side, which suggests a local vasodilatory response. The findings suggest that cephalic arteries may play a role in migraine pathogenesis....

  7. Academic sensemaking and behavioural responses

    DEFF Research Database (Denmark)

    Degn, Lise


    Reforms and changing ideas about what higher education institutions are and should be have put pressure on academic identity. The present paper explores the way academics in Danish universities make sense of their changing circumstances, and how this affects their perceptions of their organization......, their leaders and of themselves. The study highlights how the formal organizations’ translations of external impulses and ideas constitute a more severe threat on the perceived identity of the academic staff than the impulses and ideas themselves. The findings indicate that with the tighter couplings of top......-level management and the political system, the coupling and identification between academic staff and the formal organization may become weaker. Also, the behavioural responses perceived threats are studied, by examining the ‘us’/‘them’ categorizations of the academics, providing a burgeoning conceptual framework...

  8. Boston bombings: response to disaster. (United States)

    Hemingway, Maureen; Ferguson, Joanne


    Disasters disrupt everyone's lives, and they can disrupt the flow and function of an OR as well as affect personnel on a professional and personal level even though perioperative departments and their personnel are used to caring for trauma patients and coping with surprises. The Boston Marathon bombing was a new experience for personnel at Massachusetts General Hospital, Boston. This article discusses the incidents surrounding the bombing and how personnel at this hospital met the challenge of caring for patients and the changes we made after the experience to be better prepared in the event a response to a similar incident is needed. Copyright © 2014 AORN, Inc. Published by Elsevier Inc. All rights reserved.

  9. Crop responses to climatic variation

    DEFF Research Database (Denmark)

    Porter, John R.; Semenov, Mikhail A.


    production. However, crops can respond nonlinearly to changes in their growing conditions, exhibit threshold responses and are subject to combinations of stress factors that affect their growth, development and yield. Thus, climate variability and changes in the frequency of extreme events are important...... sufficient importance when assessing the impact of climate change for food and this is addressed. Using simulation models of wheat, the concentration of grain protein is shown to respond to changes in the mean and variability of temperature and precipitation events. The paper concludes with discussion...... resolution. This paper demonstrates the impacts of climate variability for crop production in a number of crops. Increasing temperature and precipitation variability increases the risks to yield, as shown via computer simulation and experimental studies. The issue of food quality has not been given...

  10. Macroecology of Environmental Change Response

    DEFF Research Database (Denmark)

    Jørgensen, Peter Søgaard

    Human induced changes in the earth system, such as anthropogenic climate change, cause loss of biodiversity that feed back as food, health and environmental challenges for human society. Climate change is one of the main threats to biodiversity and human society due to its global manifestation......, long interval from reduction in green house emission to cessation of warming, and the uncertain capacity of the natural systems to buffer greenhouse gas emissions. This thesis explores current challenges in our understanding of how climate change will affect biodiversity and how consequent challenges...... and European breeding bird surveys. The next four chapters in the thesis (chapters III-VI) are based on these programs. The chapters seek to answer questions about the continental-scale responses of biodiversity to climate change through investigation of population dynamics since 1980. Chapter III presents...

  11. Quantum Indeterminacy, Freedom, and Responsibility

    Directory of Open Access Journals (Sweden)

    Carlos Patarroyo


    Full Text Available In the contemporary debate between determinism and indeterminism, quantum mechanics are used by libertarianists, both as a resource to escape the determinism imposed by classical physics, and as a tool to search for a ground to the possibility of free will and moral responsibility. This paper will show that every defense of free will based on quantum mechanics has to overcome at least two objections: on the one hand what I have decided to call the scale principle , and, on the other hand Robert Kane´s luck principle . As will be shown, to answer the first objection does not imply answering the second. Through an analysis of the most recent proposals attempting to solve the latter, this paper will try to conclude that none of the proposals offers a convincing explanation of how quantum mechanics can help to solve the problem of free will. Instead, quantum mechanics seem to contribute to its complication .

  12. Transcriptomic response to differentiation induction

    Directory of Open Access Journals (Sweden)

    Dimitrov DS


    Full Text Available Abstract Background Microarrays used for gene expression studies yield large amounts of data. The processing of such data typically leads to lists of differentially-regulated genes. A common terminal data analysis step is to map pathways of potentially interrelated genes. Methods We applied a transcriptomics analysis tool to elucidate the underlying pathways of leukocyte maturation at the genomic level in an established cellular model of leukemia by examining time-course data in two subclones of U-937 cells. Leukemias such as Acute Promyelocytic Leukemia (APL are characterized by a block in the hematopoietic stem cell maturation program at a point when expansion of clones which should be destined to mature into terminally-differentiated effector cells get locked into endless proliferation with few cells reaching maturation. Treatment with retinoic acid, depending on the precise genomic abnormality, often releases the responsible promyelocytes from this blockade but clinically can yield adverse sequellae in terms of potentially lethal side effects, referred to as retinoic acid syndrome. Results Briefly, the list of genes for temporal patterns of expression was pasted into the ABCC GRID Promoter TFSite Comparison Page website tool and the outputs for each pattern were examined for possible coordinated regulation by shared regelems (regulatory elements. We found it informative to use this novel web tool for identifying, on a genomic scale, genes regulated by drug treatment. Conclusion Improvement is needed in understanding the nature of the mutations responsible for controlling the maturation process and how these genes regulate downstream effects if there is to be better targeting of chemical interventions. Expanded implementation of the techniques and results reported here may better direct future efforts to improve treatment for diseases not restricted to APL.

  13. Volcanic hazards and public response (United States)

    Peterson, Donald W.


    Although scientific understanding of volcanoes is advancing, eruptions continue to take a substantial toll of life and property. Some of these losses could be reduced by better advance preparation, more effective flow of information between scientists and public officials, and better understanding of volcanic behavior by all segments of the public. The greatest losses generally occur at volcanoes that erupt infrequently where people are not accustomed to dealing with them. Scientists sometimes tend to feel that the blame for poor decisions in emergency management lies chiefly with officials or journalists because of their failure to understand the threat. However, the underlying problem embraces a set of more complex issues comprising three pervasive factors. The first factor is the volcano: signals given by restless volcanoes are often ambiguous and difficult to interpret, especially at long-quiescent volcanoes. The second factor is people: people confront hazardous volcanoes in widely divergent ways, and many have difficulty in dealing with the uncertainties inherent in volcanic unrest. The third factor is the scientists: volcanologists correctly place their highest priority on monitoring and hazard assessment, but they sometimes fail to explain clearly their conclusions to responsible officials and the public, which may lead to inadequate public response. Of all groups in society, volcanologists have the clearest understanding of the hazards and vagaries of volcanic activity; they thereby assume an ethical obligation to convey effectively their knowledge to benefit all of society. If society resists, their obligation nevertheless remains. They must use the same ingenuity and creativity in dealing with information for the public that they use in solving scientific problems. When this falls short, even excellent scientific results may be nullified.

  14. Neurovascular responses to mental stress (United States)

    Carter, Jason R; Kupiers, Nathan T; Ray, Chester A


    The effects of mental stress (MS) on muscle sympathetic nerve activity (MSNA) and limb blood flows have been studied independently in the arm and leg, but they have not been studied collectively. Furthermore, the cardiovascular implications of postmental stress responses have not been thoroughly addressed. The purpose of the current investigation was to comprehensively examine concurrent neural and vascular responses during and after mental stress in both limbs. In Study 1, MSNA, blood flow (plethysmography), mean arterial pressure (MAP) and heart rate (HR) were measured in both the arm and leg in 12 healthy subjects during and after MS (5 min of mental arithmetic). MS significantly increased MAP (Δ15 ± 3 mmHg; P < 0.01) and HR (Δ19 ± 3 beats min−1; P < 0.01), but did not change MSNA in the arm (14 ± 3 to 16 ± 3 bursts min−1; n= 6) or leg (14 ± 2 to 15 ± 2 bursts min−1; n= 8). MS decreased forearm vascular resistance (FVR) by −27 ± 7% (P < 0.01; n= 8), while calf vascular resistance (CVR) did not change (−6 ± 5%; n= 11). FVR returned to baseline during recovery, whereas MSNA significantly increased in the arm (21 ± 3 bursts min−1; P < 0.01) and leg (19 ± 3 bursts min−1; P < 0.03). In Study 2, forearm and calf blood flows were measured in an additional 10 subjects using Doppler ultrasound. MS decreased FVR (−27 ± 10%; P < 0.02), but did not change CVR (5 ± 14%) as in Study 1. These findings demonstrate differential vascular control of the arm and leg during MS that is not associated with muscle sympathetic outflow. Additionally, the robust increase in MSNA during recovery may have acute and chronic cardiovascular implications. PMID:15705649

  15. Porcine head response to blast

    Directory of Open Access Journals (Sweden)

    Jay eShridharani


    Full Text Available Recent studies have shown an increase in the frequency of traumatic brain injuries related to blast exposure. However, the mechanisms that cause blast neurotrauma are unknown. Blast neurotrauma research using computational models has been one method to elucidate that response of the brain in blast, and to identify possible mechanical correlates of injury. However, model validation against experimental data is required to ensure that the model output is representative of in vivo biomechanical response. This study exposed porcine subjects to primary blast overpressures generated using a compressed-gas shock tube. Shock tube blasts were directed to the unprotected head of each animal while the lungs and thorax were protected using ballistic protective vests similar to those employed in theater. The test conditions ranged from 110-740 kPa peak incident overpressure with scaled durations from 1.3-6.9 ms and correspond approximately with a 50% injury risk for brain bleeding and apnea in a ferret model scaled to porcine exposure. The bulk head acceleration and the pressure at the surface of the head and in the cranial cavity were measured. Immediately after the blast, 5 of the 20 animals tested were apneic. Three subjects recovered without intervention within thirty seconds and the remaining two recovered within 8 minutes following bagging and administration of the respiratory stimulant doxapram. Gross examination of the brain revealed no indication of bleeding. Intracranial pressures ranged from 80-685 kPa as a result of the blast and were notably lower than the shock tube reflected pressures of 300-2830 kPa, indicating pressure attenuation by the skull up to a factor of 8.4. Peak head accelerations were measured from 385-3845 G’s and were well correlated with peak incident overpressure (R2=0.90. One standard deviation corridors for the surface pressure, intracranial pressure, and head acceleration are presented to provide experimental data for

  16. Dissociating stimulus-stimulus and response-response effects in the Stroop task


    Schmidt, James; Cheesman, J


    The separate semantic and response competition interactions between colour and word processing in a manual Stroop task were evaluated by comparing three trial types. Identity trials are both semantically compatible and response compatible (e.g., BLUE in the colour blue), different response trials are both semantically incompatible and response incompatible (e.g., BLUE in the colour green, where blue and green have different response keys), and same response trials are semantically incompatibl...

  17. Social responsibility of nursing: a global perspective. (United States)

    Tyer-Viola, Lynda; Nicholas, Patrice K; Corless, Inge B; Barry, Donna M; Hoyt, Pamela; Fitzpatrick, Joyce J; Davis, Sheila M


    This study addresses social responsibility in the discipline of nursing and implications for global health. The concept of social responsibility is explicated and its relevance for nursing is examined, grounded in the American Nurses Association Code of Ethics and the International Council of Nurses Code of Ethics. Social justice, human rights, nurse migration, and approaches to nursing education are discussed within the framework of nursing's social responsibility. Strategies for addressing nursing workforce issues and education within a framework of social responsibility are explored.

  18. 29 CFR 99.400 - Responsibilities. (United States)


    ... 29 Labor 1 2010-07-01 2010-07-01 true Responsibilities. 99.400 Section 99.400 Labor Office of the Secretary of Labor AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Federal Agencies and Pass-through Entities § 99.400 Responsibilities. (a) Cognizant agency for audit responsibilities...

  19. Dynamic Responsive Systems for Catalytic Function

    NARCIS (Netherlands)

    Vlatkovic, Matea; Collins, Beatrice S. L.; Feringa, Ben L.


    Responsive systems have recently gained much interest in the scientific community in attempts to mimic dynamic functions in biological systems. One of the fascinating potential applications of responsive systems lies in catalysis. Inspired by nature, novel responsive catalytic systems have been

  20. Generalizability theory and item response theory

    NARCIS (Netherlands)

    Glas, Cornelis A.W.; Eggen, T.J.H.M.; Veldkamp, B.P.


    Item response theory is usually applied to items with a selected-response format, such as multiple choice items, whereas generalizability theory is usually applied to constructed-response tasks assessed by raters. However, in many situations, raters may use rating scales consisting of items with a

  1. Corporate social responsibility and financial markets

    NARCIS (Netherlands)

    Dam, Lammertjan


    This thesis examines the economics of corporate social responsibility, with an emphasis on the role of financial markets and institutions. Questions that are raised are: What does corporate social responsibility mean in an economic context? What is the impact of corporate social responsibility on

  2. 28 CFR 542.18 - Response time. (United States)


    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Response time. 542.18 Section 542.18... REMEDY Administrative Remedy Program § 542.18 Response time. If accepted, a Request or Appeal is... later than the third calendar day after filing. If the time period for response to a Request or Appeal...

  3. Behavioral Response Research Evaluation Workshop (BRREW) (United States)


    future research directions, focusing on controlled exposure experiments ( captive and free-ranging animals ) and observational studies. key areas including controlled exposure experiments ( captive and free-ranging animals ) and observational studies on real Navy exercises; 2...include response to simulated sources of Navy sonar (BRS and captive studies), response to real Navy sources (BRS studies, M3R), incidental response

  4. Linux Incident Response Volatile Data Analysis Framework (United States)

    McFadden, Matthew


    Cyber incident response is an emphasized subject area in cybersecurity in information technology with increased need for the protection of data. Due to ongoing threats, cybersecurity imposes many challenges and requires new investigative response techniques. In this study a Linux Incident Response Framework is designed for collecting volatile data…

  5. Responsive molecular gels. : Surface Chemistry and Colloids

    NARCIS (Netherlands)

    de Jong, Jaap J. D.; Feringa, Bernard; van Esch, Jan


    A review discusses the chemo-responsive gels and physico-responsive gels. Phys. low mol. mass responsive gelators are interesting mols. with many potential applications in areas such as catalysis, sensor and sepn. technol., drug delivery, and biomedicine. In a relatively short period, a wide variety

  6. Shape Control of Responsive Building Envelopes

    DEFF Research Database (Denmark)

    Foged, Isak Worre; Kirkegaard, Poul Henning; Christensen, Jesper Thøger


    alternatives. The adaptive structure is a proposal for a responsive building envelope which is an idea of a first level operational framework for present and future investigations towards performance based responsive architectures through a set of responsive typologies. A mock-up concept of a secondary...

  7. Social responsibility as modern conception of business


    Vorona, E.


    Research of social responsibility is conducted in the context of theory of socialization of the economic systems. Approaches are considered to essence of concept «Social responsibility». The positive consequences of realization of social responsibility and its connection are certain with a competitiveness and efficiency

  8. Flexible Everything: Getting Responsive with Web Design (United States)

    Snell, Jeremy


    This article covers the basic principles of responsive web design for those interested in creating their own responsive sites from scratch, as well as noting a few frameworks that can be used to speed up development time. The author favors the Foundation CSS framework for responsive development because of its syntax, diverse selection of…

  9. 31 CFR 50.2 - Responsible office. (United States)


    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Responsible office. 50.2 Section 50.2 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM General Provisions § 50.2 Responsible office. The office responsible for the administration of the...

  10. Assessment of professional responsibilities of pharmacists towards ...

    African Journals Online (AJOL)

    The overall response rate was 86.4%. Responsibilities towards the use of vitamins/mineral supplements, nutraceuticals and herbal supplements were accepted by 85.4%, 47.5% and 24.1% of the pharmacists, respectively. The responsibilities that have most support were that of “knowledge” and “counseling” (p<0.001, ...

  11. 47 CFR 2.909 - Responsible party. (United States)


    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Responsible party. 2.909 Section 2.909... RULES AND REGULATIONS Equipment Authorization Procedures General Provisions § 2.909 Responsible party. The following parties are responsible for the compliance of radio frequency equipment with the...

  12. Electroantennogram responses of the potato tuber moth ...

    Indian Academy of Sciences (India)

    The responses to 27 compounds were evaluated, which indicated significant differences in EAGs between chemicals as well as between sexes. The fatty acid derivatives comprising essentially green leaf volatile components elicited significantly greater responses in females. The response profile of males was, in general, ...

  13. The general stress response of Bacillus subtilis

    NARCIS (Netherlands)

    van der Steen, J.B.


    The soil bacterium Bacillus subtilis responds to fluctuating conditions in its environment with a wide variety of stress responses. Apart from a series of specific responses and a series of large-scale developmental changes, B. subtilis also has a general stress response (GSR). The GSR is activated

  14. A Riparian Vegetation Ecophysiological Response Model (United States)

    Jeffrey P. Leighton; Roland J. Risser


    A mathematical model is described that relates mature riparian vegetation ecophysiological response to changes in stream level. This model was developed to estimate the physiological response of riparian vegetation to reductions in streamflow. Field data from two sites on the North Fork of the Kings River were used in the model development. The physiological response...

  15. Development of the Counselor Response Observation System (United States)

    Rantanen, Antti P.; Soini, Hannu S.


    The purpose of this study was to validate the measures included in the Counselor Response Observation System. The Counselor Response Observation System consists of the Counselor Response Coding System and the Skilled Verbal Responding Scale. Detailed results of their validity and reliability are presented.

  16. 44 CFR 9.18 - Responsibilities. (United States)


    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Responsibilities. 9.18... HOMELAND SECURITY GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.18 Responsibilities. (a) Regional Administrators' responsibilities. Regional Administrators shall, for all actions falling within...

  17. 44 CFR 201.3 - Responsibilities. (United States)


    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Responsibilities. 201.3... HOMELAND SECURITY DISASTER ASSISTANCE MITIGATION PLANNING § 201.3 Responsibilities. (a) General. This section identifies the key responsibilities of FEMA, States, and local/tribal governments in carrying out...

  18. 32 CFR 247.5 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 247.5 Section 247.5 National... DEPARTMENT OF DEFENSE NEWSPAPERS, MAGAZINES AND CIVILIAN ENTERPRISE PUBLICATIONS § 247.5 Responsibilities. (a... Commands shall: (1) Publish Combatant Command newspapers, if authorized. In discharging this responsibility...

  19. 32 CFR 235.5 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 235.5 Section 235.5 National... SALE OR RENTAL OF SEXUALLY EXPLICIT MATERIAL ON DOD PROPERTY § 235.5 Responsibilities. (a) The... its responsibilities as set forth in § 235.6. (b) The Secretaries of the Military Departments shall...

  20. 32 CFR 245.3 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 245.3 Section 245.3 National... PLAN FOR THE EMERGENCY SECURITY CONTROL OF AIR TRAFFIC (ESCAT) General § 245.3 Responsibilities. The Assistant Secretary of Defense for Networks and Information Integration will ensure the responsibilities of...

  1. 32 CFR 285.4 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 285.4 Section 285.4 National... INFORMATION ACT PROGRAM DOD FREEDOM OF INFORMATION ACT (FOIA) PROGRAM § 285.4 Responsibilities. (a) The... (listed in DoD 32 CFR part 286), and the Combatant Commands. The DA&M may delegate this responsibility to...

  2. 32 CFR 215.6 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 215.6 Section 215.6 National... EMPLOYMENT OF MILITARY RESOURCES IN THE EVENT OF CIVIL DISTURBANCES § 215.6 Responsibilities. (a) The... the accomplishment of his public affairs responsibilities set forth in paragraph (f) of this section...

  3. 32 CFR 246.5 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 246.5 Section 246.5 National... STARS AND STRIPES (S&S) NEWSPAPER AND BUSINESS OPERATIONS § 246.5 Responsibilities. (a) The Assistant to... operations that involve more than one area of responsibility. (5) Chair, as required, at the Deputy Assistant...

  4. 32 CFR 282.5 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 282.5 Section 282.5 National... Responsibilities. (a) The General Counsel of the Department of Defense (GC, DoD), or designee, shall: (1) Upon the... responsibilities under paragraph (b) of this section. (2) Render advance decisions under 31 U.S.C. 3529 and oversee...

  5. 32 CFR 281.5 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 281.5 Section 281.5 National... SETTLING PERSONNEL AND GENERAL CLAIMS AND PROCESSING ADVANCE DECISION REQUESTS § 281.5 Responsibilities. (a... accordance with this part and responsibilities promulgated under paragraph (a)(4) of this section. (2) Pay...

  6. 32 CFR 216.5 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 216.5 Section 216.5 National... § 216.5 Responsibilities. (a) The PDUSD(P&R), under the Under Secretary of Defense for Personnel and... appropriate preparations to carry out their responsibilities should a covered school be determined ineligible...

  7. 32 CFR 213.5 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 213.5 Section 213.5 National... SUPPORT FOR NON-FEDERAL ENTITIES AUTHORIZED TO OPERATE ON DOD INSTALLATIONS § 213.5 Responsibilities. (a... of non-Federal entities on DoD installations. (3) Assign responsibilities to the DoD Components to...

  8. 44 CFR 79.3 - Responsibilities. (United States)


    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Responsibilities. 79.3... § 79.3 Responsibilities. (a) Federal Emergency Management Agency (FEMA). Administer and provide... responsibilities of the “State” as the term is used in this part, as applicant or grantee, described in paragraphs...

  9. 38 CFR 1.672 - Responsibilities. (United States)


    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Responsibilities. 1.672... Administrative Control of Funds § 1.672 Responsibilities. (a) The issuance of an allotment to the administration and staff office heads (allottees) is required and is the responsibility of the Director, Office of...

  10. 32 CFR 284.5 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 284.5 Section 284.5 National... Responsibilities. (a) The General Counsel of the Department of Defense (GC, DoD) or designee shall consult on, or... Director, Defense Office of Hearings and Appeals' (DOHA) responsibilities under paragraph (b) of this...

  11. 32 CFR 277.4 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 277.4 Section 277.4 National... IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 277.4 Responsibilities. (a) The Inspector General, Department of Defense (IG, DoD), shall establish procedures for carrying out the duties and responsibilities...

  12. 32 CFR 324.4 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 324.4 Section 324.4 National... DFAS PRIVACY ACT PROGRAM General information § 324.4 Responsibilities. (a) Director, DFAS. (1) Ensures... their responsibilities pertaining to the Privacy Act. (4) Acts as the DFAS focal point on Privacy Act...

  13. 32 CFR 260.5 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 260.5 Section 260.5 National... VENDING FACILITY PROGRAM FOR THE BLIND ON DOD-CONTROLLED FEDERAL PROPERTY § 260.5 Responsibilities. (a... responsibilities of the on-site official; (3) Suspend or terminate a permit to operate a vending facility after...

  14. 32 CFR 191.5 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 191.5 Section 191.5 National... DOD CIVILIAN EQUAL EMPLOYMENT OPPORTUNITY (EEO) PROGRAM § 191.5 Responsibilities. (a) The Assistant... responsibilities. (7) Ensure fair, impartial, and timely investigation and resolution of complaints of...

  15. 32 CFR 317.4 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 317.4 Section 317.4 National... DCAA PRIVACY ACT PROGRAM § 317.4 Responsibilities. (a) The Assistant Director, Resources has overall responsibility for the DCAA Privacy Act Program and will serve as the sole appellate authority for appeals to...

  16. 30 CFR 900.4 - Responsibilities. (United States)


    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Responsibilities. 900.4 Section 900.4 Mineral... CONDUCT OF SURFACE MINING OPERATIONS WITHIN EACH STATE INTRODUCTION § 900.4 Responsibilities. (a) Each... Secretary shall grant the State exclusive responsibility and authority to implement the provisions of the...

  17. 32 CFR 231.3 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 231.3 Section 231.3 National... § 231.3 Responsibilities. (a) The Under Secretary of Defense (Comptroller) (USD(C)) shall develop and..., responsibility for paragraphs (g)(1) and (g)(2) of this section, to comptroller or resource management personnel...

  18. 32 CFR 195.5 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 195.5 Section 195.5 National... RIGHTS ACT OF 1964 § 195.5 Responsibilities. (a) The Assistant Secretary of Defense (Manpower) shall be...) to fulfill this responsibility in accordance with § 195.2(b). (c) The Assistant Secretary of Defense...

  19. 32 CFR 257.5 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 257.5 Section 257.5 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS ACCEPTANCE OF SERVICE OF PROCESS § 257.5 Responsibilities. The following responsibilities may not be...

  20. 32 CFR 205.5 - Responsibilities. (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Responsibilities. 205.5 Section 205.5 National... USE CERTIFICATES (EUCs) § 205.5 Responsibilities. (a) The Under Secretary of Defense (Acquisition... in § 205.6. This responsibility may not be delegated by the Directors of Defense Agencies; it may be...