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Sample records for subcorneal pustular dermatosis

  1. Subcorneal pustular dermatosis and eosinophilia

    Directory of Open Access Journals (Sweden)

    Madavamurthy P

    1994-01-01

    Full Text Available A young male having subcorneal pustular dermatosis is reported. The patient had characteristic skin lesions associated with itching and had typical histopathological changes. Patient also had peripheral eosinophilia and showed dramatic response to Dapsone.

  2. Subcorneal pustular dermatosis associated with Coccidioides immitis.

    Science.gov (United States)

    Iyengar, Sanjana; Chambers, Cindy J; Chang, Shurong; Fung, Maxwell A; Sharon, Victoria R

    2015-08-15

    Coccidioidomycosis (AKA "Valley fever") is a primary pulmonary infection via airborne spores released from coccidioides immitis in the soil. Reactive cutaneous eruptions resulting from the pulmonary infection are difficult to diagnose because skin biopsies do not contain the organism. We present an adolescent male with primary pulmonary C.immitis infection manifesting with biopsy proven subcorneal pustular dermatosis. Serological studies revealed increasingly positive titers for coccidioidomycosis and symptoms resolved promptly following initiation of systemic antifungal therapy. Our unique case presentation illustrates subcorneal pustular dermatosis as a reactive eruption owing to primary pulmonary coccidioidomycosis. An association between the two conditions warrants further investigation.

  3. Subcorneal Pustular Dermatosis In A Child With Congenital Hypothyroidism : Association Or Co - Incidental

    Directory of Open Access Journals (Sweden)

    Kanthraj G R

    1998-01-01

    Full Text Available Subcorneal pustular dermatosis (SCPD is a chronic benign relapsing, pustular eruption with distinctive histology1 affecting usually the females in the age group of 40 yrs. Recently, its association with hyperthyroidism has been reported2. We describe a child with congenital hypothyroidism and SCPD.

  4. Pyoderma gangrenosum associated with subcorneal pustular dermatosis and IgA myeloma.

    LENUS (Irish Health Repository)

    Ahmad, K

    2012-01-31

    We report a 57-year-old woman with a 12-year history of ulcerative pyoderma gangrenosum (PG). Five years after the onset of PG, she developed subcorneal pustular dermatosis (SPD) and biclonal IgA and IgG gammopathy. She developed PG at two bone-marrow biopsy sites, showing pathergy. Finally, she developed multiple myeloma. Although PG and SPD may occur without associated underlying malignancy, these patients should be followed up for any prospective malignancy because of the association between these disorders.

  5. Complete remission of skin lesions in a patient with subcorneal pustular dermatosis (Sneddon-Wilkinson disease) treated with antimyeloma therapy : Association with disappearance of M-protein

    NARCIS (Netherlands)

    von dem Borne, P. A.; Jonkman, M. F.; van Doorn, R.

    Subcorneal pustular dermatosis (SPD), or Sneddon-Wilkinson disease, is a rare pustular skin disease that follows a chronic relapsing course. A well-known association exists between SPD and IgA monoclonal gammopathy of undetermined significance (MGUS), which exists in up to 40% of cases. SPD has also

  6. Concurrent pyoderma gangrenosum and subcorneal pustular dermatosis in a patient with monoclonal IgA/λ gammopathy

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    Ya-Wen Hsiao

    2011-12-01

    Full Text Available Subcorneal pustular dermatosis (SPD and pyoderma gangrenosum (PG are two neutrophilic dermatoses. Coexistence of these diseases in the same patient is rare and may be a strong indicator of IgA dysglobulinemia. We describe a 69-year-old man who presented with waxing and waning flaccid pustules covering his trunk and four limbs. Poorly healing ulcerations, which usually progressed into larger nodules after debridement, were also noted. Repeated cultures were negative for bacteria, and the patient was diagnosed with SPD and PG. Serum protein electrophoresis and immunofixation revealed a monoclonal IgA lambda protein. A subsequent bone marrow biopsy revealed a normocellular marrow. While PG and SPD can occur individually in a variety of associated diseases, such as rheumatoid arthritis, systemic lupus erythematosus and inflammatory bowel disease or infection; however, their coexistence is strongly indicative of IgA dysglobulinemia.

  7. Clinical and immunological studies of 49 cases of various types of intercellular IgA dermatosis and 13 cases of classical subcorneal pustular dermatosis examined at Kurume University.

    Science.gov (United States)

    Hashimoto, T; Teye, K; Ishii, N

    2017-01-01

    Intercellular IgA dermatosis (IAD) is a subset of autoimmune bullous disease exclusively with IgA antikeratinocyte cell-surface antibodies. The classification and pathogenesis of this condition are still obscure. To classify IAD and study its pathogenesis. From our cohort of 5402 cases of autoimmune bullous disease, we selected 49 cases of various types of intercellular IgA dermatosis (IAD) and 13 cases of classical subcorneal pustular dermatosis (SPD), for which sera and information were available. We studied these cases clinically and immunologically. There were 17 SPD-type IAD, 12 intraepidermal neutrophilic IgA dermatosis (IEN)-type IAD, two IgA-pemphigus vegetans, four IgA-pemphigus foliaceus, six IgA-pemphigus vulgaris and eight unclassified IAD cases. There was no sex predominance, and the average age at disease onset was 45·9 years. Clinically, bullous and pustular skin lesions developed on various sites, particularly intertriginous areas. Histopathology showed intraepidermal blisters or pustules at the upper epidermis in the SPD-type and at the midepidermis in the IEN-type. Immunological studies revealed that direct immunofluorescence, indirect immunofluorescence of normal human skin and enzyme-linked immunosorbent assays (ELISAs) of recombinant proteins of desmogleins and desmocollins frequently showed positive results, although no antigens were detected in many cases. All cases of classical SPD, which showed no positive immunological results, were indistinguishable clinically and histopathologically from SPD-type IAD. The present study of the largest cohort of cases of IAD showed that the major subtypes are SPD and IEN, and that the combination of indirect immunofluorescence and ELISAs of desmogleins and desmocollins, in addition to direct immunofluorescence, was useful for the diagnosis of IAD and its subtypes. © 2016 British Association of Dermatologists.

  8. Neonatal pustular dermatosis: An overview

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    Sangita Ghosh

    2015-01-01

    Full Text Available Neonatal pustular eruption is a group of disorders characterized by various forms of pustulosis seen in first 4 weeks of life. Its presentation is often similar with some subtle differences, which can be further established by few simple laboratory aids, to arrive at a definite diagnosis. Given their ubiquitous presentation, it is sometimes difficult to differentiate among self-limiting, noninfectious, pustular dermatosis such as erythema toxicum neonatorum, transient neonatal pustular melanosis, miliaria pustulosa, etc., and potentially life threatening infections such as herpes simplex virus and varicella zoster virus infections. This review article tries to address the chronological, clinical, morphological, and histological differences among the various pustular eruptions in a newborn, in order to make it easier for a practicing dermatologist to diagnose and treat these similar looking but different entities of pustulation with a clear demarcation between the physiological benign pustular rashes and the infectious pustular lesions.

  9. Erosive pustular dermatosis of the scalp. A chronic recalcitrant dermatosis developed upon CO2 laser treatment

    National Research Council Canada - National Science Library

    Tavares-Bello, Rui

    2009-01-01

    Erosive pustular dermatosis of the scalp (EPDS) is a rare, chronic inflammatory dermatosis that mostly affects elderly patients, who develop erosions, pustulation, crusting and scarring on the scalp...

  10. Facial Erosive Pustular Dermatosis After Cosmetic Resurfacing.

    Science.gov (United States)

    Mervak, Julie E; Gan, Stephanie D; Smith, Emily H; Wang, Frank

    2017-10-01

    Erosive pustular dermatosis (EPD) is a rare condition that typically affects actinically damaged skin of the scalp. Characterized by sterile pustules, erosions, and crusts, EPD is difficult to treat and heals slowly. The exact cause of EPD is unknown, although trauma is an inciting factor. To describe 3 women who presented with prolonged facial erosions after cosmetic resurfacing procedures, specifically fully ablative carbon dioxide laser or medium-depth chemical peel. This case series describes the clinical features, histopathological findings, laboratory results, and treatment of 3 patients with an ultimate diagnosis most consistent with facial EPD. Patients were evaluated between September 10, 2010, and May 6, 2016, in a dermatology clinic in an academic medical center. The patients were 3 women seeking diagnostic evaluation and therapeutic options for nonhealing facial erosions occurring after ablative procedures (carbon dioxide laser resurfacing or Jessner solution/trichloroacetic acid chemical peel). Histologic examination and wound culture from initial presentation as well as clinical follow-up documenting improvement with therapeutic interventions. All 3 patients were women in their 50s or 60s for whom EPD was deemed to be the best diagnosis, after infection, immunobullous disorders, and other pustular dermatoses were considered. Histologic features were nonspecific. Treatment included a combination of topical and systemic therapies, such as corticosteroids, dapsone, isotretinoin, and/or antibiotics. Watchful waiting (tincture of time) appeared to be central to the healing process. After cosmetic resurfacing, patients may develop EPD isolated to the face. As a diagnosis of exclusion that should be considered in patients who have nonhealing wounds following ablative procedures, EPD is challenging to treat and may require the use of anti-inflammatory agents. Recognizing this condition is important, especially as cosmetic procedures become more widespread.

  11. Case report: Subcorneal pustular dermatosis in a Sudanese patient ...

    African Journals Online (AJOL)

    Herein we describe a 23-yearold Sudanese male diagnosed with SPD, based on clinical and histological findings. The presentation is unusual; pustules involving the whole body sparing palms, soles, axillae and groin. The patient recovered completely after 8 weeks treatment of 100mg/day oral dapsone. Sudanese Journal ...

  12. Erosive pustular dermatosis (chronic atrophic dermatosis of the scalp and extremities)

    OpenAIRE

    Semkova K; Tchernev G.; Wollina U

    2013-01-01

    Kristina Semkova,1 Georgi Tchernev,2 Uwe Wollina31Department of Dermatology and Venereology, Sofia Medical University, Sofia, Bulgaria; 2Policlinic for Dermatology and Venereology, Saint Kliment Ohridski University, Sofia, Bulgaria; 3Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, GermanyAbstract: Erosive pustular dermatosis is a rare noninfectious disease of the scalp or legs. Clinical findings are nonspecific, with crusts, atrophy, and ...

  13. A Case Associating an Erosive Pustular Dermatosis of the Legs and Scalp

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    Marie Jourdan

    2012-09-01

    Full Text Available Erosive pustular dermatosis (EPD of the legs and the scalp have been described as two separate entities occurring in a different context. We report the original case of a patient with an EPD of both the scalp and legs.

  14. Erosive pustular dermatosis: new description of a possible cause of the non-healing burn wound.

    Science.gov (United States)

    Al-Benna, Sammy; Johnson, Kirsty; Perkins, William; O'Boyle, Ciaran

    2014-06-01

    Erosive pustular dermatosis (EPD) is a cutaneous condition, characterised by sterile pustular lesions, erosions and crusting. Extensive or infected disease may result in scarring. EPD has never been reported following burn. The aim of this study was to describe the presentation and management of EPD complicating burns wounds. A consecutive series of EPD cases secondary to burn. Six cases were identified. In each case, erosive lesions and crusts were located at the site of burn or at the site of split skin grafting after tangential burn excision. All cases presented as failure to heal or repeated wound breakdown, despite standard burn wound management. Pain was a significant feature in all cases. Microbiological cultures demonstrated either benign colonising bacteria or no pathogens. Time to EPD diagnosis by the interdisciplinary team was 126 ± 27 days (mean ± SEM). Topical therapy with short course, potent corticosteroids resulted in clinical remission in 15 ± 2 days (mean ± SEM) without clinical relapses after 15 ± 4 months (mean ± SEM). EPD may occur following burns. EPD should be considered in the differential diagnosis of a non-healing burn wound and resolves readily with topical potent corticosteroid therapy. Copyright © 2013 Elsevier Ltd and ISBI. All rights reserved.

  15. Trichoscopic Findings of Erosive Pustular Dermatosis of the Scalp Associated with Gefitinib

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    Tomohisa Fukui

    2017-06-01

    Full Text Available Alopecia associated with epidermal growth factor receptor (EGFR inhibitor therapy is a rare cutaneous side effect with the potential to progress to scarring alopecia. Thus, dermatologists should make an early diagnosis. We present the case of a 57-year-old Japanese female with scarring alopecia associated with gefitinib, which is an EGFR inhibitor, including trichoscopic findings. The patient treated with gefitinib for non-small cell lung cancer experienced skin rash and hair loss of the scalp. The scalp lesions appeared similar to erosive pustular dermatosis of the scalp. Trichoscopic examination showed follicular keratotic plugging, milky red areas, white patches, hair shaft disorder, tapering hair, and absence of follicular opening. Histological examination showed ruptured hair follicles with a perifollicular infiltration of plasma cells, lymphocytes, and histiocytes. Oral minocycline and topical steroid treatment produced no improvement. With a reduction in the gefitinib dosage, alopecia gradually improved, although scarring remained. We consider these trichoscopic findings and suspect that follicular keratotic plugging might be a finding associated with scarring alopecia due to EGFR inhibitor therapy.

  16. Erosive pustular dermatosis of the scalp - is it really a rare condition?

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    Levakov Olivera

    2014-01-01

    Full Text Available Introduction. Erosive pustular dermatosis of the scalp (EPDS is a rare disorder of unknown etiology that usually occurs in the elderly and is characterized by multiple pustules, erosions and crusts that appear on the scalp leading to scarring alopecia. The histopathology and laboratory tests are not specific which is the reason that EPDS is a frequently misdiagnosed condition. Case report. We presented two patients with EPDS. The first patient had the known history of local trauma, both patients had chronic recidivant process, classic clinical presentations, and nonspecific histological findings. Each patient had prompt therapeutical response to potent topical steroids. Conclusion. The diagnosis of EPDS can be made if a condition fulfills the following criteria: atrophic or actinic damaged skin, clinical association of erosions, pustules, scales and crusts, no specific histopathology, no infectious agent found responsible for the condition, and chronic course leading to scarring alopecia, and prompt response to the treatment with topical steroids. The history of chemical or physical trauma is often present.

  17. Erosive pustular dermatosis of the scalp after aplasia cutis congenita in a 9-year-old patient: A 5-year follow-up.

    Science.gov (United States)

    Fertig, Raymond; Maddy, Austin; Cadore de Farias, Débora; Simão Corrêa Filho, Sandro; Rigatti, Marcelo; Tosti, Antonella

    2017-11-01

    Erosive pustular dermatosis of the scalp (EPDS) is a rare inflammatory skin disease that occurs mainly in elderly adults with a history of trauma to the scalp, but a few cases of EPDS in children have been reported. We report a rare case of EPDS after aplasia cutis congenita in a child. © 2017 Wiley Periodicals, Inc.

  18. Pustular psoriasis of pregnancy (impetigo herpetiformis)--case report.

    Science.gov (United States)

    Kondo, Rogerio Nabor; Araújo, Fernanda Mendes; Pereira, Allamanda Moura; Lopes, Vivian Cristina Holanda; Martins, Ligia Márcia Mario

    2013-01-01

    Impetigo herpetiformis is a rare dermatosis of pregnancy with typical onset during the last trimester of pregnancy and rapid resolution in the postpartum period. Clinically and histologically, it is consistent with pustular psoriasis. This similarity has led some authors to name the disease "the pustular psoriasis of pregnancy". We report the case of a patient who developed impetigo herpetiformis in two successive pregnancies.

  19. An Infant With Transient Neonatal Pustular Melanosis Presenting as Pustules

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    Pei-San Chia

    2010-12-01

    Full Text Available Transient neonatal pustular melanosis is mostly found in full-term black infants. It is a benign and self-limited disease, and the etiology is still unknown. We present a full-term female neonate with multiple vesiculopustular and pigmented macular lesions found immediately after her birth. A skin biopsy showed vesicles consisting of intracorneal and subcorneal aggregates of neutrophils, which is compatible with transient neonatal pustular melanosis. Although it is rare in Taiwan and Asian countries, transient neonatal pustular melanosis should always be considered when pustulosis is found in the neonatal period to prevent the use of unnecessary antibiotics. Dermatological consultation and histological confirmation are sometimes required for the final diagnosis.

  20. Pustular psoriasis of pregnancy (Impetigo herpetiformis) - Case report*

    Science.gov (United States)

    Kondo, Rogerio Nabor; Araújo, Fernanda Mendes; Pereira, Allamanda Moura; Lopes, Vivian Cristina Holanda; Martins, Ligia Márcia Mario

    2013-01-01

    Impetigo herpetiformis is a rare dermatosis of pregnancy with typical onset during the last trimester of pregnancy and rapid resolution in the postpartum period. Clinically and histologically, it is consistent with pustular psoriasis. This similarity has led some authors to name the disease "the pustular psoriasis of pregnancy". We report the case of a patient who developed impetigo herpetiformis in two sucessive pregnancies. PMID:24346915

  1. Generalized Pustular Psoriasis in Association with Squamous Cell Carcinoma of the Hypopharynx

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    Milicic Vesna

    2017-12-01

    Full Text Available Pustular psoriasis is an uncommon form of psoriasis consisting of widespread pustules on an erythematous background. Very rarely pustular psoriasis represent a paraneoplastic dermatosis. In this report we describe a case of generalized pustular psoriasis (GPP associated with advanced, inoperable, metastatic squamous cell carcinoma of the hypopharynx. We suggest that physicians should be alert for the worsening of existing psoriasis or formation of novel psoriasiform eruptions and should undertake clinical evaluation of possible neoplastic disease.

  2. Occupational dermatosis

    National Research Council Canada - National Science Library

    Alchorne, Alice de Oliveira de Avelar; Alchorne, Maurício Mota de Avelar; Silva, Marzia Macedo

    2010-01-01

    Occupational Dermatosis is described as any alteration in the skin, mucosa or annexes that is directly or indirectly caused, conditioned, maintained or aggravated by agents present in the occupational...

  3. Dermatosis neglecta.

    Science.gov (United States)

    Sasaya, Elisa Mayumi Kubo; Ghislandi, Carolina; Trevisan, Flávia; Ribeiro, Talita Beithum; Mulinari-Brenner, Fabiane; Gaiewski, Caroline Balvedi

    2015-01-01

    Dermatosis neglecta is the name of a skin condition characterized by papules and polygonal plaques, which are sometimes warty, brownish and hyperpigmented, adherent and symmetric, though removable with ethyl or isopropyl alcohol. It occurs due to inadequate skin cleansing causing accumulation of sebum, sweat, keratin and impurities. Its occurrence, though little reported, is frequent. The main differential diagnosis is the Terra firma-forme dermatosis. The treatment is simple, with exfoliation, moisturizing and even rubbing of alcohol. Causes of negligence on the patient's side, which can range from hygiene carelessness to psychiatric disorders, local hypersensitivity, limbs negligence or motor paralysis, should be investigated. We illustrate the case of dermatosis neglecta in a 45-years old patient admitted with pulmonary sepsis.

  4. Evaluation of the Effectiveness of Antibiotics against Eosinophilic Pustular Folliculitis

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    Sachiko Ono

    2013-05-01

    Full Text Available Eosinophilic pustular folliculitis (EPF is a chronic intractable pruritic dermatosis. Although indomethacin is generally effective against EPF and considered as a first-line therapy, quite a few patients with indomethacin still suffer from the symptoms. Among other therapeutic options, some antibiotics have been reported to be effective; however, there has been no epidemiological description regarding oral antibiotics use in patients with EPF. In this study, we investigated the frequency of antibiotics use and the effectiveness in patients with EPF.

  5. Dermatosis associated with menopause

    National Research Council Canada - National Science Library

    Nair, Pragya A

    2014-01-01

    .... Dermatosis seen due to estrogen deficiency includes Atrophic Vulvovaginitis, Vulvar Lichen Sclerosus, Dyaesthetic Vulvodynia, Hirsutism, Alopecia, Menopausal Flushing, Keratoderma Climactericum...

  6. Pustular psoriasis: pathophysiology and current treatment perspectives

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    Benjegerdes KE

    2016-09-01

    Full Text Available Katie E Benjegerdes,1 Kimberly Hyde,2 Dario Kivelevitch,3 Bobbak Mansouri1,4 1Texas A&M Health Science Center College of Medicine, Temple, 2Texas A&M Health Science Center College of Medicine, Round Rock, 3Division of Dermatology, Baylor University Medical Center, Dallas, 4Department of Dermatology, Scott and White Hospital, Texas A&M Health Science Center College of Medicine, Temple, TX, USA Abstract: Psoriasis vulgaris is a chronic inflammatory disease that classically affects skin and joints and is associated with numerous comorbidities. There are several clinical subtypes of psoriasis including the uncommon pustular variants, which are subdivided into generalized and localized forms. Generalized forms of pustular psoriasis include acute generalized pustular psoriasis, pustular psoriasis of pregnancy, and infantile and juvenile pustular psoriasis. Localized forms include acrodermatitis continua of Hallopeau and palmoplantar pustular psoriasis. These subtypes vary in their presentations, but all have similar histopathologic characteristics. The immunopathogenesis of each entity remains to be fully elucidated and some debate exists as to whether these inflammatory pustular dermatoses should be classified as entities distinct from psoriasis vulgaris. Due to the rarity of these conditions and the questionable link to the common, plaque-type psoriasis, numerous therapies have shown variable results and most entities remain difficult to treat. With increasing knowledge of the pathogenesis of these variants of pustular psoriasis, the development and use of biologic and other immunomodulatory therapies holds promise for the future of successfully treating pustular variants of psoriasis. Keywords: psoriasis, pustular psoriasis, generalized pustular psoriasis, von Zumbusch, impetigo herpetiformis, acrodermatitis continua of Hallopeau, palmoplantar pustulosis, biologic

  7. Dermatoses Ocupacionais Occupational dermatosis

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    Alice de Oliveira de Avelar Alchorne

    2010-04-01

    Full Text Available Dermatose ocupacional é qualquer alteração da pele, mucosa e anexos, direta ou indiretamente causada, condicionada, mantida ou agravada por agentes presentes na atividade ocupacional ou no ambiente de trabalho. Os autores referem a importância do tema, a epidemiologia e a etiopatogenia das principais dermatoses ocupacionais: dermatites de contato irritativas e alérgicas, fitodermatites, acnes (elaioconiose e cloracne, ceratoses, cânceres, granulomas de corpo estranho, infecções, oníquias e ulcerações. A clínica da dermatose ocupacional é apresentada em diferentes profissões. Analisam-se os exames laboratoriais pedidos nessas dermatoses, com especial destaque para testes de contato, que são o padrão ouro, e fornecem-se dados do tratamento e prevenção; quanto à prevenção da dermatose ocupacional, informam-se as medidas coletivas e individuais, especialmente, no que respeita ao uso adequado dos equipamentos de proteção individual.Occupational Dermatosis is described as any alteration in the skin, mucosa or annexes that is directly or indirectly caused, conditioned, maintained or aggravated by agents present in the occupational activity or work environment. The authors of the present study describe the importance of the topic and the epidemiology and etiopathogeny of the main forms of occupational dermatoses: allergic and irritative contact dermatitis, phytodermatitis, acne (elaioconioses and chloracne, keratosis, cancers, foreign body granuloma, infections, onychias, and ulcerations. Clinical findings of occupational dermatosis are presented in relation to various professions. Laboratory tests used to diagnose this condition are analysed, with special emphasis on patch testing, which is the gold standard. Information about the treatment and prevention of this disorder is provided. Collective and individual measures, especially regarding the proper use of individual protection equipment for the prevention of occupational

  8. Dermatosis del adolescente

    OpenAIRE

    María Luisa, Pérez-Cotapos S.

    2011-01-01

    Durante la adolescencia se producen cambios importantes en la piel que son motivo de consulta frecuente al especialista. Estos son producidos por múltiples factores, dentro de los cuales están los hormonales, inmunológicos, psicológicos y los psicosociales. Las dermatosis más frecuentes son: el acné, en sus distintas formas clínicas, que afecta a más del 90% de los adolescentes en distintos grados de severidad; la dermatitis seborreica; las alopecias no cicatriciales; hiperhidrosis y dishi...

  9. Prevalence of Dermatosis During Childhood

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    Handan Saçar

    2010-10-01

    Full Text Available Background and Design: The aim of this study was to determine the distribution of skin diseases during childhood.Material and Method: A retrospective descriptive study was planned. Among 18318 patients referred to our dermatology outpatient clinic between September 2004 and November 2009, 1756 child patients between 0-12 years of age were retrospectively analyzed from automation record system. Results: A total of 1756 child patients who referred during the study period were included in the study; 791 patients were male (45.05% and 965 were female (54.95%. The most frequently seen disease group was eczema (26.0%, followed by infectious dermatosis (20.6% and eritematous squamous dermatosis (9.9%. Atopic dermatitis (8.0%, viral dermatosis (11.7% and seborrheic dermatitis (7.1% were the most frequently encountered diseases in eczema, infectious dermatosis and eritematous squamous dermatosis groups, respectively. Conclusion: We found that 56.5% of the diseases determined were composed of eczemas, infectious dermatosis and eritematous squamous dermatosis.

  10. Eosinophilic Dermatosis of Hematologic Malignancy.

    Science.gov (United States)

    Lucas-Truyols, S; Rodrigo-Nicolás, B; Lloret-Ruiz, C; Quecedo-Estébanez, E

    Dermatosis characterized by tissue eosinophilia arising in the context of hematologic disease is known as eosinophilic dermatosis of hematologic malignancy. The most commonly associated malignancy is chronic lymphocytic leukemia. Eosinophilic dermatosis of hematologic malignancy is a rare condition with a wide variety of clinical presentations, ranging from papules, erythematous nodules, or blisters that simulate arthropod bites, to the formation of true plaques of differing sizes. Histology reveals the presence of abundant eosinophils. We present 4 new cases seen in Hospital Arnau de Vilanova, Valencia, during the past 7 years. Three of these cases were associated with chronic lymphocytic leukemia and 1 with mycosis fungoides. It is important to recognize this dermatosis as it can indicate progression of the underlying disease, as was the case in 3 of our patients. Copyright © 2017 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.

  11. Terra firma-forme dermatosis

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    Emel Erkek

    2012-01-01

    Full Text Available Terra firma-forme dermatosis is characterized by ′dirty′ brown-grey cutaneous patches and plaques that can simply be eradicated by forceful swabbing with alcohol pads. The pathogenesis has been attributed to abnormal and delayed keratinization. Although affected patients present with typical lesions, the disorder is not well-known by dermatologists. In this report, we describe two patients with terra firma-forme dermatosis in the setting of xerosis cutis and atopic dermatitis. From a clinical point of view, we lay emphasis on its unique expression and diagnosis/treatment. From a histological perspective, we highlight its resemblance to dermatosis neglecta and speculate on the role of ′neglect′ in a patient with seemingly adequate hygiene. The role of urea containing emollients in the development of this disorder remains to be determined.

  12. Ashy dermatosis: A controversial entity

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    Nandini Chakrabarti

    2012-01-01

    Full Text Available We present here the case of a young Indian male with slowly progressive, diffuse darkening of the face, arms, neck, and trunk. The patient was not taking any medication and there was no history of any previous skin disease and the mucous membrane was not involved. These findings are consistent with a diagnosis for ashy dermatosis of unknown etiology.

  13. Pustular Dermatitis Caused by Dermatophilus congolensis▿

    Science.gov (United States)

    Burd, Eileen M.; Juzych, Lydia A.; Rudrik, James T.; Habib, Fadi

    2007-01-01

    We describe a case of pustular dermatitis in a 15-year-old girl who had just returned from horseback riding camp. Based on gram staining, colony characteristics, biochemical reactions, and whole-cell fatty acid analysis, the causative agent was identified as Dermatophilus congolensis. The literature contains few reports of human infection with this organism. PMID:17376877

  14. Pustular Dermatitis Caused by Dermatophilus congolensis▿

    OpenAIRE

    Burd, Eileen M.; Juzych, Lydia A.; Rudrik, James T.; Habib, Fadi

    2007-01-01

    We describe a case of pustular dermatitis in a 15-year-old girl who had just returned from horseback riding camp. Based on gram staining, colony characteristics, biochemical reactions, and whole-cell fatty acid analysis, the causative agent was identified as Dermatophilus congolensis. The literature contains few reports of human infection with this organism.

  15. Pustular dermatitis caused by Dermatophilus congolensis.

    Science.gov (United States)

    Burd, Eileen M; Juzych, Lydia A; Rudrik, James T; Habib, Fadi

    2007-05-01

    We describe a case of pustular dermatitis in a 15-year-old girl who had just returned from horseback riding camp. Based on gram staining, colony characteristics, biochemical reactions, and whole-cell fatty acid analysis, the causative agent was identified as Dermatophilus congolensis. The literature contains few reports of human infection with this organism.

  16. [Dermatosis-arthritis syndrome associated with Crohn's disease in a teenager].

    Science.gov (United States)

    Guerre-Schmidt, A-R; Pelletier, F; Carbonnel, F; Humbert, P; Aubin, F

    2006-11-01

    Pustulosis, erythema nodosum, arthritis and systemic manifestations are associated in the dermatosis-arthritis syndrome. It is a well recognized complication of the bowel ileo-jejunal bypass but it is also associated with inflammatory bowel diseases. We report the case of an adolescent who presented with a dermatosis-arthritis syndrome associated to a Crohn's disease during a referring for pustulosis, erythema nodosum and fever. The evolution is complicated by proctorragia. Colonoscopy and intestinal biopsy found a Crohn's disease. Cutaneous and intestinal symptoms quickly improved with systemic corticosteroids. The dermatosis-arthritis syndrome can be associated with bowel bypass and with inflammatory bowel disease, more frequently with ulcerative colitis than with Crohn's disease. It consists in a vesiculo-pustular eruption, erythema nodosum, fever, arthritis and ocular manifestations. Histopathology bears a strong resemblance with Sweet's syndrome. Physiopathology implicates microbial proliferation, formation of immune complex against skin and activation and migration of neutrophils and increasing factors. The treatment is based on corticosteroids and non steroid anti-inflammatory drugs or dapsone.

  17. Neutrophilic dermatosis of dorsal hands

    OpenAIRE

    KAUR, S.; Gupta, D.; Garg, B; Sood, N.

    2015-01-01

    Sweet′s syndrome is characterized by erythematous tender nodules and plaques over face and extremities. Fever, leukocytosis with neutrophilia, and a neutrophilic infiltrate in the dermis are characteristic features. Neutrophilic dermatosis of dorsal hands is a rare localized variant of Sweet′s syndrome occurring predominantly over dorsa of hands. Various degrees of vascular damage may be observed on histopathology of these lesions. Both Sweet′s syndrome and its dorsal hand variant have been r...

  18. Terra firma-forme dermatosis.

    Science.gov (United States)

    Unal, Emine; Guarneri, Claudio; Chokoeva, Anastasiya Atanasova; Wollina, Uwe; Tchernev, Georgi

    2017-03-01

    Terra firma-forme dermatosis (TFFD) belongs to the group of "dirty dermatoses" and represents a not well-known and surely underestimated vexing skin condition. Firstly described by Duncan, Tschen and Knox in 1987, it accounts for a few case series in the literature and has a still undefined aetiology. The authors present an additional report of TFFD, occurring in a young Caucasian girl, and briefly review the current medical literature on the topic.

  19. Immunoglobin assay in localzed pustular psoriasis

    Directory of Open Access Journals (Sweden)

    Mittal R

    1993-01-01

    Full Text Available Immunoglobulin (lgG, lgM and lgA levels were studied in 50 patients of localized pustular psoriasis (LPP. Alteration of immunoglobulin levels was observed in 49/50 cases. IgG, lgM and lgA all were increased in 18 cases, lgG and lgA in 16 cases, lgG and lgM in 2 cases and lgA alone in 1 case. On the other hand, lgM alone was decreased in 11 cases, lgM and lgA both were decreased in 5 patients. IgG alone was raised statistically significantly in LPP. Increase in lgG was more in LPP with duration of disease upto 2 years / with duration of disease more than 2 years and in acropustulosis (AP/chronic palmoplantar pustular psoriasis (Ch PPP.

  20. [Terra firma-forme dermatosis].

    Science.gov (United States)

    Pallure, V; Ameline, M; Plantin, P; Bessis, D

    2013-11-01

    Terra firma-forme (i.e. resembling dry earth) is a condition chiefly affecting children wrongly considered as dermatosis arising out of negligence and inadequate corporal hygiene. It is in fact an acquired and asymptomatic grey-brown hyperpigmentation of the skin that persists despite normal washing with soap and water, but which subsides on rubbing with isopropyl alcohol 70%. Herein we report 10 new cases of this disorder. Ten patients aged between 7 months in 17 years were seen for acquired macular skin pigmentation, either brown or grey, fragmented and confluent. In six patients, this abnormality was the main reason for the consultation, generally on aesthetic grounds, and more rarely for diagnosis or suspicion of acanthosis nigricans. In all cases, questioning revealed normal hygiene measures. The condition comprised macular or acquired papular pigmentation, either brown or grey, of bilateral and symmetrical disposition and electively affecting the neck, trunk and retro-malleolar area of the ankles. Clinical examination together with a test involving rubbing with isopropyl alcohol 70° confirmed the diagnosis, revealing healthy underlying skin. Terra firma-forme dermatosis is frequently seen in clinical practice but is largely ignored in the French literature, possibly because of relevant indifference towards the condition. It affects both sexes equally, with no predilection for age or ethnicity, although it is classically seen to a greater extent during adolescence. Diagnosis of the condition, which is easily made thanks to the hyperpigmentation of dirty brown appearance on the neck and the ankles in particular, should not mislead the practitioner into blaming patients for supposedly deficient body hygiene. Knowledge of this form of dermatosis is useful because of its potentially harmful aesthetic and social effects, despite the ease of treatment by insistent rubbing of the affected areas with medical alcohol or ether. Early recognition also avoids pointless

  1. Neutrophilic dermatosis of dorsal hands

    Directory of Open Access Journals (Sweden)

    S Kaur

    2015-01-01

    Full Text Available Sweet′s syndrome is characterized by erythematous tender nodules and plaques over face and extremities. Fever, leukocytosis with neutrophilia, and a neutrophilic infiltrate in the dermis are characteristic features. Neutrophilic dermatosis of dorsal hands is a rare localized variant of Sweet′s syndrome occurring predominantly over dorsa of hands. Various degrees of vascular damage may be observed on histopathology of these lesions. Both Sweet′s syndrome and its dorsal hand variant have been reported in association with malignancies, inflammatory bowel diseases, and drugs. We report a patient with neutrophilic dermatoses of dorsal hands associated with erythema nodosum. He showed an excellent response to corticosteroids and dapsone.

  2. Terra Firma-forme Dermatosis

    Directory of Open Access Journals (Sweden)

    Anagha Ramesh Babu

    2013-01-01

    Full Text Available Terra firma-forme dermatosis is a cutaneous discoloration. ‘Dirty’ brown grey cutaneous patches and plaques that can be rid off by forceful swabbing with alcohol pads characterize it. The pathogenesis has been attributed to abnormal and delayed keratinization. It poses no medical threat. A 40-year-old male patient presented to the Department of Dermatology with a 2-3 month history of persistent pigmented patches on both upper arms. The lesions were not associated with itching or burning sensation. He gives no history of exacerbation on exposure to the sun.

  3. Lichen planus pigmetosus-like ashy dermatosis

    Directory of Open Access Journals (Sweden)

    Francesco Tripodi Cutrì

    2011-12-01

    Full Text Available Ashy dermatosis, also known as erythema dyschromicum perstans, is an idiopathic dermal melanosis of unknown etiology. We here describe an unusual case of 63-year-old Caucasian male with ashy dermatosis and skin lesion of lichen pigmentosus-like. No treatment was tried because the lesions were totally asymptomatic. After a control, three months later, all lesions had cleared up. This case is of interest because it proves the existence of ashy dermatosis with clinical aspect lichen planus pigmentosus-like. This is the first case in the literature of lichen planus pigmentosuslike ashy dermatosis confirming the view that ashy dermatosis is a variant of lichen planus without the typically band-like infiltrate and Max Joseph spaces.

  4. Ecstasy pimples - a new facial dermatosis.

    Science.gov (United States)

    Wollina, U; Kammler, H J; Hesselbarth, N; Mock, B; Bosseckert, H

    1998-01-01

    Ecstasy (XTC) has become a popular drug in the rave, dance and techno scene. Several severe disorders due to drug addiction have been described but no dermatological symptoms. We report on 2 patients (20-year-old female, 21-year-old male) with medical problems after taking XTC. Both developed a facial rash with reddish pimples after oral intake of XTC. The distribution resembled either periorificial dermatosis or acneiform rash without white- or blackheads. The lesions cleared without specific treatment. We suggest that XTC pimples represent an acneiform dermatosis in young people taking designer drugs. Though the dermatosis itself seems to be mild, it may be a cutaneous marker for drug abuse.

  5. Pustular dermatitis in dogs affected by leishmaniosis: 22 cases.

    Science.gov (United States)

    Colombo, Silvia; Abramo, Francesca; Borio, Stefano; Albanese, Francesco; Noli, Chiara; Dedola, Carla; Leone, Federico

    2016-02-01

    Skin lesions in canine leishmaniosis (CanL) are diverse, including exfoliative, ulcerative, nodular and papular dermatitides. An uncommon pustular form has also been reported. We hypothesized that CanL infection can produce a pustular reaction pattern in the skin of dogs. The aim of this retrospective study was to describe the clinicopathological features of dogs with CanL infection and pustular dermatitis, and correlate them with response to therapy. Twenty two affected dogs. Retrospective review of medical records and examination of archived biopsy materials or previously processed glass slides was performed. Cytological examinations had been recorded for all cases. Specimens were available for histopathological examination in 17 of 22 cases and for immunohistochemical detection of Leishmania amastigotes in 13 of 22 cases. All dogs presented with multifocal to diffuse pustular dermatitis. CanL was diagnosed by IFAT serology (20 cases), bone marrow cytology (one case) or bone marrow PCR (one case). Cytological and/or histopathological examinations revealed acantholytic keratinocytes within pustules in 18 of 22 cases. Bacterial and fungal cultures were not performed. Leishmania amastigotes were identified by histopathology within the dermis in three cases; immunohistochemistry was positive in four cases. All dogs underwent concurrent anti-leishmanial and immunosuppressive therapy to control the pustular dermatitis, with favourable outcome in 11 of 22 cases. Due to the retrospective nature of this study it is not possible to either accept or reject the hypothesis that CanL is the direct cause of pustular dermatitis. © 2015 ESVD and ACVD.

  6. Facial dermatosis associated with Demodex: a case-control study*

    OpenAIRE

    Zhao, Ya-e; Peng, Yan; Wang, Xiang-lan; Wu, Li-ping; Wang, Mei; Yan, Hu-ling; Xiao, Sheng-Xiang

    2011-01-01

    Demodex has been considered to be related with multiple skin disorders, but controversy persists. In this case-control study, a survey was conducted with 860 dermatosis patients aged 12 to 84 years in Xi’an, China to identify the association between facial dermatosis and Demodex. Amongst the patients, 539 suffered from facial dermatosis and 321 suffered from non-facial dermatosis. Demodex mites were sampled and examined using the skin pressurization method. Multivariate regression analysis wa...

  7. Two Cases of Unilateral Ashy Dermatosis

    Directory of Open Access Journals (Sweden)

    Hisayoshi Imanishi

    2011-01-01

    Full Text Available Ashy dermatosis is a typically asymptomatic disease of unknown origin that causes symmetrical gray spots to appear on the trunk and extremities. We report 2 cases of ashy dermatosis with unilateral distribution. To our knowledge, only 5 cases of ashy dermatosis with unilateral lesion have been reported so far. Case 1: an 11-year-old woman presented with asymptomatic slate-gray pigmented plaques on the left trunk and left upper arm. The skin biopsy specimen demonstrated a mild lymphohistiocytotic infiltrate in the upper dermis with epidermal and dermal melanosis. Q-Switched ruby laser did not improve such lesions. Case 2: a 21-year-old man was referred to our hospital because of asymptomatic slate-gray pigmented plaques on the left trunk and left upper arm. Histopathological findings were compatible with a mild lymphocytic infiltration with melanin incontinence in the upper dermis. The mechanism that governs unilateral distribution of ashy dermatosis, including in our cases, remains unclear.

  8. Linear IgA Bullous Dermatosis

    DEFF Research Database (Denmark)

    Lings, Kristina; Bygum, Anette

    2015-01-01

    Linear IgA bullous dermatosis (LAD) is an autoimmune, chronic bullous disease affecting primarily young children and adults. Studies on LAD are relatively sparse and from Scandinavia we could only find a few case reports. Therefore we decided to conduct a retrospective investigation of patients...

  9. Generalized pustular psoriasis of pregnancy successfully treated with cyclosporine

    Directory of Open Access Journals (Sweden)

    Hazarika Debeeka

    2009-01-01

    Full Text Available Two multigravidae aged 27 and 29 years, with previous uneventful pregnancies, second being psoriatic, reported at 24 and 28 weeks of pregnancies, with generalized pustular lesions. Laboratory findings, including serum calcium were normal. Ultrasonography showed normal fetal growth. Histopathology confirmed pustular psoriasis. Patients were put on cyclosporine 3 mg/ kg weight/ day after failure of an initial systemic steroid. Blood pressure, pulse, and fetal heart sounds were recorded every 12 hours, and ultrasonography and blood parameters, biweekly. Cyclosporine was tapered and stopped after delivery of two healthy babies at 38 weeks. We conclude that cyclosporine can be an option in the management of pustular psoriasis of pregnancy or psoriasis with pustulation in pregnancy.

  10. Linear IgA Bullous Dermatosis

    DEFF Research Database (Denmark)

    Lings, Kristina; Bygum, Anette

    2015-01-01

    Linear IgA bullous dermatosis (LAD) is an autoimmune, chronic bullous disease affecting primarily young children and adults. Studies on LAD are relatively sparse and from Scandinavia we could only find a few case reports. Therefore we decided to conduct a retrospective investigation of patients s...... is a rare but characteristic condition which in most cases can be effectively treated with dapsone or sulphapyridine....

  11. Highlighting Interleukin-36 Signalling in Plaque Psoriasis and Pustular Psoriasis.

    Science.gov (United States)

    Furue, Kazuhisa; Yamamura, Kazuhiko; Tsuji, Gaku; Mitoma, Chikage; Uchi, Hiroshi; Nakahara, Takeshi; Kido-Nakahara, Makiko; Kadono, Takafumi; Furue, Masutaka

    2018-01-12

    Plaque psoriasis and pustular psoriasis are overlapping, but distinct, disorders. The therapeutic response to biologics supports the pivotal role of the tumour necrosis alpha (TNF-?)/ interleukin (IL)-23/IL-17/IL-22 axis in the pathogenesis of these disorders. Recently, functional activation of the IL-36 receptor (IL-36R) was discovered to be another driving force in the pathogenesis of psoriasis. This was first highlighted by the discovery that a loss-of-function mutation of the IL-36R antagonist (IL-36Ra) causes pustular psoriasis. Although the TNF-?/IL-23/IL-17/IL-22 axis and the functional activation of IL-36R are fundamentally involved in plaque psoriasis and pustular psoriasis, respectively, the 2 pathways are closely related and mutually reinforced, resulting in full-blown clinical manifestations. This review summarizes current topics on how IL-36 agonists (IL-36?, IL-36?, IL-36?) signal IL-36R, the pathological expression of IL-36 agonists and IL-36Ra in plaque and pustular psoriatic lesions, and the cross-talk between the TNF-?/IL-23/IL-17/IL-22 axis and the functional activation of IL-36R in the epidermal milieu.

  12. Terra firma-forme dermatosis: A report of ten individuals with Duncan's dirty dermatosis and literature review.

    Science.gov (United States)

    Greywal, Tanya; Cohen, Philip R

    2015-07-01

    Terra-firma forme dermatosis, also known as Duncan's dirty dermatosis, is a benign skin condition that presents as dirt-like plaques in patients of all ages. We describe a series of ten patients that presented with terra-firma forme dermatosis. We reviewed PubMed for the following terms: dermatosis, Duncan's dirty dermatosis, isopropyl alcohol, terra firma, and terra firma-forme dermatosis. We also reviewed papers containing these terms and their references. The diagnosis of terra firma-forme dermatosis was confirmed in all patients who had complete resolution of each lesion after the application of 70% isopropyl alcohol. Terra-firma forme dermatosis is easily diagnosed and treated with 70% isopropyl alcohol. It is important to recognize this benign dermatologic condition since it can be confused with other cutaneous disorders. Therefore, in order to avoid unnecessary referrals, biopsies, blood tests, and medications, we suggest a trial of wiping the skin lesion with 70% isopropyl alcohol pads when the diagnosis of terra-firma forme dermatosis is considered.

  13. Dermatosis in children with oedematous malnutrition (Kwashiorkor)

    DEFF Research Database (Denmark)

    Heilskov, S; Rytter, Maren Johanne Heilskov; Vestergaard, C

    2014-01-01

    Children with oedematous malnutrition, known as kwashiorkor, may develop a characteristic skin lesion, named 'Dermatosis of Kwashiorkor' (DoK). Only a few studies have been concerned with this condition, and the reason for the development of DoK remains unexplained. This study review the existing...... studies concerning DoK, including its clinical manifestations, histopathology, suggested pathophysiology, current treatment and prognosis for children of the age of 6 months to 5 years. Standardized clinical studies are needed to further understand the implications of DoK. Such studies would suffer from...

  14. A case of pemphigus foliaceus and pustular psoriasis A case of pemphigus foliaceus and pustular psoriasis with a brief review of literature

    Directory of Open Access Journals (Sweden)

    Darjani Abbas

    2017-10-01

    Full Text Available Rarely pemphigus foliaceus could be associated with generalized pustular psoriasis. A 66-year-old woman with diffuse flaccid bullae and erosions of pemphigus foliaceus underwent two sessions of pulse therapy of corticosteroid and oral prednisolone during the interval time. Two weeks after the second session of pulse therapy with improvement of the lesions, during tapered dosage of oral prednisolone, facial annular erythematous lesions appeared and were superimposed by generalized pustular eruptions. Skin biopsy of pustular lesions showed pustular psoriasis so intramuscular methotrexate was added. Two years later, during decreasing dosage of methotrexate and prednisolone, she had eruptive recurrence of pustules and flaccid bullae associated with erythroderma and fever which were controlled with increasing dosage of corticosteroid and starting oral retinoid. These hypotheses may explain co-occurring pemphigus foliaceus and pustular psoriasis: decreasing dosage of corticosteroid, interleukin-8 overproduction in keratinocytes and increased activity of plasminogen activator in skin lesions.

  15. Kejadian Dermatosis yang Tinggi pada Anjing Jalanan di Bali (A HAIGH DERMATOSIS INCIDENCE AMONG STRAY DOGS IN BALI

    Directory of Open Access Journals (Sweden)

    I Kadek Saka Wiryana

    2014-08-01

    Full Text Available This study was designed to investigate the incidence of dermatosis among stray dogs in Bali. A totalof 401 stray dogs collected in the animal shelter of Bali Animal Welfare Association during 2011 wasinvestigated in this study. Dogs were examined by the clinical sign and continued by skin scraping, cytologyand wood lamp examination. In total, 37,9% sample were positive for dermatosis. Bacterial causeddermatosis found to be the most prevalent (23,6%, followed by tick and fleas (16.5%, scabies (12.7%,malassezia (8.2%, demodek (8% and ringworm (4.5% respectively. We also found that dermatosis weremore prevalent in male dogs (50.9% rather than female dogs (32.9%. Dogs 9-12 weeks old were moreheavily infected (45.8% than other group. In conclusion, the incidence of dermatosis among stray dogs inBali is relatively high. This may need serious awareness as some of this dermatosis were zoonotic tohuman.

  16. Features of Terra Firma-Forme Dermatosis.

    Science.gov (United States)

    Aslan, Nurşad Çifci; Güler, Şükran; Demirci, Kamile; Isiyel, Emel

    2018-01-01

    Terra-firma-forme dermatosis (TFFD) is a little known hyperpigmented skin disease that is more common than expected. We examined retrospectively the medical records of 79 patients: 88.6% were children, the mean age was 10.4 years (SD = 7.5 years), and 64.6% were female. The dermatoses were found on the trunk in 27.8%, extremities in 26.6%, fold zones in 8.9%, and head in 2.5% of the patients. The lesions appeared in more than 1 location in 34.2% of the patients and were symmetrically located 77.2% of the time. Swabbing with alcohol is sufficient for diagnosis and treatment. TFFD, mostly seen in children and female patients, should be kept in mind to avoid unnecessary diagnostic testing and treatment. © 2018 Annals of Family Medicine, Inc.

  17. Unusually severe case of dermatosis neglecta.

    Science.gov (United States)

    Turrentine, Jake E; Blalock, Travis W; Davis, Loretta S

    2012-01-01

    An 18-year-old black woman with cerebral palsy was admitted for evaluation of an intrathecal baclofen pump site infection. The dermatology service was consulted for treatment suggestions of a presumed diagnosis of chronic tinea capitis. Three courses of oral griseofulvin during the past 2 years failed to resolve the patient's chronic scalp dermatosis. Scalp lesions first began about 2 years earlier after hospitalization for placement of an intrathecal baclofen pump. The patient was unable to care for her scalp due to her cerebral palsy, and her mother interpreted the scalp condition as infectious. No routine shampoo care, scalp care, or topical treatment was performed for more than 1 1/2 years. The mother felt that touching the patient's scalp might cause pain and noted that the majority of her time was spent concentrating on more critical medical issues. Physical examination revealed coalescing hyperkeratotic plaques extending dorsally from the anterior hairline to the occipital scalp with small flecks of keratinous debris throughout the remaining hair (Figure 1). The plate-like plaques were devoid of hair, except at a few fissures where a few tufts of hair emerged. No cervical lymph nodes were appreciated on palpation. Treatment was initiated with compresses consisting of large warm water-soaked towels 4 times daily. Three times a day, a nursing staff applied 5% salicylic acid in olive oil to the scalp under a shower cap for approximately 1 hour. Over the following 2 days, a significant reduction in keratinous debris was appreciated. Within 2 weeks, the bulk of the plaques had been removed (Figure 2). At 6-week follow-up, the underlying scalp showed areas of fibrosis and possible scarring with a few emerging tufts of hair. On the basis of history and response to treatment with salicylic acid and routine scalp care, the patient was diagnosed with an unusually severe case of dermatosis neglecta.

  18. Ashy dermatosis : A case of cinderella

    Directory of Open Access Journals (Sweden)

    Hasnaa Zaouri

    2015-12-01

    Full Text Available We report the case of a 20-years old female, who presented anasymptomatic  grayish macules affecting the neck, trunk and roots of legs (Panel A. Histopathologic examination showed  an increased dermal melanophages (Panel B and a vacuolization of basal cell layer (Panel C, evoking an ashy dermatosis (AD. Paraclinical assessment didn't find any related  disease. Multiple therapy was proposed such as corticosteroids andphototherapy. Evolution was marked by the extension of  lesions in members at five years of follow-up.AD was first described by Ramírez. He called the patients «Los cenicientos». The Spanish term cenicienta means Cinderella, because of this folklore character's close association with ashes from sitting at  home alone by the fireplace. Most cases present  gray–brown macules which are commonly found on the face, arms, neck, and trunk. Histopathologic findings are nonspecific and include vacuolization of the basal layer, pigmentary incontinence and perivascular inflammatory infiltrate. The etiology of AD is unknown. Some authors reported associations with ammonium nitrate, whipworm infestation and HIV seroconversions. Many treatments was proposed such as corticosteroids, dapsone, clofazimine and phototherapy, but the results are not satisfactory. Such as basic research on the pathogenesis and treatment of hypermelanosis continuous, we look for more answers to the questions raised by this case.

  19. Dermatosis profesionales en cuidadores de ancianos

    Directory of Open Access Journals (Sweden)

    Lucía Barchino Ortiz

    2007-06-01

    Full Text Available El progresivo envejecimiento de la población está provocando el desarrollo como grupo profesional de los cuidadores profesionales de ancianos, los auxiliares de geriatría. Puede considerarse un grupo de riesgo para el desarrollo de dermatosis ocupacional debido a las características del trabajo que desempeñan, con una regular exposición a irritantes cutáneos y a trabajo húmedo. Los estudios centrados en la patología cutánea de este colectivo son escasos. Objetivo: El objetivo de este estudio es describir y analizar las características y los diagnósticos clínicos dermatológicos de los pacientes que trabajan como cuidadores de ancianos valorados en nuestro servicio. Material y métodos: Se ha llevado a cabo un estudio observacional retrospectivo de los datos de 41 pacientes cuidadores de ancianos estudiados en nuestro servicio durante un periodo de 11 años. Resultados: Encontramos un predominio total de mujeres. El lugar de afectación más frecuente fueron las manos. Los diagnósticos más frecuentemente establecidos fueron: Eczema endógeno (39,6%, dermatitis de contacto irritativa (DCI (27,1%, dermatitis de contacto alérgica (DCA (12,5%, Sin lesiones (10,4%, urticaria de contacto al látex (4,2% y otros. Conclusiones: El colectivo de cuidadores de ancianos es un grupo en aumento y de gran importancia social. Al desempeñar una labor que implica un trabajo húmedo se debe considerar un grupo de riesgo para el desarrollo de dermatosis profesionales. En nuestro estudio destaca que el diagnóstico de eczema endógeno, representado por la dermatitis atópica, sea el más frecuente, explicándose esto porque una irritación provocada por un trabajo húmedo y la oclusión pueden desencadenar un eczema en el individuo con un fondo atópico, que en otras condiciones se habría mantenido latente. Son necesarios futuros estudios más extensos en este sector profesional.The increasing proportion of elderly citizens worldwide is leading to

  20. Facial dermatosis associated with Demodex: a case-control study*

    Science.gov (United States)

    Zhao, Ya-e; Peng, Yan; Wang, Xiang-lan; Wu, Li-ping; Wang, Mei; Yan, Hu-ling; Xiao, Sheng-xiang

    2011-01-01

    Demodex has been considered to be related with multiple skin disorders, but controversy persists. In this case-control study, a survey was conducted with 860 dermatosis patients aged 12 to 84 years in Xi’an, China to identify the association between facial dermatosis and Demodex. Amongst the patients, 539 suffered from facial dermatosis and 321 suffered from non-facial dermatosis. Demodex mites were sampled and examined using the skin pressurization method. Multivariate regression analysis was applied to analyze the association between facial dermatosis and Demodex infestation, and to identify the risk factors of Demodex infestation. The results showed that total detection rate of Demodex was 43.0%. Patients aged above 30 years had higher odds of Demodex infestation than those under 30 years. Compared to patients with neutral skin, patients with mixed, oily, or dry skin were more likely to be infested with Demodex (odds ratios (ORs) were 2.5, 2.4, and 1.6, respectively). Moreover, Demodex infestation was found to be statistically associated with rosacea (OR=8.1), steroid-induced dermatitis (OR=2.7), seborrheic dermatitis (OR=2.2), and primary irritation dermatitis (OR=2.1). In particular, ORs calculated from the severe infestation (≥5 mites/cm2) rate were significantly higher than those of the total rate. Therefore, we concluded that Demodex is associated with rosacea, steroid-induced dermatitis, seborrheic dermatitis, and primary irritation dermatitis. The rate of severe infestation is found to be more correlated with various dermatosis than the total infestation rate. The risk factors of Demodex infestation, age, and skin types were identified. Our study also suggested that good hygiene practice might reduce the chances of demodicosis and Demodex infestation. PMID:22135150

  1. Facial dermatosis associated with Demodex: a case-control study.

    Science.gov (United States)

    Zhao, Ya-e; Peng, Yan; Wang, Xiang-lan; Wu, Li-ping; Wang, Mei; Yan, Hu-ling; Xiao, Sheng-xiang

    2011-12-01

    Demodex has been considered to be related with multiple skin disorders, but controversy persists. In this case-control study, a survey was conducted with 860 dermatosis patients aged 12 to 84 years in Xi'an, China to identify the association between facial dermatosis and Demodex. Amongst the patients, 539 suffered from facial dermatosis and 321 suffered from non-facial dermatosis. Demodex mites were sampled and examined using the skin pressurization method. Multivariate regression analysis was applied to analyze the association between facial dermatosis and Demodex infestation, and to identify the risk factors of Demodex infestation. The results showed that total detection rate of Demodex was 43.0%. Patients aged above 30 years had higher odds of Demodex infestation than those under 30 years. Compared to patients with neutral skin, patients with mixed, oily, or dry skin were more likely to be infested with Demodex (odds ratios (ORs) were 2.5, 2.4, and 1.6, respectively). Moreover, Demodex infestation was found to be statistically associated with rosacea (OR=8.1), steroid-induced dermatitis (OR=2.7), seborrheic dermatitis (OR=2.2), and primary irritation dermatitis (OR=2.1). In particular, ORs calculated from the severe infestation (≥5 mites/cm(2)) rate were significantly higher than those of the total rate. Therefore, we concluded that Demodex is associated with rosacea, steroid-induced dermatitis, seborrheic dermatitis, and primary irritation dermatitis. The rate of severe infestation is found to be more correlated with various dermatosis than the total infestation rate. The risk factors of Demodex infestation, age, and skin types were identified. Our study also suggested that good hygiene practice might reduce the chances of demodicosis and Demodex infestation.

  2. [Incidence of irritant dermatosis among employees of the shipbuilding industry].

    Science.gov (United States)

    Heise, H; Kühne, G; Kröger, D

    1983-10-01

    Irritant dermatosis is a non-specific reactive change on the skin. In most cases it represents the summated effects induced by various agents. Not only the shortened recovery phases of the skin but also a dispositional factor are important. Such changes, which are relatively common in some vocations but are usually only slight, cannot, as a rule, be regarded as signs of illness. Nevertheless, attention should be drawn to the necessity of intensive skin care and observation of the recovery phases because the frequency of irritant dermatosis can increase with increasing length of employment.

  3. A case of refractory chronic neutrophilic pustular folliculitis treated with adalimumab

    DEFF Research Database (Denmark)

    Sand, Freja Laerke; Thomsen, Simon Francis

    2014-01-01

    Neutrophilic folliculitis is an often overlooked chronic condition characterized by a monomorphic eruption of "sterile" papulopustules. Neutrophilic folliculitis is often refractory to conventional treatment with topical and systemic antibiotics or isotretinoin. We report a case of severe pustular...

  4. Dapsone Therapy for Pustular Psoriasis: Case Series and Review of the Literature.

    Science.gov (United States)

    Sheu, Johanna S; Divito, Sherrie J; Enamandram, Monica; Merola, Joseph F

    2016-01-01

    Pustular psoriasis is an uncommon psoriasis variant, clinically characterized as small sterile pustules on an erythematous base. Evidence for therapy is lacking, and many currently employed systemic therapeutics carry risks of significant side effects, without specifically targeting disease etiology which includes the aggregation of neutrophils. We report therapy with the anti-neutrophil agent dapsone in 5 patients with pustular psoriasis and provide a brief review of the literature. Four patients responded to oral dapsone and 1 to topical dapsone therapy. All 5 patients had previously failed multiple topical and systemic treatments. In 2 cases, oral dapsone allowed for the discontinuation of other systemic agents. One patient stopped oral dapsone due to a side effect of sleep disturbance. Dapsone has a much safer side effect profile and may target the pathophysiology of pustular psoriasis more directly than many other systemic agents. As such, dapsone should be considered for the treatment of patients with pustular psoriasis. © 2015 S. Karger AG, Basel.

  5. [Neutrophilic dermatosis of the hands: acral sweet syndrome?].

    Science.gov (United States)

    Boussofara, L; Gammoudi, R; Ghariani, N; Aounallah, A; Sriha, B; Denguezli, M; Belajouza, C; Nouira, R

    2015-04-01

    Neutrophilic dermatosis may have various clinical presentations but share common histopathological manifestations with an aseptic infiltrate of polymorphonuclears neutrophils. Neutrophilic dermatosis of the hands is a recently described disorder of which we present a case. A 60-year-old woman, without significant past medical history, presented with an acute and painful eruption of both hands with fever. Clinical examination showed erythematous edematous lesions surmounted by pustules that covered the thenar eminences of both hands. The patient was also presenting inflammatory joint pain. Histological findings were predominantly neutrophilic infiltration in the dermis with leukocytoclastic debris. A diagnosis of neutrophilic dermatosis was made and all the lesions disappeared rapidly without relapse under oral prednisone (0.5mg/kg/j). The eruption observed in our patient was clinically and histologically suggestive of neutrophilic dermatosis of the hands, confirming the existence of a homogenous entity which is still debatable if it constitutes a separate entity or a localized variant of Sweet syndrome. Copyright © 2014 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

  6. Psoríase pustulosa da gestação (impetigo herpetiforme: relato de dois casos e revisão da literatura Pustular psoriasis of pregnancy (impetigo herpetiformis: a report of two cases and review of the literature

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    Luna Azulay-Abulafia

    2004-03-01

    Full Text Available Psoríase pustulosa da gravidez é dermatose pustular rara com erupções que se desenvolvem como pústulas estéreis agrupadas na periferia de placas eritematosas da pele. Os sintomas sistêmicos incluem febre alta, astenia, diarréia, delírio, desidratação, tetania e convulsões. O tratamento com corticosteróide sistêmico, antibiótico, reposição de fluidos e eletrólitos é imperativo. Neste relato, são apresentadas duas primigrávidas com 23 e 28 anos que apresentam psoríase pustulosa da gravidez na 24ª e 28ª semana da gestação. Elas foram tratadas e, na primeira paciente, um feto feminino saudável de 2.500 gramas nasceu de parto vaginal, após indução do trabalho de parto na 35ª semana de gestação; na segunda paciente, na 37ª semana de gestação, após se notarem sangramento vaginal moderado e ausência da percepção dos movimentos fetais por 12 horas, um natimorto do sexo feminino, 2.700 gramas, nasceu por indução do parto com prostaglandina.Pustular psoriasis of pregnancy is a rare pustular dermatosis with eruptions that develop in groups of sterile pustules at the periphery of erythematous patches of the skin. Systemic symptoms include high fever, malaise, diarrhea, delirium, dehydration, tetany, and convulsions. Therapy with systemic corticosteroids, antibiotics, replacement of fluid and electrolytes is mandatory. In this report, we present the cases of two primigravidas, 23 and 28 years old, who presented pustular psoriasis of pregnancy at the 24th and 28th week of gestation. They were treated and, in the first case, a healthy 2,500-g female fetus was born vaginally, after labor induction with oxytocin at the 35th week of gestation; in the second patient, at the 37th week of gestation, after a moderate vaginal bleeding and no perception of fetal movements for 12 hours, a stillborn 2,700-g female was born after labor induction with prostaglandin.

  7. Recurrent Malignancy-Associated Atypical Neutrophilic Dermatosis With Noninfectious Shock.

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    Kinser, Kathryn Nicole; Panach, Kamaldeep; Dominguez, Arturo Ricardo

    2017-12-01

    Sweet syndrome (SS) or acute febrile neutrophilic dermatosis presents with the sudden onset of fever, leukocytosis and tender, erythematous, edematous, well-demarcated papules and plaques that histopathologically demonstrate a dense neutrophilic infiltrate. A total of 20% of patients with SS have malignancy-associated disease that can present with bullous or atypical skin lesions that mimic pyoderma gangrenosum, another neutrophilic dermatosis. Both entities exist on a spectrum, and in the context of underlying malignancy, these neutrophilic diseases become less clinically distinct. The literature also describes life-threatening cases of neutrophilic dermatoses that mimic severe sepsis. We present a fatal case of a patient with chronic eosinophilic leukemia with recurrent episodes of malignancy-associated atypical neutrophilic dermatosis characterized by necrotic skin lesions, pulmonary infiltrates and noninfectious shock and we also summarize the clinical presentations of an additional 10 patients reported in the literature. We conducted a PubMed search of articles published up to and in 2015, focusing on the English and Spanish literature with SS cross-referenced with the following search terms: neutrophilic dermatosis, pyoderma gangrenosum, shock, multiorgan failure and systemic inflammatory response syndrome. The articles were reviewed and the patients׳ clinical and laboratory findings were summarized. Cases of atypical neutrophilic dermatosis presenting with noninfectious shock syndrome are likely underrecognized clinically and underreported in the literature. Patients with malignancy-associated atypical neutrophilic dermatoses associated with noninfectious shock syndrome typically have multisystem disease characterized by recurrent episodes and typically have poor prognoses. Copyright © 2017 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

  8. Challenges of biological therapy in patients with pustular psoriasis coexisting with psoriatic arthritis

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    Joanna Narbutt

    2017-04-01

    Full Text Available Introduction . Psoriasis is a chronic inflammatory skin disease affecting approximately 2–3% of the general population. It is a condition with immunological and genetic background, coexisting with psoriatic arthritis in about 25% of cases. Biologic drugs have brought a significant improvement in managing the disease, however they are not approved for the treatment of pustular psoriasis. An increasing number of reports indicate the efficacy of biological drugs in pustular psoriasis. In some patients there are factors responsible for a worse clinical response to biologic therapy. Objective . Presentation of therapeutic difficulties identified in a patient with pustular psoriasis and psoriatic arthritis. Case report . We report a case of a 48-year-old man with generalized pustular psoriasis coexisting with psoriatic arthritis in whom therapy with multiple biologic drugs (adalimumab, infliximab, golimumab, ustekinumab has failed to bring a satisfactory improvement. Conclusions . Further studies are needed to verify the efficacy and pos­sibly approve biological drugs for the treatment of pustular psoriasis. Also, attempts should be made to identify predictors of poorer response to treatment in order to individualize therapy and prevent the loss of efficacy of biologic drugs during prolonged use.

  9. Localized Subcutaneous Acute Febrile Neutrophilic Dermatosis in a Dog

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    Karolin Schoellhorn

    2012-01-01

    Full Text Available A two-year-old spayed female mixed-breed dog was presented with a five-day history of hemorrhagic gastroenteritis and fever. On physical examination, the dog was lethargic and clinically dehydrated. The skin of the entire ventral abdomen extending to both flanks was erythematous, swollen and painful on palpation. Histopathological examination of skin biopsies revealed a severe diffuse neutrophilic dermatitis and panniculitis, resembling the subcutaneous form of Sweet’s syndrome in humans. A large part of the skin lesion developed full-thickness necrosis. After intensive care, three surgical wound debridements and wound adaptations, the wound healed by secondary intention within ten weeks. In the absence of infection of the skin or neoplasia, a diagnosis of neutrophilic dermatosis and panniculitis, resembling the subcutaneous form of acute febrile neutrophilic dermatosis, was made.

  10. Senile gluteal dermatosis: a clinical study of 137 cases.

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    Liu, Han-Nan; Wang, Wen-Jen; Chen, Chih-Chiang; Lee, Ding-Dar; Chang, Yun-Ting

    2014-01-01

    Senile gluteal dermatosis (SGD) is a common genital dermatosis but has gained little attention before. A large-scale clinical study of this disease is lacking. We examined 162 consecutive outpatients with gluteal skin diseases of different causes. Fourteen skin biopsies were performed. Patient's age, gender, body mass index (BMI), way of sitting or lying, treatment response, and underlying systemic diseases were recorded. About 137 (85%) patients could be defined as SGD. These patients, with a mean age of 79.4 ± 40.7 years and a mean BMI of 21.7 ± 10.8, presented with either partial (n = 43, 31%) or full-blown (n = 94, 69%) SGD lesions characterized by the sign of so-called "three corners of a triangle": brownish plaques on the gluteal cleft and each side of the buttocks. Male/female ratio was 130/7. Itching or pain of varying intensity was reported by 50 patients (36%) and 14 patients (10%), respectively. Eighty-six patients (53%) presented with horizontal hyperkeratotic ridges, a characteristic sign of SGD. Most patients spent most of the day sitting but reported no special way of sitting or lying. More than half of patients with SGD claimed no response to topical steroids and/or keratolytics. In comparison with patients with SGD, SGD-free patients were younger (61.3 ± 36 years, P = 0.0005) and heavier (BMI 26.2 ± 15.6, P dermatosis, mostly affecting the thinner elderly. Friction, pressures and long hours sitting seemed to be important factors to trigger this dermatosis. © 2013 The International Society of Dermatology.

  11. [Clinicopathological aspects of terra firma-forme dermatosis].

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    Gusdorf, L; Cribier, B

    2016-01-01

    Terra firma-forme dermatosis was first described in 1987. It is characterized by the appearance in children or adolescents of dirt-like patches despite normal cleansing. The lesions are removed when the skin is rubbed with a 70°C alcohol swab. This largely unknown condition is of uncertain origin but could be due to a keratinisation disorder. Herein we report the case of a 17-year-old male patient who, after seeking the opinions of a number of doctors, consulted in dermatology for multiple pigmented patches on the trunk and limbs that had appeared one year earlier. These lesions had persisted despite appropriate cleansing. He had no history of endocrine disorders and no familial history of pigmentation disorders. A skin biopsy revealed compact orthokeratotic hyperkeratosis resembling a second layer of stratum corneum on top of a normal layer. Very small granules were seen within this layer and PAS staining revealed spores. These skin lesions disappeared when rubbed with an alcohol swab, resulting in a diagnosis of terra firma-forme dermatosis. Where a diagnosis of terra firma-forme dermatosis is suspected, confirmation is easy to obtain using an alcohol swab. Nevertheless, the disease is not familiar to dermatologists. The most common differential diagnoses are acanthosis nigricans, reticulate and confluent papillomatosis, and Dowling-Degos disease. Their histopathological appearances are very different and skin biopsy can be useful for diagnosis. These entities belong to a group of disorders involving abnormal keratinisation and pigmentation. Anatomoclinical correlation is essential for optimal management. The appearance of the stratum corneum may play an important role in the diagnosis of terra firma-forme dermatosis. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  12. The case of annular type of pustular psoriasis in a child

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    Karakaeva A.V.

    2012-06-01

    Full Text Available

    This study presents the clinical case of pustular psoriasis in a child. This type of disease is a rare variant of derma-toses in childhood. Due to abnormality of rash localization a differential diagnosis was applied with contact dermatitis, staphylococcus impetigo and rubromycosis.

  13. Pustular Palmoplantar Psoriasis Successfully Treated with Nb-UVB Monochromatic Excimer Light: A Case-Report

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    Serena Gianfaldoni

    2017-07-01

    Full Text Available Barber’s palmoplantar pustulosis (PPP is a form of localised pustular psoriasis, affecting the palmar and plantar surfaces. It is a chronic disease, with a deep impact on the patients’ quality of life. The Authors discuss a case of Baber Psoriasis successfully treated with monochromatic excimer light.

  14. Acute Generalized Erythrodermic Pustular Psoriasis Associated with Bupropion/Naltrexone (Contrave®).

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    Singh, Priyanka A; Cassel, Kerry P; Moscati, Ronald M; Eckersley, David

    2017-04-01

    We report a case of erythrodermic pustular psoriasis associated with initiation of bupropion/naltrexone (Contrave®; Orexigen Therapeutics, La Jolla, CA) in a patient with no history of psoriasis. A 55-year-old woman was transferred to our tertiary medical center from a community hospital for possible Stevens-Johnson syndrome 3 weeks after initiation of bupropion/naltrexone. The patient was admitted to the burn unit for wound treatment and hydration. She received intravenous cyclosporine during the admission that resulted in acute kidney injury and the therapy was discontinued. The skin biopsy ruled out Stevens-Johnson syndrome and was more consistent with generalized pustular psoriasis. After discharge, the patient followed up with her dermatologist. She was diagnosed with acute generalized and erythrodermic psoriasis and the patient was restarted on cyclosporine 100 mg twice a day. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Few case reports of bupropion-induced generalized pustular psoriasis and erythrodermic psoriasis in patients with a history of psoriasis have been reported. To our knowledge, acute generalized erythrodermic pustular psoriasis associated with bupropion/naltrexone has not been reported in a patient without history of psoriasis. Due to increases in obesity and increases in prescribing of bupropion/naltrexone SR, health care providers should be aware of this possible severe adverse reaction. Published by Elsevier Inc.

  15. Propionic acidemia manifesting with low isoleucine generalized exfoliative dermatosis.

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    Lane, Tanda N; Spraker, Mary K; Parker, Sareeta S

    2007-01-01

    We describe an infant with propionic acidemia who developed a generalized exfoliative eruption. Preceding the eruption, he was on an amino acid restricted formula. Within days of liberalizing his restricted diet, the eruption resolved completely. A similar dermatitis has been reported in infants with inborn errors of metabolism who were on amino acid modified formulas. However, in most instances, the eruption was predominantly limited to the periorificial regions. Most critical in the etiology of cutaneous eruptions in these patients is low serum isoleucine. Amino acid malnutrition should be considered in the differential diagnosis of generalized exfoliative dermatosis in an infant. Supplementation with isoleucine-containing dietary proteins results in rapid clinical resolution.

  16. Terra firma-forme dermatosis: a retrospective review of 31 patients.

    Science.gov (United States)

    Berk, David R

    2012-01-01

    Terra firma-forme dermatosis is an idiopathic condition characterized by acquired, dirtlike plaques despite normal hygiene. A diagnosis can be reached by removing lesions with gentle alcohol swabbing. Although Terra firma-forme dermatosis was first described more than 20 years ago and is thought to be not uncommon in clinical practice, it has never been systematically studied. There are few publications about this condition, including no case series of more than six patients. In particular, little is known about the incidence, peak age groups, and most common locations of Terra firma-forme dermatosis. A retrospective review was conducted to identify cases of Terra firma-forme dermatosis in a single-provider practice consisting of 55% pediatric and 45% adult patients. Thirty-one patients with Terra firma-forme dermatosis were identified, including 10 who presented with Terra firma-forme dermatosis as their primary concern. Only two patients were older than 17 years. The median duration of lesions was 4 months. The most common lesion locations were the neck, ankles, and face. Before presenting to the dermatology clinic, three patients had undergone endocrine evaluations, and four had been prescribed topical corticosteroids. Terra firma-forme dermatosis is relatively common and most often occurs in children on the neck or posterior malleolus. This series exemplifies the importance of recognizing Terra firma-forme dermatosis so as to provide rapid relief for patients and avoid unnecessary tests and treatments. © 2011 Wiley Periodicals, Inc.

  17. Clinical Relevance of Autoantibodies in Patients with Autoimmune Bullous Dermatosis

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    Lilla Mihályi

    2012-01-01

    Full Text Available The authors present their experience related to the diagnosis, treatment, and followup of 431 patients with bullous pemphigoid, 14 patients with juvenile bullous pemphigoid, and 273 patients with pemphigus. The detection of autoantibodies plays an outstanding role in the diagnosis and differential diagnosis. Paraneoplastic pemphigoid is suggested to be a distinct entity from the group of bullous pemphigoid in view of the linear C3 deposits along the basement membrane of the perilesional skin and the “ladder” configuration of autoantibodies demonstrated by western blot analysis. It is proposed that IgA pemphigoid should be differentiated from the linear IgA dermatoses. Immunosuppressive therapy is recommended in which the maintenance dose of corticosteroid is administered every second day, thereby reducing the side effects of the corticosteroids. Following the detection of IgA antibodies (IgA pemphigoid, linear IgA bullous dermatosis, and IgA pemphigus, diamino diphenyl sulfone (dapsone therapy is preferred alone or in combination. The clinical relevance of autoantibodies in patients with autoimmune bullous dermatosis is stressed.

  18. Feline familial pedal eosinophilic dermatosis in two littermates

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    Charline Pressanti

    2015-04-01

    Full Text Available In cats, the most common eosinophilic dermatoses are feline miliary dermatitis and eosinophilic granuloma complex. The most commonly identified underlying cause is a hypersensitivity reaction. Few cases of familial forms of eosinophilic dermatoses are reported in the literature. Two young adult cats from the same litter presented 2 years apart with a severe and chronic fluid or tissue infiltration of the distal part of several limbs. Lesions started on the forelegs and developed on the other limbs. Cytological and histopathological examinations showed lesions consistent with an atypical form of feline eosinophilic dermatosis associated with secondary bacterial infection. In both cats, antibiotics combined with immunosuppressive treatment partially improved the lesions, which continued to progress on a waxing and waning course, even in the absence of treatment. Allergy work-up did not permit the identification of an underlying allergic triggering factor. The severity of the lesions, the unusual presentation and the unsatisfactory response to immunosuppressive therapy in two feline littermates suggested a genetic form of eosinophilic dermatosis.

  19. Acral manifestations of Sweet syndrome (neutrophilic dermatosis of the hands).

    Science.gov (United States)

    Wolf, Ronni; Tüzün, Yalçın

    Neutrophilic dermatosis of the hand (NDH) is a rare localized variant of the syndrome, originally described two decades ago by Strutton et al. The lesions of NDH and Sweet syndrome are similar, as indicated in the first report of NDH. Both diagnoses are characterized by an acute onset of fever, leukocytosis, and tender, erythematous infiltrated plaques. There are also bullae and ulceration in NDH, in contrast to Sweet syndrome, in which bullae are quite uncommon, especially at the early stages. Similar to Sweet syndrome, the majority of NDH patients are women (69%). Patients with NDH present with fever, peripheral neutrophilia, leukocytosis, and/or an elevated erythrocyte sedimentation rate or C-reactive protein level, but at a significantly lower rate than those in Sweet syndrome (33%). Similar to Sweet syndrome, NDH has been associated with the following conditions: Malignancies (particularly hematological [21%], most common of which is acute myelogenous leukemia, but many other malignancies as well), inflammatory bowel disease (19%), medication and vaccination-related eruptions, bacterial and viral infections, rheumatologic diseases, and others. The clues to the diagnosis of NDH are the same as for Sweet syndrome. Awareness of this diagnosis is important not only to avoid unnecessary medical and surgical therapy and to expediently initiate the administration of steroids for this highly responsive dermatosis, but also to conduct an appropriate workup to exclude associated diseases, especially malignancies. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Non-invasive methods to establish the diagnosis of terra firma-forme dermatosis: The SMART (Skin Modified by Alcohol Rubbing Test) evaluation and dermoscopy.

    Science.gov (United States)

    Greywal, Tanya; Cohen, Philip R

    2016-06-15

    Terra firma-forme dermatosis may mimic a variety of hyper pigmented dermatoses.  The diagnosis can be characterized using dermoscopy and confirmed with the SMART (Skin Modified by Alcohol Rubbing Test) evaluation.  When terra firma-forme dermatosis (Duncan's dirty dermatosis) is clinically suspected, clearance of the dermatosis follows rubbing the affected skin with 70% isopropyl alcohol.

  1. Erythema Dyschromicum Perstans: Identical to Ashy Dermatosis or Not

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    Takafumi Numata

    2015-07-01

    Full Text Available Erythema dyschromicum perstans (EDP and ashy dermatosis (AD are pigmentary disorders of unknown etiology. EDP is usually considered to be identical to AD; however, a new clinical classification for EDP was proposed in the recent literature. Herein, we report a typical case of EDP observed in an African-American man. Interestingly, the late skin lesions in this case fit the criteria of AD as well. While there appear to be a few clinical cases that can be diagnosed as both EDP and AD based on the clinical course, the preponderance of the evidence in the published reports of EDP and AD and the clinical findings reported here strongly suggest that they are two distinct entities in terms of the extent of the inflammation, albeit on the same spectrum of pigment disorders.

  2. Acquired perforating dermatosis: a report of 8 cases.

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    González-Lara, L; Gómez-Bernal, S; Vázquez-López, F; Vivanco-Allende, B

    2014-01-01

    Acquired perforating dermatosis (APD) is an uncommon disease characterized by lesions exhibiting transepidermal elimination of collagen or elastic fibers. APD affects adults and is associated with systemic diseases, mainly diabetes mellitus and renal failure. We present 8 cases of APD. Seven patients had concomitant diabetes mellitus with or without chronic renal failure, and 1 had alcoholic cirrhosis. In the patients with chronic renal failure, the onset of APD coincided with transient worsening of renal function. The mean increase in creatinine concentrations above baseline was 1.14mg/dL. Acute deterioration of renal function may be involved in APD. Further studies are needed to investigate this association. Copyright © 2013 Elsevier España, S.L. y AEDV. All rights reserved.

  3. Erythema Dyschromicum Perstans: Identical to Ashy Dermatosis or Not?

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    Numata, Takafumi; Harada, Kazutoshi; Tsuboi, Ryoji; Mitsuhashi, Yoshihiko

    2015-01-01

    Erythema dyschromicum perstans (EDP) and ashy dermatosis (AD) are pigmentary disorders of unknown etiology. EDP is usually considered to be identical to AD; however, a new clinical classification for EDP was proposed in the recent literature. Herein, we report a typical case of EDP observed in an African-American man. Interestingly, the late skin lesions in this case fit the criteria of AD as well. While there appear to be a few clinical cases that can be diagnosed as both EDP and AD based on the clinical course, the preponderance of the evidence in the published reports of EDP and AD and the clinical findings reported here strongly suggest that they are two distinct entities in terms of the extent of the inflammation, albeit on the same spectrum of pigment disorders.

  4. Palmoplantar pustular psoriasis (PPPP) is characterized by activation of the IL-17A pathway.

    Science.gov (United States)

    Bissonnette, Robert; Fuentes-Duculan, Judilyn; Mashiko, Shunya; Li, Xuan; Bonifacio, Kathleen M; Cueto, Inna; Suárez-Fariñas, Mayte; Maari, Catherine; Bolduc, Chantal; Nigen, Simon; Sarfati, Marika; Krueger, James G

    2017-01-01

    Palmoplantar pustular psoriasis (PPPP) is a variant of psoriasis, which has significant negative impact on quality of life. The cellular and molecular inflammatory pathways involved in PPPP have not been well studied. Study the expression of cytokines and chemokines involved in the IL-17/IL-23 axis in palmoplantar pustular psoriasis and other difficult to treat psoriasis areas (palms, scalp, elbows and lower legs). Skin biopsies were performed on a total of 80 patients with PPPP, non-pustular palmoplantar psoriasis (NPPPP), or psoriasis located on elbows, knees and scalp as well as 10 healthy subjects. RT-PCR, immunohistochemistry and flow cytometry on cells extracted from skin biopsies were used to compare PPPP to other forms of psoriasis. There was a significant (ppsoriasis. The proportion of IL-22(+) but not IL-17A(+) mast cells was higher in PPPP as compared to NPPPP (p<0.05). These results suggest that the IL-17A pathway may play a more important role in PPPP than in NPPPP. Copyright © 2016. Published by Elsevier Ireland Ltd.

  5. Clinical therapeutic effect of intense pulse light PhotoDerm for vascular dermatosis

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    Qiu, Li-Jun; Xu, Li-Wei; Li, Ying-Yi; Yang, Ji-Qing; Qi, Jia-Xue

    2008-12-01

    Objective: To observe the clinical therapeutic effect of intense pulsed light PhotoDerm (IPL PhotoDerm) for vascular dermatosis and analysis the possible factors affecting the therapeutic effect. Methods: Treat all blank kinds of vascular dermatosis 85 cases with IPL PhotoDerm, observe the therapeutic effect and no obvious side-effects of vascular dermatosis. Results: The cure rate of telangiectasis, arterial spider nevus, strawberry nevus, avermrus uemongioma and nevus flammeus with IPL PhotoDerm is respective 76.5%, 91.7%, 88.9%, 27.8%, 15%, and the cure rate in three times is respective 35.3%, 91.7%, 66.7%, 5.6% and 5%. 6 eases appear pigmentation, pigment subsidence or atrophic scar. Conclusion: The therapeutic effect of vascular dermatosis with IPL PhotoDerm is satisfying, and the no obvious side-effects is less.

  6. A Case of Terra Firma-Forme Dermatosis Treated with Salicylic Acid Alcohol Peeling.

    Science.gov (United States)

    Chun, Sin Wook; Lee, Suk Young; Kim, Jong Baik; Choi, Hoo Min; Ro, Byung In; Cho, Han Kyoung

    2017-02-01

    Terra firma-forme dermatosis (TFFD) is a bizarre, acquired and idiopathic dermatosis that etiology has still not been fully defined. It is characterized by the presence of asymptomatic, brownish dirt-like lesion maybe due to disorder of keratinization. These lesions cannot be removed with ordinary cleansing. Therefore, TFFD can be differentiated from dermatosis neglecta. Patient was a 17-year-old man with brownish lesions on his face for 1 month. The patient had a history of regular washing habit with soap and water. The lesions were asymptomatic however due to cosmetic reasons, the patient wanted to treat his skin lesions. Punch biopsy revealed hyperkeratosis and fungal spore are in stratum corneum. Salicylic acid peeling with alcohol base was performed on the patient's face. The skin lesions disappeared completely on gentle swabbing with peeling. In this point, the diagnosis of TFFD could be considered. Since, this disease can be confused with dermatosis neglecta, we report this case with literature review.

  7. Niacin metabolism and indoleamine 2,3-dioxygenase activation in malnourished patients with flaky paint dermatosis.

    Science.gov (United States)

    Maltos, André Luiz; Portari, Guilherme Vannucchi; Moraes, Giselle Vanessa; Monteiro, Marina Casteli Rodrigues; Vannucchi, Helio; da Cunha, Daniel Ferreira

    2015-06-01

    Flaky paint dermatosis, characterized by extensive, often bilateral areas of flaking and pigmentation, mostly in sun unexposed areas is considered a feature of kwashiorkor in both children and adults, and must be differentiated from other dermatosis, including chapped and xerotica skin, and pellagra. In this case series we provide evidence that malnourished patients with flaky paint dermatosis and infection/inflammation shown laboratory data suggestive of indoleamine 2,3-dioxygenase (IDO) activation, besides decreased urinary excretion of N1-methylnicotinamide (N1 MN), a marker of pellagra. We study nine adult patients showing flaky paint dermatosis and clinical features of infection or inflammation, and increased serum C-reactive protein, characteristic of the presence of acute phase response syndrome. As a group, they had low or deficient urinary N1 MN excretion (0.52 ± 0.39 mg/g creatinine) compatible with pellagra. They also showed low serum tryptophan levels (dermatosis showed laboratory data suggestive of IDO activation, besides decreased N1 MN urinary excretion. Taken together, the data support the idea that flaky paint dermatosis could be a skin manifestation of niacin deficiency. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. Nursing diagnoses in patients with immune-bullous dermatosis

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    Euzeli da Silva Brandão

    Full Text Available ABSTRACT Objective: identify nursing diagnoses in patients with immune-bullous dermatosis. Method: a quantitative and descriptive research, carried out in three institutions located in Rio de Janeiro and Mato Grosso do Sul, Brazil, using the Client Assessment Protocol in Dermatology during a nursing consultation. Simple descriptive statistics was used for data analysis. Results: 14 subjects participated in the study, nine with a diagnosis of pemphigus vulgaris, pemphigus two and three of bullous pemphigoid. The age ranged between 27 and 82 years, predominantly females (11. 14 nursing diagnoses were discussed and identified from a clinical rationale in all study participants, representing the most common human responses in this sample. The application of the Assessment Protocol in Dermatology facilitated the comprehensive assessment, in addition to providing the identification of diagnostics according to the North American Nursing Diagnosis Association International. Conclusion: the nursing diagnoses presented confirm the necessity of interdisciplinary work during the care for this clientele. For better description of the phenomena related to the client in question, it is suggested the inclusion of two risk factors related in three diagnoses of this taxonomy. It is worth noting the contribution of the findings for the care, education and research in nursing in dermatology.

  9. Prevalence of self-reported hand dermatosis in upper secondary school pupils.

    Science.gov (United States)

    Yngveson, M; Svensson, A; Isacsson, A

    1998-09-01

    The purpose of the present study was to estimate the prevalence of self-reported hand dermatosis among upper secondary school pupils. All pupils in grades 1 and 3 from the four upper secondary schools in Växjö, southern Sweden, were invited to participate in the study. A previously validated questionnaire was used. Of the 2609 invited pupils, 2572 (98.6%) responded to the questionnaire. The point prevalence of self-reported hand dermatosis was 4.2% (95% CI, 3.4-4.9%) with no significant differences between gender and grades. The overall one-year prevalence of self-reported hand dermatosis was 10.0% (95% CI, 8.8-11.1%), i.e. the corresponding figures for males were 7.3% (95% CI, 5.9-8.8%) and for females 12.5% (95% CI, 10.6-14.6%). There were significant gender differences in grade 1 (p hotel and restaurant course had the highest one-year prevalence in grade 3. It is concluded that the high point and one-year prevalence of hand dermatosis among upper secondary school pupils merits long-term prospective study in order to address the question of which aetiological or trigger factors are most important in the development of hand dermatosis in a population.

  10. Foliculitis pustulosa eosinofílica: Enfermedad de Ofuji Eosinophilic pustular folliculitis: Ofuji's disease

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    R E Achenbach

    2007-12-01

    Full Text Available Presentamos un caso de la denominada foliculitis pustulosa eosinofílica o enfermedad de Ofuji, sin eosinofilia periférica ni inmunosupresión asociada. El cuadro respondió inicialmente bien a la dapsona, pero debido a un aumento de enzimas hepáticas y bilirrubina se rotó a terapia tópica con clobetasol y pimecrolimus, con buena respuesta. Efectuamos una revisión del cuadro enfatizando que el mismo constituye una inflamación del epitelio infundibular y no folicular constituyendo un patrón de respuesta a múltiples causas, algunas o la mayoría no bien conocidas.A case of the so called eosinophilic pustular folliculitis or Ofuji´s disease, without blood eosinophilia nor immunosuppression is reported. The patient responded at first well to Dapsone, but an increase of the hepatic enzymes and bilirubin was detected and only topical therapy with clobetazol and pimecrolimus was carried out with a good response. A revision of the disease with emphasis in the concept of infundibulitis rather than folliculitis was made. The eosinophilic pustular folliculitis is a pattern of response to multifactorial, mostly unknown, causes and not a single disease.

  11. IgA Pemphigus in a Child – a Case Report

    Directory of Open Access Journals (Sweden)

    Lekić Branislav

    2017-03-01

    Full Text Available IgA pemphigus (IGAP is a rare autoimmune bullous disease characterized by IgA deposits on keratinocyte cell surfaces. The IGAP is classified into: 1 subcorneal pustular dermatosis (SPD type, and 2 intraepidermal neutrophilic (IEN IgA dermatosis type. So far, only 9 children with IGAP have been described in the literature, of whom only 3 with SPD type. We report a 3-year-old boy with SPD type of IGAP. Clinically, he presented with pruritic vesicles, pustules and erosions on the face, trunk, groin area, and extremities. Histopathology showed subcorneal pustules containing a few acantholytic cells. Direct immunofluorescence (DIF test of Tzanck smear showed intercellular IgA deposits on the surface of the groups of epidermal cells. Oral dapsone and prednisone induced remission after two weeks; the treatment was discontinued 11 months later, and complete remission was achieved during 19 months without any treatment. Direct immunofluorescence of Tzanck smear is a simple, sensitive, rapid and non-aggressive test, very suitable for the diagnosis of IGAP in children.

  12. Nursing diagnoses in patients with immune-bullous dermatosis.

    Science.gov (United States)

    Brandão, Euzeli da Silva; Santos, Iraci Dos; Lanzillotti, Regina Serrão; Ferreira, Adriano Menis; Gamba, Mônica Antar; Azulay-Abulafia, Luna

    2016-08-15

    identify nursing diagnoses in patients with immune-bullous dermatosis. a quantitative and descriptive research, carried out in three institutions located in Rio de Janeiro and Mato Grosso do Sul, Brazil, using the Client Assessment Protocol in Dermatology during a nursing consultation. Simple descriptive statistics was used for data analysis. 14 subjects participated in the study, nine with a diagnosis of pemphigus vulgaris, pemphigus two and three of bullous pemphigoid. The age ranged between 27 and 82 years, predominantly females (11). 14 nursing diagnoses were discussed and identified from a clinical rationale in all study participants, representing the most common human responses in this sample. The application of the Assessment Protocol in Dermatology facilitated the comprehensive assessment, in addition to providing the identification of diagnostics according to the North American Nursing Diagnosis Association International. the nursing diagnoses presented confirm the necessity of interdisciplinary work during the care for this clientele. For better description of the phenomena related to the client in question, it is suggested the inclusion of two risk factors related in three diagnoses of this taxonomy. It is worth noting the contribution of the findings for the care, education and research in nursing in dermatology. identificar diagnósticos de enfermagem em clientes com dermatoses imunobolhosas. pesquisa quantitativa e descritiva, realizada em três instituições localizadas no Rio de Janeiro e no Mato Grosso do Sul-Brasil, aplicando o Protocolo de Avaliação do Cliente em Dermatologia, durante consulta de enfermagem. Utilizou-se a estatística descritiva simples para análise dos dados. participaram do estudo 14 sujeitos, nove com diagnóstico médico de pênfigo vulgar, dois de foliáceo e três de penfigoide bolhoso. A idade variou entre 27 e 82 anos, predominando 11 pessoas do sexo feminino. Foram discutidos 14 diagnósticos de enfermagem

  13. Linear IgA bullous dermatosis in a patient with renal cell carcinoma

    NARCIS (Netherlands)

    Van der Waal, RIF; Van de Scheur, MR; Pas, HH; Jonkman, MF; Van Groeningen, CJ; Nieboer, C; Starink, TM

    Linear IgA bullous dermatosis (LABD) is an autoimmune subepidermal bullous disease with heterogeneous clinical manifestations, characterized by linear deposition of IgA along the epidermal basement membrane zone. We report a patient with a metastasized renal cell carcinoma who developed an extensive

  14. Terra Firma-Forme Dermatosis in Singaporean Patients: The "Alcohol Wipe" Sign.

    Science.gov (United States)

    Oh, Choon Chiat; Oon, Hazel H; Ng, See Ket; Tee, Shang Ian; Jhingan, Anjali; Chong, Wei-Sheng

    2016-01-01

    The term terra firma-forme dermatosis arises from the Latin phrase terra firma , meaning dry land (dirt), thus implying dirt-like dermatosis. The authors highlight five cases of patients with terra firma-forme dermatosis presenting to our dermatology center between 2012 and 2013. All patients presented to the dermatologist for persistent reticulated brown patches on the skin. These patients ranged in age from 6 to 22 years. All patients had tried various cleansing soaps and agents but were unable to remove the patches. The condition was cosmetically unacceptable to the patients and parents. Clinically, these patients had reticulated brown patches. Rubbing 70% isopropyl alcohol wipes on the affected areas demonstrated clearance of the brown pigmented patches in all cases. The diagnosis of terra firma-forme dermatosis (TFFD) was confirmed by forceful rubbing with a gauze pad immersed in 70% isopropyl alcohol or ethyl alcohol. Patients should be reassured about the benign nature of TFFD and educated about the cleaning procedure. Recognition of this condition can assist physicians in making a diagnosis and therapy with a simple alcohol wipe, preventing further unnecessary tests for patients.

  15. Eosinophilic pustular folliculitis: the transition in sex differences and interracial characteristics between 1965 and 2013.

    Science.gov (United States)

    Nomura, Takashi; Katoh, Mayumi; Yamamoto, Yosuke; Kabashima, Kenji; Miyachi, Yoshiki

    2015-04-01

    Eosinophilic pustular folliculitis (EPF) is characterized by a non-infectious infiltration of eosinophils in the hair follicles. It has three variants: (i) classic EPF; (ii) immunosuppression-associated EPF, which herein is subdivided into HIV-associated (IS/HIV) and non-HIV-associated (IS/non-HIV); and (iii) infancy-associated EPF (I-EPF). The rarity of EPF has hindered our understanding of this entity. To examine the characteristics of EPF, with respect to age, sex, race, and chronology, published in case reports to date, we queried PubMed using the following terms: ("eosinophilic pustular folliculitis" [All Fields] OR "eosinophilic folliculitis" [All Fields]) AND ("1965/1/1" [PDAT]: "2013/12/31" [PDAT]). Additional Japanese cases were collected from Igaku Chuo Zasshi through Ichushi-Web, JDream III, and secondhand quotations from domestic periodicals published in Japan. Proceedings were excluded. The PubMed search produced 275 citations containing 358 cases of EPF (224 men, 132 women, and two of unspecified sex); these cases involved classic EPF (101 Japanese and 81 non-Japanese), IS/HIV (4 Japanese and 85 non-Japanese), IS/non-HIV (4 Japanese and 20 non-Japanese), and I-EPF (4 Japanese and 59 non-Japanese). Ichushi generated an additional 148 citations containing 207 cases of Japanese (148 men and 59 women), which included cases of classic EPF (181 cases), IS/HIV (14 cases), IS/non-HIV (9 cases), and I-EPF (3 cases). There was no sex difference in the classic EPF cases reported between 2003 and 2013, whereas IS/HIV, IS/non-HIV, and I-EPF were predominated by men. There is room for reconsideration of sex differences, particularly with regard to classic EPF. The rarity and specificity of I-EPF in Japan may reflect a state of uncertainty about this entity. © 2015 Japanese Dermatological Association.

  16. Generalized pustular psoriasis in a 92-year-old man with a homozygous nonsense mutation in IL36RN.

    Science.gov (United States)

    Ueda, Yoshitaka; Komine, Mayumi; Kamiya, Koji; Tsuda, Hidetoshi; Maekawa, Takeo; Murata, Satoru; Ohtsuki, Mamitaro

    2017-12-07

    A 92-year-old man developed an erythematous eruption on the trunk and extremities with numerous pustules accompanied by fever. He had never experienced pustular eruption or been diagnosed with psoriasis previously. Skin biopsy revealed Kogoj's spongiform pustule, and he was diagnosed with generalized pustular psoriasis (GPP). Genomic DNA was extracted from his peripheral blood and the sequence of IL36RN gene was analyzed, which revealed a p.Arg10X homozygous mutation. Several cases of elderly-onset GPP have been reported, however, this is the oldest case of GPP. The existence of splice variants of IL36RN was suspected, but we could not detect any splice variants of IL36RN in this case or in a healthy control from peripheral blood samples. © 2017 Japanese Dermatological Association.

  17. Generalized pustular psoriasis in infant with heterozygous mutation in the IL36RN gene successfully treated with infliximab

    DEFF Research Database (Denmark)

    Glerup, Mia; Herlin, Troels; Veirum, Jens Erik

    or DITRA genetic testing for IL1RN and IL36RN gene mutations was initiated. The girl was found to be heterozygous for a mutation in the IL36RN gene (exon 5, c 338C>T p Ser113Leu) whereas the IL1RN gene (mutated in DIRA patients) was normal. Additionally, a heterozygous mutation in the NLRP3 gene was also......Generalized pustular psoriasis in infant with heterozygous mutation in the IL36RN gene successfully treated with infliximab.M. Glerup1, J.E. Veirum1, L. Iversen2, M. Christiansen3, T. Herlin1.Departments of 1Pediatrics and 2Dermatology, and 3Clinical Immunology, Aarhus University Hospital, Denmark...... Background: Homozygous missense mutation in the IL36RN gene resulting in deficiency of interleukin-36-receptor antagonist (DITRA) is phenotypically presented as severe generalized pustular psoriasis starting in early childhood. Compound heterozygous cases have been described with the same DITRA phenotype...

  18. Dermatosis neglecta: simulación, una realidad. A propósito de un caso Dermatosis neglecta: simulation, a reality. A propos of a case

    Directory of Open Access Journals (Sweden)

    JA Pineda-Pineda

    Full Text Available La dermatosis neglecta es una patología poco conocida, causada por la falta de higiene, generalmente secundaria al temor de agravar algún problema subyacente de piel como el acné, cicatrices postquirúrgicas, zonas que han recibido radioterapia, cicatrices queloides entre otras, presentando placas cubiertas con costras gruesas, con escamas oleosas e hiperpigmentación, que desaparecen al lavado o limpieza enérgica con alcohol o acetona, quedando la piel sana. Presentamos el caso de un paciente de 20 años de edad, proveniente de la consulta dermatológica de la Liga contra el Cáncer de San Pedro Sula, Honduras, quien se presenta en primera instancia por un cuadro de acné para el que se lo medica con peróxido de benzoilo y protector solar. Acude dos meses después con elementos costrosos gruesos adherentes y oleosos acompañados de eritema e hiperpigmentación, los que desaparecen con la limpieza profunda con alcohol, quedando la piel totalmente limpia. Al interrogatorio refiere que no se había lavado la cara para no empeorar su cuadro de acné. Se hace entonces el diagnóstico de dermatosis neglecta.The neglecta dermatosis is an almost unknown pathology. It is caused of lack of hygienic measures, generally subsequent to the pain to increase an existent trouble on the skin (ex: acne, postsurgical scars, radiotherapy, scars, keloids, etc presenting plates covered with thick crusts, with oily flakes and hyper keratosis pigmentation, which disappears with energetic washing or cleaning with alcohol or acetone, leaving a healthy skin. We present the case of a 20 years old patient who visited the dermatological department of the La Liga Contra el Cancer in San Pedro Sula, Honduras. The first time that he visited the doctor´s office was for acne and he was prescribed with benzoyl peroxide and sunscreen. Two months later the patient came with his skin hyper pigmented and covered with thick oily crusts which disappeared with energetic cleansing

  19. Dermatosis profesional por resina epoxi: Presentación de un caso clínico Professional dermatosis for epoxy resin: A clinical case report

    Directory of Open Access Journals (Sweden)

    S Gaviola

    2008-06-01

    Full Text Available Mostramos un caso de dermatosis profesional originado por plásticos (resinas epoxi y la importancia de la detección precoz. Las resinas epoxi son de gran utilización en todo tipo de industrias (artes graficas, construcción, electrónica, componentes de prótesis traumatológicas, prótesis odontológicas, etc. y sus componentes pueden ser causa de dermatitis de contacto irritativa y por sensibilización.We describe a case of professional dermatosis caused by exposition to plastic products (epoxy resin and importance of early detection. The epoxy resins are widely used in all types of industries (graphics arts, construction, electronics, traumathological and odontological prothesis, etc. and their components may be the cause of contact dermatitis and sensitivity. Risk factors at work with epoxy resins are present during the production base resins, hardening agents, plasticizers and dilutants increase the risk of exposition at work. This requires preventive measures and early diagnosis.

  20. Pemphigoid gestationis – a rare dermatosis of the prenatal period. Case report

    Directory of Open Access Journals (Sweden)

    Marcin M. Skutil

    2016-06-01

    Full Text Available Introduction. Most skin lesions during pregnancy are associated with hormonal changes. Pemphigoid (herpes gestationis (PG is a significant dermatosis of the prenatal period reflecting pathology affecting the mother and fetus. Objective. The aim of the study was to present a PG case, a rare pregnancy dermatosis with a severe clinical outcome during the postpartum period. Case report . We present a case of a patient in whom skin lesions with tense blisters occurred at the 40th week of pregnancy. Herpes gestationis – a rare skin disease – was diagnosed based on the clinical picture. During the first days of puerperium, because of an aggressive disease course, the patient was transferred to a reference centre for skin disease treatment. She was given corticosteroid therapy, which brought the expected results. Conclusions. Pemphigoid gestationis is a rare and serious dermatosis of the prenatal period. Although the treatment of such diseases is the dermatologists’ task, obstetricians are responsible for diagnosis and for fetal monitoring considering placental pathology.

  1. Juvenile generalized pustular psoriasis with IL36RN mutation treated with short-term infliximab.

    Science.gov (United States)

    Pan, Junwei; Qiu, Li; Xiao, Ting; Chen, Hong-Duo

    2016-05-01

    A 8-year-old Chinese boy with generalized pustular psoriasis (GPP) refractory to cyclosporine and methylprednisolone was treated successfully with two infusions of infliximab 3.3 mg/kg. He remained in remission for 21 months. Direct sequencing of IL36RN gene showed a homozygous mutation, c.115 + 6T>C. Juvenile GPP is a rare severe form of psoriasis occasionally associated with life-threatening complications. Like acitretin, cyclosporine and methotrexate, infliximab has been reported to be effective for juvenile GPP in case reports. However, there is a lack of data in the optimal treatment course of infliximab for juvenile GPP. Prolonged administration of these medications may cause toxic or fatal complications. We suggest that short-term infliximab regimen should be recommended as a choice for acute juvenile GPP refractory to traditional systemic therapies. WBC count and CRP are sensitive parameters to reflect the disease activity and evaluate the effectiveness of treatment. Monitoring CD4 T lymphocyte count, preventing and correcting CD4 lymphocytopenia are important in the treatment course of juvenile GPP. © 2015 Wiley Periodicals, Inc.

  2. Sweet's syndrome – a comprehensive review of an acute febrile neutrophilic dermatosis

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    Cohen Philip R

    2007-07-01

    Full Text Available Abstract Sweet's syndrome (the eponym for acute febrile neutrophilic dermatosis is characterized by a constellation of clinical symptoms, physical features, and pathologic findings which include fever, neutrophilia, tender erythematous skin lesions (papules, nodules, and plaques, and a diffuse infiltrate consisting predominantly of mature neutrophils that are typically located in the upper dermis. Several hundreds cases of Sweet's syndrome have been published. Sweet's syndrome presents in three clinical settings: classical (or idiopathic, malignancy-associated, and drug-induced. Classical Sweet's syndrome (CSS usually presents in women between the age of 30 to 50 years, it is often preceded by an upper respiratory tract infection and may be associated with inflammatory bowel disease and pregnancy. Approximately one-third of patients with CSS experience recurrence of the dermatosis. The malignancy-associated Sweet's syndrome (MASS can occur as a paraneoplastic syndrome in patients with an established cancer or individuals whose Sweet's syndrome-related hematologic dyscrasia or solid tumor was previously undiscovered; MASS is most commonly related to acute myelogenous leukemia. The dermatosis can precede, follow, or appear concurrent with the diagnosis of the patient's cancer. Hence, MASS can be the cutaneous harbinger of either an undiagnosed visceral malignancy in a previously cancer-free individual or an unsuspected cancer recurrence in an oncology patient. Drug-induced Sweet's syndrome (DISS most commonly occurs in patients who have been treated with granulocyte-colony stimulating factor, however, other medications may also be associated with DISS. The pathogenesis of Sweet's syndrome may be multifactorial and still remains to be definitively established. Clinical and laboratory evidence suggests that cytokines have an etiologic role. Systemic corticosteroids are the therapeutic gold standard for Sweet's syndrome. After initiation of treatment

  3. Flame figures associated with eosinophilic dermatosis of hematologic malignancy: is it possible to distinguish the condition from eosinophilic cellulitis in patients with hematoproliferative disease?

    Science.gov (United States)

    Qiao, Jianjun; Sun, Chang-E; Zhu, Weifang; Zhu, Dingxian; Fang, Hong

    2013-01-01

    Eosinophilic dermatosis of hematologic malignancy is a multifaceted dermatosis with a wide morphological spectrum, presenting as pruritic, erythematous, papular and occasionally vesicular, urticarial, nodular eruptions. Histopathologically eosinophil infiltration in the super and deep dermis was found. We reported a case of eosinophilic dermatosis of hematologic malignancy presented as urticarial and vesicular lesions in a patient with chronic lymphocytic leukemia. A skin biopsy revealed a prominent subepidermal blister and a diffuse infiltrate of eosinophils with flame figures in the dermis and subcutaneous tissue. Although flame figures associated with eosinophilic dermatosis of hematologic malignancy is rarely reported, we believe that it would not seem unusual to find them in this skin disease. Eosinophilic cellulitis, which share clinical and histological features with eosinophilic dermatosis of hematologic malignancy, has also been described as showing an association with hematoproliferative diseases. In order to clearly describe eosinophilic dermatosis in patients with hematologic malignancies, the terminology eosinophilic dermatosis of hematologic malignancy, instead of eosinophilic cellulitis, would be a more suitable term in patients with eosinophilic dermatosis.

  4. Psoríase pustulosa linear X Nevil: relato de caso Linear pustular psoriasis X ILVEN: case report

    Directory of Open Access Journals (Sweden)

    Maurício Pedreira Paixão

    2005-12-01

    Full Text Available A psoríase pustulosa linear (PPL e o nevo epidérmico verrucoso inflamatório linear (Nevil possuem características clínicas e histopatológicas semelhantes, o que enfatiza a importância da tentativa de distinção entre essas duas patologias a partir de aspectos clínico e laboratorial auxiliares. Relata-se o caso de uma mulher com 24 anos, que apresentou lesões eritêmato-descamativas pruriginosas, com distribuição linear unilateral (lado esquerdo do corpo. O exame clínico e os estudos histopatológicos sugeriram o diagnóstico de psoríase pustulosa linear, com um ano de evolução e resistente à corticoterapia.Linear pustular psoriasis (LPP and inflamamatory linear verrucous epidermal nevus (ILVEN possess overlapping clinical and histopathological characteristics, which emphasizes the importance of the attempt to distinguish between these two pathologies, based on clinical and ancillary laboratory data. Here we report the case of a 24-year-old woman, who presented with erythematous-desquamative, pruritic lesions, with a linear unilateral distribution (left side of the body. Clinical examination and histopathological studies suggested the diagnosis of linear pustular psoriasis, with one year of evolution, and resistant to steroid therapy.

  5. Calcium dobesilate (Cd) in pigmented purpuric dermatosis (PPD): a pilot evaluation.

    Science.gov (United States)

    Agrawal, Subhav Kumar; Gandhi, Vijay; Bhattacharya, Sambit Nath

    2004-02-01

    Pigmented purpuric dermatosis (PPD) is a chronic disorder of unknown etiology. It is quite common, and no therapy is significantly effective. Calcium dobesilate (Cd) has been tried successfully in many vascular disorders. The aim of this study was to evaluate the usefulness and efficacy of Cd in PPD. Nine male patients (7 with Schamberg's and 1 each with lichenoid dermatosis of Gougerot and Blum and lichen aureus) were given Cd 500 mg twice daily for two initial weeks and then 500 mg once daily for a total period of three months. All the patients were followed up for one year after cessation of therapy. The improvement was moderate in 11.11% and mild in 66.67% of cases; 22.22% did not show any improvement. New lesions stopped appearing in two weeks in all patients, and itching also improved in symptomatic cases without any significant side effects. Based upon the results of this pilot study we recommend Cd as the first line therapy for PPD.

  6. A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis

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    Pinky Jha

    2017-01-01

    Full Text Available Linear IgA bullous dermatosis (LABD is an autoimmune vesiculobullous disease, which is typically idiopathic but can also rarely be caused by medications or infections. Vancomycin is the most common drug associated with LABD. Lesions typically appear 24 hours to 15 days after the first dose of vancomycin. It is best characterized pathologically by subepidermal bulla (blister formation with linear IgA deposition at the dermoepidermal junction. Here we report an 86-year-old male with a history of left knee osteoarthritis who underwent a left knee arthroplasty and subsequently developed a prosthetic joint infection. This infection was treated with intravenous vancomycin as well as placement of a vancomycin impregnated joint spacer. Five days following initiation of antibiotic therapy, he presented with a vesiculobullous eruption on an erythematous base over his trunk, extremities, and oral mucosa. The eruption resolved completely when intravenous vancomycin was discontinued and colchicine treatment was begun. Curiously, complete resolution occurred despite the presence of the vancomycin containing joint spacer. The diagnosis of vancomycin-induced linear IgA bullous dermatosis was made based on characteristic clinical and histopathologic presentations.

  7. Ocular Involvement and Blindness Secondary to Linear IgA Dermatosis

    Science.gov (United States)

    Ramos-Castellón, Cinthya; Ortiz-Nieva, Gabriela; Fresán, Fernando; Villalvazo, Leonardo; Garfias, Yonathan; Navas, Alejandro; Jiménez-Martínez, María C.

    2010-01-01

    A 43-year-old man with linear immunoglobulin A (IgA) dermatosis associated with gluten intolerance presented with progressive vision loss, pain and photosensitivity in both eyes. His visual acuity was light perception (LP) in both eyes. A physical examination revealed bullous, papular lesions with erythematous borders in periocular tissues, limbs, and thorax. Slit-lamp examination showed conjunctival hyperemia, fibrosis, corneal opacification, and vascularization with epithelial defects. Immunofluorescent skin and corneal surface biopsy studies showed linear IgA deposits. The patient was treated with keratolimbal allogenic transplantation and cryopreserved amniotic membrane in the right eye. Regardless of the treatment he persisted with torpid evolution developing retinal and choroidal detachments. After these events he was started on intravenous immune globulin (IVIG) and showed very slight improvement in ocular surface. These types of blistering diseases are rare in the eye. Even when adequate local treatment is given, systemic treatment is mandatory and ocular prognosis can be unsatisfactory. PMID:21234343

  8. Bullous Dermatosis in an End-Stage Renal Disease Patient: A Case Report and Literature Review

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    Zeenat Yousuf Bhat

    2016-01-01

    Full Text Available Patients with advanced chronic kidney disease including ESRD patients may present with a wide spectrum of cutaneous abnormalities, ranging from xerosis to hyperpigmentation to severe deforming necrotizing lesions. Skin problems are not uncommon in this population of patients, with a clinical presentation that can be quite bizarre, mandating a long list of differential diagnostic possibilities, and subsequent rise of a puzzling diagnostic challenge. We describe an ESRD patient who presented with blistering, nonhealing ulcerative lesions with a diagnostic skin biopsy revealing a mixed pattern of linear IgA bullous dermatosis and dermatitis herpetiformis. A clinical remission could be achieved with pulse intravenous steroids followed by oral maintenance in combination with dapsone, with no evidence of recurrence.

  9. Ocular Involvement and Blindness Secondary to Linear IgA Dermatosis

    Directory of Open Access Journals (Sweden)

    Cinthya Ramos-Castellón

    2010-01-01

    Full Text Available A 43-year-old man with linear immunoglobulin A (IgA dermatosis associated with gluten intolerance presented with progressive vision loss, pain and photosensitivity in both eyes. His visual acuity was light perception (LP in both eyes. A physical examination revealed bullous, papular lesions with erythematous borders in periocular tissues, limbs, and thorax. Slit-lamp examination showed conjunctival hyperemia, fibrosis, corneal opacification, and vascularization with epithelial defects. Immunofluorescent skin and corneal surface biopsy studies showed linear IgA deposits. The patient was treated with keratolimbal allogenic transplantation and cryopreserved amniotic membrane in the right eye. Regardless of the treatment he persisted with torpid evolution developing retinal and choroidal detachments. After these events he was started on intravenous immune globulin (IVIG and showed very slight improvement in ocular surface. These types of blistering diseases are rare in the eye. Even when adequate local treatment is given, systemic treatment is mandatory and ocular prognosis can be unsatisfactory.

  10. Lateralized exanthem mimicking figurate inflammatory dermatosis of infancy after methimazole therapy.

    Science.gov (United States)

    Arrigo, T; Cutroneo, P M; Vaccaro, M; Impollonia, D; Squadrito, V; Mecchio, A; Salpietro, C; Altavilla, D

    2016-12-01

    We reported a case of an 11-year-old girl admitted to our hospital for goiter, tachycardia, sweating, and visible and palpable thyroid. Thyroid function tests revealed a low thyrotropin level (<0.004 mIU/L) and elevated free thyroxine level (3.4 ng/ dL) diagnosed with Graves' disease and treated with methimazole. This anti-thyroid drug is recommended as first-line treatment in children with Graves' disease because it produces minor adverse effects with respect to propylthiouracil. She developed a lateralized exanthem mimicking figurate inflammatory dermatosis of infancy after methimazole therapy. The symptoms resolved after discontinuation of methimazole and treatment with an antihistamine and a corticosteroid. Furthermore, the treatment was changed to propylthiouracil without any adverse effects. According to current literature this is the first case of cutaneous figurate erythema related to methimazole, different from other well-known reactions such as skin eruption or urticaria. © The Author(s) 2016.

  11. Functional state of the pituitary-thyroid system in children with allergic dermatosis

    Directory of Open Access Journals (Sweden)

    T.V. Sorokman

    2017-11-01

    Full Text Available Background. Approximately 10 % of the pediatric population suffers from atopic dermatitis, and this disease is most common skin allergic pathology. The influence of thyroid hormones on the development of atopy is known. Study purpose was to evaluate the features of the functional status of the pituitary-thyroid system in children with allergic dermatosis. Materials and methods. 72 children aged from 7 to 18 years were divided into 4 groups: group I — patients who suffer from atopic dermatitis (n = 29, II — children with allergic contact dermatitis (n = 17, III group — patients with simple contact dermatitis (n = 16, IV group — healthy children (n = 10. The levels of thyroxine, thyroid stimulating hormone, antibodies to thyroglobulin (TG were determined. Results. Erythema was found in 95.2 %, edema — in 43.5 %, exudation — in 37.1 %, excoriation — in 43.5 %, lichenification — in 56.4 % of the total group of patients. Dysfunctions of the pituitary-thyroid system, both at the central and peripheral level, were determined. The frequency of antibodies to TG detection in children of the first group was high and exceeded the average population values by 3.7 times (36.7 %, χ2 = 17.5, p < 0.05. The level of TG in all of observed patients was significantly higher than that of in the comparison group. The frequency of detection of antibo­dies to TG in the group of patients with the disease experience more than 10 years exceeded the average population values by 3.2 times (34.0 %, χ2 = 8.1, p < 0.05. Conclusions. Changes in the morpho-functional state of the pituitary-thyroid system, mainly of an autoimmune nature, are revealed in children with allergic dermatosis.

  12. Dermatosis neglecta in a case of multiple fractures, shoulder dislocation and radial nerve palsy in a 35-year-old man: a case report

    Directory of Open Access Journals (Sweden)

    Qadir Syed

    2008-11-01

    Full Text Available Abstract Introduction Dermatosis neglecta is an often misdiagnosed and under-diagnosed condition. In dermatosis neglecta, a progressive accumulation of sebum, sweat, keratin and other dirt and debris, occurs due to inadequate local hygiene resulting in a localized hyperpigmented patch or a verrucous plaque. Vigorous rubbing with alcohol-soaked gauze or soap and water results in a complete resolution of the lesion. This is the first case of dermatosis neglecta reported in a patient with multiple traumatic injuries. Case presentation We report a case of a 35-year-old male Caucasian of Pakistani origin, with multiple fractures, neurological deficit and immobility sustained in a fall, leading to the development of dermatosis neglecta of the left hand. Conclusion Early and prompt clinical recognition of this condition eliminates the need for aggressive diagnostic and therapeutic procedures.

  13. Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis in the cavalier King Charles spaniel.

    Science.gov (United States)

    Barnett, K C

    2006-09-01

    To record a previously unreported congenital and hereditary condition affecting the eyes and skin in the cavalier King Charles spaniel. Nineteen cases (13 litters) were investigated, with particular reference to eye and skin clinical signs. In addition, five generation pedigrees were obtained and studied from all cases with the exception of one. The eye signs were due to keratoconjunctivitis sicca, a common ocular disease in the dog, but rarely of congenital origin. The skin signs were of an ichthyosiform dermatosis; ichthyosis being a rare skin disease in the dog. In human beings, ichthyosis is a similar disease, mainly inherited and with a neonatal onset, and sometimes accompanied by other developmental defects. In the cavalier King Charles spaniel, the coat abnormality was noted at birth by the breeders as a 'curly coat', with deterioration of the skin signs as the animal became adult. These two conditions occurring together in this breed is well recognised by some breeders but rarely by the veterinary profession. Successful treatment is not possible, although some improvement, particularly of the keratoconjunctivitis sicca, can be obtained. The probable hereditary nature of the condition is an important factor for control.

  14. Clinical features and treatment of dermatosis papulosa nigra in migrants to Italy.

    Science.gov (United States)

    Calcaterra, Roberta; Franco, Gennaro; Valenzano, Mariacarla; Fazio, Raffaella; Morrone, Aldo

    2010-01-01

    Dermatosis papulosa nigra (DPN) is a benign epithelial tumor that is common in dark-skinned people. Although the diagnosis is easily made on medical examination, DPN is characterized by a chronic and worsening course. Therefore, even if DPN is a benign disease, the lesions are unaesthetic and the therapeutic options are quite inefficient. A prospective study was carried out during a period of 24 months (January 2006 to December 2007) at the Department for Preventive Medicine for Migration, Tourism and Tropical Dermatology of San Gallicano Dermatological Institute in Rome. Among 58 patients, 41 (71%) were women and 17 (29%) were men. The mean age was 33.5 years (range, 8-45 years). One pediatric patient was observed. This study is the first in Italy that, in recent years, has observed an important growth of the migration. The classic female predominance, family predisposition, and photodistribution of the lesion were found. DPN is frequently associated with patient discomfort, therefore the education of patients to reduce self-treatment is important.

  15. The program for eradication of infectious bovine rhinotracheitis/infectious pustular vulvovaginitis in the Republic of Serbia

    Directory of Open Access Journals (Sweden)

    Lazić Sava

    2016-01-01

    Full Text Available Infectious bovine rhinotracheitis/infectious pustular vulvovaginitis (IBR/IPV are diseases that affect cattle population of all breeds, categories and age. Both diseases, especially infectious bovine rhinotracheitis (IBR, poses severe health threat and causes major economic losses and is considered one of the “most costly” disease in cattle industry. The causal agent of the disease is a virus and any detection of IBR/IPV specific antibodies in non-vaccinated cattle, either in blood or milk, indicates that animal is infected and represents the source of infection. Countries with developed and intensive cattle breeding have been developed and implemented their national eradication programs to control IBR/IPV in accordance with international regulations. In this article, we outlined the needs and program for the eradication of IBR/IPV in the Republic of Serbia. The eradication program for IBR/IPV is an extensive process that requires systematic strategy involving different phases and activities. The eradication process from the moment of implementation until obtaining IBR/IPV-free status can last over several years and requires joint work and considerable financial resources that will be compansated with the elimination of IBR/IPV from the herd. This article gives an overview of all stages and activities regarding eradication of the disease and certification and maintaining of IBR/IPV-free herd status.

  16. Epidemiology and eradication of infectious bovine rhinotracheitis/infectious pustular vulvovaginitis (IBR/IPV virus in Finland

    Directory of Open Access Journals (Sweden)

    Hyytiäinen Mauno

    2007-01-01

    Full Text Available Abstract Background Infectious bovine rhinotracheitis/infectious pustular vulvovaginitis (IBR/IPV is a significant disease among domestic and wild cattle. The BHV-1 infection was first detected in Finland in 1970; presumably it was imported in 1968. The infection reappeared in the large-scale bulk-tank milk surveillances which started in 1990, and was eradicated in 1994. Our aim is to describe the epidemiology of this infection in Finland, and its eradication. Materials and methods The official sources of pertinent information, the legal basis for the disease control and the serological methods for the detection of the infection are described. Results and conclusion Ten AI bulls were found to be seropositive in 1970–1971. The total number of herds with BHV-1 antibody positive animals in the large-scale surveillance in 1990 and subsequent epidemiological investigations in 1991 was five, and the total number of seropositive animals was 90. The five herds formed three epidemiological units; semen of at least one bull seropositive in 1971 had been used in each unit. This remained the only plausible route of infection in each of the three units. Using the 'test and slaughter' approach and total stamping out in one herd the infection was eradicated in 1994.

  17. Clinical profile, morbidity, and outcome of adult-onset generalized pustular psoriasis: analysis of 102 cases seen in a tertiary hospital in Johor, Malaysia.

    Science.gov (United States)

    Choon, Siew Eng; Lai, Nai Ming; Mohammad, Norshaleyna A; Nanu, Nalini M; Tey, Kwee Eng; Chew, Shang Fern

    2014-06-01

    Generalized pustular psoriasis (GPP) is a severe but rare variant of psoriasis. Our objective is to review the clinical profile, comorbidities, and outcome of patients with GPP. A retrospective note review of all patients with adult-onset GPP. A total of 102 patients with adult-onset GPP were diagnosed between 1989 and November 2011, with a female to male ratio of 2 : 1. The mean age at onset of GPP was 40.9 years (range: 21-81 years). Acute GPP was the most common variant seen (95 cases), followed by four localized variants of GPP and three with annular pustular psoriasis. Fever and painful skin were present in 89% of patients, arthritis in 34.7%, and leukocytosis in 78.4%. Common triggers were systemic steroids (45 cases), pregnancy (17 cases), and upper respiratory tract infections (16 cases). A positive family history of psoriasis and GPP was present in 29% and 11%, respectively. Comorbidities included obesity (42.9%), hypertension (25.7%), hyperlipidemia (25.7%), and diabetes mellitus (23.7%). The mean duration of admission and pustular flare for acute GPP was 10.3 days (range: 3-44 days) and 16 days (range: 7-60 days), respectively. Fifty-four patients responded to systemic retinoid, 21 to methotrexate, eight to cyclosporine, and one to adalimumab, but recurrences were common. Our study confirms the poor response of GPP to currently available anti-psoriatic agents, with frequent flare-ups. There is a need for a more effective targeted therapy for this condition. © 2013 The International Society of Dermatology.

  18. Melorheostosis: Exome sequencing of an associated dermatosis implicates postzygotic mosaicism of mutated KRAS.

    Science.gov (United States)

    Whyte, Michael P; Griffith, Malachi; Trani, Lee; Mumm, Steven; Gottesman, Gary S; McAlister, William H; Krysiak, Kilannin; Lesurf, Robert; Skidmore, Zachary L; Campbell, Katie M; Rosman, Ilana S; Bayliss, Susan; Bijanki, Vinieth N; Nenninger, Angela; Van Tine, Brian A; Griffith, Obi L; Mardis, Elaine R

    2017-08-01

    Melorheostosis (MEL) is the rare sporadic dysostosis characterized by monostotic or polyostotic osteosclerosis and hyperostosis often distributed in a sclerotomal pattern. The prevailing hypothesis for MEL invokes postzygotic mosaicism. Sometimes scleroderma-like skin changes, considered a representation of the pathogenetic process of MEL, overlie the bony changes, and sometimes MEL becomes malignant. Osteopoikilosis (OPK) is the autosomal dominant skeletal dysplasia that features symmetrically distributed punctate osteosclerosis due to heterozygous loss-of-function mutation within LEMD3. Rarely, radiographic findings of MEL occur in OPK. However, germline mutation of LEMD3 does not explain sporadic MEL. To explore if mosaicism underlies MEL, we studied a boy with polyostotic MEL and characteristic overlying scleroderma-like skin, a few bony lesions consistent with OPK, and a large epidermal nevus known to usually harbor a HRAS, FGFR3, or PIK3CA gene mutation. Exome sequencing was performed to ~100× average read depth for his two dermatoses, two areas of normal skin, and peripheral blood leukocytes. As expected for non-malignant tissues, the patient's mutation burden in his normal skin and leukocytes was low. He, his mother, and his maternal grandfather carried a heterozygous, germline, in-frame, 24-base-pair deletion in LEMD3. Radiographs of the patient and his mother revealed bony foci consistent with OPK, but she showed no MEL. For the patient, somatic variant analysis, using four algorithms to compare all 20 possible pairwise combinations of his five DNA samples, identified only one high-confidence mutation, heterozygous KRAS Q61H (NM_033360.3:c.183A>C, NP_203524.1:p.Gln61His), in both his dermatoses but absent in his normal skin and blood. Thus, sparing our patient biopsy of his MEL bone, we identified a heterozygous somatic KRAS mutation in his scleroderma-like dermatosis considered a surrogate for MEL. This implicates postzygotic mosaicism of mutated KRAS

  19. Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis in 25 Cavalier King Charles spaniel dogs. Part I: clinical signs, histopathology, and inheritance.

    Science.gov (United States)

    Hartley, Claudia; Donaldson, David; Smith, Ken C; Henley, William; Lewis, Tom W; Blott, Sarah; Mellersh, Cathryn; Barnett, Keith C

    2012-09-01

    The clinical presentation and progression (over 9 months to 13 years) of congenital keratoconjunctivitis sicca and ichthyosiform dermatosis (CKCSID) in the Cavalier King Charles spaniel dog are described for six new cases and six previously described cases. Cases presented with a congenitally abnormal (rough/curly) coat and signs of KCS from eyelid opening. Persistent scale along the dorsal spine and flanks with a harsh frizzy and alopecic coat was evident in the first few months of life. Ventral abdominal skin was hyperpigmented and hyperkeratinized in adulthood. Footpads were hyperkeratinized from young adulthood with nail growth abnormalities and intermittent sloughing. Long-term follow-up of cases (13/25) is described. Immunomodulatory/lacrimostimulant treatment had no statistically significant effect on Schirmer tear test results, although subjectively, this treatment reduced progression of the keratitis. Histopathological analysis of samples (skin/footpads/lacrimal glands/salivary glands) for three new cases was consistent with an ichthyosiform dermatosis, with no pathology of the salivary or lacrimal glands identified histologically. Pedigree analysis suggests the syndrome is inherited by an autosomal recessive mode. © 2011 American College of Veterinary Ophthalmologists.

  20. Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases

    Science.gov (United States)

    2016-09-26

    Other Specified Inflammatory Disorders of Skin or Subcutaneous Tissue; Pyoderma Gangrenosum; Erosive Pustular Dermatosis of the Scalp; Sweet's Syndrome; Behcet's Disease; Bowel-associated Dermatosis-arthritis Syndrome; Pustular Psoriasis; Acute Generalized Exanthematous Pustulosis; Keratoderma Blenorrhagicum; Sneddon-Wilkinson Disease; IgA Pemphigus; Amicrobial Pustulosis of the Folds; Infantile Acropustulosis; Transient Neonatal Pustulosis; Neutrophilic Eccrine Hidradenitis; Rheumatoid Neutrophilic Dermatitis; Neutrophilic Urticaria; Still's Disease; Erythema Marginatum; Unclassified Periodic Fever Syndromes / Autoinflammatory Syndromes; Dermatitis Herpetiformis; Linear IgA Bullous Dermatosis; Bullous Systemic Lupus Erythematosus; Inflammatory Epidermolysis Bullosa Aquisita; Neutrophilic Dermatosis of the Dorsal Hands (Pustular Vasculitis); Small Vessel Vasculitis Including Urticarial Vasculitis; Erythema Elevatum Diutinum; Medium Vessel Vasculitis

  1. Orf: contagious pustular dermatitis.

    LENUS (Irish Health Repository)

    Nadeem, M

    2010-05-01

    Orf is a common viral infection in sheep. It spreads to humans by direct contact. It is self-limiting, treatment having no beneficial effect. Misdiagnosis by those unfamiliar with its characteristic features is common, and may result in unnecessary treatment with antibiotics or surgery. We present a series of five cases of Orf in children of farmers in the west of Ireland, seen over a 10 year period.

  2. CANDLE syndrome: chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature-a rare case with a novel mutation.

    Science.gov (United States)

    Cavalcante, Miria Paula V; Brunelli, Juliana B; Miranda, Clarissa C; Novak, Glaucia V; Malle, Louise; Aikawa, Nadia E; Jesus, Adriana A; Silva, Clovis Artur

    2016-05-01

    We described herein a patient with chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome and a novel mutation in PSMB8 gene. This patient had multiple visceral inflammatory involvements, including rare manifestations, such as Sweet syndrome and pericarditis. A 3-year-old male, Caucasian, was born to consanguineous healthy parents. At the age of 11 months, he presented daily fever (temperature >40 °C), irritability, hepatomegaly, splenomegaly; and tender and itching, erythematous papular and edematous plaque lesions. Echocardiogram showed mild pericarditis. Skin biopsy revealed a neutrophil infiltrate without vasculitis suggesting Sweet syndrome. Mutational screening of PSMB8 gene revealed homozygous c.280G>C, p.A94P mutation. He responded partially to high doses of oral glucorticoid and intravenous methylprednisolone. Colchicine, azathioprine, methotrexate, cyclosporine, and intravenous immunoglobulin were not efficacious. At the age of 3 years and 1 month, tocilizumab was administered resulting in remission of daily fever and irritability. However, there was no improvement of the skin tenderness and itching lesions. A new mutation in a CANDLE syndrome patient was reported with pericarditis and mimicking Sweet syndrome. The disease manifestations were refractory to immunosuppressive agents and partially responsive to tocilizumab therapy. • Proteasome-associated autoinflammatory syndromes (PRAAS) include four rare diseases. • Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome was seldom reported. What is New: • We described a Brazilian patient with CANDLE syndrome possessing a novel mutation in the PSMB8 gene. • This patient had multiple visceral inflammatory involvements, including rare manifestations, such as pericarditis and mimicking Sweet syndrome.

  3. Juvenile generalized pustular psoriasis is a chronic recalcitrant disease: an analysis of 27 patients seen in a tertiary hospital in Johor, Malaysia.

    Science.gov (United States)

    Lau, Bi-Wen; Lim, Dee-Zhen; Capon, Francesca; Barker, Jonathan N; Choon, Siew-Eng

    2017-04-01

    Limited information exists regarding juvenile generalized pustular psoriasis (GPP). We aim to determine the clinical profile and outcome of Malaysians with juvenile GPP. Review of hospital case notes on patients with juvenile GPP. Twenty-seven patients with juvenile GPP were identified. Female to male ratio was 1.4:1. The median age at onset of GPP was 6.5 years. Ten patients had prior psoriasis with a median pre-pustular duration of 2.7 years. Onset of GPP was earlier in patients without prior psoriasis (5.1 years vs. 12.0 years, P = 0.002). Precipitating factors identified included stress, upper respiratory tract infection, systemic steroid use, vaccination, and pregnancy. A positive family history of psoriasis and GPP was present in six and one patient(s), respectively. Twenty-one patients had acute, five annular, and one localized variant of GPP. Arthritis was present in 22.2%. Fever, leukocytosis, and transaminitis were mainly seen in patients with acute GPP at 80.9, 72.2, and 11.1%, respectively. Among 20 patients screened, eight carry IL36RN variants and one has CARD14 mutation. IL36RN-positive patients have more severe disease characterized by early onset, low prevalence of prior plaque psoriasis, high prevalence of systemic inflammation, and need for continuous long-term systemic therapy. Acitretin and cyclosporine were effective in aborting acute GPP in 100% of 16 and 66.7% of six patients treated, respectively. However, relapses were common. Only three of the 17 patients whose initial acute GPP was controlled with systemic agents were successfully weaned off treatment. Juvenile GPP is a chronic recalcitrant disease. IL36RN-positive patients have more severe disease. © 2017 The International Society of Dermatology.

  4. İMPETİGO HERPETİFORMİS: OLGU SUNUMU

    OpenAIRE

    ÖZEN, Dr.Gürsoy DOĞAN Dr. Ersoy HAZNECI Dr.Yel

    1999-01-01

    impetigo herpetiformis is a rare and often serious pustular dermatosis of pregnancy. Clinically and histologically, it bears some resemblance to pustular psoriasis. This similarity has led authors to name the disease the pustular psoriasis of pregnacy. We describe the case of a 24-year- old woman presenting with impetigo herpetiformis as compared to pustular psoriasis during her first pregnancy and emphasize the need to preserve the disease as a separate entity. Key words: impetigo herpet...

  5. Erosive papulonodular dermatosis associated with topical benzocaine: a report of two cases and evidence that granuloma gluteale, pseudoverrucous papules, and Jacquet's erosive dermatitis are a disease spectrum.

    Science.gov (United States)

    Robson, Kristi J; Maughan, Julie A; Purcell, Susan D; Petersen, Marta J; Haefner, Hope K; Lowe, Lori

    2006-11-01

    Granuloma gluteale infantum/adultorum, pseudoverrucous papules, and Jacquet's erosive diaper dermatitis are fairly uncommon manifestations of irritant contact dermatitis historically thought to be distinct clinical entities. Here we report two informative cases of an erosive papulonodular dermatosis in the genital and suprapubic area associated with topical benzocaine. We review granuloma gluteale infantum, pseudoverrucous papules and nodules, and Jacquet's erosive diaper dermatitis, and propose that these disorders may all be variants of genitocrural irritant dermatitis.

  6. Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis in Cavalier King Charles spaniel dogs. Part II: candidate gene study.

    Science.gov (United States)

    Hartley, Claudia; Barnett, Keith C; Pettitt, Louise; Forman, Oliver P; Blott, Sarah; Mellersh, Cathryn S

    2012-09-01

    To identify causative mutation(s) for congenital keratoconjunctivitis sicca and ichthyosiform dermatosis (CKCSID) in Cavalier King Charles spaniel (CKCS) dogs using a candidate gene approach. DNA samples from 21 cases/parents were collected. Canine candidate genes (CCGs) for similar inherited human diseases were chosen. Twenty-eight candidate genes were identified by searching the Pubmed OMIM database (http://www.ncbi.nlm.nih.gov/omim). Canine orthologues of human candidate genes were identified using the Ensembl orthologue prediction facility (http://www.ensembl.org/index.html). Two microsatellites flanking each candidate gene were selected, and primers to amplify each microsatellite were designed using the Whitehead Institute primer design website (http://frodo.wi.mit.edu/primer3/). The microsatellites associated with all 28 CCGs were genotyped on a panel of 21 DNA samples from CKCS dogs (13 affected and eight carriers). Genotyping data was analyzed to identify markers homozygous in affected dogs and heterozygous in carriers (homozygosity mapping). None of the microsatellites associated with 25 of the CCGs displayed an association with CKCSID in the 21 DNA samples tested. Three CCGs associated microsatellites were monomorphic across all samples tested. Twenty-five CCGs were excluded as cause of CKCSID. Three CCGs could not be excluded from involvement in the inheritance of CKCSID. © 2012 American College of Veterinary Ophthalmologists.

  7. Topical ALA-PDT as alternative therapeutic option in treatment-recalcitrant dermatosis: Report of 4 cases.

    Science.gov (United States)

    Theresia, Calvina; Zheng, Jie; Chen, Xiao-Ying

    2017-12-01

    Topical Photodynamic therapy (PDT) is widely acknowledged for its safety and effectiveness in treating oncologic skin diseases such as basal cell carcinoma, actinic keratosis and squamous cell carcinoma in situ. Despite its broad applications in dermatology, this method is a relatively new therapeutic option for treating inflammatory/infectious skin diseases. To determine whether topical PDT is a safe and effective treatment option in treating treatment-recalcitrant dermatosis. We presented one of each case of Acne Vulgaris, facial flat warts, urethral meatus Condyloma Acuminatum and extramammary Paget's disease, where other treatment options were either ineffective or not feasible, then those patients underwent topical PDT and showed significant improvement with minimal side effects. Topical PDT therapy may be applied in cases of Acne Vulgaris, facial flat warts, urethral meatus Condyloma Acuminatum and extramammary Paget's disease, where other treatment has shown no or minimal improvement, or in whom ablative or invasive procedure is to be avoided or not well tolerated. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Carbon dioxide laser ablation of dermatosis papulosa nigra: high satisfaction and few complications in patients with pigmented skin.

    Science.gov (United States)

    Ali, Faisal R; Bakkour, Waseem; Ferguson, Janice E; Madan, Vishal

    2016-04-01

    Dermatosis papulosa nigra (DPN) is a common condition of pigmented skin. Whilst lesions are benign, they may be symptomatic or cosmetically disfiguring. Ablative lasers have previously been reported as a useful therapeutic modality in DPN. We report the largest case series to date of patients with DPN ablated with the carbon dioxide (CO2) laser. A retrospective case note review was conducted of all patients with DPN treated in our laser clinic in the last five years, and a post-treatment telephone survey was undertaken to assess patient satisfaction. Forty-five patients were identified, with a median age of 41 years (range 25-74 years), of whom 37 (82%) were female. The median number of treatments undertaken was three (range 1-10). Of the 18 respondents to the telephone survey, when asked to grade their satisfaction with the procedure out of 10, median response was 9.5 (range 6-10) with nine patients citing the maximum score of 10. All patients replied that their confidence had improved following the procedure and that they would recommend the treatment to other patients. Five respondents (28%) reported recurrence of a few lesions following CO2 laser ablation; the remaining 13 respondents (72%) reported no recurrence of DPN. No respondents reported any other post-procedural complications (including scarring, hypopigmentation and hyperpigmentation). We advocate use of the CO2 laser as a safe, convenient means of treating DPN, with a high degree of patient satisfaction, low recurrence rate and few complications.

  9. Análisis de un caso de dermatosis autoprovocada ("El Hombre de los Pastos Verdes": Presentación del Síndrome PADDLE Analysis of a case of self-induced dermatosis ("The Man of the Green Grass": Presentation of the PADDLE' s Syndrome

    Directory of Open Access Journals (Sweden)

    E J Restifo

    2008-12-01

    Full Text Available Se presenta el caso de un paciente afectado de una dermatosis autoprovocada donde se aplicó la escucha psicoanalítica. Dentro de los comentarios se lleva a la consideración del lector, la posibilidad de pensar que ciertos casos de dermatosis psicosomáticas pueden ser reversibles a través de la escucha analítica, como contrapunto frente a la tendencia actual de encasillar los pacientes dentro de algún trastorno psiquiátrico. Se pone a consideración un nuevo síndrome con componentes sensoriales y afectivos: el Síndrome PADDLE.A case of a patient suffering from a skin self applied where psychoanalytic listening was experimented. Among the comments is the consideration of the reader to believe that some cases of psychosomatic dermatosis may be reversible through analytical listening, as a counterpoint against the current trend classify patients within a psychiatric disorder. Set to consider a new syndrome with sensory and emotional components: PADDLE syndrome.

  10. Fototerapia con radiación ultravioleta (UVB) de banda estrecha: una opción segura de manejo para vitiligo y otras dermatosis

    OpenAIRE

    Ricardo Flaminio Rojas López, MD; Jéssica Inés Vergara Rueda, MD

    2010-01-01

    La radiación UVB de banda estrecha es una modalidad de fototerapia, empleada en diversas enfermedades dermatológicas. Ha obtenido gran auge en los últimos años por su eficacia y pocos efectos adversos. Es considerada de elección en vitiligo generalizado y además es útil en psoriasis en placas, dermatitis atópica y estadíos iniciales de micosis fungoides, entre otras dermatosis. Debe valorarse en formaclara la indicación de su uso y otras alternativas disponibles, así como patologías o condici...

  11. Efficacy and safety of ixekizumab treatment for Japanese patients with moderate to severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis: Results from a 52-week, open-label, phase 3 study (UNCOVER-J).

    Science.gov (United States)

    Saeki, Hidehisa; Nakagawa, Hidemi; Nakajo, Ko; Ishii, Taeko; Morisaki, Yoji; Aoki, Takehiro; Cameron, Gregory S; Osuntokun, Olawale O

    2017-04-01

    Psoriasis, a chronic, immune-mediated skin disease characterized by red, scaly plaques, affects approximately 0.3% of the population in Japan. The aim of this open-label study was to evaluate the long-term efficacy and safety of ixekizumab, a humanized, anti-interleukin-17A monoclonal antibody, in Japanese patients with plaque psoriasis (n = 78, including 11 psoriatic arthritis), erythrodermic psoriasis (n = 8) and generalized pustular psoriasis (n = 5). Ixekizumab was administrated s.c. at baseline (week 0, 160 mg), from weeks 2 to 12 (80 mg every 2 weeks), and from weeks 16 to 52 (80 mg every 4 weeks). At week 52, 92.3% of patients with plaque psoriasis achieved Psoriasis Area and Severity Index (PASI) 75, 80.8% achieved PASI 90, 48.7% achieved PASI 100, and 52.6% had remission of plaques (by static Physician Global Assessment, sPGA [0]). Difficult to treat areas of psoriasis (nail or scalp) also responded to ixekizumab. All patients with psoriatic arthritis who were assessed (5/5) achieved an American College of Rheumatology 20 response. Most patients with erythrodermic psoriasis or generalized pustular psoriasis responded to ixekizumab and the clinical outcome was maintained over 52 weeks (75% and 60% of patients achieved sPGA [0, 1] at week 52, respectively). Mostly mild or moderate treatment-emergent adverse events were reported by 79 of 91 patients; the most common were nasopharyngitis, eczema, seborrheic dermatitis, urticaria and injection site reactions. In conclusion, 52-week ixekizumab treatment was efficacious and well tolerated in Japanese patients with plaque psoriasis. Efficacy was also observed in patients with erythrodermic psoriasis, generalized pustular psoriasis and psoriatic arthritis. © 2016 Eli Lilly Japan K.K. The Journal of Dermatology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Dermatological Association.

  12. Safety profiles and efficacy of infliximab therapy in Japanese patients with plaque psoriasis with or without psoriatic arthritis, pustular psoriasis or psoriatic erythroderma: Results from the prospective post-marketing surveillance.

    Science.gov (United States)

    Torii, Hideshi; Terui, Tadashi; Matsukawa, Miyuki; Takesaki, Kazumi; Ohtsuki, Mamitaro; Nakagawa, Hidemi

    2016-07-01

    A large-scale prospective post-marketing surveillance was conducted to evaluate the safety and efficacy of infliximab in Japanese patients with plaque psoriasis, psoriatic arthritis, pustular psoriasis and psoriatic erythroderma. This study was conducted in all psoriasis patients treated with infliximab after its Japanese regulatory approval. Infliximab was administrated at 5 mg/kg at weeks 0, 2 and 6, and every 8 weeks thereafter. Patients were serially enrolled and observed for 6 months to evaluate the safety and efficacy. The safety and efficacy were evaluated in 764 and 746 patients, respectively. Incidences of any and serious adverse drug reactions were 22.51% and 6.94%, respectively, and those of any and serious infusion reactions were 6.15% and 1.31%, respectively, which were comparable with the results in the post-marketing surveillance with 5000 rheumatoid arthritis patients in Japan. Major adverse drug reactions during the follow-up period were infections (5.10%) including pneumonia, cellulitis and herpes zoster, however, no tuberculosis was observed. The safety profiles were equivalent, regardless of the psoriasis types. No new safety problems were identified. The response rates on global improvement and median improvement rate of Psoriasis Area and Severity Index in all patients were 88.0% and 85.0%, respectively. Of note, the efficacy was equivalent for each psoriasis type as well as for each body region. Infliximab was also effective in pustular psoriasis symptoms, joint symptoms and nail psoriasis, as well as improvement of quality of life. Infliximab was confirmed to be highly effective and well tolerated in treating refractory psoriasis, including pustular psoriasis and psoriatic erythroderma. © 2015 Japanese Dermatological Association.

  13. ECTIMA CONTAGIOSO (DERMATITE PUSTULAR DOS OVINOS

    Directory of Open Access Journals (Sweden)

    Monica Weismann Seabra Salles

    1992-12-01

    Full Text Available É descrito um surto de ectima contagioso em ovinos no Rio Grande do Sul nos meses de junho e julho. Setenta (78% de um total de 90 cordeiros de 10 a 45 dias de idade foram afetados. Não houve mortes. Também 3 ovelhas adultas desenvolveram lesões discretas na pele ao redor da boca. Os cordeiros apresentavam proliferações crostosas firmes, nodulares ou em forma de placas na pele da boca e junção mucocutânea da cavidade oral. Lesões proliferativas não ulceradas em forma de placa eram observadas no palato duro e almofada dental. Lesões proliferativas extensas, vegetantes, ocorriam na gengiva ao longo dos molares superiores e inferiores. Um cordeiro fêmea de 45 dias de idade foi sacrificado e necropsiado. As principais lesões microscópicas consistiam de epitélio hiperplástico pseudoepiteliomatoso com hiper e paraqueratose, cobrindo a derme ou a lâmina própia que se encontrava acentuadamente infiltrada por macrófagos, neutrófilos e linfócitos. Inclusões acidofílicas intracitoplasmáticas eram vistas nas células epiteliais da pele e da mucosa oral. Pústulas foram observadas na epiderme e mucosa oral. Vasculite associada a trombose era vista nos vasos da derme e lâmina própia. Numerosas partículas víricas com morfologia compatível com parapoxvírus foram encontradas em associação com as lesões epiteliais, ao exame no microscópio eletrônico. A epidemiologia, patogenia, meios de diagnóstico e profilaxia do ectima contagioso são discutidos.

  14. Genetics Home Reference: generalized pustular psoriasis

    Science.gov (United States)

    ... 2015 Apr;135(4):1067-70.e9. doi: 10.1016/j.jaci.2014.09.043. Epub 2014 Nov ... 2012 May 4;90(5):796-808. doi: 10.1016/j.ajhg.2012.03.013. Epub 2012 Apr ... 2011 Sep 9;89(3):432-7. doi: 10.1016/j.ajhg.2011.07.022. Epub 2011 Aug ...

  15. [Ultrasound in the management of inflammatory dermatosis].

    Science.gov (United States)

    Habicheyn Hiar, S; Segura Palacios, J M; Bernal Ruiz, A I

    2015-11-01

    Cutaneous ultrasound is a dermatological diagnostic imaging technique based on the interaction of high-frequency ultrasounds with the skin. Because it is non-invasive, rapid and accessible, it has increasingly wide clinical applications. This article reviews its use in the management of inflammatory dermatological diseases. Copyright © 2015 Academia Española de Dermatología y Venereología. Published by Elsevier España, S.L.U. All rights reserved.

  16. Dermatosis pigmentada y purpúrica

    Directory of Open Access Journals (Sweden)

    Gonzalo Reyes García

    1938-01-01

    Full Text Available Se presentó a la consulta de enfermedades de la piel en el Hospital de San Juan de Dios un hombre de 32 años de edad, natural de Pesca, Boyacá, con una mancha en la cara que cubría la nariz, parte de las mejillas y llegaba a afectar el pabellón de las orejas, lesión que llamó mucho nuestra atención por no haberla visto en la práctica profesional. Ni sus padres, ni hermanos han tenido enfermedad semejante a la que él padece. Nos refiere que algunos parientes colaterales sufrieron de enfermedades mentales. El enfermo procede de tierra fría, allí siempre ha vivido entregado a los oficios del campo. Desde hace varios años ha sufrido de dolores reumáticos. Hace unos tres años notó que sobre las mejillas tenía unas manchas del tamaño de una moneda de centavo y de un color más claro que el resto de la piel, que desaparecieron sin dejar huellas. Unos meses después observó que en el mismo sitio presentaba unas manchas de color rosado oscuro, que rápidamente invadieron parte de las mejillas y la nariz, al mismo tiempo notó que tenía menos aptitudes para el trabajo, sentía dolores abdominales vagos, acompañados de diarrea, por lo cual resolvió venir al hospital.

  17. A case of Cinderella: erythema dyschromicum perstans (ashy dermatosis or dermatosis cinecienta).

    Science.gov (United States)

    Muñoz, Claudia; Chang, Anne Lynn S

    2011-01-01

    A 33-year-old healthy Latina (from either Mexico or Central America) woman with Fitzpatrick type V skin complained of a 2-year history of progressive hyperpigmentation on the axillary folds, dorsal hands, upper neck spilling onto the jawline area, and lower abdomen. There was no preceding dermatitis. The lesions were asymptomatic. She did not use any prescription or over-the-counter drugs or any herbal supplements. She denied contact with any new substances and did not start any new activities. A full review of systems was negative. Physical examination revealed diffuse symmetric gray patches on the proximal arms radiating from the axillary folds with extension onto the trunk (Figure 1). This discoloration was also present on the dorsal hands (Figure 2), upper neck and jawline, and lower abdomen. The lesions were nonpalpable and without erythema. Thyroid function test results and morning cortisol levels were normal. Two adjacent 4-mm punch biopsies were performed on the right axillary skin, one consisted of unaffected skin and one of hyperpigmented skin. Figure 3 shows affected axillary skin with an interface dermatitis and significant pigment dropout. There was no evidence of depositional process of substances such as heavy metals, drugs, or tattoo. There was no evidence of an actinic process. Differential diagnosis included erythema dyschromicum perstans (EDP), fixed-drug reaction, or interface drug reaction. As the patient was not taking any medications, the overall clinical and histologic impression was most consistent with EDP. The patient was started on a low-potency topical steroid twice a day to the affected areas. In addition, because the patient was concerned about the cosmetic appearance of the hyperpigmentation, a 4% hydroquinone cream was started twice daily to the neck area.

  18. DEFICIENCY OF INTERLEUKIN-1 RECEPTOR ANTAGONIST RESPONSIVE TO ANAKINRA

    Science.gov (United States)

    SCHNELLBACHER, CHARLOTTE; CIOCCA, GIOVANNA; MENENDEZ, ROXANNA; AKSENTIJEVICH, IVONA; GOLDBACH-MANSKY, RAPHAELA; DUARTE, ANAM.; RIVAS-CHACON, RAFAEL

    2012-01-01

    We describe a 3-month-old infant who presented to our institution with interleukin (IL)-1 receptor antagonist deficiency (DIRA), which consists of neutrophilic pustular dermatosis, periostitis, aseptic multifocal osteomyelitis, and persistently high acutephase reactants. Skin findings promptly improved upon initiation of treatment with anakinra (recombinant human IL-1 receptor antagonist), and the bony lesions and systemic inflammation resolved with continued therapy. PMID:22471702

  19. Tumor necrosis factor inhibitor-induced pustular psoriasis?

    Science.gov (United States)

    Heymann, Warren R

    2007-02-01

    Dialogues in Dermatology, a monthly audio program from the American Academy of Dermatology, contains discussions between dermatologists on timely topics. Commentaries from Dialogues Editor-in-Chief Warren R. Heymann, MD, are provided after each discussion as a topic summary and are provided here as a special service to readers of the Journal of the American Academy of Dermatology.

  20. Acute Generalized Exanthematous Pustulosis Induced by Cefepime: A Case Report

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    L.F.F. Botelho

    2010-06-01

    Full Text Available Acute generalized exanthematous pustulosis (AGEP is a rare cutaneous rash characterized by widespread sterile nonfollicular pustules. Cefepime is a fourth generation cephalosporin, used to treat severe infections. A 67-year-old man was admitted with acute gastroenterocolitis. On the seventh day, the patient developed a nosocomial pneumonia and cefepime was initiated. On the fourth day of cephalosporin treatment, he presented with a maculopapular, pruritic eruption affecting the face, neck, abdomen and limbs. One day later he developed disseminated pustular lesions and his temperature was 37°C. Laboratory analysis evidenced leukocytosis and skin biopsy showed subcorneal pustule, edema in the papillary dermis, perivascular inflammatory infiltrate consisting of neutrophils, leukocytoclasia and red cell extravasation in the epidermis. Cefepime was suspended and within 4 days the non-follicular pustules cleared following a desquamation. AGEP is a disease attributed to a variety of causes, but in 90% of the cases it is due to an adverse drug reaction. Antibiotics are implicated in 80% of these cases, mostly penicillins and macrolides. There are few cases associated with cephalosporins. It is very important to consider AGEP in cases of acute pustular rashes and drugs should be investigated as causative agents.

  1. Dermatosis de origen alimentario al regreso de un viaje: gnathostomiasis

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    Tomás A. Orduna

    2013-12-01

    Full Text Available Se describe el caso de un paciente de 32 años de edad, residente en Buenos Aires, con manifestaciones dermatológicas compatibles con gnathostomiasis. Había realizado un viaje a Colombia en el mes previo a la aparición de la sintomatología. Allí consumió cebiche (pescado crudo marinado en jugo de limón en reiteradas oportunidades. El cuadro clínico se presentó como paniculitis eritematosa y migratoria acompañada de eosinofilia sanguínea. Se le realizó biopsia cutánea de una lesión y el diagnóstico anatomopatológico fue "paniculitis eosinofílica". La tríada de paniculitis migratoria, eosinofilia sanguínea y el consumo de pescado crudo durante el viaje a Colombia fue sugestiva de gnathostomiasis por lo que se indicó tratamiento con ivermectina con buena evolución inicial y recaída posterior. Se realizó un nuevo tratamiento con la misma droga con buena evolución y sin recaídas durante tres años de seguimiento. La afección dermatológica es un motivo frecuente de consulta al regreso de un viaje, y representa la tercera causa de morbilidad en viajeros. Es muy importante el reconocimiento de las enfermedades que pueden tener manifestación cutánea, ya que muchas de ellas son potencialmente graves y pueden poner en riesgo la vida del paciente si no son oportunamente diagnosticadas y tratadas.

  2. Dermatitis neglecta -- A dirty dermatosis: Report of three cases

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    Abhijit Saha

    2015-01-01

    Full Text Available Dermatitis neglecta is a condition that results from inadequate frictional cleansing leading to accumulation of corneocytes, sebum and sweat ultimately resulting in hyper-pigmented patch or verrucous plaque. Recognizing this condition avoids unnecessary, aggressive diagnostic and therapeutic procedures. Here we report three cases of dermatitis neglecta in whom the dermatitis developed as a result of intentional neglect of personal hygiene.

  3. A case of multiple myeloma presenting as a bullous dermatosis

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    Gul Ulker

    2008-01-01

    Full Text Available Multiple myeloma is a malignant plasma cell proliferative disorder that produces a monoclonal immunoglobulin protein. The skin involvement and the development of bullous disease are rarely seen features in multiple myeloma. We present a 55-year-old man with a longstanding, large, tense bullous eruption and hypertrophic scars over his body accompanied recently with weight loss and fatique. He had no response to the previous treatments, which included oral glucocorticoids and dapsone. Histologic examination of the lesions revealed subepidermal bullae, while no immunoflourescence staining was observed. In a further detailed labarotory examination, multiple myeloma was detected. After the treatment of multiple myeloma with chemotherapy, the lesions regressed. Patients with longstanding, recurrent, unusual bullous eruption should be investigated for the development of multiple myeloma.

  4. Amyloidosis cutis dyschromica: A rare reticulate pigmentary dermatosis

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    Shyam Verma

    2015-01-01

    Full Text Available We are reporting a rare case of amyloidosis cutis dyschromica in a 41-year-old man. This is a rare form of primary cutaneous amyloidosis characterized by reticulate pigmentation with hypopigmented and hyperpigmented macules, onset in childhood, familial tendency in some, occasional mild itching and deposition of amyloid in the papillary dermis. Our case also had multiple bilaterally symmetrical hyperpigmented keratotic papules abutting the axillary vault resembling those seen in Dowling-Deogs disease. The other unusual feature in this patient was the strong family history of vitiligo, which we are unable to explain. We have also tried to explain the mechanism leading to the hyperpigmentation and hypopigmentation in amyloidosis cutis dyschromica.

  5. Zinc-responsive acral hyperkeratotic dermatosis-A novel entity or a subset of some well-known dermatosis?

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    Arghyaprasun Ghosh

    2015-01-01

    Full Text Available Background: We are reporting a series of interesting cases, which presented to us with psoriasiform lesions distributed over the acral regions of the body. The cases are unusual because they were resistant to conventional treatment modalities like topical corticosteroids, tacrolimus and oral methotrexate but showed significant improvement on oral zinc therapy. Materials and Methods: Ten patients with characteristic clinical features of distinctive hyperkeratotic plaque in the acral areas, who were resistant to treatment by different modalities including potent topical steroids and oral methotrexate, were included for detailed investigations. A proper history was taken and relevant laboratory investigations were done which included blood count, urine, liver function, renal function, hepatitis-C virus serology and serum zinc levels. Patients were followed up every 2 weeks. Histopathological examinations of the lesional tissue were done at baseline and after 6 weeks of therapy. Patients were given oral zinc daily and no other treatment during the 6 weeks course. Results: All our patients were non-reactive to hepatitis-C. Of the ten patients only one patient (10% showed low titer of serum zinc, another (10% showed higher zinc level, while the rest of the patients had normal zinc level. Five of our patients had chronic renal failure, one had Grave′s disease and the remaining had no associated systemic illness. Histopathology mostly showed hyperkeratosis, acanthosis, prominent granular layer, spongiosis and dermal infiltrate. After 6 weeks of follow up, all patients showed rapid and remarkable therapeutic response with zinc. Conclusions: We here report a series of patients, discernible because of their uniform clinical presentation of acral hypekeratotic plaques and in showing a noticeable response to zinc. Clinical, histopathological and laboratory investigations were done to rule out diseases of similar morphology including psoriasis, acral necrolytic erythema and lichen simplex chronicus. Authors understand that further studies with greater number cases and more detailed investigations are required to establish exact etio-pathogenesis and nomenclature of this distinct subset of patients.

  6. Recurrent impetigo herpetiformis: case report.

    Science.gov (United States)

    Wamalwa, Emmanuel Wekesa

    2017-01-01

    Impetigo herpetiformis (pustular psoriasis of pregnancy) is a rare dermatosis of pregnancy that typically starts in the 2nd half of pregnancy and resolves postpartum. It may recur in subsequent pregnancies. I present a case of 23 year old female gravida 4 para 3 with recurrent impetigo herpetiformis at 26 weeks gestation. She presented with a one month history of pustular lesions which responded to treatment with prednisone. She delivered at term with a favourable outcome. The disease resolved one month postpartum. This was the second recurrence of the disease. She had her first episode of impetigo herpetiformis during the second pregnancy. The disease recurred in the 3rd pregnancy and resulted in a still birth.

  7. İmpetigo Herpetiformis: Olgu Sunumu

    OpenAIRE

    Tosun, M.; MALATYALIOĞLU, E.; KÖKÇÜ, A.; ÇETİNKAYA, M.B.; Alper, T.

    2009-01-01

    Impetigo Herpetiformis: Case Report Impetigo herpetiformis is one of the rare and serious pustular dermatosis that mostly occurs in pregnancy. Early recognition is important to reduce both of maternal and fetal morbidity and mortality. In this article we discussed the management of a pregnant case of 23-year-old at her first pregnancy and presenting with impetigo herpetiformis. İmpetigo herpetiformis çoğunlukla gebelikte ortaya çıkan nadir ve ciddi püstüler dermatozlardan biridir. E...

  8. Coexistence of disseminated granuloma annulare and asymptomatic multiple myeloma

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    Şebnem Aktan

    2013-09-01

    Full Text Available Granuloma annulare (GA is a benign inflammatory dermatosis of unknown cause, characterized by necrobiotic dermal papules. Several morphologic forms of GA including localized, disseminated, linear, nodular, perforating, subcutaneous, pustular and arcuate dermal erythema have been reported in the literature. Disseminated GA, a rarely seen form, has been reported in association with some hematopoietic and solid malignancies; however, it has been suggested that the exact causative relationship between malignancy and GA is unclear. We present here a 66-year-old female patient with disseminated GA associated with asymptomatic multipl myeloma.

  9. Misleading pustular plaques of the lower limbs during Crohn's disease: two case reports

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    Farhi David

    2007-10-01

    Full Text Available Abstract Background Extraintestinal manifestations of Crohn's disease may involve the skin, the eyes, the genital mucosa, and the joints. Dermatoses associated with Crohn's disease include neutrophilic dermatoses, erythema nodosum, granulomatous dermatitis, blistering dermatoses, and non-specific skin manifestations. Cutaneous Crohn's disease is characterized by skin non-caseating epithelioid granulomatas with giant cells, remote from the gastrointestinal tract. We report herein two new cases. Observations On both patients, differential diagnosis of neutrophilic dermatoses and infectious disease were evoked, and antimicrobial agents were introduced in one of them. Given the atypical presentation, the final diagnosis of cutaneous Crohn's disease could only be made with histological examination. In patient 1, the plaques decreased in size and infiltration by more than 75% after 3 weeks of treatment with bethametasone dipropionate 0.05% cream. In patient 2, the plaques decreased by more than 50% after 6 weeks of treatment with prednisolone (45 mg/day and azathioprine (100 mg/day. Discussion Cutaneous Crohn's disease may present as dusky, erythematous, infiltrated, and ulcerated plaques and nodules. Female-to-male sex ratio is about 2, and the mean age at onset is 35. Recurrently, the hypothesis of a skin mycobacterial or fungal infection greatly delays proper treatment. Rarity of cutaneous Crohn's disease hampers therapeutic assessment in controlled trials. Thus, available literature is limited to case reports and sparse small series, with contradictory results. These reports are subject to publication bias, and no definite evidence-based recommendations can be made on the most adequate therapeutic strategy.

  10. Pênfigo foliáceo em um eqüino Pemphigus foliaceus in a horse

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    Gabriel Augusto Monteiro

    2007-04-01

    Full Text Available Pênfigo foliáceo é uma rara afecção cutânea auto-imune que acomete várias espécies. Relata-se o caso de uma égua de quatro anos de idade, sem raça definida, apresentando áreas de alopecia, exsudação e crostas localizadas na face, região peitoral e membros pélvicos, além de prurido. Os exames laboratoriais para pesquisa de ácaros, bactérias e estruturas fúngicas foram negativos. O exame histopatológico revelou uma dermatite pustular intra-epidérmica com acantólise subcorneal, assim como dermatite perivascular superficial, com infiltração de eosinófilos, sendo o quadro compatível com pênfigo foliáceo.Pemphigus foliaceus is an uncommon autoimmune skin disorder affecting various species. A case of a 4-year-old mare of undefined breed, displaying alopecic areas, exsudation and crusty lesions on the face, breast region, and hindlimbs as well as pruritus, is reported. Laboratory exams for mite, bacteria and fungal structures were negative. Histopathological exam revealed an intra-epidermal pustule dermatitis with acantholysis, as well as superficial perisvascular dermatitis with infiltration of eosinophyles, conditions compatible with pemphigus foliaceus.

  11. Acute generalized exanthematous pustulosis: report of five cases and systematic review of clinical and histopathological findings.

    Science.gov (United States)

    Vassallo, C; Derlino, F; Brazzelli, V; D'Ospina, R D; Borroni, G

    2014-06-01

    Acute generalized exanthematous pustulosis (AGEP) is a rare, drug-related pustular eruption usually starting from folds with edema and erythema and with subsequent spreading. Clinically AGEP is characterized by the sudden appearance of dozen of sterile, non follicular, small pustules on erythematous and edematous skin. Mild non erosive mucosal involvement, mostly oral, may sometimes occur. Fever, neutrophilia and peripheral blood eosinophilia (in a third of patients) are present. Other skin signs such as facial edema, purpura, target-like lesions and blisters have been described but are not typical for AGEP. Diagnostic criteria for AGEP were established by an international committee of experts, the European Study of Severe Cutaneous Adverse Reactions (EuroSCAR). The most relevant histopathological feature is represented by the detection of non-follicular subcorneal and/or intracorneal spongiform pustules that are usually large, contiguous and tend to coalesce. After elimination of the causative drug, pustules usually spontaneously disappear in a few days with desquamation and the reaction fully resolves within 15 days. Internal organs are not usually involved and no systemic treatment is required. Withdrawal of the culprit drug is mandatory. Although AGEP is a self-limiting disease with a favourable prognosis, secondary infections are a not infrequent complication in patients in poor general medical conditions. The reported mortality is about 5%. The most severe cases are associated with drug rechallenge.

  12. Impetigo herpetiformis with gestational hypertension: a case report and literature review.

    Science.gov (United States)

    Huang, Y H; Chen, Y P; Liang, C C; Chang, Y L; Hsieh, C C

    2011-01-01

    Impetigo herpetiformis (IH) is a rare skin disorder that occurs during pregnancy. It was previously associated with high maternal and fetal mortality and morbidity, but now has a better prognosis. We report a case of a pregnant woman with IH who presented with generalized erythematous pustular eruptions in the 32nd week of gestation. The IH progressed rapidly, and gestational hypertension was observed in the 36th week. The lesions did not subside, despite treatment with corticosteroids and phototherapy. She delivered a healthy male baby via cesarean section in the 37th week. One month after her delivery, her skin returned to normal, except for residual pigmentation, with complete recovery 3 months postpartum. An experienced medical team comprising obstetricians, dermatologists, perinatologists and neonatologists is critical to aggressively treat this life-threatening specific dermatosis of pregnancy and to prevent ensuing complications, such as fluid and electrolyte imbalance, secondary infection and placental insufficiency. Copyright © 2011 S. Karger AG, Basel.

  13. Rosacea – new data on pathogenesis and treatment

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    Waldemar Placek

    2016-10-01

    Full Text Available Rosacea is a common dermatosis more prevalent in females, significantly impairing quality of life. Currently erythematous, papulo-pustular and phymatous subtypes are distinguished, which do not necessarily represent consecutive stages. Recent findings indicate in the pathogenesis of rosacea the role of the impaired innate immune system and vascular abnormalities. Additionally, the role of genetic and infectious factors is suggested. The therapy of rosacea is directed not only against inflammatory changes but also anti-parasitic. In topical treatment the most commonly used are metronidazole and azelaic acid. Other drugs are topical antibiotics, antiparasitic agents such as ivermectin and preparations directly influencing erythema. In more severe cases tetracyclines or macrolides are used, and in the most severe cases, isotretinoine. As ultraviolet light is a recognized trigger for rosacea, regular sunscreen use is necessary. Also, proper diet is indicated. Presently in the treatment of rosacea more and more techniques using different lights are employed.

  14. Demodex gatoi -associated contagious pruritic dermatosis in cats - a report from six households in Finland

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    Rajaniemi Riitta-Liisa

    2009-10-01

    Full Text Available Abstract Background Demodex gatoi is unique among demodectic mites. It possesses a distinct stubby appearance, and, instead of residing in the hair follicles, it dwells in the keratin layer of the epidermis, causing a pruritic and contagious skin disease in cats. Little is known of the occurrence of D. gatoi in Europe or control of D. gatoi infestation. Case presentation We describe D. gatoi in 10 cats, including five Cornish Rex, two Burmese, one Exotic, one Persian and one Siamese, living in six multi-cat households in different locations in Finland containing 21 cats in total. Intense pruritus was the main clinical sign. Scaling, broken hairs, alopecia and self-inflicted excoriations were also observed. Diagnosis was based on finding typical short-bodied demodectic mites in skin scrapings, skin biopsies or on tape strips. Other pruritic skin diseases, such as allergies and dermatophytoses, were ruled out. In one household, despite finding several mites on one cat, all six cats of the household remained symptomless. Amitraz used weekly at a concentration of 125-250 ppm for 2-3 months, proved successful in three households, 2% lime sulphur weekly dips applied for six weeks in one household and peroral ivermectin (1 mg every other day for 10 weeks in one household. Previous trials in four households with imidacloprid-moxidectin, selamectin or injected ivermectin given once or twice a month appeared ineffective. Conclusion D. gatoi-associated dermatitis is an emerging contagious skin disease in cats in Finland. Although pruritus is common, some cats may harbour the mites without clinical signs. In addition, due to translucency of the mites and fastidious feline grooming habits, the diagnosis may be challenging. An effective and convenient way to treat D. gatoi infestations has yet to emerge.

  15. [Topical treatment of various dermatosis with difluocortolone valerianate. (ointment) Double blind comparative study].

    Science.gov (United States)

    Cavajal Rosado, V M

    1976-01-01

    The trial preparation, diflucortolone valerate, was tested clinically in the form of fatty ointment on 27 patients: 4 with psoriasis, 4 with neurodermatitis, 4 with contact dermatitis, 2 with actinodermatitis, 10 with eczema, 2 with cutaneous reticulosis and 1 with radiodermitis. In 89% of the cases the results were good; in 11% were they regular.

  16. Acquired perforating dermatosis associated with hepatic failure in a liver-transplanted patient

    OpenAIRE

    Badziak, Daniela; Lenhardt, Carolina; Barros, Michele F. de; Mandelli, Fernando Luiz; Serafini, Sérgio Zuñeda; Santamaria, Jesus Rodriguez

    2007-01-01

    A dermatose perfurante adquirida é entidade clinicopatológica caracterizada por eliminação transepitelial de material dérmico degenerado, ocorrendo em muitas condições, entre elas diabetes mellitus, insuficiência renal crônica e colangite esclerosante. Relata-se o caso de paciente de 17 anos, com dermatose perfurante adquirida associada à insuficiência hepática crônica, conseqüente à complicação hepática de transplante de fígado para tratamento de sua doença de base, a glicogenose tipo I.Acqu...

  17. An old woman with chronic palmar dermatosis, rheumatism, and nail changes

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    Vitorino Modesto dos Santos

    2017-02-01

    Full Text Available Psoriasis is a chronic inflammatory condition with variable changes on the skin and nails, sometimes associated with osteoarticular manifestations characterizing the psoriatic arthritis. This arthritis may precede, follow, or be concomitant with the skin lesions of psoriasis. Unsuspected psoriatic arthritis may be misdiagnosed by other seronegative spondyloarthritis, mainly in primary care attention, and ominous outcomes are related to late and inadequate management. Therefore, diagnostic exercises with base on significant clinical and radiological images might contribute to enhance the suspicion index about these challenging conditions.

  18. Dermatose responsiva à biotina em cão Dermatosis responsive to Biotin in a dog

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    Sandra Prudente Nogueira

    2010-03-01

    Full Text Available Os transtornos da pele e dos pelos são parte importante na prática clínica de pequenos animais. Numerosos fatores nutricionais afetam a homeostase, a qualidade e o aspecto da pelagem. As vitaminas do complexo B incluem compostos hidrossolúveis necessários como coenzimas em diversas funções celulares envolvidas no metabolismo energético e na síntese tecidual. A biotina, em especial, é necessária nas reações de carboxilação, participando da síntese de ácidos graxos, aminoácidos e purinas pelo tecido epitelial. Uma cadela com quadro de cistite recorrente e tumor venéreo transmissível foi tratada com antibioticoterapia prolongada e quimioterapia. Após alguns meses de tratamento, foram observadas lesões no plano nasal e nos coxins plantar e palmar, caracterizadas por hiperceratose, espessamento, fissuras, sangramento e inflamação. O paciente recebeu suplementação de 15mg de biotina por via oral (equivalente a 1,4mg kg-1 de peso corporal, uma vez por dia, durante 60 dias, havendo importante regressão das lesões. Sugere-se que, sob antibioticoterapia e doença, a síntese intestinal de biotina possa não ter sido suficiente, sendo necessária sua suplementação.Skin and hair diseases are an important part in small animal's clinical practice. Many nutritional factors can affect the quality and the aspect of the coat. B complex vitamins are water-soluble compounds used as coenzymes in several cellular functions that are involved in energy metabolism and tissue synthesis. Biotin, in particular, is necessary for carboxylation reactions, fatty acids synthesis, and incorporation of essential amino acids and purines in the epithelial tissue. A female canine with recurrent cystitis and sticker tumor was treated chemotherapy and prolonged antibiotic therapy. After a few months of medications, lesions were observed in nasal plan and palmar and plantar pads, characterized by hyperkeratosis, skin thickness, bleeding fissures, and inflammation. The patient was treated with 15mg of oral biotin supplementation (1.4mg kg-1 of body weight once a day, for 60 days, with significant regression of skin lesions at the end of this period. These findings suggest that in certain diseases and particularly in prolonged antibiotics therapy, intestinal biotin synthesis may not be adequate, demanding oral supplementation.

  19. Linear IgA Bullous Dermatosis Secondary to Infliximab Therapy in a Patient with Ulcerative Colitis.

    Science.gov (United States)

    Hoffmann, Jochen; Hadaschik, Eva; Enk, Alexander; Stremmel, Wolfgang; Gauss, Annika

    2015-01-01

    Linear IgA bullous disease (LABD) is a rare vesiculobullous autoimmune skin disorder whose etiology and pathogenesis are not completely understood. Its occurrence has been related to malignancies, inflammatory diseases and several drugs. This report describes a 49-year-old Caucasian male with a 14-year history of ulcerative colitis who received infliximab to treat the refractory course of his bowel disease. During induction therapy with infliximab, he developed LABD. Treatment with infliximab was discontinued, and the skin lesions were successfully treated with oral steroids and dapsone. Considering the close chronological relation between administration of the tumor necrosis factor-α inhibitor and onset of the skin disease, we hypothesize that this is the first reported case of infliximab-induced LABD. Similar to psoriasis, it may represent a 'paradoxical' autoimmune reaction triggered by anti-tumor necrosis factor-α therapy.

  20. Azathioprine Hypersensitivity Syndrome: Two Cases of Febrile Neutrophilic Dermatosis Induced by Azathioprine

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    Majed Aleissa

    2017-01-01

    Full Text Available Background: Azathioprine is an immunosuppressive agent used in the treatment of immune-mediated diseases. Azathioprine hypersensitivity syndrome is a rare adverse reaction occurring a few days to weeks after the administration of azathioprine. Case 1: A 36-year-old male with ulcerative colitis presented with erythematous plaques, pustules and erosions on the lower back, buttocks and thighs associated with high fever (39°C 2 weeks after the initiation of azathioprine 100 mg/day. Additional findings included leukocytosis (18.6 g/L with neutrophilia (11.1 g/L and elevated C-reactive protein (128 mg/L. Histopathology showed a dense infiltrate of neutrophils in the hair follicles. We increased the dose of prednisone to 1 mg/kg/day (60 mg/day and azathioprine was discontinued. He had marked improvement within 3 weeks and did not have any relapse with a 1-year follow-up. Case 2: A 57-year-old male with ulcerative colitis presented with erythematous plaques and pustules on the lower limbs associated with high fever (40°C 1 week after the initiation of azathioprine 75 mg/day. Leukocytosis with neutrophilia (13.6 g/L and elevated C-reactive protein (344 mg/L were among the laboratory findings. Histopathology showed a dense infiltrate of neutrophils in the hair follicles. The dose of prednisone was increased to 20 mg/day and azathioprine was discontinued, which led to complete remission within 7 days. He did not have any relapse with a 6-month follow-up. Conclusion: The development of acute neutrophilic dermatitis 2 weeks after the initiation of azathioprine and the complete resolution after its withdrawal were in favor of azathioprine hypersensitivity syndrome. It should not be confused with Sweet syndrome associated with inflammatory bowel disease, as maintenance of azathioprine treatment may lead to life-threatening reactions.

  1. Impetigo herpetiformis occurring during N-butyl-scopolammonium bromide therapy in pregnancy: case report.

    Science.gov (United States)

    Guerriero, C; Lanza Silveri, S; Sisto, T; Rosati, D; De Simone, C; Fossati, B; Pomini, F; Rotoli, M; Amerio, P; Capizzi, R

    2008-01-01

    Impetigo herpetiformis (IH) is a rare dermatosis arising during the third trimester of pregnancy which is generally considered as a form of pustular psoriasis of unknown aetiology. Clinically it is characterized by erythematous plaques surrounded by sterile pustules associated with fever, diarrhea, sweating and increasing risk of stillbirth for placental insufficiency. We describe a case of developed erythematous plaques surrounded by pustules localised initially to the trunk of a 35-year-old woman at the 34th week of gestation after 5 days of treatment with N-Butyl-Scopolammonium, and which later involved the upper and lower limbs. Skin histology confirmed the diagnosis of generalised pregnancy pustular psoriasis (impetigo herpetiformis). IH is reported to be associated with hypocalcemia, hypoparathyroidism, use of oral contraceptives and bacterial infections. This is the first report suggesting the potential role of drugs other than oral contraceptives in the pathogenetic mechanism of this disease. In this case an adverse cutaneous reaction to BB could be the cause of the development of Koebner isomorphism.

  2. Early and Late Onset Side Effects of Photodynamic Therapy

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    Francesco Borgia

    2018-01-01

    Full Text Available Photodynamic Therapy (PDT is a non-invasive treatment successfully used for neoplastic, inflammatory and infectious skin diseases. One of its strengths is represented by the high safety profile, even in elderly and/or immuno-depressed subjects. PDT, however, may induce early and late onset side effects. Erythema, pain, burns, edema, itching, desquamation, and pustular formation, often in association with each other, are frequently observed in course of exposure to the light source and in the hours/days immediately after the therapy. In particular, pain is a clinically relevant short-term complication that also reduces long-term patient satisfaction. Rare complications are urticaria, contact dermatitis at the site of application of the photosensitizer, and erosive pustular dermatosis. Debated is the relationship between PDT and carcinogenesis: the eruptive appearance of squamous cell carcinoma (SCC in previously treated areas has been correlated to a condition of local and/or systemic immunosuppression or to the selection of PDT-resistant SCC. Here we review the literature, with particular emphasis to the pathogenic hypotheses underlying these observations.

  3. Análise da Composição Cianobacteriana das Esteiras Pustulares em Salina, Araruama, Rio de Janeiro.

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    Loreine Hermida da Silva e Silva

    2007-07-01

    Full Text Available Julieta saline receives water from lagoa de Araruama, which is located in the state of Rio de Janeiro, to the East of the city of Araruama and to the west of the city of Cabo Frio, between 22o 49’ and 22o 57’ S latitude and 42o 00’ and 42o 23’ W longitude. It is composed by a series of soil tanks obtained by natural excavation, where water gradually concentrates through natural evaporation until salt precipitation. The reservoirs can be divided in three types, according to their activity: cargo, evaporator and crystallizer tanks. The process of making such reservoirs waterproof is enabled bya fine layer of algae which is formed naturally with the passing of time. This study is based on monthly collects within the period ranging from May, 2004 to October, 2004, along three collection stations set up in different saline reservoirs. To identify the microbic composition, fresh, semi-permanent and permanent laminae were obtained and their analysis were performed by means of optical microscopy. The analysis revealed a total of twenty cyanobacterial types. In all layers, a predominant amount of oval spherical forms was observed. The predominance of cyanobacteria is justified by the fact that they are carriers of high morphological adaptations which enables them to survive in various types of environments andbe predominant in hypersaline sites.

  4. Psoríase pustulosa da infância: relato de caso Childhood pustular psoriasis: case report

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    Yuri Nogueira Chaves

    2010-12-01

    Full Text Available A psoríase pustulosa generalizada é tipo raro de psoríase descrita pela primeira vez, em 1910, por Von Zumbusch. A psoríase pustulosa generalizada na criança tende a ter um curso mais benigno que no adulto, entretanto, em sua forma grave, pode por em risco a vida do paciente. Talvez, pela raridade da doença, nenhuma opção terapêutica se mostrou consistentemente eficaz e segura até o momento. Relatos isolados sugerem ser o retinoide a droga de escolha nesses casos, porém trata-se de fármaco que, na primeira infância, traz mais dificuldades no manejo. Relata-se exemplo dessa rara doença em lactente, quadro extenso e grave, com resposta satisfatória ao uso de dapsona, com boa tolerabilidade.Generalized pustulous psoriasis is a rare type of psoriasis first described in 1910 by Von Zumbusch. This disease tends to have a more benign development in children when compared to its development in adults. However, in its serious form it may represent a risk to the patient's life. Maybe, due to being such a rare disease no therapeutic option has so far consistently proved to be both effective and safe. Isolated reports suggest that retinoid is the best choice of drug in these cases. However, it is difficult to manage this drug in early infancy. The present report describes a serious case of this rare disease in an infant with a satisfactory response and good tolerance to the use of dapsone.

  5. Case for diagnosis Caso para diagnóstico

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    Kleyton de Carvalho Mesquita

    2012-12-01

    Full Text Available Pyodermatitis-pyostomatitis vegetans is a rare mucocutaneous dermatosis characterized by pustular and vegetating lesions of the skin and oral mucosa. It is considered a highly specific marker for inflammatory bowel diseases. The authors describe a case of pyodermatitis-pyostomatitis vegetans in a pediatric patient who presented marked clinical improvement after beginning treatment with oral corticosteroids, azathioprine, and dapsone. Bowel surveillance is mandatory, since the dermatosis is associated with inflammatory bowel diseases in more than 70% of patients, especially ulcerative colitis.A piodermatite-pioestomatite vegetante é uma dermatose mucocutânea rara, caracterizada por lesões pustulosas e vegetantes na pele e mucosa oral. É considerada um marcador altamente específico para doenças intestinais inflamatórias. Os autores descrevem um caso de piodermatite-pioestomatite vegetante em paciente pediátrico, o qual apresentou boa resposta a corticoterapia oral associada à azatioprina e à dapsona. A vigilância intestinal é mandatória, uma vez que a dermatose está associada a doenças intestinais inflamatórias em mais de 70% dos casos, especialmente a colite ulcerativa.

  6. Dinotefuran/pyriproxyfen/permethrin pemphigus-like drug reaction in three dogs.

    Science.gov (United States)

    Bizikova, Petra; Moriello, Karen A; Linder, Keith E; Sauber, Leslie

    2015-06-01

    Pemphigus foliaceus (PF) can occur spontaneously or as a reaction pattern associated with cutaneous adverse drug reactions. To provide clinical, histological and immunological assessments of three dogs that developed cutaneous adverse drug reactions following application of a topical flea and tick control product, which contained dinotefuran, pyriproxyfen and permethrin. Three client-owned dogs. The dogs exhibited rapid onset of papules, pustules and crusts at the site of application of the flea control product. In two dogs, the lesions became generalized, while the third exhibited a localized phenotype. Both dogs with generalized lesions required immunosuppressive treatment; one achieved remission after 1 year of treatment and one was euthanized due to adverse effects of glucocorticoids. The dog with a localized phenotype was treated with topical glucocorticoids exclusively and achieved remission after 10 months. Histology revealed subcorneal pustular dermatitis, with acantholysis of keratinocytes and focal to multifocal full-thickness epidermal necrosis. These features are similar to those previously reported for pesticide-triggered and spontaneous PF. Tissue-bound IgG was detected in two of three dogs, and autoantibodies targeting canine desmocollin-1 were identified in the serum of the one dog from which a sample was available. Cutaneous adverse drug reaction caused by a flea control product containing dinotefuran, pyriproxyfen and permethrin closely resembled those reported for other pesticide-associated PF-like cutaneous adverse drug reactions. Although it appears to be a rare entity, clinicians and pathologists should be aware of the potential for flea and tick control products to trigger PF-like reactions. © 2015 ESVD and ACVD.

  7. Ulcerative dermatosis of the Shetland sheepdog and rough collie dog may represent a novel vesicular variant of cutaneous lupus erythematosus.

    Science.gov (United States)

    Jackson, H A; Olivry, T

    2001-02-01

    A syndrome of ulcerative dermatitis (UDSSC) previously has been described as unique to the Shetland sheepdog and rough collie dog. The pathogenesis of this disease is poorly understood and it has been suggested that it may be a variant of canine dermatomyositis (DM) which is also seen in these breeds. Information on the clinical presentation and previous medical history was collected from five Shetland sheepdogs and three rough collie dogs previously diagnosed with UDSSC. Characteristic features of the disease were adult onset in the summer months with annular, polycyclic and serpiginous ulcerations distributed over sparsely haired areas of the body. Skin biopsies taken from active lesions were compared in a blinded fashion with histological sections from seven Shetland sheepdogs and one rough collie with DM. Dermatomyositis was characterized histologically as a cell poor interface dermatitis associated with follicular atrophy. In contrast, the lesional pattern of UDSSC is that of a lymphocyte-rich interface dermatitis and folliculitis with vesiculation at the dermal-epidermal junction. The authors conclude that these represent two distinct diseases and that UDSSC may be a vesicular form of cutaneous lupus erythematosus seen in the adult rough collie dog and Shetland sheepdog.

  8. Pattern Of Dermatosis Among Pediatric Patients Attending A Medical College Hospital In North-Eastern Region Of India

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    Huda M . M

    2004-01-01

    Full Text Available A total of 500 children from first day of life to twelve completed years of age attending Dermatology OPD of Assam Medical College Hospital were analyzed for pattern of cutaneous disorders and modalities of pre-hospital care received. School- age children formed the major segment (45.0% followed by pre-school age children (37.8%. Infective dermatoses were 632% and non-infective 34.4%. Bacterial infections (34.4%, eczema (13.6% scabies(11.8%, fungal infections (8.8%, nutritional dermatoses(7.8%, pediculosis (3.8%, viral infections (2.2%, urticaria (2%, and a miscellaneous group comprising of twenty four categories (8% were seen. About 65% had not received any treatment prior to attending hospital. Those who received pre-hospital treatment includes self-medication 18.8%, treatment from primary care physician 7.8%, from pediatrician 3.6%, herbal applications 3%, rituals by faith healers 1.6 %, and treatment from dermatologists was only 0.4%.

  9. Acute febrile neutrophilic dermatosis (Sweet's syndrome in a child, associated with a rotavirus infection: a case report

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    Makis Alexandros

    2010-08-01

    Full Text Available Abstract Introduction Sweet's syndrome characterized by fever, blood neutrophilia and inflammatory skin lesions, is rarely diagnosed in children. It presents in three clinical settings: classical Sweet's syndrome, usually after a respiratory tract infection; malignancy-associated, frequently related to acute myelogeneous leukemia; and drug-induced. We present, to the best of our knowledge, the first case of a rotavirus -infection-related Sweet's syndrome. Case presentation An 18-month-old boy of Hellenic origin was referred to us with diarrhea, fever, neutrophilia, typical skin lesions, asymmetrical hip arthritis and oropharyngeal involvement. A skin biopsy confirmed the diagnosis. Thorough screening did not reveal any underlying systemic illness, except for the confirmation of an overt rotavirus infection. The syndrome responded promptly upon corticosteroid administration; no recurrence was observed. Conclusion Besides describing the connection of Sweet's syndrome to a rotavirus infection, this case report is also a reminder that in a child presenting with a febrile papulo-nodular rash with neutrophilia Sweet's syndrome should be included in the differential.

  10. Human papilloma virus dermatosis in human immunodeficiency virus-positive patients: A 14-year retrospective study in 965 patients.

    Science.gov (United States)

    Nuno-Gonzalez, Almudena; Losa Garcia, Juan Emilio; López Estebaranz, José Luis; Martin-Rios, María Dolores

    2017-05-10

    The incidence of the human papilloma virus (HPV) has not dropped in HIV-positive patients despite the discovery of antiretroviral therapy (ART). Our goal is to assess the prevalence of HPV in HIV patients and its relationship with the epidemiological and virological characteristics of HIV patients. Retrospective cohort of 965 patients diagnosed with HIV from 1998 to 2012. We analyzed patients' demographic factors and factors related to the HPV. Of the 965 patients examined, 333 consulted a dermatologist. Of these, 52 patients had genital warts (15.6%), 43 had common warts (12.9%) and 8% had both conditions. In total, 28.5% of patients had a skin lesion caused by HPV. This is the first longitudinal observational study carried out on HIV-positive patients in the era of ART in which HPV infection is the most common skin pathology. We observed a similar trend in countries with access to ART. This study spreads awareness on the importance of preventing HPV and the difficulty of treating it in HIV-positive patients. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

  11. [Impetigo herpetiformis (two cases)].

    Science.gov (United States)

    Masmoudi, A; Abdelmaksoud, W; Ghorbel, S; Amouri, H; Mseddi, M; Bouassida, S; Zahaf, A; Guermazi, M; Boudaya, S; Turki, H

    2008-12-01

    The hepetiformis impetigo is a pustulosis dermatosis. It is rare and specific to pregnancy. It can menace the prognostic of the mother and the child. This entity is actually considered as a pustulor psoriasis. We report two cases. Two patients, respectively, aged 24 and 21, presented erythematous, pustular and extensive plaques for which the diagnosis of hepetiformis impetigo was clinically and histologically posed. For the first patient, the lesions appeared in the two pregnancies and were more severe and foetal repercussions (oligoamnios and hypotrophy) during the second pregnancy. For the second patient, the pregnancy was complicated with premature interruption of the membrane, giving birth to a deed fetus and causing an aggravation of the cutaneous lesions. The treatment was oral steroid followed by acitretin for the first patient, however, for the second patient; the treatment was by local steroid associated with UVB during the pregnancy. Then, acitrétine was used and was efficient. Our two cases show the importance of gynaecological control in order to avoid complications which can be sometimes fatal. They also show the importance of local steroid associated with UVB which constitute another therapeutic alternative in the treatment of hepetiformis impetigo.

  12. Non-dermatophyte Dermatoses Mimicking Dermatophytoses in Animals.

    Science.gov (United States)

    Pin, Didier

    2017-02-01

    Dermatophytoses in animals are fungal diseases of the skin caused by dermatophyte fungi of the genus Microsporum or Trichophyton. Because the infection is generally follicular, the most common clinical sign is one or many circular areas of alopecia with variable erythema, scaling and crusting, and the primary differential diagnoses are follicular infections, such as bacterial folliculitis and demodicosis. Although dermatophyte folliculitis or ringworm is the most commonly observed lesion of dermatophytoses in animals, other presentations may be observed according to the host species and the dermatophyte involved: dermatophyte folliculitis or ringworm, scaling and crusting in dermatophytosis due to Microsporum persicolor, nodule in case of kerion or mycetoma, matted hairs, seborrheic dermatosis or miliary dermatitis in cats, generalized exfoliative dermatoses in dogs, cats and horses, superficial non-follicular pustules, papules and macules in the Devon Rex cat, pruritic dermatophytoses in dogs, cats and horses, and onychomycosis in dogs, cats and horses. Since manifestations of dermatophytosis are highly variable, particularly in the cat, dermatophytosis should be considered in case of any annular, papular, nodular or pustular dermatoses, alopecic or not, sometimes pruritic, and nodular dermatoses as well.

  13. Evalution of Clinical and Sociodemograpic Features of Patients with Psoriasis in the Konya Region

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    Caner Aykol

    2011-11-01

    Full Text Available Objective: Psoriasis is a chronic inflammatory dermatosis with silvery-white coloured squamas and is characterized by erythematous papules and plaques. Psoriasis is seen in 1-2% of the normal population. In this study we aim to introduce the clinical and demographic features of patients with psoriasis in our region.Materials and Methods: 640 patients being followed in our psoriasis polyclinic between May 2006 and April 2010 were evaluated retrospectively.Results: Patients diagnosed with psoriasis constituted the 0.7% who visited our polyclinic. Three hundred and twenty one of the patients were female and 319 were male. A history of psoriasis was observed in at least one of the first or second degree relatives of 25.6% of patients with psoriasis. The most common concomitant disease in patients was hypertension. 97.6% of the patients had psoriasis vulgaris and 2.34% had pustular psoriasis. Nail involvement and psoriatic arthritis were detected in 37.6% and 5.62% of the patients.Conclusion: In our study, the clinical and sociodemographic features of psoriasis is found to be similar to other studies carried out in Turkey and in European societies. Female/Male ratio is equal.The most prevalent psoriasis type is plaque type and the most frequent nail finding is pitting. The onset of the disease is more widespread in the third decade. The most common comorbidity is hypertension.

  14. Off-label use of TNF-alpha inhibitors in a dermatological university department

    DEFF Research Database (Denmark)

    Sand, Freja Lærke; Thomsen, Simon Francis

    2015-01-01

    ), chronic urticaria (25), hidradenitis suppurativa (29), acne conglobata (11), dissecting cellulitis of the scalp (two), orofacial granulomatosis (four), sarcoidosis (four), granuloma annulare (two), granulomatous rosacea (one), granuloma faciale (one), subcorneal pustulosis (one), pyoderma gangrenosum...

  15. Prevalência de dermatoses em escolares na região do ABC paulista Prevalence of dermatosis in scholars in the region of ABC paulista

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    Cristina Marta Maria Laczynski

    2011-06-01

    Full Text Available FUNDAMENTOS: A literatura mostra que a prevalência de doenças dermatológicas em crianças e adolescentes com idades de 7-14 anos é consideravelmente significante, bem como a falta de tratamento e possível agravamento da situação. OBJETIVOS: Realização de uma análise investigativa para apontar a prevalência de dermatoses em indivíduos de 714 anos, assim como para verificar se estas estão diretamente ligadas ou não a suas respectivas situações socioeconômicas. MÉTODOS: Analisaram-se 200 crianças e adolescentes com idades de 7-14 anos, entre os meses de agosto e novembro de 2006, sendo 100 crianças em duas escolas públicas localizadas na periferia e 100 em duas escolas particulares localizadas em bairro de classe média alta na cidade de Santo André, Grande São Paulo. Para tanto, utilizou-se o método investigativo, com exame clínico de toda a superfície corpórea, de mucosas e de gânglios palpáveis, sendo a amostra populacional analisada de acordo com o teste qui-quadrado. RESULTADOS: 87,5% das crianças apresentaram algum tipo de dermatose; encontraram-se 46 dermatoses, destacando-se: a nevos melânicos (pBACKGROUND: Literature shows that prevalence of skin diseases in children and adolescents aged 7-14 years is very significant, as well as lack of treatment worsening the situation. OBJECTIVES: An investigative analysis was conducted to determine the prevalence of skin diseases in individuals 714 years and focus on whether or not they are related directly to their respective socio-economic status. METHODS: 200 children and adolescents were examined aged 7-14 years,between August and November 2006,100 children in two public schools located in the periphery and 100 in two private schools located in upper middleclass neighborhood in Santo André,located in São Paulo.Investigative method used was the clinical examination of the whole skin, mucous areas and palpable ganglia,and the population sample analyzed according to the chi-square. RESULTS: 87.5% of children had some skin disease.46 dermatoses were found,the most important:amelanocytic nevi (p <0.001;bacne grade II (p = 0.004;cpityriasis alba (p <0.001;dlivedo reticularis (p = 0.025; epediculosis (p <0.001;fasteatosis (p <0.001;g frictional dermatitis (p = 0.007.Small prevalence of skin diseases was observed in children in public schools (53.14%. CONCLUSIONS: This population sample indicated that 87.5% of children had skin diseases,which prevalence was much higher than those found in the literature(30-50%,showing a lightly enhanced prevalence in public schools.The study showed the neglect of parents and caregivers,indicating the need for interference from public policy,which lack certainly is responsible for high rate and can increase it

  16. Mast-cell interleukin-1beta, neutrophil interleukin-17 and epidermal antimicrobial proteins in the neutrophilic urticarial dermatosis in Schnitzler's syndrome

    NARCIS (Netherlands)

    Koning, H.D. de; Vlijmen-Willems, I.M.J.J. van; Rodijk-Olthuis, D.; Meer, J.W.M. van der; Zeeuwen, P.L.J.M.; Simon, A.; Schalkwijk, J.

    2015-01-01

    BACKGROUND: Schnitzler's syndrome (SchS) is an autoinflammatory disease characterized by a chronic urticarial rash, a monoclonal component and signs of systemic inflammation. Interleukin (IL)-1beta is pivotal in the pathophysiology. OBJECTIVES: Here we investigated the cellular source of

  17. Dermatose por IgA linear induzida pela gestação Linear IgA dermatosis induced by pregnancy

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    Telma Kanagusuko

    2008-02-01

    Full Text Available A dermatose por IgA linear é doença bolhosa auto-imune subepidérmica rara, caracterizada pelo depósito linear de IgA na zona da membrana basal da epiderme. Nos relatos de gestação em pacientes com essa dermatose, nota-se sempre melhora do quadro clínico. Contrariando essas observações,é apresentado caso de dermatose por IgA linear induzida pela gestação, que demonstrou boa resposta terapêutica à dapsona e prednisona , sem complicações materno-fetais.Linear IgA disease is a rare autoimmune subepidermal bullous disorder characterized by linear IgA deposits at the epidermal basement membrane zone. According to the literature, in patients who have linear IgA disease and become pregnant, the disease tends to improve. We report a case of linear IgA disease induced by pregnancy, successfully treated with dapsone and prednisone with no adverse effects observed in the patient and her newborns.

  18. Bullous pemphigoid and linear IgA dermatosis sera recognize a similar 120-kDa keratinocyte collagenous glycoprotein with antigenic cross-reactivity to BP180

    NARCIS (Netherlands)

    Pas, HH; Kloosterhuis, GJ; Heeres, K; vanderMeer, JB; Jonkman, MF

    Circulating IgG from a large subset of bullous pein; phigoid (SP) patients reacted on immunoblot with a 120-kDa protein in conditioned keratinocyte culture medium and in keratinocyte cell extracts, A protein with a similar molecular weight was recognized by circulating IgA from a subset of patients

  19. Histopathological aspects of neutrophilic dermatoses: Investigation of 38 cases and review of the literature

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    Amir-Hoshang Ehsani

    2016-01-01

    Full Text Available Introduction: Neutrophilic dermatosis (ND is a heterogeneous group of diseases with various etiologies and clinical presentations. NDs may clinically present as papule, vesiculopustule, plaque, and nodule of the skin, but they all share the common feature of neutrophilic predominance in the skin. Histological examination of patients with suspected ND is a key step for making the proper diagnosis. Patients and Methods: The aim of this article was to investigate histopathological aspects of different NDs. We obtained our data from medical records of patients at Razi dermatology hospital, between 2012 and 2014. Thirty-eight biopsy records coded under the term of any ND, including Sweet's syndrome (SS, pyoderma gangrenosum (PG, skin lesions of Behcet's disease, neutrophilic drug eruption, amicrobial pustulosis of the folds, pustular vasculitis of the hands, and undetermined ND were recruited in our study. The specimens were evaluated regarding inflammatory reaction pattern, epidermal/adnexal changes, and dermal changes. Results: Most common NDs in our study were PG (42.1% followed by SS (21.1%. The most common pattern of inflammatory reaction was superficial perivascular and interstitial dermal inflammation in 44.7% of the patients. Exocytosis of neutrophils into epidermis, hair follicle, and eccrine gland was seen in 71%, 18.5%, and 28.9% of the specimens, respectively. Ulceration was only seen in ten PG specimens. Dermal fibrosis and vascular proliferation were reported in all PG patients. Conclusion: The prevalence of some histopathological findings in different types of ND was significantly different. These features seem helpful in distinguishing between different NDs.

  20. Piodermatite-pioestomatite vegetante: relato de caso e revisão de literatura Pyodermatitis-pyostomatitis vegetans: case report and review of medical literature

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    Fernanda de Abreu Toledo Matias

    2011-08-01

    Full Text Available A piodermatite-pioestomatite vegetante é uma rara dermatose inflamatória de etiologia desconhecida, com típico comprometimento mucocutâneo. Relatamos caso de paciente feminina com lesões pustulosas e vesiculosas em axilas, evoluindo com placas vegetantes e pústulas com agrupamento anular. Houve progressão com comprometimento vulvar, inguinal e mucosas oral, nasal e ocular. Proposto o diagnóstico, optou-se por iniciar prednisona 40mg ao dia, com remissão das lesões após um mês de uso da medicação. A associação com doença inflamatória intestinal ocorre em 70% dos casos. A imunofluorescência é um fator que ajuda a caracterizar a doença, sendo tipicamente negativa. A rápida resposta à terapêutica com corticosteroides sistêmicos é esperadaPyodermatitis-pyostomatitis vegetans is a rare inflammatory dermatosis of unknown etiology, with a typical mucocutaneous involvement. We report the case of a woman with pustular and vesicular lesions in the axillae, evolving with vegetating plaques and pustules with annular grouping. The disease progressed with vulvar and inguinal involvement as well as involvement of the oral, nasal and ocular mucous membranes. She started the treatment with prednisone (40 mg/day, with remission of the lesions after one month of use of such medication. Association with inflammatory bowel disease occurs in 70% of the cases. Immunofluorescence, which is typically negative, helps to characterize the disease. A rapid response to systemic steroids is expected

  1. Dermatoses entre os Xavánte da área indígena Pimentel Barbosa, Mato Grosso (Brasil Dermatosis among the Xavánte from the Pimentel Barbosa Indian Reservation, Mato Grosso, (Brazil

    Directory of Open Access Journals (Sweden)

    Rosicler R. Alvarez

    1991-12-01

    Full Text Available Os autores descrevem o resultado de inquérito dermatológico realizado entre os Xavánte da Área Indígena Pimentel Barbosa, Mato Grosso, Brasil. Os resultados indicam a ocorrência de doenças relacionadas à higiene inadequada, como a escabiose, pediculose e piodermite. O encontro de perlèche sugere deficiência nutricional O pênfigo foliáceo endêmico (fogo selvagem foi a afecção dermatológica de maior gravidade presente nesta população.The authors present the results of a dermatological survey conducted among the Xavánte Indians from the Pimentel Barbosa Reservation, state of Mato Grosso, Brazil Scabies, pediculosis, and pioderma were the most frequent diseases, clearly related to poor hygiene. The finding of perlèche indicates the presence of nutritional deficiency. Endemic pemphigus foliaceus (fogo selvagem was the most serious dermatological affection found in this population.

  2. Dermatose por IgA e IgG linear: relato de caso com boa resposta terapêutica à dapsona e ao micofenolato mofetil Linear IgA/IgG bullous dermatosis: successful treatment with dapsone and mycophenolate mofetil

    Directory of Open Access Journals (Sweden)

    Leny Passos

    2011-08-01

    Full Text Available Relata-se o caso de paciente feminina, de 21 anos, com dermatose por IgA e IgG linear. Inicialmente, a resposta clínica foi favorável à dapsona. Após a interrupção desta medicação, por crise de anemia sintomática, precipitada por malária, houve piora da doença, apesar da utilização da prednisona e pulsoterapia com metilprednisolona. A reintrodução da dapsona, associada ao micofenolato mofetil, possibilitou o controle da enfermidadeA 21-year-old female presenting linear IgA and IgG disease initially responded well to dapsone therapy. However, the treatment with dapsone was withdrawn due to severe anemia induced by malaria, which led to worsening of the clinical picture. Although prednisone and methylprednisolone were tried, the patient responded only to the association of dapsone and mycophenolate mofetil

  3. Cleansers and their role in various dermatological disorders

    National Research Council Canada - National Science Library

    Mukhopadhyay, Partha

    2011-01-01

    ... into it. In dermatological disorders like acne, rosacea, atopic dermatitis, photoaging, 'sensitive skin', occupational dermatosis cleansers may have a beneficial role along with other therapeutic measures...

  4. VACUNAS CONTRA EL HERPESVIRUS BOVINO-1: UNA MIRADA DESDE EL PASADO HACIA EL FUTURO DE LA INMUNIZACIÓN

    National Research Council Canada - National Science Library

    Julian Ruiz Saenz

    2009-01-01

    ...; la infección primaria se acompaña de varias manifestaciones clínicas tales como la rinotraqueitis, aborto, vulvovaginitis/balanopostitis pustular y en algunos casos, enfermedad neurológica...

  5. The spectrum of histopathological features in acute generalized exanthematous pustulosis : a study of 102 cases

    NARCIS (Netherlands)

    Halevy, S.; Kardaun, S. H.; Davidovici, B.; Wechsler, J.

    2010-01-01

    Background Acute generalized exanthematous pustulosis (AGEP) is a rare severe pustular reaction pattern with a typical clinical picture. Objectives To characterize the histopathological features of AGEP in a large series of cases with a validated diagnosis. Methods A multinational retrospective

  6. Ofuji's disease in an immunocompetent patient successfully treated with dapsone

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    Gopikrishnan Anjaneyan

    2016-01-01

    Full Text Available Eosinophilic pustular folliculitis or Ofuji's disease is a non-infectious eosinophilic infiltration of hair follicles, which usually presents with itchy papules and pustules in a circinate configuration. We report this case of an immunocompetent patient with erythematous papules and plaques without macropustules diagnosed as eosinophilic pustular folliculitis—a rarely reported entity outside Japan. He was successfully treated with oral dapsone.

  7. Sweet Syndrome After Autologous Stem Cell Transplant.

    Science.gov (United States)

    Alkan, Ali; İdemen, Celal; Okçu Heper, Aylin; Utkan, Güngör

    2016-02-01

    Sweet syndrome (acute febrile neutrophilic dermatosis) is a rare clinical entity characterized by skin lesions, neutrophilia, fever, and neutrophilic infiltration of the dermis. It may be a consequence of malignant disease, comorbidities, or drugs. We present a case of acute febrile neutrophilic dermatosis in a patient after autologous stem cell transplant.

  8. Dynamics of archaea at fine spatial scales in Shark Bay mat microbiomes

    Science.gov (United States)

    Wong, Hon Lun; Visscher, Pieter T.; White, Richard Allen, III; Smith, Daniela-Lee; Patterson, Molly M.; Burns, Brendan P.

    2017-04-01

    The role of archaea in microbial mats is poorly understood. Delineating the spatial distribution of archaea with mat depth will enable resolution of putative niches in these systems. In the present study, high throughput amplicon sequencing was undertaken in conjunction with analysis of key biogeochemical properties of two mats (smooth and pustular) from Shark Bay, Australia. One-way analysis of similarity tests indicated the archaeal community structures of smooth and pustular mats were significantly different (global R = 1, p = 0.1%). Smooth mats possessed higher archaeal diversity, dominated by Parvarchaeota. The methanogenic community in smooth mats was dominated by hydrogenotrophic Methanomicrobiales, as well as methylotrophic Methanosarcinales, Methanococcales, Methanobacteriales and Methanomassiliicoccaceae. Pustular mats were enriched with Halobacteria and Parvarchaeota. Key metabolisms (bacterial and archaeal) were measured, and the rates of oxygen production/consumption and sulfate reduction were up to four times higher in smooth than in pustular mats. Methane production peaked in the oxic layers and was up to seven-fold higher in smooth than pustular mats. The finding of an abundance of anaerobic methanogens enriched at the surface where oxygen levels were highest, coupled with peak methane production in the oxic zone, suggests putative surface anoxic niches in these microbial mats.

  9. Drug: D04755 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available Japan [BR:br08301] 2 Agents affecting individual organs 26 Epidermides 263 Suppurative dermatosis agents 2639 Others D04755 Bacitracin - fradiomycin sulfate mixt PubChem: 17398156 ...

  10. [INABILITY TO TOLERATE COSMETICS].

    Science.gov (United States)

    Piérard, G E; Piérard-Franchimont, C

    2016-05-01

    Inability to tolerate cosmetics can result from distinct mechanisms which appear as the so-called sensitive skin corresponding to one aspect of invisible dermatosis, or which corresponds to manifestations of a contact allergic or irritation dermatitis.

  11. Disease: H01179 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available nt C, Hervier B, Grossi O Tungiasis: a poorly documented tropical dermatosis. Med Mal Infect 41:465-8 (2011)...lected health problem of poor communities. Trop Med Int Health 6:267-72 (2001) PM

  12. SLC29A3 gene is mutated in pigmented hypertrichosis with insulin-dependent diabetes mellitus syndrome and interacts with the insulin signaling pathway.

    NARCIS (Netherlands)

    Cliffe, S.T.; Kramer, J.M.; Hussain, K.; Robben, J.H.; Jong, E.K. de; Brouwer, A.P.M. de; Nibbeling, E.; Kamsteeg, E.J.; Wong, M.; Prendiville, J.; James, C.; Padidela, R.; Becknell, C.; Bokhoven, J.H.L.M. van; Deen, P.M.T.; Hennekam, R.C.M.; Lindeman, R.; Schenck, A.; Roscioli, T.; Buckley, M.F.

    2009-01-01

    Pigmented hypertrichotic dermatosis with insulin-dependent diabetes (PHID) syndrome is a recently described autosomal recessive disorder associated with predominantly antibody negative, insulin-dependent diabetes mellitus. In order to identify the genetic basis of PHID and study its relationship

  13. SLC29A3 gene is mutated in pigmented hypertrichosis with insulin-dependent diabetes mellitus syndrome and interacts with the insulin signaling pathway

    NARCIS (Netherlands)

    Cliffe, Simon T.; Kramer, Jamie M.; Hussain, Khalid; Robben, Joris H.; de Jong, Eiko K.; de Brouwer, Arjan P.; Nibbeling, Esther; Kamsteeg, Erik-Jan; Wong, Melanie; Prendiville, Julie; James, Chela; Padidela, Raja; Becknell, Charlie; van Bokhoven, Hans; Deen, Peter M. T.; Hennekam, Raoul C. M.; Lindeman, Robert; Schenck, Annette; Roscioli, Tony; Buckley, Michael F.

    2009-01-01

    Pigmented hypertrichotic dermatosis with insulin-dependent diabetes (PHID) syndrome is a recently described autosomal recessive disorder associated with predominantly antibody negative, insulin-dependent diabetes mellitus. In order to identify the genetic basis of PHID and study its relationship

  14. Skin and hair changes during pregnancy

    Science.gov (United States)

    Dermatosis of pregnancy; Polymorphic eruption of pregnancy; Melasma - pregnancy; Prenatal skin changes ... breasts enlarge to prepare for breastfeeding. During your pregnancy, your stretch marks may appear red, brown, or ...

  15. Pyoderma Gangrenosum and lymph nodes tuberculosis disease: unusual association

    Directory of Open Access Journals (Sweden)

    Ines Zaraa

    2011-06-01

    Full Text Available Pyoderma gangrenosum (PG is a rare neutrophilic dermatosis with unknown etiology. PG associated with infectious disease is very unsual. We report a singular case of PG with lymph nodes tuberculosis disease.

  16. Laser Application In Photobiology And Photomedicine

    Science.gov (United States)

    Anders, Angelika

    1981-05-01

    Applications of lasers in photobiology and photomedicine will be reviewed; for example, genetic processes, photosynthesis, vision, spectroscopy of skin, phototherapy and photochemotherapy of dermatosis and tumors are considered. New results and future possibilities are discussed.

  17. Características clínicas y epidemiológicas de la escabiosis en tres consultorios del médico de la familia

    National Research Council Canada - National Science Library

    Chacón Cabrera, Ana I; Larrondo Muguercia, Rubén José; Cotán Morales, Ileana; Alacán Pérez, Lázara

    1998-01-01

    ... años y entre los obreros de nivel medio de escolaridad. Se identificaron lesiones elementales poco comunes y localizaciones no habituales de las lesiones para esta dermatosis. El mayor número de casos mejoró...

  18. Histopathological evaluation of the effects of fiber reinforced acrylic resins on living tissues.

    Science.gov (United States)

    Özdemir, Ali Kemal; Polat, Nilüfer Tülin; Turgut, Mehmet; Özdemir Dogan, Derya; Göze, Fahrettin

    2013-01-01

    The aim of this study was the histopathological evaluation of the effects of the fiber reinforced acrylic resins on living tissues. The study was performed on 21 rabbits. Three groups, each including seven subjects, were formed. There was no applied plate in the control group. For the second group, heat-polymerized acrylic resin plates were inserted. For the third group, heat-polymerized acrylic resin plates containing proportionally 5% chopped silanated E type glass fiber were inserted. Plates were fixed to the palatine bone of the rabbits with titanium screws. Before the implementation of the plates and 1 month after the plates were applied, soft tissue samples were taken from the buccal mucosa of the rabbits. Also, tissue samples were taken from the control group. All samples were evaluated histopathologically. In the control group, only a focal atrophy was observed. In the acrylic group, large decomposition containing erythrocytes under the parahyperkeratotic region and micro-vesicle like spongiotic tissue reactions were observed. In the fiber reinforced acrylic group, widespread focal atrophy, bulgy look of the epithelium cells similar to apoptosis, over-distension and sub-corneal decomposition had been observed. In terms of atrophy and hyperkeratosis there were no statistically significant differences among groups. However, in respect to sub-corneal decomposition, there was a statistically significant difference in the fiber reinforced group (p decomposition of the fiber reinforced group had made us think that fiber edges had a traumatic effect on the reaction.

  19. Fatores desencadeantes em dermatoses crônicas de crianças com perfis internalizante e externalizante segundo relato materno = Triggering factors in chronic dermatoses of children with internalizing and externalizing profiles according to maternal report = Los factores que se desencadenan en las dermatosis crónicas de los niños con perfiles de internalización y externalización según relato materno

    Directory of Open Access Journals (Sweden)

    Dias, Natália Guimarães

    2016-01-01

    Full Text Available Mães são responsáveis pelos cuidados com a saúde de crianças com dermatoses crônicas. Portanto, faz-se importante conhecer os eventos desencadeantes dos sintomas segundo avaliação materna e se há relação dessa atribuição com o tipo de doença e o perfil comportamental das crianças. Relatos de 13 mães de crianças clínicas (perfil internalizante e/ou externalizante do CBCL e com dermatite atópica, vitiligo ou psoríase foram analisados. Cinco categorias (fatores ambientais, biológicos e genéticos, situacionais, da interação da criança com mãe/pai e emocionais foram comparadas com (1 tipo de dermatose e (2 perfil da criança. Houve atribuição de fatores ambientais, biológicos e genéticos (dermatite atópica, situacionais, da interação com mãe/pai e emocionais (vitiligo. Fatores emocionais foram atribuídos às crianças avaliadas como clínicas para os dois perfis e para o internalizante apenas, mas não para o externalizante. Estes resultados podem auxiliar nas decisões médicas quanto ao tratamento e à pertinência da inclusão do acompanhamento psicológico

  20. A retrospective analysis of the infectious bovine rhinotracheitis (bovine herpes virus-1) surveillance program in Norway using Monte Carlo simulation models

    DEFF Research Database (Denmark)

    Paisley, Larry; Tharaldsen, J.; Jarp, J.

    2001-01-01

    Serological surveillance for antibodies against bovine herpes virus type I (BHV-1) which causes infectious bovine rhinotracheitis and infectious pustular vulvovaginitis has been carried out since 1992 in Norway. Since 1993 (when a single infected herd was detected) all bulk-milk and pooled...

  1. Dermatophilus congolensis human infection.

    Science.gov (United States)

    Towersey, L; Martins, E de C; Londero, A T; Hay, R J; Soares Filho, P J; Takiya, C M; Martins, C C; Gompertz, O F

    1993-08-01

    Four cases of human dermatophilosis observed in Rio de Janeiro, Brazil, are reported. Data that suggest nail infection by Dermatophilus congolensis are presented. The clinical spectrum of the disease ranged from an asymptomatic infection to a pustular eruption. Our findings suggest that epidermal Langerhans cells play a role in the pathogenesis of the infection.

  2. Atomic force microscopy of torus-bearing pit membranes

    Science.gov (United States)

    Roland R. Dute; Thomas Elder

    2011-01-01

    Atomic force microscopy was used to compare the structures of dried, torus-bearing pit membranes from four woody species, three angiosperms and one gymnosperm. Tori of Osmanthus armatus are bipartite consisting of a pustular zone overlying parallel sets of microfibrils that form a peripheral corona. Microfibrils of the corona form radial spokes as they traverse the...

  3. Sudanese Journal of Dermatology

    African Journals Online (AJOL)

    This is an unusual presentation of Pemphigus erythematosus in a 32- year old Sudanese male. The pustular eruption the patient presented with, guided to many differential diagnoses till the final diagnosis was reached. The case is presented here in details. Sudanese Journal of Dermatology Vol. 5 (1) 2007: pp. 36-39 ...

  4. Acute Generalized Exanthematous Pustulosis Due to Oral Use of Blue Dyes

    Science.gov (United States)

    Sener, Osman; Kose, Ösman; Safali, Mukerrem

    2011-01-01

    Acute generalized exanthematous pustulosis is a rare severe pustular cutaneous adverse reaction characterized by a rapid clinical course with typical histological findings. It is accompanied by fever and acute eruption of non-follicular pustules overlying erythrodermic skin. The causative agents are most frequently antibacterial drugs. We present a patient with acute generalized exanthematous pustulosis caused by methylene blue and indigotin dyes. PMID:22016599

  5. Putative contact ketoconazole shampoo-triggered pemphigus foliaceus in a dog.

    Science.gov (United States)

    Sung, Hyun-Jeong; Yoon, In-Hwa; Kim, Jung-Hyun

    2017-09-01

    A 10-year-old spayed female cocker spaniel dog was referred for an evaluation of acute-onset generalized pustular cutaneous lesions following application of ketoconazole shampoo. Cytologic and histopathologic examinations of the lesions revealed intra-epidermal pustules with predominantly neutrophils and acantholytic cells. This is the first description of putative contact ketoconazole shampoo-triggered pemphigus foliaceus in a dog.

  6. Colchicine in the treatment of type 2 lepra reaction.

    Science.gov (United States)

    Sharma, V K; Kumar, B; Kaur, I; Singh, M; Kaur, S

    1986-01-01

    Fifteen patients of lepromatous leprosy having type 2 lepra reaction were treated with colchicine. Seven had moderate, five mild and three had severe E.N.L., colchicine was found effective in all mild, six moderate and one case of pustular E.N.L.

  7. Pemphigus Erythematosus with an unusual presentation | El Agraa ...

    African Journals Online (AJOL)

    This is an unusual presentation of Pemphigus erythematosus in a 32- year old Sudanese male. The pustular eruption the patient presented with, guided to many differential diagnoses till the final diagnosis was reached. The case is presented here in details. Sudanese Journal of Dermatology Vol. 5 (1) 2007: pp. 36-39 ...

  8. [Clinical and epidemiologic aspects of paraneoplastic dermatoses in hospitalized patients treated at the Clinic for Dermatologic and Venereal Diseases in Novi Sad over a 10-year period (1980-1990)].

    Science.gov (United States)

    Stojanović, S; Poljacki, M; Dimoski, A; Tasić, S

    1995-01-01

    Authors report results of a retrospective investigation on frequency of paraneoplastic dermatoses, their clinical characteristics, time of onset and course regarding 10 - year material on hospitalized patients at the Clinic for Infectious and Dermatovenerous Diseases in Novi Sad. Out of 9086 hospitalized patients in 14 patients (0.16%) paraneoplastic dermatisis was diagnosed. Out of 14 patients in 5 patients (35.71%) Herpes zoster was diagnosed; in 4 patients (28.57%) bullous dermatosis; in 2 patients (14.29%) paraneoplastic acrokeratosis; in 1 patient (7.14%) exudative multiform erythema in 1 patient (7.14%) erythema figuratum and in one more patient necrotic Herpes labialis was diagnosed. Concerning malignant neoplasms of internal organs together with paraneoplastic dermatosis in most cases (4 - 28.57%) chronic lymphocyte leucosis was found, and in remaining 10 (71.43%) carcinomas were diagnosed at different internal organs. In 7 cases (50%) malignancy proceeded paraneoplastic dermatosis, in 4 cases (28.57%) the malignancy was diagnosed at the same time as paraneoplastic dermatosis and in 3 cases (28.43%) malignancy was established after the onset of paraneoplastic dermatosis. Authors point to the fact that usual skin changes, characteristic for the dermatologic diseases mentioned, in cases when they are associated with visceral malignomas, are characterized by a more serious clinical picture, a longer course of the disease and resistance concerning usual therapy.

  9. [Small cell lung cancer associated with paraneoplastic bullous pemphigoid].

    Science.gov (United States)

    Lakhdar, N; El Khattabi, W; Lahroussi, M; Afif, H; Aichane, A

    2014-06-01

    The broncho-pulmonary small cell carcinoma is the most common cancer provider paraneoplastic syndrome especially neurological and endocrine but also cutaneous syndrome. Paraneoplastic dermatosis do not result from a direct extension of cancer and are not metastases, but their presence is suggestive of an underlying tumor. The evolution of the dermatosis is parallel to that of cancer: treating cancer results in the regression of cutaneous manifestations. We report an observation of a 44-year-old smoker, who was hospitalized for a tissue excavated process associated with bullous dermatosis. The transmural puncture biopsy finds small cell carcinoma. The skin biopsy objective bullous pemphigoid. The evolution under chemotherapy was marked regression of bullous lesions and the patient died later after metastatic extension. Cutaneous paraneoplastic syndrome appears only in a minority of cancer patients, but its recognition is very important for early diagnosis. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  10. Acute generalized exanthematous pustulosis (AGEP): A review and update.

    Science.gov (United States)

    Szatkowski, Jesse; Schwartz, Robert A

    2015-11-01

    Acute generalized exanthematous pustulosis is a severe cutaneous adverse reaction characterized by the rapid development of nonfollicular, sterile pustules on an erythematous base. It is attributed to drugs in the majority of cases. Antibiotics are the most common cause of acute generalized exanthematous pustulosis; however, a wide variety of drugs has been associated with this condition. Typically, within 48 hours of ingesting the causative medication, there is acute onset of fever and pustulosis with leukocytosis. In severe cases there can be mucous membrane and systemic organ involvement. Histologic findings include intracorneal, subcorneal, and/or intraepidermal pustules with papillary dermal edema containing neutrophils and eosinophils. Treatment focuses on removal of the causative drug, supportive care, infection prevention, and the often beneficial use of a potent topical steroid. Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  11. Acute generalized exanthematous pustulosis.

    Science.gov (United States)

    Sidoroff, Alexis

    2012-01-01

    The key clinical features of acute generalized exanthematous pustulosis (AGEP) are the acute occurrence of numerous pinhead-sized nonfollicular sterile pustules on an edematous erythema accompanied by fever and leukocytosis. Histology shows mainly spongiform subcorneal and/or intraepidermal pustules, frequently a marked edema of the papillary dermis, neutrophils, and often eosinophils. AGEP is a reaction pattern mostly caused by drugs, the ones with the highest risk being antibacterial agents like ampicillin/amoxicillin, and quinolones, pristinamycin, anti-infective sulfonamides, the antimycotic drug terbinafine, (hydroxy)chloroquine, and diltiazem. In addition, a large number of other drugs as well as infections have been reported as triggers. AGEP is an acute and sometimes severe reaction. When the causative agent is withdrawn, it usually resolves quickly without specific treatment. Copyright © 2012 S. Karger AG, Basel.

  12. Intracorneal Hematoma Showing Clinical and Dermoscopic Features of Acral Lentiginous Melanoma

    Directory of Open Access Journals (Sweden)

    Ugur Uslu

    2017-01-01

    Full Text Available Intra- and subcorneal hematoma, a skin alteration seen palmar and plantar after trauma or physical exercise, can be challenging to distinguish from in situ or invasive acral lentiginous melanoma. Thus, careful examination including dermoscopic and histologic assessment may be necessary to make the correct diagnosis. We here present a case of a 67-year-old healthy female patient who presented with a pigmented plantar skin alteration. Differential diagnoses included benign skin lesions, for example, hematoma or melanocytic nevus, and also acral lentiginous melanoma or melanoma in situ. Since clinical and dermoscopic examinations did not rule out a malignant skin lesion, surgical excision was performed and confirmed an intracorneal hematoma. In summary, without adequate physical trigger, it may be clinically and dermoscopically challenging to make the correct diagnosis in pigmented palmar and plantar skin alterations. Thus, biopsy or surgical excision of the skin alteration may be necessary to rule out melanoma.

  13. Laptop computer-induced erythema ab igne in a child and review of the literature.

    Science.gov (United States)

    Arnold, Andreas W; Itin, Peter H

    2010-11-01

    We report here the case of a 12-year-old boy with erythema ab igne on his left thigh caused by the use of a laptop computer. This is the youngest of the 10 reported patients with this laptop-induced dermatosis since its first description in 2004. Erythema ab igne is a reticular, pigmented, sometimes telangiectatic dermatosis that is caused by prolonged exposure to a heat or infrared source. In laptop-induced erythema ab igne, the localization on the thighs and asymmetry are characteristic. The heat originates from the optical drive, the battery, or the ventilation fan of the computer.

  14. Estadísticas en el cáncer de piel Statistics in skin cancer

    Directory of Open Access Journals (Sweden)

    RE Achenbach

    Full Text Available Se establecen puntos de vista diferentes que influyen, al momento de presentar trabajos de estadística en la esfera del cáncer de la piel, especialmente respecto de las denominadas dermatosis precancerosas, al carcinoma espinocelular y cuál es la más frecuente en el ser humano.A different point of view in the sphere of statistics in skin cancer, specially about squamous cell carcinoma, solar keratosis and the so called precancerous dermatosis. The numerous papers about the issue from AB Ackerman, should be known in order of confident statistics numbers.

  15. Successful treatment of hand and foot psoriasis with efalizumab therapy.

    Science.gov (United States)

    Fretzin, Scott; Crowley, Jeffrey; Jones, Loretta; Young, Melodie; Sobell, Jeffrey

    2006-10-01

    Hand and foot psoriasis can appear in a plaque-type or pustular-type form. Any form of psoriasis that occurs on the hands and feet can have a debilitating effect on the patient's daily functions. Here we present a case series of patients with plaqueor pustular-type hand and foot psoriasis whose conditions were successfully managed with the biologic agent efalizumab. In many of these patients, the disease was refractory to multiple systemic psoriasis treatments. Treatment with efalizumab was effective and well-tolerated, with few adverse events. Many of the patients described here reported an improvement in both their physical functioning and health-related quality of life. The efficacy of efalizumab in treating these cases of hand and foot psoriasis suggests that it may provide therapeutic benefit.

  16. Therapy for psoriatic arthritis with infliximab

    OpenAIRE

    V. V. Badokin; Yu. L. Korsakova; V G Barskova; M S Eliseyev; F M Kudayeva

    2009-01-01

    Objective: to study the efficacy and tolerability of infliximab (Remicade) in the major syndromes of psoriatic arthritis (PA). Subjects and methods. The study was based on Remicade therapy in 22 patients with severe and moderate PA with polyarthritic, osteolytic and spondyloarthritic types of the joint syndrome, generalized psoriasis vulgar and erythrodermata, and pustular psoriasis. Inflammatory activity was determined by DAS 4 and the efficiency of therapy was evaluated by the ACR and EULAR...

  17. A Medical Research and Evaluation Facility Defense and Studies Supporting the Medical Chemical Defense Program. Task 95-38: Evaluation of the Vesicating Properties of Neutralized Chemical Agent Identification Set (CAIS) Components.

    Science.gov (United States)

    1997-06-01

    epidermal necrosis, follicular necrosis, dermal necrosis, vascular necrosis, hemorrhage, and pustular epidermitis) were graded by a veterinary pathologist...following decontamination, buprenorphine at a dose of approximately 0.1-0.25 mg/kg sc can be given every 8-12 hr following consultation with a staff...absence of microblisters by a qualified, experienced veterinary pathologist. a. Injections: Anesthetics only. b. Biosamples: No biological samples taken

  18. Evaluation of the Vesicating Properties of Neutralized Chemical Agent Identification Set (CAIS) Components

    Science.gov (United States)

    1997-06-01

    necrosis, hemorrhage, and pustular epidermitis) were graded by a veterinary pathologist. Eleven animals were dermally dosed with 1 gL neat HD and with 10...If signs of pain are exhibited following decontamination, buprenorphine at a dose of approximately 0.1-0.25 mg/kg sc can be given every 8-12 hr...and the slides are examined for histopathology and the presence or absence of microblisters by a qualified, experienced veterinary pathologist. a

  19. Parakeratosis pustulosa - a distinct but less familiar disease

    Directory of Open Access Journals (Sweden)

    Pandhi Deepika

    2003-01-01

    Full Text Available Parakeratosis pustulosa (PP is a distinct but less commonly known skin disease, which is frequently seen, in young girls. We describe the clinical and histological features of PP in a 7 month old female baby. Further, it is stressed that unless carefully looked for, this entity may be easily misdiagnosed as chronic paronychia, acrodermatitis of Hallopeau, pustular psoriasis, atopic dermatitis, tinea pedis or dry fissured eczematoid dermatitis and mistreated subsequently.

  20. Nocardia brasiliensis

    Science.gov (United States)

    Fernandes, Alison M; Sluzevich, Jason C; Mira-Avendano, Isabel

    2017-01-01

    Pulmonary nocardiosis is a severe and uncommon opportunistic infection caused by Nocardia species. We present a patient with cryptogenic organizing pneumonia who was receiving long-term immunosuppressive therapy, whose treatment course was complicated by cutaneous and pulmonary nocardiosis. Tissue cultures confirmed Nocardia brasiliensis . Nocardiosis should be a diagnostic consideration for patients treated with long-term immunosuppression who have worsening pulmonary symptoms and relapsing pustular skin lesions.

  1. Nocardia brasiliensis Infection Complicating Cryptogenic Organizing Pneumonia

    Directory of Open Access Journals (Sweden)

    Alison M. Fernandes

    2017-01-01

    Full Text Available Pulmonary nocardiosis is a severe and uncommon opportunistic infection caused by Nocardia species. We present a patient with cryptogenic organizing pneumonia who was receiving long-term immunosuppressive therapy, whose treatment course was complicated by cutaneous and pulmonary nocardiosis. Tissue cultures confirmed Nocardia brasiliensis. Nocardiosis should be a diagnostic consideration for patients treated with long-term immunosuppression who have worsening pulmonary symptoms and relapsing pustular skin lesions.

  2. Clinical case PAPA-syndrome (pyogenic arthritis, pyoderma gangrenosum, acne conglobata

    Directory of Open Access Journals (Sweden)

    Epifanova A.Y.

    2012-06-01

    Full Text Available

    The study presents a relatively rare case of dermatosis. It is PAPA syndrome in a 23 years-old female patient which is inherited as an autosomal dominant mode. The data about the etiology, pathogenesis, clinical picture were summarized, differential diagnosis was led. Problems with the treatment of the disease have been showed.

  3. Granuloma faciale of the scalp.

    Science.gov (United States)

    Leite, Inês; Moreira, Ana; Guedes, Rita; Furtado, Antónia; Ferreira, Eduarda Osório; Baptista, Armando

    2011-04-15

    Granuloma faciale (GF) is an uncommon dermatosis with characteristic clinicopathological features. Extrafacial isolated GF is extremely rare. Pulsed dye laser (PDL) is a treatment option for GF to minimize the risk of scarring. We report a case of a 78-year-old male with an extensive GF of the scalp successfully treated with pulsed dye laser (PDL).

  4. Granuloma Faciale

    Directory of Open Access Journals (Sweden)

    Sarkar Rashmi

    2002-01-01

    Full Text Available Granuloma faciale is an uncommon dermatosis of unknown aetiology, usually characterized by a solitary reddish-brown plaque or a nodule on the face. We report an unusual case of granuloma facial where the lesions were multiple and they responded to intralesional triamcinolone injections.

  5. Granuloma faciale: Case report and review.

    Science.gov (United States)

    Thiyanaratnam, Jayantha; Doherty, Sean D; Krishnan, Bhuvaneswari; Hsu, Sylvia

    2009-12-15

    Granuloma faciale (GF) is a rare benign chronic inflammatory dermatosis usually appearing only on the face. The lesions of GF typically present as single, asymptomatic, erythematous, non-changing nodules or plaques. We present an illustrative case of GF and briefly review available treatment options.

  6. Efficacy of anti-IL-1 treatment in Majeed syndrome

    DEFF Research Database (Denmark)

    Herlin, Troels; Fiirgaard, Bente; Bjerre, Mette

    2013-01-01

    Majeed syndrome is an autosomal recessive disorder characterised by the triad of chronic recurrent multifocal osteomyelitis, congenital dyserythropoietic anaemia and a neutrophilic dermatosis that is caused by mutations in LPIN2. Long-term outcome is poor. This is the first report detailing the t...

  7. Lichen planus hypertrophicus of the vulva - a rare entity.

    Science.gov (United States)

    Job, Anupa Mary; Kaimal, Sowmya

    2017-09-01

    Vulvovaginal lichen planus is a type of chronic inflammatory dermatosis of the vulva, usually seen as a part of widespread lichen planus. The common clinical types of vulval lichen planus include papulosquamous, erosive and pigmented types. Hypertrophic lichen planus of the vulva is a rare entity. We report a case of hypertrophic lichen planus of the vulva which clinically simulated genital warts.

  8. [Androgenetic alopecia in women as an aesthetic and psychological problem].

    Science.gov (United States)

    Kazimierczak, Małgorzata; Bielecka-Grzela, Stanisława; Klimowicz, Adam

    2008-01-01

    Androgenetic alopecia is a fairly common disorder which causes serious aesthetic and psychological problems. The paper discusses the etiology, diagnostics and possible treatment of androgenetic alopecia in women. Preparations for both general and external use in treatment of this dermatosis have been presented herein.

  9. Dematosis Papulosa Nigra | Shamad | Sudanese Journal of ...

    African Journals Online (AJOL)

    Subscription or Fee Access. Dematosis Papulosa Nigra. MMA Shamad. Abstract. Dermatosis papulosa nigra (DPN) is a benign and unique skin condition seen primarily in persons of dark colour. It is a pigmented papular eruption of the face and neck caused by a naevoid developmental defect of the pilosebaceous follicles.

  10. Balanitis Xerotica Obliterans: An experience with Buccal Mucosa ...

    African Journals Online (AJOL)

    Background: Balanitis Xerotic obliterans (BXO) or Penile Lichen Sclerosus is a dermatological condition affecting the genitalia and associated with chronic, progressive, sclerosing inflammatory dermatosis of unclear etiology. It was first described by Stuhmer in 1928, as being a rare condition but causes severe tissue ...

  11. SWEETS-SYNDROME IN MYELOID MALIGNANCY - A REPORT OF 2 CASES

    NARCIS (Netherlands)

    VANKAMP, H; VANDENBERG, E; TIMENS, W; HALIE, MR; DAENEN, SMGJ; Kraaijenbrink, R.

    TWO patients with a myeloid malignancy in whom Sweet's syndrome (acute febrile neutrophilic dermatosis) was diagnosed, are described. They suffered from fever and showed cutaneous lesions, with infiltration of the skin by mature neutrophils without signs of vasculitis. In one of them the clonal

  12. The pathogenesis of post kala-azar dermal leishmaniasis from the field to the molecule: does ultraviolet light (UVB) radiation play a role?

    DEFF Research Database (Denmark)

    Ismail, A; Khalil, E A G; Musa, A M

    2006-01-01

    Post kala-azar dermal leishmaniasis (PKDL) is a dermatosis caused by persistence of Leishmania donovani parasites in the skin following apparently successful treatment of visceral leishmaniasis. The distribution of PKDL lesions in Sudanese patients often mirrors the clothing habits of those...

  13. Guidelines of Care for the Management of Atopic Dermatitis Part 4: Prevention of Disease Flares and Use of Adjunctive Therapies and Approaches

    Science.gov (United States)

    Sidbury, Robert; Tom, Wynnis L.; Bergman, James N.; Cooper, Kevin D.; Silverman, Robert A.; Berger, Timothy G.; Chamlin, Sarah L.; Cohen, David E.; Cordoro, Kelly M.; Davis, Dawn M.; Feldman, Steven R.; Hanifin, Jon M.; Krol, Alfons; Margolis, David J.; Paller, Amy S.; Schwarzenberger, Kathryn; Simpson, Eric L.; Williams, Hywel C.; Elmets, Craig A.; Block, Julie; Harrod, Christopher G.; Begolka, Wendy Smith; Eichenfield, Lawrence F.

    2015-01-01

    Atopic dermatitis (AD) is a common, chronic inflammatory dermatosis that can affect all age groups. This evidence-based guideline addresses important clinical questions that arise in its management. In this final section, treatments for flare prevention and adjunctive and complementary therapies and approaches are reviewed. Suggestions on utilization are given based on available evidence. PMID:25264237

  14. Case report

    African Journals Online (AJOL)

    abp

    2015-06-24

    Jun 24, 2015 ... Abstract. Pyoderma gangrenosum (PG) and Sweet's Syndrome (SS) are inflammatory skin diseases caused by the accumulation of neutrophils in the skin and, rarely, in internal organs. These neutrophilic dermatosis (NDs) are distinguished by the existence of forms of transition or overlap. They are.

  15. Detection of R576 interleukin-4 receptor αn allele gene, serum interleukin-4, and eosinophilic cationic protein in atopic dermatitis patients

    Directory of Open Access Journals (Sweden)

    Abdel-Mawla M

    2009-01-01

    Full Text Available Atopic dermatitis (AD is a chronic pruritic skin disease. It results from a complex interplay between strong genetic and environmental factors. The aim of this work was to study some biochemical markers of the dermatosis. This included detection of R576 interleukin-4 receptor alpha allele gene. Twenty five patients with AD and 25 controls participated in this study.

  16. LICHEN STRIATUS – CASE REPORTS

    Directory of Open Access Journals (Sweden)

    Caius Solovan

    2013-07-01

    Full Text Available Lichen striatus is an acquired linear inflammatory dermatosis, not frequently reported, with a peculiar clinical aspect, most often described in adults, with a poor response to treatment. We described 4 cases of lichen striatus diagnosed over an 8-month period of time.

  17. Drug: D01550 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D01550 Drug Liranaftate (JAN/INN); Zefnart (TN) C18H20N2O2S 328.1245 328.4286 D0155...ing individual organs 26 Epidermides 265 Antiparasitic dermatosis agents 2659 Others D01550 Liranafta...qualene epoxidase inhibitor [KO:K00511] Thiocarbamates Liranaftate D01550 Liranaftate (JAN/INN) CAS: 88678-3

  18. IgA-mediated epidermolysis bullosa acquisita : Two cases and review of the literature

    NARCIS (Netherlands)

    Vodegel, RM; de Jong, MCJM; Pas, HH; Jonkman, MF

    2002-01-01

    We describe 2 adult patients with a subepidermal bullous dermatosis with exclusively linear IgA depositions along the epidermal basement membrane zone that were deposited in the sublamina densa zone as witnessed by direct immunoelectron microscopy. Indirect immunofluorescence microscopy of patients'

  19. Severe disseminated phaeohyphomycosis in an immunocompetent patient caused by Veronaea botryosa

    NARCIS (Netherlands)

    Bonifaz, A.; Davoudi, M.M.; de Hoog, G.S.; Padilla-Desgarennes, C.; Vázquez-González, D.; Navarrete, G.; Meis, J.F.; Badali, H.

    2013-01-01

    We present a severe case of disseminated phaeohyphomycosis due to Veronaea botryosa. A 32-year-old female, native from Cuautla, Morelos, Mexico, presented a chronic dermatosis which started 10 years earlier with multiple exophytic, multilobulated, soft, and pedunculated or sessile neoformations of

  20. Keratolysis exfoliativa (dyshidrosis lamellosa sicca): a distinct peeling entity

    NARCIS (Netherlands)

    Chang, Y.Y.; Velden, J. van der; Wier, G. van der; Kramer, D.; Diercks, G.F.; Geel, M. van; Coenraads, P.J.; Zeeuwen, P.L.J.M.; Jonkman, M.F.

    2012-01-01

    Background Keratolysis exfoliativa (KE), also known as dyshidrosis lamellosa sicca, is a palmoplantar dermatosis characterized by air-filled blisters and collarette desquamation. It has been regarded as a subtype of dyshidrotic eczema, a fungal infection or a dermatophytid reaction. KE may also

  1. ARSENIC SEPARATION FROM WATER USING ZEOLITES

    Science.gov (United States)

    Arsenic is known to be a hazardous contaminant in drinking water. The presence of arsenic in water supplies has been linked to arsenical dermatosis and skin cancer . Zeolites are well known for their ion exchange capacities. In the present work, the potential use of a variety of ...

  2. Drug: D00024 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00024 Drug Sulfur (JP16); Sulfur, precipitated (USP); Sulfur, sublimed (USP); Bens...Epidermides 265 Antiparasitic dermatosis agents 2659 Others D00024 Sulfur (JP16); Sulfur..., precipitated (USP); Sulfur, sublimed (USP) Anatomical Therapeutic Chemical (ATC) classification [BR...parations containing sulfur D10AB02 Sulfur D00024 Sulfur (JP16); Sulfur, precipitated (USP); Sulfur

  3. Pityriasis Rotunda: A Case Report of Familial Disease in an American-Born Black Patient

    Directory of Open Access Journals (Sweden)

    Emily G. Lefkowitz

    2016-03-01

    Full Text Available Pityriasis rotunda is an uncommon dermatosis with an unusual geographic and racial distribution. The skin disorder is characterized by sharply defined, perfectly circular, scaly patches with no inflammatory changes. Notably, it may be associated with underlying malignancy or chronic infection. We report an uncommon familial case in an American-born female.

  4. Incidence of the autoimmune dermatosis in dogs and cats and retrospective study of 40 cases of discoid lupus erythematosus attended at the Dermatology Service of the College of Veterinary Medicine and Animal Science of UNESP – Botucatu / Incidência das dermatopatias auto-imunes em cães e gatos e estudo retrospectivo de 40 casos de lupus eritematoso discóide atendidos no serviço de dermatologia da Faculdade de Medicina Veterinária e Zootecnia da UNESP – Botucatu

    Directory of Open Access Journals (Sweden)

    Jéssica Correa Rodrigues

    2010-09-01

    Full Text Available The objectives of this study were to do a survey of the autoimmune skin diseases and update the records regarding the occurrence of discoid lupus erythematosus in canine and feline populations attended at the Dermatology Service of the College of Veterinary Medicine and Animal Science of UNESP - Botucatu, including species, gender, breed, age, location and characteristic of the lesions. Results have shown that the order of occurrence, regarding the number of cases of autoimmune skin diseases in the animals attended by the Dermatology Service in the period from 1988 to 2007 was: discoid lupus erythematosus, pemphigus folliaceus, uveo-dermatologic syndrome, pemphigus vulgaris, systemic lupus erythematosus, necrolytic migratory erythema, multiforme erythema and plasmacytic pododermatitis. All the animals with discoid lupus erythematosus were dogs and most of them were mongrel females. More frequently breeds affected by discoid lupus erythematosus were german shepherd and akita and the mean age was 56 months. Most lesions were located in nasal planum, narines and periocular area and were characterized by crusting, depigmentation and erythema.Os objetivos do presente trabalho teve como objetivo fazer um levantamento da casuística de doenças dermatológicas auto-imunes e atualizar os dados referentes à ocorrência de lupus eritematoso discóide na população canina e felina atendida pelo Serviço de Dermatologia Veterinária da FMVZ-UNESP, campus de Botucatu, incluindo a espécie, sexo, raça, idade, localização e caracterização das lesões. Com a análise dos resultados, concluiu-se que a ordem de ocorrência de acordo com o número de casos de doenças dermatológicas auto-imunes nos animais atendidos pelo setor de dermatologia no período de 1988 a 2007 é: lupus eritematoso discóide, pênfigo foliáceo, síndrome úveo-dermatológica, pênfigo vulgar, lupus eritematoso sistêmico, eritema necrolítico migratório, eritema multiforme e pododermatite plasmocitária. Dos animais com lupus eritematoso discóide, todos eram da espécie canina, sendo a maioria fêmea e sem definição racial. As raças mais acometidas por lupus eritematoso discóide foram: Pastor Alemão e Akita e a média das idades foi de 56 meses. Notou-se que a maioria das lesões era localizada em plano nasal, narinas e região periocular. As lesões mais comumente observadas foram: crosta, despigmentação e eritema.

  5. Dermatological consequences of the Cs-137 radiological accident in Goiania, Goias State, Brazil; Repercussoes dermatologicas no acidente radioativo com o Cesio 137 em Goiania

    Energy Technology Data Exchange (ETDEWEB)

    Castro, Lia Candida Miranda de

    1996-07-01

    The objective of the present study was to analyse the occurrence of dermatosis in individuals that had been exposed to cesium{sup 137} during the radioactive accident in Goiania, in 1987 and detect pre-cancerous dermatosis or those predictive of low immunity. The groups were evaluated according to the intensity of radiation they had been exposed to and then compared to a control group of people not exposed to radiation. The population exposed to the cesium{sup 137} was comprised of 109 people, who were divided into Groups I and II, according to the CNEN norms. In group I, 54 people with {<=} 20 rads exposure and/or radio lesion were included; in group II, 55 people with > 20 rads exposure were included, along with the children of group I individuals. This was a historic cohort study, that is, a retrospective study that lasted 9 years, extending from September of 1987 to August, 1996. The presence of the oncoprotein p-53 was studied in the radio lesions of 10 patients. There is no evidence of an increase in the incidence of dermatosis in the exposed groups, excepts for pyoderma in patients with radio lesions. The most frequent dermatosis were: pyoderma, pityriasis versicolor, scabies, dermatophytosis and seborrhoeic dermatitis. The results obtained were not statistically significant for the evaluation of dermatosis predictive of low immunity or precancerous lesions. The oncoprotein p-53 in individuals with radio lesion showed a 80% positivity rate and risk factor estimated in 8 times, for the test. It has proved to be useful because it represents one more option in terms of propaedeutic evaluation and suggests that one should pay close and continuous attention in order to better control the evolution of these individuals. (author)

  6. Assessment of the efficacy of cryosurgery in the treatment of granuloma faciale.

    Science.gov (United States)

    Panagiotopoulos, A; Anyfantakis, V; Rallis, E; Chasapi, V; Stavropoulos, P; Boubouka, C; Katsambas, A

    2006-02-01

    Granuloma faciale (GF) is an uncommon dermatosis of unknown pathogenesis. Multiple treatments have been proposed with varying results. We report nine cases treated successfully with cryosurgery and we review the literature. To study the efficacy, tolerability and safety of cryosurgery techniques in the treatment of GF. Nine immunocompetent adults with GF were treated by cryosurgery. The initiation of the therapy was preceded by a 60-day washout period in all subjects using other medication. Two different techniques were used (open-spray and contact cryo-probe). All patients were treated successfully. Apart from mild postinflammatory hypopigmentation in two patients that resolved within 4 months, no other adverse event was mentioned. During an average 24-month follow-up period after the integration of therapy, no recurrences were observed. Cryosurgery is an efficient, safe, inexpensive, easily used method for this uncommon dermatosis, which can be proposed as a treatment of first intention.

  7. The study of microbial-intestinal tissue complex in patients with atopic dermatitis in different periods of clinical course of the disease

    Directory of Open Access Journals (Sweden)

    A. V. Babkin

    2011-01-01

    Full Text Available It was examined 40 patients with atopic dermatitis in various stages of the clinical course of dermatosis. It has revealed typical endoscopic changes of the gastrointestinal tract in patients with atopic dermatitis in quiescent and acute stages. It has studied the cellular composition of infiltrates and histomorphology of mucous coat of stomach and distal part of sigmoid colon. It has found the generic dysbiotic malfunctions of intestinal microflora in different periods of the clinical course of dermatosis. It is suggested an assumption about the relations between morphological changes of mucous coat of stomach and distal part of sigmoid colon in patients with atopic dermatitis with symtomatic dysbiotic disorders of the intestine and the severity of skin lesions in atopic dermatitis.

  8. THE FREQUENT SKIN DISEASES DIAGNOSED AT UNIVERSITY STUDENTS

    Directory of Open Access Journals (Sweden)

    Yesim KAYMAK

    2005-12-01

    Full Text Available The incidence of some skin diseases are increasing at adolescent and early adulthood period. The most frequent disease at this period is acne vulgaris whereas fungal diseases, dermatitis, dermatosis which are due to stress and other reasons, oral mucosal lesions and herpetic lesions of perioral region are also frequent. In this research we aim to determine the frequent dermatologic diseases of university students and 147 female, 74 male, a total of 221 students are included. We questioned the dermatologic complaints of students, then examined dermatologically in detail and registered ages, sexes, findings of the dermatological examination and dermatological diagnostic informations. As a result it is found out that the most frequent diseases are acne vulgaris (34.1%, allergic and pruritic dermatosis (16.6%, fungal diseases ( 13.0%, and eritamatous-squamous disease (8.3%. [TAF Prev Med Bull 2005; 4(6.000: 313-320

  9. A Case of Confluent and Reticulated Papillomatosis Treated with a Combination of Topical Calcipotriol and Tretinoin

    Directory of Open Access Journals (Sweden)

    Ayşegül Turan

    2013-12-01

    Full Text Available Confluent and reticulated papillomatosis (CRP is a dermatosis first described by Gougerot and Carteaud. It is proposed to occur as a result of abnormal host response to Pityrosporum ovale or to be a keratinization disorder. Clinically, brownish hyperkeratotic, reticular papules and plaques which tend to coalesce are seen on seborrheic areas. A 16-year-old female patient admitted to our outpatient clinic because of itchy brown spots on her neck, anterior trunk and the back region for three years. She was diagnosed as CRP due to the clinical and histopathological findings and was treated successfully with a combination of topical calcipotriol and tretinoin. We aimed to review the clinical findings and treatment options of CRP, a rare dermatosis, in the light of the literature on the occasion of this case.

  10. Lichen striatus associated with psoriasis vulgaris treated with oral acitretin

    Directory of Open Access Journals (Sweden)

    Enzo Errichetti

    2014-01-01

    Full Text Available Lichen striatus (LS is an uncommon dermatosis of unknown etiology that presents as a continuous or interrupted linear band of pink, tan, red or skin-colored papules in a blaschkoid distribution. The lesions are generally solitary and unilateral, but unusual extensive cases with multiple and bilateral lesions have been also described. Albeit LS is typically an asymptomatic and self-limited dermatosis, it may cause a significant psychological distress in some patients, thus requiring an appropriate therapy. Topical steroid is the most commonly used treatment but it is not always effective. We report a case of LS unresponsive to topical steroid therapy associated with psoriasis vulgaris successfully treated with oral acitretin.

  11. Schnitzler syndrome: clinical features and histopathology

    Directory of Open Access Journals (Sweden)

    Dingli D

    2015-06-01

    Full Text Available David Dingli,1,2 Michael J Camilleri3 1Division of Hematology, Department of Internal Medicine, 2Department of Molecular Medicine, 3Department of Dermatology, Mayo Clinic, Rochester, MN, USA Abstract: Schnitzler syndrome is a rare and underrecognized syndrome characterized by chronic urticaria, a monoclonal protein, and a variety of other symptoms, including fever, bone pain, organomegaly, and evidence of an acute phase response. Biopsy of an involved area of the skin shows a neutrophilic infiltrate without evidence of vasculitis or hemorrhage. Although the etiology of the syndrome is unknown, current evidence suggests this is an autoinflammatory syndrome. Recognition of this syndrome is critical since it is highly responsive to anakinra. Keywords: neutrophilic urticarial dermatosis, autoinflammatory syndrome, monoclonal gammopathy, neutrophilic dermatosis, anakinra 

  12. History of Morgellons disease: the same name for different psychodermatologic diseases?

    Science.gov (United States)

    Ferreira, Bárbara Roque; Roccia, Maria Grazia; Cardoso, José Carlos; França, Katlein; Wollina, Uwe; Lotti, Torello; Fioranelli, Massimo

    2017-10-01

    "Morgellons disease" has been a controversial topic in the history of psychodermatology. The most consensual scientific opinion is that it is a primary psychiatric disorder, particularly, a delusional disorder, although others were also pointed out. Some authors have suggested that it may correspond to a common dermatosis with secondary psychopathology. The Morgellons Research Foundation has advocated that it is "an emerging infectious" entity. This paper intends to critically review the main ideas and controversies, since its first description.

  13. Necrobiosis lipoidica

    Directory of Open Access Journals (Sweden)

    Maricel Sucar Batista

    2015-11-01

    Full Text Available This is a case of a female patient with necrobiosis lipoidica, an entity that belongs to the group of uncommon ulcerative cutaneous dermatosis of unknown cause, closely related to diabetes mellitus, with characteristic clinical manifestations and very difficult to be treated. Considering the results of physical examination and investigations, including biopsy, she was diagnosed with non-diabetic necrobiosis lipoidica. She was treated with pentoxifylline and ozone therapy, so her condition is improving.

  14. Allopurinol in the treatment of acquired reactive perforating collagenosis*

    OpenAIRE

    Tilz, Hemma; Becker, Jürgen Christian; Legat, Franz; Schettini, Antonio Pedro Mendes; Inzinger, Martin; Massone, Cesare

    2013-01-01

    Acquired reactive perforating collagenosis is a perforating dermatosis usually associated with different systemic diseases, mainly diabetes mellitus and/or chronic renal insufficiency. Different therapies have been tried but treatment is not standardized yet and remains a challenge. In the last few years, allopurinol has been reported as a good therapeutic option for acquired reactive perforating collagenosis. We describe the case of a 73-year-old man affected by acquired reactive perforating...

  15. A Concomitant Case of Orbital Granuloma Faciale and Eosinophilic Angiocentric Fibrosis.

    Science.gov (United States)

    Chen, Valerie H; Grossniklaus, Hans E; DelGaudio, John M; Kim, Hee Joon

    Granuloma faciale is an eosinophilic dermatosis that typically presents as red-brown facial plaques of middle-aged white men, while eosinophilic angiocentric fibrosis is a histologically similar fibrotic condition affecting the respiratory mucosa. Both are very uncommon conditions and pose a therapeutic challenge. While a handful of reports have reported concurrent presentation, the authors present the first case of eyelid granuloma faciale with eosinophlilic angiocentric fibrosis.

  16. Digit loss due to Demodex spp. infestation in a dog: clinical and pathological features

    Science.gov (United States)

    Grandi, F.; Pasternak, A.; Beserra, H.E.O.

    2013-01-01

    Here we describe a rare clinical manifestation of canine pododemodicosis. A dog was presented with pedal erythema, scaling, crusting, severe edema and digit loss. The following diseases were taken into account for the differential diagnosis: pododemodicosis, lethal acrodermatitis, zinc responsive dermatosis and pemphigus foliaceus. Results from skin biopsies revealed the presence of Demodex spp. of mites in the follicular infundibula and a severe inflammatory process (pododemodicosis). Upon the acaricidal treatment, the patient exhibited favorable signs of clinical improvement. PMID:26623312

  17. Dermoscopic findings in different clinical variants of lichen planus. Is dermoscopy useful?

    Science.gov (United States)

    Friedman, Paula; Sabban, Emilia Cohen; Marcucci, Carolina; Peralta, Rosario; Cabo, Horacio

    2015-01-01

    Lichen planus (LP) is a papulosquamous dermatosis that involves the skin, scalp, nails and mucous membranes. Although its pathogenesis is still unknown, there is evidence that an imbalance of immunologic cellular reactivity plays an important role. Histopathologic examination reveals characteristic interface dermatitis. Dermoscopy is a non-invasive tool, useful in the assessment of inflammatory dermatoses, such as lichen planus. In this paper we describe the dermoscopic findings of different variants of LP (ungual, cutaneous, planopilaris, pigmentosus). PMID:26693092

  18. Palmoplantar Lichen Planus: Dört olgu sunumu

    OpenAIRE

    Uçmak, Derya; Azizoğlu, Ruken; Harman, Mehmet

    2015-01-01

    Lichen planus is a benign, inflammatory and itchy dermatosis that is incurred by skin, skin extensions and mucosa. Lichen planus rarely show palmoplantar involvement. Since stratum corneum in palmoplantar lichen planus is extremely thick, lesions can be yellow colored instead of the purple colored papules that are classic lesions. Clinically, it might be confused with psoriasis, secondary syphilis, verruca vulgaris, hyperkeratotic eczema, palmoplantar keratodermas, hyperkeratotic type tinea p...

  19. Estudio del Manto Lípido de la Piel y sus Modificaciones en algunas Enfermedades Cutáneas y Bajo la Acción de Jabones y Detergentes.

    OpenAIRE

    Sotillo Gago, Ismael

    2016-01-01

    En este trabajo, nos proponemos hacer un estudio del manto lípido de la superficie cutánea y sus posibles variaciones en determinadas dermatosis en comparación con el manto lípido de la piel normal. Las enfermedades a estudiar son: a) PSORIASIS b) SEBORREA PURA c) ACNE JUVENIL d) PIEL SOMETIDA A LAVADOS CON JABONES Y DETERGENTES desconociendo la etiopatogenia de todos estos procesos, determinados trabajos realizados por algunos autores como WILKINSON, STRAU...

  20. Atypical Histiocyte-Rich Sweet’s Syndrome

    Directory of Open Access Journals (Sweden)

    Sharon Chi

    2017-01-01

    Full Text Available Sweet’s Syndrome is a rare neutrophilic dermatosis thought to be a result of immune dysregulation occurring in the setting of drug exposure, recent infection, pregnancy, and underlying malignancy or idiopathic with specific and widely accepted diagnostic criteria established in the literature. Other organ systems can be involved with varying degrees of severity. An unusual case of Sweet’s Syndrome associated with myopericarditis, acral involvement, and atypical histological findings with predominance of histiocytes is described here.

  1. Uji Efektivitas Sabun Transparananti Jerawat Minyak Atsiri Kulit Buah Jeruk Pontianak (Citrus Nobilis Lour. Var. Microcarpa) Terhadap Isolat (Propionibacterium Acnes)

    OpenAIRE

    Mariani Prapanta

    2014-01-01

    Acne vulgaris is one of dermatosis problem's that appear most at teenagerand caused by Propionibacterium acnes bacteria that had important role at acnes'phatogenesis. The purpose of this research was to know the effectiveness ofantibacterial activity from essential oil of pontianak orange peel that is formulatedas a transparent soap. The transparent soaps were formulated using the isolate ofPropionibacterium acnes and disc diffusion method (Kirby-Bauer test). Theisolate of Propionibacterium...

  2. Acne inversa goes an extra mile than hidradenitis suppurativa

    OpenAIRE

    Witmanowski, Henryk; Szychta, Pawe?; St?pniewski, S?awomir; Mackiewicz-Wysocka, Ma?gorzata; Czy?ewska-Majchrzak, ?ucja; Wasilewska, Agnieszka

    2013-01-01

    Acne inversa (AI, hidradenitis suppurativa, Velpeau?s disease, Verneuil?s disease) is a severe, chronic inflammatory dermatosis of unknown etiology, detected on the basis of clinical symptoms more frequently in women than in men. Purulent lesions in the form of nodules and inflammatory tumors, fistulas and scars are present in the areas with hair follicles and apocrine glands, most commonly on the armpits, groin, around the anus and pubic region. Acne inversa can lead to physical and mental d...

  3. Pyoderma gangrenosum Preceding the diagnosis of systemic lupus erythematosus.

    Science.gov (United States)

    Waldman, Mark A; Callen, Jeffrey P

    2005-01-01

    Patients with systemic lupus erythematosus (SLE) often develop leg ulceration, particularly those with antiphospholipid antibodies or with vasculitis. Pyoderma gangrenosum (PG) is an idiopathic ulcerative neutrophilic dermatosis that is commonly associated with inflammatory bowel disease or seronegative polyarthritis. Although PG-like lesions have been commonly described in patients with the antiphospholipid antibody syndrome, the occurrence of PG as a preceding manifestation of SLE has only rarely been reported. We present a patient who developed PG roughly 8 years prior to developing SLE.

  4. Metastatic Calcinosis Cutis: A Case in a Child with Acute Pre-B Cell Lymphoblastic Leukemia

    OpenAIRE

    Juan Pablo Castanedo-Cázares; Amalia Reyes-Herrera; Diana Hernández-Blanco; Cuauhtémoc Oros-Ovalle; Bertha Torres-Álvarez

    2015-01-01

    Hypercalcemia in children with malignancy is an uncommon condition. It has been described in leukemia patients with impaired renal excretion of calcium or osteolytic lesions. Metastatic calcinosis cutis (MCC) may develop if hypercalcemia persists. We report the case of a 5-year-old girl with an atypical dermatosis and unspecific gastrointestinal symptoms. Considered clinical diagnoses were xanthomas, histiocytosis, molluscum contagiosum, and nongenital warts. Cutaneous histological analysis s...

  5. Digit loss due to Demodex spp. infestation in a dog: clinical and pathological features

    Directory of Open Access Journals (Sweden)

    F. Grandi

    2013-05-01

    Full Text Available Here we describe a rare clinical manifestation of canine pododemodicosis. A dog was presented with pedal erythema, scaling, crusting, severe edema and digit loss. The following diseases were taken into account for the differential diagnosis: pododemodicosis, lethal acrodermatitis, zinc responsive dermatosis and pemphigus foliaceus. Results from skin biopsies revealed the presence of Demodex spp. of mites in the follicular infundibula and a severe inflammatory process (pododemodicosis. Upon the acaricidal treatment, the patient exhibited favorable signs of clinical improvement.

  6. Use of dermoscopy in the diagnosis of temporal triangular alopecia.

    Science.gov (United States)

    Campos, Jullyene Gomes de; Oliveira, Cláudia Marina Puga Barbosa; Romero, Sandra Adolfina Reyes; Klein, Ana Paula; Akel, Patricia Bandeira de Melo; Pinto, Giselle Martins

    2015-01-01

    Temporal triangular alopecia, also referred as congenital triangular alopecia, is an uncommon dermatosis of unknown etiology. It is characterized by a non-scarring, circumscribed alopecia often located unilaterally in the frontotemporal region. It usually emerges at ages 2-9 years. Alopecia areata is the main differential diagnosis, especially in atypical cases. Dermoscopy is a noninvasive procedure that helps distinguish temporal triangular alopecia from aloepecia areata. Such procedure prevents invasive diagnostic methods as well as ineffective treatments.

  7. Laptop induced erythema ab igne.

    Science.gov (United States)

    Nayak, Sudhir U K; Shenoi, Shrutakirthi D; Prabhu, Smitha

    2012-03-01

    Erythema ab igne is a reticular, pigmented dermatosis caused by prolonged and repeated exposure to infrared radiation that is insufficient to produce a burn. The use of laptop computers has increased manifold in the recent past. Prolonged contact of the laptop with the skin can lead to the development of erythema ab igne. We present a case of erythema ab igne secondary to laptop use in an Indian student.

  8. Clinical Evaluation of a New-Formula Shampoo for Scalp Seborrheic Dermatitis Containing Extract of Rosa centifolia Petals and Epigallocatechin Gallate: A Randomized, Double-Blind, Controlled Study

    OpenAIRE

    Kim, Yu Ri; Kim, Jeong-Hwan; Shin, Hong-Ju; Choe, Yong Beom; Ahn, Kyu Joong; Lee, Yang Won

    2014-01-01

    Background Scalp seborrheic dermatitis is a chronic type of inflammatory dermatosis that is associated with sebum secretion and proliferation of Malassezia species. Ketoconazole or zinc-pyrithione shampoos are common treatments for scalp seborrheic dermatitis. However, shampoos comprising different compounds are required to provide patients with a wider range of treatment options. Objective This study was designed to evaluate a new-formula shampoo that contains natural ingredients-including e...

  9. EVALUATION OF HEALTH IN CHILDREN LIVING IN REGION WITH DEVELOPED CEMENT INDUSTRY

    Directory of Open Access Journals (Sweden)

    M.V. Kudin

    2010-01-01

    Full Text Available Evaluation of health state in children living in the city with developed cement industry showed presence of pre-nosological forms of ecologically conditioned diseases coming into being as a result of exposure with salts of heavy metals in cement dust. Key words: children, cement dust, bronchial asthma, pneumoconiosis, dermatosis, crystaluria, nephropathy, gestosis.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2010;9(5:42-47

  10. Contenido

    Directory of Open Access Journals (Sweden)

    Facultad de Medicina Revista

    1938-01-01

    Full Text Available I DERMATOSIS PIGMENTADA Y PÚRPURICA. Profesor Gonzalo Reyes García. Bogotá. II CONSIDERACIONES ACERCA DE LA OPINIÓN DEL PROFESOR BEN KARPMAN SOBRE PSICODIAGNOSTICO y PSICOTERAPIA DEL CRIMINAL. Alumno Luis Jaime Sánchez. Bogotá. III HOMENAJE AL PROFESOR LUIS ZEA URIBE. Profesor Roberto Franco y doctor Alfonso Castro. Bogotá. IV SECCIÓN OFICIAL V NOTICIAS MÉDICAS VI BOLETÍN BIBLIOGRÁFICO

  11. APPLICATION OF LOCAL ANAESTHETIC CREAM AMONG CHILDREN, WHILE REMOVING ELEMENTS OF CONTAGIOSUM EPITHELIALE

    Directory of Open Access Journals (Sweden)

    E.I. Pil'gui

    2007-01-01

    Full Text Available Contagiosum epitheliale is a wide spread dermatosis among younger and preteen children. The removal of elements is accompanied with the sensations of pain and conducive to the development of the adverse psychological and physiological responses of the child's body. In the present research the authors evaluated the efficacy of the local anaesthetic while removing elements of contagiosum epitheliale. The article presents etiology, clinical peculiarities, new methods of diagnostics and disease treatment.Key words: contagiosum epitheliale, anesthesia, pain evaluation, children.

  12. Lupus miliaris disseminatus faciei: report of a new case and brief literature review.

    Science.gov (United States)

    Rocas, Delphine; Kanitakis, Jean

    2013-03-15

    Lupus miliaris disseminatus faciei (LMDF) is a rare dermatosis with characteristic clinicopathological features but of unknown etiolgy. We report a new typical case of LMDF. A 29-year-old man presented with an asymptomatic, micropapular midfacial eruption. Histological examination revealed a dermal granulomatous reaction with central areas of necrosis and occasionally degenerated hair follicles. Workup for sarcoidosis was negative. A moderate improvement was achieved with systemic treatment with doxycycline. A brief overview of the main features of LMDF is presented.

  13. Skin changes in chronic kidney disease

    Directory of Open Access Journals (Sweden)

    Joanna M. Przepiórka-Kosińska

    2017-04-01

    Full Text Available Chronic kidney disease causes skin changes which may sometimes be the first sign of kidney failure. Specific skin changes include acquired perforating dermatosis, porphyria cutanea tarda, pseudoporphyria, calcinosis and nephrogenic systemic fibrosis. The majority of patients present with cutaneous manifestations which are classified as non-specific, including xerosis, pruritus, pigmentation disturbances, nail plate abnormalities, uraemic frost and gynaecomastia. Treatment improving kidney function (dialysis therapy or kidney transplantation also leads to the resolution of skin lesions.

  14. Ichthyosiform large plaque parapsoriasis: Report of a rare entity

    Directory of Open Access Journals (Sweden)

    Falguni Nag

    2013-01-01

    Full Text Available Large plaque parapsoriasis (LPP is an idiopathic, chronic scaly dermatosis classified within parapsoriasis group of diseases, occurring commonly in middle aged patients of all races and geographic regions. LPP and its variants are closely related to the patch stage of mycosis fungoides. The two types of LPP mostly described are the poikilodermatous and retiform parapsoriasis. We are reporting an ichthyosiform LPP for its rarity.

  15. Diagnostic sampling and gross pathology of New World camelids.

    Science.gov (United States)

    Bildfell, Robert J; Löhr, Christiane V; Tornquist, Susan J

    2012-11-01

    This article provides an overview of tests and appropriate samples to send to a Veterinary Diagnostic Laboratory for the diagnosis of common diseases of New World Camelids (NWC) such as abortions, congenital anomalies, anemia, enteritis, endoparasitism, gastric ulcer, hepatic lipidosis, encephalitis, pneumonia, dermatosis, neoplasia and cryptococcosis. Unique anatomic features of NWC and common findings encountered during gross necropsy examination are briefly reviewed. Copyright © 2012 Elsevier Inc. All rights reserved.

  16. Semblanza del doctor Roberto Núñez Andrade (1905-1979: el primer dermatólogo del Hospital Infantil de México

    Directory of Open Access Journals (Sweden)

    Ofelia Azucena Vega-Morquecho

    2016-09-01

    Full Text Available Roberto Núñez Andrade (1905-1979, fue un destacado dermatólogo mexicano interesado en las enfermedades de la piel de los niños, quien por sus aportaciones científicas y por haber enfocado una parte de su práctica clínica a las dermatosis infantiles, debe ser considerado un precursor de la dermatología pediátrica en México.

  17. Identificación y actividad farmacológica de principios de especies antiinflamatorias.

    OpenAIRE

    Yueqin, Zeng

    2006-01-01

    RESUMEN La presente Tesis Doctoral se ha centrado en el estudio de especies utilizadas en medicina tradicional china y otras especies utilizadas en medicina popular como antiinflamatorias, particularmente en procesos que afecten a la piel como dermatitis y dermatosis. Las plantas medicinales objeto de estudio han sido Schinus molle, Lysimachia foenum-graecum, Lithospermum erythrorhizon, Forsythia suspensa e Isodon xerophilus. El desarrollo experimental ha consistido en la obtención prev...

  18. Clinical case of a Goldenhar syndrome diagnostics in a newborn boy

    Directory of Open Access Journals (Sweden)

    Slesarenko N.A.

    2016-09-01

    Full Text Available Relative importance of the current issue is based on rare occurrence of this dermatosis, its genetic predisposition and occurrence in early childhood. The Goldenhar syndrome diagnosing is a difficult task and causes difficulty in selecting treatment, due to large number of clinical syndromes presenting with facial deformities and the inability to quickly identify concomitant signs of damage to other organs and systems.

  19. Pyoderma gangrenosum in a renal transplant recipient: A case report and review of literature

    Directory of Open Access Journals (Sweden)

    P K Jha

    2015-01-01

    Full Text Available Pyoderma gangrenosum (PG is a rare disorder of unknown etiology characterized by multiple cutaneous ulcers with mucopurulent or hemorrhagic exudate. This sterile neutrophilic dermatosis is known to occur in association with malignancy, infection, autoimmune disorders and drugs. Occurrence of PG in a renal transplant recipient, who is already on immunosuppressants, is rare. We hereby report a renal transplant recipient who developed PG 1-month after transplant and responded well to treatment with escalated dose of oral steroid.

  20. Old condition caused by modern technology - erythema ag igne

    OpenAIRE

    Sara Ferreira; Lourdes Mota; Óscar Tellechea; Nuno Figueiredo; Rosa Mascarenhas

    2016-01-01

    Introduction:Erythema ab igne is a rare reticular pigmented dermatosis, caused by prolonged and repeated exposure to heat. Multiple heat sources have been reported to cause this condition, as fire or stove in proximity with the skin. Case report:We report a case of a diabetic teenager with erythema ab igne induced by a laptop computer. Conclusions: Laptop induced erythema ab igne is an underdiagnosed clinical entity. In the future maybe it will be more frequent due to the improper use...

  1. Developmental Neurotoxic Effects of Percutaneous Drug Delivery: Behavior and Neurochemical Studies in C57BL/6 Mice

    OpenAIRE

    Huali Wu; Junyi Feng; Wenting Lv; Qiaoling Huang; Mengsi Fu; Minxuan Cai; Qiangqiang He; Jing Shang

    2016-01-01

    Dermatosis often as a chronic disease requires effective long-term treatment; a comprehensive evaluation of mental health of dermatology drug does not receive enough attention. An interaction between dermatology and psychiatry has been increasingly described. Substantial evidence has accumulated that psychological stress can be associated with pigmentation, endocrine and immune systems in skin to create the optimal responses against pathogens and other physicochemical stressors to maintain or...

  2. A Guide to the Ingredients and Potential Benefits of Over-the-Counter Cleansers and Moisturizers for Rosacea Patients

    Science.gov (United States)

    Miller, Richard

    2011-01-01

    It is difficult for rosacea patients to discern which products and ingredients will be beneficial to their skin and which products will lead to an exacerbation of the signs and symptoms of rosacea. In this paper, the authors provide a brief overview of rosacea, its pathogenesis, signs and symptoms, and the management of the two major rosacea subtypes—erythematotelangiectatic rosacea and papular pustular rosacea. Reviewed in greater detail are the common ingredients used in over-the-counter cleansers and moisturizers with discussion of how these ingredients potentially benefit or harm the skin of patients with rosacea. Clinical studies investigating the benefits of using certain over-the-counter cleansers and moisturizers in patients with erythematotelangiectatic rosacea and papular pustular rosacea with or without topical prescription therapy are also reviewed. The specific formulas used in the clinical studies include a sensitive skin synthetic detergent bar, a nonalkaline cleanser and moisturizer, polyhydroxy acid containing cleanser and moisturizer, and a ceramide-based cleanser and moisturizer formulated in a multivesicular emulsion. Based on review of available data, the authors conclude that the use of mild over-the-counter cleansers and moisturizers is beneficial for patients with erythematotelangiectatic rosacea and papular pustular rosacea. The properties of over-the-counter cleansers and moisturizers that contribute to their mildness include an acidic-neutral pH to minimize the flux in skin pH; surfactants or emulsifiers that will not strip the skin of its moisture or strip the lipids and proteins of the stratum corneum; moisturizing ingredients such as emollients, humectants, and occlusives; and formulas without potential irritants and allergens. The most consistent clinical benefits demonstrated in the reviewed studies were a subjectively perceived improvement in subjective symptoms of dryness and irritation as well as an objective improvement in

  3. Bacterial resistance to antibiotics in acne vulgaris: An in vitro study

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    Hassanzadeh Parvin

    2008-01-01

    Full Text Available Background: Acne vulgaris is one of the most common skin disorders in youth especially during the puberty. Objective: This in vitro study was performed to determine the antibiotic resistance and sensitivity in acne vulgaris. Materials and Methods: Samples were collected from normal skin and nodulocystic and pustular skin lesions of one hundred youngsters (64 girls, 36 boys among college students in the age range of 18-24 years old. The specimens were cultured individually on blood agar and Muller-Hinton media. The cultures were then incubated under both aerobic and anaerobic conditions for 2 to 7 days. Bacteria were identified and their resistance to common antibiotics was evaluated according to the standard procedures. Results: In aerobic culture of pustular and nodulocystic skin lesions, Staphylococcus aureus was present in 41% of subjects, Staphylococcus epidermidis in 53% and Micrococcus spp in 45% of subjucts. In anaerobic bacterial culture of pustular and nodulocystic skin lesions, Staphylococcus aureus was present in 39%, Propionibacterium acne in 33% and Staphylococcus epidermidis in 21% of subjects. The results of present study revealed that clindamycin and erythromycin were the least effective antibiotics for Propionibacterium acne while tetracycline was the least effective for Staphylococcus aureus in vitro . A synergic effect of benzoyl peroxide, erythromycin or clindamycin was noticed. Rifampin was the most effective antibiotic in vitro . Conclusion: Our results showed that rifampin was the most sensitive antibiotic in vitro for acne vulgaris. To achieve a better treatment, a combination of rifampin with other antibiotics may be more efficient. We suggest in vivo studies for better evaluation and treatment of acne patients with rifampin.

  4. Occupational hand dermatoses of hairdressers in Tainan City.

    Science.gov (United States)

    Guo, Y L; Wang, B J; Lee, J Y; Chou, S Y

    1994-01-01

    OBJECTIVES--To determine the prevalence, clinical features, and patterns of hand dermatosis in hairdressers in Tainan, Taiwan, and to examine the associations between patterns of dermatosis and risk factors such as job description, work exposure, and sensitisation to common allergens. METHODS--Interviews, examinations, and patch tests of the hairdressers from nine hairdressing stores randomly selected from Tainan City. Patch test agents included 41 substances with common allergens, shampoo preservatives, hair dyes, permanent waving and bleaching agents. RESULTS--98 hairdressers finished the examination, 83% of them had occupational dermatosis and 32% had scissor induced scars or wounds. Most of the dermatoses belonged to either dry metacarpophalangeal dermatitis or eczema of the fingers. 44% of the hairdressers showed positive skin reaction to one or more patch test agents. The patch test results were different from previous reports in that the most common allergens were nickel, thimerosal, Captan, Kathon CG, and fragrance mix, and that the sensitivity to hair dye and permanent wave ingredients were low. The dry metacarpophalangeal dermatitis was associated with exposure to shampoo, and the eczema of the fingers with skin sensitivity to patch test agents. CONCLUSION--Hairdressers in Tainan City had a high prevalence of dermatoses including traumatic wounds, and allergic and irritant contact dermatitis. The rates of sensitivity to some of the common sensitising agents were different from previous reports. Images Figure 1 Figure 2 PMID:8000494

  5. Multifocal Langerhans Cell Granulomatosis (Hand-schuller - Christian Disease

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    MPS Sawhney

    1989-01-01

    Full Text Available A 47 year old female developed multifocal Langerhans cell granulomatosis (Hand-Schuller-Christian disease manifesting as papulo-pustular, nodular, crusted and scaly lesions, xanthelasma, ulceration of gingival mucosa with loss of teeth, vaginal granulomatosis, diabetes insipidus, multiple osteolytic bone lesions and honeycombing of the lungs. Skin biopsy confirmed the diagnosis. Treatment with prednisolone 45 mg methotrexate 2.5 mg daily, led to regression of lesions, reduction of bone of partial clearance of lung lesions and osteolytic bone lesions. However, the patient died due to widespread nature of the disease.

  6. Hand dermatitis: uncommon presentations.

    Science.gov (United States)

    Bauer, Andrea

    2005-01-01

    Hand dermatitis is a common diagnosis seen in dermatologic and general practice. It can present with typical morphology, but uncommon manifestations are possible. This review reports on common and uncommon presentations of irritant and allergic hand dermatitis focusing on uncommon localizations, time course, and morphology such as follicular, pustular, bullous, ulcerous, exudative erythema multiforme-like, purpuric, lichenoid, pigmented, and depigmented skin lesions. Clinical diagnosis can be challenging. Even histopathology is not always very helpful. Thorough evaluation of the patient's history and investigation of clinical morphology are the cornerstones of diagnosis.

  7. Lithium induced hidradenitis suppurativa and acne conglobata

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    Aithal Vijay

    2004-09-01

    Full Text Available Lithium is known to cause a variety of dermatological problems, common ones being acneiform eruptions, folliculitis and psoriasis including its pustular form. Hidradenitis suppurativa and acne conglobata are lesser known side effects, with only three reports so far. We report a patient, who had bipolar affective disorder, was on lithium for a long duration and developed hidradenitis suppurativa and acne conglobata during therapy, which subsequently decreased once lithium was stopped. We describe this case for its rarity and analyze its pathogenesis.

  8. Pseudomonas-follikulitis efter badning i spabad

    DEFF Research Database (Denmark)

    Uldall Pallesen, Kristine Appel; Andersen, Klaus Ejner; Mørtz, Charlotte Gotthard

    2012-01-01

    Pseudomonas aeruginosa is a rare cause of folliculitis. Pseudomonas folliculitis can develop after contact with contaminated water from swimming pools, hot tubs and spa baths. Systemic therapy may be indicated in patients with widespread lesions, systemic symptoms or in immunosuppressed patients....... We describe a 23-year-old healthy woman who developed a pustular rash and general malaise after using a spa bath contaminated with Pseudomonas aeruginosa. Bacterial culture from a pustule confirmed Pseudomonas folliculitis and the patient was treated with ciprofloxacin with rapid good effect....

  9. Sulphasalazine Induced Hypersensitivity Syndrome

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    Hatice Şanlı

    2013-05-01

    Full Text Available Drug-induced hypersensitivity syndrome (DIHS is one of the most dangerous drug reactions. Mortality and morbidity is increased by consequent systemic organ involvement. Maculopapular eruptions are the most common lesions accompanying DIHS, however, the morphology of skin lesions may vary. The most common cause of DIHS is the use of aromatic anticonvulsant drugs. However, one must not forget that other drugs may also cause DIHS. Early recognition of the condition is the most important step in the treatment. Herein, we present a case of DIHS triggered by sulphasalazine and associated with pustular eruption and maculopapular eruption.

  10. STAPHYLOCOCCAL SCALDED SKIN SYNDROME MIMICKING TOXIC EPIDERMAL NECROLYSIS IN A HEALTHY ADULT

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    Tomoko Oishi

    2013-07-01

    Full Text Available Introduction: Staphylococcal scaled skin syndrome (SSSS presents generalized form bullous impetigo caused by Staphylococcus aureus (S. aureus infection, typically seen in infants and children. SSSS may occur also in adults; however, the majority of adult cases are those with immunosuppression. Atypical clinical features of impetigo in adults sometimes make it difficult to diagnose correctly. Case Report: A 74-year-old healthy woman was hospitalized, complaining of extensive desquamative erythema and a number of erosions. She was administered oral antiviral drugs under suspicion of herpes zoster prior to 10 days. Initial diagnosis on the admission was toxic epidermal necrolysis (TEN due to antiviral tablets; however, steroid pulse therapy resulted in no effect. Bacterial culture yielded coagulase-positive methicillin-resistent S. aureus, producing exfoliative toxin B. A biopsy specimen showed subcorneal splitting of the epidermis. The diffuse erosions gradually improved over 10 days by the treatment with intravenous antibiotics. Conclusions: The differentiation between streptococcal scaled skin syndrome (SSSS and TEN is sometimes difficult. It is important to remind SSSS when we suspect TEN, even in healthy adults..

  11. Effectiveness of Photodynamic Therapy in the Healing of Corneal Alkali Burn in Rats

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    Akshay Khera

    2016-06-01

    Full Text Available In this study, we investigated the effect of photodynamic therapy (PDT on the healing of corneal alkali burns in rats. The experiment was performed on 50 adult non-linear rats. Depending on the intervention, the animals were divided into 5 equal groups with 10 animals in each group: Group 1 included rats with intact eyes (the control group and Groups 2 through 5 were experimental groups with EAB. Group 2 consisted of rats subjected to instillation of 0.25% chloramphenicol solution; Group 3 consisted of rats subjected to photodynamic irradiation according to our scheme: 300 mJ (630 nm for 3 minutes; Group 4 consisted of rats subjected to instillation of methylene blue (MB; Group 5 consisted of rats subjected to instillation of MB with subsequent photodynamic irradiation according to the described scheme. During all periods of observation, the infiltration of the subcorneal zone was less pronounced in Group 5 than in the other groups and was represented mainly by round cells in the anterior chamber, iris, retina, and ciliary zone. The instillation of MB with subsequent photodynamic irradiation was the most effective in reducing the bacterial contamination Thus, PDT with the photosensitizer methylene blue, in accordance with the designed exposure mode, provided the epithelialization and bacteriostatic effect during corneal repair after EAB. In conclusion, PDT improves a wound’s healing process, which is expressed in the reduction of inflammatory infiltration and the promotion of corneal epithelialization.

  12. Superficial Dsg2 Expression Limits Epidermal Blister Formation Mediated by Pemphigus Foliaceus Antibodies and Exfoliative Toxins

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    Donna Brennan

    2010-01-01

    Full Text Available Cell-cell adhesion mediated by desmosomes is crucial for maintaining proper epidermal structure and function, as evidenced by several severe and potentially fatal skin disorders involving impairment of desmosomal proteins. Pemphigus foliaceus (PF and staphylococcal scalded skin syndrome (SSSS are subcorneal blistering diseases resulting from loss of function of the desmosomal cadherin, desmoglein 1 (Dsg1. To further study the pathomechanism of these diseases and to assess the adhesive properties of Dsg2, we employed a recently established transgenic (Tg mouse model expressing Dsg2 in the superficial epidermis. Neonatal Tg and wild type (WT mice were injected with purified ETA or PF Ig. We showed that ectopic expression of Dsg2 reduced the extent of blister formation in response to both ETA and PF Ig. In response to PF Ig, we observed either a dramatic loss or a reorganization of Dsg1-α, Dsg1-β, and, to a lesser extent, Dsg1-γ, in WT mice. The Inv-Dsg2 Tg mice showed enhanced retention of Dsg1 at the cell-cell border. Collectively, our data support the role for Dsg2 in cell adhesion and suggest that ectopic superficial expression of Dsg2 can increase membrane preservation of Dsg1 and limit epidermal blister formation mediated by PF antibodies and exfoliative toxins.

  13. [Acute generalized exanthematous pustulosis].

    Science.gov (United States)

    Sidoroff, A

    2014-05-01

    Acute generalized exanthematous pustulosis (AGEP) is a reaction pattern mostly caused by drugs. It is characterized by the rapid occurrence of dozens to thousands pinhead-sized, non-follicular, sterile pustules on a slightly edematous erythematous base, commonly with accentuation in the major flexures and usually accompanied by a facial edema, fever and leukocytosis. Histology reveals spongiform subcorneal and/or intraepidermal pustules, an inflammatory infiltrate consisting of neutrophils and often eosinophils and frequently a marked edema of the papillary dermis. Even if in single case reports a large number of drugs has been described as triggers for AGEP, larger studies have revealed a list with an elevated risk to cause the reaction which includes antibacterial agents like ampicillin/amoxicillin, quinolones, pristinamycin, anti-infective sulfonamides, the antimycotic drug terbinafine, (hydroxy)chloroquine, and diltiazem. In some cases infections have been reported as triggers. AGEP is an acute and--especially in patients with concomitant diseases--sometimes severe reaction. Withdrawal of the causative agent usually leads to a rapid and complete resolution--even without further specific therapy.

  14. Recurrent impetigo herpetiformis successfully treated with methotrexate: a case report.

    Science.gov (United States)

    Luewan, Suchaya; Sirichotiyakul, Supatra; Tongsong, Theera

    2011-06-01

    Impetigo herpetiformis is a rare disease and its occurrence is specific for pregnancy. The lesions are characterized by sterile, pustular eruptions. The disorder is usually seen in the third trimester, but cases of impetigo herpetiformis appearing in the first trimester have also been reported. The lesions are expected to disappear after birth, but the disorder may recur during subsequent pregnancies. In this case report we discuss a 28-year-old pregnant woman, G3P1011, with a history of impetigo herpetiformis in the first pregnancy, who presented with generalized pustular lesions at 30 weeks' gestation. Her disease responded poorly to corticosteroids and was more severe than in the previous pregnancy. She delivered prematurely at 34 weeks' gestation and then received aggressive postpartum treatment with methotrexate, resulting in a dramatic response. This case supports the current understanding that recurrent impetigo herpetiformis in subsequent pregnancy tends to be more severe and to have an earlier onset. Additionally, it provides additional evidence that methotrexate may be used as an alternative treatment for impetigo herpetiformis in the case of a poor response to corticosteroids. © 2010 The Authors. Journal of Obstetrics and Gynaecology Research © 2010 Japan Society of Obstetrics and Gynecology.

  15. [Streptococcal impetigo at topical tacrolimus application sites in a woman with atopic dermatitis].

    Science.gov (United States)

    Reynaert, G; Rey, A-C; Graveriau, C; Hesse, S; Denoeux, J-P

    2007-03-01

    We report a case of staphylococcal impetigo in a girl treated with tacrolimus ointment (Protopic) for atopic dermatitis. A 15 year-old girl was receiving treatment with tacrolimus 0.03% (Protopic) for an episode of atopic dermatitis. On reduction of applications of tacrolimus, a vesicular-pustular rash appeared and was treated with pristinamycin and valaciclovir. At the end of antibiotic and antiviral therapy, the vesicular-pustular rash recurred while the goal was receiving treatment once more with tacrolimus ointment 0.1%. The bacteriological and virological skin samples revealed B-haemolytic streptococcus group A. The negative results for cutaneous virological samples ruled out Kaposi-Juliusberg syndrome and a diagnosis of staphylococcal impetigo was made. The intrinsic imputability of tacrolimus was I3 (C3 S2). The most obvious specific feature of this impetigo was its limitation to areas of eczema treated by application of tacrolimus. In prospective studies in large patient cohorts, tacrolimus ointment has been associated with two types of adverse effect: local irritations and skin infections chiefly caused by Staphylococcus aureus. To date, there have been no reports in the literature of impetigo due to haemolytic B streptococcus following application of tacrolimus. Because of its immunodepressant effect, tacrolimus ointment may result in increased incidence of skin infections even though a number of studies have shown a reduction in such infections.

  16. Acne phototherapy using UV-free high-intensity narrow-band blue light: a three-center clinical study

    Science.gov (United States)

    Shalita, Alan R.; Harth, Yoram; Elman, Monica; Slatkine, Michael; Talpalariu, Gerry; Rosenberg, Yitzhak; Korman, Avner; Klein, Arieh

    2001-05-01

    Propionibacterium. acnes is a Gram positive, microaerophilic bacterium which takes a part in the pathogenesis of inflammatory acne. P. acnes is capable to produce high amounts endogenic porphyrins with no need of any trigger molecules. Light in the violet-blue range (407-420 nm) has been shown to exhibit a phototoxic effect on Propionibacterium acnes when irradiated in vitro. The purpose of our study was to test the clinical effects of a high intensity narrowband blue light source on papulo pustular acne. A total of 35 patients in 3 centers were treated twice a week with a high intensity metal halide lamp illuminating the entire face (20x20 cm2) or the back with visible light in the 407-420 nm range at an intensity of 90 mW/cm2 (CureLight Ltd.) for a total of 4 weeks. UV is totally cut off. In each treatment the patient was exposed to light for 8-15 minutes. After 8 treatments, 80% of the patients with mild to moderate papulo-pustular acne showed significant improvement at reducing the numbers of non- inflammatory, inflammatory and total facial lesions. Inflammatory lesion count decrease by a mean of 68%. No side effects to the treatment were noticed. In conclusion, full face or back illumination with the high intensity pure blue light we used exhibits a rapid significant decrease in acne lesions counts in 8 biweekly treatments.

  17. Psoriasis in autoimmune polyendocrine syndrome type I: A possible complication or a non-endocrine minor component?

    Directory of Open Access Journals (Sweden)

    Shital Amin Poojary

    2015-01-01

    Full Text Available Introduction: Autoimmune polyendocrine syndrome type I (APS I is an autosomal recessive systemic autoimmune disorder, affecting primarily endocrine glands, in which chronic mucocutaneous candidiasis is an early and prominent manifestation. We describe the rare occurrence of unstable psoriasis (with onset of pustular lesions in a case of APS I without mucocutaneous candidiasis. A patient presenting with unstable psoriasis (with onset of pustular lesions was detected to have persistent hypocalcemia which led to the diagnosis of hypoparathyroidism. Subsequently he was found to have hypergonadotrophic hypogonadism, primary adrenal insufficiency (compensated, and coeliac disease, thus confirming the diagnosis of APS I. Psoriasis is very rarely reported in APS I, possibly due to the protective effect of antibodies to Th17 cytokines, which are responsible for the occurrence of candidiasis in this syndrome. However, psoriasis could occur in APS I patients without mucocutaneous candidiasis, who lack these antibodies. In our patient, possible factors aggravating psoriasis include hypocalcemia due to hypoparathyroidism as well as coeliac disease via anti-tissue transglutaminase antibodies. However, defining psoriasis as a possible minor component of APS I would require further studies of the autoimmune regulator (AIRE gene functions.

  18. Diversity of cyanobacterial biomarker genes from the stromatolites of Shark Bay, Western Australia.

    Science.gov (United States)

    Garby, Tamsyn J; Walter, Malcolm R; Larkum, Anthony W D; Neilan, Brett A

    2013-05-01

    Families of closely related chemical compounds, which are relatively resistant to degradation, are often used as biomarkers to help trace the evolutionary history of early groups of organisms and the environments in which they lived. Biomarkers derived from hopanoid variations are particularly useful in determining bacterial community compositions. 2-Methylhopananoids have been thought to be diagnostic for cyanobacteria, and 2-methylhopanes in the geological record are taken as evidence for the presence of cyanobacteria-containing communities at the time of sediment deposition. Recently, however, doubt has been cast on the validity of 2-methylhopanes as cyanobacterial biomarkers, since non-cyanobacterial species have been shown to produce significant amounts of 2-methylhopanoids. This study examines the diversity of hpnP, the hopanoid biosynthesis gene coding for the enzyme that methylates hopanoids at the C2 position. Genomic DNA isolated from stromatolite-associated pustular and smooth microbial mat samples from Shark Bay, Western Australia, was analysed for bacterial diversity, and used to construct an hpnP clone library. A total of 117 partial hpnP clones were sequenced, representing 12 operational taxonomic units (OTUs). Phylogenetic analysis showed that 11 of these OTUs, representing 115 sequences, cluster within the cyanobacterial clade. We conclude that the dominant types of microorganisms with the detected capability of producing 2-methylhopanoids within pustular and smooth microbial mats in Shark Bay are cyanobacteria. © 2012 Society for Applied Microbiology and Blackwell Publishing Ltd.

  19. Cutaneous allergic drug reactions: update on pathophysiology, diagnostic procedures and differential diagnosic.

    Science.gov (United States)

    Balakirski, Galina; Merk, Hans F

    2017-12-01

    Important changes in the understanding and management of drug hypersensitivity reactions during the last years result from the increasing importance of biologics in medical practice, which differ in their spectrum of adverse drug reactions (ADRs) from the classical covalent drugs. With regard to covalent drugs, ampicillin and amoxicillin as well as clavulanic acid play an increasing role among ADRs to betalactam antibiotics. Fluoroquinolones are mainly the cause of anaphylactic and photosensitivity reactions. Especially in allergic reactions to NSAIDs, pseudoallergic reactions should be considered in the differential diagnosis. In opposite to the main cutaneous allergic drug reactions such as urticaria or maculopapular skin rash, in which antibiotics are the main culprits, in severe drug allergic reactions such as SJS (Stevens-Johnson Syndrome), TEN (Toxic Epidermal Necrolysis), or DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) Syndrome, compounds like allopurinol and anticonvulsants are the main causes. Similar mutations in the IL36R gene, which were found in both patients with an AGEP (Acute Generalized Exanthematous Pustulosis) and pustular psoriasis, make the differential diagnosis more difficult and raise the question whether there is a difference between these diseases or whether AGEP is not just a drug induced pustular psoriasis. Finally, some special aspects of side effects of biologics and targeted therapies respectively are discussed.

  20. Rapid Involution of Pustules during Topical Steroid Treatment of Acute Generalized Exanthematous Pustulosis

    Directory of Open Access Journals (Sweden)

    Christiane Kley

    2017-04-01

    Full Text Available Acute generalized exanthematous pustulosis (AGEP is a dramatic generalized pustular rash of severe onset, which is considered a serious cutaneous adverse reaction to drugs. However, even though the clinical features are impressive and are often accompanied by systemic inflammation, it can be controlled quickly and safely by topical steroids subsequent to interruption of the offending drug. Here, we describe the management of a case and the evolution of the pustular rash. An elderly woman consulted with a generalized crop of 2–3 mm, nonfollicular pustules on erythematous background. In the 4 preceding weeks, she had been using amoxicillin/clavulanic acid for a bacterial implant infection and rivaroxaban. The clinical EuroSCAR criteria including the histology confirmed AGEP. Her medication was stopped and topical clobetasol propionate was used. Within 24 h, the development of new pustules ceased and the patient was discharged after 7 days of hospitalization with only a faint, diffuse erythema and focal desquamation remaining. This and many other cases in the literature suggest that topical steroids should be considered as a first-line treatment option, especially as systemic steroids themselves can sometimes induce generalized pustulosis.

  1. Agalychnis spurrelli Boulenger (Anura, Hylidae: variación, distribución y sinonimia

    Directory of Open Access Journals (Sweden)

    H. Mauricio Ortega-Andrade

    2008-01-01

    Full Text Available Agalychnis spurrelli Boulenger, 1913 es el nombre válido más reciente para una especie hylida de rana Phyllomedusina que habita los bosques tropicales de tierras bajas y premontanos del Pacífico, desde el sur de Costa Rica hasta el centro-occidente de Ecuador. Presento datos que apoyan la ubicación de Agalychnis litodryas Duellman & Trueb, 1967 como un sinónimo junior de A. spurrelli. Agalychnis spurrelli es una rana medianamente grande con extensas membranas interdigitales que se distingue de otras especies del género Agalychnis por tener los flancos y extremidades uniformemente amarillo, anaranjado, rosado pálido o morado pálido, sin barras oscuras. Su dorso es verde, comúnmente con verrugas pustulares bordeadas de negro.Agalychnis spurrelli Boulenger, 1913 is the earliest available name for a hylid species of Phyllomedusin frogs that inhabit the lowland and pre-montane tropical forests on the Pacific coast, from southern Costa Rica to central-western Ecuador. I present data that support the placement of Agalychnis litodryas Duellman & Trueb, 1967 as a junior synonym of A. spurrelli. Agalychnis spurrelli is a medium-large sized frog with extensive interdigital membrane that is distinguished from other species of the genus Agalychnis by having the flanks and limbs uniformly yellow, orange, pale rose or pale purple, without dark stripes. The dorsum is green, usually with black-bordered pustular white warts.

  2. Pioderma granulomatoso superficial: relato de caso de variante rara do pioderma gangrenoso Superficial granulomatous pyoderma: report of a case of an uncommon variant of pyoderma gangrenosum

    Directory of Open Access Journals (Sweden)

    Alceu Luiz Camargo Villela Berbert

    2009-07-01

    Full Text Available O pioderma gangrenoso é doença cutânea inflamatória rara, idiopática. Afeta principalmente adultos; apenas cerca de 4% dos casos são diagnosticados em crianças e adolescentes. Existem quatro formas clínicas de pioderma gangrenoso: ulcerativa, pustular, bolhosa e vegetante (pioderma granulomatoso superficial. O pioderma granulomatoso superficial é considerado a forma mais benigna e incomum da doença. Em pacientes submetidos a manipulação cirúrgica, uma eventual manifestação do pioderma gangrenoso ocorre nos locais de intervenção. Relata-se o caso de criança de cinco anos de idade, vítima de queimadura, que apresentou pioderma granulomatoso superficial sobre áreas doadoras de enxertos.Pyoderma gangrenosum is a rare idiopathic skin disease. It affects mainly adults, and only 4% of the cases are diagnosed on children and adolescents. There are four clinical forms of pyoderma gangrenosum: ulcerative, pustular, bullous, and vegetative (superficial granulomatous pyoderma. Superficial granulomatous pyoderma is considered the most benign and uncommon form of the disease. Patients who have undergone surgical procedures may occasionally present pyoderma gangrenosum manifestations on the surgical site. A case of a five-year-old child, victim of burn, who presented superficial granulomatous pyoderma on the skin graft donor sites is reported.

  3. Prevalência de dermatoses em idosos residentes em instituição de longa permanência Prevalence of dermatoses in residents of institutions for the elderly

    Directory of Open Access Journals (Sweden)

    Sandra Lopes Mattos e Dinato

    2008-12-01

    Full Text Available OBJETIVOS: Determinar a prevalência das afecções dermatológicas em 75 idosos residentes em instituição de longa permanência na cidade de Santos-SP, e confrontar os achados com revisão da literatura. MÉTODOS: Setenta e cinco idosos foram submetidos a exame dermatológico. Com os dados obtidos calculou-se a prevalência, o número médio por paciente e a freqüência de dermatoses. Foi ainda analisado a distribuição nos subgrupos sexo, raça, faixa etária e nos subgrupos principais de dermatoses. RESULTADOS: O número total de dermatoses diagnosticadas foi 280, o número médio por paciente foi 3,73 e o número total de tipos de dermatoses foi 32. A prevalência das principais dermatoses encontradas foi: melanose solar (53,3%, queratose seborréica (46,6%, onicomicose (37,3%, nevo rubi (33,3%, púrpura senil (29,3%, xerose (14,6%, escabiose (12,0% e neoplasia maligna (1,3%. A distribuição das dermatoses foi 70% (IC95%: 59% a 81% maior no sexo feminino do que no masculino. CONCLUSÃO: Apesar da pequena casuística, os dados obtidos são compatíveis com os poucos relatos disponíveis na literatura. Este estudo de prevalência definiu a distribuição de dermatoses em uma fração da população de idosos. Entretanto, os dados agregados de casuísticas subseqüentes podem permitir tornar os dados mais precisos, cuja relevância é indiscutível na orientação de medidas de saúde individual e coletiva.OBJECTIVE: To determine the prevalence of dermatoses in 75 elderly residents in an institution of long permanence in the city of Santos, and to compare findings with those in literature. METHODS: Seventy five healthy elderly persons were submitted to a dermatological exam. The prevalence, the average number per elderly person and the frequency of dermatoses were calculated from the data collected. An analysis was then made of the distribution in the subgroups of, gender, race, age bracket as well as of dermatosis in the main sub

  4. [Infective endocarditis in a dermatology unit].

    Science.gov (United States)

    Konstantinou, M-P; Valeyrie-Allanore, L; Lesprit, P; Terrazzoni, S; Ortonne, N; Roujeau, J-C; Bagot, M

    2009-12-01

    Although often clinically suspected, infectious endocarditis (IE) is frequently difficult to diagnose with certainty. Although the dermatological signs of endocarditis can vary, they must be routinely sought where there is a suspicion of IE. The aim of this study was to reveal the diversity of clinical manifestations of IE in a dermatology unit. This retrospective study was conducted between May 2006 and May 2007 and included all patients hospitalized in the dermatology unit in whom an IE was diagnosed according to the modified Duke criteria. Seven patients were included with a median age of 61 years. The reasons for hospital admission were: chronic ulcers (n=1), Sezary's syndrome (n=1), atopic dermatitis (n=1), epidermolysis bullosa acquisita (n=1) and purpura (n=1). Specific dermatological manifestations of IE included necrotic lesions on the lower limbs (n=2), purpura (n=5) and splinter haemorrhages (n=1). Blood cultures were positive in 3 cases (MSSA=2, MRSA=1). One patient had serological evidence of Coxiella burnetti IE. Cutaneous sources of IE were found in 6 cases, including acute dermohypodermitis or chronic dermatosis (3), peripheral venous catheter (n=2) and haemodialysis (n=1). Transthoracic echocardiography was negative in 6 patients, whereas transoesophageal echocardiography performed in 6 patients confirmed the diagnosis in 5 cases. The mean time to diagnosis was 21 days. Among these patients, 5 died after a mean period of 78 days. Diagnosing IE remains a clinical challenge and must be routinely considered in the presence of unusual dermatological findings such as purpura or distal necrosis, but also in patients with partially or poorly controlled chronic dermatosis, which comprise an underestimated potential source of IE. Physicians treating such patients must consider the risk of IE, especially in the event of chronic dermatosis or of an invasive cutaneous procedure involving affected skin.

  5. Morbid condition involving cardio-vascular, broncho-pulmonary, digestive and neural lesions in children and young adults after dietary arsenic exposure

    Energy Technology Data Exchange (ETDEWEB)

    Zaldivar, R.

    1980-02-01

    An investigation on the relationship between dietary arsenic exposure and cardiovascular diseases was made. In Antofagasta Commune, northern Chile, since 1955 arsenic has polluted public drinking water. This environmental contamination is of geological origin. The concentration of arsenic in drinking water for the 1955 to 1970 period was 0.5980 ppM. In the period June 1970 to March 1972, the concentration decreased to 0.0815 ppM due to a water filtration plant which started operating in May 1970. Greater Santiago showed 0.00 ppM of arsenic in drinking water. Amongst 10 autopsied patients with chronic arsenical dermatosis from Antofagasta Commune, 9 showed marked fibrous intimal thickening of the arterial wall and/or restricted lumen of the left coronary artery, 2 of these 9 also exhibiting myocardial infarction. Of the 10 patients, 7 developed cardiomegaly, which was related to chronic exposure to dietary arsenic. Two series of patients with myocardial infarction under 40 years of age, one from Antofagasta Commune, the other from greater Santiago (not exposed to arsenic) were compared. The Yates corrected chi 2 value being 11.7776. The difference was statistically highly significant. In Antofagasta Commune, the number of cases which had myocardial infarction with chronic arsenical dermatosis were compared with the cases which showed, myocardial infarction without chronic arsenical dermatosis. The Yates corrected chi 2 value was 13.0395. A highly significant difference was detected. Children from the two cities were also compared. The number of cases with myocardial infarction showed a significant difference; Fisher's exact test yielded a P approximately equal to 0.004944, the Yates corrected chi 2 value being 20.7311. The number of children with systemic occlusive arterial disease from the two cities also exhibited a highly significant difference.

  6. Bullous Mastocytosis Mimicking Congenital Epidermolysis Bullosa

    Directory of Open Access Journals (Sweden)

    Julio Cesar Salas-Alanis

    2014-05-01

    Full Text Available A 2-month-old female infant was referred to DebRA Mexico from the Regional Children's Hospital because of a generalized dermatosis from birth characterized by multiple blisters and erosions on the trunk, face and limbs, associated with minor trauma. A skin biopsy showing subepidermal blisters associated with a dermal infiltrate of Giemsa-positive cells and CD117-positive antibody was consistent with the diagnosis of bullous mastocytosis. Treatment with oral antihistamines, topical steroids, and antibiotics was initiated, leading to a remission of the lesions.

  7. Clinical disorders observed in a beagle breeding colony.

    Science.gov (United States)

    Fukuda, S; Iida, H; Oghiso, Y; Matsuoka, O

    1985-01-01

    Disorders in a beagle breeding colony were discussed, based on 472 clinical charts made in 1974-1983. In 201 neonates less than a week old, hypothermia associated with pneumonia was mostly seen. In 31 puppies from one week to two months old and in 46 young dogs from two months to a year old, pneumonia, canine parvovirus infection, dermal abscess and dermatosis were mostly found. In 91 dogs aged from one to five, trauma, intervertebral disc protrusion, dermal abscess, dystocia, claudication and otohematoma were frequently noted. In 103 animals over five years old, intervertebral disc protrusion, tumors, abscess, trauma and otohematoma were observed most often.

  8. NEUTROPHILIC MYOSITIS ASSOCIATED WITH PYODERMA GANGRENOSUM IN A BREAK-DANCER

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    Hisashi Tamiya

    2013-10-01

    Full Text Available Neutrophilic myositis is an extremely rare condition, cases of which have been reported in association with neutrophilic dermatosis, inflammatory bowel disease and malignant hematological disease. The disorder is histologically characterized by a sterile infiltration of neutrophils throughout muscle, with necrosis of muscle fibres. We here report the case of a young male who also had associated pyoderma gangrenosum, and who presented with necrotizing fasciitis-like manifestations. In this case, although there were no other underlying disorders, compulsive exertional stress due to break-dancing was thought to be a precipitant. Debridement of the necrotic tissues combined with oral corticosteroid treatment was effective.

  9. [Advances on investigation of chemical constituents, pharmacological activities and clinical applications of Capparis spinosa].

    Science.gov (United States)

    Yang, Tao; Liu, Yu-Qing; Wang, Chang-Hong; Wang, Zheng-Tao

    2008-11-01

    In this paper, the chemical constituents, pharmacological activities and clinical applications of Capparis spinosa had been reviewed. The constituents of C. spinosa include the saccharides and glycosides, flavonoids, alkaloids, terpenoids and volatile oils, fatty acids and steroides and so on. C. spinosa had many extensive pharmacological effects such as anti-inflammatory, odynolysis, antifungus, hepatoprotective effect, hypoglycemic activity, antioxidation, anti-hyperlipemia, anticoagulated blood, smooth muscle stimulation, anti-stress reaction, improve memory. It was used to treat arthrolithiasis, rheumarthritis and dermatosis in clinic in domestic, and it would have a broad application prospects.

  10. A case of erythema multiforme drug eruption associated with erythrodermic psoriasis induced by sofosbuvir and daclatasvir.

    Science.gov (United States)

    Wang, Y; Liu, P

    2017-02-01

    Sofosbuvir (SOF) and daclatasvir (DCV) have revolutionized the treatment of hepatitis C virus and now represent the preferred therapy for this disease. Limited data are available on the dermatological side effects resulting from co-administration of SOF and DCV. We report a case of an erythema multiforme drug eruption associated with erythrodermic psoriasis induced by SOF and DCV. After ceasing treatment, the skin condition significantly improved. We should pay attention to adverse skin reactions resulting from SOF and DCV, especially if the patient has a pre-existing dermatosis. © 2016 John Wiley & Sons Ltd.

  11. Epidermólisis ampollosa de la unión: implicación oral. A propósito de un caso Junctional epidermolysis bullosa: oral implication. A case report

    OpenAIRE

    A. Pipa Vallejo; E. López-Arranz Monje; M. González García; J. Ortiz Mauriz; M. Pipa Muñiz

    2010-01-01

    Se entiende por epidermólisis ampollosa un grupo de dermatosis no inflamatorias, mecano ampollosas, enfermedades clínicamente similares con afectación cutáneo mucosa, que tienen carácter hereditario, en general, y que se caracterizan por una excesiva fragilidad de la piel y mucosas ante pequeños o mínimos traumas mecánicos, dando lugar a la aparición de vesículas, ampollas, erosiones y escaras. Existe una gran variabilidad fenotípica y considerable morbimortalidad.Epidermolysis bullosa is the...

  12. [Causes of occupational allergy in dental nurses. An analysis based on the material collected at The Institute of Occupational Medicine in Lódź].

    Science.gov (United States)

    Kieć-Swierczyńska, M; Krecisz, B

    2000-01-01

    The causes of occupational dermatosis were analysed in 27 dental nurses examined at The Nofer Institute of Occupational Medicine during the years 1995-99. Contact sensitisation (at least one positive epidermal test) was found in 18 subjects (66.7%). Occupational allergic dermatitis was induced most frequently by: glutaraldehyde (7 positive patch tests), nickel (7), benzalkonium (4), formaldehyde (4), fragrances (4), chromium compounds (3), glyoxal (3), and thiuram (3). In the authors' opinion, dental nurses are nowadays sensitised to other chemical compounds than it used to be in the past. The present components of disinfectants (aldehydes, quaternary ammonium bases), metals and rubber are the major etiologic agents that induce occupational allergy.

  13. Granuloma faciale: a good therapeutic response with the use of topical tacrolimus.

    Science.gov (United States)

    Lima, Raquel Sucupira Andrade; Maquiné, Gustavo Ávila; Silva Junior, Renato Cândido da; Schettini, Antonio Pedro Mendes; Santos, Mônica

    2015-01-01

    Granuloma faciale is a rare dermatosis of chronic course, benign, usually asymptomatic, first described in 1945 by Wingley. It is characterized by the appearance of well-defined, single or multiple papules, plaques and nodules, predominantly located in sun-exposed areas, especially the face. In this work we report the case of a female patient, 58 years old, evolving for ten years with multiple erythematous-brownish and asymptomatic papules on the face, whose histological examination confirmed the diagnosis of granuloma faciale. The patient was treated with topical tacrolimus, evolving with regression of lesions.

  14. Granuloma faciale with subglottic eosinophilic angiocentric fibrosis: case report and review of the literature.

    Science.gov (United States)

    Nogueira, Ana; Lisboa, Carmen; Duarte, Ana F; Santos, Paulo; Portugal, Raquel; Canelhas, Aurea; Cardoso, Eduardo; Azevedo, Filomena

    2011-08-01

    Granuloma faciale (GF) is an uncommon inflammatory dermatosis that usually presents on the face as reddish brown or violaceous papules and nodules that may coalesce into plaques. Eosinophilic angiocentric fibrosis (EAF) is a rare fibrosing condition that shares many histologic characteristics with GF and is regarded by some authors as a mucosal counterpart of GF. We present a case of GF with concurrent EAF in a subglottic location with excellent response to an intralesional corticosteroid on the GF lesion, CO2 laser on the EAF lesion, and oral dapsone treatment.

  15. Photoletter to the editor: Dermoscopy of granuloma faciale.

    Science.gov (United States)

    Lallas, Aimilios; Sidiropoulos, Theodoros; Lefaki, Ioanna; Tzellos, Thrasivoulos; Sotiriou, Elena; Apalla, Zoe

    2012-06-30

    Granuloma faciale (GF) is a rare benign inflammatory dermatosis that usually develops as a solitary brownish-red plaque on the face. It clinically mimics and is often misinterpreted as, sarcoidosis, lupus erythematosus, lupus vulgaris, lymphoma or basal cell carcinoma.Dermoscopy, which is valuable for evaluation and differentiation between malignant and benign skin tumors, allows better visualization of dermal vascular structures and color variations. In this context, it might serve as an adjuvant diagnostic tool in the differentiation of inflammatory disorders, too. In the current manuscript, we present the dermoscopic features observed in a lesion of GF and discuss them in correlation with the underlying histopathological alterations.

  16. Granuloma faciale: a good therapeutic response with the use of topical tacrolimus*

    Science.gov (United States)

    Lima, Raquel Sucupira Andrade; Maquiné, Gustavo Ávila; da Silva Junior, Renato Cândido; Schettini, Antonio Pedro Mendes; Santos, Mônica

    2015-01-01

    Granuloma faciale is a rare dermatosis of chronic course, benign, usually asymptomatic, first described in 1945 by Wingley. It is characterized by the appearance of well-defined, single or multiple papules, plaques and nodules, predominantly located in sun-exposed areas, especially the face. In this work we report the case of a female patient, 58 years old, evolving for ten years with multiple erythematous-brownish and asymptomatic papules on the face, whose histological examination confirmed the diagnosis of granuloma faciale. The patient was treated with topical tacrolimus, evolving with regression of lesions. PMID:26560220

  17. Linear lichen planus in children - Case report*

    Science.gov (United States)

    Horowitz, Marcia Raquel; Vidal, Marcela de Lima; Resende, Manuela Oliveira; Teixeira, Márcia Almeida Galvão; Cavalcanti, Silvana Maria de Morais; de Alencar, Eliane Ruth Barbosa

    2013-01-01

    Lichen planus is an uncommon disease in children, and only 2 to 3% of affected patients are under twenty years of age. This dermatosis may appear in several clinical forms, which vary according to the morphology and distribution of lesions. In less than 0.2% of all lichen planus cases, the lesions are distributed along the lines of Blaschko, and is a variant called linear lichen planus. This is a case report of a patient aged two years and eight months, who presented keratotic violaceous papules, affecting the abdomen, buttocks and right thigh, distributed along the lines of Blaschko. Histopathological examination confirmed a diagnosis of linear lichen planus. PMID:24346902

  18. Acral acanthosis nigricans in a case of scleroderma

    Directory of Open Access Journals (Sweden)

    Mahendra M Kura

    2015-01-01

    Full Text Available Acanthosis nigricans (AN is a dermatosis characterized by velvety, papillomatous, brownish-black, hyperkeratotic plaques, typically on the intertriginous surfaces and neck. The majority (80% of AN occurs idiopathically or in benign conditions such as endocrinopathies like diabetes mellitus, polycystic ovary syndrome; metabolic syndrome and/or heritable disease. Malignancy-associated AN is rare. AN may rarely be associated with autoimmune diseases including systemic lupus erythematosus, due to antibodies to the insulin receptor, so-called type B insulin resistance. Here we report a case of AN in a case of diffuse progressive systemic sclerosis without evidence of insulin resistance.

  19. Interventional treatments for Hailey-Hailey disease.

    Science.gov (United States)

    Farahnik, Benjamin; Blattner, Collin M; Mortazie, Michael B; Perry, Benjamin M; Lear, William; Elston, Dirk M

    2017-03-01

    Hailey-Hailey disease or familial benign chronic pemphigus is a rare blistering dermatosis that is characterized by recurrent erythematous plaques with a predilection for the skin folds. For extensive Hailey-Hailey disease that is recalcitrant to conventional therapy, laser ablation, photodynamic therapy, electron beam radiotherapy, botulinum toxin type A, dermabrasion, glycopyrrolate, and afamelanotide have been reported as useful treatments, but comparative trials are lacking. This review discusses the various treatment modalities for Hailey-Hailey disease and a summary of the evidence for the most recommended treatments. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  20. [Dermatobia hominis furuncular myiasis in a man returning from Latin America: first imported case in Tunisia].

    Science.gov (United States)

    Kaouech, E; Kallel, K; Belhadj, S; Chaker, E

    2010-04-01

    Human cutaneous myiasis is a common dermatosis in tropical zones. The purpose of this report is to describe the first imported case of furuncular myiasis caused by Dermatobia hominis (human botfly) in Tunisia. The patient was a man returning from Bolivia. Furuncular myiasis was suspected based on epidemiological data and clinical examination showing pruriginous elevated lesions. Diagnosis was confirmed by identification of Dermatobia hominis larvae. Treatment was based mainly on manual removal of larvae. Since furuncular myiasis is unknown in Tunisia, it is important to remember this parasitic disease in differential diagnosis in patients presenting boil-like inflammatory papules following travel to Latin America.

  1. Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis.

    Science.gov (United States)

    Eichenfield, Lawrence F; Tom, Wynnis L; Chamlin, Sarah L; Feldman, Steven R; Hanifin, Jon M; Simpson, Eric L; Berger, Timothy G; Bergman, James N; Cohen, David E; Cooper, Kevin D; Cordoro, Kelly M; Davis, Dawn M; Krol, Alfons; Margolis, David J; Paller, Amy S; Schwarzenberger, Kathryn; Silverman, Robert A; Williams, Hywel C; Elmets, Craig A; Block, Julie; Harrod, Christopher G; Smith Begolka, Wendy; Sidbury, Robert

    2014-02-01

    Atopic dermatitis (AD) is a chronic, pruritic, inflammatory dermatosis that affects up to 25% of children and 2% to 3% of adults. This guideline addresses important clinical questions that arise in the management and care of AD, providing updated and expanded recommendations based on the available evidence. In this first of 4 sections, methods for the diagnosis and monitoring of disease, outcomes measures for assessment, and common clinical associations that affect patients with AD are discussed. Known risk factors for the development of disease are also reviewed. Copyright © 2013 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  2. Guidelines of care for the management of atopic dermatitis: section 3. Management and treatment with phototherapy and systemic agents.

    Science.gov (United States)

    Sidbury, Robert; Davis, Dawn M; Cohen, David E; Cordoro, Kelly M; Berger, Timothy G; Bergman, James N; Chamlin, Sarah L; Cooper, Kevin D; Feldman, Steven R; Hanifin, Jon M; Krol, Alfons; Margolis, David J; Paller, Amy S; Schwarzenberger, Kathryn; Silverman, Robert A; Simpson, Eric L; Tom, Wynnis L; Williams, Hywel C; Elmets, Craig A; Block, Julie; Harrod, Christopher G; Begolka, Wendy Smith; Eichenfield, Lawrence F

    2014-08-01

    Atopic dermatitis is a chronic, pruritic inflammatory dermatosis that affects up to 25% of children and 2% to 3% of adults. This guideline addresses important clinical questions that arise in atopic dermatitis management and care, providing recommendations based on the available evidence. In this third of 4 sections, treatment of atopic dermatitis with phototherapy and systemic immunomodulators, antimicrobials, and antihistamines is reviewed, including indications for use and the risk-benefit profile of each treatment option. Copyright © 2014 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  3. Approach to Immunization for the Traveling Child.

    Science.gov (United States)

    Myers, Angela L; Christenson, John C

    2015-12-01

    Children are traveling to regions of the world that could pose a risk of acquiring diseases such as malaria, dermatosis, and infectious diarrhea. Most of these can be prevented by modifying high-risk behaviors or through the use of medications. Many of these same regions are endemic with diseases that are preventable through vaccination. Clinicians must be able to effectively prepare their pediatric-age travelers for international travel. Preventive education, prophylactic and self-treating medications, and vaccinations are all important components of this preparation. Familiarity with the use of travel vaccines is imperative. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. Top Ten List of Clinical Pearls in the Treatment of Acne Vulgaris.

    Science.gov (United States)

    Layton, Alison M

    2016-04-01

    Acne represents the most common inflammatory dermatosis seen worldwide and is the leading reason for seeing a dermatologist. This article provides some tips for managing acne in a safe and effective manner to minimize the physical and psychological scars that can result from acne. Tips include how to optimize available treatment regimens according to the evidence base and target therapy to pathophysiologic factors, while also tailoring treatments to patient expectation and needs. Attention is given to minimizing the emergence of antimicrobial resistance in acne patients and beyond. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. Adjuvant therapy of patients with chronic dermatoses using Bedan cream

    Directory of Open Access Journals (Sweden)

    Y.F. Kutasevych

    2016-02-01

    Full Text Available The paper is devoted to the problem of treatment of chronic dermatopathies. There are demonstrated the data of study of therapeutic efficiency and tolerance of Bedan cream I patients with dermatopathies. Bedan cream used in a complex therapy of chronic dermatopathies was shown to lead to earlier reduction of objective and subjective signs of chronic dermatosis and clinical regression. It was found a good tolerance of Bedan cream: its application was not associated with deterioration of general condition of skin, its irritation and allergization.

  6. CELULITS EOSINOFÍLICA (SINDROME DE WELLS. A PROPÓSITO DE UN CASO

    Directory of Open Access Journals (Sweden)

    Corrales Cruz D

    2014-01-01

    Full Text Available The "Wells syndrome" is a rare inflammatory dermatosis of unknown pathogenesis, clinical polymorph, both the location and the extent of the lesions. This is a skin disease of inflammatory origin, which usually appears in children and adolescents. Has a polymorphic clinical picture, both the location and the extent of the lesions, and for the correct interpretation of diagnostic histopathological lesions required. This entity should be considered in the differential diagnosis of any atypical presentation of cellulite with peripheral eosinophilia, that does not respond to antibiotics.

  7. Dowling-Degos disease--a heat aggravated variant.

    Science.gov (United States)

    Kossard, S; Krivanek, J

    2001-08-01

    A 22-year-old woman presented with a 5-year history of a micropapular eruption localized to the flexor aspect of her limbs as well as persistent reticulate pigmentation of her neck and upper chest resembling Darier's disease. The eruption was associated with pruritus that was precipitated by heat and was worse in summer. The axillae, groins and inframammary areas had multiple papules but lacked reticulate pigmentation. Multiple biopsies showed an epidermis with club- and antler-like rete ridges but no acantholysis or dyskeratosis. This distinct clinical presentation may represent an unusual heat aggravated variant of Dowling-Degos disease that clinically shares features with Darier's disease and transient acantholytic dermatosis.

  8. GUIDELINES OF CARE FOR THE MANAGEMENT OF ATOPIC DERMATITIS

    Science.gov (United States)

    Eichenfield, Lawrence F.; Tom, Wynnis L.; Chamlin, Sarah L.; Feldman, Steven R.; Hanifin, Jon M.; Simpson, Eric L.; Berger, Timothy G.; Bergman, James N.; Cohen, David E.; Cooper, Kevin D.; Cordoro, Kelly M.; Davis, Dawn M.; Krol, Alfons; Margolis, David J.; Paller, Amy S.; Schwarzenberger, Kathryn; Silverman, Robert A.; Williams, Hywel C.; Elmets, Craig A.; Block, Julie; Harrod, Christopher G.; Begolka, Wendy Smith; Sidbury, Robert

    2014-01-01

    Atopic dermatitis (AD) is a chronic, pruritic inflammatory dermatosis that affects up to 25% of children and 2–3% of adults. This guideline addresses important clinical questions that arise in AD management and care, providing updated and expanded recommendations based on the available evidence. In this first of four sections, methods for diagnosis and monitoring of disease, outcomes measures for assessment and common clinical associations that affect patients with AD are discussed. Known risk factors for the development of disease are also reviewed. PMID:24290431

  9. Sweet's syndrome in association with common variable immunodeficiency.

    LENUS (Irish Health Repository)

    O'Regan, G M

    2009-03-01

    Sweet\\'s syndrome (SS), a rare reactive neutrophilic dermatosis, has been reported to occur in association with a variety of systemic disorders, categorized by von den Diesch into idiopathic, paraneoplastic, pregnancy and parainflammatory subgroups. The parainflammatory group has been well defined, and includes a wide spectrum of infectious triggers and disorders of immune dysregulation. To date, however, no cases of SS have been described in the context of common variable immunodeficiency (CVID). We report a case of paediatric-onset SS, previously reported as idiopathic, with a subsequent diagnosis of CVID.

  10. Pityriasis Rosea in a Woman and Her Husband – Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Natalya Lemster

    2010-08-01

    Full Text Available Pityriasis rosea is an acute, self-limited papulosquamous dermatosis of the trunk and extremities. Many atypical forms of the disease have been reported in the literature [Ahmed et al.: Clin Exp Dermatol 2000;25:624–626; Imamura et al.: Dermatologica 1985;171:474–477]. It is rare to find pityriasis rosea in multiple family members (within a household at the same time. There have been only 4 reported cases where a couple has contracted pityriasis rosea simultaneously [Miller et al.: Arch Derm Syphilol 1941;44:66–68; Niles et al.: Arch Derm Syphilol 1940;41:264].

  11. Creeping eruption of the hand in an Iranian patient: Cutaneous larva migrans

    Directory of Open Access Journals (Sweden)

    Zabihollah Shahmoradi

    2014-01-01

    Full Text Available Cutaneous larva migrans (CLM, a serpiginous cutaneous eruption is the most commonly acquired tropical dermatosis. It is caused by infection with hookworm larvae in tropical and sub-tropical areas, and people who have a history of travel in these countries. The most frequent location of CLM is the distal lower extremities or buttocks. We describe a case of 57-year-old Iranian female patient with CLM of hand (unusual site without traveling to endemic countries that was successfully treated with oral albendazole. To the best of our knowledge, this is the first report of CLM in Iran.

  12. Drug: D00381 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00381 Drug Tolnaftate (JP16/USP/INN); Separin (TN); Tinactin (TN) C19H17NOS 307.10... individual organs 26 Epidermides 265 Antiparasitic dermatosis agents 2659 Others D00381 Tolnaftate (JP16/US...r topical use D01AE18 Tolnaftate D00381 Tolnaftate (JP16/USP/INN) Antiinfectives [BR:br08307] Antifungals Er...gosterol biosynthesis inhibitor squalene epoxidase inhibitor [KO:K00511] Thiocarbamates Tolnaftate [ATC:D01AE18] D00381 Tolnafta

  13. Cutaneous silica granuloma. A rare entity or rarely diagnosed Report of two cases with review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Mowry, R.G.; Sams, W.M. Jr.; Caulfield, J.B. (Univ. of Alabama, Birmingham (USA))

    1991-05-01

    Cutaneous silica granuloma is a poorly understood, uncommon condition that may mimic cutaneous sarcoidosis. We describe two cases of this entity and their characteristic latency period (between the time of silica exposure to the time of clinical onset of granuloma). We also review the histologic and energy dispersive x-ray analysis data, which prove the diagnosis. This condition should be recognized as an occupational dermatosis as well as the result of past incidental cuts or abrasions, which result in the development of granulomas, many in old wound scars. Differentiation from cutaneous sarcoidosis is possible with polarized light microscopy and energy-dispersive x-ray analysis.15 references.

  14. Kaposi′s varicelliform eruption

    Directory of Open Access Journals (Sweden)

    Shenoy Manjunath

    2007-01-01

    Full Text Available Kaposi′s varicelliform eruption (eczema herpeticum is the name given to a distinct cutaneous eruption caused by herpes simplex and certain other viruses that infect persons with preexisting dermatosis. Most commonly it is associated with atopic dermatitis. We report a case of a three-year-old atopic child who presented with extensive vesicular eruption suggestive of Kaposi′s varicelliform eruption. There was history of fever, malaise and extensive vesicular eruptions. Diagnosis was made based on clinical features and Tzanck smear examination. Patient responded adequately to oral acyclovir therapy.

  15. Wells′ syndrome

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    Chaudhary Ajay

    1997-01-01

    Full Text Available Eosinophilic cellulitis/Wells′ syndrome is a rare dermatosis with erythematous, urticarial plaques that become more indurated and eventually have grey blue discoloration. The histopathology is distinctive, with a diffuse infiltrate composed predominantly of eosinophils but admixed with lymphocytes, histicytes and occasionally multinucleated histiocytes. There is dermal edema with so called "flame figures" that is composed of collagen focally enveloped with aggregates of eosinophilic granules. These collagen fibres may be surrounded by palisading histiocyes. The course is variable with waxing and waning and eventual spontaneous resolution.

  16. Extragenital lichen sclerosus et atrophicus

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    Leelavathy Ganesan

    2015-01-01

    Full Text Available Lichen sclerosus et atrophicus (LSA is a chronic inflammatory dermatosis with anogenital and extragenital presentations. Extragenital lichen sclerosus is most common on the neck, shoulders and upper trunk. Linear lesions are uncommon in LSA. We report a case of linear extragenital LSA involving forehead and scalp, along with grouped white papules of LSA in the right side of the back in a postmenopausal woman. The patient showed atypical clinical presentation of LSA in face which clinically mimicked ′en coup de sabre′ as seen in morphea, but other clinical features suggested the diagnosis of LSA and the histopathological findings confirmed it.

  17. Ichthyosiform scaling secondary to megavoltage radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Ross, E.V. (National Naval Medical Center, Bethesda, MD (USA))

    1991-07-01

    Acquired ichthyosis is a rare dermatosis associated with a number of malignancies. Side effects seen on the skin secondary to megavoltage radiotherapy are uncommon but may include fine dry desquamation and tanning. The authors present a case of ichthyosiform scaling limited to the radiation fields in a patient treated for brain metastases of a primary small cell lung carcinoma. The reader is reminded that side effects of megavoltage treatment do occur on the skin. A brief review of these effects is included. 5 references.

  18. Criptococosis cutánea primaria en paciente inmunocompetente

    OpenAIRE

    Vázquez-Osorio, Igor; García-Rodiño, Sara; Rodríguez-Rodríguez, Marta; Labandeira, Javier; Suárez-Peñaranda, José Manuel; Sánchez-Aguilar, MDolores; Vázquez-Veiga, Hugo

    2016-01-01

    La criptococosis cutánea es una micosis propia de pacientes inmunodeprimidos, sobre todo aquellos con infección por el virusde la inmunodeficiencia humana (VIH). Sin embargo, existen casos infrecuentes de criptococosis cutánea en pacientes inmunocompetentes, que suelen simular otras dermatosis, lo que retrasa su diagnóstico y tratamiento. Presentamos el caso de un varón pluripatológico de 79 años, con úlceras dolorosas en dorso de mano derecha que no respondían a tratamientos tópicos. A travé...

  19. Resolution of inverse psoriasis after treatment with levodopa for Parkinson's disease.

    Science.gov (United States)

    Rojo Suárez, Natalia; Jiménez Gallo, David; Arjona Aguilera, Cintia; Espinosa Rosso, Raúl; Linares Barrios, Mario

    2017-01-01

    Inverse psoriasis is characterized by the development of erythematous shiny plaques at intertriginous areas of the body. It has a prevalence of 2% worldwide. The usefulness of levodopa in psoriasis was discovered in 1970 but nowadays it is not a standard therapy for this condition. A 74-year-old woman was diagnosed with Parkinson's disease subsequent to the development of extensive inverse psoriasis. The skin lesions were resistant to classical topical and systemic medications. Treatment with levodopa was initiated in order to treat her neurological problem and progressive remission of the skin lesions was noted. We highlight the role of dopamine in the pathophysiology of this dermatosis. © 2016 Wiley Periodicals, Inc.

  20. Granuloma faciale successfully treated with ingenol mebutate.

    Science.gov (United States)

    Bobyr, I; Campanati, A; Consales, V; Giangiacomi, M; Diotallevi, F; Offidani, A

    2016-09-01

    Granuloma faciale (GF) is a rare chronic inflammatory dermatosis of unknown etiology, characterized by leukocitoclastic vasculitis usually occurring on the face. We report a case of 60-years-old man with 3 year history of multiple actinic keratoses (AK) and persistent asymptomatic erythematous papules and plaques located over his left temporal region and the cheek: histopathology was consistent with GF. Herein we describe the successful treatment of the lesion with ingenol mebutate 0.015% gel focusing on the clinical, dermoscopic and histopathological findings of GF both before and after treatment. © 2016 Wiley Periodicals, Inc.

  1. [Systemic urticaria in 2014].

    Science.gov (United States)

    Doutre, M-S

    2014-11-01

    Systemic urticaria are defined as urticaria, most often chronic, associated with systemic diseases. At present time, urticarial vasculitis and neutrophilic urticarial dermatosis associated to autoinflammatory syndromes are not considered to be subtypes of chronic spontaneous urticaria due to their distinctly clinical and histological characteristics as well different pathomechanisms. Sometimes, chronic urticaria is associated to thyroid autoimmunity. However, the majority of cases of chronic spontaneous urticaria have no discernible cause and further investigations are not necessary, as already suggested by some authors and French consensus conference more than 10 years ago. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  2. A woman with juxta-articular nodules—An uncommon form of subcutaneous granuloma annulare

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    Lili Wang

    2014-06-01

    Full Text Available Granuloma annulare is a benign inflammatory dermatosis that is most common in children and young adults. The subcutaneous form of granuloma annulare, which occurs mainly on the extremities in children, is rare. Lesions usually occur as painless subcutaneous nodules without inflammation of the cutaneous surface; the most frequent sites are the legs, buttocks, and scalp. Nevertheless, we present a case of subcutaneous granuloma annulare confined to the dorsa of the hand joints and right knee in a 51-year-old woman.

  3. Erythema dyschromicum perstans in a Caucasian pediatric patient.

    Science.gov (United States)

    Tisack, Alison M; Huggins, Richard H; Lim, Henry W

    2013-07-01

    Erythema dyschromicum perstans (EDP), or ashy dermatosis, is characterized by oval, blue-gray macules, which are completely asymptomatic. In adults, the condition is primarily seen in patients of color, most commonly those of Hispanic descent, and typically follows a chronic course. We describe a pediatric case of EDP in a Caucasian patient. In the pediatric population, EDP is more commonly observed in Caucasian patients and often shows significant recovery or complete resolution in a matter of years. This case report outlines the differences in EDP between adult and pediatric patients.

  4. Old condition caused by modern technology - erythema ag igne

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    Sara Ferreira

    2016-02-01

    Full Text Available Introduction:Erythema ab igne is a rare reticular pigmented dermatosis, caused by prolonged and repeated exposure to heat. Multiple heat sources have been reported to cause this condition, as fire or stove in proximity with the skin. Case report:We report a case of a diabetic teenager with erythema ab igne induced by a laptop computer. Conclusions: Laptop induced erythema ab igne is an underdiagnosed clinical entity. In the future maybe it will be more frequent due to the improper use of these devices. The possible irreversibility of skin lesions and the potential severe complications reinforce the need to be aware for this disease.

  5. Tips and tricks in the dermoscopy of pigmented lesions.

    Science.gov (United States)

    Kaminska-Winciorek, Grazyna; Spiewak, Radoslaw

    2012-08-24

    Dermoscopy is a useful, widely used tool for examining pigmented lesions, especially helpful in cases of an uncertain nature. Nevertheless, doctors may experience diagnostic difficulties while using this method. An example of this may be found in the examination of subcorneal hematoma, dark nevi with black lamella or lesions of acral volar skin. In such cases, a few diagnostic tricks have proven to be helpful in achieving diagnostic accuracy. This paper reviews various methods of performing dermoscopy, suggesting a number of simple, yet helpful tests. These include the adhesive tape test, the skin scraping test and the ink furrow test. The adhesive tape test is helpful in differentiating between dark melanocytic nevi and melanoma. Hematoma may be more easily differentiated with the use of the so-called skin scraping test. The confirmation of benign and melanocytic lesions of acral volar skin, on the other hand, is more accurate when using the ink furrow test. These methods have been discussed here based upon a series of literature reviews, the authors' own experience and, also, iconography. The present article describes novel methods used in dermoscopy, helping to bring about a faster, more accurate diagnostics of those lesions which have proven to be more difficult to recognize. Helpful tricks, such as have been known to professional literature, as well as the authors' own experience (for instance, applying urea cream to hyperkeratotic lesions or using photographs of skin lesions taken with the aid of a mobile phone camera--all prior to surgery) will surely be considered beneficial to the practitioner, be it dermatologist or any other physician.

  6. Impetigo presenting as an acute necrotizing swelling of the lower lip in an adult patient.

    Science.gov (United States)

    Ghafoor, Mohammed; Halsnad, Moorthy; Fowell, Christopher; Millar, Brian G

    2012-06-01

    The authors present an unusual case of an acute swelling of the lower lip and septicemia in a 35-year-old, recent immigrant male arriving from India. The patient presented in our emergency department with a 48-hour history of a worsening, painful swelling of the lower lip. On presentation, he was pyrexial and the lip was found to be acutely inflamed with honey-colored crusting, pustular lesions, and induration . A diagnosis of impetigo leading to necrosis of the lip was established, a rare phenomenon potentially resulting in significant tissue destruction. Appropriate medical management achieved a good outcome and prevented disabling tissue loss of the orofacial region. Copyright © 2012 Elsevier Inc. All rights reserved.

  7. A CLINICAL STUDY OF PHYSIOLOGICAL SKIN CHANGES IN NEONATAL PERIOD

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    Balachandran Parapattu Kunjukunju

    2017-05-01

    Full Text Available BACKGROUND The objective of this study was to find out physiological skin changes in newborns during the first 3 days of life. MATERIALS AND METHODS Around 1000 neonates were studied during the first three days at Government T D Medical College, Alappuzha, Kerala for a period of one year from January 2013 to December 2013. RESULTS Physiological skin changes seen were the commonest neonatal dermatoses, followed by transient non-infective cutaneous changes. Mongolian spot and Epstein pearl were the commonest among the physiological skin changes followed by sebaceous gland hyperplasia, physiological scaling, vernix caseosa, and sucking pads. The commonest transient non-infective cutaneous changes were erythema toxicum neonatorum, milia, transient pustular melanosis, neonatal cephalic pustulosis, eosinophilic pustulosis and infantile acropustulosis. CONCLUSION The common cutaneous change among neonates are mainly physiological and they are transient, self-limiting.

  8. Eczema in Psoriatico: An Important Differential Diagnosis Between Chronic Allergic Contact Dermatitis and Psoriasis in Palmoplantar Localization.

    Science.gov (United States)

    Kolesnik, Malgorzata; Franke, Ingolf; Lux, Anke; Quist, Sven R; Gollnick, Harald P

    2018-01-12

    Differential diagnosis of palmoplantar non-pustular psoriasis and chronic allergic contact dermatitis (ACD) and the combination of these conditions, termed "eczema in psoriatico" (EIP), is difficult, especially in cases of isolated involvement. A blind re-evaluation of 63 archived formalin-fixed palmoplantar samples, previously diagnosed clinically as either psoriasis or chronic ACD, was performed. Samples were allocated to histopathological diagnoses of psoriasis, contact dermatitis or EIP. Immunohistological stainings were performed for better characterization. Immunochemistry of EIP revealed features that overlapped contemporarily with psoriasis (cytokeratin 17 (CK17), Ki67, interleukin (IL)-8, IL-17, IL-23) and with ACD (CD1a, major histocompatibility complex (MHC) class I, MHC class II, epidermal T-cell subsets). Surprisingly, a significantly much higher number of dermal CD8+ T cells was found in EIP than in ACD and psoriasis. In conclusion, this study provides insight into the immunohistological differentiation of palmoplantar psoriasis, chronic ACD and EIP.

  9. Infectious agents in the pathogenesis of rosacea

    Directory of Open Access Journals (Sweden)

    Dorota M. Mehrholz

    2016-09-01

    Full Text Available Acne rosacea is a chronic inflammatory skin disease that affects the face. The symptoms depend on the stage of the disease. The first stage is characterized by erythema and telangiectasia. This is followed by a papulopustular phase and a phymatous type in the final stages. An ocular type of rosacea is described in the literature as well. In the etiopathogenesis of papulo-pustular and ocular types of rosacea, inflammatory response modulation caused by microorganisms living on the skin play a key role. Binding of bacterial ligands with epidermal receptors leads to induction of the inflammatory cascade. This leads to vasodilation and white blood cell chemotaxis, which causes a change in the microenvironment of the skin that assists in microorganism proliferation. Microorganisms such as Demodex folliculorum, Bacillus oleronius, Staphylococcus epidermidis, Chlamydia pneumoniae and Helicobacter pylori play a crucial role in the pathogenesis of rosacea.

  10. SAPHO syndrome: the clinical case

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    T. P. Makarova

    2017-01-01

    Full Text Available Syndrome Sapho is a combination of hyperostosis of the sternoclavicular joint with pustulosis of the palms and/or plants, pustular/vulgar psoriasis, or deep acne, which also celebrates spinal cord injury, osteitis and arthritis, including sacroiliitis. As trigger factors, the role of infections, such as Staphylococcus epidermidis, streptococci and viruses, is considered. They are associated with autoimmune post- or parainfectious pathogenesis of the SAPHO syndrome. As with the other seronegative spondyloarthritis important for the pathogenesis of SAPHO syndrome is a factor in hypothermia. Presents a clinical case of the syndrome of Sappho from the group of seronegative spondyloarthritis. Features of the course, the complexity of diagnosis in a particular patient and the possibility of targeted therapy with genetically engineered drugs, are shown.

  11. The Coexistence of Coeliac Disease, Psoriasis and Vitiligo

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    Sevgi Akarsu

    2010-06-01

    Full Text Available It has been defined that coeliac disease is associated with most of the autoimmune diseases including psoriasis and vitiligo. Here, a 26-year-old woman who was diagnosed palmoplantar pustular psoriasis and already had coeliac disease and vitiligo is reported. According to our opinions, this is the first report describing the development of these three disorders in one patient, even though vitiligo, psoriasis and coeliac disease are common disorders, and the coexistence of the two of them has been previously reported in the literature. This case has been presented to emphasize the importance of considering and inquiring the possible coeliac disease in chronic and autoimmune dermatoses, although psoriasis and vitiligo may have coincidental associations with coeliac disease.

  12. Acrodermatitis Enteropathica: A Case Report.

    Science.gov (United States)

    Nistor, Nicolai; Ciontu, Lavinia; Frasinariu, Otilia-Elena; Lupu, Vasile Valeriu; Ignat, Ancuta; Streanga, Violeta

    2016-05-01

    Acrodermatitis enteropathica is a rare genetic autosomal recessive disorder, characterized by periorificial dermatitis, alopecia, and diarrhea. It is caused by mutations in the gene that encodes a membrane protein that binds zinc. We report a 14-month-old boy, admitted for erythematous, scaly and pustular lesions, initially located in the inguinal and perianal regions and on thighs, and very few erythematous lesions on the face. Due to the numerous bacterial skin superinfections with Staphylococcus aureus, including abscesses that required surgical incision, the clinical picture was modified, leading to a delayed establishment of the diagnosis. Later, the symptoms became suggestive for this disease, the diagnostic having been confirmed by low plasma zinc values. Under zinc therapy, skin lesions improved significantly in a few days, with favorable outcome. Two months later, the skin lesions almost disappeared.Abscesses due to bacterial skin superinfections may lead to initially misdiagnosed acrodermatitis enteropathica.

  13. Acrodermatitis Enteropathica

    Science.gov (United States)

    Nistor, Nicolai; Ciontu, Lavinia; Frasinariu, Otilia-Elena; Lupu, Vasile Valeriu; Ignat, Ancuta; Streanga, Violeta

    2016-01-01

    Abstract Acrodermatitis enteropathica is a rare genetic autosomal recessive disorder, characterized by periorificial dermatitis, alopecia, and diarrhea. It is caused by mutations in the gene that encodes a membrane protein that binds zinc. We report a 14-month-old boy, admitted for erythematous, scaly and pustular lesions, initially located in the inguinal and perianal regions and on thighs, and very few erythematous lesions on the face. Due to the numerous bacterial skin superinfections with Staphylococcus aureus, including abscesses that required surgical incision, the clinical picture was modified, leading to a delayed establishment of the diagnosis. Later, the symptoms became suggestive for this disease, the diagnostic having been confirmed by low plasma zinc values. Under zinc therapy, skin lesions improved significantly in a few days, with favorable outcome. Two months later, the skin lesions almost disappeared. Abscesses due to bacterial skin superinfections may lead to initially misdiagnosed acrodermatitis enteropathica. PMID:27196457

  14. Acute generalized exanthematous pustulosis: report of 12 cases and literature review.

    Science.gov (United States)

    Guevara-Gutierrez, Elizabeth; Uribe-Jimenez, Elia; Diaz-Canchola, Margarita; Tlacuilo-Parra, Alberto

    2009-03-01

    Acute generalized exanthematous pustulosis is an acute pustular eruption occurring after infection and/or drug ingestion, with spontaneous cure after a single eruption. To communicate a series of cases of acute generalized exanthematous pustulosis. A retrospective analysis was performed on cases of acute generalized exanthematous pustulosis, observed between 1993 and 2006 at the Dermatology Department, Hospital General de Occidente, Jalisco, Mexico. Twelve patients were included, with a predominance of male patients and a mean age of 28 years. The most common cause was drugs, detected in 83% of cases, and most of these were a result of anticonvulsants and antimicobials. The most frequent symptoms were itching, present in all cases, and fever, present in 92% of cases. Acute generalized exanthematous pustulosis is considered to be a distinct clinical and histopathologic entity. Because of its self-resolving character, early recognition can help to avoid unnecessary diagnostic studies and treatments.

  15. A CASE OF SUBCUTANEOUS PHAEOHYPHOMYCOSIS CAUSED BY EXSEROHILUM SPECIES IN AN IMMUNOCOMPROMISED PATIENT

    Directory of Open Access Journals (Sweden)

    Koppada Rajasekhar

    2013-10-01

    Full Text Available Phaeohyphomycoses are rare fungal infections, caused by dematiaceous fungi, manifested as cutaneous and subcutaneous infections, meningitis, sinusitis, keratitis, osteomyelitis and disseminated infection. This is a case report of a 45year old immuno compromised female on ART (Anti Retroviral therapy presented with fever and generalized nodular lesions draining pus on face, hands, axilla, groin and labia majora since one month. Biopsy of the subcutaneous nodule on the lateral aspect of the thigh revealed septate fungal hyphae on 10% KOH (10% Potassium Hydroxide mount. Fungal culture of the biopsy material on SDA (Sabouraud’s Dextrose Agar at 250C showed cotton wooly, dark gray to olivaceous black growth with black reverse and identified as dematiaceous fungi belonging to Exserohilum species by microscopy. The patient was put on Itraconazole 200mg BD in combination with Terbinafine 250mg BD for which she responded with healing of pustular lesions in two weeks and complete remission in two months..

  16. A Case of Relapsing Polyarthritis Associated With Hidradenitis Suppurativa

    Directory of Open Access Journals (Sweden)

    Avinash Adiga MD

    2016-11-01

    Full Text Available Hidradenitis suppurativa (HS is a chronic, inflammatory follicular skin disease with recurrent skin nodules, sinus tracts, and scarring. We observed a case of HS associated with relapsing polyarthritis. On presentation the patient had a flare of polyarthritis with an increase in the number and size of pustular nodules. He has had similar episodes 1 to 2 times yearly subsiding with antibiotic treatment. Radiographs revealed erosions and demineralization. Symptoms improved following institution of anti-inflammatory and antibiotic therapy. HS is associated with several inflammatory conditions, and dysregulation in innate immunity may play an important role in etiopathogenesis. Spondyloarthritis/sacroiliitis is the most common joint manifestation in HS and mechanism(s underlying arthropathy is unknown. Treatment of arthritis in HS is anecdotal.

  17. Pyoderma Vegetans: A Case Report in a Child Suspected to Primary Immunodeficiency and Review of the Literature

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    Mahboubeh Mansouri

    2015-07-01

    Full Text Available Pyoderma vegetans (PV is a rare inflammatory disorder characterized by vegetating pustules and plaques affecting the skin and mucosal membranes. It is believed that this entity is mostly associated with inflammatory bowel disease (IBD, chronic malnutrition, human immunodeficiency virus (HIV, malignancies, and other immunocompromised states. Pyoderma vegetans occurs more commonly in young and middle-aged adults. There is no sex predilection for this entity. The lesions could heal spontaneously, but usually recur and become chronic. Our patient was an 11-year-old girl suspected to have primary combined immunodeficiency complicated by chronic recurrent vegetating pustular lesions on the face and postauricular area since one year of age. The histological features of the lesions were consistent with pyoderma vegetans. This is the first case of PV beginning from early infancy in the setting of primary immunodeficiency and in an unusual location.

  18. Eosinophilic follicular reaction induced by Demodex folliculorum mite: a different disease from eosinophilic folliculitis.

    Science.gov (United States)

    Sabater-Marco, V; Escutia-Muñoz, B; Botella-Estrada, R

    2015-06-01

    Eosinophilic folliculitis (EF) is an idiopathic dermatitis included in the spectrum of eosinophilic pustular follicular reactions. Demodex folliculorum has been implicated as contributing to the pathogenesis of human immunodeficiency virus-associated EF, but it has not been described outside this context. We present an immunocompetent 65-year-old white man with a 5-year history of recurrent pruritic erythematous and oedematous lesions on his face, neck and scalp. Histopathologically, an eosinophilic microabcess with Demodex folliculorum mite within a pilosebaceous follicle was seen, and considered the causal agent. There were also accumulations of eosinophil granules on collagen bundles, and flame figure formations in the dermis. We believe that 'eosinophilic follicular reaction' is an appropriate term to describe this case of EF induced by D. folliculorum and thus distinguish it from the idiopathic form of EF. Moreover, this case suggests that D. folliculorum can sometimes induce an eosinophilic immune reaction. © 2015 British Association of Dermatologists.

  19. Acute generalized exanthematous pustulosis provoked by furosemide

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    Andżelika Schwann-Majewska

    2015-06-01

    Full Text Available Introduction. Acute generalized exanthematous pustulosis (AGEP is a skin disease characterized by the sudden appearance of generalized pustules, accompanied by elevated body temperature and neutrophilia. Objective. Presentation of a patient with AGEP provoked by furosemide. Case report. We present a case of a 65-year-old patient diagnosed with and treated for generalized pustular eruption, with fever and changes in laboratory tests. Numerous coexisting medical conditions and a great number of frequently changed drugs (ciprofloxacin, allopurinol, folic acid, calcium carbonate, cyclophosphamide, atorvastatin, betaxolol and furosemide hindered identification of the causative factor. Conclusions. On the basis of the medical history and clinical picture, the patient was diagnosed with generalized exanthematous pustulosis induced by furosemide.

  20. Paradoxical Reaction to Golimumab: Tumor Necrosis Factor α Inhibitor Inducing Psoriasis Pustulosa

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    Marien Siqueira Soto Lopes

    2013-11-01

    Full Text Available Importance: Golimumab is a human monoclonal antibody, used for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Adverse reactions are increasing with this class of medication (tumor necrosis factor α inhibitors. Observations: The authors present a case of a female patient who presented with psoriasis pustulosa after the use of golimumab for rheumatoid arthritis. Conclusions and Relevance: Paradoxically, in this case, golimumab, which is used for psoriasis, induced the pustular form of this disease. We are observing an increasing number of patients who develop collateral effects with tumor necrosis factor α inhibitors, and the understanding of the mechanism of action and how these adverse reactions occur may contribute to avoid these sometimes severe situations.

  1. Tick Bite Alopecia: A Report and Review.

    Science.gov (United States)

    Lynch, Michael C; Milchak, Marissa A; Parnes, Herbert; Ioffreda, Michael D

    2016-11-01

    Tick bites can cause a number of local inflammatory reactions, which are often difficult to differentiate from those induced by other arthropod bites or stings. These include erythematous nodular or pustular lesions, erosive plaques, annular lesions of erythema chronicum migrans, and both scarring and nonscarring inflammatory alopecia. We report a case of nonscarring alopecia in a 21-year-old male who reported a recent history of tick bite to the scalp. The biopsy demonstrated a dense pseudolymphomatous inflammatory infiltrate with numerous eosinophils associated with hair follicle miniaturization and an elevated catagen-telogen count. Signs of external rubbing, including lichen simplex chronicus and the "hamburger sign", were also visualized and are indicative of the associated pruritus. To the authors' knowledge, this is the fifth report of nonscarring tick bite alopecia in the literature and the first in an adult patient. This text will review the classic clinical presentation, histologic findings, and proposed mechanism of tick bite alopecia.

  2. Acute generalized exanthematous pustulosis induced by hydroxychloroquine: a case with atypical clinical presentation.

    Science.gov (United States)

    Duman, Hatice; Topal, Ilteris Oguz; Kocaturk, Emek; Cure, Kubra; Mansuroglu, Ilknur

    2017-01-01

    Acute generalized exanthematous pustulosis is a rare drug-induced eruption that is characterized by acute, nonfollicular sterile pustules on an erythematous and edematous base. The most frequently implicated drugs are beta-lactam antibiotics. Hydroxychloroquine has been widely used to treat dermatologic and rheumatologic diseases and has been reported as a rare cause of acute generalized exanthematous pustulosis. A 42-year-old female presented with pustular lesions on the skin surface with erythema, facial edema, and occasional atypical target-like lesions after 21 days of treatment with 200mg/day hydroxychloroquine for rheumatoid arthritis, diagnosed one month previously. We report a case with acute generalized exanthematous pustulosis induced by hydroxychloroquine and treated with dapsone and systemic corticosteroid.

  3. Acute generalized exanthematous pustulosis induced by the essential oil of Pistacia lentiscus.

    Science.gov (United States)

    Zaraa, I; Ben Taazayet, S; Trojjet, S; El Euch, D; Chelly, I; Haouet, S; Mokni, M; Ben Osman, A

    2012-06-01

    Acute generalized exanthematous pustulosis (AGEP) is an uncommon pustular eruption characterized by small nonfollicular pustules on an erythematous background, sometimes associated with fever and neutrophilia. Over 90% of cases are drug-induced; however, it can be caused in rare cases by other agents. We report two cases of AGEP secondary to ingestion of Pistacia lentiscus essential oil, the first two such cases to our knowledge. The cutaneous morphology, disease course and histological findings were consistent with a definite diagnosis of AGEP, based on the criteria of the EuroSCAR study group. These two cases highlight the need to consider herbal extracts as a potential rare cause of AGEP and to ensure the safety of herbal medicines. © The Author(s). CED © 2012 British Association of Dermatologists.

  4. [Sweet's syndrome and phenylbutazone-induced sialadenitis].

    Science.gov (United States)

    Levang, J; Muller, P; Girardin, P; Humbert, P

    2008-04-01

    Phenylbutazone frequently induces a range of potentially dangerous adverse reactions. We report a case of Sweet's syndrome with sialadenitis induced by phenylbutazone. A 54-year-old woman presented lumbar pains treated with phenylbutazone for three days. Six days later, she exhibited inflammation of the submaxillary and parotid salivary glands, followed by an erythematous, oedematous, pustular and febrile eruption, with failure of antibiotic therapy. Laboratory data showed leukocytosis and neutrophilia, anaemia, an elevated platelet count and liver dysfunction. The infectious and autoimmune tests were negative. The skin biopsy confirmed Sweet's syndrome. Clinical and biological abnormalities resolved on administration of systemic steroids. Phenylbutazone-induced sialadenitis is rare and presents unrecognized adverse effects that may be associated with a systemic reaction. In the present case report, Sweet's syndrome met the criteria for drug-induced Sweet's syndrome. There appears to have been a systemic reaction caused by a hypersensitivity mechanism, in the same way as sialadenitis.

  5. [What's new in dermatology?].

    Science.gov (United States)

    Ingber, Arieh

    2012-10-01

    Skin diseases have been the focus of many innovations in the last decade. These innovations are mainly in the classification of skin diseases (primarily due to the dramatic development of research into the genetics of skin diseases, but not only because of this element), a new understanding of the processes underlying various diseases, improvements in diagnosis and innovations in drug treatment. In the current issue of "Harefuah", we review some advances in the field of skin diseases discovered in recent years. We review psoriasis as a multi-system disease, describe new insights into polyarteritis nodosa, parapsoriasis, autoinflammatory syndromes, and pustular psoriasis of pregnancy (impetigo herpetiformis). We also describe the new immunotherapy for metastatic melanoma. Dermatology aLso has new technological developments, especially the in vivo reflected mode confocal laser microscopy. We describe in detail the use of this technique in dermatology.

  6. Acute Generalized Exanthematous Pustulosis (AGEP Induced by Cetirizine in a Child A Case Report

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    Gunseli Pancar

    2014-12-01

    Full Text Available Acute Generalized Exanthematous Pustulosis (AGEP, is a rare cutaneous rash characterized by widespread sterile non-follicular pustules. AGEP is a rare disease in childhood and it is often due to drugs. Antibiotics, sulphanamides and antipyretic-analgesics are the main reasons of this drug reaction . Cetirizine is a second generation antihistamine is often used in the treatment of angioedema, atopic dermatitis and urticaria in children. Cetirizine induced AGEP was not reported in the literature. In this case a twelve year old child was admitted with urticarial plaques located on her trunk. She developed maculopapular lesions and pustular eruption with Cetirizine (once a day treatment. Cetirizine was stopped and the nonfollicular pustules cleared with a desquamation. The result of the oral challenge test was positive. We present this rare case to show that the antihistamines (cetirizine may cause AGEP in childhood.

  7. [Rosacea].

    Science.gov (United States)

    Grosshans, E

    1988-12-17

    Rosacea should no longer be considered a follicular skin disease. It is a vascular disease of the face characterized by a significant evolution towards local complications such as telangiectasias, papular and aseptic pustular lesions, lupoid granulomas, chronic facial oedema and seboglandular hyperplasia. The basic abnormality seems to be a microcirculatory disturbance of the function of the facial angular veins directly involved in the brain-cooling vascular mechanism. The first clinic hallmark of this dysfunction is the occurrence of flushing, which may be spontaneous or induced by alcohol, intake of hot food, emotional stress and sudden variations in temperature. Tetracycline, metronidazole and isotretinoin are very useful for therapy but they only influence the cutaneous and ocular complications and do not act upon the basic vascular trouble. Current therapeutic research is directed towards drugs having an alpha-sympathomimetic activity and inhibiting the endogenous opioid mediators of flushing such as naloxone or clonidine.

  8. Diagnósticos diferenciales de la histiocitosis a células de Langerhans The differential diagnostics of Langerhans cell histiocytosis

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    C. N. Chirino

    2007-06-01

    Full Text Available La histiocitosis a células de Langerhans (HCL debe diferenciarse de las siguientes entidades: eritema tóxico neonatorum (ETN, dermatitis seborreica (DS, foliculitis pustulosa eosinofílica (FPE, incontinencia pigmenti (IP, mastocitosis/urticaria pigmentosa (M/UP, acrodermatitis enteropática (ADE, síndrome de Wiskott-Aldrich (WAS, acropustulosis infantil (API. Además se deben considerar la enfermedad de Rosai- Dorfman (ERD, xantomas diseminados, melanosis pustulosa neonatal (MPN, candidiasis congénita, listeriosis neonatal, herpes simple perinatal y la varicela neonatal. Debido a que los métodos auxiliares de laboratorio no siempre están disponibles o los resultados laboratoriales algunas veces son extemporáneos, y puesto que el médico práctico a menudo necesita tomar decisiones precozmente, es que la epidemiología resulta útil, pues brinda el marco adecuado para ordenar y jerarquizar las sospechas diagnósticas frente a un caso concreto, con un paciente determinado, en un momento específico.The differential diagnostics of Langerhans cell histiocytosis should include the following disorders: erythema toxicum neonatorum, seborrheic dermatitis, eosinophilic pustular folliculitis, incontinentia pigmenti, mastocytosis / urticaria pigmentosa, acrodermatitis enteropathica, Wiskott-Aldrich syndrome, infantile acropustulosis, Rosai- Dorfman disease, xanthoma disseminatum, neonatal pustular melanosis, congenital candidiasis, perinatal listeriosis, perinatal herpes simplex, neonatal varicella. Since the auxiliary methods of lab are not always available, or lab results are sometimes extemporaneous, the physicians often needs to make quick decisions. The epidemiology is useful because it offers the appropriate mark to prioritize the diagnostic in specific cases

  9. Successful treatment of mild to moderate acne vulgaris with Dr Michaels® (also branded as Zitinex®) topical products family: a clinical trial.

    Science.gov (United States)

    Wollina, U; Tirant, M; Bayer, P; Coburn, M; Anderson, P; Donnelly, B; Kennedy, T; Gaibor, J; Arora, M; Clews, L; Walmsley, S; Hercogovấ, J; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Novotny, F; Roccia, M G; Maximov, G K; França, K; Lotti, T

    2016-01-01

    Acne vulgaris is an epidemic inflammatory skin disease of multi-factorial origin, frequently seen in adolescents and often persisting or occurring through to adulthood. Acne vulgaris is a nearly universal skin disease afflicting 79-95% of the adolescent population in westernized societies and is a significant cause of psychological morbidity in affected patients. Despite the various treatment options available for acne, there is still a need for a safe and effective option. The aim of the study was to investigate the efficacy and tolerability of Dr Michaels® (Zitinex®) product family in the treatment of papulo-pustular acne. 25 patients (17 female/8 male), aged 15-22, with a mild to moderate papulo-pustular acne, localized on the face and on the trunk, were included in this study. None of the patients had used any other kind of treatment in the 3 months prior to commencing this study. All of the patients were treated with Dr Michaels® (Zitinex®) facial exfoliating cleanser, activator formula, a cream, PSC 200 and PSC 900 oral supplements. Application time of Dr Michaels® (Zitinex®) products was 12 weeks. The treatment was been evaluated clinically at 0, 4, 8 and 12 weeks. All of the patients showed an improvement in all parameters of their acne (comedones, papules, pustules, hyperpigmentation and scars). The acne lesions and erythema had mostly resolved. The hyperpigmentation and pitted scarring had significantly reduced also, with the skin appearing smoother. The treatment was well tolerated and no side effects have been described. Our study demonstrates that the Dr Michaels® (Zitinex®) facial exfoliating cleanser, activator formula, cream and oral supplements PSC 200 and PSC 900 are an effective therapeutic option for the treatment of moderately severe acne vulgaris. Moreover, it highlights the safety profile of the Dr Michaels® (Zitinex®) product family in a case of acne compared to traditional first-line treatments.

  10. Acneiform Eruption and Other Dermatologic Side Effects Induced by Targeted Cancer Therapy: A Retrospective Analysis

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    Kurtuluş Didem Yazganoğlu

    2012-06-01

    Full Text Available Background and Design: Epidermal growth factor receptor (EGFR inhibitors may cause different adverse cutaneous reactions including acneiform (pustular, papulopustular eruption. Rarely, other specific targeted cancer therapy agents may cause similar pustular eruptions. The aim of this study was to evaluate the adverse skin reactions, mainly acneiform eruptions caused by these chemotherapeutic agents. Material and Methods: We retrospectively analyzed the data of 23 patients who developed acneiform eruption due to chemotherapeutic agents between May 2007 and April 2011. The drugs causing acneiform eruption, clinical features of eruption, other associated dermatologic adverse reactions and the treatment modalities used for the acneiform reaction were noted. Results: EGFR inhibitors such as erlotinib and cetuximab were the main drugs causing acneiform eruption in 21 patients. Everolimus and bevacizumab in combination with irinotecan were responsible in two patients. The eruption occurred on the face in all patients. The trunk, neck and the scalp were other affected body parts in some patients. The periorbital area on the face was generally spared. Xerosis and paronychia were the main associated adverse cutaneous reactions. Trichomegaly was another finding in two patients. The patients, who could have been followed, responded to topical or systemic antibiotics, or some medications for acne vulgaris/rosacea. Chemotherapy could be continued in all patients. Conclusion: Dermatologists need to know the specific eruptions occurring with chemotherapy drugs, especially EGFR inhibitors in order to develop the best approach without discontinuation of cancer therapy. Acneiform eruptions due to chemotherapeutics are most commonly seen on the face sparing periorbital area. Other reactions including mainly xerosis, paronychia and trichomegaly can also occur.

  11. Características clínicas y epidemiológicas de la escabiosis en tres consultorios del médico de la familia

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    Ana I. Chacón Cabrera

    1998-08-01

    Full Text Available Se estudiaron 67 pacientes con escabiosis de los consultorios 12,21 y 26 del Policlínico «Héroes del Corinthya» y se encontró una incidencia del 5,13 % con una frecuencia esperada de 22 casos anuales por consultorio. La enfermedad fue más frecuente entre las mujeres de 45 a 54 años y entre los obreros de nivel medio de escolaridad. Se identificaron lesiones elementales poco comunes y localizaciones no habituales de las lesiones para esta dermatosis. El mayor número de casos mejoró entre los 8 y los 14 días de implantadas las medidas de control para la enfermedad67 patients affected by scabies who were cared for by family physicians’ consulting rooms No. 12, 21 and 26 of «Héroes del Corinthia» polyclinics were examined where 5.13 % of incidence and an expected frequency of 22 cases per year per consulting room were found. This disease was more frequently suffered by women aged 45 to 54 years and by medium educational level workers. Uncommon basic lesions and rare lesion locations for this kind of dermatosis were detected. The majority of cases recovered 8 to 14 days after adequate disease control measures being implemented

  12. Eritema anular eosinofílico en un adulto Eosinophilic anular erythema in an adult.

    Science.gov (United States)

    Lobo, Marta Aguado; Gonzalo, Elena Sierra; Jiménez-Reyes, José

    2017-10-15

    Eosinophilic annular erythema (EAE) is an uncommon eosinophilic dermatosis. Clinically it is characterized by recurrent episodes of annular or figurative plaques. The histopathological study shows a perivascular inflammatory infiltrate in the superficial and deep dermis, composed of lymphocytes and eosinophils. It was originally described in children. We report an adult woman who presented with recurrent erythematous annular plaques on the trunk and extremities. A biopsy showed a mainly perivascular lymphocytic infiltrate with numerous eosinophils in the dermis. Laboratory examinations revealed subclinical hypothyroidism. The lesions resolved with topical corticosteroid spontaneously after 3 months.El eritema anular eosinofílico (EAE) es una dermatosis eosinofílica poco frecuente. Clínicamente se caracteriza por episodios recurrentes de placas anulares o figuradas.El estudio histopatológico muestra un infiltrado inflamatorio en dermis superficial y profunda, de localización perivascular y compuesto por linfocitos y eosinófilos. Se describió originariamente en niños. Presentamos una mujer adulta con episodios recurrentes de placas anulares o figuradas en el tronco y extremidades. La biopsia mostró un infiltrado linfocítico perivascular con numerosos eosinófilos en la dermis. La analítica reveló la presencia de hipotiroidismo subclínico. Las lesiones se resolvieron después de tres meses de tratamiento con una crema de corticoesteriodes.

  13. Dermatitis atópica psoriasiforme en edad pediátrica

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    Yordania Velázquez Ávila

    2014-08-01

    Full Text Available La dermatitis atópica es una dermatosis reaccional crónica recidivante, con afectación del sistema inmune en individuos predispuestos genéticamente. Es multifactorial y por lo general se manifiesta en la infancia. En ocasiones se presenta con características semejantes a otras entidades dermatológicas. Al servicio de dermatología del hospital pediátrico Mártires de Las Tunas acudió una paciente en edad pre-escolar, con manifestaciones clínicas atípicas que simulaba otras dermatosis eritematoescamosas; la mamá refería desconocer si existían antecedentes familiares de atopía; con tendencia a la cronicidad y refractaria al uso de corticoesteroides tópicos. Se realizó el estudio histopatológico, se observaron elementos compatibles con una dermatitis atópica variedad psoriasiforme. En este caso la dermatitis atópica se presentó de forma atípica, siendo ésta la motivación de su presentación. Para el tratamiento se utilizó inmunoterapia, se logró mejoría clínica de las lesiones

  14. Dermatologic conditions in skin of color: part II. Disorders occurring predominately in skin of color.

    Science.gov (United States)

    Kundu, Roopal V; Patterson, Stavonnie

    2013-06-15

    Several skin conditions are more common in persons with skin of color, including dermatosis papulosa nigra, pseudofolliculitis barbae, acne keloidalis nuchae, and keloids. Dermatosis papulosa nigra is a common benign condition characterized by skin lesions that do not require treatment, although several options are available for removal to address cosmetic concerns. Pseudofolliculitis barbae occurs as a result of hair removal. Altering shaving techniques helps prevent lesions from recurring. In acne keloidalis nuchae, keloidal lesions are found on the occipital scalp and posterior neck. Early treatment with steroids, antibiotics, and retinoids prevents progression. A key part of the management of keloids is prevention. First-line medical therapy includes intralesional steroid injections. The distinct structure of the hair follicle in blacks results in hair care practices that can lead to common scalp disorders. For example, chemical relaxers decrease the strength of hair and may cause breakage. Better patient education, with early diagnosis and treatment, often leads to better outcomes. © 2013 American Academy of Family Physicians.

  15. Elastose perfurante serpiginosa em portadora da síndrome de Down Elastosis perforans serpiginosa in a patient with Down's syndrome

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    Ana Carolina Figueiredo Pereira

    2010-10-01

    Full Text Available A elastose perfurante serpiginosa é dermatose perfurante primária incomum, frequentemente associada a determinadas doenças genéticas e caracterizada por eliminação transepidérmica de fibras elásticas. Relata-se um caso raro dessa dermatose em paciente feminina de 19 anos, portadora da síndrome de Down, que apresentava pápulas eritematoceratóticas em arranjo arciforme, localizadas no antebraço e joelho direitos, assintomáticas, com cinco anos de evolução. Após confirmação histopatológica, foi iniciado tratamento com crioterapia, ocorrendo remissão parcial das lesões.Elastosis perforans serpiginosa is a rare, primary perforating dermatosis, frequently associated with certain genetic diseases and characterized by the transepidermal extrusion of elastic fibers. The present case report describes this dermatosis in a 19-year old female patient with Down's syndrome, who presented with asymptomatic erythematous, keratotic papules in an arciform pattern, located on her right forearm and knee, which had been present for five years. Following histopathological confirmation, treatment with cryotherapy was initiated, resulting in partial remission of the lesions.

  16. Miasis cutánea forunculoide: un caso diagnosticado en Cuba Furunculoid cutaneous myasis: a case diagnosed in Cuba

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    Kárel Durán Marrero

    2006-09-01

    Full Text Available En este trabajo se presenta un caso de miasis cutánea forunculoide diagnosticado en el Servicio de Dermatología del Hospital Universitario “Comandante Faustino Pérez” de la ciudad de Matanzas. La paciente adquirió esta dermatosis en Costa Rica, pero desarrolló el cuadro clínico típico en nuestro país, donde recibió tratamiento médico. Se describen las características de las miasis cutáneas y de los agentes que las producen, así como su distribución geográfica y las opciones terapéuticas ante estos casos. Este trabajo tiene especial interés para los médicos internacionalistas que brindan sus servicios en países donde estas enfermedades son frecuentes.A case of furunculoid cutaneous myasis diagnosed at the Dermatology Service of "Comandante Faustino Pérez" University Hospital , in the city of Matanzas , is reported. The patient acquired this dermatosis in Costa Rica , but she developed the typical clinical picture in our country, where she received medical treatment. The characteristics of cutaneous myasis and of the agents producing it are described, as well as its geographical distribution and the therapeutic options to treat these cases. This paper has a special interest for the internationalist doctors that work in countries where these diseases are common.

  17. Lepra en la infancia: Desafío diagnóstico Leprosy in childhood: Diagnostic challenge

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    AE Táquez

    2011-12-01

    Full Text Available La lepra en la infancia cursa con una diversidad de manifestaciones clínicas e histopatológicas, que hacen necesario un minucioso examen cutáneo en todo niño, que presente lesiones dermatológicas sugestivas y una fuente infecciosa sospechosa. Para un oportuno diagnóstico es indispensable que el médico tenga siempre presente la enfermedad, así como destreza al realizar el examen clínico, ya que muchas lesiones cutáneas suelen ser asintomáticas y con frecuencia simulan otros cuadros dermatológicos. Presentamos tres casos de pacientes erróneamente diagnosticados, tratados por otras dermatosis y quienes finalmente estaban afectados de lepra.Leprosy in childhood course with a diversity of clinical and histopathological signs that make necessary a detailed cutaneous inspection in every child that presents suggestive dermatological lesions, have had a suspected infectious contact. For an appropriate diagnosis, is very important to keep in mind the disease, as well as medical clinical skill because many skin and nerve lesions can be asymptomatic and frequently look like other dermatological pathology. The authors report three cases of children misdiagnosed and treated for other dermatosis and whom finally were found leprosy´s patients.

  18. As principais alterações dermatológicas em pacientes obesos Major dermatological changes in obese patients

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    Rosimeri da Silva Castanho Mendonça

    2011-03-01

    Full Text Available INTRODUÇÃO: A obesidade é considerada grave doença crônica que vem atingindo proporções mundiais gerando transtornos sérios para a saúde pública. No Brasil, a prevalência desta doença denota aumento progressivo em relação ao número de pessoas com sobrepeso e/ou obesidade. Apesar disso, as manifestações dermatológicas da obesidade têm sido pouco estudadas. OBJETIVO: Abordar as dermatoses que mais acometem pacientes obesos e seu tratamento, principalmente na aplicação adequada da fisioterapia dermatofuncional. MÉTODO: Revisão da literatura, entre 2000 e 2010, de artigos indexados nas bases Medline/Pubmed, Scielo e Lilacs, livros e monografias das bibliotecas da Universidade de Fortaleza e Universidade Federal do Ceará, Fortaleza, CE, Brasil, cruzando os descritores obesidade, dermatose e fisioterapia. Foram reconhecidas como mais importantes as seguintes situações patológicas: estrias, celulite, acanthosis nigricans, acrocórdons, flacidez, úlcera e impetigo. Entre as formas de tratamento deuse destaque à atuação da fisioterapia dermatofuncional. CONCLUSÃO: O tratamento das dermatoses por meio da fisioterapia dermatofuncional é possível podendo trazer consigo resultados que satisfaçam a expectativa dos pacientes e proporcionando-lhes melhor qualidade de vida.INTRODUCTION: Obesity is a serious chronic disease that has reached global proportions causing problems to public health. In Brazil, the prevalence of this disease shows a progressive increase in the number of people with overweight or obesity. Nevertheless, the skin manifestations have not been well studied. OBJECTIVE: To analyse the dermatosis most affecting obese patients and its treatment, particularly in proper application of dermatological therapy. METHOD: Was made a literature review between 2000 and 2010 of articles published in Medline/ PubMed, SciELO and Lilacs, books and monographs of the libraries of the University of Fortaleza and the Federal

  19. Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering✩

    Science.gov (United States)

    Yoshida, Kenji; Ishii, Ken; Shimizu, Atsushi; Yokouchi, Mariko; Amagai, Masayuki; Shiraishi, Ken; Shirakata, Yuji; Stanley, John R.; Ishiko, Akira

    2017-01-01

    Background Pemphigus foliaceus (PF) is an autoimmune blistering disease caused by autoantibodies (Abs) against desmoglein 1 (Dsg1). PF sera contain polyclonal Abs which are heterogeneous mixture of both pathogenic and non-pathogenic Abs, as shown by isolation of monoclonal Abs (mAbs). Objective To investigate how pathogenic and non-pathogenic anti-Dsg1 Abs contribute to blister formation in PF. Methods Using organ-cultured human skin, we compared the effect of a single pathogenic anti-Dsg1 IgG mAb, a single non-pathogenic anti-Dsg1 IgG mAb, and their mixture on blister formation as analyzed by histology, subcellular localization of IgG deposits and desmosomal proteins by confocal microscopy, and desmosomal structure by electron microscopy. In addition, we measured keratinocyte adhesion by an in vitro dissociation assay. Results 24 h after injection, a single pathogenic anti-Dsg1 IgG caused a subcorneal blister with IgG and Dsg1 localized linearly on the cell surface of keratinocytes. A single non-pathogenic anti-Dsg1 IgG bound linearly on the keratinocytes but did not induce blisters. A pathogenic and a non-pathogenic IgG mAb injected together caused an aberrant granular pattern of IgG and Dsg1 in the lower epidermis with blister formation in the superficial epidermis. Electron microscopy demonstrated that the mixture of mAbs shortened desmosomal lengths more than a single mAb in the basal and spinous layers. Furthermore, although Dsg1 clustering required both cross-linking of Dsg1 molecules by the non-pathogenic IgG plus a pathogenic antibody, the latter could be in the form of a monovalent single chain variable fragment, suggesting that loss of trans-interaction of Dsg1 is required for clustering. Finally, a p38MAPK inhibitor blocked Dsg1 clustering. When pathogenic strength was measured by the dissociation assay, a mixture of pathogenic and non-pathogenic IgG mAbs disrupted keratinocyte adhesion more than a single pathogenic mAb. This pathogenic effect was only

  20. Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering.

    Science.gov (United States)

    Yoshida, Kenji; Ishii, Ken; Shimizu, Atsushi; Yokouchi, Mariko; Amagai, Masayuki; Shiraishi, Ken; Shirakata, Yuji; Stanley, John R; Ishiko, Akira

    2017-03-01

    Pemphigus foliaceus (PF) is an autoimmune blistering disease caused by autoantibodies (Abs) against desmoglein 1 (Dsg1). PF sera contain polyclonal Abs which are heterogeneous mixture of both pathogenic and non-pathogenic Abs, as shown by isolation of monoclonal Abs (mAbs). To investigate how pathogenic and non-pathogenic anti-Dsg1 Abs contribute to blister formation in PF. Using organ-cultured human skin, we compared the effect of a single pathogenic anti-Dsg1 IgG mAb, a single non-pathogenic anti-Dsg1 IgG mAb, and their mixture on blister formation as analyzed by histology, subcellular localization of IgG deposits and desmosomal proteins by confocal microscopy, and desmosomal structure by electron microscopy. In addition, we measured keratinocyte adhesion by an in vitro dissociation assay. 24h after injection, a single pathogenic anti-Dsg1 IgG caused a subcorneal blister with IgG and Dsg1 localized linearly on the cell surface of keratinocytes. A single non-pathogenic anti-Dsg1 IgG bound linearly on the keratinocytes but did not induce blisters. A pathogenic and a non-pathogenic IgG mAb injected together caused an aberrant granular pattern of IgG and Dsg1 in the lower epidermis with blister formation in the superficial epidermis. Electron microscopy demonstrated that the mixture of mAbs shortened desmosomal lengths more than a single mAb in the basal and spinous layers. Furthermore, although Dsg1 clustering required both cross-linking of Dsg1 molecules by the non-pathogenic IgG plus a pathogenic antibody, the latter could be in the form of a monovalent single chain variable fragment, suggesting that loss of trans-interaction of Dsg1 is required for clustering. Finally, a p38MAPK inhibitor blocked Dsg1 clustering. When pathogenic strength was measured by the dissociation assay, a mixture of pathogenic and non-pathogenic IgG mAbs disrupted keratinocyte adhesion more than a single pathogenic mAb. This pathogenic effect was only partially suppressed by the p38MAPK

  1. Criptococosis cutánea primaria en paciente inmunocompetente.

    Science.gov (United States)

    Vázquez-Osorio, Igor; García-Rodiño, Sara; Rodríguez-Rodríguez, Marta; Labandeira, Javier; Suárez-Peñaranda, José Manuel; Sánchez-Aguilar, MDolores; Vázquez-Veiga, Hugo

    2016-05-15

    La criptococosis cutánea es una micosis propia de pacientes inmunodeprimidos, sobre todo aquellos con infección por el virusde la inmunodeficiencia humana (VIH). Sin embargo, existen casos infrecuentes de criptococosis cutánea en pacientes inmunocompetentes, que suelen simular otras dermatosis, lo que retrasa su diagnóstico y tratamiento. Presentamos el caso de un varón pluripatológico de 79 años, con úlceras dolorosas en dorso de mano derecha que no respondían a tratamientos tópicos. A través del estudio histopatológico y micológico se alcanzó el diagnóstico de criptococosis cutánea primaria, lográndose la remisión de las lesiones tras 6 meses de tratamiento con fluconazol.

  2. Papular acantholytic dyskeratosis localized to the perineal and perianal area in a young male

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    Shyam B Verma

    2013-01-01

    Full Text Available A case of Papular acantholytic dermatosis restricted to the perianal area is being reported in a 26 year old male without involvement of the genitalia, groin and upper thighs for the first time in English literature. The patient presented with long standing grayish white confluent papules with eroded areas in the perianal region which were asymptomatic for a long time before the area got macerated. He did not respond to many weeks of topical steroids but is now showing improvement with topical tacrolimus ointment 0.1% applied twice daily. This entity appears to be very uncommon and also underreported. It is also suggested that this entity be included in the long list of non venereal anogenital lesions as it may mimic perianal warts or molluscum contagiosum.

  3. Impetigo update: new challenges in the era of methicillin resistance.

    Science.gov (United States)

    Geria, Aanand N; Schwartz, Robert A

    2010-02-01

    Impetigo is a bacterial infection of the superficial epidermis most commonly seen in infants and children. It is clinically characterized by crusted erosions or ulcers that may arise as a primary infection in which bacterial invasion occurs through minor breaks in the cutaneous surface or a secondary infection of a preexisting dermatosis or infestation. Impetigo occurs in 2 forms: bullous and nonbullous. Staphylococcus aureus currently is the most common overall cause of impetigo, but Streptococcus pyogenes remains an important cause in developing nations. Community-acquired methicillin-resistant S aureus (CA-MRSA) poses a challenge because of its enhanced virulence and increasing prevalence in children. For limited uncomplicated impetigo, either topical mupirocin or fusidic acid is as effective if not more effective than systemic antibiotics. For extensive or complicated impetigo, systemic antibiotics may be warranted, but beta-lactam antibiotics should be avoided if methicillin-resistant S aureus (MRSA) is suspected.

  4. Confluent and reticulated Papillomatosis of Gougerot and Carteaud - presentation in adolescence

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    Joana Leite

    2015-12-01

    Full Text Available Introduction: Confluent and reticulated papillomatosis (CRP of Gougerot and Carteaud is a rare dermatosis characterized by brownish papules with fine scaling, forming confluent plaques in the center and reticulated at the periphery. It is preferentially located in the central region of the trunk, armpits and neck. Case Report: A 13 year-old overweight female adolescent was admitted to Dermatology outpatient clinic for asymptomatic brownish skin lesions. At physical examination she presented brown plaques spread out on the breast, neck and armpits. Laboratory studies were normal and skin biopsy supported the hypothesis of CRP. She was initially treated with minocycline, suspended after completing the recommended treatment time. Then, the lesions began to return and oral isotretinoin was started with lesions resolution. Discussion: The CRP is a rare pathology that, by their usual adolescent onset and predominance in females, may have physical and psychological implications on self-image. The etiology is probably multifactorial, so there are several therapeutic options.

  5. Sensitization study of dogs with atopic dermatitis in the central region of Rio Grande do Sul

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    D.T. Pereira

    2015-12-01

    Full Text Available Canine atopic dermatitis (CAD is a common dermatosis, defined as a genetic-related disease which predisposes to skin inflammation and pruritus, associated to a IgE-specific response in most of cases. Clinical diagnosis may be later complemented by skin allergy and/or serological tests. The aim of these tests is to identify possible allergens in order to enable the clinicians to select candidate antigens for allergen specific immunotherapy. In the present study 58 CAD positive animals were tested. All were submitted to the intradermal test (IDT and screened for the presence of antibodies against different antigens using ELISA. The obtained results show a high prevalence of sensitization among the tested dogs to house dust mites and to pollen ofC. dactylon. With this work it was possible to identify the main allergens involved in immunological response of dogs with CAD living in central area of Rio Grande do Sul.

  6. Cold Injury and Perniosis (Chilblain

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    Tuba Tulay Koca

    2015-12-01

    Full Text Available Perniosis (chilblain is inflammatory cutaneous lesions located on acral surfaces (fingers, toes, nose, aurikula which present in association with cold exposure. They can appear as an idiopathic (primary dermatosis or with an underlying autoimmune disease (secondary. The primary or idiopathic form is not associated with an underlying disease and is clinically indistinguishable from the secondary form. The secondary form is associated with an underlying condition such as connective tissue disease, monoclonal gammopathy, cryoglobulinemia, or chronic myelomonocytic leukemia. Histopathology cannot accurately help distinguish the primary from secondary forms of chilblains. This review aims to raise the awareness of perniosis to avoid excessive investigation and anxiety and to help patients with only appropriate simple advice and treatment. [Archives Medical Review Journal 2015; 24(4.000: 463-471

  7. A case of feline paraneoplastic alopecia with secondary Malassezia-associated dermatitis.

    Science.gov (United States)

    Godfrey, D R

    1998-08-01

    A 13-year-old neutered female domestic shorthaired cat had progressive ventral abdominal alopecia attributed initially to hyperthyroidism. Corrective treatment by unilateral thyroidectomy did not, however, resolve the dermatosis and the alopecia progressed to involve the whole ventral trunk, the lower limbs and the head. Pruritus of the lower limbs was a prominent feature and was associated with the finding of Malassezia on cytology; Malassezia-associated dermatitis was diagnosed. Resolution of pruritus was seen after treatment with oral ketoconazole and a cleansing shampoo to eliminate the yeast, but severe polyphagia, small intestinal diarrhoea and polydipsia developed subsequently and the cat was euthanased. Necropsy revealed an exocrine pancreatic adenocarcinoma with hepatic metastases. The pancreatic, hepatic and dermatological lesions were found to be typical of feline paraneoplastic alopecia (FPA). Malassezia-associated dermatitis can be associated with pruritus in cats with FPA.

  8. Estudio de la patología psiquiátrica en pacientes que acuden a la consulta dermatológica

    OpenAIRE

    Pera Grasa, José Telmo

    2012-01-01

    La psicodermatología es una disciplina de transición entre la dermatología y la psiquiatría, que se ocupa del estudio de la influencia del estrés psicosocial en la reagudización o cronificación de las enfermedades dermatológicas, así como de analizar también la comorbilidad psiquiátrica existente en numerosas dermatosis y el papel de los tratamientos coadyuvantes, bien sean de tipo psicofarmacológico, psicoterapéutico o social. Material y métodos: Se realizó un estudio transversal en 300 p...

  9. Erythema Ab igne after footbath with Chinese herbal remedies

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    Jeng-Feng Chen

    2011-01-01

    Full Text Available Erythema ab igne (EAI is a reticulated, telangiectatic, and hyperpigmented skin eruption resulting from chronic exposure to long-term moderate heat. The incidence has decreased substantially today because of the advent of modern central heating systems. Recently, we encountered a patient who developed EAI after 2 weeks of footbaths with Chinese herbal remedies, which she used to treat her acute ankle sprain. Alternative Chinese medicine, such as herbal footbath, is a prevalent medical practice to treat acute pains as well as many chronic musculoskeletal ailments among Chinese and Asian populations. It has also become increasingly popular in Western countries in the past decade. Herein, we would like to report an uncommon case of iatrogenic EAI caused by footbath and raise the attention of clinicians to such rare, potentially malignant-transforming, dermatosis.

  10. Kaposi’s Varicelliform Eruption During Treatment of Atopic Dermatitis with Pimecrolimus Cream

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    Filiz Canpolat

    2010-03-01

    Full Text Available Kaposi’s varicelliform eruption is a widespread viral infection frequently caused by herpes simplex virus types 1 and 2, and less frequently Coxsackie A-16 and vaccinia virus superimposed on a pre-existing dermatosis. It is often associated with atopic dermatitis. The topical immunomodulator pimecrolimus have proven effective in managing atopic dermatitis. Reported adverse effects are infrequent; however, cutaneous infections are potential complications of its application. Kaposi’s varicelliform eruption is the most important problem in treating patients with atopic dermatitis with pimecrolimus. Even though the causative effect of this topical immunomodulator remains unclear, patients should be thought to recognise herpes simplex virus infection and stop application to prevent the spreading of the infection. Herein we report a child with atopic dermatitis who developed Kaposi’s varicelliform eruption during treatment with pimecrolimus because of its rare occurence

  11. Recalcitrant granuloma faciale with 14-year follow-up

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    Keiko Shiba

    2017-04-01

    Full Text Available Granuloma faciale (GF is an uncommon inflammatory dermatosis that is characterized by one or several asymptomatic brown red nodules or plaques usually occurring on the face. GF is known to be extremely resistant to treatment. Various treatments have been attempted, including topical or intralesional or systemic corticosteroids, dapsone, antimalarials, colchicine, topical tacrolimus, and topical psoralen; however, none of these have been found to be reliably efficacious. We tried numerous combinations and rotations of therapeutic modalities for GF over a long time. We described a case of GF in which the eruptions were carefully observed over the course of 14 years before finally resolving. Our experience suggests that continuous and careful follow-up, and trials of combinations and rotations of therapeutic modalities are essential for treating GF.

  12. An Update on Therapeutic Management of Canine Demodicosis

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    S. K. Singh

    2011-02-01

    Full Text Available Canine demodicosis is a common noncontagious parasitic dermatosis caused by different spp of Demodex mites including Demodex canis, Demodex injai and D. cornei. Generalized demodicosis can be one of the most frustrating skin diseases, one will ever treat. Conventional and newer miticidal therapies are available to veterinarian to treat this frustrating skin disease. All recognized Demodex mites in dogs appear to respond similarly to mite targeted therapy. Treatment for canine demodicosis includes amitraz, ivermectin, milbemicin oxime, moxidectin, and doramectin. The use of any glucocorticoid-containing products is contraindicated and could favour disease generalization. Conventional treatments will often appear to work however, but it relies heavily on a highly toxic method of treatment. Using natural remedies for mange, on the other hand, can enhance the dog’s immune system, so that the body can fight off the mange mite infection by itself. [Veterinary World 2011; 4(1.000: 41-44

  13. Lichen planus and other lichenoid dermatoses: Kids are not just little people.

    Science.gov (United States)

    Payette, Michael J; Weston, Gillian; Humphrey, Stephen; Yu, JiaDe; Holland, Kristen E

    2015-01-01

    Lichenoid dermatoses, a group of inflammatory skin conditions with characteristic clinical and histopathologic findings, range from common to rare. Classic lichen planus typically presents as pruritic, polygonal, violaceous flat-topped papules and plaques; many variants in morphology and location also exist. Other lichenoid dermatoses share similar clinical presentations and histopathologic findings. These include lichenoid drug eruption, lichen planus-like keratosis, lichen striatus, lichen nitidus, and keratosis lichenoides chronica. Epidemiologic characteristics vary among each lichenoid disorder. While classic lichen planus is considered a disease of adults, other lichenoid dermatoses may be more common in younger populations. The literature contains an array of reports on the variations in presentation and successful management of lichen planus and lichenoid dermatoses among diverse populations. Familiarity with the characteristics of each lichenoid dermatosis, rare or common within each patient population, is key to accomplishing timely recognition and effective management. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. Hypertrophic lichen planus as a presenting feature of human immunodeficiency virus infection

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    Kumari Rashmi

    2009-01-01

    Full Text Available Lichen planus (LP is a chronic papulosquamous dermatosis in which both skin and mucous membranes may be involved. To date, there have been only five reports of human immunodeficiency virus (HIV-positive patients with hypertrophic LP. In the present report, we describe a 37-year-old female who presented with widely distributed, hyperpigmented, pruritic scaly lesions involving the face, trunk, and upper and lower extremities for one month. She also had swelling of both lower legs with low grade fever for past one week. She was diagnosed to be a HIV-positive patient who had severe, widespread hypertrophic LP lesions along with acute eruptive lesions of LP. These LP lesions were a presenting feature of HIV infection in our case.

  15. Recent advances in the understanding and management of rosacea

    Science.gov (United States)

    2014-01-01

    Rosacea is a chronic relapsing inflammatory facial dermatosis. There are several known triggers but the pathogenesis remains unknown. Recent achievements in understanding this disease point to the importance of skin-environmental interactions. This includes physical and chemical factors, but also microbial factors. The impairment of the skin barrier function and the activation of the innate immune defences are major and connected pathways contributing to an ongoing inflammatory response in the affected skin. This becomes modulated by endogenous factors like neurovascular, drugs, and psychological factors. These factors offer new therapeutic targets for rosacea treatment. There is a broader range of anti-inflammatory compounds available with a favourable safety record. Only recently have persistent erythema and flushing been addressed by new drug formulations. PMID:25184040

  16. Proteasomal diseases are a new branch of autoinflammatory pathology

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    Evgeny Stanislavovich Fedorov

    2013-12-01

    Full Text Available The paper deals with a new autoinflammatory disease entity that is proteasomal diseases. The latter include three nosological entities: Nakajo–Nishimura syndrome (NNS, Japanese autoinflammatory syndrome with lipodystrophy; chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE syndrome; joint contractures, muscular atrophy, microcytic anemia, and panniculitisinduced lipodystrophy (JMP syndrome. All the three conditions are caused by mutations in one PSMB8 gene encoding the immunoproteasome subunit β5i. Unlike other autoinflammatory syndromes that are mainly IL-1-dependent, the leading component of the pathogenesis of these diseases is IL-6/γ−interferonі system hyperactivation. These diseases are characterized by childhoodonset, retarded physical development, different skin and muscular lesions, lipodystrophy, joint contractures, and hypochromic anemia, as well as elevated levels of acutephase markers; autoimmune disorders may joint in time.

  17. Efficacy of the Radiotherapy on Darier’s Disease: An Indirect Evidence

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    Ala Podgornii

    2013-01-01

    Full Text Available Darier’s disease (DD is an autosomal dominant dermatosis characterized by hyperkeratotic papules that are mainly located in the seborrheic areas and pushups, handheld wells, and nails. The disease often appears at a young age, typically by the third decade, with no sex predilection. There is currently no standard therapy and there are usually topical palliative therapies. We present the case of an affected 42-year-old woman treated with radiation therapy for early breast cancer. Before the radiotherapy, the patient showed hyperkeratotic, brownish papules extending in a linear pattern for the neck to the abdomen, especially on both breasts and inframammary area. During the radiation, she developed grade 1 to 2 dermatitis in the irradiated area. At a followup of 6 months, the patient has no skin lesions in the irradiated zone. This report suggests that the radiotherapy is not contraindicated and may indeed be effective in local control of skin lesions in DD.

  18. [Erythema ab igne in a patient with bulimia nervosa].

    Science.gov (United States)

    Beneke, Johannes; Koerner, Michael; de Zwaan, Martina

    2014-05-01

    Erythema ab igne (EAI) is a skin lesion, which is characterized by a localized netlike erythema. For the occurrence of the dermatosis a continuous or regular heat exposure and infrared radiation to a skin area is necessary. The reticulated maculae could fade after stopping the heat exposure, persist as hyperpigmentation and in single cases a malignant transformation is possible. We present a patient with bulimia nervosa (BN), who developed an EAI after consequent use of a hot-water bottle. In the context of the eating disorder the patient reported a general feeling of cold. She avoided the contact with the abdomen to prevent a stimulation of the digestion. Therefore the EAI was located predominantly on the medial thighs. After stopping the heat application the EAI faded slightly in the periphery und turned browner. © Georg Thieme Verlag KG Stuttgart · New York.

  19. Erythema ab igne in an adolescent with anorexia nervosa.

    Science.gov (United States)

    Docx, Martine K F; Simons, Annik; Ramet, José; Mertens, Luc

    2013-05-01

    A rare skin lesion, erythema ab igne (EAI) is presented, in an adolescent female with anorexia nervosa. Clinical records of this patient were compared with a pubmed search about EAI in patients with an eating disorder. The patient presented with localized, spider-like, erythematous and hyperpigmented skin lesions on the lower abdomen and on both thighs. Repetitive exposure to heating pads can induce reticular and macular hyperpigmentation with telangiectases without squamation. Strict avoidance of heat is advised, because there is no effective treatment. EAI is described in patients with an eating disorder. Facing an increased pain threshold, prolonged heat exposure to treat a general feeling of cold, can induce this dermatosis. Copyright © 2012 Wiley Periodicals, Inc.

  20. [Update on Dermatobia hominis: South American furuncular myiasis].

    Science.gov (United States)

    Clyti, E; Pages, F; Pradinaud, R

    2008-02-01

    Furuncular myiasis is an infestation of the skin caused by Dermatobia hominis larvae known as "ver macaque" in French Guyana, "berne" in Brazil, "torsalo" in Colombia, or "human botfly" in English-language literature. It has identical features in man and domestic mammals. The primary lesion consists of a boil-like inflammatory papule with a central punctum exuding a serosanguinous discharge. The respiratory sinus of the D. hominis larvae may be visible through the punctum. Myiasis secondary to D. hominis accounts for 10% of imported tropical dermatosis observed in Paris. Diagnosis of furuncular myiasis should be considered in any patient with a history of travel or residence in an endemic area. Treatment depends mainly on mechanical removal that may be facilitated by injection of lidocaine into the lesion or prior application of a 1% solution of ivermectin.

  1. Furuncular myiasis caused by Dermatobia hominis, the human botfly.

    Science.gov (United States)

    Maier, Harald; Hönigsmann, Herbert

    2004-02-01

    Myiasis is a common travel-associated dermatosis. Travelers to many parts of Central and South America are susceptible to infestation by Dermatobia hominis. Despite the common name of human botfly, D hominis infests a broad range of mammals and is a severe pest to economically important farm animals in endemic regions. The adult female does not lay the eggs on the host. Instead, the adult female infests hosts indirectly by using blood-feeding arthropods to serve as phoretic vectors to transport the eggs. We present a patient who acquired Dermatobia when bitten by a day-active mosquito during a visit to Guatemala. He had a locally painful, firm furuncular lesion with a central pore that drained serosanguineous exudates. The patient applied an occlusive ointment and recovered the larva after it emerged. In this report we discuss the life cycle of D hominis, the differential diagnosis, and therapeutic approaches.

  2. Dermatobia hominis: Small Migrants Hidden in Your Skin.

    Science.gov (United States)

    Zammarchi, Lorenzo; Viligiardi, Riccardo; Strohmeyer, Marianne; Bartoloni, Alessandro

    2014-10-01

    Myiasis is a parasitic infestation of vertebrate animal tissues due to maggots of two-winged flies (Diptera) that feed on living or necrotic tissue. Dermatobia hominis occurs widely in tropical parts of Latin America; it is the most common cause of furuncular myiasis in this region. The continuous increase in international travel has increased the possibility of observing this pathology outside endemic countries, especially in travelers returning from the tropics. If clinicians are aware of the possibility of the disease and its treatment options, this dermatosis can be easily managed. However, diagnostic delay is very common because the disease is often misdiagnosed as a bacterial skin infection. Here, we report 2 cases of furuncular myiasis caused by D. hominis in travelers returning to Italy from Latin America. Surgical and noninvasive treatment approaches are also described.

  3. [Avene-50 and Ebastine in treatment and prevention of photodermatosis].

    Science.gov (United States)

    Tsiskarishvili, N V; Dundua, M M; Tsiskarishvili, N I

    2009-02-01

    The clinical efficacy of antihistaminic preparation "Kestine" (Ebastine) in combined treatment of 50 patients suffering from photo-allergic dermatosis (15 - solar urticaria, 20 - solar erythema and 15 - solar eczema) are evaluated. Kestine in dosage of 10 mg a day was prescribed in duration of 10 days. Itch disappearance was observed in 87% of patients, reduction of itching - in 10% and in 3% of patients an itch was remain. Photo protector Avene-50 as sunburn preparation, assigned for different type of skins, has been used. This preparation fit for different demands (including prevention of both beginnings and exacerbation of photo allergic reactions) of patients. Water- and sweat-resistance of Avene-50 formula has been taken in account. Treatment caused increasing of some indices of non specific reactions (Kavetski skin test) that confirms recovery of conjunctive tissue elements' activity. Efficacy and safety of this combined method of photodermatosis treatment allow us to use it widely in dermatologic clinic.

  4. Sweet's syndrome: clinicopathological features of patients treated from 1997 to 2009 at Cassiano Antonio Moraes University Hospital - Vitoria (Espirito Santo).

    Science.gov (United States)

    Eleuterio, Itamara Assini; Tiussi, Ricardo Montibeler; Delmaestro, Delio; Diniz, Lucia Martins; Lucas, Elton Almeida

    2012-01-01

    Sweet's syndrome or acute febrile neutrophilic dermatosis is rare in Brazil. It is clinically characterized by painful erythematous nodules, papules or plaques that occur mainly on the neck and upper limbs. Its cause may be unknown (idiopathic form) or it may be associated with malignancies, usually hematologic, or drugs. The authors describe 16 cases of the syndrome. The median age was 36 years, and all patients were white and presented solid lesions, predominantly on the upper limbs and trunk. Histopathological examination of the dermis of all patients revealed predominance of moderate to intense, superficial and deep, diffuse inflammatory infiltrate, mainly consisting of polymorphonuclear neutrophils, with leukocytoclasia. It also revealed changes in the epidermis and hypodermis (neutrophilic hypodermitis), but with no signs of vasculitis in most patients, which was not considered an important finding for diagnosis. Presence of exocytosis of neutrophils was common, favoring the diagnosis of Sweet's syndrome when accompanied by diffuse interstitial neutrophilic dermatitis.

  5. Comedonal Darier's disease: A case report

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    Ömer Faruk Elmas

    2014-12-01

    Full Text Available Darier's disease is an inherited dermatosis of hair follicles characterized by hyperkeratotic papules. The trunk and scalp are usually affected. Comedonal Darier's disease is a rare subtype of Darier's disease. Comedonal lesions are seen beside the typical signs. Our case was a 59-yearold woman presented with hyperkeratotic papules and comedonal lesions on her bilateral axillary area and trunk, and below the breasts. Focal parakeratosis, acantholytic dyskeratotic cells in these focuses, basophilic nuclear dusts, clefts, edema and perivascular nonspecific mononuclear cells infiltrations in dermis were found in histopathological investigations. We decided to report this case because comedonal Darier is a rare form of Darier's disease and there are only few reported cases in the literature.

  6. Pyoderma gangrenosum with wrist joint destruction: case report.

    Science.gov (United States)

    Choe, Hyonmin; Sakano, Hiroaki; Takigami, Hidetake; Inaba, Yutaka; Matsuo, Kosuke; Saito, Tomoyuki

    2013-02-01

    Pyoderma gangrenosum (PG) is a rare, noninfectious, neurotrophic dermatosis. We observed a case of PG mimicking cutaneous and osteoarticular infections that presented with a prolonged ulcer on the forearm, severe wrist pain, anemia, substantial local and systemic inflammation as evaluated by serum laboratory data, and carpal osteolysis. Although PG rarely damages joints, the ulcer extended to the joint and destroyed the osteochondral tissues. Advanced ulcerative colitis, which is a most common comorbidity of PG, proved to be an underlying disease. Antibiotic and surgical treatment did not heal the ulcer, which was successfully treated with corticosteroids. This intractable ulcer is often misdiagnosed. Hence when a patient presents with an enlarged, painful, unusual skin lesion, PG should always be considered. Copyright © 2013 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

  7. IDIOPATHIC ERYTHEMA NODOSUM AND PREGNANCY: DESCRIPTION OF A CASE

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    B S Belov

    2009-01-01

    Full Text Available Erythema nodosum (EN is a dermatosis of unclear etiology, which is characterized by vascular lesion of the skin; it shows itself as hard painful nodes occurring in the derma or subcutaneous fat on the shins and thighs. EN has been described in many chronic infectious processes with some features of its clinical course. In most cases, the disease is regarded as a nonspecific immunoinflammatory response to a wide spectrum of etiological factors, including that in gestation, which presents certain problems in curing the patient. The example given below supports the need for timely testing for infectious markers in pregnancy and, in case of evolving EN, for using not only nonsteroidal anti-inflammatory drugs, but also pathogenetic treatment.

  8. Metastatic Calcinosis Cutis: A Case in a Child with Acute Pre-B Cell Lymphoblastic Leukemia

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    Juan Pablo Castanedo-Cázares

    2015-01-01

    Full Text Available Hypercalcemia in children with malignancy is an uncommon condition. It has been described in leukemia patients with impaired renal excretion of calcium or osteolytic lesions. Metastatic calcinosis cutis (MCC may develop if hypercalcemia persists. We report the case of a 5-year-old girl with an atypical dermatosis and unspecific gastrointestinal symptoms. Considered clinical diagnoses were xanthomas, histiocytosis, molluscum contagiosum, and nongenital warts. Cutaneous histological analysis showed amorphous basophilic deposits in the dermis suggestive of calcium deposits. Laboratory tests confirmed serum hypercalcemia. Extensive investigations such as bone marrow biopsy established the diagnosis of an acute pre-B cell lymphoblastic leukemia. Hypercalcemia in hematopoietic malignancies is unusual, especially as initial manifestation of the disease. Careful review of the literature fails to reveal previous reports of these peculiar cutaneous lesions of MCC in children with leukemia.

  9. Kyrle′s disease in a patient of diabetes mellitus and chronic renal failure on dialysis

    Directory of Open Access Journals (Sweden)

    Pragya A Nair

    2015-01-01

    Full Text Available Kyrle′s disease (KD is an acquired perforating dermatosis associated with an underlying disorder such as diabetes mellitus or chronic renal failure. It presents as multiple discrete, eruptive papules with a central crust or plug, often on the lower extremities. A keratotic plug is seen histologically in an atrophic epidermis and may penetrate the papillary dermis with transepidermal elimination of keratotic debris without collagen or elastic fibers. Various therapies have been reported that include cryotherapy, laser therapy, narrow-band ultraviolet B and use of topical or systemic retinoids. Hereby a case of 64-year-old male, a known case of diabetes mellitus, hypertension and chronic renal failure who developed KD is presented.

  10. THE HISTOPATHOLOGY OF PSORIASIS

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    C. Mignogna

    2011-09-01

    Full Text Available Psoriasis is a common, chronic, relapsing, papulo-squamous dermatitis, with overlying silvery scales. The scalp, sacral region, and extensor surfaces of extremity are commonly involved, even if flexural and intertriginous areas may be affected in the so-called “inverse psoriasis”. Involvement of nails is frequent. Oral lesions (geographic stomatitis and/or glossitis are commonly described. 5-8% of psoriatic patients develop arthritis. Interphalangeal joints are characteristically involved, but large joints are also affected. From a histological point of view, psoriasis is a dynamic dermatosis that changes during the evolution of an individual lesion; we can classify it in an early stage, advanced stage, and later lesions. Lesions are usually diagnostic only in early stages or near the margin of advancing plaques. Munro microabscesses and Kogoj micropustoles are diagnostic clues of psoriasis, but they aren’t always present. All other features can be found in numerous eczematous dermatitis. Key words: Psoriasis, histopathology, immunohistochemistry

  11. Treatment of adult diffuse pityriasis lichenoides chronica with narrowband ultraviolet B: experience and literature review.

    Science.gov (United States)

    Fernández-Guarino, M; Aboin-Gonzalez, S; Ciudad Blanco, C; Velázquez Tarjuelo, D; Lázaro Ochayta, P

    2017-04-01

    Pityriasis lichenoides chronica (PLC) is an infrequent dermatosis of unknown aetiology, wholse evolution and response to treatment differs between children and adults. When PLC is recalcitrant or unresponsive to topical treatment, phototherapy is one of the main treatments used. We carried out a prospective study of adult diffuse PLC treated with narrowband ultraviolet B (NB-UVB). We treated eight patients whose disease showed no response to topical therapy, and obtained a complete response rate of 88% in a mean of 23 sessions (cumulative dose 16.99 J/cm(2) ). However, the relapse rate was 43% in the first 6 months. Our results are similar to those of other published studies but there is much variability between them in the doses applied and the number of sessions needed. Further studies are necessary to devise a protocol for NB-UVB treatment of PLC. © 2017 British Association of Dermatologists.

  12. Ustekinumab in Psoriasis Immunopathology with Emphasis on the Th17-IL23 Axis: A Primer

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    Pascale Quatresooz

    2012-01-01

    Full Text Available Psoriasis is a chronic relapsing immunoinflammatory dermatosis that is commonly associated with systemic comorbidities. The pathogenic importance of interleukin (IL-12 and IL-23 is beyond doubt, as well as the involvement of T helper cells (Th1 and Th17 cells. There is upregulation of the p40 subunit shared by IL-12 and IL-23 and of the IL-23 p19 subunit, but not an increased expression of the IL-12 p35 subunit. This indicates that IL-23 appears more involved than IL-12 in the pathogenesis of psoriatic plaques. Ustekinumab is a fully human monoclonal antibody of the immunoglobulin (Ig G1 class targeting the p40 subunit common to both IL-12 and IL-23, thus inhibiting both IL-12 and IL-23 receptor-mediated signalling. Ustekinumab is part of the recent biologic therapies active in psoriasis, autoimmune arthritides, and inflammatory bowel diseases.

  13. Typical and atypical clinical appearance of atopic dermatitis.

    Science.gov (United States)

    Silverberg, Nanette B

    Atopic dermatitis is a complex, systemic inflammatory disorder associated with a variety of clinical features. The original criteria of Hanifin and Rajka include major criteria and a list of about two dozen minor criteria however, even the minor criteria do not include some features of atopic dermatitis noted less commonly but still seen with some frequency. This contribution first reviews the common clinical appearance of atopic dermatitis in infancy, childhood, and adulthood, as well as the less typical appearances, including lichenoid atopic dermatitis; juvenile plantar dermatosis; nummular-type atopic dermatitis; follicular atopic dermatitis; alopecia of atopic dermatitis; eczema coxsackium; and psoriasiform, perineal, and lip licker's dermatitis. The clinician will be able to recognize and treat rarer forms of atopic dermatitis and incorporate this into their daily practice. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Erythema elevatum diutinum as a first clinical manifestation for diagnosing HIV infection: case history

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    Patrícia Accioni Rover

    Full Text Available CONTEXT: Erythema elevatum diutinum is a chronic and rare dermatosis that is considered to be a variant of leukocytoclastic vasculitis. It is probably mediated by immune complexes. It is generally associated with autoimmune, neoplastic and infectious processes. Recently, it has been added to the group of specific dermatoses that are associated with HIV. CASE REPORT: We report on the case of a patient who had erythema elevatum diutinum as the first clinical evidence for diagnosing HIV infection. Dapsone was used in the treatment of this patient, and partial regression of the lesions was achieved within 15 days, even before antiretroviral therapy was prescribed. CONCLUSION: When there is a diagnosis of erythema elevatum diutinum, HIV infection should be investigated, especially in atypical and exacerbated clinical manifestations.

  15. Granuloma Faciale Treatment: A Systematic Review

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    Claudia Lindhaus

    2017-10-01

    Full Text Available Granuloma faciale is an uncommon benign chronic dermatosis characterized by reddish-brown to violaceous asymptomatic plaques appearing predominantly on the face. The pathogenesis of granuloma faciale remains unclear, and it is frequently unresponsive to therapy. This systematic review aims to summarize all recent publications on the management of granuloma faciale. The publications are mainly individual case reports, small case series and a few retrospective studies. Treatment options included topical, intralesional and systemic corticosteroids, topical pimecrolimus and tacrolimus, topical and systemic dapsone, systemic hydroxychloroquine, clofazimine, and tumour necrosis factor-alpha inhibitors. More invasive therapies using lasers as well as cryosurgery and surgery were also reported. Topical glucocorticosteroids and tacrolimus remain treatments of first choice, possibly supplemented by topical dapsone.

  16. Metastatic Calcinosis Cutis: A Case in a Child with Acute Pre-B Cell Lymphoblastic Leukemia.

    Science.gov (United States)

    Castanedo-Cázares, Juan Pablo; Reyes-Herrera, Amalia; Hernández-Blanco, Diana; Oros-Ovalle, Cuauhtémoc; Torres-Álvarez, Bertha

    2015-01-01

    Hypercalcemia in children with malignancy is an uncommon condition. It has been described in leukemia patients with impaired renal excretion of calcium or osteolytic lesions. Metastatic calcinosis cutis (MCC) may develop if hypercalcemia persists. We report the case of a 5-year-old girl with an atypical dermatosis and unspecific gastrointestinal symptoms. Considered clinical diagnoses were xanthomas, histiocytosis, molluscum contagiosum, and nongenital warts. Cutaneous histological analysis showed amorphous basophilic deposits in the dermis suggestive of calcium deposits. Laboratory tests confirmed serum hypercalcemia. Extensive investigations such as bone marrow biopsy established the diagnosis of an acute pre-B cell lymphoblastic leukemia. Hypercalcemia in hematopoietic malignancies is unusual, especially as initial manifestation of the disease. Careful review of the literature fails to reveal previous reports of these peculiar cutaneous lesions of MCC in children with leukemia.

  17. Coexistence of pemphigus foliaceus and acquired hemophilia A: A case report.

    Science.gov (United States)

    Filipczak, Aleksandra; Michalska-Jakubus, Małgorzata; Górska-Kosicka, Magdalena; Woźniak, Katarzyna; Kowalewski, Cezary; Krupski, Witold; Pietrzak, Aldona; Wallner, Grzegorz; Mosiewicz, Jerzy; Lotti, Torello; Krasowska, Dorota

    2015-06-01

    Pemphigus foliaceus (PF) is an autoimmune bullous dermatosis with anti-desmoglein-1 autoantibodies. Acquired hemophilia A (AHA) is a rare coagulation disorder with a high mortality rate, caused by anti-factor VIII immunoglobulin G antibodies leading to spontaneous severe hemorrhages into skin, muscles or soft tissues. This coagulopathy may be associated with malignancies, drug reactions and autoimmune disorders including bullous dermatoses. Herein, we demonstrate a first report of AHA in the course of pemphigus foliaceus. A 55-year-old woman presenting with extensive, erosive, crusted, scaly skin lesions was diagnosed with PF based on histopathological and immunofluorescent examination, confirmed by the presence of anti-desmoglein-1 antibodies on enzyme-linked immunoassay. She developed extensive internal hemorrhages and prolonged external bleeding after laparotomy. Based on coagulation tests, AHA was diagnosed. Simultaneous remission of pemphigus and coagulopathy occurred with immunosuppressants and recombinant activated factor VII. © 2015 Japanese Dermatological Association.

  18. Ketoconazole-induced Sweet syndrome: a new association.

    Science.gov (United States)

    Baquerizo Nole, Katherine L; Lee, Eric; Villada, Gabriel; Romanelli, Paolo

    2015-05-01

    Sweet syndrome (SS) is an acute febrile neutrophilic dermatosis that can be associated with malignancy and medications. A 60-year-old man presented with erythematous, edematous, and ulcerated plaques in the extensor surface of the upper extremities, after a ketoconazole course due to pityrosporum folliculitis. Skin biopsy showed a dense dermal neutrophilic infiltrate, associated with marked papillary dermal edema. Blood count showed leukocytosis and neutrophilia. Skin lesions resolved spontaneously with discoloration after 2 weeks of discontinuation of ketoconazole. Although most cases of drug-induced SS are associated with granulocyte colony-stimulating factor, other medications need to be considered. This is the first reported case of ketoconazole-induced SS despite its widespread use.

  19. [Prevalence of atopic dermatitis in 6-14 year old children in Morelia, Michoacan, Mexico].

    Science.gov (United States)

    Rodríguez Orozco, Alain R; Núñez Tapia, Rosa María

    2007-01-01

    Atopic dermatitis is a frequent chronic dermatosis in children. To determine the prevalence of atopic dermatitis in a pediatric population from Morelia, Michoacan. An observational, descriptive and comparative study was done to estimate the prevalence and underdiagnosis of atopic dermatitis in children and teenagers from Morelia, Michoacan (n=9578). This study had a sensitivity of 0.87 and a specificity of 0.92. A prevalence of 10.1% and 5.4% was found in children from 6 to 10 years old and teenagers from 11 to 16 years old. The diagnosis was done in only 20% of all cases. The high underdiagnosis suggests taking emergent actions of preventive medicine. The prevalence of atopic dermatitis in pediatric population from Morelia is similar of that reported in the United States and less than of Mexico City.

  20. (Industrial dermatoses among the Belthatow brown coal miners)

    Energy Technology Data Exchange (ETDEWEB)

    Ruszczak, Z.; Bienias, L.; Proszyncka-Kuczynska, W.

    1981-01-01

    443 subjects were examined, 235 applying to the physician due to the occurrence of skin dermatoses (group I) and 208 workers referred for periodic examinations (group II). In group I skin dermatoses were found in 100, i.e. 85%, of the subjects and in group II in 99 i.e. 48% of the subjects. In both groups the most frequent dermatosis was feet skin inflammation, especially interdigital intertrigo. Oil acne was diagnosed in 15, ordinary acne in 23, pityriasis versicolor in 19. erythrasma in 10, and eczema and contact dermatitis in 7 subjects of the first group and 3 subjects of the other group. 204 subjects with feet skin pathologies underwent mycologic examinations and 36 subjects--also bacteriologic examinations. The results of those studies indicate that in 23% of the subjects, feet interdigital intertrigo results from mycologic infections. Bacterial infections may contribute to etiopathogenesis. Imidazole compounds are useful for the treatment and prevention of interdigital intertrigo.

  1. Mesenchymal Stem Cell Therapy for Inflammatory Skin Diseases: Clinical Potential and Mode of Action.

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    Shin, Tae-Hoon; Kim, Hyung-Sik; Choi, Soon Won; Kang, Kyung-Sun

    2017-01-25

    Inflammatory skin disorders that cause serious deterioration of the quality of life have become one of the major public concerns. Despite their significance, there is no fundamental cure to date. Mesenchymal stem cells (MSCs) possess unique immunomodulatory properties which make them a promising tool for the treatment of various inflammatory diseases. Our recent preclinical and clinical studies have shown that MSCs can be successfully used for the treatment of atopic dermatitis (AD), one of the major inflammatory skin diseases. This observation along with similar reports from other groups revealed the efficacy and underlying mechanisms of MSCs in inflammatory dermatosis. In addition, it has been proposed that cell priming or gene transduction can be novel strategies for the development of next-generation high-efficacy MSCs for treating inflammatory skin diseases. We discuss here existing evidence that demonstrates the regulatory properties of MSCs on immune responses under inflammatory conditions.

  2. Multielemental analysis of samples from patients with dermatological pathologies using synchrotron radiation

    Science.gov (United States)

    Soares, J. C. A. C. R.; Canellas, C. G. L.; Anjos, M. J.; Lopes, R. T.

    2014-02-01

    Using synchrotron radiation total X-ray fluorescence (SRTXRF) technique, the concentrations of trace elements were measured in four skin lesions: seborrheic keratosis, fibroepithelial polyp, cherry angioma and dermatosis papulosa nigra. The concentrations of P, S, K, Ca, Fe, Cu, Zn and Rb were evaluated in 62 pairs of lesions and healthy samples, each one having been collected from the same patient. The results revealed significant differences of P, Ca, K, Fe and Cu levels as well as a common trend in their variations between lesion and control samples among the skin diseases. This study revealed a powerful tool that can be useful for skin disorders research. The measurements were conducted at Brazilian National Synchrotron Light Laboratory (LNLS).

  3. Association of Sweet's Syndrome and Systemic Lupus Erythematosus

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    J. L. Barton

    2011-01-01

    Full Text Available Sweet's syndrome is an acute febrile neutrophilic dermatosis which usually presents as an idiopathic disorder but can also be drug induced, associated with hematopoetic malignancies and myelodysplastic disorders, and more, infrequently, observed in autoimmune disorders. Sweet's syndrome has been reported in three cases of neonatal lupus, three cases of hydralazine-induced lupus in adults, and in nine pediatric and adult systemic lupus erythematosus (SLE patients. We describe three additional adult cases of Sweet's associated with SLE and provide a focused review on nondrug-induced, nonneonatal SLE and Sweet's. In two of three new cases, as in the majority of prior cases, the skin rash of Sweet's paralleled underlying SLE disease activity. The pathogenesis of Sweet's remains elusive, but evidence suggests that cytokine dysregulation may be central to the clinical and pathological changes in this condition, as well as in SLE. Further research is needed to define the exact relationship between the two conditions.

  4. Typically atypical: histiocytoid Sweet syndrome, associated with malignancy.

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    Hünermund, Anika; Wendel, Ana-Maria; Geissinger, Eva; Bröcker, Eva-Bettina; Stoevesandt, Johanna

    2011-09-01

    Sweet syndrome (acute febrile neutrophilic dermatosis) is characterized by a dramatic onset of high fever, neutrophilia and typical skin lesions. About 20 % of patients have an associated malignancy, most commonly hematologic diseases. Chronic and paucisymptomatic manifestations of Sweet syndrome may be misdiagnosed or misinterpreted as harmless, resulting in delayed diagnosis. "Atypical" manifestations are especially suspicious for associated malignancies. This is demonstrated by a 39-year old patient with chronic and afebrile disease who was referred to our clinic only after symptoms had persisted for several months. By that point, an underlying nodular lymphocyte predominant Hodgkin's lymphoma had already reached an advanced stage. Skin biopsies revealed dermal infiltrates of histiocytoid cells of myelogenous origin, supporting a diagnosis of histiocytoid Sweet syndrome. Specific cutaneous infiltrates associated with myelogenous leukemia were ruled out. © The Authors • Journal compilation © Blackwell Verlag GmbH, Berlin.

  5. Cutaneous findings in hairy cell leukemia. Review of 84 cases.

    Science.gov (United States)

    Carsuzaa, F; Pierre, C; Jaubert, D; Viala, J J

    1994-01-01

    The authors of this paper present a retrospective analysis of 84 cases of hairy cell leukaemia diagnosed over the past ten years in two haematology departments. Cutaneous manifestations are noted on 47 occasions, 58% of infectious origin with 60% of these infections due to bacterial agents, results which are in relatively close accord with those of the Mayo Clinic. Since no cases of necrotic angeitis or neutrophilic dermatosis are reported, the considerable number of publications concerning these affections give a poor indication of their rarity. Prospective studies will be required to evaluate the incidence of spinocellular carcinoma and melanoma, while specific lesions are only infrequently encountered and do not appear to bear the same unfavourable prognosis as in other haemopathia.

  6. Concomitant granular cell tumor and balanitis xerotica obliterans of the foreskin: A case report and literature review

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    Shaun AC Medlicott, MD, FRCPC

    2017-09-01

    Full Text Available Balanitis xerotica obliterans is a chronic dermatosis that frequently involves the glans penis and the foreskin. Granular cell tumor is a benign tumor that may rarely involve the penis, but involvement of the foreskin is exceedingly rare. It may result in thickening and ulceration of the overlying epidermis, which can mimic squamous cell carcinoma. An association of these two lesions, one very common and one extremely uncommon, arising concomitantly in the penile foreskin has not been previously documented. A 23-year-old patient with phimosis and a subcutaneous foreskin nodule presented for a medical circumcision. The microscopic examination demonstrated balanitis xerotica obliterans and granular cell tumor, occurring in continuity in the foreskin. To our knowledge, this is the first reported example of these two lesions arising simultaneously in the male genitalia.

  7. Granuloma Faciale Treatment: A Systematic Review.

    Science.gov (United States)

    Lindhaus, Claudia; Elsner, Peter

    2018-01-12

    Granuloma faciale is an uncommon benign chronic dermatosis characterized by reddish-brown to violaceous asymptomatic plaques appearing predominantly on the face. The pathogenesis of granuloma faciale remains unclear, and it is frequently unresponsive to therapy. This systematic review aims to summarize all recent publications on the management of granuloma faciale. The publications are mainly individual case reports, small case series and a few retrospective studies. Treatment options included topical, intralesional and systemic corticosteroids, topical pimecrolimus and tacrolimus, topical and systemic dapsone, systemic hydroxychloroquine, clofazimine, and tumour necrosis factor-alpha inhibitors. More invasive therapies using lasers as well as cryosurgery and surgery were also reported. Topical glucocorticosteroids and tacrolimus remain treatments of first choice, possibly supplemented by topical dapsone.

  8. Annular Lichenoid Dermatitis of Youth: A Report of 2 Cases and a Review of the Literature.

    Science.gov (United States)

    Vázquez-Osorio, I; González-Sabín, M; Gonzalvo-Rodríguez, P; Rodríguez-Díaz, E

    2016-01-01

    Annular lichenoid dermatitis of youth is a lichenoid dermatosis of unknown etiology. It mostly affects children and adolescents and has well-defined clinical and histological characteristics that permit a diagnosis. We present 2 new cases of annular lichenoid dermatitis of youth with classical clinical features in 2 girls, aged 2 and 4 years. The histologic findings, however, differed from those reported in the literature in that the lichenoid inflammatory infiltrate was located primarily at the top of the dermal papillae and not at the tips of the rete ridges. In both cases, the lesions regressed spontaneously without treatment. Copyright © 2016 AEDV. Published by Elsevier España, S.L.U. All rights reserved.

  9. The application of skin metabolomics in the context of transdermal drug delivery.

    Science.gov (United States)

    Li, Jinling; Xu, Weitong; Liang, Yibiao; Wang, Hui

    2017-04-01

    Metabolomics is a powerful emerging tool for the identification of biomarkers and the exploration of metabolic pathways in a high-throughput manner. As an administration site for percutaneous absorption, the skin has a variety of metabolic enzymes, except other than hepar. However, technologies to fully detect dermal metabolites remain lacking. Skin metabolomics studies have mainly focused on the regulation of dermal metabolites by drugs or on the metabolism of drugs themselves. Skin metabolomics techniques include collection and preparation of skin samples, data collection, data processing and analysis. Furthermore, studying dermal metabolic effects via metabolomics can provide novel explanations for the pathogenesis of some dermatoses and unique insights for designing targeted prodrugs, promoting drug absorption and controlling drug concentration. This paper reviews current progress in the field of skin metabolomics, with a specific focus on dermal drug delivery systems and dermatosis. Copyright © 2016. Published by Elsevier Urban & Partner Sp. z o.o.

  10. Skin manifestations of chronic kidney disease.

    Science.gov (United States)

    Robles-Mendez, J C; Vazquez-Martinez, O; Ocampo-Candiani, J

    2015-10-01

    Skin manifestations associated with chronic kidney disease are very common. Most of these conditions present in the end stages and may affect the patient's quality of life. Knowledge of these entities can contribute to establishing an accurate diagnosis and prognosis. Severe renal pruritus is associated with increased mortality and a poor prognosis. Nail exploration can provide clues about albumin and urea levels. Nephrogenic systemic fibrosis is a preventable disease associated with gadolinium contrast. Comorbidities, such as diabetes mellitus and secondary hyperparathyroidism, can lead to acquired perforating dermatosis and calciphylaxis, respectively. Effective and innovative treatments are available for all of these conditions. Copyright © 2015 Elsevier España, S.L.U. and AEDV. All rights reserved.

  11. Herpes zoster on segmental vitiligo: Wolf’s isotopic response?

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    Mankesh Lal Gambhir

    2014-04-01

    Full Text Available “Wolf’s isotopic response” describes the occurrence of a new skin disorder at the site of another, unrelated and already healed skin disease. In most cases of isotopic response, the initial dermatosis is herpes zoster, herpes simplex, varicella, thrombophlebitis, scrofuloderma and striae distense. The most frequent second dermatoses are granulomatous reactions, particularly granuloma annulare, and lichenoid diseases. Various etiological reasons including viral, immunologic, neural and vascular have been put forth. We report here a case in which the second disease was herpes zoster that appeared over the same dermatomes of pre-existing segmental vitiligo. The occurrence of vitiligo as first and herpes zoster as second disease in the “Wolf’s isotopic response” has not, to the best of our knowledge, been reported previously.

  12. An Adult Case of Lichen Striatus Whom Was Successfully Treated with Topical Pimecrolimus

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    Bengü Çevirgen Cemil

    2013-12-01

    Full Text Available Lichen striatus is an acquired, self-limited, and linear inflammatory dermatosis. Lichen striatus usually occurs in children between 5-15 years of age, and sex, racial or hereditary disposition are not seen. Lichen striatus has rarely seen in adults. 56-year-old female patient was admitted to our clinic with the complaint of itchy skin rash on his right leg. Dermatological examination showed brown, linear distributed, erythematous, and lichenoid papules from the knee to the dorsum of foot on the right leg. Because histopathologic examination of the punch biopsy taken from the leg found compatible with lichen striatus, the topical treatment was started. Complete recovery was obtained at the end of the 8 week. Hereby, we report an adult patient with lichen striatus showed good responce to topical pimecrolimus therapy.

  13. Granulosis rubra nasi – a case report. A literature review

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    Brzezinski Piotr

    2011-07-01

    Full Text Available Granulosis Rubra Nasi (GRN, a rare childhood dermatitis that was also defined as "Acne papulo-rosacea of the nose". Is an inflammatory dermatosis which consists on erythema, papules and itch. The hyperhidrosis the most conspicuous features of the disease and small beads of sweat and erythema on the tip of the nose may often occur. Sometimes small red papules and comedo-like lesions may be present. Etiology is unknown. lt's uncommon, chronic process and benign course. Usually subsides spontaneously at adolescence. The treatment is symptomatic and cosmetic. An 14-year-old boy presented with erythematous lesions over the nose of childhood duration without sensitivity to sunlight. Physical examination showed also excessive sweating of the nose, and erythema of the nose covered by small pustules, papules ang macules. The patient responded well to low doses of oral Isotretinoine. Should remember GRN could be a complication of hyperhidrosis.

  14. An unusual case of Sweet syndrome in a child: overlapping presentation with erythema elevatum diutinum.

    Science.gov (United States)

    Wang, Tingting; Liu, Hongjie; Wang, Lin; Guo, Zaipei; Li, Li

    2014-06-01

    In 1964, Sweet described an acute febrile neutrophilic dermatosis. It is now widely accepted that Sweet syndrome is one of the associated neutrophilic dermatoses. Herein, we describe an unusual case of Sweet syndrome in a 5-year-old child who suffered from recurrent papules, plaques, and blisters on his face and trunk after the initial onset of fever without an obvious cause. Two skin biopsies were performed. The histopathological findings of the left arm biopsy showed a subepidermal blister with dense infiltrating neutrophils within the blister that were superficial to the middle layer of the dermis. The biopsy from a plaque on the left leg showed a dense infiltrate of neutrophils and a large number of infiltrating histiocytes superficial to the middle layer of the dermis. Direct immunofluorescence of a skin biopsy from the left arm confirmed that immunoglobulin M (IgM), IgG, IgA, and C3 expression were negative.

  15. Occupational Dermatoses Among Kitchen Workers In A Chain Of Vegetarian Hotel

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    Rai Reena

    2003-01-01

    Full Text Available This study was undertaken to identify occupation related skin problems among hotel workers. One thousand three hindered and ninety employees of a chain of vegetarian hotels were examined. Of the 273 people working in the kitchen, 206 (75.4% had dermatosis related to work. The Kitchen workers were classified according to the type of work they routinely performed. Forty eight out of the 63 (76.1% cooks who were involved in stirring had callosity at sites of contact with ladle and 28 of the40 (70% cooks who were involved in frying had pigmentation and scars due to contact with hot oil and water. All the onion peelers had staining and fissuring of the palmer aspect of the fingers. Thirty two of the 46(69.5% vegetable cutters had callosity on the palm at areas of contact with knife. Poori markers had pigmentation and callosity of knuckles due to pressing the dough with their knuckles. Nine of the 12 (66% rice cleaners had chapping of nails. Seven of the 12 (58.3% paratha markers had erythema of palm due to contact with hot tava. Tandoori experts had singing of hair over right forearm. Two workers (0.73% had pigmentation of the face probably due to prolonged exposure to heat. Two of the16 (12.5% grinders had paronychia and onychomycosis due to constant contact with water and dough. Nine of the 15 (60% coconut graters had callosities of the palms. We conclude the minor occupational dermatosis is prevalent among kitchen workers employed in hotels

  16. A retrospective epidemiological study of skin diseases among pediatric population attending a tertiary dermatology referral center in Northern Greece

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    Vakirlis E

    2017-04-01

    Full Text Available Efstratios Vakirlis, Grigorios Theodosiou, Zoe Apalla, Michael Arabatzis, Elizabeth Lazaridou, Elena Sotiriou, Aimilios Lallas, Demetrios Ioannides First Department of Dermatology, Aristotle University Medical School, Thessaloniki, Greece Background: The incidence of skin diseases in children is influenced by hereditary, social, and environmental factors. The objective of this study was to determine the incidence of pediatric dermatoses at a University Hospital in Northern Greece. Patients and methods: We reviewed epidemiologic data of 940 patients, aged 0–18 years, who were referred to the outpatient clinic of a University Hospital between January 2013 and December 2015. Demographic data and the frequency of the various diagnoses in various age groups were studied. Results: Nine hundred and forty children and adolescents with 1020 diagnoses were included in the study (52.8% females and 47.2% males. The 10 most frequent diagnoses were: dermatitis/eczema (31.5%, viral infections (12.5%, pigmentary disorders (7.4%, melanocytic nevi (5.8%, alopecia areata (5.8%, acne (5.6%, nail disorders (3.3%, vascular malformations and hemangiomas (2.9%, psoriasis (2.6%, and bacterial infections (2.6%. Atopic dermatitis was the most prevalent dermatosis in all age groups accounting for a total of 20.9% of the study population. A remarkably high incidence of various forms of mastocytosis (2.2% was seen in our data. Conclusion: Atopic dermatitis is the most frequent pediatric dermatosis in all age groups. Viral infections, pigmentary disorders, and nevi account for a significant proportion of the referrals. The high incidence of mastocytosis in our study may be attributed to overdiagnosis, overestimation due to the relatively small study population, or it may represent the real incidence of mastocytosis in our region. The low incidence of acne in our study may be attributed to the fact that only severe cases are referred to our hospital. Keywords: epidemiology

  17. Modulation of Interleukin-8 and staphylococcal flora by Avène hydrotherapy in patients suffering from chronic inflammatory dermatoses.

    Science.gov (United States)

    Casas, C; Ribet, V; Alvarez-Georges, S; Sibaud, V; Guerrero, D; Schmitt, A-M; Redoulès, D

    2011-02-01

    A number of studies argue in favour of an important role of microbial colonization, in particular of Staphylococcus aureus, in triggering atopic dermatitis (AD) flare-up and psoriasis, in particular through the superantigenic properties of toxins generated by S. aureus. The aim of this study was to assess the efficacy of a 3-week Avène hydrotherapy on the skin surface of patients suffering from psoriasis or atopic dermatitis. Skin samples were taken from healthy subjects or atopic (n = 18) or psoriatic patients (n = 39) undergoing hydrotherapy at Avène at the beginning (D0) and the end of treatment (D18). The severity of the dermatosis was evaluated according to SCORing Atopic Dermatitis (SCORAD) or Psoriasis Area Severity Index (PASI) scores at D0 and D18. Marker of inflammation interleukin 8 (IL-8), S. aureus colonization (protein A) and enterotoxins were assessed in skin samples using RT-PCR. At D0, significant differences were observed between healthy subjects and atopic or psoriatic patients in all the parameters evaluated (IL-8, protein A). At the end of the hydrotherapy, a significant decrease in SCORAD was associated with a significant reduction of IL-8, S. aureus colonization and enterotoxin D in patients with atopic dermatitis. Similarly, a significant decrease in PASI was associated with a significant reduction of IL-8, S. aureus colonization and enterotoxin N in patients with psoriasis. This study demonstrates the positive effects of Avène hydrotherapy on the skin of patients suffering from chronic dermatosis, with decreased inflammation and reduced colonization by S. aureus. © 2010 The Authors. JEADV © 2010 European Academy of Dermatology and Venereology.

  18. A lipohydroxyacid-containing shampoo improves scalp condition and quality of life in patients with seborrheic dermatitis and light-to-moderate scalp psoriasis.

    Science.gov (United States)

    Seité, S; Paries, J; Reygagne, P; Hamidou, Z; Jouanique, C; Perez-Pala, G; Rougier, A

    2009-06-01

    Dandruff is a common scalp disorder affecting almost half of the post-pubertal population of any ethnicity and both genders. It is one of the major reasons for patients to consult a dermatologist and it is the cause of significant psychological and social distress. The aim of this open study was to evaluate the benefit of a 4-week treatment with a shampoo containing 0.1% lipohydroxyacid (LHA) and 1.3% salicylic acid on the scalp condition and on the quality of life of 275 volunteers with seborrheic dermatitis (SD) (n = 226) or light-to-moderate scalp psoriasis (SP) (n = 49). The clinical benefit of the treatment was assessed by scoring the following parameters, i.e., severity of the dermatosis, scaling, itching, excoriations, and superficial burning sensation. The impact on the quality of life was assessed using the Scalpdex, a questionnaire specially developed by Chen et al. for patients with scalp dermatitis, which includes 23 questions regarding the symptoms, functioning and emotions affected by scalp dermatosis. The shampoo used in this study was well tolerated. After a 4-week treatment, dermatologists noticed a significant clinical improvement of all the scalp parameters evaluated (i.e., the composite lesional score was improved in 91% and 77% of the patients with SD or SP respectively). The symptoms, functioning and emotions scores of quality of life were also significantly improved in relation to the improvement of scalp condition. This study not only allowed a better understanding of the SD and SP patient's profile but also demonstrated that the shampoo evaluated is a convenient, efficient, safe, and well-tolerated cosmetic treatment of SD and light-to-moderate SP improving greatly the quality of life of the treated patients.

  19. Skin diseases during floods in Thailand.

    Science.gov (United States)

    Vachiramon, Vasanop; Busaracome, Ploysyne; Chongtrakool, Piriyaporn; Puavilai, Siripen

    2008-04-01

    Floods are natural disasters that occur occasionally in Thailand. The most common form skin diseases due to floods are infectious dermatoses especially superficial fungal infection. However the microbiologic evidences have not been evaluated. To evaluate the most common skin diseases during floods and identify the organism that causes skin maceration at web space(s) of toes (Hong Kong foot). Patients who complained of skin problems were evaluated at the temporary outpatient clinic during October 2006. Skin specimens from all patients who had itches and skin maceration at web space(s) of toes were cultured. Ninety-six patients were evaluated (38 males and 58 females). Eczema was the most prevalent dermatosis, which accounted for 34.5% of the total skin problems and the great majority of these cases were irritant contact dermatitis. Sixteen cases presented with itch and skin maceration at web space(s) of toes. All of them were colonized with various microorganisms. Gram-negative bacilli were the most prevalent ones and were found in 14 out of 16 specimens. Fungal culture was positive in only two specimens. Eczema is the most common dermatosis during floods. Skin maceration at web space(s) of toes, which were thought to be fungal infection, are chronic irritant dermatitis with secondary bacterial colonization. Only a few cases were fungal infection. Microbiologic investigation should be done in these patients. Unfortunately, it is not practical in such a situation. Topical medications that have the combination of antiinflammatory, antibacterial and antifungal properties are the most suitable medications.

  20. Pemphigoid gestationis: a retrospective study in southwest Iran.

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    Sima Rassai

    2013-06-01

    Full Text Available Pemphigoid gestationis (PG is a rare autoimmune bullous dermatosis of pregnancy usually presents in the second or third trimester. It is characterized by pruritic, urticarial plaques with the development of tense vesicles and bullae within the lesions. Pathogenesis of PG is not fully established, however, most patients develop circulating autoantibodies targeting the bullous pemphigoid (BP 180 antigen. The aim of this work is to draw a profile of the epidemiology, clinical aspects, treatment and evolution of the disease by studying hospital series. We retrospectively investigated the 13 patients who were diagnosed with PG based on hospital data at the Referral Center of Southwest Iran located in Ahvaz city between March 2002 and March 2011. The age of onset was 21 to 40 years (mean age: 27.5 years. The onset of the disease occurred in the second trimester of pregnancy in 6 patients and in the third trimester of pregnancy in 4 patients. One patient had a flare up of disease during the first trimester and two out of cases in puerperium period. In all cases, pruritus was the first symptom, followed by an erythematous vesiculobullous eruption.  The diagnosis of PG was confirmed by skin biopsy. Ten out of the patients treated with oral corticosteroids (0.5-1 mg/kg/day, one of the patients underwent oral corticosteroids plus topical glucocorticoid and the last patient treated with topical glucocorticoid. PG remains a rare dermatosis of pregnancy. Our series had two particularities compared to other studies: high frequency in primigravida and the frequent involvement of the face. Additionally our study demonstrated that improvement could occur faster and provide acceptable management if the treatment of the patients would be implemented sooner.

  1. Vesicular LL-37 contributes to inflammation of the lesional skin of palmoplantar pustulosis.

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    Masamoto Murakami

    Full Text Available "Pustulosis palmaris et plantaris", or palmoplantar pustulosis (PPP, is a chronic pustular dermatitis characterized by intraepidermal palmoplantar pustules. Although early stage vesicles (preceding the pustular phase formed in the acrosyringium contain the antimicrobial peptides cathelicidin (hCAP-18/LL-37 and dermcidin, the details of hCAP-18/LL-37 expression in such vesicles remain unclear. The principal aim of the present study was to clarify the manner of hCAP-18/LL-37 expression in PPP vesicles and to determine whether this material contributed to subsequent inflammation of lesional skin. PPP vesicle fluid (PPP-VF induced the expression of mRNAs encoding IL-17C, IL-8, IL-1α, and IL-1β in living skin equivalents, but the level of only IL-8 mRNA decreased significantly upon stimulation of PPP vesicle with depletion of endogenous hCAP-18/LL-37 by affinity chromatography (dep-PPP-VF. Semi-quantitative dot-blot analysis revealed higher concentrations of hCAP-18/LL-37 in PPP-VF compared to healthy sweat (2.87±0.93 µM vs. 0.09±0.09 µM. This concentration of hCAP-18/LL-37 in PPP-VF could upregulate expression of IL-17C, IL-8, IL-1α, and IL-1β at both the mRNA and protein levels. Recombinant hCAP-18 was incubated with dep-PPP-VF. Proteinase 3, which converts hCAP-18 to the active form (LL-37, was present in PPP-VF. Histopathological and immunohistochemical examination revealed that early stage vesicles contained many mononuclear cells but no polymorphonuclear cells, and the mononuclear cells were CD68-positive. The epidermis surrounding the vesicle expresses monocyte chemotactic chemokine, CCL2. In conclusion, PPP-VF contains the proteinase required for LL-37 processing and also may directly upregulate IL-8 in lesional keratinocytes, in turn contributing to the subsequent inflammation of PPP lesional skin.

  2. VACUNAS CONTRA EL HERPESVIRUS BOVINO-1: UNA MIRADA DESDE EL PASADO HACIA EL FUTURO DE LA INMUNIZACIÓN Bovine Herpesvirus-1 Vaccine’s: A Look From The Past To The Immunization Future

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    JULIÁN RUIZ-SAENZ

    Full Text Available El herpesvirus Bovino-1 (BHV-1 es uno de los principales patógenos que afecta el ganado; la infección primaria se acompaña de varias manifestaciones clínicas tales como la rinotraqueitis, aborto, vulvovaginitis/balanopostitis pustular y en algunos casos, enfermedad neurológica. Luego de la recuperación, la infección persiste durante toda la vida del individuo en un estado de latencia en ganglios nervioso trigémino o sacro. La Organización Mundial de Sanidad Animal (OIE reporta que la vacunación contra el BHV-1 puede ser efectiva en reducir las manifestaciones clínicas y en consecuencia las pérdidas económicas, pero no logra proteger completamente de la infección. Es por esto que durante los últimos años se han desarrollado gran cantidad de agentes vacunales que van desde las vacunas clásicas inactivadas hasta aquellas que usan tecnología de DNA recombinante. El presente artículo se enfoca en presentar una actualización acerca de las vacunas más usadas desde hace ya varios años y resumir los avances más importantes en la generación de nuevas vacunas contra el BHV-1; tratando así de abrir un nuevo panorama para la generación de vacunas en Colombia.Bovine herpesvirus-1 is one of the most important pathogens of cattle; the primary infection is characterized by clinical manifestations such as infectious bovine rhinotracheitis, abortion, infectious pustular vulvovaginitis and in some cases, neurological signs. After recovering, the virus establishes viral latency in sensory neurons of trigeminal or sacral ganglia. The World Organization for Animal Health (OIE reports that vaccination against BHV-1 could be useful to reduce the clinical manifestations and in consequence the economic looses, but it can not protect against the infection. Therefore, a huge amount of vaccines have been developed that includes from classic inactivation to recombinant DNA technologies. This paper makes an updated review about the most used vaccines

  3. Bullous impetigo and pregnancy: Case report and review of blistering conditions in pregnancy.

    Science.gov (United States)

    Cohen, Philip R

    2016-04-18

     Bullous impetigo results from Staphylococcus aureus (S. aureus) release of exfoliative toxins type A and type B thatresults in flaccid, easily ruptured, bullae in the upper layers of the epidermis.  Physiologic, gestation-associated, and incidental skin changes can occur in pregnancy.  Blisters in pregnant women can occur secondary to either common skin disorders orspecific dermatoses of pregnancy.  To describe a pregnant woman with bullous impetigo and review bullous conditions in pregnant women.  PubMed was used to search the following terms, separately and in combination:  blister, blistering, bullous, gestationis, herpes, herpetiformis, impetigo, pemphigoid, pregnancy, pregnant, psoriasis, pustular, virus. All papers were reviewed and relevant manuscripts, along with their reference citations, were evaluated.  Flaccid, easily rupturing, pustules, which developed into superficial annular erosions with peripheral scale and central healing appeared in a woman of 7-weeks gestation and allergy to penicillin on her lower abdomen, suprapubic region, perineum, buttocks, and proximal legs.  A bacterial culture subsequently isolated methicillin-susceptible S. aureus.  All of the lesions resolved after treatment with clindamycin.  Bullous impetigo should be considered in the differential diagnosis of common skin diseases presenting as blistersin pregnant women.

  4. Mucocutaneous manifestations of acquired hypoparathyroidism: An observational study

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    Somenath Sarkar

    2012-01-01

    Full Text Available Hypoparathyroidism is a disorder of calcium and phosphorus metabolism due to decreased secretion of parathyroid hormone. Hypoparathyroidism can be hereditary and acquired. Acquired hypoparathyroidism usually occurs following neck surgery (thyroid surgery or parathyroid surgery. Along with systemic manifestations, hypoparathyroidism produces some skin manifestations. Lack of study regarding mucocutaneous manifestations of acquired hypoparathyroidism prompted us to undertake this study. To evaluate the mucocutaneous manifestations of acquired hypoparathyroidism. An observational study done in a tertiary care hospital of Kolkata by comprehensive history taking, through clinical examination and relevant laboratory investigations. Twenty-one patients were included in the study. The commonest form of acquired hypoparathyroidism was neck surgery (thyroidectomy and parathyroidectomy operation. Mucocutaneous manifestations were present in 76.19% of patients. The most frequent mucocutaneous manifestation was found in the hairs like the loss of axillary hair (61.9%, loss of pubic hair (52.38%, coarsening of body hair (47.62%, and alopecia areata (9.52%. The nail changes noted were brittle and ridged nail, followed by onycholysis, onychosezia, and onychomedesis. The most common skin features were xerotic skin in 11 patients (52.38%, followed by pellagra-like skin pigmentation, pustular psoriasis and acne form eruption, bullous impetigo, etc. Mucosa was normal in all the cases excepting the one which showed oral candidiasis.

  5. Natural history of impetigo

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    Dajani, Adnan S.; Ferrieri, Patricia; Wannamaker, Lewis W.

    1972-01-01

    Intensive observations on 37 children in a population with endemic skin infections provided an opportunity to study the interrelationships between and the significance of the bacterial genera commonly associated with impetigo. Cultures of the respiratory tract, three normal skin sites, and lesions, when present, were taken three times weekly from July to October 1969. Impetigo developed in all 37 children. Group A streptococci alone were recovered from 21% of 361 lesions, Staphylococcus aureus alone from 8%, Staphylococcus epidermidis alone from 5% and mixtures of streptococci and staphylococci from 61%. Vesicular or pustular lesions were more often pure streptococcal than pure staphylococcal. Streptococci alone were more often recovered from early stage lesions rather than from later ones. The pure staphylococcal lesions characteristically occurred early in the season whereas streptococcal or mixed lesions had later peaks. Serial observations on 74 lesions revealed longer persistence of streptococci than staphylococci in mixed lesions. In 85% of the instances the same streptococcal serotype was recovered repeatedly from an individual lesion, whereas staphylococcal types changed in 57% of instances. Phage type 75 accounted for the majority of staphylococcal isolates from all sites, whereas phage type 54 was recovered only from skin lesions. In contrast to streptococci, the site sequence of staphylococcal spread was from the nose to normal skin to skin lesions. These studies reveal important differences in the migration of staphylococci (as compared with streptococci) to various body sites and suggest a subsidiary role for staphylococci in nonbullous impetiginous lesions yielding both organisms. Images PMID:4263498

  6. A case of recurrent impetigo herpetiformis treated with systemic corticosteroids and narrowband UVB.

    Science.gov (United States)

    Bozdag, Kubra; Ozturk, Serap; Ermete, Murat

    2012-03-01

    Impetigo herpetiformis is a rare pustular eruption with usual onset during the third trimester of pregnancy. The disease tends to remit after delivery, but may recur in subsequent pregnancies. Here we present a recurrent case of impetigo herpetiformis with earlier onset and poor response to corticosteroids in the subsequent pregnancy. She had widespread, erythematosquamous patches with tiny superficial pustules in the third trimester of her first pregnancy. Histopathological and clinical findings were consistent with impetigo herpetiformis. She was treated with systemic prednisolone and had a healthy baby without any complication. Three years later, the patient presented with impetigo herpetiformis again in the second trimester of her second pregnancy. After six weeks of oral prednisolone treatment, the lesions improved, but there were still new pustule formations and narrowband ultraviolet B treatment was added. Skin eruption cleared and she had a healthy baby in the 38th week of her second pregnancy. The corticosteroid dose was tapered gradually and stopped after delivery. Early diagnosis and treatment is crucial in impetigo herpetiformis because of the risk of maternal and fetal complications. When prednisolone is not enough to control the eruption alone, narrowband UVB can safely be added to the treatment.

  7. Successful use of Intravenous Immunoglobulin For Recalcitrant Impetigo Herpetiformis: Case Report

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    Hayriye Sarıcaoğlu

    2012-06-01

    Full Text Available Impetigo herpetiformis (IH, if left untreated, is associated with a high rate of perinatal morbidity and mortality and may lead to the decision of termination of pregnancy. There are various and effective therapeutic agents available for the treatment of the disease. A 23-year-old woman with a history of plaque psoriasis presented with a sudden generalized pustular eruption on the 25th week of her first gestation. The diagnosis was made based on the clinical and histopathological findings. The patient was treated with systemic prednisolone (2 mg/kg/d first and, cyclosporine A (3 mg/kg/d was added to the treatment after two weeks because prednisolone was not effective alone. The lesions did not regress despite four weeks of combined treatment with prednisolone and cyclosporine. Intravenous immunoglobuline (IVIG (0.3 g/kg/d, 6 days was added on the 30th week of gestation and resulted in regression of cutaneous rashes. On the 33rd week of gestation, IVIG (0.7 g/kg/d, 3 days was repeated due to reactivation of pustules, and an improvement was observed. In this case report, we called attention to IVIG therapy in IH, for having the pregnancy continued enough for the fetal maturation before the delivery.

  8. Successful treatment of palmoplantar pustulosis with isotretinoin.

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    Wilken, Reason; Sharma, Ajay; Patel, Forum; Maverakis, Emanual

    2015-08-15

    Variably considered as a localized subtype of pustular psoriasis, palmoplantar pustulosis (PPP) is commonly treated with topical steroids, acitretin, and local phototherapy with oral or topical psoralen (PUVA). The utility of acitretin for PPP is limited by adverse effects such as myalgias and an extended risk of teratogenicity in female patients. Isotretinoin is a more tolerable retinoid with a shorter teratogenic window, but to date its effectiveness in PPP has not been reported. Herein we present two patients with PPP who responded well to isotretinoin treatment. Two patients with PPP refractory to topical therapies were started on acitretin. Both patients developed adverse effects (including headache, myalgias, and mood alterations) leading to acitretin discontinuation. Isotretinoin monotherapy was started in one patient resulting in significant clearing of palmar plaques and scale, and the addition of isotretinoin to UVA therapy resulted in near-complete clearing of recalcitrant plantar plaques in the second patient. Acitretin represents an important treatment for PPP, but is limited by adverse effects and extended teratogenicity. Our experience supports the utility of isotretinoin as a potential therapeutic alternative, which may be particularly beneficial in patients who are poor candidates for or unable to tolerate acitretin therapy.

  9. A Case Report of Incontinentia Pigmenti in a Newborn with Positive Family History Extending Over Three Generations

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    Seyedeh Fatemeh Khatami

    2017-06-01

    Full Text Available Background: Incontinentia pigmenti (IP, also known as Bloch-Sulzberger syndrome, is a rare X-linked dominant genodermatosis that presents at the time of birth or soon after birth with cutaneous manifestation. This disorder may also affect the ectodermal tissues, such as the central nervous system, skeletal system, eyes, hair, nails, and teeth. The dermatological findings occur in four successive phases.Case report: Herein, we presented the case of a two day-old female newborn with inflammatory vesiculopustular lesions on the right forearm and lower limbs, who was in a good general condition. The patient had a history of similar disease in three other members of her family, who had dental abnormalities as the most common non-cutaneous manifestation. This case report highlighted the importance of a detailed diagnostic workup for the newborns with pustular skin disease.Conclusion: IP is a rare, x-linked dominant genodermatosis with multiple organs involvement. Dermatological abnormalities are the most prominent manifestation. The diagnosis is based on the clinical findings, the presence of positive family history of skin vesiculopustular lesions support the diagnosis. The skin lesions do not require specific treatment and prognosis depend to other organs involvement.

  10. A role for b-cell-depleting agents in treating psoriatic skin lesions induced by tumor necrosis factor-alpha antagonists: A case report and literature review

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    Ancuta Codrina Mihaela

    2014-01-01

    Full Text Available Despite recent advances in understanding the pathological pathways, clinical pattern and management opportunities for new-onset psoriasis as a paradoxical adverse event in patients receiving TNF inhibitors for their immune-mediated disorder, there is a subset of patients who are either partial responders or non-responders, whatever the therapeutic scenario. We present the case of new-onset psoriasis and severe alopecia development in a case study of long-standing rheumatoid arthritis (RA treated with adalimumab (ADA and leflunomide. Since skin lesions and alopecia are resistant to the classic protocol (topical treatment, ADA discontinuation and RA becomes highly active, rituximab (RTX was started. Dramatic improvement in joint disease, total remission of alopecia and partial remission of pustular psoriasis were described after the first RTX cycle. Although B-cell-depleting agents result in controversial effects on psoriatic skin lesions, this is the first case of ADA-induced psoriasis and alopecia that improved under RTX, suggesting a possible role in treating such a patient population.

  11. Comparison of TLR-2, TLR-4, and antimicrobial peptide levels in different lesions of acne vulgaris.

    Science.gov (United States)

    Ozlu, Emin; Karadag, Ayse Serap; Ozkanli, Seyma; Oguztuzun, Serpil; Kilic, Murat; Zemheri, Ebru; Akbulak, Ozge; Akdeniz, Necmettin

    2016-12-01

    Recent studies have shown that tolls like receptors (TLRs) and antimicrobial peptides (hBD-1, cathelicidin) play an important role in the pathogenesis of acne vulgaris (AV). To evaluate and report the expression of TLR-2, TLR-4, hBD-1 and cathelicidin in different regions of skin in AV. This study was performed in 80 patients with AV and a control group of 20 healthy individuals. Skin biopsies were performed from 20 papular, 20 pustular, 20 comedonal and 20 nodular lesions of patients and 20 healthy volunteers. Expression levels of TLR-2, TLR-4, hBD-1 and cathelicidin in four separate areas (epidermis, dermis, inflammation region and skin appendages) were evaluated by immunohistochemical method. Further, these parameters were compared between different skin lesions. A significant difference was found between the levels of staining of TLR-2, TLR-4 and hBD-1 from the epidermis, inflammation region, dermis and skin appendages (p pathogenesis of AV and in the development of different acne types. We think that, better results could be obtained in treatment of AV with different treatment options targeted in regulation of TLR-2, TLR-4, hBD-1 and cathelicidin release.

  12. Analysis of intergenic spacer region length polymorphisms to investigate the halophilic archaeal diversity of stromatolites and microbial mats.

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    Leuko, S; Goh, F; Allen, M A; Burns, B P; Walter, M R; Neilan, B A

    2007-01-01

    Hamelin Pool in Western Australia is one of the two major sites in the world with active marine stromatolite formation. Surrounded by living smooth and pustular mats, these ancient laminated structures are associated with cyanobacterial communities. Recent studies have identified a wide diversity of bacteria and archaea in this habitat. By understanding and evaluating the microbial diversity of this environment we can obtain insights into the formation of early life on Earth, as stromatolites have been dated in the geological record as far back as 3.5 billion years. Automated ribosomal intergenic spacer analysis (ARISA) patterns were shown to be a useful method to genetically discriminate halophilic archaea within this environment. Patterns of known halophilic archaea are consistent, by replicate analysis, and the halophilic strains isolated from stromatolites have novel intergenic spacer profiles. ARISA-PCR, performed directly on extracted DNA from different sample sites, provided significant insights into the extent of previous unknown diversity of halophilic archaea within this environment. Cloning and sequence analysis of the spacer regions obtained from stromatolites confirmed the novel and broad diversity of halophilic archaea in this environment.

  13. Human and animal infections by vaccinia-like viruses in the state of Rio de Janeiro: a novel expanding zoonosis.

    Science.gov (United States)

    Schatzmayr, H G; Costa, R V C; Gonçalves, M C R; D'Andréa, P S; Barth, O M

    2011-12-30

    Since 1999, vesicular infections caused by Orthopoxvirus in humans and animals, mainly in dairy cattle, have been identified in 20 municipalities in the Rio de Janeiro state of Brazil. This paper describes studies conducted in counties of the northwestern, middle-Paraíba Valley and southern regions of the Rio de Janeiro state where 77 human, 346 bovine and 78 rodent samples were collected over the past ten years. Laboratory investigations using virus isolation, electron microscopy, molecular biology (PCR) and serological analysis confirmed Orthopoxvirus infections in 77.9% of human, 49.2% of dairy cattle and 17.9% of rodent samples. The characterisation of the Cantagalo/IOC strain reconfirmed that this virus was a vaccinia-like virus. In other regions of the Rio de Janeiro state, vesicular/pustular infections in animals and humans are suspected but these have not yet been confirmed. A continuous surveillance system has been established to monitor these regions in addition to several other states of the Brazilian Federation. Copyright © 2011 Elsevier Ltd. All rights reserved.

  14. Animal models of orthopoxvirus infection.

    Science.gov (United States)

    Chapman, J L; Nichols, D K; Martinez, M J; Raymond, J W

    2010-09-01

    Smallpox was one of the most devastating diseases known to humanity. Although smallpox was eradicated through a historically successful vaccination campaign, there is concern in the global community that either Variola virus (VARV), the causative agent of smallpox, or another species of Orthopoxvirus could be used as agents of bioterrorism. Therefore, development of countermeasures to Orthopoxvirus infection is a crucial focus in biodefense research, and these efforts rely on the use of various animal models. Smallpox typically presented as a generalized pustular rash with 30 to 40% mortality, and although smallpox-like syndromes can be induced in cynomolgus macaques with VARV, research with this virus is highly restricted; therefore, animal models with other orthopoxviruses have been investigated. Monkeypox virus causes a generalized vesiculopustular rash in rhesus and cynomolgus macaques and induces fatal systemic disease in several rodent species. Ectromelia virus has been extensively studied in mice as a model of orthopoxviral infection in its natural host. Intranasal inoculation of mice with some strains of vaccinia virus produces fatal bronchopneumonia, as does aerosol or intranasal inoculation of mice with cowpox virus. Rabbitpox virus causes pneumonia and fatal systemic infections in rabbits and can be naturally transmitted between rabbits by an aerosol route similar to that of VARV in humans. No single animal model recapitulates all known aspects of human Orthopoxvirus infections, and each model has its advantages and disadvantages. This article provides a brief review of the Orthopoxvirus diseases of humans and the key pathologic features of animal models of Orthopoxvirus infections.

  15. A study on the productivity and diseases of camels in eastern Ethiopia.

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    Tefera, M; Gebreah, F

    2001-07-01

    A study concerning performance traits of the Ethiopian camel indicated that, in the camel herds examined, there was one active bull camel for 25 females. The bull camel was 5 years old at puberty; it reached rutting vigour at the age of 9 years, the number of mountings per day was 8 during the breeding season, and the reproduction span was 10 years. The female camel reached puberty at 4 years of age; the age at first calving was 5 years, and the lactation period was one year; the calving interval was 2 years, the calving rate was 50%, and the reproduction span was 10-15 years. The survival rate of the newborn calves was 50%. The average milk yield was 2.5 L per day; the price of camel's milk was higher than that of cow's milk at US$0.5. Adult camels weighed around 500 kg; the dressing-out percentage was 52%. Mutton was preferred to camel meat, which came second in popularity, costing US$2/kg. Owing to their poor reproductive performance, camels are not efficient for producing meat. The camels worked for 16 h per day, covering 60 km. Animal health problems encountered were trypanosomosis, camel pox, camel pustular dermatitis, camel cephalopsis, dermatomycosis, mange mite, tick infestation and balantidiosis, most of which mainly affected the young animals.

  16. The SAPHO syndrome: defining the radiologic spectrum of diseases comprising the syndrome

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    Sugimoto, H.; Tamura, K. [Department of Radiology, Jichi Medical School, 3311 Minamikawachi-machi, Kawachi-gun, Tochigi-ken, 329-04 (Japan); Fujii, T. [Department of Pathology, Jichi Medical School, 3311 Minamikawachi-machi, Kawachi-gun, Tochigi-ken, 329-04 (Japan)

    1998-06-02

    The objective of our study was to clarify the radiologic spectrum of disease entities belonging to the SAPHO syndrome (SAPHO being an acronym for synovitis, acne, pustulosis, hyperostosis, and osteitis). A retrospective analysis of radiologic data was undertaken to determine the relationship of the osteoarthritic changes seen in palmoplantar pustulosis (PPP, n = 179), acne (n = 3), psoriasis vulgaris (PsV, n = 355), generalized pustular psoriasis (GPP, n = 25), and chronic recurrent multifocal osteomyelitis (CRMO, n = 4). Osseous changes of PPP, acne, and CRMO overlap each other; 7 PPP, 2 acne, and 3 CRMO patients manifested stenocostoclavicular hyperostosis as well as hyperostosis of the spine, pelvis, and/or femur. These findings were not seen in either PsV or GPP patients. Thirteen PsV and 4 GPP patients had peripheral arthritis and/or symmetrical sacroiliitis, which were not observed in the PPP, acne, and CRMO patients. The PPP, acne, and CRMO patients may be grouped as belonging to the single disease entity, namely SAPHO syndrome. Our findings do not support the inclusion of PsV and GPP in the spectrum of this syndrome. (orig.) With 7 figs., 2 tabs., 30 refs.

  17. SEQUENTIAL PATHOLOGICAL CHANGES IN TURKEYS EXPERIMENTALLY INFECTED WITH CHICKEN POX VIRUS

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    Muhammd Mubarak and Muhammad Mahmoud

    2000-01-01

    Full Text Available A total of 25, 4-weeks old, turkey poults were used in the present study. Birds were inoculated by chicken pox virus at the dose of 3 x l07.6/ml. Skin biopsy samples were taken sequentially from the same inoculated bird at 12 and 24 hours and at 2nd, 3rd, 4'h, 5th, 7th, l0th, 14th and 21 days post inoculation (PI. Tissue samples from upper respiratory and digestive tracts were also collected. Pox cytoplasmic inclusions (Bollinger bodies were detected between 4 and 7 days PI in epidermal the cell as well as in the follicular and sinus epithelium. Proliferative and necrobiotic epithelial changes were observed. Thereafter, pox inclusions disappeared with the appearance of vesicular, pustular and ulcerative lesions. This was accompanied by the gradual development of granulation tissue and finally scar tissue formed. Ultrastructure of the inclusion bodies and fine changes of the affected epidermal cell were illustrated.. It was concluded that the inoculated chicken pox virus is highly pathogenic for turkeys. Taking sequential biopsy samples from the same inoculated bird was found to yield more accurate follow up of the pox skin lesions.

  18. A Delphi Consensus Approach to Challenging Case Scenarios in Moderate-to-Severe Psoriasis: Part 2.

    Science.gov (United States)

    Strober, Bruce E; Clay Cather, Jennifer; Cohen, David; Crowley, Jeffrey J; Gordon, Kenneth B; Gottlieb, Alice B; Kavanaugh, Arthur F; Korman, Neil J; Krueger, Gerald G; Leonardi, Craig L; Schwartzman, Sergio; Sobell, Jeffrey M; Solomon, Gary E; Young, Melodie

    2012-12-01

    Clinicians may be confronted with difficult-to-treat psoriasis cases for which there are scant data to rely upon for guidance. To assist in managing such patients, who are typically excluded from clinical trials, a consensus panel of 14 experts in the field of psoriasis was formed to conduct a Delphi method exercise. The exercise consisted of both survey questionnaires and a live meeting to review and discuss current data (as of 2009, when the exercise was conducted) and arrive at a consensus for optimal treatment options. Seventy difficult treatment scenarios were identified, and the top 24 were selected for discussion at the live meeting. Five of the 24 discussed case scenarios are presented in this article: (1) moderate-to-severe psoriasis that has failed to respond to all currently approved therapies for psoriasis; (2) palmoplantar psoriasis that is unresponsive to topical therapy and phototherapy; (3) erythrodermic psoriasis; (4) pustular psoriasis; and (5) the preferred therapeutic choice to combine with low-dose methotrexate. A previous article (part 1) presented six other scenarios. The Delphi exercise resulted in guidelines for practicing physicians to utilize when confronted with patients with challenging cases of psoriasis.

  19. Survey of dermatological conditions in a population of domestic dogs in Mashhad, northeast of Iran (2007 - 2011

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    Javad Khoshnegah

    2013-06-01

    Full Text Available In order to assess the prevalence of skin diseases in dogs encountered in a first opinion university small animal clinic, 1299 Iranian domestic dogs presented from September 2007 through March 2011 to the Ferdowsi University of Mashhad Veterinary Teaching Hospital, were examined. Dermatological disorders were noted in 17.00% (221/1299 of all the dogs examined. Pruritus was the most common presenting sign, accounting for 25.35% of the dermatological consultations. It was followed by erythema, maculo-papular-pustular eruptions (16.97%, erosive or ulcerative lesions (16.74%, scaling or crusting (13.02%, alopecia (8.84% and visible ectoparasites (7.44%. The most common primary final diagnoses were superficial pyoderma, cutaneous manifestations of canine leishmaniasis, flea infestation and allergy, tick infestation, atopic dermatitis, scabies, unspecified dermatoses, otitis, furunculosis and food allergy. There were no apparent age or sex predilections for dermatological disease as a whole. Spitz (odds ratio = 3.38; p = 0.001, Terriers (odds ratio = 2.52; p < 0.001 and German Shepherds (odds ratio = 1.90; p = 0.001 appeared to be at increased risk for dermatological disease. In addition, Khorasani large cross breed dogs (odds ratio = 0.36; p = 0.003 and mixed breed dogs (odds ratio = 0.33; p < 0.001 showed decreased risk for dermatological conditions. To the best of our knowledge, this is the first survey study on canine dermatological conditions carried out in Iran.

  20. Systemic cyclosporine treatment in severe childhood psoriasis: A retrospective chart review.

    Science.gov (United States)

    Dogra, Sunil; Mahajan, Rahul; Narang, Tarun; Handa, Sanjeev

    2017-02-01

    Data regarding the use of cyclosporine (CYC) in the treatment of childhood psoriasis is meager. The records of all psoriasis patients aged less than 18 years and treated with systemic CYC at our institute were retrieved. Clinical status of patients was assessed at regular intervals and response to therapy was graded as good (50-75% decrease in PASI) and excellent (>75% decrease). Laboratory investigations to detect CYC-induced toxicity were done at regular intervals. There were total 10 children having psoriasis treated with systemic CYC over this period. Indication for the institution of CYC therapy was severe diseases, viz. extensive recalcitrant plaque type psoriasis in four patients, erythroderma in three and generalized pustular psoriasis in one patient. Response to therapy was excellent (>75% decrease in PASI) in all but three patients with psoriatic erythroderma. The mean time to control the disease, i.e. 50% reduction in PASI was 4.2 weeks. Side effects were mild, observed in two children, which included pain abdomen and an increase in serum creatinine over baseline value. CYC is an effective and reasonably safe drug to be used as crisis management therapy in severe childhood psoriasis under an expert supervision and laboratory monitoring.

  1. Pediculosis and scabies: treatment update.

    Science.gov (United States)

    Gunning, Karen; Pippitt, Karly; Kiraly, Bernadette; Sayler, Morgan

    2012-09-15

    Pediculosis and scabies are caused by ectoparasites. Pruritus is the most common presenting symptom. Head and pubic lice infestations are diagnosed by visualization of live lice. Finding nits (louse egg shells) alone indicates a historical infestation. A "no nit" policy for schools and day care centers no longer is recommended because nits can persist after successful treatment with no risk of transmission. First-line pharmacologic treatment of pediculosis is permethrin 1% lotion or shampoo. Multiple novel treatments have shown limited evidence of effectiveness superior to permethrin. Wet combing is an effective nonpharmacologic treatment option. Finding pubic lice should prompt an evaluation for other sexually transmitted infections. Body lice infestation should be suspected when a patient with poor hygiene presents with pruritus. Washing affected clothing and bedding is essential if lice infestation is found, but no other environmental decontamination is necessary. Scabies in adults is recognized as a pruritic, papular rash with excoriations in a typical distribution pattern. In infants, children, and immunocompromised adults, the rash also can be vesicular, pustular, or nodular. First-line treatment of scabies is topical permethrin 5% cream. Clothing and bedding of persons with scabies should be washed in hot water and dried in a hot dryer.

  2. Animal infections by vaccinia-like viruses in the state of Rio de Janeiro: an expanding disease Infecções animais por vírus semelhantes ao vaccínia no estado do Rio de Janeiro: uma doença em expansão

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    Hermann G. Schatzmayr

    2009-07-01

    Full Text Available In the present study we investigated the presence of infections by vaccinia-like viruses in dairy cattle from 12 counties in the state of Rio de Janeiro in the last 9 years. Clinical specimens were collected from adult animals with vesicular/pustular lesions mainly in the udder and teats, and from calves with lesions around the nose and mouth. A plaque reduction neutralization test (PRNT was applied to search for antibodies to Orthopoxvirus; the vesicular/pustular fluids and scabs were examined by PCR, electron microscopy (EM and by inoculation in VERO cells for virus isolation. Antibodies to Orthopoxvirus were detected in most cases. The PCR test indicated a high nucleotide homology among the isolates and the vaccinia viruses (VACV used as controls. By EM, typical orthopoxvirus particles were observed in some specimens. The agents isolated in tissue culture were confirmed as vaccinia-like viruses by EM and PCR. The HA gene of the vaccinia-like Cantagalo/IOC virus isolated in our laboratory was sequenced and compared with other vaccinia-like isolates, showing high homology with the original Cantagalo strain, both strains isolated in 1999 from dairy cattle. Antibodies to Orthopoxvirus were detected in one wild rodent (genus Akodon sp. collected in the northwestern region of the state, indicating the circulation of poxvirus in this area. Nonetheless, PCR applied to tissue samples collected from the wild rodents were negative. Vesicular/pustular lesions in people in close contact with animals have been also recorded. Thus, the vaccinia-like virus infections in cattle and humans in the state seem to be an expanding condition, resulting in economic losses to dairy herds and leading to transient incapacitating human disease. Therefore, a possible immunization of the dairy cattle in the state should be carefully evaluated.Neste estudo avaliou-se a presença de infecções por vírus semelhantes ao vírus vaccínia (VACV em gado leiteiro em 12 munic

  3. Study of efficacy of bath PUVA therapy in the treatment of generalized plaque type psoriasis

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    Azadeh S

    1999-09-01

    Full Text Available Psoriasis is a chronic, inflammatory scaling disorder of the skin. Different patterns of psoriasis exist including plaque type, erythrodemic, pustular, palmoplantar and guttate. The most commonly involved sites are the elbows, knees, lumbosacral area and scalp. PUVA (Psoriasis Plus UVA therapy [administration of oral psoralen followed by exposure to UVA (320 to 440 nm] is widely used to treat severe psoriasis. Oral PUVA produces some adverse effects that may limit its applicability in a number of patients. The carcinogenic potential limits its use in patients with psoriasis who probably receive other carcinogenic treatments. Oral PUVA may induce complications such as nausea, vomiting and headache. In light of these problems Bath PUVA therapy is an important alternative to oral PUVA therapy. Bath PUVA is a kind of photochemotherapy in which UVA radiation after administration of topical psoralen in a warm water bath is used. We treated 30 patients with generalized plaque type psoriasis with 8-Mop Bath PUVA in Razi hospital. Bath PUVA cleared psoriasis more rapidly than oral PUVA and required fewer treatments (mean number of sessions: (17.6±2.1 and lower cumulative UVA dose. (49.2±15.4 J/cm². 83.3 percent of our patients showed complete response to treatment and 13.4 percent showed good response.

  4. Pesti Des Petits ruminants virus infection in animals

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    Chauhan H.C.

    2009-08-01

    Full Text Available For centuries morbillivirus infections have had a huge impact on both human beings and animals. Morbilliviruses are highly contagious pathogens that cause some of the most devastating viral diseases of humans and animals world wide. They include measles virus (MV, canine distemper virus (CDV, rinderpest virus (RPV and peste des petits ruminants (PPRV virus. Furthermore, new emerging infectious diseases of morbilliviruses with significant ecological consequences of marine mammals have been discovered in the past decades. Phocid distemper virus (PDV in seals and the cetacean morbillivirus (CMV have been found in dolphins, whales and porpoises. Peste des petits ruminants (PPR is a highly contagious ,infectious , an acute or sub acute viral disease of domestic and wild small ruminants characterized by fever, oculonasal discharges, stomatitis, conjunctivitis, gastroenteritis and pneumonia. Goats are more severely affected than sheep. It is also known as pseudorinderpest of small ruminants, pest of small ruminants, pest of sheep and goats, kata, stomatitis- pneumoentritis syndrome, contagious pustular stomatitis and pneumoentritis complex. It is one of the major notifiable diseases of the World Organization for Animal Health (OIE. [Vet. World 2009; 2(4.000: 150-155

  5. A comparative split-face study of photodynamic therapy with indocyanine green and indole-3-acetic acid for the treatment of acne vulgaris.

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    Jang, M S; Doh, K S; Kang, J S; Jeon, Y S; Suh, K S; Kim, S T

    2011-11-01

    Recently, photodynamic therapy (PDT) using a variety of light sources and photosensitizers has been used for the treatment of acne vulgaris. PDT with aminolaevulinic or methylaminolaevulinic acid has also been used in clinical trials as a treatment for acne, but adverse effects such as pain, erythema and pustular eruption are common. Indocyanine green (ICG) and indole-3-acetic acid (IAA), newer photosensitizers, are known to have minimal adverse effects. This study was designed to compare the safety and efficacy of PDT using ICG and PDT using IAA in the treatment of mild to moderate acne vulgaris. In this prospective, single-blind, clinical trial, 34 patients with mild to moderate acne were treated with IAA with green light (520 nm) on half of the face and with ICG with near-infrared radiation (805 nm) on the other half. The procedure was carried out five times at 1-week intervals. With regard to acne lesions (inflammatory and noninflammatory) and sebum secretion, there were statistically significant reductions at each time point compared with the baseline values (P treatment types (P > 0·05). Both ICG-PDT and IAA-PDT showed better responses for inflammatory lesions than for noninflammatory lesions (P treatment as well as at 1, 2 and 3 months follow-up (P treatment of mild to moderate acne vulgaris. © 2011 The Authors. BJD © 2011 British Association of Dermatologists.

  6. Pilot study on which foods should be avoided by patients with psoriasis.

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    Festugato, Moira

    2011-01-01

    FUNDAMENT: Psoriasis is a chronic inflammatory systemic disease mediated by immune factors. We will explore the foods that act on these factors contributing to psoriasis. As a systemic disease, which shares the same pathophysiological substrate with other comorbidities, diet also leads to worsening of comorbidities. To indicate a group of foods that can act as a factor of manifestation and/or aggravation of psoriasis and, at the same time, enable strategies for individuals to introduce these foods to their diet. 43 patients with various forms of psoriasis (excluding pustular and erythrodermic psoriasis) were selected and answered a questionnaire about their eating habits in the first visit, with special attention to the consumption of black coffee, black tea, chocolate, yerba mate, pepper, smoked foods, beef and flavor enhancer (monosodium glutamate). Next, the patient was instructed to suspend alcoholic drinks and tobacco. Beef is the most consumed food by patients followed by MSG (monosodium glutamate), which exists in processed foods, yerba matte, black coffee, chocolate, smoked foods, pepper and black tea. 88.37% noticed reduced scaling and erythema, milder outbreaks during the year and improved quality of life; 11.63% (5 patients) did not notice any effects on the skin. We found poor dietary intake in patients with psoriasis. In addition to receiving proper scientific advice, patients need to be educated regarding their eating habits for a better quality of life and as an adjuvant to the drug therapy.

  7. [Fungemia due to Trichosporon asahii in a patient with hematological malignancy].

    Science.gov (United States)

    Odero, Valle; Galán-Sánchez, Fátima; García-Agudo, Lidia; García-Tapia, Ana M; Guerrero-Lozano, Inmaculada; Rodríguez-Iglesias, Manuel A

    2015-01-01

    Trichosporonosis is an opportunistic infection caused by the genus Trichosporon. The majority of cases of invasive trichosporonosis occurs in immunocompromised individuals. We describe a case of disseminated infection by Trichosporon asahii in a hematology patient. A 52-year-old man diagnosed with acute lymphoblastic leukemia developed a febrile episode during the third cycle of the induction chemotherapy. The blood cultures were positive after 24h incubation, showing elongated structures compatible with fungal elements in the Gram stain. The identification of the fungus as Trichosporon asahii was carried out by the assimilation of compounds of carbon and the amplification and sequencing of the D1/D2 domain and the internal transcribed spacer of the ribosomal DNA. The fungus was also isolated from the pustular lesions that the patient had in the chest. After treatment with amphotericin B, the patient progressed satisfactorily. Trichosporon asahii is an emergent pathogen in immunosupressed patients and its presence should not be considered as colonization, as there is risk of invasive infection. Copyright © 2013 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.

  8. Clinical and Epidemiologic Characteristics of Patients with Childhood Psoriazis Seen in Dermatology Clinic

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    Emine Elvan Taşğın

    2013-06-01

    Full Text Available Objective: To evaluate the epidemiologic characteristics of the pediatric patients with psoriazis applied to our outpatients' clinic and compare these data with the literature. Methods: The study population consisted of 37 patients younger than 16 years with the diagnosis of psoriazis in dermatology outpatient clinic between May 2009 and December 2010. The patients were evaluated with regard to age, gender, age of onset of the disease, duration of the disease, the presence of accompanying diseases, family history, clinical features, and triggering factors. Results: Of 37 pediatric patients with psoriazis evaluated in this study, 21 were girls and 16 were boys. The ages of the patients ranged between 2 and 15 years. 32.4% of the patients had family history. Plaque (59.45% of the patients, guttate (29.7% of the patients and pustular (10.8% of the patientstypes of psoriazis were determined. The psoriazis lesions involved most frequently the hairy skin (73% and the disease generally originated from this region. Ungual involvement was determined in 27% of the patients. None of the patients had psoriatic arthritis. Conclusion: Our study might contribute to generate epidemiological data's about the pediatric patients with psoriazis in our population.

  9. Molecular defects in the mannose binding lectin pathway in dermatological disease: Case report and literature review

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    Youngberg George

    2010-03-01

    Full Text Available Abstract Mannose-binding lectin (MBL and the Mannose-binding lectin-associated serine proteases (MASPs are an essential aspect of innate immune responses that probably play an important but understudied role in cutaneous function. The MBL-MASP pathway appears to exert its primary role by assisting in the clearance of apoptotic skin cells (thus preventing accumulation and a subsequent autoimmune response and promoting opsonophagocytosis of invading pathogens, limiting their dissemination. Deficiencies of the pathway have been described and are associated with infectious, autoimmune and vascular complications. However, the role of this pathway in dermatological disease is essentially unexplored. We describe 6 patients presenting with recurrent inflammatory and/or infectious skin conditions who also demonstrated severely low MBL levels. One patient also had a defect in the MASP2 gene. Genotype analysis revealed specific point mutations in the MBL2 promoter in all 6 patients and a variant MASP-2 gene in one patient. Five patients presented recurrent pustular skin infections (cellulitis, folliculitis and cutaneous abscess. A case of Grover's disease and one forme fruste of Behcet's syndrome (orogenital ulcers were also observed. The patients responded to antimicrobial therapy, although in some, recurrence of infection was the rule. It appears that MBL deficiency may contribute to recurrent skin infections and to certain forms of inflammatory skin disease. The mechanisms may relate to the role of this pathway in innate immunity, removal of apoptotic cells and in immune complexes. Further study of MBL pathway defects in dermatological disease is required.

  10. Pustulosis exantemática aguda generalizada asociada a Epstein Barr: A propósito de un caso. Acute generalized exanthematous pustulosis associated to Epstein Barr: A propose of a case

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    A L Scaglione

    2008-12-01

    Full Text Available La pustulosis exantemática aguda generalizada (PEAG es una rara afección de hipersensibilidad, inducida principalmente por drogas y se manifiesta por una erupción aguda de pústulas estériles, acompañada de fiebre, que regresa en pocos días luego de discontinuar el fármaco causante. Se comunica el caso de una paciente de 23 años de edad, sin antecedentes de psoriasis que consulta por fiebre y una erupción pustulosa generalizada, asociada a la ingesta previa de amoxicilina y ácido clavulánico en el contexto de una mononucleosis infecciosa, con resolución espontánea del cuadro. El cultivo microbiológico no objetivó gérmenes patógenos.Acute generalized exanthematous pustulosis (AGEP is a rare skin eruption most commonly caused by medications. It is characterized by an acute eruption of sterile pustules and it is accompanied by an episode of fever, which regresses a few days after discontinuation of the drug that caused the condition. We report a case 23 year-old woman without history of psoriasis, that consults for fever and an acute generalized pustular eruption after amoxicillin, with clavulanic acid administration in a mononucleosis infection context, which resolved spontaneously. The microbiologic culture was negative for pathogenic germens.

  11. Crusted Demodicosis in an Immunocompetent Pediatric Patient

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    Guillermo Antonio Guerrero-González

    2014-01-01

    Full Text Available Demodicosis refers to the infestation by Demodex spp., a saprophytic mite of the pilosebaceous unit. Demodex proliferation can result in a number of cutaneous disorders including pustular folliculitis, pityriasis folliculorum, papulopustular, and granulomatous rosacea, among others. We report the case of a 7-year-old female presenting with pruritic grayish crusted lesions over her nose and cheeks, along with facial erythema, papules, and pustules. The father referred chronic use of topical steroids. A potassium hydroxide mount of a pustule scraping revealed several D. folliculorum mites. Oral ivermectin (200 μg/kg, single dose plus topical permethrin 5% lotion applied for 3 consecutive nights were administered. Oral ivermectin was repeated every week and oral erythromycin plus topical metronidazole cream was added. The facial lesions greatly improved within the following 3 months. While infestation of the pilosebaceous unit by Demodex folliculorum mites is common, only few individuals present symptoms. Demodicosis can present as pruritic papules, pustules, plaques, and granulomatous facial lesions. To our knowledge, this is the first reported case of facial crusted demodicosis in an immunocompetent child. The development of symptoms in this patient could be secondary to local immunosuppression caused by the chronic use of topical steroids.

  12. [The prevalence of Demodex sp. in patients admitted to the parasitology laboratory of the Dursun Odabaş Medical Center in Yüzüncü Yıl University, Van].

    Science.gov (United States)

    Cengiz, Zeynep Taş; Yılmaz, Hasan; Özkol, Hatice Uce; Ekici, Abdurrahman; Ödemiş, Nuriz

    2014-01-01

    The aim of the study was to determine the prevalence of Demodex sp. in patients referred fom the Dermatology Outpatient Clinic to the Parasitology Laboratory, Dursun Odabaş Medical Center of the Yüzüncü Yıl University. The study was conducted between May 2012-May 2013. The samples were taken from 67 patients using the standard skin surface biopsy method. Demodex sp. mites were identified in 47.4% of 38 women, and in 48.3% of 29 male patients. These mites were detected in 15.8% of 19 patients who were 35 years old and younger, and in 60.4% of 48 patients who were 36 years old and older. Overall, 47.8% (32 patients) of 67 patients were found positive for demodicosis. It was determined that 53.1% of Demodex sp. positive patients had eritemato telangiectatic rosacea, 21.9% had papulo-pustular type rosacea, 18.8% had papules, 3.1% had erythematous pustules, and 3.1% had erythematous squamous plaques. There was a statistically significant difference between the Demodex sp. positivity and age groups (p=0.001). It was concluded that dermatologists should also take into consideration the possible presence of Demodex sp. mites in patients with skin symptoms such as erythema, telangiectasia, papules and pustules, and apply the appropriate treatment for these parasites.

  13. The pathogenesis of Demodex folliculorum (hair follicular mites) in females with and without rosacea.

    Science.gov (United States)

    el-Shazly, A M; Ghaneum, B M; Morsy, T A; Aaty, H E

    2001-12-01

    In rosacea patients (ages 11-50 years old) 44% were infested with D. folliculorum as compared to normal controls (23.0%). The difference was significant. The mean +/-SD of mite density ranged between 13.2+/-0.9 to 18.2+/-1.2 as compared to normal controls with mite density ranged between 1.4+/-0.25 to 2.4+/-0.3. Demodex infestation in rosacea patients was 66.1% in squamous, 66.7% in erythemato-telangiectate and 83.3% in papulo-pustular rosacea. The highly infested site was check (27.3%) with mean mite density of 25.3+/-1.3, followed by the area around the orbit (23.4%) with a density of 19.0+/-1.2, the area around the nose (19.5%) with mite density of 7.1+/-1.5, then chin (15.6%) with a density of 8.2+/-1.4 and lastly the area around the mouth (14.1%) with a mite density of 14.2+/-1.3. Undoubtedly, infestation with D. folliculorum particularly in large number causes rosacea.

  14. Crusted Demodicosis in an Immunocompetent Pediatric Patient

    Science.gov (United States)

    Gómez-Flores, Minerva; Ocampo-Candiani, Jorge

    2014-01-01

    Demodicosis refers to the infestation by Demodex spp., a saprophytic mite of the pilosebaceous unit. Demodex proliferation can result in a number of cutaneous disorders including pustular folliculitis, pityriasis folliculorum, papulopustular, and granulomatous rosacea, among others. We report the case of a 7-year-old female presenting with pruritic grayish crusted lesions over her nose and cheeks, along with facial erythema, papules, and pustules. The father referred chronic use of topical steroids. A potassium hydroxide mount of a pustule scraping revealed several D. folliculorum mites. Oral ivermectin (200 μg/kg, single dose) plus topical permethrin 5% lotion applied for 3 consecutive nights were administered. Oral ivermectin was repeated every week and oral erythromycin plus topical metronidazole cream was added. The facial lesions greatly improved within the following 3 months. While infestation of the pilosebaceous unit by Demodex folliculorum mites is common, only few individuals present symptoms. Demodicosis can present as pruritic papules, pustules, plaques, and granulomatous facial lesions. To our knowledge, this is the first reported case of facial crusted demodicosis in an immunocompetent child. The development of symptoms in this patient could be secondary to local immunosuppression caused by the chronic use of topical steroids. PMID:25371830

  15. Incidence of Demodex folliculorum in patients with end stage chronic renal failure.

    Science.gov (United States)

    Karincaoglu, Yelda; Esrefoglu Seyhan, Muammer; Bayram, Nalan; Aycan, Ozlem; Taskapan, Hulya

    2005-01-01

    Demodex folliculorum (DF), found in the pilosebaceous unit, is the most common ectoparasite in humans. It has been implicated in various clinical lesions such as pustular folliculitis, papulopustular scalp eruption, perioral dermatitis, and skin lesions of immunosuppressed patients on chemotherapy or with acquired immunodeficiency syndrome (AIDS). We aimed to determine DF carriers and location of DF among patients on chronic dialysis because of end stage renal failure (ESRF), to compare them with healthy controls, and to examine the relationship between DF incidence and dialysis method and symptoms. Sixty-seven patients on dialysis and 67 healthy controls were taken into the study. The patient groups were classified according to the diseases causing ESRF [diabetes mellitus (DM), polycystic disease (PCD), glomerulonephritis (GN), hypertensive nephrosclerosis (HTNS), others (OT), unknown etiology (UE)], and mode of dialysis. Five standardized skin surface biopsies (SSSB) were taken. The determination of five and more living parasites/cm2 area was diagnosed as infestation. The mean mite count in the ESRF group, 6.12/cm2, was significantly higher than that in controls, 0.31/cm2, (Independent Samples Test, p=0.000). The DF positivity according to primary disease causing ESRF revealed that it was most frequent in DM with 12 patients (44.4%), followed by UE with nine patients (33.4%). Our findings indicate that the DF number is increased in ESRF patients on dialysis treatment. We recommend that demodicidosis should be included in the differential diagnosis of facial eruptions in patients with ESRF.

  16. [Acute generalized exanthematous pustulosis induced by piroxicam].

    Science.gov (United States)

    Bissinger, Ingrid; Matute-Turizo, Gustavo; Mejía-Barreneche, María Natalia

    2016-01-01

    Between 62 and 90% of cases of acute generalized exanthematous pustulosis are caused by drugs. Its onset is rapid with generalized pustules, fever, and blood neutrophil count over 7000; pustules resolve spontaneously in less than 15 days. A case associated with piroxicam described. A 36-year-old with initial erythema of the thorax and abdomen, accompanied by burning, without fever, which later spread to his forearms, upper arms, and thighs, with face edema. A week earlier he had taken piroxicam for low back pain; at the time of hospitalization he received antihistamines, and topical and systemic steroids. Full blood count showed leukocytes at 8920, eosinophils at 600, neutrophils at 6600, total serum IgE at 188 UI, C-reactive protein at 2.9 mg/L, and no liver, kidney, or lung involvement. Treatment was initiated with intravenous antihistamines and ranitidine, saline, topical Vaseline plus topical mupirocin, and systemic steroids. On the second day of hospitalization neutrophils increased to 9000 and PCR to 3.3. The score to evaluate acute exanthematous pustulosis in the patient was 8, giving a definitive diagnosis. The differential diagnosis should be established primarily with pustular psoriasis. The prognosis is generally good, as reported.

  17. Clinical experience with systemic cyclosporine A treatment in severe childhood psoriasis.

    Science.gov (United States)

    Bulbul Baskan, Emel; Yazici, Serkan; Tunali, Sukran; Saricaoglu, Hayriye

    2016-08-01

    Severe forms of psoriasis including erythrodermic or pustular psoriasis, which require a more aggressive therapeutic approach such as phototherapy or systemic therapies, are rarely seen. Systemic toxicity and long-term safety of these agents are serious concerns in children. We report our experience on the efficacy and safety of cyclosporine A treatment in 22 patients of childhood psoriasis. We retrospectively analyzed the records of all patients less than 18 years of age treated with systemic cyclosporine A therapy at our clinic between January 2000 and March 2009. Demographic features as well as other relevant data including previous therapies, the dosage and duration of cyclosporine A therapy, response to treatment and side effects were retrieved from the patients' records. A total of 22 children were treated with systemic cyclosporine A therapy. Seventeen patients were found to be excellent responders. The mean therapeutic dosage of cyclosporine A was 3.47 ± 0.62 mg/kg/day. The mean duration of cyclosporine A therapy was 5.68 ± 3.29 months. The median time to total clearance of the lesions was 4.0 weeks. We conclude that cyclosporine A therapy is equally effective and safe in pediatric psoriasis patients as in adults.

  18. Sinonasal Melioidosis in a Returned Traveller Presenting with Nasal Cellulitis and Sinusitis

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    Rebecca Sin Mei Lim

    2013-01-01

    Full Text Available We illustrate a case involving a 51-year-old man who presented to a tertiary hospital with sepsis secondary to an abscess of the nasal vestibule and pustular eruptions of the nasal mucosa. Associated cellulitis extended across the face to the eye, and mucosal thickening of the sinuses was seen on computed tomography. The patient underwent incision and drainage and endoscopic sinus surgery. Blood cultures and swabs were positive for a gram-negative bacillus, Burkholderia pseudomallei. He had multiple risk factors including travel to an endemic area. The patient received extended antibiotic therapy in keeping with published national guidelines. Melioidosis is caused by Burkholderia pseudomallei, found in the soil in Northern Australia and Asia. It is transmitted via cutaneous or inhaled routes, leading to pneumonia, skin or soft tissue abscesses, and genitourinary infections. Risk factors include diabetes, chronic lung disease, and alcohol abuse. It can exist as a latent, active, or reactivated infection. A high mortality rate has been identified in patients with sepsis. Melioidosis is endemic in tropical Northern Australia and northeastern Thailand where it is the most common cause of severe community-acquired sepsis. There is one other report of melioidosis in the literature involving orbital cellulitis and sinusitis.

  19. Reduction of erythema in hairless guinea pigs after cutaneous sulfur mustard vapor exposure by pretreatment with niacinamide, promethazine and indomethacin

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    Yourick, J.J.; Dawson, J.S.; Mitcheltree, L.W.

    1995-12-31

    Erythema is the initial symptom that occurs after sulfur mustard (HD) cutaneous exposure. The time course of HD-induced erythema is similar to that observed after UV irradiation, which can be reduced by indomethacin. Sulfur mustard lethality is decreased by using promethazine, which is an antihistamine. Niacinamide can reduce microvesication after HD vapor exposure in hairless guinea pig (HGP) skin. The present study examines the effect of the combined administration of niacinamide, indomethacin and promethazine used alone or in all possible combinations on the degree of erythema and histopathologic skin damage after HD exposure in HGP. Niacinamide (750 mg kg%`, i.p.), promethazine (12.5 mg kg%1, i.m.) or indomethacin (4 mg kg%1, p.o.) used singly or in combination was given as a 30-min pretreatment before an 8-min HD vapor cup skin exposure. Using a combination pretreatment of niacinamide, promethazine and indomethacin, erythema was reduced at 4 (91%) and 6 (55%) h, but not 24 h after HD. The incidence of histopathological skin changes (microvesicles, follicular involvement, epidermal necrosis, intracellular edema and pustular epidermatitis) 24 h after HD was not reduced. This study indicates that HD (induced erythema) may result from several different mechanisms, including inflammation, histamine release and DNA damage. It is suggested that two phases of inflammation may occur: an early phase sensitive to antihistamines and non-steroidal antiinflammatory drugs and a late phase of extensive cell damage that was not sensitive to these drug pretreatments.

  20. Skin Manifestations of Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, and Spondyloarthritides.

    Science.gov (United States)

    Chua-Aguilera, Carolyn Jean; Möller, Burkhard; Yawalkar, Nikhil

    2017-12-01

    Extra-articular manifestations of rheumatoid arthritis, juvenile idiopathic arthritis, and various spondyloarthritides including psoriatic arthritis, ankylosing spondylitis, reactive arthritis, and inflammatory bowel disease-associated spondyloarthritis often involve the skin and may occur before or after diagnosis of these rheumatic diseases. Cutaneous manifestations encompass a wide range of reactions that may have a notable negative impact not only on the physical but especially on the emotional and psychosocial well-being of these patients. Several cutaneous manifestations have been related to rheumatoid arthritis such as subcutaneous nodules including classical rheumatoid nodules, accelerated rheumatoid nodulosis, and rheumatoid nodulosis; vascular disorders like rheumatoid vasculitis, livedo racemosa, and Raynaud's phenomenon; and neutrophilic and/or granulomatous diseases like pyoderma gangrenosum, Sweet's syndrome, rheumatoid neutrophilic dermatitis, interstitial granulomatous dermatitis with arthritis, as well as palisaded neutrophilic and granulomatous dermatitis. In juvenile idiopathic arthritis, the main cutaneous manifestations include an evanescent rash, rheumatoid nodules, as well as plaque and guttate psoriasis. Plaque psoriasis is also the main skin disease involved in spondyloarthritides. Furthermore, other forms of psoriasis including guttate, inverse, erythrodermic, pustular, and particularly nail psoriasis may also occur. In addition, a variety of drug-induced skin reactions may also appear in these diseases. Early recognition and understanding of these different dermatologic manifestations together with an interdisciplinary approach are often needed to optimize management of these diseases.

  1. Acne conglobata in a long-term survivor with trisomy 13, accompanied by selective IgM deficiency.

    Science.gov (United States)

    Inoue, Chiyoko N; Tanaka, Yoshiko; Tabata, Nobuko

    2017-05-07

    Trisomy 13 (T13) is a congenital chromosomal disorder that is usually fatal within 2 years of birth, and only a few patients have been reported to reach adolescence. Here, we report a male long-term survivor of T13, currently 15 years of age, with a several-year history of extensive acne conglobata (AC) with abscesses on the face and neck. Methicillin-resistant Staphylococcus aureus was consistently isolated from the pustular lesions. Serum IgM levels were extremely low at 10 mg/dl. There were no abnormalities in neutrophil and total B cell number, or in serum IgA and IgG levels. Increased CD8+ T cell counts and inversion of the CD4/CD8 ratio were observed repeatedly. The patient's clinical features and laboratory data support a diagnosis of selective IgM deficiency (SIgMD) with concurrent AC. Immunoglobulin replacement therapy elevated serum IgM levels to the normal range and reduced the severity of AC. We suggest that T13 may represent a syndromic disorder associated with multiple organ malformation and a risk of developing immunodeficiency involving SIgMD. Because pediatric SIgMD is rare and an immunological abnormality in T13 patients has not previously been reported, we describe the patient's clinical course. © 2017 Wiley Periodicals, Inc.

  2. Nocardia yamanashiensis in an immunocompromised patient presenting as an indurated nodule on the dorsal hand.

    Science.gov (United States)

    Anzalone, C Lane; Cohen, Philip R; Tarrand, Jeffrey J; Diwan, Abdul H; Prieto, Victor G

    2013-01-01

    Nocardia are ubiquitous, aerobic, gram-positive actinomycetes. Nocardiosis typically occurs in immunocompromised patients, although immunocompetent individuals can also be affected. The purpose of this case study is to review the clinical characteristics and treatments of a unique form of cutaneous nocardiosis. We retrospectively reviewed the medical literature using PubMed, searching the terms cutaneous, host, immunocompromised, Nocardia, primary, yamanashiensis. Patient reports and previous reviews of the subject were critically assessed and the salient features are presented. Cutaneous nocardiosis typically presents as pustular nodules and the lesions may progress to become abscesses, cellulitis, granulomas or keloid-like tumors. N. brasiliensis is the predominant species involved in primary cutaneous nocardiosis; other common Nocardia species involved in human disease are N. farcinica, N. abscessus, N. cyriacigeorgica, and N. nova. Only two individuals (including the patient presented here) with primary cutaneous infection by N. yamanashiensis have been described in the literature; a third clinical isolate was recovered from a lung biopsy. Nocardia yamanashiensis is a rare clinical form of primary cutaneous nocardiosis. 16S ribosomal gene sequencing, as well as Gram stain and modified Fite acid-fast stain, play a vital role in identifying this clinical variant.

  3. Cutaneous manifestations of Nocardia brasiliensis infection in Taiwan during 2002-2012-clinical studies and molecular typing of pathogen by gyrB and 16S gene sequencing.

    Science.gov (United States)

    Chen, Kuo-Wei; Lu, Chun-Wei; Huang, Ting-Chi; Lu, Chin-Fang; Liau, Yea-Ling; Lin, Jeng-Fong; Li, Shu-Ying

    2013-09-01

    To observe the clinicopathologic and resistance profiles of the Nocardia brasiliensis causing cutaneous nocardiosis in Taiwan, 12 N. brasiliensis isolates were prospectively collected from patients with cutaneous nocardiosis in a hospital during 2002-2012. Clinicopathologic data were obtained, and isolates were identified by biochemical methods and 16S rRNA sequencing. Susceptibilities to 14 antimicrobial compounds were tested. Isolates were further genotyped by sequencing of 16S rRNA, secA1, hsp65, and gyrB genes. The nodulopustular pyoderma associated with sporotrichoid spreading was the most common skin presentations caused by N. brasiliensis. All of the isolates were susceptible to amikacin, gentamicin, tobramycin, piperacillin/tazobactam, and trimethoprim/sulfamethoxazole and resistant to kanamycin, erythromycin, and oxacillin, while susceptibilities to imipenem, vancomycin, penicillin-G, tetracycline, clindamycin, and ciprofloxacin varied among the 12 isolates. GyrB genotyping delineated the 12 isolates into 2 major groups, which was coincident with different single nucleotide substitutions at position 160 (G versus T) of 16S rRNA, different levels of imipenem minimum inhibition concentration (4-32 versus 0.25-0.75 mg/L), and prevalence of lymphadenitis (66.7 versus 16.7%). We have noted that tiny pustular lesions can be the first sign of cutaneous nocardiosis, which we believe has not been previously emphasized. No resistance to trimethoprim and sulfamethoxazole was found; therefore, sulphonamide drugs remain effective for treatment of cutaneous nocardiosis in Taiwan. Copyright © 2013 Elsevier Inc. All rights reserved.

  4. Psoriasis and uveitis: a literature review*

    Science.gov (United States)

    Fraga, Naiara Abreu de Azevedo; de Oliveira, Maria de Fátima Paim; Follador, Ivonise; Rocha, Bruno de Oliveira; Rêgo, Vitória Regina

    2012-01-01

    Psoriasis is a systemic, chronic, immunologically mediated disease, with significant genetic and environmental influences. It affects from 1 to 3% of the world population. Recently, the relation between psoriasis and different comorbidities, particularly metabolic syndrome, has become extremely relevant. Uveitis is characterized by a process of intraocular inflammation resulting from various causes. Considering psoriasis and uveitis as immune-mediated diseases, this study aims to evaluate the possible association of psoriasis and/or psoriatic arthritis with uveitis and its subtypes. Few studies have evaluated the association of uveitis and psoriasis without joint involvement. It seems that psoriasis without arthropathy is not a risk factor for the development of uveitis. Uveitis tends to develop more frequently in patients with arthropathy or pustular psoriasis than in patients with other forms of psoriasis. Ophthalmic examination should be performed periodically in patients with psoriasis and uveitis. If ophthalmopathy is diagnosed, the patient should receive adequate treatment with anti-inflammatory drugs or immunomodulators to prevent vision loss. PMID:23197207

  5. Bacterial infections following non-ablative fractional laser treatment: a case series and discussion.

    Science.gov (United States)

    Xu, Lisa Y; Kilmer, Suzanne L; Ross, E Victor; Avram, Mathew M

    2015-02-01

    Non-ablative fractional laser procedures have become increasingly popular since their introduction in 2004. The fractional 1,927 nm thulium laser is a non-ablative device that penetrates up to 300 μm in the skin and the 1,550 nm erbium:glass laser penetrates up to 1,400 μm. These procedures are considered minimally invasive with a high safety profile; therefore, infectious complications are exceedingly rare. However, we report five recent cases of bacterial infection with both gram-positive and gram-negative organisms following treatment with the fractional 1550/1927 nm laser approximately 1 day to 1 week post-procedure. One patient had a rapidly progressing pustular eruption with symptoms of sepsis. These patients were seen immediately, cultures were obtained and empiric antibiotic therapy was initiated. They recovered without long-term complications. Rapid-onset bacterial infections following non-ablative laser resurfacing with the 1550/1927 nm laser have not been previously reported in the literature. The infections can progress quickly and lead to serious sequelae, including systemic illness and severe scarring, if not identified and appropriately treated. We present these cases to highlight the importance of close surveillance and when appropriate, rapid intervention, following non-ablative fractional procedures, especially when patients present with atypical symptoms and signs. © 2015 Wiley Periodicals, Inc.

  6. Multiple skin ulcers due to Serratia marcescens in a immunocompetent patient.

    Science.gov (United States)

    Carlesimo, M; Pennica, A; Muscianese, M; Bottoni, U; Abruzzese, C; Giubettini, M; Pranteda, G; Pranteda, G

    2014-06-01

    Serratia marcescens is a species of gram negative bacillus, classified as a member of the Enterobacteriaceae, mainly involved in opportunistic infections, particulary in the hospital environment. Cutaneous infections have rarely reported in literature and are predominantly observed in elderly or in immunocompromised patients. The clinical manifestations of skin infections include granulomatous lesions, necrotizing fasciitis, nodules, cellulitis, ulcers, dermal abscesses. Infections caused by S. marcescens may be difficult to treat because of resistance to a variety of antibiotics, including ampicillin and first and second generation cephalosporins. Aminoglycosides have good activity against S. marcescens, but resistant strains have also been described. We report a very intriguing case of S. marcescens infection, in an immunocompetent 18-year-old man, causing multiple rounded ulcers of varying sizes, along with few pustular lesions that both clinically and histopathologically mimic a pyoderma gangrenosum (PG). This is a non infectious neutrophilic skin disorder, characterized by painful and rapidly progressing skin ulceration. According to our experience, we would strongly recommend to perform cultures of multiple skin ulcers resembling PG, even in young healthy patients, to ensure correct diagnosis and treatment, since resistant to conventional antibiotics bacteria such as S. marcescens may be the cause of these lesions, like in the case here reported.

  7. [Blasch-kolinear psoriasis revealed by infliximab therapy].

    Science.gov (United States)

    Sfia, M; Roth-Mall, B; Tortel, M-C; Guillaume, J-C; Cribier, B

    2009-12-01

    Blaschko-linear psoriasis is a rare disease about which only a few publications have appeared in the literature. This form of psoriasis poses problems of differential diagnosis with regard to other forms of inflammatory Blaschko-linear dermatoses. Herein, we report an original case, the linear nature of which was revealed by treatment with infliximab. A 29-year-old man presented chronic psoriasis present for 17 years and resistant to various forms of systemic therapy. Treatment with infliximab 5mg/kg given on D1, D15 and two-monthly, thereafter resulted in practically complete resolution of all skin lesions after the fourth infusion. The only remaining lesions were psoriatic erythematous-squamous, non-pustular lesions with a Blaschko-linear pattern, limited to one side, on the left arm and left leg. These lesions persisted after 10 courses of infliximab, although no other lesions reappeared. This case was original in terms of the revelation of Blaschko-linear lesions during treatment with infliximab, despite the complete disappearance of diffuse psoriatic plaques, thus suggesting the existence in this patient of two cell populations, each having a different response to biotherapy.

  8. Adverse cutaneous reactions to epidermal growth factor receptor inhibitors: a study of 14 patients.

    Science.gov (United States)

    Santiago, Felicidade; Gonçalo, Margarida; Reis, José Pedro; Figueiredo, Américo

    2011-01-01

    Cetuximab and erlotinib, epidermal growth factor receptor inhibitors, often cause peculiar adverse cutaneous reactions. Our aim was to evaluate adverse cutaneous reactions and their management in patients undergoing treatment with cetuximab and erlotinib. Between March/2005 and September/2009, we observed 14 patients with a mean age of 59.6 years undergoing treatment with cetuximab (7) or erlotinib (7), due to lung(10) or colorectal cancer (4). We evaluated the interval between introduction of the drug and onset of symptoms, treatment response, and the clinical pattern of evolution of the cutaneous reaction retrospectively. Twelve patients presented papular-pustular eruption typically affecting the face, chest and back, which appeared in average 13.5 days after starting the drug treatment. The patients underwent oral treatment with minocycline or doxycycline and topical treatment with metronidazole, benzoyl peroxide and/or corticosteroids. All patients showed improvement of the lesions. Five patients presented periungual pyogenic granulomas, which were associated with paronychia in 4 cases, after an average of 8 weeks of treatment. There was improvement of the lesions with topical treatment (antibiotics, corticosteroids and antiseptics). Xerosis was observed in some patients. Other less frequent adverse side effects such as telangiectasia and angiomas, hair and eyelash alterations, and eruptive melanocytic nevi were also described. Treatment with epidermal growth factor receptor inhibitor was maintained in most patients. The increasing use of these targeted therapies requires knowledge of their adverse cutaneous side effects to ensure timely intervention in order to allow the continuation of the therapy.

  9. Molecular Genetic Analysis of Orf Virus: A Poxvirus That Has Adapted to Skin

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    Stephen B. Fleming

    2015-03-01

    Full Text Available Orf virus is the type species of the Parapoxvirus genus of the family Poxviridae. It induces acute pustular skin lesions in sheep and goats and is transmissible to humans. The genome is G+C rich, 138 kbp and encodes 132 genes. It shares many essential genes with vaccinia virus that are required for survival but encodes a number of unique factors that allow it to replicate in the highly specific immune environment of skin. Phylogenetic analysis suggests that both viral interleukin-10 and vascular endothelial growth factor genes have been “captured” from their host during the evolution of the parapoxviruses. Genes such as a chemokine binding protein and a protein that binds granulocyte-macrophage colony-stimulating factor and interleukin-2 appear to have evolved from a common poxvirus ancestral gene while three parapoxvirus nuclear factor (NF-κB signalling pathway inhibitors have no homology to other known NF-κB inhibitors. A homologue of an anaphase-promoting complex subunit that is believed to manipulate the cell cycle and enhance viral DNA synthesis appears to be a specific adaptation for viral-replication in keratinocytes. The review focuses on the unique genes of orf virus, discusses their evolutionary origins and their role in allowing viral-replication in the skin epidermis.

  10. Sporotrichosis Mimicking Cellulitis

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    Gul Karagoz

    2016-09-01

    Full Text Available Sporotrichosis is a cutaneous or systemic fungal infection caused by Sporothrix schenckii. The infection is characterized by nodular, pustular, or ulcerative lesions. Infection usually occurs after traumatic implantation of the fungus into the skin. We report a case presenting first cellulitis and later on as a non-healing ulcer which was diagnosed by punch biopsy as sporotrichosis and managed successfully with itraconazole. A 56-year-old woman admitted to our department with complaint acute onset of swelling of the right lower-extremity with erythema and warmth. The patient was diagnosed initially as celulitis and started on ampicillin-sulbactam. Diagnosis of sporotrichosis was made with histological examination skin biopsy and the patient was started on itraconazole. One month after commencement of antifungal treatment, the ulcer began to dry up and at 3 months the lesions had healed. This case shows that if a wound do not respond to antibiotics in cases with ulcer, some rare etiological agents should be considered. [Dis Mol Med 2016; 4(3.000: 34-36

  11. Chapter 28: Classification of hypersensitivity reactions.

    Science.gov (United States)

    Uzzaman, Ashraf; Cho, Seong H

    2012-01-01

    The original Gell and Coomb's classification categorizes hypersensitivity reactions into four subtypes according to the type of immune response and the effector mechanism responsible for cell and tissue injury: type I, immediate or IgE mediated; type II, cytotoxic or IgG/IgM mediated; type III, IgG/IgM immune complex mediated; and type IV, delayed-type hypersensitivity or T-cell mediated. The classification has been improved so that type IIa is the former type II and type IIb is antibody-mediated cell stimulating (Graves Disease and the "autoimmune" type of chronic idiopathic urticaria). Type IV has four major categories: type IVa is CD4(+)Th1 lymphocyte mediated with activation of macrophages (granuloma formation and type I diabetes mellitus); type IVb is CD4(+)Th2 lymphocyte mediated with eosinophilic involvement (persistent asthma and allergic rhinitis); type IVc is cytotoxic CD8(+) T lymphocyte with involvement of perforin-granzme B in apoptosis (Stevens-Johnson syndrome and toxic epidermal necrolysis); type IVd is T-lymphocyte-driven neutrophilic inflammation (pustular psoriasis and acute generalized exanthematous pustulosis). Some diseases have multiple types of immunologic hypersensitivity.

  12. Orf virus interferes with MHC class I surface expression by targeting vesicular transport and Golgi

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    Rohde Jörg

    2012-07-01

    Full Text Available Abstract Background The Orf virus (ORFV, a zoonotic Parapoxvirus, causes pustular skin lesions in small ruminants (goat and sheep. Intriguingly, ORFV can repeatedly infect its host, despite the induction of a specific immunity. These immune modulating and immune evading properties are still unexplained. Results Here, we describe that ORFV infection of permissive cells impairs the intracellular transport of MHC class I molecules (MHC I as a result of structural disruption and fragmentation of the Golgi apparatus. Depending on the duration of infection, we observed a pronounced co-localization of MHC I and COP-I vesicular structures as well as a reduction of MHC I surface expression of up to 50%. These subversion processes are associated with early ORFV gene expression and are accompanied by disturbed carbohydrate trimming of post-ER MHC I. The MHC I population remaining on the cell surface shows an extended half-life, an effect that might be partially controlled also by late ORFV genes. Conclusions The presented data demonstrate that ORFV down-regulates MHC I surface expression in infected cells by targeting the late vesicular export machinery and the structure and function of the Golgi apparatus, which might aid to escape cellular immune recognition.

  13. Acne vulgaris: prevalence and clinical forms in adolescents from São Paulo, Brazil*

    Science.gov (United States)

    Bagatin, Ediléia; Timpano, Denise Lourenço; Guadanhim, Lilia Ramos dos Santos; Nogueira, Vanessa Mussupapo Andraus; Terzian, Luiz Roberto; Steiner, Denise; Florez, Mercedes

    2014-01-01

    BACKGROUND Acne is a common disease in adolescents, but there are no epidemiological data for acne in Brazil. OBJECTIVES To estimate the prevalence and degree of acne in adolescents from Sao Paulo and study socio-demographic factors, family history and lifestyle, associated with the disease. METHODS Cross-sectional study with 452 adolescents aged between 10 and 17 (mean=13.3 years), students from elementary and high school, examined by 3 independent evaluators. RESULTS 62.4% were female, 85.8% white and 6.4% were aged 14. The prevalence was 96.0% and increased with age - all students over 14 had acne. The most prevalent form of acne was comedonal (61.1%), followed by mild (30.6%) and moderate (7.6%) papular-pustular, which affected mostly the face (97.5%). About half of the adolescents reported family history for acne in mother or father, and 20.6% reported previous treatment for acne. There was a higher chance of presenting non-comedonal acne with increased age (pacne in adolescents varies widely due to the clinical features and diagnostic methods used. Adolescents whose brothers/sisters had acne (OR=1.7-p=0.027) and those over 13 (OR=8.3-pacne. CONCLUSION This study showed high prevalence of acne in adolescents from Sao Paulo, predominantly the comedonal form on the face, with a higher chance of presenting non-comedonal acne with increased age. PMID:24937816

  14. Genetic heterogeneity in psoriasis vulgaris based on linkage analyses of a large family material

    Energy Technology Data Exchange (ETDEWEB)

    Wahlstroem, J.; Swanbeck, G.; Inerot, A. [ Univ. of Goeteborg (Sweden)] [and others

    1994-09-01

    Information on psoriasis among parents and siblings in 14,008 families has been collected. On the basis of this material, evidence for monogenetic autosomal recessive inheritance of psoriasis has recently been presented. Indications from more than one type of non-pustular psoriasis has been obtained from the population genetic data. Molecular genetic linkage analysis of psoriasis to a number of polymorphic genetic markers for a large number of families has been made. It is apparent that there is genetic heterogeneity in a psoriasis population with regard to psoriasis genes. Using the computer program Linkage 5.0 and a formula for heterogeneity, a lodscore over 3.0 for one locus has been obtained. This locus has further been confirmed by several other markers in the vicinity. The locus found is linked to slightly over half of the families, indicating that there are more genetically independent types of psoriasis. The age at onset of those families that are apparently linked to this locus have a slightly higher age at onset than those not linked to that locus but with a considerable overlap. In spite of close coverage of the whole chromosomes number 6 and 17, no linkage has been found in this regions. This indicates that neither the HLA region nor the region earlier found to be involved in one family with psoriasis are primarily involved in our families.

  15. Cutaneous manifestations of adult-onset Still's disease: a case report and review of literature.

    Science.gov (United States)

    Cozzi, Alessandra; Papagrigoraki, Anastasia; Biasi, Domenico; Colato, Chiara; Girolomoni, Giampiero

    2016-05-01

    Adult onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown etiology and pathogenesis characterized by high spiking fever, arthralgia or arthritis, sore throat, lymphadenopathy, hepatosplenomegaly, serositis, and transient cutaneous manifestations. Although more common in children, cases are seen also in adults. Cutaneous involvement is common and may be suggestive for the diagnosis. A case of AOSD in a 35-year-old man is reported here, presenting with urticarial maculopapular rash of trunk, high spiking fever, acute respiratory distress syndrome, and myopericarditis. Skin biopsy showed interstitial and perivascular mature CD15(+) neutrophils. A comprehensive review of literature showed that cutaneous involvement occurs in about 80 % of patients, with various clinical presentations. The most common skin manifestation is an evanescent salmon pink or erythematous maculopapular exanthema, predominantly on the trunk and proximal limbs, with rare involvement of face and distal limbs. Less common manifestations include persistent erythematous plaques and pustular lesions. A constant histopathologic finding is the presence of interstitial dermal neutrophils aligned between the collagen bundles. This pattern may provide an easy accessible clue for the definitive diagnosis of AOSD and exclude other diagnosis such as drug eruptions or infectious diseases.

  16. Immunohistopathological Findings of Severe Cutaneous Adverse Drug Reactions

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    Mari Orime

    2017-01-01

    Full Text Available Diagnosis of severe cutaneous adverse drug reactions should involve immunohistopathological examination, which gives insight into the pathomechanisms of these disorders. The characteristic histological findings of erythema multiforme (EM, Stevens–Johnson syndrome (SJS, and toxic epidermal necrolysis (TEN provide conclusive evidence demonstrating that SJS/TEN can be distinguished from EM. Established SJS/TEN shows full-thickness, extensive keratinocyte necrosis that develops into subepidermal bullae. Drug-induced hypersensitivity syndrome (DIHS and exanthema in drug reaction with eosinophilia and systemic symptoms (DRESS each display a variety of histopathological findings, which may partly correlate with the clinical manifestations. Although the histopathology of DRESS is nonspecific, the association of two or more of the four patterns—eczematous changes, interface dermatitis, acute generalized exanthematous pustulosis- (AGEP- like patterns, and EM-like patterns—might appear in a single biopsy specimen, suggesting the diagnosis and severe cutaneous manifestations of DRESS. Cutaneous dendritic cells may be involved in the clinical course. AGEP typically shows spongiform superficial epidermal pustules accompanied with edema of the papillary dermis and abundant mixed perivascular infiltrates. Mutations in IL36RN may have a definite effect on pathological similarities between AGEP and generalized pustular psoriasis.

  17. Crohn's disease and Sweet's syndrome: an uncommon association Enfermedad de Crohn y síndrome de Sweet: una asociación infrecuente

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    I. Catalán-Serra

    2010-05-01

    Full Text Available Sweet's syndrome or acute febrile neutrophilic dermatosis (SS is characterized by the sudden onset of painful erythematous lesions (papules, nodules, and plaques together with fever and neutrophilia. The lesions are typically located on hands, arms, upper trunk, neck and face, showing an asymmetric distribution. Acute phase reactants are usually elevated and dermal infiltration of neutrophils without vasculitis is seen on skin biopsies. It is considered as a marker of systemic disease in over half of the cases, and is associated with infections, inflammatory bowel disease, autoimmune connective tissue disorders and various neoplasias. Its association with Crohn's disease (CD is unusual and it appears mainly in association with colonic involvement. Fewer than 50 cases have been published in the medical literature since its first description in 1964, some concurrent with the first episode of CD. We present two patients with Crohn's disease and Sweet's syndrome diagnosed in our department at the time of CD diagnosis, as well as their response to treatment, subsequent course of the disease, and a review of the scientific literature.El síndrome de Sweet o dermatosis neutrofílica febril aguda (SS se caracteriza por la aparición brusca de lesiones eritematosas, (pápulas, nódulos y placas dolorosas, junto con fiebre y neutrofilia, siendo de presentación poco frecuente. Las lesiones se localizan preferentemente en manos, brazos, parte superior del tronco, cuello y cara, con distribución asimétrica. Suele haber elevación de reactantes de fase aguda y en las biopsias cutáneas se identifica una infiltración dérmica de neutrófilos sin vasculitis. Se considera un marcador de enfermedad sistémica en más de la mitad de los casos, asociándose a infecciones, enfermedad inflamatoria intestinal, conectivopatías autoinmunes y diversas neoplasias. Su asociación con la enfermedad de Crohn (EC es poco habitual, asociado sobre todo a afectación col

  18. Patología laboral sensibilizante, respiratoria y cutánea en la industria alimentaria

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    Karly Paola Cedeño Gabriel

    2014-09-01

    Full Text Available La introducción de nuevas sustancias en la industria alimentaria ocasiona nuevas "sensibilizaciones" a multitud de productos como son materias primas de aditivos alimentarios y productos intermedios. Existen factores tanto individuales (atopía, tabaquismo, rinitis como industriales (niveles de exposición, poder de sensibilización de los alérgenos, "trabajo húmedo" asociados a un mayor riesgo de presentación de asma y dermatitis de contacto ocupacional (irritativa y alérgica. La importancia desde el punto de vista del número de casos notificados, hace necesario profundizar en el conocimiento y evidencia científica existente en cuanto a la epidemiologia e historia natural de la enfermedad profesional por hipersensibilidad. Con el objetivo de determinar la evidencia científica existente sobre la asociación entre las condiciones de trabajo y las enfermedades pulmonares y dermatosis en la industria alimentaria, se realizó un análisis sistemático de la producción científica identificada entre 2007-2012, en las principales bases de datos bibliográficas: PubMed, Scielo, Embase, Scopus, Lilacs, www.ilo.org/cisdocdatabase. Un total de 23 artículos cumplieron los criterios de inclusión. Los resultados permiten concluir que la prevalencia por hipersensibilidad varia en función de la actividad y del agente sensibilizante entre 7% y un 38,7% con un nivel de evidencia entre 2 ++ y 3. Dentro de las dermatosis ocupacionales, la dermatitis de contacto irritativa sigue siendo más prevalente que la dermatitis de contacto alérgica. La dermatitis de contacto proteínica es un trastorno frecuente en manipuladores de alimentos y debe considerarse una entidad clínica aparte. La atopía es un factor de riesgo para el desarrollo de clínica respiratoria y cutánea. No se identificaron en la literatura nuevos test diagnósticos.

  19. Psoriasis and sport: a new ally?

    Science.gov (United States)

    Balato, N; Megna, M; Palmisano, F; Patruno, C; Napolitano, M; Scalvenzi, M; Ayala, F

    2015-03-01

    Psoriasis is a common chronic multifactorial disease which can result in restrictions to social and recreational activities. Psoriasis subjects are at high risk to develop metabolic and cardiovascular diseases. Physical activity, a vital component in prevention and management of these diseases, is reported to be potentially associated in a negative way with psoriasis. To investigate the relationship between psoriasis and physical activity. Anamnestic and physical examination as well as a specific doctor-administered questionnaire was performed to a group of 416 consecutive sportive subjects and 489 sex and age-matched controls. Moreover, similar investigations were executed on 400 consecutive psoriatic patients without psoriatic arthritis. Psoriasis was significantly more common in controls respect to sportive group (n = 27, 5.4% vs. n = 7, 1.7%, P history of psoriasis was observed in similar percentages in both groups (n = 51, 10.2% vs. n = 40, 9.6%). The number of subjects performing sports activities was significantly lower in psoriasis group compared to controls (n = 44, 11% vs. n = 106, 21.3%; P sporting activities showed a positive influence on the natural course of their disease, whereas the remaining 11 patients did not highlight positive or negative influences on their illness. Interestingly, 23.75% of psoriatic patients (n = 95) related that they had regularly carried out sporting activities before the onset of the dermatosis referring that psoriasis represented a huge obstacle to continue practicing physical activities. Our survey showed that regular physical activity may lower the risk of psoriasis and have a beneficial effect on the natural course of the disease, positively influencing not only the severity as well as the incidence of metabolic comorbidities, but also, through possible epigenomic, metabolic, anti-inflammatory and psycho-emotional effects, the onset of the dermatosis. However, larger birth cohort studies are needed to

  20. Rinossinusite em paciente com síndrome de Behçet Rhinosinusitis in a patient with Behçet's syndrome

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    Lauro João Lobo Alcântara

    2005-04-01

    Full Text Available A condição conhecida como Síndrome de Behçet foi inicialmente descrita por H. Behçet, um dermatologista turco. O seu componente principal são lesões aftosas recorrentes em mucosa oral. Grupos como os asiáticos são mais propícios ao seu desenvolvimento. No continente americano, ela é relativamente rara. Além de lesões orais, os pacientes podem desenvolver ulcerações genitais, uveítes, vasculite pustular da pele, sinovites e meningoencefalites. O diagnóstico é baseado na pronunciação de critérios maiores e/ou menores internacionalmente propostos, e na combinação entre eles. O tratamento é desafiador, devendo dirigir-se ao principal órgão envolvido, exigindo terapias combinadas com freqüência. O quadro clínico do paciente deste caso não deixa dúvidas quanto ao diagnóstico da síndrome de Behçet. No presente trabalho, a vasculite é evidenciada pela ausência de sangramento ao manueseio de áreas potencialmente sangrantes. E a ela atribuiu-se tanto o desencadeamento quanto as complicações da rinossinusite (abscesso periorbitário, haja visto seus efeitos de má perfusão e drenagem no tecido em questão. A rinossinusite é uma manifestação potencial da síndrome de Behçet. Os profissionais médicos devem estar atentos à sua apresentação e prestar maiores cuidados para sua resolução, que é caracteristicamente difícil.The condition known as Behçet's syndrome was first described by H. Behçet, a dermatologist from Turkey. Its major component is recurrent aphthous-like lesions of the oral mucosa. Some groups of people such as the Japanese are more prone to develop the condition. Behçet's syndrome is relatively rare in the American continent. In addition to oral lesions, these patients may develop recurrent genital ulcerations, uveitis, and pustular vasculitis of the skin, synovitis, and meningoencephalitis. The diagnosis is based on occurrence of internationally proposed major or/and minor criteria and on