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Sample records for suan shu shu

  1. Proof and Pedagogy in Ancient China: Examples from Liu Hui's Commentary on "JIU ZHANG SUAN SHU".

    Science.gov (United States)

    Siu, Man-Keung

    1993-01-01

    Illustrates the pedagogical implications embodied in Liu Hui's discussion on the ancient Chinese mathematical classic "JIU ZHANG SUAN SHU" (Nine Chapters on the Mathematical Art) with respect to aspects of proof and, more generally, the role of proof in mathematics. Provides examples involving area and volume. (Contains 25 references.)…

  2. Luo Shu

    Directory of Open Access Journals (Sweden)

    Albert Ting Pat So

    2015-05-01

    Full Text Available Feng Shui, still popularly practiced today, was closely related to philosophy, natural science, geography, environmental science, architecture, metaphysics, and astrology in ancient China. It is basically divided into the Form School and the Compass School. The latter deals with numerology, calculation, orientation, and time. Luo Shu [洛書], associated with the eight trigrams [八卦], being an ancient Chinese magic square, forms the foundation of the Compass School. The original Luo Shu, a 3 × 3 magic square, was not unique in ancient China but the extension of it to a total of 18 to 36 standard charts was unique, which are still used by all Compass School Feng Shui masters. In this article, modern linear algebra, developed only in the mid-19th century, is employed to prove that there is a strong coherence between the 36 charts if they are treated as 36 matrices and such correspondences conscientiously agree with ancient theories of Feng Shui. This article may help to form a scientific base for the systematic understanding, development, and further research of Luo Shu–related applications.

  3. [Further textual research on Shang shu quan shu (A Complete Book of Summer-heat Diseases) and Zeng ding shang shu quan shu (Revised and Expanded: A Complete Book of Summer-heat Disease)].

    Science.gov (United States)

    Xiao, Yong-zhi; Huang, Qi-xia

    2010-07-01

    Zhang Heteng's Shang shu quan shu of the Ming Dynasty and Ye Lin's Zeng ding shang shu quan shu of the Qing Dynasty are two significant books on warm diseases. By research into the author and the editor of both books, the process of its writing, the academic origin and evolution of its versions, it is found that there are errors concerning the date of writing, evolution of its number of volumes, and changes of versions found in the National United Catalogues of TCM Books and the General Catalogues of Chinese Ancient Medical Books which are subject to correction.

  4. Shu proteins promote the formation of homologous recombination intermediates that are processed by Sgs1-Rmi1-Top3

    DEFF Research Database (Denmark)

    Mankouri, Hocine W; Ngo, Hien-Ping; Hickson, Ian D

    2007-01-01

    CSM2, PSY3, SHU1, and SHU2 (collectively referred to as the SHU genes) were identified in Saccharomyces cerevisiae as four genes in the same epistasis group that suppress various sgs1 and top3 mutant phenotypes when mutated. Although the SHU genes have been implicated in homologous recombination ...

  5. Jing Tong Yu Shu , a traditional Chinese medicine, suppresses IL ...

    African Journals Online (AJOL)

    Purpose: To evaluate the effect of a traditional Chinese medicine, Jing Tong Yu Shu (JTYS) on endometriosis in a rat surgical model. Methods: Endometriosis was induced in 40 female rats. The rats were randomly divided into 4 groups: three JTYS groups given different doses of the drug, and a saline group. After four ...

  6. Investigation of the Effect of the Degree of Processing of Radix Rehmanniae Preparata (Shu Dihuang on Shu Dihuangtan Carbonization Preparation Technology

    Directory of Open Access Journals (Sweden)

    Xianglong Meng

    2017-07-01

    Full Text Available Carbonization of Radix Rehmanniae Preparata (Shu Dihuangtan via stir-frying could increase its homeostasis maintaining and antidiarrheal effects. To ensure these pharmacological functions, the quality of the raw material (processed Rehmanniae Radix must be well controlled. Therefore, we analyzed the effects of different degrees of processing and adjuvants on processed Rehmanniae Radix (Shu Dihuang by High Performance Liquid Chromatography (HPLC chromatographic fingerprints, thermal gravimetric analysis and Fourier transform infrared spectroscopy (FTIR. Based on the results from HPLC fingerprints combined with similarity analysis (SA and hierarchical cluster analysis (HCA the optimum processing method for Shu Dihuang was five cycles of steaming and polishing, which follows the ancient processing theory. The intensity of thermal weight loss rate peaked near 210.33 ± 4.32 °C or 211.33 ± 2.62 °C, which was an important indicator for the degree of processing of Shu Dihuang. A temperature near 290.89 ± 2.51 °C was the upper limit for carbonizing Shu Dihuangtan. FTIR spectroscopy analysis showed that the overall chemical composition of Shu Dihuangtan was affected by both the degree of processing and adjuvant, which are very important for its quality.

  7. [Autobiography of modern acupuncturist Yu Shu-zhuang].

    Science.gov (United States)

    Li, Jia-jian' i; Guo, Jing; Yu, Zhen-zhong; Wang, Lin-peng

    2014-11-01

    Professor YU Shu-zhuang is a distinguished acupuncturist in China. He has practiced the TCM acupuncture-moxibustion clinical, educational and scientific research for 60 years in his life. In clinic, he summarized the experiences "five-ming first"; in treatment, he insisted "dredging" and "regulating", protecting the function of spleen and stomach, and needles should be less but specific. In the meanwhile, he made a deep study on the function and clinical effects of specific acupoints, and used the research results of propagated sensation along channel to guide clinical treatment, forming his special academic points. Professor YU has educated a great number of acupuncture-moxibustion talents in China and foreign countries, making great contribution to the popularization of acupuncture-moxibustion in the worldwide.

  8. Jing Tong Yu Shu, a traditional Chinese medicine, suppresses IL-1β ...

    African Journals Online (AJOL)

    Zhang et al. 2953. Tropical ... Purpose: To evaluate the effect of a traditional Chinese medicine, Jing Tong Yu Shu (JTYS) on endometriosis in a ..... Flower A, Liu JP, Chen S, Lewith G, Little P. Chinese ... Mol Hum Reprod 2000; 6: 269-275. 18.

  9. Shu shu 數術: When an actor’s category became an observer’s category, why, and what we can do about it

    OpenAIRE

    Morgan , Daniel Patrick

    2016-01-01

    International audience; Shu shu (lit. ‘numbers & procedures’), as it appears in Asian- and Western-language sinology alike, is a modern academic field that has arisen since 1993 around excavated divinatory and magico-religious manuscripts, primarily clustered in the fourth to second century BCE. The term itself originates from early bibliographic classification, circa 26 BCE – 92 CE, which placed the astral and mathematical sciences (tianwen 天文 ‘heaven’s form’ omenology, li 曆 mathematical ast...

  10. The SHU Social Media CoLab: developing a social media strategy through open dialogue and collaborative guidance

    OpenAIRE

    Beckingham, Sue; Purvis, Alison; Rodger, Helen

    2014-01-01

    This paper shares the strategy we have developed at Sheffield Hallam University (SHU) to educate and guide staff and students in their use of social media. Students need to understand their responsibilities to themselves and the institution, to develop sustainable strategies for using social media to enhance their learning and to develop their employability skills as future graduates. They need to place value in the development of a professional online presence, appreciate the difference betw...

  11. Dynamic MR imaging of liver lesions with superparamagnetic iron oxide (SH-U-555A)

    International Nuclear Information System (INIS)

    Saito, Kazuhiro; Ishida, Jiro; Ito, Naoki; Kakizaki, Dai; Abe, Kimihiko; Kotake, Fumio

    2001-01-01

    Dynamic MRI with SH-U-555 (SPIO) was evaluated. Dynamic MRI was performed for 17 patients with 22 lesions. Dynamic study with T2 * -weighted imaging (T2 * dynamic) and T1-weighted imaging (T1 dynamic) were performed in 8 cases (10 lesions) and 9 cases (12 lesion), respectively. T2 * dynamic MR images were obtained before and 30, 90, 180, 270, 360, and 450 seconds and 31 minutes after the intravenous injection of SPIO, and T1 dynamic MR images were obtained before and 0, 40, 80, 120, 180, 240, 300, 360, 420, 480 seconds and 28 minutes after the injection of SPIO. The signal intensity of each lesion was measured before and after the injection of SPIO. The enhancement ratio of the lesions was calculated and evaluated. The enhancement ratio of hypervascular lesions decreased rapidly in the first phase of T2 * dynamic MRI, while that of hypovascular lesions decreased gradually. The enhancement ratio of hypervascular lesions increased in the first phase of T1 dynamic MRI and decreased gradually, while that of hypovascular lesions lacked the increase in the first phase, in contrast to hypervascular lesions. However, the changing of signal intensity could not be recognized on images with T2 * dynamic and T1 dynamic study. In conclusion, quantitative analysis using the enhancement ratio made it possible to anticipate lesion vascularity. (author)

  12. Treatment of depression with Chai Hu Shu Gan San: a systematic review and meta-analysis of 42 randomized controlled trials.

    Science.gov (United States)

    Sun, Yan; Xu, Xia; Zhang, Jinping; Chen, Yuanyuan

    2018-02-17

    Depression is a common mental disorder. Chai Hu Shu Gan San, a traditional Chinese medicine, is used to treat depression empirically. We present a systematic review and meta-analysis of the therapeutic efficacy and safety of Chai Hu Shu Gan San in treating depression. Several databases, including PubMed, China National Knowledge Internet, Wanfang, Chongqing VIP, and the Cochrane library, were systematically searched from their date of foundation to January 1, 2017. In this review, wehave included randomized control trials that compared Chai Hu Shu Gan San (or its combination with a regular Western medicine) with a regular Western medicine alone for the treatment of depression. Two investigators independently extracted and analyzed the data using RevMan 5.2.0 software. Mean difference (with a 95% confidence interval) was used as efficacy indices for outcomes. We included 42 studies involving 3234 patients with depression in 15 different types of diseases. Meta analyses showed better effect of Chai Hu Shu Gan San than fluoxetine for pure depression (MD = - 1.59, from - 2.82 to - 0.37, 4 trials, I 2  = 26%), for post-stroke depression (MD = - 4.20, from - 6.20 to - 2.19, 7 trials, I 2  = 96%), and for postpartum depression (MD = - 4.10, from - 7.48 to - 0.72 7 trials, I 2  = 86%). None of the articles reported severe adverse events of oral administration of Chai Hu Shu Gan San. Furthermore, any adverse effects of using Chai Hu Shu Gan San alone were fewer than those of regular Western medicines. This review found that Chai Hu Shu Gan San has some advantages in treating depression, especially post-stroke depression and post-partum depression. A meticulously designed and conducted randomized control trial is needed for further evaluation.

  13. Assessment of the main natural radionuclides, minor and trace elements in soils and sediments of the Shu valley (near the border of Kazakhstan and Kyrgyzstan)

    International Nuclear Information System (INIS)

    Matveyeva, I.; Burkitbayev, M.; Jacimovic, R.; Planinsek, P.; Smodis, B.; Stegnar, P.

    2014-01-01

    New data on the concentrations of the main gamma-emitting radionuclides, minor and trace elements, and isotopes of uranium (with Ra-226 as a daughter product of U-238) and thorium in soils and sediments of the Shu valley (from the river Chon-Kemin to the river Kuragatty downstream the river Shu) are presented, determined by high-resolution gamma-spectrometry, k 0 -instrumental neutron activation analysis and alpha-spectrometry with appropriate radiochemical separations of the samples, respectively. The results obtained showed an aquatic migration pathway of most of the trace elements and radionuclides and predicted water pollution downstream the river Shu. The scandium method showed pollution by As, Br, Ca, Cr, Zr of the Tasotkel dam impoundment and by Ca and Cr of the river Shu below its confluence with the river Kuragatty. According to the disequilibrium isotopic method for uranium (using the isotopic ratio U-234/U-238), areas with accumulation and leaching processes were estimated for soils and sediments of the river Shu and its main inflows. (author)

  14. Expression, purification, crystallization and preliminary X-ray diffraction analysis of the TonB-dependent haem outer membrane transporter ShuA from Shigella dysenteriae

    International Nuclear Information System (INIS)

    Brillet, Karl; Meksem, Ahmed; Thompson, Andrew; Cobessi, David

    2009-01-01

    ShuA from S. dysenteriae was crystallized in several crystallization conditions containing detergents. Adding heavy atoms during crystallization strongly improved the crystal quality and the resolution limits. Diffraction data were collected at an energy remote from the Pb M absorption edges. As part of efforts towards understanding the crystallization of membrane proteins and membrane transport across the outer membrane of Gram-negative bacteria, the TonB-dependent haem outer membrane transporter ShuA of Shigella dysenteriae bound to heavy atoms was crystallized in several crystallization conditions using detergents. The insertion of a His 6 tag into an extracellular loop of ShuA, instead of downstream of the Escherichia coli peptide signal, allowed efficient targeting to the outer membrane and the rapid preparation of crystallizable protein. Crystals diffracting X-rays beyond 3.5 Å resolution were obtained by co-crystallizing ShuA with useful heavy atoms for phasing (Eu, Tb, Pb) by the MAD method at the synchrotron, and the SAD or SIRAS method at the Cu wavelength. The authors collected X-ray diffraction data at 2.3 Å resolution using one crystal of ShuA-Pb, and at 3.2 Å resolution at an energy remote from the Pb M absorption edges for phasing on PROXIMA-1 at SOLEIL

  15. Uptake of uranium, thorium and radium isotopes by plants growing in dam impoundment Tasotkel and the Lower Shu region (Kazakhstan)

    Energy Technology Data Exchange (ETDEWEB)

    Matveyeva, Ilona; Burkitbayev, Mukhambetkali [al-Farabi Kazakh National University, Almaty (Kazakhstan). Faculty of Chemistry and Chemical Technology; Jacimovic, Radojko [Jozef Stefan Institute, Ljubljana (Slovenia). Dept. of Environmental Sciences; Planinsek, Petra; Smodis, Borut [Jozef Stefan Institute, Ljubljana (Slovenia). Dept. of Environmental Sciences; Jozef Stefan International Postgraduate School, Ljubljana (Slovenia)

    2016-04-01

    The activity concentrations of isotopes of uranium, thorium and radium-226 in dominant species of plants (Xantium strumarium, Phragmites communis, Artemisia nitrosa and Artemisia serotina) growing on the territories contaminated by uranium industry of Kazakhstan (close to dam impoundment Tasotkel and the Lower Shu region) are presented. The obtained data showed the significant variations of activity concentrations of isotopes of uranium, thorium and radium-226 in above ground parts. The concentrations of most of the investigated radionuclides in the root system are higher than in the aboveground parts; it can be explained by root barrier. It was found that the highest root barrier has Xantium strumarium, especially for uranium isotopes. The concentration ratios of radionuclides were calculated, and as the result it was found that the highest accumulation ability in the investigated region has Artemisia serotina.

  16. Uptake of uranium, thorium and radium isotopes by plants growing in dam impoundment Tasotkel and the Lower Shu region (Kazakhstan)

    International Nuclear Information System (INIS)

    Matveyeva, Ilona; Burkitbayev, Mukhambetkali

    2016-01-01

    The activity concentrations of isotopes of uranium, thorium and radium-226 in dominant species of plants (Xantium strumarium, Phragmites communis, Artemisia nitrosa and Artemisia serotina) growing on the territories contaminated by uranium industry of Kazakhstan (close to dam impoundment Tasotkel and the Lower Shu region) are presented. The obtained data showed the significant variations of activity concentrations of isotopes of uranium, thorium and radium-226 in above ground parts. The concentrations of most of the investigated radionuclides in the root system are higher than in the aboveground parts; it can be explained by root barrier. It was found that the highest root barrier has Xantium strumarium, especially for uranium isotopes. The concentration ratios of radionuclides were calculated, and as the result it was found that the highest accumulation ability in the investigated region has Artemisia serotina.

  17. 浅析豫东琴书中所用乐器%A Brief Analysis of Instruments Used in Eastern QinShu

    Institute of Scientific and Technical Information of China (English)

    吉莉

    2014-01-01

    介绍了豫东琴书及其表演中所用的乐器,并详细分析了其中几件乐器在外观、演奏手法及声音等方面的异同。%The instrument used in performance of eastern QinShu is introduced, and the similarities and differences of several instruments in the aspects of appearance, playing style and voice were analysed.

  18. The coastline remote sensing survey for Zhao Shu Island in Xisha Islands based on WorldView-2

    Science.gov (United States)

    Li, Li; Zhong, Chang; Kong, Fanping

    2014-11-01

    Due to diastrophism, tide action and human activities, the coastline is always in flux. There are lots of coral islands in the south sea of China. Remote sensing survey for the coastline not only can reassert the necessity and importance of coral protection, but also can provide basic data and scientific basis for island ecologic protection, reasonable utilization of land resources. The study area named Zhao Shu Island lies in Jintong Islands of Xisha. It is a coral island which has people inhabited. Using WorldView-2 satellite remote sensing images as data sources we carry out three phases of coastline investigation and monitoring. The satellite data phases are 2002, 2010 and 2013. Firstly, affirm the bands valuable for color composition on the basis of spectral and correlation analysis. Then extract the coastline by a series of image process, such as image correction, fusion, waterline extraction and coastline revision. Finally determine the coastline types and length by artificial interpretation. The results show that the island length is gradually smaller, which means the island area is reducing. The beach bedrock coast in northern island was eroded seriously especially during the period between 2010 and 2013. In addition, the shoal head shape in the western island changed a lot.

  19. Improving cachectic symptoms and immune strength of tumour-bearing mice in chemotherapy by a combination of Scutellaria baicalensis and Qing-Shu-Yi-Qi-Tang.

    Science.gov (United States)

    Wang, Hang; Chan, Yi-Lin; Li, Tsung-Lin; Wu, Chang-Jer

    2012-05-01

    Cancer cachexia is characterised by the loss of body mass and directly compromises immune response and the quality of life of cancer patients. In the present study, we set out to investigate the role of Chinese herbs as anticancer medicines and/or chemotherapeutic adjuvants to increase therapeutic efficacy and/or ameliorate given side-effects in animal model. Twelve kinds of herbs were chosen from the ingredients of major Chinese herbal medicines, and their effects on the antioxidant activity were investigated. To obtain the anticancer effects of 5-fluorouracil (5-FU) when consumed with minimal side-effects, we investigated the combination effect of Scutellaria baicalensis and Qing-Shu-Yi-Qi-Tang that may enhance the anticancer activity of 5-FU on subcutaneous tumour growth in C57BL/6 mice challenged with Lewis lung carcinoma cells. Qing-Shu-Yi-Qi-Tang, a multiple-component herbal extract, was shown to have high anti-oxidation activity, while S. baicalensis (Chinese skullcap) was demonstrated to have high tumour-growth inhibition activity. Thus, S. baicalensis and Qing-Shu-Yi-Qi-Tang were evaluated for their combinaton effects on the cancer-induced cachectic murine upon receiving 5-FU chemotherapy. As a result, tumour masses and losses of carcass and/or gastrocnemius muscle were found to be significantly decreased. This combination otherwise increased both Th1/Th2 ratio and NK cytotoxicity. In the mice receiving with or without 5-FU, the serum levels of monocyte chemoattractant protein-1 (MCP-1) increased by all means but otherwise decreased when the herbal combination was administrated. Additionally, the expressions of nuclear factor-kappa B (NF-κB) and muscle RING finger protein-1 (MuRF-1) decreased in the gastrocnemius muscle when the herbal combination was applied. Our results revealed that the combination of S. baicalensis and Qing-Shu-Yi-Qi-Tang is able to ameliorate cachectic symptoms and positively stimulate anti-tumour immunity while undergoing

  20. Monographs in Tang Official Historiography: Perspectives from the Technical Treatises of the History of Sui (Sui shu)

    OpenAIRE

    Morgan, Daniel Patrick; Chaussende, Damien

    2018-01-01

    Finished in 656 as part of a larger project, the ten ‘treatises’ (zhi) of the current History of Sui (Sui shu) provide us with histories of such fields of technical knowledge as astronomy, astrology, omenology, economics, law, geography, metrology, and library science covering the five divided and short-lived dynasties, 502–618 CE, that were the predecessors of the Tang. This edited volume brings together young experts in these fields to reflect upon the way that their history has been writte...

  1. The role and significance of Luo Zhiyuan's Shu yi hui bian in the history of plague in Lingnan (south of the five ridges).

    Science.gov (United States)

    Li, H; Lai, W

    1999-04-01

    Being the earliest monograph on plague in China, Luo Zhiyuan's Shu yi hui bian, not included in the National Catalogue of TCM Books, include the following contents: personal idea on the etiology of plague; Luo's friend Wu Xuanchang' unpublished Shu yu zhi fa on the treatment and manifestations of plague; Luo's specific recipe for plague based on medified Wang Qingren's Jie du huo xue decoction based on Wang Qingrens yi lin gai cuo; therapy for critical cases; many therapies applied on Lingnan, including experimental recipes, external therapy, preventive methods, and preventing recurrence methods; Luo's special administrating methods, including persisting day-and-night method, immediate persisting method, single-dose persisting method, and double-dose persisting method. He also gave several cured case records. His book, featuring unique idea with good effect, was repeatedly printed and extensively distributed, exerting influence, more or less, on the plague monographs of later ages, and occupying important position in the history of plague on Lingnan and the whole country as well. His idea of "that poisons and static blood" in pathogenesis and therapeutic principle of antitoxicity and activating blood is coincided with the results of present day clinical and laboratory studies. His administration of medicines is heuristic to the therapy of critical cases with Chinese medicaments and to the recognition of pathogenesis, etiology, and treatment of modern plague as well as other diseases of similar etiology and pathognesis and is worth of further study.

  2. 3D stratigraphic forward modelling of Shu'aiba Platform stratigraphy in the Bu Hasa Field, Abu Dhabi, United Arab Emirates.

    Science.gov (United States)

    Hu, J.; Lokier, S. W.

    2012-04-01

    This paper presents the results of three dimensional sequence stratigraphic forward modelling of the Aptian age Shu'aiba Formation from Abu Dhabi, United Arab Emirates (UAE). The Shu'aiba Formation lies within the uppermost part of the Lower Cretaceous Thamama Group and forms one of the most prolific hydrocarbon reservoir intervals of the Middle East with production dating back to the 1960's. The Shu'aiba Formation developed as a series of laterally-extensive shallow-water carbonate platforms in an epeiric sea that extended over the northern margin of the African-Arabian Plate. This shallow sea was bounded by the Arabian Shield to the west and the passive margin with the Neo-Tethys Ocean towards the north and east (Droste, 2010). The exposed Arabian Shield acted as a source of siliciclastic sediments to westernmost regions, however, more offshore areas were dominated by shallow-water carbonate deposition. Carbonate production was variously dominated by Lithocodium-Baccinella, orbitolinid foraminifera and rudist bivalves depending on local conditions. While there have been numerous studies of this important stratigraphic interval (for examples see van Buchem et al., 2010), there has been little attempt to simulate the sequence stratigraphic development of the formation. During the present study modelling was undertaken utilising the CARBONATE-3D stratigraphic forward modelling software (Warrlich et al., 2008; Warrlich et al., 2002)) thus allowing for the control of a diverse range of internal and external parameters on carbonate sequence development. This study focuses on platform development in the onshore Bu Hasa Field - the first giant oilfield to produce from the Shu'aiba Formation in Abu Dhabi. The carbonates of the Bu Hasa field were deposited on the southwest slope of the intra-shelf Bab Basin, siliciclastic content is minor. Initially these carbonates were algal dominated with rudist mounds becoming increasingly important over time (Alsharhan, 1987

  3. Metabonomics Combined with UPLC-MS Chemical Profile for Discovery of Antidepressant Ingredients of a Traditional Chinese Medicines Formula, Chaihu-Shu-Gan-San

    Directory of Open Access Journals (Sweden)

    Hongmei Jia

    2013-01-01

    Full Text Available This study proposed a new strategy for uncovering the active chemical constituents of a traditional Chinese medicines (TCMs formula, Chaihu-Shu-Gan-San (CSGS. Metabonomics and chemical profile were integrated in combination with the multivariate statistical analysis (MVA to discover the chemical constituents which contribute to the antidepressant effect of CSGS. Based upon the difference between CSGS and QZ (CSGS without Zhi-Qiao extracts in the chemical profiles and the regulations of metabolic disturbances induced by CUMS, synephrine, naringin, hesperidin, and neohesperidin were recognized as the active constituents of CSGS from Zhi-qiao responsible for those missing regulations of CSGS when Zhi-Qiao was subtracted from the whole formula. They participated in the regulations of the deviated metabolites 2–4, 10–14, and 22–25, involved in metabolic pathways of ketone bodies synthesis, phenylalanine, tyrosine and tryptophan biosynthesis, valine, aspartate, glutamate metabolism, and glycolysis/gluconeogenesis. Furthermore, the assay of MAO-A activity confirmed the potential antidepressant effect of naringin and its active sites on the MAO-A was inferred by molecular docking study. The integration of metabonomics and chemical profile was proved to be a useful strategy for uncovering what the active chemical constituents in TCM formula are and how they make contributions for the efficacy of the formula.

  4. Identification of the chemical constituents of Chinese medicine Yi-Xin-Shu capsule by molecular feature orientated precursor ion selection and tandem mass spectrometry structure elucidation.

    Science.gov (United States)

    Wang, Hong-ping; Chen, Chang; Liu, Yan; Yang, Hong-Jun; Wu, Hong-Wei; Xiao, Hong-Bin

    2015-11-01

    The incomplete identification of the chemical components of traditional Chinese medicinal formula has been one of the bottlenecks in the modernization of traditional Chinese medicine. Tandem mass spectrometry has been widely used for the identification of chemical substances. Current automatic tandem mass spectrometry acquisition, where precursor ions were selected according to their signal intensity, encounters a drawback in chemical substances identification when samples contain many overlapping signals. Compounds in minor or trace amounts could not be identified because most tandem mass spectrometry information was lost. Herein, a molecular feature orientated precursor ion selection and tandem mass spectrometry structure elucidation method for complex Chinese medicine chemical constituent analysis was developed. The precursor ions were selected according to their two-dimensional characteristics of retention times and mass-to-charge ratio ranges from herbal compounds, so that all precursor ions from herbal compounds were included and more minor chemical constituents in Chinese medicine were identified. Compared to the conventional automatic tandem mass spectrometry setups, the approach is novel and can overcome the drawback for chemical substances identification. As an example, 276 compounds from the Chinese Medicine of Yi-Xin-Shu capsule were identified. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Online identification of the antioxidant constituents of traditional Chinese medicine formula Chaihu-Shu-Gan-San by LC-LTQ-Orbitrap mass spectrometry and microplate spectrophotometer.

    Science.gov (United States)

    Su, Zhi-Heng; Zou, Guo-An; Preiss, Alfred; Zhang, Hong-Wu; Zou, Zhong-Mei

    2010-11-02

    Chaihu-Shu-Gan-San (CSGS), a traditional Chinese medicine (TCM) formula containing seven herbal medicines, has been used in treatment of gastritis, peptic ulcer, irritable bowel syndrome and depression clinically. However, the chemical constituents in CSGS had not been studied so far. To quickly identify the chemical constituents of CSGS and to understand the chemical profiles related to antioxidant activity of CSGS, liquid chromatography coupled with electrospray ionization hybrid linear trap quadrupole orbitrap (LC-LTQ-Orbitrap) mass spectrometry has been applied for online identification of chemical constituents in complex system, meanwhile, antioxidant profile of CSGS was investigated by the fraction collecting and microplate reading system. As a result, 33 chemical constituents in CSGS were identified. Among them, 13 components could be detected both in positive and in negative ion modes, 20 constituents were determined only in positive ion mode and 2 components were only detected in negative ion mode. Meanwhile, the potential antioxidant profile of CSGS was also characterized by combination of 96-well plate collection of elutes from HPLC analysis and microplate spectrophotometer, in which the scavenging activities of free radical produced by DPPH of each fraction could be directly investigated by the analysis of microplate reader. This study quickly screened the contribution of CSGS fractions to the antioxidant activity and online identified the corresponding active constituents. The results indicated that the combination of LC-MS(n) and 96-well plate assay system established in this paper would be a useful strategy for correlating the chemical profile of TCMs with their bioactivities without isolation and purification. Crown Copyright (c) 2010. Published by Elsevier B.V. All rights reserved.

  6. Hippocampus and serum metabolomic studies to explore the regulation of Chaihu-Shu-Gan-San on metabolic network disturbances of rats exposed to chronic variable stress.

    Science.gov (United States)

    Su, Zhi-heng; Jia, Hong-mei; Zhang, Hong-wu; Feng, Yu-Fei; An, Lei; Zou, Zhong-mei

    2014-03-04

    Chaihu-Shu-Gan-San (CSGS), a traditional Chinese medicine formula, has been effectively used for the treatment of depression. However, studies of its anti-depressive mechanism are challenging, due to the complex pathophysiology of depression, and complexity of CSGS with multiple constituents acting on different receptors. In the present work, metabolomic studies of biochemical changes in the hippocampus and serum of chronic variable stress (CVS)-induced depression rats after treatment with CSGS were performed using ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). Partial least squares-discriminate analysis indicated that the metabolic perturbation induced by CVS was reduced by treatment with CSGS. A total of twenty-six metabolites (16 from the hippocampus and 10 from serum) were considered as potential biomarkers involved in the development of depression. Among them, 11 were first reported to have potential relevance in the pathogenesis of depression, and 25 may correlate to the regulation of CSGS treatment on depression. The results combined with a previous study indicated that CSGS mediated synergistically abnormalities of the metabolic network, composed of energy metabolism, synthesis of neurotransmitters, tryptophan, phospholipids, fatty acid and bile acid metabolism, bone loss and liver detoxification, which may be helpful for understanding its mechanism of action. Furthermore, the extracellular signal-regulated kinase (ERK) signal pathway, involved in the neuronal protective mechanism of depression related to energy metabolism, was investigated by western blot analysis. The results showed that CSGS reversed disruptions of BDNF, ERK1/2 and pERK1/2 in CVS rats, which provides the first evidence that the ERK signal system may be one of the targets related to the antidepressant action of CSGS.

  7. A comparative pharmacokinetic study of three flavonoids and three anthraquinones in normal and gastrointestinal motility disorders rat plasma after the oral administration of Wei-Chang-Shu tablet using high-performance liquid chromatography-tandem mass spectrometry.

    Science.gov (United States)

    Ren, Yan; Zhao, Weiwei; Zhao, Juanjuan; Chen, Xiangming; Yu, Chen; Liu, Mengan

    2017-11-01

    A simple, fast and reliable high-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous quantification and pharmacokinetic study of three flavonoids (liquiritigenin, isoliquiritigenin and formononetin) and three anthraquinones (emodin, rhein and aloe-emodin), which are the bioactive ingredients of Wei-Chang-Shu tablet found in rat plasma. After extraction by liquid-liquid extraction with ethyl acetate, chromatographic separation was achieved on an Agilent Zorbax SB-C 18 column (4.6 × 150 mm, 5 μm) at a flow rate of 1 mL/min by gradient elution using 0.1% aqueous acetic acid and acetonitrile. The detection was performed using a triple quadrupole mass spectrometer equipped with electrospray ionization source in the negative ionization and selected reaction monitoring mode. Method validation was performed in terms of specificity, carryover, linearity (r > 0.99), intra-/inter-day precision (1.0-10.1%), accuracy (relative error, <7.6%), stability (0.6-13.2%), extract recovery (74.9-91.9%) and matrix effect (89.1-109%). The lower limits of quantification of the six analytes varied from 0.92 to 10.4 ng/mL. The validated method was successfully applied to compare the pharmacokinetic properties of Wei-Chang-Shu tablet in normal rats and in rats with gastrointestinal motility disorders. The results indicated that there were obvious differences in the pharmacokinetic behavior between normal and model rats. This study will be helpful in the clinical application of Wei-Chang-Shu tablet. Copyright © 2017 John Wiley & Sons, Ltd.

  8. Simultaneous determination of phenolic acids and diterpenoids and their comparative pharmacokinetic study in normal and acute blood stasis rats by UFLC-MS/MS after oral administration of Guan-Xin-Shu-Tong capsules.

    Science.gov (United States)

    Gao, Xun; Mu, Jingqing; Guan, Shaoyi; Li, Qing; Du, Yiyang; Zhang, Huifen; Bi, Kaishun

    2018-01-01

    Guan-Xin-Shu-Tong capsules are one of the well-known and first-line Chinese traditional herbal formula for treating coronary heart disease. A validated and sensitive method via ultra fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) was established to simultaneously determinate five phenolic acids and four diterpenoids in rats in order to investigate their pharmacokinetic profiles firstly. Analytes were extracted by ethyl acetate and determined via multiple reaction monitoring mode in both positive and negative ion modes. The values for limit of quantification were in range of 0.025-1.250ng/ml. Inter- and intra-day precisions were no more than 10.9% with accuracy of -11.0%-10.6%, meanwhile the stable and suitable extraction recoveries were also obtained. And finally such excellent method was used to compare the pharmacokinetics of nine compounds in normal and acute blood stasis rats after oral administration of Guan-Xin-Shu-Tong capsules. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. 晏殊词“思致”表现形态探微%The Exploratory of the Form of Expression on Yan Shu's“Best Level Thoughts of his Heart” Poems

    Institute of Scientific and Technical Information of China (English)

    曹章庆

    2013-01-01

      晏殊属思深意远的“心境型”作家,故其词无论咏物、感怀或闺思,无不体现深沉澄明的“思致”。其思致形态又可分为“无心”、“有意”两类。“无心”者在直觉中隐含思致,它或描摹以烘染意蕴;或写意以潜伏哲思,甚至不着一字,尽得风流。“有意”者在直觉中显露思致,它或兴寄而言情志,或点染衬托以表意旨,虽可实指却意在象外,迷离蕴藉。“无心”、“有意”两种形态虽各有别,但在深层心理上都是作者理性观照的产物,是晏殊对人情世态、历史人生洞悟穿透的诗性智慧结晶。%Yan Shu is a kind of the “mood” type writer who has far profound thoughts ,therefore ,no matter the poems on things ,emotion or deep house thinking ,all reflect the deep clear “the best level thoughts of his heart ” .The thought form can be divided into “unintentionally”and“intentionally” .“Un‐intentional” means“the best level thoughts of his heart” is implied in the intuition ,or tracing to the deep meaning through portray ;Or latent philosophizing through freehand brushwork ,even “all having to love without a word” .“Intentionally”means“the best level thoughts of his heart”is emerged in the intuition , or expressing the emotion through prospering ,or foiling to his will through halftone ,although That de‐picts the real thing ,it real means is outside ,so as false blurred .“Unintentionally”and“intentionally” are different ,but the deep psychology is the product of rational view ,and it is the poetic wisdom crystalliza‐tion that Yan Shu enlightens the ways of the world and the history of human life .

  10. A model for the Lin-Shu type density-wave structure of our Galaxy: Line-of-sight and transverse-longitudinal velocities of 242 optically visible open clusters

    Science.gov (United States)

    Griv, E.; Jiang, I.-G.

    2015-02-01

    In this paper, the fourth in a series, we examine again one of the implications of the Lin-Shu density-wave theory, specifically, the noncircular systematic motion of the Galactic objects. Our previous investigation is extended by analyzing simultaneously both the line-of-sight and transversal velocities of a sample of open clusters for which velocities, distances and ages are available. The ordinary equations of the Oort-Lindblad theory of galactic differential rotation are used. The minor effects caused by the two-dimensional tightly-wound density waves are also taken into account. The published data of 242 currently known optically visible clusters having distances rsight and transversal along the Galactic longitude velocities are nearly equal. We argue that the resemblance of these Galactic wave structures is so remarkable that no doubt is felt as to the theory's truth with respect to these data. The results obtained allow us to conclude that several low-m trailing density-wave patterns with different number of spiral arms m (say, m=1, 2, 3, and 4), pitch angles (about 5o, 8o, 11o, and 14o, respectively) and amplitudes of the perturbed gravitational potential may coexist in the Galaxy. The latter suggests the asymmetric multiarm, not well-organized (``flocculent'') spiral structure of the system. In memory of Professors Alexei M. Fridman (1940-2010) and Chi Yuan (1937-2008)

  11. Socioeconomic differences in prevalence, awareness, control and self-management of hypertension among four minority ethnic groups, Na Xi, Li Shu, Dai and Jing Po, in rural southwest China.

    Science.gov (United States)

    Cai, L; Dong, J; Cui, W L; You, D Y; Golden, A R

    2017-06-01

    This study investigates socioeconomic differences in prevalence, awareness, control and self-management of hypertension in rural China. A cross-sectional survey was conducted among four ethnic minority groups in Yunnan Province: Na Xi, Li Shu, Dai and Jing Po. Approximately 5532 consenting individuals aged ⩾35 years (48.4% of whom were male) were selected to participate in the study using a stratified, multistage sampling technique. Information about participants' demographic characteristics and hypertension awareness, treatment, control and self-management practices was obtained using a standard questionnaire. The age-standardised prevalence of hypertension in the study population was 33.6%. In hypertensive subjects, the overall levels of awareness, treatment and control of hypertension were 42.1%, 28.5% and 6.7%, respectively. Approximately 58.7% of hypertensive patients regularly self-monitored blood pressure (BP), 64.7% adhered to their physician-prescribed anti-hypertensive drugs, and 88.0% took at least one measure to control BP. Hypertensive patients of Jing Po ethnicity had the lowest rates of awareness, treatment, control and self-management of hypertension among the four ethnic minority groups studied. Individuals with lower levels of education were more likely to be hypertensive. Further, individuals with lower levels of education had a lower probability of awareness of their hypertensive status and of treatment with antihypertensive medication. Access to medical services was positively associated with awareness of suffering from hypertension, being treated with antihypertensive medication, and compliance with antihypertensive drug treatment. This study suggests that effective strategies to enhance awareness, treatment and management of hypertension should focus on individuals with low levels of education and poor access to medical services.

  12. Ling Shu-hua’s Novels:Different Structure but Same Spirit Compared with the Soul of Era%凌叔华小说:与时代精魂异构而同质

    Institute of Scientific and Technical Information of China (English)

    吴政家; 凌端明

    2014-01-01

    中国的女性自古就受到男性话语的塑造,她们自身也认同并自觉担起了这种强加在她们身上的霸权话语。直到五四时期,在西方女权思潮的吹拂下,女性才意识到了自身的主体性和独特性。凌叔华小说以其细腻、平和、不动声色的女性叙事视角,异于同时代女作家的叙事策略,为我们展现了那一时代女性如何被塑造为“女人”的事实和她们部分人的觉醒、困顿和挣扎,呈现出与五四时代精魂异构而同质的个性。%The Chinese woman are modeled by power of men continues a long time, and they agree with these attitudes and bear the hegemonic discourse voluntarily. Female realized the subjectivity and unique in themselves under the blowing of western feminism until the period of May-4th. Ling SHu-hua’s novels with its perspective of female narrative different from others writers in the period of May-4th.Her novels displayed the fact of modeled women whose awaken and struggled .Its writing personality seems present different structure but contains the same nature just as the spirit of May-4th.

  13. Erken Tabgaç (T’o-pa Tarihinin Ana Hatları (Wei Shu’nun İlk Bölümüne Göre Outlines of Early Tabgach (T’o-pa History (According to First Chapter of Wei Shu

    Directory of Open Access Journals (Sweden)

    Kürşat YILDIRIM

    2012-09-01

    Full Text Available The History of Tabgach Turks who recorded in Chinese sources under the name of T’o-pa is little known. Tabgachs dominated on Northern China in 386 AD, governed China for nearly two centuries and finally disappeared from the stage of history by becoming Chinese people. Some scholars investigated this period of Tabgachs. However, their emergence to stage of history and their history until 386 AD are little studied. Tabgachs begun to take place in the Chinese sources in years about 160-170. They strengthened their state formation anddominated on all of their neighbors in the period of Li-wei (220-277.They established Tai State under the reign of I-lu in 314 and this statelasted until 376. Especially in the reign of Shih-i-chien (338-376,Tabgach State strengthened and extended its domination from Liaoningin east to Ferghana in west. Largest state formation of Tabgachs isNorthern Wei State that dominated all of China and later becameChinese. Our article aims to study this period lasted until 386 based onfirst chapter of Wei Shu that is official dynastic history of TabgachDynasty. Besides this, it is applied to main sources as Shih Chi, HanShu, Hou Han Shu, San Kuo Chih, Chin Shu, T’ai P’ing Yü Lan, Ts’e FuYüan Kuei, T’ung Chih, Wen Hsien T’ung Kao, Tzu Chih T’ung Chien,T’ung Tien and research studies. We hope to contribute to later studieson political history, linguistics, cultural history about Tabgachs withour study in General Turkic History. Çin kaynaklarında T’o-pa adı altında kaydedilen Tabgaç Türklerinin tarihleri az bilinmektedir. Tabgaçlar M.S. 386 yılında Kuzey Çin’e hâkim oldular, yaklaşık iki yüzyıl Çin’i idâre ettiler ve nihayetinde Çinlileşip tarih sahnesinden çekildiler. Bazı âlimler Tabgaçların bu devrini incelemişlerdir. Bununla beraber Tabgaçların tarih sahnesine çıkışları ve 386 yılına kadar olan tarihleri pek çalışılmamıştır. Tabgaçlar 160-170 yıllarında

  14. Prof. Frank Shu | Academy – Springer Nature chair | About IASc ...

    Indian Academy of Sciences (India)

    The Astrophysics of Thorium Molten-Salt Breeder Reactors*; 12/12/2017 ... and high-mass stars in a globular cluster, the basic equations for which were ... from knowing how white dwarf stars cool by stages to a final inert state as a solid.

  15. Efficient fuzzy logic controller for magnetic levitation systems | Shu ...

    African Journals Online (AJOL)

    In this paper magnetic levitation controller using fuzzy logic is proposed. The proposed Fuzzy logic controller (FLC) is designed, and developed using triangular membership function with 7×7 rules. The system model was implemented in MATLAB/SIMULINK and the system responses to Fuzzy controller with different input ...

  16. FY 1998 new energy data book; 1998 nendo shin energy data shu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-01

    In relation to the new energy the use of which is promoted by New Energy and Industrial Technology Development Organization (NEDO), this book arranged the information on the technical trend and legal system. It includes the following items: (I) New energy general (classification of new energy, forecast of energy supply/demand, cost and outlook for the introduction of new energy technology (new power generation), menu of buying the surplus electric power from electric power company, main subsidy systems for spread/promotion of new energy in Japan, policy/law/subsidy system related to introduction of new energy overseas, list of organizations for new energy technology development). The items of individual explanation of new energy are as follows: situations of the introduction in each country, situation of the introduction in Japan, policy in each country, subsidy system, present market situation (photovoltaic power generation), list of names/telephone Nos. of the related companies, and economical efficiency (solar heat utilization). The following new energies were studied: (II) Photovoltaic power generation. (III) Solar energy utilization. (IV) Wind power generation. (V) Fuel cell. (VI) Waste power generation. (VII) Cogeneration. (VIII) Unused energy. (IX) geothermal power generation. (X) Clean energy automobile. (XI) Coal liquefaction/gasification. (NEDO)

  17. VizieR Online Data Catalog: VLBI Ecliptic Plane Survey: VEPS-1 (Shu+, 2017)

    Science.gov (United States)

    Shu, F.; Petrov, L.; Jiang, W.; Xia, B.; Jiang, T.; Cui, Y.; Takefuji, K.; McCallum, J.; Lovell, J.; Yi, S.-O.; Hao, L.; Yang, W.; Zhang, H.; Chen, Z.; Li, J.

    2017-08-01

    We began observations in the search mode in 2015 February. The participating stations included the three core stations of the Chinese VLBI Network (CVN): seshan25, kunming, and urumqi. Depending on the participating stations, the longest baseline length in each session can be varied from 3200km to 9800km. Our observations were performed at a 2048Mbps data rate, with 16 Intermediate Frequency (IF) channels and 2-bit sampling. The first eight IFs of 32MHz bandwidth were distributed in the range of [8.188, 8.444]GHz, and the remaining eight IFs of 32MHz bandwidth were in the range of [8.700, 8.956]GHz. Table 1: Summary of the VLBI Ecliptic Plane Survey (VEPS) observations in search mode: --------------------------------------------------- Date Dur. Code Stations Number of (Y/M/D) (h) Targets --------------------------------------------------- 2015 Feb 13 24 VEPS01 ShKmUr 293 2015 Feb 14 24 VEPS02 ShKmUr 338 2015 Apr 23 24 VEPS03 UrKv 300 2015 Apr 24 24 VEPS04 ShKmUrKv 400 2015 Aug 10 25 VEPS05 ShKmKvHo 252 2015 Aug 19 25 VEPS06 ShKmKvHo 277 2016 Mar 02 24 VEPS07 ShKmUrKb 333 2016 Mar 11 24 VEPS08 ShKmUrKb 477 2016 May 13 24 VEPS09 ShUrHo 291 2016 May 14 22 VEPS10 ShUrKv 322 2016 Jul 06 24 VEPS11 ShUrKb 307 2016 Sep 02 23 VEPS12 ShUr 424 2016 Sep 03 23 VEPS13 ShKmUr 344 --------------------------------------------------- Sh=Seshan25; Km=Kunming; Ur=Urumqi; Kv=Sejong; Kb=Kashim34; Ho=Hobart26. --------------------------------------------------- We ran two absolute astrometry dual-band VLBA programs that targeted ecliptic plane compact radio sources: the dedicated survey of weak ecliptic plane calibrators with the VLBA BS250 program in 2016 March-May, and the VLBA Calibrator Survey 9 (VCS-9) in 2015 August-2016 September. The International VLBI Service for Geodesy and Astrometry (IVS) runs a number of VLBI observing programs. We made an attempt to improve the coordinates of some VEPS sources detected in the search mode and provide additional measurements of telescope position with the same experiments in two such 24hr sessions, AOV010 in July and AUA012 in 2016 August. (2 data files).

  18. FY 1997 new energy data book; 1997 nendo shin energy data shu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    In relation to the new energy the use of which is promoted by New Energy and Industrial Technology Development Organization (NEDO), this book arranged the information on the technical trend and legal system. It includes the following items: (I) New energy general (classification of new energy, forecast of energy supply/demand, cost and outlook for the introduction of new energy technology (new power generation), menu of buying the surplus electric power from electric power company, main subsidy systems for spread/promotion of new energy in Japan, policy/law/subsidy system related to introduction of new energy overseas, list of organizations for new energy technology development). The items of individual explanation of new energy are as follows: situations of the introduction in each country, situation of the introduction in Japan, policy in each country, subsidy system, present market situation, economical efficiency, etc. The following new energies were studied: (II) Photovoltaic power generation. (III) Solar energy utilization. (IV) Wind power generation. (V) Fuel cell. (VI) Waste power generation. (VII) Cogeneration. (VIII) Unused energy. (IX) geothermal power generation. (X) Clean energy automobile. (XI) Coal liquefaction/gasification. (XII) List of the outline of policies concerning new energy, energy conservation and reduction of environmental loads. (NEDO)

  19. New energy data handbook. Fiscal 1999 edition; Shin energy data shu (1998 nendo ban)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    Enumerated concerning new energy in general are the classification of new energy; prospect of energy demand and supply; cost of new energy; policies, laws and regulations, and subsidy systems for new energy in Japan and abroad; etc. Concerning photovoltaic power generation, the introduction of photovoltaic systems, policies toward photovoltaic systems, subsidy systems, the current state of market in Japan and abroad, etc., are mentioned. Similar data are also listed about solar heat exploitation and wind power generation. Concerning fuel cells, the phosphoric acid fuel cell demonstration plant and the result of its operation, the state of development achieved so far in the molten carbonate type, the polymer electrolyte type, and the methanol type are stated. In addition, details are mentioned of refuse-fueled power generation, co-generation, energy remaining unexploited, geothermal power generation, clean energy vehicles, coal liquefaction and gasification, etc. (NEDO)

  20. AgRP(83—132) and SHU9119 differently affect activity-based anorexia

    NARCIS (Netherlands)

    Kas, M.J.H.; Hillebrand, J.J.G.; Scheurink, A.J.W.; Adan, R.A.H.; Dijk, G. van

    2005-01-01

    Activity-based anorexia (ABA) mimics starvation and hyperactivity of anorexia nervosa patients in rats. Activation of the melanocortin (MC) system leads to hypophagia and increased energy expenditure in ad libitum fed rats. Therefore, activation of the MC system might underlie the development and

  1. AgRP(83—132) and SHU9119 differently affect activity-based anorexia

    NARCIS (Netherlands)

    Hillebrand, Jacquelien J. G.; Kas, Martien J.H.; Scheurink, Anton J. W.; van Dijk, Gertjan; Adan, Roger A. H.

    Activity-based anorexia (ABA) mimics starvation and hyperactivity of anorexia nervosa patients in rats. Activation of the melanocortin (MC) system leads to hypophagia and increased energy expenditure in ad libitum fed rats. Therefore, activation of the MC system might underlie the development and

  2. Research for a database of alternative energy technologies; Miriyo energy ni kansuru data shu sakusei chosa

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    The paper collects and arranges data on the unused energy in terms of examples of the introduction in Japan and other countries, policies, laws and rules, subsidy systems, etc. In the overview of the system, described was typical heat supply systems utilizing unused energy. As to concrete examples of the introduction in Japan, the examples were arranged by unused energy source, by temperature level, and by region, and a detailed data book of the typical introduction examples was made. As to examples overseas, data were arranged on the introduction mainly in Europe and the U.S. With relation to policies, laws and rules, and subsidy systems in Japan and overseas, investigated were policies, laws and rules, and subsidy systems concerning unused energy mostly in Japan, Europe and the U.S. As to the production quantity, the actual amount of introduction, and the predicted amount of introduction, survey on the effect and arrangement of the data were conducted in terms of typical two heat supply facilities utilizing unused energy. The paper adds information pertaining to the cost, main related companies and groups, the distribution cost, etc.

  3. Research on choleretic effect of menthol, menthone, pluegone, isomenthone, and limonene in DanShu capsule.

    Science.gov (United States)

    Hu, Guanying; Yuan, Xing; Zhang, Sanyin; Wang, Ruru; Yang, Miao; Wu, Chunjie; Wu, Zhigang; Ke, Xiao

    2015-02-01

    Danshu capsule (DSC) is a medicinal compound in traditional Chinese medicine (TCM). It is commonly used for the treatment of acute & chronic cholecystitis as well as choleithiasis. To study its choleretic effect, healthy rats were randomly divided into DSC high (DSCH, 900mg/kg), medium (DSCM, 450mg/kg), and low (DSCL, 225mg/kg) group, Xiaoyan Lidan tablet (XYLDT, 750mg/kg), and saline group. The bile was collected for 1h after 20-minute stabilization as the base level, and at 1h, 2h, 3h, and 4h after drug administration, respectively. Bile volume, total cholesterol, and total bile acid were measured at each time point. The results revealed that DSC significantly stimulated bile secretion, decreased total cholesterol level and increased total bile acid level. Therefore, it had choleretic effects. To identify the active components contributing to its choleretic effects, five major constituents which are menthol (39.33mg/kg), menthone (18.02mg/kg), isomenthone (8.18mg/kg), pluegone (3.31mg/kg), and limonene (4.39mg/kg) were tested on our rat model. The results showed that menthol and limonene could promote bile secretion when compared to DSC treatment (p > 0.05); Menthol, menthol and limonene could significantly decrease total cholesterol level (plimonene. Crown Copyright © 2014. Published by Elsevier B.V. All rights reserved.

  4. 75 FR 32741 - Action Affecting Export Privileges; Shu Quan-Sheng

    Science.gov (United States)

    2010-06-09

    ... illegally exporting space launch technical data and defense services to the People's Republic of China and offering bribes to Chinese government officials. Quan-Sheng was sentenced to 51 months in prison, two years... Regulations; B. Take any action that facilitates the acquisition or attempted acquisition by the Denied Person...

  5. Data book of new energy introduction to Hokkaido. FY 2000 version; Hokkaido shin energy donyu data shu. 2000 nendoban

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    For the purpose of effectively introducing/promoting new energy and of supplying the basic data which contribute to the promotion/education, the actual results of new energy introduction to Hokkaido were collected/arranged. New energies to be surveyed were the photovoltaic power generation, solar heat utilization, wind power generation, waste power generation, waste heat utilization, waste fuel production, biomass energy, unused energy, gas generation, petroleum cogeneration, fuel cells, clean energy vehicles, small-/medium-scale hydroelectric power generation, etc. The purpose of the book is mainly to collect the basic information, that is, what kind of new energy has been introduced to what kind of area. The data are so collected that facilities adopting new energy can be seen as unit of city/town/village as a rule. The method to collect information is based on the total collection of the reports made by organizations in/outside Hokkaido. The book additionally covers the details of the data supplied and the data collected. (NEDO)

  6. 78 FR 2423 - Draft Environmental Impact Statement (DEIS) for the Proposed Shu'luuk Wind Project on the Campo...

    Science.gov (United States)

    2013-01-11

    ... to 80 2-MW wind turbines (totaling 160 MW from wind) in combination with up to 40 1-MW solar photovoltaic (PV) panels (totaling 40 MW from solar). Each turbine would generate 2 MW, have a hub height up to... solar energy generation. The approval of the lease would allow Invenergy, LLC to develop and operate a...

  7. Outline and summary of research for a database of unused energy technologies; Miriyo energy ni kansuru data shu sakusei chosa

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    For effective promotion of the new energy utilization project of NEDO and preparation of the future new energy vision, the data on unused energy were systematically arranged. The definition of heat supply systems using unused energy was clarified, and the kind and property of unused energy were arranged. Some typical systems of heat supply facilities using unused energy were presented. The data were classified by energy source, temperature level and region, and the detailed database was prepared for the typical systems. The overseas database was prepared, in particular, for European and American systems. Domestic and overseas policies, laws and subsidy systems were arranged. The introduction effect of two heat supply facilities using unused energy was surveyed, and their operation costs were analyzed. Basic terminology related to unused energy was compiled and explained. Related organizations, in particular, manufacturers were surveyed and arranged. The main manufacturers of a heat recovery refrigerator and waste heat boiler as typical equipment, and the number of these equipment shipped were arranged. 51 figs., 116 tabs.

  8. FY 1999 data book for the introduction of new energy to Hokkaido; 1999 nendoban Hokkaido shin energy donyu data shu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    For the purpose of effectively promoting the introduction of new energy to Hokkaido, it is necessary to comprehensively/systematically arrange various kinds of new energy and to furnish the basic data which contribute to the spread/education. The paper collected/arranged the actual results of the introduction of new energy to Hokkaido, using the existing data, etc. Attention is paid to the collection of the basic information on what kinds of new energy have been introduced in what kinds of regions, etc. Fundamentally, the data were collected by which facilities for new energy can be seen by city/town/village. The new energy for collection is basically within the range of those included in the New Energy Law. They are renewable energy (photovoltaic power generation, solar heat utilization, and wind power generation); recycle type energy (waste power generation, waste heat utilization, fuel production, waste fuel production, biomass energy, and unused energy); new forms of the existing energy (gas/oil cogeneration, fuel cell, and clean energy vehicle). (NEDO)

  9. Changes in flavour and microbial diversity during natural fermentation of suan-cai, a traditional food made in Northeast China.

    Science.gov (United States)

    Wu, Rina; Yu, Meiling; Liu, Xiaoyu; Meng, Lingshuai; Wang, Qianqian; Xue, Yating; Wu, Junrui; Yue, Xiqing

    2015-10-15

    We measured changes in the main physical and chemical properties, flavour compounds and microbial diversity in suan-cai during natural fermentation. The results showed that the pH and concentration of soluble protein initially decreased but were then maintained at a stable level; the concentration of nitrite increased in the initial fermentation stage and after reaching a peak it decreased significantly to a low level by the end of fermentation. Suan-cai was rich in 17 free amino acids. All of the free amino acids increased in concentration to different degrees, except histidine. Total free amino acids reached their highest levels in the mid-fermentation stage. The 17 volatile flavour components identified at the start of fermentation increased to 57 by the mid-fermentation stage; esters and aldehydes were in the greatest diversity and abundance, contributing most to the aroma of suan-cai. Bacteria were more abundant and diverse than fungi in suan-cai; 14 bacterial species were identified from the genera Leuconostoc, Bacillus, Pseudomonas and Lactobacillus. The predominant fungal species identified were Debaryomyces hansenii, Candida tropicalis and Penicillium expansum. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. Suan Zao Ren Tang as an Original Treatment for Sleep Difficulty in Climacteric Women: A Prospective Clinical Observation

    OpenAIRE

    Chia-Hao Yeh; Christof K. Arnold; Yen-Hui Chen; Jung-Nein Lai

    2011-01-01

    Little scientific evidence supports the efficacy of herbal medicines in the treatment of women with sleep difficulty during the climacteric period. The purpose of this study is to evaluate the efficacy and safety of Suan Zao Ren Tang (SZRT) in reducing the impact of sleep disturbance on climacteric women, as measured by Pittsburg sleep quality index (PSQI) and the World Health Organization quality of life (WHOQOL). Sixty-seven climacteric women with sleep difficulty intending to treat receive...

  11. Analyzing Behaviour of the Utilization of the Online News Clipping Database: Experience in Suan Sunandha Rajabhat University

    OpenAIRE

    Siriporn Poolsuwan; Kanyarat Bussaban

    2014-01-01

    This research aims to investigate and analyze user’s behaviour towards the utilization of the online news clipping database at Suan Sunandha Rajabhat University, Thailand. Data is gathered from 214 lecturers and 380 undergraduate students by using questionnaires. Findings show that most users knew the online news clipping service from their friends, library’s website and their teachers. The users learned how to use it by themselves and others learned by training of SSRU library. Most users us...

  12. The Health Effects of Computer Use on Personnel at the Suan Sunandha Rajabhat University

    Directory of Open Access Journals (Sweden)

    Rujijan Vichivanives

    2015-07-01

    Full Text Available This survey research aimed to find the health effects of computer use on Suan Sunandha Rajabhat University’s personnel. A total of 312 samples were selected out of 1401 population by simple random method. Inferential statistics were used throughout the hypothesis testing and data analysis (percentage, mean and standard deviation. The correlation between risk factors and computer-used behavior were calculated by Pearson correlation and Creamer’s V coefficient (95% CI. The results indicated that the samples spend 6-10 hours of the workday on the computer. In order to create a good working environment, the organization has provided good computing facilities. The overview of computer-used behavior suggests that the personnel have regular good practice, i.e. 5-6 times per week. The research result found that the most of personnel have a regular eyestrain, eye fatigue, sore eyes and irritation symptoms at least 5-6 times per week. In addition, the personnel have regular neck, shoulder, back, waist and wrist pain symptoms at least 3-4 times per week. The result indicated that the computer user’s behavior and user’s health status relate to each other, and are in the same way. In conclusion, the academic staff requires the basic computer usage knowledge in order to avoid future health problems.

  13. Survey on construction of the database for new energy technology development. Fuel cell; Shin energy gijutsu kaihatsu kankei data shu sakusei chosa. Nenryo denchi

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    As a part of the data related to technological development of new energy, the database for fuel cells was prepared. The major international conferences held in fiscal 1996 were reviewed. As the atmosphere of the whole conference, phosphoric acid fuel cell (PAFC) is in a stage just before practical use, and molten carbonate fuel cell (MCFC) is in a stage of the demonstration study of MW class one. The study on solid oxide fuel cell (SOFC) and polymer electrolyte fuel cell (PEFC) is in considerable progress. In particular, the application of PEFC to automobiles is in real investigation. For the database, kinds and features of various fuel cells, operation principles, system configurations of FC plants, application fields, and characteristics were arranged. Field test examples for public and industrial uses were separately arranged, and in particular, the application examples of PAFC were presented together with developmental conditions of the other fuel cells. Overseas situations were equal to domestic ones, and their marketability was predicted. The Japanese subsidy policy and some U.S. policies were also arranged. 28 refs., 51 figs., 37 tabs.

  14. 專論/專利指標發展研究/阮明淑、梁峻齊(Ming-Shu Yuan, Chun-Chi Liang

    Directory of Open Access Journals (Sweden)

    阮明淑、梁峻齊 Ming-Shu Yuan, Chun-Chi Liang

    2009-10-01

    Full Text Available 有鑑於專利資訊在現今產業發展中扮演重要的角色,專利指標成為度量專利資訊的重要參考。本文整理專利指標的發展演進及其在臺灣地區的相關研究,歸納出專利指標的應用分類與意涵。目前在臺灣地區的專利指標相關應用研究中,可以將專利指標區分為專利一般特性指標、專利引用指標與專利技術指標等,分別描述專利的一般特徵、引用與被引用的情況,以及技術的表現。如此正好呈現專利資訊的本質,若再配合時間與專業領域的因素,並以數量、頻率或複合指標的形式呈現,即可對公司、產業與國家等不同的對象���供適切之參考依據。本研究說明目前專利指標研究的概況,可以作為未來相關專利指標研究發展的基礎,更希望可以提供相關政策制定和產業佈局上專利指標選用之參考。 Because nowadays the patent information plays the important role of the industrial development, the patent indexes become the important reference to evaluate the patent information. This article provides the development of the patent indexes and related researches in Taiwan, and generalizes the application of classification and implication of the patent indexes. Presently the related patent index researches in Taiwan could be distinguished the patent indexes into general characteristic, the quotation and the technology and so on. Such discrimination shows the essence of the patent information and if it can compare with the factors of time and professional fields and presents in the forms of the quantity, frequency or composite indexes, it can provide the appropriate information to the company, the industry or the country. This article not only offers the understanding of the present researches of the patent indexes, but also provides the reference of the policy formulation and the industrial layout. 頁次:88-106

  15. New energy technology development related database construction survey (wind power generation); Shin energy gijutsu kaihatsu kankei data shu sakusei chosa (furyoku hatsuden)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    To arrange systematic data relating to new energy, the latest published data relating to the wind energy conversion systems have been collected and arranged. For the overview of wind energy conversion system, wind turbines with horizontal axis and vertical axis, specification of wind turbine, and conceptual figure of wind energy conversion systems are illustrated. For the installation examples, introduction development of wind energy conversion systems in the world is described for Japan, the USA, Germany, Denmark, Spain, Sweden, India, and Belgium. For the relevant legislation and support plan, relevant legislation for the introduction of wind energy conversion in Japan, support plan in Japan, and support plans in foreign countries are described. Prices of wind turbines by wind turbine makers in the world, construction cost by Japanese makers, basic term, and subsidiary company and organization are shown

  16. Data book on new energy technology development in FY 1997. Photovoltaic (PV) power generation; Shin energy gijutsu kaihatsu kankei data shu sakusei chosa. Taiyoko hatsuden

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    For the purpose of understanding the present status of photovoltaic power system (PVPS) and supporting its promotion, various data were collected. The significance of adopting PV power technology was specified for customers of various levels, such as nation, local communities, industries and individual households, to clarify the CO2 reduction effect and energy pay-back time. Data illustrate the solar cell production according to region, cell types, industries, applications, production value, and market price. Policies for PVPS in industrial countries were compared with those in Japan. Distribution of PVPS in various countries was compared with that in Japan in respect to installations and purposes of the introduction of PVPS. Financial aid programs such as subsidies, tax benefits and loans for the installation of PVPS in Japan were listed. The trend of PV-related budget of MITI was shown with every project`s description. Steps of introducing PVPS from plan to installation were depicted in the form of flow chart. Were shown measures sponsored by the government or local organizations to promote PVPS. Domestic and foreign firms related to PVPS including PV module suppliers, and PV installation contractors were listed

  17. shuō hànyŭ, nĭne? ehk Mina räägin hiina keelt, aga sina? / Piret Lakson

    Index Scriptorium Estoniae

    Lakson, Piret, 1989-

    2012-01-01

    Hiina keele õpetamisest Eestis ja Mustamäe gümnaasiumi noorest hiina keele õpetajast Wang Weist. Eesti koolidesse hiina keele õpetajate hankimine käib Tallinna ülikooli juurde loodud Konfutsiuse instituudi kaudu

  18. Survey for making a data book on the new energy technological development (photovoltaic power generation); Shin energy gijutsu kaihatsu kankei data shu sakusei chosa (taiyoko hatsuden)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    Data on the photovoltaic power generation are synthetically collected, systematized, and summarized as a data book on the photovoltaic power system. Main details are as follows: photovoltaic power systems were listed by usage, by size of power generation, and by authority concerned. Significance of adopting the photovoltaic system is stated at each level of each user of the country, local governments and individuals. As to the present situation of the solar cell market, solar cells were arranged in terms of production volume by region, production volume by type, production volume by company, shipment by usage, production amount, and price. With regard to policies of each country on the photovoltaic power system, those of advanced countries including Japan were summed up. Concerning the introduction of the system in each country, examples of the introduction were made clear, and at the same time the estimated volume of and the target for introduction of the photovoltaic power system were summarized. In respect to the subsidy system for the introduction of the photovoltaic power system, arranged were the subsidy system, the preferential tax system and the loan system.

  19. Investigation on preparing data collections related to new energy technology development. Fuel cells; Shin energy gijutsu kaihatsu kankei data shu sakusei chosa. Nenryo denchi

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    With an objective to put data related to fuel cells systematically into order, related data were collected comprehensively. Reviewing large international conferences impresses dawn of commercialization in phosphoric acid fuel cells (PAFC), take-off of megawatt-class molten carbonate fuel cells (MCFC), and remarkable advancement in studies on solid oxide fuel cells (SOFC) and polymer electrolyte fuel cells (PEFC). The data collection may be compiled as follows: basic principles, features, operation principles, system configurations, utilization fields, and characteristics were summarized on fuel cell power generation systems using phosphoric acid, polymer, molten carbonate, solid oxide, and alkaline fuel cells; major installation examples in Japan and overseas countries were summarized; investigations were given on developing other fuel cells such as alkaline type and direct methanol type fuel cells; and marketability, subsidies operations in Japan, and states of policy implementation in the U.S.A. were investigated and put into order. 22 refs., 24 figs., 21 tabs.

  20. Survey on construction of the database for new energy technology development. Cogeneration; Shin energy gijutsu kaihatsu kankei data shu sakusei chosa. Cogeneration

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    As a part of the activity promoting use of new energy, the data related to cogeneration were systematically compiled. For new energy technology, such various policies for introducing new energy are in promotion with a progress of technological development as preparation of subsidy systems, field test business, and support advisory business for introducing new energy. For further effective promotion, integral systematic compilation of various data, and arrangement as basic data are necessary. Such latest announced data in a cogeneration field were collected and compiled as outline of new energy systems, concrete applications, subsidy systems, and approaches to new energy of various countries. Main data items are as follows: trend of cogeneration, outline of system, domestic and foreign concrete applications, prediction data on the use of new energy, overview of domestic and foreign policies for cogeneration, basic terminology, and tables of main related enterprises and organizations. This database is useful for the present activities promoting use of new energy, and preparation of the future vision. 29 figs., 33 tabs.

  1. Data book on new energy technology development in FY 1997. Cogeneration; Shin energy gijutsu kaihatsu kankei data shu sakusei chosa. Cogeneration

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    Various policies are being implemented in the field of new energy technology in line with progress in technological development. Examples are about assistance mechanism, field test projects and advisory projects to support the introduction of new energy technology. In order to promote the introduction of new energy efficiently, it is necessary to compile the various information regarding new energy in a comprehensive and systematic way, and formulate a basic data set. Among various new energy technologies, cogeneration is discussed in this report. The latest published data on the respective technologies are compiled particularly regarding their overall systems, examples of introduction, assistance mechanisms and state of implementation in foreign countries. Items included in this report are the trend of cogeneration, outline of system, state of introduction, forecast of introduction, overview of policies, basic terms, and related organizations. 9 figs.

  2. Survey for making a data book related to the development of new energy technology. Cogeneration; 1999 nendo shin energy gijutsu kaihatsu kankei data shu sakusei chosa hokokusho. Cogeneration

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    This is a report of 'A data book on cogeneration' surveyed by Japan Cogeneration Center under consignment from NEDO. Together with the advance of technology development, policies of new energy technology are being developed toward the introductory promotion in terms of preparation of subsidy system, field test project, advisory project for support of new energy introduction, etc. To promote the project for introducing/promoting new energy more effectively, it is necessary to arrange various data on new energy comprehensively/systematically and to prepare it as the basic data. Out of the technical fields of new energy, this report deals with the cogeneration field and collected/arranged the most up-to-date published data in terms mainly of a list of system, actual samples of introduction, subsidy system, situation of tackling it in each country, etc. The main items of data included in this report are shown below: (1) trend of cogeneration; (2) outline of system; (3) samples of introduction in Japan and abroad; (4) forecast of introduction; (5) policies on cogeneration in Japan; (6) basic technical terms. (NEDO)

  3. Data book on new energy technology development in FY 1997. Fuel cells; Shin energy gijutsu kaihatsu kankei data shu sakusei chosa. Nenryo denchi

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    The purpose of this survey is to grasp the trends of technology development of fuel cells and their market, and to provide data required for supporting the introduction and diffusion of fuel cells. This report consists of Part 1 titled as `Trends of development of fuel cells in FY 1997`, and Part 2 titled as `Compiled data`. The Part 1 consists of three chapters, i.e., Chapter 1 titled as `Introduction`, Chapter 2 as `Development trends of fuel cells for on-site power generation`, and Chapter 3 as `Trends of development of fuel cells for mobile objects and fuel cell-powered vehicles`. The introductory chapter not only outlines the development trends but also describes the results of the 5th Grove Fuel Cell Symposium noticed as the major global international symposium on fuel cell in general and the environmental problems discussed at the COP3 Kyoto Conference, both held in TY 1997. The Part 2 contains the principles, system configurations and applications of fuel cells, PAFC, MCFC, SOFC, PEFC, modifier, DMFC, development trend of fuel cell-powered vehicles, and national policies for fuel cells in Japan. The Appendix features a report of the new technique investigation working group and information on fuel cells from newspapers. 100 refs., 4 figs.

  4. Data book on new energy technology development in FY 1997. Installations of photovoltaic (PV) power generation; Shin energy gijutsu kaihatsu kankei data shu sakusei chosa. Taiyoko hatsuden jireishu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    The present survey places particular emphasis on the field of PV power generation systems, and intends to collect data on solar cell application products and PV power generation system installation cases, to classify them according to their usage and to compile a collection of case records including photographs. For the data collection, two formats have been adopted. A format for the solar cell-based products includes a picture of the product, and information on solar cell output and commercialization status. Another format for the installation of PV power systems includes a picture of the installation, and information on location, output level, system type, PV module type, owner, and date of installation. The application of solar cells was classified into 14 fields, i.e., consumer appliances, road and traffic, railroad, general industries, housing related, automobiles, agriculture, ocean development, disaster prevention and safety, amenity, developing countries, buildings, public facilities, and environment. A total of 241 valid cases have been collected. Overseas products and installation cases are often characterized by new applications and innovative design, and contain a lot of useful suggestions for promoting the spread of PV technology in Japan

  5. Data book on new energy technology in FY 1997. Wind power generation; Shin energy gijutsu kaihatsu kankei data shu sakusei chosa. Furyoku hatsuden

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    It is an urgent necessity for Japan to promote the technological development and accelerate the introduction and diffusion of new energy. In order to diffuse and enlighten the introduction of new energy technology efficiently, it is necessary to compile various information regarding new energy in a comprehensive and systematic way, and formulate a database. Aiming at the systematic formulation of data on new energy, this survey focuses on the field of wind power generation system (WPS) and provides a collection of the latest published data on WPS, particularly regarding the worldwide installed wind power capacity, support plan and government policies, current situations of WPS market, and major technical characteristics of typical wind turbines. This report consists of the significance of wind energy, world market of wind turbines, government policies, international wind energy development, subsidies for wind energy, procedures of wind turbine system installation, governmental measures for wind energy development, subsidiary companies and organizations, basis of wind energy, and Japan`s wind energy development in 1997

  6. Clinical Efficacy of Traditional Chinese Medicine, Suan Zao Ren Tang, for Sleep Disturbance during Methadone Maintenance: A Randomized, Double-Blind, Placebo-Controlled Trial

    OpenAIRE

    Chan, Yuan-Yu; Chen, Yi-Hung; Yang, Szu-Nian; Lo, Wan-Yu; Lin, Jaung-Geng

    2015-01-01

    Methadone maintenance therapy is an effective treatment for opiate dependence, but more than three-quarters of persons receiving the treatment report sleep quality disturbances. In this double-blind, randomized, controlled trial, we recruited 90 individuals receiving methadone for at least one month who reported sleep disturbances and had Pittsburgh Sleep Quality Index (PSQI) scores > 5. The purpose of this study was to determine whether Suan Zao Ren Tang, one of the most commonly prescribed ...

  7. Suan Zao Ren Tang in Combination with Zhi Zi Chi Tang as a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

    OpenAIRE

    Hu, Lin-lin; Zhang, Xin; Liu, Wen-juan; Li, Mei; Zhang, Yong-hua

    2015-01-01

    Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT) and Zhi Zi Chi Tang (ZZCT; SZR-ZZC) for improving sleep quality and anxiety states with four indices of Polysomnography (PSG), the Insomnia Severity Index (ISI), the Pittsburgh Sleep Quality Index (PSQI), and the Self Rating Anxiety Scale (SAS). Methods. A randomized, parallel-controlled trial...

  8. Clinical Efficacy of Traditional Chinese Medicine, Suan Zao Ren Tang, for Sleep Disturbance during Methadone Maintenance: A Randomized, Double-Blind, Placebo-Controlled Trial

    Science.gov (United States)

    Chan, Yuan-Yu; Chen, Yi-Hung; Yang, Szu-Nian; Lo, Wan-Yu; Lin, Jaung-Geng

    2015-01-01

    Methadone maintenance therapy is an effective treatment for opiate dependence, but more than three-quarters of persons receiving the treatment report sleep quality disturbances. In this double-blind, randomized, controlled trial, we recruited 90 individuals receiving methadone for at least one month who reported sleep disturbances and had Pittsburgh Sleep Quality Index (PSQI) scores > 5. The purpose of this study was to determine whether Suan Zao Ren Tang, one of the most commonly prescribed traditional Chinese medications for treatment of insomnia, improves subjective sleep among methadone-maintained persons with disturbed sleep quality. Ninety patients were randomly assigned to intervention group (n = 45) and placebo group (n = 45), and all participants were analyzed. Compared with placebo treatment, Suan Zao Ren Tang treatment for four weeks produced a statistically significant improvement in the mean total PSQI scores (P = 0.007) and average sleep efficiency (P = 0.017). All adverse events (e.g., lethargy, diarrhea, and dizziness) were mild in severity. Suan Zao Ren Tang is effective for improving sleep quality and sleep efficiency among methadone-maintained patients with sleep complaints. PMID:26346534

  9. Clinical Efficacy of Traditional Chinese Medicine, Suan Zao Ren Tang, for Sleep Disturbance during Methadone Maintenance: A Randomized, Double-Blind, Placebo-Controlled Trial

    Directory of Open Access Journals (Sweden)

    Yuan-Yu Chan

    2015-01-01

    Full Text Available Methadone maintenance therapy is an effective treatment for opiate dependence, but more than three-quarters of persons receiving the treatment report sleep quality disturbances. In this double-blind, randomized, controlled trial, we recruited 90 individuals receiving methadone for at least one month who reported sleep disturbances and had Pittsburgh Sleep Quality Index (PSQI scores > 5. The purpose of this study was to determine whether Suan Zao Ren Tang, one of the most commonly prescribed traditional Chinese medications for treatment of insomnia, improves subjective sleep among methadone-maintained persons with disturbed sleep quality. Ninety patients were randomly assigned to intervention group (n=45 and placebo group (n=45, and all participants were analyzed. Compared with placebo treatment, Suan Zao Ren Tang treatment for four weeks produced a statistically significant improvement in the mean total PSQI scores (P=0.007 and average sleep efficiency (P=0.017. All adverse events (e.g., lethargy, diarrhea, and dizziness were mild in severity. Suan Zao Ren Tang is effective for improving sleep quality and sleep efficiency among methadone-maintained patients with sleep complaints.

  10. Suan Zao Ren Tang as an Original Treatment for Sleep Difficulty in Climacteric Women: A Prospective Clinical Observation

    Science.gov (United States)

    Yeh, Chia-Hao; Arnold, Christof K.; Chen, Yen-Hui; Lai, Jung-Nein

    2011-01-01

    Little scientific evidence supports the efficacy of herbal medicines in the treatment of women with sleep difficulty during the climacteric period. The purpose of this study is to evaluate the efficacy and safety of Suan Zao Ren Tang (SZRT) in reducing the impact of sleep disturbance on climacteric women, as measured by Pittsburg sleep quality index (PSQI) and the World Health Organization quality of life (WHOQOL). Sixty-seven climacteric women with sleep difficulty intending to treat received SZRT at a rate of 4.0 g, thrice daily for four weeks (MRS < 16, n = 34; MRS ≥ 16, n = 33). After taking into account potential confounding factors, the mean PSQI total scores had fallen from 13.0 (±2.9) to 9.0 (±3.2) (95% confidence interval −4.93, −3.10). Further analyses showed that SZRT produced superior benefit of daytime dysfunction in women with severe menopausal symptoms (MRS ≥ 16). There were three of the withdrawals involved treatment-related adverse events (stomachache, diarrhea, and dizziness). Excluding women with a past history of stomachache, diarrhea, or dizziness, four weeks of therapy with SZRT appears to be a relatively safe and effective short-term therapeutic option in improving daytime function of climacteric women with poor sleep quality. PMID:21660310

  11. Suan Zao Ren Tang as an Original Treatment for Sleep Difficulty in Climacteric Women: A Prospective Clinical Observation

    Directory of Open Access Journals (Sweden)

    Chia-Hao Yeh

    2011-01-01

    Full Text Available Little scientific evidence supports the efficacy of herbal medicines in the treatment of women with sleep difficulty during the climacteric period. The purpose of this study is to evaluate the efficacy and safety of Suan Zao Ren Tang (SZRT in reducing the impact of sleep disturbance on climacteric women, as measured by Pittsburg sleep quality index (PSQI and the World Health Organization quality of life (WHOQOL. Sixty-seven climacteric women with sleep difficulty intending to treat received SZRT at a rate of 4.0 g, thrice daily for four weeks (MRS<16, n=34; MRS≥16, n=33. After taking into account potential confounding factors, the mean PSQI total scores had fallen from 13.0 (±2.9 to 9.0 (±3.2 (95% confidence interval −4.93, −3.10. Further analyses showed that SZRT produced superior benefit of daytime dysfunction in women with severe menopausal symptoms (MRS≥16. There were three of the withdrawals involved treatment-related adverse events (stomachache, diarrhea, and dizziness. Excluding women with a past history of stomachache, diarrhea, or dizziness, four weeks of therapy with SZRT appears to be a relatively safe and effective short-term therapeutic option in improving daytime function of climacteric women with poor sleep quality.

  12. Sources of Water Supply and Water Quality for Local Consumption: The Case Study of Eco-Tourism Village, Suan Luang Sub- District Municipality, Ampawa District, Samut Songkram Province, Thailand

    OpenAIRE

    Paiboon Jeamponk; Tasanee Ponglaa; Patchapon Srisanguan

    2014-01-01

    The aim of this research paper was based on an examination of sources of water supply and water quality for local consumption, conducted at eco- tourism villages of Suan Luang Sub- District Municipality of Amphawa District, Samut Songkram Province. The study incorporated both questionnaire and field work of water testing as the research tool and method. The sample size of 288 households was based on the population of the district, whereas the selected sample water sources were from 60 househo...

  13. Identification and analysis of chemical constituents and rat serum metabolites in Suan-Zao-Ren granule using ultra high performance liquid chromatography quadrupole time-of-flight mass spectrometry combined with multiple data processing approaches.

    Science.gov (United States)

    Du, Yiyang; He, Bosai; Li, Qing; He, Jiao; Wang, Di; Bi, Kaishun

    2017-07-01

    Suan-Zao-Ren granule is widely used to treat insomnia in China. However, because of the complexity and diversity of the chemical compositions in traditional Chinese medicine formula, the comprehensive analysis of constituents in vitro and in vivo is rather difficult. In our study, an ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry and the PeakView® software, which uses multiple data processing approaches including product ion filter, neutral loss filter, and mass defect filter, method was developed to characterize the ingredients and rat serum metabolites in Suan-Zao-Ren granule. A total of 101 constituents were detected in vitro. Under the same analysis conditions, 68 constituents were characterized in rat serum, including 35 prototype components and 33 metabolites. The metabolic pathways of main components were also illustrated. Among them, the metabolic pathways of timosaponin AI were firstly revealed. The bioactive compounds mainly underwent the phase I metabolic pathways including hydroxylation, oxidation, hydrolysis, and phase II metabolic pathways including sulfate conjugation, glucuronide conjugation, cysteine conjugation, acetycysteine conjugation, and glutathione conjugation. In conclusion, our results showed that this analysis approach was extremely useful for the in-depth pharmacological research of Suan-Zao-Ren granule and provided a chemical basis for its rational. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Suan Zao Ren Tang in Combination with Zhi Zi Chi Tang as a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

    Science.gov (United States)

    Hu, Lin-lin; Zhang, Xin; Liu, Wen-juan; Li, Mei; Zhang, Yong-hua

    2015-01-01

    Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT) and Zhi Zi Chi Tang (ZZCT; SZR-ZZC) for improving sleep quality and anxiety states with four indices of Polysomnography (PSG), the Insomnia Severity Index (ISI), the Pittsburgh Sleep Quality Index (PSQI), and the Self Rating Anxiety Scale (SAS). Methods. A randomized, parallel-controlled trial compared SZR-ZZC to lorazepam tablet in insomniacs with anxiety. Patients were randomized to the SZR-ZZC treatment group (n = 60) and the lorazepam tablet treatment group (n = 59). Results. SZR-ZZC significantly improved scores on all four treatment indices. Compared with lorazepam, treatment with SZR-ZZC resulted in a significant reduction in the ISI (P = 0.029), the PSQI (P = 0.017), and wake after sleep onset (WASO; P = 0.008) scores and improved sleep architecture (P = 0.000–0.003) after a 4-week treatment period. Only one subject in the SZR-ZZC group experienced adverse side effects. Conclusion. Treatment with SZR-ZZC for 4 weeks appears to be a relatively safe and effective complementary therapeutic option when aiming to improve sleep quality and anxiety in insomniacs with anxiety. PMID:25793006

  15. Suan Zao Ren Tang in Combination with Zhi Zi Chi Tang as a Treatment Protocol for Insomniacs with Anxiety: A Randomized Parallel-Controlled Trial

    Directory of Open Access Journals (Sweden)

    Lin-lin Hu

    2015-01-01

    Full Text Available Insomnia is a serious worldwide health problem that is often comorbid with anxiety. The purpose of the present study was to evaluate the efficacy of a Chinese formula containing Suan Zao Ren Tang (SZRT and Zhi Zi Chi Tang (ZZCT; SZR-ZZC for improving sleep quality and anxiety states with four indices of Polysomnography (PSG, the Insomnia Severity Index (ISI, the Pittsburgh Sleep Quality Index (PSQI, and the Self Rating Anxiety Scale (SAS. Methods. A randomized, parallel-controlled trial compared SZR-ZZC to lorazepam tablet in insomniacs with anxiety. Patients were randomized to the SZR-ZZC treatment group (n=60 and the lorazepam tablet treatment group (n=59. Results. SZR-ZZC significantly improved scores on all four treatment indices. Compared with lorazepam, treatment with SZR-ZZC resulted in a significant reduction in the ISI (P=0.029, the PSQI (P=0.017, and wake after sleep onset (WASO; P=0.008 scores and improved sleep architecture (P=0.000–0.003 after a 4-week treatment period. Only one subject in the SZR-ZZC group experienced adverse side effects. Conclusion. Treatment with SZR-ZZC for 4 weeks appears to be a relatively safe and effective complementary therapeutic option when aiming to improve sleep quality and anxiety in insomniacs with anxiety.

  16. Electricity and Water Supply Consumption and Greenhouse Gas Emission at the Office of the Faculty of Science and Technology, Suan Sunandha Rajabhat University

    Directory of Open Access Journals (Sweden)

    Ronbanchob Apiratikul

    2015-07-01

    Full Text Available This work was a data collection of electricity and water supply consumption of the Dean’s Office of the Faculty of Science and Technology, Suan Sunandha Rajabhat University, Thailand. The greenhouse gas emissions from electricity and water supply consumptions were calculated using the up-to-date emission factor from the Thailand Greenhouse Gas Management Organization (TGO database. In average, the office consumes 1.045 m3 /d and 87.9 kWh/d of water and electricity, respectively. This is equal to 68.5 Liter per person (11.25 L/m2 and 4.1 kWh per person (0.6788 kWh /m2 for the daily water supply and electricity consumptions, respectively. The total daily greenhouse gas emission from both electricity and water supply consumption is 59.01 kg-CO2 eq. which is mainly came from the electricity consumption (≈ 98%. The average emission based on people and area are 2.566 kg-CO2 eq per person and 0.422 kg-CO2/m2 , respectively.

  17. Survey for making a data book related to the development of new energy technology (the photovoltaic power generation); Shin energy gijutsu kaihatsu kankei data shu sakusei chosa (taiyoko hatsuden)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    A data book related to the photovoltaic power generation was made as a part of the systematical preparation of new energy related data. The paper arranged the importance of introducing the photovoltaic power system and the CO2 reduction effect at levels such as the government, local government, industries and individuals which are users. Described were the production quantity by region/type/company, shipment by usage, production amount and prices of solar cells. Arranged was the situation of policies on the photovoltaic power generation in Japan and developed countries. Examples of the introduction in countries including Japan were examined to know the introduction quantity and target. The paper introduced the subsidy system, preferential tax system and loan system for the introduction of the photovoltaic power system in Japan. The flow was summed up from the planning of the system introduction to the installation. The status of handling with the system introduction of government related organs and local governments was stated. The paper showed a list of the companies related to the photovoltaic power system and the references of solar cell makers and solar system installation makers. The development is so quickly made that the renewal every year of the system and the quality enhancement are required. 32 figs., 112 tabs.

  18. Research report for fiscal 1998. Basic research for promoting joint implementation, etc. (master plan for changing district heating boilers, Nizhniy Novgorod province); 1998 nendo chosa hokokusho. Nizhniy Novgorod shu chiiki danboyo boiler tenkan master plan

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    The above-named plan aims to reduce greenhouse gas emissions and enhance energy efficiency. The above-named Russian system for supplying heat and hot water is operated by the 51 local governments in the province, with boiler houses sited at 4047 locations. Almost all of them are approximately 30 years old, low in thermal efficiency because of their obsolete design and structure, costly because of their old parts and components wanting repair, and higher in fuel cost than those fired by natural gas. It is indispensable to replace the existing boilers with natural gas-fired boilers, and it is estimated that there are 4511 boilers that require such replacement. When the heat supply business operated by the local governments is modernized, the CO2 gas emission will be reduced by approximately 2.675-million tons/year. As for energy efficiency, it is found that replacement by heavy oil-fired boilers is the highest in terms of the effect of investment. (NEDO)

  19. Survey for making a data book related to the development of new energy technology. Wind power generation; 1999 nendo shin energy gijjtsu kaihatsu kankei data shu sakusei chosa hokokusho. Furyoku hatsuden

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    For the purpose of systematically arranging the data on new energy, this paper focused on the wind power system and collected/arranged the most up-to-date published data on the wind power system, mostly in terms of samples of introduction in Japan and abroad, supporting plans and policies, market of the wind power system, specifications for the main wind turbines, etc. This report included the following: (1) Quantity of introduction of wind power system. (2) Targeted quantity of introduction of wind power system in Japan and abroad. (3) Policies on wind power system in Japan and abroad. (4) Sales of wind power system. (5) Cost of introduction of wind power system. (6) Effects of introduction of wind power generation. (7) Trend of technology development/subjects on technology development/problems on introductory promotion. (8) Outline of wind power system. (9) Predominant trends of wind power generation in Japan. (10) List of the persons to contact enterprises related to wind power generation. (11) Quantity of wind energy existing in Japan. (12) Specifications for wind turbine by power generation scale. (13) Method to calculate power generation cost of wind power system. (14) Explanation of basic technical terms. (15) List of the related rules as to introduction of wind power generation. (16) Publications relating to wind power generation. (NEDO)

  20. Report on the FY 1998 geological structure survey. North Hay Gulch area, State of Colorado, the U.S.; 1998 nendo kaigaitan kaihatsu kanosei chosa hojo jigyo chishitsu kozo chosa hokokusho. Beikoku Colorado shu North Hay Gulch chiiki

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-02-01

    Test boring at 21 places and core sampling were conducted during September-November 1998 along the ridge to the west of Hay Gulch and in the direction crossing the northwest of the drainage canal and National King Coal Mine (NKC coal mine). It was found that A layer which NKC coal mine is now drilling is the upper part of A coal seam where the seam bifurcates. The boundary to the west of the thick A coal seam is not clear, and there is a possibility that more reserve from the thick coal seam and single seam exists toward Cherry Creek. In the existing coal drilling area, the lower A seam existing under the upper A seam becomes thin rapidly, and the seam thickness becomes less than 1 foot. The average thickness of thick coal seams is 9.9 feet, and the area is 780 acres along the ridge. The upper A coal seam except the above is 5.5 feet in average seam thickness and 910 acres in area. The reserve is 23 million tons. As to the quality of thick coal seam, the average heating value is 7,089 kcal/kg, sulfur content 0.68%, and ash content 7.50%. As coal drilling conditions, the same level as or higher than those of NKC coal mine is expected. (NEDO)

  1. FY1998 research report on the basic research on geothermal district heating in Kamchatka, Russia; 1998 nendo Roshia Renpo Kamchatka shu ni okeru chinetsu riyo ni yoru chiiki danbo ni kansuru kiso chosa hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-05-01

    Petropavlovsk-Kamchatky (P-K) city in Kamchatka, Russia is operating hot-water district heating using heavy oil boilers and waste hot water of thermal power plants as heat sources. Feasibility study was made on district heating using natural geothermal hot water and/or geothermal heat pump systems as heat sources of hot water supply for reduction of greenhouse effect gas emission. Among 3 areas including geothermal hot water, use of hot water in K area was impossible because of lower temperature and less spring water. Use of hot water in P and UP areas was impossible as primary hot water because of temperature drop to 64 degrees C during hot water supply toward P-K city. The building heating operation test was carried out using the geothermal heat pump system installed in a newly drilled heat exchange well of 100m deep. As a result, sufficient heat recovery was achieved for heating. If all of 49 boiler houses for heating are replaced with such geothermal heat pump systems, CO{sub 2} reduction was estimated to be 520,000t/y. (NEDO)

  2. FY 1998 annual report on the compilation of the data related to new energy technology development. Photovoltaic power generation; 1998 nendo shin energy gijutsu kaihatsu kankei data shu sakusei chosa hokokusho. Taiyoko hatsuden

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    The data, centered by those related to generation of photovoltaic (PV) power as one branch of new energy, are collected and systematically compiled under the following fields. (Significance of adopting PV power systems) describes, e.g., CO2 reduction effect and energy pay-back time for different customers, i.e., nation, local governments, industries and individual households. (Present status of solar cell markets) describes solar cell production by region, cell technology and industry; shipments by application; production values; and prices. (PV system policies overseas) compares the policies of the industrialized countries for PV power systems with those of Japan. (Introduction of PV power systems overseas) compares situations of various countries in PV power system introduction with those of Japan with respect to estimated quantities of PV systems installed and target quantities. (Financial supports for PV power system installation) describes subsidies, tax benefits and loans adopted in Japan. Other items covered herein include transition of PV-related budgets, flow of PV system introduction, measures taken by central and local governments, and contacts for PV-related enterprises. (NEDO)

  3. Survey for making a data book related to the development of new energy technology. Fuel cell; 1999 nendo shin energy gijutsu kaihatsu kankei data shu sakusei chosa hokokusho. Nenryo denchi

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    To proceed with the systematical arrangement of the new energy related data, this survey collected the data relating to fuel cells, and systematized them with the aim of making a data book related to fuel cells. Further, fuel cells are still developing, and therefore, the trend of development in this one year was roughly seen to make it the data toward the future development. This data book is composed of Part 1 (the world development trend in FY 1999) and Part 2 (data book). Part 1 was divided into the fixed power system (Chapter 1), fuel cell vehicle (Chapter 2), and selection of fuel (Chapter 3). The book has a big feature that the selection of fuel was added as an individual chapter, which is a difference from that of FY 1998. In the description of the developmental trend of fuel cell vehicle (FCV) in Chapter 2, the results of the present development and the trend were described in line with the subjects in achieving the commercialization of FCV. Part 2 is a data book which indicates the state of technology development of each of various fuel cells such as actual results of the demonstrative operation of fuel cells in Japan and abroad. (NEDO)

  4. Observation of the Clinical Effect on Acute Ankle Sprain Treated with Shu-jin Huoxue Decoction%舒筋活血汤治疗急性踝关节扭伤临床效果观察

    Institute of Scientific and Technical Information of China (English)

    党芙蓉; 张晓娜

    2015-01-01

    Objective To analyze the clinical efficacy of shujin huoxue decoction on acute ankle sprain. Methods Ninety - eight patients of acute ankle sprain were collected from January 2011 to January 2013 and were randomized into two groups. In the control group,48 cases were treated with local cold com-press and bandage fixation. In the trial group,on the basis of the treatment as the control group,shujin huoxue decoction was added for oral administration. TCM main symptoms,VAS score,Takakura function score and ankle sprain index(ASI)were compared before and 2 weeks after treatment in two groups. The clinical total effective rate was compared between the two groups 2 weeks after treatment. Results The scores of joint pain,motor impairment,joint swelling,joint redness and joint tenderness 2 weeks after treatment were de-creased significantly as compared with those before treatment in the individual group. Those scores in the trial group were decreased significantly than those in the control group 2 weeks after treatment(P ﹤ 0. 05). VAS score and ASI score were decreased significantly 2 weeks after treatment as compared with those before treat-ment in the two groups. Takakura score was increased significantly as compared with that before treatment(P﹤ 0. 05). The total effective rate in the trial group was higher significantly than that in the control group 2 weeks after treatment( P ﹤ 0. 05). Conclusion On the basic treatment of traditional cold compress and bandage fixation,the supplemented shujin huoxue decoction effectively relieves the clinical symptoms of acute ankle sprain and improves the life quality in the patients.%目的:分析舒筋活血汤治疗急性踝关节扭伤的临床疗效。方法选取2011年1月至2013年1月98例急性踝关节扭伤患者,随机分为两组。对照组48例予以局部冷敷和绷带固定,试验组在对照组治疗的基础上,加用舒筋活血汤口服。比较治疗前和治疗2周后两组患者的中医主要症状、疼痛视觉模拟标尺法评分(VAS 评分)、Takakura 功能评分和踝关节扭伤症状(ASI)积分。比较治疗2周后两组患者的临床总有效率。结果治疗前和治疗2周后两组病例关节疼痛、活动障碍、关节肿胀、关节红热和关节压痛评分较本组治疗前显著降低( P ﹤0.05);治疗2周后试验组的关节疼痛、活动障碍、关节肿胀、关节红热和关节压痛评分较对照组治疗后显著降低(P ﹤0.05)。治疗2周后两组病例的 VAS 疼痛评分和 ASI 评分较治疗前显著降低(P ﹤0.05),Takakura 功能评分较治疗前显著升高(P ﹤0.05);治疗2周后试验组的 VAS 疼痛评分和 ASI 评分较对照组治疗后显著降低( P ﹤0.05),Takakura 功能评分显著升高(P ﹤0.05)。试验组治疗2周后的总有效率显著高于对照组(P ﹤0.05)。结论在传统冷敷和绷带固定基础上,加用舒筋活血汤,可有效缓解急性踝关节扭伤患者的临床症状,改善其生活质量。

  5. Fiscal 1985 research report. Feasibility study on overseas coal mine development (La Loma coal field, Cesar province, Columbia); 1985 nendo kaigaitan kaihatsu kanosei chosa hokokusho. Columbia Censar shu La Loma tanden

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-01

    Tomen Corp. was proposed in April 1985 to join in the additional exploration of La Loma mine lot in 1986 through Greenley Co. in America, one of the members of Siminera- Greenley Association which has promoted the survey and exploration of La Loma coal mine lot (20,000ha), Cesar province, Columbia since 1979. In answer to this proposal, Tomen obtained the fiscal 1985 feasibility study subsidy for foreign coal development, and made surveys on the coal seam, coal property, coal deposit, recoverable deposit and profitability of La Loma coal field including La Loma coal mine lot, and further surveys on infrastructure improvement for the future coal development, the policy of Columbian government and various laws concerned. Based on the above survey results, for assessment of this coal field, Tomen Corp. made field survey on the coal field and infrastructures, document collection and hearing from Columbian and U.S. governments and companies, further collection of other documents concerned and information, and analysis of the survey results. As a result, the assessment of La Loma coal field was completed. (NEDO)

  6. Fiscal 1999 research report. Data collection for development of new energy technology (Photovoltaic power generation); 1999 nendo shin energy gijutsu kaihatsu kankei data shu sakusei chosa (taiyoko hatsuden) hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    As a part of systematic data preparations on new energy technology, this research aims at collection and analysis of data on domestic and overseas applications, diffusion targets, concrete examples, policies, laws, subsidy systems, and the latest technology development trends of photovoltaic power generation, and at preparation of its basic data through integration and systematization of the collected data. The research items are as follows: domestic and overseas applications, diffusion targets, concrete examples, policies, laws, subsidy systems, productions of solar cells, typical photovoltaic power generation costs, trial calculations of CO{sub 2} reduction in photovoltaic power generation, technology development trends, technology development issues, issues for faster diffusion, configurations and conceptual charts of photovoltaic power systems, and major domestic and overseas trends. As a supplement, domestic and overseas manufacturers of solar cells, and manufacturers of photovoltaic power systems are listed with their addresses. The solar cell production capacities of major countries are also arranged. (NEDO)

  7. Fiscal 1998 research report. Survey on data collection for development of new energy technology (fuel cell); 1998 nendo chosa hokokusho. Shin energy gijutsu kaihatsu kankei data shu sakusei chosa (nenryo denchi)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    This report is composed of Part 1: the development trend of fuel cells in fiscal 1998, and Part 2: the collected data and appendices. Part 1 includes 4 chapters, (1) The outline of the development trend, (2) Stationary fuel cell, (3) The development trend of fuel cell vehicles, and (4) The development trend of small transportable fuel cells. The report newly includes the development trend of small-capacity fuel cells and the report on 1998 Fuel Cell Seminar notable as an international conference on fuel cell summarizing the trend of fuel cells in fiscal 1998, as compared with the fiscal 1997 report. Part 2 is the collected data on domestic and foreign demonstration operation results of fuel cells, and technical development of every fuel cell. In addition to various collected data on the whole of fuel cells and their use techniques, Part 2 includes the principle, features, system configuration, performance simulation technique, application and market analysis of fuel cells, and the national policy and concerned laws on a subsidy system for introduction of fuel cells, for example. (NEDO)

  8. FY1998 survey on preparation of data collection related to new energy technology development (cogeneration); 1998 nendo shin energy gijutsu kaihatsu kankei data shu sakusei chosa (cogeneration) chosa hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    New energy technologies have had the subsidy institutions established in association with advancement of the technologies, and such introduction promoting measures developed as the introduction assistance and advisory project. To promote this development more effectively, it is necessary that different data related to new energies are put into order comprehensively and systematically to be retained as the basic data. Therefore, this paper collects and puts into order the latest published data on cogeneration from among other new energy technology areas, with main regard to system listing, specific introduction examples, subsidy institutions, and how other countries are working on the technologies. Hydroelectric power generation uses up head energy of water by installing power plants along a river from higher location to lower location. Similarly the cogeneration is a kind of multi-stage energy utilization (cascade utilization) system that uses up energy serially from as high oil and natural gas combustion temperature as 1,500 degrees C or higher down to temperature levels used for hot water supply and air conditioning as low as 45 to 50 degrees C. It generates electric power by using a thermal engine, and utilizes waste heat effectively. (NEDO)

  9. 專論/大學社群之共同故事萃取研究/阮明淑 | The Study on Extraction of Common Organizational Story within University Community / Ming-Shu Yuan

    Directory of Open Access Journals (Sweden)

    阮明淑 Ming-Shu Yuan

    2007-10-01

    Full Text Available

    說故事(storytelling為人類傳承文化及智慧的一種方式。在組織中,透過說故事能有效的轉移內隱知識,促進組織內外的溝通及學習,並有 助於組織價值的建立。大學是創新知識的重要來源之一,在知識經濟時代中佔有重要地位,若能善加利用說故事之方式,必能更有效傳播大學之理念、精神與文化。 因此本研究以世新大學為個案研究,使用深度訪談法萃取大學社群之組織共同故事,及共同故事對社群成員的意義與價值。研究結果歸納出六類世新大學之組織共同 故事,而其中,創辦人對於世新大學組織中之資深教職員影響深遠。

    Storytelling is a way of passing on wisdom and culture. In an organization, storytelling can transfer tacit knowledge effectively, improve communication and learning among members, and create organization value. Universities are important resources of innovative knowledge in the age of knowledge-based economy. The idea, spirit, and culture of universities can be conveyed effectively by storytelling. Based on the in-depth interviews, this study extracts common stories within university community and the meaning and value of those stories. Shih Hsin university is the survey object in this study. The result indicates that there are 6 types of common story in Shih Hsin University. furthermore, the common story about the founder of the institute has the greatest influence in the organization.

    頁次:64-80

  10. Survey report for fiscal 1998 on the survey on preparation of data collection related to new energy technology development (wind power generation ); 1998 nendo shin energy gijutsu kaihatsu kankei data shu sakusei chosa (furyoku hatsuden) chosa hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    As a result of heightening consciousness on assurance of energy security and global environment problems in recent years, it is urged in Japan to promote development of technologies to introduce and proliferate new energies, and work on acceleration of the introduction. On the other hand, in order to move forward effectively the introduction promoting project intended of proliferation and enlightenment, it is necessary to put into order comprehensively and systematically the different data on the new energies, and summarize them as the basic data. This report, focusing on a wind power generation system, collects and puts into order the latest published data on the wind power generation system, placing in the center the introduction examples in Japan and other countries, supporting measures, wind power generation system markets, and the specifications of major windmills. The major contents may be summarized as follows: significance of introducing the wind power generation system, the current status of the market, policies in different countries, status of introducing the system in other countries, subsidy institutions for the introduction, the introduction flow, efforts made by government related organizations and local governments, a list of window offices of the related corporations, the fundamental knowledge, and the movements in 1998. (NEDO)

  11. Report on the FY 1987 potential survey of overseas coal development. Nanaimo coal field, Vancouver island, State of British Columbia, Canada; 1987 nendo kaigaitan kaihatsu kanosei chosa hokokusho. Canada British Columbia shu Vancouver to Nanaimo tanden

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-03-01

    In Vancouver island, coal deposits which are economically minable can be found only in Comox sub-basin and Nanaimo sub-basin. In the Nanaimo coal field, 110 coal deposits have been operated, and a total of 54.39 million MT coal was drilled and shipped. The coal reserve of approximately 90 million MT seems to be still left, but it is hard to know how much the minable coal is in the case only of within 300m below earth's surface. In the Comox coal field, there seems to be still left the coal reserve as much as approximately 1.3 billion MT. The coal of the Nanaimo coal field is ranked as high volatile 'A' bituminous, the same as the coal of the Comox coal field. In the Wolf Mountain coal mining area, there is the minable coal of approximately 2.4 million MT in the undeveloped portion. The clean coal to be produced came to be regarded as good for shipment to Japan not only as steam coal but as slightly caking coal if it is competitive in cost as viewed from the coal quality expected. (NEDO)

  12. Effect of metal ion species on mechanical relaxation of ethylene-co-methacrylic acid based ionomers; Ethylene-metakuriru san ionomer no rikigaku kanwa ni oyobosu kinzoku ion shu no eikyo

    Energy Technology Data Exchange (ETDEWEB)

    Zeng, X; Araki, O; Takigawa, T; Masuda, T [Kyoto University, Kyoto (Japan); Takahashi, M [Kyoto Institute of Technology, Kyoto (Japan)

    1996-12-15

    Dynamic viscoelasticity of ethylene-co-methacrylic acid (EMAA) based ionomers containing Zn or Na as well as EMAA was investigated. The film samples used for viscoelasticity measurements were molded at 195{degree}C. Two kinds of specimens, quenched and slowly cooled samples after molding, were prepared for each polymer specimen. For the quenched samples, the effect of aging on dynamic viscoelasticity was also examined. The temperature dispersion curves of dynamic storage modulus (E{prime}) of the ionomers obtained by quenching showed a large decrease around 35{degree}C due to the glass transition of EMAA ionomers. The ionomers prepared by slow cooling showed a high value of E{prime} in the high temperature region, compared with the quenched samples. This may be due to the difference in the degree of ionic cluster formation in the ionomers. The values of E{prime} at low temperatures increased with aging time for the quenched samples, which originates from the equilibration of the glassy state by aging. 14 refs., 7 figs., 1 tab.

  13. Never Die Alone: Death and Birth in Pure Land Buddhism : Jonathan Watts and Yoshiharu Tomatsu, editors, 2008, Jodo Shu Press (Tokyo, 978-4-883-63041-7, 175 pp.).

    Science.gov (United States)

    Maymind, Ilana

    2017-09-01

    This is a review of a collection of six essays. These essays, with the exception of one, are written by the followers of Shin Buddhism (Pure Land Buddhism). The last essay in this collection is written from the perspective of Theravada Buddhism rather than Mahayana Buddhism. This collection is a result of the initiative by Rev. Yoshiharu Tomatsu who, as a Buddhist priest, has acquired hands-on experience in dealing with grieving Temple members and became acutely aware of the discrepancy between a medical system and a ritualistic Buddhist system. While a medical system overlooks the spiritual needs of the dying, a Buddhist temple system neglects the spiritual needs of the living. This book ensued from a project that was initiated in 2006 and focused on the above-mentioned missing links, aiming to bring into conversation medical and religious practitioners.

  14. Report on the FY 1987 potential survey of overseas coal development. Nanaimo coal field, Vancouver island, State of British Columbia, Canada; 1987 nendo kaigaitan kaihatsu kanosei chosa hokokusho. Canada British Columbia shu Vancouver to Nanaimo tanden

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-03-01

    In Vancouver island, coal deposits which are economically minable can be found only in Comox sub-basin and Nanaimo sub-basin. In the Nanaimo coal field, 110 coal deposits have been operated, and a total of 54.39 million MT coal was drilled and shipped. The coal reserve of approximately 90 million MT seems to be still left, but it is hard to know how much the minable coal is in the case only of within 300m below earth's surface. In the Comox coal field, there seems to be still left the coal reserve as much as approximately 1.3 billion MT. The coal of the Nanaimo coal field is ranked as high volatile 'A' bituminous, the same as the coal of the Comox coal field. In the Wolf Mountain coal mining area, there is the minable coal of approximately 2.4 million MT in the undeveloped portion. The clean coal to be produced came to be regarded as good for shipment to Japan not only as steam coal but as slightly caking coal if it is competitive in cost as viewed from the coal quality expected. (NEDO)

  15. Purification and Characterization of Plantaricin JLA-9: A Novel Bacteriocin against Bacillus spp. Produced by Lactobacillus plantarum JLA-9 from Suan-Tsai, a Traditional Chinese Fermented Cabbage.

    Science.gov (United States)

    Zhao, Shengming; Han, Jinzhi; Bie, Xiaomei; Lu, Zhaoxin; Zhang, Chong; Lv, Fengxia

    2016-04-06

    Bacteriocins are ribosomally synthesized peptides with antimicrobial activity produced by numerous bacteria. A novel bacteriocin-producing strain, Lactobacillus plantarum JLA-9, isolated from Suan-Tsai, a traditional Chinese fermented cabbage, was screened and identified by its physiobiochemical characteristics and 16S rDNA sequence analysis. A new bacteriocin, designated plantaricin JLA-9, was purified using butanol extraction, gel filtration, and reverse-phase high-performance liquid chromatography. The molecular mass of plantaricin JLA-9 was shown to be 1044 Da by MALDI-TOF-MS analyses. The amino acid sequence of plantaricin JLA-9 was predicted to be FWQKMSFA by MALDI-TOF-MS/MS, which was confirmed by Edman degradation. This bacteriocin exhibited broad-spectrum antibacterial activity against Gram-positive and Gram-negative bacteria, especially Bacillus spp., high thermal stability (20 min, 121 °C), and narrow pH stability (pH 2.0-7.0). It was sensitive to α-chymotrypsin, pepsin, alkaline protease, and papain. The mode of action of this bacteriocin responsible for outgrowth inhibition of Bacillus cereus spores was studied. Plantaricin JLA-9 had no detectable effects on germination initiation over 1 h on monitoring the hydration, heat resistance, and 2,6-pyridinedicarboxylic acid (DPA) release of spores. Rather, germination initiation is a prerequisite for the action of plantaricin JLA-9. Plantaricin JLA-9 inhibited growth by preventing the establishment of oxidative metabolism and disrupting membrane integrity in germinating spores within 2 h. The results suggest that plantaricin JLA-9 has potential applications in the control of Bacillus spp. in the food industry.

  16. Survey on improvement in development of coal in Asia-Pacific region in fiscal 1998. Survey on optimization of coal transportation system in Kalimantan, Indonesia (South Kalimantan State); 1998 nendo Asia Taiheiyo sekitan kaihatsu kodoka chosa. Indonesia Karimantan ni okeru sekitan yuso system saitekika chosa (Minami Karimantan shu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    Based on the June 1998 agreement with Indonesia on a comprehensive survey of the Kalimantan coal transportation system, plans for developing transportation infrastructures and coal mines were established, and a survey was carried out to realize efficient coal development and transportation. In proceeding with the future development of the South Kalimantan coal, it was made clear that the domestic Indonesian demand and export demand thereon can be fully expected, and latent supply capability thereto exists sufficiently. However, although the latent supply capability is available, the coal transportation infrastructures are insufficient, hence new construction of railways and coal shipping ports is necessary. The present survey has prepared an LP model for the coal transportation infrastructures, and performed case studies on six coal transportation scenarios composed of potential existing or new roads, waterways, railways and coal shipping ports. It was found promising economically that, for either case of domestic or export supply, Tg. Selatan port shall be newly built in addition to IBT port and NPLCT port, to link the ports by a railway network to be built newly. (NEDO)

  17. Survey for preparing the database for R and D of new engines. Waste power generation, solar heat system, geothermal power generation, clean energy vehicle, coal liquefaction/gasification, and combined systems; Shin energy gijutsu kaihatsu kankei data shu sakusei chosa. Haikibutsu hatsuden, taiyonetsu riyo, chinetsu hatsuden, clean energy jidosha, sekitan ekika gas ka oyobi odanteki tema

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    The present developmental conditions and issues of new energies are systematically arranged for effective promotion of their diffusion. One hundred and forty six general waste power generation facilities of 558,000kW are in operation in 1995, and among them 89 facilities supplies 1,080 GWh to power companies. 50 industrial waste power facilities of 247,000kW are in operation. 20,000 solar systems and 180,000 hot water heaters are in operation in 1995. Commercial geothermal power generation facilities of 490,000kW and private ones of 36,000kW are in operation. Introduction of expensive clean energy vehicles is making very slow progress. The pilot study on bituminous coal liquefaction is in promotion mainly by NEDO. The experiment of entrained bed coal gasification in Nakoso was successfully completed, and development of a commercial plant is to be expected. Power rates of 10 power companies were reduced in 1996, and unit purchase prices of surplus power of photovoltaic and wind power generation were also revised. The new menu and unit purchase price were announced in 1996 for surplus power of waste power generation and fuel cell. 67 figs., 284 tabs.

  18. Investigation cost subsidizing project for improving development of overseas coals in fiscal 1999. Investigations on improving development of Asian and Pacific coals (Investigation on optimizing the coal transportation system in East Karimantan Province in Indonesia); 1999 nendo Asia Taiheiyo sekitan kaihatsu kodoka chosa. Indonesia Higashi Karimantan shu ni okeru sekitan yuso system saitekika chosa

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    Evaluation was given on coal production quantity and coal transportation capability in areas scheduled of future development in Karimantan, Indonesia. Discussions were given on an optimal coal transportation system in East Karimantan Province. The coal production quantity in East Karimantan in fiscal 1999 was 35.27 million tons, accounting for 48% of the total Indonesian coal production. Production of 81.90 million tons is anticipated in 2020. Quality of the coal being produced is low in ash and high in water content in general. Calorific power is 5800 kcal or more. Sulfur content is 0.5% or more, not necessarily a low sulfur coal. The result of analyzing the optimal transportation routes by using the LP model may be summarized as follows: such scenarios are regarded to be largely profitable and advantageous that assume making railways utilizable as the land transportation in addition to use of trucks, belt conveyers, and barges, expanding coal terminals at the ports of PBCT, KPC, BCT and NPLCT, and newly building ports at Tarakan, TgSengatta, BPCTH, and Mangkapadie. (NEDO)

  19. Fiscal 1997 report on the survey for a data book on new energy technology development. Waste power generation, solar energy utilization. geothermal power generation, clean energy vehicles, coal liquefaction/gasification, and traverse themes; 1997 nendo chosa hokokusho. Shin energy gijutsu kaihatsu kankei data shu sakusei chosa (haikibutsu hatsuden, taiyonetsu riyo, chinetsu hatsuden, clean energy jidosha, sekitan ekika gas ka oyobi odanteki theme)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    The paper collected and arranged data on new energy technology. As to the waste power generation, in terms of general waste, 161 places have power generation facilities, 657,000 kW in output, as of the end of FY 1996. Out of them, 100 facilities (scale of output: 555,000 kW) are selling power. In terms of industrial waste, 53 places (209,000 kW) have power generation facilities. The output will be 2 million kW in FY 2000. In relation to the solar energy utilization, the number of solar systems introduced in FY 1996 is 25,000, that of water heating appliances produced in FY 1996 is 170,000. Geothermal power of 494,000 kW and 37,000 kW was introduced for electric power industry use and private use, respectively. Clean energy vehicles have not been so much spread, but the hybrid car was put on sale in 1997. Concerning the coal liquefaction, the R and D were made at a pilot plant of NEDOL process, and operation started in 1997. As to the coal gasification, investigational study and element study on the demonstration plant are being conducted in FY 1997 and 1998, making use of the research results obtained from the existing pilot plant of coal gasification combined power generation

  20. Research report for fiscal 1998. Basic research for promoting joint implementation, etc. (fuel change plan for No. 1 and No. 9 Irkutsk Heat and Power Co-Generation Plants, Irkutsk, Russia); 1998 nendo chosa hokokusho. Roshia renpo Irkuktsk shu dai 1 go oyobi dai 9 go Irkutsk netsu heikyu hatsudensho nenryo tenkan keikaku

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    A research is conducted to find out if efficiency will increase and greenhouse gas will decrease when fuel is changed from coal to gas at the above-named plants, and the economics of the plan is reviewed. The No. 1 plant comprises 18 coal-fired boilers with a total design capacity of 2985 tons/hour, and 8 steam turbine generators rated at 185MW, constructed in the 1940s. The No. 9 plant was constructed in the 1960s and 1970s. Four different modifications programs are drafted to study the fuel change plan. As the result, it is found that the addition of natural gas burning facilities to the existing heat and power co-generation plants and the modification of the existing boiler-related facilities will be low in earning rate and reliability, though excellent in budget size and cost efficiency; and that to dismantle the existing plants and to newly construct heat and power plants operating on gas turbines will bring about a higher earning rate, fuel cost reduction effect, and reliability, though such will cost more. (NEDO)

  1. Download this PDF file

    African Journals Online (AJOL)

    The Effect of Language on Human-Computer Interactions in Cameroon. ONIBEREE. A.', NGOLAHC.E.º, SHU W.S.*. Department of Computer Science, University of Buea, Cameroon ..... Multiple-choice questions asked the respondent for their.

  2. Genetics Home Reference: hypomagnesemia with secondary hypocalcemia

    Science.gov (United States)

    ... Pelken L, Lotan D, Syrrou M, Prebble JJ, Cole DE, Metzger DL, Rahman S, Tajima T, Shu SG, ... medicine? What is newborn screening? New Pages Lyme disease Fibromyalgia White-Sutton syndrome All New & Updated Pages ...

  3. Great progress in the domesticated silkworm (Bombyx mori L.)

    African Journals Online (AJOL)

    akpobome

    2013-03-13

    Mar 13, 2013 ... silk materials. This review also presents the control technology of fine filament size and the regulatory ..... size and fine structure characteristics of the cocoon filament, and the .... Li YN, Shu HG, Men W, Zhang ZF (2009).

  4. Depression among Congestive Heart Failure Patients: Results of a Survey from Central China

    Directory of Open Access Journals (Sweden)

    JPMS

    2011-10-01

    Full Text Available Tabish Hussain, Li Yu Shu, Xiang Cheng, Tumenjavkhlan Sosorburam, A.Seid Adji, Sara Tajammul, Aamra Sartaj (Union Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China (pages 38-42

  5. Army Reserve Component Personal Empowerment Program #2t

    Science.gov (United States)

    2013-10-01

    rescheduling of appointments • Retrieved lab reports from hospital lab for 161 participants 8 • Identified abnormal values and sent copies to campus nurse ...recommendation of SHU Scientific Committee • Collaborated with SHU nurse to establish procedure for abnormal lab values • Implemented suggested...results were encouraged to discuss further with nurse as per protocol. • Researched literature concerning vitamin D to better understand lab results

  6. Fiscal 1999 research and development of technologies for practical application of photovoltaic power generation systems. Research and development of photovoltaic power generation system evaluation technology (Research and development of system evaluation technology - Separate volume: Collection of data of photovoltaic power generation systems); 1999 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu. Taiyoko hatsuden system hyoka gijutsu no kenkyu kaihatsu (system hyoka gijutsu no kenkyu kaihatsu - Bessatsu: taiyoko hatsuden system data shu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    For the establishment of technologies for optimum designs and optimum operation for various types of photovoltaic power systems, data are compiled in this volume, collected from the field test facilities and residential photovoltaic power systems. Operating data and meteorological data from the field test facilities (interconnection system, independent system, and water pump system) are arranged as easy-to-use supplementary data to help studies in relation to the 'energy flow in the test field facility systems' which is in the fiscal 1999 achievement report. As for data collected from residential photovoltaic power systems, they are arranged as easy-to-use supplementary data to help studies in relation to the 'Data and evaluation of residential photovoltaic power systems' which again belongs in the fiscal 1999 achievement report. (NEDO)

  7. Vapor-liquid equilibrium data for five binary systems of methanol, tert-butylalcohol, tert-butylmethylether and water, and quaternary reactive system producing tert-butylmethylether from methanol and tert-butylalcohol; Metanoru, tert-buchiruarukoru, tert-buchirumechirueteru oyobi mizu wo kumiawaseta 5shu no niseibunkei to metanoru to tert-buchiruarukoru ni yoru eteruka hannokei no taikiatsuka ni okeru kieki heiko deta

    Energy Technology Data Exchange (ETDEWEB)

    Komatsu, H.; Nakamura, M.; Yamashita, Y.; Hirai, C. [Toyohashi Univ. of Technology (Japan)

    1997-11-01

    At atmospheric pressure, vapor-liquid equilibrium relationships for five binary systems of methanol-tert-butylalcohol, methanol-tert-butylmethylether, tert-butylalcohol-tert-butylmethylether, water-tert-butylalcohol and water-tert-butylmethylether are observed. The Wilson parameters for the binary systems have been obtained. Comparisons between the Wilson method, The ASOG method and the UNIFAC method are made. Vapor-liquid equilibrium relationships of the quaternary reactive system producing tert-butylmethylether by use of methanol and tert-butylalcohol are also observed, and it is confirmed that the Wilson parameters resulting from the data of binary systems can be used to estimate the vapor-liquid equilibrium data for the quaternary reactive system of methanol-tert-butylalcohol-tert-butylmethylether-water. 6 refs., 7 figs., 5 tabs.

  8. FY 2000 report on the results of the development of technology for commercialization of the photovoltaic power system - R and D of evaluation technology of the photovoltaic power system. Separate volume. R and D of the system evaluation technology (Data book on the photovoltaic power system); 2000 nendo New sunshine keikaku seika hokokusho. Taiyoko hatsuden system jitsuyoka gijutsu kaihatsu - Taiyoko hatsuden system hyoka gijutsu no kenkyu kaihatsu - System hyoka gijutsu no kenkyu kaihatsu (Bessatsu : Taiyoko hatsuden system data shu)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    For the purpose of establishing the optimum design and optimum operation technology of various kinds of photovoltaic power system, data were collected to make a data book on various kinds of photovoltaic power system of which the future commercialization is expected. Included in this data book were the monthly report on operation data on demonstrative test facilities at the Hamamatsu site of JQA (Japan Quality Assurance Organization), daily graph of insolation/temperature, monthly graph of wind direction/wind velocity. Further, as the data on the residential use photovoltaic power system, data on the following were summed up: information on the site of installation of the residential use photovoltaic power system (photo information, the state of installation such as sites installed more in FY 2000, drawings of module arrangement and measuring point layout, etc.), daily report on operation (graph of daily trends, daily report by site, hourly report by site, daily report on all sites, hourly report on all sites), operation data and performance indices, list of troubles arising in the residential use photovoltaic power system, other system information about residential use measuring data, power generation characteristics and {alpha}{sub pmax} of residential use solar cell modules, etc. (NEDO)

  9. FY 1998 report on the results of the New Sunshine Project - Development of the commercialization technology of the photovoltaic power system. Verification study of the photovoltaic power system - Research on engineering methods for cost effective PV installation (Data book. Survey of examples of PV systems in the world); 1998 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu seika hokokusho. Taiyoko hatsuden system no jissho kenkyu (tashu secchi koho no kenkyu kaihatsu (bessatsu data shu sekai no taiyoko hatsuden system jirei chosa))

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    For the purpose of promoting installations of PV system and making use of the unused space for which a rise in the PV demand equal to that in houses, building roofs, etc. is expected, examination/research for much newer forms of land installation are proceeded with, and evaluation/verification of reliability/durability are conducted of new installation processes using thin film solar cells, adhesives, etc. In this fiscal year, for the purpose of contributing to the study to be widely made on various installation processes, the actual survey was conducted of various applications of the system which are being planned and introduced in Japan and abroad. Emphasis was placed on making new forms of installation applicable to Japan clear. Concretely, in addition to the study of new examples, the following were conducted: renewal of existing details of the survey, and electronic filing of system block charts/pictures as a key to the information supply by electronic media such as CD-ROM. Also conducted was a study for translating the contents into English or writing them both in Japanese and English. Further, the database was made newer using these results of the most up-to-date survey, and at the same time, the results were indicated of the statistical analysis of the usage, system form, power generation scale and element equipment of various systems. (NEDO)

  10. Report on the FY 1999 survey for making a data book related to new energy technology development. Trends of solar energy utilization, waste power generation, clean energy vehicle, geothermal power generation, clean coal technology, other new energy technology and new energy technology development; 1999 nendo shin energy gijutsu kaihatsu kankei data shu sakusei chosa hokokusho. Taiyonetsu riyo, haikibutsu hatsuden, clean energy jidosha, chinetsu hatsuden, clean coal technology, sonota no shin energy gijutsu, shin energy gijutsu kaihatsu kanren doko

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    The paper collected/arranged the most up-to-date data made public in the new energy technology field. As to the solar energy utilization, the utilization is on the decrease with the beginning of the 1980s as a peak, and the solar systems introduced in FY 1998 totaled 15,000 and the water heaters 56,000. The waste power generation is showing a steady growth both in the general use and in the industrial use, and the introduction of 5 million KW is expected for FY 2010. The sale of the hybrid car started at the end of 1997, and the subjects are the price/performance/fuel supply system. Concerning the geothermal power generation, 497,000 KW and 36,000 KW were introduced for business use and non-utility use, respectively. Japan ranks sixth among nations of the world. Relating to the coal liquefaction, the pilot plant (PP) of Japan's original bituminous coal liquefaction NEDOL process finished operation in 1998, and the construction of technology package, international cooperation, etc. are being conducted. About the coal gasification, the construction of demonstrative equipment and operation are planned during FY 2002 - FY 2007, making use of the PP achievements of IGCC. In regard to the biomass-based waste power generation, the lignocellulose system is large in potential quantity. As to the hydrogen energy, the WE-NET project entered Period II. With respect to the ocean thermal energy conversion, the demonstrative study started. In relation to the wave power generation, a small size of approximately several hundred W was commercialized. (NEDO)

  11. Fiscal 1998 New Sunshine Program achievement report. Development for practical application of photovoltaic system - Research and development of photovoltaic system evaluation technology (Research and development of system evaluation technology - Photovoltaic system data book, separate volume); 1998 nendo taiyoko hatsuden system jitsuyoka gijutsu kaihatsu seika hokokusho. Taiyoko hatsuden system hyoka gijutsu no kenkyu kaihatsu (system hyoka gijutsu no kenkyu kaihatsu bessatsu (taiyoko hatsuden system data shu))

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    In the research and development of photovoltaic power generation system evaluation technology, great progress has been achieved in performance improvement and cost reduction as far as constituent devices such as power modules and inverters are concerned. In the designing of systems, however, quantitative elucidation of loss and power reduction factors remains insufficient. Under the circumstances, several types of photovoltaic power generation systems expected to be put to practical application in the future are taken up, test facilities are constructed which simulate them, and data are collected. The thus-collected data are utilized for research and development of evaluation techniques necessary for the improvement of photovoltaic system efficiency, such as design parameter quantification, databasing and utilization thereof, and simulation technologies, for the establishment of technologies for optimum designs and optimum operations. The data book accommodates data, arranged in an easy-to-use fashion, collected about verification test facility (interconnected systems, independent systems, and water pump systems) operation, weather conditions, and residential photovoltaic power generation systems. (NEDO)

  12. FY 1998 survey report. Survey to prepare a data book related to new energy technology development (Trends on the waste power generation, solar heat utilization, geothermal power generation, clean energy cars, coal liquefaction/coal gasification and new energy); 1998 nendo chosa hokokusho. Shin energy gijutsu kaihatsu kankei data shu sakusei chosa (haikibutsu hatsuden, taiyonetsu riyo, chinetsu hatsuden, clean energy, jidosha, sekitan ekika gas ka oyobi shin energy kanren doko)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    Together with the progress of technology development, policies for the introduction/promotion of new energy technology are being developed such as promotion of the commercialization development, revision of the law system, and expansion of the subsidy system for promotion. To push the introduction/promotion forward more effectively, it is necessary to arrange various kinds of data comprehensively/systematically and to make them the basic data for contribution to the spread/education. As to the six fields of the waste power generation, solar heat utilization, geothermal power generation, clean energy cars, coal liquefaction, and coal gasification of the technology fields of new energy, this report collected/arranged the data made public recently in terms mainly of the following: trends of the introduction in Japan and abroad, policy/law/subsidy system in Japan and abroad, cost, system outline, basic terms, a list of the main affiliated companies and groups, and the nation's outlook for energy introduction and policies of each new energy technology in Japan and abroad, and the trends. Moreover, characteristics by field were described of the state of the commercialization/introduction of new energy technology. (NEDO)

  13. An update for atypical haemolytic uraemic syndrome: diagnosis and treatment. A consensus document

    OpenAIRE

    Campistol, Josep M.; Arias, Manuel; Ariceta, Gema; Blasco, Miquel; Espinosa, Marío; Grinyó, Josep María; Praga, Manuel; Torrá, Roser; Vilalta, Ramón; Rodríguez de Córdoba, Santiago

    2013-01-01

    [ES]El síndrome hemolítico urémico (SHU) es una entidad clínica definida por la tríada anemia hemolítica no inmune, trombocitopenia e insuficiencia renal aguda, en la que las lesiones subyacentes están mediadas por un proceso de microangiopatía trombótica (MAT) sistémica. El SHU atípico (SHUa) es un subtipo de SHU en el que los fenómenos de MAT son consecuencia de la pérdida de regulación de la vía alternativa del complemento sobre las superficies celulares de causa genética. El SHUa es una e...

  14. An update for atypical haemolytic uraemic syndrome: diagnosis and treatment: A consensus document

    OpenAIRE

    Campistol, Josep M.; Arias, Manuel; Ariceta, Gema; Blasco, Miguel; Espinosa, Mario; Grinyó, Josep M.; Praga, Manuel; Torra, Roser; Vilalta, Ramón; Rodríguez de Córdoba, Santiago

    2013-01-01

    El síndrome hemolítico urémico (SHU) es una entidad clínica definida por la tríada anemia hemolítica no inmune, trombocitopenia e insuficiencia renal aguda, en la que las lesiones subyacentes están mediadas por un proceso de microangiopatía trombótica (MAT) sistémica. El SHU atípico (SHUa) es un subtipo de SHU en el que los fenómenos de MAT son consecuencia de la pérdida de regulación de la vía alternativa del complemento sobre las superficies celulares de causa genética. El SHUa es una enfer...

  15. DOUBLE TRIALS METHOD FOR NONLINEAR PROBLEMS ARISING IN HEAT TRANSFER

    Directory of Open Access Journals (Sweden)

    Chun-Hui He

    2011-01-01

    Full Text Available According to an ancient Chinese algorithm, the Ying Buzu Shu, in about second century BC, known as the rule of double false position in West after 1202 AD, two trial roots are assumed to solve algebraic equations. The solution procedure can be extended to solve nonlinear differential equations by constructing an approximate solution with an unknown parameter, and the unknown parameter can be easily determined using the Ying Buzu Shu. An example in heat transfer is given to elucidate the solution procedure.

  16. References

    OpenAIRE

    2018-01-01

    Aldridge, H., Kenway, P. and Born, T. (2015), ‘What Happened to Poverty Under the Coalition’. New Policy Institute. Armour, R. (2014) ‘Charity Shops Buck Trend’, http://thirdforcenews.org.uk,24 March 2014. Beatty, C. and Fothergill, S. (2016), The Uneven Impact of Welfare Reform. The Financial Losses to Places and People, Centre for Regional and Social Economic Research and Sheffield Hallam University, https://www4.shu.ac.uk/research/cresr/sites/shu.ac.uk/files/welfare-reform-2016_1.pdf Belfi...

  17. Evaluating "Cat Country": The Humor within Satire

    Science.gov (United States)

    Chang, Chung-chien Karen

    2010-01-01

    Satire, as a mode, is not frequently employed in Chinese narratives. "Cat Country," or "Mao Cheng Ji," written by Lao She (pen name of Shu Qing Chun, 1898--1966) has come under much attack of its literary values. Whereas most critics have no doubt that this work sets out to satirize China through the portrayal of a society of…

  18. Quantitative properties of the Schwarzschild metric

    Czech Academy of Sciences Publication Activity Database

    Křížek, Michal; Křížek, Filip

    2018-01-01

    Roč. 2018, č. 1 (2018), s. 1-10 Institutional support: RVO:67985840 Keywords : exterior and interior Schwarzschild metric * proper radius * coordinate radius Subject RIV: BA - General Mathematics OBOR OECD: Applied mathematics http://astro.shu-bg.net/pasb/index_files/Papers/2018/SCHWARZ8.pdf

  19. VeriML: A Dependently-Typed, User-Extensible and Language-Centric Approach to Proof Assistants

    Science.gov (United States)

    2013-01-01

    newly-arrived members of the FLINT group, especially Xinyu Feng, Alex Vaynberg, Rodrigo Ferreira, David Costanzo, Shu-Chun Weng, Jan Hoffmann and Mike...Constable, S.F. Allen, H.M. Bromley, W.R. Cleaveland, J.F. Cremer , R.W. Harper, D.J. Howe, T.B. Knoblock, N.P. Mendler, P. Panangaden, et al. Implementing

  20. Short Report Assessing the feasibility of mobile phones for follow ...

    African Journals Online (AJOL)

    largely paper-based. As part of a feasibility study ... Committee in Malawi and by the University of Washington,. USA. Victoria Hardy1, Jenny Hsieh2, Baxter Chirambo3, Tsung-Shu Joseph Wu2, John O'Donoghue4,. Adamson S. Muula5 ...

  1. Fulltext PDF

    Indian Academy of Sciences (India)

    YIMING LU1,3, PING HE2,∗, SHU-HUA MA3, GUO-ZHI LI4 and. SALEH MOBAYBEN1. 1Laboratory of Train Network, Department of Train Control Tech., Research Center of Product. & Tech., CRRC TANGSHAN CO., LTD, No. 3, Changqian Rd, Fengrun DIST, Tangshan,. Hebei, 063035, People's Republic of China. 2School ...

  2. SHORT COMMUNICATION DETERMINATION OF CYPERMETHRIN ...

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    Preferred Customer

    Spectra-physics SP8810 HPLC, equipped with UV detector; N-1NW revolving evaporator (Tokyo Physics and Chemistry Company, Japan); high-speed homogenizer (German. IKA Company); HY-4 timing multi-oscillator (JiangSu JinSheng Apparatus Factory); T500 electronic balance (ChangShu Testing Apparatus Factory); ...

  3. ACKNOWLEDGEMENTS

    Indian Academy of Sciences (India)

    Khayat Saied. Hsu Shu-Lu. Huang Chenn-Jung. Huang Baoshan. Hussain R. Jahir. Ibrahim A ... Lin Tao. Liu W.K.. Liu Jiming. Liu J. Lohani Bharat. Lucey Anthony. M Venkataramana. Madhu Kumar S D. Madria Sanjay. Mahadevappa Manjunatha.

  4. African Journal of Biotechnology - Vol 11, No 41 (2012)

    African Journals Online (AJOL)

    Lenaldo Muniz de Oliveira, Nayra da Silva Negreiros Cardoso, Luzimar Gonzaga .... Ju-Hong Zhang, Jian-Ying Guo, Jing-Yuan Xia, Fang-Hao Wan, 9873-9880 ... Zhu Xiao-yan, Chang Shu-juan, Zhang Ying-jun, Luo Hai-ling, 9894-9905.

  5. Publisher Correction: Embryonic defects induced by maternal obesity in mice derive from Stella insufficiency in oocytes.

    Science.gov (United States)

    Han, Longsen; Ren, Chao; Li, Ling; Li, Xiaoyan; Ge, Juan; Wang, Haichao; Miao, Yi-Liang; Guo, Xuejiang; Moley, Kelle H; Shu, Wenjie; Wang, Qiang

    2018-05-01

    In the version of this article originally published, the positions of Wenjie Shu and Qiang Wang in the author list were reversed and incorrect images were displayed in the HTML for Supplementary Figs. 1-12. The errors have been corrected in the HTML and PDF versions of the article.

  6. Director läks ja küsis / Indrek Randveer, Evelyn Karming, Priit Palk ... [jt.

    Index Scriptorium Estoniae

    2010-01-01

    EMT teenindus- ja müügidirektor Indrek Randveer, Estraveli müügidirektor Evelyn Karming, ABC King/Nero/SHU/Suurtüki turundusjuht Anne-Liis Ostov, kohvik-restoran Crepp juhataja Priit Palk ja Sokos Hotel Viru kommunikatsioonijuht Peep Ehasalu vastavad küsimustele, mis puudutavad nende kogemusi keerukate ja absurdsete kliendikaebuste kohta

  7. Liu et al., Afr J Tradit Complement Altern Med. (2013) 10(4):78-82 ...

    African Journals Online (AJOL)

    AJTCAM

    Tie Shu Ye is a plant in the genus Cycas in family Cycadaceae; its Latin name is Folium Cordylines Fruticosae, and it is the leaf of Cordyline fruticosa (L.) A. Cheval. .... The mechanism of morphine inhibiting gastric cancer progression in vitro might be associated with activation of caspase-9 and caspase-3 and inhibition of ...

  8. Discovery and Innovation - Vol 16, No 3 (2004)

    African Journals Online (AJOL)

    Eichhornia Crassipes) Substrate · EMAIL FULL TEXT EMAIL FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Cousins Gwanama, Keto E Mshigeni, Shu T Chang, 105-110. http://dx.doi.org/10.4314/dai.v16i3.15663 ...

  9. African Journal of Traditional, Complementary and Alternative ...

    African Journals Online (AJOL)

    Li-Long Liu, Kai Xu, Lu-Mei Kang, Shu-Ping Jiang, Qing-Hua Wang, Lei Zhang, Shao-Gui Wan, Hong-Ping Chen, 113-121 ... Cytological effects of pulsed electromagnetic fields and static magnetic fields induced by a therapeutic device on in vivo exposed rats · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT

  10. Microwave-assisted extraction and antihyperlipidemic effect of total ...

    African Journals Online (AJOL)

    Jane

    2011-05-20

    May 20, 2011 ... prevent or treat AS. MATERIALS AND METHODS. Corn silk was collected in the suburbs of Jilin city in 2010 and identified with Sweet sticky No. 1 by Wang Guang- shu from Jilin. University. Anhydrous ethanol, methanol, aluminum chloride, concentrated hydrochloric acid, petroleum ether, ethyl acetate and.

  11. Browse Title Index

    African Journals Online (AJOL)

    Items 101 - 150 of 427 ... Vol 21, No 1-2 (2009), Analysis and Construction of the Macro-monitoring Indicators Based on the Currency Crisis, Abstract. Y Yin, F Shu-qiong ... Vol 15, No 3 (2003), Biochemical and microbiological changes in Plantain (Musa paradisiacal) at various stages of ripening, Abstract. BO Agoreyo, IF ...

  12. non absorbable sutures in the urinary bladder resulting

    African Journals Online (AJOL)

    The vesical calculus. Urol Clin North AM. 2000, 27:333-346. 3. Evans JW, Chapple CR, Ralph DJ, Millory EJ: Bladder calculus formation as a complication of the Stamey procedure. Br J Urol 1990,. 65:580-582. 4. Sheng-Tsun Su, He-Fu Haung, Shu-Fen. Chang. Encrusted Bladder stone on Non- absorbable sutures after a ...

  13. Browse Title Index

    African Journals Online (AJOL)

    Items 201 - 250 of 2037 ... Vol 14, No 11 (2015), Antibacterial Activity and Mode of Action of Mentha arvensis Ethanol Extract against Multidrug-Resistant Acinetobacter baumannii, Abstract PDF. Ling Zhang, Shu-gen Xu, Wei Liang, Jun Mei, Yue-ying Di, Hui-hua Lan, Yan Yang, Wei-wei Wang, Yuan-yuan Luo, Hou-zhao Wang.

  14. Tropical Journal of Pharmaceutical Research - Vol 14, No 11 (2015)

    African Journals Online (AJOL)

    Antibacterial Activity and Mode of Action of Mentha arvensis Ethanol Extract against Multidrug-Resistant Acinetobacter baumannii · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Ling Zhang, Shu-gen Xu, Wei Liang, Jun Mei, Yue-ying Di, Hui-hua Lan, Yan Yang, ...

  15. Berkeley Lab - Materials Sciences Division

    Science.gov (United States)

    conjugation using genetically encoded aldehyde tags. Nature Protocols 7, 1052 (2012). abstract » J. Y. Shu, R . Onoe, R. A. Mathies and M. B. Francis. Direct Attachment of Microbial Organisms to Material Surfaces -modified proteins to their binding partners. Proceedings of the National Academy of Sciences 109, 4834

  16. 75 FR 56982 - Narrow Woven Ribbons With Woven Selvedge From Taiwan and the People's Republic of China: Amended...

    Science.gov (United States)

    2010-09-17

    ...: Margin Exporter or producer (percent) Taiwan Roung Shu Industry Corporation 4.37 All Others 4.37 Margin... Ribbons With Woven Selvedge From Taiwan and the People's Republic of China: Amended Antidumping Duty...: Notice of amended antidumping duty orders. FOR FURTHER INFORMATION CONTACT: Holly Phelps (Taiwan), AD/CVD...

  17. Calycosin regulates glucocorticoid-induced apoptosis via Nrf2/ARE ...

    African Journals Online (AJOL)

    Lifeng Fu1, WeiLiang Wu2, Jian Zhu2, Shu Qiang2, Jansong Chen2* ... Results: CA reduced the apoptosis and accumulation of ROS in DEX-treated cells. ..... its downstream effectors (Figure 5 A-C). However .... Cao J, Chen Z, Zhu Y, Li Y, Guo C, Gao K, Chen L, Shi ... Hong W. Experimental study on the effect of Calycosin.

  18. Journal of Genetics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics; Volume 90; Online resources. Genotyping of the k-casein and -lactoglobulin genes in Chinese Holstein, Jersey and water buffalo by PCR-RFLP. Da-Xi Ren Shu-Ying Miao You-Liang Chen Cai-Xia Zou Xian-Wei Liang Jian-Xin Liu. Volume 90 Online resources 2011 pp e1-e5 ...

  19. The Vicissitudes of a Medieval Japanese Warrior

    DEFF Research Database (Denmark)

    Oxenbøll, Morten

    2007-01-01

    In standard accounts of medieval Japanese society, enormous stress is put on the conflicts between local landholders (zaichi ryôshu) and absentee proprietors. Fuelled by the debate on feudalism that divided scholars up until the early 1990s, these conflicts have widely been recognised as proof...

  20. INSA - AASAA joint workshop | Women in Science | Initiatives ...

    Indian Academy of Sciences (India)

    Presentations at the INSA-AASAA joint workshop on "Women in Science, Education and Research" ... Mon-Shu Ho, National ChungHsing University, Nepal ... Charusita Chakravarty, one of the stars of our community of women scientists, at a ...

  1. The First Known Chinese Woman Historian

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    <正> Ban Zhao, the first known Chinese woman historian, lived during the Eastern Han Dynasty( 25-220 A.D.), and is renowned for her contribution to the completion of Han Shu( History of the Han Dynasty), which covers the entire Western Han period( 206B.C.-24A.D.). As China’s first book on dynastic history, it constitutes the second volume in Twenty-Four Histories, and sets the style of writing for the rest of the dynastic annals. Han Shu consists of 120 volumes divided in to four parts: Biographies of the 12 Western Han emperors and major events during the reign of each emperor, the "Eight Tables," chronologically listing the names of princes, the emperor’s in laws and the leading officials; the "The Registries," dealing with rules and laws and Biographies of 70 outstanding personalities. Of the four parts, the "Eight Tables" was compiled by Ban Zhao.

  2. Una registrazione neo-sumerica di orzo da Nippur

    Directory of Open Access Journals (Sweden)

    di Pasquale, Emanuella

    2003-06-01

    Full Text Available This article presents the edition of a Neo-Sumerian cuneiform text from Nippur. The tablet records a balanced account of barley distributed to several people under the supervision of Lu-Enlila, and is dated to the sixth month of Shu-Suen's fifth year

    El artículo presenta la edición de un texto cuneiforme de época neo-sumeria procedente de la ciudad de Nippur. La tablilla registra un balance contable de asignaciones de cebada a diversos individuos, bajo la responsabilidad de Lu-Enlila. El documento está datado en el sexto mes del año 5 de reinado de Shu-Suen.

  3. A Tale of Two Utopias: Kang Youwei’s Communism, Mao Zedong’s Classicism and the “Accommodating Look” of the Marxist Li Zehou

    Directory of Open Access Journals (Sweden)

    Federico BRUSADELLI

    2017-01-01

    Full Text Available In the Datong Shu the Confucianist philosopher Kang Youwei (1858–1927 attempted to describe in an utopian fashion the end of history, as consisting of the abolition of private property, the institution of a world government, the disruption of marriage and the eradication of social differences. With his book, Kang somehow anticipated Mao’s use of the traditional ideal of datong as a revolutionary concept. In my paper, I will discuss a debate on the Datong Shu from the 1950’s, when a young Li Zehou (1930– defended Kang’s utopianism from the accusations of ‘conservatism’ moved by orthodox Marxists. Li’s “benevolent look” on Kang may serve as an interesting anticipation of his later efforts to synthesize Marxist and Confucianism.

  4. Assessment of IRI-2016 profile parameters over Indian low latitude station

    Science.gov (United States)

    Patel, Nilesh C.; Karia, Sheetal P.; Pathak, Kamlesh N.

    2018-05-01

    The present study reports the assessment of the bottom-side profile thickness (B0), shape (B1) and F2-peak height (hmF2) parameters IRI-2016 model over the Indian region by using digisonde observations. The digisonde data from a low latitude station Ahmedabad, (located at the crest of the northern equatorial anomaly) during three months June-2012, July-2012 and December-2012 are considered for this study. Simultaneous comparison is made on the performance of three different options `Gul-1987', `Bil-2000' and the `ABT-2009' for the bottom-side profile, three different options`AMTB2013 (AMT)', `SHU-2015 (SHU)', and `BSE-1979 (BSE)' for the hmF2 estimation in the latest available IRI-2016 to that obtained from digisonde measurements. Further, the diurnal characteristics of the B0 and B1 from digisonde measurements are also compared with those from the IRI-2016 model using the three different options.

  5. Use acupuncture to treat functional constipation: study protocol for a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Li Ying

    2012-07-01

    Full Text Available Abstract Background Whether acupuncture is effective for patients with functional constipation is still unclear. Therefore, we report the protocol of a randomized controlled trial of using acupuncture to treat functional constipation. Design A randomized, controlled, four-arm design, large-scale trial is currently undergoing in China. Seven hundred participants are randomly assigned to three acupuncture treatment groups and Mosapride Citrate control group in a 1:1:1:1 ratio. Participants in acupuncture groups receive 16 sessions of acupuncture treatment, and are followed up for a period of 9 weeks after randomization. The acupuncture groups are: (1 Back-Shu and Front-Mu acupoints of Large Intestine meridians (Shu-Mu points group; (2 He-Sea and Lower He-Sea acupoints of Large Intestine meridians (He points group; (3 Combining used Back-Shu, Front-Mu, He-Sea, and Lower He-Sea acupoints of Large Intestine meridians (Shu-Mu-He points group. The control group is Mosapride Citrate group. The primary outcome is frequency of defecation per week at the fourth week after randomization. The secondary outcomes include Bristol stool scale, the extent of difficulty during defecating, MOS 36-item Short Form health survey (SF-36, Self-Rating Anxiety Scale (SAS, and Self-rating Depression Scale (SDS. The first two of second outcomes are measured 1 week before randomization and 2, 4, and 8 weeks after randomization. Other second outcomes are measured 1 week before randomization and 2 and 4 weeks after randomization, but SF-36 is measured at randomization and 4 weeks after randomization. Discussion The result of this trial (which will be available in 2012 will confirm whether acupuncture is effective to treat functional constipation and whether traditional acupuncture theories play an important role in it. Trials registration Clinical Trials.gov NCT01411501

  6. Browse Title Index

    African Journals Online (AJOL)

    Items 51 - 100 of 1309 ... Li-Long Liu, Kai Xu, Lu-Mei Kang, Shu-Ping Jiang, Qing-Hua Wang, ... CR Sewani-Rusike, JE Iputo, EJ Ndebia, M Gondwe, DR Kamadyaapa ... K-M Man, W-C Chen, H-M Wang, H-Y Chen, J-L Shen, L-D Chen, F-J Tsai, ...

  7. Bulletin of Materials Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science; Volume 36; Issue 4. Investigation of localization effect in GaN-rich InGaN alloys and modified band-tail model. Chuan-Zhen Zhao Bin Liu De-Yi Fu Hui Chen Ming Li Xiang-Qian Xiu Zi-Li Xie Shu-Lin Gu You-Dou Zheng. Volume 36 Issue 4 August 2013 pp 619-622 ...

  8. JPRS Report. Science & Technology: Japan.

    Science.gov (United States)

    1988-12-09

    Molding Technology [Takashi Kasai , Akihiko Hirota; KIKAI TO KOGU, May 88] 106 Injection Molding Technology [Toshiyuki Iwahashi; KIKAI TO KOGU, May 88...Development Shu Isa -Planning Office Fumio Sato —Control Office Shizuka Kudo - Patent Office Taro Inoue —Technical Information Office Takeshi...the possibility that a more serious situation could occur. Fumio Kaneko, who is in charge of the marine sector, joined the company in 1971 after

  9. [Study on corresponding areas the liver and lung channels in brain with fMRI].

    Science.gov (United States)

    Xu, Fang-Ming; Xie, Peng; Lü, Fa-Jin; Mou, Jun; Li, Yong-Mei; Zhao, Jian-Nong; Chen, Wei-Juan; Gong, Qi-Yong; Zhao, Li-Bo; Liu, Qing-Jun; Shen, Lin; Zhai, Hong; Yang, De-Yu

    2007-10-01

    To explore distribution of the Liver and Lung Channels in the brain so as to provide imaging basis for construction of channel theory in the brain. Sixty healthy student volunteers were randomly divided into a Liver Channel group (I) and a Lung Channel group (II), and the each group was further divided into five subgroups with 6 volunteers in each subgroup, based on five-shu-point principles which, were Dadun (LR 1, I 1), Xingjian (LR 2, I 2), Taichong (LR 3, I 3), Zhongfeng (LR 4, I 4), Ququan (LR 8, I 5), Shaoshang (LU 11, II 1), Yuji (LU 10, II 2), Taiyuan (LU 9, II 3), Jingqu (LU 8, II 4), and Chize (LU 5, II 5), respectively. In order to observe the brain activating patterns during acupuncture at the different acupoints, functional magnetic resonance imaging (fMRI) technique was adopted. All image data were then analyzed with SPM 2 software. The statistical parameter gram was composed of the pixel P areas, and the commonly activated area of five-shu-point of each channel was considered as the brain distribution of the Liver and Lung Channels. The common areas activated by the five-shu-points of the Liver Channel were homolateral Brodmann area (BA) 34, BA 47, red nucleus, contralateral BA 19, BA 30, BA 39, the superior parietal lobule, cerebellum decline, and bilateral BA 3 and culmen. The common areas activated by the five-shu-points of the Lung Channels included homolateral BA 2, BA 18, BA 35, and contralateral BA 9 and substania nigra. There are relatively specific corresponding brain areas for the Liver and Lung Channels, indicating that there is possible relatively specific connection between channels and the brain.

  10. AN INVESTIGATION OF THE RELATIONSHIP BETWEEN PRODUCT HAPTIC ACCESSIBILITY AND CONSUMER RESPONSE: A BRAND PERSPECTIVE

    OpenAIRE

    Karangi, Sheena Wanjiku

    2017-01-01

    Consumers generally like touching products before buying and prior research indicates that touching influences the purchase decision-making process (e.g. McCabe & Nowlis, 2003; Peck & Childers, 2003a; Peck & Johnson, 2011; Peck & Shu, 2009; Webb & Peck, 2015). For example, touching products has a positive effect on consumer attitudes, intentions and behaviours and these effects seem to vary by product category, situational context and need for touch. Touch research however has principally rec...

  11. Beneficial and Deleterious Bacterial - Host Interactions in Chronic Wound Pathophysiology

    Science.gov (United States)

    2015-04-02

    treatment with P. acnes that had been incubated in PBS.70 This study suggests that glycerol fermentation and the production of compounds, like...SE, Wolcott RD, Zischkau AM. Identification of yeast in chronic wounds using new pathogen-detection technologies. J Wound Care. 2009;18(3):103–104...University. 2008;11(3):111–116. 70. Shu M, Wang Y, Yu J, et al. Fermentation of Propionibacterium acnes, a commensal bacterium in the human skin

  12. Testing and Validation of High Density Resequencing Microarray for Broad Range Biothreat Agents Detection

    Science.gov (United States)

    2009-08-11

    concentration of the virus was expressed in plaque forming units (pfu). For synthetic DNA templates, the DNA concentration was used to calculate the...cells ATCC Escherichia coli O157:H7 ATCC 43985 (CDC EDL933) Nucleic acid ATCC Francisella tularensis SHU4 Nucleic acid AFIP Leptospira interrogans ATCC...2% on the nucleotide level and 0.6% on the protein level. Similar strain discrimination was obtained in case of Machupo virus strains Carvallo and

  13. Combat Veterans with Comorbid PTSD and Mild TBI Exhibit a Greater Inhibitory Processing ERP from the Dorsal Anterior Cingulate Cortex

    Science.gov (United States)

    2014-08-08

    emotion processing biases in depressed undergraduates. Biological Psychology 81, 153–163. Krompinger, J.W., Simons, R.F., 2011. Cognitive inefficiency...in depressive under- graduates: stroop processing and ERPs. Biological Psychology 86, 239–246. Lanius, R.A., Vermetten, E., Loewenstein, R.J., Brand...prefrontal cortex and anterior cingulate during error processing. Psychosomatic Medicine 74, 471–475. I.-W. Shu et al. / Psychiatry Research: Neuroimaging 224

  14. Marijuana and the U.S. Navy: The Impact of Changing Laws, Attitudes and Behavior on Recruiting

    Science.gov (United States)

    2017-03-01

    Shu Chen Academic Associate Graduate School of Business and Public Policy iv THIS PAGE INTENTIONALLY LEFT BLANK v ABSTRACT While marijuana... Business Insider, in FY13, California had the largest recruiting numbers for the military in comparison with the rest of the nation; California...the public opinion on marijuana. It found that “ millennials —those ages 18 to 35 in 2016—are more than twice as likely to support legalization of

  15. Chemical analysis of simulated high level waste glasses to support stage III sulfate solubility modeling

    Energy Technology Data Exchange (ETDEWEB)

    Fox, K. M. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2016-03-17

    The U.S. Department of Energy (DOE), Office of Environmental Management (EM) is sponsoring an international, collaborative project to develop a fundamental model for sulfate solubility in nuclear waste glass. The solubility of sulfate has a significant impact on the achievable waste loading for nuclear waste forms within the DOE complex. These wastes can contain relatively high concentrations of sulfate, which has low solubility in borosilicate glass. This is a significant issue for low-activity waste (LAW) glass and is projected to have a major impact on the Hanford Tank Waste Treatment and Immobilization Plant (WTP). Sulfate solubility has also been a limiting factor for recent high level waste (HLW) sludge processed at the Savannah River Site (SRS) Defense Waste Processing Facility (DWPF). The low solubility of sulfate in glass, along with melter and off-gas corrosion constraints, dictate that the waste be blended with lower sulfate concentration waste sources or washed to remove sulfate prior to vitrification. The development of enhanced borosilicate glass compositions with improved sulfate solubility will allow for higher waste loadings and accelerate mission completion.The objective of the current scope being pursued by SHU is to mature the sulfate solubility model to the point where it can be used to guide glass composition development for DWPF and WTP, allowing for enhanced waste loadings and waste throughput at these facilities. A series of targeted glass compositions was selected to resolve data gaps in the model and is identified as Stage III. SHU fabricated these glasses and sent samples to SRNL for chemical composition analysis. SHU will use the resulting data to enhance the sulfate solubility model and resolve any deficiencies. In this report, SRNL provides chemical analyses for the Stage III, simulated HLW glasses fabricated by SHU in support of the sulfate solubility model development.

  16. [Textual research on Chen Ye and his Jia cang jing yan fang (Family-preserved Empirical Recipes) of the Song Dynasty].

    Science.gov (United States)

    Zhang, Xuedan; Zhang, Ruqing; Chen, Dexing

    2014-01-01

    Chen Ye, an official of the Southern Song Dynasty, also known as Chen Rihua as his styled name, was born in Changle, Fuzhou in the reign of Shaoxing, and died during the reign of Duanping. He had been consecutively in the positions of Jiang shi lang (Court Gentleman for Ceremonial Service), Zhi zhou (Prefect) of Lingding, the Ti xing (Judicial Commissioner) of Guangdong, the Zong ling (Overseer-general) of Sichuan, Shan ding (Reviser), Shu lin and other positions in Tongzhou, Yuanzhou. His works included 1 volume of Gu ling xian sheng nian pu (Mr. Guling's Chronological Biography), 1 volume of Tan xie (On Humor), 1 volume of Shi hua (Poetry), 8 volumes of Jin yuan li shu (Jin Yuan's Smart Technique), 3 volumes of Yi jian zhi lei bian (Classified Compilation of Yijian's Annals), (Zeng guang) Suo sui lu (Augmented Records of Trivial Matters), 5 volumes of Jia cang jing yan fang (Family-preserved Empirical Recipes). He also compiled the 8-volume Yin jiang zhi (Yinjiang's Annals), published the 2-volume Jia cang ji yao fang (Collected Essential Recipes from Family Preservation), and other proses and poetry. Jia cang jing yan fang was a formulary compiled by Chen Ye, which was lost. Altogether 74 of its recipes were cited in Fu ren da quan liang fang (Complete Effective Prescriptions for Women's Diseases), Shou qin yang lao shu (A Book for Pursuing Seniors' Longevity and Healthcare), Pu ji fang (Prescriptions for Universal Relief) and Yong le da dian (Yongle Encyclopedia).

  17. [Exploration of acupoint combination and needling techniques in the reinforcing and reducing manipulation at different acupoints].

    Science.gov (United States)

    Dai, Qing; Sheng, Xiesun; Chen, Feng

    2017-04-12

    The reinforcing and reducing manipulation at different acupoints is a kind of acupuncture manipulations and has satisfactory clinical therapeutic effects, combined with a proper needling techniques. The reinforcing needling method is used in the upper and the reducing one in the lower, the distal acupoints are combined with the nearby acupoints. The local acupoints or adjcant acupoints of the affected area are regarded as the nearby acupoints, e.g. the acupoints in the upper. The distant acupoints and the acupoints on the hand and foot are named as distal acupoints, e.g. the acupoint in the lower. In the reinforcing manipulation, the needle is inserted shallowly along the running direction of meridian. In the reducing manipulation, the needle is inserted deeply and against the running direction of meridian. The yin - yang couple needling technique is used with the combination of the front- mu and back- shu points. In the first option, the reinforcing and reducing needling method with rotating technique is predominated at the front- mu points, while that with lifting and thrusting technique is at the back- shu points. In the second option, when needling the back- shu points, the needling sensation is transmitted along the transverse segment and far to the chest and abdomen. These two kinds of integration of acupoint combination and needling techniques display a certain clinical significance in improving the therapeutic effects of acupuncture.

  18. Assessing the impact of educational intervention in patients with hypertension.

    Science.gov (United States)

    Ho, Tai Mooi; Estrada, Dolors; Agudo, Josep; Arias, Piedad; Capillas, Raúl; Gibert, Elvira; Isnard, Mª Mar; Solé, Mª José; Salvadó, Anna

    2016-12-01

    It is accepted that patient education can be beneficial in the treatment of chronic diseases. We conducted an educational intervention (EI) in hypertensive patients seen at Primary Care centres (PCC) and specialised Hypertension Units (SHU). To assess patient's knowledge of hypertension and to verify the impact of this educational initiative. A multicentre quasi-experimental study with the participation of 120 patients with hypertension. EI consisted of oral and written information which included the definition of hypertension, causes, cardiovascular risk factors and means of control. A self-administered questionnaire was used to assess patient's knowledge before and after EI. Sixty-two (52%) patients were from PCC and 58 (48%) from SHU (mean age: 61 ± 13.3 years, 59% were women). There were no differences in baseline characteristics between patients attending at PCC and SHU. The definition of hypertension (blood pressure ≥140 mmHg and/or ≥90 mmHg was known by 48% and 99% of the participants before and after EI, respectively (p hypertension was related to kidneys (54%) and eyes (58%). After EI this knowledge increased to 100% (p hypertension. However, further studies are needed to assess if EI produces behaviour changes in the long term, as this might enhance optimal blood pressure control to prevent kidney disease or delay its progression. © 2016 European Dialysis and Transplant Nurses Association/European Renal Care Association.

  19. Analysis of Business Revenue Residual Sharing System in Cooperatives in Indonesia on Islamic Law Review: A case study at KSU Mitra Bersama in Palu City

    Directory of Open Access Journals (Sweden)

    Abidin Djafar

    2018-03-01

    Full Text Available This study aims to explain profit sharing system in Mitra Bersama Cooperative in the Overview of Islamic Law. To achieve this objective, this research uses descriptive qualitative method by employing three data collecting techniques i.e. observation, interview, as well as documentation. The data of this research are obtained from the Chairman, the Secretary and the Employees of the Multipurpose Cooperative (KSU Mitra Bersama. The results showed that the distribution of Business revenue Residual (SHU, at Mitra Bersama Cooperative, amounted to 5% which was distributed to all members of the cooperative in December. This sharing system displays no injustice and extortion disadvantageous to the cooperative’s members.  It performs an open management system and shares the profits and losses to its members according to the prevailing regulations already known by all shareholders. We concluded that the system of the Business Revenue Residual (SHU sharing at this Multipurpose Cooperative is permissible in Islam. Therefore, the results of this study can be used as a good model for Business Revenue Residual (SHU sharing system which conforms to Islamic Law.

  20. 五鍼刺法원리 및 임상응용에 관한 연구 I 원리에 관한 연구

    Directory of Open Access Journals (Sweden)

    Ahn Chang-beohm

    2008-09-01

    Full Text Available Objective : To review the theoretic basis of the Sa -Ahm 5 Element acupuncture devised about 360 years ago, papers and books were researched. Methods : Total of 59 books and papers ranging from ancient Huang Di nei jing to modern Bio Medical Acupuncture for Pain Management were researched to study the basic theory of it in relation to the 5 Shu points, Results : Gao-mu in Chinese Ming dynasty, for the 1st time, had used 5 Shu points based on creation cycle as tonification and sedation treatment respectively and named it as ‘tonification and sedation treatment of self meridian’ but since then, this method, without special reasons, has been rarely used until Sa -Ahm’s new doctrine that include the concept of destruction cycle was asserted. Conclusions : Sa - Ahm 5 Element acupuncture is a method which uses 5 Shu points from the viewpoints of simultaneous tonification and sedation methods which are based on promotion and control cycles. Though it is nowadays mostly-used method in accordance with practitioner’s points, it needs to be set guidelines by which to effectively practice Sa -Ahm acupuncture.

  1. A Modern Clinical Approach of the Traditional Korean Saam Acupuncture

    Directory of Open Access Journals (Sweden)

    Manyong Park

    2015-01-01

    Full Text Available Saam acupuncture is one of the original therapeutic modalities representing traditional Korean medicine. It was originally described in a manuscript that is estimated to be published at some point between 1644 and 1742, in the middle of the Cho Sun dynasty, by a Korean Buddhist monk whose name is unknown. The principle of combining five shu points is based on the theory of Nan-jing. The treatment and diagnosis concepts in Saam acupuncture were mainly influenced by Dongeuibogam and Chimgoogyeong-heombang. The basic characteristic of combining five shu points in Saam acupuncture is the selection of the tonification and sedation points along the self-meridian and other meridians based on creation and governor relationships. Saam acupuncture clinical studies have mainly focused on musculoskeletal pain and autonomic nervous system regulation. From a neurophysiological perspective, Saam acupuncture, which involves five shu points as the main treatment aspect, has the advantage of increasing parasympathetic nerve activation and adjusting the balance of the autonomic nervous system. Inserting a needle into the skin layer while considering the respiratory phase and stimulating the needle gently and lightly could maximize the effect of Saam acupuncture. The specific Saam acupuncture prescribed should be identified on the basis of the neurobiological perspective.

  2. [Comparison of efficacy on functional constipation treated with electroacupuncture of different acupoint prescriptions: a randomized controlled pilot trial].

    Science.gov (United States)

    Wu, Jia-Ni; Zhang, Bi-Ying; Zhu, Wen-Zeng; Du, Ruo-Sang; Liu, Zhi-Shun

    2014-06-01

    To evaluate preliminarily the efficacy on functional constipation treated with electroacupuncture of different acupoint prescriptions. One hundred and four patients were randomized into a front-mu and back-shu points group (19 cases), a he-sea points group (34 cases), a he-sea, front-mu and back-shu points group (26 cases) and a western medication control group (25 cases). In the front-mu and back-shu points group, electroacupuncture was applied at bilateral Tianshu (ST 25) and Dachangshu (BL 25). In the he-sea points group, electroacupuncture was applied at bilateral Quchi (LI 11) and Shangjuxu (ST 37). In the he-sea, front-mu and back-shu points group, electroacupuncture was applied at unilateral Tianshu (ST 25), Dachangshu (BL 25), Quchi (LI 11) and Shangjuxu (ST 37). In the three groups above, the treatment was given 5 times a week in the first two weeks and 3 times a week in the next two weeks. In the western medication control group, mosapride citrate tablets were prescribed for oral administration, 1 table (5 mg) each time, 3 times a day, continuously for 4 weeks. The period of research was 9 weeks, including 1 week for baseline evaluation, 4 weeks for treatment and 4 weeks for follow-up. The weekly defecation frequency was taken as primary index, while the defecation difficulty and life quality score were taken as the secondary indices for the efficacy evaluation after treatment and in follow-up. According to the intention-to-treat (ITT) analytic principle, 104 cases were all enrolled in the final analysis. (1) After treatment, the weekly frequency of defecation was all increased significantly in the four groups (P electroacupuncture groups was similar to that of western medication control group (P > 0.05). In follow-up, the increasing effect on the weekly frequency of defecation was maintained in the he-sea points group (P 0.05). (2) After treatment, defecation difficulty was relieved in the he-sea points group, the he-sea, front-mu and back-shu points

  3. Effects of acupuncture treatment on depression insomnia: a study protocol of a multicenter randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Chen Yuan-Fang

    2013-01-01

    Full Text Available Abstract Background More than 70% of patients with depression who see their doctors experience insomnia. Insomnia treatment is a very important link for depression treatment. Furthermore, antidepression treatment is also important for depression insomnia. In acupuncture, LU-7 (Lie Que and KID-6 (Zhao Hai, which are two of the eight confluence points in meridian theory, are used as main points. An embedded needle technique is used, alternately, at two groups of points to consolidate the treatment effect. These two groups of points are BL-15 (Xin Shu with BL-23 (Shen Shu and BL-19 (Dan Shu with N-HN-54 (An Mian. The effectiveness of these optimized acupuncture formulas is well proven in the practice by our senior acupuncturists in Guangdong Provincial Hospital of TCM. This study has been designed to examine whether this set of optimized clinical formulas is able to increase the clinical efficacy of depression insomnia treatment. Methods/design In this randomized controlled multicenter trial, all the eligible participants are diagnosed with depression insomnia. All participants are randomly assigned to one of two groups in a ratio of 1:1 and receive either conventional acupuncture treatment or optimized acupuncture treatment. Patients are evaluated using the Pittsburgh Sleep Quality Index(PSQIand the Hamilton rating scale(HAMD for depression. The use of antidepression and hypnotics drugs is also considered. Results are obtained at the start of treatment, 1 and 2 months after treatment has begun, and at the end of treatment. The entire duration of the study will be approximately 36 months. Discussion A high quality of trial methodologies is utilized in the study, and the results may provide better evidence for the effectiveness of acupuncture as a treatment for depression insomnia. The optimized acupuncture formula has potential benefits in increasing the efficacy of treating depression insomnia. Trial registration The trial was registered in

  4. Stellar outflow: relative motions of nebulae and Of stars

    International Nuclear Information System (INIS)

    Lynds, B.T.

    1979-01-01

    On the basis of arguments presented by Roberts (1972) and of Shu et al. (1972), Minn and Greenberg (1973) argued that the velocity differences between newly formed hot stars and the surrounding interstellar medium are sufficiently different so that typical H II regions should consist of material which is continually being replaced by the ambient medium and which should therefore possess the velocity of the medium rather than that of the star. The critical test of this hypothesis will be a comparison of nebular velocities with the velocities of the exciting stars. This is performed for Of stars and nebulae. (Auth.)

  5. [Characteristics of acupoint application for the sub-healthy condition treated with ancient and modern acupuncture based on data mining exploration].

    Science.gov (United States)

    Cai, Liyan; Wu, Jie; Ma, Tingting; Yang, Lijie

    2015-10-01

    The acupoint selection was retrieved from the ancient and modern literature on the treatment of sub-healthy condition with acupuncture. The law of acupoint application was analyzed so as to provide a certain reference to the determination of acupoint prescription in clinical acupuncture. The ancient literature was retrieved from Chinese basic ancient literature database. The modern literature was retrieved from Cochrane Library, Medline, PubMed, Ovid evidence-based medicine database, Chinese biomedical literature database, China journal full-text database, VIP journal full-text database and Wanfang database. The database mining software was adopted to explore the law of acupoint application in treatment of sub-healthy conditions with ancient and modern acupuncture. The acupoint use frequency, compatibility association rule, law for meridian use and the use regularity of specific points were analyzed. In the ancient treatment for sub-healthy condition, the top five commonly used acupoints are Shenmen (HT 7), Zhaohai (KI 6), Taibai (SP 3), Daling (PC 7) and Taixi (KI 3). The most commonly combined points are Zhangmen (LR 13), Taibai (SP 3) and Zhaohai (KI 6). The most commonly used meridians are the bladder meridian of foot-taiyang, kidney meridian of foot-shaoyin and liver meridian of foot-jueyin. The most commonly used specific points are the five-shu points. The most commonly used acupoints are located in the lower limbs. In the modern treatment, the top five commonly used acupoints are Zusanli (ST 36), Sanyinjiao (SP 6), Baihui (GV 20), Shenshu (BL 23) and Guanyuan (CV 4). The most commonly supplemented points are Hegu (LI 4) and Taichong (LR 3). The most commonly used meridians are the bladder meridian of foot-taiyang, the conception vessel and the governor vessel. The most commonly used specific points are the back-shu points. The most commonly used acupoints are located in the lower limbs. After the systematic comprehension of the relevant ancient and modern

  6. Density-dependent habitat selection and performance by a large mobile reef fish.

    Science.gov (United States)

    Lindberg, William J; Frazer, Thomas K; Portier, Kenneth M; Vose, Frederic; Loftin, James; Murie, Debra J; Mason, Doran M; Nagy, Brian; Hart, Mary K

    2006-04-01

    Many exploited reef fish are vulnerable to overfishing because they concentrate over hard-bottom patchy habitats. How mobile reef fish use patchy habitat, and the potential consequences on demographic parameters, must be known for spatially explicit population dynamics modeling, for discriminating essential fish habitat (EFH), and for effectively planning conservation measures (e.g., marine protected areas, stock enhancement, and artificial reefs). Gag, Mycteroperca microlepis, is an ecologically and economically important warm-temperate grouper in the southeastern United States, with behavioral and life history traits conducive to large-scale field experiments. The Suwannee Regional Reef System (SRRS) was built of standard habitat units (SHUs) in 1991-1993 to manipulate and control habitat patchiness and intrinsic habitat quality, and thereby test predictions from habitat selection theory. Colonization of the SRRS by gag over the first six years showed significant interactions of SHU size, spacing, and reef age; with trajectories modeled using a quadratic function for closely spaced SHUs (25 m) and a linear model for widely spaced SHUs (225 m), with larger SHUs (16 standardized cubes) accumulating significantly more gag faster than smaller 4-cube SHUs (mean = 72.5 gag/16-cube SHU at 225-m spacing by year 6, compared to 24.2 gag/4-cube SHU for same spacing and reef age). Residency times (mean = 9.8 mo), indicative of choice and measured by ultrasonic telemetry (1995-1998), showed significant interaction of SHU size and spacing consistent with colonization trajectories. Average relative weight (W(r)) and incremental growth were greater on smaller than larger SHUs (mean W(r) = 104.2 vs. 97.7; incremental growth differed by 15%), contrary to patterns of abundance and residency. Experimental manipulation of shelter on a subset of SRRS sites (2000-2001) confirmed our hypothesis that shelter limits local densities of gag, which, in turn, regulates their growth and

  7. [Beyond suffering, schizophrenic improvisation and therapeutic challenges].

    Science.gov (United States)

    Bizot, Tatiana

    2016-01-01

    Led jointly by an actress and an occupational therapist, an 'improvisation' activity has been set up within the Sainte-Anne University Hospital SHU Sector 14 for hospitalised patients, on medical prescription. This containing environment provides psychological support and encourages patients with schizophrenia to explore their creativity and to 'let go' so as to discover new physical possibilities. The group thereby becomes a support for the relationship and the development of verbal and non-verbal communication. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  8. Simulations of axisymmetric, Newtonian star clusters - prelude to 2 + 1 general relativistic computations

    International Nuclear Information System (INIS)

    Shapiro, S.L.; Teukolsky, S.A.

    1987-01-01

    The dynamical behavior of nonspherical systems in general relativity is analyzed, allowing for rotation and the emission of gravitational waves. An axisymmetric code for solving the Vlasov equation in the Newtonian limit based on a mean-field particle simulation scheme is constructed and tested by reproducing the known evolution of homogeneous spheroids with and without rotation, including the Lin-Kestel-Shu instability. Results for the collapse of homogeneous, nonequilbrium spheroids are described, and stability studies of homogeneous, equilibrium spheroids are summarized. Finally, the code is used to follow the evolution of inhomogeneous, centrally condensed spheroids, and the results are compared with those for homogeneous collapse. 22 references

  9. High infiltration of tumor-associated macrophages in triple-negative breast cancer is associated with a higher risk of distant metastasis

    OpenAIRE

    Yuan, Zhong-Yu; Luo, Rong-Zhen; Peng, Rou-Jun; Wang, Shu-Sen; Xue, Cong

    2014-01-01

    Zhong-Yu Yuan,1–3* Rong-Zhen Luo,1,2,4,* Rou-Jun Peng,1–3 Shu-Sen Wang,1–3 Cong Xue1–3 1State Key Laboratory of Oncology in South China, 2Collaborative Innovation Center for Cancer Medicine, 3Departments of Medical Oncology, Sun Yat-Sen University Cancer Center, 4Departments of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, People’s Republic of China  *These authors contributed equally to this work Background: Triple-ne...

  10. A Method to Measure the Amount of Battlefield Situation Information

    Science.gov (United States)

    2014-06-01

    log)( 20 atS  3.2 Measurement of trends information Kierkegaard once said “Life can only be understood backwards, but it must be lived forwards” [8...Towards a theory of s 10 11 , “The Journals of Soren Kierkegaard ”, A selection and translated by Alexander chun, “Formal Description of Command...and 37(2), pp32-64, 1995. [8] Kierkegaard , Soren – Dru , Oxford: Oxford University Press (1938). pp465 [9] ZHOU Dao-an, ZHANG Dong-ge, CHANG Shu

  11. Development of Nanostructure Materials and Architecture for High Performance Li-rechargeable Batteries with Ultrafast Charge Rate

    Science.gov (United States)

    2011-04-22

    overcome these difficulties extensive work has been done. Surface coatings with ZnO , SiO2, and Bi2O3 have been proposed to enhance stability of electrodes...Liu, G. Q.; Wen, L.; Liu, Y. M. Journal of Solid State Electrochemistry 2010, 14, 2191. (23) Myung, S. T.; Komaba, S.; Kumagai, N.; Yashiro, H.; Chung...Y. R.; Shu, J.; Zhu, R. S. Journal of Solid State Electrochemistry 2009, 13, 913. (29) Aklalouch, M.; Amarilla, J. M.; Rojas, R. M.; Saadoune, I

  12. Analysis list: CBP [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available CBP Adult,Cell line,Embryo,Larvae,Pupae + dm3 http://dbarchive.biosciencedbc.jp/kyu...shu-u/dm3/target/CBP.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/CBP.5.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/target/CBP.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/CBP.Adul...t.tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/CBP.Cell_line.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/CBP.Embryo.tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/dm3

  13. Analysis list: ZFX [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ZFX Blood,Neural + hg19 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/ZFX....1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/ZFX.5.tsv http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/target/ZFX.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/ZFX.Blood.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/hg19/colo/ZFX.Neural.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/hg19/colo/Blood.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/Neural.gml ...

  14. Electroacupuncture for patients with diarrhea-predominant irritable bowel syndrome or functional diarrhea: A randomized controlled trial.

    Science.gov (United States)

    Zheng, Hui; Li, Ying; Zhang, Wei; Zeng, Fang; Zhou, Si-Yuan; Zheng, Hua-Bin; Zhu, Wen-Zeng; Jing, Xiang-Hong; Rong, Pei-Jing; Tang, Chun-Zhi; Wang, Fu-Chun; Liu, Zhi-Bin; Wang, Shi-Jun; Zhou, Mei-Qi; Liu, Zhi-Shun; Zhu, Bing

    2016-06-01

    Diarrhea-predominant irritable bowel syndrome (IBS-D) and functional diarrhea (FD) are highly prevalent, and the effectiveness of acupuncture for managing IBS-D and FD is still unknown.The aim of this study was to compare the effectiveness of electroacupuncture with loperamide.It was a prospective, randomized, parallel group controlled trial.A total of 448 participants were randomly assigned to He electroacupuncture group (n = 113), Shu-Mu electroacupuncture group (n = 111), He-Shu-Mu electroacupuncture group (n = 112), or loperamide group (n = 112). Participants in the 3 acupuncture groups received 16 sessions of electroacupuncture during a 4-week treatment phase, whereas participants in the loperamide group received oral loperamide 2 mg thrice daily. The primary outcome was the change from baseline in stool frequency at the end of the 4-weeks treatment. The secondary outcomes were the Bristol scale, the MOS 36-item short form health survey (SF-36), the weekly average number of days with normal defecations and the proportion of adverse events.Stool frequency was significantly reduced at the end of the 4-week treatment in the 4 groups (mean change from baseline, 5.35 times/week). No significant difference was found between the 3 electroacupuncture groups and the loperamide group in the primary outcome (He vs. loperamide group [mean difference 0.6, 95% CI, -1.2 to 2.4]; Shu-Mu vs. loperamide group [0.4, 95% CI, -1.4 to 2.3]; He-Shu-Mu vs. loperamide group [0.0, 95% CI, -1.8 to 1.8]). Both electroacupuncture and loperamide significantly improved the mean score of Bristol scale and increased the weekly average number of days with normal defecations and the mean scores of SF-36; they were equivalent in these outcomes. However, the participants in electroacupuncture groups did not report fewer adverse events than those in the loperamide group. Similar results were found in a subgroup analysis of separating patients with IBS-D and FD patients.Electroacupuncture is

  15. Maximally efficient two-stage screening: Determining intellectual disability in Taiwanese military conscripts

    OpenAIRE

    Chien, Chia-Chang; Huang, Shu-Fen; Lung, For-Wey

    2009-01-01

    Chia-Chang Chien1, Shu-Fen Huang1,2,3,4, For-Wey Lung1,2,3,41Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan; 2Graduate Institute of Behavioral Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan; 3Department of Psychiatry, National Defense Medical Center, Taipei, Taiwan; 4Calo Psychiatric Center, Pingtung County, TaiwanObjective: The purpose of this study was to apply a two-stage screening method for the large-scale intelligence screening of militar...

  16. A Survey of Cyber Ranges and Testbeds

    Science.gov (United States)

    2013-10-01

    2012. [8] S. W. Neville and K. F. Li , "The Rational for Developing Larger-scale 1000+ Machine Emulation-Based Research Test Beds," WAINA 2009, pp...2002, pp. 6-2671-2676, 6-2678-6- 2682 vol. 6. [20] P. Pederson, D. Lee, G. Shu, D. Chen, Z. Liu, N. Li , and L. Sang, "Virtual Cyber- Security Testing...attacks with applications in homeland defense training." AeroSense 2003. International Society for Optics and Photonics, 2003. [54] Zhou, Mian

  17. Microangiopatias trombóticas: púrpura trombocitopênica trombótica e síndrome hemolítico-urêmica Thrombotic microangiopathies: thrombotic thrombocytopenic purpura / hemolytic uremic syndrome

    Directory of Open Access Journals (Sweden)

    Maria Goretti Polito

    2010-09-01

    Full Text Available As microangiopatias trombóticas (MATs são condições caracterizadas por oclusão microvascular generalizada por trombos de plaquetas, trombocitopenia, e anemia hemolítica microangiopática. Duas manifestações fenotípicas típicas das MATs são a síndrome hemolítica urêmica (SHU e a púrpura trombocitopênica trombótica (PTT. Outras doenças ocasionalmente apresentam manifestações similares. Na dependência de prevalecer a lesão renal ou a cerebral, duas entidades patologicamente indistinguíveis, mas de alguma forma clinicamente diferentes, têm sido descritas: a SHU e a PTT. Injúria das células endoteliais é o fator desencadeante central na sequência de eventos que levam a MAT. Perda da trombo resistência fisiológica, adesão de leucócitos no endotélio lesado, consumo de complemento, liberação e fragmentação anormais do fator de von Willebrand (FvW, e aumento do estresse de cisalhamento vascular podem sustentar e ampliar o processo microangiopático. Anormalidades intrínsecas do sistema do complemento e do FvW podem acompanhar a predisposição genética à doença, que pode ter um papel chave, em particular nas formas recorrentes e familiares. Nos casos de SHU associada à diarreia (SHU+D, o dano endotelial renal é mediado (pelo menos em parte pela Shigatoxina (Stx bacteriana, uma família de toxinas elaboradas por certas cepas da Escherichia coli e Shigella dysenteriae. A evolução é geralmente boa na criança, na SHU associada a Stx, enquanto sequelas renais e neurológicas são mais frequentemente encontradas em adultos, formas familiares e atípicas da SHU e na PTT. Estudos recentes têm demonstrado que a deficiência na clivagem do FvW pela proteinase ADAMTS13 pode ser genética ou mais comumente adquirida, resultante da produção de anticorpos inibidores da ADAMTS13, causando a PTT. Durante a última década, demonstrou-se que a SHU atípica (SHU-D é uma doença de desregulação da via alternativa do

  18. Bibliometric analysis of martial arts monographs published in Spain (1906-2006

    Directory of Open Access Journals (Sweden)

    Mikel Pérez Gutiérrez

    2012-07-01

    Full Text Available This paper examines the martial arts monographs published in Spain between 1906 and 2006 from a bibliometric point of view. Starting from Pérez and Gutiérrez’s previous bibliography (2008, the total number of published monographs following the criteria of subject, decade and the combination of both was analyzed. The results showed a total of 2.036 books (1.285 original editions with a prevalence of Japanese and Chinese martial arts. A group of eight subjects exceeded a hundred volumes (karate, judo/jujutsu, taijiquan, wu-shu/kung fu, classics, qigong, philosophy, history and education, and aikido, with two patterns of bibliographic evolution appearing. The first, represented by Japanese martial arts considered as a group and martial arts focused on the utilitarian and/or sporting performance aspects (judo/jujutsu, karate and wu-shu/kung fu, developed increasingly until the 80’s when it followed a steady-state and/or drop. The second model, which characterises the Chinese martial arts group and martial arts mainly focused on healthy and/or spiritual aspects of training (taijiquan, qigong, aikido, has increased significantly from the 90’s until the present moment. The interpretation of these patterns and the evolution of the martial arts bibliographic production in Spain highlights some aspects such as the development of the Spanish society and sports practice, bibliographic production, reading habits, or the cultural influences of eastern countries on Spain.

  19. Simulation of Thermal Flow Problems via a Hybrid Immersed Boundary-Lattice Boltzmann Method

    Directory of Open Access Journals (Sweden)

    J. Wu

    2012-01-01

    Full Text Available A hybrid immersed boundary-lattice Boltzmann method (IB-LBM is presented in this work to simulate the thermal flow problems. In current approach, the flow field is resolved by using our recently developed boundary condition-enforced IB-LBM (Wu and Shu, (2009. The nonslip boundary condition on the solid boundary is enforced in simulation. At the same time, to capture the temperature development, the conventional energy equation is resolved. To model the effect of immersed boundary on temperature field, the heat source term is introduced. Different from previous studies, the heat source term is set as unknown rather than predetermined. Inspired by the idea in (Wu and Shu, (2009, the unknown is calculated in such a way that the temperature at the boundary interpolated from the corrected temperature field accurately satisfies the thermal boundary condition. In addition, based on the resolved temperature correction, an efficient way to compute the local and average Nusselt numbers is also proposed in this work. As compared with traditional implementation, no approximation for temperature gradients is required. To validate the present method, the numerical simulations of forced convection are carried out. The obtained results show good agreement with data in the literature.

  20. Development of a discrete gas-kinetic scheme for simulation of two-dimensional viscous incompressible and compressible flows.

    Science.gov (United States)

    Yang, L M; Shu, C; Wang, Y

    2016-03-01

    In this work, a discrete gas-kinetic scheme (DGKS) is presented for simulation of two-dimensional viscous incompressible and compressible flows. This scheme is developed from the circular function-based GKS, which was recently proposed by Shu and his co-workers [L. M. Yang, C. Shu, and J. Wu, J. Comput. Phys. 274, 611 (2014)]. For the circular function-based GKS, the integrals for conservation forms of moments in the infinity domain for the Maxwellian function-based GKS are simplified to those integrals along the circle. As a result, the explicit formulations of conservative variables and fluxes are derived. However, these explicit formulations of circular function-based GKS for viscous flows are still complicated, which may not be easy for the application by new users. By using certain discrete points to represent the circle in the phase velocity space, the complicated formulations can be replaced by a simple solution process. The basic requirement is that the conservation forms of moments for the circular function-based GKS can be accurately satisfied by weighted summation of distribution functions at discrete points. In this work, it is shown that integral quadrature by four discrete points on the circle, which forms the D2Q4 discrete velocity model, can exactly match the integrals. Numerical results showed that the present scheme can provide accurate numerical results for incompressible and compressible viscous flows with roughly the same computational cost as that needed by the Roe scheme.

  1. Clearance of iron oxide particles in rat liver: effect of hydrated particle size and coating material on liver metabolism.

    Science.gov (United States)

    Briley-Saebo, Karen C; Johansson, Lars O; Hustvedt, Svein Olaf; Haldorsen, Anita G; Bjørnerud, Atle; Fayad, Zahi A; Ahlstrom, Haakan K

    2006-07-01

    We sought to evaluate the effect of the particle size and coating material of various iron oxide preparations on the rate of rat liver clearance. The following iron oxide formulations were used in this study: dextran-coated ferumoxide (size = 97 nm) and ferumoxtran-10 (size = 21 nm), carboxydextran-coated SHU555A (size = 69 nm) and fractionated SHU555A (size = 12 nm), and oxidized-starch coated materials either unformulated NC100150 (size = 15 nm) or formulated NC100150 injection (size = 12 nm). All formulations were administered to 165 rats at 2 dose levels. Quantitative liver R2* values were obtained during a 63-day time period. The concentration of iron oxide particles in the liver was determined by relaxometry, and these values were used to calculate the particle half-lives in the liver. After the administration of a high dose of iron oxide, the half-life of iron oxide particles in rat liver was 8 days for dextran-coated materials, 10 days for carboxydextran materials, 14 days for unformulated oxidized-starch, and 29 days for formulated oxidized-starch. The results of the study indicate that materials with similar coating but different sizes exhibited similar rates of liver clearance. It was, therefore, concluded that the coating material significantly influences the rate of iron oxide clearance in rat liver.

  2. 马其昶古文论%Ma Qichang's Ancient Literary Theory

    Institute of Scientific and Technical Information of China (English)

    潘务正

    2013-01-01

    马其昶有桐城派古文“殿军”的美誉,其文深受林纾、陈宝琛、章太炎等遗老或激进思想家的推崇。其古文多抒发身处易代之际的哀婉、感伤之情,又善言情,出之以六一风神,能尽俗且多施博喻,故而有较强的感染力。林纾等人推举其为当时第一作手,并非虚誉。%Ma Qichang is honored as an ancient literary “rear guard”of Tongcheng School of literature. His writings are highly praised by Lin Shu, Chen Baochen, Zhang Taiyan, and redical thinkers. And his writings express pathetic and sentimental emotion as well as romance, which generate remarkable artistic appeal. Lin Shu and so on promoted him as the first class writer.

  3. Improvement of Theme Park Marketing Mode:A Case Study of Theme Parks in Chengdu

    Institute of Scientific and Technical Information of China (English)

    Min; LI; Gaoli; XIONG

    2013-01-01

    Construction of theme park has been launched since the early 1990s in Chengdu City,but ended up as a losing proposition after its short-term prosperity because of similar scale and similarity with those in other cities.As more international well-known theme parks entering the market,theme parks in Chengdu have been faced with the transition,and novel concepts are also introduced into the operation of these parks.To adapt to the market,it is imperative to make marketing strategies and combine marketing elements.Through analyzing current development of local theme parks and introducing successful marketing modes of domestic and overseas theme parks,a favorable marketing mode for theme parks in Chengdu was defined on the basis of fully exploring Ba-Shu culture(Ba and Shu are two ancient kingdoms in the history of Sichuan).By defining a favorable theme,focusing more on visitors’experience,devoting more in developing new products,adopting flexible price strategies,and integrating advertisement marketing,internet marketing,and other marketing methods,outstanding brands will be formed,and tourism cultures with distinguished features of Chengdu will be created.

  4. Mapping DNA damage-dependent genetic interactions in yeast via party mating and barcode fusion genetics.

    Science.gov (United States)

    Díaz-Mejía, J Javier; Celaj, Albi; Mellor, Joseph C; Coté, Atina; Balint, Attila; Ho, Brandon; Bansal, Pritpal; Shaeri, Fatemeh; Gebbia, Marinella; Weile, Jochen; Verby, Marta; Karkhanina, Anna; Zhang, YiFan; Wong, Cassandra; Rich, Justin; Prendergast, D'Arcy; Gupta, Gaurav; Öztürk, Sedide; Durocher, Daniel; Brown, Grant W; Roth, Frederick P

    2018-05-28

    Condition-dependent genetic interactions can reveal functional relationships between genes that are not evident under standard culture conditions. State-of-the-art yeast genetic interaction mapping, which relies on robotic manipulation of arrays of double-mutant strains, does not scale readily to multi-condition studies. Here, we describe barcode fusion genetics to map genetic interactions (BFG-GI), by which double-mutant strains generated via en masse "party" mating can also be monitored en masse for growth to detect genetic interactions. By using site-specific recombination to fuse two DNA barcodes, each representing a specific gene deletion, BFG-GI enables multiplexed quantitative tracking of double mutants via next-generation sequencing. We applied BFG-GI to a matrix of DNA repair genes under nine different conditions, including methyl methanesulfonate (MMS), 4-nitroquinoline 1-oxide (4NQO), bleomycin, zeocin, and three other DNA-damaging environments. BFG-GI recapitulated known genetic interactions and yielded new condition-dependent genetic interactions. We validated and further explored a subnetwork of condition-dependent genetic interactions involving MAG1 , SLX4, and genes encoding the Shu complex, and inferred that loss of the Shu complex leads to an increase in the activation of the checkpoint protein kinase Rad53. © 2018 The Authors. Published under the terms of the CC BY 4.0 license.

  5. [Study on the excavated wooden carved acupuncture statue of the Western Han Dynasty in Laoguanshan].

    Science.gov (United States)

    Huang, L X

    2017-05-28

    The painted red lines on the wooden carved acupuncture statue of Western Han Dynasty in Laoguanshan, illustrate the running courses of the"eleven meridians"on the body surface in the early meridian doctrine. The carved white lines show the body surface running courses of the"twelve meridians"in the meridian doctrine and the Sanjiao images in Sanjiao doctrine. The dots on the wooden carved acupuncture statue are of two categories, one of them is of regulatory, round and concave spots, which are carved before the process of lacquer undercoat. The other category is of different sizes and in irregular forms, which are carved simultaneously with those white lines. Altogether there are over one hundred dots in these two categories, representing the mai shu (transport point of vessels). The wooden carved acupuncture statue reflects the distinct characteristics on the running courses of meridians, Sanjiao doctrine, the nomenclature and localization of" mai shu "in Bianque medicine, which provides the most powerful evidence for the confirmation of the correlation between Laoguanshan excavated documents and Bianque medicine.

  6. Forgotten Features of Head Zones and Their Relation to Diagnostically Relevant Acupuncture Points

    Directory of Open Access Journals (Sweden)

    Florian Beissner

    2011-01-01

    Full Text Available In the 1890s Sir Henry Head discovered certain areas of the skin that develop tenderness (allodynia in the course of visceral disease. These areas were later termed “Head zones”. In addition, he also emphasized the existence of specific points within these zones, that he called “maximum points”, a finding that seems to be almost forgotten today. We hypothesized that two important groups of acupuncture points, the diagnostically relevant Mu and Shu points, spatially and functionally coincide with these maximum points to a large extent. A comparison of Head's papers with the Huang Di Neijing (Yellow Thearch's Inner Classic and the Zhen Jiu Jia Yi Jing (Systematic Classic of Acupuncture and Moxibustion, two of the oldest still extant Chinese sources on acupuncture, revealed astonishing parallels between the two concepts regarding both point locations and functional aspects. These findings suggest that the Chinese discovery of viscerocutaneous reflexes preceded the discovery in the West by more than 2000 years. Furthermore, the fact that Chinese medicine uses Mu and Shu points not only diagnostically but also therapeutically may give us new insights into the underlying mechanisms of acupuncture.

  7. Regulation of hepatic PPARγ2 and lipogenic gene expression by melanocortin

    International Nuclear Information System (INIS)

    Poritsanos, Nicole J.; Wong, Davie; Vrontakis, Maria E.; Mizuno, Tooru M.

    2008-01-01

    The central melanocortin system regulates hepatic lipid metabolism. Hepatic lipogenic gene expression is regulated by transcription factors including sterol regulatory element-binding protein 1c (SREBP-1c), carbohydrate responsive element-binding protein (ChREBP), and peroxisome proliferator-activated receptor γ2 (PPARγ2). However, it is unclear if central melanocortin signaling regulates hepatic lipogenic gene expression through the activation of these transcription factors. To delineate the molecular mechanisms by which the melanocortin system regulates hepatic lipid metabolism, we examined the effect of intracerebroventricular injection of SHU9119, a melanocortin receptor antagonist, on hepatic expression levels of genes involved in lipid metabolism in mice. SHU9119 treatment increased hepatic triglyceride content and mRNA levels of lipogenic genes, SREBP-1c, and PPARγ2, whereas it did not cause any changes in hepatic ChREBP mRNA levels. These findings suggest that reduced central melanocortin signaling increases hepatic lipid deposition by stimulating hepatic lipogenic gene expression at least partly through the activation of SREBP-1c and PPARγ2

  8. Grating-based X-ray Dark-field Computed Tomography of Living Mice.

    Science.gov (United States)

    Velroyen, A; Yaroshenko, A; Hahn, D; Fehringer, A; Tapfer, A; Müller, M; Noël, P B; Pauwels, B; Sasov, A; Yildirim, A Ö; Eickelberg, O; Hellbach, K; Auweter, S D; Meinel, F G; Reiser, M F; Bech, M; Pfeiffer, F

    2015-10-01

    Changes in x-ray attenuating tissue caused by lung disorders like emphysema or fibrosis are subtle and thus only resolved by high-resolution computed tomography (CT). The structural reorganization, however, is of strong influence for lung function. Dark-field CT (DFCT), based on small-angle scattering of x-rays, reveals such structural changes even at resolutions coarser than the pulmonary network and thus provides access to their anatomical distribution. In this proof-of-concept study we present x-ray in vivo DFCTs of lungs of a healthy, an emphysematous and a fibrotic mouse. The tomographies show excellent depiction of the distribution of structural - and thus indirectly functional - changes in lung parenchyma, on single-modality slices in dark field as well as on multimodal fusion images. Therefore, we anticipate numerous applications of DFCT in diagnostic lung imaging. We introduce a scatter-based Hounsfield Unit (sHU) scale to facilitate comparability of scans. In this newly defined sHU scale, the pathophysiological changes by emphysema and fibrosis cause a shift towards lower numbers, compared to healthy lung tissue.

  9. Numerical study on the convergence to steady state solutions of a new class of high order WENO schemes

    Science.gov (United States)

    Zhu, Jun; Shu, Chi-Wang

    2017-11-01

    A new class of high order weighted essentially non-oscillatory (WENO) schemes (Zhu and Qiu, 2016, [50]) is applied to solve Euler equations with steady state solutions. It is known that the classical WENO schemes (Jiang and Shu, 1996, [23]) might suffer from slight post-shock oscillations. Even though such post-shock oscillations are small enough in magnitude and do not visually affect the essentially non-oscillatory property, they are truly responsible for the residue to hang at a truncation error level instead of converging to machine zero. With the application of this new class of WENO schemes, such slight post-shock oscillations are essentially removed and the residue can settle down to machine zero in steady state simulations. This new class of WENO schemes uses a convex combination of a quartic polynomial with two linear polynomials on unequal size spatial stencils in one dimension and is extended to two dimensions in a dimension-by-dimension fashion. By doing so, such WENO schemes use the same information as the classical WENO schemes in Jiang and Shu (1996) [23] and yield the same formal order of accuracy in smooth regions, yet they could converge to steady state solutions with very tiny residue close to machine zero for our extensive list of test problems including shocks, contact discontinuities, rarefaction waves or their interactions, and with these complex waves passing through the boundaries of the computational domain.

  10. Síndrome hemolítico-urêmica causada por gencitabina em uma paciente jovem com colangiocarcinoma

    Directory of Open Access Journals (Sweden)

    John Fredy Nieto-Ríos

    2016-06-01

    Full Text Available Resumo A gencitabina é um fármaco utilizado no tratamento de vários tipos de neoplasias malignas. Há poucas descrições de associação entre a droga e a síndrome hemolítico-urêmica (SHU, apesar de os pacientes em questão terem ido a óbito em pelo menos 50% dos casos. O presente artigo relata o caso de uma paciente com 25 anos de idade em remissão diagnosticada com colangiocarcinoma que apresentou anemia hemolítica microangiopática acompanhada de insuficiência renal aguda anúrica após cinco ciclos de quimioterapia com gencitabina; as manifestações eram condizentes com SHU causada pelos efeitos colaterais do medicamento. A administração de gencitabina foi interrompida, e a paciente foi tratada com hemodiálise, transfusões de sangue, trocas de plasma, corticosteroides, doxiciclina e rituximabe. Foi atingido um desfecho favorável; mais especificamente, a hemólise foi controlada e a função renal foi plenamente restabelecida.

  11. Reticuloendothelial negative contrast media for hepatocellular carcinoma. Initial comparison of chondroitin sulfate iron colloid and Ferrixan in fast T2-weighted MR imaging

    International Nuclear Information System (INIS)

    Sugihara, Shuji; Suto, Yuji; Kamba, Masayuki; Yoshida, Kotaro

    1996-01-01

    Chondroitin sulfate iron colloid (CSIC), a paramagnetic substance, and Ferrixan (SHU555A), a superparamagnetic substance, were administered to 20 patients with 26 nodules of hepatocellular carcinoma, and the visualization of the lesions by fast T2-weighted magnetic resonance imaging (MRI) was quantitatively evaluated. Conventional spin-echo (CSE), turbo spin-echo (TSE), and turbo gradient spin-echo (TGSE) sequences were performed in all patients before and after the administration of the iron colloid preparations. The signal-to-noise ratio (SNR) in the liver decreased significantly after administration of iron colloid preparations by all sequences and at all doses. A reduction in SNR in the liver similar to that obtained with SHU555A could be obtained by increasing the dose of CSIC, which has a weaker T2-shortening effect. In the TSE sequence with a weaker susceptibility effect, the decrease in SNR in the liver tended to be equalized to those in the CSE or TGSE sequences by high dose administration of the iron colloid preparation. We think perhaps that the imaging ability for hepatocellular carcinoma, similar to that of superparamagnetic contrast media, can be obtained with paramagnetic CSIC by administering it at a higher dose. (author)

  12. Reticuloendothelial negative contrast media for hepatocellular carcinoma. Initial comparison of chondroitin sulfate iron colloid and Ferrixan in fast T2-weighted MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Sugihara, Shuji; Suto, Yuji; Kamba, Masayuki; Yoshida, Kotaro [Tottori Univ., Yonago (Japan). Faculty of Medicine

    1996-11-01

    Chondroitin sulfate iron colloid (CSIC), a paramagnetic substance, and Ferrixan (SHU555A), a superparamagnetic substance, were administered to 20 patients with 26 nodules of hepatocellular carcinoma, and the visualization of the lesions by fast T2-weighted magnetic resonance imaging (MRI) was quantitatively evaluated. Conventional spin-echo (CSE), turbo spin-echo (TSE), and turbo gradient spin-echo (TGSE) sequences were performed in all patients before and after the administration of the iron colloid preparations. The signal-to-noise ratio (SNR) in the liver decreased significantly after administration of iron colloid preparations by all sequences and at all doses. A reduction in SNR in the liver similar to that obtained with SHU555A could be obtained by increasing the dose of CSIC, which has a weaker T2-shortening effect. In the TSE sequence with a weaker susceptibility effect, the decrease in SNR in the liver tended to be equalized to those in the CSE or TGSE sequences by high dose administration of the iron colloid preparation. We think perhaps that the imaging ability for hepatocellular carcinoma, similar to that of superparamagnetic contrast media, can be obtained with paramagnetic CSIC by administering it at a higher dose. (author)

  13. Researches on Mathematical Relationship of Five Elements of Containing Notes and Fibonacci Sequence Modulo 5

    Directory of Open Access Journals (Sweden)

    Zhaoxue Chen

    2015-01-01

    Full Text Available Considering the five periods and six qi’s theory in TCM almost shares a common basis of stem-branch system with the five elements of containing notes, studying the principle or mathematical structure behind the five elements of containing notes can surely bring a novel view for the five periods and six qi’s researches. By analyzing typical mathematical rules included in He tu, Luo shu, and stem-branch theory in TCM as well as the Fibonacci sequence especially widely existent in the biological world, novel researches are performed on mathematical relationship between the five elements of containing notes and the Fibonacci sequence modulo 5. Enlightened by elementary Yin or Yang number grouping principle of He tu, Luo shu, the 12534 and 31542 key number series of Fibonacci sequence modulo 5 are obtained. And three new arrangements about the five elements of containing notes are then introduced, which have shown close relationship with the two obtained key subsequences of the Fibonacci sequence modulo 5. The novel discovery is quite helpful to recover the scientific secret of the five periods and six qi’s theory in TCM as well as that of whole traditional Chinese culture system, but more data is needed to elucidate the TCM theory further.

  14. Comparative safety testing of genetically modified foods in a 90-day rat feeding study design allowing the distinction between primary and secondary effects of the new genetic event

    DEFF Research Database (Denmark)

    Knudsen, Ib; Poulsen, Morten

    2007-01-01

    ., Frenzel, T., Danier, J., Rychlik, M., Shu, Q., Emami, K., Taylor, M., Gatehouse, A., Engel, K.-H., Knudsen, I., 2007a. Safety testing of GM-rice expressing PHA-E lectin using a new animal test design. Food Chem. Toxicol. 45, 364-377; Poulsen, M., Kroghsbo, S., Schroder, M., Wilcks, A., Jacobsen, H...... to separate potentially unintended effects of the novel gene product from other unintended effects at the level of intake defined in the test and within the remit of the test. Recommendations for further work necessary in the field are given.......This article discusses the wider experiences regarding the usefulness of the 90-day rat feeding study for the testing of whole foods from genetically modified (GM) plant based on data from a recent EU-project [Poulsen, M., Schroder, M., Wilcks, A., Kroghsbo, S., Lindecrona, R.H., Miller, A...

  15. PREDIKSI FINANCIAL DISTRESS PADA KOPERASI DI KABUPATEN PEMALANG

    Directory of Open Access Journals (Sweden)

    Sukirno Sukirno

    2014-05-01

    Full Text Available This paper examines the usefulness of financial statements to predict financial distress in thecooperative. The financial distress is a condition before the bankruptcy that can be seen inthe financial statements. Furthermore, the financial statements are being analyzed using ratioanalysis. The ratio analysis  used as a predictor variable are current ratio, quick ratio, currentassets to total assets ratio, current liabilities to total assets, net profit margin ratio and net SHUto total assets ratio. While the research object is a cooperative financial statements reported on2012. There are 63 cooperatives used as the sample with purposive sampling approach. Thehypothesis is analysed using logistic regression. The results found that three variables can be used to predict financial distress of the cooperative. Those variables are ratio of current assets to total assets, current liabilities to total assets and net SHU to total assets. This implies theusefulnes of financial ratio to predict financial distress in the cooperative.

  16. Lanthanide metal-organic frameworks

    International Nuclear Information System (INIS)

    Cheng, Peng

    2015-01-01

    This book contains the following nine chapters: lanthanide metal-organic frameworks: syntheses, properties, and potential applications (Stephen Fordham, Xuan Wang, Mathieu Bosch, Hong-Cai Zhou); 2. chiral lanthanide metal-organic frameworks (Weisheng Liu, Xiaoliang Tang); 3. Porous lanthanide metal-organic frameworks for gas storage and separation (Bin Li, Banglin Chen); 4. Luminescent lanthanide metal-organic frameworks (Xue-Zhi Song, Shu-Yan Song, Hong-Jie Zhang); 5. Metal-organic frameworks based on lanthanide clusters (Lian Chen, Feilong Jiang, Kang Zhou, Mingyan Wu, Maochun Hong); 6. metal-organic frameworks with d-f cyanide bridges: structural diversity, bonding regime, and magnetism (Marilena Ferbinteanu, Fanica Cimpoesu, Stefania Tanase); 7. transition-lanthanide heterometal-organic frameworks: synthesis, structures, and properties (Wei Shi, Ke Liu, Peng Cheng); 8: MOFs of uranium and the actinides (Juan Su, Jiesheng Chen); 9. Nanostructured and/or nanoscale lanthanide metal-organic frameworks (Zhonghao Zhang, Zhiping Zheng).

  17. Efectos de un entrenamiento pliométrico en extremidades superiores e inferiores en el rendimiento físico en jóvenes tenistas. [Effects of upper and lower body plyometric training on physical performance in young tennis players].

    Directory of Open Access Journals (Sweden)

    Elena Pardos-Mainer

    2017-07-01

    Full Text Available El objetivo del presente estudio fue evaluar el efecto de un entrenamiento pliométrico (ejercicios en extremidades superiores e inferiores en acciones físicas explosivas específicas en jóvenes tenistas. Veintiún jóvenes tenistas (11 chicos, 10 chicas; media de edad 14.33 ± 1.77 años participaron en el presente estudio y fueron divididos de forma no aleatoria en grupo control, el cual continuó con su entrenamiento habitual de preparación física y en experimental, al que se le sustituyó su entrenamiento de preparación física habitual por un programa de entrenamiento pliométrico dos veces por semana durante un período de 8 semanas. Las variables de rendimiento fueron analizadas a través de diferentes valoraciones: un sprint de 20 metros (tiempos parciales 5m, 10m y 15m, un sprint de 5 + 5 metros con un cambio de dirección de 180º, un test de salto con contramovimiento bilateral (CMJ y unilateral, un test de lanzamiento de balón medicinal a la máxima distancia (BM, un test de velocidad de servicio y un test de salto horizontal bilateral (SH y unilateral (SHU. El efecto producido por el entrenamiento fue calculado en base al tamaño del efecto. Todas las variables de rendimiento fueron mejoradas en ambos grupos en comparación con los valores del pre-test. Además, el grupo experimental obtuvo mejoras sustanciales con respecto al grupo control en el SH, SHU, CMJ Y BM. Por lo tanto, el programa de entrenamiento pliométrico podría considerarse como un estímulo efectivo en la mejora de las acciones explosivas en jóvenes tenistas. Abstract The aim of the current study was to assess the effect of plyometric training (upper and lower body exercises in explosive actions in young tennis players. Twenty-one young tennis players (11 males, 10 females, age 14.33 ± 1.77 years old participated in the present study and were divided, in a non-randomized manner, into a control group which continued with a regular physical training and in a

  18. [Professor WANG Linpeng's experience of acupuncture for migraine based on different stages and types].

    Science.gov (United States)

    Wang, Shaosong

    2016-07-12

    By using the methods of experience summary and case report, professor WANG Linpeng 's clinical experience of acupuncture for migraine was summarized.Professor WANG proposed the different acupuncture plans should be established according to the active stage and remission stage of migraine; in the active stage acupuncture should be applied at gallbladder meridian with penetration needling technique to reinforce the stimulation intensity; in the remission stage the aim was to regulate zang-fu and back- shu points should be emphasized.In addition, attention should be paid on acupuncture technique and preventive treatment.For menstruation-type and psychological disorder-type migraine, different acupuncture plans should be adopted and regulating meridian and spirit was essential in the treatment.

  19. NB Coating Developments with HIPIMS for SRF Applications

    CERN Document Server

    Terenziani, G; Junginger, T; Santillana, I A; Ehiasarian, A P

    2013-01-01

    In the last few years the interest of the thin film science and technology community on High Impulse Power Magnetron Sputtering (HIPIMS) coatings has steadily increased. HIPIMS literature shows that better thin film morphology, denser and smoother films can be achieved when compared with standard dc Magnetron Sputtering (dcMS) coating technology [1]. Furthermore the capability of HIPIMS to produce a high quantity of ionized species [2,3] can allow conformal coatings also for complex geometries. A study is under way at CERN to apply this technology for the Nb coating of SRF 1.3-1.5 GHz Cu cavities, and in parallel at SHU the plasma physics and its correlation with film morphology are being investigated [2]. Recent results achieved with this technique are presented in the paper.

  20. A second order discontinuous Galerkin fast sweeping method for Eikonal equations

    Science.gov (United States)

    Li, Fengyan; Shu, Chi-Wang; Zhang, Yong-Tao; Zhao, Hongkai

    2008-09-01

    In this paper, we construct a second order fast sweeping method with a discontinuous Galerkin (DG) local solver for computing viscosity solutions of a class of static Hamilton-Jacobi equations, namely the Eikonal equations. Our piecewise linear DG local solver is built on a DG method developed recently [Y. Cheng, C.-W. Shu, A discontinuous Galerkin finite element method for directly solving the Hamilton-Jacobi equations, Journal of Computational Physics 223 (2007) 398-415] for the time-dependent Hamilton-Jacobi equations. The causality property of Eikonal equations is incorporated into the design of this solver. The resulting local nonlinear system in the Gauss-Seidel iterations is a simple quadratic system and can be solved explicitly. The compactness of the DG method and the fast sweeping strategy lead to fast convergence of the new scheme for Eikonal equations. Extensive numerical examples verify efficiency, convergence and second order accuracy of the proposed method.

  1. Analytical W–He and H–He interatomic potentials for a W–H–He system

    International Nuclear Information System (INIS)

    Li Xiaochun; Shu Xiaolin; Liu Yinan; Yu Yi; Gao, F.; Lu Guanghong

    2012-01-01

    We have constructed W–He and H–He analytical bond-order potentials for a W–H–He system. In combination with the previously self-developed W–H potential [X.-C. Li, X. Shu, Y.-N. Liu, F. Gao, G.-H. Lu, J. Nucl. Mater. 408 (2011) 12] and the Hartree–Fock-dispersion pair potential (Aziz-potential) for He−He interactions, we demonstrate that such potentials behave well for reproducing various properties of the W–H–He system such as defect formation energies, structural properties, and diffusion barriers. Such potentials can be employed to model both the He behaviours and the H–He synergetic effects in the W–H–He system.

  2. [Observation on therapeutic effect of catgut implantation at acupoints on exercise fatigue and study on the mechanism].

    Science.gov (United States)

    Chen, Yong-Zhen; Xu, Yi; Yang, Wei-Bin; Lü, Yi-Hao; Fang, Hai-Bo

    2008-09-01

    To probe into the therapeutic effect of catgut implantation at acupoint on exercise fatigue and to study on the mechanism. Catgut implantation was given at main points Guanyuan (CV 4), Shen shu (BL 23), Mingmen (GV 4), Zusanli (ST 36), Sanyinjiao (SP 6) in 41 players during training for 2 courses. Training-related condition and changes of blood testosterone (T) and hemoglobin (Hb) before and after training were observed. After treatment, sleeping quality, the mental state at the time of getting out of bed in the morning, appetite, training wish, training stamina, training quality, training attention, etc. in the player significantly improved, and blood T and Hb levels significantly increased. Catgut implantation at acupoints can significantly improve exercise fatigue in the player and the mechanism is possibly related with increase of testosterone and hemoglobin levels.

  3. Cesarean scar pregnancy treated by curettage and aspiration guided by laparoscopy

    Directory of Open Access Journals (Sweden)

    Shu S

    2015-08-01

    Full Text Available Shan-rong Shu, Xin Luo, Zhi-xin Wang, Yu-hong Yao Department of Obstetrics and Gynecology, The First Affiliated Hospital of JiNan University, HuangPu Road West, Guangzhou, People’s Republic of China Abstract: Pregnancy in a cesarean scar is the rarest form of an ectopic pregnancy. The treatment for cesarean scar pregnancy mainly includes systemic methotrexate and uterine artery embolization. Here, we reported a case of cesarean scar pregnancy treated by curettage and aspiration guided by laparoscopy. The treatment plan included two phases. Three days after a combination of methotrexate and mifepristone was administered, the gestational sac was removed under laparoscopy, which enabled a successful treatment for the unruptured ectopic pregnancy in a previous cesarean scar and made it possible to preserve the reproductive capability of the patient. Keywords: cesarean scar pregnancy, laparoscopy, curettage and aspiration 

  4. Information systems and computing technology

    CERN Document Server

    Zhang, Lei

    2013-01-01

    Invited papersIncorporating the multi-cross-sectional temporal effect in Geographically Weighted Logit Regression K. Wu, B. Liu, B. Huang & Z. LeiOne shot learning human actions recognition using key posesW.H. Zou, S.G. Li, Z. Lei & N. DaiBand grouping pansharpening for WorldView-2 satellite images X. LiResearch on GIS based haze trajectory data analysis system Y. Wang, J. Chen, J. Shu & X. WangRegular papersA warning model of systemic financial risks W. Xu & Q. WangResearch on smart mobile phone user experience with grounded theory J.P. Wan & Y.H. ZhuThe software reliability analysis based on

  5. Iron oxide contrast media improve MR-imaging of the portal venous system -an experimental study

    International Nuclear Information System (INIS)

    Boeck, J.C.; Knollmann, F.D.; Teltenkoetter, S.; Wlodarcyk, W.; Muehler, A.; Felix, R.

    1997-01-01

    Purpose: The aim was to demonstrate that intravenous superparamagnetic iron oxide contrast agents improve the delineation of the portal venous system. Material and methods: The portal venous system of 8 minipigs was demonstrated by a FLASH 2-D MRA-sequence. Scans were acquired before and after intravenous administration of 10 and 20 μmol/kg of a superparamagnetic iron oxide contrast agent (SHU 555 A). Signal intensities were measured in the portal vein and hepatic parenchym and contrast-to-noise ratios were calculated. Results: Following a cumulative dose of 10 μmol iron oxide, hepatic parenchymal signal intensity decreased to 67±6%, following 20 μmol to 29±4%, and following 40 μmol to 13±2% of control (p [de

  6. Natural radionuclides and toxic elements in transboundary rivers of Kazakhstan.

    Science.gov (United States)

    Solodukhin, V; Poznyak, V; Kabirova, G; Stepanov, V; Ryazanova, L; Lennik, S; Liventsova, A; Bychenko, A; Zheltov, D

    2015-06-01

    The paper reports on the study of radionuclide and elemental composition of water, bottom sediment and soil samples collected at the border areas of the following transboundary rivers in Kazakhstan: Chagan, Ural, Ilek, Tobol, Ayat, Irtysh, Emel, Ili, Tekes, Shu, Karabalta, Talas and Syrdarya. The employed analyses include the following methods: instrumental gamma-ray spectrometry, radiochemical analysis, neutron activation analysis, XRF and the inductively coupled plasma mass spectrometry (ICP-MS). Evidence of water environment contamination with radionuclides and toxic elements has been revealed in many of the studied rivers both in Kazakhstan and in adjacent countries. Transboundary transfer of the contaminants is most likely related to local industry (uranium mining and processing) and the presence of radioactive substances in the river basins. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  7. Comparison of improved finite-difference WENO schemes for the implicit large eddy simulation of turbulent non-reacting and reacting high-speed shear flows

    International Nuclear Information System (INIS)

    Zhao, S.; Lardjane, N.; Fedioun, I.

    2014-01-01

    Improved WENO schemes, Z, M, and their combination MZ, originally designed to capture sharper discontinuities than the classical fifth order Jiang-Shu scheme does, are evaluated for the purpose of implicit large eddy simulation of free shear flows. 1D Fourier analysis of errors reveals the built-in filter and dissipative properties of the schemes, which are subsequently applied to the canonical Rayleigh-Taylor and Taylor-Green flows. Large eddy simulations of a transonic non-reacting and a supersonic reacting air/H2 jets are then performed at resolution 128 * 128 * 512, showing no significant difference in the flow statistics. However, the computational time varies from one scheme to the other, the Z scheme providing the smaller wall-time due to larger allowed time steps. (authors)

  8. The clinical observation on the treatment of irradiated injuries of the skin and mucosa by using vitamin B12

    International Nuclear Information System (INIS)

    Ji, Hui; Li, Jianchao; Xie, Xiuzhen; Chen, Quiang; Yang, Yongguang

    1987-01-01

    A clinical study of the treatment of irradiated skin and mucosa injuries (40 cases). This paper introduces two methods of treating irradiated injuries of the skin and mucosa. By using Vitamin B 12 both externaly and applying in the mouth, we can stop the pain promptly, reduce the exudation, improve the growth of granulation and the healing of the ulcer especialy in the early acute stage. In addition Vitamin B 12 produces good effects on other kinds of skin injuries. Shu BaiKe considered that the skin had the same function as the liver, which includes various kinds of enzymes. We thought that using Vitamin B 12 externaly on skin injuries, it would be absorbed and join the RNA synthesizing process in the liver and skin. After applying Vitamin B 12 , the RNA content rose. The results of animal experiments coincided with clinial treatment. It clarified the mechanisms needed to treat the third degree acute irradiated skin injuries. (author)

  9. Beneficial Effect of Paljeong-san Pharmacopuncture Treatment Combined with Peritoneal Injection on Glycerol-Induced Acute Renal Failure in Rabbits

    Directory of Open Access Journals (Sweden)

    Chi-Yeon Lim

    2010-09-01

    Full Text Available Purpose: The present study was carried out to determine if Paljeong-san extract (PJS treatment exerts beneficial effect against the glycerol-induced acute renal failure in rabbits. Material and Method: PJS was selected in the basis of invigorating kidney which can eliminate pathogens. Rabbits were treated with PJS pharmacopuncture on Shin-shu (BL23 point for 5 days right after the injection of 50% concentration of glycerol (5㎖/㎏ body weight. Results and Conclusions: Glycerol injection caused an increase in serum creatinine and BUN level and urine glucose secretion, which were accompanied by a reduction in GFR. PJS Pharmacopuncture treatment combined with peritoneal injection showed beneficial effect on glycerol-induced acute renal failure by inhibition of serum creatinine increase and GFR decrease.

  10. Cross-constrained problems for nonlinear Schrodinger equation with harmonic potential

    Directory of Open Access Journals (Sweden)

    Runzhang Xu

    2012-11-01

    Full Text Available This article studies a nonlinear Schodinger equation with harmonic potential by constructing different cross-constrained problems. By comparing the different cross-constrained problems, we derive different sharp criterion and different invariant manifolds that separate the global solutions and blowup solutions. Moreover, we conclude that some manifolds are empty due to the essence of the cross-constrained problems. Besides, we compare the three cross-constrained problems and the three depths of the potential wells. In this way, we explain the gaps in [J. Shu and J. Zhang, Nonlinear Shrodinger equation with harmonic potential, Journal of Mathematical Physics, 47, 063503 (2006], which was pointed out in [R. Xu and Y. Liu, Remarks on nonlinear Schrodinger equation with harmonic potential, Journal of Mathematical Physics, 49, 043512 (2008].

  11. Immune cells: more than simple carriers for systemic delivery of oncolytic viruses

    Directory of Open Access Journals (Sweden)

    Eisenstein S

    2014-11-01

    Full Text Available Samuel Eisenstein,1 Shu-Hsia Chen,2 Ping-Ying Pan21Department of Surgery, 2Department of Oncological Sciences and Tisch Cancer Institute, The Icahn School of Medicine at Mount Sinai, New York, NY, USAAbstract: Oncolytic virotherapy on its own has numerous drawbacks, including an inability of the virus to actively target tumor cells and systemic toxicities at the high doses necessary to effectively treat tumors. Addition of immune cell-based carriers of oncolytic viruses holds promise as a technique in which oncolytic virus can be delivered directly to tumors in smaller and less toxic doses. Interestingly, the cell carriers themselves have also demonstrated antitumor effects, which can be augmented further by tailoring the appropriate oncolytic virus to the appropriate cell type. This review discusses the multiple factors that go into devising an effective, cell-based delivery system for oncolytic viruses.Keywords: oncolytic virus, cell carrier, immune cells, cancer therapy, myeloid-derived suppressor cells

  12. Stalled replication forks generate a distinct mutational signature in yeast

    DEFF Research Database (Denmark)

    Larsen, Nicolai B.; Liberti, Sascha E.; Vogel, Ivan

    2017-01-01

    Proliferating cells acquire genome alterations during the act of DNA replication. This leads to mutation accumulation and somatic cell mosaicism in multicellular organisms, and is also implicated as an underlying cause of aging and tumorigenesis. The molecular mechanisms of DNA replication...... Escherichia coli Tus/Ter complex) engineered into the yeast genome. We demonstrate that transient stalling at this barrier induces a distinct pattern of genome rearrangements in the newly replicated region behind the stalled fork, which primarily consist of localized losses and duplications of DNA sequences....... These genetic alterations arise through the aberrant repair of a single-stranded DNA gap, in a process that is dependent on Exo1- and Shu1-dependent homologous recombination repair (HRR). Furthermore, aberrant processing of HRR intermediates, and elevated HRR-associated mutagenesis, is detectable in a yeast...

  13. Evolution of bioengineering at UCSD: opening new vistas.

    Science.gov (United States)

    Subramaniam, Shankar

    2012-07-01

    Before this, the field of bioengineering refers to biomedical engineering of prosthetic devices in physiology. In addition to exciting applications of engineering principles, UCSD Department of Bioengineering began to extend the notion of engineering models of physiological systems to physiological processes. This led to a conceptual shift in the discipline and contributed to the areas of tissue and physiological process engineering. In 1988, Dr. Shu Chien and Richard Skalak joined UCSD to begin research and education on cellular and molecular bioengineering, especially, mechanobiology. Dr. Fung and Dr. Skalak initiated the new field of tissue engineering. These two decades of evolution of bioengineering and its growth across the country was spearheaded by the Whitaker Foundation, whose leitmotif was the building of bioand biomedical engineering across the country. We have garnered other accomplishments in the following fields: regenerative medicine; bioinspired artificial extracellular matrices; flexible bioelectronics and tatoos; cells show how to synchronize biological clocks; and systems medicine.

  14. Innovate the Teaching of Taiwaness History: An Application of Multimedia Distance Learning—A Web-site Construction Sample of Shih Hsin University

    Directory of Open Access Journals (Sweden)

    Shaw-Fong Lee

    2004-03-01

    Full Text Available Traditionally, the teaching of history course mostly utilizes face to face instruction and oral presentation. Along with the development of educational technology, the teaching methods could be more various such as using internet and multimedia. Literature reviews also indicate that using internet and multimedia may improve the effect of learning and teaching. This paper explores the development of a web-based instructional system for the course of Taiwanese History at Shih Hsin University.The result and the product of this development project is the web site, http://distance.shu.edu.tw/taiwan/list.htm. The content of the web-site includes instructional materials such as animations, videos, pictures, texts, historical maps, and so on. The developmental methods used in this project use curriculum design, survey, interview, review of literatures and focus group discussion.[Article content in Chinese

  15. The role of a creative "joint assignment" project in biomedical engineering bachelor degree education.

    Science.gov (United States)

    Jiehui Jiang; Yuting Zhang; Mi Zhou; Xiaosong Zheng; Zhuangzhi Yan

    2017-07-01

    Biomedical Engineering (BME) bachelor education aims to train qualified engineers who devote themselves to addressing biological and medical problems by integrating the technological, medical and biological knowledge. Design thinking and teamwork with other disciplines are necessary for biomedical engineers. In the current biomedical engineering education system of Shanghai University (SHU), however, such design thinking and teamwork through a practical project is lacking. This paper describes a creative "joint assignment" project in Shanghai University, China, which has provided BME bachelor students a two-year practical experience to work with students from multidisciplinary departments including sociology, mechanics, computer sciences, business and art, etc. To test the feasibility of this project, a twenty-month pilot project has been carried out from May 2015 to December 2016. The results showed that this pilot project obviously enhanced competitive power of BME students in Shanghai University, both in the capabilities of design thinking and teamwork.

  16. Global spiral structure of M81 - radio continuum maps

    International Nuclear Information System (INIS)

    Bash, F.N.; Kaufman, M.; Ohio State Univ., Columbus)

    1986-01-01

    VLA observations of the radio continuum emission from M81 at 6 and 20 cm are presented and used to check the predictions of density-wave theories. Both thermal and nonthermal radiation from the spiral arms are detected. Most of the bright knots along the radio arms are giant radio H II regions. The nonthermal emission defines spiral arms that are patchy and well-resolved, with a width of 1-2 kpc. The observed nonthermal arms are too broad to agree with the continuum gasdynamical calculations of Roberts (1969), Shu et al. (1972), and Visser (1978, 1980) for a classical density wave model. The observed arm widths appear consistent with the predictions of density-wave models that emphasize the clumpy nature of the ISM. The 20 cm arms appear to spiral outward from a faint inner H I ring, suggesting that the ring is produced by the inner Lindblad resonance. 36 references

  17. Actualización en síndrome hemolítico urémico atípico: diagnóstico y tratamiento. Documento de consenso

    Directory of Open Access Journals (Sweden)

    Josep M. Campistol

    2015-09-01

    Full Text Available El síndrome hemolítico urémico (SHU es una entidad clínica definida por la tríada anemia hemolítica no inmune, trombocitopenia e insuficiencia renal aguda, en la que las lesiones subyacentes están mediadas por un proceso de microangiopatía trombótica (MAT sistémico. Distintas causas pueden desencadenar el proceso de MAT que caracteriza el SHU. En este documento consideramos SHU atípico (SHUa como el subtipo de SHU en el que los fenómenos de MAT son fundamentalmente consecuencia del daño producido en el endotelio de la microvasculatura renal y de otros órganos por desregulación de la actividad del sistema del complemento. En los últimos años se han identificado diversas mutaciones en genes del sistema del complemento asociados a SHUa, que explicarían aproximadamente el 60% de los casos de SHUa, y se han caracterizado funcionalmente numerosas mutaciones y polimorfismos asociados a SHUa que han permitido determinar que la patología se produce como consecuencia de la deficiente regulación de la activación del complemento sobre las superficies celulares y que lleva al daño endotelial mediado por la activación del C5 y de la vía terminal del complemento. Eculizumab es un anticuerpo monoclonal humanizado que inhibe la activación del C5, bloqueando la generación de la molécula proinflamatoria C5a y la formación del complejo de ataque de membrana. En estudios prospectivos en pacientes con SHUa su administración ha demostrado la interrupción rápida y sostenida del proceso de MAT, con una mejora significativa de la función renal a largo plazo y una reducción importante de la necesidad de diálisis y el cese de la terapia plasmática. En función de las evidencias científicas publicadas y la experiencia clínica acumulada, el Grupo Español de SHUa publicamos un documento de consenso con recomendaciones para el tratamiento de la enfermedad (Nefrología 2013;33(1:27-45. En la presente versión online del documento se

  18. [Academic heritage of Jiu huang ben cao (Materia Medica for Relief of Famines) in Japan].

    Science.gov (United States)

    He, Huiling; Xiao, Yongzhi

    2014-11-01

    Jiu huang ben cao (Materia Medica for Relief of Famines) was the first monograph on famines herbal in the history of China, which creates a new research field of edible plants. Around the middle and late 17th century, Jiu huang ben cao was spread to Japan and aroused great attention of famous Japanese herbalists. Thus, all versions of different edition systems were circulated in Japan. Later, some famous Japanese scholar ssuccessively quoted texts of Jiu huang ben cao from the Nong zheng quan shu (Whole book on Agricultural Administration) spread in Japan, and block-printed it as an independent work. As a result, Jiu huang ben cao virtually circulated widely in Japan.

  19. Lanthanide metal-organic frameworks

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Peng (ed.) [Nankai Univ., Tianjin (China). Dept. of Chemistry

    2015-03-01

    This book contains the following nine chapters: lanthanide metal-organic frameworks: syntheses, properties, and potential applications (Stephen Fordham, Xuan Wang, Mathieu Bosch, Hong-Cai Zhou); 2. chiral lanthanide metal-organic frameworks (Weisheng Liu, Xiaoliang Tang); 3. Porous lanthanide metal-organic frameworks for gas storage and separation (Bin Li, Banglin Chen); 4. Luminescent lanthanide metal-organic frameworks (Xue-Zhi Song, Shu-Yan Song, Hong-Jie Zhang); 5. Metal-organic frameworks based on lanthanide clusters (Lian Chen, Feilong Jiang, Kang Zhou, Mingyan Wu, Maochun Hong); 6. metal-organic frameworks with d-f cyanide bridges: structural diversity, bonding regime, and magnetism (Marilena Ferbinteanu, Fanica Cimpoesu, Stefania Tanase); 7. transition-lanthanide heterometal-organic frameworks: synthesis, structures, and properties (Wei Shi, Ke Liu, Peng Cheng); 8: MOFs of uranium and the actinides (Juan Su, Jiesheng Chen); 9. Nanostructured and/or nanoscale lanthanide metal-organic frameworks (Zhonghao Zhang, Zhiping Zheng).

  20. Alteração na atividade de peroxidase e concentração de fenóis em microtangerinas (Citrus spp. infectadas por Phytophthora parasitica

    Directory of Open Access Journals (Sweden)

    José Ribamar Gusmão Araújo

    2008-02-01

    Full Text Available The present research aimed to characterize and evaluate species and varieties of small-fruited mandarins of Tanaka’s group (Citrus spp. with potential use as rootstocks, in relation to infection to the Phytophthora parasitica, by means of foliar determination of peroxidase activity and total phenolics content. It was used the following species: C. reshni Hort. ex Tan., C. sunki Hort. ex Tan., C. pectinifera Tan., C. crenatifolia Lush., C. amblycarpa Ochese, C. aurantium L, C. reticulata Blanco and C. limonia Osb. The Center of Citrus Germoplasm of Botucatu and Cordeirópolis provide all plant material. Four resistant varieties to the stem rot and root rot infections: Pectinifera, Crenatifolia, Sun Chu Shu (clone Kat 1004 and Cleopatra (clone 1 were evaluated. Susceptible plants infected by P. parasitica presented higher activity of peroxidase, while phenolics contents were lower in susceptible group.

  1. Investigation on the hematopoietic effect of functional foods using radiation and preparing the provisional product

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sung Ho; Oh, Heon; Lee, Song Eun; Jeong, Yong Woon [Chonnam National University, Kwangju (Korea)

    1999-04-01

    We performed this study to determine the effect of several oriental prescriptions as energy tonic (Chinese medical concept: Bu-Qi) or blood building (Chinese medical concept: Bu-Xie) decoction and its major ingredients on jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells of mice irradiated with high and low dose of gamma-irradiation. For the study of evaluation on the biological stability of irradiated chinese medical prescriptions, we performed the experiment to determine the effect of irradiated (10kGy) or unirradiated Si-Wu-Tang, Bu-Zhong-Yi-Qi-Tang and San-Ling-Bai-Shu-San in irradiated mice. Further studies are needed to characterize better the protective nature of the total extract and its ingredients and for preparing the provisional product. (author). 61 refs., 3 figs., 21 tabs.

  2. Analysis list: NR3C1 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NR3C1 Blood,Bone,Breast,Liver,Others,Prostate,Uterus + hg19 http://dbarchive.biosci...encedbc.jp/kyushu-u/hg19/target/NR3C1.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/NR3C1.5.tsv http:...//dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/NR3C1.10.tsv http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/colo/NR3C1.Blood.tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/NR3C1.Bone.tsv,http:...//dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/NR3C1.Breast.tsv,http://dbarchive.bi

  3. Analysis list: HSF1 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available HSF1 Adipocyte,Blood,Bone,Breast,Digestive tract,Epidermis,Liver + hg19 http://dbar...chive.biosciencedbc.jp/kyushu-u/hg19/target/HSF1.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/HSF1.5.tsv http:...//dbarchive.biosciencedbc.jp/kyushu-u/hg19/target/HSF1.10.tsv http://dbarchive.bioscienced...bc.jp/kyushu-u/hg19/colo/HSF1.Adipocyte.tsv,http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/colo/HSF1.Blood.tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/colo/HSF1.Bone.tsv,http://dba

  4. Analysis list: Chd8 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Chd8 Blood,Embryo + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Chd8.1.tsv http:...//dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Chd8.5.tsv http://dbarchive.biosciencedbc.jp/kyu...shu-u/mm9/target/Chd8.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Chd8.Blood.tsv,http://dbarc...hive.biosciencedbc.jp/kyushu-u/mm9/colo/Chd8.Embryo.tsv http://dbarchive.bioscien...cedbc.jp/kyushu-u/mm9/colo/Blood.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Embryo.gml ...

  5. [Professor DONG Gui-rong's experience for the treatment of peripheral facial paralysis].

    Science.gov (United States)

    Cao, Lian-Ying; Shen, Te-Li; Zhang, Wei; Chen, Si-Hui

    2012-05-01

    Professor DONG Gui-rong's theoretical principle and manipulation points for peripheral facial paralysis were introduced in details from the angels of syndrome differentiation, timing, acupoint prescription and needling methods. For the syndrome differentiation and timing, the professor emphasized to check the treatment timing and follow the symptoms, which should be treated by stages, besides, it was necessary to find and distinguish the reason and nature of diseases to have a combined treatment of tendons and muscles. For the acupoint prescription and needling methods, he has proposed that the acupoints selection should be compatible of distal and lacal, and made a best of Baihui (GV 20) to regulate the whole yang qi, also he has paid much attention to the needling methods and staging treatment. Under the consideration of late stage of peripheral facial paralysis, based on syndrome differentiation Back-shu points have been selected to regulate zang-fu function, should achieve much better therapeutic effect.

  6. Analysis list: Men1 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Men1 Blood,Muscle,Pluripotent stem cell + mm9 http://dbarchive.biosciencedbc.jp/kyu...shu-u/mm9/target/Men1.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Men1.5.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/mm9/target/Men1.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Men1....Blood.tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Men1.Muscle.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/mm9/colo/Men1.Pluripotent_stem_cell.tsv http://dbarchive.bioscienced

  7. Analysis list: Kmt2c [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Kmt2c Embryonic fibroblast,Liver,Muscle + mm9 http://dbarchive.biosciencedbc.jp/kyu...shu-u/mm9/target/Kmt2c.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Kmt2c.5.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/mm9/target/Kmt2c.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Km...t2c.Embryonic_fibroblast.tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/...Kmt2c.Liver.tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Kmt2c.Muscle.tsv http://dbarchive.bioscience

  8. Analysis list: Pbx1 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pbx1 Embryo,Embryonic fibroblast,Muscle + mm9 http://dbarchive.biosciencedbc.jp/kyu...shu-u/mm9/target/Pbx1.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Pbx1.5.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/mm9/target/Pbx1.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Pbx1....Embryo.tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Pbx1.Embryonic_fib...roblast.tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Pbx1.Muscle.tsv http://dbarchive.bioscienced

  9. Analysis list: Hsf1 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Hsf1 Gonad,Neural + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Hsf1....1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Hsf1.5.tsv http://dbarchive.biosciencedbc.jp/kyu...shu-u/mm9/target/Hsf1.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Hsf1.Gonad.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/mm9/colo/Hsf1.Neural.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/mm9/colo/Gonad.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Neural.gml ...

  10. Analysis list: Fli1 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Fli1 Blood,Embryo + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Fli1....1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Fli1.5.tsv http://dbarchive.biosciencedbc.jp/kyu...shu-u/mm9/target/Fli1.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Fli1.Blood.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/mm9/colo/Fli1.Embryo.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/mm9/colo/Blood.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Embryo.gml ...

  11. Analysis list: Tal1 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Tal1 Blood,Embryo,Pluripotent stem cell + mm9 http://dbarchive.biosciencedbc.jp/kyu...shu-u/mm9/target/Tal1.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Tal1.5.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/mm9/target/Tal1.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Tal1....Blood.tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Tal1.Embryo.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/mm9/colo/Tal1.Pluripotent_stem_cell.tsv http://dbarchive.bioscienced

  12. Analysis list: Kdm2 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Kdm2 Adult,Embryo + dm3 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/Kdm2....1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/Kdm2.5.tsv http://dbarchive.biosciencedbc.jp/kyu...shu-u/dm3/target/Kdm2.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Kdm2.Adult.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/Kdm2.Embryo.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/Adult.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Embryo.gml ...

  13. Analysis list: Fosl2 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Fosl2 Blood,Embryo,Embryonic fibroblast + mm9 http://dbarchive.biosciencedbc.jp/kyu...shu-u/mm9/target/Fosl2.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Fosl2.5.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/mm9/target/Fosl2.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Fo...sl2.Blood.tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Fosl2.Embryo.tsv,http://dbarchive.biosci...encedbc.jp/kyushu-u/mm9/colo/Fosl2.Embryonic_fibroblast.tsv http://dbarchive.bioscience

  14. New developments in the theory of spiral galaxies

    International Nuclear Information System (INIS)

    Thielheim, K.O.

    1982-01-01

    About 30% of all galaxies exhibit spiral forms, 60% are elliptical and 10% irregular. It is the objective of galactic dynamics to explain these structural features. A first generation of self-consistent N-body simulations indicates that ellipticals are equilibrium configurations of gravitationally interacting multi-particle systems for which unfortunately a theory does not yet exist. Recent progress has been made on the modal analysis of Freeman disks. In a second generation of N-body simulations spiral density waves have been reproduced in disk configurations. As an alternative to the Lin-Shu conjecture based on the QSSS-hypothesis the author considers a mechanism by which spiral density waves are produced in the surrounding disk as a consequence of the slow increase of the quadrupole moment of a central oval shaped equilibrium configuration immersed in the disk. (Auth.)

  15. Important contributions of M.C. Wang and C.S. Wang Chang to non-equilibrium statistical physics

    International Nuclear Information System (INIS)

    Liu Jixing

    2004-01-01

    In the middle of the 20th century two Chinese women physicists, Ming-Chen Wang and Cheng-Shu Wang Chang made great contributions to statistical physics. The famous review article 'On the theory of the Brownian motion II' by Ming-Chen Wang and G.E. Uhlenbeck published in Rev. of Mod. Phys. in 1945 provided a complete scientific classification of stochastic processes which is still adopted by the scientific community as the standard classification. The Wang-Chang-Uhlenbeck (WCU) equation proposed jointly by C.S. Wang-Chang and Uhlenbeck became the fundamental kinetic equation for the treatment of transport properties of multi-atomic gases with internal degrees of freedom in the physics literature. These important scientific contributions are analyzed and reviewed

  16. Was there a volcanic eruption off Vietnam in AD 608?

    Science.gov (United States)

    Khoo, T. T.

    In the Sui-shu (Annals of the Sui Dynasty, 581-618), there is a record that returning envoys of the Chinese court to a state in northeastern Malay peninsula had in April-June AD 608 reached the state of Lin-i where for a whole day's sail the air around the vessel was yellowish and fetid. Lin-i was located at the southern end of the Annam Highlands chain and it is interpreted here that the phenominon reported could be due to a volcanic eruption in the Poulo Cecir-Ile des Cendres-Veteran volcanic islands group near the area. During the months of May to June the winds of the southwest monsoon, too, blow from the volcanic area toward the southern end of the Annam Highlands.

  17. Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors.

    Science.gov (United States)

    Wessells, H; Hruby, V J; Hackett, J; Han, G; Balse-Srinivasan, P; Vanderah, T W

    2003-01-01

    Penile erection induced by alpha-melanocyte-stimulating hormone and melanocortin receptors (MC-R) in areas of the spinal cord and periphery has not been demonstrated. To elucidate sites of the proerectile action of melanocortin peptides, in awake male rats we administered the MC-R agonist Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH(2) (MT-II) i.c.v., intrathecal (i.th.) and i.v. and scored penile erection and yawning. Injection of the MC-R antagonist Ac-Nle-c[Asp-His-DNal(2')-Arg-Trp-Lys]-NH(2) (SHU-9119) i.c.v. or i.th. in combination with i.th. MT-II differentiated spinal from supraspinal effects. To exclude a site of action in the penis, we recorded intracavernous pressure responses to intracavernosal injection of MT-II in the anesthetized rat.I.c.v., i.th., and i.v. MT-II induced penile erections in a dose-dependent fashion. Yawning was observed with i.c.v. and i.v. MT-II, while spinal injection did not produce this behavior. Intrathecal delivery of MT-II to the lumbosacral spinal cord was more efficacious in inducing erections than i.c.v. or i.v. administration; SHU-9119 blocked the erectile responses to i.th. MT-II when injected i.th. but not i.c.v. Intracavernosal MT-II neither increased intracavernous pressure nor augmented neurostimulated erectile responses. We confirmed the central proerectile activity of MT-II and demonstrated that in addition to a site of action in the brain, the distal spinal cord contains melanocortin receptors that can initiate penile erection independent of higher centers. These results provide new insight into the central melanocortinergic pathways that mediate penile erection and may allow for more efficacious melanotropin-based therapy for erectile dysfunction.

  18. Melanocortin 4 Receptor Activation Attenuates Mitochondrial Dysfunction in Skeletal Muscle of Diabetic Rats.

    Science.gov (United States)

    Zhang, Hao-Hao; Liu, Jiao; Qin, Gui-Jun; Li, Xia-Lian; Du, Pei-Jie; Hao, Xiao; Zhao, Di; Tian, Tian; Wu, Jing; Yun, Meng; Bai, Yan-Hui

    2017-11-01

    A previous study has confirmed that the central melanocortin system was able to mediate skeletal muscle AMP-activated protein kinase (AMPK) activation in mice fed a high-fat diet, while activation of the AMPK signaling pathway significantly induced mitochondrial biogenesis. Our hypothesis was that melanocortin 4 receptor (MC4R) was involved in the development of skeletal muscle injury in diabetic rats. In this study, we treated diabetic rats intracerebroventricularly with MC4R agonist R027-3225 or antagonist SHU9119, respectively. Then, we measured the production of reactive oxygen species (ROS), the levels of malondialdehyde (MDA) and glutathione (GSH), the mitochondrial DNA (mtDNA) content and mitochondrial biogenesis, and the protein levels of p-AMPK, AMPK, peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and manganese superoxide dismutase (MnSOD) in the skeletal muscle of diabetic rats. The results showed that there was significant skeletal muscle injury in the diabetic rats along with serious oxidative stress and decreased mitochondrial biogenesis. Treatment with R027-3225 reduced oxidative stress and induced mitochondrial biogenesis in skeletal muscle, and also activated the AMPK-SIRT1-PGC-1α signaling pathway. However, diabetic rats injected with MC4R antagonist SHU9119 showed an aggravated oxidative stress and mitochondrial dysfunction in skeletal muscle. In conclusion, our results revealed that MC4R activation was able to attenuate oxidative stress and mitochondrial dysfunction in skeletal muscle induced by diabetes partially through activating the AMPK-SIRT1-PGC-1α signaling pathway. J. Cell. Biochem. 118: 4072-4079, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  19. 7A.06: MATERNAL OBESITY AND THE DEVELOPMENTAL PROGRAMMING OF HYPERTENSION: ALTERED LEPTIN SIGNALLING PATHWAY IN THE CENTRAL NERVOUS SYSTEM.

    Science.gov (United States)

    Lim, J; Burke, S; Head, G A

    2015-06-01

    The prevalence of obesity in women among child baring age is increasing and this has been parallel to the increase in obesity in general population around the world. We investigated the trans-generational 'programming' of leptin signalling in the central nervous system (CNS) to increase blood pressure (BP), heart rate (HR) and renal sympathetic nerve activity (RSNA) following a high fat diet (HFD)feeding in mothers. Female New Zealand White rabbits were fed a high fat (13%) diet (mHFD) or a control diet (mCD) prior mating and during pregnancy. Kittens from mCD rabbits were subdivided and fed HFD for 10days (mCD10dHFD) at 15 weeks of age. All rabbits received an intracerebroventricular (ICV) catheter into the lateral ventricle and a recording electrode on the left renal nerve. Experiments were conducted in conscious rabbits and BP, HR and RSNA was measured. Rabbits received an increasing doses of ICV Melanocortin receptor antagonist (SHU9119),alpha-Melanocortin stimulating hormone (alpha-MSH) and a single dose of Leptin antagonist. ICV SHU9119 reduced BP (-5.8 ± 0.7mmHg and -4.1 ± 0.9mmHg) and RSNA (-2.4 ± 0.3 nu and -0.7 ± 0.3 nu) in mHFD and mCD10dHFD rabbits (P fat was increased (50%) in all rabbits that had HFD. Obesity during pregnancy 'programs' leptin signalling pathway in the CNS of the offspring during development. Leptin via activation of melanocirtin pathway plays a key role in the CNS contributing to the pressor and tachycardic effects as well as renal sympathetic nerve activity in the pathophysiology of obesity.

  20. Hydrogeological and multi-isotopic approach to define nitrate pollution and denitrification processes in a coastal aquifer (Sardinia, Italy)

    Science.gov (United States)

    Pittalis, Daniele; Carrey, Raul; Da Pelo, Stefania; Carletti, Alberto; Biddau, Riccardo; Cidu, Rosa; Celico, Fulvio; Soler, Albert; Ghiglieri, Giorgio

    2018-02-01

    Agricultural coastal areas are frequently affected by the superimposition of various processes, with a combination of anthropogenic and natural sources, which degrade groundwater quality. In the coastal multi-aquifer system of Arborea (Italy)—a reclaimed morass area identified as a nitrate vulnerable zone, according to Nitrate Directive 91/676/EEC—intensive agricultural and livestock activities contribute to substantial nitrate contamination. For this reason, the area can be considered a bench test for tuning an appropriate methodology aiming to trace the nitrate contamination in different conditions. An approach combining environmental isotopes, water quality and hydrogeological indicators was therefore used to understand the origins and attenuation mechanisms of nitrate pollution and to define the relationship between contaminant and groundwater flow dynamics through the multi-aquifer characterized by sandy (SHU), alluvial (AHU), and volcanic hydrogeological (VHU) units. Various groundwater chemical pathways were consistent with both different nitrogen sources and groundwater dynamics. Isotope composition suggests a mixed source for nitrate (organic and synthetic fertilizer), especially for the AHU and SHU groundwater. Moreover, marked heterotrophic denitrification and sulfate reduction processes were detected; although, for the contamination related to synthetic fertilizer, the attenuation was inefficient at removing NO3 - to less than the human consumption threshold of 50 mg/L. Various factors contributed to control the distribution of the redox processes, such as the availability of carbon sources (organic fertilizer and the presence of lagoon-deposited aquitards), well depth, and groundwater flow paths. The characterization of these processes supports water-resource management plans, future actions, and regulations, particularly in nitrate vulnerable zones.

  1. Milliken Station Demonstration Project FDG retrofit update

    Energy Technology Data Exchange (ETDEWEB)

    Alder, R.C.; Jackson, C.E.; O`Dea, D.T. [and others

    1994-12-31

    The Milliken Clean Coal Demonstration Project is one of the nine Clean Coal Projects selected for funding in Round 4 of the U.S. DOE`s Clean Coal Demonstration Program. The project`s sponsor is New York State Electric and Gas Corporation (NYSEG). Project team members include CONSOL Inc., Saarberg-Holter-Umwelttechnik (SHU), NALCO/FuelTech, Stebbins Engineering and Manufacturing Co., DHR Technologies, and CE Air Preheater. Gilbert/Commonwealth is the Architect/Engineer and Construction Manager for the flue gas desulfurization (FGD) retrofit. The project will provide full-scale demonstration of a combination of innovative emission-reducing technologies and plant upgraded for the control of sulfur dioxide (SO{sub 2}) and nitrogen oxides (NO{sub x}) emissions from a coal-fired steam generator without a significant loss of station efficiency. The overall project goals are the following: 98% SO{sub 2} removal efficiency using limestone while burning high sulfur coal; up to 70% NO{sub x} reduction using the NOXOUT selective non-catalytic reduction (SNCR) technology in conjunction with combustion modifications; minimization of solid waste by producing marketable by-products including commercial grade gypsum, calcium chloride, and fly ash; zero wastewater discharge; maintenance of station efficiency by using a high efficiency heat-pipe air heater system and a low-power-consuming scrubber system. The demonstration project is being conducted at NYSEG`s Milliken Station, located in Lansing, New York. Milliken Station has two 150-MWe pulverized coal-fired units built in the 1950s by Combustion Engineering. The SHU FGD process and the combustion modifications are being installed on both units, but the NOXOUT process, Plant Economic Optimization Advisor (PEOA), and the high-efficiency air heater system will be installed on only one unit.

  2. Comparative safety testing of genetically modified foods in a 90-day rat feeding study design allowing the distinction between primary and secondary effects of the new genetic event.

    Science.gov (United States)

    Knudsen, Ib; Poulsen, Morten

    2007-10-01

    This article discusses the wider experiences regarding the usefulness of the 90-day rat feeding study for the testing of whole foods from genetically modified (GM) plant based on data from a recent EU-project [Poulsen, M., Schrøder, M., Wilcks, A., Kroghsbo, S., Lindecrona, R.H., Miller, A., Frenzel, T., Danier, J., Rychlik, M., Shu, Q., Emami, K., Taylor, M., Gatehouse, A., Engel, K.-H., Knudsen, I., 2007a. Safety testing of GM-rice expressing PHA-E lectin using a new animal test design. Food Chem. Toxicol. 45, 364-377; Poulsen, M., Kroghsbo, S., Schrøder, M., Wilcks, A., Jacobsen, H., Miller, A., Frenzel, T., Danier, J., Rychlik, M., Shu, Q., Emami, K., Sudhakar, D., Gatehouse, A., Engel, K.-H., Knudsen, I., 2007b. A 90-day safety in Wistar rats fed genetically modified rice expressing snowdrop lectin Galanthus nivalis (GNA). Food Chem. Toxicol. 45, 350-363; Schrøder, M., Poulsen, M., Wilcks, A., Kroghsbo, S., Miller, A., Frenzel, T., Danier, J., Rychlik, M., Emami, K., Gatehouse, A., Shu, Q., Engel, K.-H., Knudsen, I., 2007. A 90-day safety study of genetically modified rice expressing Cry1Ab protein (Bacillus thuringiensis toxin) in Wistar rats. Food Chem. Toxicol. 45, 339-349]. The overall objective of the project has been to develop and validate the scientific methodology necessary for assessing the safety of foods from genetically modified plants in accordance with the present EU regulation. The safety assessment in the project is combining the results of the 90-day rat feeding study on the GM food with and without spiking with the pure novel gene product, with the knowledge about the identity of the genetic change, the compositional data of the GM food, the results from in-vitro/ex-vivo studies as well as the results from the preceding 28-day toxicity study with the novel gene product, before the hazard characterisation is concluded. The results demonstrated the ability of the 90-day rat feeding study to detect the biological/toxicological effects of the

  3. Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors: part 2 modifications at the Phe position.

    Science.gov (United States)

    Holder, Jerry Ryan; Bauzo, Rayna M; Xiang, Zhimin; Haskell-Luevano, Carrie

    2002-07-04

    The melanocortin pathway is an important participant in skin pigmentation, steroidogenesis, obesity, energy homeostasis and exocrine gland function. The centrally located melanocortin-3 and melanocortin-4 receptors (MC3R, MC4R) are involved in the metabolic and food intake aspects of energy homeostasis and are stimulated by melanocortin agonists such as alpha-melanocyte stimulation hormone (alpha-MSH). The melanocortin agonists contain the putative message sequence "His-Phe-Arg-Trp," and it has been well-documented that inversion of chirality of the Phe to DPhe results in a dramatic increase in melanocortin receptor potency. Herein, we report a tetrapeptide library, based upon the template Ac-His-DPhe-Arg-Trp-NH(2), consisting of 26 members that have been modified at the DPhe(7) position (alpha-MSH numbering) and pharmacologically characterized for agonist and antagonist activity at the mouse melanocortin receptors MC1R, MC3R, MC4R, and MC5R. The most notable results of this study include the identification of the tetrapeptide Ac-His-(pI)DPhe-Arg-Trp-NH(2) that is a full nanomolar agonist at the mMC1 and mMC5 receptors, a mMC3R partial agonist with potent antagonist activity (pA(2) = 7.25, K(i) = 56 nM) and, but unexpectedly, is a potent agonist at the mMC4R (EC(50) = 25 nM). This ligand possesses novel melanocortin receptor pharmacology, as compared to previously reported peptides, and is potentially useful for in vivo studies to differentiate MC3R vs MC4R physiological roles in animal models, such as primates, where "knockout" animals are not viable options. The DNal(2') substitution for DPhe resulted in a mMC3R partial agonist with antagonist activity (pA(2) = 6.5, K(i) = 295 nM) and a mMC4R (pA(2) = 7.8, K(i) = 17 nM) antagonist possessing 60- and 425-fold decreased potency, respectively, as compared with SHU9119 at these receptors. Examination of this DNal(2')-containing tetrapeptide at the F254S and F259S mutant mMC4Rs resulted in agonist activity of this m

  4. Effects of melanocortin-4 receptor agonists and antagonists on expression of genes related to reproduction in spotted scat, Scatophagus argus.

    Science.gov (United States)

    Jiang, Dong-Neng; Li, Jian-Tao; Tao, Ya-Xiong; Chen, Hua-Pu; Deng, Si-Ping; Zhu, Chun-Hua; Li, Guang-Li

    2017-05-01

    Melanocortin-4 receptor (Mc4r) function related to reproduction in fish has not been extensively investigated. Here, we report on gene expression changes by real-time PCR following treatment with Mc4r agonists and antagonists in the spotted scat (Scatophagus argus). Using in vitro incubated hypothalamus, the Mc4r nonselective agonist NDP-MSH ([Nle 4 , D-Phe 7 ]-α-melanocyte stimulating hormone; 10 -6 M) and selective agonist THIQ (N-[(3R)-1, 2, 3, 4-Tetrahydroisoquinolinium-3-ylcarbonyl]- (1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-ylmethyl) piperidin-1-yl]-2-oxoethylamine; 10 -7 M) significantly increased the expression of gnrh (Gonadotropin releasing hormone), while the Mc4r nonselective antagonist SHU9119 (Ac-Nle-[Asp-His-DPhe/DNal(2')-Arg-Trp-Lys]-NH2; 10 -6 M) and selective antagonist Ipsen 5i (compound 5i synthesized in Ipsen Research Laboratories; 10 -6 M) significantly inhibited gnrh expression after 3 h of incubation. In incubated pituitary tissue, NDP-MSH and THIQ significantly increased the expression of fshb (Follicle-stimulating hormone beta subunit) and lhb (Luteinizing hormone beta subunit), while SHU9119 and Ipsen 5i significantly decreased fshb and lhb expression after 3 h of incubation. During the in vivo experiment, THIQ (1 mg/kg bw) significantly increased gnrh expression in hypothalamic tissue, as well as the fshb and lhb expression in pituitary tissue 12 h after abdominal injection. Furthermore, Ipsen 5i (1 mg/kg bw) significantly inhibited gnrh expression in hypothalamic tissue, as well as fshb and lhb gene expression in pituitary tissue 12 h after abdominal injection. In summary, Mc4r singling appears to stimulate gnrh expression in the hypothalamus, thereby modulating the synthesis of Fsh and Lh in the pituitary. In addition, Mc4r also appears to directly regulate fshb and lhb levels in the pituitary in spotted scat. Our study suggests that Mc4r, through the hypothalamus and pituitary, participates in reproductive

  5. Obituary: Chi Yuan (1937-2008)

    Science.gov (United States)

    Ho, Paul

    2011-12-01

    Chi Yuan graduated from the National Taiwan University in1959, and received his Masters of Science degree from the University of Florida in 1962, and his Doctor of Philosophy from the University of Michigan in 1966. He was a postdoctoral fellow with Professor C.C. Lin at MIT for three years, before taking his faculty post at the City College of New York in 1969. He attained full professorship at CCNY in 1981. From 1994-1996, Chi returned to Taiwan as Director of the newly found Academia Sinica Institute of Astronomy and Astrophysics (ASIAA). From 1997-2002, he was the recipient of an Outstanding Scholar Award, reserved for the most distinguished scientists employed in Taiwan. Chi retired from ASIAA in 2007, but continued to be active in his research during his two-year fight with brain cancer. Chi Yuan made his greatest impact with his work on the density-wave theory for spiral arm structures in galaxies, with C.C. Lin and Frank Shu. His early work elucidated the observational tests of density-wave theory, and the effects of magnetic fields in galactic shocks. In the 1980s, Chi Yuan worked on spiral density waves in Saturn's rings. In the past two decades, Chi Yuan concentrated on the problem of barred and spiral structures in the nuclei of galaxies, with their implications for fueling the central supermassive black holes. He also worked on the problem of the migration of giant extrasolar planets in their solar disks. These studies were made possible by his establishment of a program on computational fluid dynamics, which became one of the key initiatives in theory at the ASIAA. Among his academic records, two contributions are particularly notable. First, with Typhoon Lee, Fred Lo, and Frank Shu, Chi Yuan founded the ASIAA in order to stimulate the growth of astronomy in Taiwan. Second, and perhaps his greatest influence, has been his training and mentoring of a great number of students in astrophysics, especially for the last 20 years in Taiwan. Today, astronomy

  6. A quantitative comparison of numerical methods for the compressible Euler equations: fifth-order WENO and piecewise-linear Godunov

    International Nuclear Information System (INIS)

    Greenough, J.A.; Rider, W.J.

    2004-01-01

    A numerical study is undertaken comparing a fifth-order version of the weighted essentially non-oscillatory numerical (WENO5) method to a modern piecewise-linear, second-order, version of Godunov's (PLMDE) method for the compressible Euler equations. A series of one-dimensional test problems are examined beginning with classical linear problems and ending with complex shock interactions. The problems considered are: (1) linear advection of a Gaussian pulse in density, (2) Sod's shock tube problem, (3) the 'peak' shock tube problem, (4) a version of the Shu and Osher shock entropy wave interaction and (5) the Woodward and Colella interacting shock wave problem. For each problem and method, run times, density error norms and convergence rates are reported for each method as produced from a common code test-bed. The linear problem exhibits the advertised convergence rate for both methods as well as the expected large disparity in overall error levels; WENO5 has the smaller errors and an enormous advantage in overall efficiency (in accuracy per unit CPU time). For the nonlinear problems with discontinuities, however, we generally see both first-order self-convergence of error as compared to an exact solution, or when an analytic solution is not available, a converged solution generated on an extremely fine grid. The overall comparison of error levels shows some variation from problem to problem. For Sod's shock tube, PLMDE has nearly half the error, while on the peak problem the errors are nearly the same. For the interacting blast wave problem the two methods again produce a similar level of error with a slight edge for the PLMDE. On the other hand, for the Shu-Osher problem, the errors are similar on the coarser grids, but favors WENO by a factor of nearly 1.5 on the finer grids used. In all cases holding mesh resolution constant though, PLMDE is less costly in terms of CPU time by approximately a factor of 6. If the CPU cost is taken as fixed, that is run times are

  7. A mass-conserving multiphase lattice Boltzmann model for simulation of multiphase flows

    Science.gov (United States)

    Niu, Xiao-Dong; Li, You; Ma, Yi-Ren; Chen, Mu-Feng; Li, Xiang; Li, Qiao-Zhong

    2018-01-01

    In this study, a mass-conserving multiphase lattice Boltzmann (LB) model is proposed for simulating the multiphase flows. The proposed model developed in the present study is to improve the model of Shao et al. ["Free-energy-based lattice Boltzmann model for simulation of multiphase flows with density contrast," Phys. Rev. E 89, 033309 (2014)] by introducing a mass correction term in the lattice Boltzmann model for the interface. The model of Shao et al. [(the improved Zheng-Shu-Chew (Z-S-C model)] correctly considers the effect of the local density variation in momentum equation and has an obvious improvement over the Zheng-Shu-Chew (Z-S-C) model ["A lattice Boltzmann model for multiphase flows with large density ratio," J. Comput. Phys. 218(1), 353-371 (2006)] in terms of solution accuracy. However, due to the physical diffusion and numerical dissipation, the total mass of each fluid phase cannot be conserved correctly. To solve this problem, a mass correction term, which is similar to the one proposed by Wang et al. ["A mass-conserved diffuse interface method and its application for incompressible multiphase flows with large density ratio," J. Comput. Phys. 290, 336-351 (2015)], is introduced into the lattice Boltzmann equation for the interface to compensate the mass losses or offset the mass increase. Meanwhile, to implement the wetting boundary condition and the contact angle, a geometric formulation and a local force are incorporated into the present mass-conserving LB model. The proposed model is validated by verifying the Laplace law, simulating both one and two aligned droplets splashing onto a liquid film, droplets standing on an ideal wall, droplets with different wettability splashing onto smooth wax, and bubbles rising under buoyancy. Numerical results show that the proposed model can correctly simulate multiphase flows. It was found that the mass is well-conserved in all cases considered by the model developed in the present study. The developed

  8. Korean Clinic Based Outcome Measure Studies

    Directory of Open Access Journals (Sweden)

    Jongbae Park

    2003-02-01

    Full Text Available Background: Evidence based medicine has become main tools for medical practice. However, conducting a highly ranked in the evidence hierarchy pyramid is not easy or feasible at all times and places. There remains a room for descriptive clinical outcome measure studies with admitting the limit of the intepretation. Aims: Presents three Korean clinic based outcome measure studies with a view to encouraging Korean clinicians to conduct similar studies. Methods: Three studies are presented briefly here including 1 Quality of Life of liver cancer patients after 8 Constitutional acupuncture; 2 Developing a Korean version of Measuring yourself Medical Outcome profile (MYMOP; and 3 Survey on 5 Shu points: a pilot In the first study, we have included 4 primary or secondary liver cancer patients collecting their diagnostic X-ray film and clinical data f개m their hospital, and asked them to fill in the European Organization Research and Treatment of Cancer, Quality of Life Questionnaire before the commencement of the treatment. The acupuncture treatment is set up format but not disclosed yet. The translation and developing a Korean version of outcome measures that is Korean clinician friendly has been sought for MYMOP is one of the most appropriate one. The permission was granted, the translation into Korean was done, then back translated into English only based on the Korean translation by the researcher who is bilingual in both languages. The back translation was compared by the original developer of MYMOP and confirmed usable. In order to test the existence of acupoints and meridians through popular forms of Korean acupuncture regimes, we aim at collecting opinions from 101 Korean clinicians that have used those forms. The questions asked include most effective symptoms, 5 Shu points, points those are least likely to use due to either adverse events or the lack of effectiveness, theoretical reasons for the above proposals, proposing outcome measures

  9. Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists.

    Science.gov (United States)

    Cai, Minying; Marelli, Udaya Kiran; Mertz, Blake; Beck, Johannes G; Opperer, Florian; Rechenmacher, Florian; Kessler, Horst; Hruby, Victor J

    2017-08-15

    Systematic N-methylated derivatives of the melanocortin receptor ligand, SHU9119, lead to multiple binding and functional selectivity toward melanocortin receptors. However, the relationship between N-methylation-induced conformational changes in the peptide backbone and side chains and melanocortin receptor selectivity is still unknown. We conducted comprehensive conformational studies in solution of two selective antagonists of the third isoform of the melanocortin receptor (hMC3R), namely, Ac-Nle-c[Asp-NMe-His 6 -d-Nal(2') 7 -NMe-Arg 8 -Trp 9 -Lys]-NH 2 (15) and Ac-Nle-c[Asp-His 6 -d-Nal(2') 7 -NMe-Arg 8 -NMe-Trp 9 -NMe-Lys]-NH 2 (17). It is known that the pharmacophore (His 6 -DNal 7 -Arg 8 -Trp 9 ) of the SHU-9119 peptides occupies a β II-turn-like region with the turn centered about DNal 7 -Arg 8 . The analogues with hMC3R selectivity showed distinct differences in the spatial arrangement of the Trp 9 side chains. In addition to our NMR studies, we also carried out molecular-level interaction studies of these two peptides at the homology model of hMC3R. Earlier chimeric human melanocortin 3 receptor studies revealed insights regarding the binding and functional sites of hMC3R selectivity. Upon docking of peptides 15 and 17 to the binding pocket of hMC3R, it was revealed that Arg 8 and Trp 9 side chains are involved in a majority of the interactions with the receptor. While Arg 8 forms polar contacts with D154 and D158 of hMC3R, Trp 9 utilizes π-π stacking interactions with F295 and F298, located on the transmembrane domain of hMC3R. It is hypothesized that as the frequency of Trp 9 -hMC3R interactions decrease, antagonistic activity increases. The absence of any interactions of the N-methyl groups with hMC3R suggests that their primary function is to modulate backbone conformations of the ligands.

  10. Weekly nanoparticle albumin bound-paclitaxel in combination with cisplatin versus weekly solvent-based paclitaxel plus cisplatin as first-line therapy in Chinese patients with advanced esophageal squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Wang HY

    2016-09-01

    Full Text Available Hai-ying Wang, Zhi-hua Yao, Hong Tang, Yan Zhao, Xiao-san Zhang, Shu-na Yao, Shu-jun Yang, Yan-yan Liu Department of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, People’s Republic of China Objective: More effective regimens for advanced esophageal squamous cell carcinoma (ESCC are urgently needed. Therefore, a retrospective study concerning the efficacy and safety of nanoparticle albumin-bound paclitaxel plus cisplatin (nab-TP versus solvent-based paclitaxel plus cisplatin (sb-TP as a first-line therapy was conducted in Chinese patients with advanced ESCC.Methods: From June 2009 to June 2015, 32 patients were treated with nab-paclitaxel (125 mg/m2 on the first and eighth days (30 minutes infusion and cisplatin (75 mg/m2 on the second day every 21 days (nab-TP arm. Also, 43 patients were treated with solvent-based paclitaxel (80 mg/m2 intravenously on the first and eighth days and the same dose of cisplatin (sb-TP arm. The two groups were compared in terms of objective response rate (ORR, disease control rate, progression-free survival (PFS, overall survival (OS, and safety profile. OS and PFS were estimated using Kaplan–Meier methods to determine associations between chemotherapy regimens and survival outcomes.Results: Nab-TP demonstrated a higher ORR (50% vs 30%; P=0.082 and disease control rate (81% vs 65%; P=0.124 than sb-TP. Median OS was similar for nab-TP and sb-TP (12.5 vs 10.7 months; P=0.269. However, nab-TP resulted in a longer median PFS (6.1 months [95% confidence interval: 5.3–6.9] than sb-TP (5.0 months [95% confidence interval: 4.4–5.6] (P=0.029. The most common adverse events included anemia, leukopenia, neutropenia, febrile neutropenia, and thrombocytopenia in both the groups and no statistically significant differences were observed between the groups. With statistically significant differences, significantly less grade ≥3 peripheral neuropathy

  11. Characterization and development of EST-derived SSR markers in cultivated sweetpotato (Ipomoea batatas

    Directory of Open Access Journals (Sweden)

    Li Yujun

    2011-10-01

    Full Text Available Abstract Background Currently there exists a limited availability of genetic marker resources in sweetpotato (Ipomoea batatas, which is hindering genetic research in this species. It is necessary to develop more molecular markers for potential use in sweetpotato genetic research. With the newly developed next generation sequencing technology, large amount of transcribed sequences of sweetpotato have been generated and are available for identifying SSR markers by data mining. Results In this study, we investigated 181,615 ESTs for the identification and development of SSR markers. In total, 8,294 SSRs were identified from 7,163 SSR-containing unique ESTs. On an average, one SSR was found per 7.1 kb of EST sequence with tri-nucleotide motifs (42.9% being the most abundant followed by di- (41.2%, tetra- (9.2%, penta- (3.7% and hexa-nucleotide (3.1% repeat types. The top five motifs included AG/CT (26.9%, AAG/CTT (13.5%, AT/TA (10.6%, CCG/CGG (5.8% and AAT/ATT (4.5%. After removing possible duplicate of published EST-SSRs of sweetpotato, a total of non-repeat 7,958 SSR motifs were identified. Based on these SSR-containing sequences, 1,060 pairs of high-quality SSR primers were designed and used for validation of the amplification and assessment of the polymorphism between two parents of one mapping population (E Shu 3 Hao and Guang 2k-30 and eight accessions of cultivated sweetpotatoes. The results showed that 816 primer pairs could yield reproducible and strong amplification products, of which 195 (23.9% and 342 (41.9% primer pairs exhibited polymorphism between E Shu 3 Hao and Guang 2k-30 and among the 8 cultivated sweetpotatoes, respectively. Conclusion This study gives an insight into the frequency, type and distribution of sweetpotato EST-SSRs and demonstrates successful development of EST-SSR markers in cultivated sweetpotato. These EST-SSR markers could enrich the current resource of molecular markers for the sweetpotato community and would

  12. A quantitative comparison of numerical methods for the compressible Euler equations: fifth-order WENO and piecewise-linear Godunov

    Science.gov (United States)

    Greenough, J. A.; Rider, W. J.

    2004-05-01

    A numerical study is undertaken comparing a fifth-order version of the weighted essentially non-oscillatory numerical (WENO5) method to a modern piecewise-linear, second-order, version of Godunov's (PLMDE) method for the compressible Euler equations. A series of one-dimensional test problems are examined beginning with classical linear problems and ending with complex shock interactions. The problems considered are: (1) linear advection of a Gaussian pulse in density, (2) Sod's shock tube problem, (3) the "peak" shock tube problem, (4) a version of the Shu and Osher shock entropy wave interaction and (5) the Woodward and Colella interacting shock wave problem. For each problem and method, run times, density error norms and convergence rates are reported for each method as produced from a common code test-bed. The linear problem exhibits the advertised convergence rate for both methods as well as the expected large disparity in overall error levels; WENO5 has the smaller errors and an enormous advantage in overall efficiency (in accuracy per unit CPU time). For the nonlinear problems with discontinuities, however, we generally see both first-order self-convergence of error as compared to an exact solution, or when an analytic solution is not available, a converged solution generated on an extremely fine grid. The overall comparison of error levels shows some variation from problem to problem. For Sod's shock tube, PLMDE has nearly half the error, while on the peak problem the errors are nearly the same. For the interacting blast wave problem the two methods again produce a similar level of error with a slight edge for the PLMDE. On the other hand, for the Shu-Osher problem, the errors are similar on the coarser grids, but favors WENO by a factor of nearly 1.5 on the finer grids used. In all cases holding mesh resolution constant though, PLMDE is less costly in terms of CPU time by approximately a factor of 6. If the CPU cost is taken as fixed, that is run times are

  13. Variation of hmF2 and NmF2 deduced from DPS-4 over Multan (Pakistan) and their comparisons with IRI-2012 & IRI-2016 during the deep solar minimum between cycles 23 & 24

    Science.gov (United States)

    Ameen, Muhammad Ayyaz; Khursheed, Haqqa; Jabbar, Mehak Abdul; Ali, Muneeza Salman; Chishtie, Farrukh

    2018-04-01

    We report the results of ionospheric measurements from DPS-4 installed at Multan (Geog coord. 30.18°N, 71.48°E, dip 47.4°). The variations in F2-layer maximum electron density NmF2 and its peak height hmF2 are studied during the deep solar minimum between cycles 23 & 24 i.e 2008-2009 with comparisons conducted with the International Reference Ionosphere (IRI) versions 2012 & 2016. We find that the hmF2 observations peak around the pre-sunrise and sunrise hours depending on the month. Seasonally, the daytime variation of NmF2 is higher in the Equinox and Summer, while daytime hmF2 are slightly higher in the Equinox and Winter. High values of hmF2 around midnight are caused by an increase of upward drifts produced by meridional winds. The ionosphere over Multan, which lies at the verge of low and mid latitude, is affected by both E × B drifts and thermospheric winds as evident from mid-night peaks and near-sunrise dips in hmF2. The results of the comparison of the observed NmF2 and hmF2 for the year 2008-2009 with the IRI-2012 (both NmF2 and hmF2) and IRI-2016 (only hmF2) estimates indicate that for NmF2, IRI-2012 with Consultative Committee International Radio (CCIR) option produces values in better agreement with observed data. Whereas, for hmF2, IRI-2016 with both International Union of Radio Science (URSI) and CCIR SHU-2015 options, predicts well for nighttime hours throughout the year. However, the IRI-2012 with CCIR option produces better agreement with data during daytime hours. Furthermore, IRI-2012 with CCIR option gives better results during Equinox months, whereas, IRI-2016 with both URSI and CCIR SHU-2015 options predict well for Winter and Summer.

  14. Sequence Stratigraphic Framework Analysis of Putaohua Oil Reservoir in Chaochang Area of Songliao Basin

    Science.gov (United States)

    Chang, Yan; Liu, Dameng; Yao, Yanbin

    2018-01-01

    The regional structure of the Changchang area in the Songliao Basin is located on the Chaoyangou terrace and Changchunling anticline belt in the central depression of the northern part of the Songliao Basin, across the two secondary tectonic units of the Chaoyanggou terrace and Changchunling anticline. However, with the continuous development of oil and gas, the unused reserves of Fuyu oil reservoir decreased year by year, and the oil field faced a serious shortage of reserve reserves. At the same time, during the evaluation process, a better oil-bearing display was found during the drilling and test oil in the Putao depression to the Chaoyanggou terraces, the Yudong-Taipingchuan area, and in the process of drilling and testing oil in the Putaohua reservoir. Zhao41, Zhao18-1, Shu38 and other exploration wells to obtain oil oil, indicating that the area has a further evaluation of the potential. Based on the principle of stratification, the Putao area was divided into three parts by using the core, logging and logging. It is concluded that the middle and western strata of the study area are well developed, including three sequences, one cycle from bottom to top (three small layers), two cycles (one small layer), three cycles (two small layers) Rhythm is positive-anti-positive. From the Midwest to the southeastern part of the strata, the strata are overtaken, the lower strata are missing, and the top rhythms become rhythmic.

  15. Synthesis and Analysis of MnTiO3 Thin Films on ITO Coated Glass Substrates

    Science.gov (United States)

    Martin, Emerick; Sahiner, Mehmet-Alper

    Perovskites like Manganese Titanium Oxide have interesting chemical properties that may be advantageous to the development of p-n junction photovoltaic cells. Due to the limited understanding behind the compound, it is essential to know the characteristics of it when it is deposited in thin film form. The cells were created using pulsed laser deposition method for two separate mediums (first layers after ITO). ZnO was deposited onto ITO glass for the first sample. For the second sample, a layer of pure Molybdenum was deposited onto the ITO glass. The MnTiO3 was then deposited onto both samples. There was a target thickness of 1000 Angstroms, but ellipsometry shows that, for the Mo based sample, that film thickness was around 1500 Angstroms. There were inconclusive results for the ZnO based sample. The concentration of active carriers was measured using a Hall Effect apparatus for the Mo based sample. The XRD analyses were used to confirm the perovskite structure of the films. Measurements for photoelectric conversion efficiency were taken using a Keathley 2602 ScourceMeter indicated low values for efficiency. The structural information that is correlated with the low electrical performance of this sample will be discussed. SHU-NJSGC Summer 2015 Fellowship.

  16. [Comprehensive textual research on concept, content and function of Chinese yew].

    Science.gov (United States)

    Li, Liangsong; Feng, Zhongke; Liu, Deqing

    2011-06-01

    Chinese yew is a medicinal plant which has the largest planted area, better economic effects and ecological benefits in our country. People have insufficient appreciation of centuries-old historical document and abundant cultural connotation of Chinese yew, because Chinese yew had no name in ancient times and some expressions of western countries are still cited at present. Therefore, this paper did a great deal of analysis and reference works focusing on synonym and byname of ancient Chinese yew. Excavation and classification of historical documents of Chinese yew from ancient classics and bibliography had been done by studying 3 503 books, about billions of words been recorded in the Si Ku Quan Shu. These researches made up for simple and inadequate contents of many large tool books, like Chinese materia medica and traditional Chinese medicine, and so on. At the same time, in order to change the situation of no name, uncertain channel tropism, irregular functions of Chinese yew, its property and flavor, channel tropism, effects and functions had been summarized. History of the tumor treatment of Chinese yew had been traced back to the time of Tang Dynasty and this was almost 1 200 years earlier than western countries.

  17. Effective treatment with icotinib in lung adenocarcinoma with EGFR and ALK co-alterations and brain metastasis

    Directory of Open Access Journals (Sweden)

    Ye CY

    2016-10-01

    Full Text Available Chenyang Ye,1,* Ji Wang,2,* Shu Zheng,1 Ying Chai3 1Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences, The Second Affiliated Hospital, Zhejiang University School of Medicine, 2Department of Surgical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, 3Department of Thoracic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China *These authors contributed equally to this work Abstract: We report a rare case of advanced lung cancer with epidermal growth factor receptor and anaplastic lymphoma kinase co-alterations and brain metastasis, in which icotinib treatment was effective for both the primary lung tumor and the brain metastasis. The patient achieved important clinical remission with a progression-free survival for two years. Our treatment strategy appears to be a promising therapeutic approach for this subgroup of patients. Keywords: lung cancer, brain metastasis, EGFR, ALK, icotinib

  18. Demolition, Documentary and the Politics of Minjian on Contemporary Chinese Screens

    Directory of Open Access Journals (Sweden)

    Dan Edwards

    2017-05-01

    Full Text Available China’s transformation in the reform era has been most immediately experienced by many ordinary citizens in spatial terms, as existing urban communities have been dispersed and their environments levelled, to be replaced by ‘spaces of flows’ that prioritise speed, mobility and circulation. A wide range of Chinese films have represented this experience from the perspective of existing urban communities. This article argues that in certain ‘unofficial’ documentaries produced outside China’s state-sanctioned channels of production and distribution, using small, highly mobile digital video cameras, an engagement with grassroots communities has opened up a new space on screen, in which a critical questioning of the developmental ethos driving contemporary China becomes evident. A close analysis of Ou Ning’s Meishi Street (2006, Shu Haolun’s Nostalgia (2006 and Du Haibin’s A Young Patriot (2015 will illustrate how the unofficial spaces of localised, grassroots cultures (minjian are represented in these works as sites of resistance to the coercive imposition of a globalised modernity on Chinese cities.

  19. Design and development of an intelligent nursing bed - a pilot project of "joint assignment".

    Science.gov (United States)

    Jiehui Jiang; Tingwei Liu; Yuting Zhang; Yu Song; Mi Zhou; Xiaosong Zheng; Zhuangzhi Yan

    2017-07-01

    The "joint assignment" is a creative bachelor education project for Biomedical Engineering (BME) in Shanghai University (SHU), China. The objective of this project is to improve students' capabilities in design thinking and teamwork through practices in the process of the design and development of complex medical product. As the first step, a pilot project "design and development of intelligent nursing bed" was set up in May 2015. This paper describes details of how project organization and management, various teaching methods and scientific evaluation approaches were achieved in this pilot project. For example, a method containing one main line and four branches is taken to manage the project and "prototyping model" was used as the main research approach. As a result a multi-win situation was achieved. The results showed, firstly, 62 bachelor students including 16 BME students were well trained. They improved themselves in use of practical tools, communication skills and scientific writing; Secondly, commercial companies received a nice product design on intelligent nursing bed, and have been working on industrializing it; Thirdly, the university and associated schools obtained an excellent practical education experience to supplement traditional class education; Fourthly and most importantly, requirements from end-users will be met. The results also showed that the "joint assignment" task could become a significant component in BME bachelor education.

  20. Potential and problems in ultrasound-responsive drug delivery systems

    Directory of Open Access Journals (Sweden)

    Zhao YZ

    2013-04-01

    Full Text Available Ying-Zheng Zhao,1,3 Li-Na Du,2 Cui-Tao Lu,1 Yi-Guang Jin,2 Shu-Ping Ge3 1Wenzhou Medical College, Wenzhou City, Zhejiang Province, 2Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, People’s Republic of China; 3St Christopher’s Hospital for Children/Drexel University College of Medicine, Philadelphia, PA, USA Abstract: Ultrasound is an important local stimulus for triggering drug release at the target tissue. Ultrasound-responsive drug delivery systems (URDDS have become an important research focus in targeted therapy. URDDS include many different formulations, such as microbubbles, nanobubbles, nanodroplets, liposomes, emulsions, and micelles. Drugs that can be loaded into URDDS include small molecules, biomacromolecules, and inorganic substances. Fields of clinical application include anticancer therapy, treatment of ischemic myocardium, induction of an immune response, cartilage tissue engineering, transdermal drug delivery, treatment of Huntington’s disease, thrombolysis, and disruption of the blood–brain barrier. This review focuses on recent advances in URDDS, and discusses their formulations, clinical application, and problems, as well as a perspective on their potential use in the future. Keywords: ultrasound, targeted therapy, clinical application

  1. Cuscuta arvensis Beyr "Dodder": In Vivo Hepatoprotective Effects Against Acetaminophen-Induced Hepatotoxicity in Rats.

    Science.gov (United States)

    Koca-Caliskan, Ufuk; Yilmaz, Ismet; Taslidere, Asli; Yalcin, Funda N; Aka, Ceylan; Sekeroglu, Nazim

    2018-05-02

    Cuscuta arvensis Beyr. is a parasitic plant, and commonly known as "dodder" in Europe, in the United States, and "tu si zi shu" in China. It is one of the preferred spices used in sweet and savory dishes. Also, it is used as a folk medicine for the treatment particularly of liver problems, knee pains, and physiological hepatitis, which occur notably in newborns and their mothers in the southeastern part of Turkey. The purpose of this study was to investigate the hepatoprotective effects and antioxidant activities of aqueous and methanolic extracts of C. arvensis Beyr. on acetaminophen (APAP)-induced acute hepatotoxicity in rats. The results were supported by subsequent histopathological studies. The hepatoprotective activity of both the aqueous and methanolic extracts at an oral dose of 125 and 250 mg/kg was investigated by observing the reduction levels or the activity of alkaline phosphatase, alkaline transaminase, aspartate aminotransferase, blood urine nitrogen, and total bilirubin content. In vivo antioxidant activity was determined by analyzing the serum superoxide dismutase, malondialdehyde, glutathione, and catalase levels. Chromatographic methods were used to isolate biologically active compounds from the extract, and spectroscopic methods were used for structure elucidation. Both the methanolic and aqueous extracts exerted noticable hepatoprotective and antioxidant effects supporting the folkloric usage of dodder. One of the bioactive compounds was kaempferol-3-O-rhamnoside, isolated and identified from the methanolic extract.

  2. Development of discrete gas kinetic scheme for simulation of 3D viscous incompressible and compressible flows

    Science.gov (United States)

    Yang, L. M.; Shu, C.; Wang, Y.; Sun, Y.

    2016-08-01

    The sphere function-based gas kinetic scheme (GKS), which was presented by Shu and his coworkers [23] for simulation of inviscid compressible flows, is extended to simulate 3D viscous incompressible and compressible flows in this work. Firstly, we use certain discrete points to represent the spherical surface in the phase velocity space. Then, integrals along the spherical surface for conservation forms of moments, which are needed to recover 3D Navier-Stokes equations, are approximated by integral quadrature. The basic requirement is that these conservation forms of moments can be exactly satisfied by weighted summation of distribution functions at discrete points. It was found that the integral quadrature by eight discrete points on the spherical surface, which forms the D3Q8 discrete velocity model, can exactly match the integral. In this way, the conservative variables and numerical fluxes can be computed by weighted summation of distribution functions at eight discrete points. That is, the application of complicated formulations resultant from integrals can be replaced by a simple solution process. Several numerical examples including laminar flat plate boundary layer, 3D lid-driven cavity flow, steady flow through a 90° bending square duct, transonic flow around DPW-W1 wing and supersonic flow around NACA0012 airfoil are chosen to validate the proposed scheme. Numerical results demonstrate that the present scheme can provide reasonable numerical results for 3D viscous flows.

  3. Structural health monitoring results on Tsing Ma, Kap Shui Mun, and Ting Kau bridges

    Science.gov (United States)

    Wong, Kai-yuen; Chan, Wai-Yee K.; Man, King-Leung; Mak, W. L. N.; Lau, C. K.

    2000-06-01

    A structural health monitoring system has been installed in the cable-supported bridges located in the West of Hong Kong, i.e. the Tsing Ma Control Area. These cable-supported bridges are the Tsing Ma (Suspension) Bridge, the Kap Shu Mun (Cable- Stayed) Bridge and the Ting Kau (Cable-Stayed Bridge) Bridge. The monitoring system of Tsing Ma Bridge and Kap Shui Mun Bridge has been operated since May 1997, whereas the monitoring system of Ting Kau Bridge has been operated since November 1998. In past years, data received from the monitoring systems have been processed, and analyzed and archived. This paper first briefly outlines the operation of the data processing and analysis, and then presents: (1) the load effects monitoring results such as wind, temperature and traffic (highway and railway), and (2) the bridge responses monitoring results such as displacements, stresses/strains, accelerations and cables forces. Comparisons between monitoring results and design parameters and assumptions for the cable-supported bridges are also presented.

  4. Conformational study on cyclic melanocortin ligands and new insight into their binding mode at the MC4 receptor.

    Science.gov (United States)

    Grieco, Paolo; Brancaccio, Diego; Novellino, Ettore; Hruby, Victor J; Carotenuto, Alfonso

    2011-09-01

    The melanocortin receptors are involved in many physiological functions, including pigmentation, sexual function, feeding behavior, and energy homeostasis, making them potential targets to treat obesity, sexual dysfunction, etc. Understanding the basis of the ligand-receptor interactions is crucial for the design of potent and selective ligands for these receptors. The conformational preferences of the cyclic melanocortin ligands MTII (Ac-Nle(4)-c[Asp(5)-His(6)-DPhe(7)-Arg(8)-Trp(9)-Lys(10)]-NH(2)) and SHU9119 (Ac-Nle(4)-c[Asp(5)-His(6)-DNal(2')(7)-Arg(8)-Trp(9)-Lys(10)]-NH(2)), which show agonist and antagonist activity at the h-MC4R, respectively, were comprehensively investigated by solution NMR spectroscopy in different environments. In particular, water and water/DMSO (8:2) solutions were used as isotropic solutions and an aqueous solution of DPC (dodecylphosphocholine) micelles was used as a membrane mimetic environment. NMR-derived conformations of these two ligands were docked within h-MC4R models. NMR and docking studies revealed intriguing differences which can help explain the different activities of these two ligands. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  5. Can Medical Herbs Stimulate Regeneration or Neuroprotection and Treat Neuropathic Pain in Chemotherapy-Induced Peripheral Neuropathy?

    Directory of Open Access Journals (Sweden)

    Sven Schröder

    2013-01-01

    Full Text Available Chemotherapy-induced neuropathy (CIPN has a relevant impact on the quality of life of cancer patients. There are no curative conventional treatments, so further options have to be investigated. We conducted a systematic review in English and Chinese language databases to illuminate the role of medical herbs. 26 relevant studies on 5 single herbs, one extract, one receptor-agonist, and 8 combinations of herbs were identified focusing on the single herbs Acorus calamus rhizoma, Cannabis sativa fructus, Chamomilla matricaria, Ginkgo biloba, Salvia officinalis, Sweet bee venom, Fritillaria cirrhosae bulbus, and the herbal combinations Bu Yang Huan Wu, modified Bu Yang Huan Wu plus Liuwei Di Huang, modified Chai Hu Long Gu Mu Li Wan, Geranii herba plus Aconiti lateralis praeparata radix , Niu Che Sen Qi Wan (Goshajinkigan, Gui Zhi Jia Shu Fu Tang (Keishikajutsubuto, Huang Qi Wu Wu Tang (Ogikeishigomotsuto, and Shao Yao Gan Cao Tang (Shakuyakukanzoto. The knowledge of mechanism of action is still limited, the quality of clinical trials needs further improvement, and studies have not yielded enough evidence to establish a standard practice, but a lot of promising substances have been identified. While CIPN has multiple mechanisms of neuronal degeneration, a combination of herbs or substances might deal with multiple targets for the aim of neuroprotection or neuroregeneration in CIPN.

  6. Bound-Preserving Discontinuous Galerkin Methods for Conservative Phase Space Advection in Curvilinear Coordinates

    Energy Technology Data Exchange (ETDEWEB)

    Mezzacappa, Anthony [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Endeve, Eirik [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hauck, Cory D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Xing, Yulong [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-02-01

    We extend the positivity-preserving method of Zhang & Shu [49] to simulate the advection of neutral particles in phase space using curvilinear coordinates. The ability to utilize these coordinates is important for non-equilibrium transport problems in general relativity and also in science and engineering applications with specific geometries. The method achieves high-order accuracy using Discontinuous Galerkin (DG) discretization of phase space and strong stabilitypreserving, Runge-Kutta (SSP-RK) time integration. Special care in taken to ensure that the method preserves strict bounds for the phase space distribution function f; i.e., f ϵ [0, 1]. The combination of suitable CFL conditions and the use of the high-order limiter proposed in [49] is su cient to ensure positivity of the distribution function. However, to ensure that the distribution function satisfies the upper bound, the discretization must, in addition, preserve the divergencefree property of the phase space ow. Proofs that highlight the necessary conditions are presented for general curvilinear coordinates, and the details of these conditions are worked out for some commonly used coordinate systems (i.e., spherical polar spatial coordinates in spherical symmetry and cylindrical spatial coordinates in axial symmetry, both with spherical momentum coordinates). Results from numerical experiments - including one example in spherical symmetry adopting the Schwarzschild metric - demonstrate that the method achieves high-order accuracy and that the distribution function satisfies the maximum principle.

  7. Experimental Study of Phlebitis Ointment Administration in Acute Superficial Thrombophlebitis

    Directory of Open Access Journals (Sweden)

    Guangzong Li

    2018-01-01

    Full Text Available Acute superficial thrombophlebitis is a venous system disease. Animal models with mannitol induced phlebitis were treated with an orally administered “phlebitis ointment.” 24 rabbits were randomly divided into 4 groups. The therapy group was treated with “phlebitis ointment” and a control group received “Mai Luo Shu Tong granules.” Levels of blood TNF-α, IL-6, CRP, and IL-1β were measured. The tissue expression levels of NF-КBp65 and PKC genes were evaluated. The therapy group showed a better improvement of the clinical status and similar vascular morphology than the control group. A blank group showed no vascular changes through pathological investigation. In contrast, significant vascular changes were seen in the model group. The control group showed slight vascular modifications. Small thrombi could be found in the lumen despite the intact tunica intima. Both control and therapy group showed less inflammatory cells infiltration than the model group and upregulation of NF-КBp65 and PKC genes. The phlebitis ointment reduced the levels of necrosis factor-α, interleukin-6, C-reactive protein, and interleukin-1ß. The expressions of NF-КBp65 and PKC genes, which are the primary mechanisms underlying the development of thrombophlebitis, were improved significantly in tissues of both therapy group and control group.

  8. Acupuncture for serum uric acid in patients with asymptomatic hyperuricemia: A randomized, double-blind, placebo-controlled trial.

    Science.gov (United States)

    Huang, Yingjuan; Meng, Jun; Sun, Baoguo; Xiang, Ting; Zhou, Xin; Xu, Biyu; Wu, Yingzi; Chen, Zexiong; Zhang, Shijun

    2017-04-01

    Hyperuricemia (HUA) is the most common disease associated with cardiovascular disease, metabolic syndrome, hypertension, and kidney disease. The objective of the current study was to evaluate the preliminary efficacy, mechanism, and safety of acupuncture on serum uric acid in patients with asymptomatic HUA. A randomized, placebo-controlled trial among 123 patients with asymptomatic HUA was conducted. The acupoints used in the acupuncture group were bilateral Five Shu in Spleen Meridian. Each participant received the intervention once daily for 10 consecutive days. The sham group received the same treatment duration on the same acupoints by the Park Sham Device. All patients underwent measurements of serum or urine creatinine, uric acid, serum lipid profiles, fasting plasma glucose, HbA1c, xanthine oxidase (XOD) and urate-anion exchanger (URAT-1). At the end of the intervention, the individuals in the acupuncture group were found to have significantly less levels of serum uric acid than those in the sham group [(453±65 vs. 528±81) μmol/L, puric acid level, urine pH value and 24-hour urine volume than the sham treatment (puric acid in a Chinese HUA patient population. The mechanism might be associated with the decrease level of enzyme URAT-1. ChiCTR-TRC-13004122. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Application of capability indices and control charts in the analytical method control strategy.

    Science.gov (United States)

    Oliva, Alexis; Llabres Martinez, Matías

    2017-08-01

    In this study, we assessed the usefulness of control charts in combination with the process capability indices, C pm and C pk , in the control strategy of an analytical method. The traditional X-chart and moving range chart were used to monitor the analytical method over a 2-year period. The results confirmed that the analytical method is in-control and stable. Different criteria were used to establish the specifications limits (i.e. analyst requirements) for fixed method performance (i.e. method requirements). If the specification limits and control limits are equal in breadth, the method can be considered "capable" (C pm  = 1), but it does not satisfy the minimum method capability requirements proposed by Pearn and Shu (2003). Similar results were obtained using the C pk index. The method capability was also assessed as a function of method performance for fixed analyst requirements. The results indicate that the method does not meet the requirements of the analytical target approach. A real-example data of a SEC with light-scattering detection method was used as a model whereas previously published data were used to illustrate the applicability of the proposed approach. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Melanocortin-4 receptor activation stimulates hypothalamic brain-derived neurotrophic factor release to regulate food intake, body temperature and cardiovascular function.

    Science.gov (United States)

    Nicholson, J R; Peter, J-C; Lecourt, A-C; Barde, Y-A; Hofbauer, K G

    2007-12-01

    In the present study, we aimed to investigate the neuromodulatory role played by hypothalamic brain-derived neurotrophic factor (BDNF) in the regulation of acute cardiovascular and feeding responses to melanocortin-4 receptor (MC4R) activation. In vitro, a selective MC4R agonist, MK1, stimulated BDNF release from isolated rat hypothalami and this effect was blocked by preincubation with the MC3/4R antagonist SHU-9119. In vivo, peripheral administration of MK1 decreased food intake in rats and this effect was blocked by pretreatment with an anti-BDNF antibody administered into the third ventricle. When anorexia was induced with the cannabinoid-1 receptor (CB1R) antagonist AM251, the anti-BDNF antibody did not prevent the reduction in food intake. Peripheral administration of MK1 also increased mean arterial pressure, heart rate and body temperature. These effects were prevented by pretreatment with the anti-BDNF antibody whereas the intracerebroventricular administration of BDNF caused changes similar to those of MK1. These findings demonstrate for the first time that activation of MC4R leads to an acute release of BDNF in the hypothalamus. This release is a prerequisite for MC4R-induced effects on appetite, body temperature and cardiovascular function. By contrast, CB1R antagonist-mediated anorexia is independent of the MC4R/BDNF pathway. Overall, these results show that BDNF is an important downstream mediator of the MC4R pathway.

  11. [Nomenclature of Feiyang (BL 58) and its connotation exploration based on A-B Classic of Acupuncture and Moxibustion].

    Science.gov (United States)

    Feng, Shuangshuang; Hou, Zhongwei

    2018-04-12

    A - B Classic of Acupuncture and Moxibustion ( Zhen Jiu Jia Yi Jing ) is the earliest and existed well-known work on acupuncture and moxibustion, with irreplaceable literature values and huge impacts on the later generations. Feiyang (BL 58) is the luo -connecting point of the bladder meridian and recorded 11 times in A - B Classic of Acupuncture and Moxibustion . This book is the representative for the exploration on the acupoint nomenclature and clinical connotation. Through the investigation on the textual connotation of the specified terms and the alias of Feiyang (BL 58), it was discovered that the nomenclature of this acupoint was based on the main symptoms, the characters of the running course of meridian and acupuncture effects. It was proved that the unique property of this acupoint was as rising, dispersing and flying of meridian qi . In comparison of Huangdi Three - Version of A - B Classic of Acupuncture and Moxibustion ( Huangdi Sanbu Zhen Jiu Jia Yi Jing ) of the printed edition of the Song Dynasty version and Meridian - Collateral and Acupoints ( Zhen Jiu Shu Xue Xue ), it was found that the indications and connotation of Feiyang (BL 58) were more extensively richer than the records in teaching materials. Those study results contribute to the extension of the clinical application of this acupoint.

  12. Orbital apex cyst: a rare cause of compressive optic neuropathy post-functional endoscopic sinus surgery

    Directory of Open Access Journals (Sweden)

    Koh YN

    2017-07-01

    Full Text Available Yi Ni Koh,1,2 Shu Fen Ho,2 Letchumanan Pathma,3 Harvinder Singh,3 Embong Zunaina1 1Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia; 2Department of Ophthalmology, 3Department of Otorhinolaryngology, Hospital Raja Permaisuri Bainun, Ipoh, Perak, Malaysia Abstract: There are various causes that can lead to compressive optic neuropathy. We present here orbital apex cyst as an unusual cause of compressive optic neuropathy in a 49-year-old male. He presented with 2 weeks painless loss of vision in the left eye with left-sided headache. He had had left functional endoscopic sinus surgery for left nasal polyps 4 years earlier. Magnetic resonance imaging of brain and orbit revealed a left discrete orbital nodule, possibly orbital cyst or mucocele, which was compressing on the left optic nerve. Left eye vision improved markedly from hand movement to 6/36 pinhole 6/18 after initiation of intravenous dexamethasone. A subsequent endoscopic endonasal left optic nerve decompression found the orbital nodule lesion to be an orbital cyst. Marsupialization was performed instead of excision, as the cyst ruptured intraoperatively. Postoperative vision improved to 6/7.5 with normal optic nerve function postoperatively. Possible cause of orbital apex cyst is discussed. Keywords: orbital cyst, compressive optic neuropathy, functional endoscopic sinus surgery

  13. Identification of the Chemical Constituents in Aqueous Extract of Zhi-Qiao and Evaluation of Its Antidepressant Effect

    Directory of Open Access Journals (Sweden)

    Ming Wu

    2015-04-01

    Full Text Available The immature fruit of Citrus aurantium L. (Zhi-Qiao, ZQ has been used as a traditional medicine in China. Our previous study has shown that ZQ decoction may contribute to the antidepressant-like action of Chaihu-Shu-Gan-San. However, there are no reports on the chemical constituents of ZQ aqueous extract or its anti-depression effects. Firstly, this research reported the on-line identification of the chemical constituents in the aqueous extract of ZQ by coupling ultra-performance liquid chromatography/time-of-flight mass spectrometry (UPLC-Q-TOF/MS. A total of 31 chemical constituents were identified in ZQ aqueous extract, including one tannic acid, five flavones, 13 flavanones, one limonoid, three coumarins, three cyclic peptides, and five polymethoxylated flavonoids. The antidepressant effect of ZQ aqueous extract was evaluated in vivo and the results indicated that the mice immobility time during the forced swimming test and the tail suspension test were significantly reduced with ZQ treatment. MTT assays showed both ZQ aqueous extract and its major constituents (naringin, hesperidin, neohesperidin, and nobiletin had neuroprotective effect on corticosterone-induced neurotoxicity in PC12 cells. The in vivo and in vitro results suggest that ZQ has an antidepressant effect.

  14. [The affinity between Le family of Tong Ren Tang and acu-moxibustion as viewed from Mian xue tang zhen jiu ji cheng (Mian Xuetang's Synthetic Work of Acu-moxibustion)].

    Science.gov (United States)

    Huang, L X

    2017-11-28

    This compilation process of Mian xue tang zhen jiu ji cheng ( Mian Xuetang ' s Synthetic Work of Acu - moxibustion )was quite mysterious, the book's advent coincidentally met with several major historical events which made its value of decoding its historical functions far beyond its academic value. The editor of this book is Le Xianyang, the founder of Tong Ren Tang. While compiling this book, he also made a replica of Ming-Dynasty's Zhengtong bronze statue. More than 200 years later, Le Jingyu, the 12th generation of the Le family revised Ming Tang Tu inherited from his ancestors and engraved Ming Tang Tu on the stone for its standardization. This great achievement of Le family was no less than the recasting of the Tiansheng bronze statue and the reengraving Tong ren shu xue zhen jiu tu jing ( Illustrated Manual of Acupuncture Points of the Bronze Figure ) by support of state power for building the Beijing Imperial Hospital in the eighth year of the Zhengtong reign (1443).

  15. The interrelation of circulation processes in the atmosphere by B. L. Dzerdzeyevskiy with the change of runoff in the basins of rivers of South Kazakhstan

    Science.gov (United States)

    Tursunova, Aisulu

    2017-05-01

    The article contains analysis of the interrelation of circulation processes in the atmosphere with the change of runoff in the basins of rivers. The results of estimates which show the relationship of circulation processes in the atmosphere with the runoff of the zone of formation of one of southern regions of Kazakhstan are discussed. The typification of circulation processes by B. L. Dzerdzeyevskiy and previously made estimates of water resources in the basins of rivers of South Kazakhstan were assumed as a basis. Certain areas were considered in this work: the Ile-Balkash basin, basin of rivers Shu-Talas and basin of the Syrdariya river, each basin is considered separately, since the runoff varies by regions and by the value of fluctuations, it is not permanent, because of the various factors of runoff formation in individual basins of that region. The calculations performed have shown the possibility of using typification of elementary circulation mechanism (ECM) for further researches of climatic changes, including to determine the direction of change of river runoff in other river basins. The created database on annual values of each of the 41 types of ECM can be used in other studies as well.

  16. [Theoretical origin and clinical application of wrist-ankle acupuncture therapy].

    Science.gov (United States)

    Wang, Qiong; Zhou, Qinghui

    2017-05-12

    The theory of wrist-ankle acupuncture is consistent with traditional meridian-collateral theory. For example, the body divisions of wrist-ankle acupuncture are corresponding to the distribution of 12 cutaneous regions of meridians, the needling sites of it are to the running courses of 12 meridians; the indications of it are to those of 12 meridians. The needling sites of wrist-ankle acupuncture are relevant with some special acupoints of acupuncture theory. For example, the 12-needling sites of wrist-ankle acupuncture are located similar to those of 12 meridian points and have very similar indications. The needling sites of it are located in the wrist and ankle regions, in which the five- shu points are located nearby, for meridian disorders. Most luo -connecting points are located near to the needling sites of wrist-ankle acupuncture or the needle tip points to. Additionally, the needling method of wrist-ankle acupuncture is consistent with some of the subcutaneous needling methods in traditional acupuncture therapy. On the basis of the aspects mentioned above, it is explained that wrist-ankle acupuncture is the development of traditional acupuncture and cannot be independent from the traditional theories of acupuncture and meridians. It is necessary to seek for the evidence from the traditional theories of TCM. The traditional theories of TCM are summarized from clinical practice, which can be newly verified from the practice of wrist-ankle acupuncture.

  17. Assessment of high-resolution methods for numerical simulations of compressible turbulence with shock waves

    International Nuclear Information System (INIS)

    Johnsen, Eric; Larsson, Johan; Bhagatwala, Ankit V.; Cabot, William H.; Moin, Parviz; Olson, Britton J.; Rawat, Pradeep S.; Shankar, Santhosh K.; Sjoegreen, Bjoern; Yee, H.C.; Zhong Xiaolin; Lele, Sanjiva K.

    2010-01-01

    Flows in which shock waves and turbulence are present and interact dynamically occur in a wide range of applications, including inertial confinement fusion, supernovae explosion, and scramjet propulsion. Accurate simulations of such problems are challenging because of the contradictory requirements of numerical methods used to simulate turbulence, which must minimize any numerical dissipation that would otherwise overwhelm the small scales, and shock-capturing schemes, which introduce numerical dissipation to stabilize the solution. The objective of the present work is to evaluate the performance of several numerical methods capable of simultaneously handling turbulence and shock waves. A comprehensive range of high-resolution methods (WENO, hybrid WENO/central difference, artificial diffusivity, adaptive characteristic-based filter, and shock fitting) and suite of test cases (Taylor-Green vortex, Shu-Osher problem, shock-vorticity/entropy wave interaction, Noh problem, compressible isotropic turbulence) relevant to problems with shocks and turbulence are considered. The results indicate that the WENO methods provide sharp shock profiles, but overwhelm the physical dissipation. The hybrid method is minimally dissipative and leads to sharp shocks and well-resolved broadband turbulence, but relies on an appropriate shock sensor. Artificial diffusivity methods in which the artificial bulk viscosity is based on the magnitude of the strain-rate tensor resolve vortical structures well but damp dilatational modes in compressible turbulence; dilatation-based artificial bulk viscosity methods significantly improve this behavior. For well-defined shocks, the shock fitting approach yields good results.

  18. An Introduction to Plum Blossom Boxing: History, Culture and Practice

    Directory of Open Access Journals (Sweden)

    Guodong Zhang

    2012-07-01

    Full Text Available Meihuaquan (“Plum Blossom Fist [Boxing]” has traditionally been practiced as vernacular (folk art practiced among the Han ethnic group residing in the Shandong, Henan and Hebei Provinces of China. Historical documentation dates Plum Blossom Boxing to the seventeenth century. The classic Chinese novel, Shuǐhǔ Zhuàn (Marsh Chronicles recounts the martial exploits of Shandong’s twelfth century outlaw heroes who may have been Mei Boxers, also. Thus, for perhaps a millennium, the region has been noted for vernacular martial arts and social banditry. The region’s rampant lawlessness promoted highly-developed martial prowess among both lawbreakers and those who were required to protect themselves against the brigands. Cultural, economic, and environmental factors in the region gave rise to heterodox political and religious beliefs that frequently served as a catalyst for martial sects, most notably the “Boxers” who at the turn of the twentieth century, came into conflict with the imperial government. These factors laid the groundwork for the “character traits” of the art while Taoism, the Five Elements theory, and a concept of predictable change shaped Plum Boxing’s strategic and mechanical principles. In the past decade, there have been efforts to globalize this vernacular martial art. Rather than driving Plum Boxing to extinction it is likely that the folk and the “larger than local” will co-exist.

  19. Comprehensive cognitive and cerebral hemodynamic evaluation after cranioplasty

    Directory of Open Access Journals (Sweden)

    Coelho F

    2014-05-01

    Full Text Available Fernanda Coelho,1 Arthur Maynart Oliveira,2 Wellingson Silva Paiva,2 Fabio Rios Freire,1 Vanessa Tome Calado,1 Robson Luis Amorim,2 Iuri Santana Neville,2 Almir Ferreira de Andrade,2 Edson Bor-Seng-Shu,3 Renato Anghinah,1 Manoel Jacobsen Teixeira21Neurorehabilitation Group, Division of Neurology, 2Division of Neurosurgery, 3Neurosonology and Cerebral Hemodynamics Group, University of São Paulo Medical School, São Paulo, BrazilAbstract: Decompressive craniectomy is an established procedure to lower intracranial pressure and can save patients' lives. However, this procedure is associated with delayed cognitive decline and cerebral hemodynamics complications. Studies show the benefits of cranioplasty beyond cosmetic aspects, including brain protection, and functional and cerebrovascular aspects, but a detailed description of the concrete changes following this procedure are lacking. In this paper, the authors report a patient with trephine syndrome who underwent cranioplasty; comprehensive cognitive and cerebral hemodynamic evaluations were performed prior to and following the cranioplasty. The discussion was based on a critical literature review.Keywords: cranioplasty, decompressive craniotomy, perfusion CT, traumatic brain injury, cognition, neuropsychological test

  20. Late-maturing cooking rice Sensyuraku has excellent properties, equivalent to sake rice, for high-quality sake brewing.

    Science.gov (United States)

    Anzawa, Yoshihiko; Satoh, Kenji; Satoh, Yuko; Ohno, Satomi; Watanabe, Tsutomu; Katsumata, Kazuaki; Kume, Kazunori; Watanabe, Ken-Ichi; Mizunuma, Masaki; Hirata, Dai

    2014-01-01

    Low protein content and sufficient grain rigidity are desired properties for the rice used in high-quality sake brewing such as Daiginjo-shu (polishing ratio of the rice, less than 50%). Two kinds of rice, sake rice (SR) and cooking rice (CR), have been used for sake brewing. Compared with those of SR, analyses of CR for high-quality sake brewing using highly polished rice have been limited. Here we described the original screening of late-maturing CR Sensyuraku (SEN) as rice with low protein content and characterization of its properties for high-quality sake brewing. The protein content of SEN was lower than those of SR Gohyakumangoku (GOM) and CR Yukinosei (YUK), and its grain rigidity was higher than that of GOM. The excellent properties of SEN with respect to both water-adsorption and enzyme digestibility were confirmed using a Rapid Visco Analyzer (RVA). Further, we confirmed a clear taste of sake produced from SEN by sensory evaluation. Thus, SEN has excellent properties, equivalent to those of SR, for high-quality sake brewing.

  1. Phytochemistry, pharmacology, and clinical trials of Morus alba.

    Science.gov (United States)

    Chan, Eric Wei-Chiang; Lye, Phui-Yan; Wong, Siu-Kuin

    2016-01-01

    The present review is aimed at providing a comprehensive summary on the botany, utility, phytochemistry, pharmacology, and clinical trials of Morus alba (mulberry or sang shu). The mulberry foliage has remained the primary food for silkworms for centuries. Its leaves have also been used as animal feed for livestock and its fruits have been made into a variety of food products. With flavonoids as major constituents, mulberry leaves possess various biological activities, including antioxidant, antimicrobial, skin-whitening, cytotoxic, anti-diabetic, glucosidase inhibition, anti-hyperlipidemic, anti-atherosclerotic, anti-obesity, cardioprotective, and cognitive enhancement activities. Rich in anthocyanins and alkaloids, mulberry fruits have pharmacological properties, such as antioxidant, anti-diabetic, anti-atherosclerotic, anti-obesity, and hepatoprotective activities. The root bark of mulberry, containing flavonoids, alkaloids and stilbenoids, has antimicrobial, skin-whitening, cytotoxic, anti-inflammatory, and anti-hyperlipidemic properties. Other pharmacological properties of M. alba include anti-platelet, anxiolytic, anti-asthmatic, anthelmintic, antidepressant, cardioprotective, and immunomodulatory activities. Clinical trials on the efficiency of M. alba extracts in reducing blood glucose and cholesterol levels and enhancing cognitive ability have been conducted. The phytochemistry and pharmacology of the different parts of the mulberry tree confer its traditional and current uses as fodder, food, cosmetics, and medicine. Overall, M. alba is a multi-functional plant with promising medicinal properties. Copyright © 2016 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

  2. [STUDYING THE ROLE OF BRAIN MELANOCORTIN RECEPTORS IN THE SUPPRESSING OF FOOD INTAKE UNDER ETHER STRESS IN MICE].

    Science.gov (United States)

    Bazhan, N M; Kulikova, E V; Makarova, E N; Yakovleva, T V; Kazantseva, A Yu

    2015-12-01

    Melanocortin (MC) system regulates food intake under the rest conditions. Stress inhibits food intake. It is not clear whether brain MC system is involved in stress-induced anorexia in mice. The aim of the work was to investigate the effect of pharmacological blockade and activation of brain MC receptors on food intake under stress. C57B1/6J male mice were subjected to ether stress (0.5 minute ether anesthesia) before the administration of saline solution or synthetic non-selective blocker (SHU9119) or agonist (Melanotan II) of MC receptors into the lateral brain ventricle. Food intake was pre-stimulated with 17 hours of fasting in all mice. Ether stress decreased food intake, increased the plasma corticosterone level and hypothalamic mRNA AgRP (natural MC receptor antagonist) level at 1 hour after the stress. Pharmacological blockade of the MC receptors weakened stress-induced anorexia and decreased mRNA AgRP level in the hypothalamus. Pharmacological stimulation of the MC receptors enhanced ether stress-induced anorexia and hypercortisolism. Thus, our data demonstrated that the central MC system was involved in the development of stress-induced anorexia in mice.

  3. Remote Sensing Open Access Journal: Leading a New Paradigm in Publishing

    Directory of Open Access Journals (Sweden)

    Prasad S. Thenkabail

    2011-12-01

    Full Text Available Remote Sensing is a pathfinding open access journal providing great opportunities for the growing community of remote sensing and geoscience scientists and practitioners to publish high quality research and practical papers expeditiously. It is a journal keeping up with the changing times we live in: open access, instant access, free access, and global access from whichever precise latitude and longitude you live in on the planet Earth or for that matter anywhere in space as long as we have internet access! So, open access journals are breaking many paradigms and setting forth new ones that will soon become the norm as we advance into the twenty-first century. The days of inordinate delays in publishing good science research articles are fast disappearing with open access journals. In remote sensing and geoscience, Remote Sensing (http://www.mdpi.com/journal/remotesensing/ is one of the pioneers, thanks to the vision of Dr. Shu-Kun Lin, the publisher. It started in the year 2009 with headquarters in Basel, Switzerland and a branch office in Beijing, China. It will soon complete Volume 3 by the end of 2011.

  4. Special boundedness properties in numerical initial value problems

    KAUST Repository

    Hundsdorfer, W.

    2011-09-21

    For Runge-Kutta methods, linear multistep methods and other classes of general linear methods much attention has been paid in the literature to important nonlinear stability properties known as total-variation-diminishing (TVD), strong stability preserving (SSP) and monotonicity. Stepsize conditions guaranteeing these properties were studied by Shu and Osher (J. Comput. Phys. 77:439-471, 1988) and in numerous subsequent papers. Unfortunately, for many useful methods it has turned out that these properties do not hold. For this reason attention has been paid in the recent literature to the related and more general properties called total-variation-bounded (TVB) and boundedness. In the present paper we focus on stepsize conditions guaranteeing boundedness properties of a special type. These boundedness properties are optimal, and distinguish themselves also from earlier boundedness results by being relevant to sublinear functionals, discrete maximum principles and preservation of nonnegativity. Moreover, the corresponding stepsize conditions are more easily verified in practical situations than the conditions for general boundedness given thus far in the literature. The theoretical results are illustrated by application to the two-step Adams-Bashforth method and a class of two-stage multistep methods. © 2011 Springer Science + Business Media B.V.

  5. STAR FORMATION IN DENSE CLUSTERS

    International Nuclear Information System (INIS)

    Myers, Philip C.

    2011-01-01

    A model of core-clump accretion with equally likely stopping describes star formation in the dense parts of clusters, where models of isolated collapsing cores may not apply. Each core accretes at a constant rate onto its protostar, while the surrounding clump gas accretes as a power of protostar mass. Short accretion flows resemble Shu accretion and make low-mass stars. Long flows resemble reduced Bondi accretion and make massive stars. Accretion stops due to environmental processes of dynamical ejection, gravitational competition, and gas dispersal by stellar feedback, independent of initial core structure. The model matches the field star initial mass function (IMF) from 0.01 to more than 10 solar masses. The core accretion rate and the mean accretion duration set the peak of the IMF, independent of the local Jeans mass. Massive protostars require the longest accretion durations, up to 0.5 Myr. The maximum protostar luminosity in a cluster indicates the mass and age of its oldest protostar. The distribution of protostar luminosities matches those in active star-forming regions if protostars have a constant birthrate but not if their births are coeval. For constant birthrate, the ratio of young stellar objects to protostars indicates the star-forming age of a cluster, typically ∼1 Myr. The protostar accretion luminosity is typically less than its steady spherical value by a factor of ∼2, consistent with models of episodic disk accretion.

  6. Monitoring cancer stem cells: insights into clinical oncology

    Directory of Open Access Journals (Sweden)

    Lin SC

    2016-02-01

    Full Text Available ShuChen Lin,1,* YingChun Xu,2,* ZhiHua Gan,1 Kun Han,1 HaiYan Hu,3 Yang Yao,3 MingZhu Huang,4 DaLiu Min1 1Department of Oncology, Shanghai Sixth People’s Hospital East Campus, Shanghai Jiao Tong University, 2Department of Oncology, Renji Hospital, Shanghai Jiao Tong University, 3Department of Oncology, The Sixth People’s Hospital, Shanghai Jiao Tong University, 4Department of Medical Oncology, Cancer Hospital of Fudan University, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: Cancer stem cells (CSCs are a small, characteristically distinctive subset of tumor cells responsible for tumor initiation and progression. Several treatment modalities, such as surgery, glycolytic inhibition, driving CSC proliferation, immunotherapy, and hypofractionated radiotherapy, may have the potential to eradicate CSCs. We propose that monitoring CSCs is important in clinical oncology as CSC populations may reflect true treatment response and assist with managing treatment strategies, such as defining optimal chemotherapy cycles, permitting pretreatment cancer surveillance, conducting a comprehensive treatment plan, modifying radiation treatment, and deploying rechallenge chemotherapy. Then, we describe methods for monitoring CSCs. Keywords: cancer stem cells, glycolytic inhibition, watchful waiting, rechallenge, immunotherapy

  7. Preconditioning methods to improve SAGD performance in heavy oil and bitumen reservoirs with variable oil phase viscosity

    Energy Technology Data Exchange (ETDEWEB)

    Gates, I.D. [Gushor Inc., Calgary, AB (Canada)]|[Calgary Univ., AB (Canada). Dept. of Chemical and Petroleum Engineering; Larter, S.R.; Adams, J.J.; Snowdon, L.; Jiang, C. [Gushor Inc., Calgary, AB (Canada)]|[Calgary Univ., Calgary, AB (Canada). Dept. of Geoscience

    2008-10-15

    This study investigated preconditioning techniques for altering reservoir fluid properties prior to steam assisted gravity drainage (SAGD) recovery processes. Viscosity-reducing agents were distributed in mobile reservoir water. Simulations were conducted to demonstrate the method's ability to modify oil viscosity prior to steam injection. The study simulated the action of water soluble organic solvents that preferentially partitioned in the oil phase. The solvent was injected with water into the reservoir in a slow waterflood that did not displace oil from the near wellbore region. A reservoir simulation model was used to investigate the technique. Shu's correlation was used to establish a viscosity correlation for the bitumen and solvent mixtures. Solvent injection was modelled by converting the oil phase viscosity through time. Over the first 2 years, oil rates of the preconditioned case were double that of the non-preconditioned case study. However, after 11 years, the preconditioned case's rates declined below rates observed in the non-preconditioned case. The model demonstrated that oil viscosity distributions were significantly altered using the preconditioners. The majority of the most viscous oil surrounding the production well was significantly reduced. It was concluded that accelerated steam chamber growth provided faster access to lower viscosity materials at the top of the reservoir. 12 refs., 9 figs.

  8. Phthalate esters contamination in soils and vegetables of plastic film greenhouses of suburb Nanjing, China and the potential human health risk.

    Science.gov (United States)

    Ma, Ting Ting; Wu, Long Hua; Chen, Like; Zhang, Hai Bo; Teng, Ying; Luo, Yong Ming

    2015-08-01

    The contamination of phthalate esters (PAEs) has become a potential threat to the environment and human health because they could be easily released as plasticizers from the daily supply products, especially in polyethylene films. Concentration levels of total six PAEs, nominated as priority pollutants by the US Environmental Protection Agency (USEPA), were investigated in soils and vegetables from four greenhouse areas in suburbs of Nanjing, East China. Total PAEs concentration ranged from 930 ± 840 to 2,450 ± 710 μg kg(-1) (dry weight (DW)) in soil and from 790 ± 630 to 3,010 ± 2,130 μg kg(-1) in vegetables. Higher concentrations of PAEs were found in soils except in Suo Shi (SS) area and in vegetables, especially in potherb mustard and purple tsai-tai samples. Risk assessment mainly based on the exposures of soil ingestion and daily vegetable intake indicated that bis(2-ethylhexyl) phthalate (DEHP) in the samples from Gu Li (GL) and Hu Shu (HS) exhibited the highest hazard to children less than 6-year old. Therefore, the human health risk of the PAEs contamination in soils and vegetables should greatly be of a concern, especially for their environmental estrogen analog effects.

  9. Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake.

    Science.gov (United States)

    Gotoh, Koro; Liu, Min; Benoit, Stephen C; Clegg, Deborah J; Davidson, W Sean; D'Alessio, David; Seeley, Randy J; Tso, Patrick; Woods, Stephen C

    2006-01-01

    Apolipoprotein (apo) A-IV is an anorexigenic gastrointestinal peptide that is also synthesized in the hypothalamus. The goal of these experiments was to determine whether apo A-IV interacts with the central melanocortin (MC) system in the control of feeding. The third ventricular (i3vt) administration of a subthreshold dose of apo A-IV (0.5 microg) potentiated i3vt MC-induced (metallothionein-II, 0.03 nmol) suppression of 30-min feeding in Long-Evans rats. A subthreshold dose of the MC antagonist (SHU9119, 0.1 nmol, i3vt) completely attenuated the anorectic effect of i3vt apo A-IV (1.5 microg). The i3vt apo A-IV significantly elevated the expression of c-Fos in neurons of the paraventricular nucleus of the hypothalamus, but not in the arcuate nucleus or median eminence. In addition, c-Fos expression was not colocalized with proopiomelanocortin-positive neurons. These data support a synergistic interaction between apo A-IV and melanocortins that reduces food intake by acting downstream of the arcuate.

  10. Cambiar el arte para cambiar el mundo (Una perspectiva feminista Diálogo abierto con Suzanne Lacy

    Directory of Open Access Journals (Sweden)

    Elena García-Oliveros

    2016-03-01

    Full Text Available Este artículo ahonda en la perspectiva activista y transformadora de las artistas feministas que surgieron en la década de los años 70, indagando en su particular visión acerca de la capacidad del arte para crear nuevos modelos sociales integradores. A partir del caso de la artista norteamericana Suzanne Lacy, con quien las autoras han mantenido diversos encuentros de carácter público en el Centro de Arte Contemporáneo Matadero de Madrid, se pormenorizan las estrategias que el feminismo ha trabado en torno al arte público y se busca una redefinición de los ejes principales que sustentan el medio artístico actual: la autoría, la obra y su difusión y el valor final de la pieza. La investigación continúa con los estudios de caso de la artista ciberfeminista Shu Lea Cheang, la artista de origen paraguayo Faith Wilding y el colectivo madrileño Toxic Lesbian.

  11. Molecular breeding of the Mureka-non-forming sake koji mold from Aspergillus oryzae by the disruption of the mreA gene.

    Science.gov (United States)

    Kubodera, Takafumi; Yamashita, Nobuo; Nishimura, Akira

    2003-01-01

    Mureka-non-forming sake koji molds were constructed from an Aspergillus oryzae industrial strain by the disruption of the mreA gene using a host-vector system with the ptrA gene as a dominant selectable marker. All of the mreA gene disruptants obtained retained the advantages of the host strain in terms of the brewing characteristics, while their isoamyl alcohol oxidase (IAAOD) activities were significantly lower than that of the host strain. Sake brewing was successfully carried out using the koji prepared with the disruptants, followed by storage of the resultant non-pasteurized sake (nama-shu). The isovaleraldehyde (i-Val) concentration in the sake brewed the host strain increased rapidly and reached the threshold values for mureka, 1.8 ppm and 2.6 ppm after storage at 20 degrees C for 42 d and 63 d, respectively, while those of the disruptants were less than 0.5 ppm even after storage at 20 degrees C or 30 degrees C for 63 d. In the sensory evaluation of the sake stored at 20 degrees C or 30 degrees C for 63 d, all members of the panel recognized the strong mureka flavor of the sake brewed with the host strain, while they did not detect this flavor in the sake brewed with the disruptants. Thus, we concluded that the mreA gene disruptants can be used for the production of sake in which mureka is not formed.

  12. Comorbidity and confounding factors in attention-deficit/hyperactivity disorder and sleep disorders in children

    Directory of Open Access Journals (Sweden)

    Huang YS

    2011-09-01

    Full Text Available Ya-Wen Jan1,2, Chien-Ming Yang1,3, Yu-Shu Huang4,51Department of Psychology, National Cheng-Chi University, Taipei; 2Sleep Center of Taipei Medical University Hospital, Taipei; 3The Research Center for Mind Brain and Learning, National Cheng-Chi University, Taipei; 4Department of Child Psychiatry and Sleep Center, Chang Gung Memorial Hospital, Taoyuan; 5College of Medicine, Chang Gung University, Taoyuan, TaiwanAbstract: Sleep problems are commonly reported in children with attention-deficit/hyperactivity disorder (ADHD symptoms. Research data regarding the complex and reciprocal relationship between ADHD and sleep disturbances has now accumulated. This paper is focused on the types of sleep problems that are associated with ADHD symptomatology, and attempts to untangle confounding factors and overlapping symptoms. The goal is also to present an updated overview of the pathophysiology of and treatment strategies for sleep problems in children with ADHD. The review also points out that future research will be needed to clarify further the other psychiatric comorbidities and side effects of medication in order to improve treatment outcomes and prevent misdiagnosis in clinical practice.Keywords: attention-deficit/hyperactivity disorder, sleep, children 

  13. MRI-guided targeting delivery of doxorubicin with reduction-responsive lipid-polymer hybrid nanoparticles

    Directory of Open Access Journals (Sweden)

    Wu B

    2017-09-01

    Full Text Available Bo Wu,1,2 Shu-Ting Lu,1 Kai Deng,2 Hui Yu,2 Can Cui,2 Yang Zhang,2 Ming Wu,2 Ren-Xi Zhuo,2 Hai-Bo Xu,1 Shi-Wen Huang2 1Department of Radiology, Zhongnan Hospital of Wuhan University, 2Key Laboratory of Biomedical Polymers, Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, People’s Republic of China Abstract: In recent years, there has been increasing interest in developing a multifunctional nanoscale platform for cancer monitoring and chemotherapy. However, there is still a big challenge for current clinic contrast agents to improve their poor tumor selectivity and response. Herein, we report a new kind of Gd complex and folate-coated redox-sensitive lipid-polymer hybrid nanoparticle (Gd-FLPNP for tumor-targeted magnetic resonance imaging and therapy. Gd-FLPNPs can simultaneously accomplish diagnostic imaging, and specific targeting and controlled release of doxorubicin (DOX. They exhibit good monodispersity, excellent size stability, and a well-defined core-shell structure. Paramagnetic nanoparticles based on gadolinium-diethylenetriaminepentaacetic acid-bis-cetylamine have paramagnetic properties with an approximately two-fold enhancement in the longitudinal relaxivity compared to clinical used Magnevist. For targeted and reduction-sensitive drug delivery, Gd-FLPNPs released DOX faster and enhanced cell uptake in vitro, and exhibited better antitumor effect both in vitro and in vivo. Keywords: redox-sensitive, tumor-targeted, gadolinium, contrast agents, PLGA

  14. Stability in Effects of gamma-Irradiated Chinese Medicinal Prescriptions on Protection of Mice from Radiation

    International Nuclear Information System (INIS)

    Yang Jung-Ah; Kim Sung-Ho

    2000-01-01

    The radioprotective effects of irradiated medicinal plants on biological system were studied to apply the irradiation technology for hygienic purpose that is usually performed by chemical preservatives. We previously reported that the three Chinese medicinal prescriptions, Si-Wu-Tang, Bu-Zhong-Yi-Qi-Tang and San-Ling-Bai-Shu-San, showed radioprotective effects in mice. In these experiments, to investigate the difference in radioprotective effects between irradiated (10 kGy) and non-irradiated medicinal plants, mice were administered with the irradiated or non-irradiated prescriptions and then the mice were exposed to gamma-rays with low and high dosage. Non-exposed mice were also prepared as a control. The effects of prescriptions on the jejunal crypt survival, endogenous spleen colony formation, and apoptosis of jejunal crypt cells in mice were investigated after exposure. All of the prescriptions showed the protective effects of the jejunal crypt (p0.05) and the adminstration of the prescriptions increased the formation of endogenous spleen colony (p0.05) and reduced the frequency of radiation-induced apoptosis (p0.05). No significant difference in effects between irradiated and non-irradiated prescreption on the parameters was found in mice administered with each prescription before exposure to gamma-rays. In non-exposed mice, there were no different findings in the parameters between irradiated and non-irradiated prescription

  15. Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells

    Directory of Open Access Journals (Sweden)

    Wang F

    2015-01-01

    Full Text Available Feng Wang,1,2 Hai Li,3 Xiao-Gang Yan,4 Zhi-Wei Zhou,2 Zhi-Gang Yi,5 Zhi-Xu He,6 Shu-Ting Pan,7 Yin-Xue Yang,3 Zuo-Zheng Wang,1 Xueji Zhang,8 Tianxing Yang,9 Jia-Xuan Qiu,7 Shu-Feng Zhou21Department of Hepatobiliary Surgery, General Hospital, Ningxia Medical University, Yinchuan, People’s Republic of China; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Department of Colorectal Surgery, General Hospital, Ningxia Medical University, 4Department of Oncological Surgery, The First People’s Hospital of Yinchuan, 5Department of General Surgery, Changqing Yangehu Hospital, Yinchuan, 6Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, 7Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, 8Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, People’s Republic of China; 9Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT, USAAbstract: Pancreatic cancer is the most aggressive cancer worldwide with poor response to current therapeutics. Alisertib (ALS, a potent and selective Aurora kinase A inhibitor, exhibits potent anticancer effects in preclinical and clinical studies; however, the effect and underlying mechanism of ALS in the pancreatic cancer treatment remain elusive. This study aimed to examine the effects of ALS on cell growth, autophagy, and epithelial-to-mesenchymal transition (EMT and to delineate the possible molecular mechanisms in human pancreatic cancer PANC-1 and BxPC-3 cells. The results showed that ALS exerted potent cell growth inhibitory, pro-autophagic, and EMT-suppressing effects in PANC-1 and BxPC-3 cells. ALS remarkably arrested PANC-1 and Bx

  16. 'BRS Mari': nova cultivar de pimenta dedo-de-moça para processamento 'BRS Mari': new hot pepper cultivar for processing

    Directory of Open Access Journals (Sweden)

    Sabrina Isabel C de Carvalho

    2009-12-01

    Full Text Available 'BRS Mari' é uma nova cultivar de pimenta dedo-de-moça desenvolvida para uso múltiplo, como produto in natura, processada na forma de molho líquido ou desidratada em flocos, moída junto com as sementes, para a produção de pimenta tipo 'calabresa'. A cv. 'BRS Mari' foi desenvolvida a partir da população 'CNPH 0039' por meio de seis ciclos de seleção massal com autofecundação controlada. A nova cultivar apresenta plantas de polinização aberta com hábito de crescimento intermediário, com aproximadamente 90 cm de altura e 1,25 m de largura, com resistência múltipla a doenças, com destaque para o virus Pepper Yellow Mosaic Virus (PepYMV e nematóide das galhas (Meloidogyne javanica, resistência mediana ao oídio (Oidium sicula, mancha bacteriana (Xanthomonas spp. e antracnose (Colletotrichum spp.. A colheita dos frutos tem início cerca de 70 dias após o transplante. Nas condições da região Centro-Oeste, 'BRS Mari' apresentou boa uniformidade de planta, ótima qualidade de fruto e grande potencial produtivo, alcançando 35 t ha-1 em seis meses, quando cultivada no espaçamento de 1 m entre plantas e 1,5 m entre linhas. Os frutos são alongados e pendentes, típicos do tipo dedo-de-moça, com passagem de coloração verde claro, amarelo com antocianina e laranja quando imaturos e vermelho intenso quando maduros, com aproximadamente 6,0 cm de comprimento, 1,4 cm de largura e cerca de 1,7 mm de espessura da parede. A principal característica da 'BRS Mari' é o elevado teor de capsaicina, aproximadamente 90.000 SHU (Unidades de Calor Scoville, mais elevado quando comparada com outras cultivares do mesmo grupo.'BRS Mari' is a new hot pepper cultivar suitable for processing as sauce or dehydrated flakes, ordinarily known in Brazil as 'calabresa' type, as well as for fresh market. Hot pepper cv. 'BRS Mari' was obtained from population 'CNPH 0039', through six cycles of mass selection with controlled selfing of selected plants. The

  17. Effects of multiple training modalities in patients with Alzheimer’s disease: a pilot study

    Directory of Open Access Journals (Sweden)

    Tai SY

    2016-11-01

    Full Text Available Shu-Yu Tai,1–4 Chia-Ling Hsu,5 Shu-Wan Huang,5 Tzu-Chiao Ma,6,7 Wen-Chien Hsieh,8,9 Yuan-Han Yang5,7,10,11 1Department of Family Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, 2Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 3Department of Family Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, 4Research Center for Environmental Medicine, Kaohsiung Medical University, 5Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, 6Graduate Institute of Oral Health Sciences, Kaohsiung Medical University, 7Mentality Protection Center, Fo Guang Shan Compassion Foundation, 8Department of Social Work, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, 9Department of Sociology and Social Work, Kaohsiung Medical University, 10Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 11Department of and Master’s Program in Neurology, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan Objective: This pilot study investigated the effects of multiple training modalities on cognition, neuropsychiatric symptoms, caregivers’ burden, and quality of life in patients with Alzheimer’s disease (AD.Patients and methods: This intervention study was conducted in 24 patients with AD aged ≥65 years with a Clinical Dementia Rating (CDR score of 0.5–1. The patients were assigned to receive multiple training modalities (1 hour for each training: Tai Chi, calligraphy, and drawing over a 6-week period in either the experimental group (n=14 or the comparison group (n=10. A series of neuropsychological tests – namely the Traditional Chinese version Mini-Mental Status Examination, Cognitive Assessment Screening Instrument (CASI, Neuropsychiatric Inventory and the Neuropsychiatric Inventory Caregiver Distress Scale, and the Clinical Dementia

  18. Neural mechanism of gastric motility regulation by electroacupuncture at RN12 and BL21: A paraventricular hypothalamic nucleus-dorsal vagal complex-vagus nerve-gastric channel pathway

    Science.gov (United States)

    Wang, Hao; Liu, Wen-Jian; Shen, Guo-Ming; Zhang, Meng-Ting; Huang, Shun; He, Ying

    2015-01-01

    AIM: To study the neural mechanism by which electroacupuncture (EA) at RN12 (Zhongwan) and BL21 (Weishu) regulates gastric motility. METHODS: One hundred and forty-four adult Sprague Dawley rats were studied in four separate experiments. Intragastric pressure was measured using custom-made rubber balloons, and extracellular neuron firing activity, which is sensitive to gastric distention in the dorsal vagal complex (DVC), was recorded by an electrophysiological technique. The expression levels of c-fos, motilin (MTL) and gastrin (GAS) in the paraventricular hypothalamic nucleus (PVN) were assayed by immunohistochemistry, and the expression levels of motilin receptor (MTL-R) and gastrin receptor (GAS-R) in both the PVN and the gastric antrum were assayed by western blotting. RESULTS: EA at RN12 + BL21 (gastric Shu and Mu points), BL21 (gastric Back-Shu point), RN12 (gastric Front-Mu point), resulted in increased neuron-activating frequency in the DVC (2.08 ± 0.050, 1.17 ± 0.023, 1.55 ± 0.079 vs 0.75 ± 0.046, P < 0.001) compared with a model group. The expression of c-fos (36.24 ± 1.67, 29.41 ± 2.55, 31.79 ± 3.00 vs 5.73 ± 2.18, P < 0.001), MTL (22.48 ± 2.66, 20.76 ± 2.41, 19.17 ± 1.71 vs 11.68 ± 2.52, P < 0.001), GAS (24.99 ± 2.95, 21.69 ± 3.24, 23.03 ± 3.09 vs 12.53 ± 2.15, P < 0.001), MTL-R (1.39 ± 0.05, 1.22 ± 0.05, 1.17 ± 0.12 vs 0.84 ± 0.06, P < 0.001), and GAS-R (1.07 ± 0.07, 0.91 ± 0.06, 0.78 ± 0.05 vs 0.45 ± 0.04, P < 0.001) increased in the PVN after EA compared with the model group. The expression of MTL-R (1.46 ± 0.14, 1.26 ± 0.11, 0.99 ± 0.07 vs 0.65 ± 0.03, P < 0.001), and GAS-R (1.63 ± 0.11, 1.26 ± 0.16, 1.13 ± 0.02 vs 0.80 ± 0.11, P < 0.001) increased in the gastric antrum after EA compared with the model group. Damaging the PVN resulted in reduced intragastric pressure (13.67 ± 3.72 vs 4.27 ± 1.48, P < 0.001). These data demonstrate that the signals induced by EA stimulation of acupoints RN12 and BL21 are detectable

  19. Síndrome hemolítico-urêmica relacionada à infecção invasiva pelo Streptococcus pneumoniae Hemolytic-uremic syndrome complicating invasive pneumococcal disease

    Directory of Open Access Journals (Sweden)

    Anna Leticia de O. Cestari

    2008-03-01

    Full Text Available OBJETIVO: A doença pneumocócica é importante problema de saúde pública e raramente há associação desta infecção com a síndrome hemolítico-urêmica (SHU grave. O objetivo deste artigo é relatar o caso de um paciente com esta associação. DESCRIÇÃO DO CASO: Criança do sexo masculino, com 17 meses de idade, admitida no hospital com insuficiência respiratória aguda e necessitando de suporte ventilatório. O exame radiológico mostrava extensa opacidade homogênea em hemitórax direito. A hemocultura foi positiva para Streptococcus pneumoniae. Nos exames de admissão, notaram-se: hemoglobina de 6,5g/dL, 38.000 plaquetas/mm³, uréia de 79mg/dL e creatinina de 1,64mg/dL. No primeiro dia, apresentou oligoanúria e hipervolemia, necessitando de hemodiafiltração. Evoluiu com disfunção de múltiplos órgãos e óbito no sétimo dia. A necrópsia mostrou áreas extensas de necrose cortical e tubular renal, com depósito de fibrina nas arteríolas. COMENTÁRIOS: A SHU associada ao pneumococo apresenta morbidade e mortalidade elevadas. Em crianças com doença pneumocócica invasiva e acometimento hematológico ou renal grave, deve-se estar atento a esta rara complicação. Merecem investigação os seguintes aspectos relacionados à doença: a função da detecção precoce de antígenos T ativados no diagnóstico e terapêutica, o papel do fator H na patogênese, o método ideal de substituição renal e a definição do prognóstico em longo prazo.OBJECTIVE: Pneumococcal diseases are a major public health problem. Severe hemolytic-uremic syndrome is an uncommon complication. The aim of this study is to report a child with this complication. CASE DESCRIPTION: A male child with 17 months old was admitted to the hospital, due to acute respiratory failure, needing ventilatory support. Roentgenogram demonstrated massive condensation of right lung and Streptococcus pneumonia was isolated from blood cultures. Laboratory tests showed

  20. Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells

    Directory of Open Access Journals (Sweden)

    Wang YY

    2015-02-01

    Full Text Available Yan-Yang Wang,1,2 Yin-Xue Yang,3 Ren Zhao,1 Shu-Ting Pan,2,4 Hong Zhe,1 Zhi-Xu He,5 Wei Duan,6 Xueji Zhang,7 Tianxin Yang,8 Jia-Xuan Qiu,4 Shu-Feng Zhou2,51Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Department of Colorectal Surgery, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China; 4Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, 5Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, People’s Republic of China; 6School of Medicine, Deakin University, Waurn Ponds, VIC, Australia; 7Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, People’s Republic of China; 8Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT, USAAbstract: Natural and synthetic triterpenoids have been shown to kill cancer cells via multiple mechanisms. The therapeutic effect and underlying mechanism of the synthetic triterpenoid bardoxolone methyl (C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid; CDDO-Me on esophageal cancer are unclear. Herein, we aimed to investigate the anticancer effects and underlying mechanisms of CDDO-Me in human esophageal squamous cell carcinoma (ESCC cells. Our study showed that CDDO-Me suppressed the proliferation and arrested cells in G2/M phase, and induced apoptosis in human ESCC Ec109 and KYSE70 cells. The G2/M arrest was accompanied with upregulated p21Waf1/Cip1 and p53 expression. CDDO-Me significantly decreased B-cell lymphoma-extra large (Bcl-xl, B-cell lymphoma 2 (Bcl-2

  1. Proteomic response to 5,6-dimethylxanthenone 4-acetic acid (DMXAA, vadimezan in human non-small cell lung cancer A549 cells determined by the stable-isotope labeling by amino acids in cell culture (SILAC approach

    Directory of Open Access Journals (Sweden)

    Pan ST

    2015-02-01

    Full Text Available Shu-Ting Pan,1,* Zhi-Wei Zhou,2,3,* Zhi-Xu He,3 Xueji Zhang,4 Tianxin Yang,5 Yin-Xue Yang,6 Dong Wang,7 Jia-Xuan Qiu,1 Shu-Feng Zhou2 1Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, 4Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, People’s Republic of China; 5Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT, USA; 6Department of Colorectal Surgery, General Hospital of Ningxia Medical University, Yinchuan, 7Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, People’s Republic of China *These two authors contributed equally to this work Abstract: 5,6-Dimethylxanthenone 4-acetic acid (DMXAA, also known as ASA404 and vadimezan, is a potent tumor blood vessel-disrupting agent and cytokine inducer used alone or in combination with other cytotoxic agents for the treatment of non-small cell lung cancer (NSCLC and other cancers. However, the latest Phase III clinical trial has shown frustrating outcomes in the treatment of NSCLC, since the therapeutic targets and underlying mechanism for the anticancer effect of DMXAA are not yet fully understood. This study aimed to examine the proteomic response to DMXAA and unveil the global molecular targets and possible mechanisms for the anticancer effect of DMXAA in NSCLC A549 cells using a stable-isotope labeling by amino acids in cell culture (SILAC approach. The proteomic data showed that treatment with DMXAA

  2. [Regularity of Clinical Application of Lianquan (CV 23) in Chinese Ancient Times According to Literature of Traditional Chinese Medicine].

    Science.gov (United States)

    Deng, Mei-Jun; Liu, Chun-Yan; Xie, Yu; Zhu, Jie-Bin; Xu, Zhen-Hua

    2018-03-25

    To summarize the regularity of application of Lianquan (CV 23) in clinical practice in Chinese ancient times through analysis of ancient traditional Chinese medical (TCM) literature. A total of 60 books involving CV 23 from the 1 156 ancient TCM books listed in the fifth edition of Encyclopedia of Traditional Chinese Medicine were collected by using CV 23 as the main keyword and "Sheben" "Benchi", and "Jieben" (the other names of CV 23 in TCM)as the supplementary keywords and analyzed systematically. A database was then constructed from the collected data, including the related types of disorders or symptoms, acupoint recipes, and methods of needling and moxibustion, contraindications, etc. A total of 196 articles related to the application of CV 23 from 60 ancient classical books were collected in accordance with the inclusive criteria. Among them, 155 articles are referred to the indications of CV 23, 35 to types of disorders such as asthma, cough, tongue swelling with difficulty in speaking, protracted tongue, acute contraction of tongue root, vomiting, spasm syndrome, stroke, aphtha, problems of mouth and teeth, throat problems, etc. of the internal medicine, surgery, pediatrics, and five-sense organs; 64 items are referred to the application of single CV 23, 91 to CV 23-included recipes containing 111 adjunct acupoints, and 78 to stimulation of CV 23 with acupuncture needle, moxibustion, pricking blood, and fire needle. Moreover, of the 111 adjunct acupoints, the most commonly used are Shaoshang (LU 11), Tiantu (CV 22), Hegu (LI 4), Yuye (EX-HN 13), Zhongchong (PC 9), etc. Lianquan (CV 23) is mainly used for glossopharyngeal problems chiefly by syndrome-meridian differentiation. The supplement of complementary acupoints or five-shu points in combination with CV 23 has a synergistic effect. Moxibustion (3 moxa- cones in general) is often employed, and the needling depth is usually about 7.5 mm. The common contraindication of CV 23 is severe tongue swelling.

  3. Effects of an anti-smoking program to prevent lung cancer among urban aboriginals in Taiwan.

    Science.gov (United States)

    Lin, Mei-Hsiang; Huang, Sheu-Jen; Shih, Whei-Mei Jean; Wang, Pao-Yu; Lin, Li-Hui; Hsu, Hsiu-Chin

    2013-01-01

    Indigenous people who leave their hometowns and move to the city to earn a living became urban aboriginals. During the process of adapting to urban living situations, they may use various coping strategies such as smoking to overcome their stress. Therefore, it is crucial to provide health education including smoking prevention, increasing knowledge regarding of tobacco hazard, self-efficacy of anti-smoking, and adjusting smoking behavior so as to empower their anti-smoking motivation to prevent lung cancer. The purpose of this study was to explore the effectiveness of an anti-smoking program on urban aboriginals in Taiwan. A quasi-experimental study design with purposeful sampling was employed. A total of 125 aboriginal subjects were recruited from two local churches at Shu Lin area in northern Taiwan. Subjects were divided into an experimental group (n =64 ) and a control group (n = 61). Both took pre-tests in order to set baseline values, and only the experimental group participated for 3-weeks in the anti-smoking program classes. Both groups took post-tests immediately after the intervention in order to evaluate the immediate effects of the teaching program, and a follow-up test was conducted four weeks after the intervention. Data were analyzed using descriptive statistics, one-way ANCOVA, and repeat measure ANCOVA. After controlling for confounding variables, the results showed that there were statistically significant differences in the self-efficacy of anti-smoking and smoking behavior between experimental and control groups in the immediately post-test and the follow-up test (p smoking at eiter time point. The findings of this study revealed that the anti-smoking program effectively improved self-efficacy of anti-smoking, and decreased the smoking behavior in urban aboriginals. They provide useful information as a reference regarding of aboriginal health promotion to health providers. It is imperative that anti-smoking be reinforced for those regular

  4. [Professor LAI Xinsheng's clinical experience in the treatment of premature ovarian failure with tongyuan acupuncture technique and Chinese herbal medicine].

    Science.gov (United States)

    Li, Xiaozhe; Zhang, Sujuan

    2017-03-12

    In the treatment of premature ovarian failure (POF), professor LAI Xinsheng focuses on the determination of syndrome to seek for etiology, associating with the differentiation of meridian and collateral and that of zangfu organs. Professor LAI believes that POF is mainly manifested as amenorrhea and infertility, localized in the kidney, with the dysfunction of liver, spleen and heart. It is impacted by many pathological factors, such as cold blockage, qi stagnation, blood stagnation, blood deficiency, yin deficiency, etc., which leads to the damage of the thoroughfare vessel and the conception vessel and the blockage of menstrual flow. On the basis of four diagnostic Methods and syndrome differentiation, there are four common syndromes of POF, named qi and blood deficiency, qi and blood stagnation, liver and kidney deficiency and yang deficiency of spleen and kidney. Tongyuan acupuncture technique is summarized by Professor LAI Xinsheng on the basis of yinyang theory. It is an effective and scientific method for acupoint selection along the meridians. The acupoints on the back, communicating with the governor vessel and mind regulation, acting on the brain are selected to promote yang qi of the governor vessel. The back- shu points of five zang organs are selected to regulate the functions of internal organs. The acupoints on the abdomen and the conception vessel are selected to conduce qi to the primary so as to improve reproductive function. In the guidance of tongyuan acupuncture technique, the acupoint prescription is formed and the Chinese herbal medicines are selected in combination to improve ovarian function and regulate menstruation. Hence, the satisfactory therapeutic effects have been achieved.

  5. Robust second-order scheme for multi-phase flow computations

    Science.gov (United States)

    Shahbazi, Khosro

    2017-06-01

    A robust high-order scheme for the multi-phase flow computations featuring jumps and discontinuities due to shock waves and phase interfaces is presented. The scheme is based on high-order weighted-essentially non-oscillatory (WENO) finite volume schemes and high-order limiters to ensure the maximum principle or positivity of the various field variables including the density, pressure, and order parameters identifying each phase. The two-phase flow model considered besides the Euler equations of gas dynamics consists of advection of two parameters of the stiffened-gas equation of states, characterizing each phase. The design of the high-order limiter is guided by the findings of Zhang and Shu (2011) [36], and is based on limiting the quadrature values of the density, pressure and order parameters reconstructed using a high-order WENO scheme. The proof of positivity-preserving and accuracy is given, and the convergence and the robustness of the scheme are illustrated using the smooth isentropic vortex problem with very small density and pressure. The effectiveness and robustness of the scheme in computing the challenging problem of shock wave interaction with a cluster of tightly packed air or helium bubbles placed in a body of liquid water is also demonstrated. The superior performance of the high-order schemes over the first-order Lax-Friedrichs scheme for computations of shock-bubble interaction is also shown. The scheme is implemented in two-dimensional space on parallel computers using message passing interface (MPI). The proposed scheme with limiter features approximately 50% higher number of inter-processor message communications compared to the corresponding scheme without limiter, but with only 10% higher total CPU time. The scheme is provably second-order accurate in regions requiring positivity enforcement and higher order in the rest of domain.

  6. Uranium ores of Kazakhstan as the most technologic source of a fissionable material

    International Nuclear Information System (INIS)

    Berikbolov, B.R.

    1999-01-01

    Kazakhstan as is known has unique deposits of uranium. Its resources composed a third part of the world resources. The most important part of resources having a practical value, is related with depression in southern regions of the Republic. By now more than 15 deposits are discovered and partially explored. These deposits from three uranium provinces - Shu-Sarysu, Syr-Darya and Ili. The ores occur in friable water-bearing sandy horizons of Cretaceous and Paleogene age between waterproof agrillaceous sediments at depth from 100 up to 600 m. Ore bodies thickness changes from 5 to 10 m at uranian average-grade 0.03-0.1 %. Width of band shaped ore bodies changes from tens meters to the one kilometers and extent changes from one kilometer up to many tens kilometers. The important feature of deposits is their suitability for development by progressive in situ leaching (ISL) method. It was demonstrated, that uranium ores are comprehensive and, that is important, a lot of commercially important elements, containing in ores, gives in to extraction at development by the ISL method. The preliminary calculation of expenditures for the extraction of useful byproducts from ordinary sulphate solution have demonstrated rather high profitableness for rhenium, scandium, selenium, rare earth even at the very low contents in solution. It was pointed out, that whole technological chain applied now at industrial scale is oriented to mono-metallic uranium ores, therefore present technology of leaching and recovery of industrial solution does not allow ti extract all valuable components containing in ores. The development of new improved technological chain. beginning with a composition of leaching out reagent and up to applying of miscellaneous sorbing materials, can create new mineral-raw base of rare and dissipated elements and to lower considerably the price of uranium mining from sandstone deposits

  7. A magnetically responsive nanocomposite scaffold combined with Schwann cells promotes sciatic nerve regeneration upon exposure to magnetic field

    Directory of Open Access Journals (Sweden)

    Liu ZY

    2017-10-01

    Full Text Available Zhongyang Liu,1,* Shu Zhu,1,* Liang Liu,2,* Jun Ge,3,4,* Liangliang Huang,1 Zhen Sun,1 Wen Zeng,5 Jinghui Huang,1 Zhuojing Luo1 1Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, 2Department of Orthopedics, No 161 Hospital of PLA, Wuhan, Hubei, 3Department of Orthopedics, No 323 Hospital of PLA, Xi’an, Shaanxi, 4Department of Anatomy, Fourth Military Medical University, Xi’an, Shaanxi, 5Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi, People’s Republic of China *These authors contributed equally to this work Abstract: Peripheral nerve repair is still challenging for surgeons. Autologous nerve transplantation is the acknowledged therapy; however, its application is limited by the scarcity of available donor nerves, donor area morbidity, and neuroma formation. Biomaterials for engineering artificial nerves, particularly materials combined with supportive cells, display remarkable promising prospects. Schwann cells (SCs are the absorbing seeding cells in peripheral nerve engineering repair; however, the attenuated biologic activity restricts their application. In this study, a magnetic nanocomposite scaffold fabricated from magnetic nanoparticles and a biodegradable chitosan–glycerophosphate polymer was made. Its structure was evaluated and characterized. The combined effects of magnetic scaffold (MG with an applied magnetic field (MF on the viability of SCs and peripheral nerve injury repair were investigated. The magnetic nanocomposite scaffold showed tunable magnetization and degradation rate. The MGs synergized with the applied MF to enhance the viability of SCs after transplantation. Furthermore, nerve regeneration and functional recovery were promoted by the synergism of SCs-loaded MGs and MF. Based on the current findings, the combined application of MGs and SCs with applied MF is a promising therapy for the engineering of peripheral

  8. Nanoparticle abraxane possesses impaired proliferation in A549 cells due to the underexpression of glucosamine 6-phosphate N-acetyltransferase 1 (GNPNAT1/GNA1

    Directory of Open Access Journals (Sweden)

    Zhao MZ

    2017-03-01

    Full Text Available Minzhi Zhao,* Haiyun Li,* Yan Ma, He Gong, Shu Yang, Qiaojun Fang, Zhiyuan Hu Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, People’s Republic of China *These authors contributed equally to this work Abstract: Abraxane (Abr, a US Food and Drug Administration-approved albumin-bound nanoparticle applied for the treatment of non-small-cell lung cancer, has been reported to be more effective than paclitaxel (PTX. To further understand the molecular mechanisms that produce this superior drug efficacy of Abr, a quantitative proteomic approach has been applied to investigate the global protein expression profiles of lung cancer cell A549 treated with Abr and PTX. Only one protein, namely, glucosamine 6-phosphate N-acetyltransferase 1 (GNA1, showed significant differential expression (P<0.05 in the cutoff of 2.0 fold, suggesting that Abr can be used safely as a substitute for PTX. GNA1 is a key enzyme in the biosynthesis of uridine diphosphate-N-acetylglucosamine, which is an important donor substrate for N-linked glycosylation and has several important functions such as embryonic development and growth. Albumin plays a major role in the regulation of this protein. In summary, this study first shows that the superior drug effect of Abr is mainly due to the downregulation of GNA1, which causes proliferative delay and cell adhesion defect. It is also noteworthy that the deficiency of GNA1 might reduce insulin secretion which correlates with type 2 diabetes. Keywords: quantitative proteomics, nano-drug, drug efficacy, lung cancer, molecular mechanisms, abraxane

  9. Efficacy and safety of nanohybrids comprising silver nanoparticles and silicate clay for controlling Salmonella infection

    Directory of Open Access Journals (Sweden)

    Bau IJ

    2012-05-01

    Full Text Available Shu-Her Chiao,1* Siou-Hong Lin,1* Ching-I Shen,2* Jiunn-Wang Liao,3 I-Jiuan Bau,1 Jiun-Chiou Wei,4 Li-Ping Tseng,1 Shan-hui Hsu,4 Ping-Shan Lai,2 Shinn-Zong Lin,5–7 Jiang-Jen Lin,4 Hong-Lin Su,1,8 1Department of Life Sciences, Agricultural Biotechnology Center, National Chung Hsing University, 2Department of Chemistry, Agricultural Biotechnology Center, National Chung Hsing University, 3Graduate Institute of Veterinary Pathobiology, Agricultural Biotechnology Center, National Chung Hsing University, Taichung, Taiwan; 4Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan; 5Center for Neuropsychiatry, China Medical University and Hospital, Taichung, Taiwan; 6Department of Neurosurgery, China Medical University Beigan Hospital, Yunlin, Taiwan; 7Graduate Institute of Immunology, China Medical University, Taichung, Taiwan; 8Department of Physical Therapy, China Medical University, Taichung, Taiwan*These three authors contributed equallyAbstract: Developing effective and safe drugs is imperative for replacing antibiotics and controlling multidrug-resistant microbes. Nanoscale silicate platelet (NSP and its nanohybrid, silver nanoparticle/NSP (AgNP/NSP, have been developed, and the nanohybrids show a strong and general antibacterial activity in vitro. Here, their efficacy for protecting Salmonella-infected chicks from fatality and septicemia was evaluated. Both orally administrated NSP and AgNP/NSP, but not AgNPs alone, effectively reduced the systemic Salmonella infection and mortality. In addition, quantitative Ag analyses demonstrated that Ag deposition from AgNP/NSP in the intestines was less than that from conventional AgNPs, indicating that the presence of NSP for immobilizing AgNPs reduced Ag accumulation in tissue and improved the safety of AgNPs. These in vivo results illustrated that both NSP and AgNP/NSP nanohybrid represent potential agents for controlling enteric bacterial infections.Keywords: silver

  10. 《采薇》的叙事伦理分析%Narrative Ethics of Cai Wei

    Institute of Scientific and Technical Information of China (English)

    王海燕

    2014-01-01

    The controversial dilemma of how to understand Boyi, Shuqi in Luxun’ s novel Cai Wei, it is not a realistic ethical problem, which should be based on the novel's narrative ethics to answer. Narrative ethics refers to various forms of arrangement of ethical dimension revealed. Novel manifests sympathy ethics to Boyi, Shu Qi through the narrative angle choice and narrative distance controlling. Also, by the counterpoint to character, event and ironic expression in structure, novel conveys the ethics excluding to all sorts of characters from emperor Zhouwu to A Jin. Compared to other “Generational change” theme novels of Luxun, the complication of narrative ethics of Cai Wei not only is the projection of reality, but also reflects the further conscious to narrative art of Luxun.%《采薇》中颇有争议的“如何理解伯夷、叔齐”这一难点,并不是一个现实伦理问题,而应依据小说的叙事伦理来解答。叙事伦理即各种形式安排透露出的伦理维度。小说通过叙事角度的选择与叙事距离的控制体现出对伯夷、叔齐的伦理同情,而由结构上的人物对位与事件对位及反讽表达的是对自周武王至阿金诸色人物的伦理拒斥。与前期同是“易代”主题的小说相比,《采薇》叙事伦理的复杂化既是现实的投射,也体现了鲁迅对于小说叙事艺术的进一步自觉。

  11. Phosphoglycerate dehydrogenase is a novel predictor for poor prognosis in gastric cancer

    Directory of Open Access Journals (Sweden)

    Xian Y

    2016-09-01

    Full Text Available Yun Xian,1,* Shu Zhang,2,* Xudong Wang,3 Jin Qin,2 Wei Wang,2 Han Wu4 1School of Public Health, Nantong University, 2Department of Pathology, 3Department of Laboratory Medicine, 4Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People’s Republic of China *These authors contributed equally to this work Purpose: Phosphoglycerate dehydrogenase (PHGDH acts as a key metabolic enzyme in the rate-limiting step in serine biosynthesis and plays an important role in metastasis of several cancers. The aim of this study was to investigate the prognostic value of PHGDH in gastric cancer (GC. Methods: The messenger RNA expression of PHGDH was determined in 20 pairs of cancerous and adjacent nontumor tissues by real-time polymerase chain reaction. Immunohistochemistry of PHGDH was performed on tissue microarray, composed of 482 GC and 64 matched adjacent nontumor tissues acquired from surgery, 20 chronic gastritis, 18 intestinal metaplasia, and 31 low-grade and 66 high-grade intraepithelial neoplasias acquired through gastric endoscopic biopsy. Univariate and multivariate Cox proportional hazard models were used to perform survival analyses. Results: Both PHGDH messenger RNA and protein product exhibited GC tissue-preferred expression, when compared with benign tissues. The high PHGDH expression was significantly correlated with histological type (P=0.011, tumor stage (P=0.014, and preoperative carcinoembryonic antigen (P<0.001. A negative correlation was found between PHGDH expression and the 5-year survival rate of patients with GC. Furthermore, multivariate analysis indicated that PHGDH was an independent prognostic factor for outcome in GC. Conclusion: PHGDH is important in predicting patient outcomes and is a potential target for the development of therapeutic approaches to GC. Keywords: metabolism, gastric cancer, prognosis, serine biosynthesis

  12. Anxiety and mood disorder in young males with mitral valve prolapse

    Directory of Open Access Journals (Sweden)

    For-Wey Lung

    2008-10-01

    Full Text Available For-Wey Lung1–4, Chih-Tao Cheng5, Wei-To Chang6, Bih-Ching Shu71Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan; 2Graduate Institute of Behavioral Sciences, Kaohsiung Medical Center, Taiwan; 3Department of Psychiatry, National Defense Medical Center, Taipei, Taiwan; 4Calo Psychiatric Center, Pingtung County, Taiwan; 5School of public Health, University of California, Berkeley, CA, USA; 6Liu Chia-Hsiu Hospital, Kaohsiung County, Taiwan; 7Institute of Allied Health Sciences and Department of Nursing, National Cheng Kung University, Tainan, TaiwanObjective: This study explored the prevalence of panic disorder and other psychiatric disorders in young Han Chinese males with mitral valve prolapse (MVP. With the factors of age, sex, and ethnicity controlled, the specific role of MVP in panic disorder was analyzed. Methods: Subjects with chest pain aged between 18 and 25 years were assessed with the echocardiograph for MVP and the Chinese version of the Mini-International Neuropsychiatric Interview for panic disorder (n = 39.Results: Of the 39 participants, 35.9% met the diagnosis of anxiety disorder, 46.2% met at least one criterion of anxiety disorder, and 23.1% met the diagnostic criteria of major depressive disorder. There was no statistically significant difference in the prevalence of panic disorder between one of the (8.3% MVP patients, and two (7.4% control participants.Conclusions: There is a high prevalence of psychiatric disorder, including anxiety disorder and major depressive disorder, in those who report pain symptoms, so that diagnosis and treatment of these patients is of great importance. In addition, individuals with MVP did not have an increased risk for panic disorder. Whether MVP may be a modifier or mediating factor for panic disorder needs to be further assessed in a larger scale study.Keywords: mitral valve prolapse, panic disorder, Han Chinese males, major depressive disorder

  13. Recent progress on the effects of microRNAs and natural products on tumor epithelial–mesenchymal transition

    Directory of Open Access Journals (Sweden)

    He SJ

    2017-07-01

    Full Text Available Shu-Jin He,1,2,* Chu-Qi Xiang,1,3,* Yu Zhang,3 Xiang-Tong Lu,1 Hou-Wen Chen,1,4 Li-Xia Xiong1,4 1Department of Pathophysiology, Medical College, Nanchang University, 2Second Clinical Medical College, Nanchang University, 3First Clinical Medical College, Nanchang University, 4Jiangxi Province Key Laboratory of Tumor Pathogenesis and Molecular Pathology, Nanchang, People’s Republic of China *These authors contributed equally to this work Abstract: Epithelial–mesenchymal transition (EMT is a biological process of phenotypic transition of epithelial cells that can promote physiological development as well as tissue healing and repair. In recent years, cancer researchers have noted that EMT is closely related to the occurrence and development of tumors. When tumor cells undergo EMT, they can develop enhanced migration and local tissue invasion abilities, which can lead to metastatic growth. Nevertheless, two researches in NATURE deny its necessity in specific tumors and that is discussed in this review. The degree of EMT and the detection of EMT-associated marker molecules can also be used to judge the risk of metastasis and to evaluate patients’ prognosis. MicroRNAs (miRNAs are noncoding small RNAs, which can inhibit gene expression and protein translation through specific binding with the 3' untranslated region of mRNA. In this review, we summarize the miRNAs that are reported to influence EMT through transcription factors such as ZEB, SNAIL, and TWIST, as well as some natural products that regulate EMT in tumors. Moreover, mutual inhibition occurs between some transcription factors and miRNAs, and these effects appear to occur in a complex regulatory network. Thus, understanding the role of miRNAs in EMT and tumor growth may lead to new treatments for malignancies. Natural products can also be combined with conventional chemotherapy to enhance curative effects. Keywords: epithelial–mesenchymal transition, miRNA, tumor, natural products

  14. Posttranslational regulation of phosphatase and tensin homolog (PTEN and its functional impact on cancer behaviors

    Directory of Open Access Journals (Sweden)

    Xu WT

    2014-10-01

    Full Text Available Wenting Xu,1 Zhen Yang,1 Shu-Feng Zhou,2 Nonghua Lu1 1Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA Abstract: The incidence of cancer is increasing worldwide, but the biochemical mechanisms for the occurrence of cancer is not fully understood, and there is no cure for advanced tumors. Defects of posttranslational modifications of proteins are linked to a number of important diseases, such as cancer. This review will update our knowledge on the critical role of posttranscriptional regulation of phosphatase and tensin homolog (PTEN and its activities and the functional impact on cancer behaviors. PTEN is a tumor suppressor gene that occupies a key position in regulating cell growth, proliferation, apoptosis, mobility, signal transduction, and other crucial cellular processes. The activity and function of PTEN are regulated by coordinated epigenetic, transcriptional, posttranscriptional, and posttranslational modifications. In particular, PTEN is subject to phosphorylation, ubiquitylation, somoylation, acetylation, and active site oxidation. Posttranslational modifications of PTEN can dynamically change its activity and function. Deficiency in the posttranslational regulation of PTEN leads to abnormal cell proliferation, apoptosis, migration, and adhesion, which are associated with cancer initiation, progression, and metastasis. With increasing information on how PTEN is regulated by multiple mechanisms and networked proteins, its exact role in cancer initiation, growth, and metastasis will be revealed. PTEN and its functionally related proteins may represent useful targets for the discovery of new anticancer drugs, and gene therapy and the therapeutic potentials should be fully explored. Keywords: phosphorylation, ubiquitination, acetylation, oxidation

  15. Systemic N-terminal fragments of adrenocorticotropin reduce inflammation- and stress-induced anhedonia in rats.

    Science.gov (United States)

    Markov, Dmitrii D; Yatsenko, Ksenia A; Inozemtseva, Lyudmila S; Grivennikov, Igor A; Myasoedov, Nikolai F; Dolotov, Oleg V

    2017-08-01

    Emerging evidence implicates impaired self-regulation of the hypothalamic-pituitary-adrenal (HPA) axis and inflammation as important and closely related components of the pathophysiology of major depression. Antidepressants show anti-inflammatory effects and are suggested to enhance glucocorticoid feedback inhibition of the HPA axis. HPA axis activity is also negatively self-regulated by the adrenocorticotropic hormone (ACTH), a potent anti-inflammatory peptide activating five subtypes of melanocortin receptors (MCRs). There are indications that ACTH-mediated feedback can be activated by noncorticotropic N-terminal ACTH fragments such as a potent anti-inflammatory MC1/3/4/5R agonist α-melanocyte-stimulating hormone (α-MSH), corresponding to ACTH(1-13), and a MC3/5R agonist ACTH(4-10). We investigated whether intraperitoneal administration of rats with these peptides affects anhedonia, which is a core symptom of depression. Inflammation-related anhedonia was induced by a single intraperitoneal administration of a low dose (0.025mg/kg) of lipopolysaccharide (LPS). Stress-related anhedonia was induced by the chronic unpredictable stress (CUS) procedure. The sucrose preference test was used to detect anhedonia. We found that ACTH(4-10) pretreatment decreased LPS-induced increase in serum corticosterone and tumor necrosis factor (TNF)-α, and a MC3/4R antagonist SHU9119 blocked this effect. Both α-MSH and ACTH(4-10) alleviated LPS-induced anhedonia. In the CUS model, these peptides reduced anhedonia and normalized body weight gain. The data indicate that systemic α-MSH and ACTH(4-10) produce an antidepressant-like effect on anhedonia induced by stress or inflammation, the stimuli that trigger the release of ACTH and α-MSH into the bloodstream. The results suggest a counterbalancing role of circulating melanocortins in depression and point to a new approach for antidepressant treatment. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. On dermatomes, meridians and points: results of a quasiexperimental study.

    Science.gov (United States)

    Sánchez-Araujo, Max; Luckert-Barela, Ana J; Sánchez, Nathalia; Torres, Juan; Conde, Jesus Eloy

    2014-02-01

    Traditional Chinese medicine (TCM) meridians and points run vertically, reflecting their function in the Zhang-Fu system (meridian pattern). However, the trunk's spinal nerves show a traverse orientation, or a 'horizontal pattern'. The aim of the present work was to evaluate, via a cognitive quasiexperiment, whether the clinical indications of the points on the trunk are associated with their meridian function or with their innervation and visceral-somatic connection. The points in each dermatome of the trunk were considered crosswise, regardless of their meridians. The clinical indications for each point were differentiated into two mutually exclusive categories: (a) vertical distribution effect (VDE) or 'meridian pattern', when indications were quite different regarding the indications for the other points on the dermatome; and (b) transverse distribution effects (TDE) or 'horizontal pattern', represented by mainly local or segmental indications except for Shu-Mu points. After observing that the proportions between both categories often exceeded 60% in pilot samples, 60% was adopted as the reference value. A total of 22 dermatomes accommodated 148 points with 809 indications, of which 189 indications (23.4%) exhibited VDE features, whereas 620 (76.6%) exhibited TDE features. A TDE/VDE ratio of 3 : 1 implies that the clinical indications for the points of any dermatome on the torso are similar, regardless of their meridians, and suggests that most of the indications for trunk points involve a 'horizontal pattern' due to their neurobiological nature. These findings may help in understanding acupuncture's neurobiology and clarify some confusing results of clinical research, for example, excluding sham acupuncture as an inert intervention for future clinical trials.

  17. HIERARCHICAL GRAVITATIONAL FRAGMENTATION. I. COLLAPSING CORES WITHIN COLLAPSING CLOUDS

    Energy Technology Data Exchange (ETDEWEB)

    Naranjo-Romero, Raúl; Vázquez-Semadeni, Enrique; Loughnane, Robert M. [Instituto de Radioastronomía y Astrofísica, Universidad Nacional Autónoma de México, Apdo. Postal 3-72, Morelia, Michoacán, 58089, México (Mexico)

    2015-11-20

    We investigate the Hierarchical Gravitational Fragmentation scenario through numerical simulations of the prestellar stages of the collapse of a marginally gravitationally unstable isothermal sphere immersed in a strongly gravitationally unstable, uniform background medium. The core developes a Bonnor–Ebert (BE)-like density profile, while at the time of singularity (the protostar) formation the envelope approaches a singular-isothermal-sphere (SIS)-like r{sup −2} density profile. However, these structures are never hydrostatic. In this case, the central flat region is characterized by an infall speed, while the envelope is characterized by a uniform speed. This implies that the hydrostatic SIS initial condition leading to Shu's classical inside-out solution is not expected to occur, and therefore neither should the inside-out solution. Instead, the solution collapses from the outside-in, naturally explaining the observation of extended infall velocities. The core, defined by the radius at which it merges with the background, has a time-variable mass, and evolves along the locus of the ensemble of observed prestellar cores in a plot of M/M{sub BE} versus M, where M is the core's mass and M{sub BE} is the critical BE mass, spanning the range from the “stable” to the “unstable” regimes, even though it is collapsing at all times. We conclude that the presence of an unstable background allows a core to evolve dynamically from the time when it first appears, even when it resembles a pressure-confined, stable BE-sphere. The core can be thought of as a ram-pressure confined BE-sphere, with an increasing mass due to the accretion from the unstable background.

  18. Design, synthesis, and structure–activity relationships of 2-benzylidene-1-indanone derivatives as anti-inflammatory agents for treatment of acute lung injury

    Directory of Open Access Journals (Sweden)

    Xiao S

    2018-04-01

    Full Text Available Siyang Xiao,1,* Wenxin Zhang,1,* Hongjin Chen,1 Bo Fang,1 Yinda Qiu,2 Xianxin Chen,1 Lingfeng Chen,1 Sheng Shu,1 Yunjie Zhao,1 Zhiguo Liu,1 Guang Liang1 1Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China; 2College of Life and Environmental Science, Wenzhou University, Wenzhou, Zhejiang, China *These authors contributed equally to this work Purpose: The purpose of this study was to design and synthesize novel 2-benzylidene-1-indanone derivatives for treatment of acute lung injury. Methods: A series of 39 novel 2-benzylidene-indanone structural derivatives were synthesized and evaluated for anti-inflammatory activity in lipopolysaccharide (LPS-stimulated murine primary macrophages. Results: Most of the obtained compounds effectively inhibited the LPS-induced expression of IL-6 and TNF-α. The most active compound, 8f, was found to significantly reduce LPS-induced pulmonary inflammation, as reflected by reductions in the concentration of total protein, inflammatory cell count, as well as the lung wet/dry ratio in bronchoalveolar lavage (BAL fluid. Furthermore, 8f effectively inhibited mRNA expression of several inflammatory cytokines after LPS challenge in vitro and in vivo. Administration of 8f also blocked LPS-induced activation of the proinflammatory NF-κB/MAPK signaling pathway. Conclusion: The simple synthetic preparation and biological properties of these derivatives make these 2-benzylidene-indanone scaffolds promising new entities for the development of anti-inflammatory therapeutics for the treatment of acute lung injury. Keywords: indanone, acute lung injury, drug design, anti-inflammation, synthesis

  19. Gas-phase rate coefficients of the reaction of ozone with four sesquiterpenes at 295 ± 2 K.

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    Richters, Stefanie; Herrmann, Hartmut; Berndt, Torsten

    2015-05-07

    The rate coefficients of the reaction of ozone with the four atmospherically relevant sesquiterpenes β-caryophyllene, α-humulene, α-cedrene and isolongifolene were investigated at 295 ± 2 K and atmospheric pressure by at least two independent experimental investigations for each reaction. Relative rate experiments were carried out in a flow tube using two different experimental approaches with GC-MS detection (RR 1) and PTR-MS analysis (RR 2) as the analytical techniques. Absolute rate coefficients were determined in a stopped-flow experiment following the ozone depletion by means of UV spectroscopy. The average rate coefficients from the combined investigations representing the mean values of the different experimental methods are (unit: cm(3) molecule(-1) s(-1)): k(O3+β-caryophyllene) = (1.1 ± 0.3) × 10(-14) (methods: RR 1, RR 2, absolute), k(O3+α-humulene) = (1.2 ± 0.3) × 10(-14) (RR 1, RR 2), k(O3+α-cedrene) = (1.7 ± 0.5) × 10(-16) (RR 2, absolute) and k(O3+isolongifolene) = (1.1 ± 0.5) × 10(-17) (RR 2, absolute). The high ozonolysis rate coefficients for β-caryophyllene and α-humulene agree well with the results by Shu and Atkinson (Int. J. Chem. Kinet., 1994, 26) and lead to short atmospheric lifetimes of about two minutes with respect to the ozone reaction. The relatively small rate coefficients for α-cedrene and isolongifolene differ from the available literature values by a factor of about 2.5-6. Possible reasons for the deviations are discussed. Finally, calibrated sesquiterpene FT-IR spectra were recorded for the first time.

  20. Downregulation of ALDOB is associated with poor prognosis of patients with gastric cancer

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    He J

    2016-10-01

    Full Text Available Jun He,1 Yi Jin,1 Yuan Chen,2 Hai-Bo Yao,1 Ying-Jie Xia,3 Ying-Yu Ma,4 Wei Wang,2 Qin-Shu Shao1 1Department of Gastroenterology and Pancreatic Surgery, 2Department of Pathology, 3Key Laboratory of Gastroenterology of Zhejiang Province, 4Clinic Research Institute, Zhejiang Provincial People’s Hospital, Hangzhou, People’s Republic of China Objectives: To examine the expression of ALDOB in gastric cancer (GC tissue and to reveal its potential clinicopathological and prognostic significance.Materials and methods: We screened for genes that were differentially expressed between GC and nontumor tissues using a microarray, specifically the Affymetrix U133 Plus 2.0 Array platform. We then verified the transcriptional and translational levels of ALDOB by performing quantitative real-time polymerase chain reaction (qRT-PCR and immunohistochemistry (IHC. In addition, a merged data set based on the Gene Expression Omnibus was generated and a survival analysis performed.Results: The microarray analysis revealed that ALDOB was downregulated (more than sevenfold in GC compared with nontumor tissue. Both qRT-PCR and IHC validated the decrease of ALDOB in GC tissue. Moreover, we found that the expression of ALDOB was significantly related to tumor-invasion depth, lymph-node metastasis, distant metastasis, and TNM stage. The survival analysis, based on the IHC and merged data set, indicated that the overall survival was better in patients with high ALDOB expression. The Cox regression analysis showed that ALDOB expression was an independent prognostic factor for GC.Conclusion: The expression of ALDOB in GC tissue was significantly related to the clinicopathological features and prognosis of the disease, thus suggesting that ALDOB could act as a novel molecular marker for GC. Keywords: ALDOB, gastric cancer, microarray analysis, molecular marker

  1. The Readability of Electronic Cigarette Health Information and Advice: A Quantitative Analysis of Web-Based Information.

    Science.gov (United States)

    Park, Albert; Zhu, Shu-Hong; Conway, Mike

    2017-01-06

    The popularity and use of electronic cigarettes (e-cigarettes) has increased across all demographic groups in recent years. However, little is currently known about the readability of health information and advice aimed at the general public regarding the use of e-cigarettes. The objective of our study was to examine the readability of publicly available health information as well as advice on e-cigarettes. We compared information and advice available from US government agencies, nongovernment organizations, English speaking government agencies outside the United States, and for-profit entities. A systematic search for health information and advice on e-cigarettes was conducted using search engines. We manually verified search results and converted to plain text for analysis. We then assessed readability of the collected documents using 4 readability metrics followed by pairwise comparisons of groups with adjustment for multiple comparisons. A total of 54 documents were collected for this study. All 4 readability metrics indicate that all information and advice on e-cigarette use is written at a level higher than that recommended for the general public by National Institutes of Health (NIH) communication guidelines. However, health information and advice written by for-profit entities, many of which were promoting e-cigarettes, were significantly easier to read. A substantial proportion of potential and current e-cigarette users are likely to have difficulty in fully comprehending Web-based health information regarding e-cigarettes, potentially hindering effective health-seeking behaviors. To comply with NIH communication guidelines, government entities and nongovernment organizations would benefit from improving the readability of e-cigarettes information and advice. ©Albert Park, Shu-Hong Zhu, Mike Conway. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 06.01.2017.

  2. Post-earthquake denudation and its impacts on ancient civilizations in the Chengdu Longmenshan region, China

    Science.gov (United States)

    Chen, Ningsheng; Li, Jun; Liu, Lihong; Yang, Chenglin; Liu, Mei

    2018-05-01

    This study characterizes significant changes in denudation and disasters in mountainous areas induced in the humid Chengdu Longmenshan region by the Wenchuan Earthquake in 2008. A study focusing on the Longxi-Baisha River Basin was conducted to investigate the amount of denudation triggered by specific flash flood and debris flow events in 2009-2014. The following results were obtained through a comparison of pre-seismic regional denudation rates and denudation characteristics of other seismically active mountain regions. (1) Regional denudation processes occurred in a wave-like process of initial increase then decline, with a peak exhibiting a hyperbolic attenuation trend. This trend indicates that the denudation rate in the Chengdu Longmenshan region is expected to return to the pre-seismic rate of 0.3 mm a-1 after 81 years. In 22 years after the earthquake (Year 2030), debris flow disasters are expected to be rare. (2) Disasters increased significantly in the Chengdu Longmenshan region after the Wenchuan earthquake, with an average of 29.5 people missing or dead per year (22 times greater than the pre-earthquake rate) and average economic losses of 192 million Yuan per year (1.6 times greater than the pre-earthquake rate). (3) The denudation process was jointly controlled by the quantities of loose solid material and precipitation after the Wenchuan earthquake. The amount of loose solid material influenced the extent of denudation, while vegetation coverage rates and soil consolidation determined the overall denudation trend in the region, and changes in precipitation led to denudation fluctuations. (4) The results can be used to analyze the relationship between the potential flash flood-debris flow disasters after earthquakes in the ancient Shu kingdom and changes in historical social settlements. The results can also be used to predict denudation processes and disaster risks from earthquakes in humid mountainous regions around the world, such as the southern

  3. The Chinese North Tianshan Orogen was a rear-arc (or back-arc) environment in the Late Carboniferous: constraint from the volcanic rocks in the Bogda Mountains

    Science.gov (United States)

    Xie, W.

    2017-12-01

    The Tianshan Orogen is a key area for understanding the Paleozoic tectonics and long-lasting evolution of the Central Asian Orogenic Belt (CAOB). However, considerable debate persists as to its tectonic setting during the late Paleozoic, with active subduction system and intraplate large igneous provinces as two dominant schools (Ma et al., 1997; Gu et al., 2000; Xiao et al., 2004; Han et al., 2010; Shu et al., 2011; Chen et al., 2011; Xia et al., 2012). With aims of providing constraints on this issue, petrology, mineralogy, geochronological and geochemistry for the Late Carboniferous volcanics from the Bogda Mountains have been carried out. We find two suits of high-Al basalt (HAB, 315-319 Ma) and a suit of submarine pillow basalt ( 311 Ma) in this region. Both of the two basalts belong to the tholeiitic magma (the tholeiitic index THI > 1) and contain low pre-eruptive magmatic H2O (coexisted with the Bogda HABs is I-type intermediate ignimbrites and rhyolite lavas. The rhyolites are formed by partial melting of a hydrated and juvenile arc crust and the ignimbrites are affected by magma mingling and feldspar fractionation (Xie et al., 2016c). The two basalts both have the MORB-like Sr-Nd-Hf-Pb isotopes and arc-like trace element compositions. We discuss that they may have been generated from a dry and depleted mantle source metasomatized by coexisted felsic volcanics were likely formed in a rear-arc or back-arc environment, probably related to southward subduction of the Paleo-Tianshan Ocean (Xie et al., 2016a, b, c).

  4. High infiltration of tumor-associated macrophages in triple-negative breast cancer is associated with a higher risk of distant metastasis

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    Yuan ZY

    2014-08-01

    Full Text Available Zhong-Yu Yuan,1–3* Rong-Zhen Luo,1,2,4,* Rou-Jun Peng,1–3 Shu-Sen Wang,1–3 Cong Xue1–3 1State Key Laboratory of Oncology in South China, 2Collaborative Innovation Center for Cancer Medicine, 3Departments of Medical Oncology, Sun Yat-Sen University Cancer Center, 4Departments of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, People’s Republic of China  *These authors contributed equally to this work Background: Triple-negative breast cancer (TNBC is associated with poor prognosis and high probability of distant metastases. Tumor microenvironments play a pivotal role in tumor metastasis. Tumor-associated macrophages (TAMs are one of the main cell components, and they are correlated with increasing metastatic risk. The aim of this study is to analyze the prognostic significance of the infiltration of TAMs in patients with TNBC. Materials and methods: Immunohistochemical staining for cluster of differentiation (CD68 (a marker for macrophages was performed on tissue microarrays of operable breast cancer among 287 patients with TNBC, and the number of infiltrating TAMs was correlated with clinicopathological parameters. Results: We found that TNBC with a large number of infiltrating TAMs had a significantly higher risk of distant metastasis, as well as lower rates of disease-free survival and overall survival than those with a smaller number of infiltrating TAMs. Multivariate analysis indicated that the number of infiltrating TAMs was a significant independent prognostic factor of disease-free survival (P=0.001 in all patients. Conclusion: Our results suggested that high infiltrating TAMs are a significantly unfavorable prognostic factor for patients with TNBC, and they could become a potentially useful prognostic marker for TNBC. Keywords: breast carcinoma, triple-negative, tumor-associated macrophages, prognosis

  5. Enhanced transdermal bioavailability of testosterone propionate via surfactant-modified ethosomes

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    Meng S

    2013-08-01

    Full Text Available Shu Meng,1 Zaixing Chen,2 Liqun Yang,1 Wei Zhang,1 Danhua Liu,1 Jing Guo,1 Yanmin Guan,1 Jianxin Li11Liaoning Research Institute of Family Planning, Shenyang, Liaoning Province, People's Republic of China; 2School of Pharmacy, China Medical University, Shenyang, Liaoning Province, People's Republic of ChinaAbstract: The current investigation aimed to evaluate the transdermal potential of novel testosterone propionate (TP ethosomes and liposomes prepared by surfactant modification. The effect of hexadecyl trimethyl ammonium bromide and cremophor EL-35 on the particle size and zeta potential of the prepared vesicles was investigated. The entrapment efficiency and stability, as well as in vitro and in vivo skin permeation, were studied with the various techniques, such as differential scanning calorimetry, confocal laser scanning microscopy, transmission electron microscopy, dynamic light scattering, and so on. The results indicated that the ethosomes were defined as spherical, unilamellar structures with low polydispersity (0.100 ± 0.015 and nanometric size (156.5 ± 3.5 nm. The entrapment efficiency of TP in ethosomal and liposomal carriers was 92.7% ± 3.7% and 64.7% ± 2.1%, respectively. The stability profile of the prepared TP ethosomal system assessed for 120 days revealed very low aggregation and very low growth in vesicular size. TP ethosomes also provided an enhanced transdermal flux of 37.85 ± 2.8 µg/cm2/hour and a decreased lag time of 0.18 hours across mouse skin. The skin permeation efficiency of the TP ethosomes as further assessed by confocal laser scanning microscopy revealed enhanced permeation of rhodamine red-loaded formulations to the deeper layers of the skin (260 µm than that of the liposomal formation (120 µm.Keywords: testosterone propionate, surfactant-modified ethosomes, liposomes, confocal laser scanning microscopy

  6. Human cytotoxic T-lymphocyte membrane-camouflaged nanoparticles combined with low-dose irradiation: a new approach to enhance drug targeting in gastric cancer

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    Zhang L

    2017-03-01

    Full Text Available Lianru Zhang, Rutian Li, Hong Chen, Jia Wei, Hanqing Qian, Shu Su, Jie Shao, Lifeng Wang, Xiaoping Qian, Baorui Liu The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing, People’s Republic of China Abstract: Cell membrane-derived nanoparticles are becoming more attractive because of their ability to mimic many features of their source cells. This study reports on a biomimetic delivery platform based on human cytotoxic T-lymphocyte membranes. In this system, the surface of poly-lactic-co-glycolic acid nanoparticles was camouflaged using T-lymphocyte membranes, and local low-dose irradiation (LDI was used as a chemoattractant for nanoparticle targeting. The T-lymphocyte membrane coating was verified using dynamic light scattering, transmission electron microscopy, and confocal laser scanning microscopy. This new platform reduced nanoparticle phagocytosis by macrophages to 23.99% (P=0.002. Systemic administration of paclitaxel-loaded T-lymphocyte membrane-coated nanoparticles inhibited the growth of human gastric cancer by 56.68% in Balb/c nude mice. Application of LDI at the tumor site significantly increased the tumor growth inhibition rate to 88.50%, and two mice achieved complete remission. Furthermore, LDI could upregulate the expression of adhesion molecules in tumor vessels, which is important in the process of leukocyte adhesion and might contribute to the localization of T-lymphocyte membrane-encapsulated nanoparticles in tumors. Therefore, this new drug-delivery platform retained both the long circulation time and tumor site accumulation ability of human cytotoxic T lymphocytes, while local LDI could significantly enhance tumor localization. Keywords: cell membrane, drug delivery system, gastric cancer, low-dose irradiation, nanoparticles

  7. Enhanced salt stress tolerance in transgenic potato plants expressing IbMYB1, a sweet potato transcription factor.

    Science.gov (United States)

    Cheng, Yu-Jie; Kim, Myoung-Duck; Deng, Xi-Ping; Kwak, Sang-Soo; Chen, Wei

    2013-12-01

    IbMYB1, a transcription factor (TF) for R2R3-type MYB TFs, is a key regulator of anthocyanin biosynthesis during storage of sweet potatoes. Anthocyanins provide important antioxidants of nutritional value to humans, and also protect plants from oxidative stress. This study aimed to increase transgenic potatoes' (Solanum tuberosum cv. LongShu No.3) tolerance to environmental stress and enhance their nutritional value. Transgenic potato plants expressing IbMYB1 genes under the control of an oxidative stress-inducible peroxidase (SWPA2) promoter (referred to as SM plants) were successfully generated through Agrobacterium-mediated transformation. Two representative transgenic SM5 and SM12 lines were evaluated for enhanced tolerance to salinity, UV-B rays, and drought conditions. Following treatment of 100 mM NaCl, seedlings of SM5 and SM12 lines showed less root damage and more shoot growth than control lines expressing only an empty vector. Transgenic potato plants in pots treated with 400 mM NaCl showed high amounts of secondary metabolites, including phenols, anthocyanins, and flavonoids, compared with control plants. After treatment of 400 mM NaCl, transgenic potato plants also showed high DDPH radical scavenging activity and high PS II photochemical efficiency compared with the control line. Furthermore, following treatment of NaCl, UV-B, and drought stress, the expression levels of IbMYB1 and several structural genes in the flavonoid biosynthesis such as CHS, DFR, and ANS in transgenic plants were found to be correlated with plant phenotype. The results suggest that enhanced IbMYB1 expression affects secondary metabolism, which leads to improved tolerance ability in transgenic potatoes.

  8. [Analysis of Therapeutic Regularities and Characteristics of Blood-letting Therapy for Acne Patients Based on Data Mining].

    Science.gov (United States)

    Du, Yu-zhu; Jia, Chun-sheng; Wang, Jian-ling; Shi, Jing; Zhang, Xiao-xu; Liu, Xin; Gang, Wei-juan

    2015-06-01

    To analyze the therapeutic regularities and characteristics of blood-letting therapy for acne in the past clinical practice by using data mining. Original papers about acne treated by pricking blood therapy were searched and screened from common databases as Chinese National Knowledge Infrastructure Database (CNKI), WanFang Data, SinoMed, Ovid, ScienceDirect, Socolar, SciFinder, Foreign Medical Journal Full-Text Service (FMJS) and PubMed using keywords of acne+bleeding therapy, acne+blood-letting, acne+ pricking blood, followed by establishing a data plateform to conduct a data mining using Online Analytical Processing (OLAP). A total of 230 original journal articles about acne treated by pricking blood therapy were collected. The included acne cases with wind-heat pattern were predoment, being 56 in frequency-times and acounting for 24. 78 %. In the treatment of acne, the therapeutic tool, three-edged needle was often used, being 168 in frequency and acounting for 71.79%. The frequently employed acupoints were those of the Governor Vessel and Bladder Meridian, such as Dazhui (GV 14) and back-shu points. When auricular points used for blood-letting, Erjian (EX-HN 6) and the Vena of the auricular back were most frequently selected. In addition to blood-letting, other therapies such as Chinese herbal medicines, filiform needles, and otopoint-pellet pressure were also used in combination, being 166 in items and constituting 72. 17%. Generally, blood-letting treatment was conducted once every three days (twice a week) or once every two days (three times a week) for about 20 sessions for each acne patient. Blood-letting therapy is effective in the treatment of acne. But if used in combination with other therapies, the therapeutic effect would be better.

  9. Social suffering and the culture of compassion in a morally divided China.

    Science.gov (United States)

    Kuah-Pearce, Khun Eng; Kleinman, Arthur; Harrison, Emily

    2014-01-01

    This collection of essays opens a critical examination of compassionate acts responding to social suffering in the intensely complex moral context of a rapidly changing and globalizing China. Jeanne Shea describes self-compassion among older women in China as a post-revolutionary response to changing opportunities and resistance to consumerism. Khun Eng Kuah-Pearce's essay frames the Buddhist organizations as NGOs and shows compassion being mobilized and its acts being spiritual-philanthropic, not political. The next three papers illuminate the complexity of mobility in a moral sea of changing values. Even as modernity facilitates movement of people away from suffering, the grinding of entangled moral experiences within the mobile group can be the cause of suffering. Shu-Min Huang critiques 'cultural petrification' as the diasporic Yunnan Chinese community in Thailand attempt to preserve the cultural forms and procedures of the world they left behind. Likewise, Richard Madsen shows that the idea of a universalized cultural heritage fails in the face of the 'micro-ecologies'. And yet the modern impulse to universalize beyond China has important implications for transnational compassion and cooperation. The work of the humanitarian organization Médecins Sans Frontières in China, discussed by Kuah-Pearce and Guiheux, challenges the universality of global humanitarian actions. Following the series of essays threaded across intersections of compassion, suffering, and a morally-divided China, the collection closes by looking at the West. Iain Wilkinson discusses the origins of social suffering as a focus of the social sciences, as well as the difficulties of making engaged compassion its task in a morally-divided world.

  10. Maximally efficient two-stage screening: Determining intellectual disability in Taiwanese military conscripts

    Directory of Open Access Journals (Sweden)

    Chia-Chang Chien

    2009-01-01

    Full Text Available Chia-Chang Chien1, Shu-Fen Huang1,2,3,4, For-Wey Lung1,2,3,41Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan; 2Graduate Institute of Behavioral Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan; 3Department of Psychiatry, National Defense Medical Center, Taipei, Taiwan; 4Calo Psychiatric Center, Pingtung County, TaiwanObjective: The purpose of this study was to apply a two-stage screening method for the large-scale intelligence screening of military conscripts.Methods: We collected 99 conscripted soldiers whose educational levels were senior high school level or lower to be the participants. Every participant was required to take the Wisconsin Card Sorting Test (WCST and the Wechsler Adult Intelligence Scale-Revised (WAIS-R assessments.Results: Logistic regression analysis showed the conceptual level responses (CLR index of the WCST was the most significant index for determining intellectual disability (ID; FIQ ≤ 84. We used the receiver operating characteristic curve to determine the optimum cut-off point of CLR. The optimum one cut-off point of CLR was 66; the two cut-off points were 49 and 66. Comparing the two-stage window screening with the two-stage positive screening, the area under the curve and the positive predictive value increased. Moreover, the cost of the two-stage window screening decreased by 59%.Conclusion: The two-stage window screening is more accurate and economical than the two-stage positive screening. Our results provide an example for the use of two-stage screening and the possibility of the WCST to replace WAIS-R in large-scale screenings for ID in the future.Keywords: intellectual disability, intelligence screening, two-stage positive screening, Wisconsin Card Sorting Test, Wechsler Adult Intelligence Scale-Revised

  11. Effects of a transmitted light device for pediatric peripheral venipuncture and intravenous cannulation

    Directory of Open Access Journals (Sweden)

    Yamazaki S

    2011-10-01

    Full Text Available Shinya Yamazaki1, Shu Tomita1, Masahiro Watanabe1, Hiroyoshi Kawaai1, Kazuhiro Shimamura2 1Department of Dental Anesthesiology; 2Department of Pediatric Dentistry, Ohu University Dental Hospital, Koriyama City, Fukushima Prefecture, Japan Abstract: Pediatric peripheral venipuncture and intravenous cannulation are difficult. However, successful venipuncture and intravenous cannulation are absolutely required for pediatric clinical risk management. This study assessed the success rate of venipuncture and intravenous cannulation when transmitted light was applied to the pediatric dorsum manus. The subjects included 100 young children who were scheduled for dental treatment or oral surgery under general anesthesia. Anesthesia was induced, and insertion of an intravenous catheter into the dorsum manus was attempted with or without using transmitted light. The patients were evaluated to determine whether the venipuncture was successful, and whether the intravenous cannulation of the external catheter was successful. The success rate of venipuncture was 100% when transmitted light was used, and 83% when the transmitted light was not used (P = 0.000016. In addition, the success rate of intravenous cannulation was 88% when transmitted light was used, and 55% when the transmitted light was not used (P = 0.0000002. The shape of the vein in the dorsum manus can be clearly recognized when transmitted light is used. The use of light significantly increased the success rate of intravenous cannulation, because it allowed direct confirmation of the direction to push the intravenous catheter forward. The use of transmitted light allows for more successful venipuncture and intravenous cannulation in young children. Keywords: transmitted light, pediatric peripheral venipuncture, pediatric peripheral intravenous cannulation

  12. Uranium of Kazakhstan

    International Nuclear Information System (INIS)

    Tsalyuk, Yu.; Gurevich, D.

    2000-01-01

    Over 25 % of the world's uranium reserves are concentrated in Kazakhstan. So, the world's largest Shu-Sarysu uranium province is situated on southern Kazakhstan, with resources exceeding 1 billion tonnes of uranium. No less, than 3 unique deposits with resources exceeding 100,000 tonnes are situated here. From the economic point of view the most important thing is that these deposits are suitable for in-situ leaching, which is the cheapest, environmentally friendly and most efficient method available for uranium extracting. In 1997 the Kazatomprom National Joint-Stock Company united all Kazakhstan's uranium enterprises (3 mine and concentrating plants, Volkovgeologiya Joint-Stock Company and the Ulbinskij Metallurgical plant). In 1998 uranium production came to 1,500 tonnes (860 kg in 1997). In 1999 investment to the industry were about $ 30 million. Plans for development of Kazakhstan's uranium industry provide a significant role for foreign partners. At present, 2 large companies (Comeco (Canada), Cogema (France) working in Kazakhstan. Kazakatomprom continues to attract foreign investors. The company's administration announced that in that in next year they have plan to make a radical step: to sell 67 % of stocks to strategic investors (at present 100 % of stocks belongs to state). Authors of the article regard, that the Kazakhstan's uranium industry still has significant reserves to develop. Even if the scenario for the uranium industry could be unfavorable, uranium production in Kazakhstan may triple within the next three to four years. The processing of uranium by the Ulbinskij Metallurgical Plant and the production of some by-products, such as rhenium, vanadium and rare-earth elements, may provide more profits. Obviously, the sale of uranium (as well as of any other reserves) cannot make Kazakhstan a prosperous country. However, country's uranium industry has a god chance to become one of the most important and advanced sectors of national economy

  13. Continued development of a portable widefield hyperspectral imaging (HSI) sensor for standoff detection of explosive, chemical, and narcotic residues

    Science.gov (United States)

    Nelson, Matthew P.; Gardner, Charles W.; Klueva, Oksana; Tomas, David

    2014-05-01

    Passive, standoff detection of chemical, explosive and narcotic threats employing widefield, shortwave infrared (SWIR) hyperspectral imaging (HSI) continues to gain acceptance in defense and security fields. A robust and user-friendly portable platform with such capabilities increases the effectiveness of locating and identifying threats while reducing risks to personnel. In 2013 ChemImage Sensor Systems (CISS) introduced Aperio, a handheld sensor, using real-time SWIR HSI for wide area surveillance and standoff detection of explosives, chemical threats, and narcotics. That SWIR HSI system employed a liquid-crystal tunable filter for real-time automated detection and display of threats. In these proceedings, we report on a next generation device called VeroVision™, which incorporates an improved optical design that enhances detection performance at greater standoff distances with increased sensitivity and detection speed. A tripod mounted sensor head unit (SHU) with an optional motorized pan-tilt unit (PTU) is available for precision pointing and sensor stabilization. This option supports longer standoff range applications which are often seen at checkpoint vehicle inspection where speed and precision is necessary. Basic software has been extended to include advanced algorithms providing multi-target display functionality, automatic threshold determination, and an automated detection recipe capability for expanding the library as new threats emerge. In these proceedings, we report on the improvements associated with the next generation portable widefield SWIR HSI sensor, VeroVision™. Test data collected during development are presented in this report which supports the targeted applications for use of VeroVision™ for screening residue and bulk levels of explosive and drugs on vehicles and personnel at checkpoints as well as various applications for other secure areas. Additionally, we highlight a forensic application of the technology for assisting forensic

  14. Codelivery of doxorubicin and triptolide with reduction-sensitive lipid–polymer hybrid nanoparticles for in vitro and in vivo synergistic cancer treatment

    Directory of Open Access Journals (Sweden)

    Wu B

    2017-03-01

    Full Text Available Bo Wu,1,2,* Shu-Ting Lu,1,* Liu-Jie Zhang,2 Ren-Xi Zhuo,2 Hai-Bo Xu,1 Shi-Wen Huang2 1Department of Radiology, Zhongnan Hospital of Wuhan University, 2Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, People’s Republic of China *These authors contributed equally to this work Abstract: Codelivery is a promising strategy to overcome the limitations of single chemotherapeutic agents in cancer treatment. Despite progress, codelivery of two or more different functional drugs to increase anticancer efficiency still remains a challenge. Here, reduction-sensitive lipid–polymer hybrid nanoparticles (LPNPs drug delivery system composed of monomethoxy-poly(ethylene glycol-S-S-hexadecyl (mPEG-S-S-C16, soybean lecithin, and poly(d,l-lactide-co-glycolide (PLGA was used for codelivery of doxorubicin (DOX and a Chinese herb extract triptolide (TPL. Hydrophobic DOX and TPL could be successfully loaded in LPNPs by self-assembly. More importantly, drug release and cellular uptake experiments demonstrated that the two drugs were reduction sensitive, released simultaneously from LPNPs, and taken up effectively by the tumor cells. DOX/TPL-coloaded LPNPs (DOX/TPL-LPNPs exhibited a high level of synergistic activation with low combination index (CI in vitro and in vivo. Moreover, the highest synergistic therapeutic effect was achieved at the ratio of 1:0.2 DOX/TPL. Further experiments showed that TPL enhanced the uptake of DOX by human oral cavity squamous cell carcinoma cells (KB cells. Overall, DOX/TPL-coencapsulated reduction-sensitive nanoparticles will be a promising strategy for cancer treatment. Keywords: triptolide, codelivery, reduction sensitive, synergistic effect

  15. Occurrence of chai hu (Bupleuri radix) in prescriptions of Chinese herbal medicine in Switzerland.

    Science.gov (United States)

    Klein, Sabine D; Becker, Simon; Wolf, Ursula

    2012-01-01

    Chai hu (Bupleuri radix), one of the most frequently used herbs in Chinese herbal medicine, has 3 major functions, depending on dosage and combination with other herbs. The aim of this study was to investigate how chai hu is prescribed in everyday practice in Switzerland, and whether these prescription patterns reflect its various applications. A random sample of 1,053 prescriptions was drawn from the database of Lian Chinaherb AG, Wollerau, Switzerland, and analyzed regarding the most frequently used classical formulas containing chai hu, daily dosages and combinations with other herbs. 29.0% of all prescriptions contained chai hu, and 98.0% of these were in granular form. The most frequently used classical formulas were xiao yao san ('rambling powder'), jia wei xiao yao san ('augmented rambling powder') and chai hu shu gan san ('Bupleurum powder to spread the liver'). In more than half of the prescriptions, chai hu was combined with bai shao (Paeoniae Radix Alba), dang gui (Angelicae sinensis radix) or fu ling (Poria). 51.8% of the prescriptions contained a low daily dosage of chai hu, 24.9% a medium and 15.1% a high dosage. Chai hu was generally prescribed in classic combinations with other herbs and in a medium dosage. Due to the addition of supplementary herbs to classical formulas, its daily dose was often diminished from a high or medium dose to a low dose. This raises the question if chai hu would then still exert its desired function of, e.g., moving liver-qi in these prescriptions.

  16. Characterization, pharmacokinetics, and hypoglycemic effect of berberine loaded solid lipid nanoparticles

    Directory of Open Access Journals (Sweden)

    Xue M

    2013-12-01

    Full Text Available Mei Xue, Ming-xing Yang, Wei Zhang, Xiu-min Li, De-hong Gao, Zhi-min Ou, Zhi-peng Li, Su-huan Liu, Xue-jun Li, Shu-yu Yang Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, People’s Republic of China Abstract: The high aqueous solubility, poor permeability, and absorption of berberine (BBR result in its low plasma level after oral administration, which greatly limits its clinical application. BBR solid lipid nanoparticles (SLNs were prepared to achieve improved bioavailability and prolonged effect. Developed SLNs showed homogeneous spherical shapes, small size (76.8 nm, zeta potential (7.87 mV, encapsulation efficiency (58%, and drug loading (4.2%. The power of X-ray diffraction combined with 1H nuclear magnetic resonance spectroscopy was employed to analyze chemical functional groups and the microstructure of BBR-SLNs, and indicated that the drug was wrapped in a lipid carrier. Single dose (50 mg/kg oral pharmacokinetic studies in rats showed significant improvement (P<0.05 in the peak plasma concentration, area under the curve, and variance of mean residence time of BBR-SLNs when compared to BBR alone (P<0.05, suggesting improved bioavailability. Furthermore, oral administration of both BBR and BBR-SLNs significantly suppressed body weight gain, fasting blood glucose levels, and homeostasis assessment of insulin resistance, and ameliorated impaired glucose tolerance and insulin tolerance in db/db diabetic mice. BBR-SLNs at high dose (100 mg/kg showed more potent effects when compared to an equivalent dose of BBR. Morphologic analysis demonstrated that BBR-SLNs potentially promoted islet function and protected the islet from regeneration. In conclusion, our study demonstrates that by entrapping BBR into SLNs the absorption of BBR and its anti-diabetic action were effectively enhanced. Keywords: berberine, solid lipid nanoparticles, pharmacokinetic, hypoglycemic effect

  17. α-MSH Influences the Excitability of Feeding-Related Neurons in the Hypothalamus and Dorsal Vagal Complex of Rats

    Directory of Open Access Journals (Sweden)

    Hong-Zai Guan

    2017-01-01

    Full Text Available Alpha-melanocyte-stimulating hormone (α-MSH is processed from proopiomelanocortin (POMC and acts on the melanocortin receptors, MC3 and MC4. α-MSH plays a key role in energy homeostasis. In the present study, to shed light on the mechanisms by which α-MSH exerts its anorectic effects, extracellular neuronal activity was recorded in the hypothalamus and the dorsal vagal complex (DVC of anesthetized rats. We examined the impact of α-MSH on glucose-sensing neurons and gastric distension (GD sensitive neurons. In the lateral hypothalamus (LHA, α-MSH inhibited 75.0% of the glucose-inhibited (GI neurons. In the ventromedial nucleus (VMN, most glucose-sensitive neurons were glucose-excited (GE neurons, which were mainly activated by α-MSH. In the paraventricular nucleus (PVN, α-MSH suppressed the majority of GI neurons and excited most GE neurons. In the DVC, among the 20 GI neurons examined for a response to α-MSH, 1 was activated, 16 were depressed, and 3 failed to respond. Nineteen of 24 GE neurons were activated by α-MSH administration. Additionally, among the 42 DVC neurons examined for responses to GD, 23 were excited (GD-EXC and 19 were inhibited (GD-INH. Fifteen of 20 GD-EXC neurons were excited, whereas 11 out of 14 GD-INH neurons were suppressed by α-MSH. All these responses were abolished by pretreatment with the MC3/4R antagonist, SHU9119. In conclusion, the activity of glucose-sensitive neurons and GD-sensitive neurons in the hypothalamus and DVC can be modulated by α-MSH.

  18. Low enrolment in Ugandan Community Health Insurance Schemes: underlying causes and policy implications

    Directory of Open Access Journals (Sweden)

    Criel Bart

    2007-07-01

    Full Text Available Abstract Background Despite the promotion of Community Health Insurance (CHI in Uganda in the second half of the 90's, mainly under the impetus of external aid organisations, overall membership has remained low. Today, some 30,000 persons are enrolled in about a dozen different schemes located in Central and Southern Uganda. Moreover, most of these schemes were created some 10 years ago but since then, only one or two new schemes have been launched. The dynamic of CHI has apparently come to a halt. Methods A case study evaluation was carried out on two selected CHI schemes: the Ishaka and the Save for Health Uganda (SHU schemes. The objective of this evaluation was to explore the reasons for the limited success of CHI. The evaluation involved review of the schemes' records, key informant interviews and exit polls with both insured and non-insured patients. Results Our research points to a series of not mutually exclusive explanations for this under-achievement at both the demand and the supply side of health care delivery. On the demand side, the following elements have been identified: lack of basic information on the scheme's design and operation, limited understanding of the principles underlying CHI, limited community involvement and lack of trust in the management of the schemes, and, last but not least, problems in people's ability to pay the insurance premiums. On the supply-side, we have identified the following explanations: limited interest and knowledge of health care providers and managers of CHI, and the absence of a coherent policy framework for the development of CHI. Conclusion The policy implications of this study refer to the need for the government to provide the necessary legislative, technical and regulative support to CHI development. The main policy challenge however is the need to reconcile the government of Uganda's interest in promoting CHI with the current policy of abolition of user fees in public facilities.

  19. The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells

    Directory of Open Access Journals (Sweden)

    Li JP

    2015-02-01

    Full Text Available Jin-Ping Li,1,2 Yin-Xue Yang,3 Qi-Lun Liu,1 Zhi-Wei Zhou,2,4 Shu-Ting Pan,2,5 Zhi-Xu He,4 Xueji Zhang,6 Tianxin Yang,7 Si-Yuan Pan,8 Wei Duan,9 Shu-Ming He,10 Xiao-Wu Chen,11 Jia-Xuan Qiu,5 Shu-Feng Zhou2,41Department of Surgical Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Department of Colorectal Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 4Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, Guizhou, People’s Republic of China; 5Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 6Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, People’s Republic of China; 7Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT, USA; 8Department of Pharmacology, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 9School of Medicine, Deakin University, Waurn Ponds, VIC, Australia; 10Department of Obstetrics and Gynecology, Xiaolan People’s Hospital affiliated to Southern Medical University, Zhongshan, Guangdong, People’s Republic of China; 11Department of General Surgery, The First People’s Hospital of Shunde affiliated to Southern Medical University, Shunde, Foshan, Guangdong, People’s Republic of China Abstract: Danusertib (Danu is a pan-inhibitor of Aurora kinases and a third-generation breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (Bcr-Abl tyrosine kinase inhibitor

  20. Was Pythagoras Chinese? An Examination of Right Triangle Theory in Ancient China. The Pennsylvania State University Studies No. 40.

    Science.gov (United States)

    Swetz, Frank J.; Kao, T. I.

    This book is primarily a scholarly monograph on ancient Chinese theory and application concerning the right triangle, based on evidence contained in classical mathematics texts and scrolls. It is also the first complete English translation of the ninth chapter of the Chiu chang suan chu, the richest source of problems from antiquity dealing with…

  1. Student Attitudes to Learning Business Statistics: Comparison of Online and Traditional Methods

    Science.gov (United States)

    Suanpang, Pannee; Petocz, Peter; Kalceff, Walter

    2004-01-01

    Worldwide, electronic learning (E-learning) has become an important part of the education agenda in the last decade. The Suan Dusit Rajabhat University (SDRU), Thailand has made significant efforts recently to use Internet technologies to enhance learning opportunities. The results reported here are part of a pioneering study to determine the…

  2. Implications of spinel compositions for the petrotectonic history of abyssal peridotite from Southwest Indian Ridge (SWIR)

    Science.gov (United States)

    Chen, T.; Jin, Z.; Wang, Y.; Tao, C.

    2012-12-01

    Abyssal peridotites generate at mid-ocean ridges. Lherzolite and harzburgite are the main rock types of peridotites in the uppermost mantle. The lherzolite subtype, less depleted and less common in ophiolites, characterizes mantle diapirs and slow-spreading ridges. Along the Earth's mid-ocean ridges, abyssal peridotites undergo hydration reactions to become serpentinite minerals, especially in slow to ultraslow spreading mid-ocean ridges. Spinel is common in small quantities in peridotites, and its compositions have often been used as petrogenetic indicators [1]. The Southwest Indian Ridge (SWIR) is one of the two ultraslow spreading ridges in the world. The studied serpentinized peridotite sample was collected by the 21st Voyage of the Chinese oceanic research ship Dayang Yihao (aka Ocean No. 1) from a hydrothermal field (63.5°E, 28.0°S, and 3660 m deep) in SWIR. The studied spinels in serpentinized lherzolite have four zones with different compositions: relic, unaltered core is magmatic Al-spinels; micro- to nano- sized ferrichromite zoned particles; narrow and discontinuous magnetite rim; and chlorite aureoles. The values Cr# of the primary Al-spinels indicate the range of melting for abyssal peridotites from SWIR extends from ~4% to ~7% [2]. The alteration rims of ferrichromite have a chemical composition characterized by Fe enrichment and Cr# increase indicating chromite altered under greenschist-amphibolite facies. Magnetites formed in syn- and post- serpentinization. Chlorite (clinochlore) formed at the boundary and crack of spinel indicating it had undergone with low-temperature MgO- and SiO2-rich hydrothermal fluids [3]. It suggests that serpentinized lherzolite from SWIR had undergone poly-stage hydration reactions with a wide range of temperature. Acknowledgments: EMPA experiment was carried out by Xihao Zhu and Shu Zheng in The Second Institute of Oceanography and China University of Geosciences, respectively. The work was supported by NSFC

  3. The Associations Among Individual Factors, eHealth Literacy, and Health-Promoting Lifestyles Among College Students.

    Science.gov (United States)

    Yang, Shu-Ching; Luo, Yi-Fang; Chiang, Chia-Hsun

    2017-01-10

    -promoting lifestyle. Moreover, this study showed that college students with a higher critical eHealth literacy engaged better in health-promoting activities than those with functional and interactive literacy. ©Shu-Ching Yang, Yi-Fang Luo, Chia-Hsun Chiang. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 10.01.2017.

  4. Engineered exosome-mediated delivery of functionally active miR-26a and its enhanced suppression effect in HepG2 cells

    Directory of Open Access Journals (Sweden)

    Liang G

    2018-01-01

    Full Text Available Gaofeng Liang,1,2,* Shu Kan,2,* Yanliang Zhu,3 Shuying Feng,1 Wenpo Feng,1 Shegan Gao1,4 1Medical College, Henan University of Science and Technology, Luoyang, China; 2Department of Biomedical Engineering, University of California Berkeley, California, CA, USA; 3State Key laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 4Henan Key Laboratory of Cancer Epigenetics, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China *These authors contributed equally to this work Introduction: Exosomes are closed-membrane nanovesicles that are secreted by a variety of cells and exist in most body fluids. Recent studies have demonstrated the potential of exosomes as natural vehicles that target delivery of functional small RNA and chemotherapeutics to diseased cells. Methods: In this study, we introduce a new approach for the targeted delivery of exosomes loaded with functional miR-26a to scavenger receptor class B type 1-expressing liver cancer cells. The tumor cell-targeting function of these engineered exosomes was introduced by expressing in 293T cell hosts, the gene fusion between the transmembrane protein of CD63 and a sequence from Apo-A1. The exosomes harvested from these 293T cells were loaded with miR-26a via electroporation. Results: The engineered exosomes were shown to bind selectively to HepG2 cells via the scavenger receptor class B type 1–Apo-A1 complex and then internalized by receptor-mediated endocytosis. The release of miR-26a in exosome-treated HepG2 cells upregulated miR-26a expression and decreased the rates of cell migration and proliferation. We also presented evidence that suggest cell growth was inhibited by miR-26a-mediated decreases in the amounts of key proteins that regulate the cell cycle. Conclusion: Our gene delivery strategy can be adapted to treat a broad spectrum of cancers by expressing proteins on the surface of mi

  5. Retrospective study of irinotecan/cisplatin followed by etoposide/cisplatin or the reverse sequence in extensive-stage small cell lung cancer

    Directory of Open Access Journals (Sweden)

    Xiao XG

    2015-08-01

    Full Text Available Xiaoguang Xiao, Shujing Wang, Shu Xia, Man Zou, Yang Li, Yao Wei, Qi Mei, Yuan Chen Department of Oncology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People’s Republic of China Background: Much research has confirmed the favorable effect of irinotecan/cisplatin (IP and etoposide/cisplatin (EP on extensive-stage small cell lung cancer (E-SCLC. This study investigated two sequential orders of IP and EP in the treatment of E-SCLC. We also compared the efficacy and safety of IP and EP in first-line chemotherapy in E-SCLC. Methods: Ninety-three untreated patients with E-SCLC were randomly allocated to two groups. Group A received IP as first-line therapy until progression and then changed to EP; group B received EP as first-line therapy until tumor progression followed by IP. The primary endpoints were overall survival and time to second tumor progression. The secondary endpoints were first progression-free survival (PFS, ie, time from randomization to first occurrence of tumor progression after first-line treatment with IP or EP, tumor response, and safety of the different sequential treatment orders of IP and EP. Results: Median overall survival was 15.4 months in group A (IP followed by EP versus 15.7 months in group B (EP followed by IP; P=0.483. The median time to second tumor progression was 9.5 months in group A versus 9.9 months in group B (P=0.361. As first-line and second-line therapy, IP achieved a 95.9% and 60% disease control rate, respectively, and EP achieved 95.6% and 59% disease control rate. The median first PFS was not significantly different between group A and group B (6.5 months and 6.3 months, respectively; P=0.256. Grade 3/4 diarrhea appeared to be significantly more frequent with IP than with EP. The probability of anemia and thrombocytopenia was not significantly different between the two groups. However, significantly more patients who received the IP regimen as

  6. Inter-alpha-trypsin inhibitor heavy chain 4: a novel biomarker for environmental exposure to particulate air pollution in patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Lee KY

    2015-04-01

    Full Text Available Kang-Yun Lee,1–3 Po-Hao Feng,1,2 Shu-Chuan Ho,4 Kai-Jen Chuang,5,6 Tzu-Tao Chen,2,3 Chien-Ling Su,2,4 Wen-Te Liu,2,4 Hsiao-Chi Chuang2,4 1Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, 2Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, 3Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, 4School of Respiratory Therapy, College of Medicine, Taipei Medical University, 5Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, 6School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan Abstract: Chronic obstructive pulmonary disease (COPD is a chronic inflammatory disease that is correlated with environmental stress. Particulate matter ≤10 µm (PM10 is considered to be a risk factor for COPD development; however, the effects of PM10 on the protein levels in COPD remain unclear. Fifty subjects with COPD and 15 healthy controls were recruited. Gene ontology analysis of differentially expressed proteins identified immune system process and binding as the most important biological process and molecular function, respectively, in the responses of PM10-exposed patients with COPD. Biomarkers for PM10 in COPD were identified and compared with the same in healthy controls and included proteoglycan 4 (PRG4, inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4, and apolipoprotein F (APOF. PRG4 and ITIH4 were associated with a past 3-year PM10 exposure level. The receiver operating characteristic curve analysis showed that ITIH4 is a sensitive and specific biomarker for PM10 exposure (area under the curve [AUC] =0.690, P=0.015 compared with PRG4 (AUC =0.636, P=0.083, APOF (AUC =0.523, P=0.766, 8-isoprostane (AUC =0.563, P=0.405, and C-reactive protein (CRP; AUC =0.634, P=0.086. ITIH4 levels were correlated with CRP (r=0

  7. Efficacy and safety of icotinib as first-line therapy in patients with advanced non-small-cell lung cancer

    Directory of Open Access Journals (Sweden)

    Shen YW

    2016-02-01

    Full Text Available Yan-Wei Shen,* Xiao-Man Zhang,* Shu-Ting Li, Meng Lv, Jiao Yang, Fan Wang, Zhe-Ling Chen, Bi-Yuan Wang, Pan Li, Ling Chen, Jin Yang Department of Medical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China *These authors contributed equally to this work Background and objective: Several clinical trials have proven that icotinib hydrochloride, a novel epidermal growth factor receptor (EGFR–tyrosine kinase inhibitor, exhibits encouraging efficacy and tolerability in patients with advanced non-small-cell lung cancer (NSCLC who failed previous chemotherapy. This study was performed to assess the efficacy and toxicity of icotinib as first-line therapy for patients with advanced pulmonary adenocarcinoma with EGFR-sensitive mutation.Patients and methods: Thirty-five patients with advanced NSCLC with EGFR-sensitive mutation who were sequentially admitted to the First Affiliated Hospital of Xi’an Jiaotong University from March 2012 to March 2014 were enrolled into our retrospective research. All patients were administered icotinib as first-line treatment. The tumor responses were evaluated using Response Evaluation Criteria in Solid Tumors (RECIST, version 1.1.Results: Among the 35 patients, the tumor objective response rate (ORR and disease control rate were 62.9% (22/35 and 88.6% (31/35, respectively. The median progression-free survival was 11.0 months (95% confidence interval [CI]: 10.2–11.8 months, and median overall survival was 21.0 months (95% CI: 20.1–21.9 months. The most common drug-related toxicities were rashes (eleven patients and diarrhea (nine patients, but these were generally manageable and reversible.Conclusion: Icotinib monotherapy is effective and tolerable as first-line treatment for patients with advanced lung adenocarcinoma with EGFR-sensitive mutation. Keywords: lung neoplasms, icotinib hydrochloride, first-line treatment

  8. Compound antimalarial ethosomal cataplasm: preparation, evaluation, and mechanism of penetration enhancement

    Directory of Open Access Journals (Sweden)

    Shen S

    2015-06-01

    Full Text Available Shuo Shen, Shu-Zhi Liu, Yu-Shi Zhang, Mao-Bo Du, Ai-Hua Liang, Li-Hua Song, Zu-Guang Ye Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China Abstract: Malaria is still a serious public health problem in some parts of the world. The problems of recurrence and drug resistance are increasingly more serious. Thus, it is necessary to develop a novel antimalarial agent. The objectives of this study were to construct a novel compound antimalarial transdermal nanosystem–ethosomal cataplasm, to investigate its characteristics and efficiency, and to systematically explore the penetration-enhancing mechanisms of ethosomal cataplasm. Artesunate-loaded ethosomes and febrifugine-loaded ethosomes were prepared, and their characteristics were evaluated. Drug-loaded ethosomes were incorporated in the matrix of cataplasm to form the compound antimalarial ethosomal cataplasm. With the help of ethosomal technology, the accumulated permeation quantity of artesunate significantly increased at 8 hours after administration, which was 1.57 times as much as that of conventional cataplasm. Soon after administration, the ethosomal cataplasm could make a large quantity of antimalarial drug quickly penetrate through skin, then the remaining drug in the ethosomal cataplasm could be steadily released. These characteristics of ethosomal cataplasm are favorable for antimalarial drugs to kill Plasmodium spp. quickly and prevent the resurgence of Plasmodium spp. As expected, the ethosomal cataplasm showed good antimalarial efficiency in this experiment. The negative conversion rates were 100% and the recurrence rates were 0% at all dosages. The mechanism of penetration enhancement of the ethosomal cataplasm was systematically explored using an optics microscope, polarization microscope, and transmission electron microscopy. The microstructure, ultrastructure, and birefringent structure in skin were observed. Data

  9. Expression of minichromosome maintenance genes in renal cell carcinoma

    Directory of Open Access Journals (Sweden)

    Zhong HB

    2017-11-01

    Full Text Available Hongbin Zhong,1,* Bin Chen,1,* Henrique Neves,2 Jinchun Xing,1 Youxin Ye,1 Ying Lin,1 Guohong Zhuang,3 Shu-Dong Zhang,4 Jiyi Huang,1,5 Hang Fai Kwok2 1Xiang’an Branch, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, People’s Republic of China; 2Faculty of Health Sciences, University of Macau, Taipa, Macau SAR; 3Medical College of Xiamen University, Xiamen, Fujian, People’s Republic of China; 4Northern Ireland Centre for Stratified Medicine, Biomedical Sciences Research Institute, Ulster University, Londonderry, UK; 5The First Clinical School of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China *These authors contributed equally to this work Abstract: Minichromosome maintenance (MCM proteins play an essential role in DNA replication. They have been shown to be overexpressed in various types of cancer. However, the role of this family in renal cell carcinoma (RCC is widely unknown. In this study, we have identified a number of RCC datasets in the Gene Expression Omnibus database and also investigated the correlation between the expression levels of MCM genes and clinicopathological parameters. We found that the expression levels of MCM genes are positively correlated with one another. Expression levels of MCM2, MCM5, MCM6, and MCM7, but not of MCM3 and MCM4, were higher in RCC compared to paired adjacent normal tissue. Only the expression level of MCM4, but not of other MCMs, was positively correlated with tumor grade. In addition, a high-level expression of MCM2 in either primary tumor or metastases of RCC predicted a shorter disease-free survival time, while a high-level expression of MCM4 or MCM6 in primary tumor was also associated with poorer disease-free survival. Interestingly, we also demonstrated that patients with their primary RCC overexpressing 2 or more MCM genes had a shorter disease-free survival time, while those with RCC metastases overexpressing 3 or more MCM genes had a shorter

  10. Hyaluronic acid–nimesulide conjugates as anticancer drugs against CD44-overexpressing HT-29 colorectal cancer in vitro and in vivo

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    Jian YS

    2017-03-01

    Full Text Available You-Sin Jian,1 Ching-Wen Chen,1 Chih-An Lin,2 Hsiu-Ping Yu,1 Hua-Yang Lin,3 Ming-Yuan Liao,1 Shu-Huan Wu,1 Yan-Fu Lin,1 Ping-Shan Lai1,2,4,5 1Department of Chemistry, 2PhD Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, Taichung, 3Preclinical Development Research Department, Holy Stone Healthcare Co., Ltd., Taipei, 4Research Center for Sustainable Energy and Nanotechnology, 5Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan Abstract: Carrier-mediated drug delivery systems are promising therapeutics for targeted delivery and improved efficacy and safety of potent cytotoxic drugs. Nimesulide is a multifactorial cyclooxygenase 2 nonsteroidal anti-inflammatory drug with analgesic, antipyretic and potent anticancer properties; however, the low solubility of nimesulide limits its applications. Drugs conjugated with hyaluronic acid (HA are innovative carrier-mediated drug delivery systems characterized by CD44-mediated endocytosis of HA and intracellular drug release. In this study, hydrophobic nimesulide was conjugated to HA of two different molecular weights (360 kDa as HA with high molecular weight [HAH] and 43kDa as HA with low molecular weight [HAL] to improve its tumor-targeting ability and hydrophilicity. Our results showed that hydrogenated nimesulide (N-[4-amino-2-phenoxyphenyl]methanesulfonamide was successfully conjugated with both HA types by carbodiimide coupling and the degree of substitution of nimesulide was 1%, which was characterized by 1H nuclear magnetic resonance 400 MHz and total correlation spectroscopy. Both Alexa Fluor® 647 labeled HAH and HAL could selectively accumulate in CD44-overexpressing HT-29 colorectal tumor area in vivo, as observed by in vivo imaging system. In the in vitro cytotoxic test, HA–nimesulide conjugate displayed >46% cell killing ability at a nimesulide concentration of 400 µM in HT-29 cells, whereas

  11. [Flying needling therapy combined with clomiphene for ovulation failure in polycystic ovary syndrome:a randomized controlled trial].

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    Ma, Hong; Quan, Xiaohong; Chen, Xiuhua; Dong, Ying

    2016-11-12

    To compare the efficacy among the combined treatment of flying needling therapy and clomiphene, the simple application of flying needling therapy and simple clomiphene in the treatment of ovulation failure in polycystic ovary syndrome (PCOS). Ninety patients of PCOS were randomized into a flying needling therapy group, a medication group and a combined treatment group, 30 cases in each one. In the flying needling therapy group, the flying needling therapy was simply applied to Ganshu (BL 18), Shenshu (BL 23), Zhongwan (CV 12), Shuifen (CV 9), Guanyuan (CV 4) and Zhongji (CV 3). The unilateral back- shu points were used alternatively in each treatment. The needles were inserted rapidly with rotation technique and even-needling manipulation. The needles were retained for 30 min. The treatment was given once every two days, 3 times a week. In the medication group, clomiphene was taken orally on the 5th day of menstruation, continuously for 5 days. In the combined treatment group, the flying needling therapy and clomiphene were used in combination. All of the patients were treated for 3 months and followed up for 1 month. The ovulation rates were compared among the three groups. The levels of androgen testosterone were compared before and after treatment. In the combined treatment group, the ovulation rate was 86.2% (100/116), better than 66.7% (80/120) in the flying needling therapy group and 69.6% (78/112) in the medication group (both P medication group ( P >0.05). After treatment, the level of testosterone was reduced in the three groups (all P medication group (both P medication group ( P >0.05). The adverse reactions in the combined treatment group and the flying needling therapy group were lower than those in the medication group (both P <0.05). The flying needling therapy effectively improves in the ovulation failure of PCOS and its effect is similar to clomiphene. The allied treatment of them apparently improves the clinical efficacy and alleviates the adverse

  12. Prognostic factors for survival among patients with primary bone sarcomas of small bones

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    Wang Z

    2018-05-01

    Full Text Available Zhan Wang,1,* Shu Li,2,* Yong Li,1 Nong Lin,1 Xin Huang,1 Meng Liu,1 Weibo Pan,1 Xiaobo Yan,1 Lingling Sun,1 Hengyuan, Li,1 Binghao Li,1 Hao Qu,1 Yan Wu,1 Peng Lin,1 Zhaoming Ye1 1Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Centre for Orthopaedic Research, Orthopedics Research Institute of Zhejiang University, Hangzhou, China; 2Key Laboratory of Cancer Prevention and Intervention, Key Laboratory of Molecular Biology in Medical Sciences, National Ministry of Education, Department of Hematology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Cancer Institute, Hangzhou, China *These authors contributed equally to this work Background: Primary bone sarcomas of the hands or feet are rare lesions and poorly documented. Moreover, the prognostic determinants of bone sarcomas of the hands or feet have not been reported. Materials and methods: The Surveillance, Epidemiology, and End Results (SEER program database was used to screen patients with bone sarcomas of the hands or feet from 1973 to 2013, with attention paid to chondrosarcoma, Ewing sarcoma, and osteosarcoma. The prognostic values of overall survival (OS and cancer-specific survival (CSS were assessed using Cox proportional hazards regression model with univariate and multivariate analyses. The Kaplan–Meier method was used to obtain OS and CSS curves. Results: A total of 457 cases were selected from the SEER database. Chondrosarcoma was the most common form of lesion in hands or feet or both, followed by Ewing sarcoma and osteosarcoma. The 5- and 10-year OS rates of the entire group were 75.7% and 66.1%, respectively. The 5- and 10-year CSS rates were 78.7% and 73.7%, respectively. Multivariate analysis revealed that age under 40 years, localized stage, low grade, surgical treatment, and first primary tumor were associated with improved OS, and decade of diagnosis, stage, grade, and surgery were independent

  13. Synergistic anti-glioma effect of a coloaded nano-drug delivery system

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    Xu H

    2016-12-01

    Full Text Available Huae Xu,1,* Feng Jia,2,* Pankaj Kumar Singh,3 Shu Ruan,4 Hao Zhang,5,* Xiaolin Li5 1Department of Pharmacy, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 2Department of Neurosurgery, Yancheng City No 1 People’s Hospital, The Fourth Affiliated Hospital of Nantong Medical College, Yancheng, People’s Republic of China; 3Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 4Department of Endocrinology, Yancheng Third Hospital, The Affiliated Hospital of Southeast University Medical College, Yancheng, 5Department of Geriatrics, The First Affiliated Hospital with Nanjing Medical University, Nanjing, People’s Republic of China *These authors contributed equally to this work Abstract: The anti-glioma effect of temozolomide (Tem is sometimes undermined by the emerging resistance. Recently, resveratrol (Res, herbal medicine extracted from grape seeds, has been demonstrated for its potential use in chemosensitization. In the current study, both these drugs were loaded simultaneously into nanoparticles with methoxy poly(ethylene glycol-poly epsilon caprolactone (mPEG-PCL as drug carriers in order to achieve better antitumor efficiency. Tem/Res-coloaded mPEG-PCL nanoparticles were constructed, characterized, and tested for antitumor effect on glioma cells by using in vitro and xenograft model system. The nanoparticle constructs were satisfactory with drug loading content (Res =~12.4%; Tem =~9.3% and encapsulation capacity of >85% for both the drugs. In addition, the coencapsulation led to better in vitro stability of the nanoparticles than Tem-loaded nanoparticles. An in vitro uptake study demonstrated a high uptake efficiency of the nanoparticles by glioma cells. The synergistic antitumor effect against glioma cells was observed in the combinational treatment of Res and Tem. Tem/Res-coloaded nanoparticles induced higher apoptosis in U87 glioma cells as

  14. Comparative Analysis of Fruit Metabolites and Pungency Candidate Genes Expression between Bhut Jolokia and Other Capsicum Species.

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    Sarpras M

    Full Text Available Bhut jolokia, commonly known as Ghost chili, a native Capsicum species found in North East India was recorded as the naturally occurring hottest chili in the world by the Guinness Book of World Records in 2006. Although few studies have reported variation in pungency content of this particular species, no study till date has reported detailed expression analysis of candidate genes involved in capsaicinoids (pungency biosynthesis pathway and other fruit metabolites. Therefore, the present study was designed to evaluate the diversity of fruit morphology, fruiting habit, capsaicinoids and other metabolite contents in 136 different genotypes mainly collected from North East India. Significant intra and inter-specific variations for fruit morphological traits, fruiting habits and 65 fruit metabolites were observed in the collected Capsicum germplasm belonging to three Capsicum species i.e., Capsicum chinense (Bhut jolokia, 63 accessions, C. frutescens (17 accessions and C. annuum (56 accessions. The pungency level, measured in Scoville Heat Unit (SHU and antioxidant activity measured by 2, 2-diphenyl-1-picrylhydrazyl (DPPH free radical scavenging assay showed maximum levels in C. chinense accessions followed by C. frutescens accessions, while C. annuum accessions showed the lowest value for both the traits. The number of different fruit metabolites detected did not vary significantly among the different species but the metabolite such as benzoic acid hydroxyl esters identified in large percentage in majority of C. annuum genotypes was totally absent in the C. chinense genotypes and sparingly present in few genotypes of C. frutescens. Significant correlations were observed between fruit metabolites capsaicin, dihydrocapsaicin, hexadecanoic acid, cyclopentane, α-tocopherol and antioxidant activity. Furthermore, comparative expression analysis (through qRT-PCR of candidate genes involved in capsaicinoid biosynthesis pathway revealed many fold higher

  15. The Density-wave Theory and Spiral Structures by Looking at Spiral Arms through a Multi-wavelength StudyHamed Pour-Imani1,2, Daniel Kennefick1,2, Julia Kennefick1,2, Mohamed Shameer Abdeen1,2, Eric Monson1,2, Douglas W. Shields1,2, B. L. Davis31Department of Physics, University of Arkansas, Fayetteville, AR 72701, USA2Arkansas Center for Space & Planetary Sciences, Univ. of Arkans

    Science.gov (United States)

    Pour-Imani, Hamed; Kennefick, Daniel; Kennefick, Julia; Shameer Abdeen, Mohammad; Monson, Erick; Shields, Douglas William; Davis, Benjamin L.

    2018-01-01

    The density-wave theory of spiral structure, though first proposed as long ago as the mid-1960s by C.C. Lin and F. Shu, continues to be challenged by rival theories, such as the manifold theory. One test between these theories which has been proposed is that the pitch angle of spiral arms for galaxies should vary with the wavelength of the image in the density-wave theory, but not in the manifold theory. The reason is that stars are born in the density wave but move out of it as they age. In this study, we combined large sample size with a wide range of wavelengths to investigate this issue. For each galaxy, we used wavelength FUV151nm, U-band, H-alpha, optical wavelength B-band and infrared 3.6 and 8.0μm. We measured the pitch angle with the 2DFFT and Spirality codes (Davis et al. 2012; Shields et al. 2015). We find that the B-band and 3.6μm images have smaller pitch angles than the infrared 8.0μm image in all cases, in agreement with the prediction of the density-wave theory. We also find that the pitch angle at FUV and H-alpha are close to the measurements made at 8.0μm. The Far-ultraviolet wavelength at 151nm shows very young, very bright UV stars still in the star-forming region (they are so bright as to be visible there and so short-lived that they never move out of it). We find that for both sets of measurements (2dFFT and Spirality) the 8.0μm, H-alpha and ultraviolet images agree in their pitch angle measurements, suggesting that they are, in fact, sensitive to the same region. By contrast, the 3.6μm and B-band images are uniformly tighter in pitch angle measurements than these wavelengths, suggesting that the density-wave picture is correct.

  16. Health care provider experience with canagliflozin in real-world clinical practice: favorability, treatment patterns, and patient outcomes

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    Bolge SC

    2017-06-01

    Full Text Available Susan C Bolge,1 Natalia M Flores,2 Shu Huang,3 Jennifer Cai1 1Janssen Scientific Affairs, LLC, Titusville, NJ, 2Kantar Health, Foster City, CA, 3Kantar Health, New York, NY, USA Purpose: This study describes how health care providers approach canagliflozin for the treatment of patients with type 2 diabetes mellitus (T2DM in the real world.Patients and methods: An Internet-based questionnaire was completed by 101 endocrinologists, 101 primary care physicians, and 100 nurse practitioners/physician assistants (NP/PAs. Health care providers were required to have experience prescribing or managing patients using canagliflozin to be included in the study. Health care providers compared canagliflozin with other T2DM medication classes on clinical characteristics, costs, and patient satisfaction. Confidence in canagliflozin was also measured. Health care providers reported their canagliflozin prescribing experience and good candidate characteristics for treatment. Finally, providers reported on patient outcomes among those receiving canagliflozin. All variables were compared across provider type.Results: Health care providers reported higher favorability for canagliflozin for blood pressure and body weight compared with dipeptidyl peptidase-4 (DPP-4 inhibitors and higher favorability for effect on blood pressure, body weight, treatment satisfaction, and glycosylated hemoglobin (HbA1c compared with sulfonylureas (SUs, with differences observed for effect on blood pressure. Health care providers reported being very/extremely confident (55%–74% with canagliflozin as a second- to fourth-line treatment. The top 3 characteristics reported by the providers, in terms of describing a good candidate for canagliflozin, include those concerned about their weight, insurance coverage/affordability, and avoiding injectable treatments. Finally, providers reported often/always observing patients’ lowering or controlling HbA1c (82%–88% and improvement in overall

  17. Tracking multidecadal trends in sea level using coral microatolls

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    Majewski, Jedrzej; Pham, Dat; Meltzner, Aron; Switzer, Adam; Horton, Benjamin; Heng, Shu Yun; Warrick, David

    2015-04-01

    Tracking multidecadal trends in sea level using coral microatolls Jędrzej M. Majewski 1, Dat T. Pham1, Aron J. Meltzner 1, Adam D. Switzer 1, Benjamin P. Horton2, Shu Yun Heng1, David Warrick3, 1 Earth Observatory of Singapore, Nanyang Technological University, Singapore 2 Department of Marine and Coastal Sciences, Rutgers University, New Brunswick, NJ, USA 3 Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA, USA Coral microatolls can be used to study relative sea-level change at multidecadal timescales associated with vertical land movements, climate induced sea-level rise and other oceanographic phenomena such as the El Niño/Southern Oscillation (ENSO) or Indian Ocean Dipole (IOD) with the assumption that the highest level of survival (HLS) of coral microatolls track sea level over the course of their lifetimes. In this study we compare microatoll records covering from as early as 1883 through 2013, from two sites in Indonesia, with long records (>20 years) from proximal tide gauges, satellite altimetry, and other sea-level reconstructions. We compared the HLS time series derived from open-ocean and moated (or ponded) microatolls on tectonically stable Belitung Island and a potentially tectonically active setting in Mapur Island, with sea-level reconstructions for 1950-2011. The sea-level reconstructions are based on ground and satellite measurements, combining a tide model with the Estimating the Circulation and Climate of the Ocean (ECCO) model. Our results confirm that open-ocean microatolls do track low water levels at multi decadal time scales and can be used as a proxy for relative sea level (RSL) over time. However, microatolls that are even partially moated are unsuitable and do not track RSL; rather, their growth patterns likely reflect changes in the elevation of the sill of the local pond, as reported by earlier authors. Our ongoing efforts will include an attempt to recognize similarities in moated

  18. Effects of the Ambient Fine Particulate Matter on Public Awareness of Lung Cancer Risk in China: Evidence from the Internet-Based Big Data Platform.

    Science.gov (United States)

    Yang, Hongxi; Li, Shu; Sun, Li; Zhang, Xinyu; Hou, Jie; Wang, Yaogang

    2017-10-03

    the association of PM 2.5 with lung cancer risk, to lead the public to seek more information about PM 2.5 and its hazards, and to cope with their environment and its risks appropriately. ©Hongxi Yang, Shu Li, Li Sun, Xinyu Zhang, Jie Hou, Yaogang Wang. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 03.10.2017.

  19. Manipulation of Schwann cell migration across the astrocyte boundary by polysialyltransferase-loaded superparamagnetic nanoparticles under magnetic field

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    Xia B

    2016-12-01

    Full Text Available Bing Xia,* Liangliang Huang,* Lei Zhu, Zhongyang Liu, Teng Ma, Shu Zhu, Jinghui Huang, Zhuojing Luo Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, People’s Republic of China *These authors contributed equally to this work Abstract: Schwann cell (SC transplantation is an attractive strategy for spinal cord injury (SCI. However, the efficacy of SC transplantation has been limited by the poor migratory ability of SCs in the astrocyte-rich central nervous system (CNS environment and the inability to intermingle with the host astrocyte. In this study, we first magnetofected SCs by polysialyltransferase-functionalized superparamagnetic iron oxide nanoparticles (PST/SPIONs to induce overexpression of polysialylation of neural cell adhesion molecule (PSA-NCAM to enhance SC migration ability, before manipulating the direction of SC migration with the assistance of an applied magnetic field (MF. It was found that magnetofection with PST/SPIONs significantly upregulated the expression of PSA-NCAM in SCs, which significantly enhanced the migration ability of SCs, but without preferential direction in the absence of MF. The number and averaged maximum distance of SCs with PST/SPIONs migrating into the astrocyte domain were significantly enhanced by an applied MF. In a 300 µm row along the astrocyte boundary, the number of SCs with PST/SPIONs migrating into the astrocyte domain under an MF was 2.95 and 6.71 times higher than that in the absence of MF and the intact control SCs, respectively. More interestingly, a confrontation assay demonstrated that SCs with PST/SPIONs were in close contact with astrocytes and no longer formed boundaries in the presence of MF. In conclusion, SCs with PST/SPIONs showed enhanced preferential migration along the axis of a magnetic force, which might be beneficial for the formation of Büngner bands in the CNS. These findings raise the possibilities of enhancing the

  20. Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling

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    Kanwar JR

    2015-06-01

    Full Text Available Jagat R Kanwar,1 Rasika M Samarasinghe,1 Kuldeep Kumar,2 Ramesh Arya,2 Sanjeev Sharma,2 Shu-Feng Zhou,3 Sreenivasan Sasidharan,4 Rupinder K Kanwar11Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research (NLIMBR, School of Medicine (SoM, Molecular and Medical Research (MMR Strategic Research Centre, Faculty of Health, Geelong Technology Precinct (GTP, Deakin University, Waurn Ponds, VIC, Australia; 2Ayurvedic College, Paprola, Kangra, Himachal Pradesh, India; 3Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA; 4Institute for Research in Molecular Medicine (INFORMM, Universiti Sains Malaysia, Penang, MalaysiaIntroduction: Inflammatory mediators are key players in the pathogenesis of osteoarthritis (OA and bone destruction. Conventional drugs suppress symptomatic activity and have no therapeutic influence on disease. Cissus quadrangularis and Withania somnifera are widely used for the treatment of bone fractures and wounds; however, the cellular and molecular mechanisms regulated by these herbals are still unclear.Methods: We established an in vitro OA culture model by exposing human chondrocytes to proinflammatory cytokine and interleukin (IL-1β for 36 hours prior to treatment with the herbals: C. quadrangularis, W. somnifera, and the combination of the two herbals. Cell viability, toxicity, and gene expression of OA modifying agents were examined. In addition, expression of survivin, which is crucial for cell growth, was analyzed. In vivo work on osteotomized rats studied the bone and cartilage regenerative effects of C. quadrangularis, W. somnifera, and the combination therapy.Results: Exposure of chondrocytes to IL-1β induced significant toxicity and cell death. However, herbal treatment alleviated IL-1β induced cell toxicity and upregulated cell growth and proliferation. C. quadrangularis inhibited gene expression of cytokines and matrix metalloproteinases, known to

  1. PÚRPURA TROMBOCITOPÉNICA TROMBÓTICA: DIAGNÓSTICO DIFERENCIAL CON EL SÍNDROME HEMOLÍTICO URÉMICO. PRESENTACIÓN DE UN CASO

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    Parra Velasco Pedro

    2016-07-01

    Full Text Available La púrpura trombocitopénica trombótica (PTT pertenece a las microangiopatías trombóticas (MAT; un grupo de enfermedades caracterizadas por la presencia de anemia hemolítica microangiopática, trombocitopenia y trombosis microvascular. Ésta última característica, es causante de isquemia que puede manifestarse a diferentes niveles tales como el riñón y sistema nervioso central. Las MAT incluyen varias patologías dentro de las cuales se destacan además de la PTT, el síndrome hemolítico urémico (SHU y el síndrome hemolítico urémico atípico (SHUa, cuyas alteraciones fisiopatológicas difieren de acuerdo a la enfermedad. La pentada clásica de la PTT describe trombocitopenia, anemia hemolítica microangiopática, fiebre, síntomas neurológicos y falla renal. A pesar de que en la PTT la afectación neurológica es más frecuente que la disfunción renal, los síntomas pueden solaparse entre las 3 enfermedades, dificultando un diagnóstico preciso. Es por ello que en la actualidad se observa más casos de PTT con manifestaciones atípicas, como lo son la disfunción renal como manifestación principal, en ausencia de sintomatología neurológica. Esto ha llevado a que las pruebas moleculares se vuelvan imprescindibles para un diagnóstico preciso. A continuación, se describe el caso de un paciente con PTT y déficit severo de ADAMTS 13, quien debutó con disfunción renal, sin afectación neurológica, respondiendo al tratamiento con plasmaferesis. Palabras Clave: Púrpura trombocitopénica trombótica, síndrome hemolítico urémico, anemia hemolítica.

  2. Identification of differentially expressed genes and signaling pathways in ovarian cancer by integrated bioinformatics analysis

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    Yang X

    2018-03-01

    Full Text Available Xiao Yang,1 Shaoming Zhu,2 Li Li,3 Li Zhang,1 Shu Xian,1 Yanqing Wang,1 Yanxiang Cheng1 1Department of Obstetrics and Gynecology, 2Department of Urology, Renmin Hospital of Wuhan University, 3Department of Pharmacology, Wuhan University Health Science Center, Wuhan, Hubei, People’s Republic of China Background: The mortality rate associated with ovarian cancer ranks the highest among gynecological malignancies. However, the cause and underlying molecular events of ovarian cancer are not clear. Here, we applied integrated bioinformatics to identify key pathogenic genes involved in ovarian cancer and reveal potential molecular mechanisms. Results: The expression profiles of GDS3592, GSE54388, and GSE66957 were downloaded from the Gene Expression Omnibus (GEO database, which contained 115 samples, including 85 cases of ovarian cancer samples and 30 cases of normal ovarian samples. The three microarray datasets were integrated to obtain differentially expressed genes (DEGs and were deeply analyzed by bioinformatics methods. The gene ontology (GO and Kyoto Encyclopedia of Genes and Genomes (KEGG pathway enrichments of DEGs were performed by DAVID and KOBAS online analyses, respectively. The protein–protein interaction (PPI networks of the DEGs were constructed from the STRING database. A total of 190 DEGs were identified in the three GEO datasets, of which 99 genes were upregulated and 91 genes were downregulated. GO analysis showed that the biological functions of DEGs focused primarily on regulating cell proliferation, adhesion, and differentiation and intracellular signal cascades. The main cellular components include cell membranes, exosomes, the cytoskeleton, and the extracellular matrix. The molecular functions include growth factor activity, protein kinase regulation, DNA binding, and oxygen transport activity. KEGG pathway analysis showed that these DEGs were mainly involved in the Wnt signaling pathway, amino acid metabolism, and the

  3. Effects of acupuncture on peripheral T lymphocyte subpopulation and amounts of cerebral catecholamines in mice.

    Science.gov (United States)

    Okumura, M; Toriizuka, K; Iijima, K; Haruyama, K; Ishino, S; Cyong, J C

    1999-01-01

    The aim of this study was to investigate the effects of acupuncture on peripheral lymphocyte subpopulations and cerebral catecholamines. In order to examine the effects of acupuncture, two experiments were performed. Experiment 1: Eighteen female mice (strain; C57BL/6) at the age of 7 weeks were divided three groups, (a) sham operated (control; n=6), (b) ovariectomized (OVX; n=6), and (c) ovariectomized and stimulated by subcutaneous needles on acupuncture point, Shenshu (BL23) at the both sides of the back for 20 days (OVX+Acu; n=6). These animals were sacrificed at 20 days after needle insertion, and the splenic lymphoid cells were examined by two-color flow cytometry, using monoclonal antibodies (mAb) to the cell surface antigens, CD3, CD4, CD8a and NK1.1 (CD56). In the ovariectomized (OVX) group, the peripheral CD4/CD8 ratio was significantly increased and the ratio of natural killer (NK) cells (CD3-NK1.1+; CD3 negative, NK1.1 positive) to T lymphocytes was decreased compared to the sham control group. In the ovariectomized with needle insertion (OVX+Acu) group, the CD4/CD8 ratio was reduced, but the NK cells ratio was not changed compared to the OVX group. Experiment 2: To investigate the acute effects of subcutaneous needle insertion, male C57BL/6 mice (7 weeks old) were used (n=6, each group). The acupuncture points Shen-shu (BL23) on the backs of the male mice were also stimulated by subcutaneous needles for 3 and 7 days. As a result, the CD4/CD8 ratio was significantly decreased at day 3 and day 7, compared to the control group. On the other hand the NK cells ratio and activated T-cells were increased at day 7. The mitogenic activities in the splenic lymphocytes were also increased by acupuncture stimulation at day 3. Catecholamine contents in the hippocampus were measured by high performance liquid chromatography with the electro-chemical detector (ECD-HPLC) method. No significant change was observed in either dopamine contents or norepinephrine; however

  4. Mesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts

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    Zhu Y

    2014-12-01

    Full Text Available Yin Zhu,1,* Ming Cheng,2,* Zhen Yang,3 Chun-Yan Zeng,3 Jiang Chen,3 Yong Xie,3 Shi-Wen Luo,3 Kun-He Zhang,3 Shu-Feng Zhou,4 Nong-Hua Lu1,31Department of Gastroenterology, 2Department of Orthopedics, 3Institute of Digestive Disease, The First Affiliated Hospital of Nanchang University, Jiangxi, People’s Republic of China; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA*These authors contributed equally to this workAbstract: Mesenchymal stem cells (MSCs have been recognized as promising delivery vehicles for gene therapy of tumors. Gastric cancer is the third leading cause of worldwide cancer mortality, and novel treatment modalities are urgently needed. NK4 is an antagonist of hepatocyte growth factor receptors (Met which are often aberrantly activated in gastric cancer and thus represent a useful candidate for targeted therapies. This study investigated MSC-delivered NK4 gene therapy in nude mice bearing gastric cancer xenografts. MSCs were transduced with lentiviral vectors carrying NK4 complementary DNA or enhanced green fluorescent protein (GFP. Such transduction did not change the phenotype of MSCs. Gastric cancer xenografts were established in BALB/C nude mice, and the mice were treated with phosphate-buffered saline (PBS, MSCs-GFP, Lenti-NK4, or MSCs-NK4. The tropism of MSCs toward gastric cancer cells was determined by an in vitro migration assay using MKN45 cells, GES-1 cells and human fibroblasts and their presence in tumor xenografts. Tumor growth, tumor cell apoptosis and intratumoral microvessel density of tumor tissue were measured in nude mice bearing gastric cancer xenografts treated with PBS, MSCs-GFP, Lenti-NK4, or MSCs-NK4 via tail vein injection. The results showed that MSCs migrated preferably to gastric cancer cells in vitro. Systemic MSCs-NK4 injection significantly suppressed the growth of gastric cancer xenografts. MSCs-NK4 migrated and accumulated in tumor

  5. Screening of potential diagnostic markers and therapeutic targets against colorectal cancer

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    Tian XQ

    2015-07-01

    Full Text Available XiaoQing Tian, DanFeng Sun, ShuLiang Zhao, Hua Xiong, JingYuan Fang Department of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Jiao Tong University, Shanghai, People’s Republic of China Objective: To identify genes with aberrant promoter methylation for developing novel diagnostic markers and therapeutic targets against primary colorectal cancer (CRC. Methods: Two paired CRC and adjacent normal tissues were collected from two CRC patients. A Resi: MBD2b protein-sepharose-4B column was used to enrich the methylated DNA fragments. Difference in the average methylation level of each DNA methylation region between the tumor and control samples was determined by log2 fold change (FC in each patient to screen the differentially methylated DNA regions. Genes with log2FC value ≥4 or ≤-4 were identified to be hypermethylated and hypomethylated, respectively. Then, the underlying functions of methylated genes were speculated by Gene Ontology database and pathway enrichment analyses. Furthermore, a protein–protein interaction network was built using Search Tool for the Retrieval of Interacting Genes/Proteins database, and the transcription factor binding sites were screened via the Encyclopedia of DNA Elements (ENCODE database. Results: Totally, 2,284 and 1,142 genes were predicted to have aberrant promoter hypermethylation or hypomethylation, respectively. MAP3K5, MAP3K8, MAPK14, and MAPK9 with promoter hypermethylation functioned via MAPK signaling pathway, focal adhesion, or Wnt signaling pathway, whereas MAP2K1, MAPK3, MAPK11, and MAPK7 with promoter hypomethylation functioned via TGF-beta signaling pathway, neurotrophin signaling pathway, and chemokine signaling pathway. CREBBP, PIK3R1, MAPK14, APP, ESR1, MAPK3, and HRAS were the seven hubs in the constructed protein–protein interaction network. RPL22, RPL36, RPLP2, RPS7, and RPS9 were commonly regulated by

  6. Effects of HGF gene polymorphisms and protein expression on transhepatic arterial chemotherapeutic embolism efficacy and prognosis in patients with primary liver cancer

    Directory of Open Access Journals (Sweden)

    Chen HY

    2017-02-01

    Full Text Available Hai-Yong Chen,1,2 Yao-Min Chen,3 Jian Wu,1,2 Fu-Chun Yang,1,2 Zhen Lv,1,2 Yi-Gang Qian,1,2 Shu-Sen Zheng1,2 1Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, 2Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 3Department of Breast Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China Objective: To investigate the correlations of two hepatocyte growth factor (HGF gene polymorphisms (rs5745652 and rs2074725 and their protein expression levels with the efficacy of transhepatic arterial chemotherapeutic embolism (TACE and prognosis in patients with primary liver cancer (PLC. Methods: From March 2011 to June 2012, 109 PLC patients (the case group who chose TACE as primary treatment and 80 healthy people (the control group who had undergone physical examination in The First Affiliated Hospital, Zhejiang University were selected during the same period. Gene polymorphisms of HGF rs5745652 and HGF rs2074725 were detected. Serum HGF level, treating efficacy, survival quality, and 3-year survival rate for PLC patients who received TACE were observed. Results: There were significant differences in genotype and allele frequencies of HGF rs5745652 and HGF rs2074725, between the case and control groups (all P<0.05. Compared with CT+TT genotype of HGF rs5745652, patients carrying CC genotype had lower serum HGF levels, higher efficacy, better survival quality, and prolonged 3-year survival rate (all P<0.05. In rs2074725, patients carrying CA+AA genotype had lower serum HGF levels, higher efficacy, better survival quality, and prolonged 3-year survival rate compared with patients carrying rs2074725 CC genotype (all P<0.05. Gene polymorphisms of HGF rs5745652 and HGF rs2074725, tumor size, and Barcelona Clinic Liver Cancer stage were independent prognostic factors for PLC (P<0.05. Conclusion: Our

  7. Overexpression of ETV4 protein in triple-negative breast cancer is associated with a higher risk of distant metastasis

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    Yuan ZY

    2014-09-01

    Full Text Available Zhong-Yu Yuan,1–3,* Ting Dai,1,2,* Shu-Sen Wang,1–3 Rou-Jun Peng,1–3 Xing-Hua Li,1,2 Tao Qin,1–3 Li-Bing Song,1,2 Xi Wang1,2,41State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China; 2Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China; 3Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China; 4Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China  *These authors contributed equally to this work Background: Patients with triple-negative breast cancer (TNBC present a higher probability of distant metastasis and lack of effective targeted therapy. ETS translocation variant 4 (ETV4 is an ETS (E-26 transcription factor and has been associated with tumor metastasis. However, the clinical and functional significance of ETV4 in TNBC still remains unclear. Methods: A human tumor metastasis polymerase chain reaction array was used to profile differential expression of tumor metastasis-related genes in TNBC tissue. Real-time reverse transcription and Western blot analyses were performed to verify ETV4 expression in TNBC cells and tissue. Immunohistochemistry was used to detect expression of ETV4 protein in 135 TNBC tissue samples for association between ETV4 protein expression and clinical outcomes. Results: A total total of eight upregulated (CCL7, KISS1, MET, MMP7, NR4A3, ETV4, TIMP3, and TSHR and three downregulated (ITGA7, SSTR, and MMP2 genes were identified between TNBC tissue and the luminal subtype of breast cancer tissue. ETV4 messenger ribonucleic acid was more than five-fold upregulated in TNBC tissue compared with the control tissue. ETV4 overexpression was found in 57.0% of 135 TNBC cases. Overexpression of ETV4 protein was associated with an advanced stage and a higher proportion of positive lymph node and lymphovascular invasion. Patients with an ETV4

  8. Consolidation chemotherapy improves progression-free survival in stage III small-cell lung cancer following concurrent chemoradiotherapy: a retrospective study

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    Chen XR

    2016-09-01

    Full Text Available Xin-Ru Chen,1,* Jian-Zhong Liang,2,* Shu-Xiang Ma,1 Wen-Feng Fang,1 Ning-Ning Zhou,1 Hai Liao,1 De-Lan Li,1 Li-Kun Chen1 1Department of Medical Oncology, 2Department of Pathology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China *These authors contributed equally to this work Background: Concurrent chemoradiotherapy (CCRT is the standard treatment for limited-stage small-cell lung cancer (LD-SCLC. However, the efficacy of consolidation chemotherapy (CCT in LD-SCLC remains controversial despite several studies that were performed in the early years of CCT use. The aim of this study was to reevaluate the effectiveness and toxicities associated with CCT. Methods: This retrospective analysis evaluated 177 patients with stage IIIA and IIIB small-cell lung cancer (SCLC who underwent CCRT from January 2001 to December 2013 at Sun Yat-Sen University Cancer Center (SYSUCC. Overall survival (OS and progression-free survival (PFS were analyzed using Kaplan–Meier methods. Univariate and multivariate analyses were performed to analyze patient prognosis factors. Results: Among the 177 patients, 72 (41% received CCT and 105 (59% did not receive CCT. PFS was significantly better for patients in the CCT group compared to that for patients in the non-CCT group (median PFS: 17.0 vs 12.9 months, respectively, P=0.031, whereas the differences in OS were not statistically significant (median OS: 31.6 vs 24.8 months, respectively, P=0.118. The 3- and 5-year OS rates were 33.3% and 20.8% for patients in the CCT group and 27.6% and 6.7% for patients in the non-CCT group, respectively. Multivariate analysis revealed that having a pretreatment carcinoembryonic antigen level <5 ng/mL (P=0.035, having undergone prophylactic cranial irradiation (P<0.001, and having received CCT (P=0.002 could serve as favorable independent prognostic factors

  9. Evolution of Electronic Cigarette Brands From 2013-2014 to 2016-2017: Analysis of Brand Websites.

    Science.gov (United States)

    Hsu, Greta; Sun, Jessica Y; Zhu, Shu-Hong

    2018-03-12

    The electronic cigarette (e-cigarette) industry has grown in size and organizational complexity in recent years, most notably with the entry of major tobacco companies in 2012 and the proliferation of vape shops. Many brands maintain retail websites that present e-cigarette marketing claims and sell directly to consumers. Understanding of the evolving composition of different types of e-cigarette brand websites is currently underdeveloped. This paper presents how e-cigarette brand websites surveyed in 2013-2014 evolved by 2016-2017, and how the websites run by different types of e-cigarette producers currently differ. In 2016-2017, we revisited 466 e-cigarette brand websites surveyed in 2013-2014, 288 of which were extant, and identified 145 new English-language websites. We compared product designs, marketing claims, and age-based warnings presented by types of e-cigarette producers: major tobacco companies, independent vape shops, and independent internet-only companies. Among the 433 websites examined in 2016-2017, 12 were owned by major tobacco companies, 162 operated a physical vape shop, and 259 were internet-only operations. Closed-system product designs were sold by 83% (10/12) of tobacco-owned brands. In comparison, 29.0% (47/162, Ptraditional combustible cigarette flavors of tobacco and menthol (P values e-liquid compared with internet-only and vape shop brands (P values e-cigarettes as healthier (Pe-cigarette brands has not appeared to increase since 2014, even as website messaging evolved, with brands owned by tobacco companies and vape shops pulling in opposite directions. Brands owned by tobacco companies offered a limited range of e-cigarette products, whereas brands owned by vape shops emphasized a panoply of flavor and nicotine options. Furthermore, the Food and Drug Administration's regulatory action may influence the types of e-cigarette products offered and the market shares of various companies. ©Greta Hsu, Jessica Y Sun, Shu-Hong Zhu

  10. Stellar Dynamics

    Science.gov (United States)

    Binney, James

    Gröninger was dissatisfied with his approximate treatment of (141) since it gave poor estimates of the fundamental lines in the waterstuff spectrum. We have even less reason to be satisfied with the Lin-Shu-Kalnajs analysis of (140) which, unaided, is unable to give an adequate account of even the high-frequency normal modes; Personne's programme turns out to involve loosely-wound waves for which the LsK-dispersion relation is not really valid. Obviously more powerful techniques need to be developed for the solution of (140). Meanwhile, is the TWA theory of spiral structure worth bothering with? Quantitatively the TWA theory is not a success. Yet it has played an important role in the study of galaxies by introducing a widely employed conceptual framework. Only after effective machinery for the evaluation of normal modes of disks is available will we know for certain whether this role has been beneficial. In any event one must not underestimate the con- and de-structuve influence on progress in science of the conceptual frameworks that simple models introduce. Two examples will illustrate this point: (i) High-energy physicists think always in terms of particles and interactions and yet these are really just elements (propagators and vertices) introduced during the iterative solution of a set of coupled non-linear integro-differential equations. (ii) Isaac Newton spent vastly more time, thought and experimental effort on chemistry than on either physics or mathematics. Yet his incomparable mind, which both before and after his period as a chemist revolutionized mathematics and first demonstrated the possibility of exact science, achieved nothing of lasting value in Chemistry, whose foundations were to be laid by men of much smaller stature in the mid 18thc. Why did he fail so miserably? Because his conceptual framework was pre-Newtonian; brought up in the mystical, pre-Enlightenment mid 17thc. he thought in terms of the ancient alchemical concepts of corruption and

  11. The efficiency and safety of trastuzumab and lapatinib added to neoadjuvant chemotherapy in Her2-positive breast cancer patients: a randomized meta-analysis

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    Chen ZL

    2016-05-01

    Full Text Available Zhe-Ling Chen, Yan-Wei Shen, Shu-Ting Li, Chun-Li Li, Ling-Xiao Zhang, Jiao Yang, Meng Lv, Ya-Yun Lin, Xin Wang, Jin Yang Department of Medical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China Background: The addition of human epidermal growth factor receptor 2 (Her2 therapies to neoadjuvant chemotherapy (NAC during treatment of Her2-positive breast cancer has been proposed as an effective way to improve the prognosis. However, the treatment outcomes of adding trastuzumab, lapatinib, or both to NAC were not unequivocal in randomized clinical trials. Based on these data, a meta-analysis was performed. Objective: The main objective was to evaluate the efficiency and safety of trastuzumab and lapatinib added to NAC for treatment of Her2-positive breast cancer. Methods: ClinicalTrials.gov and PubMed were searched for randomized clinical trials that compared trastuzumab, lapatinib, or both, added to NAC. The main endpoint was a pathologically complete response (pCR rate, in breast only or in breast and lymph nodes. The drug safety and the influence of hormone-receptor status, comparing the clinical response and the rate of breast conservation, were evaluated. Results: A total of eight publications were included in the primary analysis, designed as two or three subgroups. The cumulative cases were 2,349 and the analyses of all the clinical trials showed that the pCR rate was significantly higher in the group receiving trastuzumab than that in the group with lapatinib, either in breast only (P=0.001 or in breast and lymph nodes (P=0.0001. Similar results could be seen in comparisons of the combination versus trastuzumab group. Further studies of subgroups divided into hormone receptor-positive or-negative patients showed that the addition of trastuzumab or dual Her2-targeted therapy significantly improved the pCR rate in patients who were hormone-insensitive. Regarding the toxic

  12. Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro

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    Huang T

    2015-04-01

    Full Text Available Tonglie Huang,1,* Kuo Zhang,2,* Lijuan Sun,3 Xiaochang Xue,1 Cun Zhang,1 Zhen Shu,1 Nan Mu,1 Jintao Gu,1 Wangqian Zhang,1 Yukun Wang,1 Yingqi Zhang,1 Wei Zhang1 1State Key Laboratory of Cancer Biology, Department of Biopharmaceutics, School of Pharmacy, The Fourth Military Medical University, 2National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, 3Department of Ophthalmology, Xijing Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China *These authors contributed equally to this work Abstract: Chemical burns take up a high proportion of burns admissions and can penetrate deep into tissues. Various reagents have been applied in the treatment of skin chemical burns; however, no optimal reagent for skin chemical burns currently exists. The present study investigated the effect of topical body protective compound (BPC-157 treatment on skin wound healing, using an alkali burn rat model. Topical treatment with BPC-157 was shown to accelerate wound closure following an alkali burn. Histological examination of skin sections with hematoxylin–eosin and Masson staining showed better granulation tissue formation, reepithelialization, dermal remodeling, and a higher extent of collagen deposition when compared to the model control group on the 18th day postwounding. BPC-157 could promote vascular endothelial growth factor expression in wounded skin tissues. Furthermore, 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide and cell cycle analysis demonstrated that BPC-157 enhanced the proliferation of human umbilical vein endothelial cells (HUVECs. Transwell assay and wound healing assay showed that BPC-157 significantly promoted migration of HUVECs. We also observed that BPC-157 upregulated the expression of VEGF-a and accelerated vascular tube formation in vitro. Moreover, further studies suggested that BPC-157 regulated the phosphorylation level of

  13. Prolyl carboxypeptidase in Agouti-related Peptide neurons modulates food intake and body weight

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    Giuseppe Bruschetta

    2018-04-01

    Full Text Available Objective: Prolyl carboxypeptidase (PRCP plays a role in the regulation of energy metabolism by inactivating hypothalamic α-melanocyte stimulating hormone (α-MSH levels. Although detected in the arcuate nucleus, limited PRCP expression has been observed in the arcuate POMC neurons, and its site of action in regulating metabolism is still ill-defined. Methods: We performed immunostaining to assess the localization of PRCP in arcuate Neuropeptide Y/Agouti-related Peptide (NPY/AgRP neurons. Hypothalamic explants were then used to assess the intracellular localization of PRCP and its release at the synaptic levels. Finally, we generated a mouse model to assess the role of PRCP in NPY/AgRP neurons of the arcuate nucleus in the regulation of metabolism. Results: Here we show that PRCP is expressed in NPY/AgRP-expressing neurons of the arcuate nucleus. In hypothalamic explants, stimulation by ghrelin increased PRCP concentration in the medium and decreased PRCP content in synaptic extract, suggesting that PRCP is released at the synaptic level. In support of this, hypothalamic explants from mice with selective deletion of PRCP in AgRP neurons (PrcpAgRPKO showed reduced ghrelin-induced PRCP concentration in the medium compared to controls mice. Furthermore, male PrcpAgRPKO mice had decreased body weight and fat mass compared to controls. However, this phenotype was sex-specific as female PrcpAgRPKO mice show metabolic differences only when challenged by high fat diet feeding. The improved metabolism of PrcpAgRPKO mice was associated with reduced food intake and increased energy expenditure, locomotor activity, and hypothalamic α-MSH levels. Administration of SHU9119, a potent melanocortin receptor antagonist, selectively in the PVN of PrcpAgRPKO male mice increased food intake to a level similar to that of control mice. Conclusions: Altogether, our data indicate that PRCP is released at the synaptic levels and that PRCP in AgRP neurons contributes to

  14. The hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability

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    Zhang L

    2018-03-01

    Full Text Available Li Zhang,1,2,* Mengxi Liu,1,* Chaocheng Lu,1 Dandan Ren,1 Guoqing Fan,1 Chang Liu,1 Mengjiao Liu,1 Gang Shu,1 Guangneng Peng,1 Zhixiang Yuan,1 Zhijun Zhong,1 Wei Zhang,1 Hualin Fu1 1Department of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China; 2Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan Academy of Chinese Medicine Sciences, Chengdu, Sichuan, China *These authors contributed equally to this work Introduction: Toltrazuril (Tol is used to prevent and combat coccidiosis. However, its low aqueous solubility and poor oral bioavailability limit clinical application. Methods: To overcome the shortcomings, toltrazuril–hydroxypropyl–β-cyclodextrin inclusion complex (Tol-HP-β-CD was prepared and characterized. The comparative plasma disposition kinetics of Tol was analyzed after a single orally administered dose of 10 mg/kg Tol or Tol-HP-β-CD in rabbits. Solution-stirring method was selected to prepare the inclusion complex. Complex formation was characterized by thin-layer chromatography, Fourier transform infrared spectrophotometry, and 1H nuclear magnetic resonance spectroscopy. In plasma profile, plasma samples were collected between 1 and 10 days following administration. Plasma Tol concentrations were determined by high-performance liquid chromatography. Results: In rabbit plasma, the time to peak concentration (Tmax of Tol-HP-β-CD was shorter than that of Tol (12 h vs 24 h. Cmax (19.92±1.02 µg/mL and area under the concentration–time curve (AUC0-∞, 1,176.86±70.26 mg/L h of the Tol-HP-β-CD group significantly increased (p<0.01 than those of the Tol group (Cmax, 8.02±1.04 µg/mL; AUC0-∞, 514.03±66.65 mg/L h. Conclusion: It can be concluded that the Tol-HP-β-CD increased the aqueous solubility and enhanced the oral bioavailability in rabbits. Complexation with HP-β-CD is a feasible way to prepare a rapidly absorbed and more bioavailable Tol

  15. An improved weighted essentially non-oscillatory scheme for hyperbolic conservation laws

    Science.gov (United States)

    Borges, Rafael; Carmona, Monique; Costa, Bruno; Don, Wai Sun

    2008-03-01

    In this article we develop an improved version of the classical fifth-order weighted essentially non-oscillatory finite difference scheme of [G.S. Jiang, C.W. Shu, Efficient implementation of weighted ENO schemes, J. Comput. Phys. 126 (1996) 202-228] (WENO-JS) for hyperbolic conservation laws. Through the novel use of a linear combination of the low order smoothness indicators already present in the framework of WENO-JS, a new smoothness indicator of higher order is devised and new non-oscillatory weights are built, providing a new WENO scheme (WENO-Z) with less dissipation and higher resolution than the classical WENO. This new scheme generates solutions that are sharp as the ones of the mapped WENO scheme (WENO-M) of Henrick et al. [A.K. Henrick, T.D. Aslam, J.M. Powers, Mapped weighted essentially non-oscillatory schemes: achieving optimal order near critical points, J. Comput. Phys. 207 (2005) 542-567], however with a 25% reduction in CPU costs, since no mapping is necessary. We also provide a detailed analysis of the convergence of the WENO-Z scheme at critical points of smooth solutions and show that the solution enhancements of WENO-Z and WENO-M at problems with shocks comes from their ability to assign substantially larger weights to discontinuous stencils than the WENO-JS scheme, not from their superior order of convergence at critical points. Numerical solutions of the linear advection of discontinuous functions and nonlinear hyperbolic conservation laws as the one dimensional Euler equations with Riemann initial value problems, the Mach 3 shock-density wave interaction and the blastwave problems are compared with the ones generated by the WENO-JS and WENO-M schemes. The good performance of the WENO-Z scheme is also demonstrated in the simulation of two dimensional problems as the shock-vortex interaction and a Mach 4.46 Richtmyer-Meshkov Instability (RMI) modeled via the two dimensional Euler equations.

  16. Kinematic modeling of the Milky Way using the RAVE and GCS stellar surveys

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, S.; Bland-Hawthorn, J. [Sydney Institute for Astronomy, School of Physics, University of Sydney, Sydney, NSW 2006 (Australia); Binney, J. [Rudolf Peierls Center for Theoretical Physics, University of Oxford, 1 Keble Road, Oxford OX1 3NP (United Kingdom); Freeman, K. C. [RSAA Australian National University, Mount Stromlo Observatory, Cotter Road, Weston Creek, Canberra, ACT 72611 (Australia); Steinmetz, M.; Williams, M. E. K. [Leibniz Institut für Astrophysik Potsdam (AIP), An der Sterwarte 16, D-14482 Potsdam (Germany); Boeche, C.; Grebel, E. K. [Astronomisches Rechen-Institut, Zentrum für Astronomie der Universität Heidelberg, D-69120 Heidelberg (Germany); Bienaymé, O.; Siebert, A. [Observatoire astronomique de Strasbourg, Université de Strasbourg, CNRS, UMR 7550, F-67000 Strasbourg (France); Gibson, B. K. [Jeremiah Horrocks Institute for Astrophysics and Super-computing, University of Central Lancashire, Preston PR1 2HE (United Kingdom); Gilmore, G. F.; Kordopatis, G. [Institute of Astronomy, University of Cambridge, Madingley Road, Cambridge CB3 0HA (United Kingdom); Helmi, A. [Kapteyn Astronomical Institute, University of Groningen, Postbus 800, 9700 AV Groningen (Netherlands); Munari, U. [INAF-Astronomical Observatory of Padova, I-36012 Asiago (VI) (Italy); Navarro, J. F. [University of Victoria, P.O. Box 3055, Station CSC, Victoria, BC V8W 3P6 (Canada); Parker, Q. A.; Reid, W. A. [Department of Physics and Astronomy, Macquarie University, Sydney, NSW 2109 (Australia); Seabroke, G. M. [Mullard Space Science Laboratory, University College London, Holmbury St Mary, Dorking RH5 6NT (United Kingdom); Watson, F. [Australian Astronomical Observatory, P.O. Box 296, Epping, NSW 1710 (Australia); and others

    2014-09-20

    We investigate the kinematic parameters of the Milky Way disk using the Radial Velocity Experiment (RAVE) and Geneva-Copenhagen Survey (GCS) stellar surveys. We do this by fitting a kinematic model to the data and taking the selection function of the data into account. For stars in the GCS we use all phase-space coordinates, but for RAVE stars we use only (ℓ, b, v {sub los}). Using the Markov Chain Monte Carlo technique, we investigate the full posterior distributions of the parameters given the data. We investigate the age-velocity dispersion relation for the three kinematic components (σ {sub R}, σ{sub φ}, σ {sub z}), the radial dependence of the velocity dispersions, the solar peculiar motion (U {sub ☉}, V {sub ☉}, W {sub ☉}), the circular speed Θ{sub 0} at the Sun, and the fall of mean azimuthal motion with height above the midplane. We confirm that the Besançon-style Gaussian model accurately fits the GCS data but fails to match the details of the more spatially extended RAVE survey. In particular, the Shu distribution function (DF) handles noncircular orbits more accurately and provides a better fit to the kinematic data. The Gaussian DF not only fits the data poorly but systematically underestimates the fall of velocity dispersion with radius. The radial scale length of the velocity dispersion profile of the thick disk was found to be smaller than that of the thin disk. We find that correlations exist between a number of parameters, which highlights the importance of doing joint fits. The large size of the RAVE survey allows us to get precise values for most parameters. However, large systematic uncertainties remain, especially in V {sub ☉} and Θ{sub 0}. We find that, for an extended sample of stars, Θ{sub 0} is underestimated by as much as 10% if the vertical dependence of the mean azimuthal motion is neglected. Using a simple model for vertical dependence of kinematics, we find that it is possible to match the Sgr A* proper motion without

  17. Are symbols useful and culturally acceptable in health-state valuation studies? An exploratory study in a multi-ethnic Asian population

    Directory of Open Access Journals (Sweden)

    Hwee-Lin

    2008-10-01

    Full Text Available Hwee-Lin, Wee1, Shu-Chuen Li2, Xu-Hao Zhang1, Feng Xie3, David Feeny4, Nan Luo5, Yin-Bun Cheung6, David Machin7, Kok-Yong Fong8, Julian Thumboo81Department of Pharmacy, National University of Singapore (NUS, Singapore; 2Discipline of Pharmacy and Experimental Pharmacology, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Newcastle, NSW, Australia; 3McMaster University, Hamilton, Ontario, Canada; 4Kaiser Permanente Northwest Center for Health Research, Portland, OR, USA; 5Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, NUS, Singapore; 6Clinical Trials and Epidemiology Research Unit, Singapore; 7School of Health and Related Research, University of Sheffield, Sheffield, UK; 8Department of Rheumatology and Immunology, Singapore General Hospital, SingaporeBackground: Symbols have been used in health state valuation studies to help subjects distinguish the severity of various characteristics of a given health state. Symbols used in such studies need to be evaluated for their cross-cultural appropriateness because a given symbol may have different meanings or acceptability in different cultures, which may affect results of such studies.Objectives: To evaluate if using symbols to differentiate health states of different severity is useful and culturally acceptable in a multi-ethnic, urban Asian population.Methods: Using in-depth interviews with adult Chinese, Malay, and Indian Singaporeans conducted in English/mother-tongue, subjects were shown a health state with 6 levels (Health Utilities Index 3 vision, each displayed with a symbol, and asked (1a if symbols were useful in differentiating severity of each level (measured using dichotomous and 0–10 visual analog scale [VAS] scales or (1b offensive and (2 to assess 7 alternative sets of symbols.Results: Of 63 subjects (91% response rate, 18 (29% felt symbols were useful in differentiating severity of each level. Reported usefulness

  18. SOIL ALGAE OF BLADE OF COIL IN DONETSK REGION

    Directory of Open Access Journals (Sweden)

    Maltseva I.A.

    2011-12-01

    Full Text Available On territory of Donbass for more than 200 years the underground coal mining has produced, accompanied by the formation of the mine dumps. Finding ways to reduce their negative impact on the environment should be based on their comprehensive study. The soil algae are active participants in the syngenetic processes in industrial dumps of different origin. The purpose of this paper is to identify the species composition and dominant algae groups in dump mine SH/U5 “Western” in the western part of Donetsk.The test blade is covered with vegetation to the middle from all sides, and on the north side of 20-25 m to the top. The vegetation cover of the lower and middle tiers of all the exposures range in 70-80%. Projective vegetation cover of upper tiers of the northern, north-eastern and north-western exposures are in the range of 20-40%, other – 5-10%. We revealed some 38 algae species as a result of our research in southern, northern, western, and eastern slopes of the blade “Western”. The highest species diversity has Chlorophyta - 14 species (36.8% of the total number of species, then Cyanophyta - 9 (23,7%, Bacillariophyta - 7 (18,4%, Xantophyta - 5 (13.2%, and Eustigmatophyta - 3 (7.9%. The dominants are represented by Hantzschia amphyoxys (Ehrenberg Grunow in Cleve et Grunow, Bracteacoccus aerius, Klebsormidium flaccidum (Kützing Silva et al., Phormidium autumnale, Pinnularia borealis Ehrenberg, Planothidium lanceolatum (Brebisson in Kützing Bukhtiyarova, Xanthonema exile (Klebs Silva.It should be noted that the species composition of algae groups in different slopes of the blade was significantly different. Jacquard coefficient was calculated for algae communities varied in the range of 15,4-39,1%. The smallest number of algae species was observed on the southern slope of the blade (14 species, maximum was registered in the areas of north and west slopes. Differences in the species composition of algae were also observed in three

  19. Oleanolic acid induces mitochondrial-dependent apoptosis and G0/G1 phase arrest in gallbladder cancer cells

    Directory of Open Access Journals (Sweden)

    Li HF

    2015-06-01

    Full Text Available Huai-Feng Li,1–3,* Xu-An Wang,1–3,* Shan-Shan Xiang,1–3,* Yun-Ping Hu,1–3 Lin Jiang,1–3 Yi-Jun Shu,1–3 Mao-Lan Li,1–3 Xiang-Song Wu,1–3 Fei Zhang,1–3 Yuan-Yuan Ye,1–3 Hao Weng,1–3 Run-Fa Bao,1–3 Yang Cao,1–3 Wei Lu,1–3 Qian Dong,1–3 Ying-Bin Liu1–3 1Department of General Surgery, 2Laboratory of General Surgery, 3Institute of Biliary Tract Disease, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: Oleanolic acid (OA, a naturally occurring triterpenoid, exhibits potential antitumor activity in many tumor cell lines. Gallbladder carcinoma is the most common malignancy of the biliary tract, and is a highly aggressive tumor with an extremely poor prognosis. Unfortunately, the effects of OA on gallbladder carcinoma are unknown. In this study, we investigated the effects of OA on gallbladder cancer cells and the underlying mechanism. The results showed that OA inhibits proliferation of gallbladder cancer cells in a dose-dependent and time-dependent manner on MTT and colony formation assay. A flow cytometry assay revealed apoptosis and G0/G1 phase arrest in GBC-SD and NOZ cells. Western blot analysis and a mitochondrial membrane potential assay demonstrated that OA functions through the mitochondrial apoptosis pathway. Moreover, this drug inhibited tumor growth in nude mice carrying subcutaneous NOZ tumor xenografts. These data suggest that OA inhibits proliferation of gallbladder cancer cells by regulating apoptosis and the cell cycle process. Thus, OA may be a promising drug for adjuvant chemotherapy in gallbladder carcinoma. Keywords: oleanolic acid, gallbladder carcinoma, apoptosis, cell cycle arrest, mitochondrial pathway

  20. 20(S-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway

    Directory of Open Access Journals (Sweden)

    Zhang F

    2015-08-01

    Full Text Available Fei Zhang,* Maolan Li,* Xiangsong Wu,* Yunping Hu, Yang Cao, Xu’an Wang, Shanshan Xiang, Huaifeng Li, Lin Jiang, Zhujun Tan, Wei Lu, Hao Weng, Yijun Shu, Wei Gong, Xuefeng Wang, Yong Zhang, Weibin Shi, Ping Dong,# Jun Gu,# Yingbin Liu#Department of General Surgery and Laboratory of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Institute of Biliary Tract Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China *These authors contributed equally to this work #These authors jointly directed this work Abstract: Gallbladder cancer (GBC, the most frequent malignancy of the biliary tract, is associated with high mortality and extremely poor prognosis. 20(S-ginsenoside Rg3 (20(S-Rg3 is a steroidal saponin with high pharmacological activity. However, the anticancer effect of 20(S-Rg3 in human GBC has not yet been determined. In this study, we primarily found that 20(S-Rg3 exposure suppressed the survival of both NOZ and GBC-SD cell lines in a concentration-dependent manner. Moreover, induction of cellular senescence and G0/G1 arrest by 20(S-Rg3 were accompanied by a large accumulation of p53 and p21 as a result of murine double minute 2 (MDM2 inhibition. 20(S-Rg3 also caused a remarkable increase in apoptosis via the activation of the mitochondrial-mediated intrinsic caspase pathway. Furthermore, intraperitoneal injection of 20(S-Rg3 (20 or 40 mg/kg for 3 weeks markedly inhibited the growth of xenografts in nude mice. Our results demonstrated that 20(S-Rg3 potently inhibited growth and survival of GBC cells both in vitro and in vivo. 20(S-Rg3 attenuated GBC growth probably via activation of the p53 pathway, and subsequent induction of cellular senescence and mitochondrial-dependent apoptosis. Therefore, 20(S-Rg3 may be a potential chemotherapeutic agent for GBC therapy.Keywords: gallbladder cancer, 20(S-ginsenoside Rg3, senescence, apoptosis, p53 pathway

  1. Double-blind comparison of ziprasidone and risperidone in the treatment of Chinese patients with acute exacerbation of schizophrenia

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    Hongyan Zhang

    2011-03-01

    Full Text Available Hongyan Zhang1, Huafang Li2, Liang Shu1, Niufan Gu2, Gang Wang3, Yongzhen Weng3, Shiping Xie4, Xinbao Zhang4, Ting Li5, Cui Ma5, Wei Yu6, Bruce Parsons7, Manjula Schou81Institute of Mental Health, Peking University, Beijing, China; 2Shanghai Mental Health Center, Shanghai, China; 3Capital Medical University, Beijing An Ding Hospital, Beijing, China; 4Nanjing Brain Hospital, Nanjing, China; 5Guangzhou Brain Hospital, Guangzhou, China; 6Pfizer China, Beijing, China; 7Pfizer Inc, New York, NY, USA; 8Pfizer Australia, Sydney, AustraliaBackground: The aim of the study was to evaluate the efficacy and safety of ziprasidone versus risperidone in Chinese subjects with acute exacerbation of schizophrenia.Methods: In patients meeting the Chinese Classification of Mental Disorders criteria for schizophrenia and with a Positive and Negative Syndrome Scale (PANSS total score ≥60 were randomly assigned to six weeks of double-blind treatment with ziprasidone 40–80 mg twice daily or risperidone 1–3 mg bid, flexibly dosed. Noninferiority was demonstrated if the upper limit of the two-sided 95% confidence interval (CI for the difference in PANSS total score improvement from baseline in the evaluable population was smaller than the prespecified noninferiority margin of 10 units.Results: The intent-to-treat population comprised 118 ziprasidone-treated and 121 risperidone-treated subjects. Improvement (reduction from baseline to week 6 in PANSS total score was (-35.6 [95% CI: -38.6, -32.6] for ziprasidone and (-37.1 [95% CI: -39.9, -34.4] for risperidone. Noninferiority was demonstrated in the evaluable population with a difference score of 1.5 [95% CI: -2.5, 5.5]. Mean prolactin levels decreased at week 6 compared with baseline for ziprasidone (-3.5 ng/mL, but significantly increased for risperidone (61.1 ng/mL; P < 0.001. More risperidone-treated subjects (14.9% than ziprasidone-treated subjects (4.2% reported weight gain ≥7%. Akathisia and somnolence in

  2. Association between pretreatment Glasgow prognostic score and gastric cancer survival and clinicopathological features: a meta-analysis

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    Zhang CX

    2016-06-01

    Full Text Available Chun-Xiao Zhang,* Shu-Yi Wang,* Shuang-Qian Chen, Shuai-Long Yang, Lu Wan, Bin Xiong Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, Hubei, People’s Republic of China *These authors contributed equally to this work Background: Glasgow prognostic score (GPS is widely known as a systemic inflammatory-based marker. The relationship between pretreatment GPS and gastric cancer (GC survival and clinicopathological features remains controversial. The aim of the study was to conduct a meta-analysis of published studies to evaluate the association between pretreatment GPS and survival and clinicopathological features in GC patients. Methods: We searched PubMed, Embase, MEDLINE, and BioMed databases for relevant studies. Combined analyses were used to assess the association between pretreatment GPS and overall survival, disease-free survival, and clinicopathological parameters by Stata Version 12.0. Results: A total of 14 studies were included in this meta-analysis, including 5,579 GC patients. The results indicated that pretreatment high GPS (HGPS predicted poor overall survival (hazard ratio =1.51, 95% CI: 1.37–1.66, P<0.01 and disease-free survival (hazard ratio =1.45, 95% CI: 1.26–1.68, P<0.01 in GC patients. Pretreatment HGPS was also significantly associated with advanced tumor–node–metastasis stage (odds ratio [OR] =3.09, 95% CI: 2.11–4.53, P<0.01, lymph node metastasis (OR =4.60, 95% CI: 3.23–6.56, P<0.01, lymphatic invasion (OR =3.04, 95% CI: 2.00–4.62, P<0.01, and venous invasion (OR =3.56, 95% CI: 1.81–6.99, P<0.01. Conclusion: Our meta-analysis indicated that pretreatment HGPS could be a predicative factor of poor survival outcome and clinicopathological features for GC patients. Keywords: Glasgow prognostic score, gastric cancer, survival, clinicopathological feature

  3. Proteasome activity related with the daily physical activity of COPD patients

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    Lee KY

    2017-05-01

    Full Text Available Kang-Yun Lee,1,2,* Tzu-Tao Chen,1,* Ling-Ling Chiang,1,3 Hsiao-Chi Chuang,1,3 Po-Hao Feng,1,2 Wen-Te Liu,1–3 Kuan-Yuan Chen,1 Shu-Chuan Ho1,3 1Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, 2Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, 3School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan *These authors contributed equally to this work Background: COPD is a debilitating disease that affects patients’ daily lives. One’s daily physical activity (DPA decreases due to multifactorial causes, and this decrease is correlated with a poor prognosis in COPD patients. Muscle wasting may at least be partly due to increased activity of the ubiquitin proteasome pathway and apoptosis.Methods: This study investigated the relationships among DPA, circulating proteasome activity, and protein carbonyl in COPD patients and healthy subjects (HSs. This study included 57 participants (42 patients and 15 healthy subjects. Ambulatory DPA was measured using actigraphy, and oxygen saturation was measured with a pulse oximeter.Results: COPD patients had lower DPA, lower 6 min walking distance (6MWD, lower delta saturation pulse oxygenation (SpO2 during the 6MWT, and lower delta SpO2 during DPA than HSs. COPD patients had higher proteasome activity and protein carbonyl than HSs. Circulating proteasome activity was significantly negatively correlated with DPA (r=−0.568, P<0.05 in COPD patients, whereas delta SpO2 during the 6MWT was significantly positively correlated with proteasome activity (r=0.685, P<0.05 in HSs. Protein carbonyl was significantly negatively correlated with the body mass index (r=−0.318, P<0.05, mid-arm circumference (r=0.350, P<0.05, calf circumference (r=0.322, P<0.05, forced expiratory volume in the first second (r=−0.441, P<0

  4. Association between the polymorphisms of urokinase plasminogen activation system and cancer risk: a meta-analysis

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    Xu Z

    2015-09-01

    Full Text Available Zhen Xu,1,* Li-Li Meng,2,* Jizong Lin,3 Yunbiao Ling,3 Shu-xian Chen,3 Nan Lin31Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University, 2Department of Gynecology and Obstetrics, Sun Yat-sen Memorial Hospital, 3Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China *These authors contributed equally to this studyPurpose: The present study aimed to investigate the potential association between the urokinase plasminogen activation (uPA system polymorphisms (rs4065, rs2227564, and rs344781 and cancer risk.Methods: An extensive search was performed to identify published case–control studies on the association between the uPA system polymorphisms and cancer risk. Odds ratios (ORs with 95% confidence intervals (CIs were used to evaluate the relationship between the uPA system polymorphisms and cancer risk.Results: A total of 20 studies comprising 7,037 cancer cases and 10,094 controls were identified and included in the present meta-analysis. Overall, significantly increased cancer risk was associated with the uPA polymorphism rs4065 (T vs C: OR 1.50, 95% CI: 1.19–1.89; TT vs CC: OR 4.63, 95% CI: 3.10–6.91; dominant model: OR 1.93, 95% CI: 1.60–2.33; recessive model: OR 3.02, 95% CI: 1.26–7.25 and the uPA receptor polymorphism rs344781 (T vs C: OR 1.13, 95% CI: 1.04–1.23; TC vs CC: OR 1.26, 95% CI: 1.06–1.49; TT vs CC: OR 1.35, 95% CI: 1.13–1.63; dominant model: OR 1.29, 95% CI: 1.10–1.52. No significant association was found between the uPA polymorphism rs2227564 and cancer risk. Subgroup analysis suggests that the T allele of the rs4065 (T allele vs C allele: OR 1.50, 95% CI: 1.19–1.89 and rs344781 polymorphisms (T allele vs C allele: OR 1.13, 95% CI: 1.04–1.23 was associated with increased cancer risk in Asians.Conclusion: Our results suggest that the uPA polymorphism rs4065 and the uPA receptor polymorphism rs344781

  5. Acute effects of capsaicin on energy expenditure and fat oxidation in negative energy balance.

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    Pilou L H R Janssens

    Full Text Available BACKGROUND: Addition of capsaicin (CAPS to the diet has been shown to increase energy expenditure; therefore capsaicin is an interesting target for anti-obesity therapy. AIM: We investigated the 24 h effects of CAPS on energy expenditure, substrate oxidation and blood pressure during 25% negative energy balance. METHODS: Subjects underwent four 36 h sessions in a respiration chamber for measurements of energy expenditure, substrate oxidation and blood pressure. They received 100% or 75% of their daily energy requirements in the conditions '100%CAPS', '100%Control', '75%CAPS' and '75%Control'. CAPS was given at a dose of 2.56 mg (1.03 g of red chili pepper, 39,050 Scoville heat units (SHU with every meal. RESULTS: An induced negative energy balance of 25% was effectively a 20.5% negative energy balance due to adapting mechanisms. Diet-induced thermogenesis (DIT and resting energy expenditure (REE at 75%CAPS did not differ from DIT and REE at 100%Control, while at 75%Control these tended to be or were lower than at 100%Control (p = 0.05 and p = 0.02 respectively. Sleeping metabolic rate (SMR at 75%CAPS did not differ from SMR at 100%CAPS, while SMR at 75%Control was lower than at 100%CAPS (p = 0.04. Fat oxidation at 75%CAPS was higher than at 100%Control (p = 0.03, while with 75%Control it did not differ from 100%Control. Respiratory quotient (RQ was more decreased at 75%CAPS (p = 0.04 than at 75%Control (p = 0.05 when compared with 100%Control. Blood pressure did not differ between the four conditions. CONCLUSION: In an effectively 20.5% negative energy balance, consumption of 2.56 mg capsaicin per meal supports negative energy balance by counteracting the unfavorable negative energy balance effect of decrease in components of energy expenditure. Moreover, consumption of 2.56 mg capsaicin per meal promotes fat oxidation in negative energy balance and does not increase blood pressure significantly. TRIAL REGISTRATION

  6. Cognitive Style and Mobile E-Learning in Emergent Otorhinolaryngology-Head and Neck Surgery Disorders for Millennial Undergraduate Medical Students: Randomized Controlled Trial.

    Science.gov (United States)

    Lee, Li-Ang; Chao, Yi-Ping; Huang, Chung-Guei; Fang, Ji-Tseng; Wang, Shu-Ling; Chuang, Cheng-Keng; Kang, Chung-Jan; Hsin, Li-Jen; Lin, Wan-Ni; Fang, Tuan-Jen; Li, Hsueh-Yu

    2018-02-13

    different cognitive styles. Clinicaltrials.gov NCT02971735; https://clinicaltrials.gov/ct2/show/NCT02971735 (Archived by WebCite at http://www.webcitation.org/6waoOpCEV). ©Li-Ang Lee, Yi-Ping Chao, Chung-Guei Huang, Ji-Tseng Fang, Shu-Ling Wang, Cheng-Keng Chuang, Chung-Jan Kang, Li-Jen Hsin, Wan-Ni Lin, Tuan-Jen Fang, Hsueh-Yu Li. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 13.02.2018.

  7. UNVEILING THE DETAILED DENSITY AND VELOCITY STRUCTURES OF THE PROTOSTELLAR CORE B335

    Energy Technology Data Exchange (ETDEWEB)

    Kurono, Yasutaka; Saito, Masao; Kamazaki, Takeshi; Morita, Koh-Ichiro; Kawabe, Ryohei, E-mail: yasutaka.kurono@nao.ac.jp [Chile Observatory, National Astronomical Observatory of Japan, Osawa 2-21-1, Mitaka, Tokyo 181-8588 (Japan)

    2013-03-10

    We present an observational study of the protostellar core B335 harboring a low-mass Class 0 source. The observations of the H{sup 13}CO{sup +}(J = 1-0) line emission were carried out using the Nobeyama 45 m telescope and Nobeyama Millimeter Array. Our combined image of the interferometer and single-dish data depicts detailed structures of the dense envelope within the core. We found that the core has a radial density profile of n(r){proportional_to}r {sup -p} and a reliable difference in the power-law indices between the outer and inner regions of the core: p Almost-Equal-To 2 for r {approx}> 4000 AU and p Almost-Equal-To 1.5 for r {approx}< 4000 AU. The dense core shows a slight overall velocity gradient of {approx}1.0 km s{sup -1} over the scale of 20, 000 AU across the outflow axis. We believe that this velocity gradient represents a solid-body-like rotation of the core. The dense envelope has a quite symmetrical velocity structure with a remarkable line broadening toward the core center, which is especially prominent in the position-velocity diagram across the outflow axis. The model calculations of position-velocity diagrams do a good job of reproducing observational results using the collapse model of an isothermal sphere in which the core has an inner free-fall region and an outer region conserving the conditions at the formation stage of a central stellar object. We derived a central stellar mass of {approx}0.1 M{sub Sun }, and suggest a small inward velocity, v{sub r{>=}r{sub i{sub n{sub f}}}}{approx}0 km s{sup -1} in the outer core at {approx}> 4000 AU. We concluded that our data can be well explained by gravitational collapse with a quasi-static initial condition, such as Shu's model, or by the isothermal collapse of a marginally critical Bonnor-Ebert sphere.

  8. Question Word in the Mandarin Language

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    Xu Yunyu

    2016-12-01

    Full Text Available In an interrogative sentence in Mandarin language, a question word can be placed in the beginning, middle or end of a sentence. Because of the different nation and culture, when a foreign student learns Mandarin, they find it difficult to understand the question words and the position of the question words in that language. Because of that, the writer proposes to explain such problems. This research aims to find out what are the types of question words in Mandarin, and also to explain the function and usage of question words in the Mandarin interrogative sentence. An interrogative sentence is a very important sentence. In Mandarin, the following question words: 谁(shuí “Who”,在哪里(zài nǎli “where”, 在哪儿(zài nǎ’er “where”,为什么(wèi shénme “why”, 怎么(zěnme “why”,多少(duō shǎo) “how many”,多久(duō jiǔ “how long”,什么时候 (shénme shíhòu “when”,什么(shénme “what”,做什么(zuò shénme “why”,干 什么(gàn shénme “why”,干嘛(gànma “why” and so on are used to ask “who”, “where”, “what”, “how much”, “when”, “what time”, and “why”. Those words have different functions and usage. Each sentence has a certain structure and word order. A question word can be placed in the beginning, middle, or end of a sentence. When the place is changed, there is a possibility of miscommunication.   DOI: https://doi.org/10.24071/llt.2013.160106

  9. The Sloan Lens ACS Survey. XIII. Discovery of 40 New Galaxy-scale Strong Lenses

    Science.gov (United States)

    Shu, Yiping; Brownstein, Joel R.; Bolton, Adam S.; Koopmans, Léon V. E.; Treu, Tommaso; Montero-Dorta, Antonio D.; Auger, Matthew W.; Czoske, Oliver; Gavazzi, Raphaël; Marshall, Philip J.; Moustakas, Leonidas A.

    2017-12-01

    We present the full sample of 118 galaxy-scale strong-lens candidates in the Sloan Lens ACS (SLACS) Survey for the Masses (S4TM) Survey, which are spectroscopically selected from the final data release of the Sloan Digital Sky Survey. Follow-up Hubble Space Telescope (HST) imaging observations confirm that 40 candidates are definite strong lenses with multiple lensed images. The foreground-lens galaxies are found to be early-type galaxies (ETGs) at redshifts 0.06–0.44, and background sources are emission-line galaxies at redshifts 0.22–1.29. As an extension of the SLACS Survey, the S4TM Survey is the first attempt to preferentially search for strong-lens systems with relatively lower lens masses than those in the pre-existing strong-lens samples. By fitting HST data with a singular isothermal ellipsoid model, we find that the total projected mass within the Einstein radius of the S4TM strong-lens sample ranges from 3 × 1010 M ⊙ to 2 × 1011 M ⊙. In Shu et al., we have derived the total stellar mass of the S4TM lenses to be 5 × 1010 M ⊙ to 1 × 1012 M ⊙. Both the total enclosed mass and stellar mass of the S4TM lenses are on average almost a factor of 2 smaller than those of the SLACS lenses, which also represent the typical mass scales of the current strong-lens samples. The extended mass coverage provided by the S4TM sample can enable a direct test, with the aid of strong lensing, for transitions in scaling relations, kinematic properties, mass structure, and dark-matter content trends of ETGs at intermediate-mass scales as noted in previous studies. Based on observations made with the NASA/ESA Hubble Space Telescope (HST), obtained at the Space Telescope Science Institute, which is operated by AURA, Inc., under NASA contract NAS 5-26555. These observations are associated with HST program #12210.

  10. Effect of image-guided hypofractionated stereotactic radiotherapy on peripheral non-small-cell lung cancer

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    Wang SW

    2016-08-01

    Full Text Available Shu-wen Wang,1 Juan Ren,1 Yan-li Yan,2 Chao-fan Xue,2 Li Tan,2 Xiao-wei Ma2 1Department of Radiotherapy, First Affiliated Hospital of Xian Jiaotong University, 2Medical School of Xian Jiaotong University, Xi’an, Shaanxi, People’s Republic of China Abstract: The objective of this study was to compare the effects of image-guided hypofractionated radiotherapy and conventional fractionated radiotherapy on non-small-cell lung cancer (NSCLC. Fifty stage- and age-matched cases with NSCLC were randomly divided into two groups (A and B. There were 23 cases in group A and 27 cases in group B. Image-guided radiotherapy (IGRT and stereotactic radiotherapy were conjugately applied to the patients in group A. Group A patients underwent hypofractionated radiotherapy (6–8 Gy/time three times per week, with a total dose of 64–66 Gy; group B received conventional fractionated radiotherapy, with a total dose of 68–70 Gy five times per week. In group A, 1-year and 2-year local failure survival rate and 1-year local failure-free survival rate were significantly higher than in group B (P<0.05. The local failure rate (P<0.05 and distant metastasis rate (P>0.05 were lower in group A than in group B. The overall survival rate of group A was significantly higher than that of group B (P=0.03, and the survival rate at 1 year was 87% vs 63%, (P<0.05. The median survival time of group A was longer than that of group B. There was no significant difference in the incidence of complications between the two groups (P>0.05. Compared with conventional fractionated radiation therapy, image-guided hypofractionated stereotactic radiotherapy in NSCLC received better treatment efficacy and showed good tolerability. Keywords: non-small-cell lung cancer, hypofractionated radiotherapy, stereotactic radiotherapy, segmentation, intensity-modulated radiotherapy, image-guided radiation therapy technology

  11. Clinical manifestations of pulmonary mucosa-associated lymphoid tissue lymphoma: single-center experience with 18 patients

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    Zhao S

    2018-01-01

    Full Text Available Shasha Zhao,1,2 Lin Zhang,3 Zhenyang Gu,1 Chengying Zhu,1,2 Shu Fang,1 Nan Yang,1 Feiyan Wang,1,2 Lixun Guan,1 Lan Luo,1 Chunji Gao1 1Department of Hematology, Chinese People’s Liberation Army (PLA General Hospital, Beijing, 2School of Medicine, Nankai University, Tianjin, 3Department of Hematology, First Hospital of Qinhuangdao, Qinhuangdao, China Purpose: Pulmonary mucosa-associated lymphoid tissue (MALT lymphoma is a rare entity. To date, the optimal treatment for this disease is still under debate. The aim of this study was to analyze and summarize the clinical manifestations and therapeutic experience of 18 pulmonary MALT lymphoma patients to collect information about the optimal treatment modality. Patients and methods: A retrospective analysis was performed in patients who were diagnosed with pulmonary MALT lymphoma at the Chinese People’s Liberation Army General Hospital from April 1995 to April 2016. Results: Clinical data of 18 patients were available. The median age was 55 (range, 34–67 years. Also, 61.1% of the patients were male. Only 33.3% had a history of smoking and 27.8% of the patients had tuberculosis. Treatment modalities included surgery alone in 1 patient (5.6%, chemotherapy in 10 patients (55.5%, surgery in combination with chemotherapy in 6 patients (33.3% and observation in 1 patient (5.6%. Over the median observation period of 93 months, 2 patients died, the median progression-free survival was 6 years, and the estimated 5- and 10-year overall survival rates were 94.1% and 83.7%, respectively. The survival data confirmed the indolent nature of the disease. There was no difference in progression-free survival between the chemotherapy group and the surgery in combination with chemotherapy group. Conclusion: Pulmonary MALT lymphoma tended to be an indolent disease. In order to preserve the lung function and reduce the risks associated with surgery, chemotherapy might be an optimal choice for the treatment of

  12. Modelling and simulation of compressible fluid flow in oil reservoir: a case study of the Jubilee Field, Tano Basin (Ghana)

    International Nuclear Information System (INIS)

    Gawusu, S.

    2015-07-01

    -phase petroleum reservoirs was described by a system of coupled, nonlinear, Partial Differential Equations (PDE). An analytical solution procedure was adopted and adapted from (Perapon and Yu-Shu, 2010) for the system of equations. (author)

  13. Comparative Analysis of Fruit Metabolites and Pungency Candidate Genes Expression between Bhut Jolokia and Other Capsicum Species.

    Science.gov (United States)

    M, Sarpras; Gaur, Rashmi; Sharma, Vineet; Chhapekar, Sushil Satish; Das, Jharna; Kumar, Ajay; Yadava, Satish Kumar; Nitin, Mukesh; Brahma, Vijaya; Abraham, Suresh K; Ramchiary, Nirala

    2016-01-01

    Bhut jolokia, commonly known as Ghost chili, a native Capsicum species found in North East India was recorded as the naturally occurring hottest chili in the world by the Guinness Book of World Records in 2006. Although few studies have reported variation in pungency content of this particular species, no study till date has reported detailed expression analysis of candidate genes involved in capsaicinoids (pungency) biosynthesis pathway and other fruit metabolites. Therefore, the present study was designed to evaluate the diversity of fruit morphology, fruiting habit, capsaicinoids and other metabolite contents in 136 different genotypes mainly collected from North East India. Significant intra and inter-specific variations for fruit morphological traits, fruiting habits and 65 fruit metabolites were observed in the collected Capsicum germplasm belonging to three Capsicum species i.e., Capsicum chinense (Bhut jolokia, 63 accessions), C. frutescens (17 accessions) and C. annuum (56 accessions). The pungency level, measured in Scoville Heat Unit (SHU) and antioxidant activity measured by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay showed maximum levels in C. chinense accessions followed by C. frutescens accessions, while C. annuum accessions showed the lowest value for both the traits. The number of different fruit metabolites detected did not vary significantly among the different species but the metabolite such as benzoic acid hydroxyl esters identified in large percentage in majority of C. annuum genotypes was totally absent in the C. chinense genotypes and sparingly present in few genotypes of C. frutescens. Significant correlations were observed between fruit metabolites capsaicin, dihydrocapsaicin, hexadecanoic acid, cyclopentane, α-tocopherol and antioxidant activity. Furthermore, comparative expression analysis (through qRT-PCR) of candidate genes involved in capsaicinoid biosynthesis pathway revealed many fold higher expression of

  14. Modelling of Resonantly Forced Density Waves in Dense Planetary Rings

    Science.gov (United States)

    Lehmann, M.; Schmidt, J.; Salo, H.

    2014-04-01

    Density wave theory, originally proposed to explain the spiral structure of galactic disks, has been applied to explain parts of the complex sub-structure in Saturn's rings, such as the wavetrains excited at the inner Lindblad resonances (ILR) of various satellites. The linear theory for the excitation and damping of density waves in Saturn's rings is fairly well developed (e.g. Goldreich & Tremaine [1979]; Shu [1984]). However, it fails to describe certain aspects of the observed waves. The non-applicability of the linear theory is already indicated by the "cusplike" shape of many of the observed wave profiles. This is a typical nonlinear feature which is also present in overstability wavetrains (Schmidt & Salo [2003]; Latter & Ogilvie [2010]). In particular, it turns out that the detailed damping mechanism, as well as the role of different nonlinear effects on the propagation of density waves remain intransparent. First attemps are being made to investigate the excitation and propagation of nonlinear density waves within a hydrodynamical formalism, which is also the natural formalism for describing linear density waves. A simple weakly nonlinear model, derived from a multiple-scale expansion of the hydrodynamic equations, is presented. This model describes the damping of "free" spiral density waves in a vertically integrated fluid disk with density dependent transport coefficients, where the effects of the hydrodynamic nonlinearities are included. The model predicts that density waves are linearly unstable in a ring region where the conditions for viscous overstability are met, which translates to a steep dependence of the shear viscosity with respect to the disk's surface density. The possibility that this dependence could lead to a growth of density waves with increasing distance from the resonance, was already mentioned in Goldreich & Tremaine [1978]. Sufficiently far away from the ILR, the surface density perturbation caused by the wave, is predicted to

  15. Comparison of single-agent chemotherapy and targeted therapy to first-line treatment in patients aged 80 years and older with advanced non-small-cell lung cancer

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    Zhang QQ

    2015-04-01

    Full Text Available Qianqian Zhang,1 Zhehai Wang,2 Jun Guo,2 Liyan Liu,2 Xiao Han,2 Minmin Li,1 Shu Fang,1 Xiang Bi,1 Ning Tang,1 Yang Liu1 1School of Medicine and Life Sciences, Shandong Academy of Medical Sciences, University of Jinan, 2Department of Oncology, Shandong Cancer Hospital, Jinan, People’s Republic of China Purpose: The aim of this study was to compare single-agent chemotherapy with targeted therapy in initial treatment and to explore a better choice of treatment for patients aged 80 years and older with advanced non-small-cell lung cancer (NSCLC.Patients and methods: A retrospective chart review was conducted for 136 patients aged 80 years and older who were cytopathologically diagnosed and staged as advanced (stage IIIB or IV NSCLC. The patient population was divided into two treatment groups: 78 patients were allocated to the chemotherapy group (group A, pemetrexed or gemcitabine or docetaxel as a single agent, and 60 patients were allocated to another group and received epidermal growth factor-receptor tyrosine-kinase inhibitors (group B, erlotinib or gefitinib as a single agent. The primary end points were overall survival (OS and progression-free survival (PFS, and the secondary end points were response rate, disease-control rate, safety, and quality of life.Results: In group A and group B, respectively, the median PFS was 2 versus 4 months (P=0.013, and the median OS was 8 versus 16 months (P=0.025. The 1- and 2-year survival rates of the two groups were 23.7% (group A, 18 of 76 versus 76.7% (group B, 46 of 60 and 13.2% (group A, ten of 76 versus 10% (group B, six of 60, respectively. The response rate and disease-control rate were 28.9% versus 36.7% (P=0.39 and 57.9% versus 76.7% (P=0.022 in group A and group B, respectively.Conclusion: Elders aged 80 years and over with advanced NSCLC in group B had longer PFS and OS compared with group A. It was well tolerated in group B because of the mild adverse effects. Targeted therapy can be

  16. POLYPHENOLS, ASCORBIC ACID AND CAROTENOIDS CONTENTS AND ANTIOXIDANT PROPERTIES IN FRUITS OF CAPSICUM CHINENSE JACQ.

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    M. I. Mamedov

    2016-01-01

    Full Text Available Capsicum chinense Jacq. is the rich source of phytochemical substances, such as vitamin C, phenolic compounds, carotenoids, and occupies a significant place in the cooking of many peoples. The pigment composition, the amount of carotenoids, ascorbic acid and their contribution to the formation of antioxidant properties were studied. The total content of carotenoids and red/yellow pigments varied greatly among the accessions of C. chinense. The highest content of carotenoids 0.581 mg/g was observed in the varieties ‘Ognennaya Deva’ with the red fruit color in the phase of biological ripeness, where red pigments accumulated 56% more than in yellow ones. Fruits of accessions ‘Kolokolchik’ only accumulated yellow pigments, 0.318 mg/g. Presence of significant amount, 2.03 times as much red pigments as yellow ones in the variety ‘Trinidad Scorpion Chocolate’, with protein complex could cause the formation of a brown fruit color. Another tendency was observed in ‘Trinidad Dglahou’. The yellow pigment is 1.5 times as much amount as red, as estimated 0.119 mg/g of yellow and 0.077 mg/g of red pigment. The ascorbic acid content did not depend on the fruit color. Fruits of the ‘Ognennaya Deva’ accumulated the highest amount of ascorbic acid, 301 mg%. The maximum total antioxidant content, was detected in the variety ‘Ognennaya Deva’ 2.65 (TAC, mg.eq. GA/g. Analysis of the dependence of the content of thermo stable antioxidants to the total ones showed the contribution of the unstable antioxidants to thermal effects (particularly ascorbic acid on the level of 16%, on average. A comparative assessment of the pungency level and quantitative capsaicin content in the fruit was carried out by organoleptic, spectrophotometric and HPLC methods. The intervals of observed concentrations of capsaicin were 1.0-7.5 mg/g of dry weight (HPLC, the level of pungency on the Scoville scale was 17440-153120 SHU. There

  17. Meta-analysis of the impact of de novo and acquired EGFR T790M mutations on the prognosis of patients with non-small cell lung cancer receiving EGFR-TKIs

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    Liu Y

    2017-04-01

    Full Text Available Yang Liu, Li Sun, Zhi-Cheng Xiong, Xin Sun, Shu-Ling Zhang, Jie-Tao Ma, Cheng-Bo Han Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China Purpose: The purpose of this meta-analysis was to explore the influences of pretreatment de novo and posttreatment-acquired epidermal growth factor receptor (EGFR T790M mutations in patients with advanced non-small cell lung cancer (NSCLC who had received tyrosine kinase inhibitors (TKIs.Methods: We searched PubMed, Embase, and the China National Knowledge Infrastructure database for eligible literature. Data were extracted to assess the hazard ratios (HRs for progression-free survival (PFS, overall survival (OS, and post-progression survival (PPS and the relative ratios (RRs for objective response rate (ORR.Results: This meta-analysis included 22 studies comprising 1,462 patients with NSCLC who harbored activating EGFR mutations and were treated with EGFR-TKIs. Compared to pretreatment T790M mutation-negative NSCLC, pretreatment T790M mutation-positive NSCLC was associated with decreased PFS (HR 2.23, P<0.001 and OS (HR 1.55, P=0.003. A trend toward significance of worsening ORR (RR 0.86, P=0.051 was evident. The acquired T790M mutation was correlated with improved PFS (HR 0.75, P=0.006 and PPS (HR 0.57, P<0.001, compared to patients without the T790M mutation who progressed after EGFR-TKI treatment. There were no significant differences in OS or ORR between patients with acquired T790M mutation-positive and T790M mutation-negative NSCLC. However, in the tumor tissue rebiopsy subgroup, patients with acquired T790M mutation had improved OS (HR 0.60, P<0.001 compared to T790M mutation-negative patients. In the plasma ctDNA subgroup, acquired T790M mutation decreased the OS (HR 1.87, P<0.001.Conclusion: Pretreatment T790M mutation was associated with worse PFS and OS in patients with advanced NSCLC treated with EGFR-TKIs, while acquired T790M mutation was

  18. Development and validation of a scale to measure patients’ trust in pharmacists in Singapore

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    Xu-Hao Zhang

    2008-11-01

    Full Text Available Xu-Hao Zhang1, Jing Jin1, Surachat Ngorsuraches2, Shu-Chuen Li31Department of Pharmacy, National University of Singapore, Republic of Singapore; 2Department of Pharmacy Administration, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Thailand; 3Discipline of Pharmacy and Experimental Pharmacology, School of Biomedical Sciences, University of Newcastle, Newcastle, AustraliaObjective: To develop and validate a scale to measure patients’ trust in pharmacists for use as an outcomes predictor in pharmacoeconomic and pharmaceutical care studies.Methods: Literature review, study team discussion and focus group discussions were conducted to generate items of a candidate version to be pilot-tested for content validity. An amended candidate version was then tested among eligible Singaporeans across different ethnic and age groups. Score distributions were assessed for discriminatory power and item analyses for finalizing items. Exploratory factor analysis was used to identify dimensionality and homogeneous items. Cronbach’s alpha was measured for internal consistency and Pearson’s correlation coefficients for convergent validity.Results: Eighteen items were generated with good variability (SD > 1.0 and symmetry (means ranged from −1 to 1 for score distribution. After minor changes to improve content clarity, the amended questionnaire was self-administered among 1196 respondents [mean (SD age: 38.6 (14.9 years, 51.6% female, 87% >6 years of education]. Six items were dropped due to inadequate item-total correlation coefficients, leaving 12-item scale for factor analysis. Three factors (“benevolence”, “technical competence” and “global trust” were identified, accounting for 55% of the total variance. Cronbach’s alpha was 0.83, indicating high internal consistency. Convergent validity was demonstrated by statistically significant positive correlations between trust and patients’ satisfaction with pharmacists

  19. Breyten Breytenbach in een zijspiegel: Het vizier van H.C. ten Berge Transnationale laterale beweging en particuliere “hetero-images” van een literaire actor/ Breyten Breytenbach Through H.C. ten Berge’s Looking-Glass: Transnational Lateral Movement and Particular “Hetero-Images” of a Writer

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    T’Sjoen Yves

    2015-06-01

    Full Text Available At the end of the 1960s and in the beginning of the 1970s the South African poet Breyten Breytenbach had poetry and drawings published in the leading literary magazine Raster. The editor in charge at the time, H.C. ten Berge, gave the experimental writer and socially engaged Sestiger (the literary modernizing movement in South Africa in the sixties pride of place in the line-ups of the Dutch modernist periodical. In the seventies, Ten Berge contributed to Vingermaan (1980, a collection of poems by Dutch writers (Lucebert, Kopland, Kouwenaar, Schierbeek in support of the anti-apartheid activist. From 1975 Breytenbach was imprisoned in South Africa for political reasons. He served seven years of a nine year sentence. At that time, in the eighties, the Netherlands organized a cultural and economical boycott against the racist regime in Pretoria. Later on, Ten Berge presented his own poems dedicated to Breytenbach in his book of poetry Nieuwe gedichten (1981 and in the collection Materia prima: Gedichten 1963-1993 (1993. Before and during the imprisonment of Breytenbach Ten Berge played an important role in the introduction of the writer in the Low Countries. From a cultural-sociological point of view Breytenbach’s presence in the Dutch language area can be described, in the terminology of Francoise Lionnet and Shu-mei Shih and later on used by Louise Viljoen, as a transnational lateral movement in his writing career. This paper deals with the cultural transmission of an important political and experimental author in the literary system of Afrikaans and English in South Africa into the Dutch system. From a bibliographical viewpoint this paper affords special attention to the publication of Breytenbach’s volume of poetry in Skryt: Om ’n sinkende skip blou te verf ([1972] 1976, Vingermaan (1980 and Nieuwe gedichten ([1981] 1987. Ten Berge played an important role in the introduction of Breytenbach to the Low Countries in the way he presented the

  20. Short-term efficacy of calcium fructoborate on subjects with knee discomfort: a comparative, double-blind, placebo-controlled clinical study

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    Pietrzkowski Z

    2014-06-01

    Full Text Available Zbigniew Pietrzkowski,1 Michael J Phelan,2 Robert Keller,3 Cynthia Shu,1 Ruby Argumedo,1 Tania Reyes-Izquierdo11FutureCeuticals, Inc., Applied BioClinical Laboratory; 2Department of Statistics, School of Information and Computer Science, University of California at Irvine; 3NutraClinical Inc., Irvine, CA, USAAbstract: Calcium fructoborate (CFB at a dose of 110 mg twice per day was previously reported to improve knee discomfort during the first 14 days of treatment. In this study, 60 participants with self-reported knee discomfort were randomized into two groups receiving CFB or placebo. Initial levels of knee discomfort were evaluated by Western Ontario and McMaster Universities Arthritis Index (WOMAC and McGill Pain Questionnaire (MPQ scores at the beginning of the study and also at 7 and 14 days after treatment. Results showed that supplementation with CFB significantly improved knee discomfort in the study subjects; significant reductions of mean within-subject change in WOMAC and MPQ scores were observed for the CFB group compared to the placebo group at both 7 and 14 days after treatment. Estimated treatment differences for the MPQ score were -5.8 (P=0.0009 and -8.9 (P<0.0001 at Day 7 and 14, respectively. Estimated differences for the WOMAC score were -5.3 (P=0.06 and -13.73 (P<0.0001 at Day 7 and 14, respectively. Negative values indicate greater reductions in reported discomfort. On both Day 7 and Day 14, the trend was toward greater improvement in the CFB group. The placebo group did not exhibit any change in the WOMAC and MPQ scores. In conclusion, supplementation with 110 mg CFB twice per day was associated with improving knee discomfort during the 2 weeks of intake.Keywords: CFB, joint discomfort, WOMAC score, McGill pain score

  1. Matrix-induced autologous chondrocyte implantation for the treatment of chondral defects of the knees in Chinese patients

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    Zhang ZW

    2014-12-01

    Full Text Available Zhongwen Zhang,1 Xin Zhong,2 Huiru Ji,1 Zibin Tang,1 Jianpeng Bai,1 Minmin Yao,1 Jianlei Hou,1 Minghao Zheng,3 David J Wood,3 Jiazhi Sun,4 Shu-Feng Zhou,4,5 Aibing Liu6 1Department of Orthopedics, General Hospital of Chinese People’s Armed Police Forces (CAPF, Beijing; 2Department of MRI Center, General Hospital of CAPF, Beijing, People’s Republic of China; 3Center for Orthopedic Research, School of Surgery and Pathology, University of Western Australia, Perth, Western Australia, Australia; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA; 5Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino–US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, Guizhou; 6Medical Research Center, General Hospital of Chinese People’s Armed Police Forces (CAPF, Beijing, People’s Republic of China Abstract: Articular cartilage injury is the most common type of damage seen in clinical orthopedic practice. The matrix-induced autologous chondrocyte implant (MACI was developed to repair articular cartilage with an advance on the autologous chondrocyte implant procedure. This study aimed to evaluate whether MACI is a safe and efficacious cartilage repair treatment for patients with knee cartilage lesions. The primary outcomes were the Knee Injury and Osteoarthritis Outcome Score (KOOS domains and magnetic resonance imaging (MRI results, compared between baseline and postoperative months 3, 6, 12, and 24. A total of 15 patients (20 knees, with an average age of 33.9 years, had a mean defect size of 4.01 cm2. By 6-month follow-up, KOOS results demonstrated significant improvements in symptoms and knee-related quality of life. MRI showed significant improvements in four individual graft scoring parameters at 24 months postoperatively. At 24 months, 90% of MACI grafts had filled completely and 10% had good

  2. Inter-eye comparison of retinal oximetry and vessel caliber between eyes with asymmetrical glaucoma severity in different glaucoma subtypes

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    Cheng CS

    2016-07-01

    Full Text Available Clarissa Shu Ming Cheng,1,2 Yi Fang Lee,2 Charles Ong,3 Zhu Li Yap,2 Andrew Tsai,2 Aditi Mohla,2 Monisha E Nongpiur,4 Tin Aung,2,4 Shamira A Perera2,4 1Department of Ophthalmology, Tan Tock Seng Hospital, 2Department of Ophthalmology, Singapore National Eye Centre, 3Yong Loo Lin School of Medicine, National University of Singapore, 4Singapore Eye Research Institute, Singapore National Eye Centre, Singapore Background: To compare retinal vessel oxygenation and vessel caliber in primary angle-closure glaucoma (PACG, primary open-angle glaucoma (POAG, normal-tension glaucoma (NTG, and normal controls, as well as between eyes of asymmetrical glaucoma severity.Methods: This was a prospective, cross-sectional study. The 159 subjects (PACG, n=39; POAG, n=41; NTG, n=41; normal controls, n=38 underwent retinal oxygen saturation measurements using the Oxymap T1 Retinal Oximeter, optical coherence tomography, and Humphrey visual field testing. Retinal oxygen saturation and vessel diameter were compared between the glaucoma groups and normal controls, as well as between eyes of asymmetrical glaucoma severity. Kruskal–Wallis test was performed for comparison among different subtypes of glaucoma. Wilcoxon signed-rank test was used to compare the inter-eye differences.Results: Compared to normal controls, arteriolar oxygen saturation was increased in PACG eyes (P=0.048 but not in POAG or NTG eyes. There were no significant differences in oxygen saturation in venules or arteriovenous (AV difference in all three glaucoma groups. Venular diameter was significantly reduced in all glaucoma groups compared to normal controls (P<0.001, but no such change was observed in arteriolar diameter (P=0.10. When comparing between eyes of asymmetrical glaucoma severity, arteriolar oxygen saturation (P=0.03 and AV difference (P=0.04 were significantly higher, while arteriolar diameter was significantly lower (P=0.001 in the worse eye in PACG group. There were no significant

  3. Synthesis, characterization, and in vivo efficacy evaluation of PGG–docetaxel conjugate for potential cancer chemotherapy

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    Jiang X

    2012-02-01

    Full Text Available Danbo Yang1, Sang Van2, Yingyi Shu1, Xiaoqing Liu1, Yangfeng Ge1, Xinguo Jiang3, Yi Jin2, Lei Yu1,21Biomedical Engineering and Technology Institute, Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, People’s Republic of China; 2Biomedical Group, Nitto Denko Technical Corporation, CA, USA; 3School of Pharmacy, Fudan University, Shanghai, People’s Republic of ChinaAim: This work is intended to develop and evaluate a biopolymeric poly(L-γ-glutamyl-glutamine (PGG–docetaxel (DTX conjugate that can spontaneously self-assemble in aqueous solutions to become nanoparticles.Methods: DTX was covalently attached to hydrophilic PGG by direct esterification, and the conjugate was characterized by proton nuclear magnetic resonance spectroscopy, molecular weight gel permeation chromatography, solubility, size distribution and morphology, and hemolysis. Conjugated DTX was found to have 2000 times improved water solubility compared with free DTX. Dynamic light scattering, transmission electron microscopy, and atomic force microscopy revealed the particle size, distribution and morphology of the PGG–DTX conjugate. In addition, the conjugate was further tested for in vitro cytotoxicity and in vivo antitumor efficacy on the human non-small cell lung cancer cell line NCI-H460.Results: Conjugated DTX was found to have 2000 times improved water solubility compared with free DTX. The conjugate formed nanoparticles with an average diameter of 30 nm in spherical shape and unimodal particle size distribution. The conjugate exhibited about 2% hemolysis at 10 mg/mL, compared with 56% for Tween 80® at 0.4 mg/mL, and 33% for Cremophor EL® at 10 mg/mL. In addition, the conjugate was further tested for in vitro cytotoxicity and in vivo antitumor efficacy on the human non-small cell lung cancer cell line NCI-H460. As expected, conjugated DTX exhibited lower cytotoxicity compared to that of free DTX, in concentration

  4. Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy

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    Wu B

    2017-06-01

    Full Text Available Bo Wu,1,* Bing Wan,2,* Shu-Ting Lu,1 Kai Deng,3 Xiao-Qi Li,1 Bao-Lin Wu,1 Yu-Shuang Li,1 Ru-Fang Liao,1 Shi-Wen Huang,3 Hai-Bo Xu1,2 1Department of Radiology, Zhongnan Hospital of Wuhan University, 2Department of Radiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, 3Department of Chemistry, Key Laboratory of Biomedical Polymers, Ministry of Education, Wuhan University, Wuhan, People’s Republic of China *These authors contributed equally to this work Abstract: The major challenge in current clinic contrast agents (CAs and chemotherapy is the poor tumor selectivity and response. Based on the self-quench property of IR820 at high concentrations, and different contrast effect ability of Gd-DOTA between inner and outer of liposome, we developed “bomb-like” light-triggered CAs (LTCAs for enhanced CT/MRI/FI multimodal imaging, which can improve the signal-to-noise ratio of tumor tissue specifically. IR820, Iohexol and Gd-chelates were firstly encapsulated into the thermal-sensitive nanocarrier with a high concentration. This will result in protection and fluorescence quenching. Then, the release of CAs was triggered by near-infrared (NIR light laser irradiation, which will lead to fluorescence and MRI activation and enable imaging of inflammation. In vitro and in vivo experiments demonstrated that LTCAs with 808 nm laser irradiation have shorter T1 relaxation time in MRI and stronger intensity in FI compared to those without irradiation. Additionally, due to the high photothermal conversion efficiency of IR820, the injection of LTCAs was demonstrated to completely inhibit C6 tumor growth in nude mice up to 17 days after NIR laser irradiation. The results indicate that the LTCAs can serve as a promising platform for NIR-activated multimodal imaging and photothermal therapy. Keywords: light triggered, near-infrared light, tumor-specific, multimodal imaging, photothermal therapy, contrast agents

  5. High resolution seismic stratigraphic analysis. An integrated approach to the subsurface geology of the SE Persian Gulf[Paper 2 is not open for the public

    Energy Technology Data Exchange (ETDEWEB)

    Farzadi, Pourdad

    2006-07-01

    The integration of seismic stratigraphy with depositional-sequence concepts has revolutionized the geologist's ability to predict subsurface stratigraphy. Describing sub-seismic-scale geometric and depositional cycle relationships within the larger, seismic-scale chronostratigraphic framework has given fascinating insights into carbonate platform evolution. Carbonates deposited on passive continental margins, such as on northeastern Arabian Platform which is the subject of this study, contain some of the major hydrocarbon accumulations of the world. As such, the study of their stratal geometric evolution has considerable relevance to hydrocarbon exploration. The first stage of this study focuses on the Cenomanian Mishrif and Khatiyah Formations in SE Persian Gulf. Working with 40 Hz conventional 3D seismic data in the first stage illustrated that, in comparison with high-resolution outcrop-defined sequences in the literature, the third-order sequence scale (composite sequence scale) within the Cenomanian Mishrif and Khatiyah Formations is seismically resolvable. This study brings new insight into carbonate platform evolution from the interpretation of the Khatiyah Formation, which is known only as a regional source rock, leading to recognition of a very low-risk prospect reservoir. The new information gained from the successive stages of drowning and back-stepping of carbonate platforms has important implications for reservoir development and can serve as a reference for regional stratigraphy. The seismic interpretation of the Aptian Dariyan Formation, a potential regional reservoir unit, illustrates that conventional seismic data are insufficient to reveal the internal heterogeneity. Outcrop examples of the laterally-equivalent Shu'aiba Formation, a prolific carbonate reservoir in the UAE, indicate the Dariyan Formation should have a complex internal architecture. However complex internal geometries are apparently not seismically resolvable in the

  6. Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237 on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway

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    Niu NK

    2015-03-01

    Full Text Available Ning-Kui Niu,1–3 Zi-Li Wang,1 Shu-Ting Pan,2,4 Hui-Qiang Ding,1 Giang HT Au,2 Zhi-Xu He,5 Zhi-Wei Zhou,2,5 Guozhi Xiao,6 Yin-Xue Yang,7 Xueji Zhang,8 Tianxin Yang,9 Xiao-Wu Chen,10 Jia-Xuan Qiu,4 Shu-Feng Zhou2 1Department of Spinal Surgery, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Department of Orthopedics, General Hospital of Tianjin Medical University, Tianjin, 4Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 5Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China; 6Department of Biochemistry, Medical Center, Rush University, Chicago, IL, USA; 7Department of Colorectal Surgery, General Hospital of Ningxia Medical University, Yinchuan, 8Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, People’s Republic of China; 9Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT, USA; 10Department of General Surgery, The First People’s Hospital of Shunde affiliated to Southern Medical University, Foshan, Guangdong, People’s Republic of China Abstract: Osteosarcoma (OS is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN8237 is a selective Aurora kinase A inhibitor that displays anticancer effects on several types of cancer. However, the role of ALS in the treatment of OS remains unknown. This study aimed to investigate the effects of ALS on the cell growth, apoptosis, autophagy, and epithelial to

  7. Mining Educational Data to Analyze the Student Motivation Behavior

    OpenAIRE

    Kunyanuth Kularbphettong; Cholticha Tongsiri

    2012-01-01

    The purpose of this research aims to discover the knowledge for analysis student motivation behavior on e-Learning based on Data Mining Techniques, in case of the Information Technology for Communication and Learning Course at Suan Sunandha Rajabhat University. The data mining techniques was applied in this research including association rules, classification techniques. The results showed that using data mining technique can indicate the important variables that influenc...

  8. Dissociations between word and picture naming in Persian speakers with aphasia

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    Mehdi Bakhtiar

    2014-04-01

    for lexical access for phonological output: a semantic route for picture naming and a route for mapping orthography to phonology directly. The main effect of spelling transparency along with other lexico-semantic variables (such as frequency, imageability and AoA on word naming suggests an interaction between these routes (Bi, Han, Weekes, & Shu, 2007; Hillis & Caramazza, 1995, which makes the word naming less challenging than the picture naming task for most speakers with aphasia. However, the result from case 5 could suggest that the direct route for reading can be selectively impaired. Moreover, the mild effect of spelling transparency on picture naming even after other lexico-semantic variables (e.g. AoA, frequency, imageability, name agreement, imageability, and word length have been explained, indicates that objects with more transparent spellings have a greater probability of being named accurately in aphasia. This finding raises the possibility that orthographic representations are activated to some degree during picture naming to help access the phonology of the word as long as the spelling of the word is transparent. This explanation is compatible with the summation account of lexical access in aphasia (Hillis & Caramazza, 1995.

  9. Mobile Technology in E-Learning for Undergraduate Medical Education on Emergent Otorhinolaryngology-Head and Neck Surgery Disorders: Pilot Randomized Controlled Trial.

    Science.gov (United States)

    Lee, Li-Ang; Wang, Shu-Ling; Chao, Yi-Ping; Tsai, Ming-Shao; Hsin, Li-Jen; Kang, Chung-Jan; Fu, Chia-Hsiang; Chao, Wei-Chieh; Huang, Chung-Guei; Li, Hsueh-Yu; Chuang, Cheng-Keng

    2018-03-08

    (difference 1.7, 95% CI 0.1-2.7; P=.03), and hedonic stimulation (difference 1.9, 95% CI 0.3-3.1; P=.01) compared with the PPS group. Qualitative feedback indicated that the various games in the IM module attracted the participants' attention but that the nonlinearly arranged materials affected their learning. Using M-TEL for undergraduate medical education on emergent ORL-HNS disorders, an IM module seems to be useful for gaining knowledge, but competency may need to occur elsewhere. While the small sample size reduces the statistical power of our results, its design seems to be appropriate to determine the effects of M-TEL using a larger group. ClinicalTrials.gov NCT02971735; https://clinicaltrials.gov/ct2/show/NCT02971735 (Archived by WebCite at http://www.webcitation.org/6waoOpCEV). ©Li-Ang Lee, Shu-Ling Wang, Yi-Ping Chao, Ming-Shao Tsai, Li-Jen Hsin, Chung-Jan Kang, Chia-Hsiang Fu, Wei-Chieh Chao, Chung-Guei Huang, Hsueh-Yu Li, Cheng-Keng Chuang. Originally published in JMIR Medical Education (http://mededu.jmir.org), 08.03.2018.

  10. Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway

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    He JL

    2014-12-01

    Full Text Available Jin-Lian He,1 Zhi-Wei Zhou,2,3 Juan-Juan Yin,2 Chang-Qiang He,1 Shu-Feng Zhou,2,3 Yang Yu1 1College of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, Guizhou, People’s Republic of China Abstract: Drug metabolizing enzymes (DMEs and drug transporters are regulated via epigenetic, transcriptional, posttranscriptional, and translational and posttranslational modifications. Phase I and II DMEs and drug transporters play an important role in the disposition and detoxification of a large number of endogenous and exogenous compounds. The nuclear factor (erythroid-derived 2-like 2 (Nrf2 is a critical regulator of a variety of important cytoprotective genes that are involved in disposition and detoxification of xenobiotics. Schisandra chinensis (SC is a commonly used traditional Chinese herbal medicine that has been primarily used to protect the liver because of its potent antioxidative and anti-inflammatory activities. SC can modulate some DMEs and drug transporters, but the underlying mechanisms are unclear. In this study, we aimed to explore the role of Nrf2 in the regulatory effect of SC extract (SCE on selected DMEs and drug transporters in human hepatocellular liver carcinoma cell line (HepG2 cells. The results showed that SCE, schisandrin A, and schisandrin B significantly increased the expression of NAD(PH: Nicotinamide Adenine Dinucleotide Phosphate-oxidase or:quinone oxidoreductase 1, heme oxygenase-1, glutamate–cysteine ligase, and glutathione S-transferase A4 at both transcriptional and posttranscriptional levels. Incubation of HepG2 cells with SCE resulted in a significant

  11. Isotopic Investigations of Nebular and Parent Body Processes with a High Sensitivity Ion Microprobe

    Science.gov (United States)

    McKeegan, Kevin D.

    2005-01-01

    NASA supported the development of the CAMECA ims 1270 ion microprobe at UCLA for applications in cosmochemistry. The primary investigations centered on measuring the microscopic distributions of key isotopic abundances in primitive meteoritic materials as a means of constraining the nature of important thermal and chemical processes in the solar nebula and the timescales associated with those processes. Our prior work on oxygen isotope anomalies in a wide variety of meteoritic materials had led us to a view of a spatially heterogeneous nebula, and in particular, a restricted region for CAI formation that is characterized by O-16-rich gas. Because of its production of CAIs in the energetic local environment near the protosun, the existence of a natural transport mechanism via bipolar outflows, and a general astrophysical plausibility, we were attracted to the fluctuating X-wind model which had been put forward by Frank Shu, Typhoon Lee, and colleagues. With our collaborators, we undertook a series of investigations to test the viability of this hypothesis; this work led directly to the discovery of live Be in CAIs and a clear demonstration of the existence of 160-rich condensates, which necessarily implies an O-16-rich gaseous reservoir in the nebula. Both of these observations fit well within the context of X-wind type models, i.e. formation of CAIs (or condensation of their precursors) in the reconnection ring sunward of the inner edge of the accretion disk, however much work remains to be done to test whether the physical parameters of the model can quantitatively predict not only the thermal histories of CAIs but also their radioactivity. The issue of spatial heterogeneity in the nebula, central to the X-wind model, is also at the heart of any chronology based on short-lived radioisotopes. In this work, we followed up on strong hints for presence of exireme:j: (53 day) short-lived Be-7, and have prepared a manuscript (in revision). We also measured A1-Mg

  12. PREFACE: International Conference on Fundamentals and Applications of HIPIMS

    Science.gov (United States)

    Ehiasarian, Arutiun; Bandorf, Ralf

    2012-09-01

    Thin film technology and surface engineering are nowadays key components for numerous innovative products like efficient windows, flat screens, sensors or hard coatings used in tool coating and automotive applications, as well as products for everyday life. In line with the demands of surface technology, coating technology is also evolving and improving. The latest major technology jump was the introduction of pulse technology in physical vapor deposition. High power impulse magnetron sputtering is the most recent development of pulse sputtering. After approximately a decade of intense academic investigation and development we observe today a transfer of this new technology towards industrial processes. As well as several international activities the international conference on fundamentals and applications of HIPIMS continues the success story of the HIPIMS days, initiated in 2004 at Sheffield Hallam University, UK. Becoming the only international conference especially dedicated to HIPIMS the HIPIMS conference is a venue for industrial and academic exchange on the latest developments in this fast evolving new technology. As a joint undertaking of Sheffield Hallam University SHU, Network of Competence for Industrial Plasma Surface Technology INPLAS and Fraunhofer Institute for Surface Engineering and Thin Films IST the HIPIMS conference was launched in 2010 in Sheffield, UK. With 120 delegates the impact of the new conference was underlined. The growing importance of HIPIMS technology was connected with a growth by nearly 35% to 160 participants in 2011 at the second HIPIMS conference in Braunschweig, DE. The participants were made up of equal numbers from research and development (university and research institutes) and industry. Being a global conference representatives from 25 different countries from all continents attended. The HIPIMS conference is also in joint collaboration with the COST Action MP0804 Highly Ionized Pulse Plasma Processes (www

  13. A study on the hemocompatibility of dendronized chitosan derivatives in red blood cells

    Directory of Open Access Journals (Sweden)

    Zhou YF

    2015-05-01

    Full Text Available Yanfang Zhou,1,* Jiemei Li,1,* Fang Lu,1 Junjie Deng,2 Jiahua Zhang,1 Peijie Fang,1 Xinsheng Peng,1 Shu-Feng Zhou3 1Guangdong Medical Universtity, Dongguan, Guangdong, People’s Republic of China; 2Department of Materials Science and Engineering, Drexel University, Philadelphia, PA, USA; 3Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA *These authors contributed equally to this work Abstract: Dendrimers are hyperbranched macromolecules with well-defined topological structures and multivalent functionalization sites, but they may cause cytotoxicity due to the presence of cationic charge. Recently, we have introduced alkyne-terminated poly(amidoamine (PAMAM dendrons of different generations (G=2,3 into chitosan to obtain dendronized chitosan derivatives [Cs-g-PAMAM (G=2,3], which exhibited a better water solubility and enhanced plasmid DNA transfection efficiency. In this study, we attempted to examine the impact of Cs-g-PAMAM (G=2,3 at different concentrations (25 µg/mL, 50 µg/mL, and 100 µg/mL on the morphology, surface structure, and viability of rat red blood cells (RBCs. The results showed that treatment of RBCs with Cs-g-PAMAM (G=2,3 at 50 µg/mL and 100 µg/mL induced a slightly higher hemolysis than Cs, and Cs-g-PAMAM (G=3 caused a slightly higher hemolysis than Cs-g-PAMAM (G=2, but all values were <5.0%. Optical microscopic and atomic force microscopic examinations indicated that Cs-g-PAMAM (G=2,3 caused slight RBC aggregation and lysis. Treatment of RBCs with 100 µg/mL Cs-g-PAMAM (G=3 induced echinocytic transformation, and RBCs displayed characteristic irregular contour due to the folding of the periphery. Drephanocyte-like RBCs were observed when treated with 100 µg/mL Cs-g-PAMAM (G=3. Erythrocytes underwent similar shape transition upon treatment with Cs-g-PAMAM (G=2 or Cs. The roughness values (Rms of RBCs incubated with Cs-g-PAMAM (G=2,3 were significantly larger

  14. A comparative study of three ternary complexes prepared in different mixing orders of siRNA/redox-responsive hyperbranched poly (amido amine/hyaluronic acid

    Directory of Open Access Journals (Sweden)

    Chen CJ

    2012-07-01

    Full Text Available Cheng-Jun Chen,1 Zhi-Xia Zhao,1 Jian-Cheng Wang,1 En-Yu Zhao,1 Ling-Yan Gao,1 Shu-Feng Zhou,2 Xiao-Yan Liu,1 Wan-Liang Lu,1 Qiang Zhang11State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmaceutics, School of Pharmaceutical Science, Peking University, Beijing, People’s Republic of China; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USAAbstract: In this study, a novel redox-responsive hyperbranched poly(amido amine (named PCD was synthesized and used as a cationic polymer to form a ternary complex with small interfering RNA (siRNA and hyaluronic acid (HA for siRNA delivery. Here, it is hypothesized that different mixing orders result in different assembly structures, which may affect the siRNA delivery efficiency. To investigate the effects of mixing orders on siRNA delivery efficiency in two human breast cancer cell lines, three ternary complexes with different mixing orders of siRNA/PCD/HA were prepared and characterized: mixing order I (initially prepared siRNA/PCD binary complex further coated by negatively charged HA, mixing order II (initially prepared HA/PCD binary complex further incubated with siRNA, and mixing order III (initially prepared siRNA/HA mixture further electrostatically compacted by positively charged PCD. With an optimized siRNA/PCD/HA charge ratio of 1/20/16, the particle sizes and zeta potentials of these ternary complexes were 124.8 nm and 27.3 mV (mixing order I, 147.5 nm and 29.9 mV (mixing order II, and 128.8 nm and 19.4 mV (mixing order III. Also, the effects on stability, cellular uptake, and gene silencing efficiency of siRNA formulated in ternary complexes with different mixing orders were investigated. The results showed that mixing orders I and III displayed better siRNA transfection and protection than mixing order II in human breast cancer MCF-7 and MDA-MB-231 cells. More interesting, at the siRNA/PCD/HA charge ratio of 1/20/16, the

  15. Primary care physician perceptions on the diagnosis and management of chronic obstructive pulmonary disease in diverse regions of the world

    Directory of Open Access Journals (Sweden)

    Aisanov Z

    2012-04-01

    Full Text Available Zaurbek Aisanov1,*, Chunxue Bai2,*, Otto Bauerle3,*, Federico D Colodenco4,*, Charles Feldman5,6,*, Shu Hashimoto7,*, Jose Jardim8,*, Christopher KW Lai9,*, Rafael Laniado-Laborin10,*, Gilbert Nadeau11,*, Abdullah Sayiner12,*, Jae Jeong Shim13,*, Ying Huang Tsai14,*, Richard D Walters11,*, Grant Waterer15,* 1Pulmonology Research Institute, Moscow, Russia; 2Department of Pulmonary Medicine, Fudan University, Shanghai, People's Republic of China; 3Centro Médico de las Américas, Mérida, Yucatán, Mexico; 4Hospital de Rehabilitación Respiratoria "María Ferrer," Buenos Aires, Argentina; 5Department of Internal Medicine, Charlotte Maxeke Johannesburg Hospital, Johannesburg, South Africa; 6Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 7Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan; 8Federal University of São Paulo, São Paulo, Brazil; 9Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, People's Republic of China; 10Faculty of Medicine, Universidad Autónoma de Baja California, Tijuana, Baja California, Mexico; 11Medical Affairs, GlaxoSmithKline, Brentford, UK; 12Department of Chest Diseases, Ege University Medical School, Izmir, Turkey; 13Department of Pulmonology, Guro Hospital, Korea University Medical Center, Seoul, South Korea; 14Department of Respiratory Care Medicine, Chang Gung Memorial Hospital, Chia-Yi, Taiwan; 15School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia*ICON group (International COPD Network, listed in alphabetical orderAbstract: Chronic obstructive pulmonary disease (COPD is a multicomponent disorder that leads to substantial disability, impaired quality of life, and increased mortality. Although the majority of COPD patients are first diagnosed and treated in primary care practices, there is comparatively little

  16. Co-expression of periostin and EGFR in patients with esophageal squamous cell carcinoma and their prognostic significance

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    Jia W

    2016-08-01

    Full Text Available Wei Jia,1 Wei Wang,1 Chu-shu Ji,1 Jun-yang Niu,2 Ya-jing Lv,1 Hang-cheng Zhou,2 Bing Hu1 1Department of Medical Oncology, 2Department of Pathology, Anhui Provincial Hospital, Anhui Medical University, Hefei, People’s Republic of China Background: Both periostin (PN and epidermal growth factor receptor (EGFR can predict the prognosis of several carcinomas alone. However, coexpression of PN and EGFR in esophageal squamous cell carcinoma (ESCC still remains unknown. We aimed to clarify their relationship with clinicopathological factors and prognostic significance of their coexpression in ESCC. Patients and methods: In this single-center retrospective study, immunohistochemistry was performed to evaluate the expression of PN and EGFR in ESCC and paracarcinomatous tissues of 83 patients. The quantitative expression levels of PN and EGFR were examined in two ESCC and tumor-adjacent tissues. The levels of PN and EGFR expression were correlated with clinicopathological parameters by the χ2 or Kruskal–Wallis method. Spearman’s rank correlation test was performed to determine the relationship between PN and EGFR expression levels. Kaplan–Meier and Cox regression analyses were used to detect the prognostic factors of disease-free survival (DFS and overall survival (OS. Results: The high expression of PN protein in ESCC tissues was significantly associated with tumor length (P=0.044, differentiation grade (P=0.003, venous invasion (P=0.010, invasion depth (P=0.007, lymphatic metastasis (P=0.000, and tumor stage (P=0.000. The high expression of EGFR protein in ESCC tissues was only significantly related to lymphatic metastasis (P=0.000, invasion depth (P=0.022, and tumor stage (P=0.000. Kaplan–Meier analysis showed that high expression of PN was closely correlated to reduced OS (P=0.000 and DFS (P=0.000, which was consistent with EGFR expression. Cox regression analysis identified PN and EGFR as independent poor prognostic factors of OS and DFS

  17. Partial stereotactic ablative boost radiotherapy in bulky non-small cell lung cancer: a retrospective study

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    Bai Y

    2018-05-01

    Full Text Available Yun Bai,1 Xian-shu Gao,1 Shang-bin Qin,1 Jia-yan Chen,1 Meng-meng Su,1 Qing Liu,2 Xiu-bo Qin,2 Ming-wei Ma,1 Bo Zhao,1 Xiao-bin Gu,1 Mu Xie,1 Ming Cui,1 Xin Qi,1 Xiao-ying Li1 1Department of Radiation Oncology, Peking University First Hospital, Beijing, China; 2Department of Medical Imaging, Peking University First Hospital, Beijing, China Purpose: Bulky non-small cell lung cancer (NSCLC is difficult to achieve effective local control by conventionally fractionated radiotherapy (CRT. The present work aims to evaluate the safety and efficacy of partial stereotactic ablative boost radiotherapy (P-SABR in bulky NSCLC. Patients and methods: From December 2012 through August 2017, 30 patients with bulky NSCLC treated with P-SABR technique were analyzed. The P-SABR plan consisted of one partial SABR plan (5–9 Gy/f, 3–6 fractions to gross tumor boost (GTVb, followed by one CRT plan to the planning target volume (PTV. GTVb was the max volume receiving SABR to guarantee the dose of organs-at-risks (OARs falloff to about 3 Gy/f. The total dose of PTV margin was planned to above 60 Gy. The simply CRT plans were created using the same planning parameters as the original plan, with the goal to achieve comparable OARs doses and PTV margin dose to the P-SABR plan. Dosimetric variables were acquired in both P-SABR and compared CRT plans. Toxicity, local control, and survival were also evaluated. Results: Median follow-up in survivors was 10.3 months (range=2.3–39.4 months. Eleven patients (36.7% had partial response (PR and ten patients (33.3% had stable disease (SD. Two-year overall survival was 55.6%. Two-year local control rate was 85.7%. No severe acute side effects .CTCAE Grade III were observed. Compared to the simply CRT plan, P-SABR plans achieved similar doses to the OARs and Dmin, but increased dose at the isocenter, Dmean, Dmax, and biological equivalent dose (BED significantly (P<0.05. BED in the tumor center could reach 107.3 Gy (93.2–132

  18. Coffee and caffeine potentiate the antiamyloidogenic activity of melatonin via inhibition of Aβ oligomerization and modulation of the Tau-mediated pathway in N2a/APP cells

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    Zhang LF

    2014-12-01

    Full Text Available Li-Fang Zhang,1,2 Zhi-Wei Zhou,2 Zhen-Hai Wang,1 Yan-Hui Du,1 Zhi-Xu He,3 Chuanhai Cao,2 Shu-Feng Zhou2,31Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2Department of Pharmaceutical Science, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, Guizhou, People’s Republic of ChinaAbstract: There is an increasing prevalence of Alzheimer’s disease (AD, which has become a public health issue. However, the underlying mechanisms for the pathogenesis of AD are not fully understood, and the current therapeutic drugs cannot produce acceptable efficacy in AD patients. Previous animal studies have shown that coffee (Coff, caffeine (Caff, and melatonin (Mel have beneficial effects on AD. Disturbed circadian rhythms are observed in AD, and chronotherapy has shown promising effects on AD. In this study, we examined whether a combination of Coff or Caff plus Mel produced a synergistic/additive effect on amyloid-ß (Aß generation in Neuro-2a (N2a/amyloid precursor protein (APP cells and the possible mechanisms involved. Cells were treated with Coff or Caff, with or without combined Mel, with three different chronological regimens. In regimen 1, cells were treated with Coff or Caff for 12 hours in the day, followed by Mel for 12 hours in the night. For regimen 2, cells were treated with Coff or Caff plus Mel for 24 hours, from 7 am to 7 am the next day. In regimen 3, cells were treated with Coff or Caff plus Mel with regimen 1 or 2 for 5 consecutive days. The extracellular Aβ40/42 and Aβ oligomer levels were determined using enzyme-linked immunosorbent assay (ELISA kits. The expression and/or phosphorylation levels of glycogen synthase kinase 3β (GSK3β, Erk1/2, PI3K

  19. Electropuncture influences on learning, memory, and neuropeptide expression in a rat model of vascular dementia

    Institute of Scientific and Technical Information of China (English)

    Ying Shao; Yanqian Fu; Lihua Qiu; Bing Yan; Xinsheng Lai; Chunzhi Tang

    2008-01-01

    BACKGROUND: Studies in recent years have indicated that several neuropeptide-like substances, such as arginine vasopressin (AVP), somatostatin (SS), and β-endorphine (β-EP), are involved in the process of cerebral ischemic damage to cranial nerves.OBJECTIVE: To observe the effects of electropuncture on back-shu points, as well as the influence on learning and memory, AVP, SS, and β-EP levels in plasma and brain were measured in a rat model of vascular dementia (VD). DESIGN: Randomized controlled trial.SETTING: College of Acupuncture and Massage of Guangzhou University of Chinese Medicine.MATERIALS: This experiment was performed at the Animal Experiment Center of Guangzhou University of TCM from December 2005 to December 2006. A total of 48 healthy adult male Sprague Dawley rats of SPF-grade, 180-220 g, were provided by The Animal Experiment Center of Guangzhou University of Traditional Chinese Medicine. The following instruments were used: SDQ-30 Dipolar Radio-frequency Electrocoagulator (Shanghai Operation Instrument Factory), Morris Water Maze (The Animal Experiment Center of Guangzhou University of Traditional Chinese Medicine), Type G6805-1 Treating Equipment (Huasheng Equipment Factory, Qingdao, China).METHODS: ① Eight rats were randomly selected for the control group; the remaining 40 rats underwent 4-vascular occlusion to establish a cerebral ischemia model. Due to the death of 13 rats and 2 hemiplegies during model establishment, there was a total of 25 model rats available for testing. The model rats were divided randomly into 3 groups according to their body weight: electropuncture group (n = 9), medication group (n = 8), and VD group (n = 8). ② Electropuncture group: 25 mm needles (28 gauge) were used to electropuncture (150 Hz, continuous waves, 1.0-2.0 mA, duration of 20 minutes) the following acupoints: Baihui (GV20), Geshu (BL17), Pishu (BL20), and Shenshu (BL23). The acupoints were located according to Experimental acupuncturology and were

  20. A search for strong, ordered magnetic fields in Herbig Ae/Be stars

    Science.gov (United States)

    Wade, G. A.; Bagnulo, S.; Drouin, D.; Landstreet, J. D.; Monin, D.

    2007-04-01

    Be stars is about 200 G, similar to that of Ap stars and consistent with magnetic flux conservation during stellar evolution. These results are all in agreement with the hypothesis that the magnetic fields of main-sequence Ap/Bp stars are fossils, which already exist within the stars at the PMS stage. Finally, we explore the ability of our new magnetic data to constrain magnetospheric accretion in Herbig Ae/Be stars, showing that our magnetic data are not consistent with the general occurrence in HAeBe stars of magnetospheric accretion as described by the theories of Königl and Shu et al.. Based on observations from the ESO telescopes at the La Silla Paranal Observatory under programme ID 072.C-0447, DDT-272.C-5063, 074.C-0442. E-mail: wade-g@rmc.ca

  1. Effects of combined dietary supplementation with fenofibrate and Schisandrae Fructus pulp on lipid and glucose levels and liver function in normal and hypercholesterolemic mice

    Directory of Open Access Journals (Sweden)

    Zhu PL

    2015-02-01

    Full Text Available Pei-Li Zhu,1 Si-Yuan Pan,1 Shu-Feng Zhou,2 Yi Zhang,1 Xiao-Yan Wang,1 Nan Sun,1 Zhu-Sheng Chu,1 Zhi-Ling Yu,3 Kam-Ming Ko41Department of Pharmacology, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, People’s Republic of China; 4Division of Life Science, Hong Kong University of Science and Technology, Hong Kong, People’s Republic of ChinaBackground: Currently, combined therapy using herbs and synthetic drugs has become a feasible therapeutic intervention against some diseases. The purpose of this study was to assess the effects of supplementation with fenofibrate (FF, a chemical drug used for the treatment of hyperlipidemia, and the aqueous extract of Schisandrae Fructus (SF, a Chinese herb pulp (AqSF-P or an SF-related synthetic analog, bicyclol (BY, on serum/hepatic lipid levels and liver status in normal and hypercholesterolemic (HCL mice.Methods: Male mice obtained from the Institute of Cancer Research (ICR were fed on a normal diet (ND or high cholesterol/bile salt (0.5%/0.15%, w/w diet (HCBD containing FF (0.03% or 0.1%, w/w with or without AqSF-P (0.3%-9.0%, based on crude herbal material, w/w or BY (0.025%, w/w for 10 days. Then serum lipid levels and alanine aminotransferase (ALT activity, as well as hepatic triglyceride (TG, total cholesterol (TC, and glucose levels, were measured.Results: Oral supplementation with FF significantly reduced serum and hepatic TG, TC, and hepatic glucose levels (approximately 79% in mice fed with ND or HCBD. FF supplementation combined with AqSF-P or BY increased FF-induced reduction in hepatic TC and TG contents in ND-fed mice (up to 67% and in HCBD-fed mice (up to 54%, when compared with FF supplementation alone. Hepatic glucose-lowering effect of FF was

  2. Low bone mineral density in COPD patients with osteoporosis is related to low daily physical activity and high COPD assessment test scores

    Directory of Open Access Journals (Sweden)

    Liu WT

    2015-09-01

    Full Text Available Wen-Te Liu,1,2,* Han-Pin Kuo,3,* Tien-Hua Liao,4 Ling-Ling Chiang,1 Li-Fei Chen,3 Min-Fang Hsu,5 Hsiao-Chi Chuang,1 Kang-Yun Lee,2,6 Chien-Da Huang,3 Shu-Chuan Ho11School of Respiratory Therapy, College of Medicine, Taipei Medical University, 2Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, 3Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 4Department of Respiratory Therapy, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, 5Department of Healthcare Administration, Asia University, Wufeng, Taichung, 6Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan*These authors contributed equally to this workAbstract: COPD patients have an increased prevalence of osteoporosis (OP compared with healthy people. Physical inactivity in COPD patients is a crucial risk factor for OP; the COPD assessment test (CAT is the newest assessment tool for the health status and daily activities of COPD patients. This study investigated the relationship among daily physical activity (DPA, CAT scores, and bone mineral density (BMD in COPD patients with or without OP. This study included 30 participants. Ambulatory DPA was measured using actigraphy and oxygen saturation by using a pulse oximeter. BMD was measured using dual-energy X-ray absorptiometry. OP was defined as a T-score (standard deviations from a young, sex-specific reference mean BMD less than or equal to -2.5 SD for the lumbar spine, total hip, and femoral neck. We quantified oxygen desaturation during DPA by using a desaturation index and recorded all DPA, except during sleep. COPD patients with OP had lower DPA and higher CAT scores than those of patients without OP. DPA was significantly positively correlated with (lumbar spine, total hip, and femoral neck BMD (r=0.399, 0.602, 0.438, respectively

  3. An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides

    Directory of Open Access Journals (Sweden)

    Cheng J

    2014-12-01

    Full Text Available Jiang Cheng,1,2 Zhi-Wei Zhou,2 Hui-Ping Sheng,3 Lan-Jie He,4 Xue-Wen Fan,1 Zhi-Xu He,5 Tao Sun,6 Xueji Zhang,7 Ruan Jin Zhao,8 Ling Gu,9 Chuanhai Cao,2 Shu-Feng Zhou2,5 1Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2Department of Pharmaceutical Science, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Department of Infectious Diseases, 4Department of Endocrinology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 5Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, Guizhou, 6Key Laboratory of Craniocerebral Diseases of Ningxia Hui Autonomous Region, Ningxia Medical University, Yinchuan, Ningxia, 7Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, People’s Republic of China; 8Center for Traditional Chinese Medicine, Sarasota, FL, USA; 9School of Biology and Chemistry, University of Pu’er, Pu’er, Yunnan, People’s Republic of China Abstract: Lycium barbarum berries, also named wolfberry, Fructus lycii, and Goji berries, have been used in the People’s Republic of China and other Asian countries for more than 2,000 years as a traditional medicinal herb and food supplement. L. barbarum polysaccharides (LBPs are the primary active components of L. barbarum berries and have been reported to possess a wide array of pharmacological activities. Herein, we update our knowledge on the main pharmacological activities and possible molecular targets of LBPs. Several clinical studies in healthy subjects show that consumption of wolfberry juice improves general wellbeing and immune functions. LBPs are reported to have antioxidative and antiaging properties in different models. LBPs show antitumor activities against various types of

  4. NIMS and Empa announce STAM collaboration

    Science.gov (United States)

    Yoshida, Toyonobu; Krug, Harald F.

    2014-02-01

    In January 2014, the Swiss Federal Laboratories for Materials Science and Technology (Empa) joined the National Institute for Materials Science (NIMS) in collaborative activities on Science and Technology of Advanced Materials (STAM). STAM was founded in 2000. In 2005 NIMS took over the management of its peer review and financial systems, resulting in a continuous rise of the impact of the journal. Empa will provide further support for the editorial management of STAM. In particular, it will establish a European office in Switzerland and reinforce the Editorial Board. From this point of view, I am pleased and excited to have new colleagues from Empa on our Editorial Board, and I believe that this collaboration will bring us a remarkable improvement in the international visibility of STAM and increase the number of paper submissions from Europe. It will expand the topics covered in the journal from traditional fields of materials science with a focus on energy and environmental issues to medical and bioengineering applications, where Empa has a significant expertise. I firmly believe that Empa's participation in publishing STAM will reinforce its position as an open-access journal with a global audience. Together with my colleagues, Yoshio Sakka (NIMS) and Shu Yamaguchi (University of Tokyo), I welcome Harald F Krug as the new Co-Editor-in-Chief of STAM. I am also pleased to learn that the year 2014 not only marks the 15th anniversary of STAM, but also the 150th anniversary of the establishment of diplomatic relations between Japan and Switzerland. Toyonobu Yoshida Advances in materials science are key for the sustainable development of our society. That is why, starting from January 2014, Empa, the Swiss Federal Laboratories for Materials Science and Technology, have engaged in an entirely new field of activity: scientific publishing. As mentioned above, Empa joined NIMS in the publishing of STAM. We have a clear-cut goal in mind: we want to support our sister

  5. Can machine learning complement traditional medical device surveillance? A case-study of dual-chamber implantable cardioverter–defibrillators

    Directory of Open Access Journals (Sweden)

    Ross JS

    2017-08-01

    Full Text Available Joseph S Ross,1–4 Jonathan Bates,4 Craig S Parzynski,4 Joseph G Akar,4,5 Jeptha P Curtis,4,5 Nihar R Desai,4,5 James V Freeman,4,5 Ginger M Gamble,4 Richard Kuntz,6 Shu-Xia Li,4 Danica Marinac-Dabic,7 Frederick A Masoudi,8 Sharon-Lise T Normand,9,10 Isuru Ranasinghe,11 Richard E Shaw,12 Harlan M Krumholz2–5 1Section of General Medicine, Department of Medicine, 2Robert Wood Johnson Foundation Clinical Scholars Program, Yale School of Medicine, 3Department of Health Policy and Management, Yale School of Public Health, 4Center for Outcomes Research and Evaluation, Yale–New Haven Hospital, 5Section of Cardiovascular Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT, 6Medtronic Inc, Minneapolis, MN, 7Division of Epidemiology, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, 8Division of Cardiology, Department of Medicine, University of Colorado, Aurora, CO, 9Department of Health Care Policy, Harvard Medical School, 10Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, USA; 11Discipline of Medicine, University of Adelaide, Adelaide, SA, Australia; 12Department of Clinical Informatics, California Pacific Medical Center, San Francisco, CA, USA Background: Machine learning methods may complement traditional analytic methods for medical device surveillance.Methods and results: Using data from the National Cardiovascular Data Registry for implantable cardioverter–defibrillators (ICDs linked to Medicare administrative claims for longitudinal follow-up, we applied three statistical approaches to safety-signal detection for commonly used dual-chamber ICDs that used two propensity score (PS models: one specified by subject-matter experts (PS-SME, and the other one by machine learning-based selection (PS-ML. The first approach used PS-SME and cumulative incidence (time-to-event, the second approach used PS-SME and cumulative risk (Data Extraction and

  6. Book Reviews

    Directory of Open Access Journals (Sweden)

    R.A. Römer

    1963-10-01

    Full Text Available - A.J.C. Lach de Bére, Fernand van Langenhove, Consciences Tribales et Nationales en Afrique Noire. Institut Royal des Relations Internationales, Bruxelles. Martinus Nijhoff, ‘s-Gravenhage, 1960; 444 blz. - J.H. Scherer, A.H.J. Prins, The Swahili-speaking peoples of Zanzibar and the E. African Coast (Arabs, Shirazi and Swahili. Ethnographic Survey of Africa: East Central Africa, part XII. Uitgave van het International African Institute, London, 1961. 143 pp., m. kaart. - P. Driessens, Carol Brubaker, Geesten van het woud. Servire Luxe Pockets nr. 66. Servire, Den Haag 1963. 175 pp., 24 foto’s. - Joh. J. Hanrath, Indonesian Economics. The concept of dualism in theory and policy. Den Haag (W. van Hoeve 1961. 443 pp. - W. Ph. Coolhaas, H.R.C. Wright, East-Indian economic problems of the age of Cornwallis and Raffles. Luzac, London, 1961; 271 pp. - H.J. de Graaf, M.A.P. Meilink-Roelofsz, Asian trade and European influence in the Indonesian Archipelago between 1500 and about 1630. Academisch Proefschrift Amsterdam (S.U.. M. Nijhoff, ‘s-Gravenhage 1962. 471 pp. - Logemann, Herbert Feith, The decline of constitutional democracy in Indonesia. Cornell University Press, Ithaca, New York, 1962. XX en 608 blz. - F.D.K. Bosch, G. Coedés, Les peuples de la péninsule indochinoise. 228 pp., 16 pl., 1 carte; Ed. Dunod, Paris, 1962. - L. Sluimers, Sirdar Ikbal Ali Shah, Viet-nam. London, Octagon Press, 1960. XV, 232 blz., krt. - L. Sluimers, J.G. Keyes, A bibliography of North Vietnamese Publications in the Cornell University Library. Ithaca, Cornell University, 1962. Data paper: Number 47. Southeast Asia Program. Department of Asian Studies. Cornell University. X, 116 blz., X. - A.F.P. Hulsewé, G.P. Oery, The Man-Shu (Book of the Southern Barbarians, translated by Gordon H. Luce, edited by G.P. Oery; Data Paper Nr. 44, Southeast Asia Program, Dept. of Far Eastern Studies, Cornell Univ., Ithaca, N.Y.; 1961. (X + 116 pp., 1 map. - C.H.M. Palm, Felix M

  7. Mid-arm and calf circumferences are stronger mortality predictors than body mass index for patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Ho SC

    2016-08-01

    Full Text Available Shu-Chuan Ho,1,2 Jiun-Yi Wang,3,4 Han-Pin Kuo,5 Chien-Da Huang,5 Kang-Yun Lee,2,6 Hsiao-Chi Chuang,1,2 Po-Hao Feng,2,6 Tzu-Tao Chen,2,* Min-Fang Hsu7,* 1School of Respiratory Therapy, College of Medicine, 2Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, 3Department of Healthcare Administration, Asia University, Wufeng, 4Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, 5Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 6Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, 7Department of Nursing, Yuanpei University of Medical Technology, Hsinchu City, Taiwan *These authors contributed equally to this work Background: Chronic obstructive pulmonary disease (COPD is currently the third most common cause of death in the world. Patients with COPD experience airflow obstruction, weight loss, skeletal muscle dysfunction, and comorbidities. Anthropometric indicators are risk factors for mortality in geriatric assessment. Purpose: This study examined and compared the associations of anthropometric indicators, such as low body mass index (BMI, low mid-arm circumference (MAC, and low calf circumference (CC, with the prediction of a 3-year follow-up mortality risk in patients with COPD. Methods: We recruited nonhospitalized patients with COPD without acute conditions from a general hospital in Taiwan. The BMI, MAC, and CC of all patients were measured, and they were followed for 3 years through telephone interviews and chart reviews. The Kaplan–Meier survival curves stratified by BMI, MAC, and CC were analyzed. Variables univariately associated with survival were entered into a multivariate Cox regression model. The Bayesian information criterion was used to compare the predictive ability of the three anthropometric

  8. Medication adherence in patients with psychotic disorders: an observational survey involving patients before they switch to long-acting injectable risperidone

    Directory of Open Access Journals (Sweden)

    Baylé FJ

    2015-09-01

    Full Text Available Franck Jean Baylé,1 Arnaud Tessier,2,3 Sophie Bouju,4 David Misdrahi2,3 1Sainte-Anne Hospital (SHU, Paris V-Descartes University, Paris, 2Hôpital Charles Perrens, Pôle de Psychiatrie Adulte, 3CNRS UMR 5287-INCIA, Bordeaux University, Bordeaux, 4Janssen-Cilag France, Issy Les Moulineaux, Paris, France Background: Maintaining antipsychotic therapy in psychosis is important in preventing relapse. Long-acting depot preparations can prevent covert non-adherence and thus potentially contribute to better patient outcomes. In this observational survey the main objective is to evaluate medication adherence and its determinants for oral treatment in a large sample of patients with psychosis.Methods: In this cross-sectional survey medication adherence for oral treatment was assessed by patients using the patient-rated Medication Adherence Questionnaire (MAQ. Data were collected by physicians on patients with a recent acute psychotic episode before switching to long-acting injectable risperidone. Other evaluations included disease severity (Clinical Global Impression – Severity, patients’ insight (Positive and Negative Syndrome Scale item G12, treatment acceptance (clinician-rated Compliance Rating Scale, and therapeutic alliance (patient-rated 4-Point ordinal Alliance Scale.Results: A total of 399 psychiatrists enrolled 1,887 patients (mean age 36.8±11.9 years; 61.6% had schizophrenia. Adherence to oral medication was “low” in 53.2% of patients, “medium” in 29.5%, and “high” in 17.3%. Of patients with psychiatrist-rated active acceptance of treatment, 70% had “medium” or “high” MAQ scores (P<0.0001. Medication adherence was significantly associated with therapeutic alliance (4-Point ordinal Alliance Scale score; P<0.0001. Patient age was significantly associated with adherence: mean age increased with greater adherence (35.6, 36.7, and 38.6 years for patients with “low”, “medium”, and “high” levels of adherence

  9. PREFACE: Preface

    Science.gov (United States)

    Audoin, Bertrand; Dehoux, Thomas; Guillet, Yannick

    2011-02-01

    and the gala dinner took place in a wine chateau in the medieval village. We hope this experience will remain in the attendees' memories as a pleasant and convivial time. We would like to express our thanks to the members of the organizing committee, the scientific committee, and all our generous sponsors, either institutions or companies, for their help in making this event possible. We would also like to thank the scientists involved for their confidence in our organization, and for their contributions. As unanimously decided by the attendees, the next symposium will be held in Japan, most likely in 2012. The papers published in this volume of the Journal of Physics: Conference Series provide a collection of state-of-the-art and recent advances in research and applications of laser ultrasonics as presented at this second Symposium. Bertrand Audoin - Conference ChairThomas Dehoux - Conference proceedings co-editorYannick Guillet - Conference proceedings co-editor Conference photograph Scientific committee Bertrand AudoinUniversité Bordeaux 1, France Alain BlouinNRC, Canada Christ GlorieuxKatholieke Universiteit Leuven, Belgium Vitalyi GusevUniversité du Maine, France Peter HessUniversity of Heidelberg, Germany Alexander A KarabutovMoscow State University, Russia Sridhar KrishnaswamyNorthwestern University, USA Humphrey MarisBrown University, USA Jean-Pierre MonchalinNRC, Canada Todd MurrayBoston University, USA Makoto OchiaiToshiba Corp, Japan Menglu QianTongji University, China Daniel RoyerEcole Supérieure de Physique et de Chimie, France Hervé TrétoutDassault Aviation, France Hubert VoillaumeEADS, France Oliver B WrightHokkaido University, Japan Shu-yi ZhangNanjing University, China Organizing committee Bertrand AudoinChair Sandrine GuitLocal administrator Christophe Aristégui Thomas Dehoux Evelyne Dewayse Yannick Guillet Armelle Guilloux

  10. Psychometric properties of the Physical Activity Scale for the Elderly in Chinese patients with COPD

    Directory of Open Access Journals (Sweden)

    Tao YX

    2016-12-01

    Full Text Available Yan-xia Tao,1,* Lan Wang,1,* Xiao-yan Dong,1 Hong Zheng,2 Ya-shu Zheng,2 Xing-yue Tang,1 Yue Zhao,1 Qing Zhang1 1School of Nursing, Tianjin Medical University, 2Department of Respiratory Care, Tianjin First Center Hospital, Tianjin, People’s Republic of China *These authors contributed equally to this work Background: For patients with COPD, physical activity (PA is recommended as the core component of pulmonary rehabilitation, but there is lack of a validated questionnaire for assessing the PA effectively. Aim: To evaluate the reliability and validity of the Chinese version of Physical Activity Scale for the Elderly (PASE-C in patients with COPD. Methods: A cross-sectional study was conducted with 167 outpatients aged 60 years or older with COPD. Test-retest reliability and internal consistency were calculated by intraclass correlation coefficient (ICC and Cronbach’s coefficient α, respectively. Validity was evaluated by correlation with the International Physical Activity Questionnaire-Short (IPAQ-S, data of pedometer, Self-Efficacy for Managing Chronic Disease 6-Item Scale (SES6, Hospital Anxiety and Depression Scale (HADS, Medical Outcomes Study 36-Item Short Form Health Survey (SF-36, grip strength, and disease characteristics. Results: The PASE-C had an excellent seven-day test-retest reliability (ICC=0.98 and an acceptable internal consistency (Cronbach’s α=0.71. The content validity was supported by an item-content validity index, a scale-content validity index/universal agreement, and a scale-content validity index/average value of 0.70-1, 0.70, and 0.93, respectively. Concurrent validity was tested by correlation with IPAQ-S (r=0.651. Criterion validity was confirmed by correlation with the walking steps (r=0.611 and energy expenditure (r=0.493. For construct validity, PASE-C had correlations with SES6 (r=0.396, HADS for depression (r=-0.234, seven subscales of SF-36 (r=0.182-0.525, grip strength (r=0.341, and disease

  11. Safety of high-dose daptomycin in patients with severe renal impairment

    Directory of Open Access Journals (Sweden)

    Tai CH

    2018-03-01

    Full Text Available Chih-Hsun Tai,1 Chi-Hao Shao,2 Chen-You Chen,2 Shu-Wen Lin,1–3 Chien-Chih Wu1,2 1Department of Pharmacy, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; 2School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan; 3Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan Background: Treatment options are limited for infections due to multidrug-resistant Gram-positive pathogens. Daptomycin is a lipopeptide antibiotic with concentration-dependent killing characteristic and dose-dependent post-antibiotic effect. To achieve optimized pharmacodynamic effect, some experts advocated using a high dose of daptomycin (≥9 mg/kg for severe infections. However, the safety of high-dose therapy in patients with renal impairment remains unknown. This study was aimed to evaluate the safety of daptomycin in patients with severe renal impairment. Methods: This was a retrospective study performed by reviewing electronic medical records. Patients with severe renal impairment who were treated with daptomycin in a tertiary teaching hospital between January 1, 2013, and June 30, 2016, were included for evaluation. The incidence rates of creatine kinase (CK elevation between high-dose (≥9 mg/kg and standard-dose (<9 mg/kg groups were compared. Results: Overall, 164 patients met the inclusion criteria, and 114 (69.5% of them were on renal replacement therapy. Vancomycin-resistant enterococci were the most common pathogens (61.3% of the patients with documented pathogens. The treatment success rate was 51.6% in the 91 patients with bacteremia. The average dose of daptomycin was 8.0±2.3 mg/kg, and 37 (22.6% patients received ≥9 mg/kg. CK levels were followed in 108 (65.9% patients. Significantly higher incidence of CK elevation was found in the high-dose group compared with that in the standard-dose group (10.8% vs 1.6%, P<0.05. Moreover

  12. In vivo tumor targeting and imaging with anti-vascular endothelial growth factor antibody-conjugated dextran-coated iron oxide nanoparticles

    Directory of Open Access Journals (Sweden)

    Hsieh WJ

    2012-06-01

    Full Text Available Wan-Ju Hsieh,1 Chan-Jung Liang,1 Jen-Jie Chieh,4 Shu-Huei Wang,1 I-Rue Lai,1 Jyh-Horng Chen,2 Fu-Hsiung Chang,3 Wei-Kung Tseng,4–6 Shieh-Yueh Yang,4 Chau-Chung Wu,7 Yuh-Lien Chen11Institute of Anatomy and Cell Biology, College of Medicine, 2Department of Electrical Engineering, 3Institute of Biochemistry and Molecular Biology, National Taiwan University, Taipei, Taiwan; 4Institute of Electro-Optical Science and Technology, National Taiwan Normal University, Taipei, Taiwan; 5Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Taipei, Taiwan; 6Department of Medical Imaging and Radiological Sciences, I-Shou University, Taipei, Taiwan; 7Department of Internal Medicine and Primary Care Medicine, National Taiwan University Hospital, Taipei, TaiwanBackground: Active targeting by specific antibodies combined with nanoparticles is a promising technology for cancer imaging and detection by magnetic resonance imaging (MRI. The aim of the present study is to investigate whether the systemic delivery of antivascular endothelial growth factor antibodies conjugating to the surface of functionalized supermagnetic iron oxide nanoparticles (anti-VEGF-NPs led to target-specific accumulation in the tumor.Methods: The VEGF expression in human colon cancer and in Balb/c mice bearing colon cancers was examined by immunohistochemistry. The distribution of these anti-VEGF-NPs particles or NPs particles were evaluated by MRI at days 1, 2, or 9 after the injection into the jugular vein of Balb/c mice bearing colon cancers. Tumor and normal tissues (liver, spleen, lung, and kidney were collected and were examined by Prussian blue staining to determine the presence and distribution of NPs in the tissue sections.Results: VEGF is highly expressed in human and mouse colon cancer tissues. MRI showed significant changes in the T*2 signal and T2 relaxation in the anti-VEGF-NP- injected-mice, but not in mice injected with NP alone. Examination of paraffin

  13. Vesico-ureteral reflux: diagnosis and staging with voiding color doppler US Preliminary experience

    International Nuclear Information System (INIS)

    Farina, Renato; Arena, Carmela; Pennisi, Francesco; Di Benedetto, Vincenzo; Politi, Guido; Di Benedetto, Aurelio

    2000-01-01

    Introduction: The aim of this study is to assess the accuracy of a new US examination: 'voiding color Doppler US ' in the early diagnosis and staging of vesico-ureteral reflux (VUR). The contrast agent US was SH U 508A (Levovist, Schering, Berlin), which produces a chromatic accentuation of the signals picked up by the color Doppler US. Eighteen patients (10 females, eight males) were recruited for the study. In two patients a second examination was performed for follow-up after a VUR conservative therapy. All patients were taken under examination for the evaluation of possible VUR. In all patients the voiding color Doppler US was followed by voiding cystourethrography (VCUG) and the data obtained were compared. Materials and methods: A total of 18 patients aged between 3 months and 10 years, were recruited for the study. The results of the examination were the following: urinary tract infections, follow-up of VUR after conservative or surgical therapy, miscellaneous indications. Voiding color Doppler US was performed, followed by a VCUG. The voiding color Doppler US consists in the trans-catheter introduction of a contrast agent SHU 508 A (Levovist, Schering, Ag. Berlin) into the bladder and a subsequent test with the color Doppler US to show or exclude the presence of reflux into the ureters and/or into the pyelo-caliceal cavity of the kidneys. After the introduction of the contrast agent US the ultrasound scanning of the bladder, the ureters and the pyelo-caliceal cavity was performed to examine the reflux degree. The ultrasonographic investigations were perfomed with AU 590 asyncronus US (Esaote Biomedica, Genova) with a 3.5 MHz convex probe. Results: After the trans-catheter introduction of the contrast agent US, vesico-ureteral reflux occured in 13 patients (77.2%). The reflux degree was also measured by means of ultrasound and was later confirmed by VCUG. The mean times of each examination were as follows: initial US, 10 min; catheterization, 8 min; voiding

  14. Intelligence quotient discrepancy indicates levels of motor competence in preschool children at risk for developmental delays

    Directory of Open Access Journals (Sweden)

    Yu TY

    2016-02-01

    Full Text Available Tzu-Ying Yu,1 Kuan-Lin Chen,2,3 Willy Chou,4,5 Shu-Han Yang,4 Sheng-Chun Kung,4 Ya-Chen Lee,2 Li-Chen Tung4,6,7 1Department of Occupational Therapy, College of Medicine, I-Shou University, Kaohsiung, 2Department of Occupational Therapy, College of Medicine, National Cheng Kung University, Tainan, 3Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 4Department of Physical Medicine and Rehabilitation, Chi-Mei Medical Center, Tainan, 5Department of Recreation and Health Care Management, Cha Nan University of Pharmacy and Science, Tainan, 6School of Medicine, Kaohsiung Medical University, Kaohsiung, 7School of Medicine, Chung Shan Medical University, Taichung, Taiwan Purpose: This study aimed to establish 1 whether a group difference exists in the motor competence of preschool children at risk for developmental delays with intelligence quotient discrepancy (IQD; refers to difference between verbal intelligence quotient [VIQ] and performance intelligence quotient [PIQ] and 2 whether an association exists between IQD and motor competence.Methods: Children’s motor competence and IQD were determined with the motor subtests of the Comprehensive Developmental Inventory for Infants and Toddlers and Wechsler Preschool and Primary Scale of Intelligence™ – Fourth Edition. A total of 291 children were included in three groups: NON-IQD (n=213; IQD within 1 standard deviation [SD], VIQ>PIQ (n=39; VIQ>PIQ greater than 1 SD, and PIQ>VIQ (n=39; PIQ>VIQ greater than 1 SD.Results: The results of one-way analysis of variance indicated significant differences among the subgroups for the “Gross and fine motor” subdomains of the Comprehensive Developmental Inventory for Infants and Toddlers, especially on the subtests of “body-movement coordination” (F=3.87, P<0.05 and “visual-motor coordination” (F=6.90, P<0.05. Motor competence was significantly

  15. Plumbagin elicits differential proteomic responses mainly involving cell cycle, apoptosis, autophagy, and epithelial-to-mesenchymal transition pathways in human prostate cancer PC-3 and DU145 cells

    Directory of Open Access Journals (Sweden)

    Qui JX

    2015-01-01

    Full Text Available Jia-Xuan Qiu,1,2 Zhi-Wei Zhou, 3,4 Zhi-Xu He,4 Ruan Jin Zhao,5 Xueji Zhang,6 Lun Yang,7 Shu-Feng Zhou,3,4 Zong-Fu Mao11School of Public Health, Wuhan University, Wuhan, Hubei, People’s Republic of China; 2Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 3Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA; 4Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, Guizhou, People’s Republic of China; 5Center for Traditional Chinese Medicine, Sarasota, FL, USA; 6Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, People’s Republic of China; 7Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education, Shanghai Jiao Tong University, Shanghai, People’s Republic of ChinaAbstract: Plumbagin (PLB has exhibited a potent anticancer effect in preclinical studies, but the molecular interactome remains elusive. This study aimed to compare the quantitative proteomic responses to PLB treatment in human prostate cancer PC-3 and DU145 cells using the approach of stable-isotope labeling by amino acids in cell culture (SILAC. The data were finally validated using Western blot assay. First, the bioinformatic analysis predicted that PLB could interact with 78 proteins that were involved in cell proliferation and apoptosis, immunity, and signal transduction. Our quantitative proteomic study using SILAC revealed that there were at least 1,225 and 267 proteins interacting with PLB and there were 341 and 107 signaling pathways and cellular functions potentially regulated by PLB in PC-3 and DU145 cells, respectively. These proteins and pathways played a

  16. Estimation of the binding modes with important human cytochrome P450 enzymes, drug interaction potential, pharmacokinetics, and hepatotoxicity of ginger components using molecular docking, computational, and pharmacokinetic modeling studies

    Directory of Open Access Journals (Sweden)

    Qiu JX

    2015-02-01

    Full Text Available Jia-Xuan Qiu,1,2 Zhi-Wei Zhou,3 Zhi-Xu He,4 Xueji Zhang,5 Shu-Feng Zhou,3 Shengrong Zhu11Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 2Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 3Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA; 4Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, Guizhou, People’s Republic of China; 5Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, People’s Republic of ChinaAbstract: Ginger is one of the most commonly used herbal medicines for the treatment of numerous ailments and improvement of body functions. It may be used in combination with prescribed drugs. The coadministration of ginger with therapeutic drugs raises a concern of potential deleterious drug interactions via the modulation of the expression and/or activity of drug-metabolizing enzymes and drug transporters, resulting in unfavorable therapeutic outcomes. This study aimed to determine the molecular interactions between 12 main active ginger components (6-gingerol, 8-gingerol, 10-gingerol, 6-shogaol, 8-shogaol, 10-shogaol, ar-curcumene, ß-bisabolene, ß-sesquiphelandrene, 6-gingerdione, (--zingiberene, and methyl-6-isogingerol and human cytochrome P450 (CYP 1A2, 2C9, 2C19, 2D6, and 3A4 and to predict the absorption, distribution, metabolism, excretion, and toxicity (ADMET of the 12 ginger components using computational approaches and comprehensive literature search. Docking studies showed that ginger components interacted with a panel of amino acids in the active sites of CYP1A

  17. Association of sustained virologic response with reduced progression to liver cirrhosis in elderly patients with chronic hepatitis C

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    Tseng CW

    2016-03-01

    Full Text Available Chih-Wei Tseng,1,2 Ting-Tsung Chang,3,4 Shinn-Jia Tzeng,5 Yu-Hsi Hsieh,1,2 Tsung-Hsing Hung,1,2 Hsiang-Ting Huang,6 Shu-Fen Wu,7 Kuo-Chih Tseng1,2 1Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-Yi, 2School of Medicine, Tzuchi University, Hualien, 3Department of Internal Medicine, National Cheng Kung University Medical College and Hospital, 4Infectious Disease and Signaling Research Center, National Cheng Kung University, Tainan, 5Department of Agronomy, National Chiayi University, 6Department of Nursing, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 7Institute of Molecular Biology, National Chung Cheng University, Chia-Yi, Taiwan Objective: We studied the effect of sustained virologic response (SVR after treatment with pegylated-interferon (PEG-IFN plus ribavirin on the development of liver cirrhosis in elderly patients with chronic hepatitis C (CHC. Patients and methods: This retrospective study enrolled 145 elderly CHC patients (aged ≥65 years who were treatment-naïve and were treated with PEG-IFN plus ribavirin for 6 months between January 2005 and December 2011. Abdominal sonography was performed and liver biochemistry was studied at baseline, at the end of treatment, and every 3–6 months thereafter. The development of liver cirrhosis and related complications was evaluated at the follow-ups. The aspartate aminotransferase-to-platelet ratio index was used as a noninvasive maker for fibrosis. Results: The mean patient age was 69.1±3.3 years, and the average follow-up time was 5.5 years (standard deviation: 2.5 years, range: 1.1–12.3 years. Ninety-five patients (65.5% achieved SVR, and 26 (17.9% discontinued treatment. Twenty-seven patients (18.6% developed liver cirrhosis after treatment. Patients without SVR had significantly greater risk of liver cirrhosis than those with SVR (hazard ratio [HR]: 3.39, 95% confidence interval [CI]: 1.312–8.761, P=0.012. The

  18. Event coverage: ESMO Asia Congress returns to Singapore

    Directory of Open Access Journals (Sweden)

    Editorial Office

    2016-12-01

    , the Myanmar Oncology Society (MOS was represented by Dr. Shu Mon, who is based at the Thurein Mon Clinic in Yangon, Myanmar. During the congress, she gave a presentation on breast cancer management that is specific to the Myanmar experience. According to Dr. Shu Mon, there are only 30 qualified medical oncologists serving the whole of Myanmar, a country with a population of about 51 million people. On establishing collaborations with an academic journal, she said, “MOS is willing to work with a journal such as AMOR to promote the oncology research in Myanmar provided that there are suitable opportunities that both sides could agree on.”During the congress, Assoc. Prof. Dr. Ho Gwo Fuang, the guest managing editor for AMOR’s upcoming special issue and a representative of the Malaysian Oncological Society (MOS at ESMO Asia 2016, was featured as one of the panelists of the ESMO-COS-MOS-NZSO Joint Symposium on ‘New insights into gastrointestinal cancers’. Dr. Ho, who is a medical oncologist at Malaysia’s University Malaya Medical Centre, delivered a talk entitled ‘Adjuvant aspirin for colorectal cancer? A cross-Asia collaborative effort’, a multi-nation initiative involving Singapore, Malaysia, and other Asia Pacific countries. His presentation offered strong scientific and observational data to support the adjuvant use of aspirin in reducing the formation of polyps and metastases after colorectal cancer diagnosis. Towards the end of his presentation, Dr. Ho highlighted the ongoing curation of AMOR’s Special Issue and invited his peers to submit papers to the journal for consideration.

  19. Prescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002

    Science.gov (United States)

    Chen, Fang-Pey; Jong, Maw-Shiou; Chen, Yu-Chun; Kung, Yen-Ying; Chen, Tzeng-Ji; Chen, Fun-Jou; Hwang, Shinn-Jang

    2011-01-01

    Chinese herbal medicine (CHM) has been commonly used for treating insomnia in Asian countries for centuries. The aim of this study was to conduct a large-scale pharmaco-epidemiologic study and evaluate the frequency and patterns of CHM use in treating insomnia. We obtained the traditional Chinese medicine (TCM) outpatient claims from the National Health Insurance in Taiwan for the year 2002. Patients with insomnia were identified from the diagnostic code of International Classification of Disease among claimed visiting files. Corresponding prescription files were analyzed, and an association rule was applied to evaluate the co-prescription of CHM. Results showed that there were 16 134 subjects who visited TCM clinics for insomnia in Taiwan during 2002 and received a total of 29 801 CHM prescriptions. Subjects between 40 and 49 years of age comprised the largest number of those treated (25.3%). In addition, female subjects used CHMs for insomnia more frequently than male subjects (female : male = 1.94 : 1). There was an average of 4.8 items prescribed in the form of either an individual Chinese herb or formula in a single CHM prescription for insomnia. Shou-wu-teng (Polygonum multiflorum) was the most commonly prescribed single Chinese herb, while Suan-zao-ren-tang was the most commonly prescribed Chinese herbal formula. According to the association rule, the most commonly prescribed CHM drug combination was Suan-zao-ren-tang plus Long-dan-xie-gan-tang, while the most commonly prescribed triple drug combination was Suan-zao-ren-tang, Albizia julibrissin, and P. multiflorum. Nevertheless, further clinical trials are needed to evaluate the efficacy and safety of these CHMs for treating insomnia. PMID:19339485

  20. Prescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002

    Directory of Open Access Journals (Sweden)

    Fang-Pey Chen

    2011-01-01

    Full Text Available Chinese herbal medicine (CHM has been commonly used for treating insomnia in Asian countries for centuries. The aim of this study was to conduct a large-scale pharmaco-epidemiologic study and evaluate the frequency and patterns of CHM use in treating insomnia. We obtained the traditional Chinese medicine (TCM outpatient claims from the National Health Insurance in Taiwan for the year 2002. Patients with insomnia were identified from the diagnostic code of International Classification of Disease among claimed visiting files. Corresponding prescription files were analyzed, and an association rule was applied to evaluate the co-prescription of CHM. Results showed that there were 16 134 subjects who visited TCM clinics for insomnia in Taiwan during 2002 and received a total of 29 801 CHM prescriptions. Subjects between 40 and 49 years of age comprised the largest number of those treated (25.3%. In addition, female subjects used CHMs for insomnia more frequently than male subjects (female : male = 1.94 : 1. There was an average of 4.8 items prescribed in the form of either an individual Chinese herb or formula in a single CHM prescription for insomnia. Shou-wu-teng (Polygonum multiflorum was the most commonly prescribed single Chinese herb, while Suan-zao-ren-tang was the most commonly prescribed Chinese herbal formula. According to the association rule, the most commonly prescribed CHM drug combination was Suan-zao-ren-tang plus Long-dan-xie-gan-tang, while the most commonly prescribed triple drug combination was Suan-zao-ren-tang, Albizia julibrissin, and P. multiflorum. Nevertheless, further clinical trials are needed to evaluate the efficacy and safety of these CHMs for treating insomnia.

  1. PREFACE: Preface

    Science.gov (United States)

    Luo, Qingming; Wang, Lihong V.; Tuchin, Valery V.

    2011-02-01

    and imaging from all over the world, including the United States, Russia, Australia, Canada, Israel, France, Ireland, Japan, Korea and China. The major topics covered at the conference and presented in this volume include: Photonic Therapeutics, Diagnostics and Instrumentations; Tissue Optics and Laser Tissue Interaction; Biomedical Spectroscopy and Microscopy; Multimodal and Hybrid Biomedical Imaging; and Optical Molecular Imaging. The conference voted for the three best student papers; awards were presented to the participant students whose posters were recognized as excellent and who took part in the oral presentation competition. The conference received 133 submitted abstracts, and this volume of the Journal of Physics: Conference Series includes a selection of 53 excellent submissions. The Conference Secretariat and Local Organizing Committee deserve recognition for planning a smoothly run and productive conference with comprehensive, instructive lectures and innovative work displayed in poster presentations. The faculties and students from Britton Chance Center for Biomedical Photonics were dedicated to their work in reception and service during the conference. It is a pleasure to thank all of them for their efficient and hard work. We are also grateful for the financial support from 111 Project (B07038), and the assistance in organization and coordination from Wuhan National Laboratory for Optoelectronics and Huazhong University of Science and Technology. Finally, we would like to thank all the authors for their contributions to PIBM 2010 and all the members of the Committees for their cooperation and time spent reviewing submissions. Special thanks are due to the Advisory Committee members Shu Chien, Aaron Ciechanover, Steve Dahms, Da Hsuan Feng, Steven R Goodman, Brian Salzberg, Fujia Yang, Jianquan Yao, Baoyong Zheng and Olivia Ho Cheng for their participation on-site, and their significant contributions to the conference. Wuhan, PR ChinaDecember, 2010

  2. Book Reviews

    Directory of Open Access Journals (Sweden)

    Jan Michiel Otto

    1991-01-01

    ., Deborah Gewertz (eds. - Marijke J. Klokke, Annette Claben, Kann die Gupta-Kunst Kalidasas Werke illustrieren? Teil I: Text; Teil II: Abbildungen. Berlin: Dietrich Reimer, 1988. [Marburger Studien zur Afrika- und Asienkunde, Serie B: Asien, Band 11.] 90, XLV pp., 10 figs, 32 pls. - J. Kommers, Michael Young, Malinowski among the Magi. The Natives of Mailu, London and New York: Routledge, 1988. [International library of Anthropology.] viii + 355 pp. - Niels Mulder, Bernhard Dahm, Culture and technological development in Southeast Asia. Baden-Baden: Nomos Verlagsgesellschaft, 1988., Gotz Link (eds. - Jan Michiel Otto, F. von Benda-Beckmann, Between kinship and the state; Social security and law in developing countries, Dordrecht: Foris, 1988. vii + 495 pp., K. von Benda-Beckmann, E. Casino (eds. - Nigel Phillips, Rainer Carle, Cultures and societies of North Sumatra, Berlin and Hamburg: Dietrich Reimer, 1987. [Veroffentlichungen des Seminars für Indonesische und Sudseesprachen der Universität Hamburg, Band 19.] 514 pp. - R. De Ridder, James J. Fox, To speak in pairs; Essays on the ritual languages of Eastern Indonesia, Cambridge: Cambridge University Press, 1988. [Cambridge studies in oral literature 15.] xi + 338 pp.; bibl.; ills. - Matthew Schoffeleers, Serge Tcherkezoff, Duel classification reconsidered (Translation by Martin Thom, New York/Paris: Cambridge University Press and Éditions de la Maison des Sciences de l’Homme, 1987, 157 pp. - G.J. Schutte, J.L. Blussé, De dagregisters van het kasteel Zeelandia, Taiwan 1629-1662. Deel I: 1629-1641, uitgegeven door J.L. Blussé, M.E. van Opstall en Ts’ao Yung-ho, met medewerking van Chiang Shu-sheng en W. Milde. [Rijks Geschiedkundige Publicatiën, Grote Serie 195.] ‘s-Gravenhage: Martinus Nijhoff, 1986. xxi + 548 pp., map, indices - H. Steinhauer, Olaf H. Smedal, Lom-Indonesian-English and English-Lom Wordlists, NUSA Linguistic studies of Indonesian and other languages in Indonesia, Vol. 28/29, 1987. viii

  3. Timing of Early Aptian demise of northern Tethyan carbonate platforms - chemostratigraphic versus biostratigraphic evidence

    Science.gov (United States)

    Huck, Stefan; Immenhauser, Adrian; Heimhofer, Ulrich; Rameil, Niels

    2010-05-01

    platform related to the unfolding oceanic anoxic event 1a (« Selli event »). Revue de Paléobiologie, 27, 461-468. Gradstein, F.M., Ogg, J.G., Smith, A.G., Bleeker, W. and Lourens, L.J. (2004) A new Geologic Time Scale, with special reference to Precambrian and Neogene. Episodes, 27, 83-100. Huck, S., Rameil, N., Korbar, T., Heimhofer, U., Wieczorek, T.D. and Immenhauser, A. (2010) Latitudinally different responses of Tethyan shoal-water carbonate systems to the Early Aptian oceanic anoxic event (OAE 1a). Sedimentology (pending acceptance of revised version). Moreno-Bedmar, J.A., Company, M., Bover-Arnal, T., Salas, R., Delanoy, G., Martinez, R. and Grauges, A. (2009) Biostratigraphic characterization by means of ammonoids of the lower Aptian Oceanic Anoxic Event (OAE 1a) in the eastern Iberian Chain (Maestrat Basin, eastern Spain). Cretaceous Research, 30, 864-872. Rameil, N., Immenhauser, A., Warrlich, G.M.D., Vahrenkamp, V.C., Hillgärtner, H., Droste, H.J., Al-Mahruqi, I., Buhl, D., Schulte, U. and Kunkel, C. (2009) Chemostratigraphy-based correlation of Lower Shu'aiba Formation platform sections (Early Aptian, Sultanate of Oman). In: Aptian Stratigraphy and Petroleum Habitat of the Eastern Arabian Plate (Eds F.S.P. van Buchem, M.I. Al-Husseini, F. Maurer and H.J. Droste), 4. GeoArabia Special Publication (in press), Gulf PetroLink, Bahrain. Weissert, H., Lini, A., Föllmi, K.B. and Kuhn, O. (1998) Correlation of Early Cretaceous carbon isotope stratigraphy and platform drowning events: a possible link? Palaeogeography, Palaeoclimatology, Palaeoecology, 137, 189-203.

  4. Hsa-microRNA-181a is a regulator of a number of cancer genes and a biomarker for endometrial carcinoma in patients: a bioinformatic and clinical study and the therapeutic implication

    Directory of Open Access Journals (Sweden)

    He S

    2015-02-01

    Full Text Available Shuming He,1 Shumei Zeng,1 Zhi-Wei Zhou,2,3 Zhi-Xu He,3 Shu-Feng Zhou2,3 1Department of Obstetrics and Gynecology, Xiaolan People’s Hospital affiliated to Southern Medical University, Zhongshan, Guangdong, People’s Republic of China; 2Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, Guizhou, People’s Republic of China Abstract: The aberrant expression of human microRNA-181a-1 (hsa-miR-181a has been implicated in the pathogenesis of various cancers, serving as an oncogene or a tumor suppressor. However, the role of hsa-miR-181a in the pathogenesis of endometrial carcinoma (EC and its clinical significance are unclear. This study aimed to search for the molecular targets of hsa-miR-181a using bioinformatic tools and then determine the expression levels of hsa-miR-181a in normal, hyperplasia, and EC samples from humans. To predict the targets of hsa-miR-181a, ten different algorithms were used, including miRanda-mirSVR, DIANA microT v5.0, miRDB, RNA22 v2, TargetMiner, TargetScan 6.2, PicTar, MicroCosm Targets v5, and miRWALK. Two algorithms, TarBase 6.0 and miRTarBase, were used to identify the validated targets of hsa-miR-181a-5p (a mature product of hsa-miR-181a, and the web-based Database for Annotation, Visualization and Integrated ­Discovery (DAVID 6.7 was used to provide biological functional interpretation of the validated targets of hsa-miR-181a-5p. A total of 78 formalin-fixed, paraffin-embedded tissue specimens from 65 patients and 13 healthy subjects were collected and examined, including normal endometrium (n=13, endometrial hyperplasia (n=18, and EC (37 type I and 10 type II EC cases. Our bioinformatic studies have showed that hsa-miR-181a might regulate a large number of

  5. Gas Clouds in Whirlpool Galaxy Yield Important Clues Supporting Theory on Spiral Arms

    Science.gov (United States)

    2004-06-01

    clouds. Their results provide strong support for a theory that "density waves" explain how spiral arms can persist in a galaxy without winding themselves so tightly that, in effect, they disappear. The density-wave theory, proposed by Frank Shu and C.C. Lin in 1964, says that a galaxy's spiral pattern is a wave of higher density, or compression, that revolves around the galaxy at a speed different from that of the galaxy's gas and stars. Schinnerer and her colleagues studied a region in one of M51's spiral arms that presumably has just overtaken and passed through the density wave. Their data indicate that gas on the trailing edge of the spiral arm, which has most recently passed through the density wave, is both warmer and more turbulent than gas in the forward edge of the arm, which would have passed through the density wave longer ago. "This is what we would expect from the density-wave theory," Schinnerer said. "The gas that passed through the density wave earlier has had time to cool and lose the turbulence caused by the passage," she added. "Our results show, for the first time, how the density wave operates on a cloud-cloud scale, and how it promotes and prevents star formation in spiral arms," Aalto said. The next step, the scientists say, is to look at other spiral galaxies to see if a similar pattern is present. That will have to wait, Schinnerer said, because the radio emission from CO molecules that provides the information on temperature and turbulence is very faint. "When the Atacama Large Millimeter Array (ALMA) comes on line, it will have the ability to extend this type of study to other galaxies. We look forward to using ALMA to test the density-wave model more thoroughly," Schinnerer said. ALMA is a millimeter-wave observatory that will use 64, 12-meter-diameter dish antennas on the Atacama Desert of northern Chile. Now under construction, ALMA will provide astronomers with an unprecedented capability to study the Universe at millimeter wavelengths. The

  6. A higher-order conservation element solution element method for solving hyperbolic differential equations on unstructured meshes

    Science.gov (United States)

    Bilyeu, David

    code development, a one-dimensional solver for the Euler equations was developed. This work is an extension of Chang's work on the fourth-order CESE method for solving a one-dimensional scalar convection equation. A generic formulation for the nth-order CESE method, where n ≥ 4, was derived. Indeed, numerical implementation of the scheme confirmed that the order of convergence was consistent with the order of the scheme. For the two- and three-dimensional solvers, SOLVCON was used as the basic framework for code implementation. A new solver kernel for the fourth-order CESE method has been developed and integrated into the framework provided by SOLVCON. The main part of SOLVCON, which deals with unstructured meshes and parallel computing, remains intact. The SOLVCON code for data transmission between computer nodes for High Performance Computing (HPC). To validate and verify the newly developed high-order CESE algorithms, several one-, two- and three-dimensional simulations where conducted. For the arbitrary order, one-dimensional, CESE solver, three sets of governing equations were selected for simulation: (i) the linear convection equation, (ii) the linear acoustic equations, (iii) the nonlinear Euler equations. All three systems of equations were used to verify the order of convergence through mesh refinement. In addition the Euler equations were used to solve the Shu-Osher and Blastwave problems. These two simulations demonstrated that the new high-order CESE methods can accurately resolve discontinuities in the flow field.For the two-dimensional, fourth-order CESE solver, the Euler equation was employed in four different test cases. The first case was used to verify the order of convergence through mesh refinement. The next three cases demonstrated the ability of the new solver to accurately resolve discontinuities in the flows. This was demonstrated through: (i) the interaction between acoustic waves and an entropy pulse, (ii) supersonic flow over a circular

  7. Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and NCI-N78 cells

    Directory of Open Access Journals (Sweden)

    Yuan CX

    2015-03-01

    Full Text Available Chun-Xiu Yuan,1,2 Zhi-Wei Zhou,2,3 Yin-Xue Yang,4 Zhi-Xu He,3 Xueji Zhang,5 Dong Wang,6 Tianxing Yang,7 Si-Yuan Pan,8 Xiao-Wu Chen,9 Shu-Feng Zhou2 1Department of Oncology, General Hospital, Ningxia Medical University, Yinchuan, People’s Republic of China; 2Department of Pharmaceutical Science, College of Pharmacy, University of South Florida, Tampa, FL, USA; 3Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guiyang Medical University, Guiyang, 4Department of Colorectal Surgery, General Hospital, Ningxia Medical University, Yinchuan, 5Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, 6Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, People’s Republic of China; 7Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT, USA; 8Department of Pharmacology, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 9Department of General Surgery, The First People’s Hospital of Shunde, Southern Medical University, Shunde, People’s Republic of China Abstract: Gastric cancer is the second leading cause of cancer-related death worldwide, with a poor response to current chemotherapy. Danusertib is a pan-inhibitor of the Aurora kinases and a third-generation Bcr-Abl tyrosine kinase inhibitor with potent anticancer effects, but its antitumor effect and underlying mechanisms in the treatment of human gastric cancer are unknown. This study aimed to investigate the effects of danusertib on cell growth, apoptosis, autophagy, and epithelial to mesenchymal transition and the molecular mechanisms involved in human gastric cancer AGS and NCI-N78 cells. The results showed that danusertib had potent growth-inhibitory, apoptosis-inducing, and

  8. Application of Barcoding to Reduce Error of Patient Identification and to Increase Patient's Information Confidentiality of Test Tube Labelling in a Psychiatric Teaching Hospital.

    Science.gov (United States)

    Liu, Hsiu-Chu; Li, Hsing; Chang, Hsin-Fei; Lu, Mei-Rou; Chen, Feng-Chuan

    2015-01-01

    Learning from the experience of another medical center in Taiwan, Kaohsiung Municipal Kai-Suan Psychiatric Hospital has changed the nursing informatics system step by step in the past year and a half . We considered ethics in the original idea of implementing barcodes on the test tube labels to process the identification of the psychiatric patients. The main aims of this project are to maintain the confidential information and to transport the sample effectively. The primary nurses had been using different work sheets for this project to ensure the acceptance of the new barcode system. In the past two years the errors in the blood testing process were as high as 11,000 in 14,000 events per year, resulting in wastage of resources. The actions taken by the nurses and the new barcode system implementation can improve the clinical nursing care quality, safety of the patients, and efficiency, while decreasing the cost due to the human error.

  9. On textual and contextual position of the ophthalmological treatise of bodhisattva nāgārjuna.

    Science.gov (United States)

    Kim, Seongsu; Kang, Sungyong

    2013-04-01

    Medical knowledge in India began to be introduced to China in earliest from the Later Han Dynasty period to the times of Wei-Qin and South & North Dynasties. This is proved by many Buddhist medical books appeared in those days. Of the contents of Indian medicine, the theory of four major elements affected Chinese medicine more than did the theory of body fluids. Based on the theory of four major elements that was began to be introduced in Fú shuō fú yī jīng, an attempt to establish a new medical system was made in Zhŏu hòu băi yīfāng written by Táo Hóng-jĭng and Sūn Sī-miăo who tried to develop etiology further but could not achieve any great outcomes. Unlike the foregoing situation, Indian medicine aroused a large echo in China in the field of ophthalmology with ophthalmological knowledge mentioned in Suśrutasa hitā and 'Jīnzhēn-shù'(cataract couching) introduced as a surgical treatment of cataract. The Suśrutasa hitā which is one of the three major texts of Indian medicine contains additional information on surgical operations not introduced in the Carakasa hitā. The technique of cataract surgery was particularly popular in the Tang and Song dynasty periods in China under the name Lóng shù pú sà yăn lùn(The Ophthalmological Treatise of Bodhisattva Nāgārjuna) or Lóng shù lùn and was even designated as a subject to educate medical officers. While the original text of Lóng shù pú sà yăn lùn was not handed down, the first testimony that show the trace of the introduction of this text into China was the Tiān zhú jīng lùn yăn mentioned in Wài tái mì yào(Arcane Essential from the Imperial Library) written by Wang Tao. Long shàng dào ren who was mentioned as the compiler of the book is assumed to be Lóng shù. Although Tiān zhú jīng lùn yăn introduced anatomical knowledge about the eyeball that could have not been in the traditional Chinese medicine, this book has only limited quantity of information in this

  10. Call for Papers and Announcement Joint International Conference of Industrial Engineering and Engineering Management (IE&EM'2002)And International Conference on Electronic Commerce Engineering (ICECE'2002)%“2002年工业工程与工程管理国际会议(IE&EM’2002)”暨“2002年电子商务工程国际会议(IceCE’2002)”征文通知

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Metropolitan University, UK Members: (in alphabetic order) Fukuda Shuichi (Japan) Ning Ruxin (China) Qi Ershi (China) Mitchell M. Tseng (HK) G. Doumeingts (France) Richard Harrison (UK) Jim Browne (Ireland) F.-L Krause (Germany) Lei Yuanzhong (NSFC, China) Li Ming (NSFC, China) Li Peigeng (China) Liu Fei (China) Lin Zhongqin(863/automation, China) Roddy MacLeod (UK) Chris McMahon (UK) Martin Moltrecht(Germany) Sun Jiaguang (863/automation, China) Tang Xiaoqing (China) Wang Ruigang (CMES, China) Wang Yingluo(China) Wen Yuping (Tsinghua, Taiwan) Xia Guoping (China) Yan Junqi (China) Organizing Committee Chairman: Zheng Li, Tsinghua University (China) Co-Chairmen: Kai Cheng (UK) Jiang Pingyu (China) Guoquan Huang (Hong Kong) Li Congdong (China) Members: (in alphabetic order) Richard Bateman (UK) Liu Dacheng (China) Pan P.Y. (UK) Jeremy Toussaint (UK) Wu Shu(China) Yu Ming (China)Secretariat: General Secretary: Yu Ming (China) Members: Cai Linning (China) Jiang Zhibin (China) Yi Shuping (China) Zeng Haiming(China) Zhang Wei (China) Zhao Huanmai (China) Submissions Submitted papers should be in English and will be accepted in two types: regular papers limited to 8 pages, after that S|100 per additional page, but no more than 12 pages, and short papers limited to 4 pages. Papers submitted should be in MS Word or its compressed (zip) form. The format of submitted papers is: A4, 20mm margin at left side and 28mm at right side; double column, each 81mm wide with a 8mm space between columns; 18pt Times New Roman for the title; 10.5pt Times New Roman for text, author(s), affiliation(s), mailing address(es) and e-mail address(es); the space between lines is single space and the space between words is standard. On the first page, the top 50mm of both columns should be reserved for the title, author(s), affiliation(s), mailing address(es) and email address(es), which should be centered across both columns; on the second and subsequent pages, the text or illustrations should begin at the top

  11. Removal of Reactive Dyes (Green, Orange, and Yellow from Aqueous Solutions by Peanut Shell Powder as a Natural Adsorbent

    Directory of Open Access Journals (Sweden)

    Hosein Nadi

    2012-11-01

    -bireactive dye removal. Appl Catal B Environ 2006;67(1:86-92. 2. Shu HY, Huang CR. Degradation of commercial ago dyes in water using ozonation and UV enhanced ozonation process. Chemosphere 1995;31(8:3813-25. 3. Clarke EA, Anliker R. Organic dyes and pigments. In The Handbook of Environmental Chemistry. Berlin: Springer-Verlag; 1980;3(part A:181-215. 4. Riu J, Schönsee I, Barceló D. Determination of sulfonated azo dyes in water and wastewater. TrAC Trends Anal Chem1997;16(7:405-19. 5. Venkatamohan S, Mamatha VVS, Karthikeyan J. Removal of colour from acid and direct dyes by adsorption onto silica fumes. Fresenius Envion Bull 1998;7(1:51-8. 6. da Silveira Neta JJ, Moreira GC, da Silva CJ, Reis C, Reis EL. Use of polyurethane foams for the removal of the Direct Red 80 and Reactive Blue 21 dyes in aqueous medium. Desalination 2011;281:55–60. 7. Paul J, Naik DB, Sabharwal S. High energy induced decoloration and mineralization of reactive red 120 dye in aqueous solution:a steady state and pulse radiolysis study. Radiat Phys Chem. 2010;79(7:770-6. 8. Merzouk B, Gourich B, Madani K, Vial Ch, Sekki A. Removal of a disperse red dye from synthetic wastewater by chemical coagulation and continuous electrocoagulation. A comparative study. Desalination 2011;272(1-3:246-53. 9. Gholami Borujeni F, Mahvi AH, Naseri S, Faramarzi MA, Nabizadeh R, Alimohammadi M. Application of immobilized horseradish peroxidase for removal and detoxification of azo dye from aqueous solution. Res J Chem Environ 2011;15:217-22. 10. Gholami-Borujeni F, Mahvi AH, Nasseri S, Faramarzi MA, Nabizadeh R, Alimohammadi M. Enzymatic treatment and detoxification of acid orange 7 from textile wastewater. Appl Biochem Biotechnol 2011;165(5-6:1274-84. 11. Dehghani MH, Mesdaghinia AR, Nasseri S, Mahvi AH, Azam K. Application of SCR technology for degradation of reactive yellow dye in aqueous solution. Water Qual Res J Can 2008;43(2/3:183-7. 12. Mahvi AH, Ghanbarian M, Nasseri S, Khairi A. Mineralization and discoloration of

  12. PREFACE: Preface

    Science.gov (United States)

    Ye, Chaohui; Wang, Zhong Lin; Zhou, Bingkun

    2011-02-01

    National Laboratory for Optoelectronics (China)Junqiang Sun, Wuhan National Laboratory for Optoelectronics (China) 4. OPTOELECTRONIC SENSING AND IMAGING (OSI)Editors:Kecheng Yang, Wuhan National Laboratory for Optoelectronics (China)Pengcheng Li, Wuhan National Laboratory for Optoelectronics (China) 5. SOLAR CELLS, SOLID-STATE LIGHTING AND INFORMATION DISPLAY TECHNOLOGIES (SSID)Editors:Hiroshi Amano, Meijo University (Japan)Yibing Cheng, Monash University (Australia)Jinzhong Yu, Institute of Semiconductor, CAS (China)Changqing Chen, Wuhan National Laboratory for Optoelectronics (China)Hongwei Han, Wuhan National Laboratory for Optoelectronics (China)Guoli Tu, Wuhan National Laboratory for Optoelectronics (China) 6. TERA-HERTZ SCIENCE AND TECHNOLOGY (THST)Editors:Jianquan Yao, Tianjin University (China)Shenggang Liu, University of Electronic Science and Technology of China (China)X C Zhang, Rensselaer Polytechnic Institute (USA)Jinsong Liu, Wuhan National Laboratory for Optoelectronics (China) International Advisory Committee:Yibing Cheng, Monash University (Australia)Stephen Z D Cheng, University of Akron (USA)Min Gu, Swinburne University of Technology (Australia)Andrew B Holmes, the University of Melbourne (Australia)Chinlon Lin, Bell Laboratory (retired, USA)Xun Li, McMaster University (Canada)Shenggang Liu, University of Electronic Science and Technology of China (China)Jesper Moerk, Technical University of Denmark (Denmark)Dennis L Matthews, University of California, Davis (USA)Jiacong Shen, Jilin University (China)Ping Shum, Nanyang Technological University (Singapore)Chester C T Shu, Chinese University of Hong Kong (China)Valery V Tuchin, Saratov State University (Russia)Bruce Tromberg, University of California/Irvine (USA)Peiheng Wu, University of Nanjing (China)Alan Willner, University of Southern California (USA)Lihong Wang, Washington University in St. Louis (USA)C P Wong, Georgia Institute of Technology (USA)Jianquan Yao, Tianjin University (China)Xi Zhang

  13. DIET, BODY MASS INDEX AND DENTAL CARIES AMONG THAI CHILDREN AGED 3 TO 5 YEARS.

    Science.gov (United States)

    Mitrakul, Kemthong; Arunakul, Malee; Asvanund, Yuwadee; Laisirireoungrai, Tanai; Praneechotiros, Tharawut; Tevavichulada, Peerapol

    2017-03-01

    Early childhood caries (ECC) can cause pain and interfere with healthy nutrition affecting a child growth. The aim of this study was to determine if there is an association between dental caries and body mass index (BMI) among Thai children aged 3 to 5 years. We randomly selected 100 students attending Suan Missakawan School, Bangkok, Thailand. We examined each child to determine the number of decayed, missing and filled teeth (DMFT) giving a DMFT score. We also measured the height and weight for each subject and calculated their body mass index (BMI) as weight in kilograms divided by height in meter squared. Parents or guardians were asked to complete a questionnaire asking general information and the diet of the child. Data from the questionnaire were analyzed using the Kruskal-Wallis test. Associations between caries and variables were examined using the Spearman’s correlation with significance set at pcaries (DMFT score=0), 32% had a few caries (DMFT score=0.1-3.0), 14% had many caries (DMFT scores=3.1-6.9), and 36% had very many caries (DMFT≥7). The DMFT score was not significantly associated with a history of sugar consumption or BMI. The DMFT score was significantly negatively associated with estimated fat consumption and estimated iron consumption based on the diet reported by the parents or guardians. Further studies are needed to determine if these reported diets reflect actual consumption and if the associations are still significant.

  14. Observational Studies on Evaluating the Safety and Adverse Effects of Traditional Chinese Medicine

    Science.gov (United States)

    Tang, Jin-Ling; Wang, Jung-Der

    2013-01-01

    Background. This study aims to share our experiences when carrying out observational studies of traditional Chinese medicine (TCM). Methods. We have proactively monitored the safety profiles of Duhuo Jisheng Tang (DJT), Suan Zao Ren Tang (SZRT), and TMN-1. A list of adverse events (AEs), complete blood counts, and liver and kidney function tests were obtained from the participants during their scheduled hospital visits. Retrospective observational studies were conducted based on the reimbursement database of the National Health Insurance system, Taiwan, to explore the relationship between the use of TCM that have been adulterated by aristolochic acid and the risk from both nephrotoxins and carcinogens. Results. A total of 221, 287, and 203 AEs were detected after SZRT, DJT, and TMN-1 had been taken, respectively. Dizziness, headache, stomach ache, and diarrhea were judged to be probably related to SZRT treatment. Retrospective observational studies found an association between the consumption of aristolochic acid-containing Chinese formulae such as Mu Tong and an increased risk of CKD, ESRD, and urinary tract cancer. Conclusion. Prospective and retrospective observational studies seem to have specific advantages when investigating the safety and adverse effects of TCM therapies, as well as possibly other alternative/complementary therapies. PMID:24159351

  15. Screening to Identify Commonly Used Chinese Herbs That Affect ERBB2 and ESR1 Gene Expression Using the Human Breast Cancer MCF-7 Cell Line

    Directory of Open Access Journals (Sweden)

    Jen-Hwey Chiu

    2014-01-01

    Full Text Available Aim. Our aim the was to screen the commonly used Chinese herbs in order to detect changes in ERBB2 and ESR1 gene expression using MCF-7 cells. Methods. Using the MCF-7 human breast cancer cell line, cell cytotoxicity and proliferation were evaluated by MTT and trypan blue exclusion assays, respectively. A luciferase reporter assay was established by transient transfecting MCF-7 cells with plasmids containing either the ERBB2 or the ESR1 promoter region linked to the luciferase gene. Chinese herbal extracts were used to treat the cells at 24 h after transfection, followed by measurement of their luciferase activity. The screening results were verified by Western blotting to measure HER2 and ERα protein expression. Results. At concentrations that induced little cytotoxicity, thirteen single herbal extracts and five compound recipes were found to increase either ERBB2 or ESR1 luciferase activity. By Western blotting, Si-Wu-Tang, Kuan-Shin-Yin, and Suan-Tsao-Ren-Tang were found to increase either HER2 or ERα protein expression. In addition, Ligusticum chuanxiong was shown to have a great effect on ERBB2 gene expression and synergistically with estrogen to stimulate MCF-7 cell growth. Conclusion. Our results provide important information that should affect clinical treatment strategies among breast cancer patients who are receiving hormonal or targeted therapies.

  16. Observational Studies on Evaluating the Safety and Adverse Effects of Traditional Chinese Medicine

    Directory of Open Access Journals (Sweden)

    Jung-Nein Lai

    2013-01-01

    Full Text Available Background. This study aims to share our experiences when carrying out observational studies of traditional Chinese medicine (TCM. Methods. We have proactively monitored the safety profiles of Duhuo Jisheng Tang (DJT, Suan Zao Ren Tang (SZRT, and TMN-1. A list of adverse events (AEs, complete blood counts, and liver and kidney function tests were obtained from the participants during their scheduled hospital visits. Retrospective observational studies were conducted based on the reimbursement database of the National Health Insurance system, Taiwan, to explore the relationship between the use of TCM that have been adulterated by aristolochic acid and the risk from both nephrotoxins and carcinogens. Results. A total of 221, 287, and 203 AEs were detected after SZRT, DJT, and TMN-1 had been taken, respectively. Dizziness, headache, stomach ache, and diarrhea were judged to be probably related to SZRT treatment. Retrospective observational studies found an association between the consumption of aristolochic acid-containing Chinese formulae such as Mu Tong and an increased risk of CKD, ESRD, and urinary tract cancer. Conclusion. Prospective and retrospective observational studies seem to have specific advantages when investigating the safety and adverse effects of TCM therapies, as well as possibly other alternative/complementary therapies.

  17. EDITORIAL: Focus on Dilute Magnetic Semiconductors FOCUS ON DILUTE MAGNETIC SEMICONDUCTORS

    Science.gov (United States)

    Chambers, Scott A.; Gallagher, Bryan

    2008-05-01

    Chisholm, J D Budai and D P Norton Role of charge carriers for ferromagnetism in cobalt-doped rutile TiO2 T Fukumura, H Toyosaki, K Ueno, M Nakano and M Kawasaki Ab-initio study of exchange constants and electronic structure in diluted magnetic group-IV semiconductors Silvia Picozzi and Marjana Ležaić Phase coherent transport in (Ga,Mn)As D Neumaier, K Wagner, U Wurstbauer, M Reinwald, W Wegscheider and D Weiss Hydrogen interstitials-mediated ferromagnetism in MnxGe1-x magnetic semiconductors Xin-Xin Yao, Shi-Shen Yan, Shu-Jun Hu, Xue-Ling Lin, Chong Han, Yan-Xue Chen, Guo-Lei Liu and Liang-Mo Mei Electronic structures of magnetic semiconductors FeCr2Se4 and Fe0.5Cu0.5Cr2Se4 B I Min, Seung Su Baik, H C Choi, S K Kwon and J-S Kang Investigation of pure and Co2+-doped ZnO quantum dot electronic structures using the density functional theory: choosing the right functional Ekaterina Badaeva, Yong Feng, Daniel R Gamelin and Xiaosong Li Magnetic properties of sol-gel-derived doped ZnO as a potential ferromagnetic semiconductor: a synchrotron-based study N R S Farley, K W Edmonds, A A Freeman, G van der Laan, C R Staddon, D H Gregory and B L Gallagher Local electronic structure of Cr in the II-VI diluted ferromagnetic semiconductor Zn1-xCrxTe M Kobayashi, Y Ishida, J I Hwang, G S Song, A Fujimori, C S Yang, L Lee, H-J Lin, D J Huang, C T Chen, Y Takeda, K Terai, S-I Fujimori, T Okane, Y Saitoh, H Yamagami, K Kobayashi, A Tanaka, H Saito and K Ando Lack of ferromagnetism in n-type cobalt-doped ZnO epitaxial thin films T C Kaspar, T Droubay, S M Heald, P Nachimuthu, C M Wang, V Shutthanandan, C A Johnson, D R Gamelin and S A Chambers XMCD studies on Co and Li doped ZnO magnetic semiconductors Thomas Tietze, Milan Gacic, Gisela Schütz, Gerhard Jakob, Sebastian Brück and Eberhard Goering Ferromagnetic semiconductors and the role of disorder B W Wessels An extensive comparison of anisotropies in MBE grown (Ga,Mn)As material C Gould, S Mark, K Pappert, R G Dengel, J Wenisch, R P

  18. Nesting biology of an Oriental carpenter bee, Xylocopa (Biluna nasalis Westwood, 1838, in Thailand (Hymenoptera, Apidae, Xylocopinae

    Directory of Open Access Journals (Sweden)

    Watcharapong Hongjamrassilp

    2014-12-01

    Full Text Available The biological study of wild non-Apis bees can provide useful information that may help with the pollination of food crops and native plants in areas where the keeping of honey bee colonies is restricted or affected by CCD. Here, we describe the nesting biology of the Oriental large carpenter bee, Xylocopa (Biluna nasalis Westwood, 1838. An aggregation of more than 80+ bamboo nests of X. nasalis was discovered in Suan Pheung district, Ratch Buri province, Thailand on the 25th of May 2012. We collected 27 nests from the site to dissect, measure the external and internal nest architecture, and analyze the pollen composition of the pollen masses. X. nasalis constructs linear unbranched nests with nest entrance mostly located at the open-end of the bamboo culms. The nest length and the branch diameter of the nest entrance (excluding nesting edge are 25.40 ± 6.95 cm and 17.94 ± 6.00 mm, and the maximum number of provisioned cells is 8. A biased sex ratio of 8♀: 1♂ is reported, with up to 7 adults inhabiting in a single nest. 29 pollen types were identified from 14 pollen masses using an acetolysis method and visualization under both light microscope and scanning electron microscope. 13 pollen types were considered as major pollen sources (contribute ≥ 1% in total pollen volume; however, only 10 can be identified to family and generic levels. The dominant pollen sources are of the families Elaeagnaceae (Elaeagnus cf. latifolia, Euphorbiaceae (Croton, Fabaceae (Senna siamea and Cassia, Fagaceae (Lithocarpus and Castanopsis, and Lythraceae (Trapa which are mostly native to the region of Southeast Asia. The nesting architectural details should prove to be beneficial to beekeepers and researchers who are interested in trapping and studying X. nasalis, and the polylectic behavior of X. nasalis can be highly valuable for future crop pollination strategies, particularly for plants that require sonication of their poricidal anthers.

  19. Prescription patterns of Chinese herbal products for patients with sleep disorder and major depressive disorder in Taiwan.

    Science.gov (United States)

    Chen, Yi-Lin; Lee, Chien-Ying; Huang, Kuang-Hua; Kuan, Yu-Hsiang; Chen, Ming

    2015-08-02

    Chinese herbal products (CHPs) are commonly prescribed for sleep disorder and major depressive disorder (MDD). The aim of this study was to investigate the prescription patterns of CHPs and Western medicine for patients with these disorders in Taiwan, and analyze the frequency of using single herbs (SHs) and herbal formulas (HFs). In this retrospective population-based study secondary data analysis was performed using data from Taiwan's Longitudinal Health Insurance Database (LHID) between January 2007 and December 2011. In total, 1000,000 beneficiaries from the LHID were randomly selected from the 2010 registry for beneficiaries of the National Health Insurance Research Database. Patients with sleep disorder and MDD according to the International Classification of Diseases, Ninth Revision, Clinical Modification codes 307.40 and 311, respectively. Among a total of 11,030 patients with sleep disorder, 9619 used Western medicine, 1334 used CHPs, and 77 used both, Among a total of 11,571 patients with MDD, 11,389 used Western medicine, 131 used CHPs, and 51 used both. Regardless of disorder type, women were predominant The majority of the patients were aged 22-44 years, had a monthly income of NT$17,281-NT$22,800, and lived in an area with Level 1 and Level 2 urbanization. Of the patients with sleep disorder, 1411 had used CHPs and visited a clinic 5298 times on average. Of the patients with MDD, 182 had used CHPs and visited a clinic 755 times on average. The three most commonly used SHs and HFs were Ziziphi Spinosae Semen, Polygoni Multiflori Caulis, and Polygalae Radix, and Jia-Wei-Xiao-Yao-San, Suan-Zao-Ren-Tang, and Chai-Hu-Chia-Lung-Ku-Mu-Li-Tang, respectively. Chinese herbal products including SHs and HFs are prescribed for patients with sleep disorder and MDD. However, the efficacy and safety of CHPs for sleep disorder and MDD need to be further evaluated. Copyright © 2015. Published by Elsevier Ireland Ltd.

  20. EDITORIAL: Focus on Iron-Based Superconductors FOCUS ON IRON-BASED SUPERCONDUCTORS

    Science.gov (United States)

    Hosono, Hideo; Ren, Zhi-An

    2009-02-01

    Elastic theory for the vortex-lattice melting in iron-based high-Tc superconductors Q-H Chen, Q-M Nie, J-P Lv and T-C Au Yeung Electronic properties of LaO1-xFxFeAs in the normal state probed by NMR/NQR H-J Grafe, G Lang, F Hammerath, D Paar, K Manthey, K Koch, H Rosner, N J Curro, G Behr, J Werner, N Leps, R Klingeler, H-H Klauss, F J Litterst and B Büchner AFe2As2 (A = Ca, Sr, Ba, Eu) and SrFe2-xTMxAs2 (TM = Mn, Co, Ni): crystal structure, charge doping, magnetism and superconductivity Deepa Kasinathan, Alim Ormeci, Katrin Koch, Ulrich Burkhardt, Walter Schnelle, Andreas Leithe-Jasper and Helge Rosner Impurity states in a family of antiferromagnetic iron arsenides Qiang Han and Z D Wang Coherence-incoherence crossover in the normal state of iron oxypnictides and importance of Hund's rule coupling K Haule and G Kotliar Electronic structure of heavily electron-doped BaFe1.7Co0.3As2 studied by angle-resolved photoemission Y Sekiba, T Sato, K Nakayama, K Terashima, P Richard, J H Bowen, H Ding, Y-M Xu, L J Li, G H Cao, Z-A Xu and T Takahashi Absorption and photoemission spectroscopy of rare-earth oxypnictides T Kroll, F Roth, A Koitzsch, R Kraus, D R Batchelor, J Werner, G Behr, B Büchner and M Knupfer Superconductivity in LnFePO (Ln = La, Pr and Nd) single crystals R E Baumbach, J J Hamlin, L Shu, D A Zocco, N M Crisosto and M B Maple Unconventional pairing originating from disconnected Fermi surfaces in the iron-based superconductor Kazuhiko Kuroki, Seiichiro Onari, Ryotaro Arita, Hidetomo Usui, Yukio Tanaka, Hiroshi Kontani and Hideo Aoki Near-degeneracy of several pairing channels in multiorbital models for the Fe pnictides S Graser, T A Maier, P J Hirschfeld and D J Scalapino Investigation of superconducting gap structure in TbFeAsO0.9F0.1 using point contact Andreev reflection K A Yates, K Morrison, J A Rodgers, G B S Penny, J-W G Bos, J P Attfield and L F Cohen Competition of magnetism and superconductivity in underdoped (Ba1-xKx)Fe2As2 Marianne Rotter, Marcus

  1. PREFACE Turbulent Mixing and Beyond

    Science.gov (United States)

    Abarzhi, Snezhana I.; Gauthier, Serge; Niemela, Joseph J.

    2010-12-01

    for Theoretical Physics, Russia) E Bodenschatz (Max Plank Institute for Dynamics and Self-Organization, Germany) F Cattaneo (University of Chicago, USA) P Cvitanović (Georgia Institute of Technology, USA) S Cowley (Imperial College, UK) S Dalziel (DAMTP, University of Cambridge, UK) W S Don (Brown University, USA) R Ecke (Los Alamos National Laboratory, USA) H J Fernando (Arizona State University, USA) I Foster (University of Chicago, USA) S Gauthier (Commissariat à l'Energie Atomique, France) G A Glatzmaier (University of California at Santa Cruz, USA) J Glimm (State University of New York at Stony Brook, USA) W A Goddard III (California Institute of Technology, USA) J Jimenez (Universidad Politecnica de Madrid, Spain) L P Kadanoff (The University of Chicago, USA) D Q Lamb (The University of Chicago, USA) D P Lathrop (University of Maryland, USA) S Lebedev (Imperial College, UK) P Manneville (École Polytechnique, France) D I Meiron (California Institute of Technology, USA) P Moin (Stanford University, USA) A Nepomnyashchy (Technion, Israel) J Niemela (International Center for Theoretical Physics, Italy) K Nishihara (Institute for Laser Engineering, Osaka, Japan) S S Orlov (Stanford University, USA) S A Orszag (Yale University, USA) E Ott (University of Maryland, USA) N Peters (RWTH Aachen University, Germany) S B Pope (Cornell, USA) A Pouquet (University Corporation for Atmospheric Research, USA) B A Remington (Lawrence Livermore National Laboratory, USA) R Rosner (Argonne National Laboratory and University of Chicago, USA) A J Schmitt (Naval Research Laboratory, USA) C -W Shu (Brown University, USA) K R Sreenivasan (International Centre for Theoretical Physics, Italy) E Tadmor (University of Maryland, USA) Y C F Thio (US Department of Energy) A L Velikovich (Naval Research Laboratory, USA) V Yakhot (Boston University, USA) P K Yeung (Georgia Institute of Technology, USA) F A Williams (University of California at San Diego, USA) E Zweibel (University of Wisconsin

  2. Paleoclimate records at high latitude in Arctic during the Paleogene

    Science.gov (United States)

    Salpin, Marie; Schnyder, Johann; Baudin, François; Suan, Guillaume; Labrousse, Loïc; Popescu, Speranta; Suc, Jean-Pierre

    2015-04-01

    Paleoclimate records at high latitude in Arctic during the Paleogene SALPIN Marie1,2, SCHNYDER Johann1,2, BAUDIN François1,2, SUAN Guillaume3, LABROUSSE Loïc1,2, POPESCU Speranta4, SUC Jean-Pierre1,4 1: Sorbonne Universités, UPMC Univ Paris 06, UMR 7193, Institut des Sciences de la Terre Paris (iSTeP), F 75005, Paris, France 2: CNRS, UMR 7193, Institut des Sciences de la Terre Paris (iSTeP), F 75005 Paris, France 3: UCB Lyon 1, UMR 5276, LGLTPE, 69622 Villeurbanne Cedex, France 4: GEOBIOSTRATDATA.CONSULTING, 385 Route du Mas Rillier 69140 Rillieux la Pape, France The Paleogene is a period of important variations of the Earth climate system either in warming or cooling. The climatic optima of the Paleogene have been recognized both in continental and marine environment. This study focus on high latitudes of the northern hemisphere, in the Arctic Basin. The basin has had an influence on the Cenozoic global climate change according to its polar position. Is there a specific behaviour of the Arctic Basin with respect to global climatic stimuli? Are there possible mechanisms of coupling/decoupling of its dynamics with respect to the global ocean? To answer these questions a unique collection of sedimentary series of Paleogene age interval has been assembled from the Laurentian margin in Northern Yukon (Canada) and from the Siberian margin (New Siberian Islands). Selected continental successions of Paleocene-Eocene age were used to study the response of the Arctic system to known global events, e.g. the climatic optima of the Paleogene (the so-called PETM, ETM2 or the Azolla events). Two sections of Paleocene-Eocene age were sampled near the Mackenzie delta, the so-called Coal Mine (CoMi) and Caribou Hills (CaH) sections. The aim of the study is to precise the climatic fluctuations and to characterise the source rock potential of the basin, eventually linked to the warming events. This study is based on data of multi-proxy analyses: mineralogy on bulk and clay

  3. Boccia: factor de integración social y su significado en mujeres y hombres adscritos a la liga de parálisis cerebral de Bogotá

    Directory of Open Access Journals (Sweden)

    Karim Alvis

    2013-04-01

    Full Text Available Antecedentes. El Boccia es un deporte que debido a suscaracterísticas técnicas y metodológicas ya que es mixto, deprecisión y estrategia, permite la participación de individuoscon diversos tipos de limitaciones físicas, permitiendo de estaforma la integración social de los mismos, en un contexto deequidad, por lo cual ha tenido una gran acogida a nivel mundialsiendo catalogado como el deporte bandera de la AsociaciónInternacional de Deportes y Recreación para personas conParálisis Cerebral (CP-ISRA.Objetivo. Explorar los posibles significados que para mujeresy hombres en situación de discapacidad, tiene la práctica delBoccia como factor de integración social.Materiales y métodos. Esta investigación optó por el enfoqueCualitativo etnográfico, a través de las narrativas y experienciasde los protagonistas en este caso mujeres y hombres quehacen parte de la liga de Parálisis Cerebral de Bogotá- Boccia.Para estos efectos se utilizaron instrumentos como las entrevistassemiestructuradas, grupos focales y narrativas visuales.Resultados. El documento presenta un análisis de la percepcióny los alcances de la práctica de un deporte como el Bocciaen la integración social de los individuos desde las categoríasde los conceptos de solidaridad, autonomía, reconocimientode la diversidad, participación, universalidad, equidad, corresponsabilidad,efectividad, poder, libertad e identidad.Conclusión. Se concluye que los significados otorgados alBoccia como factor de integración social, por parte de losparticipantes en la Liga, en general se enmarcan de manerapositiva en las categorías conceptuales propuestas para suanálisis. Sin embargo, existe aún un alto desconocimiento de ladiscapacidad y de aceptación de las diferencias que se convierteen un factor limitante para una adecuada integración social.

  4. Projects of Earth Sciences Supported by National Natural Science Foundation of China

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    -shou 40001019\tGenetic Algorithm Approach to Automation and Intelligence of Map Name Placement\tFAN Hong 40001020\tEnvironmental Magnetic Study of Sedimentary Iron Cycling during Early Diagnoses\tZHANG Wei-guo 40001021\tModeling of Nitrogen and Water Input-yield-leaching Loss Response and the Nitrogen Transformation and Transportation\tZHANG Guo-liang 40001022\tThe Study on the Regional Differentiation of Lake Environment Response to Southwest Monsoon Climate\tPENG Jin-lan 40001023\tCritical Loads of Acid Deposition for Ecosystems and Their Exceedance in Regions Suffered from Acid Deposition in China\tTAO Fu-lu 40031010\tRegional Environmental Processes of Typical Trace Organic Pollutants\tTAO Shu 40061001\tAnalysis on the Structure of Karst Watershed and the Characteristics of Low Flow\tLIANG Hong 40061002\tThe Development Feature, Dynamic Mechanism and Coordination Research of Urban Concentric Region in West of Yunnan Province and Its Demonstration to Undeveloped, Minority Concentric Region of China\tWU Qi-yan 40061003\tThe REE Background Value and Its Influence on Soil Fertility in Laterite in the Hainan Island\tBI Hua 40061004\tStudies on the Mechanism of Soil Fertility Degradation and Techniques of Fertilization Under Arable Soils Condition in the "One-Jiang River and Two-He River" Region in Tibet\tCAI Xiao-bu 40061005\tA Study on Major Factors, Countermeasures and Mechanism of Bahia Grass Later-stage Degeneration at Rare-earth Tailings\tDONG Wen-da 40061006\tStudy on Soil Erosion and Land Use Security Pattern in Jinsha River Basin of Yunnan\tYANG Zi-sheng 40061007\tA Study on Environment Dynamic Chart of Southern Mountain Area of Ningxia under Eco-Restoration and Wide Development in West China\tSUI Yu-zhu 40061008\tThe Site Study of Environment Carrying Capacity for Tourism in Bita Reserve, Northwestern Yunnan\tYANG Gui-hua 40071001\tResearch on Sedimentary Processes and Varve Records of Lake Environment for Meromictic Lake on the Qinghai-Xizang (Tibet) Plateau\tLI Shi

  5. 3rd International Conference on Turbulent Mixing and Beyond

    Science.gov (United States)

    Abarzhi, Snezhana I.; Gauthier, Serge; Keane, Christopher J.; Niemela, Joseph J.

    2013-07-01

    , USA) • J Glimm (State University of New York at Stony Brook, USA) • W A Goddard III (California Institute of Technology, USA) • F Grinstein (Los Alamos National Laboratory, USA) • J Jimenez (Universidad Politecnica de Madrid, Spain) • L P Kadanoff (The University of Chicago, USA) • D Q Lamb (The University of Chicago, USA) • D P Lathrop (University of Maryland, USA) • S Lebedev (Imperial College, UK) • P Manneville (Ecole Polytechnique, France) • D I Meiron (California Institute of Technology, USA) • P Moin (Stanford University, USA) • A Nepomnyashchy (Technion, Israel) • J Niemela (International Center for Theoretical Physics, Italy) • K Nishihara (Institute for Laser Engineering, Osaka, Japan) • S S Orlov (Physical Optics Corporation, USA) • N Peters (RWTS, Aachen, Germany) • S B Pope (Cornell, USA) • A Pouquet (University Corporation for Atmospheric Research, USA) • B A Remington (Lawrence Livermore National Laboratory, USA) • R R Rosales (Massachusetts Institute of Technology, USA) • R Rosner (Argonne National Laboratory and University of Chicago, USA) • A J Schmitt (Naval Research Laboratory, USA) • C-W Shu (Brown University, USA) • K R Sreenivasan (New York University, USA) • E Tadmor (University of Maryland, USA) • A L Velikovich (Naval Research Laboratory, USA) • V Yakhot (Boston University, USA) • P K Yeung (Georgia Institute of Technology, USA) • F A Williams (University of California at San Diego, USA) • E Zweibel (University of Wisconsin, USA) We deeply appreciate the work of the Members of Steering Committee for Financial Support: • Snezhana I Abarzhi (University of Chicago, USA) • Serge Gauthier (Commissariat à l'Energie Atomique, France) • Joseph J Niemela (International Centre for Theoretical Physics, Italy) • Walter Gekelman (University of California, Los Angeles, USA) We thank the members of the Committee for the award 'Turbulent Mixing and Beyond for Youth': • Boris Galperin