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Sample records for studying reported functions

  1. Molecular studies of functional aspects of plant mitochondria. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Siedow, J.N.

    1992-03-03

    The goal of this research is to characterize the mechanism by which a protein encoded by mitochondrial genome of cms-T maize (URF13) interacts with a family of the compounds produced by certain fungi (T-toxins) to permeabilize biological membranes. The research carried out during the current funding period has focused on the structure of URF13, and the results support the validity of the three-helix model of URF13 and provide direct evidence for the oligomeric nature of at least some of the URF13 molecules in the membrane. In addition, the toxin binding studies have provided insight into the dynamic nature of the T-toxin:URF13 interaction and the extent to which Asp-39 is crucial to the interaction that leads to membrane pore formation. Additional knowledge of the structure of URF13 is needed if the nature of the interaction between URF13 and T-toxin to produce a hydrophilic pore within the membrane is to ultimately be understood.

  2. Parents with Psychosis: A Pilot Study Examining Self-Report Measures Related to Family Functioning.

    Science.gov (United States)

    Plant, Karen; Byrne, Linda; Barkla, Joanne; McLean, Duncan; Hearle, Jenny; McGrath, John

    2002-01-01

    Examines the utility of various self-report instruments related to family functioning in families where a parent has a psychotic disorder, and explores associations between these instruments and symptoms in the parent. There were significant associations between objective measures of negative symptoms and self-report scores related to problems in…

  3. Self-Reported Functional Status as Predictor of Observed Functional Capacity in Subjects with Early Osteoarthritis of the Hip and Knee : A Diagnostic Study in the CHECK Cohort

    NARCIS (Netherlands)

    Bieleman, H. J.; Reneman, M. F.; van Ittersum, M. W.; van der Schans, C. P.; Groothoff, J. W.; Oosterveld, F. G. J.

    2009-01-01

    Objectives Patients with hip or knee osteoarthritis (OA) may experience functional limitations in work settings. In the Cohort Hip and Cohort Knee study (CHECK) physical function was both self-reported and measured performance-based, using Functional Capacity Evaluation (FCE). Relations between

  4. Biotrans functional and technical description. Report of VIEWLS WP5, modelling studies

    International Nuclear Information System (INIS)

    Van Tilburg, X.; Egging, R.; Londo, H.M.

    2006-01-01

    The overall objectives of this project are to provide structured and clear data on the availability and performance of biofuels and to identify the possibilities and strategies towards large scale sustainable production, use and trading of biofuels for the transport sector in Europe, including Central and Eastern European Countries (CEEC). The report supplements the two other reports in the work package: 'Biofuel and Bio-energy implementation scenarios - final report of VIEWLS WP5' (2005) and 'VIEWLS modelling and analysis, technical data for biofuel production chains' (2005). This document contains a functional and technical description of the BioTrans model, accompanied by a description of the system. Section 2 contains a conceptual and functional description of the biofuel model. Section 3 describes the optimisation method in technical terms, discussing aspects like the target function and constraints used. Finally, section 4 discusses the input and output requirements for the BioTrans system

  5. A Study of a Collaborative Instructional Project Informed by Systemic Functional Linguistic Theory: Report Writing in Elementary Grades

    Science.gov (United States)

    Brisk, Maria Estela; Hodgson-Drysdale, Tracy; O'Connor, Cheryl

    2011-01-01

    This study examined the teaching of report writing in PreK-5 through the lens of systemic functional linguistics theory. Teachers were part of a university-public school collaboration that included professional development on teaching genres, text organization, and language features. Grounded in this knowledge, teachers explicitly taught report…

  6. Management functions, issues, and configuration alternatives: TO support a transportation management configuration study: [Final report

    International Nuclear Information System (INIS)

    1987-01-01

    The Office of Civilian Radioactive Waste Management (OCRWM) of the Department of Energy (DOE) is responsible for the safe transporation and disposal of spent nuclear fuel from utility-owned nuclear power generation reactors and high-level radioactive waste from both defense and civilian generators to long-term storage repositories. Given the volume, duration, and sensitivity of the operation, DOE is seeking not only the safest and best transportation system but also the most effective and resource-efficient management concept. Within the general guidelines of the Nuclear Waste Policy Act (NWPA) of 1982 calling for the fullest possible use of private industry contracts, this study examines the technical and administrative functions as well as the key issues to be addressed in the formation of a management structure. In order to stand alone as a comprehensive treatment of the total requirement, the material contained in many seperate and sometimes divergent DOE/OCRWM documents was evaluated and is compiled here. An attempt was made to succinctly define the nature of the problem, the objectives and scope of both the operating and management systems, and then to dissect the functions required in order to meet the objectives and operating functions are listed and described

  7. Brief Report: Anomalous Neural Deactivations and Functional Connectivity during Receptive Language in Autism Spectrum Disorder--A Functional MRI Study

    Science.gov (United States)

    Karten, Ariel; Hirsch, Joy

    2015-01-01

    Neural mechanisms that underlie language disability in autism spectrum disorder (ASD) have been associated with reduced excitatory processes observed as positive blood oxygen level dependent (BOLD) responses. However, negative BOLD responses (NBR) associated with language and inhibitory processes have been less studied in ASD. In this study,…

  8. Substantiated Reports of Child Maltreatment From the Canadian Incidence Study of Reported Child Abuse and Neglect 2008: Examining Child and Household Characteristics and Child Functional Impairment.

    Science.gov (United States)

    Afifi, Tracie O; Taillieu, Tamara; Cheung, Kristene; Katz, Laurence Y; Tonmyr, Lil; Sareen, Jitender

    2015-07-01

    Identifying child and household characteristics that are associated with specific child maltreatment types and child functional impairment are important for informing prevention and intervention efforts. Our objectives were to examine the distribution of several child and household characteristics among substantiated child maltreatment types in Canada; to determine if a specific child maltreatment type relative to all other types was associated with increased odds of child functional impairment; and to determine which child and household characteristics were associated with child functional impairment. Data were from the Canadian Incidence Study of Reported Child Abuse and Neglect (collection 2008) from 112 child welfare sites across Canada (n = 6163 children). Physical abuse, sexual abuse, and emotional maltreatment were highly prevalent among children aged 10 to 15 years. For single types of child maltreatment, the highest prevalence of single-parent homes (50.6%), social assistance (43.0%), running out of money regularly (30.7%), and unsafe housing (30.9%) were reported for substantiated cases of neglect. Being male, older age, living in a single-parent home, household running out of money, moving 2 or more times in the past year, and household overcrowding were associated with increased odds of child functional impairment. More work is warranted to determine if providing particular resources for single-parent families, financial counselling, and facilitating adequate and stable housing for families with child maltreatment histories or at risk for child maltreatment could be effective for improving child functional outcomes.

  9. Substantiated Reports of Child Maltreatment From the Canadian Incidence Study of Reported Child Abuse and Neglect 2008: Examining Child and Household Characteristics and Child Functional Impairment

    Science.gov (United States)

    Afifi, Tracie O; Taillieu, Tamara; Cheung, Kristene; Katz, Laurence Y; Tonmyr, Lil; Sareen, Jitender

    2015-01-01

    Objective: Identifying child and household characteristics that are associated with specific child maltreatment types and child functional impairment are important for informing prevention and intervention efforts. Our objectives were to examine the distribution of several child and household characteristics among substantiated child maltreatment types in Canada; to determine if a specific child maltreatment type relative to all other types was associated with increased odds of child functional impairment; and to determine which child and household characteristics were associated with child functional impairment. Method: Data were from the Canadian Incidence Study of Reported Child Abuse and Neglect (collection 2008) from 112 child welfare sites across Canada (n = 6163 children). Results: Physical abuse, sexual abuse, and emotional maltreatment were highly prevalent among children aged 10 to 15 years. For single types of child maltreatment, the highest prevalence of single-parent homes (50.6%), social assistance (43.0%), running out of money regularly (30.7%), and unsafe housing (30.9%) were reported for substantiated cases of neglect. Being male, older age, living in a single-parent home, household running out of money, moving 2 or more times in the past year, and household overcrowding were associated with increased odds of child functional impairment. Conclusions: More work is warranted to determine if providing particular resources for single-parent families, financial counselling, and facilitating adequate and stable housing for families with child maltreatment histories or at risk for child maltreatment could be effective for improving child functional outcomes. PMID:26175390

  10. FBI fingerprint identification automation study: AIDS 3 evaluation report. Volume 9: Functional requirements

    Science.gov (United States)

    1980-01-01

    The current system and subsystem used by the Identification Division are described. System constraints that dictate the system environment are discussed and boundaries within which solutions must be found are described. The functional requirements were related to the performance requirements. These performance requirements were then related to their applicable subsystems. The flow of data, documents, or other pieces of information from one subsystem to another or from the external world into the identification system is described. Requirements and design standards for a computer based system are presented.

  11. HT-29 and Caco-2 Reporter Cell Lines for Functional Studies of Nuclear Factor Kappa B Activation

    Directory of Open Access Journals (Sweden)

    Giuliana Mastropietro

    2015-01-01

    Full Text Available The NF-κB is a transcription factor which plays a key role in regulating biological processes. In response to signals, NF-κB activation occurs via phosphorylation of its inhibitor, which dissociates from the NF-κB dimer allowing the translocation to the nucleus, inducing gene expression. NF-κB activation has direct screening applications for drug discovery for several therapeutic indications. Thus, pathway-specific reporter cell systems appear as useful tools to screen and unravel the mode of action of probiotics and natural and synthetic compounds. Here, we describe the generation, characterization, and validation of human epithelial reporter cell lines for functional studies of NF-κB activation by different pro- and anti-inflammatory agents. Caco-2 and HT-29 cells were transfected with a pNF-κB-hrGFP plasmid which contains the GFP gene under the control of NF-κB binding elements. Three proinflammatory cytokines (TNF-α, IL-1β, and LPS were able to activate the reporter systems in a dose-response manner, which corresponds to the activation of the NF-κB signaling pathway. Finally, the reporter cell lines were validated using lactic acid bacteria and a natural compound. We have established robust Caco-2-NF-κB-hrGFP and HT-29-NF-κB-hrGFP reporter cell lines which represent a valuable tool for primary screening and identification of bacterial strains and compounds with a potential therapeutic interest.

  12. A Study of the Speed of Understanding Sentences as a Function of Sentence Structure. Final Report.

    Science.gov (United States)

    Halamandaris, Pandelis G.

    On the basis of the grammatical theory developed by Noam Chomsky, it is reasonable to presume that the different parts of a sentence may not all be understood with equal facility and speed. One purpose of this study was to determine whether some of the grammatical relations within a sentence were understood more readily than others. Sentences of…

  13. B Plant function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and a function hierarchy chart that describe what needs to be performed to deactivate B Plant

  14. A clinical observational study on patient-reported outcomes, hip functional performance and return to sports activities in hip arthroscopy patients

    NARCIS (Netherlands)

    Tijssen, M.P.W.; Cingel, R.E. van; Visser, E de; Nijhuis-Van der Sanden, M.W.G.

    2016-01-01

    OBJECTIVES: To describe data of short- and midterm results of hip arthroscopy patients based on patient-reported hip function, hip functional performance and return to sports activities. DESIGN: Observational cohort study. SETTING: Sports medical center. PARTICIPANTS: 37 recreational athletes (21

  15. Self-reported physical activity and lung function two months after cardiac surgery--a prospective cohort study.

    Science.gov (United States)

    Jonsson, Marcus; Urell, Charlotte; Emtner, Margareta; Westerdahl, Elisabeth

    2014-03-28

    Physical activity has well-established positive health-related effects. Sedentary behaviour has been associated with postoperative complications and mortality after cardiac surgery. Patients undergoing cardiac surgery often suffer from impaired lung function postoperatively. The association between physical activity and lung function in cardiac surgery patients has not previously been reported. Patients undergoing cardiac surgery were followed up two months postoperatively. Physical activity was assessed on a four-category scale (sedentary, moderate activity, moderate regular exercise, and regular activity and exercise), modified from the Swedish National Institute of Public Health's national survey. Formal lung function testing was performed preoperatively and two months postoperatively. The sample included 283 patients (82% male). Two months after surgery, the level of physical activity had increased (p < 0.001) in the whole sample. Patients who remained active or increased their level of physical activity had significantly better recovery of lung function than patients who remained sedentary or had decreased their level of activity postoperatively in terms of vital capacity (94 ± 11% of preoperative value vs. 91 ± 9%; p = 0.03), inspiratory capacity (94 ± 14% vs. 88 ± 19%; p = 0.008), and total lung capacity (96 ± 11% vs. 90 ± 11%; p = 0.01). An increased level of physical activity, compared to preoperative level, was reported as early as two months after surgery. Our data shows that there could be a significant association between physical activity and recovery of lung function after cardiac surgery. The relationship between objectively measured physical activity and postoperative pulmonary recovery needs to be further examined to verify these results.

  16. Automatic Incrementalization of Functional Reports

    DEFF Research Database (Denmark)

    Larsen, Ken Friis; Henglein, Fritz

    An essential part of many organisations is the ability to provide the users and decision makers with reports on key data based on large amounts data, and these reports should be delivered in a timely manner to stay relevant. To get the desired performance the programs generating these reports...

  17. The association between alcohol drinking and self-reported mental and physical functioning: a prospective cohort study among City of Helsinki employees.

    Science.gov (United States)

    Salonsalmi, Aino; Rahkonen, Ossi; Lahelma, Eero; Laaksonen, Mikko

    2017-05-04

    Alcohol drinking is associated with ill health but less is known about its contribution to overall functioning. We aimed to examine whether alcohol drinking predicts self-reported mental and physical functioning 5-7 years later. A prospective cohort study. Helsinki, Finland. 40-year-old to 60-year-old employees of the City of Helsinki (5301 women and 1230 men) who participated in a postal survey in 2000-2002 and a follow-up survey in 2007. Mental and physical functioning measured by the Short Form 36 Health Survey. Alcohol drinking was differently associated with mental and physical functioning. Heavy average drinking, binge drinking and problem drinking were all associated with subsequent poor mental functioning except for heavy average drinking among men, whereas only problem drinking was associated with poor physical functioning. Also, non-drinking was associated with poor physical functioning. Problem drinking was the drinking habit showing most widespread and strongest associations with health functioning. The associations between problem drinking and poor mental functioning and with poor physical functioning among women remained after adjusting for baseline mental functioning, sociodemographic factors, working conditions and other health behaviours. Alcohol drinking is associated especially with poor mental functioning. Problem drinking was the drinking habit strongest associated with poor health functioning. The results call for early recognition and prevention of alcohol problems in order to improve health functioning among employees. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  18. Functional studies using NMR

    International Nuclear Information System (INIS)

    McCready, V.R.; Leach, M.O.; Sutton; Ell, P.

    1986-01-01

    The object of this book is to discuss and evaluate an area of Nuclear Magnetic Resonance which to date has been less emphasized than it might be, namely the use of NMR for functional studies. The book commences with a discussion of the areas in which the NMR techniques might be needed due to deficiencies in other techniques. The physics of NMR especially relating to functional measurement are then explained. Technical factors in producing functional images are discussed and the use of paramagnetic substances for carrying out flow studies are detailed. Particular attention is paid to specific studies in the various organs. The book ends with a survey of imaging in each organ and the relation of NMR images to other techniques such as ultrasound, nuclear medicine and X-rays

  19. Postural balance and self-reported functional ability in 75-year-old men and women: a cross-national comparative study

    DEFF Research Database (Denmark)

    Era, P; Avlund, K; Jokela, J

    1997-01-01

    OBJECTIVE: To study postural balance in relation to self-reported functional ability (mobility and ADL) and general physical activity in elderly men and women living in three different Nordic environments. PARTICIPANTS: A random sample of 448 men and 556 women from among the 75-year-old residents...... of forces than in the mediolateral direction. The performance in the balance tests was also significantly better among the subjects reporting a higher level of general physical activity than in their less active counterparts. Physical activity and than in their less active counterparts. Physical activity...... in Glostrup, Denmark, and Göteborg, Sweden, and all the residents of relevant age (127 men and 261 women) in Jyväskylä, Finland. MEASUREMENTS: Assessment of postural balance with eyes open and closed using a piezoelectric force platform. A structured interview on self-reported functional ability and physical...

  20. Improved level of function in an individual with Carcinoma of the pyriform sinus undergoing radiotherapy: A case report study

    Directory of Open Access Journals (Sweden)

    A K Akhil

    2017-01-01

    Full Text Available A 72-year-old female with a history of cough and difficulty in swallowing was admitted in KLE Cancer Hospital and was diagnosed with carcinoma of the pyriform sinus, where she was undergoing radiotherapy and was referred for physiotherapy. On examination, she had chest secretion, cough, breathlessness, and generalized body weakness that led to functional limitations. Pre- and postfunctional assessment was done with the help of Functional independence measure (FIMS scale. A 10-day physiotherapy intervention was given and post intervention evaluation showed an increased functional level.

  1. Visual disability, visual function, and myopia among rural chinese secondary school children: the Xichang Pediatric Refractive Error Study (X-PRES)--report 1.

    Science.gov (United States)

    Congdon, Nathan; Wang, Yunfei; Song, Yue; Choi, Kai; Zhang, Mingzhi; Zhou, Zhongxia; Xie, Zhenling; Li, Liping; Liu, Xueyu; Sharma, Abhishek; Wu, Bin; Lam, Dennis S C

    2008-07-01

    To evaluate visual acuity, visual function, and prevalence of refractive error among Chinese secondary-school children in a cross-sectional school-based study. Uncorrected, presenting, and best corrected visual acuity, cycloplegic autorefraction with refinement, and self-reported visual function were assessed in a random, cluster sample of rural secondary school students in Xichang, China. Among the 1892 subjects (97.3% of the consenting children, 84.7% of the total sample), mean age was 14.7 +/- 0.8 years, 51.2% were female, and 26.4% were wearing glasses. The proportion of children with uncorrected, presenting, and corrected visual disability (visual disability when tested without correction, 98.7% was due to refractive error, while only 53.8% (414/770) of these children had appropriate correction. The girls had significantly (P visual disability and myopia visual function (ANOVA trend test, P Visual disability in this population was common, highly correctable, and frequently uncorrected. The impact of refractive error on self-reported visual function was significant. Strategies and studies to understand and remove barriers to spectacle wear are needed.

  2. Functional studies using NMR

    International Nuclear Information System (INIS)

    McCready, V.R.; Leach, M.; Ell, P.J.

    1987-01-01

    This volume is based on a series of lectures delivered at a one-day teaching symposium on functional and metabolic aspects of NMR measurements held at the Middlesex Hospital Medical School on 1st September 1985 as a part of the European Nuclear Medicine Society Congress. Currently the major emphasis in medical NMR in vivo is on its potential to image and display abnormalities in conventional radiological images, providing increased contrast between normal and abnormal tissue, improved definition of vasculature, and possibly an increased potential for differential diagnosis. Although these areas are undeniably of major importance, it is probable that NMR will continue to complement conventional measurement methods. The major potential benefits to be derived from in vivo NMR measurements are likely to arise from its use as an instrument for functional and metabolic studies in both clinical research and in the everyday management of patients. It is to this area that this volume is directed

  3. Thyroid function study

    International Nuclear Information System (INIS)

    Rocha, A.F.G. da

    1976-01-01

    A short revision of thyroid physiology is done. The radioisotopes of common use in thyroid investigation and the choice of the most appropriated ones are discussed. A table showing radioisotopes frequently used in this study, with their main characteristics is presented. Among several isotopic assays in thyroid propaedeutics, those that refer to the function study, topographic studies and tests 'in vitro' are pointed out. Exploration methods 'in vivo' are treated, such as: thyroid uptake; urinary excretion; thyroid scintigraphy, with scintigraphic imagings; stimulation test by TSH; suppression test; pbi; clearance test with perchlorate; iodine deficiency test and thyroid study with technetium. 'In vitro' proofs like triiodothyronine (T 3 ) and thyroxine (T 4 ) assays, as well as free thyroxine index, are treated. At last, the therapeutics by Iodine 131 is commented and emphasis is given to its application on the treatment of hyperthyroidism and thyroid carcinoma [pt

  4. Factors influencing observed and self-reported functional ability in women with chronic widespread pain: A cross-sectional study

    DEFF Research Database (Denmark)

    Amris, Kirstine; Wæhrens, Eva Ejlersen; Stockmarr, Anders

    2014-01-01

    -sectional with systematic data collection in a clinical setting. Subjects: A total of 257 consecutively enrolled women with chronic widespread pain. Methods: Multidimensional assessment using self-report and observation-based assessment tools identified to cover ICF categories included in the brief ICF Core Set for chronic...

  5. A functional language for specifying business reports

    DEFF Research Database (Denmark)

    Bahr, Patrick

    2011-01-01

    We describe our work on developing a functional domain specificlanguage for specifying business reports. The report specificationlanguage is part of a novel enterprise resource planing system basedon the idea of a providing a lean core system that is highlycustomisable via a variety of domain...... specific languages....

  6. A Functional Language for Specifying Business Reports

    DEFF Research Database (Denmark)

    Bahr, Patrick

    2011-01-01

    We describe our work on developing a functional domain specific language for specifying business reports. The report specification language is part of a novel enterprise resource planing system based on the idea of a providing a lean core system that is highly customisable via a variety of domain...

  7. Reporting of teratology studies.

    Science.gov (United States)

    Barrow, Paul C; Reynaud, Lucie

    2013-01-01

    The regulatory toxicology report is an unusual document that requires a particular skill to write. The report must be clear, accurate, concise, and focused. A clear and direct writing style is required. The end-users of the report will hope to find the information they seek with as little effort as possible. Few, or none, will read the entire document. The author should aim to appease the user by obliging him to read as little text and turn as few pages as possible. This chapter gives tips and guidance on how to present the experimental data and write the narrative text in the final study report for a teratology study.

  8. Cardiac function studies

    International Nuclear Information System (INIS)

    Horn, H.J.

    1986-01-01

    A total of 27 patients were subjected tointramyocardial sequential scintiscanning (first pass) using 99m-Tc human serum albumin. A refined method is described that is suitable to analyse clinically relevant parameters like blood volume, cardiac output, ejection fraction, stroke volume, enddiastolic and endsystolic volumes as well as pulmonal transition time and uses a complete camaracomputer system adapted to the requirements of a routine procedure. Unless there is special hardware available, the method does not yet appear mature enough to be put into general practice. Its importance recently appeared in a new light due to the advent of particularly shortlived isotopes. For the time being, however, ECG-triggered equilibrium studies are to be preferred for cardiac function tests. (TRV) [de

  9. The Consequence of a Medial Ankle Sprain on Physical and Self-reported Functional Limitations: A Case Study Over a 5-Month Period.

    Science.gov (United States)

    Terada, Masafumi; Thomas, Abbey C; Pietrosimone, Brian; Hiller, Claire E; Bowker, Samantha; Gribble, Phillip A

    2015-10-01

    Case report. Little evidence exists about impairments and perceived disability following eversion injury to the deltoid ligament. This case study prospectively examined the neuromuscular, biomechanical, and psychological consequences of a case of a medial ankle sprain. A recreationally active man with a history of a lateral ankle sprain (grade I) was participating in a university Institutional Review Board-approved research study examining the neuromuscular and mechanical characteristics associated with chronic ankle instability. Twenty-two days after the testing session, the participant sustained an eversion injury to his left ankle while playing basketball. Outcomes The outcomes of this case are presented using the International Classification of Functioning, Disability and Health model. Outcome variables were assessed at preinjury (medial ankle sprain), 3 months postinjury, and 5 months postinjury. Measurements included neural excitability of the soleus, balance assessment, joint stability, and psychological assessments. Data from this case study revealed that a medial ankle sprain reduces joint mobility and alters neural excitability of the soleus, with concurrent deficits in balance and self-reported function. These impairments forced the participant to downgrade his physical activity lifestyle up to 5 months postinjury. These data suggest the need for the development of intervention strategies to address impairments in neural excitability and joint mobility at the ankle to help patients meet the goal of maintaining long-term joint health. Prognosis, level 4.

  10. Self-Reported Fear Predicts Functional Performance and Second ACL Injury After ACL Reconstruction and Return to Sport: A Pilot Study.

    Science.gov (United States)

    Paterno, Mark V; Flynn, Kaitlyn; Thomas, Staci; Schmitt, Laura C

    Outcomes after anterior cruciate ligament reconstruction (ACLR) are highly variable. Previous studies have failed to report the relationship between fear, objective measures of function, and reinjury rates. The purpose of this study was to determine whether fear was related to functional performance measures and risk of second ACL injury after ACLR and return to sport (RTS). Fear will be associated with performance on functional testing and second ACL injury rate. Prospective cohort study. Level 2. A total of 40 patients cleared to RTS after ACLR completed the Tampa Scale of Kinesiophobia (TSK-11), hop testing, and quadriceps strength testing, bilaterally. Patients were tracked for 12 months after RTS to identify the incidence of second ACL injury. Chi-square analyses determined whether patients with high fear (TSK-11, ≥17) were more likely to have lower levels of activity, greater asymmetry on functional testing, and higher reinjury rates. Patients with greater fear on the TSK-11 (≥17) at RTS were 4 times (odds ratio [OR], 3.73; 95% CI, 0.98-14.23) more likely to report lower levels of activity, 7 times (OR, 7.1; 95% CI, 1.5-33.0) more likely to have a hop limb symmetry lower than 95%, and 6 times (OR, 6.0; 95% CI, 1.3-27.8) more likely to have quadriceps strength symmetry lower than 90%. Patients who went on to suffer an ipsilateral second ACL injury had a greater TSK-11 score at the time of RTS (mean, 19.8 ± 4.0) than those who did not suffer a second ACL injury (mean, 16.4 ± 3.6) ( P = 0.03). Patients with a TSK-11 score of 19 or greater at the time of RTS were 13 times (relative risk, 13.0; 95% CI, 2.1-81.0) more likely to suffer a second ACL tear within 24 months after RTS. Patients with greater self-reported fear were less active, presented with lower single-leg hop performance and isometric quadriceps strength, and had an increased risk of suffering a second ACL injury in the 24 months after RTS. Self-reported fear of movement/reinjury after ACLR at

  11. Task Requirements, Task Representation, and Self-Reported Citation Functions: An Exploratory Study of a Successful L2 Student's Writing

    Science.gov (United States)

    Petric, Bojana; Harwood, Nigel

    2013-01-01

    This mixed-method study investigates the citation behaviour of a successful L2 postgraduate management student, Sofie, in two pieces of writing, written in response to two assignment tasks in two management modules. The tasks belonged to the same assignment type, but differed in the level of direction provided: one was a directed task, accompanied…

  12. Study of the Career Intern Program. Final Technical Report--Task C: Program Dynamics: Structure, Function, and Interrelationships.

    Science.gov (United States)

    Fetterman, David M.

    A study identified causal linkages and basic interrelationships among components of the Career Intern Program (CIP) and observed outcomes. (The CIP is an alternative high school designed to enable disadvantaged and alienated dropouts or potential dropouts to earn regular high school diplomas, to prepare them for meaningful employment or…

  13. Construct validity of patient-reported outcome instruments in US adults with hemophilia: results from the Pain, Functional Impairment, and Quality of life (P-FiQ study

    Directory of Open Access Journals (Sweden)

    Batt K

    2017-08-01

    Full Text Available Katharine Batt,1 Michael Recht,2 David L Cooper,3 Neeraj N Iyer,3 Christine L Kempton4 1Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, 2The Hemophilia Center, Oregon Health & Science University, Portland, OR, 3Novo Nordisk Inc., Plainsboro, NJ, 4Departments of Pediatrics and Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA Background: People with hemophilia (PWH experience frequent joint bleeding, resulting in pain and functional impairment. Generic and disease-specific patient-reported outcome (PRO instruments have been used in clinical studies, but rarely in the comprehensive hemophilia care setting. Objective: The objective of this study was to assess construct validity of PRO instruments measuring pain, functional impairment, and health-related quality of life in US PWH with a history of joint pain/bleeding. Methods: Adult male PWH completed 4 PRO instruments (EQ-5D-5L with visual analog scale, Brief Pain Inventory v2 Short Form [BPI], SF-36v2, Hemophilia Activities List [HAL] and underwent a musculoskeletal examination (Hemophilia Joint Health Score v2.1 [HJHS]. Construct validity between index and domain scores was evaluated by Pearson product-moment correlation coefficient. Results: A total of 381 PWH were enrolled. EQ-5D-5L Mobility correlated with BPI, SF-36v2, and HAL domains related to pain, physical function, and activity of the lower extremities. EQ-5D-5L Self-Care correlated only with HAL Self-Care. EQ-5D-5L Usual Activities correlated with BPI Pain Interference and domains within SF-36v2 and HAL related to pain and physical function/activities (particularly those involving the lower extremities. EQ-5D-5L Pain/Discomfort correlated with Bodily Pain and Physical Summary on SF-36v2, HAL Overall Activity, and all BPI pain domains. EQ-5D-5L Anxiety/Depression correlated with social/emotional/mental aspects of SF-36v2. On BPI, most pain domains correlated with Bodily

  14. Randomized controlled trial of increasing physical activity on objectively measured and self-reported cognitive functioning among breast cancer survivors: The memory & motion study.

    Science.gov (United States)

    Hartman, Sheri J; Nelson, Sandahl H; Myers, Emily; Natarajan, Loki; Sears, Dorothy D; Palmer, Barton W; Weiner, Lauren S; Parker, Barbara A; Patterson, Ruth E

    2018-01-01

    Increasing physical activity can improve cognition in healthy and cognitively impaired adults; however, the benefits for cancer survivors are unknown. The current study examined a 12-week physical activity intervention, compared with a control condition, on objective and self-reported cognition among breast cancer survivors. Sedentary breast cancer survivors were randomized to an exercise arm (n = 43) or a control arm (n = 44). At baseline and at 12 weeks, objective cognition was measured with the National Institutes of Health Cognitive Toolbox, and self-reported cognition using the Patient-Reported Outcomes Measurement Information System scales. Linear mixed-effects regression models tested intervention effects for changes in cognition scores. On average, participants (n = 87) were aged 57 years (standard deviation, 10.4 years) and were 2.5 years (standard deviation, 1.3 years) post surgery. Scores on the Oral Symbol Digit subscale (a measure of processing speed) evidenced differential improvement in the exercise arm versus the control arm (b = 2.01; P cognition were not statistically significant but were suggestive of potential group differences. Time since surgery moderated the correlation, and participants who were ≤2 years post surgery had a significantly greater improvement in Oral Symbol Digit score (exercise vs control (b = 4.00; P 2 years postsurgery (b = -1.19; P = .40). A significant dose response was observed with greater increased physical activity associated with objective and self-reported cognition in the exercise arm. The exercise intervention significantly improved processing speed, but only among those who had been diagnosed with breast cancer within the past 2 years. Slowed processing speed can have substantial implications for independent functioning, supporting the potential importance of early implementation of an exercise intervention among patients with breast cancer. Cancer 2018;124:192-202. © 2017

  15. Functional Fitness and Self-Reported Quality of Life of Older Women Diagnosed with Knee Osteoarthrosis: A Cross-Sectional Case Control Study

    Directory of Open Access Journals (Sweden)

    Paula Andréa Malveira Cavalcante

    2015-01-01

    Full Text Available Aim. Utilizing a cross-sectional case control design, the aim of this study was to evaluate the functional fitness and self-reported quality of life differences in older people diagnosed with knee osteoarthrosis (O who participated in health promotion groups. Methods. Ninety older women were distributed into two groups: control without O of the knee (C, n=40 and a group diagnosed with primary and secondary knee O with grade II or higher, with definite osteophytes (OA, n=50. Functional fitness was evaluated by specific tests, and the time spent in physical activity and quality of life was evaluated by the IPAQ and WHOQOL (distributed in four domains: physical: P, psychological: PS, social: S, and environmental: E domain questionnaires. Results. No differences were found between ages of groups (C: 66±7; OA: 67±9; years. The values of the chair stand test (rep in the OA (13±5 group were different when compared to C group (22±5. For the 6-minute walk test (meters, the values obtained for the C (635±142 were higher (P<0.01 than the OA (297±143 group. The time spent in physical activity (min was greater (P<0.001 in the control (220±12 group compared to OA (100±10 group. Higher values (P<0.001 in all domains were found in the C (P: 69±16, PS: 72±17, S: 67±15, E: 70±15 group compared to OA (P: 48±7, PS: 43±8, S: 53±13, E: 47±14 group. Conclusion. Our data suggests that knee O, in older women, can promote a decline in time spent performing physical activity and functional fitness with decline in quality of life with an increase in sitting time.

  16. OBSESSIONS: CASE REPORT STUDY

    Directory of Open Access Journals (Sweden)

    Miloš Židanik

    2004-01-01

    Full Text Available Background. Obsessions are one of the most refractory psychiatric disorders. The therapeutic guidelines include a psychopharmacotherapy and the use of behavioural and supportive psychotherapy.Methods. This case report study presents a patient with a homicide obsessions at the forefront and narcissistic personality disorder in background. The use of analytical oriented psychotherapy, which helped to resolve axis-1 symptoms, is described.Conclusions. In the therapy of patients it is important to have the knowledge about the national therapeutic guidelines and critical distance toward them as well. Which therapy to use should be decided by the individual patient’s needs.

  17. 308 Building deactivation function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and a function hierarchy chart that describes what needs to be performed to deactivate the 308 Building

  18. PUREX Plant deactivation function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and a function hierarchy chart that describe what needs to be performed to deactivate PUREX

  19. 309 Building deactivation function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and a function hierarchy chart that describe what needs to be performed to deactivate the 309 Building

  20. FFTF Plant transition function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and function hierarchy charts that describe what needs to be performed to deactivate FFTF

  1. Reference values of the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being: a report from the American Cancer Society's studies of cancer survivors.

    Science.gov (United States)

    Munoz, Alexis R; Salsman, John M; Stein, Kevin D; Cella, David

    2015-06-01

    Health-related quality of life measures are common in oncology research, trials, and practice. Spiritual well-being has emerged as an important aspect of health-related quality of life and the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being; The 12-item Spiritual Well-Being Scale (FACIT-Sp-12) is the most widely used measure of spiritual well-being among those with cancer. However, there is an absence of reference values with which to facilitate the interpretation of scores in research and clinical practice. The objective of the current study was to provide FACIT-Sp-12 reference values from a representative sample of adult cancer survivors. As part of the American Cancer Society's Study of Cancer Survivors-II, a national cross-sectional study of cancer survivors (8864 survivors) completed questionnaires assessing demographic characteristics, clinical information, and the FACIT-Sp-12. Scores were calculated and summarized by FACIT-Sp-12 subscale and total scores across age, sex, race/ethnicity, time after treatment, and cancer type. Student t tests for independent samples found that women reported significantly higher FACIT-Sp-12 scores (P<.001). Analyses of variance found significant main effects for FACIT-Sp-12 scores by age (P<.01), race/ethnicity (P<.05), and cancer type (P<.001). Post hoc comparisons revealed that older adults (those aged 60-69 years and 70-79 years) and black non-Hispanic individuals reported the highest FACIT-Sp-12 scores compared with those aged 18 to 39 years (P<.05; Cohen d [an effect size used to indicate the standardized difference between 2 means], 0.20-0.50) and white non-Hispanic individuals (P<.05; Cohen d, 0.02-0.62), respectively. All other significant main effects were small in magnitude (effect size range, 0.001-0.032). These data will aid in the interpretation of the magnitude and meaning of FACIT-Sp-12 scores, and allow for comparisons of scores across studies. © 2015 American Cancer Society.

  2. A population-based study of physical function and risk for elder abuse reported to social service agency: findings from the Chicago health and aging project.

    Science.gov (United States)

    Dong, XinQi; Simon, Melissa; Evans, Denis

    2014-10-01

    We examined the association between physical function and the risk for reported elder abuse. In the Chicago Health and Aging Project (N = 8,932), 238 participants had reported elder abuse. The independent variable was objectively assessed physical function using both directly observed physical performance testing and self-reported physical function (Katz activity of daily living scale, Nagi physical activity scale, and Rosow Breslau mobility scales). Outcomes were elder abuse and specific subtypes of elder abuse. After adjusting for confounders, lower levels of physical performance testing (OR, 2.71[1.58-4.64]), Katz impairment (OR, 1.84[1.29-2.59]), Nagi impairment (OR, 1.65[1.15-2.37]) and Rosow Breslau (OR, 1.76[1.26-2.47]) were associated with increased risk for elder abuse. Lowest levels of physical performance testing were associated with increased risk for psychological abuse (OR, 2.69[1.27-5.71]), caregiver neglect (OR, 2.66[1.22-5.79]), and financial exploitation (OR, 2.35 [1.21-4.55]). Our results may have important implications to healthcare professional, social services and other disciplines to prevent and treat elder abuse. © The Author(s) 2012.

  3. Functional visual fields: relationship of visual field areas to self-reported function.

    Science.gov (United States)

    Subhi, Hikmat; Latham, Keziah; Myint, Joy; Crossland, Michael D

    2017-07-01

    The aim of this study is to relate areas of the visual field to functional difficulties to inform the development of a binocular visual field assessment that can reflect the functional consequences of visual field loss. Fifty-two participants with peripheral visual field loss undertook binocular assessment of visual fields using the 30-2 and 60-4 SITA Fast programs on the Humphrey Field Analyser, and mean thresholds were derived. Binocular visual acuity, contrast sensitivity and near reading performance were also determined. Self-reported overall and mobility function were assessed using the Dutch ICF Activity Inventory. Greater visual field loss (0-60°) was associated with worse self-reported function both overall (R 2 = 0.50; p function (R 2 = 0.61, p function in multiple regression analyses. Superior and inferior visual field areas related similarly to mobility function (R 2 = 0.56, p function in multiple regression analysis. Mean threshold of the binocular visual field to 60° eccentricity is a good predictor of self-reported function overall, and particularly of mobility function. Both the central (0-30°) and peripheral (30-60°) mean threshold are good predictors of self-reported function, but the peripheral (30-0°) field is a slightly better predictor of mobility function, and should not be ignored when considering functional consequences of field loss. The inferior visual field is a slightly stronger predictor of perceived overall and mobility function than the superior field. © 2017 The Authors Ophthalmic & Physiological Optics © 2017 The College of Optometrists.

  4. Functioning lipoadenoma of the parathyroid: Case report and literature review

    International Nuclear Information System (INIS)

    Bleiweiss, I.J.; Harpaz, N.; Strauchen, J.A.; Wagner, R.; Biller, H.F.

    1989-01-01

    Lipoadenoma of the parathyroid gland is a rare histologic variant of parathyroid adenoma that is usually functional and associated with clinical hyperparathyroidism. We report a case in which a radiolabeled thallium scan failed to demonstrate evidence of an adenoma, presumably because of the tumor's high fat content. The literature concerning this entity is reviewed. To our knowledge there are no other reported cases in which parathyroid scanning was used in diagnostic studies of parathyroid lipoadenoma. 15 references

  5. Reliability of patient-reported outcome instruments in US adults with hemophilia: the Pain, Functional Impairment and Quality of life (P-FiQ study

    Directory of Open Access Journals (Sweden)

    Kempton CL

    2017-09-01

    Full Text Available Christine L Kempton,1 Michael Wang,2 Michael Recht,3 Anne Neff,4 Amy D Shapiro,5 Amit Soni,6 Roshni Kulkarni,7 Tyler W Buckner,2 Katharine Batt,8 Neeraj N Iyer,9 David L Cooper9 1Departments of Pediatrics and Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA; 2Hemophilia and Thrombosis Center, University of Colorado School of Medicine, Aurora, CO, USA; 3The Hemophilia Center, Oregon Health & Science University, Portland, OR, USA; 4Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH, USA; 5Indiana Hemophilia & Thrombosis Center, Indianapolis, IN, USA; 6Center for Inherited Blood Disorders and CHOC Children’s Hospital/UC Irvine, Orange, CA, USA; 7MSU Center for Bleeding and Clotting Disorders, Michigan State University, East Lansing, MI, USA; 8Hematology and Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA; 9Clinical, Medical and Regulatory Affairs, Novo Nordisk Inc., Plainsboro, NJ, USA Background: Hemophilia is marked by frequent joint bleeding, resulting in pain and functional impairment.Objective: This study aimed to assess the reliability of five patient-reported outcome (PRO instruments in people with hemophilia (PWH in a non-bleeding state.Methods: Adult male PWH of any severity and inhibitor status, with a history of joint pain or bleeding, completed a pain history and five PRO instruments (EQ-5D-5L, Brief Pain Inventory v2 [BPI], International Physical Activity Questionnaire [IPAQ], Short Form 36 Health Survey v2 [SF-36v2], and Hemophilia Activities List [HAL] during their routine comprehensive care visit. Patients were approached to complete the PRO instruments again at the end of their visit while in a similar non-bleeding state. Concordance of individual questionnaire items and correlation between domain scores were assessed using intra-class correlation coefficient (ICC.Results: Participants completing the retest (n=164 had a median age of 33.9 years. Median time for

  6. Reporting Recommended Patch Density from Vehicle Panel Vibration Convergence Studies using both DAF and TBL Fits of the Spatial Correlation Function

    Science.gov (United States)

    Smith, Andrew M.; Davis, Robert Ben; LaVerde, Bruce T.; Jones, Douglas C.; Band, Jonathon L.

    2012-01-01

    Using the patch method to represent the continuous spatial correlation function of a phased pressure field over a structural surface is an approximation. The approximation approaches the continuous function as patches become smaller. Plotting comparisons of the approximation vs the continuous function may provide insight revealing: (1) For what patch size/density should the approximation be very good? (2) What the approximation looks like when it begins to break down? (3) What the approximation looks like when the patch size is grossly too large. Following these observations with a convergence study using one FEM may allow us to see the importance of patch density. We may develop insights that help us to predict sufficient patch density to provide adequate convergence for the intended purpose frequency range of interest

  7. FY 1993 annual report. Survey and study on establishment of databases for body functions; 1993 nendo shintai kino database no kochiku ni kansuru chosa kenkyu hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-03-01

    As part of the health/welfare-related information collection, analysis and information service project, establishment of the databases is surveyed and studied for human life technology and body functions of the aged in the aging society. The survey/study on establishment of the human life technology for the aged covers concept of human life technology, systems of the databases for human life technology, and techniques for the database systems. The case study on the human life technology databases for the aged takes up everyday life behaviors of the aged as the models, and analyzes human and life characteristics in everyday life, to clarify the human characteristic, human performance and human life technology design data to be stored in the databases. The validity of the method developed by this project is tested for their behaviors, such as bathing and outgoing. For establishment of the databases for body functions of the aged, literature surveys and interviews are conducted for the technological trends. (NEDO)

  8. A Density Functional Theory Study

    KAUST Repository

    Lim, XiaoZhi

    2011-12-11

    Complexes with pincer ligand moieties have garnered much attention in the past few decades. They have been shown to be highly active catalysts in several known transition metal-catalyzed organic reactions as well as some unprecedented organic transformations. At the same time, the use of computational organometallic chemistry to aid in the understanding of the mechanisms in organometallic catalysis for the development of improved catalysts is on the rise. While it was common in earlier studies to reduce computational cost by truncating donor group substituents on complexes such as tertbutyl or isopropyl groups to hydrogen or methyl groups, recent advancements in the processing capabilities of computer clusters and codes have streamlined the time required for calculations. As the full modeling of complexes become increasingly popular, a commonly overlooked aspect, especially in the case of complexes bearing isopropyl substituents, is the conformational analysis of complexes. Isopropyl groups generate a different conformer with each 120 ° rotation (rotamer), and it has been found that each rotamer typically resides in its own potential energy well in density functional theory studies. As a result, it can be challenging to select the most appropriate structure for a theoretical study, as the adjustment of isopropyl substituents from a higher-energy rotamer to the lowest-energy rotamer usually does not occur during structure optimization. In this report, the influence of the arrangement of isopropyl substituents in pincer complexes on calculated complex structure energies as well as a case study on the mechanism of the isomerization of an iPrPCP-Fe complex is covered. It was found that as many as 324 rotamers can be generated for a single complex, as in the case of an iPrPCP-Ni formato complex, with the energy difference between the global minimum and the highest local minimum being as large as 16.5 kcalmol-1. In the isomerization of a iPrPCP-Fe complex, it was found

  9. Interim storage study report

    Energy Technology Data Exchange (ETDEWEB)

    Rawlins, J.K.

    1998-02-01

    High-level radioactive waste (HLW) stored at the Idaho Chemical Processing Plant (ICPP) in the form of calcine and liquid and liquid sodium-bearing waste (SBW) will be processed to provide a stable waste form and prepare the waste to be transported to a permanent repository. Because a permanent repository will not be available when the waste is processed, the waste must be stored at ICPP in an Interim Storage Facility (ISF). This report documents consideration of an ISF for each of the waste processing options under consideration.

  10. Associations and predictions of readmission or death in acutely admitted older medical patients using self-reported frailty and functional measures. A Danish cohort study

    DEFF Research Database (Denmark)

    Andreasen, Jane; Aadahl, Mette; Sørensen, Erik Elgaard

    2018-01-01

    OBJECTIVE: To assess whether frailty in acutely admitted older medical patients, assessed by a self-report questionnaire and evaluation of functional level at discharge, was associated with readmission or death within 6 months after discharge. A second objective was to assess the predictive...... measured. Associations were assessed using Cox regression with first unplanned readmission or death (all-causes) as the outcome. Prediction models including the three exposure variables and known risk factors were modelled using logistic regression and C-statistics. RESULTS: Of 1328 included patients, 50......% were readmitted or died within 6 months. When adjusted for gender and age, there was an 88% higher risk of readmission or death if the TFI scores were 8-13 points compared to 0-1 points (HR 1.88, CI 1.38;2.58). Likewise, higher TUG and lower GS scores were associated with higher risk of readmission...

  11. Heat transfer studies. Quarterly report

    International Nuclear Information System (INIS)

    Boehm, R.; Chen, Y.; Ma, L.; Izzelldin, A.

    1994-01-01

    The engineers in the modeling group in performance assessment at US DOE YMSCO have recently indicated an important concern about the results of the previous thermal-hydrologic calculations. This concern is that these calculations may incorporate some deficiencies in the current understanding of physical processes occurring in the drift at elevated temperatures and subresidual liquid saturations. They have found that the numerical modelers have used a modified capillary pressure function to fix arbitrarily the maximum capillary pressure for subresidual saturations. In addition, code developers have used certain numerical procedures to interpolate the liquid saturations ranging from 0 to residual saturation in numerical codes to avert numerical convergence problems. This kind of assumption may not represent the real conditions at the near-field of high-level radioactive nuclear waste repository due to a high thermal load from the waste packages. This report describes a study of the effects of the elevated temperature on the saturation capillary pressure

  12. Cannabis Use Is Associated With Increased Psychotic Symptoms and Poorer Psychosocial Functioning in First-Episode Psychosis: A Report From the UK National EDEN Study.

    Science.gov (United States)

    Seddon, Jennifer L; Birchwood, Max; Copello, Alex; Everard, Linda; Jones, Peter B; Fowler, David; Amos, Tim; Freemantle, Nick; Sharma, Vimal; Marshall, Max; Singh, Swaran P

    2016-05-01

    The use of cannabis during the early stage of psychosis has been linked with increased psychotic symptoms. This study aimed to examine the use of cannabis in the 12 months following a first-episode of psychosis (FEP) and the link with symptomatic course and outcome over 1 year post psychosis onset. One thousand twenty-seven FEP patients were recruited upon inception to specialized early intervention services (EIS) for psychosis in the United Kingdom. Participants completed assessments at baseline, 6 and 12 months. The results indicate that the use of cannabis was significantly associated with increased severity of psychotic symptoms, mania, depression and poorer psychosocial functioning. Continued use of cannabis following the FEP was associated with poorer outcome at 1 year for Positive and Negative Syndrome Scale total score, negative psychotic symptoms, depression and psychosocial functioning, an effect not explained by age, gender, duration of untreated psychosis, age of psychosis onset, ethnicity or other substance use. This is the largest cohort study of FEP patients receiving care within EIS. Cannabis use, particularly "continued use," was associated with poorer symptomatic and functional outcome during the FEP. The results highlight the need for effective and early intervention for cannabis use in FEP. © The Author 2015. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  13. Radiation effect of radioiodide therapy on the hypophyseal and hypothalamic feedback control centers for thyroid function studied by dry-mount autoradiography. Final technical report

    International Nuclear Information System (INIS)

    Stumpf, W.E.

    1972-01-01

    Results are reported from studies in rats on the effects of β radiation from therapeutic doses of 131 I on the physiology of the pituitary gland and on brain structures considered thyroid hormone control areas. Iodine-125-labeled triiodothyronine and thyroxine and autoradiographic techniques were used to determine the cellular and subcellular localization of thyroid hormones in the brain tissues of untreated and thyroidectomized animals. The results suggest that thyroid hormones act on all neurons throughout the mature brain. (U.S.)

  14. Radionuclide renal dynamic and function study

    International Nuclear Information System (INIS)

    Guan Liang

    1991-01-01

    The radionuclide dynamic and function study, glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were reported in 14 cases of renal and ureteral calculi patients before and after extracorporeal shock wave lithotripsy (ESWL). In 12 cases with normal renal blood flow, within 3 months after ESWL, the GFR of shock and non-shock side decreased with different extent, while the individual ERPF had little change. In 5 cases followed up 1 year after ESWL, the individual GFR and ERPF were normal. In 2 cases of severe renal function insufficiency, there was no improvement in renal function in shock side, after 5 months and 1 year, the renal function was still at low level. Thereby it is considered that ESWL is not suitable for the renal calculi patients with severe renal function insufficiency

  15. Postural balance, its sensory-motor correlates and self-reported functional ability in 75-year-old men and women: A cross-national comparative study

    DEFF Research Database (Denmark)

    Schroll, Marianne; Pertti, Era; Avlund, Kirsten

    1999-01-01

    Social medicine, postural balance, functional ability, activities of daily living, physical activity, ageing......Social medicine, postural balance, functional ability, activities of daily living, physical activity, ageing...

  16. Near-infrared spectroscopic study and the Wada test for presurgical evaluation of expressive and receptive language functions in glioma patients: with a case report of dissociated language functions.

    Science.gov (United States)

    Sato, Yosuke; Uzuka, Takeo; Aoki, Hiroshi; Natsumeda, Manabu; Oishi, Makoto; Fukuda, Masafumi; Fujii, Yukihiko

    2012-02-29

    Near-infrared spectroscopy (NIRS) has proven to be useful for the evaluation of language lateralization in healthy subjects, infants, and epileptic patients. This study for the first time investigated the expressive and receptive language functions separately, using NIRS in presurgical glioma patients. We also describe a special case with dissociated pattern of language functions. Ten glioma patients were examined. Using NIRS, the hemodynamic changes during a verb generation task or story listening task were measured in the cerebral hemisphere on either side covering the language areas. Following the NIRS study, the Wada test was performed in all the patients. The NIRS study revealed increases of oxyhemoglobin and decreases of deoxyhemoglobin in the language areas elicited by both tasks. In 9 patients, who were all right-handed, the expressive and receptive language functions were lateralized to the left hemisphere. The results of the NIRS study were completely consistent with those of the Wada test. In the remaining 1 patient with a right sided insular glioma, who was right-handed, the NIRS study revealed stronger activation of the right inferior frontal region during the verb generation task, and stronger activation of the left superior temporal region during the story listening task. This dissociated language function was validated by the Wada test and the postoperative neurological course. These results demonstrate that a NIRS study using our technique is extremely valuable for preoperative assessment of the language functions and exemplifies how a preoperative NIRS study can allow detection of unforeseen language lateralization. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  17. Asian Consensus Report on Functional Dyspepsia

    Science.gov (United States)

    Miwa, Hiroto; Ghoshal, Uday C; Gonlachanvit, Sutep; Gwee, Kok-Ann; Ang, Tiing-Leong; Chang, Full-Young; Fock, Kwong Ming; Hongo, Michio; Hou, Xiaohua; Kachintorn, Udom; Ke, Meiyun; Lai, Kwok-Hung; Lee, Kwang Jae; Lu, Ching-Liang; Mahadeva, Sanjiv; Miura, Soichiro; Park, Hyojin; Rhee, Poong-Lyul; Sugano, Kentaro; Vilaichone, Ratha-korn; Wong, Benjamin CY

    2012-01-01

    Background/Aims Environmental factors such as food, lifestyle and prevalence of Helicobacter pylori infection are widely different in Asian countries compared to the West, and physiological functions and genetic factors of Asians may also be different from those of Westerners. Establishing an Asian consensus for functional dyspepsia is crucial in order to attract attention to such data from Asian countries, to articulate the experience and views of Asian experts, and to provide a relevant guide on management of functional dyspepsia for primary care physicians working in Asia. Methods Consensus team members were selected from Asian experts and consensus development was carried out using a modified Delphi method. Consensus teams collected published papers on functional dyspepsia especially from Asia and developed candidate consensus statements based on the generated clinical questions. At the first face-to-face meeting, each statement was reviewed and e-mail voting was done twice. At the second face-to-face meeting, final voting on each statement was done using keypad voting system. A grade of evidence and a strength of recommendation were applied to each statement according to the method of the GRADE Working Group. Results Twenty-nine consensus statements were finalized, including 7 for definition and diagnosis, 5 for epidemiology, 9 for pathophysiology and 8 for management. Algorithms for diagnosis and management of functional dyspepsia were added. Conclusions This consensus developed by Asian experts shows distinctive features of functional dyspepsia in Asia and will provide a guide to the diagnosis and management of functional dyspepsia for Asian primary care physicians. PMID:22523724

  18. MRS [monitored retrievable storage] systems study Task G report: The role and functions of surface storage of radioactive material in the federal waste management system

    International Nuclear Information System (INIS)

    Wood, T.W.; Short, S.M.; Woodruff, M.G.; Altenhofen, M.K.; MacKay, C.A.

    1989-04-01

    This is one of nine studies undertaken by contractors to the US Department of Energy (DOE), Office of Civilian Radioactive Waste Management (OCRWM), to provide a technical basis for re-evaluating the role of a monitored retrievable storage (MRS) facility. The study investigates the functions that could be performed by surface storage of radioactive material within the federal radioactive waste management system, including enabling acceptance of spent fuel from utility owners, scheduling of waste-preparation processes within the system, enhancement of system operating reliability, and conditioning the thermal (decay heat) characteristics of spent fuel emplaced in a repository. The analysis focuses particularly on the effects of storage capacity and DOE acceptance schedule on power reactors. Figures of merit developed include the storage capacity [in metric tons of uranium (MTU)] required to be added beyond currently estimated maximum spent fuel storage capacities and its associated cost, and the number of years that spent fuel pools would remain open after last discharge (in pool-years) and the cost of this period of operation. 27 refs., 36 figs., 18 tabs

  19. Radionuclide study of thyroid function in pediatrics, using sup(99m)Tc, 123I or 131I: 150 case-reports

    International Nuclear Information System (INIS)

    Guillet, J.; Basse-Cathalinat, B.; Soubiran, G.; Blanquet, P.; Guillet, G.

    1981-01-01

    THe best radioisotope for in vivo thyroid investigations is the one which provides the highest quality scintigrams with the least radiation exposure. The choice of 131 I, 123 I or sup(99m)Tc in 150 children is discussed. Cases included 25 dysgenesis, 4 goiters with hypothyroidism, 56 goiters without thyroid dysfunction, 3 thyroiditis, and 11 cold nodules. When thyroid scanning is performed with 131 I, the gland's radiation exposure is high. 123 I is preferable since a fairly high activity can be obtained without delivering an excessive radiation dose. (approximately 2 rad to the thyroid for 50 microCi/m 2 ). sup(99m)Tc which is readily available is not a true iodine analog. It does not give a true picture of iodine metabolism. 123 I was generally used in cases of hypothyroidism, goiter (whenever a defect in thyroid hormone synthesis was suspected) and hyperthyroidism. sup(99m)Tc was generally used in other cases. The low radiation doses delivered by these radioisotopes allows study of thyroid function in the neonate [fr

  20. Radionuclide study of thyroid function in pediatrics, using sup(99m)Tc, /sup 123/I or /sup 131/I: 150 case-reports

    Energy Technology Data Exchange (ETDEWEB)

    Guillet, J.; Basse-Cathalinat, B.; Soubiran, G.; Blanquet, P. (Hopital Pellegrin, 33 - Bordeaux (France)); Guillet, G. (Johns Hopkins Medical Institutions, Baltimore, MD (USA). Div. of Nuclear Medicine)

    1981-11-01

    THe best radioisotope for in vivo thyroid investigations is the one which provides the highest quality scintigrams with the least radiation exposure. The choice of /sup 131/I, /sup 123/I or sup(99m)Tc in 150 children is discussed. Cases included 25 dysgenesis, 4 goiters with hypothyroidism, 56 goiters without thyroid dysfunction, 3 thyroiditis, and 11 cold nodules. When thyroid scanning is performed with /sup 131/I, the gland's radiation exposure is high. /sup 123/I is preferable since a fairly high activity can be obtained without delivering an excessive radiation dose. (approximately 2 rad to the thyroid for 50 microCi/m/sup 2/). sup(99m)Tc which is readily available is not a true iodine analog. It does not give a true picture of iodine metabolism. /sup 123/I was generally used in cases of hypothyroidism, goiter (whenever a defect in thyroid hormone synthesis was suspected) and hyperthyroidism. sup(99m)Tc was generally used in other cases. The low radiation doses delivered by these radioisotopes allows study of thyroid function in the neonate.

  1. Defining the Interactions of Cellobiohydrolase with Substrate through Structure Function Studies: Cooperative Research and Development Final Report, CRADA Number CRD-10-409

    Energy Technology Data Exchange (ETDEWEB)

    Beckham, G. T.; Himmel, M. E.

    2013-07-01

    NREL researchers will use their expertise and skilled resources in numerical computational modeling to generate structure-function relationships for improved cellulase variant enzymes to support the development of cellulases with improved performance in biomass conversion.

  2. Neuropsychological assessment of language functions during functional magnetic resonance imaging: development of new tasks. Preliminary report.

    Science.gov (United States)

    Fersten, Ewa; Jakuciński, Maciej; Kuliński, Radosław; Koziara, Henryk; Mroziak, Barbara; Nauman, Paweł

    2011-01-01

    Due to the complex and extended cerebral organization of language functions, the brain regions crucial for speech and language, i.e. eloquent areas, have to be affected by neurooncological surgery. One of the techniques that may be helpful in pre-operative planning of the extent of tumour removal and estimating possible complications seems to be functional magnetic resonance imaging (fMRI). The aim of the study was to develop valid procedures for neuropsychological assessment of various language functions visualisable by fMRI in healthy individuals. In this fMRI study, 10 healthy (with no CNS pathology), right-handed volunteers aged 25-35 were examined using four tasks designed to measure different language functions, and one for short-term memory assessment. A 1.5-T MRI scanner performing ultrafast functional (EPI) sequences with 4-mm slice thickness and 1-mm interslice gap was used to detect the BOLD response to stimuli present-ed in a block design (30-second alternating blocks of activity and rest). The analyses used the SPM software running in a MATLAB environment, and the obtained data were interpreted by means of colour-coded maps superimposed on structural brain scans. For each of the tasks developed for particular language functions, a different area of increased neuronal activity was found. The differential localization of function-related neuronal activity seems interesting and the research worth continuing, since verbal communication failure may result from impairment of any of various language functions, and studies reported in the literature seem to focus on verbal expression only.

  3. Brief Report: Examining Driving Behavior in Young Adults with High Functioning Autism Spectrum Disorders--A Pilot Study Using a Driving Simulation Paradigm

    Science.gov (United States)

    Reimer, Bryan; Fried, Ronna; Mehler, Bruce; Joshi, Gagan; Bolfek, Anela; Godfrey, Kathryn M.; Zhao, Nan; Goldin, Rachel; Biederman, Joseph

    2013-01-01

    Although it is speculated that impairments associated with autism spectrum disorder (ASD) will adversely affect driving performance, little is known about the actual extent and nature of the presumed deficits. Ten males (18-24 years of age) with a diagnosis of high functioning autism and 10 age matched community controls were recruited for a…

  4. Study of quark structure functions

    International Nuclear Information System (INIS)

    Dao, F.T.; Flaminio, E.; Lai, K.; Metcalf, M.; Wang, L.

    1977-01-01

    The quark structure functions of the proton are determined through a combined analysis of the reactions pN → ll-barX and eN → eX. The valence-quark structure function of the pion is also given by analyzing the πN → μμ-barX data measured by the Branson et al

  5. Self-Reported Decline in Everyday Function, Cognitive Symptoms, and Cognitive Function in People With HIV.

    Science.gov (United States)

    Laverick, Rosanna; Haddow, Lewis; Daskalopoulou, Marina; Lampe, Fiona; Gilson, Richard; Speakman, Andrew; Antinori, Andrea; Bruun, Tina; Vassilenko, Anna; Collins, Simon; Rodger, Alison

    2017-11-01

    We determined factors associated with self-reported decline in activities of daily living (ADLs) and symptoms of cognitive impairment in HIV positive adults in 5 European clinics. HIV+ adults underwent computerized and pen-and-paper neuropsychological tests and questionnaires of cognitive symptoms and ADLs. We considered cognitive function in 5 domains, psychosocial factors, and clinical parameters as potentially associated with symptoms. Separate regression analyses were used to determine factors associated with a decline in ADL (defined as self-reported decline affecting ≥2 ADLs and attributed to cognitive difficulties) and self-reported frequency of symptoms of cognitive impairment. We also estimated the diagnostic accuracy of both questionnaires as tests for cognitive impairment. Four hundred forty-eight patients completed the assessments [mean age 45.8 years, 84% male, 87% white, median CD4 count 550 cells/mm, median time since HIV diagnosis 9.9 years, 81% virologically suppressed (HIV-1 plasma RNA symptoms of cognitive impairment were both associated with worse performance on some cognitive tests. There were also strong associations with financial difficulties, depressive and anxiety symptoms, unemployment, and longer time since HIV diagnosis. Both questionnaires performed poorly as diagnostic tests for cognitive impairment. Patients' own assessments of everyday function and symptoms were associated with objectively measured cognitive function. However, there were strong associations with other psychosocial issues including mood and anxiety disorders and socioeconomic hardship. This should be considered when assessing HIV-associated cognitive impairment in clinical care or research studies.

  6. Human performance in nondestructive inspections and functional tests: Final report

    International Nuclear Information System (INIS)

    Harris, D.H.

    1988-10-01

    Human performance plays a vital role in the inspections and tests conducted to assure the physical integrity of nuclear power plants. Even when technically-sophisticated equipment is employed, the outcome is highly dependent on human control actions, calibrations, observations, analyses, and interpretations. The principal consequences of inadequate performance are missed or falsely-reported defects. However, the cost-avoidance that stems from addressing potential risks promptly, and the increasing costs likely with aging plants, emphasize that timeliness and efficiency are important inspection-performance considerations also. Human performance issues were studied in a sample of inspections and tests regularly conducted in nuclear power plants. These tasks, selected by an industry advisory panel, were: eddy-current inspection of steam-generator tubes; ultrasonic inspection of pipe welds; inservice testing of pumps and valves; and functional testing of shock suppressors. Information was obtained for the study from industry and plant procedural documents; training materials; research reports and related documents; interviews with training specialists, inspectors, supervisory personnel, and equipment designers; and first-hand observations of task performance. Eleven recommendations are developed for improving human performance on nondestructive inspections and functional tests. Two recommendations were for the more-effective application of existing knowledge; nine recommendations were for research projects that should be undertaken to assure continuing improvements in human performance on these tasks. 25 refs., 9 figs., 1 tab

  7. Positron emission tomography in brain function study

    International Nuclear Information System (INIS)

    Wu Hua

    2006-01-01

    Little has been recognized about the advanced brain function. Recent years several new techniques such as event-related potentials, megnetoencephalography, functional magnetic resonance imaging and positron emission tomography (PET) have been used in the study of brain function. The methodology, application study in normal people and clinical patients of PET in brain function are reviewed. (authors)

  8. Effectiveness of a Tai Chi intervention for improving functional fitness and general health among ethnically diverse older adults with self-reported arthritis living in low-income neighborhoods: a cohort study.

    Science.gov (United States)

    Dogra, Shilpa; Shah, Suhayb; Patel, Meghavi; Tamim, Hala

    2015-01-01

    Tai Chi (TC) is a form of low to moderate physical activity that has been shown to significantly impact health and functional fitness among older adults; the impact of TC on the health and functional fitness of older adults with arthritis is not well understood. The purpose of this study was to assess the effectiveness of a 16-week TC intervention for improving functional fitness and self-reported general health among older adults with arthritis who were born outside Canada and were residing in low-income neighborhoods. A 16-week intervention was conducted among older adults residing in 1 of 2 specified low-income neighborhoods in Canada. The analysis was limited to those who self-reported having arthritis (n = 102). Participants were encouraged to attend 2 moderate-intensity TC sessions per week for a total of 120 minutes. Functional fitness and health were assessed at baseline and at 16 weeks. Average attendance was 1.1 sessions per week. Functional fitness assessment results indicated that right-hand grip strength (25.6 ± 8.2 to 26.7 ± 7.8 kg), left-hand grip strength (24.9 ± 7.3 to 26.8 ± 7.1 kg), 30-second arm curl (15.6 ± 5.0 to 18.6 ± 5.7 repetitions/30 s), Timed Up-and-Go (7.4 ± 2.6 to 6.9 ± 2.6 s), and 30-second chair stand (12.0 ± 3.9 to 15.4 ± 5.8 s) improved significantly (P health (61.5 ± 20.9 to 66.0 ± 20.4; P = 0.03), vitality (61.5 ± 18.9 to 67.5 ± 20.2; P = 0.008), and mental health (74.3 ± 16.5 to 78.5 ± 17.7; P = 0.04) also improved significantly over the intervention period. Improvements in physical health and physical function scores were clinically meaningful. Participating in TC for 16 weeks led to significant improvements in functional fitness and components of physical and mental health among older adults with self-reported arthritis. Tai Chi seems to be a valuable mode of physical activity for this population.

  9. Association between report of insomnia and daytime functioning.

    Science.gov (United States)

    Ustinov, Yuriy; Lichstein, Kenneth L; Wal, Gregory S Vander; Taylor, Daniel J; Riedel, Brant W; Bush, Andrew J

    2010-01-01

    The relationship between reports of insomnia and daytime functioning was investigated using hierarchical regression. The presence or absence of a report of insomnia was the predictor of primary interest. A number of covariates were included in the model: demographic variables, health variables, and quantitative sleep parameters. Data were collected from a community sample in the Memphis, Tennessee area. Data from 734 volunteers, ranging in age from 20 to 96years were analyzed. The sample included 235 individuals who reported having chronic insomnia and 499 individuals who reported no sleep problems. Participants completed a 2-week sleep diary, a battery of daytime functioning questionnaires, and a medical disorders checklist. Demographic information was also collected. The daytime functioning assessment included the Beck Depression Inventory, the State-Trait Anxiety Inventory, the Epworth Sleepiness Scale, the Insomnia Impact Scale, and the Fatigue Severity Scale. The hierarchical regression model included four sets. The first three sets consisted of 18 variables capturing demographic, health, and sleep diary parameters. The fourth set included a single dichotomous variable representing the presence or absence of a report of insomnia. Reports of insomnia were a significant predictor of all five daytime functioning measures, which is consistent with previous research. We also showed that reports of insomnia were able to uniquely explain a significant amount of variability in self-reported daytime functioning after controlling for demographics, health, and sleep diary variables. The pattern of individual variables that reached significance in the first three sets varied depending on which daytime functioning measure was predicted, however, age, the presence of pain, the presence of mental health problems, SOL, and WASO were the most commonly significant predictors of poor daytime functioning from these sets across measures. Individuals' perceptions of their sleep are

  10. Test Review: Behavior Rating Inventory of Executive Function--Self-Report Version

    Science.gov (United States)

    Walker, Justin M.; D'Amato, Rik Carl

    2006-01-01

    The Behavior Rating Inventory of Executive Function-Self-Report version (BRIEF-SR) is the first self-report measure of executive functioning for adolescents. With the Individuals With Disabilities Education Improvement Act authorization, there is a greater need for appropriate assessment of severely impaired children. Recent studies have…

  11. Final report on case studies

    DEFF Research Database (Denmark)

    Ljungberg, Daniel; McKelvey, Maureen; Lassen, Astrid Heidemann

    2012-01-01

    Case study as a research design means investigating a single or multiple instance(s) or setting(s) (i.e. a case) and its entire context to explain a phenomenon and its processes. This is achieved through detailed understanding, usually comprised of multiple sources of information. In this way, case...... studies attempt to provide as a complete an understanding of a (complex) phenomenon as possible. Within the AEGIS project, survey and case study research are complementary. They are complementary in the sense that the former can provide more generalizable evidence on a phenomenon in terms of cross......-sectional data, while the latter can provide more in-depth (qualitative) understanding on specific issues. In systematically examining the case studies, however, this report goes beyond a typical single case study. Here we provide a synthesis of 86 case studies. Multiple case studies, following similar focus...

  12. Fiscal 1994 survey report. Part 2. Study on soil environment remediation system using ecological information and functions; 1994 nendo seitaikei joho to seitaikei kino ni yoru dojo kankyo fukugen system no chosa hokokusho. 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-01

    A survey is conducted of the feasibility of soil environment remediation through detecting contamination of soil and changes in ecosystems caused by industrial activities, with attention paid to biological antagonists. In this fiscal year, based on the results of surveys conducted in the past, studies are continued mainly on hypersensitive biosensing technology using ecosystem functions, remote sensing technology to monitor the terrestrial vegetation and soil environment over wide areas, and soil environment remediation technology using biological antagonists and vegetation. In consideration of Europe's long experience in this field, seven organizations known for their accomplishments are visited, where interviews are held. There is a close relationship between soil environments and ecosystems, and ecosystems are provided not only with information on changes in soil environments but also with functions to remedy soil environments by minimizing secondary contamination. To put such information and functions to practical use, element technologies are indispensable, including hypersensitive soil environment biosensors and environmental remediation by identification and isolation of biological information carrying substances and by vegetation. Proposed in this report is a project for soil remediation by use of biological information and functions and for elucidation of biological antagonists. (NEDO)

  13. Fiscal 1994 survey report. Part 2. Study on soil environment remediation system using ecological information and functions; 1994 nendo seitaikei joho to seitaikei kino ni yoru dojo kankyo fukugen system no chosa hokokusho. 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-01

    A survey is conducted of the feasibility of soil environment remediation through detecting contamination of soil and changes in ecosystems caused by industrial activities, with attention paid to biological antagonists. In this fiscal year, based on the results of surveys conducted in the past, studies are continued mainly on hypersensitive biosensing technology using ecosystem functions, remote sensing technology to monitor the terrestrial vegetation and soil environment over wide areas, and soil environment remediation technology using biological antagonists and vegetation. In consideration of Europe's long experience in this field, seven organizations known for their accomplishments are visited, where interviews are held. There is a close relationship between soil environments and ecosystems, and ecosystems are provided not only with information on changes in soil environments but also with functions to remedy soil environments by minimizing secondary contamination. To put such information and functions to practical use, element technologies are indispensable, including hypersensitive soil environment biosensors and environmental remediation by identification and isolation of biological information carrying substances and by vegetation. Proposed in this report is a project for soil remediation by use of biological information and functions and for elucidation of biological antagonists. (NEDO)

  14. Cognitive, behaviour, and academic functioning in adolescent and young adult survivors of childhood acute lymphoblastic leukaemia: a report from the Childhood Cancer Survivor Study.

    Science.gov (United States)

    Jacola, Lisa M; Edelstein, Kim; Liu, Wei; Pui, Ching-Hon; Hayashi, Robert; Kadan-Lottick, Nina S; Srivastava, Deokumar; Henderson, Tara; Leisenring, Wendy; Robison, Leslie L; Armstrong, Gregory T; Krull, Kevin R

    2016-10-01

    Survivors of childhood acute lymphoblastic leukaemia (ALL) are at risk for neurocognitive deficits that affect development in adolescence and young adulthood, and influence educational attainment and future independence. We examined a large and diverse cohort of survivors to identify risk predictors and modifiers of these outcomes. In this cohort study, cognitive and behaviour symptoms were assessed via a standardised parent questionnaire for 1560 adolescent survivors of ALL diagnosed between 1970 and 1999. Clinically significant symptoms (≥90th percentile) and learning problems were compared between survivors and a sibling cohort. Multivariable regression models were used to examine associations with demographic and treatment characteristics. Models were adjusted for inverse probability of sampling weights to reflect undersampling of ALL survivors in the expansion cohort. In a subset of survivors with longitudinal data (n=925), we examined associations between adolescent symptoms or problems and adult educational attainment. Compared with siblings, survivors treated with chemotherapy only were more likely to demonstrate headstrong behaviour (155 [19%] of 752 survivors vs 88 [14%] of 610 siblings, p=0·010), inattention-hyperactivity (15 [19%] vs 86 [14%], p4·3 g/m 2 ) conferred increased risk of inattention-hyperactivity (relative risk [RR] 1·53, 95% CI 1·13-2·08). Adolescent survivors with cognitive or behaviour problems and those with learning problems were less likely to graduate from college as young adults than adolescent survivors without cognitive or behaviour problems. Although modern therapy for childhood ALL has eliminated the use of cranial radiation therapy, adolescent survivors treated with chemotherapy only remain at increased risk for cognitive, behaviour, and academic problems that adversely affect adult education outcomes. National Cancer Institute, American Lebanese-Syrian Associated Charities. Copyright © 2016 Elsevier Ltd. All rights

  15. Self- and surrogate-reported communication functioning in aphasia.

    Science.gov (United States)

    Doyle, Patrick J; Hula, William D; Austermann Hula, Shannon N; Stone, Clement A; Wambaugh, Julie L; Ross, Katherine B; Schumacher, James G

    2013-06-01

    To evaluate the dimensionality and measurement invariance of the aphasia communication outcome measure (ACOM), a self- and surrogate-reported measure of communicative functioning in aphasia. Responses to a large pool of items describing communication activities were collected from 133 community-dwelling persons with aphasia of ≥ 1 month post-onset and their associated surrogate respondents. These responses were evaluated using confirmatory and exploratory factor analysis. Chi-square difference tests of nested factor models were used to evaluate patient-surrogate measurement invariance and the equality of factor score means and variances. Association and agreement between self- and surrogate reports were examined using correlation and scatterplots of pairwise patient-surrogate differences. Three single-factor scales (Talking, Comprehension, and Writing) approximating patient-surrogate measurement invariance were identified. The variance of patient-reported scores on the Talking and Writing scales was higher than surrogate-reported variances on these scales. Correlations between self- and surrogate reports were moderate-to-strong, but there were significant disagreements in a substantial number of individual cases. Despite minimal bias and relatively strong association, surrogate reports of communicative functioning in aphasia are not reliable substitutes for self-reports by persons with aphasia. Furthermore, although measurement invariance is necessary for direct comparison of self- and surrogate reports, the costs of obtaining invariance in terms of scale reliability and content validity may be substantial. Development of non-invariant self- and surrogate report scales may be preferable for some applications.

  16. Paramagnetic pharmaceuticals for functional studies

    International Nuclear Information System (INIS)

    Hall, L.D.; Hogan, P.G.

    1987-01-01

    It has been suggested that limitations of the Magnetic Resonance Imaging (MRI) method may be minimised by the use of ''image contrast'' agents. These are exogenous chemicals administered to the patient which, by influencing the magnetic resonance properties of the water in the region of the pathology, serve to heighten the contrast between that tissue and its surroundings. At present the most widely used agent is gadolinium-DTPA (Gd-DTPA). This appears to have many desirable features and its development provides a textbook example for the early stages of any future development. All compounds used so far can be subdivided into one of the following categories: Paramagnetic metal species; Ferromagnetic metal species; Stable free radicals; Oxygen carriers; Susceptibility agents; and Density substitution agents. The authors summarise briefly these chemical substances and their reported uses

  17. MULTIPLE PERSONALITY: CASE REPORT STUDY

    Directory of Open Access Journals (Sweden)

    Miloš Židanik

    2004-07-01

    Full Text Available Background. Multiple personality disorder is characterised by splited individual ego-states and splited professional community arguing whether this disorder actually exists or not.Methods. In this case report study a supportive psychodynamic psychotherapy of a patient with multiple personality disorder is presented, that lasted for 4.5 years and resulted in ego-reintegration.Conclusions. The spliting between different ego-states is powered by unneutralised aggression with the possibility of hetero- and autoaggressive behaviour. Therefore the patient in the analytically oriented psychotherapeutic process is at high risk and a safe therapeutic (e. g. in-patient setting has to be provided.

  18. Repository design sensitivity study: Engineering study report

    International Nuclear Information System (INIS)

    1987-01-01

    A preliminary sensitivity study of the salt repository design has been performed to identify critical site and design parameters to help guide future site characterization and design optimization activities. The study considered the SCP-conceptual design at the Deaf Smith County site in Texas with the horizontal waste package emplacement mode as the base case. Relative to this base case, parameter variations were compared. Limited studies were performed which considered the vertical emplacement mode geometry. The report presents the reference data base and design parameters on which the study was based (including the range of parameters that might be expected). Detailed descriptions of the numerical modeling methods and assumptions are included for the thermal, thermomechanical and hydrogeological analyses. The impacts of parameter variations on the sensitivity of the rock mass response are discussed. Recommendations are provided to help guide site characterization activities and advanced conceptual design optimization activities. 47 refs., 119 refs., 22 tabs

  19. Amplitude modulation of atomic wave functions. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-11-01

    The major theoretical advance has been to show that one can modulate Rydberg wave functions using either of two methods: (1) the amplitude modulation technique which depends on autoionization to deplete part of the wave function, or (2) a phase modulation method, which uses a change in the core potential to create a localized phase shift in the wave function. Essentially, these two methods can both be seen as using the core potential to change the Rydberg wave function, using the imaginary part of the potential to do amplitude modulation, or using the real part of the potential to do phase modulation. This work will be published as the authors acquire experimental results which show the differences between the two methods. One of the results of this theoretical study is that the initial proposal to study Barium 6snd states had a significant flaw. Neither the autoionization time, nor the quantum defect shifts are very large in these cases. This means that the modulation is relatively small. This shows itself primarily in the difficulty of seeing significant population redistribution into different 6snd states. The authors intend to correct this in the next funding cycle either: (a) by using the more quickly decaying Ba 6pnf states to modulate 6snd states, or (b) by using Sr 5 snd states, as outlined in this report. Their first, low power experiments are complete. These experiments have used two pulses to do a temporal version of the Ramsey separated oscillatory fields excitation. The two pulses are generated by passing the single pulse through a Michelson-Morley interferometer, which is computer controlled to sweep one arm through 2.5 {micro}m in steps of 10 nm. The second pulse`s excitation interferes with that of the first pulse, and so the total excitation has a sinusoidal variation (with a time period equal to the optical period) on top of a constant background. The amplitude of the total variation should decay at half of the rate decay rate of the autoionizing

  20. Self-Reported quality of life in adults with attention-deficit/hyperactivity disorder and executive function impairment treated with lisdexamfetamine dimesylate: a randomized, double-blind, multicenter, placebo-controlled, parallel-group study.

    Science.gov (United States)

    Adler, Lenard A; Dirks, Bryan; Deas, Patrick; Raychaudhuri, Aparna; Dauphin, Matthew; Saylor, Keith; Weisler, Richard

    2013-10-09

    This study examined the effects of lisdexamfetamine dimesylate (LDX) on quality of life (QOL) in adults with attention-deficit/hyperactivity disorder (ADHD) and clinically significant executive function deficits (EFD). This report highlights QOL findings from a 10-week randomized placebo-controlled trial of LDX (30-70 mg/d) in adults (18-55 years) with ADHD and EFD (Behavior Rating Inventory of EF-Adult, Global Executive Composite [BRIEF-A GEC] ≥65). The primary efficacy measure was the self-reported BRIEF-A; a key secondary measure was self-reported QOL on the Adult ADHD Impact Module (AIM-A). The clinician-completed ADHD Rating Scale version IV (ADHD-RS-IV) with adult prompts and Clinical Global Impressions-Severity (CGI-S) were also employed. The Adult ADHD QoL (AAQoL) was added while the study was in progress. A post hoc analysis examined the subgroup having evaluable results from both AIM-A and AAQoL. Of 161 randomized (placebo, 81; LDX, 80), 159 were included in the safety population. LDX improved AIM-A multi-item domain scores versus placebo; LS mean difference for Performance and Daily Functioning was 21.6 (ES, 0.93, PPsychological Health was 12.1; Life Outlook was 12.5; and Relationships was 7.3. In a post hoc analysis of participants with both AIM-A and AAQoL scores, AIM-A multi-item subgroup analysis scores numerically improved with LDX, with smaller difference for Impact of Symptoms: Daily Interference. The safety profile of LDX was consistent with amphetamine use in previous studies. Overall, adults with ADHD/EFD exhibited self-reported improvement on QOL, using the AIM-A and AAQoL scales in line with medium/large ES; these improvements were paralleled by improvements in EF and ADHD symptoms. The safety profile of LDX was similar to previous studies. ClinicalTrials.gov, NCT01101022.

  1. Report of fission study meeting

    International Nuclear Information System (INIS)

    1986-03-01

    This book is the report of fission Study Meeting held from September 19 to 21, 1985 in the Research Center for Nuclear Physics, Osaka University. The objective of this study meeting was to stimulate the research on nuclear physics in Japan, which began to show new development accompanying the advance of the research on heavy ion nuclear reaction, and to make this a new starting point. More than 50 participants from physical, chemical and engineering fields, who have interest in the theory and experiment related to nuclear fission, gathered, and the meeting was a success beyond expectation. The contents covered a wide range including nuclear smashing reaction as well as nuclear fission in a narrow sense. In this book, the gists of 28 papers are collected. (Kako, I.)

  2. Gunnison, Colorado, subpile study report

    International Nuclear Information System (INIS)

    1994-03-01

    To protect human health and the environment, the UMTRA project will remediate the uranium mill tailings site at Gunnison, Colorado. There are explicit requirements (i.e., 40 Part CFR Part 192) for the surface remediation of radiologically contaminated soils on UMTRA sites. The removal of subpile sediment to the depth required by 40 CFR Part 192 will leave in place deeper foundation sediment that is contaminated with hazardous constituents other than radium-226 and thorium-230. The Department of Energy and the Colorado Department of Health have questioned whether this contaminated soil could potentially act as a continuing source of ground water contamination even after surface remediation based on 40 CFR Part 192 is complete. To evaluate the subpile sediments as a potential source of ground water contamination, the Gunnison subpile study was initiated. This report summarizes the results and findings of this study

  3. Accelerator research studies. Progress report

    International Nuclear Information System (INIS)

    1984-06-01

    Progress is reported in both experimental studies as well as theoretical understanding of the beam transport problem. Major highlights are: (a) the completion of the first channel section with 12 periods and two matching solenoids, (b) measurements of beam transmission and emittance in this 12-lens channel, (c) extensive analytical and numerical studies of the beam transport problem in collaboration with GSI (W. Germany), (d) detailed measurements and calculations of beam propagation through one lens with spherical aberration and space charge, and (e) completion of the emittance grids at the Rutherford-Appleton Laboratory. Our main objectives in Task B of our research program are: (a) study of collective acceleration of positive ions from a localized plasma source by an intense relativistic electron beam (IREB), (b) external control of the IREB beam front by a slow-wave structure to achieve higher ion energies - the Beam Front Accelerator (BFA) concept, (c) study of ion and electron acceleration and other applications of a plasma focus device, and (d) theoretical studies in support of (a) and (b). Our research in these areas has been oriented towards obtaining an improved understanding of the physical processes at work in these experiments and, subsequently, achieving improved performance for specific potential applications

  4. TWRS LDUA utilization study report

    International Nuclear Information System (INIS)

    Rieck, R.H.

    1994-01-01

    Tank Waste Remediation Systems functional requirements were reviewed. The Light Duty Utility Arm capabilities were considered as a means to support completion of these functional requirements. The recommendation is made to continue to develop the LDUA, integrating TWRS functional needs into the design to better support completion of TWRS mission needs

  5. Functional criteria for emergency response facilities. Technical report (final)

    International Nuclear Information System (INIS)

    1981-02-01

    This report describes the facilities and systems to be used by nuclear power plant licensees to improve responses to emergency situations. The facilities include the Technical Support Center (TSC), Onsite Operational Support Center (OSC), and Nearsite Emergency Operations Facility (EOF), as well as a brief discussion of the emergency response function of the control room. The data systems described are the Safety Parameter Display System (SPDS) and Nuclear Data Link (NDL). Together, these facilities and systems make up the total Emergency Response Facilities (ERFs). Licensees should follow the guidance provided both in this report and in NUREG-0654 (FEMA-REP-1), Revision 1, for design and implementation of the ERFs

  6. Early Childhood Predictors of Post-Kindergarten Executive Function: Behavior, Parent Report, and Psychophysiology

    Science.gov (United States)

    Cuevas, Kimberly; Hubble, Morgan; Bell, Martha Ann

    2012-01-01

    Research Findings: This study examined whether children's executive functions before kindergarten would predict variance in executive functions after kindergarten. We obtained behavioral (working memory task performance), parent-reported (temperament-based inhibitory control), and psychophysiological (working memory-related changes in heart rate…

  7. Functional Impact of Sydenham's Chorea: A Case Report

    Directory of Open Access Journals (Sweden)

    Hortensia Gimeno

    2013-04-01

    Full Text Available Background: Sydenham's chorea (SC is the most common type of acquired chorea in childhood. In some cases, symptoms (most commonly described in terms of neurological signs last up to 2 years, and many cases relapse. This report describes the clinical course in terms of functional abilities following diagnosis of SC. Case report: Standardized assessments across the domains of activity and participation were administered following diagnosis, prior to and following treatment with haloperidol to measure treatment response and identify occupational therapy intervention needs. SC was observed to significantly reduce the child's participation and independence in activities of daily living. In this case, the standardized assessments administered highlighted difficulties with both motor and process skills. At 1 week after commencing haloperidol, both motor and process skills had improved. Clinically significant changes in self-care and mobility were noted with less improvement with handwriting. At 9 weeks, most symptoms and functional difficulties had resolved. Discussion: Given the process difficulties detected in this case, and the possibility of enduring symptoms, the use of functional assessments is advocated in the routine management of SC. These findings illustrate the potential for motor and non-motor sequelae in acute childhood movement disorders and related functional disabling consequences.

  8. Adult health study report, 6

    International Nuclear Information System (INIS)

    Sawada, Hisao; Kodama, Kazunori; Shimizu, Yukiko; Kato, Hiroo.

    1987-02-01

    The AHS clinical examination is conducted biennially to determine disease (not limited to disease) prevalence rates. No inquiry is made about deaths occurring between the cycle examinations. Since there has been a remarkable difference in cancer mortality by radiation dose it must be stated that the effects of atomic bomb radiation cannot be adequately assessed through a comparison of cancer prevalence rates alone. Nonetheless, in this study, an association between the prevalence rates of various cancers and radiation has been demonstrated, particularly for cancers with a relatively low lethality rate. In this group are cancers of the thyroid and breast where the association is strong, particularly in the younger age-groups. An association continued to be observed for neoplasms of the lymphatic and hematopoietic tissues, and for all cancers excluding the foregoing, for which a demonstrable association to A-bomb exposure was made at an early stage. These are important findings. Further, analysis of benign tumors suggested an increase in prevalence associated with an increase in radiation dose, a finding which was not observed in the studies of autopsied cases. This finding raises a whole series of questions relating to radiation carcinogenesis. As for other diseases, strong association of increased prevalence with increased radiation dose was observed for various thyroid diseases, anemia, cataract, and calcification of the aorta. As for physical measurements and laboratory tests, relationships to radiation dose were observed concerning hemoglobin, hematocrit, erythrocyte sedimentatioin rate, and white blood cell count (WBC), in addition to growth and development retardation in the younger survivors as described in a previous report. In general, for many diseases and measurements, the association is stronger for those exposed at younger ages. Furthermore, some effects on the aging process are also suggested by the analysis. (author)

  9. Synthesis report: System studies Bioenergy

    International Nuclear Information System (INIS)

    Berntsson, Thore

    2003-01-01

    The present report marks the end of the research program 'System studies Bioenergy' (1998-2002). The program comprised 17 projects performed at 9 universities or research institutes. All project results were studied in order to identify: contributions to our present knowledge; possible gaps of knowledge, methodology or systems perspective that still exist; and the needs for further research. The projects can be classified into the following groups: Resource potential of forest fuels; Industrial use of biofuels; Potential for synthetic fuels (pellets, bio-oils and transportation fuels); System analysis of efficient use of biofuels; and Socio-economic analyses. The total potential for available biofuel has been estimated to be 125-175 TWh/year (excl. black liquors of paper industry). The potential demand is estimated to about 123 TWh/year, or distributed into the different sectors: Industry: 26 TWh/year, Buildings and services: 35 TWh/year, District heating: 31 TWh/year, and electric power generation (incl. cogeneration in district heating): 31 TWh/year. Further research is needed in the following areas: Systems and methodology of more generic character on optimization of production, refining and use of biofuels in order to substitute fossil fuels directly or indirectly; Heat sinks/district heating in combination with cogeneration vs. other power production in a long term perspective (> 10 years), in the light of new technologies, open markets, economic and political incentives; Energy efficiency in industry, esp. paper and pulp with its unique possibility for process integration, biofuel processing and CO 2 separation; How far should the processing/refinement of biofuels go; Importance of factors of scale; New distributed (small-scale) energy technology; International trade in biofuels; Transport and handling costs for biofuel pellets in Europe; System aspects of implementation and incentives; How are biofuels affected if CO 2 from fossil fuels can be separated and

  10. NONSTANDARD PROBLEMS IN STUDYING THE PROPERTIES FUNCTIONS.

    Directory of Open Access Journals (Sweden)

    V. I. Kuzmich

    2010-06-01

    Full Text Available In this paper we consider two non-standard problems that may be offered to students for independent solution in the study of fundamental properties of functions in the course of mathematical analysis. These tasks are wearing creativity and contribute to a better understanding of students to concepts such as monotonicity and continuity of the function.

  11. Functional analysis of the exploratory studies facility

    International Nuclear Information System (INIS)

    Duffy, M.A.; Mozhi, T.A.; Kumar, P.N.; Senderling, M.S.; Lemeshewsky, W.A.

    1993-01-01

    The 'Physical System Requirements - Exploratory Studies Facility' (PSR-ESF) was developed as part of an improved management structure and procedure initiative by the OCRWM for managing the disposal of spent nuclear fuel and high-level radioactive wastes. This paper discusses the development of the PSR-EF document. Based on a functional analysis approach, this document includes results in the form of boundary diagrams, function hierarchy trees, function description tables containing a compilation of requirements, architecture tree and tables, and functional flow diagrams. The approach used ensures the flowdown and traceability of relevant requirements for the ESF design process

  12. Work Functioning Among Firefighters: A Comparison Between Self-Reported Limitations and Functional Task Performance.

    Science.gov (United States)

    MacDermid, Joy C; Tang, Kenneth; Sinden, Kathryn E; D'Amico, Robert

    2018-05-25

    Purpose Performance-based and disease indicators have been widely studied in firefighters; self-reported work role limitations have not. The aim of this study was to describe the distributions and correlations of a generic self-reported Work Limitations Questionnaire (WLQ-26) and firefighting-specific task performance-based tests. Methods Active firefighters from the City of Hamilton Fire Services (n = 293) were recruited. Participants completed the WLQ-26 to quantify on-the-job difficulties over five work domains: work scheduling (4 items), output demands (7 items), physical demands (8 items), mental demands (4 items), and social demands (3 items). A subset of participants (n = 149) were also assessed on hose drag and stair climb with a high-rise pack performance-based tests. Descriptive statistics and correlations were used to compare item/subscale performance; and to describe the inter-relationships between tests. Results The mean WLQ-26 item scores (/5) ranged from 4.1 to 4.4 (median = 5 for all items); most firefighters (54.5-80.5%) selected "difficult none of the time" response option on all items. A substantial ceiling effect was observed across all five WLQ-26 subscales as 44.0-55.6% were in the highest category. Subscale means ranged from 61.8 (social demands) to 78.7 (output demands and physical demands). Internal consistency exceeded 0.90 on all subscales. For the hose drag task, the mean time-to-completion was 48.0 s (SD = 14.5; range 20.4-95.0). For the stair climb task, the mean time-to-completion was 76.7 s (SD = 37.2; range 21.0-218.0). There were no significant correlations between self-report work limitations and performance of firefighting tasks. Conclusions The WLQ-26 measured five domains, but had ceiling effects in firefighters. Performance-based testing showed wider score range, lacked ceiling effects and did not correlate to the WLQ-26. A firefighter-specific, self-report role functioning scale may be needed to identify

  13. Mercury Study Report to Congress

    Science.gov (United States)

    EPA's Report to Congress on Mercury provides an assessment of the magnitude of U.S. mercury emissions by source, the health and environmental implications of those emissions, and the availability and cost of control technologies.

  14. A functional magnetic resonance imaging study

    Indian Academy of Sciences (India)

    MADU

    systems and ultra fast imaging techniques, such as echo planar imaging (EPI ) ... is used to understand brain organization, assessing of neurological status, and ..... J C 1998 Functional MRI studies of motor recovery after stroke;. NeuroImage 7 ...

  15. Relationship between patient-reported and objective measurements of hand function in patients with rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    S.M. Günay

    2016-12-01

    Full Text Available Rheumatoid arthritis (RA often results in impairments in upper extremities, especially in the small joints of hand. Involvement of hand brings limitations in activities of daily living. However, it is commonly observed that patient-reported functional status of hand does not always corresponds to their actual physical performance in the clinical setting. The aim of this pilot study is to investigate the relationship between patient self-reported and objectively measured hand functions in patients with RA. Twenty-six patients (51±13 years with RA diagnosis participated in the study. Hand grip and pinch (lateral, bipod, tripod strengths were measured and Jebsen Hand Function Test (JHFT was performed for objective functional performance. Duruöz Hand Index and Beck Depression Inventory - Turkish version were completed by patients. Grip and all three-pinch strength results significantly correlated with Duruöz Hand Index scores (p<0.05. JHFT results except the sentence writing also correlated with the Duruöz scores (p<0.05. Our results showed that self-reported outcome scales might be used for determining functional level of hand in patients with RA in rheumatology practice. Objective quantitative functional tests are the best methods in evaluating functional level of hand, but require valid and reliable equipment with accurate calibration. Therefore, in case of unavailability of objective assessment tools, patient-reported scales may also reflect the real status of hand functions.

  16. Insomnia and endothelial function - the HUNT 3 fitness study.

    Directory of Open Access Journals (Sweden)

    Linn B Strand

    Full Text Available BACKGROUND: Insomnia is associated with increased risk of coronary heart disease (CHD, but the underlying mechanisms are not understood. To our knowledge, no previous studies have examined insomnia in relation to endothelial function, an indicator of preclinical atherosclerosis. Our aim was to assess the association of insomnia with endothelial function in a large population based study of healthy individuals. METHODS: A total of 4 739 participants free from known cardiovascular or pulmonary diseases, cancer, and sarcoidosis, and who were not using antihypertensive medication were included in the study. They reported how often they had experienced difficulties falling asleep at night, repeated awakenings during the night, early awakenings without being able to go back to sleep, and daytime sleepiness. Endothelial function was measured by flow mediated dilation (FMD derived from the brachial artery. RESULTS: We found no consistent association between the insomnia symptoms and endothelial function in multiadjusted models, but individual insomnia symptoms may be related to endothelial function. Among women who reported early awakenings, endothelial function may be lower than in women without this symptom (p = 0.03. CONCLUSIONS: This study provided no evidence that endothelial function, an early indicator of atherosclerosis, is an important linking factor between insomnia and CHD. Further studies are needed to explore the complex interrelation between sleep and cardiovascular pathology.

  17. Impact of Androgen Deprivation Therapy on Self-Reported Cognitive Function in Men with Prostate Cancer.

    Science.gov (United States)

    Marzouk, Shireen; Naglie, Gary; Tomlinson, George; Duff Canning, Sarah; Breunis, Henriette; Timilshina, Narhari; Alibhai, Shabbir M H

    2018-03-01

    Although androgen deprivation therapy is widely used to treat prostate cancer, its effects on cognitive function are unclear. To our knowledge no prior report has examined the impact of androgen deprivation therapy on self-reported cognitive function. Three groups of men 50 years old or older who were matched on age and education were enrolled in the study, including 81 with prostate cancer starting on continuous androgen deprivation therapy, 84 controls with prostate cancer not receiving androgen deprivation therapy and 85 healthy controls. Two scales from the FACT-Cog (Functional Assessment of Cancer Therapy-Cognitive subscale) version 3 were used to assess self-reported cognitive function. Changes in cognitive scores with time were analyzed by 2 approaches, including 1) multivariable regression and 2) calculation of the proportion of subjects per group with a decrease of 1 SD or more. Multivariable regression was applied to assess predictors of a decline in self-reported cognitive function. We also examined relationships between the FACT-Cog and a neuropsychological battery of 15 tests. Mean participant age was 69 years (range 50 to 87). The mean educational level was 15 years (range 8 to 24). FACT-Cog scores were similar at baseline across the cohorts. Neither analytical approach revealed that androgen deprivation therapy was associated with changes in self-reported cognitive function on either FACT-Cog scale. Mood and fatigue correlated with changes in self-reported cognitive function. The relationship between self-reported and objective cognitive measures was weak (maximum Spearman correlation coefficient 0.14) and only 2 of 30 correlations were statistically significant. A total of 12 months of androgen deprivation therapy were not associated with self-reported cognitive function changes in older men with nonmetastatic prostate cancer. Copyright © 2018 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights

  18. Waste encapsulation and storage facility function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and a function hierarchy chart that describe what needs to be performed to deactivate Waste Encapsulation and Storage Facility (WESF)

  19. 300 Area fuel supply facilities deactivation function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and a function hierarchy chart that describe what needs to be performed to deactivate the 300 Area Fuel Supply Facilities

  20. Hand function evaluation: a factor analysis study.

    Science.gov (United States)

    Jarus, T; Poremba, R

    1993-05-01

    The purpose of this study was to investigate hand function evaluations. Factor analysis with varimax rotation was used to assess the fundamental characteristics of the items included in the Jebsen Hand Function Test and the Smith Hand Function Evaluation. The study sample consisted of 144 subjects without disabilities and 22 subjects with Colles fracture. Results suggest a four factor solution: Factor I--pinch movement; Factor II--grasp; Factor III--target accuracy; and Factor IV--activities of daily living. These categories differentiated the subjects without Colles fracture from the subjects with Colles fracture. A hand function evaluation consisting of these four factors would be useful. Such an evaluation that can be used for current clinical purposes is provided.

  1. Photoluminescence study in diaminobenzene functionalized graphene oxide

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, Abhisek, E-mail: guptaabhisek017@gmail.com, E-mail: cnssks@iacs.res.in; Saha, Shyamal K., E-mail: guptaabhisek017@gmail.com, E-mail: cnssks@iacs.res.in [Department of Materials Science, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032 (India)

    2014-10-15

    Being an excellent electronic material graphene is a very poor candidate for optoelectronic applications. One of the major strategies to develop the optical property in GO is the functionalization of graphene oxide (GO). In the present work GO sheets are functionalized by o-phenylenediamine to achieve diaminobenzene functionalized GO composite (DAB-GO). Formation of DAB-GO composite is further characterized by FTIR, UV, Raman studies. Excellent photoluminescence is observed in DAB-GO composite via passivation of the surface reactive sites by ring-opening amination of epoxides of GO.

  2. Cognitive function and the agreement between self-reported and accelerometer-accessed physical activity.

    Science.gov (United States)

    Herbolsheimer, Florian; Riepe, Matthias W; Peter, Richard

    2018-02-21

    Numerous studies have reported weak or moderate correlations between self-reported and accelerometer-assessed physical activity. One explanation is that self-reported physical activity might be biased by demographic, cognitive or other factors. Cognitive function is one factor that could be associated with either overreporting or underreporting of daily physical activity. Difficulties in remembering past physical activities might result in recall bias. Thus, the current study examines whether the cognitive function is associated with differences between self-reported and accelerometer-assessed physical activity. Cross-sectional data from the population-based Activity and Function in the Elderly in Ulm study (ActiFE) were used. A total of 1172 community-dwelling older adults (aged 65-90 years) wore a uniaxial accelerometer (activPAL unit) for a week. Additionally, self-reported physical activity was assessed using the LASA Physical Activity Questionnaire (LAPAQ). Cognitive function was measured with four items (immediate memory, delayed memory, recognition memory, and semantic fluency) from the Consortium to Establish a Registry for Alzheimer's Disease Total Score (CERAD-TS). Mean differences of self-reported and accelerometer-assessed physical activity (MPA) were associated with cognitive function in men (r s  = -.12, p = .002) but not in women. Sex-stratified multiple linear regression analyses showed that MPA declined with high cognitive function in men (β = -.13; p = .015). Results suggest that self-reported physical activity should be interpreted with caution in older populations, as cognitive function was one factor that explained the differences between objective and subjective physical activity measurements.

  3. Functional studies on the phosphatidychloride transfer protein

    NARCIS (Netherlands)

    Brouwer, A.P.M. de

    2002-01-01

    The phosphatidylcholine transfer protein (PC-TP) has been studied for over 30 years now. Despite extensive research concerning the biochemical, biophysical and structural properties of PC-TP, the function of this protein is still elusive. We have studied in vitro the folding and the mechanism of PC

  4. Nuclear spectroscopic studies. Progress report

    International Nuclear Information System (INIS)

    Bingham, C.R.; Riedinger, L.L.; Sorensen, S.P.

    1996-01-01

    This report describes progress in the experimental nuclear physics program of the University of Tennessee, Knoxville. It presents findings related to properties of high-spin states, low-energy levels of nuclei far from stability, and high-energy heavy-ion physics, as well as a brief description of the Joint Institute of Heavy Ion Research (a collaboration between the University of Tennessee, Vanderbilt University, and Oak Ridge National Laboratory) and its activities (particularly those of the last few years), and a list of publications. 89 refs., 18 figs., 5 tabs

  5. Transportek foresight study: Final report

    CSIR Research Space (South Africa)

    Rust, FC

    2004-03-31

    Full Text Available CSIR Transportek decided to undertake a business and technology foresight study in order to enhance its decision making process for the investment of its Parliamentary Grant funding. The study was divided into for phases comprising the following: A...

  6. Vitrified waste option study report

    International Nuclear Information System (INIS)

    Lopez, D.A.; Kimmitt, R.R.

    1998-02-01

    A open-quotes Settlement Agreementclose quotes between the Department of Energy and the State of Idaho mandates that all radioactive high-level waste (HLW) now stored at the Idaho Chemical Processing Plant (ICPP) will be treated so that it is ready to be moved out of Idaho for disposal by a target date of 2035. This report investigates vitrification treatment of all ICPP calcine, including the existing and future HLW calcine resulting from calcining liquid Sodium-Bearing Waste (SBW). Currently, the SBW is stored in the tank farm at the ICPP. Vitrification of these wastes is an acceptable treatment method for complying with the Settlement Agreement. This method involves vitrifying the calcined waste and casting the vitrified mass into stainless steel canisters that will be ready to be moved out of the Idaho for disposal by 2035. These canisters will be stored at the Idaho National Engineering and Environmental Laboratory (INEEL) until they are sent to a HLW national repository. The operating period for vitrification treatment will be from 2013 through 2032; all HLW will be treated and in storage by the end of 2032

  7. Vitrified waste option study report

    Energy Technology Data Exchange (ETDEWEB)

    Lopez, D.A.; Kimmitt, R.R.

    1998-02-01

    A {open_quotes}Settlement Agreement{close_quotes} between the Department of Energy and the State of Idaho mandates that all radioactive high-level waste (HLW) now stored at the Idaho Chemical Processing Plant (ICPP) will be treated so that it is ready to be moved out of Idaho for disposal by a target date of 2035. This report investigates vitrification treatment of all ICPP calcine, including the existing and future HLW calcine resulting from calcining liquid Sodium-Bearing Waste (SBW). Currently, the SBW is stored in the tank farm at the ICPP. Vitrification of these wastes is an acceptable treatment method for complying with the Settlement Agreement. This method involves vitrifying the calcined waste and casting the vitrified mass into stainless steel canisters that will be ready to be moved out of the Idaho for disposal by 2035. These canisters will be stored at the Idaho National Engineering and Environmental Laboratory (INEEL) until they are sent to a HLW national repository. The operating period for vitrification treatment will be from 2013 through 2032; all HLW will be treated and in storage by the end of 2032.

  8. Safety and Function Test Report for the SWIFT Wind Turbine

    Energy Technology Data Exchange (ETDEWEB)

    Mendoza, I.; Hur, J.

    2013-01-01

    This test was conducted as part of the U.S. Department of Energy's (DOE) Independent Testing project. This project was established to help reduce the barriers of wind energy expansion by providing independent testing results for small turbines. Three turbines where selected for testing at the National Wind Technology Center (NWTC) as a part of round two of the Small Wind Turbine Independent Testing project. Safety and Function testing is one of up to 5 tests that may be performed on the turbines. Other tests include power performance, duration, noise, and power quality. The results of the testing will provide the manufacturers with reports that may be used for small wind turbine certification.

  9. Richmond public transportation study report.

    Science.gov (United States)

    2000-05-01

    This study looked at the possible costs and benefits associated with the creation of a small deviated fixed route bus service in Richmond. It concluded that the circumstances in Richmond favor the creation of such a system. It also concluded that onl...

  10. FED baseline engineering studies report

    Energy Technology Data Exchange (ETDEWEB)

    Sager, P.H.

    1983-04-01

    Studies were carried out on the FED Baseline to improve design definition, establish feasibility, and reduce cost. Emphasis was placed on cost reduction, but significant feasibility concerns existed in several areas, and better design definition was required to establish feasibility and provide a better basis for cost estimates. Design definition and feasibility studies included the development of a labyrinth shield ring concept to prevent radiation streaming between the torus spool and the TF coil cryostat. The labyrinth shield concept which was developed reduced radiation streaming sufficiently to permit contact maintenance of the inboard EF coils. Various concepts of preventing arcing between adjacent shield sectors were also explored. It was concluded that installation of copper straps with molybdenum thermal radiation shields would provide the most reliable means of preventing arcing. Other design studies included torus spool electrical/structural concepts, test module shielding, torus seismic response, poloidal conditions in the magnets, disruption characteristics, and eddy current effects. These additional studies had no significant impact on cost but did confirm the feasibility of the basic FED Baseline concept.

  11. Preliminary study Malaa. Final report

    International Nuclear Information System (INIS)

    1996-03-01

    Factors of importance for a possible localization of a deep nuclear waste repository at Malaa in northern Sweden are mapped in this study. The geologic structures in the area have been reviewed, mostly from already existing knowledge. Existing infrastructure and necessary improvements are discussed, as well as land use and environment, employment and other social effects. 47 refs, 41 figs, 8 tabs

  12. Cost Benefit Studies. Final Report.

    Science.gov (United States)

    Weiner, Arthur; Marson, Arthur A.

    This document applies Dr. Mehar Aurora's method for conducting cost benefit studies to the Food Manufacturing Technology-Dairy and the Food Manufacturing Technology-Canning and Freezing programs offered by the Moraine Park Technical Institute. Costs to individual students enrolled in the programs include tuition, fees, housing, travel, books,…

  13. FED baseline engineering studies report

    International Nuclear Information System (INIS)

    Sager, P.H.

    1983-04-01

    Studies were carried out on the FED Baseline to improve design definition, establish feasibility, and reduce cost. Emphasis was placed on cost reduction, but significant feasibility concerns existed in several areas, and better design definition was required to establish feasibility and provide a better basis for cost estimates. Design definition and feasibility studies included the development of a labyrinth shield ring concept to prevent radiation streaming between the torus spool and the TF coil cryostat. The labyrinth shield concept which was developed reduced radiation streaming sufficiently to permit contact maintenance of the inboard EF coils. Various concepts of preventing arcing between adjacent shield sectors were also explored. It was concluded that installation of copper straps with molybdenum thermal radiation shields would provide the most reliable means of preventing arcing. Other design studies included torus spool electrical/structural concepts, test module shielding, torus seismic response, poloidal conditions in the magnets, disruption characteristics, and eddy current effects. These additional studies had no significant impact on cost but did confirm the feasibility of the basic FED Baseline concept

  14. Fusion Studies Program. Progress report

    International Nuclear Information System (INIS)

    Stacey, W.M. Jr.

    1984-01-01

    Continuation of work in two areas, impurity control and transient electromagnetics, is proposed. In the tokamak impurity control area, an innovative supplemental mechanism, NB-driven impurity flow reversal, has been developed partly under this contract; and the proposed effort is aimed at completing this development, verifying the methodology by comparison with experiment and evaluating its potential in future tokamak experiments. In the tokamak transient electromagnetics area, the proposed effort is aimed at developing a new and more efficient methodology for calculating the currents and resulting magnetic fields in the torus structure and coil systems, which will allow a detailed representation of the latter that can be coupled to the distributed-current plasma model that was implemented for vertical stability and disruption control studies in previous work under this contract; and the application of this methodology to study the control of vertical instabilities and disruptions

  15. Laser fusion study. Final report

    International Nuclear Information System (INIS)

    1975-06-01

    The following appendices are included: (1) sensor performance calculation techniques, (2) focus sensing, (3) purchased item data, (4) pointing and focusing configuration tradeoff studies, (5) false start centering sensor, (6) RCA application notes on quad delection, (7) elliptical flex pivot analysis, (8) servo mirrors cross coupling, (9) optical misalignment analysis, (10) stress induced birefrigent quarter-wave retarder, (11) data bulletin on incramute damping alloy, (12) the utilization of stepping motors, and (13) computer program listing for stepper motor load simulation

  16. Self-reported executive functioning competencies and lifetime aggression.

    Science.gov (United States)

    King, Alan R; Breen, Cody M; Russell, Tiffany D; Nerpel, Brady P; Pogalz, Colton R

    2017-05-08

    Neuropsychological research can be advanced through a better understanding of relationships between executive functioning (EF) behavioral competencies and the expression of aggressive behavior. While performance-based EF measures have been widely examined, links between self-report indices and practical real-life outcomes have not yet been established. Executive Functioning Index subscale scores in this sample (N = 579) were linked to trait hostility (Buss-Perry Aggression Questionnaire), aggression in the natural environment (Lifetime Acts of Violence Assessment), and conduct disorder symptoms prior to age 15. Significant associations were found between all of the EFI subscales (Motivational Drive, Organization, Strategic Planning, Impulse Control, and Empathy), trait aggression, and conduct disturbance. Lifetime acts of aggression were predicted by all but Organization scores. Physical injuries inflicted on other(s) were 2 to 4 times more likely to occur among respondents generating low (z < -1) EFI subscale scores. While these EFI relationships were modest in size, they are pervasive in scope. These findings provide support for the potential role of perceived EF deficits in moderating lifetime aggression.

  17. DPC loading feasibility study report

    International Nuclear Information System (INIS)

    Dafoe, R.E.; Lopez, D.A.; Williams, K.L.

    1997-11-01

    Disposal of radioactive wastes now stored at the Idaho Chemical Processing Plant at the Idaho National Engineering and Environmental Laboratory is mandated under a ''Settlement Agreement'' between the Department of Energy and the State of Idaho. This study investigates the feasibility of using the Dry Transfer Cell facility to package waste into Dual Purpose Canisters for interim storage at the adjacent Dry Storage System comprised of an interim storage pad with NUHOMS reg-sign storage modules. The wastes would then be road-ready for eventual disposal in a permanent repository. The operating period for these activities is expected to be from 2015 to 2035

  18. Individuals with knee impairments identify items in need of clarification in the Patient Reported Outcomes Measurement Information System (PROMIS®) pain interference and physical function item banks - a qualitative study.

    Science.gov (United States)

    Lynch, Andrew D; Dodds, Nathan E; Yu, Lan; Pilkonis, Paul A; Irrgang, James J

    2016-05-11

    The content and wording of the Patient Reported Outcome Measurement Information System (PROMIS) Physical Function and Pain Interference item banks have not been qualitatively assessed by individuals with knee joint impairments. The purpose of this investigation was to identify items in the PROMIS Physical Function and Pain Interference Item Banks that are irrelevant, unclear, or otherwise difficult to respond to for individuals with impairment of the knee and to suggest modifications based on cognitive interviews. Twenty-nine individuals with knee joint impairments qualitatively assessed items in the Pain Interference and Physical Function Item Banks in a mixed-methods cognitive interview. Field notes were analyzed to identify themes and frequency counts were calculated to identify items not relevant to individuals with knee joint impairments. Issues with clarity were identified in 23 items in the Physical Function Item Bank, resulting in the creation of 43 new or modified items, typically changing words within the item to be clearer. Interpretation issues included whether or not the knee joint played a significant role in overall health and age/gender differences in items. One quarter of the original items (31 of 124) in the Physical Function Item Bank were identified as irrelevant to the knee joint. All 41 items in the Pain Interference Item Bank were identified as clear, although individuals without significant pain substituted other symptoms which interfered with their life. The Physical Function Item Bank would benefit from additional items that are relevant to individuals with knee joint impairments and, by extension, to other lower extremity impairments. Several issues in clarity were identified that are likely to be present in other patient cohorts as well.

  19. Neurophysiologic studies of functional neurologic disorders.

    Science.gov (United States)

    Hallett, M

    2016-01-01

    Functional neurologic disorders are largely genuine and represent conversion disorders, where the dysfunction is unconscious, but there are some that are factitious, where the abnormality is feigned and conscious. Malingering, which can have the same manifestations, is similarly feigned, but not considered a genuine disease. There are no good methods for differentiating these three entities at the present time. Physiologic studies of functional weakness and sensory loss reveal normal functioning of primary motor and sensory cortex, but abnormalities of premotor cortex and association cortices. This suggests a top-down influence creating the dysfunction. Studies of functional tremor and myoclonus show that these disorders utilize normal voluntary motor structures to produce the involuntary movements, again suggesting a higher-level abnormality. Agency is abnormal and studies shows that dysfunction of the temporoparietal junction may be a correlate. The limbic system is overactive and might initiate involuntary movements, but the mechanism for this is not known. The limbic system would then be the source of top-down dysfunction. It can be speculated that the involuntary movements are involuntary due to lack of proper feedforward signaling. © 2016 Elsevier B.V. All rights reserved.

  20. Plutonium Finishing Plant transition project function analysis report

    International Nuclear Information System (INIS)

    Lund, D.P.

    1995-09-01

    The document contains the functions, function definitions, function interfaces, function interface definitions, Input Computer Automated Manufacturing Definition (IDEFO) diagrams, and function hierarchy charts that describe what needs to be performed to deactivate PFP and to continue safe storage, treatment and disposition of Plutonium and High Enriched Uranium

  1. Density functional study of gamma-aminopropyltriethoxysilane

    International Nuclear Information System (INIS)

    Bistricic, L; Volovsek, V; Daani, V; Leskovac, M

    2006-01-01

    Density functional theory calculations using Becke's three-parameter exchange functional in combination with the Lee-Young-Parr correlation functional (B3-LYP) and standard 6-311 + G(d,p) basis set were carried out to study the conformational stability and vibrational spectra of gamma-aminopropyltriethoxysilane. Calculations reveal the existence of two stable conformers trans and gauche. The calculated energy for the gauche conformation was found to be 608 cm -1 above the minimum energy of the trans conformation. Temperature dependence of Raman spectra of liquid APTES and DFT calculation enabled us to identify the vibrational bands characteristic for both conformers. It has been shown that there is an increase in the population of gauche conformer with increasing temperature

  2. Accelerator research studies. Progress report

    International Nuclear Information System (INIS)

    1983-07-01

    The major goal of this project is to study the effects that lead to emittance growth and limitation of beam current and brightness in periodic focusing systems (including linear accelerators). This problem is of great importance for all accelerator applications requiring high intensity beams with small emittance such as heavy ion fusion, spallation neutron sources and high energy physics. In the latter case, future machines must not only provide higher energies (in the range of 10 to 100 TeV), but also higher luminosities than the existing facilities. This implies considerably higher phase-space density of the particle beam produced by the injector linac, i.e., the detrimental emittance growth and concurrent beam loss observed in existing linacs must be avoided

  3. International Study Group Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Raubenheimer, Tor O

    2000-07-18

    The focus of the ISG work was on advancing the accelerator design and supporting technologies. This is a complex process which involves a close interaction between theoretical analysis of the collider design and R and D progress on hardware components. The sequence of efforts took place roughly in the following order: (1) Optimization of the collider parameters and definition of system and subsystem requirements, (2) Identification of design strategies and options, and (3) Development of specific technologies to achieve these requirements. Development and testing of the required components, and R and D on manufacturing techniques have been important activities of the ISG. Experiments at the major test facilities such as the ATF at KEK and ASSET at SLAC have also played a significant role in the ISG studies.

  4. Nuclear spectroscopic studies. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Bingham, C.R.; Guidry, M.W.; Riedinger, L.L.; Sorensen, S.P.

    1993-02-08

    The Nuclear Physics group at the University of Tennessee, Knoxville is involved in several aspects of heavy-ion physics including both nuclear structure and reaction mechanisms. While our main emphasis is on experimental problems involving heavy-ion accelerators, we have maintained a strong collaboration with several theorists in order to best pursue the physics of our measurements. During the last year we have led several experiments at the Holifield Heavy Ion Research Facility and participated in others at Argonne National Laboratory. Also, we continue to be very active in the collaboration to study ultra-relativistic heavy ion physics utilizing the SPS accelerator at CERN in Geneva, Switzerland and in a RHIC detector R&D project. Our experimental work is in four broad areas: (1) the structure of nuclei at high angular momentum, (2) heavy-ion induced transfer reactions, (3) the structure of nuclei far from stability, and (4) ultra-relativistic heavy-ion physics. The results of studies in these particular areas will be described in this document in sections IIA, IIB, IIC, and IID, respectively. Areas (1), (3), and (4) concentrate on the structure of nuclear matter in extreme conditions of rotational motion, imbalance of neutrons and protons, or very high temperature and density. Area (2) pursues the transfer of nucleons to states with high angular momentum, both to learn about their structure and to understand the transfer of particles, energy, and angular momentum in collisions between heavy ions. An important component of our program is the strong emphasis on the theoretical aspects of nuclear structure and reactions.

  5. Subject search study. Final report

    International Nuclear Information System (INIS)

    Todeschini, C.

    1995-01-01

    The study gathered information on how users search the database of the International Nuclear Information System (INIS), using indicators such as Subject categories, Controlled terms, Subject headings, Free-text words, combinations of the above. Users participated from the Australian, French, Russian and Spanish INIS Centres, that have different national languages. Participants, both intermediaries and end users, replied to a questionnaire and executed search queries. The INIS Secretariat at the IAEA also participated. A protocol of all search strategies used in actual searches in the database was kept. The thought process for Russian and Spanish users is predominantly non-English and also the actual initial search formulation is predominantly non-English among Russian and Spanish users while it tends to be more in English among French users. A total of 1002 searches were executed by the five INIS centres including the IAEA. The search protocols indicate the following search behaviour: 1) free text words represent about 40% of search points on an average query; 2) descriptors used as search keys have the widest range as percentage of search points, from a low of 25% to a high of 48%; 3) search keys consisting of free text that coincides with a descriptor account for about 15% of search points; 4) Subject Categories are not used in many searches; 5) free text words are present as search points in about 80% of all searches; 6) controlled terms (descriptors) are used very extensively and appear in about 90% of all searches; 7) Subject Headings were used in only a few percent of searches. From the results of the study one can conclude that there is a greater reluctance on the part of non-native English speakers in initiating their searches by using free text word searches. Also: Subject Categories are little used in searching the database; both free text terms and controlled terms are the predominant types of search keys used, whereby the controlled terms are used more

  6. Nuclear spectroscopic studies: Progress report

    International Nuclear Information System (INIS)

    Bingham, C.R.; Guidry, M.W.; Riedinger, L.L.; Sorensen, S.P.

    1989-01-01

    The Nuclear Physics Group at the University of Tennessee, Knoxville (UTK) is involved in several aspects of heavy-ion physics including both nuclear structure and reaction mechanisms. While our main emphasis is on experimental problems involving heavy-ion accelerators, we have maintained a strong collaboration with several theorists in order to best pursue the physics of our measurements. During the last year we have led experiments at the Holifield Heavy Ion Research Facility (HHIRF) and the Niels Bohr Institute Tandem Accelerator. Also, we are active in a collaboration (WA80) to study ultra-relativistic heavy ion physics utilizing the SPS accelerator at CERN in Geneva, Switzerland. Our experimental work is four broad areas: (1) the structure of nuclei at high angular momentum, (2) heavy-ion induced transfer reactions, (3) the structure of nuclei far from stability, and (4) ultra-relativistic heavy-ion physics. These results will be described in this document. Areas (1), (3), and (4) concentrate on the structure of nuclear matter in extreme conditions of rotational motion, imbalance of neutrons and protons, or very high temperature and density. Area (2) pursues the transfer of nucleons to states with high angular momentum, both to learn about their structure and to understand the transfer of particles, energy, and angular momentum in collisions between heavy ions. An important component of our program is the strong emphasis on the theoretical aspects of nuclear structure and reactions

  7. WERF MACT Feasibility Study Report

    Energy Technology Data Exchange (ETDEWEB)

    B. Bonnema; D. Moser; J. Riedesel; K. Kooda; K. Liekhus; K. Rebish; S. Poling

    1998-11-01

    This study was undertaken to determine the technical feasibility of upgrading the Waste Experimental Reduction Facility (WERF) at the Idaho National Engineering and Environmental Laboratory to meet the offgas emission limits proposed in the Maximum Achievable Control Technologies (MACT)rule. Four practicable offgas treatment processes were identified, which, if installed, would enable the WERF to meet the anticipated MACT emission limits for dioxins and furans (D/F), hydrochloric acid (HCI), and mercury (Hg). Due to the three-year time restraint for MACT compliance, any technology chosen for the upgrade must be performed within the general plant project funding limit of $5 M. The option selected consists of a partial-quench evaporative cooler with dry sorbent injection for HCI removal followed by a sulfur-impregnated activated carbon bed for Hg control. The planning cost estimate for implementing the option is $4.17 M (with 24% contingency). The total estimated cost includes capital costs, design and construction costs, and project management costs. Capital costs include the purchase of a new offgas evaporative cooler, a dry sorbent injection system with reagent storage, a new fabric filter baghouse, a fixed carbon bed absorber, and two offgas induced draft exhaust fans. It is estimated that 21 months will be required to complete the recommended modification to the WERF. The partial-quench cooler is designed to rapidly cool the offgas exiting the secondary combustion chamber to minimize D/F formation. Dry sorbent injection of an alkali reagent into the offgas is recommended. The alkali reacts with the HCI to form a salt, which is captured with the fly ash in the baghouse. A design HCI removal efficiency of 97.2% allows for the feeding 20 lbs/hr of chlorine to the WERF incinerator. The sorbent feed rate can be adjusted to achieve the desired HCI removal efficiency. A fixed bed of sulfur-impregnated carbon was conservatively sized for a total Hg removal capacity when

  8. Report on task 4.1.3. - Survey of anticipated functional requirement for operator support systems

    International Nuclear Information System (INIS)

    Silvani, V.

    1993-01-01

    This is a preliminary report summarizing some topics related to the surveillance activity on anticipated functional requirements of the Operator Support Systems (OSS's) in NPP's. Additional information are expected will be available by analyzing the questionnaire. Functionalities examined are those referring to system functions, user's needs, technology trend, standard status. For practical purposes this document is divided in two main sections: the first section presents a summary of major OSS requirements and related problems as derived from the existing literature; the second section presents a study of OSS to be used to support the operator training presently under development in ENEA. Finally, appendix 2 reports a summary of major functions performed by the OSS's presently in operation or under development in laboratories. Refs, 1 tab

  9. Social Cognition, Executive Functions and Self-Report of Psychological Distress in Huntington's Disease

    DEFF Research Database (Denmark)

    Larsen, Ida Unmack; Vinther-Jensen, Tua; Nielsen, Jørgen Erik

    2016-01-01

    OBJECTIVE: Huntington's disease (HD) is characterized by motor symptoms, psychiatric symptoms and cognitive impairment in, inter alia, executive functions and social cognition. The aim of this study was to investigate the relationship between subjective feeling of psychological distress using...... a self-report questionnaire and performances on tests of executive functions and social cognition in a large consecutive cohort of HD patients. METHOD: 50 manifest HD patients were tested in social cognition and executive functions and each answered a self-report questionnaire about current status...... psychological distress was significantly associated with worse performances on social cognitive tests (mean absolute correlation .34) and that there were no significant correlations between perceived psychological distress and performance on tests of executive functions. The correlations between perceived...

  10. Comparison of self-reported and performance-based measures of functional ability in elderly patients in an emergency department

    DEFF Research Database (Denmark)

    Nielsen, Louise M.; Kirkegaard, Hans; Østergaard, Lisa Gregersen

    2016-01-01

    Background Assessment of functional ability in elderly patients is often based on self-reported rather than performance-based measures. This study aims to compare self-reported and performance-based measures of functional ability in a population of elderly patients at an emergency department (ED)...

  11. Rendezvous, proximity operations and capture quality function deployment report

    Science.gov (United States)

    Lamkin, Stephen L. (Editor)

    1991-01-01

    Rendezvous, Proximity Operations, and Capture (RPOC) is a missions operations area which is extremely important to present and future space initiatives and must be well planned and coordinated. To support this, a study team was formed to identify a specific plan of action using the Quality Function Deployment (QFD) process. This team was composed of members from a wide spectrum of engineering and operations organizations which are involved in the RPOC technology area. The key to this study's success is an understanding of the needs of potential programmatic customers and the technology base available for system implementation. To this end, the study team conducted interviews with a variety of near term and future programmatic customers and technology development sponsors. The QFD activity led to a thorough understanding of the needs of these customers in the RPOC area, as well as the relative importance of these needs.

  12. Rendezvous, proximity operations and capture quality function deployment report

    Science.gov (United States)

    Lamkin, Stephen L.

    1991-12-01

    Rendezvous, Proximity Operations, and Capture (RPOC) is a missions operations area which is extremely important to present and future space initiatives and must be well planned and coordinated. To support this, a study team was formed to identify a specific plan of action using the Quality Function Deployment (QFD) process. This team was composed of members from a wide spectrum of engineering and operations organizations which are involved in the RPOC technology area. The key to this study's success is an understanding of the needs of potential programmatic customers and the technology base available for system implementation. To this end, the study team conducted interviews with a variety of near term and future programmatic customers and technology development sponsors. The QFD activity led to a thorough understanding of the needs of these customers in the RPOC area, as well as the relative importance of these needs.

  13. Functional MR imaging of psychogenic amnesia: a case report

    International Nuclear Information System (INIS)

    Yang, Jong Chul; Jeong, Gwang Woo; Lee, Moo Suk; Kang, Heoung Keun; Eun, Sung Jong; Lee, Yo Han; Kim, Yong Ku

    2005-01-01

    We present here a case in which functional MR imaging (fMRI) was done for a patient who developed retrograde psychogenic amnesia for a four year period of her life history after a severe stressful event. We performed the fMRI study for a face recognition task using stimulation with three kinds of face photographs: recognizable familiar faces, unrecognizable friends' faces due to the psychogenic amnesia, and unfamiliar control faces. Different activation patterns between the recognizable faces and unrecognizable faces were found in the limbic area, and especially in the amygdala and hippocampus

  14. Functional MR imaging of psychogenic amnesia: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Jong Chul; Jeong, Gwang Woo; Lee, Moo Suk; Kang, Heoung Keun; Eun, Sung Jong; Lee, Yo Han [Chonnam National Univeristy Hospital, Chonnam National University Medical School, Kwangju (Korea, Republic of); Kim, Yong Ku [Korea University Ansan Hospital, Ansan (Korea, Republic of)

    2005-09-15

    We present here a case in which functional MR imaging (fMRI) was done for a patient who developed retrograde psychogenic amnesia for a four year period of her life history after a severe stressful event. We performed the fMRI study for a face recognition task using stimulation with three kinds of face photographs: recognizable familiar faces, unrecognizable friends' faces due to the psychogenic amnesia, and unfamiliar control faces. Different activation patterns between the recognizable faces and unrecognizable faces were found in the limbic area, and especially in the amygdala and hippocampus.

  15. Visual function alterations in essential tremor: A case report

    Directory of Open Access Journals (Sweden)

    David P. Piñero

    2015-09-01

    Full Text Available Our purpose is to report alterations in contrast sensitivity function (CSF and in the magno, parvo and koniocellular visual pathways by means of a multichannel perimeter in case of an essential tremor (ET. A complete evaluation of the visual function was performed in a 69-year old patient, including the analysis of the chromatic discrimination by the Fansworth–Munsell 100 hue test, the measurement of the CSF by the CSV-1000E test, and the detection of potential alteration patterns in the magno, parvo and koniocellular visual pathways by means of a multichannel perimeter. Visual acuity and intraocular pressure (IOP were within the ranges of normality in both eyes. No abnormalities were detected in the fundoscopic examination and in the optical coherence tomography (OCT exam. The results of the color vision examination were also within the ranges of normality. A significant decrease in the achromatic CSFs for right eye (RE and left eye (LE was detected for all spatial frequencies. The statistical global values provided by the multichannel perimeter confirms that there were significant absolute sensitivity losses compared to the normal pattern in RE. In the LE, only a statistically significant decrease in sensitivity was detected for the blue-yellow (BY channel. The pattern standard deviation (PSD values obtained in our patient indicated that there were significant localized losses compared to the normality pattern in the achromatic channel of the RE and in the red-green (RG channel of the LE. Some color vision alterations may be present in ET that cannot be detected with conventional color vision tests, such as the FM 100 Hue.

  16. Progress in studies on nucleolus functions

    International Nuclear Information System (INIS)

    Chang Lei; Zhou Guangming

    2011-01-01

    Nucleoli is the sites for ribosome synthesis and processing, however, recent approaches have revealed that it is also involved in variety of cellular processes, especially the cellular stress response. As sensors, nucleoli regulate the localization of nucleolar proteins, such as (Alternate Reading Frame, ARF), and the activation of key factors, such as P53, and consequently mediate the cellular stress response.In this paper, recent progress in the studies on nucleolar functions in cellular stress response to radiation is reviewed. (authors)

  17. Self-reported prevalence, description and management of pain in adults with haemophilia: methods, demographics and results from the Pain, Functional Impairment, and Quality of life (P-FiQ) study.

    Science.gov (United States)

    Witkop, M; Neff, A; Buckner, T W; Wang, M; Batt, K; Kessler, C M; Quon, D; Boggio, L; Recht, M; Baumann, K; Gut, R Z; Cooper, D L; Kempton, C L

    2017-07-01

    Haemophilia is characterized by frequent haemarthrosis, leading to acute/chronic joint pain. To assess self-reported prevalence, description and management of pain in adult males with mild-to-severe haemophilia and history of joint pain/bleeding. Participants completed a pain survey and five patient-reported outcome instruments assessing pain, functional impairment and health-related quality of life (HRQoL). Of 381 participants enrolled, median age was 34 years; 77% had haemophilia A, 71% had severe disease and 65% were overweight/obese. Many (56%) were not receiving routine infusions; 30% never received routine infusions. During the prior 6 months, 20% experienced acute pain, 34% chronic pain and 32% both acute/chronic pain. Subjects with both acute/chronic pain (vs. none, acute or chronic) were more likely to be depressed (30% vs. 0-15%), obese (35% vs. 20-29%) and have lower HRQoL (mean EQ-5D visual analog scale, 69 vs. 83-86) and function (median overall Hemophilia Activities List, 60 vs. 88-99). Most common analgesics used for acute/chronic pain during the prior 6 months were acetaminophen (62%/55%) and non-steroidal anti-inflammatory drugs (34%/49%); most common non-pharmacologic strategies were ice (65%/33%) and rest (51%/33%). Hydrocodone-acetaminophen was the most common opioid for both acute/chronic pain (30%); other long-acting opioids were infrequently used specifically for chronic but not acute pain (morphine, 7%; methadone, 6%; fentanyl patch, 2%). Patients with chronic pain, particularly those with both acute/chronic pain, frequently experience psychological issues, functional disability and reduced HRQoL. Treatment strategies for acute pain (e.g. routine infusions to prevent bleeding) and for chronic pain (e.g. long-acting opioids) may be underused. © 2017 The Authors. Haemophilia Published by John Wiley & Sons Ltd.

  18. Physiotherapy improves patient reported shoulder function and health status in patients with subacromial impingement syndrome

    DEFF Research Database (Denmark)

    Storgaard, Filip Holst; Pedersen, Christina Gravgaard; Jensen, Majbritt Lykke

    Physiotherapy improves patient reported shoulder function and health status in patients with subacromial impingement syndrome.......Physiotherapy improves patient reported shoulder function and health status in patients with subacromial impingement syndrome....

  19. The Danish National Case Study Report

    DEFF Research Database (Denmark)

    Brodersen, Søsser; Jørgensen, Michael Søgaard

    Three case studies from Danish science shops within the environmental field are analysed with respect to societal background, interaction between the involved actors and the societal impact of the co-operation. The report is one of the seven national case study reports from the EU...

  20. Head Start Impact Study. Technical Report

    Science.gov (United States)

    Puma, Michael; Bell, Stephen; Cook, Ronna; Heid, Camilla; Shapiro, Gary; Broene, Pam; Jenkins, Frank; Fletcher, Philip; Quinn, Liz; Friedman, Janet; Ciarico, Janet; Rohacek, Monica; Adams, Gina; Spier, Elizabeth

    2010-01-01

    This Technical Report is designed to provide technical detail to support the analysis and findings presented in the "Head Start Impact Study Final Report" (U.S. Department of Health and Human Services, January 2010). Chapter 1 provides an overview of the Head Start Impact Study and its findings. Chapter 2 provides technical information on the…

  1. Walking smoothness is associated with self-reported function after accounting for gait speed.

    Science.gov (United States)

    Lowry, Kristin A; Vanswearingen, Jessie M; Perera, Subashan; Studenski, Stephanie A; Brach, Jennifer S

    2013-10-01

    Gait speed has shown to be an indicator of functional status in older adults; however, there may be aspects of physical function not represented by speed but by the quality of movement. The purpose of this study was to determine the relations between walking smoothness, an indicator of the quality of movement based on trunk accelerations, and physical function. Thirty older adults (mean age, 77.7±5.1 years) participated. Usual gait speed was measured using an instrumented walkway. Walking smoothness was quantified by harmonic ratios derived from anteroposterior, vertical, and mediolateral trunk accelerations recorded during overground walking. Self-reported physical function was recorded using the function subscales of the Late-Life Function and Disability Instrument. Anteroposterior smoothness was positively associated with all function components of the Late-Life Function and Disability Instrument, whereas mediolateral smoothness exhibited negative associations. Adjusting for gait speed, anteroposterior smoothness remained associated with the overall and lower extremity function subscales, whereas mediolateral smoothness remained associated with only the advanced lower extremity subscale. These findings indicate that walking smoothness, particularly the smoothness of forward progression, represents aspects of the motor control of walking important for physical function not represented by gait speed alone.

  2. Renal function study using I-123-OIH

    International Nuclear Information System (INIS)

    Yamashita, Masato; Osaka, Yosio; Aikawa, Ichiro

    1989-01-01

    Twenty-eight renal function studies were performed in 24 patients with renal diseases with I-123 orthoiodohippurate (I-123 OIH). Neither side effects nor abnormal laboratory values were attributable to I-123 OIH. Imaging with Tc-99m diethylene triaminepentaacetic acid (DTPA) was also performed in 20 patients within one week after I-123 imaging. Findings with I-123 OIH and Tc-99m DTPA were similar in all except for two patients. The two patients had received cadaveric renal transplantation. One patient presented with acute tubular necrosis and the other with chronic renal rejection. In these patients, I-123 imaging showed vascular stricture and Tc-99m imaging showed a decreased glomerular function. Because I-123 OIH and Tc-99m DTPA had different pharmacodynamics, combined use of the two imaging agents may be useful in evaluating renal rejection or acute tubular necrosis. (N.K.)

  3. The functional genomic studies of curcumin.

    Science.gov (United States)

    Huminiecki, Lukasz; Horbańczuk, Jarosław; Atanasov, Atanas G

    2017-10-01

    Curcumin is a natural plant-derived compound that has attracted a lot of attention for its anti-cancer activities. Curcumin can slow proliferation of and induce apoptosis in cancer cell lines, but the precise mechanisms of these effects are not fully understood. However, many lines of evidence suggested that curcumin has a potent impact on gene expression profiles; thus, functional genomics should be the key to understanding how curcumin exerts its anti-cancer activities. Here, we review the published functional genomic studies of curcumin focusing on cancer. Typically, a cancer cell line or a grafted tumor were exposed to curcumin and profiled with microarrays, methylation assays, or RNA-seq. Crucially, these studies are in agreement that curcumin has a powerful effect on gene expression. In the majority of the studies, among differentially expressed genes we found genes involved in cell signaling, apoptosis, and the control of cell cycle. Curcumin can also induce specific methylation changes, and is a powerful regulator of the expression of microRNAs which control oncogenesis. We also reflect on how the broader technological progress in transcriptomics has been reflected on the field of curcumin. We conclude by discussing the areas where more functional genomic studies are highly desirable. Integrated OMICS approaches will clearly be the key to understanding curcumin's anticancer and chemopreventive effects. Such strategies may become a template for elucidating the mode of action of other natural products; many natural products have pleiotropic effects that are well suited for a systems-level analysis. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. 1974 annual report to Congress. Part one: operating and developmental functions. Part two: regulatory functions

    International Nuclear Information System (INIS)

    1974-01-01

    This report is of a nontechnical nature, with numerous photographs. The first part contains chapters on the reorganization of the AEC to ERDA and NRC, the history of the AEC: 1946--1975, energy research and development, breeder reactors, public health and safety, fusion research, environmental research, biomedical research, physical research, nuclear materials, national security, and management of radioactive waste. The part on regulatory functions contains chapters on nuclear regulation in 1974, 1974 nuclear power licensing, fuels and materials licensing, nuclear materials and plant protection, regulatory operations, nuclear standards development, public participation in regulation, and state and international liaison. Appendixes give membership of various boards and committees, changes in rules and regulations, a list of AEC regulatory guides, and a table of nuclear electric generating units in operation, under construction, or planned. (U.S.)

  5. Self-reported physical activity is associated with cognitive function in lean, but not obese individuals.

    Science.gov (United States)

    Galioto Wiedemann, R; Calvo, D; Meister, J; Spitznagel, M B

    2014-12-01

    Convergent evidence demonstrates that greater physical activity is associated with better cognitive functioning across many patient and healthy samples. However, this relationship has not been well examined among obese individuals and remains unclear. The present study examined the relationship between performance-based measures of attention/executive function and self-reported physical activity, as measured by the International Physical Activity Questionnaire, among lean (n = 36) and obese (n = 36) college students. Lean individuals performed better than obese individuals on measures of attention/executive function. No significant differences in self-reported physical activity emerged between weight groups. Higher self-reported physical activity was related to faster reaction time in lean individuals but slower reaction time in obese individuals. Additionally, in lean individuals, higher levels of self-reported physical activity were related to more errors on a task of speeded inhibitory control. The results are consistent with previous research demonstrating that greater physical activity is associated with faster attention and executive function abilities in healthy samples and highlight the importance of examining reaction time and accuracy indices separately on these measures. The lack of association among obese individuals may be due in part to inaccurate self-report in the current study. Additionally, the cognitive consequences of obesity may outweigh the benefits of physical activity in this group. Future work should investigate these associations in obese individuals using physical activity interventions, as well as a combination of self-report and objective measures to investigate discrepancies in reporting. © 2014 The Authors. Clinical Obesity © 2014 World Obesity.

  6. Ramakrishna Mission initiative impact study: final report

    Energy Technology Data Exchange (ETDEWEB)

    Chaurey, A.

    2000-07-06

    This report has been prepared by the Tata Energy Research Institute (TERI) for the National Renewable Energy Laboratory. It presents the results of the evaluation and impact assessment of solar photovoltaic lighting systems in the region of Sunderbans, West Bengal, that were deployed by a reputable non-governmental organization (Ramakrishna Mission) under the auspices of the INDO-US collaborative project. The objectives of the study were to evaluate the solar photovoltaic systems for their impact on the individual households as well as on the community, to assess the effectiveness of the implementation and financial mechanisms, and to draw a long-term strategy for NREL's activities in Sunderbans based on case studies of similar interventions. Under the project, provision was made to supply 300 domestic lighting systems (DLS) based on 53-Wp module capacity to individual households and a few other systems such as for lighting, medical refrigeration, and pumping water to community centers. For this study, 152 households were surveyed, of which 29 had also been a part of earlier pre- and post-installation surveys, 47 had been a part of the earlier post-installation survey, and 76 were households that were surveyed for the first time. A set of 46, out of the total 152 households, was selected for evaluating the systems for their technical performance with respect to module output, condition of the battery, and daily energy consumption. Of the total 300 modules, 2 had been stolen, 9 out of the total 300 batteries needed to be replaced, and 10 out of the 300 charge controllers were non-functional. The statistics for the surveyed households indicate 32 luminaire-related faults (blackening or flickering of compact fluorescent lights) and 11 other faults related to fuses, switches, etc.

  7. Functional MR imaging and traumatic paraplegia: preliminary report.

    Science.gov (United States)

    Sabbah, P; Lévêque, C; Pfefer, F; Nioche, C; Gay, S; Sarrazin, J L; Barouti, H; Tadie, M; Cordoliani, Y S

    2000-12-01

    To evaluate residual activity in the sensorimotor cortex of the lower limbs in paraplegia. 5 patients suffering from a complete paralysis after traumatic medullar lesion (ASIA=A). Clinical evaluation of motility and sensitivity. 1. Control functional MR study of the sensorimotor cortex during simultaneous movements of hands, imaginary motor task and passive hands stimulation. 2. Concerning the lower limbs, 3 fMRI conditions: 1-patient attempts to move his toes with flexion-extension, 2-mental imagery task of the same movement, 3-peripheral passive proprio-somesthesic stimulation (squeezing) of the big toes. Activations were observed in the primary sensorimotor cortex (M1), premotor regions and in the supplementary motor area (SMA) during movement and mental imaginary tasks in the control study and during attempt to move and mental imaginary tasks in the study concerning the lower limbs. Passive somesthesic stimulation generated activation posterior to the central sulcus for 2 patients. Activations in the sensorimotor cortex of the lower limbs can be generated either by attempting to move or mental evocation. In spite of a clinical evaluation of complete paraplegia, fMRI can show a persistence of sensitive anatomic conduction, confirmed by Somesthesic Evoked Potentials.

  8. Studying Functions of All Yeast Genes Simultaneously

    Science.gov (United States)

    Stolc, Viktor; Eason, Robert G.; Poumand, Nader; Herman, Zelek S.; Davis, Ronald W.; Anthony Kevin; Jejelowo, Olufisayo

    2006-01-01

    A method of studying the functions of all the genes of a given species of microorganism simultaneously has been developed in experiments on Saccharomyces cerevisiae (commonly known as baker's or brewer's yeast). It is already known that many yeast genes perform functions similar to those of corresponding human genes; therefore, by facilitating understanding of yeast genes, the method may ultimately also contribute to the knowledge needed to treat some diseases in humans. Because of the complexity of the method and the highly specialized nature of the underlying knowledge, it is possible to give only a brief and sketchy summary here. The method involves the use of unique synthetic deoxyribonucleic acid (DNA) sequences that are denoted as DNA bar codes because of their utility as molecular labels. The method also involves the disruption of gene functions through deletion of genes. Saccharomyces cerevisiae is a particularly powerful experimental system in that multiple deletion strains easily can be pooled for parallel growth assays. Individual deletion strains recently have been created for 5,918 open reading frames, representing nearly all of the estimated 6,000 genetic loci of Saccharomyces cerevisiae. Tagging of each deletion strain with one or two unique 20-nucleotide sequences enables identification of genes affected by specific growth conditions, without prior knowledge of gene functions. Hybridization of bar-code DNA to oligonucleotide arrays can be used to measure the growth rate of each strain over several cell-division generations. The growth rate thus measured serves as an index of the fitness of the strain.

  9. Relationship between physical performance and self-reported function in healthy individuals across the lifespan.

    Science.gov (United States)

    Baldwin, Jennifer N; McKay, Marnee J; Hiller, Claire E; Moloney, Niamh; Nightingale, Elizabeth J; Burns, Joshua

    2017-08-01

    Functional outcome measures in clinical trials of musculoskeletal conditions need to be meaningful to individuals. To investigate the relationship between physical performance and self/proxy-reported function in 1000 healthy children and adults. Cross-sectional observational study (1000 Norms Project). One thousand males and females aged 3-101 years, healthy by self-report and without major physical disability, were recruited. Twelve performance-based tests were analysed: vertical and long jump, two hand dexterity tests, four balance tests, stepping reaction time, 30-second chair stand, timed up-and-down stairs, and six-minute walk. Self/proxy-reported function was assessed using the Infant-Toddler Quality of Life questionnaire, Child Health Questionnaire, Assessment of Quality of Life (AQoL)-6D Adolescent, AQoL-8D, International Physical Activity Questionnaire and work ability question. Bivariate and multivariate correlational analyses were constructed for infants (3-4y), children (5-10y), adolescents (11-17y), adults (18-59y) and older adults (60+). Socio-demographic characteristics were similar to the Australian population. Among infants/children, greater jump and sit-to-stand performance correlated with higher proxy-reported function (p  0.05). Greater jump, dexterity, balance, reaction time, sit-to-stand, stair-climbing and six-minute walk performance correlated with higher self-reported function in adults (r = -0.097 to.231; p physical measures which could form the basis of age-appropriate functional scales for clinical trials of musculoskeletal conditions. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Early patient-reported outcomes versus objective function after total hip and knee arthroplasty

    DEFF Research Database (Denmark)

    Luna, I E; Kehlet, H; Peterson, B

    2017-01-01

    AIMS: The purpose of this study was to assess early physical function after total hip or knee arthroplasty (THA/TKA), and the correlation between patient-reported outcome measures, physical performance and actual physical activity (measured by actigraphy). PATIENTS AND METHODS: A total of 80...... patients aged 55 to 80 years undergoing THA or TKA for osteoarthritis were included in this prospective cohort study. The main outcome measure was change in patient reported hip or knee injury and osteoarthritis outcome score (HOOS/KOOS) from pre-operatively until post-operative day 13 (THA) or 20 (TKA...

  11. FunSETL–Functional Reporting for ERP Systems

    DEFF Research Database (Denmark)

    Nissen, Michael Nebel; Larsen, Ken Friis

    2008-01-01

    One of the essential features of enterprise resource planning systems is the ability to provide the users and decision makers with reports on how the enterprise is running, and to enable the enterprise to provide the authorities the required legal reports.  By their nature these reports needs to ...

  12. Crime Self-Reporting Study: Phase 1

    National Research Council Canada - National Science Library

    Buck, Kelly

    2004-01-01

    The PERSEREC Crime Self-Reporting Study covers criminal record checks conducted in CY00 on 14,470 subjects of DoD security clearance investigations, including uniformed military, civilian, and contractor personnel...

  13. Theoretical studies of controlled fusion: Final report

    International Nuclear Information System (INIS)

    Krall, N.A.

    1987-01-01

    This report summarizes the results of a study of low frequency stability in the Field Reversed Configuration (FRC), with emphasis on the transport resulting from this stability behavior. 11 refs., 5 figs., 2 tabs

  14. Technical activities report: Mechanical development studies

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, W.K.

    1952-05-01

    This monthly progress report covers activities in the following areas: pile control; shielding studies; process tube assembly; pile operating equipment; power recovery; pile piping; and test laboratory. A detailed discussion is given for each topic.

  15. Zeolite function studied by neutron diffraction

    International Nuclear Information System (INIS)

    Newsam, J.M.

    1988-01-01

    Some recent figures relating to industrial uses of zeolites are summarized. Recent advances in the application of neutron diffraction to zeolite science are overviewed, with particular emphasis on powder diffraction (PND) results. Single crystal neutron diffraction studies of some 17 hydrated natural and synthetic zeolites have now appeared and they provide a consistent picture of zeolite-water interactions. Complete PND studies of hydrated synthetic ABW- and SOD-framework zeolites have also been reported. Other PND studies have explored the structural consequences of non-framework cation exchange, of framework modification by dealumination, and of framework cation substitution. Relatively simple zeolite-hydrocarbon sorbate complexes that have been studied include benzene in zeolite Y, and benzene and pyridine in zeolite L. Areas that are well poised for further development include further extensions to lower symmetry systems, the use of PND data for zeolite structure solution, studies at elevated temperatures and pressures, and further studies of zeolite sorbate complexes. (author) 68 refs., 7 figs

  16. PUREX source Aggregate Area management study report

    International Nuclear Information System (INIS)

    1993-03-01

    This report presents the results of an aggregate area management study (AAMS) for the PUREX Plant Aggregate Area in the 200 Areas of the US Department of Energy (DOE)Hanford Site in Washington State. This scoping level study provides the basis for initiating Remedial Investigation/Feasibility Study (RI/FS) activities under the comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) or Resource Conservation and Recovery Act (RCRA) Facility Investigations (RFI) and Corrective Measures Studies (CMS) under RCRA. This report also integrates select RCRA treatment, storage, or disposal (TSD) closure activities with CERCLA and RCRA past-practice investigations

  17. 90% Compliance Pilot Studies Final Report

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-01

    In early 2010, the U.S. Department of Energy (DOE) announced an opportunity for states to participate in energy code compliance evaluation pilot studies. DOE worked with five Regional Energy Efficiency Organizations (REEOs, formerly referred to as Energy Efficiency Partnerships, or EEPs) to fund pilot studies covering nine states. This report details conclusions stated in individual state reports, as well as conclusions drawn by DOE based on their oversight of the pilot studies, and based on discussions held with the REEOs and representatives from the pilot study states and their contractors.

  18. Thermal regulation of functional groups in running water ecosystems. Progress report, October 1, 1975--June 30, 1976

    Energy Technology Data Exchange (ETDEWEB)

    Cummins, K.W.; Klug, M.J.

    1976-07-01

    Progress is reported on the following research projects: characterization of functional groups of running water organisms, particularly macroconsumers; studies on relationship of functional groups to qualitative and quantitative characteristics of organic inputs to stream ecosystems; studies on relationship of functional groups to thermal regimes; and dimensioning the control of feeding and growth by temperature and food quality and quantity and determining the extent of compensatory action of each. (HLW)

  19. Cooper Drive pedestrian study : final report.

    Science.gov (United States)

    2006-07-01

    The purpose of this report is to summarize the findings of the pedestrian study conducted for Cooper Drive from Nicholasville Road to Sports Center Drive on the University of Kentucky Campus in Lexington, KY. This study was initiated by the Universit...

  20. Summary reports for key Hoodia clinical studies

    CSIR Research Space (South Africa)

    Maharaj, VJ

    2011-12-01

    Full Text Available The CSIR has acquired the reports to 14 clinical studies in which Hoodia has been assesses, using crude extracts and concentrated active ingredients formulated in a number of different ways. In many of the studies Hoodia was found to be generally...

  1. Kidney function in obese adolescents with or without metabolic syndrome in a nationally-representative sample of pediatric population: First report from the Middle East and North Africa: The CASPIAN-III Study

    Directory of Open Access Journals (Sweden)

    Roya Kelishadi

    2013-01-01

    Full Text Available Background : Obesity in accordance with metabolic syndrome (MetS confronts populations at the higher risk of morbidity and mortality of chronic diseases including, chronic kidney diseases (CKD. The renal complication of obesity and MetS has been less debated in young adolescents. The objective of this study was to assess the kidney function in obese adolescents with or without MetS. Materials and Methods: The data used in this study were collected as part of a national study entitled Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable disease Study. The present study was conducted on a sub-sample of 113 obese adolescents (body mass index >95 th percentile aged between 10 years and 16 years selected by convenient sampling from the whole population studied. Anthropometric indexes and blood pressure were examined. A 12-h fasting serum was obtained for each participant to measure blood glucose, lipid profile, quantitative C-reactive protein (hs-CRP, Cystatin-c, urea, and creatinine. Fasting spot urine was collected to determine microalbumin and creatinine. Based on the study findings, participants were assigned into two groups with and without MetS. Results: The mean of microalbuminuria was in similar ranges in two groups and while the mean glomerular filtration rate (GFR calculated by Bokenkamp′s, updated and combined Schwartz′s formulas were significantly lower in MetS + obese group in comparison with obese group. The similar result was not achieved by Filler′s formula. Among MetS components, waist circumference had a correlation with hs-CRP ( P = 0.04; r = 0.15. GFR was calculated based on the Schwartz formula and Cystatin-c formulas had no significant correlation with any MetS components. Conclusion: Our findings suggest that MetS can increase the risk of kidney dysfunction in obese adolescents. More studies are suggested in this regard in the pediatric population.

  2. Self-Reported Executive Functioning in Everyday Life in Parkinson's Disease after Three Months of Subthalamic Deep Brain Stimulation.

    Science.gov (United States)

    Pham, Uyen Ha Gia; Andersson, Stein; Toft, Mathias; Pripp, Are Hugo; Konglund, Ane Eidahl; Dietrichs, Espen; Malt, Ulrik Fredrik; Skogseid, Inger Marie; Haraldsen, Ira Ronit Hebolt; Solbakk, Anne-Kristin

    2015-01-01

    Objective. Studies on the effect of subthalamic deep brain stimulation (STN-DBS) on executive functioning in Parkinson's disease (PD) are still controversial. In this study we compared self-reported daily executive functioning in PD patients before and after three months of STN-DBS. We also examined whether executive functioning in everyday life was associated with motor symptoms, apathy, and psychiatric symptoms. Method. 40 PD patients were examined with the Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A), the Symptom Checklist 90-Revised (SCL-90-R), and the Apathy Evaluation Scale (AES-S). Results. PD patients reported significant improvement in daily life executive functioning after 3 months of STN-DBS. Anxiety scores significantly declined, while other psychiatric symptoms remained unchanged. The improvement of self-reported executive functioning did not correlate with motor improvement after STN-DBS. Apathy scores remained unchanged after surgery. Only preoperative depressed mood had predictive value to the improvement of executive function and appears to prevent potentially favorable outcomes from STN-DBS on some aspects of executive function. Conclusion. PD patients being screened for STN-DBS surgery should be evaluated with regard to self-reported executive functioning. Depressive symptoms in presurgical PD patients should be treated. Complementary information about daily life executive functioning in PD patients might enhance further treatment planning of STN-DBS.

  3. Functional Capacity Evaluation Research : Report from the Third International Functional Capacity Evaluation Research Meeting

    NARCIS (Netherlands)

    James, C. L.; Reneman, M. F.; Gross, D. P.

    Introduction Functional capacity evaluations are an important component of many occupational rehabilitation programs and can play a role in facilitating reintegration to work thus improving health and disability outcomes. The field of functional capacity evaluation (FCE) research has continued to

  4. To see bruxism: a functional MRI study.

    Science.gov (United States)

    Yılmaz, S

    2015-01-01

    Since the pathophysiology of bruxism is not clearly understood, there exists no possible treatment. The aim of this study is to investigate the cerebral activation differences between healthy subjects and patients with bruxism on behalf of possible aetiological factors. 12 healthy subjects and 12 patients with bruxism, a total of 24 right-handed female subjects (aged 20-27 years) were examined using functional MRI during tooth-clenching and resting tasks. Imaging was performed with 3.0-T MRI scanner with a 32-channel head coil. Differences in regional brain activity between patients with bruxism and healthy subjects (control group) were observed with BrainVoyager QX 2.8 (Brain Innovation, Maastricht, Netherlands) statistical data analysis program. Activation maps were created using the general linear model: single study and multistudy multisubject for statistical group analysis. This protocol was approved by the ethics committee of medical faculty of Kirikkale University, Turkey (02/04), based on the guidelines set forth in the Declaration of Helsinki. The group analysis revealed a statistically significant increase in blood oxygenation level-dependent signal of three clusters in the control group (pbruxism. Our findings indicate that there was a decrease of cortical activation pattern in patients with bruxism in clenching tasks. This indicates decreased blood flow and activation in regional neuronal activity. Bruxism, as an oral motor disorder concerns dentistry, neurology and psychiatry. These results might improve the understanding and physiological handling of sleep bruxism.

  5. Development and Validation of a Self-Report Measure of Mentalizing: The Reflective Functioning Questionnaire.

    Directory of Open Access Journals (Sweden)

    Peter Fonagy

    Full Text Available Reflective functioning or mentalizing is the capacity to interpret both the self and others in terms of internal mental states such as feelings, wishes, goals, desires, and attitudes. This paper is part of a series of papers outlining the development and psychometric features of a new self-report measure, the Reflective Functioning Questionnaire (RFQ, designed to provide an easy to administer self-report measure of mentalizing. We describe the development and initial validation of the RFQ in three studies. Study 1 focuses on the development of the RFQ, its factor structure and construct validity in a sample of patients with Borderline Personality Disorder (BPD and Eating Disorder (ED (n = 108 and normal controls (n = 295. Study 2 aims to replicate these findings in a fresh sample of 129 patients with personality disorder and 281 normal controls. Study 3 addresses the relationship between the RFQ, parental reflective functioning and infant attachment status as assessed with the Strange Situation Procedure (SSP in a sample of 136 community mothers and their infants. In both Study 1 and 2, confirmatory factor analyses yielded two factors assessing Certainty (RFQ_C and Uncertainty (RFQ_U about the mental states of self and others. These two factors were relatively distinct, invariant across clinical and non-clinical samples, had satisfactory internal consistency and test-retest stability, and were largely unrelated to demographic features. The scales discriminated between patients and controls, and were significantly and in theoretically predicted ways correlated with measures of empathy, mindfulness and perspective-taking, and with both self-reported and clinician-reported measures of borderline personality features and other indices of maladaptive personality functioning. Furthermore, the RFQ scales were associated with levels of parental reflective functioning, which in turn predicted infant attachment status in the SSP. Overall, this study lends

  6. Vadose Zone Transport Field Study: Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Ward, Andy L.; Conrad, Mark E.; Daily, William D.; Fink, James B.; Freedman, Vicky L.; Gee, Glendon W.; Hoversten, Gary M.; Keller, Jason M.; Majer, Ernest L.; Murray, Christopher J.; White, Mark D.; Yabusaki, Steven B.; Zhang, Z. F.

    2006-07-31

    migration (e.g. BC Cribs and Trenches). The improved models have been also coupled with inverse models and newly-developed parameter scaling techniques to allow estimation of field-scale and effective transport parameters for the vadose zone. The development and utility of pedotransfer functions for describing fine-scale hydrogeochemical heterogeneity and for incorporating this heterogeneity into reactive transport models was explored. An approach based on grain-size statistics appears feasible and has been used to describe heterogeneity in hydraulic properties and sorption properties, such as the cation exchange capacity and the specific surface area of Hanford sediments. This work has also led to the development of inverse modeling capabilities for time-dependent, subsurface, reactive transport with transient flow fields using an automated optimization algorithm. In addition, a number of geophysical techniques investigated for their potential to provide detailed information on the subtle changes in lithology and bedding surfaces; plume delineation, leak detection. High-resolution resistivity is now being used for detecting saline plumes at several waste sites at Hanford, including tank farms. Results from the field studies and associated analysis have appeared in more than 46 publications generated over the past 4 years. These publications include test plans and status reports, in addition to numerous technical notes and peer reviewed papers.

  7. General report of the Insurance Study Committee

    International Nuclear Information System (INIS)

    1988-01-01

    This general report gives the main objectives which the Insurance Study Committee intends to follow, an overview of the work undertaken from 1985-1988 and some points that the Committee considers its duty to underline, propose or recommend in the field of risk management. It concludes with the report of the Group of Experts on Third Party Liability and Nuclear Insurance, set up in 1986 to study and prepare the position to be taken by UNIPEDE on nuclear third party liability matters at the Group of Governmental Experts on Nuclear Third Party Liability and at the IAEA Standing Committee on Civil Liability for Nuclear Damage [fr

  8. Renal Function Studies with a Scintillation Camera

    Energy Technology Data Exchange (ETDEWEB)

    Farmelant, M. H.; Genna, S.; Burrows, B. A. [University Hospital and Boston Veterans Administration Hospital, Boston, MA (United States)

    1969-05-15

    Renal function studies with {sup 131}I-Hippuran have usually been performed with two probes, with flat field collimators, of which the sensitivity is dependent on kidney position. Although a variety of methods have been used to interpret the results, it is almost universally agreed that the relative magnitudes of the curves obtained during the accumulation phase are determined by both the relative blood flow and relative geometrical efficiency of counting. The relative influence of these two factors is not easily ascertained. Because of this limitation in directly assessing relative renal blood flow indirect methods have evolved. From physiological studies in dogs it appears that differences between the kidneys in blood flow produce differences in renal passage time and subsequently differences in the descending portions of the curves. Evaluation of differences in the descending curves in patients has proved highly sensitive in detecting renal vascular disease causing hypertension. However, obstructive disorders of urine outflow also produce alterations in the declining portion of the curve. A scintillation camera provides a detector considerably larger than the kidney and uses parallel hole collimation. This arrangement results in count-rates that are largely independent of kidney position, as shown by phantom studies. Furthermore, sequential scintigraphs can be obtained. Using the Pho-Gamma III (Nuclear Chicago) with 'split' crystal for clinical studies, we have demonstrated that the relative uptake of {sup 131}I-Hippuran by the two kidneys during the accumulation phase differs by less than 15% in normal people. These differences may be related to differences in kidney size or blood flow. Differences greater than this suggest significant differences between the kidneys in renal blood flow if the scintigrams show kidneys of comparable size. The sequential scintigrams have proven to be accurate in differentiating retention of radioisotope due to vascular disease

  9. Profile of Self-Reported Problems with Executive Functioning in College and Professional Football Players

    Science.gov (United States)

    Seichepine, Daniel R.; Stamm, Julie M.; Daneshvar, Daniel H.; Riley, David O.; Baugh, Christine M.; Gavett, Brandon E.; Tripodis, Yorghos; Martin, Brett; Chaisson, Christine; McKee, Ann C.; Cantu, Robert C.; Nowinski, Christopher J.

    2013-01-01

    Abstract Repetitive mild traumatic brain injury (mTBI), such as that experienced by contact-sport athletes, has been associated with the development of chronic traumatic encephalopathy (CTE). Executive dysfunction is believed to be among the earliest symptoms of CTE, with these symptoms presenting in the fourth or fifth decade of life. The present study used a well-validated self-report measure to study executive functioning in football players, compared to healthy adults. Sixty-four college and professional football players were administered the Behavior Rating Inventory of Executive Function, adult version (BRIEF-A) to evaluate nine areas of executive functioning. Scores on the BRIEF-A were compared to published age-corrected normative scores for healthy adults Relative to healthy adults, the football players indicated significantly more problems overall and on seven of the nine clinical scales, including Inhibit, Shift, Emotional Control, Initiate, Working Memory, Plan/Organize, and Task Monitor. These symptoms were greater in athletes 40 and older, relative to younger players. In sum, football players reported more-frequent problems with executive functioning and these symptoms may develop or worsen in the fifth decade of life. The findings are in accord with a growing body of evidence that participation in football is associated with the development of cognitive changes and dementia as observed in CTE. PMID:23421745

  10. Profile of self-reported problems with executive functioning in college and professional football players.

    Science.gov (United States)

    Seichepine, Daniel R; Stamm, Julie M; Daneshvar, Daniel H; Riley, David O; Baugh, Christine M; Gavett, Brandon E; Tripodis, Yorghos; Martin, Brett; Chaisson, Christine; McKee, Ann C; Cantu, Robert C; Nowinski, Christopher J; Stern, Robert A

    2013-07-15

    Repetitive mild traumatic brain injury (mTBI), such as that experienced by contact-sport athletes, has been associated with the development of chronic traumatic encephalopathy (CTE). Executive dysfunction is believed to be among the earliest symptoms of CTE, with these symptoms presenting in the fourth or fifth decade of life. The present study used a well-validated self-report measure to study executive functioning in football players, compared to healthy adults. Sixty-four college and professional football players were administered the Behavior Rating Inventory of Executive Function, adult version (BRIEF-A) to evaluate nine areas of executive functioning. Scores on the BRIEF-A were compared to published age-corrected normative scores for healthy adults Relative to healthy adults, the football players indicated significantly more problems overall and on seven of the nine clinical scales, including Inhibit, Shift, Emotional Control, Initiate, Working Memory, Plan/Organize, and Task Monitor. These symptoms were greater in athletes 40 and older, relative to younger players. In sum, football players reported more-frequent problems with executive functioning and these symptoms may develop or worsen in the fifth decade of life. The findings are in accord with a growing body of evidence that participation in football is associated with the development of cognitive changes and dementia as observed in CTE.

  11. NCSS Peace Studies Project: An Interim Report.

    Science.gov (United States)

    Ferber, Michael

    This preliminary report of a National Council for the Social Studies (NCSS) project briefly assesses teaching materials related to peace and nuclear warfare. Covering elementary, secondary, and higher education, the materials discussed present a variety of activities, decision-making approaches, and analytical assessments of policies of many…

  12. Dam water quality study. Report to Congress

    International Nuclear Information System (INIS)

    1989-05-01

    The objective of the report is to identify water quality effects attributable to the impoundment of water by dams as required by Section 524 of the Water Quality Act of 1987. The document presents a study of water quality effects associated with impoundments in the U.S.A

  13. Bus safety study : a report to Congress.

    Science.gov (United States)

    2013-11-01

    Section 20021(b) of the Moving Ahead for Progress for the 21st Century (MAP-21) legislation requires the Secretary of Transportation : to submit a report of the results of a Bus Safety Study to the Committee on Banking, Housing, and Urban Affai...

  14. Geothermal reservoir insurance study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-09

    The principal goal of this study was to provide analysis of and recommendations on the need for and feasibility of a geothermal reservoir insurance program. Five major tasks are reported: perception of risk by major market sectors, status of private sector insurance programs, analysis of reservoir risks, alternative government roles, and recommendations.

  15. Canister storage building trade study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Swenson, C.E. [Westinghouse Hanford Co., Richland, WA (United States)

    1995-05-01

    This study was performed to evaluate the impact of several technical issues related to the usage of the Canister Storage Building (CSB) to safely stage and store N-Reactor spent fuel currently located at K-Basin 100KW and 100KE. Each technical issue formed the basis for an individual trade study used to develop the ROM cost and schedule estimates. The study used concept 2D from the Fluor prepared ``Staging and Storage Facility (SSF) Feasibility Report`` as the basis for development of the individual trade studies.

  16. Canister storage building trade study. Final report

    International Nuclear Information System (INIS)

    Swenson, C.E.

    1995-05-01

    This study was performed to evaluate the impact of several technical issues related to the usage of the Canister Storage Building (CSB) to safely stage and store N-Reactor spent fuel currently located at K-Basin 100KW and 100KE. Each technical issue formed the basis for an individual trade study used to develop the ROM cost and schedule estimates. The study used concept 2D from the Fluor prepared ''Staging and Storage Facility (SSF) Feasibility Report'' as the basis for development of the individual trade studies

  17. Supplementary report: millimeter wave study program

    International Nuclear Information System (INIS)

    Jory, H.R.; Symons, R.S.

    1976-02-01

    This report describes work done during the months of December 1975 and January 1976, following the writing of the final report on the millimeter wave study program for generation of 100 kW or more power at 120 GHz. The work has been directed to three areas for application to gyrotron devices, small signal analysis, electron beam simulation, and microwave measurements on cavity coupling. A small signal analysis is presented, which allows determination of beam loading in cavities. The results are similar to previous published work, but contain a higher order relativistic correction. The electron beam simulations include two magnetron type guns and one based on electrostatic lenses

  18. Recommendations and final report on the Alberta transmission administrator function

    International Nuclear Information System (INIS)

    Billinton, R.; Wallace, R.B.

    1997-01-01

    In May 1995, the Electric Utilities Act (EUA) was passed formalizing the Alberta government's policy of electric industry restructuring. The Act established two new important market entities: a power pool and a transmission administrator (TA). Combined, these two entities create the open access required to enable competition in generation. Functionally, the TA acts as a single transmission service agent for all transmission wire owners. The TA leases the wires from owners then provides a province-wide tariff schedule for transmission services to recover the required revenue. Customers can only purchase transmission service from the TA. Both the lease wire cost and the TA tariff schedule must be approved by the regulator

  19. SPEAR-FCODE-GAMMA functional specifications. Final report

    International Nuclear Information System (INIS)

    Fiero, I.B.

    1983-03-01

    SPEAR FCODE GAMMA (SFG), a conceptual fuel-performance code for use in licensing analyses, has been defined and characterized as a set of functional specifications. The potential licensing-related applications of SFG are established and discussed. General code specifications including regulatory, interface, hardware application, code model and software, and operational specifications are discussed. The code input and output information including data requirements as well as formatting aspects are detailed. Finally, the SFG code-accuracy guidelines are established and the validation process is described

  20. Self-reported Physical Activity Predicts Pain Inhibitory and Facilitatory Function

    Science.gov (United States)

    Naugle, Kelly M.; Riley, Joseph L.

    2013-01-01

    Considerable evidence suggests regular physical activity can reduce chronic pain symptoms. Dysfunction of endogenous facilitatory and inhibitory systems has been implicated in multiple chronic pain conditions. However, few studies have investigated the relationship between levels of physical activity and descending pain modulatory function. Purpose This study’s purpose was to determine whether self-reported levels of physical activity in healthy adults predicted 1) pain sensitivity to heat and cold stimuli, 2) pain facilitatory function as tested by temporal summation of pain (TS), and 3) pain inhibitory function as tested by conditioned pain modulation (CPM) and offset analgesia. Methods Forty-eight healthy adults (age range 18–76) completed the International Physical Activity Questionnaire (IPAQ) and the following pain tests: heat pain thresholds (HPT), heat pain suprathresholds, cold pressor pain (CPP), temporal summation of heat pain, conditioned pain modulation, and offset analgesia. The IPAQ measured levels of walking, moderate, vigorous and total physical activity over the past seven days. Hierarchical linear regressions were conducted to determine the relationship between each pain test and self-reported levels of physical activity, while controlling for age, sex and psychological variables. Results Self-reported total and vigorous physical activity predicted TS and CPM (p’s pain and greater CPM. The IPAQ measures did not predict any of the other pain measures. Conclusion Thus, these results suggest that healthy older and younger adults who self-report greater levels of vigorous and total physical activity exhibit enhanced descending pain modulatory function. Improved descending pain modulation may be a mechanism through which exercise reduces or prevents chronic pain symptoms. PMID:23899890

  1. Genesee River Basin Study; Reconnaissance Report. Volume 1. Main Report.

    Science.gov (United States)

    1986-01-01

    River in the Towns of Chili and Riga, Monroe County, New York" was prepared in September 1969. The report gives a history of flooding and outlines...a benefit - cost ratio of less than unity. 9 A report entitled "Flood Recovery Planning Program - Preliminary Evaluation of Stony Brook and Mill Creek...Creek, Town ot (a Chili , and Ogden, Monroe County, New York," was prepared in August 1915. Ttl- report presents a brief history of flooding and

  2. Liver Function Study using {sup 131}I-BSP

    Energy Technology Data Exchange (ETDEWEB)

    Yamada, Hideo; Lio, Masahiro; Chibe, Kazuo; Kameda, Haruo; Ueda, Hideo [Tokyo University Hospital, Tokyo (Japan); Luchi, Masahiko; Ishiwa, Mamoru [Kofu Municipal Hospital, Kofu (Japan)

    1971-03-15

    Liver function tests are indispensable for diagnosis of liver diseases. It is desirable to conduct several kinds of test for over-all evaluation of liver function, considering the various aspects of metabolism performed in the liver. Diagnosis of the existence and severity of liver diseases, especially in cases without jaundice and judgment of prognosis and effects of treatment must be made by various liver function tests. So far, the BSP loading test has been widely used as the most sensitive index of liver function, since BSP greatly contributes to the diagnosis of liver disease without jaundice and evaluation of prognosis. However, the clinical use of the BSP test seems to be decreasing, because side effects, such as pain and anaphylaxis-like shock, occasionally causing death, have been reported (1). Indocyanine-Green (ICG) appears to be replacing the BSP test as a safer dye for the dye excretion test (2,3), but it has not yet been widely used for clinical purpose because of problems of product stability and measurement procedures. The authors previously used {sup 35}S-BSP to analyze the mechanism of liver uptake of the dye and determined maximum hepatic uptake capacity of BSP in normal controls and for various liver diseases (4). At the same time it was noted that, in the presence of function disturbance, the liver cannot adequately handle even a tracer dose of BSP, and blood clearance of a tracer dose of BSP is not exclusively dependent on hepatic blood flow, but is also dependent on the hepatocellular function of dye uptake (5). BSP and ICG have been also used as a bilirubin analogue for analysis of clearance after a single intravenous injection (6) and to biliary excretion of the dye under continuous infusion in normal subjects as well as in various liver diseases (7). A clinical test must be safe and simple for routine use. The measurement of {sup 35}S-BSP is rather complicated while {sup 131}I-BSP, the basic properties of which were intensively studied (8

  3. Functional MRI studies of human vision on a clinical imager

    International Nuclear Information System (INIS)

    George, J.S.; Lewine, J.D.; Aine, C.J.; van Hulsteyn, D.; Wood, C.C.; Sanders, J.; Maclin, E.; Belliveau, J.W.; Caprihan, A.

    1992-01-01

    During the past decade, Magnetic Resonance Imaging (MRI) has become the method of choice for imaging the anatomy of the human brain. Recently, Belliveau and colleagues have reported the use of echo planar magnetic resonance imaging (EPI) to image patterns of neural activity. Here, we report functional MR imaging in response to visual stimulation without the use of contrast agents, and without the extensive hardware modifications required for EPI. Regions of activity were observed near the expected locations of V1, V2 and possibly V3 and another active region was observed near the parietal-occipital sulcus on the superior surface of the cerebrum. These locations are consistent with sources observed in neuromagnetic studies of the human visual response

  4. Hypoactive medial prefrontal cortex functioning in adults reporting childhood emotional maltreatment.

    Science.gov (United States)

    van Harmelen, Anne-Laura; van Tol, Marie-José; Dalgleish, Tim; van der Wee, Nic J A; Veltman, Dick J; Aleman, André; Spinhoven, Philip; Penninx, Brenda W J H; Elzinga, Bernet M

    2014-12-01

    Childhood emotional maltreatment (CEM) has adverse effects on medial prefrontal cortex (mPFC) morphology, a structure that is crucial for cognitive functioning and (emotional) memory and which modulates the limbic system. In addition, CEM has been linked to amygdala hyperactivity during emotional face processing. However, no study has yet investigated the functional neural correlates of neutral and emotional memory in adults reporting CEM. Using functional magnetic resonance imaging, we investigated CEM-related differential activations in mPFC during the encoding and recognition of positive, negative and neutral words. The sample (N = 194) consisted of patients with depression and/or anxiety disorders and healthy controls (HC) reporting CEM (n = 96) and patients and HC reporting no abuse (n = 98). We found a consistent pattern of mPFC hypoactivation during encoding and recognition of positive, negative and neutral words in individuals reporting CEM. These results were not explained by psychopathology or severity of depression or anxiety symptoms, or by gender, level of neuroticism, parental psychopathology, negative life events, antidepressant use or decreased mPFC volume in the CEM group. These findings indicate mPFC hypoactivity in individuals reporting CEM during emotional and neutral memory encoding and recognition. Our findings suggest that CEM may increase individuals' risk to the development of psychopathology on differential levels of processing in the brain; blunted mPFC activation during higher order processing and enhanced amygdala activation during automatic/lower order emotion processing. These findings are vital in understanding the long-term consequences of CEM. © The Author (2014). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

  5. The functions of language: an experimental study.

    Science.gov (United States)

    Redhead, Gina; Dunbar, R I M

    2013-08-14

    We test between four separate hypotheses (social gossip, social contracts, mate advertising and factual information exchange) for the function(s) of language using a recall paradigm. Subjects recalled the social content of stories (irrespective of whether this concerned social behavior, defection or romantic events) significantly better than they did ecological information. Recall rates were no better on ecological stories if they involved flamboyant language, suggesting that, if true, Miller's "Scheherazade effect" may not be independent of content. One interpretation of these results might be that language evolved as an all-purpose social tool, and perhaps acquired specialist functions (sexual advertising, contract formation, information exchange) at a later date through conventional evolutionary windows of opportunity.

  6. The Functions of Language: An Experimental Study

    Directory of Open Access Journals (Sweden)

    Gina Redhead

    2013-10-01

    Full Text Available We test between four separate hypotheses (social gossip, social contracts, mate advertising and factual information exchange for the function(s of language using a recall paradigm. Subjects recalled the social content of stories (irrespective of whether this concerned social behavior, defection or romantic events significantly better than they did ecological information. Recall rates were no better on ecological stories if they involved flamboyant language, suggesting that, if true, Miller's “Scheherazade effect” may not be independent of content. One interpretation of these results might be that language evolved as an all-purpose social tool, and perhaps acquired specialist functions (sexual advertising, contract formation, information exchange at a later date through conventional evolutionary windows of opportunity.

  7. Biospecimen Reporting for Improved Study Quality (BRISQ)

    Energy Technology Data Exchange (ETDEWEB)

    National Cancer Institute; Jewell, Ph.D., Scott D.; Seijo, M.S., Edward; Kelly, Ph.D., Andrea; Somiari, Ph.D., Stella; B.Chir., M.B.; McShane, Ph.D., Lisa M.; Clark, M.D., Douglas; Greenspan, M.D., Renata; Hayes, M.D., Daniel F.; Hainaut, Ph.D., M.S., Pierre; Kim, Paula; Mansfield, Ph.D., Elizabeth; Potapova, Ph.D., Olga; Riegman, Ph.D., Peter; Rubinstein, Ph.D., Yaffa; Weier, Ph.D., Heinz-Ulrich; Zhu, Ph.D., Claire; Moore, Ph.D., Helen M.; Vaught, Ph.D., Jim; Watson, Peter

    2010-09-02

    Human biospecimens are subjected to collection, processing, and storage that can significantly alter their molecular composition and consistency. These biospecimen preanalytical factors, in turn, influence experimental outcomes and the ability to reproduce scientific results. Currently, the extent and type of information specific to the biospecimen preanalytical conditions reported in scientific publications and regulatory submissions varies widely. To improve the quality of research that uses human tissues, it is crucial that information on the handling of biospecimens be reported in a thorough, accurate, and standardized manner. The Biospecimen Reporting for Improved Study Quality (BRISQ) recommendations outlined herein are intended to apply to any study in which human biospecimens are used. The purpose of reporting these details is to supply others, from researchers to regulators, with more consistent and standardized information to better evaluate, interpret, compare, and reproduce the experimental results. The BRISQ guidelines are proposed as an important and timely resource tool to strengthen communication and publications on biospecimen-related research and to help reassure patient contributors and the advocacy community that their contributions are valued and respected.

  8. Biospecimen Reporting for Improved Study Quality

    Energy Technology Data Exchange (ETDEWEB)

    Moore, Ph.D., Helen M.; Kelly, Ph.D., Andrea B.; Jewell, Ph.D., Scott D.; McShane, Ph.D., Lisa M.; Clark, M.D., Douglas P.; Greenspan, M.D., Renata; Hayes, M.D., Daniel F.; Hainaut, Ph.D., Pierre; Kim, Paula; Mansfield, Ph.D., Elizabeth A.; Potapova, Ph.D., Olga; Riegman, Ph.D., Peter; Rubinstein, Ph.D., Yaffa; Seijo, M.S., Edward; Somiari, Ph.D., Stella; Chir., B; Weier, Ph.D., Heinz-Ulrich; Zhu, Ph.D., Claire; Vaught, Ph.D., Jim; Watson,M.B., Peter

    2010-12-27

    Human biospecimens are subjected to collection, processing, and storage that can significantly alter their molecular composition and consistency. These biospecimen preanalytical factors, in turn, influence experimental outcomes and the ability to reproduce scientific results. Currently, the extent and type of information specific to the biospecimen preanalytical conditions reported in scientific publications and regulatory submissions varies widely. To improve the quality of research that uses human tissues, it is crucial that information on the handling of biospecimens be reported in a thorough, accurate, and standardized manner. The Biospecimen Reporting for Improved Study Quality (BRISQ) recommendations outlined herein are intended to apply to any study in which human biospecimens are used. The purpose of reporting these details is to supply others, from researchers to regulators, with more consistent and standardized information to better evaluate, interpret, compare, and reproduce the experimental results. The BRISQ guidelines are proposed as an important and timely resource tool to strengthen communication and publications on biospecimen-related research and to help reassure patient contributors and the advocacy community that their contributions are valued and respected.

  9. Biospecimen Reporting for Improved Study Quality (BRISQ)

    Energy Technology Data Exchange (ETDEWEB)

    Moore, Ph.D., Helen M.; Kelly Ph.D., Andrea; Jewell Ph.D., Scott D.; McShane Ph.D., Lisa M.; Clark M.D., Douglas P.; Greenspan M.D., Renata; Hayes M.D., Daniel F.; Hainaut Ph.D.,, Pierre; Kim, Paula; Mansfield Ph.D., Elizabeth; Potapova Ph.D., Olga; Riegman Ph.D., Peter; Rubinstein Ph.D., Yaffa; Seijo M.S., Edward; Somiari Ph.D., Stella; Watson M.B., Peter; Weier Ph.D., Heinz-Ulrich; Zhu Ph.D., Claire; Vaught Ph.D., Jim

    2011-04-26

    Human biospecimens are subject to a number of different collection, processing, and storage factors that can significantly alter their molecular composition and consistency. These biospecimen preanalytical factors, in turn, influence experimental outcomes and the ability to reproduce scientific results. Currently, the extent and type of information specific to the biospecimen preanalytical conditions reported in scientific publications and regulatory submissions varies widely. To improve the quality of research utilizing human tissues it is critical that information regarding the handling of biospecimens be reported in a thorough, accurate, and standardized manner. The Biospecimen Reporting for Improved Study Quality (BRISQ) recommendations outlined herein are intended to apply to any study in which human biospecimens are used. The purpose of reporting these details is to supply others, from researchers to regulators, with more consistent and standardized information to better evaluate, interpret, compare, and reproduce the experimental results. The BRISQ guidelines are proposed as an important and timely resource tool to strengthen communication and publications around biospecimen-related research and help reassure patient contributors and the advocacy community that the contributions are valued and respected.

  10. Electroceramic functional gradient materials. Final report 1995 - 1998

    Energy Technology Data Exchange (ETDEWEB)

    Toft Soerensen, O. [ed.

    1999-10-01

    In this programme the research and development is focused on electroceramic materials, which are of direct interest for the Danish producers of electronic components (AMP Danmark) and ceramic gas sensors (PBI-Dansensor) as well as companies involved in development of fuel cells (Haldor Topsoee). The R and D work has been focused on strategic materials research, both application oriented and more basic research, and on development of new techniques for fabrication of EFGM (Electroceramic Functional Gradient Materials) of three types: LC circuit materials (electronic noise filters), oxides for electrochemical reactors and solid oxide fuel cell applications (SOFC) and materials (semiconductors, oxygen ion conductors) for oxygen sensors. This work has been carried out in five projects: 1) Integrated filter components; 2) Electrochemical reactor materials; 3) Oxygen sensors based on semiconductors and oxygen ion conductors; 4) Interface models - synthesis and characterisation; 5) Suppression of cracking in multilayered ceramic materials. (EHS)

  11. Orthodontic management by functional activator treatment: a case report.

    Science.gov (United States)

    Aprile, Giuseppe; Ortu, Eleonora; Cattaneo, Ruggero; Pietropaoli, Davide; Giannoni, Mario; Monaco, Annalisa

    2017-12-02

    Managing orthodontic treatment is often very difficult for the orthodontist. Many devices are used during the orthopedic phase of orthodontic treatment, always with different functions. We describe a case of orthodontic management treated with the Equilibrator O.S.A. device (equilibrator designed by Ovidi, Santi, and Aprile for Eptamed SRL; Cesena, Italy; www.eptamed.com ). A healthy 10-year-old white boy presented with a skeletal class II, division 1 malocclusion, molar class II, exhibiting an overjet of 7 mm prior to treatment. For treatment, we only used the Equilibrator O.S.A. device. We successfully treated an orthopedic/orthodontic case with a particular device that we describe here.

  12. Report on Adaptive Force, a specific neuromuscular function

    Directory of Open Access Journals (Sweden)

    Marko Hoff

    2015-08-01

    Full Text Available In real life motions, as well as in sports, the adaptation of the neuromuscular systems to externally applied forces plays an important role. The term Adaptive Force (AF shall characterize the ability of the nerve-muscle-system to adapt to impacting external forces during isometric and eccentric muscle action. The focus in this paper is on the concept of this neuromuscular action, which is not yet described in this way. A measuring system was constructed and evaluated for this specific neuromuscular function, but only the main information of the evaluation of the measuring system and the preliminary reference values are mentioned here, while an article with detailed description will be published separately. This paper concentrates on the three following points: 1 What is the peculiarity of this neuromuscular function, introduced as AF? 2 Is the measuring system able to capture its specific characteristics and which phases of measurement occur? 3 It seems reasonable to discuss if AF can be distinguished and classified among the known force concepts. The article describes the measuring system and how it is able to capture special features of real life motions like submaximal intensities and the subjects’ option to react adequately on external varying forces. Furthermore, within one measurement the system records three different force qualities: the isometric submaximal Adaptive Force (AFiso, the maximal isometric Adaptive Force (AFisomax and the maximal eccentric Adaptive Force (AFeccmax. Each of these phases provide different and unique information on the nerve-muscle-system that are discussed in detail. Important, in terms of the Adaptive Force, seems to be the combination of conditional and coordinative abilities.

  13. Initial report of the cancer Patient-Reported Outcomes Measurement Information System (PROMIS) sexual function committee: review of sexual function measures and domains used in oncology.

    Science.gov (United States)

    Jeffery, Diana D; Tzeng, Janice P; Keefe, Francis J; Porter, Laura S; Hahn, Elizabeth A; Flynn, Kathryn E; Reeve, Bryce B; Weinfurt, Kevin P

    2009-03-15

    For this report, the authors described the initial activities of the Cancer Patient-Reported Outcomes Measurement Information System (PROMIS)-Sexual Function domain group, which is part of the National Institutes of Health Roadmap Initiative to develop brief questionnaires or individually tailored assessments of quality-of-life domains. Presented are a literature review of sexual function measures used in cancer populations and descriptions of the domains found in those measures. By using a consensus-driven approach, an electronic bibliographic search was conducted for articles that were published from 1991 to 2007, and 486 articles were identified for in-depth review. In total, 257 articles reported the administration of a psychometrically evaluated sexual function measure to individuals who were diagnosed with cancer. Apart from the University of California-Los Angeles Prostate Cancer Index, the International Index of Erectile Function, and the Female Sexual Function Index, the 31 identified measures have not been tested widely in cancer populations. Most measures were multidimensional and included domains related to the sexual response cycle and to general sexual satisfaction. The current review supports the need for a flexible, psychometrically robust measure of sexual function for use in oncology settings and strongly justifies the development of the PROMIS-Sexual Function instrument. When the PROMIS-Sexual Function instrument is available publicly, cancer clinicians and researchers will have another measure with which to assess patient-reported sexual function outcomes in addition to the few legacy measures that were identified through this review. Copyright (c) 2009 American Cancer Society.

  14. Cardio-ankle vascular index is associated with cardiovascular target organ damage and vascular structure and function in patients with diabetes or metabolic syndrome, LOD-DIABETES study: a case series report.

    Science.gov (United States)

    Gómez-Marcos, Manuel Ángel; Recio-Rodríguez, José Ignacio; Patino-Alonso, María Carmen; Agudo-Conde, Cristina; Gómez-Sánchez, Leticia; Gomez-Sanchez, Marta; Rodríguez-Sanchez, Emiliano; Maderuelo-Fernandez, Jose Angel; García-Ortiz, Luís

    2015-01-16

    The cardio ankle vascular index (CAVI) is a new index of the overall stiffness of the artery from the origin of the aorta to the ankle. This index can estimate the risk of atherosclerosis. We aimed to find the relationship between CAVI and target organ damage (TOD), vascular structure and function, and cardiovascular risk factors in Caucasian patients with type 2 diabetes mellitus or metabolic syndrome. We included 110 subjects from the LOD-Diabetes study, whose mean age was 61 ± 11 years, and 37.3% were women. Measurements of CAVI, brachial ankle pulse wave velocity (ba-PWV), and ankle brachial index (ABI) were taken using the VaSera device. Cardiovascular risk factors, renal function by creatinine, glomerular filtration rate, and albumin creatinine index were also obtained, as well as cardiac TOD with ECG and vascular TOD and carotid intima media thickness (IMT), carotid femoral PWV (cf-PWV), and the central and peripheral augmentation index (CAIx and PAIx). The Framingham-D'Agostino scale was used to measure cardiovascular risk. Mean CAVI was 8.7 ± 1.3. More than half (54%) of the participants showed one or more TOD (10% cardiac, 13% renal; 48% vascular), and 13% had ba-PWV ≥ 17.5 m/s. Patients with any TOD had the highest CAVI values: 1.15 (CI 95% 0.70 to 1.61, p < 0.001) and 1.14 (CI 95% 0.68 to 1.60, p < 0.001) when vascular TOD was presented, and 1.30 (CI 95% 0.51 to 2.10, p = 0.002) for the cardiac TOD. The CAVI values had a positive correlation with HbA1c and systolic and diastolic blood pressure, and a negative correlation with waist circumference and body mass index. The positive correlations of CAVI with IMT (β = 0.29; p < 0.01), cf-PWV (β = 0.83; p < 0.01), ba-PWV (β = 2.12; p < 0.01), CAIx (β = 3.42; p < 0.01), and PAIx (β = 5.05; p = 0.04) remained after adjustment for cardiovascular risk, body mass index, and antihypertensive, lipid-lowering, and antidiabetic drugs. The

  15. Cement radwaste solidification studies third annual report

    International Nuclear Information System (INIS)

    Brown, D.J.; James, J.M.; Lee, D.J.; Smith, D.L.; Walker, A.T.

    1982-03-01

    This report summarises cement radwaste studies carried out at AEE Winfrith during 1981 on the encapsulation of medium and low active waste in cement. During the year more emphasis has been placed on the work which is directly related to the solidification of SGHWR active sludge. Information has been obtained on the properties of 220 dm 3 drums of cemented waste. The use of cement grouts for the encapsulation of solid items has also been investigated during 1981. (U.K.)

  16. Case Study Report about Gender Impact Assessment

    DEFF Research Database (Denmark)

    Faber, Stine Thidemann; Agustin, Lise Rolandsen

    2013-01-01

    The aim of this national case study report is to take a closer look at the use of Gender Impact Assessments in Denmark in order to describe the Danish implementation of this specific Gender Mainstreaming method. By way of analyzing two selected cases (two law proposals put forward by The Danish...... Ministry of Employment and the Danish Ministry of Transport, respectively) the aim is to assess the transformative potential of GIA as it is performed in Denmark....

  17. Physical protection equipment study. Final report

    International Nuclear Information System (INIS)

    Haberman, W.

    1977-06-01

    This report summarizes the work performed by MITRE for the U.S. Nuclear Regulatory Commission. The major products of this effort are a Catalog of Physical Protection Equipment, a Guide for Evaluation of Physical Protection Equipment, a book of Reference Materials, and a set of guidelines for use in the development of a methodology for measuring levels of security system effectiveness. A summary of recommendations resulting from this study is also presented

  18. Bioremediation case studies: Abstracts. Final report

    International Nuclear Information System (INIS)

    Devine, K.

    1992-03-01

    The report contains abstracts of 132 case studies of bioremediation technology applied to hazardous waste clean-up. It was prepared to compile bioremediation studies in a variety of locations and treating diverse contaminants, most of which were previously undocumented. All data are based on vendor-supplied information and there was no opportunity to independently confirm its accuracy. These 132 case studies, from 10 different biotechnology companies, provide users with reference information about on-going and/or completed field applications and studies. About two-thirds of the cases were at full-scale clean-up level with the remainder at pilot or laboratory scale. In 74 percent of the cases, soil was at least one of the media treated. Soil alone accounts for 46 percent of the cases. Petroleum-related wastes account for the largest contaminant with 82 cases. Thirty-one states are represented in the case studies

  19. Scanning the Global Environment. A framework and methodology for UNEP's reporting functions

    OpenAIRE

    Swart RJ; Bakkes JA; Niessen LW; Rotmans J; Vries HJM de; Weterings R; Rijksinstituut voor Volksgezondheid en Milieuhygiene RIVM; United Nations Environment Programme UNEP; MTV; ISC; VTV; CWM; SB4; TNO Centre for Technology and Policy Studies

    1994-01-01

    A conceptual framework for UNEP's reporting functions is proposed, aimed at supporting strategic environmental policy development. To this end information should be provided about the past, current and future state of the environment as a function of demographic and socio-economic developments. The policy relevance of the existing global environmental reporting functions may be improved considerably by introducing three new elements: (1) the application of integrated conceptual frameworks and...

  20. Canadian consumer battery baseline study : final report

    International Nuclear Information System (INIS)

    2007-02-01

    This report provided information about the estimated number of consumer and household batteries sold, re-used, stored, recycled, and disposed each year in Canada. The report discussed the ways in which different batteries posed risks to human health and the environment, and legislative trends were also reviewed. Data used in the report were obtained from a literature review as well as through a series of interviews. The study showed that alkaline batteries are the most common primary batteries used by Canadians, followed by zinc carbon batteries. However, lithium primary batteries are gaining in popularity, and silver oxide and zinc air button cell batteries are also used in applications requiring a flat voltage and high energy. Secondary batteries used in laptop computers, and cell phones are often made of nickel-cadmium, nickel-metal-hydroxide, and lithium ion. Small sealed lead batteries are also commonly used in emergency lighting and alarm systems. Annual consumption statistics for all types of batteries were provided. Results of the study showed that the primary battery market is expected to decline. Total units of secondary batteries are expected to increase to 38.6 million units by 2010. The report also used a spreadsheet model to estimate the flow of consumer batteries through the Canadian waste management system. An estimated 347 million consumer batteries were discarded in 2004. By 2010, it is expected that an estimated 494 million units will be discarded by consumers. The study also considered issues related to lead, cadmium, mercury, and nickel disposal and the potential for groundwater contamination. It was concluded that neither Canada nor its provinces or territories have initiated legislative or producer responsibility programs targeting primary or secondary consumer batteries. 79 refs., 37 tabs., 1 fig

  1. ACCOUNTING AND FINANCIAL REPORTS IN THE FUNCTION OF CORPORATE GOVERNANCE

    Directory of Open Access Journals (Sweden)

    Jugoslav Aničić

    2017-04-01

    Full Text Available Market economy development is highly dependent upon accounting data reliability and financial report quality because the investors decide more easily on investments in the market which had earned trust and safety in the previous period. Big financial scandals from the beginning of the 21st century and still actual financial crisis at the global level have especially contributed to that. The information prepared on the basis of high quality, transparent and comparable international standards considerably reduce investment risks as well as the cost of raising capital. On the other hand, the management of a large number of companies is focused on the creation of short-term personal benefits as opposed to the investors primarily interested in company survival and growth, that is, long-term goals. Information asymmetry is often present in the financial markets, and its damaging results, as a rule, are borne by shareholders and other stakeholders of the company. Corporate governance depends on legal, regulative and institutional environment, and it should balance the interests of the shareholders, capital owners, managers as well as company business managers.

  2. Fiscal 1993 technological survey report. R and D project for industrial science and technology (R and D of quantum functional device - studies on technological prediction); 1993 nendo ryoshi kino soshi no kenkyu kaihatsu (gijutsu yosoku kenkyu) seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-03-01

    Researches are in progress with a view to establishing fundamental technology for a quantum functional device, which engineeringly uses various quantum mechanical effects emerging in a ultrafine dimentional area, for the purpose of contributing to the micro electronics technology that deals with ultra high speed and ultra high functional information processing necessitated in an advanced information-oriented society. Survey on research activities was conducted concerning the peripheral technologies of a quantum functional device project, for example, related technologies such as a high temperature scanning tunneling microscope enabling preparation of a micro structure of nm order, and an ultra high vacuum CVD device. In addition, discussions were held on the subjects of preparation/evaluation technology of a quantum functional device and a single electronic device, with the purpose of predicting/judging, from a wider viewpoint, indications of unexpected research results of the R and D in the remarkably evolving field of quantum functional devices, quickly taking the indications into projects, and efficiently promoting the R and D by making sure of the directions to proceed. (NEDO)

  3. Sexual Functions in Obsessive Compulsive Disorder Patients: A Case Report

    Directory of Open Access Journals (Sweden)

    Nergis LAPSEKİLİ

    2012-11-01

    Full Text Available Introduction: Obsessive-compulsive disorder (OCD, even if the patient’s obsession content is not related to sexuality, may be a problem in the sexual lives of individuals. In this article, sexual function in obsessive compulsive disorder patients is discussed based on an OCD case. Case: Male 36 years old and female 32 years old couple. Man had complaints of lack of control of ejaculation and woman had complaints of lack of orgasm. Man was diagnosed with premature ejaculation and woman was diagnosed with aversion and anorgasmia according to DSM-IV (Diagnostic and Statistical Manual Of Mental Disorders criteria. During therapy, the female patient was diagnosed with OCD as well. Loss of control was not acceptable to the patient. Thus she was avoiding from exhilarating stimuli. After cognitive restructuring of her evaluations about control, sex therapy was continued. At the end of the therapy the avoidance of the patient disappeared and anorgasmia was treated and ejeculation time of the male patient was 15 minutes. Conclusion: Sexual dysfunction is a common problem in patients with OCD. Patient may have avoidance that may adversely affect her sexuality. If a patient has avoidance about sexuality, the reason of this avoidance may or may not be the usual and expected thought content like avoidance of contamination. The evaluations of OCD patients about control may also adversely affect their sexuallity. The thought leading to avoidance behavior, may vary from patient to patient. However, to identify these thoughts with cognitive interventions and work with them will improve.the patient.

  4. Spatial separation and bidirectional trafficking of proteins using a multi-functional reporter

    Directory of Open Access Journals (Sweden)

    Klaubert Dieter H

    2008-04-01

    Full Text Available Abstract Background The ability to specifically label proteins within living cells can provide information about their dynamics and function. To study a membrane protein, we fused a multi-functional reporter protein, HaloTag®, to the extracellular domain of a truncated integrin. Results Using the HaloTag technology, we could study the localization, trafficking and processing of an integrin-HaloTag fusion, which we showed had cellular dynamics consistent with native integrins. By labeling live cells with different fluorescent impermeable and permeable ligands, we showed spatial separation of plasma membrane and internal pools of the integrin-HaloTag fusion, and followed these protein pools over time to study bi-directional trafficking. In addition to combining the HaloTag reporter protein with different fluorophores, we also employed an affinity tag to achieve cell capture. Conclusion The HaloTag technology was used successfully to study expression, trafficking, spatial separation and real-time translocation of an integrin-HaloTag fusion, thereby demonstrating that this technology can be a powerful tool to investigate membrane protein biology in live cells.

  5. Self-reports of psychosocial functioning among children and young adults with cleft lip and palate.

    Science.gov (United States)

    Hunt, Orlagh; Burden, Donald; Hepper, Peter; Stevenson, Mike; Johnston, Chris

    2006-09-01

    A cross-sectional study was employed to determine the psychosocial effects of cleft lip and/or palate among children and young adults, compared with a control group of children and young adults without cleft lip and palate. The study comprised 160 children and young adults with cleft lip and/or palate and 113 children and young adults without cleft lip and/or palate. All participants were between 8 and 21 years of age. Psychological functioning (anxiety, self-esteem, depression, and behavioral problems) was assessed using validated psychological questionnaires. Happiness with facial appearance was rated using a visual analog scale. Social functioning, including experience of teasing/bullying and satisfaction with speech, was assessed using a semistructured interview. Participants with cleft lip and/or palate reported greater behavioral problems (p palate and subjects without cleft lip and/or palate in terms of anxiety (p > .05) or self-esteem (p > .05). Having been teased was a significant predictor of poor psychological functioning, more so than having a cleft lip and/or palate per se (p palate and it was a significant predictor of poorer psychosocial functioning. Children and young adults with cleft lip and/or palate require psychological assessment, specifically focusing on their experience of teasing, as part of their routine cleft care.

  6. Multi-informant reports of psychiatric symptoms among high-functioning adolescents with Asperger syndrome or autism.

    Science.gov (United States)

    Hurtig, Tuula; Kuusikko, Sanna; Mattila, Marja-Leena; Haapsamo, Helena; Ebeling, Hanna; Jussila, Katja; Joskitt, Leena; Pauls, David; Moilanen, Irma

    2009-11-01

    The aim of the study was to examine psychiatric symptoms in high-functioning adolescents with autism spectrum disorders reported by multiple informants. Forty-three 11- to 17-year-old adolescents with Asperger syndrome (AS) or high-functioning autism (HFA) and 217 typically developed adolescents completed the Youth Self-Report (YSR), while their parents completed the Child Behavior Checklist (CBCL). Teachers of adolescents with AS/HFA completed the Teacher Report Form (TRF). The informants reported significantly more psychiatric symptoms, especially withdrawn, anxious/depressed, social and attention problems, in adolescents with AS/HFA than in controls. In contrast to findings in the general population, the psychiatric problems of adolescents with AS/HFA are well acknowledged by multiple informants, including self-reports. However, anxiety and depressive symptoms were more commonly reported by adolescents with AS/HFA and their teachers than their parents, indicating that some emotional distress may be hidden from their parents.

  7. Report of JLC site study group

    CERN Document Server

    Hasegawa, T; Yamashita, S

    2003-01-01

    This study group selected some good sites for construction of JLC (Electron-Positron Linear Collider) on the basis of investigation of data and field survey. The aims, activity, use of underground of private land, conditions of site, selection of site at present and future, summary and proposal are reported. 9 sites (Hidaka, Kitakami, Murayama, Abukuma, Kitaibaraki, Aichi and Gifu, Takamatsu, Hiroshima and Seburi range) are selected for the construction on the basis of firm ground and 4 sites (Okinawa, Harima, Tsukuba and Mutsuogawara) for development and researches. 9 sites area consists of plutonic rock or old strata of Paleozoic era. Many problems in each site are reported. There are three following proposals; 1) the self-governing communities of the sites have to understand JLC and start to construct it by information, 2) a site evaluation committee consists of specialist of civil engineering, building, social and natural environment and disaster prevention and 3) the vibration test should be carried out ...

  8. Semiworks source aggregate area management study report

    International Nuclear Information System (INIS)

    1993-05-01

    This report presents the results of an aggregate area management study (AAMS) for the Semi-Works Aggregate Area in the 200 Areas of the US Department of Energy (DOE) . Hanford Site in Washington State. This scoping level study provides the basis for initiating Remedial Investigation/Feasibility Study (RI/FS) activities under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) or Resource Conservation and Recovery Act (RCRA) Facility Investigations WD and Corrective Measures Studies (CMS) under RCRA. This report also integrates select RCRA treatment storage, or disposal (TSD) closure activities with CERCLA and RCRA past-practice investigations. This approach is described and justified in The Hanford Federal Facility Agreement and Consent Order Change Package. This strategy provides new concepts for: accelerating decision-malting by maximizing the use of existing data consistent with data quality objectives (DQOs); and undertaking expedited response actions (ERAS) and/or interim remedial measures (IRMs), as appropriate, to either remove threats to human health and welfare and the environment, or to reduce risk by reducing toxicity, mobility, or volume of contaminants

  9. Preliminary Systems Design Study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Feizollahi, F.; Del Signore, J.C.

    1992-01-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept. This volume of the Systems Design Study contain four Appendixes that were part of the study. Appendix A is an EG ampersand G Idaho, Inc., report that represents a review and compilation of previous reports describing the wastes and quantities disposed in the Subsurface Disposal Area of the Idaho National Engineering Laboratory. Appendix B contains the process flowsheets considered in this study, but not selected for detailed analysis. Appendix C is a historical tabulation of radioactive waste incinerators. Appendix D lists Department of Energy facilities where cementation stabilization systems have been used

  10. Using RNA Interference to Study Protein Function

    OpenAIRE

    Curtis, Carol D.; Nardulli, Ann M.

    2009-01-01

    RNA interference can be extremely useful in determining the function of an endogenously-expressed protein in its normal cellular environment. In this chapter, we describe a method that uses small interfering RNA (siRNA) to knock down mRNA and protein expression in cultured cells so that the effect of a putative regulatory protein on gene expression can be delineated. Methods of assessing the effectiveness of the siRNA procedure using real time quantitative PCR and Western analysis are also in...

  11. Functional studies of sodium pump isoforms

    DEFF Research Database (Denmark)

    Clausen, Michael Jakob

    The Na+,K+-ATPase is an essential ion pump found in all animal cells. It uses the energy from ATP hydrolysis to export three Na+ and import two K+, both against their chemical gradients and for Na+ also against the electrical potential. Mammals require four Na+,K+-ATPase isoforms that each have...... unique expression profiles and specialized functional features. We use a Two Electrode Voltage Clamp setup to determine pre-steady-state and steady-state characteristics of each isoform and design chimeras to pin-point the structural elements responsible for observed differences. With this strategy we...

  12. Self-reported walking ability predicts functional mobility performance in frail older adults.

    Science.gov (United States)

    Alexander, N B; Guire, K E; Thelen, D G; Ashton-Miller, J A; Schultz, A B; Grunawalt, J C; Giordani, B

    2000-11-01

    To determine how self-reported physical function relates to performance in each of three mobility domains: walking, stance maintenance, and rising from chairs. Cross-sectional analysis of older adults. University-based laboratory and community-based congregate housing facilities. Two hundred twenty-one older adults (mean age, 79.9 years; range, 60-102 years) without clinical evidence of dementia (mean Folstein Mini-Mental State score, 28; range, 24-30). We compared the responses of these older adults on a questionnaire battery used by the Established Populations for the Epidemiologic Study of the Elderly (EPESE) project, to performance on mobility tasks of graded difficulty. Responses to the EPESE battery included: (1) whether assistance was required to perform seven Katz activities of daily living (ADL) items, specifically with walking and transferring; (2) three Rosow-Breslau items, including the ability to walk up stairs and walk a half mile; and (3) five Nagi items, including difficulty stooping, reaching, and lifting objects. The performance measures included the ability to perform, and time taken to perform, tasks in three summary score domains: (1) walking ("Walking," seven tasks, including walking with an assistive device, turning, stair climbing, tandem walking); (2) stance maintenance ("Stance," six tasks, including unipedal, bipedal, tandem, and maximum lean); and (3) chair rise ("Chair Rise," six tasks, including rising from a variety of seat heights with and without the use of hands for assistance). A total score combines scores in each Walking, Stance, and Chair Rise domain. We also analyzed how cognitive/ behavioral factors such as depression and self-efficacy related to the residuals from the self-report and performance-based ANOVA models. Rosow-Breslau items have the strongest relationship with the three performance domains, Walking, Stance, and Chair Rise (eta-squared ranging from 0.21 to 0.44). These three performance domains are as strongly

  13. Self-reported fatigue and physical function in late mid-life

    DEFF Research Database (Denmark)

    Boter, Han; Mänty, Minna; Hansen, Åse Marie

    2014-01-01

    Objective: To determine the association between the 5 subscales of the Multidimensional Fatigue Inventory (MFI-20) and physical function in late mid-life. Design: Cross-sectional study. Subjects: A population-based sample of adults who participated in the Copenhagen Aging and Midlife Biobank...... population cohort (n = 4,964; age 49-63 years). Methods: Self-reported fatigue was measured using the MFI-20 comprising: general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue. Handgrip strength and chair rise tests were used as measures of physical function. Multiple...... logistic regression analyses were used to determine the associations between handgrip strength and the chair rise test with the MFI-20 subscales, adjusted for potential confounders. Results: After adjustments for potential confounders, handgrip strength was associated with physical fatigue (adjusted odds...

  14. Self-Reported Decline in Everyday Function, Cognitive Symptoms, and Cognitive Function in People With HIV

    DEFF Research Database (Denmark)

    Laverick, Rosanna; Haddow, Lewis; Daskalopoulou, Marina

    2017-01-01

    BACKGROUND: We determined factors associated with self-reported decline in activities of daily living (ADLs) and symptoms of cognitive impairment in HIV positive adults in 5 European clinics. METHODS: HIV+ adults underwent computerized and pen-and-paper neuropsychological tests and questionnaires...

  15. Does Parent Report Gross Motor Function Level of Cerebral Palsy Children Impact on the Quality of Life in these Children?

    Science.gov (United States)

    Pashmdarfard, Marzieh; Amini, Malek; Badv, Reza Shervin; Ghaffarzade Namazi, Narges; Rassafiani, Mehdi

    2017-01-01

    The aim of this study was to assess the effect of parent report gross motor function level of cerebral palsy (CP) children on the parent report quality of life of CP children. Sampling of this cross-sectional study was done in occupational therapy clinics and CP children's schools in 2016 in Zanjan, Iran. Samples size was 60 CP children aged 6-12 yr and for sampling method, a non-probability convenience was used. For assessing the quality of life of CP children the cerebral palsy quality of life (CP QOL) questionnaire and for assessing the level of gross motor function of CP children the Gross Motor Function Classification System Family Report Questionnaire (GMFCSFRQ) were used. The average age of children (22 males and 30 females) was 8.92 yr old (minimum 6 yr and maximum 12 yr). The relationship between the level of gross motor function and participation and physical health was direct and significant (r=0.65). The relationship between functioning, access to services and family health with the level of gross motor function was direct but was not significant ( P >0.05) and the relationship between pain and impact of disability and emotional well-being with the level of gross motor function was significant ( P quality of life of children with cerebral palsy. It means that the level of gross motor function cannot be used as a predictor of quality of life for children with cerebral palsy alone.

  16. Halifax Lateral Pipeline Project : comprehensive study report

    International Nuclear Information System (INIS)

    1998-12-01

    The National Energy Board has requested the preparation of a comprehensive study report (CSR) for the proposed Halifax Lateral Pipeline Project in support of Maritimes and Northeast Pipeline Company's proposal to construct the lateral pipeline to transport natural gas produced in offshore Nova Scotia to the Tufts Cove electric generating station in the Halifax Regional Municipality. The project will also enhance the access of natural gas to potential markets located along the pipeline route. This CSR was prepared according to guidelines of the Canadian Environmental Assessment Agency. The report presents: (1) an overview of the project, (2) a summary of the regulatory requirements for assessment, (3) a description of the environmental assessment and regulatory process to date, (4) a summary of the predicted residual environmental and socio-economic effects associated with the project, and (5) a summary of the public consultation process. The environmental and socio-economic assessment focused on these eleven issues: groundwater resources, surface water resources, wetlands, soils, air quality, fish habitat, rare herpetiles, mammals, avifauna, rare plants and archaeological heritage resources. The report identified potential interactions between the project and valued socio-economic and environmental components. These were addressed in combination with recommended mitigative measures to reduce potential adverse effects. It was concluded that the overall environmental effects from the proposed project are likely to be minimal and can be effectively managed with good environmental management methods. 14 refs., 5 tabs., 5 figs., 2 appendices

  17. ICPP water inventory study project summary report

    International Nuclear Information System (INIS)

    Richards, B.T.

    1994-01-01

    The Idaho Chemical Processing Plant (ICPP) Water inventory Study was initiated in September 1993 with the formation of a joint working group consisting of representatives from DOE-ID, State of Idaho INEL Oversight Program, US Geological Survey, and INEL employees to investigate three issues that had been identified by the INEL Oversight Program at ICPP: (1) the water inventory imbalance at ICPP, (2) the source of water infiltrating into the Tank Farm vault sumps, and (3) the source of water providing potential recharge to perched water bodies underlying ICPP. These issues suggested that water was being lost from the ICPP distribution system. The INEL Oversight Program was concerned that the unaccounted for water at ICPP could be spreading contaminants that have been released over the past 40 years of operations of ICPP, possibly to the Snake River Plain Aquifer. This report summarizes the findings of each of the component investigations that were undertaken to resolve each of the three issues. Concerns about the risk of spreading contaminants will be resolved as part of the Remedial Investigation/Feasibility Study being undertaken at ICPP in compliance with the Federal Facility Agreement and Consent Order between DOE-H), EPA, and the State of Idaho. This report will be a key input to that study

  18. Effects of Two Concussions on the Neuropsychological Functioning and Symptom Reporting of High School Athletes.

    Science.gov (United States)

    Tsushima, William T; Geling, Olga; Arnold, Monica; Oshiro, Ross

    2016-01-01

    To assess the effects of two sports-related concussions on neuropsychological functioning and symptom reporting, the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) was administered to 483 high school athletes. Three groups of athletes were determined based on the number of previous concussions: no concussion (n = 409), 1 concussion (n = 58), and 2 concussions (n = 16). The results showed that the three groups did not differ in terms of their ImPACT composite scores (Verbal Memory, Visual Memory, Reaction Time, and Processing Speed) and the Total Symptom Score. As there are only a few studies that have reported the sequelae of 2 concussions in high school athletes, it is premature to declare that a repeated concussion does not have persistent neurocognitive effects on high school athletes.

  19. Gasohol: economic feasibility study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    David, M. L.; Hammaker, G. S.; Buzenberg, R. J.; Wagner, J. P.

    1978-07-01

    This report was prepared by Development Planning and Research Associates, Inc. under a contract with the Energy Research and Development Center of the University of Nebraska in cooperation with the Agricultural Products Industrial Utilization Committee and the State of Nebraska. Funding for this study was provided to the Energy Research and Development Center by the U.S. Department of Energy and the Old West Regional Commission. The primary objective of the study was to: determine the fiscal and market conditions under which the production of gasohol would be profitable for private producers. For purposes of this study, gasohol is a motor fuel consisting of 10 percent agriculturally-derived anhydrous ethanol and 90 percent unleaded gasoline. The study assumes that gasohol can be a fuel substitute for gasoline; indeed, the cost of gasoline will significantly influence that for gasohol. Gasoline prices are determined by factors external to ethanol; thus, the economic feasibility study of gasohol is in large part an economic feasibility study of fuel-grade ethanol production. More specifically, the study examined the following: the technical aspects of distributing, marketing, and using gasohol; the costs of the distribution and marketing of ethanol and gasohol; the energy balance of ethanol production; the cost of producing ethanol; the factors influencing ehtanol plant size and location; and the conditions that would make ethanol economicaly feasible for private producers.

  20. [The Strengthening the Reporting of Observational Studies in Epidemiology [STROBE] statement: guidelines for reporting observational studies

    DEFF Research Database (Denmark)

    Elm, E. von; Altman, D.G.; Egger, M.

    2008-01-01

    Much biomedical research is observational. The reporting of such research is often inadequate, which hampers the assessment of its strengths and weaknesses and of a study's generalisability. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) initiative developed...... recommendations on what should be included in an accurate and complete report of an observational study. We defined the scope of the recommendations to cover three main study designs: cohort, case-control, and cross-sectional studies. We convened a 2-day workshop in September, 2004, with methodologists...... and the subsequent iterative process of consultation and revision resulted in a checklist of 22 items (the STROBE statement) that relate to the title, abstract, introduction, methods, results, and discussion sections of articles. 18 items are common to all three study designs and four are specific for cohort, case...

  1. Nova Scotia wind integration study : final report

    International Nuclear Information System (INIS)

    2008-01-01

    An independent study was commissioned by the Nova Scotia Department of Energy to identify and assess the impacts of integrating large scale wind power generation into Nova Scotia's electric power system. The purpose of the study was to help Nova Scotia's efforts towards building its renewable energy supply, in order to secure a local energy resource and to protect the environment. This report provided an overview of Nova Scotia's electric power sector, including organizations involved; existing generation system; existing transmission system; renewable energy standards; Nova Scotia Power integrated resource plan; and 2007 renewable energy request for proposals. The major assumptions for the study that were discussed included system parameters; system capacity reserve requirements; expansion plans to 2020; and allocation of new wind generation by zone. Wind resource data and system dispatch modeling were also presented and transmission system modeling was outlined. This included a discussion of steady state reliability requirements; inputs to the load flow model; load flow study and contingency analysis; intra-province transmission congestion; and potential impacts on system security. The report also presented an approach to impact analysis and mitigation such as the impact on greenhouse gas and other air emissions and the impact of wind energy prices on system costs. It was concluded that one of the most important factors in evaluation of the economic impact of wind power integration is the forecasted fuel prices for the thermal units. If the fuel prices had varied significantly from the forecasted values, the study economic impact results could have been quite different. 55 tabs., 64 figs., 1 appendix

  2. Academic procrastination in college students: the role of self-reported executive function.

    Science.gov (United States)

    Rabin, Laura A; Fogel, Joshua; Nutter-Upham, Katherine E

    2011-03-01

    Procrastination, or the intentional delay of due tasks, is a widespread phenomenon in college settings. Because procrastination can negatively impact learning, achievement, academic self-efficacy, and quality of life, research has sought to understand the factors that produce and maintain this troublesome behavior. Procrastination is increasingly viewed as involving failures in self-regulation and volition, processes commonly regarded as executive functions. The present study was the first to investigate subcomponents of self-reported executive functioning associated with academic procrastination in a demographically diverse sample of college students aged 30 years and below (n = 212). We included each of nine aspects of executive functioning in multiple regression models that also included various demographic and medical/psychiatric characteristics, estimated IQ, depression, anxiety, neuroticism, and conscientiousness. The executive function domains of initiation, plan/organize, inhibit, self-monitor, working memory, task monitor, and organization of materials were significant predictors of academic procrastination in addition to increased age and lower conscientiousness. Results enhance understanding of the neuropsychological correlates of procrastination and may lead to practical suggestions or interventions to reduce its harmful effects on students' academic performance and well-being.

  3. Effect of object functions on tomographic reconstruction a numerical study

    International Nuclear Information System (INIS)

    Babu Rao, C.; Baldev Raj; Ravichandran, V.S.; Munshi, P.

    1996-01-01

    Convolution back projection is the most widely used algorithm of computed tomography (CT). Theoretical studies show that under ideal conditions, the error in the reconstruction can be correlated with the second fourier space derivative of filter function and with the Laplacian of the object function. This paper looks into the second aspect of the error function. In this paper a systematic numerical study is presented on the effect to object functions on global and local errors. (author)

  4. Study of sexual functioning and disorder in women before and after tubal sterilization (tubectomy)

    OpenAIRE

    Kunkeri, Shweta Patil; Sathyanarayana Rao, T. S.; Andrade, Chittaranjan

    2017-01-01

    Introduction: Sexual relationship is a basis for mental health and continuity of the healthy generation. There are very few studies on the female sexual functioning, especially in India. Sterilization being the most common contraceptive method, sexual functioning in women undergoing this surgical intervention has not been adequately explored. Available studies have found conflicting results; some have reported that sterilization has positive effects on sexual functioning since anxiety of gett...

  5. Life span study report, 11, part 2

    International Nuclear Information System (INIS)

    Shimizu, Yukiko; Kato, Hiroo; Schull, W.J.

    1988-12-01

    ABCC and its successor, RERF, have followed since 1959 and retrospectively to 1950 the mortality in a fixed cohort of survivors of the atomic bombings of Hiroshima and Nagasaki, the so-called Life Span Study sample. The present study, the 11th in a series that began in 1961, extends the surveillance period three more years and covers the period 1950-85. It is based on the recently revised dose system, called DS86, that has replaced previous estimates of individual exposures. The impact of the change from the old system of dosimetry, the T65DR, to the new on the dose-response relationships for cancer mortality was described in the first of this series of reports. Here, the focus is on cancer mortality among the 76,000 A-bomb survivors within the LSS sample for whom DS86 doses have been estimated, with the emphasis on biological issues associated with radiation carcinogenesis. (author)

  6. Gunnison, Colorado subpile study report. Revision 1

    International Nuclear Information System (INIS)

    1994-08-01

    To protect human health and the environment, the Uranium Mill Tailings Remedial Action (UMTRA) Project will remediate the uranium mill tailings site at Gunnison Colorado. There are explicit requirements (i.e., 40 CFR Part 192) for the surface remediation of radiologically contaminated soils on UMTRA sites. The removal of subpile sediment to the depth required by 40 CFR Part 192 will leave in place deeper foundation sediment that is contaminated with hazardous constituents other than radium-226 and thorium-230. The Department of Energy and the Colorado Department of Health have questioned whether this contaminated soil could potentially act as a continuing source of ground water contamination even after surface remediation based on 40 CFR Part 192 is complete. To evaluate the subpile sediments as a potential source of ground water contamination, the Gunnison Subpile study was initiated. This report summarizes the results and findings of this study

  7. ICPP water inventory study progress report

    International Nuclear Information System (INIS)

    Richards, B.T.

    1993-05-01

    Recent data from the Idaho Chemical Processing Plant (ICPP) indicate that water is entering the sumps located in the bottom of Tank Firm Vaults in quantities that exceed expected levels. In addition, perched water body(s) exist beneath the northern portion of the ICPP. Questions have been raised concerning the origin of water entering the Tank Farm sumps and the recharge sources for the perched water bodies. Therefore, in an effort to determine the source of water, a project has been initiated to identify the source of water for Tank Farm sumps and the perched water bodies. In addition, an accurate water balance for the ICPP will be developed. The purpose of this report is to present the specific results and conclusions for the ICPP water balance portion of the study. In addition, the status of the other activities being conducted as part of study, along with the associated action plans, is provided

  8. Environmental studies group. Annual report for 1978

    International Nuclear Information System (INIS)

    Hunt, D.C.; Hurley, J.D.

    1980-01-01

    Group projects included radioecological studies of aquatic and terrestrial systems, land management activities, foodstuff monitoring, dust transport studies including fugitive dust measurements and modeling, and several support programs involving evaluation of the plant's ambient air samplers and airborne tritium monitoring techniques. Some salient results from the several project reports include determination of an appropriate model for mechanically generated fugitive dust dispersion, a radionuclide inventory of Smart Ditch Pond (Pond D-1), a coefficient of community determination for two terrestrial sample plots on the plant site buffer zone, a natality and mortality rate determination for fawns in the plant deer herd (including one positive coyote-kill determination), inlet loss and filter paper collection efficiencies for the plant ambient air samplers, and differential tritium sampling measurements of the vapor in Building 771 stack effluent

  9. ICPP water inventory study progress report

    Energy Technology Data Exchange (ETDEWEB)

    Richards, B.T.

    1993-05-01

    Recent data from the Idaho Chemical Processing Plant (ICPP) indicate that water is entering the sumps located in the bottom of Tank Firm Vaults in quantities that exceed expected levels. In addition, perched water body(s) exist beneath the northern portion of the ICPP. Questions have been raised concerning the origin of water entering the Tank Farm sumps and the recharge sources for the perched water bodies. Therefore, in an effort to determine the source of water, a project has been initiated to identify the source of water for Tank Farm sumps and the perched water bodies. In addition, an accurate water balance for the ICPP will be developed. The purpose of this report is to present the specific results and conclusions for the ICPP water balance portion of the study. In addition, the status of the other activities being conducted as part of study, along with the associated action plans, is provided.

  10. Environmental studies group. Annual report for 1978

    Energy Technology Data Exchange (ETDEWEB)

    Hunt, D. C.; Hurley, J. D. [eds.

    1980-08-21

    Group projects included radioecological studies of aquatic and terrestrial systems, land management activities, foodstuff monitoring, dust transport studies including fugitive dust measurements and modeling, and several support programs involving evaluation of the plant's ambient air samplers and airborne tritium monitoring techniques. Some salient results from the several project reports include determination of an appropriate model for mechanically generated fugitive dust dispersion, a radionuclide inventory of Smart Ditch Pond (Pond D-1), a coefficient of community determination for two terrestrial sample plots on the plant site buffer zone, a natality and mortality rate determination for fawns in the plant deer herd (including one positive coyote-kill determination), inlet loss and filter paper collection efficiencies for the plant ambient air samplers, and differential tritium sampling measurements of the vapor in Building 771 stack effluent.

  11. A transgenic Xenopus laevis reporter model to study lymphangiogenesis

    Directory of Open Access Journals (Sweden)

    Annelii Ny

    2013-07-01

    The importance of the blood- and lymph vessels in the transport of essential fluids, gases, macromolecules and cells in vertebrates warrants optimal insight into the regulatory mechanisms underlying their development. Mouse and zebrafish models of lymphatic development are instrumental for gene discovery and gene characterization but are challenging for certain aspects, e.g. no direct accessibility of embryonic stages, or non-straightforward visualization of early lymphatic sprouting, respectively. We previously demonstrated that the Xenopus tadpole is a valuable model to study the processes of lymphatic development. However, a fluorescent Xenopus reporter directly visualizing the lymph vessels was lacking. Here, we created transgenic Tg(Flk1:eGFP Xenopus laevis reporter lines expressing green fluorescent protein (GFP in blood- and lymph vessels driven by the Flk1 (VEGFR-2 promoter. We also established a high-resolution fluorescent dye labeling technique selectively and persistently visualizing lymphatic endothelial cells, even in conditions of impaired lymph vessel formation or drainage function upon silencing of lymphangiogenic factors. Next, we applied the model to dynamically document blood and lymphatic sprouting and patterning of the initially avascular tadpole fin. Furthermore, quantifiable models of spontaneous or induced lymphatic sprouting into the tadpole fin were developed for dynamic analysis of loss-of-function and gain-of-function phenotypes using pharmacologic or genetic manipulation. Together with angiography and lymphangiography to assess functionality, Tg(Flk1:eGFP reporter tadpoles readily allowed detailed lymphatic phenotyping of live tadpoles by fluorescence microscopy. The Tg(Flk1:eGFP tadpoles represent a versatile model for functional lymph/angiogenomics and drug screening.

  12. FY 1998 annual summary report on comprehensive development study of high-function flat panel display techniques (second year); 1998 nendo koseino flat panel display gijutsu no sogo kaihatsu kenkyu seika hokokusho. Daininendo

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    This project is aimed at creation of the new world display industry in Shikoku by developing the high-function flat panel display techniques and thereby establishing new techniques which solve the problems involved in, e.g., LEDs, plasma-aided devices and ELs other than liquid crystal devices. For development of emitters using diamond, important results have been obtained for the morphology, and cathode luminescence, Raman and photoluminescence spectra of polycrystalline diamond, synthesized by the vapor-phase process under varying conditions, on the electron radiation characteristics of the emitters. These results have led to clarification of the optimum vapor-phase synthesis conditions for diamond for high-function emitters. The techniques utilizing focused ion beams have also advanced to develop thin polycrystalline diamond films for emitters which correspond to the image elements of quality for television. For electron emitters, a structure prepared by implantation without using a high electrical field is proposed, and the device mechanisms involved are clarified. (NEDO)

  13. Report on the uncertainty methods study

    International Nuclear Information System (INIS)

    1998-06-01

    The Uncertainty Methods Study (UMS) Group, following a mandate from CSNI, has compared five methods for calculating the uncertainty in the predictions of advanced 'best estimate' thermal-hydraulic codes: the Pisa method (based on extrapolation from integral experiments) and four methods identifying and combining input uncertainties. Three of these, the GRS, IPSN and ENUSA methods, use subjective probability distributions, and one, the AEAT method, performs a bounding analysis. Each method has been used to calculate the uncertainty in specified parameters for the LSTF SB-CL-18 5% cold leg small break LOCA experiment in the ROSA-IV Large Scale Test Facility (LSTF). The uncertainty analysis was conducted essentially blind and the participants did not use experimental measurements from the test as input apart from initial and boundary conditions. Participants calculated uncertainty ranges for experimental parameters including pressurizer pressure, primary circuit inventory and clad temperature (at a specified position) as functions of time

  14. Mackenzie Basin impact study: Interim report 1

    International Nuclear Information System (INIS)

    Cohen, S.J.

    1993-01-01

    The Mackenzie Basin Impact Study (MIBS) is a six-year study undertaken to assess the potential impacts on the Mackenzie River Basin region and its inhabitants. The study framework, structure, organization, methods, and data are described. Highlights of work to date are reviewed. The MBIS employs scenarios of future warmer climates and changes in population and economic conditions. Research is coordinated by an interagency working committee and research activities cover 28 areas including permafrost, hydrology, sea ice, boreal ecosystems, freshwater fish, wildlife, forestry, agriculture, tourism, community studies, and defense. Six issues have been identified: interjurisdictional water management, sustainability of native lifestyles, economic development opportunities, infrastructure and buildings, and sustainability of ecosystems. An integrated assessment approach is used in the MBIS, combining scientific and indigenous traditional knowledge and attempting to include all interactions that occur between sectors. Two methods are being developed: socio-economic integration using a resource accounting framework, and an integrated land assessment framework. Four scenarios of warmer climates have been developed, all showing increased precipitation for the basin as a whole. Moderate growth in the resource sector is predicted. Preliminary results of some research are reported, including a lengthened open-water season in the Beaufort Sea accompanied by a greater extent of open water. 44 figs., 16 tabs

  15. Fire PRA requantification studies. Final report

    International Nuclear Information System (INIS)

    Parkinson, W.

    1993-03-01

    This report describes the requantification of two existing fire probabilistic risk assessments (PRAs) using a fire PRA method and data that are being developed by the Electric Power Research Institute (EPRI). The two existing studies are the Seabrook Station Probabilistic Safety Assessment that was made in 1983 and the 1989 NUREG-1150 analysis of the Peach Bottom Plant. Except for the fire methods and data, the original assumptions were used. The results from the requantification show that there were excessive conservatisms in the original studies. The principal reason for a hundredfold reduction in the Peach Bottom core- damage frequency is the determination that no electrical cabinet fire in a switchgear room would damage both offsite power feeds. Past studies often overestimated the heat release from electrical cabinet fires. EPRI's electrical cabinet heat release rates are based on tests that were conducted for Sandia's fire research program. The rates are supported by the experience in the EPRI Fire Events Database for U.S. nuclear plants. Test data and fire event experience also removed excessive conservatisms in the Peach Bottom control and cable spreading rooms, and the Seabrook primary component cooling pump, turbine building relay and cable spreading rooms. The EPRI fire PRA method and data will show that there are excessive conservatisms in studies that were made for many plants and can benefit them accordingly

  16. Additional EIPC Study Analysis. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Hadley, Stanton W [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gotham, Douglas J. [Purdue Univ., West Lafayette, IN (United States); Luciani, Ralph L. [Navigant Consultant Inc., Suwanee, GA (United States)

    2014-12-01

    Between 2010 and 2012 the Eastern Interconnection Planning Collaborative (EIPC) conducted a major long-term resource and transmission study of the Eastern Interconnection (EI). With guidance from a Stakeholder Steering Committee (SSC) that included representatives from the Eastern Interconnection States Planning Council (EISPC) among others, the project was conducted in two phases. Phase 1 involved a long-term capacity expansion analysis that involved creation of eight major futures plus 72 sensitivities. Three scenarios were selected for more extensive transmission- focused evaluation in Phase 2. Five power flow analyses, nine production cost model runs (including six sensitivities), and three capital cost estimations were developed during this second phase. The results from Phase 1 and 2 provided a wealth of data that could be examined further to address energy-related questions. A list of 14 topics was developed for further analysis. This paper brings together the earlier interim reports of the first 13 topics plus one additional topic into a single final report.

  17. DER Benefits Analysis Studies: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Iannucci, J. J.; Cibulka, L.; Eyer, J. M.; Pupp, R. L.

    2003-09-01

    The electric power industry in the United States is undergoing dramatic change. Once totally controlled by utilities that had monopolistic holds on the supply, transmission and distribution of electricity in their service areas, the electric power system is being deregulated, introducing competition among electricity providers who can distinguish themselves by price, services and other factors. The new electric power system will feature advanced technologies and services that can be used on-site or located in close proximity to the load, instead of depending solely upon large, central station generation and transmission. Using a variety of advanced modular generating technologies (including small-scale renewables), distributed energy resource (DER) plants supply base-load power, peaking power, backup power, remote power and/or heating and cooling, and in some cases supply higher and more reliable quality power. Currently, DER represent a minor part of the electric supply system. If the potential of DER is to be realized in the new electric power market, a full understanding of the value and benefits these technologies provide to the electric system is necessary. This report includes 30 key quantitative studies reporting on the values and benefits of distributed energy generation technologies (including renewables) in various applications, as well as a matrix that permits key comparisons.

  18. Functional approaches in translation studies in Germany Functional approaches in translation studies in Germany

    Directory of Open Access Journals (Sweden)

    Paul Kussmaul

    2008-04-01

    Full Text Available In the early phase of translation studies in Germany, contrastive linguistics played a major role. I shall briefly describe this approach so that the functional approach will become clearer by contrast. Influenced by the representatives of stylistique comparée, Vinay/Darbelnet (1968 Wolfram Wilss, for instance, in his early work (1971, 1977 makes frequent use of the notion transposition (German “Ausdrucksverschiebung“, cf. also Catford’s (1965 term shift. As a whole, of course, Wilss’ work has a much broader scope. More recently, he has investigated the role of cognition (1988 and the various factors in translator behaviour (1996. Nevertheless, transposition is still a very important and useful notion in describing the translation process. The need for transpositions arises when there is no possibility of formal one-to-one correspondence between source and target-language structures. The basic idea is that whenever there is a need for transposition, we are faced with a translation problem. In the early phase of translation studies in Germany, contrastive linguistics played a major role. I shall briefly describe this approach so that the functional approach will become clearer by contrast. Influenced by the representatives of stylistique comparée, Vinay/Darbelnet (1968 Wolfram Wilss, for instance, in his early work (1971, 1977 makes frequent use of the notion transposition (German “Ausdrucksverschiebung“, cf. also Catford’s (1965 term shift. As a whole, of course, Wilss’ work has a much broader scope. More recently, he has investigated the role of cognition (1988 and the various factors in translator behaviour (1996. Nevertheless, transposition is still a very important and useful notion in describing the translation process. The need for transpositions arises when there is no possibility of formal one-to-one correspondence between source and target-language structures. The basic idea is that whenever there is a need for

  19. Summary Report of the Consultants' Meeting on EXFOR Data in Resonance Region and Spectrometer Response Function

    International Nuclear Information System (INIS)

    Gunsing, F.; Schillebeeckx, P.; Semkova, V.

    2013-12-01

    The Consultants' Meeting 'EXFOR Data in Resonance Region and Spectrometer Response Function' was held at the IAEA Headquarters in Vienna from 8 to 10 October 2013. A summary of the presentations and discussions that took place during the meeting is reported here. The participants have agreed on recommendations on data reporting for EXFOR and on the need of documenting spectrometer response functions. Recommendations are given for experimentalists, for compilers, and for evaluators. (author)

  20. Accelerator research studies: Progress report, Task C

    International Nuclear Information System (INIS)

    1985-06-01

    The major effort reported is the study of the feasibility of a 300 MW gyroklystron at ∼9 GHz, and substantial progress has been made. A four-cavity gyroklystron design has been shown to be capable of linear gain as high as 66 dB and to be marginally stable against oscillation in any mode. AM and PM sensitivities to fluctuation in system parameters have also been calculated in the regime of linear operation. Initial non-linear design calculations have also been carried out which include the effect of tapering the axial magnetic guide field over the length of a gyroklystron circuit. Although these calculations are preliminary they do indicate potential for significant efficiency enhancement by magnetic field shaping techniques

  1. Theoretical studies of controlled fusion: Final report

    International Nuclear Information System (INIS)

    Krall, N.A.

    1987-01-01

    This report summarizes the results of a study of low frequency stability in the Field Reversed Configuration (FRC), with emphasis on the transport resulting from this stability behavior. Anomalous transport plays an obvious role in the confinement physics of the Field Reversed Configuration. Other anomalies are also observed, including an apparent absence of MHD instability and, in some cases, of lower-hybrid-drift instability. In current FRC experiments at LANL and Spectra Technology, particle, energy, and magnetic flux loss are observed to differ from classical prediction, both in size and in scaling. Early models proposed to explain that transport properties were based on anomalous radial loss of plasma particles in the vicinity of the separatrix between closed and open field lines produced by lower-hybrid instabilities. Our present work has shown that low frequency drift waves were also unstable in FRC, and produce energy and flux loss consistent with observation. 11 refs., 5 figs., 2 tabs

  2. Environmental Studies Group progress report for 1979

    International Nuclear Information System (INIS)

    Hunt, D.C.; Hurley, J.D.

    1981-01-01

    The 1979 progress report gives descriptions, results, and/or status on programs involving (1) physical transport of radionuclides in blowing dust, (2) radionuclide distributions in the sediment of area water bodies, (3) management of open space lands (including a remote sensing program) at Rocky Flats, (4) the ecology and radioecology of terrestrial open space areas in Plant site lands, (5) biological pathways for radionuclide transport, (6) evaluations of environmental monitoring data on radionuclides in air and water, (7) results of a special soil sampling program on lands adjacent to the Plant site, and (8) two special programs - one concerning evaluations of epidemiological studies of health effects purported to be related to the Plant, and a second that specifies information on accumulations of material in process building filter plenums required for evaluation of potential accidents

  3. Study of Travelling Interplanetary Phenomena Report

    Science.gov (United States)

    Dryer, Murray

    1987-09-01

    Scientific progress on the topic of energy, mass, and momentum transport from the Sun into the heliosphere is contingent upon interdisciplinary and international cooperative efforts on the part of many workers. Summarized here is a report of some highlights of research carried out during the SMY/SMA by the STIP (Study of Travelling Interplanetary Phenomena) Project that included solar and interplanetary scientists around the world. These highlights are concerned with coronal mass ejections from solar flares or erupting prominences (sometimes together); their large-scale consequences in interplanetary space (such as shocks and magnetic 'bubbles'); and energetic particles and their relationship to these large-scale structures. It is concluded that future progress is contingent upon similar international programs assisted by real-time (or near-real-time) warnings of solar activity by cooperating agencies along the lines experienced during the SMY/SMA.

  4. Anxiety or neurosis: case report study

    Directory of Open Access Journals (Sweden)

    Miloš Židanik

    2005-11-01

    Full Text Available Background: With the publication of the Diagnostic and Statistical Manual, Third Edition (DSM-III in 1980, anxiety disorder was first identified as a diagnostic entity. A new theoretical approach regarding aetiology of anxiety disorders came next into the view, far from Freud’s psychoanalytical pathways. The consequences were new therapeutic guidelines, including psychopharmacotherapy and the use of behavioural and cognitive psychotherapy.Methods: The paper presents a case report study of a patient with social phobia. The use of analytical oriented psychotherapy, which helped to resolve Axis I symptoms, is described.Conclusions: In spite of new therapeutic guidelines there is still a certain population of patients with the need for psychoanalytical oriented psychotherapy. If we are to surrender the Freud’s legacy to the medical history, we will weaken psychiatry as a science and will narrow our therapeutic field.

  5. High-Level Waste Melter Study Report

    Energy Technology Data Exchange (ETDEWEB)

    Perez, Joseph M.; Bickford, Dennis F.; Day, Delbert E.; Kim, Dong-Sang; Lambert, Steven L.; Marra, Sharon L.; Peeler, David K.; Strachan, Denis M.; Triplett, Mark B.; Vienna, John D.; Wittman, Richard S.

    2001-07-13

    At the Hanford Site in Richland, Washington, the path to site cleanup involves vitrification of the majority of the wastes that currently reside in large underground tanks. A Joule-heated glass melter is the equipment of choice for vitrifying the high-level fraction of these wastes. Even though this technology has general national and international acceptance, opportunities may exist to improve or change the technology to reduce the enormous cost of accomplishing the mission of site cleanup. Consequently, the U.S. Department of Energy requested the staff of the Tanks Focus Area to review immobilization technologies, waste forms, and modifications to requirements for solidification of the high-level waste fraction at Hanford to determine what aspects could affect cost reductions with reasonable long-term risk. The results of this study are summarized in this report.

  6. Centrifuge workers study. Phase II, completion report

    Energy Technology Data Exchange (ETDEWEB)

    Wooten, H.D.

    1994-09-01

    Phase II of the Centrifuge Workers Study was a follow-up to the Phase I efforts. The Phase I results had indicated a higher risk than expected among centrifuge workers for developing bladder cancer when compared with the risk in the general population for developing this same type of cancer. However, no specific agent could be identified as the causative agent for these bladder cancers. As the Phase II Report states, Phase I had been limited to workers who had the greatest potential for exposure to substances used in the centrifuge process. Phase II was designed to expand the survey to evaluate the health of all employees who had ever worked in Centrifuge Program Departments 1330-1339 but who had not been interviewed in Phase I. Employees in analytical laboratories and maintenance departments who provided support services for the Centrifuge Program were also included in Phase II. In December 1989, the Oak Ridge Associated Universities (ORAU), now known as Oak Ridge Institute for Science and Education (ORISE), was contracted to conduct a follow-up study (Phase II). Phase H of the Centrifuge Workers Study expanded the survey to include all former centrifuge workers who were not included in Phase I. ORISE was chosen because they had performed the Phase I tasks and summarized the corresponding survey data therefrom.

  7. Centrifuge workers study. Phase II, completion report

    International Nuclear Information System (INIS)

    Wooten, H.D.

    1994-09-01

    Phase II of the Centrifuge Workers Study was a follow-up to the Phase I efforts. The Phase I results had indicated a higher risk than expected among centrifuge workers for developing bladder cancer when compared with the risk in the general population for developing this same type of cancer. However, no specific agent could be identified as the causative agent for these bladder cancers. As the Phase II Report states, Phase I had been limited to workers who had the greatest potential for exposure to substances used in the centrifuge process. Phase II was designed to expand the survey to evaluate the health of all employees who had ever worked in Centrifuge Program Departments 1330-1339 but who had not been interviewed in Phase I. Employees in analytical laboratories and maintenance departments who provided support services for the Centrifuge Program were also included in Phase II. In December 1989, the Oak Ridge Associated Universities (ORAU), now known as Oak Ridge Institute for Science and Education (ORISE), was contracted to conduct a follow-up study (Phase II). Phase H of the Centrifuge Workers Study expanded the survey to include all former centrifuge workers who were not included in Phase I. ORISE was chosen because they had performed the Phase I tasks and summarized the corresponding survey data therefrom

  8. The Need for a Uniform Method of Recording and Reporting Functional Vision Assessments

    Science.gov (United States)

    Shaw, Rona; Russotti, Joanne; Strauss-Schwartz, Judy; Vail, Helen; Kahn, Ronda

    2009-01-01

    The use of functional vision by school-age students who have visual impairments, including those with additional disabilities, is typically reported by teachers of students with visual impairments. Functional vision assessments determine how well a student uses his or her vision to perform tasks throughout the school day. The information that is…

  9. Scanning the Global Environment. A framework and methodology for UNEP's reporting functions

    NARCIS (Netherlands)

    Swart RJ; Bakkes JA; Niessen LW; Rotmans J; Vries HJM de; Weterings R; Rijksinstituut voor; United Nations Environment Programme UNEP; MTV; ISC; VTV; CWM; SB4; TNO Centre for Technology and Policy

    1994-01-01

    A conceptual framework for UNEP's reporting functions is proposed, aimed at supporting strategic environmental policy development. To this end information should be provided about the past, current and future state of the environment as a function of demographic and socio-economic developments.

  10. Progress report on nuclear structure studies

    International Nuclear Information System (INIS)

    Walters, W.B.

    1991-01-01

    In this report, new results are reported for the decay and nuclear orientation of 114,116 I and 114 Sb as well as data for the structure of daughter nuclides 114,116 Te. New results for IBM-2 calculations for the structure of 126 Xe are also reported. 6 figs., 5 tabs

  11. Fundamental studies of fusion plasmas. Final report

    International Nuclear Information System (INIS)

    Aamodt, R.E.

    1998-01-01

    Lodestar has carried out a vigorous research program in the areas of rf, edge plasma and divertor physics, with emphasis largely geared towards improving the understanding and performance of ion-cyclotron heating and current drive (ICRF) systems. Additionally, a research program in the field of edge plasma and divertor modeling was initiated. Theoretical work on high power rf sheath formation for multi-strap rf arrays was developed and benchmarked against recent experimental data from the new JET A2 antennas. Sophisticated modeling tools were employed to understand the sheath formation taking into account realistic three-dimensional antenna geometry. A novel physics explanation of an observed anomaly in the low power loading of antennas was applied to qualitatively interpret data on DIII-D in terms of rf sheaths, and potential applications of the idea to develop a near-field sheath diagnostic were explored. Other rf-wave related topics were also investigated. Full wave ICRF modeling studies were carried out in support of ongoing and planned tokamaks experiments, including the investigation of low frequency plasma heating and current drive regimes for IGNITOR. In a cross-disciplinary study involving both MHD and ICRF physics, ponderomotive feedback stabilization by rf was investigated as a potential means of controlling external kink mode disruptions. In another study, the instability of the ion hybrid wave (IHW) in the presence of fusion alpha particles was studied. In the field of edge plasma and divertor modeling studies, Lodestar began the development of a theory of generalized ballooning and sheath instabilities in the scrape off layer (SOL) of divertor tokamaks. A detailed summary of the technical progress in these areas during the contract period is included, as well as where references to published work can be found. A separate listing of publications, meeting abstracts, and other presentations is also given at the end of this final report

  12. Function Plotters for Secondary Math Teachers. A MicroSIFT Quarterly Report.

    Science.gov (United States)

    Weaver, Dave; And Others

    This report examines mathematical graphing utilities or function plotters for use in introductory algebra classes of more advanced courses. Each product selected for inclusion in this report is able to construct the graph of a given equation on the screen and serves as a utility which may be used by the student for an open-ended exploration of a…

  13. Measuring Disability in Population Based Surveys: The Interrelationship between Clinical Impairments and Reported Functional Limitations in Cameroon and India.

    Science.gov (United States)

    Mactaggart, Islay; Kuper, Hannah; Murthy, G V S; Oye, Joseph; Polack, Sarah

    2016-01-01

    assess reported functional limitation alone are insufficient to identify all persons with participation restrictions and moderate or severe clinical impairments. A self-reported functional limitation tool followed by clinical screening of all those who report any level of difficulty would identify 94% of people with disabilities in Cameroon and 95% in India, meeting the study criteria.

  14. FY 2000 report on the investigational study of neutron resistance of high functional semiconductor parts. Summary; Chosa hokokusho. Kokino handotai buhin no chuseisisen taisei no chosa kenkyu(Yoyaku ban)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    Soft error induced by cosmic ray was becoming a problem also on the earth surface together with more integration/minuteness of memory device, and therefore, survey of the research trend and extraction of R and D subjects were carried out as to the difference in the state of occurrence of single event upset (SEU) and the evaluation method using neutron beam. Concerning the state of SEU occurrence, survey was made paying attention to the field test, accelerator test and airplane test. There were few reports on the field test, and it was found that it was difficult to arrange environmental parameters. Relating to the mechanism of SEU occurrence, confirmed was a possibility that there was a difference in SEU between proton beam and neutron beam. Further, as to the measurement and simulation of neutron spectra, it was found that there was no enough accuracy. About the evaluation method for neutron beam resistance, it was found that the high energy neutron beam emission device was becoming usable. The paper also outlined the SEU evaluation method. (NEDO)

  15. Smoking cessation, lung function, and weight gain : a follow-up study

    NARCIS (Netherlands)

    Chinn, S; Jarvis, D; Melotti, R; Luczynska, C; Ackermann-Liebrich, U; Anto, JM; Cerveri, [No Value; de Marco, R; Gislason, T; Heinrich, J; Janson, C; Kunzli, N; Leynaert, B; Neukirch, F; Schouten, J; Sunyer, J; Svanes, C; Vermeire, P; Wjst, M; Burney, P

    2005-01-01

    Background Only one population-based study in one country has reported effects of smoking cessation and weight change on lung function, and none has reported the net effect. We estimated the net benefit of smoking cessation, and the independent effects of smoking and weight change on change in

  16. Progress report on nuclear spectroscopic studies

    International Nuclear Information System (INIS)

    Bingham, C.R.; Riedinger, L.L.; Sorensen, S.P.

    1996-01-01

    The experimental program in nuclear physics at the University of Tennessee, Knoxville, is led by Professors Carrol Bingham, Lee Riedinger, and Soren Sorenseni who respectively lead the studies of the exotic decay modes of nuclei far from stability, the program of high-spin research, and our effort in relativistic heavy-ion physics. Over the years, this broad program of research has been successful partially because of the shared University resources applied to this group effort. The proximity of the Oak Ridge National Laboratory has allowed us to build extremely strong programs of joint research, and in addition to play an important leadership role in the Joint Institute for Heavy Ion Research (JIHIR). Our experimental program is also very closely linked with those at other national laboratories: Argonne (collaborations involving the Fragment Mass Analyzer (FMA) and γ-ray arrays), Brookhaven (the RHIC and Phenix projects), and Berkeley (GAMMASPHERE). We have worked closely with a variety of university groups in the last three years, especially those in the UNISOR and now UNIRIB collaborations. And, in all aspects of our program, we have maintained close collaborations with theorists, both to inspire the most exciting experiments to perform and to extract the pertinent physics from the results. The specific areas discussed in this report are: properties of high-spin states; study of low-energy levels of nuclei far from stability; and high energy heavy-ion physics

  17. FY-1979 progress report. Hydrotransport plugging study.

    Energy Technology Data Exchange (ETDEWEB)

    Eyler, L.L.; Lombardo, N.J.

    1980-01-01

    The objective of the Hydrotransport Plugging Study is to investigate phenomena associated with predicting the onset and occurrence of plugging in pipeline transport of coal. This study addresses large particle transport plugging phenomena that may be encountered in run-of-mine operations. The project is being conducted in four tasks: review and analysis of current capabilities and available data, analytical modeling, experimental investigations, and unplugging and static start-up. This report documents work completed in FY-1979 as well as work currently in progress. A review of currently available prediction methods was completed. Applicability of the methods to large particle hydrotransport and the prediction of plugging was evaluated. It was determined that available models were inadequate, either because they are empirical and tuned to a given solid or because they are simplified analytical models incapable of accounting for a wide range of parameters. Complicated regression curve fit models lacking a physical basis cannot be extrapolated with confidence. Several specific conclusions were reached: Recent developments in mechanistic modeling, describing flow conditions at the limit of stationary deposition, provide the best basis for prediction and extrapolation of large particle flow. Certain modeled phenomena require further analytical and experimental investigation to improve confidence levels. Experimental work needs to be performed to support modeling and to provide an adequate data base for comparison purposes. No available model permits treatment of solids mixtures such as coal and rock.

  18. Study the ovarian function in Awassi ewes

    International Nuclear Information System (INIS)

    Zarkawi, M.

    1996-03-01

    An experiment was carried out on local Awassi ewes to study the reproductive performance, progesteron concentrations, accuracy of pregnacy diagnosis and other reproduction related criteria of Awassi ewes using radioimunoassay (RIA). A total of 18 nulliparous Awassi ewes, aged about 1 year and weighing on average 36.9 Kg was used. Live-weight changes were recorded weekly. Blood samples (5 ml) were collected from the jugular vein for about 1 year at 10.00h. Sera were prepared and stored at - 20 deg until assyed. The FAO/IAEA progesterone RIA kits were used. Two ewes aborted after about three-and-a-half months of pregnancy due to mechanical reasons. The remaining ewes (16) lambed between 30th November 1994 and 22nd February 1995. Sex ratio was 1:1 (8 males: 8 females). Average birth weights for both sexes was 5210 ± 525 g. Average birth-weight was higher in males than females. Average male birth-weights was 5338 ± 515 g, (4600 - 6000 g) whereas was 5083 ± 538 g, (4180 - 5700 g) for female lambs. Average basal pre-mating progesterone concentration was 0.60 ± 0.42 n mol/l (0-1.7 n mol/l). Average maximum progesterone concentration during the luteal phase in non-pregnant ewes was 11.1 ± 3.1 n mol/l (5.8 -18.00 n mol/l). Average maximum progesterone concentration during gestation was 58.4 ± 20.9 n mol/l (29.25 - 100.00 n mol/l). The accuracy of pregnancy diagnosis at around 21 days post mating using RIA was 100%. It is concluded that RIA could be used for progesterone determination in Awassi sheep successfully, and that more research work on other aspects of reproduction in Awassi sheep should be carried out. (Author). 29 refs., 47 tabs., 5 figs

  19. Child Anxiety Prevention Study: Impact on Functional Outcomes.

    Science.gov (United States)

    Pella, Jeffrey E; Drake, Kelly L; Tein, Jenn-Yun; Ginsburg, Golda S

    2017-06-01

    This study examined the impact of a selective anxiety prevention program for offspring of clinically anxious parents on three domains of child functioning: (1) social, (2) familial, and (3) emotional/behavioral. Dyads were randomized into either the Coping and Promoting Strength program (CAPS; n = 70) or Information Monitoring (IM; n = 66) comparison group. Multi-informant assessments were conducted at baseline, post intervention, and 6 and 12 months follow-ups. Random effects mixed models under the linear growth modeling (LGM) framework was used to assess the impact of CAPS on growth trajectories. Over time, children in the CAPS group had significantly lower anxiety, anxious/depressed symptoms, and lower total behavior problems (parent report), compared to children in IM group. The intervention did not impact other domains assessed (e.g., social functioning), which may be due to "floor effects" on these measures. Longitudinal follow-up data is needed to provide valuable information about this high risk population.

  20. Study on response function of CdTe detector

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyunduk; Cho, Gyuseong [Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701 (Korea, Republic of); Kang, Bo-Sun [Department of Radiological Science, Catholic University of Daegu, Kyoungsan, Kyoungbuk 712-702 (Korea, Republic of)], E-mail: bskang@cu.ac.kr

    2009-10-21

    So far the origin of the mechanism of light emission in the sonoluminescence has not elucidated whether it is due to blackbody radiation or bremsstrahlung. The final goal of our study is measuring X-ray energy spectrum using high-sensitivity cadmium telluride (CdTe) detector in order to obtain information for understanding sonoluminescence phenomena. However, the scope of this report is the measurement of X-ray spectrum using a high-resolution CdTe detector and determination of CdTe detector response function to obtain the corrected spectrum from measured soft X-ray source spectrum. In general, the measured spectrum was distorted by the characteristics of CdTe detector. Monte Carlo simulation code, MCNP, was used to obtain the reference response function of the CdTe detector. The X-ray spectra of {sup 57}Co, {sup 133}Ba, and {sup 241}Am were obtained by a 4x4x1.0(t) mm{sup 3} CdTe detector at room temperature.

  1. Cross Functional Working and Concurrent Engineering – a UK Study

    Directory of Open Access Journals (Sweden)

    H. Williams

    2000-01-01

    Full Text Available This paper reports on the preliminary results of an investigative study into the implementation of concurrent engineering applied to new product development. Concurrent (or Simultaneous engineering is the term commonly given to creating new products using multi-disciplined teams of marketing, design, manufacturing and support functions together with supplier and customers. Such techniques have produced robust, low cost quality products in short concept to market times compared to traditional ones. The research investigated design management practice and performance in a number of organisations across a range of industrial sectors in the UK by means of a questionnaire survey. The results identify the current use of a variety of design practices and methodologies such as different organisational structures, the extent of cross-functional working, the use of design and phase reviews and the use of different technologies. They indicate that companies implementing CE are more successful in time to market performance than those who don’t implement CE. Factors most influencing the successful adoption of CE are design and phase reviews, and, to a lesser extent, the use of multifunctional teams and supplier partnerships.

  2. Elicited Imitation: A Vehicle for Assessing the Language Functioning Level of Echolalic Autistic Children. Final Report 53.8.

    Science.gov (United States)

    Fritsch, Gudrun

    The booklet discusses and reports on a study of elicited imitation as a vehicle for assessing the language-functioning level of echolalic autistic children. An historical overview is presented of the diagnosis of early infantile autism. The question of whether or not early infantile autism is a distinct syndrome is addressed. The theoretical and…

  3. Technical data report : marine acoustics modelling study

    Energy Technology Data Exchange (ETDEWEB)

    Chorney, N.; Warner, G.; Austin, M. [Jasco Applied Sciences, Victoria, BC (Canada)

    2010-07-01

    This study was conducted to predict the ensonification produced by vessel traffic transiting to and from the Enbridge Northern Gateway Project's marine terminal located near Kitimat, British Columbia (BC). An underwater acoustic propagation model was used to model frequency bands from 20 Hz to 5 kHz at a standard depth of 20 metres. The model included bathymetric grids of the modelling area; underwater sound speed as a function of depth; and geo-acoustic profiles based on the stratified composition of the seafloor. The obtained 1/3 octave band levels were then used to determine broadband received sound levels for 4 scenarios along various transit routes: the Langara and Triple Island in Dixon Entrance; the Browning Entrance in Hecate Strait, and Cape St. James in the Queen Charlotte Basin. The scenarios consisted of a tanker transiting at 16 knots, and an accompanying tug boat. Underwater sound level maps for each scenario were presented. 14 refs., 5 tabs., 16 figs.

  4. Vascular Function at Baseline in the Hemodialysis Fistula Maturation Study

    OpenAIRE

    Dember, Laura M.; Imrey, Peter B.; Duess, Mai?Ann; Hamburg, Naomi M.; Larive, Brett; Radeva, Milena; Himmelfarb, Jonathan; Kraiss, Larry W.; Kusek, John W.; Roy?Chaudhury, Prabir; Terry, Christi M.; Vazquez, Miguel A.; Vongpatanasin, Wanpen; Beck, Gerald J.; Vita, Joseph A.

    2016-01-01

    Background End?stage renal disease is accompanied by functional and structural vascular abnormalities. The objective of this study was to characterize vascular function in a large cohort of patients with end?stage renal disease, using noninvasive physiological measurements, and to correlate function with demographic and clinical factors. Methods and Results We analyzed cross?sectional baseline data from the Hemodialysis Fistula Maturation Study, a multicenter prospective observational cohort ...

  5. Belledune area health study : summary report

    International Nuclear Information System (INIS)

    2005-02-01

    The Belledune area has been home to various industrial activities such as mining, smelting, fertilizer plants, battery-recycling plants, gypsum plants, sawmills, and a coal-fired electricity generating facility. These industries have had various types and quantities of emissions over the past 4 decades that may have impacted on the health of people in the area. This report provided details of the Belledune Health Area Study. The objective of the study was to ensure that the concerns of residents were addressed and that the historical and human health risks associated with past and current industrial activities were quantified. The current health status of residents in the area was examined with reference to environmental exposures, and recommendations for future studies and research based on the results of the study were presented. Two main components were used: the human health risk assessment (HHRA), and community health status assessment (CHSA). Best estimate calculations for residents in the core communities showed that exposures to cadmium, lead and mercury were predicted to be below toxicity reference values. In Belledune itself, child exposures to cadmium and mercury were above the toxicity reference value. Results indicated that the health status pattern for the study area was different from that found in the surrounding areas. There was a statistically significantly elevated incidence of oral, respiratory, and prostate cancer and elevated incidences of kidney and colorectal cancer. There was a higher mortality rate than expected, and there were more deaths than expected due to circulatory disease, cancer and other causes such as accidents and suicides. An expanded survey of blood lead among child residents and pregnant women was recommended. A program was launched to collect data on metal concentrations in fish from the Baie des Chaleurs and additional data on vegetables from the Greater Belledune area. Future research on some of the factors associated

  6. Belledune area health study : summary report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-02-01

    The Belledune area has been home to various industrial activities such as mining, smelting, fertilizer plants, battery-recycling plants, gypsum plants, sawmills, and a coal-fired electricity generating facility. These industries have had various types and quantities of emissions over the past 4 decades that may have impacted on the health of people in the area. This report provided details of the Belledune Health Area Study. The objective of the study was to ensure that the concerns of residents were addressed and that the historical and human health risks associated with past and current industrial activities were quantified. The current health status of residents in the area was examined with reference to environmental exposures, and recommendations for future studies and research based on the results of the study were presented. Two main components were used: the human health risk assessment (HHRA), and community health status assessment (CHSA). Best estimate calculations for residents in the core communities showed that exposures to cadmium, lead and mercury were predicted to be below toxicity reference values. In Belledune itself, child exposures to cadmium and mercury were above the toxicity reference value. Results indicated that the health status pattern for the study area was different from that found in the surrounding areas. There was a statistically significantly elevated incidence of oral, respiratory, and prostate cancer and elevated incidences of kidney and colorectal cancer. There was a higher mortality rate than expected, and there were more deaths than expected due to circulatory disease, cancer and other causes such as accidents and suicides. An expanded survey of blood lead among child residents and pregnant women was recommended. A program was launched to collect data on metal concentrations in fish from the Baie des Chaleurs and additional data on vegetables from the Greater Belledune area. Future research on some of the factors associated

  7. Potential Reporting Bias in Neuroimaging Studies of Sex Differences.

    Science.gov (United States)

    David, Sean P; Naudet, Florian; Laude, Jennifer; Radua, Joaquim; Fusar-Poli, Paolo; Chu, Isabella; Stefanick, Marcia L; Ioannidis, John P A

    2018-04-17

    Numerous functional magnetic resonance imaging (fMRI) studies have reported sex differences. To empirically evaluate for evidence of excessive significance bias in this literature, we searched for published fMRI studies of human brain to evaluate sex differences, regardless of the topic investigated, in Medline and Scopus over 10 years. We analyzed the prevalence of conclusions in favor of sex differences and the correlation between study sample sizes and number of significant foci identified. In the absence of bias, larger studies (better powered) should identify a larger number of significant foci. Across 179 papers, median sample size was n = 32 (interquartile range 23-47.5). A median of 5 foci related to sex differences were reported (interquartile range, 2-9.5). Few articles (n = 2) had titles focused on no differences or on similarities (n = 3) between sexes. Overall, 158 papers (88%) reached "positive" conclusions in their abstract and presented some foci related to sex differences. There was no statistically significant relationship between sample size and the number of foci (-0.048% increase for every 10 participants, p = 0.63). The extremely high prevalence of "positive" results and the lack of the expected relationship between sample size and the number of discovered foci reflect probable reporting bias and excess significance bias in this literature.

  8. Life span study report 9, part 3

    International Nuclear Information System (INIS)

    Wakabayashi, Toshiro; Kato, Hiroo; Ikeda, Takayoshi; Schull, W.J.

    1983-04-01

    The incidence of malignant tumors in the RERF Life Span Study (LSS) sample in Nagasaki as revealed by the Nagasaki Tumor Registry (Registry) has been investigated for the period 1959-78. No exposure status bias in data collection has been revealed. Neither method of diagnosis, reporting hospitals, nor the frequency of doubtful cases differ by exposure dose. Thus, the effect of a bias, if one exists, must be small and should not affect the interpretation of the results obtained in the present analysis. The risk of radiogenic cancer definitely increases with radiation dose for leukemia, cancer of the breast, lung, stomach, and thyroid, and suggestively so for cancer of the colon and urinary tract and multiple myeloma. However, there is no increase as yet for cancer of the esophagus, liver, gall bladder, uterus, ovary, and salivary gland, or for malignant lymphoma. For fatal cancers, these results strengthen those of the recent analysis of mortality based on death certificates on the same LSS cohort. In general, the relative risks based on incidence (that is, on Registry data) are either the same or slightly higher than those based on mortality for the same years; however, the absolute risk estimates (excess cancer per million person-year per rad) are far higher. (author)

  9. Task E container corrosion studies: Annual report

    International Nuclear Information System (INIS)

    Bunnell, L.R.; Doremus, L.A.; Topping, J.B.; Duncan, D.R.

    1994-06-01

    The Pacific Northwest Laboratory is conducting the Solid Waste Technology Support Program (SWTSP) for Westinghouse Hanford Company (WHC). Task E is the Container Corrosion Study Portion of the SWTSP that will perform testing to provide defensible data on the corrosion of low-carbon steel, as used in drums to contain chemical and radioactive wastes at the Hanford Site. A second objective of Task E is to provide and test practical alternative materials that have higher corrosion resistance than low-carbon steel. The scope of work for fiscal year (FY) 1993 included initial testing of mild steel specimens buried in Hanford soils or exposed to atmospheric corrosion in metal storage sheds. During FY 1993, progress was made in three areas of Task E. First, exposure of test materials began at the Soil Corrosion Test Site where low-carbon steel specimens were placed in the soil in five test shafts at depths of 9 m (30 ft). Second, the corrosion measurement of low-carbon steel in the soil of two solid waste trenches continued. The total exposure time is ∼ 500 days. Third, an atmospheric corrosion test of low-carbon steel was put initiated in a metal shed (Building 2401-W) in the 200 West Area. This annual report describes the Task E efforts and provides a current status

  10. Quality of reporting of diagnostic accuracy studies

    NARCIS (Netherlands)

    Smidt, N.; Rutjes, A.W.; Windt - Mens, van der D.A.W.M.; Ostelo, R.W.J.G.; Reitsma, J.B.; Bouter, L.M.; Vet, de H.C.W.

    2005-01-01

    PURPOSE: To evaluate quality of reporting in diagnostic accuracy articles published in 2000 in journals with impact factor of at least 4 by using items of Standards for Reporting of Diagnostic Accuracy (STARD) statement published later in 2003. MATERIALS AND METHODS: English-language articles on

  11. Catalyst Schools Research Study: Technical Report

    Science.gov (United States)

    Hammer, Patricia Cahape

    2016-01-01

    In January 2012, the West Virginia Governor's Office released an influential report, "Education Efficiency Audit of West Virginia's Primary and Secondary Education System," written by Public Works (2012), a management consulting company headquartered in West Chester, Pennsylvania. Based largely on this report, the West Virginia…

  12. Self-reported dietary intake of omega-3 fatty acids and association with bone and lower extremity function.

    Science.gov (United States)

    Rousseau, James H; Kleppinger, Alison; Kenny, Anne M

    2009-10-01

    To assess the relationship between self-reported omega-3 fatty acid (O3FA) intake and bone mineral density (BMD) and lower extremity function in older adults. Cross-sectional analysis of baseline information from three separate ongoing studies of older adults, pooled for this analysis. Academic health center. Two hundred forty-seven men (n=118) and women (n=129) residing in the community or an assisted living facility. Self-reported dietary intake (O3FA, omega-6 fatty acids (O6FA), protein, and total calorie); BMD of the hip or heel; and lower extremity function including leg strength, chair rise time, walking speed, Timed Up and Go, and frailty. The mean reported intake of O3FA was 1.27 g/day. Correlation coefficients (r) between O3FA and T-scores from total femur (n=167) were 0.210 and 0.147 for combined femur and heel T scores. Similar correlations were found for leg strength (r=0.205) and chair rise time (r=-0.178), but the significance was lost when corrected for protein intake. Subjects with lower reported O3FA intake (<1.27 g/day) had lower BMD than those with higher reported O3FA intake. In a multiple regression analysis with femoral neck BMD as the dependent variable and reported intake of O3FA, O6FA, protein, and vitamin D as independent variables, reported O3FA intake was the only significant variable, accounting for 6% of the variance in BMD. Older adults had low reported intakes of O3FA. There was an association between greater reported O3FA intake and higher BMD. There was no independent association between reported O3FA intake and lower extremity function. Results from this preliminary report are promising and suggest further investigation.

  13. Functional Recovery in Chronic Stage of Spinal Cord Injury by Neurorestorative Approach: A Case Report

    Directory of Open Access Journals (Sweden)

    Alok Sharma

    2014-01-01

    Full Text Available Spinal cord injury (SCI at an early age can be debilitating for the child’s growth. Current treatments show a level of stagnancy, after which the recovery is minimal. Cellular therapy is an emerging area of research and has been found to possess many benefits in the previous studies. Transplantation of autologous bone marrow mononuclear cells (BMMNCs has demonstrated therapeutic potential for many neurological conditions, including spinal cord injury. Here we report a case of 6-year-old girl with traumatic SCI at the level of C7-D1 4 years back, who underwent 2 doses of cell transplantation with autologous BMMNCs with an interval of 6 months along with standard rehabilitation. The patient did not have any major or minor side effects. The patient showed clinical improvements throughout the 6 months after transplantation, which was assessed using Functional Independence Measure (before: 82, after: 101 out of 126. There were patchy areas of sensory gain in bilateral feet recorded, with improvements in the bladder sensation and control. Improved gait was seen as a result of better strength in abdominals and back extensors. The fact that there was functional improvement in the chronic plateau phase indicates the potential of cell therapy in chronic SCI. Further clinical studies are warranted.

  14. Recommendations for a Standardized Pulmonary Function Report. An Official American Thoracic Society Technical Statement.

    Science.gov (United States)

    Culver, Bruce H; Graham, Brian L; Coates, Allan L; Wanger, Jack; Berry, Cristine E; Clarke, Patricia K; Hallstrand, Teal S; Hankinson, John L; Kaminsky, David A; MacIntyre, Neil R; McCormack, Meredith C; Rosenfeld, Margaret; Stanojevic, Sanja; Weiner, Daniel J

    2017-12-01

    The American Thoracic Society committee on Proficiency Standards for Pulmonary Function Laboratories has recognized the need for a standardized reporting format for pulmonary function tests. Although prior documents have offered guidance on the reporting of test data, there is considerable variability in how these results are presented to end users, leading to potential confusion and miscommunication. A project task force, consisting of the committee as a whole, was approved to develop a new Technical Standard on reporting pulmonary function test results. Three working groups addressed the presentation format, the reference data supporting interpretation of results, and a system for grading quality of test efforts. Each group reviewed relevant literature and wrote drafts that were merged into the final document. This document presents a reporting format in test-specific units for spirometry, lung volumes, and diffusing capacity that can be assembled into a report appropriate for a laboratory's practice. Recommended reference sources are updated with data for spirometry and diffusing capacity published since prior documents. A grading system is presented to encourage uniformity in the important function of test quality assessment. The committee believes that wide adoption of these formats and their underlying principles by equipment manufacturers and pulmonary function laboratories can improve the interpretation, communication, and understanding of test results.

  15. Oral health status and self-reported functional dependence in community-dwelling older adults.

    Science.gov (United States)

    Yu, Yau-Hua; Lai, Yu-Lin; Cheung, Wai S; Kuo, Hsu-Ko

    2011-03-01

    To assess the strength of association between graded groups of oral health status and self-reported functional dependence in community-dwelling older adults. Population-based cross-sectional study. National Health and Nutritional Examination Survey (NHANES) 1999 to 2004. Three thousand eight hundred fifty-six participants aged 60 and older (mean age 71.2) without missing values in the examined correlates. Oral health status was evaluated according to edentulism, severity of periodontal disease, and recommendation of periodontal care and compared with that of healthy controls. Self-reported functional dependence was assessed according to 19 questions in five domains: activities of daily living (ADLs), instrumental activities of daily living (IADLs), leisure and social activities (LSAs), lower extremity mobility (LEM), and general physical activities (GPAs). After controlling for demographic and dental variables, health-related behaviors, C-reactive protein, and comorbidities, edentulism was significantly associated with disability in IADLs (odds ratio (OR)=1.58), LSAs (OR=1.63), LEM (OR=1.31), and GPAs (OR=1.45) compared with healthy controls. Likewise, severe periodontitis was associated with disability in IADLs (OR=1.58), LSAs (OR=1.70), and LEM (OR=1.63). The trends toward disability in IADLs, LSAs, LEM, and GPAs were statistically significant across increasing severity of oral health problems. Poor oral health, specifically edentulism and severe periodontitis, is associated with multiple domains of late-life disability, but a causal relationship cannot be established based on current study design. © 2011, Copyright the Authors. Journal compilation © 2011, The American Geriatrics Society.

  16. Cognitive function after pre-eclampsia: an explorative study.

    NARCIS (Netherlands)

    Baecke, M.; Spaanderman, M.E.A.; Werf, S.P. van der

    2009-01-01

    BACKGROUND: Pre-eclampsia and eclampsia relate to cerebral damage. Memory and concentration problems are frequently reported after these pregnancy-related vascular complications. We tested the hypothesis that in formerly pre-eclamptic women cognitive functioning is impaired as compared with healthy

  17. Driving with Mild Cognitive Impairment or Dementia: Cognitive Test Performance and Proxy Report of Daily Life Function in Older Women.

    Science.gov (United States)

    Vaughan, Leslie; Hogan, Patricia E; Rapp, Stephen R; Dugan, Elizabeth; Marottoli, Richard A; Snively, Beverly M; Shumaker, Sally A; Sink, Kaycee M

    2015-09-01

    To investigate associations between proxy report of cognitive and functional limitations and cognitive performance and current or former driving status in older women with mild cognitive impairment (MCI) and all-cause dementia. Cross-sectional data analysis of retrospectively identified older women with adjudicated MCI and all-cause dementia in the Women's Health Initiative Memory Study-Epidemiology of Cognitive Health Outcomes (WHIMS-ECHO). Academic medical center. Women (mean age ± standard deviation 83.7 ± 3.5) adjudicated with MCI or dementia during Year 1, 2, 3, or 4 of the WHIMS-ECHO follow-up period (N = 385). The telephone-administered cognitive battery included tests of attention, verbal learning and memory, verbal fluency, executive function, working memory, and global cognitive function plus self-report measures of depressive symptomatology. The Dementia Questionnaire (DQ) was administered to a knowledgeable proxy (family member, friend). Sixty percent of women with MCI and 40% of those with dementia are current drivers. Proxy reports of functional limitations in instrumental activities of daily living (IADLs) are associated with current driving status in women with MCI, whereas performance-based cognitive tests are not. In women with dementia, proxy reports of functional limitations in IADLs and performance-based cognitive tests are associated with current driving status, as expected. These findings have clinical implications for the importance of evaluating driving concurrently with other instrumental functional abilities in MCI and dementia. Additional work is needed to determine whether proxy report of cognitive and functional impairments should help guide referrals for driving assessment and rehabilitation or counseling for driving transition. © 2015, Copyright the Authors Journal compilation © 2015, The American Geriatrics Society.

  18. Standardized reporting of functioning information on ICF-based common metrics.

    Science.gov (United States)

    Prodinger, Birgit; Tennant, Alan; Stucki, Gerold

    2018-02-01

    In clinical practice and research a variety of clinical data collection tools are used to collect information on people's functioning for clinical practice and research and national health information systems. Reporting on ICF-based common metrics enables standardized documentation of functioning information in national health information systems. The objective of this methodological note on applying the ICF in rehabilitation is to demonstrate how to report functioning information collected with a data collection tool on ICF-based common metrics. We first specify the requirements for the standardized reporting of functioning information. Secondly, we introduce the methods needed for transforming functioning data to ICF-based common metrics. Finally, we provide an example. The requirements for standardized reporting are as follows: 1) having a common conceptual framework to enable content comparability between any health information; and 2) a measurement framework so that scores between two or more clinical data collection tools can be directly compared. The methods needed to achieve these requirements are the ICF Linking Rules and the Rasch measurement model. Using data collected incorporating the 36-item Short Form Health Survey (SF-36), the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0), and the Stroke Impact Scale 3.0 (SIS 3.0), the application of the standardized reporting based on common metrics is demonstrated. A subset of items from the three tools linked to common chapters of the ICF (d4 Mobility, d5 Self-care and d6 Domestic life), were entered as "super items" into the Rasch model. Good fit was achieved with no residual local dependency and a unidimensional metric. A transformation table allows for comparison between scales, and between a scale and the reporting common metric. Being able to report functioning information collected with commonly used clinical data collection tools with ICF-based common metrics enables clinicians

  19. Laser fusion study. Final report, volume I, study results

    International Nuclear Information System (INIS)

    1975-06-01

    The primary goal of this study was to devise, evaluate, and conceptually design a complete, end-to-end, alignment system capable of handling 30 to 32 Shiva amplifier chains to specified accuracies in space and time. A secondary goal was to accomplish the primary goal with an acceptably low development and procurement cost and with an acceptably high day-after-day performance reliability. This report presents such a system: it is comprised of sensors, actuating mechanisms, controls, and displays that perform well within the current art-state. (U.S.)

  20. Functional limitations as potential mediators of the effects of self-reported vision status on fall risk of older adults.

    Science.gov (United States)

    Steinman, Bernard A; Allen, Susan M; Chen, Jie; Pynoos, Jon

    2015-02-01

    To test whether limitations in mobility and large-muscle functioning mediate self-reported vision status to increase fall risk among respondents age 65 and above. This study used two waves from the Health and Retirement Study. We conducted binary logistic and negative binomial regression analyses to test indirect paths leading from self-reported vision status to falls, via indices of mobility and large-muscle functioning. Limited evidence was found for a mediating effect among women; however, large-muscle groups were implicated as partially mediating risk factors for falls among men with fair self-reported vision status. Implications of these findings are discussed including the need for prioritizing improved muscle strength of older men and women with poor vision as a preventive measure against falls. © The Author(s) 2014.

  1. Examples and Case Studies for the 2012 Chemical Data Reporting

    Science.gov (United States)

    This document presents examples and case studies to help you in reporting for 2012 Chemical Data Reporting (CDR), formerly known as Inventory Update Reporting (IUR).EPA designed these examples to illustrate the new reporting requirements, which were published as part of the CDR Rule (published August 16, 2011), and to address general reporting issues from the 2006 IUR.

  2. Next Generation Melter Optioneering Study - Interim Report

    International Nuclear Information System (INIS)

    Gray, M.F.; Calmus, R.B.; Ramsey, G.; Lomax, J.; Allen, H.

    2010-01-01

    The next generation melter (NOM) development program includes a down selection process to aid in determining the recommended vitrification technology to implement into the WTP at the first melter change-out which is scheduled for 2025. This optioneering study presents a structured value engineering process to establish and assess evaluation criteria that will be incorporated into the down selection process. This process establishes an evaluation framework that will be used progressively throughout the NGM program, and as such this interim report will be updated on a regular basis. The workshop objectives were achieved. In particular: (1) Consensus was reached with stakeholders and technology providers represented at the workshop regarding the need for a decision making process and the application of the D 2 0 process to NGM option evaluation. (2) A framework was established for applying the decision making process to technology development and evaluation between 2010 and 2013. (3) The criteria for the initial evaluation in 2011 were refined and agreed with stakeholders and technology providers. (4) The technology providers have the guidance required to produce data/information to support the next phase of the evaluation process. In some cases it may be necessary to reflect the data/information requirements and overall approach to the evaluation of technology options against specific criteria within updated Statements of Work for 2010-2011. Access to the WTP engineering data has been identified as being very important for option development and evaluation due to the interface issues for the NGM and surrounding plant. WRPS efforts are ongoing to establish precisely data that is required and how to resolve this Issue. It is intended to apply a similarly structured decision making process to the development and evaluation of LAW NGM options.

  3. Life span study report 10 - 1

    International Nuclear Information System (INIS)

    Preston, D.L.; Kato, Hiroo; Kopecky, K.J.; Fujita, Shoichiro.

    1987-08-01

    The present study extends the previous report on cancer mortality among atomic bomb survivors by adding data from four additional years of follow-up (1979 - 82) and by expanding the cohort (now designated LSS-E85) to include 11,393 Nagasaki survivors located between 2,500 - 9,999 m from the hypocenter at the time of the bombing (ATB). Significant dose responses were observed for leukemia, for cancers of the lung, female breast, stomach, colon, esophagus, and urinary bladder, and for multiple myeloma. Four new categories of cancer were also investigated: the results for cancers of the liver and intrahepatic bile ducts and of the ovary and other uterine adnexa were suggestive of significant radiation effects, but the positive dose responses for cancers of the gallbladder and prostate were not significant. Due to diagnostic difficulties and the lack of evidence for radiogenic effects at these sites, the results for liver and ovarian cancers do not provide convincing evidence for radiogenic effects. With the exception of multiple myeloma, the relative risk (RR) of radiation-induced cancer mortality was greater for women than for men, for each nonleukemic cancer with a significant overall dose response. These differences can be attributed in large measure to differences in the background cancer mortality rates, which are generally much higher for men than women. For leukemia there was no significant sex difference in the RR, while for multiple myeloma women had a slightly, though nonsignificantly, lower RR than males. A statistically significant interaction (p = .008) between the effects of age ATB and attained age on radiation-related mortality was also observed for cancers other than leukemia. In particular, the initially large RRs seen in those who were young ATB have decreased with time, while the smaller RRs for those who were older ATB tended to increase. (author)

  4. Fusion breeder studies program: Final report

    International Nuclear Information System (INIS)

    Berwald, D.H.

    1986-01-01

    This report is an assessment of technology related to hybrid reactors, especially the Fission-suppressed hybrid. A description of a typical fission-suppressed reactor is given. The economic advantages of the use of a hybrid reactor as part of a fuel cycle center are discussed at length. The inherent safety advantages of the hybrid reactor are analyzed. The report concludes with a proposed timetable for research and development

  5. Imaging tools to study pharmacology: functional MRI on small rodents

    OpenAIRE

    Elisabeth eJonckers; Disha eShah; Julie eHamaide; Marleen eVerhoye; Annemie eVan Der Linden

    2015-01-01

    Functional Magnetic Resonance Imaging (fMRI) is an excellent tool to study the effect of pharmacological modulations on brain function in a non-invasive and longitudinal manner. We introduce several blood oxygenation level dependent (BOLD) fMRI techniques, including resting state (rsfMRI), stimulus-evoked (st-fMRI), and pharmacological MRI (phMRI). Respectively, these techniques permit the assessment of functional connectivity during rest as well as brain activation triggered by sensory stimu...

  6. Activated and deactivated functional brain areas in the Deqi state: A functional MRI study.

    Science.gov (United States)

    Huang, Yong; Zeng, Tongjun; Zhang, Guifeng; Li, Ganlong; Lu, Na; Lai, Xinsheng; Lu, Yangjia; Chen, Jiarong

    2012-10-25

    We compared the activities of functional regions of the brain in the Deqi versus non-Deqi state, as reported by physicians and subjects during acupuncture. Twelve healthy volunteers received sham and true needling at the Waiguan (TE5) acupoint. Real-time cerebral functional MRI showed that compared with non-sensation after sham needling, true needling activated Brodmann areas 3, 6, 8, 9, 10, 11, 13, 20, 21, 37, 39, 40, 43, and 47, the head of the caudate nucleus, the parahippocampal gyrus, thalamus and red nucleus. True needling also deactivated Brodmann areas 1, 2, 3, 4, 5, 6, 7, 9, 10, 18, 24, 31, 40 and 46.

  7. Aspects of studies on the functional impairment electrohypersensitivity

    Energy Technology Data Exchange (ETDEWEB)

    Johansson, Olle, E-mail: olle.johansson@ki.s [Experimental Dermatology Unit, Department of Neuroscience, Karolinska Institute, 171 77 Stockholm (Sweden); Royal Institute of Technology, 100 44 Stockholm (Sweden)

    2010-04-15

    Persons, claiming to suffer from exposure to electromagnetic fields, have been described in the literature. In Sweden, electrohypersensitivity (EHS) is an officially fully recognized functional impairment (i.e., it is not regarded as a disease). Survey studies show that somewhere between 230,000 - 290,000 Swedish men and women - out of a population of 9,000,000 - report a variety of symptoms when being in contact with electromagnetic field (EMF) sources. Swedish electrohypersensitive people have their own handicap organization, The Swedish Association for the Electrohypersensitive, which has its own website in both Swedish and English. This organization is included in the Swedish Disability Federation (Handikappfoerbundens SamarbetsOrgan; HSO). One aim of our studies has been to investigate possible alterations, in the cellular and neuronal systems of these persons' skin. In summary, it is evident from our preliminary data that various alterations are present in the electrohypersensitive persons' skin that are not indicated in the skin of normal healthy volunteers.

  8. [Functional Neuroimaging Pilot Study of Borderline Personality Disorder in Adolescents].

    Science.gov (United States)

    LeBoeuf, Amélie; Guilé, Jean-Marc; Labelle, Réal; Luck, David

    Borderline personality disorder (BPD) is being increasingly recognized by clinicians working with adolescents, and the reliability and validity of the diagnosis have been established in the adolescent population. Adolescence is known to be a period of high risk for BPD development as most patients identify the onset of their symptoms to be in the adolescent period. As with other mental health disorders, personality disorder, are thought to result from the interaction between biological and environmental factors. Functional neuroimaging studies are reporting an increasing amount of data on abnormal neuronal functions in BPD adult patients. However, no functional neuroimaging studies have been conducted in adolescents with BPD.Objectives This pilot project aims to evaluate the feasibility of a functional magnetic resonance imaging (fMRI) study coupled with clinical and psychological measures in adolescent girls with a diagnosis of BPD. It also aims to identify neuronal regions of interest (ROI) for the study of BPD in adolescent girls.Method Six female adolescents meeting DSM-IV criteria for BPD and 6 female adolescents without psychiatric disorder were recruited. Both groups were evaluated for BPD symptoms, depressive symptoms, impulsivity, affective lability, and other potential psychiatric comorbidities. We used fMRI to compare patterns of regional brain activation between these two groups as they viewed 20 positive, 20 negative and 20 neutral emotion-inducing pictures, which were presented in random order.Results Participants were recruited over a period of 22 months. The protocol was well tolerated by participants. Mean age of the BPD group and control group was 15.8 ± 0.9 years-old and 15.5 ± 1.2 years-old respectively. Psychiatric comorbidity and use of medication was common among participants in the BPD group. This group showed higher impulsivity and affective lability scores. For the fMRI task, BPD patients demonstrated greater differences in activation

  9. Graphene on metals: A van der Waals density functional study

    DEFF Research Database (Denmark)

    Vanin, Marco; Mortensen, Jens Jørgen; Kelkkanen, Kari André

    2010-01-01

    We use density functional theory (DFT) with a recently developed van der Waals density functional (vdW-DF) to study the adsorption of graphene on Co, Ni, Pd, Ag, Au, Cu, Pt, and Al(111) surfaces. In contrast to the local-density approximation (LDA) which predicts relatively strong binding for Ni...

  10. Isotopic study of liver function after narcosis in small animals

    International Nuclear Information System (INIS)

    Le Qui Cuong; Kiss, Bela; Jakab, Tivadar; Szilvasi, Istvan; Spett, Borbala

    1984-01-01

    Dinamic functional study of the liver was performed by sup(99m)Tc-TECHIDA in narcotized (Halothane) mice and rabbits. Hepatic uptake of the radiopharmaceutical decreased in narcotized group significantly. Excretion also decreased but statistically insignificantly. These alterations in the liver function could be attributed to the hypotensive effect of Halothane. (author)

  11. OEXP exploration studies technical report. Volume 3: Special reports, studies, and indepth systems assessments

    International Nuclear Information System (INIS)

    Roberts, B.B.; Bland, D.

    1988-12-01

    The Office of Exploration (OEXP) at NASA has been tasked with defining and recommending alternatives for an early 1990's national decision on a focused program of manned exploration of the Solar System. The Mission analysis and System Engineering (MASE) group, which is managed by the Exploration Studies Office at the Johnson Space Center, is responsible for coordinating the technical studies necessary for accomplishing such a task. This technical report, produced by the MASE, describes the process used to conduct exploration studies and discusses the mission developed in a case study approach. The four case studies developed in FY88 include: (1) a manned expedition to PHOBOS; (2) a manned expedition to MARS; (3) a lunar surface observatory; and a lunar outpost to early Mars evolution. The final outcome of this effort is a set of programmatic and technical conclusions and recommendations for the following year's work

  12. SANS-polymer and functional materials with neutron in Indonesia. Progress report on the collaboration activities?

    International Nuclear Information System (INIS)

    Ikram, A.; Gunawan; Sukirman, E.; Ridwan; Jahja, A.K.

    2000-01-01

    Activities on SANS-polymer collaboration program are reported. This paper presents SANS-data from Sodium Dodecyl Sulphate that have been obtained using BATAN's SANS machine in Serpong. Reports are also presented about activities in the groups for functional materials structural determination which includes magnetic, HTc superconducting and superionic conducting materials. Discussions are also given towards the way the collaboration activities were carried out in the last three years as well as impact of neutron scattering facility conditions in Indonesia. (author)

  13. Clinical Case Reporting in the Peer-Reviewed Physical Therapy Literature: Time to Move Toward Functioning.

    Science.gov (United States)

    Davenport, Todd E

    2015-12-01

    Physical therapists increasingly are contributing clinical case reports to the health literature, which form the basis for higher quality evidence that has been incorporated into clinical practice guidelines. Yet, few resources exist to assist physical therapists with the basic mechanics and quality standards of producing a clinical case report. This situation is further complicated by the absence of uniform standards for quality in case reporting. The importance of including a concise yet comprehensive description of patient functioning in all physical therapy case reports suggest the potential appropriateness of basing quality guidelines on the World Health Organization's International Classification of Functioning Disability and Health (ICF) model. The purpose of this paper is to assist physical therapists in creating high-quality clinical case reports for the peer-reviewed literature using the ICF model as a guiding framework. Along these lines, current recommendations related to the basic mechanics of writing a successful clinical case report are reviewed, as well and a proposal for uniform clinical case reporting requirements is introduced with the aim to improve the quality and feasibility of clinical case reporting in physical therapy that are informed by the ICF model. Copyright © 2013 John Wiley & Sons, Ltd.

  14. SERT Transformation Study. Technical Report No. 70.

    Science.gov (United States)

    Day, Richard; And Others

    This research report deals with the transformations of stimulus sentences that primary grade speakers of Hawaii Creole English (HCE) made when they were asked to repeat sentences said to them in Standard English. The test used was the Kamehameha Early Education Program (KEEP) Standard English Repetition Test (SERT) which was administered to the 21…

  15. Neutral beam source commercialization study. Final report

    International Nuclear Information System (INIS)

    King, H.J.

    1980-06-01

    The basic tasks of this Phase II project were to: generate a set of design drawings suitable for quantity production of sources of this design; fabricate a functional neutral beam source incorporating as many of the proposed design changes as proved feasible; and document the procedures and findings developed during the contract. These tasks have been accomplished and represent a demonstrated milestone in the industrialization of this complete device

  16. Introductory study of brain function data processing; No kino joho shori no sendo kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    An investigational study was conducted of the brain function aiming at developing an interface with the same function as humans have. In the study, the most up-to-date information/knowledge and future problems were examined on brain measurement, brain modeling, making a model an element, and the brain function data processing system. As to the brain measurement, the paper took up the multielectrode simultaneous measuring method and the optical multipoint measuring method as an invasive measuring method, and the functional magnetic resonance imaging, near-infrared spectroscopy, magneto-encephalography, and electro-encephalography as a non-invasive measuring method. Relating to the brain modeling, studies were made on senses of sight and smell, the movement control and the learning. As to making a model an element, how to make the modeled function a chip on silicone for example becomes the problem. Reported were two reports on making the sense of sight an element and one report on making the parallel dispersed processing mechanism of brain an element. About the brain function data processing system, three reports were made on the present situation, matters in question, and the future development of the system in the case of catching data processing as a system taking a step ahead from making the model an element. 250 refs., 74 figs., 11 tabs.

  17. Associations Between the Self-Reported Frequency of Hearing Chemical Alarms in Theater and Visuospatial Function in Gulf War Veterans.

    Science.gov (United States)

    Chao, Linda L

    2016-10-01

    The aim of this study was to examine the relationship between the self-reported frequencies of hearing chemical alarms during deployment and visuospatial function in Gulf War (GW) veterans. The relationship between the self-reported frequency of hearing chemical alarms, neurobehavioral, and volumetric brain imaging data was examined with correlational, regression, and mediation analyses. The self-reported frequency of hearing chemical alarms was inversely associated with and significantly predicted performance on a visuospatial task (ie, Block Design) over and above potentially confounding variables, including concurrent, correlated GW-related exposures. This effect was partially mediated by the relationship between hearing chemical alarms and lateral occipital cortex volume. Exposure to substances that triggered chemical alarms during GW deployment likely had adverse effects on veterans' brain structure and function, warranting further investigation of whether these GW veterans are at an increased risk for dementia.

  18. Objective effect manifestation of pectus excavatum on load-stressed pulmonary function testing: a case report

    Directory of Open Access Journals (Sweden)

    Chan Jason

    2011-12-01

    Full Text Available Abstract Introduction Pectus excavatum is the most common congenital deformity of the anterior chest wall that, under certain conditions, may pose functional problems due to cardiopulmonary compromise and exercise intolerance. Case presentation We present the case of an otherwise physically-adept 21-year-old Chinese sportsman with idiopathic pectus excavatum, whose symptoms manifested only on bearing a loaded body vest and backpack during physical exercise. Corroborative objective evidence was obtained via load-stressed pulmonary function testing, which demonstrated restrictive lung function. Conclusion This report highlights the possible detrimental synergism of thoracic load stress and pectus excavatum on cardiopulmonary function. Thoracic load-stressed pulmonary function testing provides objective evidence in support of such a synergistic relationship.

  19. Neurobehavioral Performance Impairment in Insomnia: Relationships with Self-Reported Sleep and Daytime Functioning

    Science.gov (United States)

    Shekleton, Julia A.; Flynn-Evans, Erin E.; Miller, Belinda; Epstein, Lawrence J.; Kirsch, Douglas; Brogna, Lauren A.; Burke, Liza M.; Bremer, Erin; Murray, Jade M.; Gehrman, Philip; Lockley, Steven W.; Rajaratnam, Shantha M. W.

    2014-01-01

    Study Objectives: Despite the high prevalence of insomnia, daytime consequences of the disorder are poorly characterized. This study aimed to identify neurobehavioral impairments associated with insomnia, and to investigate relationships between these impairments and subjective ratings of sleep and daytime dysfunction. Design: Cross-sectional, multicenter study. Setting: Three sleep laboratories in the USA and Australia. Patients: Seventy-six individuals who met the Research Diagnostic Criteria (RDC) for Primary Insomnia, Psychophysiological Insomnia, Paradoxical Insomnia, and/or Idiopathic Childhood Insomnia (44F, 35.8 ± 12.0 years [mean ± SD]) and 20 healthy controls (14F, 34.8 ± 12.1 years). Interventions: N/A. Measurements and Results: Participants completed a 7-day sleep-wake diary, questionnaires assessing daytime dysfunction, and a neurobehavioral test battery every 60-180 minutes during an afternoon/evening sleep laboratory visit. Included were tasks assessing sustained and switching attention, working memory, subjective sleepiness, and effort. Switching attention and working memory were significantly worse in insomnia patients than controls, while no differences were found for simple or complex sustained attention tasks. Poorer sustained attention in the control, but not the insomnia group, was significantly associated with increased subjective sleepiness. In insomnia patients, poorer sustained attention performance was associated with reduced health-related quality of life and increased insomnia severity. Conclusions: We found that insomnia patients exhibit deficits in higher level neurobehavioral functioning, but not in basic attention. The findings indicate that neurobehavioral deficits in insomnia are due to neurobiological alterations, rather than sleepiness resulting from chronic sleep deficiency. Citation: Shekleton JA; Flynn-Evans EE; Miller B; Epstein LJ; Kirsch D; Brogna LA; Burke LM; Cremer E; Murray JM; Gehrman P; Lockley SW; Rajaratnam SMW

  20. Establishment of frame image in dynamic function renal studies

    International Nuclear Information System (INIS)

    Guedes, Germano P.; Brunetto, Sergio Q.

    1996-01-01

    Statistical procedures applied to a set of images of renal function study are described to define a region of interest (ROI) on the kidneys's contours. The kidneys geometry is considered to adapt to the emitting area in every frames

  1. [Pituitary function of dysgenesic femal rats. Studies with grafting method].

    Science.gov (United States)

    Vanhems, E; Busquet, J

    1975-01-01

    Misulban administered to pregnant rats on the 15th day of gestation provoked gonadal dysgenesia in the offspring. Study of the pituitary function of dysgenesic female rats, realized by grafting method, showed gonadotrophic hypersecretion.

  2. A dysphoric's TALE: The relationship between the self-reported functions of autobiographical memory and symptoms of depression.

    Science.gov (United States)

    Grace, Lydia; Dewhurst, Stephen A; Anderson, Rachel J

    2016-10-01

    Autobiographical memory (AM) is believed to serve self, social and directive functions; however, little is known regarding how this triad of functions operates in depression. Using the Thinking About Life Experiences questionnaire [Bluck, S., & Alea, N. (2011). Crafting the TALE: Construction of a measure to assess the functions of autobiographical remembering. Memory, 19, 470-486.; Bluck, S., Alea, N., Habermas, T., & Rubin, D. C. (2005). A TALE of three functions: The self-reported uses of autobiographical memory. Social Cognition, 23, 91-117.], two studies explored the relationship between depressive symptomology and the self-reported frequency and usefulness of AMs for self, social and directive purposes. Study 1 revealed that thinking more frequently but talking less frequently about past life events was significantly associated with higher depression scores. Recalling past events more frequently to maintain self-continuity was also significantly associated with higher depressive symptomology. However, results from Study 2 indicated that higher levels of depression were also significantly associated with less-frequent useful recollections of past life events for self-continuity purposes. Taken together, the findings suggest atypical utilisations of AM to serve self-continuity functions in depression and can be interpreted within the wider context of ruminative thought processes.

  3. Study on autonomous decentralized-cooperative function monitoring system

    International Nuclear Information System (INIS)

    Matsuoka, Takeshi; Numano, Masayoshi; Someya, Minoru; Fukuto, Junji; Mitomo, Nobuo; Miyazaki, Keiko; Matsukura, Hiroshi

    1998-01-01

    In this study, on a base of result of a nuclear substrate cross-over study on 'Artificial intelligence for nuclear plant' promoted by 5 years plan since 1989 fiscal year, further developed studies are conducted. The studies are promoted by next 5 years plan on following 6 items: (1) Study on stratified expression technique of autonomous function. (2) Study on expression technique of motion state in decentralized-cooperative function. (3) Study on expression technique of decision making process. (4) Integration to operation control system. (5) Integration to maintenance system. And, (6) Comprehensive evaluation experiment. In 1996 fiscal year, improvement and investigation on automatic classification function of plant state were executed. And, preparation of development environment for expression of robot group motion state was conducted. Furthermore, communication experiment using network to realize integration to operation control and maintenance systems and periodical meetings with other institutes were conducted. (G.K.)

  4. Differential Reporting of Adolescent Stress as a Function of Maternal Depression History.

    Science.gov (United States)

    Daryanani, Issar; Hamilton, Jessica L; Shapero, Benjamin G; Burke, Taylor A; Abramson, Lyn Y; Alloy, Lauren B

    The depression-distortion hypothesis posits that depressed mothers report child characteristics in a negatively-biased manner, motivating research on discrepant reporting between depressed mothers and their children. However, the literature has predominately focused on report discrepancies of youth psychopathological and behavioral outcomes, with limited focus on youth stress despite the marked increase of stressful events during adolescence. The current study investigated whether the presence versus absence of a maternal history of major depressive disorder differentially influenced reporting of adolescent stress when compared to her child's report, utilizing a community sample of diverse adolescents. As hypothesized, mothers with a history of depression were more likely to report more youth stress than their children reported. Specifically, mothers with a history of depression were more likely than nondepressed mothers to report more familial, social, and youth-dependent stressors relative to their children; nondepressed mothers were more likely to report less independent stressors than their children.

  5. Effect of a 6-week dynamic neuromuscular training programme on ankle joint function: A Case report

    Directory of Open Access Journals (Sweden)

    O'Driscoll Jeremiah

    2011-06-01

    Full Text Available Abstract Background Ankle joint sprain and the subsequent development of chronic ankle instability (CAI are commonly encountered by clinicians involved in the treatment and rehabilitation of musculoskeletal injuries. It has recently been advocated that ankle joint post-sprain rehabilitation protocols should incorporate dynamic neuromuscular training to enhance ankle joint sensorimotor capabilities. To date no studies have reported on the effects of dynamic neuromuscular training on ankle joint positioning during landing from a jump, which has been reported as one of the primary injury mechanisms for ankle joint sprain. This case report details the effects of a 6-week dynamic neuromuscular training programme on ankle joint function in an athlete with CAI. Methods The athlete took part in a progressive 6-week dynamic neuromuscular training programme which incorporated postural stability, strengthening, plyometric, and speed/agility drills. The outcome measures chosen to assess for interventional efficacy were: 1 Cumberland Ankle Instability Tool (CAIT scores, 2 Star Excursion Balance Test (SEBT reach distances, 3 ankle joint plantar flexion during drop landing and drop vertical jumping, and 4 ground reaction forces (GRFs during walking. Results CAIT and SEBT scores improved following participation in the programme. The angle of ankle joint plantar flexion decreased at the point of initial contact during the drop landing and drop vertical jumping tasks, indicating that the ankle joint was in a less vulnerable position upon landing following participation in the programme. Furthermore, GRFs were reduced whilst walking post-intervention. Conclusions The 6-week dynamic neuromuscular training programme improved parameters of ankle joint sensorimotor control in an athlete with CAI. Further research is now required in a larger cohort of subjects to determine the effects of neuromuscular training on ankle joint injury risk factors.

  6. Dreaming as mind wandering: evidence from functional neuroimaging and first-person content reports.

    Science.gov (United States)

    Fox, Kieran C R; Nijeboer, Savannah; Solomonova, Elizaveta; Domhoff, G William; Christoff, Kalina

    2013-01-01

    Isolated reports have long suggested a similarity in content and thought processes across mind wandering (MW) during waking, and dream mentation during sleep. This overlap has encouraged speculation that both "daydreaming" and dreaming may engage similar brain mechanisms. To explore this possibility, we systematically examined published first-person experiential reports of MW and dreaming and found many similarities: in both states, content is largely audiovisual and emotional, follows loose narratives tinged with fantasy, is strongly related to current concerns, draws on long-term memory, and simulates social interactions. Both states are also characterized by a relative lack of meta-awareness. To relate first-person reports to neural evidence, we compared meta-analytic data from numerous functional neuroimaging (PET, fMRI) studies of the default mode network (DMN, with high chances of MW) and rapid eye movement (REM) sleep (with high chances of dreaming). Our findings show large overlaps in activation patterns of cortical regions: similar to MW/DMN activity, dreaming and REM sleep activate regions implicated in self-referential thought and memory, including medial prefrontal cortex (PFC), medial temporal lobe structures, and posterior cingulate. Conversely, in REM sleep numerous PFC executive regions are deactivated, even beyond levels seen during waking MW. We argue that dreaming can be understood as an "intensified" version of waking MW: though the two share many similarities, dreams tend to be longer, more visual and immersive, and to more strongly recruit numerous key hubs of the DMN. Further, whereas MW recruits fewer PFC regions than goal-directed thought, dreaming appears to be characterized by an even deeper quiescence of PFC regions involved in cognitive control and metacognition, with a corresponding lack of insight and meta-awareness. We suggest, then, that dreaming amplifies the same features that distinguish MW from goal-directed waking thought.

  7. Effect of a 6-week dynamic neuromuscular training programme on ankle joint function: A Case report.

    Science.gov (United States)

    O'Driscoll, Jeremiah; Kerin, Fearghal; Delahunt, Eamonn

    2011-06-09

    Ankle joint sprain and the subsequent development of chronic ankle instability (CAI) are commonly encountered by clinicians involved in the treatment and rehabilitation of musculoskeletal injuries. It has recently been advocated that ankle joint post-sprain rehabilitation protocols should incorporate dynamic neuromuscular training to enhance ankle joint sensorimotor capabilities. To date no studies have reported on the effects of dynamic neuromuscular training on ankle joint positioning during landing from a jump, which has been reported as one of the primary injury mechanisms for ankle joint sprain. This case report details the effects of a 6-week dynamic neuromuscular training programme on ankle joint function in an athlete with CAI. The athlete took part in a progressive 6-week dynamic neuromuscular training programme which incorporated postural stability, strengthening, plyometric, and speed/agility drills. The outcome measures chosen to assess for interventional efficacy were: 1 Cumberland Ankle Instability Tool (CAIT) scores, 2 Star Excursion Balance Test (SEBT) reach distances, 3 ankle joint plantar flexion during drop landing and drop vertical jumping, and 4 ground reaction forces (GRFs) during walking. CAIT and SEBT scores improved following participation in the programme. The angle of ankle joint plantar flexion decreased at the point of initial contact during the drop landing and drop vertical jumping tasks, indicating that the ankle joint was in a less vulnerable position upon landing following participation in the programme. Furthermore, GRFs were reduced whilst walking post-intervention. The 6-week dynamic neuromuscular training programme improved parameters of ankle joint sensorimotor control in an athlete with CAI. Further research is now required in a larger cohort of subjects to determine the effects of neuromuscular training on ankle joint injury risk factors.

  8. Effect of a 6-week dynamic neuromuscular training programme on ankle joint function: A Case report

    LENUS (Irish Health Repository)

    O'Driscoll, Jeremiah

    2011-06-09

    Abstract Background Ankle joint sprain and the subsequent development of chronic ankle instability (CAI) are commonly encountered by clinicians involved in the treatment and rehabilitation of musculoskeletal injuries. It has recently been advocated that ankle joint post-sprain rehabilitation protocols should incorporate dynamic neuromuscular training to enhance ankle joint sensorimotor capabilities. To date no studies have reported on the effects of dynamic neuromuscular training on ankle joint positioning during landing from a jump, which has been reported as one of the primary injury mechanisms for ankle joint sprain. This case report details the effects of a 6-week dynamic neuromuscular training programme on ankle joint function in an athlete with CAI. Methods The athlete took part in a progressive 6-week dynamic neuromuscular training programme which incorporated postural stability, strengthening, plyometric, and speed\\/agility drills. The outcome measures chosen to assess for interventional efficacy were: 1 Cumberland Ankle Instability Tool (CAIT) scores, 2 Star Excursion Balance Test (SEBT) reach distances, 3 ankle joint plantar flexion during drop landing and drop vertical jumping, and 4 ground reaction forces (GRFs) during walking. Results CAIT and SEBT scores improved following participation in the programme. The angle of ankle joint plantar flexion decreased at the point of initial contact during the drop landing and drop vertical jumping tasks, indicating that the ankle joint was in a less vulnerable position upon landing following participation in the programme. Furthermore, GRFs were reduced whilst walking post-intervention. Conclusions The 6-week dynamic neuromuscular training programme improved parameters of ankle joint sensorimotor control in an athlete with CAI. Further research is now required in a larger cohort of subjects to determine the effects of neuromuscular training on ankle joint injury risk factors.

  9. Department of Energy Emergency Management Functional Requirements Study

    International Nuclear Information System (INIS)

    1987-05-01

    This Study, the Emergency Management Functional Requirements Study (EMFRS), identifies the physical environment, information resources, and equipment required in the DOE Headquarters Emergency Operations Center (EOC) to support the DOE staff in managing an emergency. It is the first step toward converting the present Forrestal EOC into a practical facility that will function well in each of the highly diverse types of emergencies in which the Department could be involved. 2 figs

  10. Variable reporting of functional outcomes and return to play in superior labrum anterior and posterior tear.

    Science.gov (United States)

    Steinhaus, Michael E; Makhni, Eric C; Lieber, Adam C; Kahlenberg, Cynthia A; Gulotta, Lawrence V; Romeo, Anthony A; Verma, Nikhil N

    2016-11-01

    Outcomes assessments after superior labrum anterior and posterior (SLAP) tear/repair are highly varied, making it difficult to draw comparisons across the literature. This study examined the inconsistency in outcomes reporting in the SLAP tear literature. We hypothesize that there is significant variability in outcomes reporting and that although most studies may report return to play, time to return reporting will be highly variable. The PubMed, Medline, Scopus, and Embase databases were systematically reviewed for studies from January 2000 to December 2014 reporting outcomes after SLAP tear/repair. Two reviewers assessed each study, and those meeting inclusion criteria were examined for pertinent data. Outcomes included objective (range of motion, strength, clinical examinations, and imaging) and subjective (patient-reported outcomes, satisfaction, activities of daily living, and return to play) measures. Of the 56 included studies, 43% documented range of motion, 14% reported strength, and 16% noted postoperative imaging. There was significant variation in use of patient-reported outcomes measures, with the 3 most commonly noted measures reported in 20% to 55% of studies. Return to play was noted in 75% of studies, and 23% reported time to return, with greater rates in elite athletes. Eleven studies (20%) did not report follow-up or noted data with <12 months of follow-up. The SLAP literature is characterized by substantial variability in outcomes reporting, with time to return to play noted in few studies. Efforts to standardize outcomes reporting would facilitate comparisons across the literature and improve our understanding of the prognosis of this injury. Copyright © 2016 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

  11. Relationship between functional connectivity and motor function assessment in stroke patients with hemiplegia: a resting-state functional MRI study

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Ye; Wang, Li; Zhang, Jingna; Sang, Linqiong; Li, Pengyue; Qiu, Mingguo [Third Military Medical University, Department of Medical Imaging, College of Biomedical Engineering, Chongqing (China); Liu, Hongliang; Yan, Rubing [Third Military Medical University, Department of Rehabilitation, Southwest Hospital, Chongqing (China); Yang, Jun; Wang, Jian [Third Military Medical University, Department of Radiology, Southwest Hospital, Chongqing (China)

    2016-05-15

    Resting-state functional magnetic resonance imaging (fMRI) has been used to examine the brain mechanisms of stroke patients with hemiplegia, but the relationship between functional connectivity (FC) and treatment-induced motor function recovery has not yet been fully investigated. This study aimed to identify the brain FC changes in stroke patients and study the relationship between FC and motor function assessment using the resting-state fMRI. Seventeen stroke patients with hemiplegia and fifteen healthy control subjects (HCSs) were recruited in this study. We compared the FC between the ipsilesional primary motor cortex (M1) and the whole brain of the patients with the FC of the HCSs and studied the FC changes in the patients before and after conventional rehabilitation and motor imagery therapy. Additionally, correlations between the FC change and motor function of the patients were studied. Compared to the HCSs, the FC in the patient group was significantly increased between the ipsilesional M1 and the ipsilesional inferior parietal cortex, frontal gyrus, supplementary motor area (SMA), and contralesional angular and decreased between the ipsilesional M1 and bilateral M1. After the treatment, the FC between the ipsilesional M1 and contralesional M1 increased while the FC between the ipsilesional M1 and ipsilesional SMA and paracentral lobule decreased. A statistically significant correlation was found between the FC change in the bilateral M1 and the Fugl-Meyer assessment (FMA) score change. Our results revealed an abnormal motor network after stroke and suggested that the FC could serve as a biomarker of motor function recovery in stroke patients with hemiplegia. (orig.)

  12. Relationship between functional connectivity and motor function assessment in stroke patients with hemiplegia: a resting-state functional MRI study

    International Nuclear Information System (INIS)

    Zhang, Ye; Wang, Li; Zhang, Jingna; Sang, Linqiong; Li, Pengyue; Qiu, Mingguo; Liu, Hongliang; Yan, Rubing; Yang, Jun; Wang, Jian

    2016-01-01

    Resting-state functional magnetic resonance imaging (fMRI) has been used to examine the brain mechanisms of stroke patients with hemiplegia, but the relationship between functional connectivity (FC) and treatment-induced motor function recovery has not yet been fully investigated. This study aimed to identify the brain FC changes in stroke patients and study the relationship between FC and motor function assessment using the resting-state fMRI. Seventeen stroke patients with hemiplegia and fifteen healthy control subjects (HCSs) were recruited in this study. We compared the FC between the ipsilesional primary motor cortex (M1) and the whole brain of the patients with the FC of the HCSs and studied the FC changes in the patients before and after conventional rehabilitation and motor imagery therapy. Additionally, correlations between the FC change and motor function of the patients were studied. Compared to the HCSs, the FC in the patient group was significantly increased between the ipsilesional M1 and the ipsilesional inferior parietal cortex, frontal gyrus, supplementary motor area (SMA), and contralesional angular and decreased between the ipsilesional M1 and bilateral M1. After the treatment, the FC between the ipsilesional M1 and contralesional M1 increased while the FC between the ipsilesional M1 and ipsilesional SMA and paracentral lobule decreased. A statistically significant correlation was found between the FC change in the bilateral M1 and the Fugl-Meyer assessment (FMA) score change. Our results revealed an abnormal motor network after stroke and suggested that the FC could serve as a biomarker of motor function recovery in stroke patients with hemiplegia. (orig.)

  13. Evaluation of recovery in hydronephrosis using renal functional CT studies

    International Nuclear Information System (INIS)

    Watanabe, Kiyotaka

    1985-01-01

    Using renal functional CT studies, we studied 22 patients who underwent surgical treatment for unilateral hydronephrosis. The tissue-plasma ratio of contrast enhancement (TPR), which is an indicator of renal function per unit of parenchymal volume, improved after the operation. On the other hand, the renal parenchymal volume (PV) decreased in proportion to the shrinkage of the kidney. The pre and postoperative values of renal functional index (RFI), the product of the TPR and PV, showed a good correlation (r=0.928, p<0.01). Therefore, RFI values were found to be useful for assessing the recovery of hydronephrosis. (author)

  14. Renal function and long-term decline in cognitive function: the Baltimore Longitudinal Study of Aging.

    Science.gov (United States)

    Seliger, Stephen L; Wendell, Carrington R; Waldstein, Shari R; Ferrucci, Luigi; Zonderman, Alan B

    2015-01-01

    Renal disease has been associated with greater risk of dementia and greater cognitive impairment. However, the relationship of lower renal function with long-term decline in specific domains of cognitive function remains unclear among community-dwelling, non-demented individuals. Stroke- and dementia-free participants (n = 2,116) were enrolled in the Baltimore Longitudinal Study of Aging, a community-based, prospective, longitudinal study. Renal function was estimated by the inverse of serum creatinine adjusted for age, sex and race and (in sensitivity analyses) estimated glomerular filtration rate (eGFR) using the MDRD formula. Outcome measures were changes in scores on 6 cognitive tests encompassing a range of cognitive functions, measured at 2-year intervals. Mixed-effects regression models examined the longitudinal relations of renal function with cognitive functions after adjusting for demographics, comorbidity and other potential confounders. Mean age at initial testing was 53.9 years (SD 17.1), and 94 participants (4.4%) had an eGFR age, longitudinal increases in creatinine concentrations were associated with more rapid decline in performance on several cognitive measures, including the learning slope of the California Verbal Learning Test, a test of verbal learning (p renal function independently associated with greater long-term declines in visual memory and verbal memory and learning. © 2015 National Institutes of Health (NIH). Published by S. Karger AG, Basel.

  15. The influence of unilateral saccular impairment on functional balance performance and self-report dizziness.

    Science.gov (United States)

    McCaslin, Devin L; Jacobson, Gary P; Grantham, Sarah L; Piker, Erin G; Verghese, Susha

    2011-09-01

    Postural stability in humans is largely maintained by vestibular, visual, and somatosensory inputs to the central nervous system. Recent clinical advances in the assessment of otolith function (e.g., cervical and ocular vestibular evoked myogenic potentials [cVEMPs and oVEMPs], subjective visual vertical [SVV] during eccentric rotation) have enabled investigators to identify patients with unilateral otolith impairments. This research has suggested that patients with unilateral otolith impairments perform worse than normal healthy controls on measures of postural stability. It is not yet known if patients with unilateral impairments of the saccule and/or inferior vestibular nerve (i.e., unilaterally abnormal cVEMP) perform differently on measures of postural stability than patients with unilateral impairments of the horizontal SCC (semicircular canal) and/or superior vestibular nerve (i.e., unilateral caloric weakness). Further, it is not known what relationship exists, if any, between otolith system impairment and self-report dizziness handicap. The purpose of this investigation was to determine the extent to which saccular impairments (defined by a unilaterally absent cVEMP) and impairments of the horizontal semicircular canal (as measured by the results of caloric testing) affect vestibulospinal function as measured through the Sensory Organization Test (SOT) of the computerized dynamic posturography (CDP). A secondary objective of this investigation was to measure the effects, if any, that saccular impairment has on a modality-specific measure of health-related quality of life. A retrospective cohort study. Subjects were assigned to one of four groups based on results from balance function testing: Group 1 (abnormal cVEMP response only), Group 2 (abnormal caloric response only), Group 3 (abnormal cVEMP and abnormal caloric response), and Group 4 (normal control group). Subjects were 92 adult patients: 62 were seen for balance function testing due to complaints

  16. Report of studies on geothermal steam

    Energy Technology Data Exchange (ETDEWEB)

    1954-09-01

    At the time of this report the exploitation of geothermal steam wells was only in the experimental stage. A great deal of information was derived for future use however. The steam is described in terms of its origin and characteristics and the life expectancy of the wells is estimated. Experimental work in Otake, Hakuryu, Beppu and Naruko is described. The power generation station at Larderello, Italy, is discussed. Extensive data from the experimental wells are summarized in tables.

  17. Studies of human mutation rates: Progress report

    International Nuclear Information System (INIS)

    Neel, J.V.

    1988-01-01

    Progress was recorded between January 1 and July 1, 1987 on a project entitled ''Studies of Human Mutation Rates''. Studies underway include methodology for studying mutation at the DNA level, algorithms for automated analyses of two-dimensional polyacrylamide DNA gels, theoretical and applied population genetics, and studies of mutation frequency in A-bomb survivors

  18. Do newspaper reports of suicides comply with standard suicide reporting guidelines? A study from Bangalore, India.

    Science.gov (United States)

    Chandra, Prabha S; Doraiswamy, Padmavathy; Padmanabh, Anuroopa; Philip, Mariamma

    2014-11-01

    Several countries have prescribed standard guidelines for media professionals on suicide reporting. However, the implementation of these guidelines has been varied. Suicide rates in South Asia are one of the highest in the world, and it is known that media guidelines for suicide reporting are not followed adequately. However, there are no published reports available from this region. This study aimed at assessing newspaper reports of suicide for quality of reporting based on standard reporting guidelines and to study differences between English and vernacular (Kannada) newspapers in Bangalore, South India. A total of 341 newspaper reports of suicide from 550 newspapers (3 English and 3 Kannada) over 3 months were systematically assessed for compliance with reporting guidelines. Each report was evaluated on 2 domains and 36 parameters. Data were analyzed for frequency of inappropriate reporting and patterns compared between vernacular and English newspapers. In all, 87% of the reports were those of completed suicide. Non-compliant reporting - method of suicide was reported in 89% and 32% of reports were in prominent pages of the newspaper, 95% mentioned gender, 90% reported the name, 80% reported age and suicide location, 75% reported life events related to suicide, 70% reported occupation, 69% had headline explicity on suicide and 61% reported monocausality. Only 16% reported mental disorder related to suicide, and less than 3% included information on suicide prevention and helplines. Vernacular papers showed significantly better compliance in 16 of the 20 areas. However, protective characteristics were better reported in English newspapers. Majority of reports on suicides in newspapers from Bangalore did not comply with standard guidelines of reporting. There is a strong need to evolve local guidelines and mechanisms for ensuring responsible reporting which have important implications in prevention of suicide. © The Author(s) 2013.

  19. Questionnaire-based assessment of executive functioning: Case studies.

    Science.gov (United States)

    Kronenberger, William G; Castellanos, Irina; Pisoni, David B

    2018-01-01

    Delays in the development of executive functioning skills are frequently observed in pediatric neuropsychology populations and can have a broad and significant impact on quality of life. As a result, assessment of executive functioning is often relevant for the development of formulations and recommendations in pediatric neuropsychology clinical work. Questionnaire-based measures of executive functioning behaviors in everyday life have unique advantages and complement traditional neuropsychological measures of executive functioning. Two case studies of children with spina bifida are presented to illustrate the clinical use of a new questionnaire measure of executive and learning-related functioning, the Learning, Executive, and Attention Functioning Scale (LEAF). The LEAF emphasizes clinical utility in assessment by incorporating four characteristics: brevity in administration, breadth of additional relevant content, efficiency of scoring and interpretation, and ease of availability for use. LEAF results were consistent with another executive functioning checklist in documenting everyday behavior problems related to working memory, planning, and organization while offering additional breadth of assessment of domains such as attention, processing speed, and novel problem-solving. These case study results demonstrate the clinical utility of questionnaire-based measurement of executive functioning in pediatric neuropsychology and provide a new measure for accomplishing this goal.

  20. ESPGHAN and NASPGHAN Report on the Assessment of Exocrine Pancreatic Function and Pancreatitis in Children

    NARCIS (Netherlands)

    Taylor, Christopher J.; Chen, Kathy; Horvath, Karoly; Hughes, David; Lowe, Mark E.; Mehta, Devendra; Orabi, Abrahim I.; Screws, Jeremy; Thomson, Mike; Van Biervliet, Stephanie; Verkade, Henkjan J.; Husain, Sohail Z.; Wilschanski, Michael

    The purpose of this clinical report is to discuss several recent advances in assessing exocrine pancreatic insufficiency (EPI) and pancreatitis in children, to review the array of pancreatic function tests, to provide an update on the inherited causes of EPI, with special emphasis on newly available

  1. Levels of Personality Functioning Scale Self-Report Validation Journal of Personality Assessment

    OpenAIRE

    Good, Evan; Hopwood, Christopher; Morey, Leslie

    2017-01-01

    Validation of the Levels of Personality Functioning Scale - Self-Report. Results suggest that the measure has a robust single dimension and that it correlates in a very general manner with a wide range of maladaptive personality variables, consistent with its purpose as a measure of non-specific personality pathology.

  2. Wind Turbine Generator System Safety and Function Test Report for the Entegrity EW50 Wind Turbine

    Energy Technology Data Exchange (ETDEWEB)

    Smith, J.; Huskey, A.; Jager, D.; Hur, J.

    2012-11-01

    This report summarizes the results of a safety and function test that NREL conducted on the Entegrity EW50 wind turbine. This test was conducted in accordance with the International Electrotechnical Commissions' (IEC) standard, Wind Turbine Generator System Part 2: Design requirements for small wind turbines, IEC 61400-2 Ed.2.0, 2006-03.

  3. An Evidence-Driven, Solution-Focused Approach to Functional Behavior Assessment Report Writing

    Science.gov (United States)

    Farmer, Ryan L.; Floyd, Randy G.

    2016-01-01

    School-based practitioners are to implement and report functional behavior assessments (FBAs) that are consistent with both the research literature and the law, both federal and state. However, the literature regarding how best to document the FBA process is underdeveloped. A review of applied behavior analytic and school psychology literature as…

  4. Improving patients' understanding of terms and phrases commonly used in self-reported measures of sexual function.

    Science.gov (United States)

    Alexander, Angel M; Flynn, Kathryn E; Hahn, Elizabeth A; Jeffery, Diana D; Keefe, Francis J; Reeve, Bryce B; Schultz, Wesley; Reese, Jennifer Barsky; Shelby, Rebecca A; Weinfurt, Kevin P

    2014-08-01

    There is a significant gap in research regarding the readability and comprehension of existing sexual function measures. Patient-reported outcome measures may use terms not well understood by respondents with low literacy. This study aims to test comprehension of words and phrases typically used in sexual function measures to improve validity for all individuals, including those with low literacy. We recruited 20 men and 28 women for cognitive interviews on version 2.0 of the Patient-Reported Outcome Measurement Information System(®) (PROMIS(®) ) Sexual Function and Satisfaction measures. We assessed participants' reading level using the word reading subtest of the Wide Range Achievement Test. Sixteen participants were classified as having low literacy. In the first round of cognitive interviews, each survey item was reviewed by five or more people, at least two of whom had lower than a ninth-grade reading level (low literacy). Patient feedback was incorporated into a revised version of the items. In the second round of interviews, an additional three or more people (at least one with low literacy) reviewed each revised item. Participants with low literacy had difficulty comprehending terms such as aroused, orgasm, erection, ejaculation, incontinence, and vaginal penetration. Women across a range of literacy levels had difficulty with clinical terms like labia and clitoris. We modified unclear terms to include parenthetical descriptors or slang equivalents, which generally improved comprehension. Common words and phrases used across measures of self-reported sexual function are not universally understood. Researchers should appreciate these misunderstandings as a potential source of error in studies using self-reported measures of sexual function. This study also provides evidence for the importance of including individuals with low literacy in cognitive pretesting during the measure development. © 2014 International Society for Sexual Medicine.

  5. Pain perception and hypnosis: findings from recent functional neuroimaging studies.

    Science.gov (United States)

    Del Casale, Antonio; Ferracuti, Stefano; Rapinesi, Chiara; Serata, Daniele; Caltagirone, Saverio Simone; Savoja, Valeria; Piacentino, Daria; Callovini, Gemma; Manfredi, Giovanni; Sani, Gabriele; Kotzalidis, Georgios D; Girardi, Paolo

    2015-01-01

    Hypnosis modulates pain perception and tolerance by affecting cortical and subcortical activity in brain regions involved in these processes. By reviewing functional neuroimaging studies focusing on pain perception under hypnosis, the authors aimed to identify brain activation-deactivation patterns occurring in hypnosis-modulated pain conditions. Different changes in brain functionality occurred throughout all components of the pain network and other brain areas. The anterior cingulate cortex appears to be central in modulating pain circuitry activity under hypnosis. Most studies also showed that the neural functions of the prefrontal, insular, and somatosensory cortices are consistently modified during hypnosis-modulated pain conditions. Functional neuroimaging studies support the clinical use of hypnosis in the management of pain conditions.

  6. Computational study on the functionalization of BNNC with pyrrole molecule

    Science.gov (United States)

    Payvand, Akram; Tavangar, Zahra

    2018-05-01

    The functionalization of the boron nitride nanocone (BNNC) by pyrrole molecule was studied using B3LYP/6-311+G(d) level of theory. The reaction was studied in three methods in different layers of the nanocone: Diels-Alder cycloaddition, quartet cycloaddition and the reaction of the nitrogen atom of the pyrrole molecule with the boron or nitrogen atom of the BNNC. Thermodynamic quantities, Chemical hardness and potential and electrophilicity index of the functionalized BNNC were studied. The results show that the tip of nanocone has a higher tendency for participation in the reaction and the most favorable product of the reaction between BNNC and pyrrole molecule is produced from the reaction of N atom of pyrrole with the B atom of BNNC. The reaction decreases the energy gap value which leads to increasing the reactivity and conductivity of functionalized nanocone. The calculated NICS values confirm the aromaticity in the pristine nanocone as well as in the functionalized nanocone.

  7. Neuropsychological function in a child with 18p deletion syndrome: a case report.

    Science.gov (United States)

    Willoughby, Brian L; Favero, Marcus; Mochida, Ganeshwaran H; Braaten, Ellen B

    2014-09-01

    We report the neuropsychological profile of a 4-year-old boy with the rare 18p deletion syndrome. We used a battery of standardized tests to assess his development in intellect, language, visuomotor integration, academic readiness, socialization, and emotional and behavioral health. The results showed borderline intellectual function except for low average nonverbal reasoning skills. He had stronger receptive than expressive language skills, although both were well below his age group. He had impaired visuomotor integration and pre-academic skills such as letter identification. Emotional and behavioral findings indicated mild aggressiveness, anxiety, low frustration tolerance, and executive function weaknesses, especially at home. Interestingly, he showed social strengths, responding to joint attention and sharing enjoyment with his examiner. With its assessment of development in many domains, this case report is among the first to characterize the neuropsychological and psychiatric function of a young child with 18p deletion syndrome. We discuss the implications of our findings for clinical practice.

  8. Contribution of enterprise risk management and internal audit function towards quality of financial reporting in universities in a developing country

    Directory of Open Access Journals (Sweden)

    Newman Wadesango

    2017-05-01

    Full Text Available Quality of financial reporting is limited to issues of compliance to statutory provisions under which state enterprises in Zimbabwe operate, usefulness of the reports produced and their impact on the national fiscus. It is thus measured by way of compliance to these expectations and is indicated by way of a disclosure index signifying the presence of each of the expected aspects. This study therefore sought to establish the contribution of enterprise risk management and internal audit function towards the quality of financial reporting in universities in Zimbabwe. The study adopted a desktop analysis where relevant literature was reviewed. Quality of internal audit function was found to influence quality of financial reporting in that the strength, or quality, of the IAF will contribute to a distinctly different control environment depending on the strength of the good corporate governance in the university. Findings of this desktop research have undoubtedly revealed the gaps in the governance processes in state universities and it is envisaged that a careful analysis of these lacunas will provide a guide in the development of strategies and policy that strengthen state enterprise governance processes. It is hoped that this will help the parent ministry in charge of state enterprises, and, the relevant management of specific state enterprises to determine the magnitude of resources and efforts for implementation of efficient and effective enterprise risk management, internal audit function and corporate governance systems

  9. Biodiesel in British Columbia : feasibility study report

    Energy Technology Data Exchange (ETDEWEB)

    Boyd, M.; Murray-Hill, A.; Schaddelee, K. [Wise Energy Co-op, Victoria, BC (Canada)

    2004-05-05

    This report evaluates the potential for biodiesel as a viable fuel in British Columbia. Biodiesel is a non-toxic, biodegradable, renewable fuel produced from recycled bio-oils that can be used to replace conventional petroleum diesel. The report also examines potential feedstock characteristics, output volumes and environmental impacts. Production of biodiesel is increasing globally due to its economic, human and environmental health benefits. Canada's Climate Change Action Plan target of 500 million litres of biodiesel production per year by 2010 will also contribute to biodiesel growth. The use of pure biodiesel as an alternative fuel results in reduced emissions of carbon dioxide, sulphur dioxide, methane, unburned hydrocarbons, carbon monoxide, particulate matter and polycyclic aromatic hydrocarbons. British Columbia's biodiesel feedstock volumes yield a total theoretical capacity of 125 million litres per year of biodiesel, or 4.5 per cent of the province's total annual diesel consumption The feedstock is enough to fuel over 3,700 transit buses annually and significantly reduce greenhouse gas emissions. This report outlines the activities needed to establish commercial biodiesel companies in the province. It also examines standards and regulatory issues; technology availability; cost and processing analysis; potential markets and distribution channels; and environmental impact comparisons. The 4 critical factors that will determine the success or failure of a commercial biodiesel project include: the ability to balance feedstock supplies, processing technology, and market penetration in an integrated system that is reliable and efficient; the ability to form stable strategic alliances with feedstock suppliers, distributors and end users; the ability to deal effectively with competitive pressures; and, the ability to generate a business plan that will attract financing. It was concluded that community-based biodiesel production at a plant scale

  10. Medical waste irradiation study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Adler, R.J.; Stein, J. [North Star Research Corp., Albuquerque, NM (United States); Nygard, J. [Advance Bio-Control (United States)

    1998-07-25

    The North Star Research Corporation Medical Waste project is described in this report, with details of design, construction, operation, and results to date. The project began with preliminary design of the accelerator. The initial design was for a single accelerator chamber with a vacuum tube cavity driver built into the chamber itself, rather than using a commercial tube separate from the RF accelerator. The authors believed that this would provide more adjustability and permit better coupling to be obtained. They did not have sufficient success with that approach, and finally completed the project using a DC accelerator with a unique new scanning system to irradiate the waste.

  11. Medical waste irradiation study. Final report

    International Nuclear Information System (INIS)

    Adler, R.J.; Stein, J.; Nygard, J.

    1998-01-01

    The North Star Research Corporation Medical Waste project is described in this report, with details of design, construction, operation, and results to date. The project began with preliminary design of the accelerator. The initial design was for a single accelerator chamber with a vacuum tube cavity driver built into the chamber itself, rather than using a commercial tube separate from the RF accelerator. The authors believed that this would provide more adjustability and permit better coupling to be obtained. They did not have sufficient success with that approach, and finally completed the project using a DC accelerator with a unique new scanning system to irradiate the waste

  12. Study of the effects of uranium on kidney function

    International Nuclear Information System (INIS)

    Moss, M.A.

    1989-03-01

    The chemical toxicity of inhaled or ingested soluble uranium, especially its nephrotoxicity surpasses its radiotoxicity. Because of the functional overcapacity of the kidney, it is probable that adverse effects on renal function due to occupational uranium exposure may be sustained long before this becomes evident. The advent of more sensitive and specific tests, particularly of proximal tubular dysfunction, suggests that it may now be possible to detect and monitor such sub-clinical effects on renal function. The Atomic Energy Control Board requires an updated review of uranium nephrotoxicity, and an evaluation of the various tests available which might be used to detect altered kidney function in uranium workers. Recommendations are also required regarding occupational studies which could be conducted in these workers to assess their current state of kidney function and possibly serve as monitoring tools in the future

  13. Executive functions in becoming writing readers and reading writers: note taking and report writing in third and fifth graders.

    Science.gov (United States)

    Altemeier, Leah; Jones, Janine; Abbott, Robert D; Berninger, Virginia W

    2006-01-01

    Results are reported for a study of 2 separate processes of report writing-taking notes while reading source material and composing a report from those notes-and related individual differences in executive functions involved in integrating reading and writing during these writing activities. Third graders (n = 122) and 5th graders (n = 106; overall, 127 girls and 114 boys) completed two reading-writing tasks-read paragraph (mock science text)-write notes and use notes to generate written report, a reading comprehension test, a written expression test, four tests of executive functions (inhibition, verbal fluency, planning, switching attention), and a working memory test. For the read-take notes task, the same combination of variables was best (explained the most variance and each variable added unique variance) for 3rd graders and 5th graders: Wechsler Individual Achievement Test-Second Edition (WIAT-II) Reading Comprehension, Process Assessment of the Learner Test for Reading and Writing (PAL) Copy Task B, WIAT-II Written Expression, and Delis-Kaplan Executive Function System (D-KEFS) Inhibition. For the use notes to write report task, the best combinations of variables depended on grade level: For 3rd graders, WIAT-II Reading Comprehension, WIAT-II Written Expression, D-KEFS Verbal Fluency, and Tower of Hanoi; for 5th graders, WIAT-II Reading Comprehension, D-KEFS Verbal Fluency, WIAT-II Written Expression, and PAL Alphabet Task. These results add to prior research findings that executive functions contribute to the writing development of elementary-grade students and additionally support the hypothesis that executive functions play a role in developing reading-writing connections.

  14. Work functioning trajectories in cancer patients: Results from the longitudinal Work Life after Cancer (WOLICA) study.

    Science.gov (United States)

    Dorland, Heleen F; Abma, Femke I; Roelen, Corné A M; Stewart, Roy E; Amick, Benjamin C; Ranchor, Adelita V; Bültmann, Ute

    2017-11-01

    More than 60% of cancer patients are able to work after cancer diagnosis. However, little is known about their functioning at work. Therefore, the aims of this study were to (1) identify work functioning trajectories in the year following return to work (RTW) in cancer patients and (2) examine baseline sociodemographic, health-related and work-related variables associated with work functioning trajectories. This longitudinal cohort study included 384 cancer patients who have returned to work after cancer diagnosis. Work functioning was measured at baseline, 3, 6, 9 and 12 months follow-up. Latent class growth modeling (LCGM) was used to identify work functioning trajectories. Associations of baseline variables with work functioning trajectories were examined using univariate and multivariate analyses. LCGM analyses with cancer patients who completed on at least three time points the Work Role Functioning Questionnaire (n = 324) identified three work functioning trajectories: "persistently high" (16% of the sample), "moderate to high" (54%) and "persistently low" work functioning (32%). Cancer patients with persistently high work functioning had less time between diagnosis and RTW and had less often a changed meaning of work, while cancer patients with persistently low work functioning reported more baseline cognitive symptoms compared to cancer patients in the other trajectories. This knowledge has implications for cancer care and guidance of cancer patients at work. © 2017 UICC.

  15. Drivers of corporate social responsibility reporting; Case studies from three reporting companies

    Directory of Open Access Journals (Sweden)

    Daniel Tschopp PhD, MBA, CPA

    2013-07-01

    Past research cited several reasons companies issued reports, but it does not tell the whole story. These three individual case studies demonstrate the importance of the primary determinant behind an organization’s decision to issue a CSR report. This finding can provide valuable information for further studies that deal with the promotion, diffusion, and harmonization of CSR reporting.

  16. The association of menopause status with physical function: the Study of Women's Health Across the Nation.

    Science.gov (United States)

    Tseng, Lisa A; El Khoudary, Samar R; Young, Elizabeth A; Farhat, Ghada N; Sowers, MaryFran; Sutton-Tyrrell, Kim; Newman, Anne B

    2012-11-01

    The aim of this study was to determine whether postmenopause status is associated with self-reported limitations in physical function. The Study of Women's Health Across the Nation is a multisite, multiethnic, longitudinal study of midlife women. Women aged 45 to 57 years (N = 2,566) completed the physical function scale of the Medical Outcomes Study Short-Form 36 on visit 4 (2000-2001). Scores created a three-category variable of physical function limitations: none (86-100), moderate (51-85), and substantial (0-50). In the Study of Women's Health Across the Nation, menopause status is a five-category list variable based on menstrual bleeding patterns and gynecological surgery. Premenopausal and perimenopausal women using hormones (n = 284) or missing physical function scores (n = 46) were excluded. Multinomial logistic regression was used to relate physical function and menopause status after adjustment for age, ethnicity, site, education, body mass index (BMI), and self-reported diabetes, hypertension, arthritis, depressive symptoms, smoking, and hormone use among postmenopausal women. Of 2,236 women, 8% were premenopausal, 51% were early perimenopausal, 12% were late perimenopausal, 24% were naturally postmenopausal, and 5% were surgically postmenopausal. In the full model, substantial limitations in physical function were higher in postmenopausal women, whether naturally postmenopausal (odds ratio, 3.82; 95% CI, 1.46-10.0) or surgically postmenopausal (odds ratio, 3.54; 95% CI, 1.15-10.84), than in premenopausal women. These associations were attenuated by higher BMI and depressive symptoms but remained significant. Moderate limitations in physical function were not significantly related to menopause status. Women experiencing surgical or naturally occurring postmenopause report greater limitations in physical function compared with premenopausal women, independent of age and only partly explained by higher BMI and depressive symptoms. This suggests that

  17. Third International Mathematics and Science Study 1999 Video Study Technical Report: Volume 2--Science. Technical Report. NCES 2011-049

    Science.gov (United States)

    Garnier, Helen E.; Lemmens, Meike; Druker, Stephen L.; Roth, Kathleen J.

    2011-01-01

    This second volume of the Third International Mathematics and Science Study (TIMSS) 1999 Video Study Technical Report focuses on every aspect of the planning, implementation, processing, analysis, and reporting of the science components of the TIMSS 1999 Video Study. The report is intended to serve as a record of the actions and documentation of…

  18. Pulmonary functions in plastic factory workers: a preliminary study.

    Science.gov (United States)

    Khaliq, Farah; Singh, Pawan; Chandra, Prakash; Gupta, Keshav; Vaney, Neelam

    2011-01-01

    Exposure to long term air pollution in the work environment may result in decreased lung functions and various other health problems. A significant occupational hazard to lung functions is experienced by plastic factory workers. The present study is planned to assess the pulmonary functions of workers in the plastic factory where recycling of pastic material was done. These workers were constantly exposed to fumes of various chemicals throughout the day. Thirty one workers of plastic factory were assessed for their pulmonary functions. Parameters were compared with 31 age and sex matched controls not exposed to the same environment. The pulmonary function tests were done using Sibelmed Datospir 120 B portable spirometer. A significant decrease in most of the flow rates (MEF 25%, MEF 50%, MEF 75% and FEF 25-75%) and most of the lung volumes and capacities (FVC, FEV1, VC, TV, ERV, MVV) were observed in the workers. Smoking and duration of exposure were not affecting the lung functions as the non smokers also showed a similar decrement in pulmonary functions. Similarly the workers working for less than 5 years also had decrement in pulmonary functions indicating that their lungs are being affected even if they have worked for one year. Exposure to the organic dust in the work environment should be controlled by adequate engineering measures, complemented by effective personal respiratory protection.

  19. Emotion regulation and Residual Depression Predict Psychosocial Functioning in Bipolar Disorder: Preliminary Study

    OpenAIRE

    Becerra, Rodrigo; Cruise, Kate; Harms, Craig; Allan, Alfred; Bassett, Darryl; Hood, Sean; Murray, Greg

    2015-01-01

    This study explores the predictive value of various clinical, neuropsychological, functional, and emotion regulation processes for recovery in Bipolar Disorder. Clinical and demographic information was collected for 27 euthymic or residually depressed BD participants. Seventy one percent of the sample reported some degree of impairment in psychosocial functioning. Both residual depression and problems with emotion regulation were identified as significant predictors of poor psychosocial funct...

  20. Brain activation studies with PET and functional MRI

    Energy Technology Data Exchange (ETDEWEB)

    Yonekura, Yoshiharu [Fukui Medical Univ., Matsuoka (Japan). Biomedical Imaging Research Center; Sadato, Norihiro [Okazaki National Research Inst., Aichi (Japan). National Inst. for Physiological Sciences

    2002-01-01

    Application of PET and functional MRI in brain activation studies is reviewed. 3D-PET images obtained repeatedly after intravenous injection of about 370 MBq of H{sub 2}{sup 15}O can detect a faint blood flow change in the brain. Functional MRI can also detect the blood flow change in the brain due to blood oxygen level-dependent effect. Echo-planar imaging is popular in MRI with 1.5 or 3 T. Images are analyzed by statistical parametric mapping with correction of cerebral regions, anatomical normalization and statistics. PET data give the blood flow change by the H{sub 2}{sup 15}O incorporation into the brain and MRI data, by the scarce tissue oxygen consumption despite the change. Actual images during the cognition task-performance and of frequent artifacts are given. PET is suitable for studies of brain functions like sensibility and emotion and functional MRI, like cortex functions and clinical practices in identification of functional regions prior to surgery and evaluation of functional recovery of damaged brain. (K.H.)

  1. Brain activation studies with PET and functional MRI

    International Nuclear Information System (INIS)

    Yonekura, Yoshiharu; Sadato, Norihiro

    2002-01-01

    Application of PET and functional MRI in brain activation studies is reviewed. 3D-PET images obtained repeatedly after intravenous injection of about 370 MBq of H 2 15 O can detect a faint blood flow change in the brain. Functional MRI can also detect the blood flow change in the brain due to blood oxygen level-dependent effect. Echo-planar imaging is popular in MRI with 1.5 or 3 T. Images are analyzed by statistical parametric mapping with correction of cerebral regions, anatomical normalization and statistics. PET data give the blood flow change by the H 2 15 O incorporation into the brain and MRI data, by the scarce tissue oxygen consumption despite the change. Actual images during the cognition task-performance and of frequent artifacts are given. PET is suitable for studies of brain functions like sensibility and emotion and functional MRI, like cortex functions and clinical practices in identification of functional regions prior to surgery and evaluation of functional recovery of damaged brain. (K.H.)

  2. Waste Quantity, Mix and Throughput Study Report

    International Nuclear Information System (INIS)

    Ovadia E, Lev

    1997-01-01

    This report describes the impact that waste stream parameters have on repository design, including surface, subsurface and waste package designs. Two design basis waste streams and corresponding design levels are established for two documented inventories of wastes: (a) Mined Geologic Design System (MGDS) Baseline (Viability Assessment) (VA) and (b) Extended Baseline. The MGDS Baseline VA inventory is currently used as the basis for the VA design of the repository, and is limited by statutes to a total of 70,000 MTU. The Extended Baseline includes the total documented inventories of commercial spent nuclear fuel, high-level waste and US Department of Energy spent nuclear fuel. Impacts of the two design bases on surface, subsurface and waste package designs are projected. The impact of potential disposal of additional commercial and Department of Energy miscellaneous wastes on design is assessed qualitatively

  3. Early development of executive functions: a differential study

    Directory of Open Access Journals (Sweden)

    Sylvia Sastre-Riba

    2015-05-01

    Full Text Available The ontogeny of executive functions is essential in explaining differential and normative developmental trends. Executive functions must be studied from an early age given their consequential effects on mental flexibility, monitoring information, planning, and cognitive control. We propose a differential study in alternative developmental courses through observing typical babies, Down syndrome babies, and babies with risk-factors at birth (due to low weight or to congenital hypothyroidism. Applymg Systematic Observational Methodology, spontaneous babies' activity was registered. The results indicated that: a Typical babies showed better shifting and action flexibility in order to obtain a goal, thus better results; b Among the higher risk-babies, the lower efficacy in executive functioning was observed in underweight babies. Those with hypothyroidism were more in line with the typical babies; c Underweight babies showed a good level of combining actions but they obtained inferior results; d Down syndrome babies displayed more executive functioning difficulty, lower flexibility, high perseveration and less error detection.

  4. Renal functional CT studies of patients with nephrolithotomy

    International Nuclear Information System (INIS)

    Yokoyama, Masayoshi; Fujita, Kiyoshi; Watanabe, Kiyotaka; Ochi, Kenji; Takeuchi, Masafumi

    1985-01-01

    Renal functions of 13 patients, who underwent nephrolithotomy, were examined by the functional CT study. The warm ischemic time was 41+/-10 (mean+/-SD). After the operation, the tissueplasma ratio of contrast enhancement values failed to improve satisfactorily compared to that of the nonischemic hydronephrosis patients. Parenchymal volume decreased as much as that in the non-ischemic patients. As a result, Renal Functional Index (RFI) decreased significantly after nephrolithotomy. As RFI does not usually change in non-ischemic hydronephrosis after release of obstruction, the postischemic decrease of RFI may be caused mainly by ischemic damage and the effects of parechymal incision may not be dominant. (author)

  5. Photoelectric work function studies of carbonaceous films containing Ni nanocrystals

    International Nuclear Information System (INIS)

    Czerwosz, E.; Dluzewski, P.; Kutner, T.; Stacewicz, T.

    2003-01-01

    In this paper we present the results of photoelectric work function measurements for carbonaceous films containing Ni nanocrystals. The investigated films were obtained by thermal vacuum deposition method. The structure of films was studied by electron diffraction, transmission microscopy and Raman spectroscopy. Film structure depends on Ni contents in the film volume. Work function determined from photoelectric measurements for all investigated films are similar and lie in the range of 2.65-2.93 eV. The decrease of work function value with the cleaning of the film's surface with UV pulsed laser beam was observed

  6. Structural pathology is not related to patient-reported pain and function in patients undergoing meniscal surgery

    DEFF Research Database (Denmark)

    Christensen, Simon Tornbjerg; Nissen, Nis; Englund, Martin

    2017-01-01

    BACKGROUND: The relationship between meniscal tears and other joint pathologies with patient-reported symptoms is not clear. We investigated associations between structural knee pathologies identified at surgery with preoperative knee pain and function in patients undergoing arthroscopic meniscal...... of meniscal tears questionnaire, supplemented with information extracted from surgery reports. Following hypothesis-driven preselection of candidate variables, backward elimination regressions were performed to investigate associations between patient-reported outcomes and structural knee pathologies. RESULTS...... surgery. METHODS: This study included 443 patients from the Knee Arthroscopy Cohort Southern Denmark (KACS), a prospective cohort following patients 18 years or older undergoing arthroscopic meniscal surgery at 4 hospitals between 1 February 2013 and 31 January 2014. Patient-reported outcomes, including...

  7. Studies in genetic discrimination. Final progress report

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    We have screened 1006 respondents in a study of genetic discrimination. Analysis of these responses has produced evidence of the range of institutions engaged in genetic discrimination and demonstrates the impact of this discrimination on the respondents to the study. We have found that both ignorance and policy underlie genetic discrimination and that anti-discrimination laws are being violated.

  8. Theoretical studies of controlled fusion. Final report

    International Nuclear Information System (INIS)

    Krall, N.A.

    1986-01-01

    Transport in FRC was studied analytically and numerically. The physics considered included lower-hybrid-drift turbulence, rapid convection along closed magnetic field lines, nonadiabaticity, and large particle orbits. The study also extended conventional modeling procedures by developing nonlocal models of stability and transport and determined the relation between such models and the more widely used local models

  9. Functional priorities reported by parents of children with cerebral palsy: contribution to the pediatric rehabilitation process

    Directory of Open Access Journals (Sweden)

    Marina B. Brandão

    2014-12-01

    Full Text Available Background: Collaborative actions between family and therapist are essential to the rehabilitation process, and they can be a catalyst mechanism to the positive outcomes in children with cerebral palsy (CP. Objectives: To describe functional priorities established by caregivers of CP children by level of severity and age, and to assess changes on performance and satisfaction on functional priorities reported by caregivers, in 6-month interval. Method: 75 CP children, weekly assisted at Associação Mineira de Reabilitação, on physical and occupational therapy services. The following information was collected: gross motor function (Gross Motor Function Classification System-GMFCS and functional priorities established by caregivers (Canadian Occupational Performance Measure-COPM. Data were collected in two moments, with a 6-month interval. Results: The main functional demands presented by caregivers were related to self-care activities (48.2%. Parents of children with severe motor impairment (GMFCS V pointed higher number of demands related to play (p=0.0036, compared to the other severity levels. Parents of younger children reported higher number of demands in mobility (p=0.025 and play (p=0.007, compared to other age groups. After 6 months, there were significant increase on COPM performance (p=0.0001 and satisfaction scores (p=0.0001. Conclusions: Parents of CP children identified functional priorities in similar performance domains, by level of severity and age. Orienting the pediatric rehabilitation process to promote changes in functional priorities indentified by caregivers can contribute to the reinforcement of the parent-therapist collaboration.

  10. Membrane Protein Production in Lactococcus lactis for Functional Studies.

    Science.gov (United States)

    Seigneurin-Berny, Daphne; King, Martin S; Sautron, Emiline; Moyet, Lucas; Catty, Patrice; André, François; Rolland, Norbert; Kunji, Edmund R S; Frelet-Barrand, Annie

    2016-01-01

    Due to their unique properties, expression and study of membrane proteins in heterologous systems remains difficult. Among the bacterial systems available, the Gram-positive lactic bacterium, Lactococcus lactis, traditionally used in food fermentations, is nowadays widely used for large-scale production and functional characterization of bacterial and eukaryotic membrane proteins. The aim of this chapter is to describe the different possibilities for the functional characterization of peripheral or intrinsic membrane proteins expressed in Lactococcus lactis.

  11. Functional neuroimaging studies of episodic memory. Functional dissociation in the medial temporal lobe structures

    International Nuclear Information System (INIS)

    Tsukiura, Takashi

    2008-01-01

    Previous functional neuroimaging studies have demonstrated the critical role of the medial temporal lobe (MTL) regions in the encoding and retrieval of episodic memory. It has also been shown that an emotional factor in human memory enhances episodic encoding and retrieval. However, there is little evidence regarding the specific contribution of each MTL region to the relational, contextual, and emotional processes of episodic memory. The goal of this review article is to identify differential activation patterns of the processes between MTL regions. Results from functional neuroimaging studies of episodic memory show that the hippocampus is involved in encoding the relation between memory items, whereas the entorhinal and perirhinal cortices (anterior parahippocampal gyrus) contribute to the encoding of a single item. Additionally, the parahippocampal cortex (posterior parahippocampal gyrus) is selectively activated during the processing of contextual information of episodic memory. A similar pattern of functional dissociation is found in episodic memory retrieval. Functional neuroimaging has also shown that emotional information of episodic memory enhances amygdala-MTL correlations and that this enhancement is observed during both the encoding and retrieval of emotional memories. These findings from pervious neuroimaging studies suggest that different MTL regions could organize memory for personally experienced episodes via the 'relation' and 'context' factors of episodic memory, and that the emotional factor of episodes could modulate the functional organization in the MTL regions. (author)

  12. Chemical functionalization of graphene by carbene cycloaddition: A density functional theory study

    International Nuclear Information System (INIS)

    Zan, Wenyan

    2014-01-01

    Graphical abstract: - Highlights: • The reaction process of graphene functionalization with CCl 2 group in atomic scales was studied. • The potential candidate carbenes CR 2 (R = H, F, CN, NO 2 0 , NO 2 90 , CH 3 , OCH 3 , CCH, C 6 H 5 ) were separately combined with graphene. • The functionalization of graphene nanoribbon with dichlorocarbene group was investigated. • The electronic properties of graphene functionalized by carbene groups were discussed. - Abstract: In this work, we have systematically studied the structural, energetic and electronic properties of graphene functionalized with carbene groups by using density functional theory. Introducing a low concentration of CCl 2 group in graphene was studied in detail by DFT, and closed cyclopropane-like three-membered ring structure was formed, meanwhile, the potential candidate carbene groups CR 2 (R = H, F, CH 3 , CN, NO 2 , OCH 3 , CCH, C 6 H 5 ) were added to graphene sheet, and CR 2 (R = H, NO 2 , CH 3 ) groups were expected to be good reactive species to covalently modify graphene. The graphene functionalization with carbene groups above can open graphene's band gap. More CCl 2 molecules were added to graphene, and different concentrations of CCl 2 group can tune graphene's band gap. In addition, the addition of CCl 2 group to graphene edges was investigated, and the stronger binding energy was found. Multiple CCl 2 molecules preferred to be bound with the same edge of graphene nanoribbon. This work provides an insight into the detailed molecular mechanism of graphene functionalization with carbene groups

  13. Noninvasive imaging of transplanted living functional cells transfected with a reporter estrogen receptor gene

    Energy Technology Data Exchange (ETDEWEB)

    Takamatsu, Shinji [Biomedical Imaging Research Center, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Yoshida, Fukui 910-1193 (Japan)]. E-mail: shinjit@fmsrsa.fukui-med.ac.jp; Furukawa, Takako [Biomedical Imaging Research Center, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Yoshida, Fukui 910-1193 (Japan); Mori, Tetsuya [Biomedical Imaging Research Center, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Yoshida, Fukui 910-1193 (Japan); Yonekura, Yoshiharu [Biomedical Imaging Research Center, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Yoshida, Fukui 910-1193 (Japan); Fujibayashi, Yasuhisa [Biomedical Imaging Research Center, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Yoshida, Fukui 910-1193 (Japan)

    2005-11-01

    The transplantation of functional cells such as dopaminergic cells into damaged tissue is now clinically ongoing, but at present the population of surviving cells at the transplantation site mostly cannot be noninvasively examined. To visualize surviving transplanted functional cells using a noninvasive method, we chose the estrogen receptor ligand binding domain (ERL) as a reporter molecule and 16{alpha}-[{sup 18}F]-fluoro-17{beta}-estradiol (FES) for its ligand. We used a mouse embryonic stem (ES) cell line for recipient cells as a model. To obtain ES cells that constitutively or inducibly express ERL, we transfected two types of expression vectors into EB5 parental ES cell line using the lipofection method and obtained about 30 clones for each of the two types of transfectants. Then, to examine the expression level of ERL, we performed Western blotting analysis. Ligand uptake experiments were carried out using [{sup 3}H]-estradiol with or without excessive unlabeled estradiol for control cells and ERL transfectants. Each selected clone was also used for in vivo positron emission tomography (PET) imaging studies involving FES in nude mice transplanted with control cells and ERL transfectants. In some of the clones transfected with the inducible-type ERL gene, protein was expressed much higher than in the controls. However, constitutive-type ERL gene-transfected ES cells showed no protein production in spite of their gene expression activity being considerably high. All clones also expressed equal levels of the Oct-3/4 gene, a marker of pluripotency, in comparison with the parental cells. Also, the specific uptake of [{sup 3}H]-estradiol was over 30 times higher in inducer-treated ERL-expressing ES cells compared to untreated control cells. Finally, by performing dynamic PET imaging, we successfully visualized ERL-expressing teratomas using FES.

  14. Noninvasive imaging of transplanted living functional cells transfected with a reporter estrogen receptor gene

    International Nuclear Information System (INIS)

    Takamatsu, Shinji; Furukawa, Takako; Mori, Tetsuya; Yonekura, Yoshiharu; Fujibayashi, Yasuhisa

    2005-01-01

    The transplantation of functional cells such as dopaminergic cells into damaged tissue is now clinically ongoing, but at present the population of surviving cells at the transplantation site mostly cannot be noninvasively examined. To visualize surviving transplanted functional cells using a noninvasive method, we chose the estrogen receptor ligand binding domain (ERL) as a reporter molecule and 16α-[ 18 F]-fluoro-17β-estradiol (FES) for its ligand. We used a mouse embryonic stem (ES) cell line for recipient cells as a model. To obtain ES cells that constitutively or inducibly express ERL, we transfected two types of expression vectors into EB5 parental ES cell line using the lipofection method and obtained about 30 clones for each of the two types of transfectants. Then, to examine the expression level of ERL, we performed Western blotting analysis. Ligand uptake experiments were carried out using [ 3 H]-estradiol with or without excessive unlabeled estradiol for control cells and ERL transfectants. Each selected clone was also used for in vivo positron emission tomography (PET) imaging studies involving FES in nude mice transplanted with control cells and ERL transfectants. In some of the clones transfected with the inducible-type ERL gene, protein was expressed much higher than in the controls. However, constitutive-type ERL gene-transfected ES cells showed no protein production in spite of their gene expression activity being considerably high. All clones also expressed equal levels of the Oct-3/4 gene, a marker of pluripotency, in comparison with the parental cells. Also, the specific uptake of [ 3 H]-estradiol was over 30 times higher in inducer-treated ERL-expressing ES cells compared to untreated control cells. Finally, by performing dynamic PET imaging, we successfully visualized ERL-expressing teratomas using FES

  15. Report: Studies Addressing EPA’s Organizational Structure

    Science.gov (United States)

    Report #2006-P-00029, August 16, 2006. The 13 studies, articles, publications, and reports we reviewed identified issues with cross-media management, regional offices, reliable information, and reliable science.

  16. Bone marrow transplantations to study gene function in hematopoietic cells

    NARCIS (Netherlands)

    de Winther, Menno P. J.; Heeringa, Peter

    2011-01-01

    Immune cells are derived from hematopoietic stem cells in the bone marrow. Experimental replacement of bone marrow offers the unique possibility to replace immune cells, to study gene function in mouse models of disease. Over the past decades, this technique has been used extensively to study, for

  17. Technical study report on fuel fabrication system

    International Nuclear Information System (INIS)

    Kono, Shusaku; Tanaka, Kenya; Ono, Kiyoshi; Iwasa, Katsuyoshi; Hoshino, Yasushi; Shinkai, Yasuo

    2000-07-01

    The feasibility study of FBR and related fuel cycle is performed for developing the FBR recycle system which ensures safety, economic competitiveness, efficient utilization of resources, reduction of environmental burden and enhancement of nuclear non-proliferation under consistency of FBR reactor and fuel cycle systems. In this study, a conceptual design study and system characteristics evaluation are conducted for fuel fabrication systems of pellet process, vibropack process for oxide and nitride fuel and casting process for metal fuel. Technical issues in each process are also extracted. In 1999 fiscal year, a conceptual design study were conducted for the fuel fabrication plants adopting (1) the short pellet process which simplifies the conventional MOX pellet fabrication processes, (2) vibropack processes of aqueous gelation process, improved RIAR process, improved ANL process and fluoride volatility process, (3) casting processes of injection process, centrifuging process. As a result, attainable perspective was obtained for each fuel fabrication system through the evaluation of apparatuses, layout and facility volume, etc. In each fuel fabrication system, technical issues for practical use were made clear. Hereafter, more detailed study will be performed for each system, and research programs for phase II study will be planned. (author)

  18. Loading functions for assessment of water pollution from nonpoint sources. Final report

    International Nuclear Information System (INIS)

    McElroy, A.D.; Chiu, S.Y.; Nebgen, J.W.; Aleti, A.; Bennett, F.W.

    1976-05-01

    Methods for evaluating the quantity of water pollutants generated from nonpoint sources including agriculture, silviculture, construction, mining, runoff from urban areas and rural roads, and terrestrial disposal are developed and compiled for use in water quality planning. The loading functions, plus in some instances emission values, permit calculation of nonpoint source pollutants from available data and information. Natural background was considered to be a source and loading functions were presented to estimate natural or background loads of pollutants. Loading functions/values are presented for average conditions, i.e., annual average loads expressed as metric tons/hectare/year (tons/acre/year). Procedures for estimating seasonal or 30-day maximum and minimum loads are also presented. In addition, a wide variety of required data inputs to loading functions, and delineation of sources of additional information are included in the report. The report also presents an evaluation of limitations and constraints of various methodologies which will enable the user to employ the functions realistically

  19. Report of the New Rings Study Group

    Energy Technology Data Exchange (ETDEWEB)

    Holmes, S.D.; Dugan, G.; Marriner, J.

    1987-10-19

    We have taken the approach here of trying to understand both the feasibility and practicality of varied options for new rings at Fermilab, rather than trying to produce a single detailed design. In other words, this document is not a design report and should not be construed as such. Our perception of the potential needs for new rings (in order of priority) is as follows: Antiproton Storage and/or Recovery: A facility for storing up to 4 x 10/sup 12/ antiprotons is needed. Recovery of antiprotons from the collider becomes a viable option if the luminosity is indeed dominated by emittance dilution rather than beam loss. New or Post-Booster: The goal here would be to inject into the existing Main Ring above transition. Improved performance of the Main Ring would be anticipated. New Main Ring: Advantages would include better emittance preservation, a faster cycle time for antiproton production, and the removal of interference/backgrounds at the B0 and D0 detectors. We discuss in this paper various scenarios based on one or more combinations of the above possibilities. 14 figs., 10 tabs.

  20. ZINC MITIGATION INTERIM REPORT - THERMODYNAMIC STUDY

    Energy Technology Data Exchange (ETDEWEB)

    Korinko, P.

    2010-12-17

    An experimental program was initiated in order to develop and validate conditions that will effectively trap Zn vapors that are released during extraction. The proposed work is broken down into three tasks. The first task is to determine the effectiveness of various pore sizes of filter elements. The second task is to determine the effect of filter temperature on zinc vapor deposition. The final task is to determine whether the zinc vapors can be chemically bound. The approach for chemically binding the zinc vapors has two subtasks, the first is a review of literature and thermodynamic calculations and the second is an experimental approach using the best candidates. This report details the results of the thermodynamic calculations to determine feasibility of chemically binding the zinc vapors within the furnace module, specifically the lithium trap (1). A review of phase diagrams, literature, and thermodynamic calculations was conducted to determine if there are suitable materials to capture zinc vapor within the lithium trap of the extraction basket. While numerous elements exist that form compounds with zinc, many of these also form compounds with hydrogen or the water that is present in the TPBARs. This relatively comprehensive review of available data indicates that elemental cobalt and copper and molybdenum trioxide (MoO3) may have the requisite properties to capture zinc and yet not be adversely affected by the extraction gases and should be considered for testing.

  1. Report of the New Rings Study Group

    International Nuclear Information System (INIS)

    Holmes, S.D.; Dugan, G.; Marriner, J.

    1987-01-01

    We have taken the approach here of trying to understand both the feasibility and practicality of varied options for new rings at Fermilab, rather than trying to produce a single detailed design. In other words, this document is not a design report and should not be construed as such. Our perception of the potential needs for new rings (in order of priority) is as follows: Antiproton Storage and/or Recovery: A facility for storing up to 4 x 10 12 antiprotons is needed. Recovery of antiprotons from the collider becomes a viable option if the luminosity is indeed dominated by emittance dilution rather than beam loss. New or Post-Booster: The goal here would be to inject into the existing Main Ring above transition. Improved performance of the Main Ring would be anticipated. New Main Ring: Advantages would include better emittance preservation, a faster cycle time for antiproton production, and the removal of interference/backgrounds at the B0 and D0 detectors. We discuss in this paper various scenarios based on one or more combinations of the above possibilities. 14 figs., 10 tabs

  2. Self-reported nonrestorative sleep in fibromyalgia – relationship to impairments of body functions, personal function factors, and quality of life

    Directory of Open Access Journals (Sweden)

    Liedberg GM

    2015-08-01

    Full Text Available Gunilla M Liedberg,1 Mathilda Björk,2 Björn Börsbo31Department of Social and Welfare Studies, Linköping University, Norrköping, 2Rehabilitation Centre and Department of Medical and Health Sciences, 3Rehabilitation Medicine, Department of Medicine and Health Sciences (IMH, Linköping University, Linköping, SwedenPurpose: The purpose of this study was: 1 to determine variables that might characterize good or bad sleep; and 2 to describe the relationship between sleep, impairment of body functions, personal function factors, and quality of life based on quality of sleep in women with fibromyalgia (FM. Methods: This cross-sectional descriptive study included 224 consecutive patients diagnosed at a specialist center. These patients were mailed a questionnaire concerning sleep, body functions, personal factors, and health-related quality of life. In total, 145 completed questionnaires were collected. Results: Using sleep variables (sleep quality, waking up unrefreshed, and tiredness when getting up, we identified two subgroups – the good sleep subgroup and the bad sleep subgroup – of women with FM. These subgroups exhibited significantly different characteristics concerning pain intensity, psychological variables (depressed mood, anxiety, catastrophizing, and self-efficacy, impairments of body functions, and generic and health-related quality of life. The good sleep subgroup reported a significantly better situation, including higher employment/study rate. The bad sleep subgroup reported a greater use of sleep medication. Five variables determined inclusion into either a good sleep or a bad sleep subgroup: pain in the evening, self-efficacy, anxiety, and according to the Short Form health survey role emotional and physical functioning. Conclusion: This study found that it was possible to identify two subgroups of women with FM based on quality of sleep variables. The two subgroups differed significantly with respect to pain, psychological

  3. A (time-dependent) density functional theory study of the optoelectronic properties of bis-triisopropylsilylethynyl-functionalized acenes

    International Nuclear Information System (INIS)

    Malloci, G.; Cappellini, G.; Mulas, G.; Mattoni, A.

    2013-01-01

    We report a comparative study of the optoelectronic properties of small acenes (benzene, anthracene, and pentacene) and their bis-triisopropylsilylethynyl (TIPS) functionalized counterparts. We computed the fundamental gap using density functional theory (DFT) in the framework of the ΔSCF scheme, and the optical absorption spectra by means of time-dependent DFT. Upon TIPS functionalization we observed a lowering of the ionization energy and a rise of the electron affinity; we consequently predict a systematic reduction of the fundamental electronic gap which decreases from ∼ 40% for benzene to ∼ 16% for pentacene. This trend is reflected in the computed optical absorption spectra: for all TIPS-molecules the onset of absorption is red-shifted as compared to their plain precursors. In the case of TIPS-pentacene, in particular, the computed spectrum agrees with the available experimental data. - Highlights: • We evaluate the effect of triisopropylsilylethynyl (TIPS)-substitution on acenes. • We compared the fundamental gap and the optical absorption as a function of size. • We found a general gap reduction following TIPS functionalization. • The gap reduction decreases at increasing size, from 40% for n = 1 to 16% for n = 5. • The onset of absorption is red-shifted as compared to TIPS precursors

  4. A (time-dependent) density functional theory study of the optoelectronic properties of bis-triisopropylsilylethynyl-functionalized acenes

    Energy Technology Data Exchange (ETDEWEB)

    Malloci, G., E-mail: giuliano.malloci@dsf.unica.it [Istituto Officina dei Materiali (CNR-IOM), Unità di Cagliari, Cittadella Universitaria, I-09042 Monserrato (Italy); Cappellini, G. [Istituto Officina dei Materiali (CNR-IOM), Unità di Cagliari, Cittadella Universitaria, I-09042 Monserrato (Italy); Dipartimento di Fisica, Università degli Studi di Cagliari, Cittadella Universitaria, I-09042 Monserrato (Italy); Mulas, G. [INAF-Osservatorio Astronomico di Cagliari, Strada 54, Località Poggio dei Pini, I-09012 Capoterra (Italy); Mattoni, A. [Istituto Officina dei Materiali (CNR-IOM), Unità di Cagliari, Cittadella Universitaria, I-09042 Monserrato (Italy)

    2013-09-30

    We report a comparative study of the optoelectronic properties of small acenes (benzene, anthracene, and pentacene) and their bis-triisopropylsilylethynyl (TIPS) functionalized counterparts. We computed the fundamental gap using density functional theory (DFT) in the framework of the ΔSCF scheme, and the optical absorption spectra by means of time-dependent DFT. Upon TIPS functionalization we observed a lowering of the ionization energy and a rise of the electron affinity; we consequently predict a systematic reduction of the fundamental electronic gap which decreases from ∼ 40% for benzene to ∼ 16% for pentacene. This trend is reflected in the computed optical absorption spectra: for all TIPS-molecules the onset of absorption is red-shifted as compared to their plain precursors. In the case of TIPS-pentacene, in particular, the computed spectrum agrees with the available experimental data. - Highlights: • We evaluate the effect of triisopropylsilylethynyl (TIPS)-substitution on acenes. • We compared the fundamental gap and the optical absorption as a function of size. • We found a general gap reduction following TIPS functionalization. • The gap reduction decreases at increasing size, from 40% for n = 1 to 16% for n = 5. • The onset of absorption is red-shifted as compared to TIPS precursors.

  5. Mirror Advanced Reactor Study interim design report

    Energy Technology Data Exchange (ETDEWEB)

    1983-04-01

    The status of the design of a tenth-of-a-kind commercial tandem-mirror fusion reactor is described at the midpoint of a two-year study. When completed, the design is to serve as a strategic goal for the mirror fusion program. The main objectives of the Mirror Advanced Reactor Study (MARS) are: (1) to design an attractive tandem-mirror fusion reactor producing electricity and synfuels (in alternate versions), (2) to identify key development and technology needs, and (3) to exploit the potential of fusion for safety, low activation, and simple disposal of radioactive waste. In the first year we have emphasized physics and engineering of the central cell and physics of the end cell. Design optimization and trade studies are continuing, and we expect additional modifications in the end cells to further improve the performance of the final design.

  6. Technical study report on reprocessing system

    International Nuclear Information System (INIS)

    Tanaka, Hiroshi; Kasai, Yoshimitsu; Kawamura, Fumio

    2000-07-01

    The feasibility studies on commercialized fast breeder reactor (FBR) recycle system, in which reactor system and recycle technologies are related on consideration, are performed considering the attainable perspectives for the followings: ensuring safety, economic competitiveness to future LWRs, efficient utilization of resources, reduction of environmental burden, and enhancement of nuclear non-proliferation. In the studies of Reprocessing system of FBR, evaluation was made for the non-aqueous reprocessing of pyrochemical and fluoride volatility process and also for the aqueous reprocessing with a view to streamlining. As a result, it was estimated that each system has prospects of coming into practical use in terms of technique. In the economical efficiency assessment, it was estimated to have economic competitiveness to future LWRs. And the technical research items of each system are picked out. Hereafter, more detail design study will be performed for each system. (author)

  7. Mirror Advanced Reactor Study interim design report

    International Nuclear Information System (INIS)

    1983-04-01

    The status of the design of a tenth-of-a-kind commercial tandem-mirror fusion reactor is described at the midpoint of a two-year study. When completed, the design is to serve as a strategic goal for the mirror fusion program. The main objectives of the Mirror Advanced Reactor Study (MARS) are: (1) to design an attractive tandem-mirror fusion reactor producing electricity and synfuels (in alternate versions), (2) to identify key development and technology needs, and (3) to exploit the potential of fusion for safety, low activation, and simple disposal of radioactive waste. In the first year we have emphasized physics and engineering of the central cell and physics of the end cell. Design optimization and trade studies are continuing, and we expect additional modifications in the end cells to further improve the performance of the final design

  8. Improving gross motor function and postural control with hippotherapy in children with Down syndrome: case reports.

    Science.gov (United States)

    Champagne, Danielle; Dugas, Claude

    2010-11-01

    The purpose of this case report is to describe the impact of an 11-week hippotherapy program on the gross motor functions of two children (respectively 28 and 37 months old) diagnosed with Down syndrome. Hippotherapy is a strategy that uses the horse's motion to stimulate and enhance muscle contraction and postural control. The children were assessed by the Gross Motor Function Measure (GMFM) and accelerometry. The results indicate that both children improved on many dimensions of the GMFM. Power spectral analysis of the acceleration signals showed improvement in postural control of either the head or trunk, because the children adopted two different adaptative strategies to perturbation induced by the moving horse.

  9. Wild steelhead studies. 1993 Annual report

    International Nuclear Information System (INIS)

    Holubetz, T.B.

    1995-11-01

    Significant progress was attained in implementing the complex and challenging studies of wild steelhead Oncorhynchus mykiss production in Idaho. Study sites were selected and techniques were developed to collect the needed data in remote wilderness locations. Cursory examination of existing data provides indication that most wild steelhead stocks are under escaped, especially the Group B stocks. Abundance of wild steelhead is generally declining in recent years. The portable weir concept and electronic fish counting developed through this project have been well received by land owners and reviewing governmental agencies with less impact to the land, stream, and fishery resources than conventional permanent weirs

  10. Exploratory Shaft Facility design basis study report

    International Nuclear Information System (INIS)

    Langstaff, A.L.

    1987-01-01

    The Design Basis Study is a scoping/sizing study that evaluated the items concerning the Exploratory Shaft Facility Design including design basis values for water and methane inflow; flexibility of the design to support potential changes in program direction; cost and schedule impacts that could result if the design were changed to comply with gassy mine regulations; and cost, schedule, advantages and disadvantages of a larger second shaft. Recommendations are proposed concerning water and methane inflow values, facility layout, second shaft size, ventilation, and gassy mine requirements. 75 refs., 3 figs., 7 tabs

  11. The Danish National Case Study Report

    DEFF Research Database (Denmark)

    Brodersen, Søsser; Jørgensen, Michael Søgaard

    the projects so it fits into the university schedule, without leaving out the time perspective of the clients, and secure the research is applicable for the clients and based on their need for knowledge. The case studies have shown different roles of a Science Shop. All Science Shops have a role as mediator...

  12. External wave-launcher study. Final report

    International Nuclear Information System (INIS)

    1983-01-01

    The rationale for liquid dielectrically-loaded external wave-guide launchers is discussed. The arguments are strongly indicative that a liquid dielectric-filled waveguide system could be a practical technique for launching ICRH power into a fusion reactor. A detailed summary of the work performed in the study is presented

  13. Local Skills Case Study. Research Report

    Science.gov (United States)

    Green, Anne; Hogarth, Terence; Thom, Graham; MacLeod, Katie; Warhurst, Chris; Willis, Robert; Mackay, Susan

    2017-01-01

    This study, jointly conducted by the University of Warwick Institute for Employment Research (IER) and SQW Ltd., discusses the UK Government's intention to accelerate the process of ceding more responsibility for delivering a range of services to the local level. The logic is that local actors are better placed to identify local priorities. This…

  14. Climate wise case study compendium: Report 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-02-01

    This case study compendium is one of several Climate Wise tools available to help interested companies identify cost-effective options. Climate Wise, a private-public partnership program, is a key Federal initiative to return greenhouse gas emissions to 1990 levels by 2000.

  15. Laser fusion system design study. Final report

    International Nuclear Information System (INIS)

    1975-01-01

    The following studies were completed: (1) The synthesis of a pointing/control system compatible with existing and advanced laser opto-mechanical configurations. (2) Attainment of the required pointing angle, longitudinal focus, and differential pathlength accuracies. (3) Maximum modularization of the sensor and gimbal assemblies to provide the required accuracies at minimum cost. Detailed information is given on each. (MOW)

  16. Nuclear safety code study. Final report

    International Nuclear Information System (INIS)

    Jackson, C.; Abumansoor, K.; Myers, E.; Jespersen, D.; Cramer, E.; O'Reilly, B.; Carmichael, B.

    1980-06-01

    An unprotected overpower accident in a Liquid Metal Fast Breeder Reactor is studied. A mathematical model and a system of partial differential equations for the temperature are derived. After spatial discretization, a large system of ordinary differential equations is obtained. The steady state version of the equations is solved analytically

  17. Report of the Public Cryptography Study Group.

    Science.gov (United States)

    American Council on Education, Washington, DC.

    Concerns of the National Security Agency (NSA) that information contained in some articles about cryptography in learned and professional journals and in monographs might be inimical to the national security are addressed. The Public Cryptography Study Group, with one dissenting opinion, recommends that a voluntary system of prior review of…

  18. Coordination: Southeast Continental Shelf studies. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Menzel, D.W.

    1981-02-01

    An overview of the Oceanograhic Program of Skidaway Institute of Oceanograhy is presented. Included are the current five year plan for studies of the Southeast Continental Shelf, a summary of research accomplishments, proposed research for 1981-1982, current status of the Savannah Navigational Light Tower, and a list of publications. (ACR)

  19. Bond Feasibility Study. Project Identification Committee Report.

    Science.gov (United States)

    Wichita Public Schools, KS.

    A committee, appointed by the Board of Education, was requested to make a comprehensive study of the school building needs of Unified School District No. 259. In an attempt to determine the feasibility of a general bond election to upgrade the public schools, the specific charge to the committee was to evaluate the needs for physical plant…

  20. Day-to-day variations in health behaviors and daily functioning: two intensive longitudinal studies.

    Science.gov (United States)

    Flueckiger, Lavinia; Lieb, Roselind; Meyer, Andrea H; Witthauer, Cornelia; Mata, Jutta

    2017-04-01

    In two intensive longitudinal studies we examined the daily dynamics in health behaviors and their associations with two important indicators of young adults' daily functioning, namely, affect and academic performance. Over a period of 8 months, university students (Study 1: N = 292; Study 2: N = 304) reported sleep, physical activity, snacking, positive and negative affect, and learning goal achievement. A subsample wore an actigraph to provide an additional measurement of sleep and physical activity and participated in a controlled laboratory snacking situation. Multilevel structural equation models showed that better day-to-day sleep quality or more physical activity than usual, but not snacking, were associated with improved daily functioning, namely, affect and learning goal achievement. Importantly, self-report measurements of health behaviors correlated with behavioral measurements. These findings have the potential to inform health promotion programs aimed at supporting young adults in their daily functioning in good physical and mental health.

  1. Accelerator research studies: Progress report, Task B

    International Nuclear Information System (INIS)

    1985-06-01

    The main objectives in Task B of the research program are summarized as follows: (1) studies of the collective acceleration of positive ions from a localized plasma source by an intense relativistic electron beam (IREB), (2) studies of ways in which external control may be achieved over the electron beam front in order to achieve higher ion energies - the Beam Front Accelerator (BFA) concept, and (3) study of electron and ion beam generation in a new kind of compact pulsed accelerator in which energy is stored inductively and switched using a plasma focus opening switch. During the past year, substantial progress was made in each of these areas. Our exploratory research on the collective acceleration of laser-produced ions has confirmed the acceleration of C, Al, and Fe ions to peak energies in excess of 10 MeV/amu. In addition, studies of the relation between collective ion acceleration and electron beam propagation in vacuum have shed new light on the experimental processes that lead to energy transfer from electrons to ions. Meanwhile, extensive progress has been made in our attempts to use analytical theory and numerical simulation to model ion acceleration in these systems. Our resultant improved understanding of the processes that limit the peak ion energy has had a profound impact on our plans for further research in this area. Studies of the Compact Pulsed Accelerator have included both ion and electron beam extraction from the device. Its potential to reduce the volume of pulse power sources by an order of magnitude has already been demonstrated, and plans are currently underway to scale the experiment up to voltages in the 1 MV range

  2. Autonomic nervous system function in patients with functional abdominal pain. An experimental study

    DEFF Research Database (Denmark)

    Jørgensen, L S; Christiansen, P; Raundahl, U

    1993-01-01

    Functional abdominal pain--that is, pain without demonstrable organic abnormalities--has often been associated with psychologic stress. The aim of the present study was to investigate whether sympathetic nervous system response to laboratory stress and basal parasympathetic neural activity were...

  3. Lung function in type 2 diabetes: the Normative Aging Study.

    Science.gov (United States)

    Litonjua, Augusto A; Lazarus, Ross; Sparrow, David; Demolles, Debbie; Weiss, Scott T

    2005-12-01

    Cross-sectional studies have noted that subjects with diabetes have lower lung function than non-diabetic subjects. We conducted this analysis to determine whether diabetic subjects have different rates of lung function change compared with non-diabetic subjects. We conducted a nested case-control analysis in 352 men who developed diabetes and 352 non-diabetic subjects in a longitudinal observational study of aging in men. We assessed lung function among cases and controls at three time points: Time0, prior to meeting the definition of diabetes; Time1, the point when the definition of diabetes was met; and Time2, the most recent follow-up exam. Cases had lower forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC) at all time points, even with adjustment for age, height, weight, and smoking. In multiple linear regression models adjusting for relevant covariates, there were no differences in rates of FEV1 or FVC change over time between cases and controls. Men who are predisposed to develop diabetes have decreased lung function many years prior to the diagnosis, compared with men who do not develop diabetes. This decrement in lung function remains after the development of diabetes. We postulate that mechanisms involved in the insulin resistant state contribute to the diminished lung function observed in our subjects.

  4. Relations Between Self-reported Executive Functioning and Speech Perception Skills in Adult Cochlear Implant Users.

    Science.gov (United States)

    Moberly, Aaron C; Patel, Tirth R; Castellanos, Irina

    2018-02-01

    As a result of their hearing loss, adults with cochlear implants (CIs) would self-report poorer executive functioning (EF) skills than normal-hearing (NH) peers, and these EF skills would be associated with performance on speech recognition tasks. EF refers to a group of high order neurocognitive skills responsible for behavioral and emotional regulation during goal-directed activity, and EF has been found to be poorer in children with CIs than their NH age-matched peers. Moreover, there is increasing evidence that neurocognitive skills, including some EF skills, contribute to the ability to recognize speech through a CI. Thirty postlingually deafened adults with CIs and 42 age-matched NH adults were enrolled. Participants and their spouses or significant others (informants) completed well-validated self-reports or informant-reports of EF, the Behavior Rating Inventory of Executive Function - Adult (BRIEF-A). CI users' speech recognition skills were assessed in quiet using several measures of sentence recognition. NH peers were tested for recognition of noise-vocoded versions of the same speech stimuli. CI users self-reported difficulty on EF tasks of shifting and task monitoring. In CI users, measures of speech recognition correlated with several self-reported EF skills. The present findings provide further evidence that neurocognitive factors, including specific EF skills, may decline in association with hearing loss, and that some of these EF skills contribute to speech processing under degraded listening conditions.

  5. Relationship between lower limb muscle strength, self-reported pain and function, and frontal plane gait kinematics in knee osteoarthritis.

    Science.gov (United States)

    Park, Sang-Kyoon; Kobsar, Dylan; Ferber, Reed

    2016-10-01

    The relationship between muscle strength, gait biomechanics, and self-reported physical function and pain for patients with knee osteoarthritis is not well known. The objective of this study was to investigate these relationships in this population. Twenty-four patients with knee osteoarthritis and 24 healthy controls were recruited. Self-reported pain and function, lower-limb maximum isometric force, and frontal plane gait kinematics during treadmill walking were collected on all patients. Between-group differences were assessed for 1) muscle strength and 2) gait biomechanics. Linear regressions were computed within the knee osteoarthritis group to examine the effect of muscle strength on 1) self-reported pain and function, and 2) gait kinematics. Patients with knee osteoarthritis exhibited reduced hip external rotator, knee extensor, and ankle inversion muscle force output compared with healthy controls, as well as increased peak knee adduction angles (effect size=0.770; p=0.013). Hip abductor strength was a significant predictor of function, but not after controlling for covariates. Ankle inversion, hip abduction, and knee flexion strength were significant predictors of peak pelvic drop angle after controlling for covariates (34.4% unique variance explained). Patients with knee osteoarthritis exhibit deficits in muscle strength and while they play an important role in the self-reported function of patients with knee osteoarthritis, the effect of covariates such as sex, age, mass, and height was more important in this relationship. Similar relationships were observed from gait variables, except for peak pelvic drop, where hip, knee, and ankle strength remained important predictors of this variable after controlling for covariates. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. A density functional theory study on redox reaction of uranium

    International Nuclear Information System (INIS)

    Toraishi, T.; Kawaguchi, M.; Tsuneda, T.; Tanaka, S.; Nagasaki, S.

    2005-01-01

    Full text of publication follows: Redox reactions are key issues for predicting the migration behavior of actinides in the geosphere, and therefore the chemical processes have to be profoundly understood. However, redox reactions basically involve several elemental processes, and in many cases only limited chemical information can be obtained experimentally. A theoretical approach gives further information which never can be obtained by experiments, such as precise thermodynamic data or reaction pathways of very rapid charge transfer reactions. For this reason, ab initio MO calculations have been applied in the last 5-6 years to the elucidation of redox processes in the U(VI)-Fe(II) or U(VI)-U(IV) system [1- 3]. Those studies provided extremely important chemical information. Nevertheless, the 'huge' calculation costs of ab initio MO techniques now interfere with the extension of the calculation to the 'real' size system: In order to deal with the practically important chemical reactions such as the reduction of actinides at solid surfaces, a large chemical system involving many atoms (electrons) has to be treated. Present ab initio MO techniques at CASSCF, CASPT2 or MRCI level, however, do not allow to handle such a large systems because of the high calculation costs. Density functional theory (DFT) calculations should be also feasible for such systems. Nevertheless, there are very few reports on redox processes of actinides calculated by DFT. This fact was based on the argument that DFT could not treat charge transfer phenomena accurately since the two-electron exchange integral term is not explicitly involved [1-3]. However this is no longer correct: the long-range corrected (LC) energy function was recently developed, and now the charge transfer reaction can safely be calculated by DFT [4]. In the present work, we employ the DFT technique to treat the reduction of U(VI) to U(V) by Fe(II) via the bi-nuclear complex system, and confirm the applicability of the

  7. Multiple Past Concussions in High School Football Players: Are There Differences in Cognitive Functioning and Symptom Reporting?

    Science.gov (United States)

    Brooks, Brian L; Mannix, Rebekah; Maxwell, Bruce; Zafonte, Ross; Berkner, Paul D; Iverson, Grant L

    2016-12-01

    There is increasing concern about the possible long-term effects of multiple concussions, particularly on the developing adolescent brain. Whether the effect of multiple concussions is detectable in high school football players has not been well studied, although the public health implications are great in this population. To determine if there are measureable differences in cognitive functioning or symptom reporting in high school football players with a history of multiple concussions. Cross-sectional study; Level of evidence, 3. Participants included 5232 male adolescent football players (mean [±SD] age, 15.5 ± 1.2 years) who completed baseline testing between 2009 and 2014. On the basis of injury history, athletes were grouped into 0 (n = 4183), 1 (n = 733), 2 (n = 216), 3 (n = 67), or ≥4 (n = 33) prior concussions. Cognitive functioning was measured by the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) battery, and symptom ratings were obtained from the Post-Concussion Symptom Scale. There were no statistically significant differences between groups (based on the number of reported concussions) regarding cognitive functioning. Athletes with ≥3 prior concussions reported more symptoms than did athletes with 0 or 1 prior injury. In multivariate analyses, concussion history was independently related to symptom reporting but less so than developmental problems (eg, attention or learning problems) or other health problems (eg, past treatment for psychiatric problems, headaches, or migraines). In the largest study to date, high school football players with multiple past concussions performed the same on cognitive testing as those with no prior concussions. Concussion history was one of several factors that were independently related to symptom reporting. © 2016 The Author(s).

  8. What Is Next for Functional Requirements for Bibliographic Records? A Delphi Study

    Science.gov (United States)

    Zhang, Yin; Salaba, Athena

    2009-01-01

    This article reports on a Delphi study conducted to determine key issues and challenges facing Functional Requirements for Bibliographic Records (FRBR) research and practice. The Delphi panel consisted of thirty-three experts in the field who participated in a three-round issue-raising and consensus-building process via a Web-based survey…

  9. Lung function studied by servo-controlled ventilator and respiratory mass spectrometer

    International Nuclear Information System (INIS)

    Piiper, J.

    1987-01-01

    The gas exchange function of lungs is studied. The gas concentration, measured by mass spectrometry and the lung volume and rate of change of lung volume are discussed. A servo-controlled ventilator is presented. Several experimental projects performed on anesthetized paralyzed dogs are reported. (M.A.C.) [pt

  10. Pulmonary function studies in young healthy Malaysians of Kelantan, Malaysia.

    Science.gov (United States)

    Bandyopadhyay, Amit

    2011-11-01

    Pulmonary function tests have been evolved as clinical tools in diagnosis, management and follow up of respiratory diseases as it provides objective information about the status of an individual's respiratory system. The present study was aimed to evaluate pulmonary function among the male and female young Kelantanese Malaysians of Kota Bharu, Malaysia, and to compare the data with other populations. A total of 128 (64 males, 64 females) non-smoking healthy young subjects were randomly sampled for the study from the Kelantanese students' population of the University Sains Malaysia, Kota Bharu Campus, Kelantan, Malaysia. The study population (20-25 yr age group) had similar socio-economic background. Each subject filled up the ATS (1978) questionnaire to record their personal demographic data, health status and consent to participate in the study. Subjects with any history of pulmonary diseases were excluded from the study. The pulmonary function measurements exhibited significantly higher values among males than the females. FEV 1% did not show any significant inter-group variation probably because the parameter expresses FEV 1 as a percentage of FVC. FVC and FEV 1 exhibited significant correlations with body height and body mass among males whereas in the females exhibited significant correlation with body mass, body weight and also with age. FEV 1% exhibited significant correlation with body height and body mass among males and with body height in females. FEF 25-75% did not show any significant correlation except with body height among females. However, PEFR exhibited significant positive correlation with all the physical parameters except with age among the females. On the basis of the existence of significant correlation between different physical parameters and pulmonary function variables, simple and multiple regression norms have been computed. From the present investigation it can be concluded that Kelantanese Malaysian youths have normal range of

  11. Rain scavenging studies. Progress report No. 11

    International Nuclear Information System (INIS)

    Dingle, A.N.

    1975-05-01

    The modeling of convective storm scavenging processes is going forward on two distinct fronts. The first of these relates to the microphysical processes, particularly to the study of their response to micro-dynamical components of the convective circulation. It is found that the droplet size spectra generated are responsive to variations of vertical velocity due to turbulence within the cloud and to humidity variations due to entrainment processes. Both sets of variations give responses that differ for different amplitudes and frequencies, i.e., rapid, small-amplitude eddies appear to enhance small-droplet development, whereas slow, large-amplitude oscillations tend to enhance large-droplet development. An allied study of the assumptions used in the microphysical equations is also being made. The second modeling effort is addressed to the problem of three-dimensional representation of convective dynamics. Equations are presented, and some of the problems under attack are discussed

  12. Fusion reactor remote maintenance study. Final report

    International Nuclear Information System (INIS)

    Sniderman, M.

    1979-04-01

    An analysis of a major maintenance operation, the remote replacement of a modular sector of a tokamak reactor, was performed in substantial detail. Specific assumptions were developed which included concepts from various existing designs so that the operation which was studied includes some design features generic to any fusion reactor design. Based on the work performed in this study, the principal conclusions are: (1) It appears feasible to design a tokamak fusion reactor plant with availability comparable to existing fossil and fission plants, but this will require diligence and comprehensive planning during the complete design phase. (2) Since the total fusion program is paced by the success of each device, maintenance considerations must be incorporated into each device during design, even if the device is an experimental unit. (3) Innovative approaches, such as automatic computer controlled operations, should be developed so that large step reductions in planned maintenance times can be achieved

  13. Commercial gasifier for IGCC applications study report

    Energy Technology Data Exchange (ETDEWEB)

    Notestein, J.E.

    1990-06-01

    This was a scoping-level study to identify and characterize the design features of fixed-bed gasifiers appearing most important for a gasifier that was to be (1) potentially commercially attractive, and (2) specifically intended for us in integrated coal gasification/combined-cycle (IGCC) applications. It also performed comparative analyses on the impact or value of these design features and on performance characteristics options of the whole IGCC system since cost, efficiency, environmental traits, and operability -- on a system basis -- are what is really important. The study also reviewed and evaluated existing gasifier designs, produced a conceptual-level gasifier design, and generated a moderately advanced system configuration that was utilized as the reference framework for the comparative analyses. In addition, technical issues and knowledge gaps were defined. 70 figs., 31 tabs.

  14. Accelerator research studies: Annual progress report

    International Nuclear Information System (INIS)

    1988-01-01

    Our major goal in this experiment is to study the physics of a space-charge dominated beam propagating through a long, periodic transport channel consisting in our case of 38 solenoid lenses two of which are being used to match the beam from the gun into the periodic lattice. In addition, a small separate test stand gives us the capability of studying different electron gun designs including measurements of beam perveance and emittance, beam propagation in drift space and through a single solenoid lens. Most of our transport studies in the periodic channel have been conducted with a 5 keV, 200 mA electron beam from a gun with a 1-inch diameter thermionic cathode. The beam physics phenomena of greatest interest are instabilities due to resonant interaction between the beam and the periodic lattice, non-linear effects due to external forces (e.g., spherical lens aberrations) or due to nonuniform charge distributions, beam off-centering and misalignments which also include the effects of image forces. In principle, all of these effects may lead to emittance growth and beam loss. An important question is whether there exists a ''window'' of 100% transmission and minimal emittance growth in such a long periodic channel. 28 refs

  15. Progress report on nuclear spectroscopic studies

    International Nuclear Information System (INIS)

    Bingham, C.R.; Guidry, M.W.; Riedinger, L.L.; Sorensen, S.P.

    1994-01-01

    The Nuclear Physics group at the University of Tennessee, Knoxville (UTK) is involved in several aspects of heavy-ion physics including both nuclear structure and reaction mechanisms. While the main emphasis is on experimental problems, the authors have maintained a strong collaboration with several theorists in order to best pursue the physics of their measurements. During the last year they have had several experiments at the ATLAS at Argonne National Laboratory, the GAMMASPHERE at the LBL 88 Cyclotron, and with the NORDBALL at the Niels Bohr Institute Tandem. Also, they continue to be very active in the WA93/98 collaboration studying ultra-relativistic heavy ion physics utilizing the SPS accelerator at CERN in Geneva, Switzerland and in the PHENIX Collaboration at the RHIC accelerator under construction at Brookhaven National Laboratory. During the last year their experimental work has been in three broad areas: (1) the structure of nuclei at high angular momentum, (2) the structure of nuclei far from stability, and (3) ultra-relativistic heavy-ion physics. The results of studies in these particular areas are described in this document. These studies concentrate on the structure of nuclear matter in extreme conditions of rotational motion, imbalance of neutrons and protons, or very high temperature and density. Another area of research is heavy-ion-induced transfer reactions, which utilize the transfer of nucleons to states with high angular momentum to learn about their structure and to understand the transfer of particles, energy, and angular momentum in collisions between heavy ions

  16. Renewable Energy Feasibility Study Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Rooney, Tim [Antares Group Inc.

    2013-10-30

    The Gila River Indian Community (GRIC or the Community) contracted the ANTARES Group, Inc. (“ANTARES”) to assess the feasibility of solar photovoltaic (PV) installations. A solar energy project could provide a number of benefits to the Community in terms of potential future energy savings, increased employment, environmental benefits from renewable energy generation and usage, and increased energy self-sufficiency. The study addresses a number of facets of a solar project’s overall feasibility, including: Technical appropriateness; Solar resource characteristics and expected system performance; Levelized cost of electricity (LCOE) economic assessment. The Gila River Indian Community (GRIC or the Community) contracted the ANTARES Group, Inc. (“ANTARES”) to prepare a biomass resource assessment study and evaluate the feasibility of a bioenergy project on Community land. A biomass project could provide a number of benefits to the Community in terms of increased employment, environmental benefits from renewable energy generation and usage, and increased energy self-sufficiency. The study addresses a number of facets of a biomass project’s overall feasibility, including: Resource analysis and costs; Identification of potential bioenergy projects; Technical and economic (levelized cost of energy) modeling for selected project configuration.

  17. Brain Functional Connectivity in MS: An EEG-NIRS Study

    Science.gov (United States)

    2015-10-01

    1 AWARD NUMBER: W81XWH-14-1-0582 TITLE: Brain Functional Connectivity in MS: An EEG -NIRS Study PRINCIPAL INVESTIGATOR: Heather Wishart...Functional Connectivity in MS: An EEG -NIRS Study 5b. GRANT NUMBER W81XWH-14-1-0582 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER Heather...electrical ( EEG ) and blood volume and blood oxygen-based (NIRS and fMRI) signals, and to use the results to help optimize blood oxygen level

  18. Sex after seventy: a pilot study of sexual function in older persons.

    Science.gov (United States)

    Smith, Lizette J; Mulhall, John P; Deveci, Serkan; Monaghan, Niall; Reid, M C

    2007-09-01

    Limited information is available regarding sexual functioning among adults aged 70 years and older. To assess sexual functioning among older men and women, and ascertain patient-physician communication patterns about sexual functioning. Prospective participants were approached prior to scheduled appointments with their primary care physician. In-depth sexual histories were obtained along with data on their demographic, medical, psychological, and cognitive status. Sexual functioning was assessed using standardized questionnaires, and simple yes/no questions were administered to ascertain information regarding patient-physician communication practices about sex. Of the 74 eligible patients approached, 50 (68%) participated. The participants had a mean age +/- standard deviation (SD) of 81 +/- 6 years and most (56%) were women. Eighteen percent of the women and 41% of the men were sexually active. The most commonly reported sexual activity was intercourse for men and masturbation for women. Among the women, the most commonly cited reason for being sexually inactive was "no desire," whereas for most men, it was "erectile dysfunction." Sexual function scores for women were low across each category (lubrication, desire, orgasm, arousal, pain, and satisfaction.) For men, low sexual function scores were found in the domains of erectile function, orgasm, and overall satisfaction, but not desire. Only 4% of the women (vs. 36% of men) reported initiating a discussion about sexual function with their physician in the past year, whereas 7% of the women (vs. 32% of men) reported that their physician inquired about the topic in the preceding year. Finally, 32% of the women (vs. 86% of men) felt that physicians should initiate discussions about sexual function. In this study of older adults, a minority reported current sexual activity. Among sexually inactive women, most did not wish to resume activity, whereas desire for sexual activity remained high among men, despite

  19. Automated diagnostics scoping study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Quadrel, R.W.; Lash, T.A.

    1994-06-01

    The objective of the Automated Diagnostics Scoping Study was to investigate the needs for diagnostics in building operation and to examine some of the current technologies in automated diagnostics that can address these needs. The study was conducted in two parts. In the needs analysis, the authors interviewed facility managers and engineers at five building sites. In the technology survey, they collected published information on automated diagnostic technologies in commercial and military applications as well as on technologies currently under research. The following describe key areas that the authors identify for the research, development, and deployment of automated diagnostic technologies: tools and techniques to aid diagnosis during building commissioning, especially those that address issues arising from integrating building systems and diagnosing multiple simultaneous faults; technologies to aid diagnosis for systems and components that are unmonitored or unalarmed; automated capabilities to assist cause-and-effect exploration during diagnosis; inexpensive, reliable sensors, especially those that expand the current range of sensory input; technologies that aid predictive diagnosis through trend analysis; integration of simulation and optimization tools with building automation systems to optimize control strategies and energy performance; integration of diagnostic, control, and preventive maintenance technologies. By relating existing technologies to perceived and actual needs, the authors reached some conclusions about the opportunities for automated diagnostics in building operation. Some of a building operator`s needs can be satisfied by off-the-shelf hardware and software. Other needs are not so easily satisfied, suggesting directions for future research. Their conclusions and suggestions are offered in the final section of this study.

  20. Preliminary systems design study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Feizollahi, F.; Del Signore, J.C.

    1991-09-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept

  1. WP4 CASE STUDY Report: Living Knowledge

    DEFF Research Database (Denmark)

    Dorland, Jens; Jørgensen, Michael Søgaard

    Science Shops can be regarded as a platform for bringing together scientific analytical principles on the one hand, and the lay persons’ (with or without scientific background) knowledge about the issue on the other, thus contributing theoretically based systemization of lay knowledge or problem...... conception and lay insights on perceived problems to science. Science shops are an interesting entity to study to see what kind of long-term impacts they have implied as an initiative which has been running since the 80’ties, and how CSO’s have been empowered through the relationship with the university....

  2. GCFR upflow/downflow study summary report

    International Nuclear Information System (INIS)

    Menzel, H.F.

    1979-08-01

    During the one-year study a conceptual upflow core plant design was developed and the downflow core plant reference design updated. A comparison was made between the two plant designs in critical areas of plant performance, safety, and licensing. The results of that comparison led to the recommendation to adopt an upflow core for the GCFR plant reference design. Although additional development and design efforts are required, the potential of residual heat removal by natural circulation alone offers a decisive safety and licensing advantage

  3. FY 1999 report on the results of the introductory study on the global environmental industry technology. Investigational study on the environmental creation technology by the application of ecosystem information functions; 1999 nendo chikyu kankyo sangyo gijutsu ni kakawaru sendo kenkyu seika hokokusho. Seitaikei joho kino oyo ni yoru kankyo sozo gijutsu ni kansuru chosa kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    To know the state of environmental pollution before it clearly exists, an investigational study was made on the technology to measure environmental stress at high sensitivity, in wide range and at high speed using functions to respond chemical substances, etc. which living organisms have. The FY 1999 results were outlined. As to the application of ecosystem information functions, survey was conduced paying attention to the environmental stress response of each of the bacteria, algae, plants and animals, responses viewed from the manifestation of immunity antibodies which occurs inside living organisms and changes at genetic level, and responses of algae and plants in case of specifying environmental pollutants. In relation to the application of the biological amplification mechanism, survey was carried out on environmental stress signals sent from plants, selection of environmental stress index plants, detection of environmental pollutants using bacteria, high sensitivity detection using animal (nematode), etc. Concerning the standardization of the environmental measuring technology by the application of ecosystem information functions, survey was conducted on artificial molecular recognition sensor, antibody device sensor, biochips, system construction, etc. (NEDO)

  4. Cementitious waste option scoping study report

    International Nuclear Information System (INIS)

    Lee, A.E.; Taylor, D.D.

    1998-02-01

    A Settlement Agreement between the Department of Energy (DOE) and the State of Idaho mandates that all high-level radioactive waste (HLW) now stored at the Idaho Chemical Processing Plant (ICPP) on the Idaho National Engineering and Environmental Laboratory (INEEL) will be treated so that it is ready to be moved out of Idaho for disposal by a target date of 2035. This study investigates the nonseparations Cementitious Waste Option (CWO) as a means to achieve this goal. Under this option all liquid sodium-bearing waste (SBW) and existing HLW calcine would be recalcined with sucrose, grouted, canisterized, and interim stored as a mixed-HLW for eventual preparation and shipment off-Site for disposal. The CWO waste would be transported to a Greater Confinement Disposal Facility (GCDF) located in the southwestern desert of the US on the Nevada Test Site (NTS). All transport preparation, shipment, and disposal facility activities are beyond the scope of this study. CWO waste processing, packaging, and interim storage would occur over a 5-year period between 2013 and 2017. Waste transport and disposal would occur during the same time period

  5. Mined salt storage feasibility: Engineering study report

    International Nuclear Information System (INIS)

    1987-07-01

    This study addresses a method of eliminating the surface storage of mined salt at the Deaf Smith repository site. It provides rough estimates of the logistics and costs of transporting 3.7 million tons of salt from the repository to the salt disposal site near Carlsbad, New Mexico and returning it to the repository for decommissioning backfill. The study assumes that a railcar/truck system will be installed and that the excavated salt will be transported from the repository to an existing potash mine located near Carlsbad, New Mexico approximately 300 miles from the repository. The 3.7 million tons of salt required for repository decommissioning backfill can be stored in the potash mines along with the excess salt, with no additional capital costs required for either a railcar or a truck transportation system. The capital cost for facilities to reclaim the 3.7 million tons of salt from the potash mine is estimated to be $4,400,000 with either a rail or truck transportation system. Segregating the 3.7 million tons of backfill salt in a surface storage area at the potash mine requires a capital cost of $13,900,000 with a rail system or $11,400,000 with a truck system. Transportation costs are estimated at $0.08/ton-mile for rail and $0.13/ton-mile for truck. 2 figs., 5 tabs

  6. Cementitious waste option scoping study report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, A.E.; Taylor, D.D.

    1998-02-01

    A Settlement Agreement between the Department of Energy (DOE) and the State of Idaho mandates that all high-level radioactive waste (HLW) now stored at the Idaho Chemical Processing Plant (ICPP) on the Idaho National Engineering and Environmental Laboratory (INEEL) will be treated so that it is ready to be moved out of Idaho for disposal by a target date of 2035. This study investigates the nonseparations Cementitious Waste Option (CWO) as a means to achieve this goal. Under this option all liquid sodium-bearing waste (SBW) and existing HLW calcine would be recalcined with sucrose, grouted, canisterized, and interim stored as a mixed-HLW for eventual preparation and shipment off-Site for disposal. The CWO waste would be transported to a Greater Confinement Disposal Facility (GCDF) located in the southwestern desert of the US on the Nevada Test Site (NTS). All transport preparation, shipment, and disposal facility activities are beyond the scope of this study. CWO waste processing, packaging, and interim storage would occur over a 5-year period between 2013 and 2017. Waste transport and disposal would occur during the same time period.

  7. 1964 Project Springfield studies. Research Report 2

    International Nuclear Information System (INIS)

    Feteris, P.J.

    1975-10-01

    The analysis of the data for a storm on April 4, 1964, showed that in spite of all efforts to obtain a dynamically and internally consistent three-dimensional analysis of conventional wind, pressure, and temperature data, there remain ambiguities of 50 to 100 miles in the horizontal location of the boundaries of the stratospheric air. Missing wind data and temperature errors, though not disastrous in routine meteorological analysis, can seriously affect the potential vorticity computations for several isentropic surfaces. Trajectory analyses introduce additional errors. Aircraft measurements of fallout beta activity, when carefully planned and made at map time, can improve the precision to 1000 feet in the vertical, and to a few miles in the horizontal. This precision is necessary for conclusive proof of the capture of radioactive particles from the stratosphere by precipitating clouds. However, for large-scale global studies of fallout transport, errors of 50 to 100 miles in the location of air parcels with certain potential. During the 1963 study, it was found that the flow patterns at different levels were seriously affected by coding and plotting errors in the radiosonde data which often escape attention in conventional upper air analyses

  8. Localization of functioning parathyroid adenomas by SPECT/CT. Report of two cases

    International Nuclear Information System (INIS)

    Pruzzo C, Rossana; Amaral P, Horacio; Rossi F, Ricardo; Morales K, Barbara; Martinez G, M.Eugenia

    2013-01-01

    Single photon emission computed tomography and computed tomography (SPECT/CT), integrates a gamma camera and a CT scan and is effective for the location of parathyroid adenomas. We report a 55 years old male and a 80 years old female with primary hyperparathyroidism. In both cases the 99m Tc-Sestamibi parathyroid scintigraphy detected a functioning nodule whose presence was confirmed with SPECT/CT

  9. Restoration of Function With Acupuncture Following Severe Traumatic Brain Injury: A Case Report

    OpenAIRE

    Wolf, Jacob; Sparks, Linda; Deng, Yong; Langland, Jeffrey

    2015-01-01

    This case report illustrates the improvement of an acupuncture-treated patient who incurred a severe traumatic brain injury (TBI) from a snowboarding accident. Over 4 years, the patient progressed from initially not being able to walk, having difficulty with speech, and suffering from poor eyesight to where he has now regained significant motor function, speech, and vision and has returned to snowboarding. A core acupuncture protocol plus specific points added to address the patient's ongoing...

  10. Rhetorics in Financial Reporting: An Interpretive Case Study

    Directory of Open Access Journals (Sweden)

    Anis Chariri

    2010-01-01

    Full Text Available This study is a case study conducted in an Indonesian insurance company. The aim of the study is to understand the dynamics of financial reporting in the company. Ontologically, this study is built on a belief that financial reporting practice is a socially constructed reality. As a socially constructed reality, such a practice involves an interaction among social actors, and between organisational actors and the institutional and cultural environment in which the company operates. The main research question of this study is why and how the company constructs its financial reporting to deliver messages to its audience. This study reveals that the company is committed to quality financial reporting because such reporting can be used to gain legitimacy and to maintain social harmony. Consequently, financial reporting is constructed as a rhetorical story about its performance, management ability and insight into the future.

  11. Autonomic nervous system function in patients with functional abdominal pain. An experimental study

    DEFF Research Database (Denmark)

    Jorgensen, L.S.; Christiansen, P.; Raundahl, U.

    1993-01-01

    Functional abdominal pain--that is, pain without demonstrable organic abnormalities--has often been associated with psychologic stress. The aim of the present study was to investigate whether sympathetic nervous system response to laboratory stress and basal parasympathetic neural activity were...... and serum cortisol did not increase at all in any of the groups. As a measure of parasympathetic neural activity, independent of sympathetic neural activity, the beat-to-beat variation of the heart rate was calculated. The functional patients had a significantly higher beat-to-beat variation expressed...... as the mean square successive differences of the R-R intervals (MSSD), indicating a higher basal parasympathetic neural activity (mean MSSD +/- SEM = 64 +/- 6 msec in the functional group, 46 +/- 6 msec in the healthy group, and 49 +/- 6 msec in the organic group; P = 0.03). A reduced sympathetic neural...

  12. Preliminary systems design study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Feizollahi, F.; Del Signore, J.C.

    1992-01-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each. This volume contains the descriptions and other relevant information of the four subsystems required for most of the ex situ processing systems. This volume covers the metal decontamination and sizing subsystem, soils processing subsystem, low-level waste subsystem, and retrieval subsystem

  13. Preliminary Systems Design Study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Quapp, W.J.; Feizollahi, F.; Del Signore, J.C.

    1991-07-01

    The System Design Study (SDS), part of the Waste Technology Development Department at Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic (TRU) waste stored at the Radioactive Waste Management Complex's (RWMC's) Subsurface Disposal Area (SDA) at INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. SDS resulted in the development of technology requirements including demonstration, testing and evaluation activities needed for implementing each concept. The SDS results are published in eight volumes. Volume 1 contains an executive summary. The SDS summary and analysis of results are presented in volume 2. Volumes 3 through 7 contain detailed descriptions of twelve system and four subsystem concepts. Volume 8 contains the appendices. 3 figs., 3 tabs

  14. Preliminary Systems Design Study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Quapp, W.J.; Feizollahi, F.; Del Signore, J.C.

    1991-07-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques available for the remediation of hazardous and transuranic waste stored at the Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept. The SDS results are published in eight volumes. Volume 1 contains an executive summary. The SDS summary and analysis of results are presented in Volume 2. Volumes 3 through 7 contain detailed descriptions of twelve system and four subsystem concepts. Volume 8 contains the appendixes. 23 refs., 23 figs., 16 tabs

  15. Studies in development immunogenetics. Annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Owen, R D

    1975-03-26

    This contract provides the research support for a group concerned with a relatively large range of problems. The integrating thread that runs through it is that of an interest in development and its genetic regulation, mainly in complex organisms and with an emphasis on the immune system as a model for developmental analysis and as a tool for following the development of other systems, especially the brain. It includes studies of biochemical genetics, primarily from a developmental viewpoint and with particular regard to defense mechanisms, and cellular aspects of the immune system. It extends into the area of cancer immunology and cell specificities as related to tumor systems, primarily from an immunogenetic viewpoint and with particular reference to leukemias in the mouse, and to disruptions of genetic control mechanisms in tumor development, especially as approached through the reappearance of fetal antigens associated with tumor development.

  16. Waste package performance allocation system study report

    International Nuclear Information System (INIS)

    Memory, R.D.

    1994-01-01

    The Waste Package Performance Allocation system study was performed in order to provide a technical basis for the selection of the waste package period of substantially complete containment and its resultant contribution to the overall total system performance. This study began with a reference case based on the current Mined Geologic Disposal System (MGDS) baseline design and added a number of alternative designs. The waste package designs were selected from the designs being considered in detail during Advanced Conceptual Design (ACD). The waste packages considered were multi-barrier packages with a 0.95 cm Alloy 825 inner barrier and a 10, 20, or 45 cm thick carbon steel outer barrier. The waste package capacities varied from 6 to 12 to 21 Pressurized Water Reactor (PWR) fuel assemblies. The vertical borehole and in-drift emplacement modes were also considered, as were thermal loadings of 25, 57, and 114 kW/acre. The repository cost analysis indicated that the 21 PWR in-drift emplacement mode option with the 10 cm and 20 cm outer barrier thicknesses are the least expensive and that the 12 PWR in-drift case has approximately the same cost as the 6 PWR vertical borehole. It was also found that the cost increase from the 10 cm outer barrier waste package to the 20 cm waste package was less per centimeter than the increase from the 20 cm outer barrier waste package to the 45 cm outer barrier waste package. However, the repository cost was nearly linear with the outer barrier thickness for the 21 PWR in-drift case. Finally, corrosion rate estimates are provided and the relationship of repository cost versus waste package lifetime is discussed as is cumulative radionuclide release from the waste package and to the accessible environment for time periods of 10,000 years and 100,000 years

  17. Radioactivity studies. Progress report. Volume I

    International Nuclear Information System (INIS)

    Cohen, N.

    1981-09-01

    A model was developed to be used to calculate the accumulation of uranium in the organs of the human body for different kinds of exposure. The proposed model divides the human body into compartments: red cell, short-term bone, long-term bone, kidney, and urine. The transfer rate between compartments is governed by 1st order kinetics. Transfer from plasma to the other compartments is instantaneous. Feedback from compartments to plasma is taken into account. The division of blood into plasma and red cell compartment is important to the calculations of uranium transport during the first few days after exposure. It was noted that uranium in bone has two different half-lives depending on the site of deposition, a short-term and a long-term bone component. An analytical solution to the model was proposed for any time-dependent exposure to uranium. This methodology is unique to this model and represents a significant change in analytical solutions. Specific analytical solutions for common cases of uranium exposure were derived. These include: single injection dose to the blood; exposure to background levels of natural uranium by ingestion; exposure through inhalation during working hours for uranium workers; single inhalation dose; constant inhalation exposure during a finite interval of time; and single ingestion dose. For model verification five baboons were injected intravenously with uranium nitrate and the partition of uranium between plasma and red cells was studied. The half-life in short-term bone was derived and the distribution in soft tissues four days after injection was studied: the kidney was the main organ for uranium deposition. The concentration in human skeleton was equal to 0.02 μg U/g ash. For this concentration in skeleton the gastrointestinal absorption factor was calculated as 23% and the daily excretion as 0.24 μg U/day

  18. Study on autonomous decentralized-cooperative function monitoring system

    International Nuclear Information System (INIS)

    Matsuoka, Takeshi; Numano, Masayoshi; Someya, Minoru; Fukuto, Junji; Mitomo, Nobuo; Miyazaki, Keiko; Matsukura, Hiroshi; Tanba, Yasuyuki

    1999-01-01

    In this study, a study further advanced on a base of results of study on artificial intelligence for nuclear power', one of nuclear basis crossover studies, conducted at five years planning from 1989 fiscal year was executed. Here was conducted on study on a system technology for supplying cooperation, judgement process, judgement results, and so forth between decentralized artificial intelligent elements (agents) to operation managers (supervisors) by focussing a system for monitoring if autonomous decentralized system containing plant operation and robot group action functioned appropriately. In 1997 fiscal year, by mainly conducting development for displaying working state of robot group, some investigations on integrated management of each function already development and maintained were executed. Furthermore, some periodical meetings on realization of its integration with operation control system and maintenance system with other research institutes were conducted. (G.K.)

  19. Preliminary modulation transfer function study on amorphous silicon

    International Nuclear Information System (INIS)

    Khairul Anuar Mohd Salleh; Ab Razak Hamzah; Mohd Ashhar Khalid

    2006-01-01

    Modulation Transfer Function, (MTF) is the scientific means of evaluating the fundamental spatial resolution performance of an imaging system. In the study, the modulation transfer function of an amorphous silicon (aSi) sensor array is measured by using Edge Spread Function (ESF) Technique which is extracting a profile from the linearised image of the sharp edge. The Platinum foil is used to determine the ESF. The detector under study was a 2,304 (h) x 3,200 (v) total pixel matrix, 127 μm2 pixel pitch, 57% fill factor and using Gd2O2S:Tb Kodak Lanex Regular as the conversion screen. The ESF measurement is done by using 75 - 100 kV range of x-ray with constant mA. (Author)

  20. Functionalized molecules studied by STM: motion, switching and reactivity

    International Nuclear Information System (INIS)

    Grill, Leonhard

    2008-01-01

    Functionalized molecules represent the central issue of molecular nanotechnology. Scanning tunnelling microscopy (STM) is a powerful method to investigate such molecules, because it allows us to image them with sub-molecular resolution when adsorbed on a surface and can be used at the same time as a tool to manipulate single molecules in a controlled way. Such studies permit deep insight into the conformational, mechanical and electronic structure and thus functionalities of the molecules. In this review, recent experiments on specially designed molecules, acting as model systems for molecular nanotechnology, are reviewed. The presented studies focus on key functionalities: lateral rolling and hopping motion on a supporting surface, the switching behaviour of azobenzene derivatives by using the STM tip and the controlled reactivity of molecular side groups, which enable the formation of covalently bound molecular nanoarchitectures. (topical review)

  1. A Longitudinal Study of Functional Outcomes in Patients with Limb Salvage Surgery for Soft Tissue Sarcoma

    Directory of Open Access Journals (Sweden)

    Eunsun Oh

    2018-01-01

    Full Text Available Background. Many studies have reported on the surgical outcomes of soft tissue sarcoma. However, there was no longitudinal cohort study. Because time is the most valuable factor for functional recovery, adjusting time value was the key for finding the causal relationship between other risk factors and postoperative function. Therefore, existing cross-sectional studies can neither fully explain the causal relationship between the risk factors and the functional score nor predict functional recovery. The aim of this study was to determine important predictive factors that affect postoperative functional outcomes and longitudinal changes in functional outcomes in patients who had undergone limb-sparing surgery (LSS for soft tissue sarcoma (STS. Methods. Between January 2008 and December 2014, we retrospectively enrolled 150 patients who had undergone LSS for STS and had been assessed for postoperative functional outcomes with questionnaires. To evaluate functional outcomes, we used the Musculoskeletal Tumor Society (MSTS score and Toronto Extremity Salvage Score (TESS. Multivariate generalized estimating equation (GEE analysis was used to identify the predictive factors, including size, stage, and anatomic location of tumor, bone resection, flap reconstruction, age, and time after surgery. Each continuous variable such as age and time after surgery was explored for statistically significant cutoff points using the Wilcoxon rank sum test. Results. Functional scores significantly improved until the second year after surgery and plateaued for the rest of the 5-year period. Age p<0.0001, bone resection p=0.0004, and time after surgery p<0.0001 were identified as significant predictive factors. The functional score was significantly higher in patients younger than 47 years old. Conclusions. Functional outcomes can improve until the second year after surgery. Patients who were older than 47 and underwent bone resection may have poor final functional

  2. Advances in study of molecular imaging reporte gene systems

    International Nuclear Information System (INIS)

    Wu Tao; An Rui

    2010-01-01

    The use of molecular imaging reporter gene systems has allowed gene therapy to move from the laboratory to the clinical application, which provides methodology to monitor the expression of therapeutic gene noninvasively and achieve quantitative outcome in vivo. Recently, the radionuclide reporter gene still is the focus many studies, but MRI and optical reporter gene have gradually played a important part in reporter gene systems. On the basis of combination of multi-subject, for example applied chemistry and molecular biology, more and more new modified reporter genes and molecular probes have spread out. This paper mainly introduces the advantages and disadvantages of reporter gene system and development trends. (authors)

  3. Parent-Reported Family Functioning Among Children With Cleft Lip/Palate.

    Science.gov (United States)

    Crerand, Canice E; Rosenberg, Janine; Magee, Leanne; Stein, Margot B; Wilson-Genderson, Maureen; Broder, Hillary L

    2015-11-01

    To examine family functioning related to sociodemographic and clinical characteristics in youth with cleft lip and/or palate (CL/P). Cross-sectional, multi-site investigation. Six U.S. cleft centers. A diverse sample of 1200 children with CL/P and their parents. Parents completed the Family Environment Scale (FES), which assesses three domains of family functioning: cohesion (or closeness), expressiveness (open expression of feelings), and conflict. Demographic and clinical characteristics were also assessed including race, ethnicity, type of insurance, and surgical recommendations. The FES scores for families seeking team evaluations for their youth with CL/P (mean age = 11.6 years) fall within the average range compared with normative samples. Families receiving surgical recommendations for their youth also had FES scores in the average range, yet families of children recommended for functional surgery reported greater cohesion, expressiveness, and less conflict compared with those recommended for aesthetic surgery (P conflict domain. Families with private insurance reported significantly greater cohesion (P functioning across domains was in the average range. However, observed differences by race, ethnicity, type of insurance, and surgical recommendation may warrant consideration in clinical management for patients and families.

  4. Multnomah County Hydrokinetic Feasibility Study: Final Feasibility Study Report

    Energy Technology Data Exchange (ETDEWEB)

    Spain, Stephen

    2012-03-15

    developers and scientists a location to temporarily deploy and test hydrokinetic devices, and also function as an educational tool for the general public. Bridge piers provide an excellent pre-existing anchor point for hydrokinetic devices, and existing infrastructure at the Morrison and Broadway Bridges may reduce installation costs. Opportunity exists to partner with local universities with engineering and environmental interest in renewable energy. A partnership with Portland State University's engineering school could provide students with an opportunity to learn about hydrokinetics through senior design projects. Oregon State University and University of Washington, which are partnered through the Northwest National Marine Renewable Energy Center (NNMREC) to study and test hydrokinetic technology, are also relatively local to the site. In addition to providing an opportunity for both public and private entities to learn technically about in-stream kinetics, this approach will encourage grant funding for outreach, education, and product development, while also serving as a positive community relations opportunity for the County and its partners.

  5. Adsorption isotherm special study. Final report

    International Nuclear Information System (INIS)

    1993-05-01

    The study was designed to identify methods to determine adsorption applicable to Uranium Mill Tailings Remedial Action (UMTRA) Project sites, and to determine how changes in aquifer conditions affect metal adsorption, resulting retardation factors, and estimated contaminant migration rates. EPA and ASTM procedures were used to estimate sediment sorption of U, As, and Mo under varying groundwater geochemical conditions. Aquifer matrix materials from three distinct locations at the DOE UMTRA Project site in Rifle, CO, were used as the adsorbents under different pH conditions; these conditions stimulated geochemical environments under the tailings, near the tailings, and downgradient from the tailings. Grain size, total surface area, bulk and clay mineralogy, and petrography of the sediments were characterized. U and Mo yielded linear isotherms, while As had nonlinear ones. U and Mo were adsorbed strongly on sediments acidified to levels similar to tailings leachate. Changes in pH had much less effect on As adsorption. Mo was adsorbed very little at pH 7-7.3, U was weakly sorbed, and As was moderately sorbed. Velocities were estimated for metal transport at different pHs. Results show that the aquifer materials must be characterized to estimate metal transport velocities in aquifers and to develop groundwater restoration strategies for the UMTRA project

  6. Hot isostatic press waste option study report

    International Nuclear Information System (INIS)

    Russell, N.E.; Taylor, D.D.

    1998-02-01

    A Settlement Agreement between the Department of Energy and the State of Idaho mandates that all high-level radioactive waste now stored at the Idaho Chemical Processing Plant be treated so that it is ready to move out of Idaho for disposal by the target date of 2035. This study investigates the immobilization of all Idaho Chemical Processing Plant calcine, including calcined sodium bearing waste, via the process known as hot isostatic press, which produces compact solid waste forms by means of high temperature and pressure (1,050 C and 20,000 psi), as the treatment method for complying with the settlement agreement. The final waste product would be contained in stainless-steel canisters, the same type used at the Savannah River Site for vitrified waste, and stored at the Idaho National Engineering and Environmental Laboratory until a national geological repository becomes available for its disposal. The waste processing period is from 2013 through 2032, and disposal at the High Level Waste repository will probably begin sometime after 2065

  7. Willamette oxygen supplementation studies. Annual progress report

    International Nuclear Information System (INIS)

    Ewing, R.D.; Ewing, S.K.; Sheahan, J.E.

    1994-09-01

    Hydropower development and operations in the Columbia River basin have caused the loss of 5 million to 11 million salmonids. An interim goal of the Northwest Power Planning Council is to reestablish these historical numbers by doubling the present runs from 2.5 million adult fish to 5.0 million adult fish. This increase in production will be accomplished through comprehensive management of both wild and hatchery fish, but artificial propagation will play a major role in the augmentation process. The current husbandry techniques in existing hatcheries require improvements that may include changes in rearing densities, addition of oxygen, removal of excess nitrogen, and improvement in raceway design. Emphasis will be placed on the ability to increase the number of fish released from hatcheries that survive to return as adults. Rearing density is one of the most important elements in fish culture. Fish culturists have attempted to rear fish in hatchery ponds at densities that most efficiently use the rearing space available. Such efficiency studies require a knowledge of cost of rearing and the return of adults to the fisheries and to the hatchery

  8. LHC Report: studies for the future

    CERN Multimedia

    Jan Uythoven & Rogelio Tomás García for the LHC team

    2015-01-01

    The proton run finished in the morning of Wednesday, 4 November and was followed by five days of Machine Development period, just before the start of the Technical Stop on Monday, 9 November. A lot of lessons have been learned and this opens the way to providing higher luminosity to the experiments.    During this year’s third and final Machine Development period, the different teams working on the machine were able to deepen their understanding of beam control and beam dynamics. The careful study of beam instabilities revealed a major improvement during the year. This time, stabilising the beams in the LHC required much weaker octupole magnet stabilisation than during the previous Machine Development period. This was due to the very effective electron cloud scrubbing that took place during physics fills after the summer holidays. This opens the road towards having more bunches in the machine, higher bunch charge and thus higher luminosity. To obtain hig...

  9. Direct cementitious waste option study report

    International Nuclear Information System (INIS)

    Dafoe, R.E.; Losinski, S.J.

    1998-02-01

    A settlement agreement between the Department of Energy (DOE) and the State of Idaho mandates that all high-level radioactive waste (HLW) now stored at the Idaho Chemical Processing Plant (ICPP) will be treated so that it is ready to be moved out of Idaho for disposal by a target data of 2035. This study investigates the direct grouting of all ICPP calcine (including the HLW dry calcine and those resulting from calcining sodium-bearing liquid waste currently residing in the ICPP storage tanks) as the treatment method to comply with the settlement agreement. This method involves grouting the calcined waste and casting the resulting hydroceramic grout into stainless steel canisters. These canisters will be stored at the Idaho National Engineering and Environmental Laboratory (INEEL) until they are sent to a national geologic repository. The operating period for grouting treatment will be from 2013 through 2032, and all the HLW will be treated and in interim storage by the end of 2032

  10. Hot isostatic press waste option study report

    Energy Technology Data Exchange (ETDEWEB)

    Russell, N.E.; Taylor, D.D.

    1998-02-01

    A Settlement Agreement between the Department of Energy and the State of Idaho mandates that all high-level radioactive waste now stored at the Idaho Chemical Processing Plant be treated so that it is ready to move out of Idaho for disposal by the target date of 2035. This study investigates the immobilization of all Idaho Chemical Processing Plant calcine, including calcined sodium bearing waste, via the process known as hot isostatic press, which produces compact solid waste forms by means of high temperature and pressure (1,050 C and 20,000 psi), as the treatment method for complying with the settlement agreement. The final waste product would be contained in stainless-steel canisters, the same type used at the Savannah River Site for vitrified waste, and stored at the Idaho National Engineering and Environmental Laboratory until a national geological repository becomes available for its disposal. The waste processing period is from 2013 through 2032, and disposal at the High Level Waste repository will probably begin sometime after 2065.

  11. Direct cementitious waste option study report

    Energy Technology Data Exchange (ETDEWEB)

    Dafoe, R.E.; Losinski, S.J.

    1998-02-01

    A settlement agreement between the Department of Energy (DOE) and the State of Idaho mandates that all high-level radioactive waste (HLW) now stored at the Idaho Chemical Processing Plant (ICPP) will be treated so that it is ready to be moved out of Idaho for disposal by a target data of 2035. This study investigates the direct grouting of all ICPP calcine (including the HLW dry calcine and those resulting from calcining sodium-bearing liquid waste currently residing in the ICPP storage tanks) as the treatment method to comply with the settlement agreement. This method involves grouting the calcined waste and casting the resulting hydroceramic grout into stainless steel canisters. These canisters will be stored at the Idaho National Engineering and Environmental Laboratory (INEEL) until they are sent to a national geologic repository. The operating period for grouting treatment will be from 2013 through 2032, and all the HLW will be treated and in interim storage by the end of 2032.

  12. Environmental and Social Impact Study: Final Report

    International Nuclear Information System (INIS)

    2011-04-01

    The tsetse control project (commonly known as tsetse flies) is an initiative of the Directorate of Livestock (project coordinating institution) and the ISRA (Senegalese Agricultural Research Institute) Accompaniment and diagnosis of the project. It is part of the cooperation between Senegal and the International Atomic Energy Agency (IAEA).The method of control that will be applied is the technique of sterile males.This technique of sterile males, however, is coupled with the use of deltamethrin (D6), a neurotoxic chemical (in adult insects) that is fast and fairly rapidly biodegradable in the environment.This study is carried out with the aim of taking good account of the environmental impacts of the various activities envisaged by the project. Its objective is to assess the biophysical, social and economic impacts of the project and to propose measures to mitigate or compensate for negative impacts and to reinforce positive impacts within the framework of an Environmental Management Plan and (ESMP). It also presents an environmental and social monitoring and monitoring plan to assess the effectiveness of the proposed mitigation measures.

  13. Pinellas Plant feasibility study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-09-01

    The Pinellas Plant was built in 1956 to manufacture neutron generators, a principal component in nuclear weapons. In September 1990, the Department of Health and Rehabilitative Services (HRS) entered into an agreement with DOE to independently examine environmental monitoring data from the plant and health data from Pinellas County to determine if an epidemiological study is technically feasible to measure possible off-site health effects from ionizing radiation. Through normal plant operations, some radioactive materials have been released to the environment. Eighty percent of the total plant releases of 107,707 curies occurred in the early years of plant operation (1957--1960). The primary materials released were tritium gas, tritium oxide and krypton-85. Environmental monitoring for radioactive releases from the plant has been done regularly since 1975. The US Public Health Service Centers for Disease Control and Prevention (CDC), in assisting HRS, has determined that sufficient radiological data exist by which a dose reconstruction can be done. A dose reconstruction can provide an estimate of how much radiological exposure someone living in the vicinity of the Pinellas Plant may have suffered from environmental releases.

  14. Willamette Oxygen Supplementation Studies : Annual Report 1994.

    Energy Technology Data Exchange (ETDEWEB)

    Ewing, R.D.; Ewing, S.K.; Sheahan, J.E.

    1994-09-01

    Hydropower development and operations in the Columbia River basin have caused the loss of 5 million to 11 million salmonids. An interim goal of the Northwest Power Planning Council is to reestablish these historical numbers by doubling the present runs from 2.5 million adult fish to 5.0 million adult fish. This increase in production will be accomplished through comprehensive management of both wild and hatchery fish, but artificial propagation will play a major role in the augmentation process. The current husbandry techniques in existing hatcheries require improvements that may include changes in rearing densities, addition of oxygen, removal of excess nitrogen, and improvement in raceway design. Emphasis will be placed on the ability to increase the number of fish released from hatcheries that survive to return as adults. Rearing density is one of the most important elements in fish culture. Fish culturists have attempted to rear fish in hatchery ponds at densities that most efficiently use the rearing space available. Such efficiency studies require a knowledge of cost of rearing and the return of adults to the fisheries and to the hatchery.

  15. Preliminary Systems Design Study assessment report

    International Nuclear Information System (INIS)

    Mayberry, J.L.; Feizollahi, F.; Del Signore, J.C.

    1992-01-01

    The System Design Study (SDS), part of the Waste Technology Development Department at the Idaho National Engineering Laboratory (INEL), examined techniques for the remediation of hazardous and transuranic waste stored at Radioactive Waste Management Complex's Subsurface Disposal Area at the INEL. Using specific technologies, system concepts for treating the buried waste and the surrounding contaminated soil were evaluated. Evaluation included implementability, effectiveness, and cost. The SDS resulted in the development of technology requirements including demonstration, testing, and evaluation activities needed for implementing each concept. This volume contains introduction section containing a brief SDS background and lists the general assumptions and considerations used during the development of the system concepts. The introduction section is followed by sections describing two system concepts that produce a waste form in compliance with the Waste Isolation Pilot Plant (WIPP) Waste Acceptance Criteria (WAC) and transportation package (TRAMPAC) requirements. This system concept category is referred to as Waste Form 4, ''WIPP and TRAMPAC Acceptable.'' The following two system concepts are under this category: Sort, Treat, and Repackage System (4-BE-2); Volume Reduction and Packaging System (4-BE-4)

  16. OTEC LSCT study, additional work. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1980-12-01

    In the final stage of the Large Systems Construction Techniques (LSCT) study, work on the elastomer cold water pipe and on the design of power modules for the Sparmod platform concept was performed. Six different configurations of pipe are compared, and the pressure difference between the outside and inside of the pipe is analyzed. Static forces in the membrane are also discussed. Calculation of the strength and stability of concrete rings are done. The forces, membrane materials and connection details of the elastomer membrane of the pipe are discussed. Construction and handling of the pipe and rings are discussed, and a rough breakdown of the costs for a 30 m diameter pipe is given. The consequences of the sparmod principles to the OTEC-plant design are investigated. Conceptual design of a 50 MW power module for the 400 MW sparmod design was done, followed by a construction and installation plan. Conceptual design of a 50 MW and 100 MW Plant based on the sparmod principle is done to investigate the influence of scale. (LEW)

  17. Technical study gas storage. Final report

    International Nuclear Information System (INIS)

    Borowka, J.; Moeller, A.; Zander, W.; Koischwitz, M.A.

    2001-01-01

    This study will answer the following questions: (a) For what uses was the storage facility designed and for what use is it currently applied? Provide an overview of the technical data per gas storage facility: for instance, what is its capacity, volume, start-up time, etc.; (b) How often has this facility been used during the past 10 years? With what purpose was the facility brought into operation at the time? How much gas was supplied at the time from the storage facility?; (c) Given the characteristics and the use of the storage facility during the past 10 years and projected gas consumption in the future, how will the storage facility be used in the future?; (d) Are there other uses for which the gas storage facility can be deployed, or can a single facility be deployed for numerous uses? What are the technical possibilities in such cases? Questions (a) and (b) are answered separately for every storage facility. Questions (c) and (d) in a single chapter each (Chapter 2 and 3). An overview of the relevant storage data relating to current use, use in the last 10 years and use in future is given in the Annex

  18. New Particle Formation Study Final Campaign Report

    Energy Technology Data Exchange (ETDEWEB)

    Smith, JN; McMurry, PH [University of Minnesota

    2015-01-01

    The scientific foci of the New Particle Formation Study were the formation and evolution of atmospheric aerosols and the impacts of newly formed particles on cloud processes. Specifically, we planned to: (1) to identify the species and mechanisms responsible for the initial steps of new particle formation, i.e., the formation of thermodynamically stable clusters; (2) investigate the role of acid-base chemistry in new particle growth through measurements of ammonia and amines as well as organic and inorganic acids in both atmospheric nanoparticles and the gas phase; (3) investigate the contribution of other surface area or volume-controlled processes to nanoparticle formation and growth; (4) create a comprehensive dataset related to new particle formation and growth that can be used as input for our own thermodynamic models as well as the modeling efforts by our Department of Energy (DOE) Aerosol Life Cycle working group collaborators; (5) characterize the increase of the number and activity of cloud condensation nuclei (CCN) due to particle formation and growth; (6) determine the regional extent of new particle formation to address the role that atmospheric transport plays in determining the impacts, if any, of new particle formation on cloud number and properties.

  19. Nuclear safety code study. Final report

    International Nuclear Information System (INIS)

    Jackson, C.; Abumansoor, K.; Myers, E.; Jesperson, D.; Cramer, E.; O'Reilly, B.; Carmichael, B.

    1980-06-01

    An unprotected overpower accident in a Liquid Metal Fast Breeder Reactor is studied. We construct a mathematical model and derive a system of partial differential equations for the temperature. After spatial discretization, we have a large system of ordinary differential equations; the system is stiff. We solve the steady state version of our equations analytically and obtain good agreement with other work. Then we solve the time-dependent problem numerically, using two stiff techniques and one non-stiff technique. The stiff techniques are vastly more efficient than the non-stiff technique. Between the two stiff techniques, the Gear backward differentiation formulas are more efficient than an implicit Runge-Kutta type method. We also compare the use of the full neutron kinetics equations to an approximation called the zero-lifetime system. Use of the zero-lifetime system is thought to make the problem easier to solve. Results indicate this is not true when a good stiff method is used. Thus use of the zero-lifetime system is probably not necessary, and should be avoided

  20. Pinellas Plant feasibility study. Final report

    International Nuclear Information System (INIS)

    1994-09-01

    The Pinellas Plant was built in 1956 to manufacture neutron generators, a principal component in nuclear weapons. In September 1990, the Department of Health and Rehabilitative Services (HRS) entered into an agreement with DOE to independently examine environmental monitoring data from the plant and health data from Pinellas County to determine if an epidemiological study is technically feasible to measure possible off-site health effects from ionizing radiation. Through normal plant operations, some radioactive materials have been released to the environment. Eighty percent of the total plant releases of 107,707 curies occurred in the early years of plant operation (1957--1960). The primary materials released were tritium gas, tritium oxide and krypton-85. Environmental monitoring for radioactive releases from the plant has been done regularly since 1975. The US Public Health Service Centers for Disease Control and Prevention (CDC), in assisting HRS, has determined that sufficient radiological data exist by which a dose reconstruction can be done. A dose reconstruction can provide an estimate of how much radiological exposure someone living in the vicinity of the Pinellas Plant may have suffered from environmental releases

  1. Uranium miner lung cancer study. Final report

    International Nuclear Information System (INIS)

    Saccomanno, G.

    1986-06-01

    This study on uranium miners was started in 1957 and extended through June 30, 1986. It consisted of the routine screening of sputum from uranium miners of the Colorado Plateau, and collection of surgical and autopsy material from uranium miners who developed lung cancer. The projects resulted in: (1) Proof, for the first time, that cancer takes from 10 to 15 years to develop from the maximum accumulated carcinogenic insult and can be demonstrated through progressive cellular changes of the bronchial tree; (2) Development of a method for preserving, concentrating, and processing sputum samples. This is known as the Saccomanno Technique, and is used worldwide in diagnosing lung cancer; (3) Publication of the 1st and 2nd editions of a full-color textbook entitled ''Diagnostic Pulmonary Cytology;'' (4) Presentation of conclusive data on the effects of cigarette smoking and alpha progeny radiation on uranium miners, and information on safe radiation exposure levels; (5) Development of a brush-wash tube for collecting, concentrating, and preparing bronchial brushings and washings; (6) Development of cytological criteria which has improved sensitivity from 30% to about 60%; (7) Development of criteria for cytologic identification of carcinoma in situ, making it possible to diagnose lung cancer before it can be detected on chest x-ray

  2. Imaging tools to study pharmacology: functional MRI on small rodents

    Directory of Open Access Journals (Sweden)

    Elisabeth eJonckers

    2015-10-01

    Full Text Available Functional Magnetic Resonance Imaging (fMRI is an excellent tool to study the effect of pharmacological modulations on brain function in a non-invasive and longitudinal manner. We introduce several blood oxygenation level dependent (BOLD fMRI techniques, including resting state (rsfMRI, stimulus-evoked (st-fMRI, and pharmacological MRI (phMRI. Respectively, these techniques permit the assessment of functional connectivity during rest as well as brain activation triggered by sensory stimulation and/or a pharmacological challenge. The first part of this review describes the physiological basis of BOLD fMRI and the hemodynamic response on which the MRI contrast is based. Specific emphasis goes to possible effects of anaesthesia and the animal’s physiological conditions on neural activity and the hemodynamic response. The second part of this review describes applications of the aforementioned techniques in pharmacologically-induced, as well as in traumatic and transgenic disease models and illustrates how multiple fMRI methods can be applied successfully to evaluate different aspects of a specific disorder. For example, fMRI techniques can be used to pinpoint the neural substrate of a disease beyond previously defined hypothesis-driven regions-of-interest (ROIs. In addition, fMRI techniques allow one to dissect how specific modifications (e.g. treatment, lesion etc. modulate the functioning of specific brain areas (st-fMRI, phMRI and how functional connectivity (rsfMRI between several brain regions is affected, both in acute and extended time frames. Furthermore, fMRI techniques can be used to assess/explore the efficacy of novel treatments in depth, both in fundamental research as well as in preclinical settings. In conclusion, by describing several exemplary studies, we aim to highlight the advantages of functional MRI in exploring the acute and long-term effects of pharmacological substances and/or pathology on brain functioning along with

  3. Quality of Life of High-Functioning Children and Youth with Autism Spectrum Disorder and Typically Developing Peers: Self- and Proxy-Reports

    Science.gov (United States)

    Egilson, Snaefrídur T.; Ólafsdóttir, Linda B.; Leósdóttir, Thóra; Saemundsen, Evald

    2017-01-01

    Studies have shown parents to report lower quality of life for their children with autism spectrum disorder than children's self-report scores and the same applies for data on typically developing children. Our objectives were to: (1) explore how high-functioning children with autism spectrum disorder rate their quality of life compared with…

  4. Radioactivity studies. Progress report. Volume II

    International Nuclear Information System (INIS)

    Cohen, N.

    1981-09-01

    The metabolism of 243 244 Cm in nine adult female baboons following intravenous injection was studied. Curium-243,244 was administered as a single injection of curium citrate in dosages of 0.053 to 0.220 μCi/kg. The behavior of 243 244 Cm at these low dosages was quantitated by external whole-body and partial-body counting, bioassay of blood, urine and feces samples, liver biopsies, and post-mortem tissues analysis. Curium-243,244 rapidly passed from the blood to other tissues. At 1 and 24 h after injection, the amounts circulating were 10% and 1%, respectively. At 24 h after injection 70% of the 243 244 Cm was located within soft tissues, probably associated with extracellular fluid; the liver alone contained 32% of the injected activity. During the first weeks the content of 243 244 Cm in soft tissues decreased sharply. As time progressed, significant deposition was noted in the liver and the skeleton. Approximately 20% of the injected activity was in the liver at 1 month with a 40 day half-time. The skeleton reached a maximum burden of 57% by 100 days; the half-time observed in bone was 4 to 16 y. During the first 24 h, 10% of the injected activity appeared in the urine decreasing to 0.1%/day at 30 days and 0.01%/day at 200 days. Fecal excretion increased reaching a maximum level at four weeks. The amount of 243 244 Cm excreted in the feces during the initial 4 to 5 months (approx. 20%) and the rate of elimination in the feces after the first month paralleled the retention in the liver indicating an hepatic-biliary-fecal pathway. A model illustrating the interaction of seven internal compartments with respect to the translocation kinetics of 243 244 Cm was derived based upon this data. Solutions of the model were derived for two specific time-related exposures

  5. Final report for NIF chamber dynamics studies

    International Nuclear Information System (INIS)

    Burnham, A; Peterson, P F; Scott, J M

    1998-01-01

    The National Ignition Facility (NIF), a 1.8 MJ, 192 laser beam facility, will have anticipated fusion yields of up to 20 MJ from D-T pellets encased in a gold hohlraum target. The energy emitted from the target in the form of x rays, neutrons, target debris kinetic energy, and target shrapnel will be contained in a 5 m. radius spherical target chamber. various diagnostics will be stationed around the target at varying distances from the target. During each shot, the target will emit x rays that will vaporize nearby target facing surfaces including those of the diagnostics, the target positioner, and other chamber structures. This ablated vapor will be transported throughout the chamber, and will eventually condense and deposit on surfaces in the chamber, including the final optics debris shields. The research at the University of California at Berkeley relates primarily to the NIF chamber dynamics. The key design issues are the ablation of the chamber structures, transport of the vapor through the chamber and the condensation or deposition processes of those vaporized materials. An understanding of these processes is essential in developing a concept for protecting the fina optics debris shields from an excessive coating (> 10 A) of target debris and ablated material, thereby prolonging their lifetime between change-outs. At Berkeley, we have studied the physical issues of the ablation process and the effects of varying materials, the condensation process of the vaporized material, and design schemes that can lower the threat posed to the debris shields by these processes. The work or portions of the work completed this year have been published in several papers and a dissertation [l-5

  6. Individual renal function study using dynamic computed tomography

    International Nuclear Information System (INIS)

    Fukuda, Yutaka; Kiya, Keiichi; Suzuki, Yoshiharu

    1990-01-01

    Dynamic CT scans of individual kindneys were obtained after an intravenous bolus injection of contrast agent. Time-density curves measured from the renal cortex, medulla and pelvis revealed the changes in density produced by the contrast agent reflecting the differential phase of renal function. Renal cortical density increased rapidly after bolus administration and then renal medullary and pelvic density increased continuously. In analyzing time-density curve, the cortico-medullary junction time, which is the time when the cortical and medullary curves cross was 57±8 seconds in patients with normal renal function. The cortico-medullary junction time was delayed in patient with decreased glomerular filtration rate. The cortico-pelvic junction time, which is the time when the cortical and pelvic curves cross was 104±33 seconds in patients with normal renal function. The cortico-pelvic junction time was delayed in patients with declined urinary concentrating capacity. In patients with unilateral renal agenesis and patients who were treated surgically by ureteral sprits, the relationship between individual renal functions and these junction times was examined. As a result of study there were inversely significant correlations between C-M junction time and unilateral GFR and between C-P junction time and urinary concentrating capacity. These studies indicate that dynamic CT scanning is an effective way that individual renal function can be monitored and evaluated. (author)

  7. Study of Thyroid Function in Children with Attention Deficit ...

    African Journals Online (AJOL)

    Study of Thyroid Function in Children with Attention Deficit Hyperactivity Disorder and Aggressive Behavior. ... Results: There was a significantly lower IQ (p<0.05) among patients (84.2±16.4%) when compared to controls (100.9±5.4%).

  8. Metabolomics to study functional consequences in peroxisomal disorders

    NARCIS (Netherlands)

    Herzog, K.

    2017-01-01

    This thesis focusses on metabolomics approaches performed in cultured cells and blood samples from patients with peroxisomal disorders. By applying both targeted and untargeted metabolomics, the aim of these approaches was to study the functional consequences of the primary genetic defects causing

  9. Studies on the proximate composition, functional properties and ...

    African Journals Online (AJOL)

    The present study produced full fat and defatted flours from matured ackee apple arils and evaluated the proximate composition and the effect of pH and salt concentrations on some of the functional properties of the full fat flour and the defatted flour. Matured ackee apple arils were oven-dried at 60 oC and milled to obtain ...

  10. Sexual functioning of people with rheumatoid arthritis: a multicenter study

    NARCIS (Netherlands)

    van Berlo, Willy T.M.; van de Wiel, Harry B.M.; Taal, Erik; Rasker, Johannes J.; Weijmar Schultz, Willibrord C.M.; van Rijswijk, Martin H.

    2007-01-01

    The objective of this study is to compare men and women with rheumatoid arthritis (RA) to controls regarding sexual motivation, activity, satisfaction, and specific sexual problems, and to determine the correlation of physical aspects of the disease with sexual functioning. Questionnaire for

  11. Sexual functioning of people with rheumatoid arthritis : a multicenter study

    NARCIS (Netherlands)

    van Berlo, W.T.M.; van de Wiel, H.B.M.; Taal, E.; Rasker, J.J.; Schultz, W.C.M.W.; van Rijswijk, M.H.

    The objective of this study is to compare men and women with rheumatoid arthritis (RA) to controls regarding sexual motivation, activity, satisfaction, and specific sexual problems, and to determine the correlation of physical aspects of the disease with sexual functioning. Questionnaire for

  12. Sexual abuse predicts functional somatic symptoms : An adolescent population study

    NARCIS (Netherlands)

    Bonvanie, Irma J.; van Gils, Anne; Janssens, Karin A. M.; Rosmalen, Judith G. M.

    The main aim of this study was to investigate the effect of childhood sexual abuse on medically not well explained or functional somatic symptoms (FSSs) in adolescents. We hypothesized that sexual abuse predicts higher levels of FSSs and that anxiety and depression contribute to this relationship.

  13. Executive function training in children with SLI: A pilot study

    NARCIS (Netherlands)

    Vugs, B.A.M.; Knoors, H.E.T.; Cuperus, J.M.; Hendriks, M.P.H.; Verhoeven, L.T.W.

    2017-01-01

    The aim of this study was to evaluate the effectiveness of a computer-based executive function (EF) training in children with specific language impairment (SLI). Ten children with SLI, ages 8 to 12 years, completed a 25-session training of visuospatial working memory, inhibition and cognitive

  14. Study of liver function and expression of some detoxification genes ...

    African Journals Online (AJOL)

    Ahmad Ali Badr

    2015-10-19

    Oct 19, 2015 ... In this study we investigate the effect(s) of MTBE on liver function indices and ... Methyl-tertiary butyl ether (MTBE), a well known gasoline oxygenate, is added to ..... ether (MTBE) in CD-1 mice and F-344 rats. J Appl Toxicol.

  15. Moessbauer studies of superparamagnetic ferrite nanoparticles for functional application

    Energy Technology Data Exchange (ETDEWEB)

    Mazeika, K., E-mail: kestas@ar.fi.lt; Jagminas, A.; Kurtinaitiene, M. [SSRI Center for Physical Sciences and Technology (Lithuania)

    2013-04-15

    Nanoparticles of CoFe{sub 2}O{sub 4} and MnFe{sub 2}O{sub 4} prepared for functional applications in nanomedicine were studied using Moessbauer spectrometry. Superparamagnetic properties of nanoparticles of different size and composition were compared applying collective excitations and multilevel models for the description of the Moessbauer spectra.

  16. Tomo-synthesis. Bibliographic study report

    International Nuclear Information System (INIS)

    2016-01-01

    Tomo-synthesis is a recent technique for breast imaging. This technique, qualified as 'pseudo-3D', draws the attention of health professionals. Indeed, this technique could offer a gain in sensibility and in specificity in the detection of breast cancers compared to 2D mammography, thanks to the reduction of the tissues' overlapping in particular. Although its place and its clinical indication are not still clearly defined, tomo-synthesis is already used in France. The introduction of this technique within the national breast cancer screening program, seems to be foreseen by the authorities in the coming years. IRSN, in the scope of its mission of evaluation of the dose impact of innovative techniques, is closely interested in this technique and has proceeded in 2015 to a bibliographical review of the state of the art in tomo-synthesis. This review paid specific attention to the following points: conception of the installations, dose, image quality and quality control. it has highlighted several points of attention, which incite IRSN to formulate certain recommendations to accompany the spreading of this new technique in France. Most of the clinical trials validating the use of tomo-synthesis were realized on systems of a single manufacturer. However, manufacturers' strategies of design are heterogeneous. There is no unique technique of tomo-synthesis but several, of which equivalence in terms of technical and clinical performances is not demonstrated. Due to the heterogeneity of the different models available on the French market, IRSN recommends not to extrapolate the results of clinical studies obtained on a specific system but to consolidate them for all the available systems. In many imaging departments, tomo-synthesis is already implemented in addition or in substitution of 2D mammography without any regulatory quality control and periodic technical checks. The European reference standard for quality control of these devices is not yet

  17. Frequency of Different Psychiatric Disorders in Patients With Functional Bowel Disorders: A Short Report

    Directory of Open Access Journals (Sweden)

    Fakhraei

    2015-06-01

    Full Text Available Background Functional gastrointestinal (GI disorders are very common and many patients with such disorders are not satisfied with treatment outcomes. Psychological aspects of functional disorders need special attention that may play an important role in patient management. Objectives In this study, psychology evaluation was performed for a population of patients with functional bowel disorders. Patients and Methods One hundred patients with functional bowel disorders including 50 patients with irritable bowel syndrome (IBS referred to GI clinics were candidates for psychiatry evaluation; of those 60 patients completed the study. Psychiatric disorders were diagnosed using a structured clinical interview based on diagnostic and statistical manual of mental disorders IV (DSM IV. Results Of 60 patients with functional bowel disorders (including 39 IBS, 51 (85% were diagnosed with at least one psychiatry disorder. The most common disorders were dysthymia (25% and obsessive-compulsive disorder (20%. There was no significant difference between IBS patients and other functional bowel disorders regarding the prevalence of psychiatric disorders. Conclusions Psychiatric disorders are very prevalent among patients with functional bowel disorders. Prompt diagnosis and appropriate management of associated psychiatric disorders along with GI targeted treatments may lead to a better outcome in these patients.

  18. Satellite Search and Rescue System Studies: Alarm and Position Reporting.

    Science.gov (United States)

    alarm and position reporting ( ALPR ) techniques, and the operational or planned spacecraft which might be available for piggybacking the ALPR payload...Several system concepts were then developed to perform the ALPR functions. The candidates were screened and the preferred system concepts were chosen

  19. The prevalence and correlates of low sexual functioning in women on hemodialysis: A multinational, cross-sectional study.

    Directory of Open Access Journals (Sweden)

    Valeria Saglimbene

    Full Text Available Sexual dysfunction may affect 80% of women in hemodialysis. However the specific patterns and clinical correlates of sexual functioning remain poorly described. The aim of this study was to assess prevalence and correlates of the individual domains of sexual functioning in women treated with hemodialysis. We recruited, into this multinational cross-sectional study, women treated with long-term hemodialysis (Collaborative Working Group on Depression and Sexual dysfunction in Hemodialysis study. Self-reported domains of sexual functioning were assessed by the Female Sexual Function Index, which is routinely administered within the network of dialysis patients followed by the working group. Lower scores represented lower sexual functioning. Socio-demographic and clinical correlates of each domain of sexual functioning were identified by stepwise multivariable linear regression. Sensitivity analyses were restricted to women who reported being sexually active. We found that of 1309 enrolled women, 659 (50.3% provided complete responses to FSFI survey questions and 232 (35% reported being sexually active. Overall, most respondents reported either no sexual activity or low sexual functioning in all measured domains (orgasm 75.1%; arousal 64.0%; lubrication 63.3%; pain 60.7%; satisfaction 60.1%; sexual desire 58.0%. Respondents who were waitlisted for a kidney transplant reported scores with higher sexual functioning, while older respondents reported scores with lower functioning. The presence of depression was associated with worse lubrication and pain scores [mean difference for depressed versus non-depressed women (95% CI -0.42 (-0.73 to -0.11, -0.53 (-0.89 to -0.16, respectively] while women who had experienced a previous cardiovascular event reported higher pain scores [-0.77 (-1.40- to -0.13]. In conclusion, women in hemodialysis reported scores consistent with marked low sexual functioning across a range of domains; the low functioning appeared

  20. Nuclear magnetic resonance studies of epithelial metabolism and function

    International Nuclear Information System (INIS)

    Balaban, R.S.

    1982-01-01

    Nuclear magnetic resonance (NMR) is a noninvasive technique for studying cellular metabolism and function. In this review the general applications and advantages of NMR will be discussed with specific reference to epithelial tissues. Phosphorus NMR investigations have been performed on epithelial tissues in vivo and in vitro; however, other detectable nuclei have not been utilized to date. Several new applications of phosphorus NMR to epithelial tissues are also discussed, including studies on isolated renal tubules and sheet epithelia

  1. Kinetic-energy functionals studied by surface calculations

    DEFF Research Database (Denmark)

    Vitos, Levente; Skriver, Hans Lomholt; Kollár, J.

    1998-01-01

    The self-consistent jellium model of metal surfaces is used to study the accuracy of a number of semilocal kinetic-energy functionals for independent particles. It is shown that the poor accuracy exhibited by the gradient expansion approximation and most of the semiempirical functionals in the lo...... density, high gradient limit may be subtantially improved by including locally a von Weizsacker term. Based on this, we propose a simple one-parameter Pade's approximation, which reproduces the exact Kohn-Sham surface kinetic energy over the entire range of metallic densities....

  2. The functionalities of mobile applications : case study: WeChat

    OpenAIRE

    Dai, Si; Zhang, Xin

    2015-01-01

    The objective of this thesis is to find out the functionalities of mobile application. And the purpose of this study is to make a research on WeChat’s functionalities. A native application and mobile web application are the two different types of mobile applications. When designers start to create an application, companies need to discuss which type of app is more suitable for business targets. Each has both pros and cons which influence companies’ choice. WeChat is a popular mobile applicati...

  3. Self versus informant reports on the specific levels of functioning scale: Relationships to depression and cognition in schizophrenia and schizoaffective disorder.

    Science.gov (United States)

    Ermel, Julia; Carter, Cameron S; Gold, James M; MacDonald, Angus W; Daniel Ragland, J; Silverstein, Steven M; Strauss, Milton E; Barch, Deanna M

    2017-09-01

    The goal of the current study was to examine the relationships between insight and both cognitive function and depression in schizophrenia and schizoaffective disorder, and to determine if there were similar relationships across diagnostic categories. We examined discrepancies between self and informant reports of function on the Specific levels of function scale as a metric of insight for interpersonal, social acceptance, work and activities. We examined two samples of individuals with schizophrenia and/or schizoaffective disorder (Ns of 188 and 67 respectively). In Sample 1, cognition was measured using the Dot Probe Expectancy Task. In Sample 2, cognition was measured by averaging several subtests from the MATRICS consensus cognitive battery, as well as additional measures of working memory. In both samples, depression was measured using the Brief Psychiatric Rating Scale. In both samples, we found significant relationships between worse cognition and overestimations of work function, as well as between higher depression levels and underestimation of interpersonal function. These relationships were specific to interpersonal and work function, with significantly stronger correlations with interpersonal and work function compared to the other areas of function. Similar results were found across diagnostic categories. These results have important implications for treatment planning, as they suggest the need to take into account depression and cognitive function when evaluating the patient's self-report of function, and highlight the utility of informant reports in evaluating function and treatment planning. Further, they add to the literature on the similarity across schizophrenia and schizoaffective disorder in a variety of pathological mechanisms.

  4. Self versus informant reports on the specific levels of functioning scale: Relationships to depression and cognition in schizophrenia and schizoaffective disorder

    Directory of Open Access Journals (Sweden)

    Julia Ermel

    2017-09-01

    Full Text Available The goal of the current study was to examine the relationships between insight and both cognitive function and depression in schizophrenia and schizoaffective disorder, and to determine if there were similar relationships across diagnostic categories. We examined discrepancies between self and informant reports of function on the Specific levels of function scale as a metric of insight for interpersonal, social acceptance, work and activities. We examined two samples of individuals with schizophrenia and/or schizoaffective disorder (Ns of 188 and 67 respectively. In Sample 1, cognition was measured using the Dot Probe Expectancy Task. In Sample 2, cognition was measured by averaging several subtests from the MATRICS consensus cognitive battery, as well as additional measures of working memory. In both samples, depression was measured using the Brief Psychiatric Rating Scale. In both samples, we found significant relationships between worse cognition and overestimations of work function, as well as between higher depression levels and underestimation of interpersonal function. These relationships were specific to interpersonal and work function, with significantly stronger correlations with interpersonal and work function compared to the other areas of function. Similar results were found across diagnostic categories. These results have important implications for treatment planning, as they suggest the need to take into account depression and cognitive function when evaluating the patient's self-report of function, and highlight the utility of informant reports in evaluating function and treatment planning. Further, they add to the literature on the similarity across schizophrenia and schizoaffective disorder in a variety of pathological mechanisms.

  5. Functional decline in nursing home residents: A prognostic study.

    Directory of Open Access Journals (Sweden)

    Javier Jerez-Roig

    Full Text Available To verify the probability of maintaining functional capacity in basic activities of daily living and identify the prognostic factors of functional decline in institutionalized older adults.A longitudinal study is presented herein, with 5 waves every 6 months, throughout 2 years (2013-2015, conducted with individuals ≥60 years old in 10 nursing homes in the city of Natal-RN (Brazil. Functional capacity was assessed by the items 'eating', 'personal hygiene', 'dressing', 'bathing', 'transferring', 'toileting' and 'walking', through a 5-item Likert scale. Sociodemographic, institution-related and health-related variables were considered to establish the baseline. Time dependent variables included continence decline, cognitive decline, increase in the number of medication, and incidences of falls, hospitalizations and fractures. The actuarial method, the log-rank test and Cox's regression were applied as statistical methods.The cumulative probability of functional maintenance was 78.2% (CI 95%: 72.8-82.7%, 65.1% (CI 95%: 58.9-70.5%, 53.5% (CI 95%: 47.2-59.5% and 44.0% (CI 95%: 37.7-50.2% at 6, 12, 18 and 24 months, respectively. Predicting factors for functional decline were: severe cognitive impairment (HR = 1.96; p = 0.001, continence decline (HR = 1.85; p = 0.002 and incidence of hospitalizations (HR = 1.62; p = 0.020, adjusted by the incidence of depression, age, education level, presence of chronic diseases and low weight.The cumulative probability of maintaining functional capacity in institutionalized older adults was only 44% at the 2-year follow-up. Prognostic factors for functional decline included severe cognitive impairment, continence decline and incidence of hospitalizations.

  6. Experimental studies on the heavy quark fragmentation functions

    International Nuclear Information System (INIS)

    Bethke, S.

    1985-07-01

    The influence of perturbative QCD gluon radiation and initial state photon radiation on the experimental determination of the heavy quark fragmentation functions is studied in order to extract , the mean of the charm fragmentation function, from the recent measurements of inclusive Dsup(*) production in e + e - annihilation processes. The result is =0.71+-0.014+-0.03, which is scale invariant in the c.m. energy range of 10 GeV to 34 GeV. This result is interpreted in terms of kinematical calculations on heavy quark fragmentation and also compared with results from ν-N-reactions and from investigations of inclusive lepton production in e + e - annihilation. Results of a QCD shower model are in good agreement with the data and offer an alternative description of phenomenological fragmentation functions. (orig.)

  7. Studying Membrane Protein Structure and Function Using Nanodiscs

    DEFF Research Database (Denmark)

    Huda, Pie

    The structure and dynamic of membrane proteins can provide valuable information about general functions, diseases and effects of various drugs. Studying membrane proteins are a challenge as an amphiphilic environment is necessary to stabilise the protein in a functionally and structurally relevant...... form. This is most typically achieved through the use of detergent based reconstitution systems. However, time and again such systems fail to provide a suitable environment causing aggregation and inactivation. Nanodiscs are self-assembled lipoproteins containing two membrane scaffold proteins...... and a lipid bilayer in defined nanometer size, which can act as a stabiliser for membrane proteins. This enables both functional and structural investigation of membrane proteins in a detergent free environment which is closer to the native situation. Understanding the self-assembly of nanodiscs is important...

  8. Functional studies in 79-year-olds. II. Upper extremity function.

    Science.gov (United States)

    Lundgren-Lindquist, B; Sperling, L

    1983-01-01

    As part of the Gerontological and Geriatric Population Study of 79-year-old people in Göteborg, a representative subsample comprising 112 women and 93 men took part in a study of upper extremity function. Thirty-eight per cent of the women and 37% of the men had disorders in the upper extremities. The investigation included tests of co-ordination, static strength in the key-grip and the transversal volar grip, power capacity in opening jars and a bottle, basal movements in the upper extremities in personal hygiene and dressing activities, function in the kitchen e.g. reaching shelves, manual tasks including tests of pronation and supination of the forearm. In the key-grip as well as in the transversal volar grip men showed a generally larger decrease in strength with age than women compared to 70-year-olds in a previous population study. Significant correlations were found between strength in the key-grip and the performance time in the test of co-ordination. Women produced about 66% of the muscular force of the men when opening jars. Significant correlations were found between strength in the transversal volar grip and the maximal torque for opening the jars. Female and male subjects who were not capable of handling the electric plug in the manual ability test had significantly weaker strength in the key-grip. The importance of designing products and adapting the environment so as to correspond to the functional capacity of the elderly, is emphasized.

  9. Executive function influences sedentary behavior: A longitudinal study

    Directory of Open Access Journals (Sweden)

    Paul D. Loprinzi

    2016-10-01

    Full Text Available Background: No study has evaluated the effects of executive function on follow-up sedentary behavior, which was this study’s purpose. Methods: A longitudinal design was employed among 18 young adult college students (Mage = 23.7 years; 88.9% female. Accelerometer-determined sedentary behavior and physical activity, along with executive function, were assessed at baseline. Approximately 8 weeks later, re-assessment of accelerometer-determined sedentary behavior and physical activity occurred. Executive function was assessed using the Parametric Go/No-Go (PGNG computer task. From this, 2 primary executive function outcome parameters were evaluated, including the Simple Rule and Repeating Rule. Results: After adjusting for baseline sedentary behavior, age, gender, body mass index and baseline moderate-to-vigorous physical activity (MVPA, for every 25% increase in the number of correctly identified targets for the Repeating rule at the baseline assessment, participants engaged in 91.8 fewer minutes of sedentary behavior at the follow-up assessment (β = -91.8; 95% CI: -173.5, -10.0; P = 0.03. Results were unchanged when also adjusting for total baseline or follow-up physical activity. Conclusion: Greater executive function is associated with less follow-up sedentary behavior.

  10. Patient-Reported Esthetic and Functional Outcomes of Primary Total Laparoscopic Intestinal Vaginoplasty in Transgender Women With Penoscrotal Hypoplasia.

    Science.gov (United States)

    Bouman, Mark-Bram; van der Sluis, Wouter B; van Woudenberg Hamstra, Leonora E; Buncamper, Marlon E; Kreukels, Baudewijntje P C; Meijerink, Wilhelmus J H J; Mullender, Margriet G

    2016-09-01

    Puberty-suppressing hormonal treatment may result in penoscrotal hypoplasia in transgender women, making standard penile inversion vaginoplasty not feasible. For these patients, intestinal vaginoplasty is a surgical alternative, but knowledge on patient-reported postoperative outcomes and quality of life is lacking. To assess patient-reported functional and esthetic outcomes, quality of life, satisfaction, and sexual well-being after primary total laparoscopic intestinal vaginoplasty in transgender women. A survey study was performed on transgender women who underwent primary total laparoscopic intestinal vaginoplasty with at least 1 year of clinical follow-up. Thirty-one transgender women completed the questionnaires (median age at time of surgery = 19.1 years, range = 18.3-45.0) after a median clinical follow-up of 2.2 years (range = 0.8-7.5). Consenting women were asked to complete a combined questionnaire of the Subjective Happiness Scale, the Satisfaction With Life Scale, Cantril's Ladder of Life Scale, the Female Sexual Function Index, the Female Genital Self-Imaging Scale, the Amsterdam Hyperactive Pelvic Floor Scale-Women, and a questionnaire addressing postoperative satisfaction. Patient-reported functional and esthetic outcomes and postoperative quality of life. Patients graded their life satisfaction a median of 8.0 (range = 4.0-10.0) on Cantril's Ladder of Life Scale. Patients scored a mean total score of 27.7 ± 5.8 on the Satisfaction With Life Scale, which indicated high satisfaction with life, and a mean total score of 5.6 ± 1.4 on the Subjective Happiness Scale. Functionality was graded a median score of 8.0 of 10 (range = 1.0-10.0) and esthetics a score of 8.0 out of 10 (range = 3.0-10.0). The mean Female Sexual Function Index total score of sexually active transgender women was 26.0 ± 6.8. This group of relatively young transgender women reported satisfactory functional and esthetic results of the neovagina and a good quality of life

  11. The Relationship between Self-Reported Executive Functioning and Risk-Taking Behavior in Urban Homeless Youth.

    Science.gov (United States)

    Piche, Joshua; Kaylegian, Jaeson; Smith, Dale; Hunter, Scott J

    2018-01-03

    Introduction: Almost 2 million U.S. youth are estimated to live on the streets, in shelters, or in other types of temporary housing at some point each year. Both their age and living situations make them more likely to engage in high-risk behaviors, particularly during adolescence, a time of increased risk taking. Much of self-control appears related to the development of the prefrontal cortex, which is at a particularly crucial period of elaboration and refinement during adolescence and emerging adulthood. Executive processes like decision-making, inhibition, planning, and reasoning may be vulnerable to adversity experienced as a result of homelessness and related impoverishment during childhood and adolescence. No study to date, to our knowledge, has directly investigated differences in risk-taking by homeless youth as it relates to their developing executive control. Objective: Examine the relationship between the level of self-reported executive function (EF) and engagement in risk taking behaviors among a sample of shelter-living urban homeless youth. We predicted that homeless youth who have lower levels of self-reported EF would more readily engage in risky behaviors that could lead to negative outcomes. Participants: One hundred and forty-nine youths between 18 and 22 years of age were recruited from homeless agencies in Chicago. Of this study sample, 53% were female and 76% African American. Measures: All participants completed, as part of a broader neuropsychological assessment, the Behavior Rating Inventory of Executive Functioning-Adult Version (BRIEF-A), the National Youth Risk Behavior Survey (YRBS), and the Mini-International Neuropsychiatric Interview (MINI). Analyses: Groups were separated based on level of self-reported EF, with two groups identified: High self-reported EF fell >1 SD above the normative average, and low self-reported EF fell >1 SD below the normative average. All analyses utilized Chi-square and Mann-Whitney tests. Results and

  12. Electronic states of aryl radical functionalized graphenes: Density functional theory study

    Science.gov (United States)

    Tachikawa, Hiroto; Kawabata, Hiroshi

    2016-06-01

    Functionalized graphenes are known as a high-performance molecular device. In the present study, the structures and electronic states of the aryl radical functionalized graphene have been investigated by the density functional theory (DFT) method to elucidate the effects of functionalization on the electronic states of graphene (GR). Also, the mechanism of aryl radical reaction with GR was investigated. The benzene, biphenyl, p-terphenyl, and p-quaterphenyl radicals [denoted by (Bz) n (n = 1-4), where n means numbers of benzene rings in aryl radical] were examined as aryl radicals. The DFT calculation of GR-(Bz) n (n = 1-4) showed that the aryl radical binds to the carbon atom of GR, and a C-C single bond was formed. The binding energies of aryl radicals to GR were calculated to be ca. 6.0 kcal mol-1 at the CAM-B3LYP/6-311G(d,p) level. It was found that the activation barrier exists in the aryl radical addition: the barrier heights were calculated to be 10.0 kcal mol-1. The electronic states of GR-(Bz) n were examined on the basis of theoretical results.

  13. Feasibility study report for Operable Unit 4: Volume 1

    International Nuclear Information System (INIS)

    1994-02-01

    This report documents the Feasibility Study (FS) phase of the Fernald Environmental Management Project (FEMP) Operable Unit 4 Remedial Investigation/Feasibility Study (RI/FS) Program. The FEMP, formerly known as the Feed Materials Production Center (FMPC), is a US Department of Energy (DOE) facility that operated from 1952 to 1989. The facility's primarily function was to provide high purity uranium metal products to support United States defense programs. Production operations were suspended in 1989 to focus on environmental restoration and waste management activities at the facility. The RI/FS is being conducted pursuant to the terms of a Consent Agreement between DOE and the US Environmental Protection Agency (EPA) under Sections 120 and 106(a) of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), as amended. The Ohio Environmental Protection Agency (OEPA) is also participating in the RI/FS process at the FEMP through direct involvement in program review meetings and technical review of project documentation. The objective of the RI/FS process is to gather information to support an informed risk management decision regarding which remedy appears to be the most appropriate action for addressing the environmental concerns identified at the FEMP

  14. Feasibility study report for Operable Unit 4: Volume 2

    International Nuclear Information System (INIS)

    1994-02-01

    This report documents the Feasibility Study (FS) phase of the Fernald Environmental Management Project (FEMP) Operable Unit 4 Remedial Investigation/Feasibility Study (RI/FS) Program. The FEMP, formerly known as the Feed Materials Production Center (FMPC), is a US Department of Energy (DOE) facility that operated from 1952 to 1989. The facility's primarily function was to provide high purity uranium metal products to support United States defense programs. Production operations were suspended in 1989 to focus on environmental restoration and waste management activities at the facility. The RI/FS is being conducted pursuant to the terms of a Consent Agreement between DOE and the US Environmental Protection Agency (EPA) under Sections 120 and 106(a) of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), as amended. The Ohio Environmental Protection Agency (OEPA) is also participating in the RI/FS process at the FEMP through direct involvement in program review meetings and technical review of project documentation. The objective of the RI/FS process is to gather information to support an informed risk management decision regarding which remedy appears to be the most appropriate action for addressing the environmental concerns identified at the FEMP. This volume contains appendices A--E

  15. Nanomaterial Case Study: Nanoscale Silver in Disinfectant Spray (Final Report)

    Science.gov (United States)

    EPA announced the release of the final report, Nanomaterial Case Study: Nanoscale Silver in Disinfectant Spray. This report represents a case study of engineered nanoscale silver (nano-Ag), focusing on the specific example of nano-Ag as possibly used in disinfectant spr...

  16. Convergence in Reports of Adolescents' Psychopathology: A Focus on Disorganized Attachment and Reflective Functioning.

    Science.gov (United States)

    Borelli, Jessica L; Palmer, Alexandra; Vanwoerden, Salome; Sharp, Carla

    2017-12-13

    Although convergence in parent-youth reports of adolescent psychopathology is critical for treatment planning, research documents a pervasive lack of agreement in ratings of adolescents' symptoms. Attachment insecurity (particularly disorganized attachment) and impoverished reflective functioning (RF) are 2 theoretically implicated predictors of low convergence that have not been examined in the literature. In a cross-sectional investigation of adolescents receiving inpatient psychiatric treatment, we examined whether disorganized attachment and low (adolescent and parent) RF were associated with patterns of convergence in adolescent internalizing and externalizing symptoms. Compared with organized adolescents, disorganized adolescents had lower parent-youth convergence in reports of their internalizing symptoms and higher convergence in reports of their externalizing symptoms; low adolescent self-focused RF was associated with low convergence in parent-adolescent reports of internalizing symptoms, whereas low adolescent global RF was associated with high convergence in parent-adolescent reports of externalizing symptoms. Among adolescents receiving inpatient psychiatric treatment, disorganized attachment and lower RF were associated with weaker internalizing symptom convergence and greater externalizing symptom convergence, which if replicated, could inform assessment strategies and treatment planning in this setting.

  17. On the Use of Gene Ontology Annotations to Assess Functional Similarity among Orthologs and Paralogs: A Short Report.

    Directory of Open Access Journals (Sweden)

    Paul D Thomas

    Full Text Available A recent paper (Nehrt et al., PLoS Comput. Biol. 7:e1002073, 2011 has proposed a metric for the "functional similarity" between two genes that uses only the Gene Ontology (GO annotations directly derived from published experimental results. Applying this metric, the authors concluded that paralogous genes within the mouse genome or the human genome are more functionally similar on average than orthologous genes between these genomes, an unexpected result with broad implications if true. We suggest, based on both theoretical and empirical considerations, that this proposed metric should not be interpreted as a functional similarity, and therefore cannot be used to support any conclusions about the "ortholog conjecture" (or, more properly, the "ortholog functional conservation hypothesis". First, we reexamine the case studies presented by Nehrt et al. as examples of orthologs with divergent functions, and come to a very different conclusion: they actually exemplify how GO annotations for orthologous genes provide complementary information about conserved biological functions. We then show that there is a global ascertainment bias in the experiment-based GO annotations for human and mouse genes: particular types of experiments tend to be performed in different model organisms. We conclude that the reported statistical differences in annotations between pairs of orthologous genes do not reflect differences in biological function, but rather complementarity in experimental approaches. Our results underscore two general considerations for researchers proposing novel types of analysis based on the GO: 1 that GO annotations are often incomplete, potentially in a biased manner, and subject to an "open world assumption" (absence of an annotation does not imply absence of a function, and 2 that conclusions drawn from a novel, large-scale GO analysis should whenever possible be supported by careful, in-depth examination of examples, to help ensure the

  18. INVESTIGATING TEACHERS’ PROFESSIONAL COMPETENCE: A SYSTEMIC FUNCTIONAL LINGUISTIC ANALYSIS OF TEACHERS’ REPORT TEXTS

    Directory of Open Access Journals (Sweden)

    Sudarsono M. I. Sudarsono

    2017-05-01

    Full Text Available This research aims at observing the teachers’ professional competence by investigating the report texts written by three English teachers in a junior high school in terms of their schematic structures and linguistic features. To achieve this aim, a qualitative case study design involving analysis of English teachers’ report texts and interviews with these English teachers was employed in this research. The results of this research showed that generally the three English teachers have demonstrated sufficient ability in applying appropriate schematic structures and linguistic features relevant to the criteria of a report text. However, the results of this research also indicate that some improvements in understanding and writing a report text, especially in terms of schematic structure, linguistic features, and theme progressions, are needed to enhance the teachers’ subject matter content knowledge about report text.

  19. Data Reports for Retrospective Case Study in Wise County, Texas

    Science.gov (United States)

    Data reports from sampling events collected in wise county, texas as part of EPA's Study of the Potential Impacts of Hydraulic Fracturing for Oil and Gas on Drinking Water Resources, retrospective case study.

  20. Study of functional brain imaging for bilingual language cognition

    International Nuclear Information System (INIS)

    Sun Da

    2008-01-01

    Bilingual and multilingual brain studies of language recognition is an interdisciplinary subject which needs to identify different levels involved in the neural representation of languages, such as neuroanatomical, neurofunctional, biochemical, psychological and linguistic levels. Furthermore, specific factor's such as age, manner of acquisition and environmental factors seem to affect the neural representation. Functional brain imaging, such as PET, SPECT and functional MRI can explore the neurolinguistics representation of bilingualism in the brain in subjects, and elucidate the neuronal mechanisms of bilingual language processing. Functional imaging methods show differences in the pattern of cerebral activation associated with a second language compared with the subject's native language. It shows that verbal memory processing in two unrelated languages is mediated by a common neural system with some distinct cortical areas. The different patterns of activation differ according to the language used. It also could be ascribed either to age of acquisition or to proficiency level. And attained proficiency is more important than age of acquisition as a determinant of the cortical representation of the second language. The study used PET and SPECT shows that sign and spoken language seem to be localized in the same brain areas, and elicit similar regional cerebral blood flow patterns. But for sign language perception, the functional anatomy overlaps that of language processing contain both auditory and visual components. And the sign language is dependent on spatial information too. (authors)

  1. Functional Topography of Human Corpus Callosum: An fMRI Mapping Study

    OpenAIRE

    Fabri, Mara; Polonara, Gabriele

    2013-01-01

    The concept of a topographical map of the corpus callosum (CC) has emerged from human lesion studies and from electrophysiological and anatomical tracing investigations in other mammals. Over the last few years a rising number of researchers have been reporting functional magnetic resonance imaging (fMRI) activation in white matter, particularly the CC. In this study the scope for describing CC topography with fMRI was explored by evoking activation through simple sensory stimulation and moto...

  2. Patient?reported ejaculatory function and satisfaction in men with lower urinary tract symptoms/benign prostatic hyperplasia

    Institute of Scientific and Technical Information of China (English)

    Min Chul Cho; Jung Kwon Kim; Sang Hoon Song; Sung Yong Cho; Sang Wook Lee; Soo Woong Kim; Jae-Seung Paick

    2018-01-01

    This study aimed to investigate perceived ejaculatory function/satisfaction before treatment for lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) and to identify associations between specific categories of ejaculatory dysfunctions (EjDs) and LUTS. A total of 1574 treatment?na?ve men with LUTS/BPH were included in this study. All patients underwent routine evaluation for LUTS/BPH including the International Index of Erectile Function and a 5?item questionnaire developed to assess ejaculatory volume/force/pain/satisfaction/latency time. Patients who had sexual intercourse over the past 4 weeks were classified as sexually active group. A total of 783 patients were categorized as sexually active group. Decreased ejaculatory volume and force were reported by 53.4% and 55.7% of 783 sexually active men, respectively. There was a strong correlation between ejaculatory volume and force. Ejaculatory pain/discomfort, premature ejaculation (PE), and delayed ejaculation (DE) were reported in 41.0%, 16.3%, and 41.4% of the patients, respectively. Over 40.0% of men without decreased ejaculation volume/force were satisfied with ejaculatory function, whereas approximately 6.0% of men with decreased volume/force were satisfied with ejaculatory function. About 30.0% of men with decreased volume/force had orgasmic dysfunction, while approximately 10.0% of men without decreased volume/force did. Decreased ejaculatory volume or force was associated with LUTS severity after adjusting for other influential factors including testosterone level, erectile function, and prostate size on ultrasonography, but PE or DE or ejaculatory pain/discomfort was not. In conclusion, a considerable portion of men with LUTS/BPH appear to have a variety of EjDs. Ejaculatory volume/force and satisfaction/orgasm do not always appear to be concordant. Ejaculatory volume or force is independently associated with LUTS severity, whereas PE or DE or ejaculatory pain/discomfort is not.

  3. Patient-reported ejaculatory function and satisfaction in men with lower urinary tract symptoms/benign prostatic hyperplasia.

    Science.gov (United States)

    Cho, Min Chul; Kim, Jung Kwon; Song, Sang Hoon; Cho, Sung Yong; Lee, Sang Wook; Kim, Soo Woong; Paick, Jae-Seung

    2018-01-01

    This study aimed to investigate perceived ejaculatory function/satisfaction before treatment for lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) and to identify associations between specific categories of ejaculatory dysfunctions (EjDs) and LUTS. A total of 1574 treatment-naïve men with LUTS/BPH were included in this study. All patients underwent routine evaluation for LUTS/BPH including the International Index of Erectile Function and a 5-item questionnaire developed to assess ejaculatory volume/force/pain/satisfaction/latency time. Patients who had sexual intercourse over the past 4 weeks were classified as sexually active group. A total of 783 patients were categorized as sexually active group. Decreased ejaculatory volume and force were reported by 53.4% and 55.7% of 783 sexually active men, respectively. There was a strong correlation between ejaculatory volume and force. Ejaculatory pain/discomfort, premature ejaculation (PE), and delayed ejaculation (DE) were reported in 41.0%, 16.3%, and 41.4% of the patients, respectively. Over 40.0% of men without decreased ejaculation volume/force were satisfied with ejaculatory function, whereas approximately 6.0% of men with decreased volume/force were satisfied with ejaculatory function. About 30.0% of men with decreased volume/force had orgasmic dysfunction, while approximately 10.0% of men without decreased volume/force did. Decreased ejaculatory volume or force was associated with LUTS severity after adjusting for other influential factors including testosterone level, erectile function, and prostate size on ultrasonography, but PE or DE or ejaculatory pain/discomfort was not. In conclusion, a considerable portion of men with LUTS/BPH appear to have a variety of EjDs. Ejaculatory volume/force and satisfaction/orgasm do not always appear to be concordant. Ejaculatory volume or force is independently associated with LUTS severity, whereas PE or DE or ejaculatory pain/discomfort is not.

  4. Resources for Functional Genomics Studies in Drosophila melanogaster

    Science.gov (United States)

    Mohr, Stephanie E.; Hu, Yanhui; Kim, Kevin; Housden, Benjamin E.; Perrimon, Norbert

    2014-01-01

    Drosophila melanogaster has become a system of choice for functional genomic studies. Many resources, including online databases and software tools, are now available to support design or identification of relevant fly stocks and reagents or analysis and mining of existing functional genomic, transcriptomic, proteomic, etc. datasets. These include large community collections of fly stocks and plasmid clones, “meta” information sites like FlyBase and FlyMine, and an increasing number of more specialized reagents, databases, and online tools. Here, we introduce key resources useful to plan large-scale functional genomics studies in Drosophila and to analyze, integrate, and mine the results of those studies in ways that facilitate identification of highest-confidence results and generation of new hypotheses. We also discuss ways in which existing resources can be used and might be improved and suggest a few areas of future development that would further support large- and small-scale studies in Drosophila and facilitate use of Drosophila information by the research community more generally. PMID:24653003

  5. Proton NMR studies of functionalized nanoparticles in aqueous environments

    Science.gov (United States)

    Tataurova, Yulia Nikolaevna

    Nanoscience is an emerging field that can provide potential routes towards addressing critical issues such as clean and sustainable energy, environmental remediation and human health. Specifically, porous nanomaterials, such as zeolites and mesoporous silica, are found in a wide range of applications including catalysis, drug delivery, imaging, environmental protection, and sensing. The characterization of the physical and chemical properties of nanocrystalline materials is essential to the realization of these innovative applications. The great advantage of porous nanocrystals is their increased external surface area that can control their biological, chemical and catalytic activities. Specific functional groups synthesized on the surface of nanoparticles are able to absorb heavy metals from the solution or target disease cells, such as cancer cells. In these studies, three main issues related to functionalized nanomaterials will be addressed through the application of nuclear magnetic resonance (NMR) techniques including: 1) surface composition and structure of functionalized nanocrystalline particles; 2) chemical properties of the guest molecules on the surface of nanomaterials, and 3) adsorption and reactivity of surface bound functional groups. Nuclear magnetic resonance (NMR) is one of the major spectroscopic techniques available for the characterization of molecular structure and conformational dynamics with atomic level detail. This thesis deals with the application of 1H solution state NMR to porous nanomaterial in an aqueous environment. Understanding the aqueous phase behavior of functionalized nanomaterials is a key factor in the design and development of safe nanomaterials because their interactions with living systems are always mediated through the aqueous phase. This is often due to a lack of fundamental knowledge in interfacial chemical and physical phenomena that occur on the surface of nanoparticles. The use of solution NMR spectroscopy results

  6. A study on the quantitative evaluation of skin barrier function

    Science.gov (United States)

    Maruyama, Tomomi; Kabetani, Yasuhiro; Kido, Michiko; Yamada, Kenji; Oikaze, Hirotoshi; Takechi, Yohei; Furuta, Tomotaka; Ishii, Shoichi; Katayama, Haruna; Jeong, Hieyong; Ohno, Yuko

    2015-03-01

    We propose a quantitative evaluation method of skin barrier function using Optical Coherence Microscopy system (OCM system) with coherency of near-infrared light. There are a lot of skin problems such as itching, irritation and so on. It has been recognized skin problems are caused by impairment of skin barrier function, which prevents damage from various external stimuli and loss of water. To evaluate skin barrier function, it is a common strategy that they observe skin surface and ask patients about their skin condition. The methods are subjective judgements and they are influenced by difference of experience of persons. Furthermore, microscopy has been used to observe inner structure of the skin in detail, and in vitro measurements like microscopy requires tissue sampling. On the other hand, it is necessary to assess objectively skin barrier function by quantitative evaluation method. In addition, non-invasive and nondestructive measuring method and examination changes over time are needed. Therefore, in vivo measurements are crucial for evaluating skin barrier function. In this study, we evaluate changes of stratum corneum structure which is important for evaluating skin barrier function by comparing water-penetrated skin with normal skin using a system with coherency of near-infrared light. Proposed method can obtain in vivo 3D images of inner structure of body tissue, which is non-invasive and non-destructive measuring method. We formulate changes of skin ultrastructure after water penetration. Finally, we evaluate the limit of performance of the OCM system in this work in order to discuss how to improve the OCM system.

  7. Developing a Framework for Ankle Function: A Delphi Study

    Science.gov (United States)

    Snyder, Kelli R.; Evans, Todd A.; Neibert, Peter J.

    2014-01-01

    Context: Addressing clinical outcomes is paramount to providing effective health care, yet there is no consensus regarding the appropriate outcomes to address after ankle injuries. Compounding the problem is the repetitive nature of lateral ankle sprains, referred to as functional (FAI) or chronic (CAI) ankle instability. Although they are commonly used terms in practice and research, FAI and CAI are inconsistently defined and assessed. Objective: To establish definitions of a healthy/normal/noninjured ankle, FAI, and CAI, as well as their characteristics and assessment techniques. Design: Delphi study. Setting: Telephone interviews and electronic surveys. Patients or Other Participants: Sixteen experts representing the fields of ankle function and treatment, ankle research, and outcomes assessment and research were selected as panelists. Data Collection and Analysis: A telephone interview produced feedback regarding the definition of, functional characteristics of, and assessment techniques for a healthy/normal/noninjured ankle, an unhealthy/acutely injured ankle, and FAI/CAI. Those data were compiled, reduced, and returned through electronic surveys and were either included by reaching consensus (80% agreement) or excluded. Results: The definitions of a healthy/normal/noninjured ankle and FAI reached consensus. Experts did not agree on a definition of CAI. Eleven functional characteristics of a healthy/normal/noninjured ankle, 32 functional characteristics of an unhealthy/acutely injured ankle, and 13 characteristics of FAI were agreed upon. Conclusions: Although a consensus was reached regarding the definitions and functional characteristics of a healthy/normal/noninjured ankle and FAI, the experts could only agree on 1 characteristic to include in the FAI definition. Several experts did, however, provide additional comments that reinforced the differences in the interpretation of those concepts. Although the experts could not agree on the definition of CAI, its

  8. Self-reported activity level and knee function in amateur football players

    DEFF Research Database (Denmark)

    Frobell, R B; Svensson, E; Göthrick, M

    2008-01-01

    ) amateur football players in 10 football clubs from each division below national level participated in the study. Self-reported Tegner Activity Scale, and the Knee injury and Osteoarthritis Outcome Score (KOOS) are the main outcome measures. Older age, female gender and lower level of competition (football...... is recommended. We suggest that self-reported Tegner Activity Scale scores should be adjusted for age, gender and level of competition. In amateur football players, KOOS scores do not need adjustment for age and gender....

  9. Assessing the completeness of reporting of observational studies in Colombian Journal of Anesthesiology. Cross sectional study

    NARCIS (Netherlands)

    Bravo-Peña, M. (Mary); Barona-Fong, L. (Luis); Campo-López, J. (Julio); Arroyave, Y. (Yeni); J.A. Calvache (Jose Andres)

    2017-01-01

    textabstractIntroduction The STROBE statement (Strengthening the Reporting of Observational Studies in Epidemiology), consisting of 22 points, was published in 2007 with the aim of improving the reporting of observational research. Objective To determine the completeness of reporting of

  10. Patient-Reported Functional Status in Outpatients With Advanced Cancer: Correlation With Physician-Reported Scores and Survival.

    Science.gov (United States)

    Popovic, Gordana; Harhara, Thana; Pope, Ashley; Al-Awamer, Ahmed; Banerjee, Subrata; Bryson, John; Mak, Ernie; Lau, Jenny; Hannon, Breffni; Swami, Nadia; Le, Lisa W; Zimmermann, Camilla

    2018-06-01

    Performance status measures are increasingly completed by patients in outpatient cancer settings, but are not well validated for this use. We assessed performance of a patient-reported functional status measure (PRFS, based on the Eastern Cooperative Oncology Group [ECOG]), compared with the physician-completed ECOG, in terms of agreement in ratings and prediction of survival. Patients and physicians independently completed five-point PRFS (lay version of ECOG) and ECOG measures on first consultation at an oncology palliative care clinic. We assessed agreement between PRFS and ECOG using weighted Kappa statistics, and used linear regression to determine factors associated with the difference between PRFS and ECOG ratings. We used the Kaplan-Meier method to estimate the patients' median survival, categorized by PRFS and ECOG, and assessed predictive accuracy of these measures using the C-statistic. For the 949 patients, there was moderate agreement between PRFS and ECOG (weighted Kappa 0.32; 95% CI: 0.28-0.36). On average, patients' ratings of performance status were worse by 0.31 points (95% CI: 0.25-0.37, P statistic was higher for the average of PRFS and ECOG scores (0.619) than when reported individually (0.596 and 0.604, respectively). Patients tend to rate their performance status worse than physicians, particularly if they are younger or have greater symptom burden. Prognostic ability of performance status could be improved by using the average of patients and physician scores. Copyright © 2018 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

  11. Effects of line dancing on physical function and perceived limitation in older adults with self-reported mobility limitations.

    Science.gov (United States)

    Bennett, Crystal G; Hackney, Madeleine E

    2018-06-01

    Older adults with mobility limitations are at greater risk for aging-related declines in physical function. Line dancing is a popular form of exercise that can be modified, and is thus feasible for older adults with mobility limitations. The purpose of this study was to assess the effects of 8 weeks of line dancing on balance, muscle strength, lower extremity function, endurance, gait speed, and perceived mobility limitations. An experimental design randomly assigned older adults to either an 8-week line dancing or usual care group. The convenience sample consisted of 23 participants with mobility limitations (age range: 65-93 years). The intervention used simple routines from novice line dance classes. At baseline and at 8 weeks, balance, knee muscle strength, lower extremity function, endurance, gait speed, and mobility limitations were measured. ANCOVA tests were conducted on each dependent variable to assess the effects of the intervention over time. Results found significant positive differences for the intervention group in lower extremity function (p dancing significantly improved physical function and reduced self-reported mobility limitations in these individuals. Line dancing could be recommended by clinicians as a potential adjunct therapy that addresses mobility limitations. Implications for Rehabilitation Line dancing may be an alternative exercise for older adults who need modifications due to mobility limitations. Line dancing incorporates cognitive and motor control. Line dancing can be performed alone or in a group setting. Dancing improves balance which can reduce risk of falls.

  12. Radiofrequency thermocoagulation of the thoracic splanchnic nerve in functional abdominal pain syndrome -A case report-.

    Science.gov (United States)

    Choi, Ji-Won; Joo, Eun-Young; Lee, Sang-Hyun; Lee, Chul-Joong; Kim, Tae-Hyeong; Sim, Woo-Seok

    2011-07-01

    The thoracic splanchnic nerve block has been used in managing abdominal pain, especially for pains arising from abdominal cancers. A 27-year-old male patient who had a constant abdominal pain was referred to our clinic for pain management but had no organic disease. The numeric rating scale (NRS) for pain scored 7/10. We applied a diagnostic thoracic splanchnic nerve block under the diagnosis of functional abdominal pain syndrome. Since the block reduced the pain, we applied a radiofrequency thermocoagulation at the T11 and T12 vertebral level. Thereafter, his symptoms improved markedly with pain decreasing to an NRS score of 2-3/10. Hereby, we report a successful management of functional abdominal pain via radiofrequency thermocoagulation of the thoracic splanchnic nerves.

  13. Development of functional genomic tools in trematodes: RNA interference and luciferase reporter gene activity in Fasciola hepatica.

    Directory of Open Access Journals (Sweden)

    Gabriel Rinaldi

    2008-07-01

    Full Text Available The growing availability of sequence information from diverse parasites through genomic and transcriptomic projects offer new opportunities for the identification of key mediators in the parasite-host interaction. Functional genomics approaches and methods for the manipulation of genes are essential tools for deciphering the roles of genes and to identify new intervention targets in parasites. Exciting advances in functional genomics for parasitic helminths are starting to occur, with transgene expression and RNA interference (RNAi reported in several species of nematodes, but the area is still in its infancy in flatworms, with reports in just three species. While advancing in model organisms, there is a need to rapidly extend these technologies to other parasites responsible for several chronic diseases of humans and cattle. In order to extend these approaches to less well studied parasitic worms, we developed a test method for the presence of a viable RNAi pathway by silencing the exogenous reporter gene, firefly luciferase (fLUC. We established the method in the human blood fluke Schistosoma mansoni and then confirmed its utility in the liver fluke Fasciola hepatica. We transformed newly excysted juveniles of F. hepatica by electroporation with mRNA of fLUC and three hours later were able to detect luciferase enzyme activity, concentrated mainly in the digestive ceca. Subsequently, we tested the presence of an active RNAi pathway in F. hepatica by knocking down the exogenous luciferase activity by introduction into the transformed parasites of double-stranded RNA (dsRNA specific for fLUC. In addition, we tested the RNAi pathway targeting an endogenous F. hepatica gene encoding leucine aminopeptidase (FhLAP, and observed a significant reduction in specific mRNA levels. In summary, these studies demonstrated the utility of RNAi targeting reporter fLUC as a reporter gene assay to establish the presence of an intact RNAi pathway in helminth

  14. Study the Relationship of Executive Functions with Behavioral Symptoms in Children with High-Functioning Autism

    Directory of Open Access Journals (Sweden)

    Vali Shiri

    2015-10-01

    Full Text Available Objective: The relation between autism disorder’s symptoms and cognitive capabilities can help with a better phenotype description of this disorder and can facilitate its pathological evaluation and treatment. Destruction of executive functions seems to be one of the cognitive reasons of potential phenotype in autism disorder. Thus, the present paper aims to study the relationship between executive dysfunction and autism disorder’s symptoms. Materials & Methods: In this cross-sectional research, 50 children with high-functioning autism were selected using convenience sampling method from Behara, Tehranpars and Roshd centers. Then, the GARS test and Autism Spectrum Screening Questionnaire was completed by therapists and neuropsychological tests of Strop and continuous performance test and shift attention were taken by the subjects. Pearson correlation coefficient and multi-variant regression were used for data analysis. Results: There is a significant positive relationship between selective attention with communicative and social interaction symptoms, sustained attention with social interaction symptoms and repetitive behaviors, shifting attention with communicative, social interaction and repetitive behavior symptoms (P<0.001 (P<0.01 (P<0.05. In addition, the results of regression analysis also revealed that selective attention and shifting attention can predict communication, and sustained attention can predict social interaction and repetitive behaviors symptoms (P<0.01 (P<0.05. Conclusion: The results obtained by this study indicate the significant role of executive functions in autistic symptoms. Thus, it is recommended to consider new treatment interventions in repairing executive functions for treatment of children with autistic disorder.

  15. The APOSTEL recommendations for reporting quantitative optical coherence tomography studies

    DEFF Research Database (Denmark)

    Cruz-Herranz, Andrés; Balk, Lisanne J; Oberwahrenbrock, Timm

    2016-01-01

    OBJECTIVE: To develop consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results. METHODS: A panel of experienced OCT researchers (including 11 neurologists, 2 ophthalmologists, and 2 neuroscientists) discussed requirements for performing and reporting...... quantitative analyses of retinal morphology and developed a list of initial recommendations based on experience and previous studies. The list of recommendations was subsequently revised during several meetings of the coordinating group. RESULTS: We provide a 9-point checklist encompassing aspects deemed...... relevant when reporting quantitative OCT studies. The areas covered are study protocol, acquisition device, acquisition settings, scanning protocol, funduscopic imaging, postacquisition data selection, postacquisition data analysis, recommended nomenclature, and statistical analysis. CONCLUSIONS...

  16. NMR techniques in the study of cardiovascular structure and functions

    International Nuclear Information System (INIS)

    Osbakken, M.; Haselgrove, J.

    1987-01-01

    The chapter titles of this book are: Introduction to NMR Techniques;Theory of NMR Probe Design;Overview of Magnetic Resonance Imaging to Study the Cardiovascular System;Vascular Anatomy and Physiology Studied with NMR Techniques;Assessment of Myocardial Ischemia and Infarction by Nuclear Magnetic Resonance Imaging;The Use of MRI in Congenital Heart Disease;Cardiomyopathies and Myocarditis Studied with NMR Techniques;Determination of Myocardial Mechanical Function with Magnetic Resonance Imaging Techniques;Determination of Flow Using NMR Techniques;The Use of Contrast Agents in Cardiac MRI;Can Cardiovascular Disease Be Effectively Evaluated with NMR Spectroscopy? NMR Studies of ATP Synthesis Reactions in the Isolated Heart;Studies of Intermediary Metabolism in the Heart by 13C NMR Spectroscopy;23Na and 39K NMR Spectroscopic Studies of the Intact Beating Heart;and Evaluation of Skeletal Muscle Metabolism in Patients with Congestive Heart Failure Using Phosphorus Nuclear Magnetic Resonance

  17. Reveal genes functionally associated with ACADS by a network study.

    Science.gov (United States)

    Chen, Yulong; Su, Zhiguang

    2015-09-15

    Establishing a systematic network is aimed at finding essential human gene-gene/gene-disease pathway by means of network inter-connecting patterns and functional annotation analysis. In the present study, we have analyzed functional gene interactions of short-chain acyl-coenzyme A dehydrogenase gene (ACADS). ACADS plays a vital role in free fatty acid β-oxidation and regulates energy homeostasis. Modules of highly inter-connected genes in disease-specific ACADS network are derived by integrating gene function and protein interaction data. Among the 8 genes in ACADS web retrieved from both STRING and GeneMANIA, ACADS is effectively conjoined with 4 genes including HAHDA, HADHB, ECHS1 and ACAT1. The functional analysis is done via ontological briefing and candidate disease identification. We observed that the highly efficient-interlinked genes connected with ACADS are HAHDA, HADHB, ECHS1 and ACAT1. Interestingly, the ontological aspect of genes in the ACADS network reveals that ACADS, HAHDA and HADHB play equally vital roles in fatty acid metabolism. The gene ACAT1 together with ACADS indulges in ketone metabolism. Our computational gene web analysis also predicts potential candidate disease recognition, thus indicating the involvement of ACADS, HAHDA, HADHB, ECHS1 and ACAT1 not only with lipid metabolism but also with infant death syndrome, skeletal myopathy, acute hepatic encephalopathy, Reye-like syndrome, episodic ketosis, and metabolic acidosis. The current study presents a comprehensible layout of ACADS network, its functional strategies and candidate disease approach associated with ACADS network. Copyright © 2015 Elsevier B.V. All rights reserved.

  18. Buckled graphene: A model study based on density functional theory

    KAUST Repository

    Khan, Yasser

    2010-09-01

    We make use of ab initio calculations within density functional theory to investigate the influence of buckling on the electronic structure of single layer graphene. Our systematic study addresses a wide range of bond length and bond angle variations in order to obtain insights into the energy scale associated with the formation of ripples in a graphene sheet. © 2010 Elsevier B.V. All rights reserved.

  19. Buckled graphene: A model study based on density functional theory

    KAUST Repository

    Khan, Yasser; Mukaddam, Mohsin Ahmed; Schwingenschlö gl, Udo

    2010-01-01

    We make use of ab initio calculations within density functional theory to investigate the influence of buckling on the electronic structure of single layer graphene. Our systematic study addresses a wide range of bond length and bond angle variations in order to obtain insights into the energy scale associated with the formation of ripples in a graphene sheet. © 2010 Elsevier B.V. All rights reserved.

  20. Early-stage cervical carcinoma, radical hysterectomy, and sexual function. A longitudinal study

    DEFF Research Database (Denmark)

    Jensen, Pernille T; Groenvold, Mogens; Klee, Marianne C

    2004-01-01

    with an age-matched control group from the general population. RESULTS: Compared with control women, patients experienced severe orgasmic problems and uncomfortable sexual intercourse due to a reduced vaginal size during the first 6 months after RH, severe dyspareunia during the first 3 months, and sexual......BACKGROUND: Limited knowledge exists concerning the impact of radical hysterectomy (RH) alone on the sexual function of patients with early-stage cervical carcinoma. The authors investigated the longitudinal course of self-reported sexual function after RH. METHODS: The current study was comprised...... dissatisfaction during the 5 weeks after RH. A persistent lack of sexual interest and lubrication were reported throughout the first 2 years after RH. Long-term lack of sexual interest and insufficient vaginal lubrication were confirmed by the patient's self-reported changes 12 months after RH compared...